From d767b07e97e0698b5203eba1288db1dae00c4fc2 Mon Sep 17 00:00:00 2001 From: hkir-dev Date: Mon, 29 Jul 2024 16:15:18 +0100 Subject: [PATCH] dosdp v1 --- clm-base.json | 102 +- clm-base.obo | 69 +- clm-base.owl | 227 +- clm-full.json | 93811 ++++++++++++++-- clm-full.obo | 25953 ++++- clm-full.owl | 85204 +++++++++++++- clm-simple.json | 20 +- clm-simple.obo | 14 +- clm-simple.owl | 28 +- clm.json | 93811 ++++++++++++++-- clm.obo | 25953 ++++- clm.owl | 85204 +++++++++++++- docs/odk-workflows/RepositoryFileStructure.md | 1 + src/markers/NSForestMarkersSource.tsv | 14 +- src/ontology/Makefile | 12 +- src/ontology/clm-edit.owl | 7 +- src/ontology/clm.Makefile | 10 +- src/ontology/imports/genes_terms.txt | 1 + src/ontology/imports/merged_import.owl | 25409 ++++- src/patterns/data/default/MarkersToCells.tsv | 12 +- src/patterns/data/default/NSForestMarkers.tsv | 12 +- src/patterns/definitions.owl | 84 +- .../dosdp-patterns/MarkersToCells.yaml | 32 +- src/patterns/pattern.owl | 25 +- src/scripts/dosdp_template_generator.py | 8 +- src/scripts/robot_template_generator.py | 23 +- 26 files changed, 418675 insertions(+), 17371 deletions(-) create mode 100644 src/ontology/imports/genes_terms.txt diff --git a/clm-base.json b/clm-base.json index f71aeb4..3bee1b4 100644 --- a/clm-base.json +++ b/clm-base.json @@ -16,56 +16,91 @@ "val" : "Cell Markers Ontology" }, { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", - "val" : "2024-07-26" + "val" : "2024-07-29" } ], - "version" : "http://purl.obolibrary.org/obo/clm/releases/2024-07-26/clm-base.json" + "version" : "http://purl.obolibrary.org/obo/clm/releases/2024-07-29/clm-base.json" }, "nodes" : [ { - "id" : "http://identifiers.org/ncbigene/11065", + "id" : "http://identifiers.org/ensembl/ENSG00000038945", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/2168", + "id" : "http://identifiers.org/ensembl/ENSG00000050730", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/286133", + "id" : "http://identifiers.org/ensembl/ENSG00000100292", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/3162", + "id" : "http://identifiers.org/ensembl/ENSG00000131471", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/3248", + "id" : "http://identifiers.org/ensembl/ENSG00000137804", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/4060", + "id" : "http://identifiers.org/ensembl/ENSG00000139329", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/4481", + "id" : "http://identifiers.org/ensembl/ENSG00000163735", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/51203", + "id" : "http://identifiers.org/ensembl/ENSG00000164120", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/57124", + "id" : "http://identifiers.org/ensembl/ENSG00000166803", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/6241", + "id" : "http://identifiers.org/ensembl/ENSG00000168079", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/6374", + "id" : "http://identifiers.org/ensembl/ENSG00000170323", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/79931", + "id" : "http://identifiers.org/ensembl/ENSG00000171848", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/8639", + "id" : "http://identifiers.org/ensembl/ENSG00000174807", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/9768", + "id" : "http://identifiers.org/ensembl/ENSG00000175063", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CLM_0000000", - "lbl" : "root node", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000000", + "type" : "CLASS", + "meta" : { + "comments" : [ "A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000583", + "type" : "CLASS", + "meta" : { + "comments" : [ "A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4028004", + "type" : "CLASS", + "meta" : { + "comments" : [ "A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4028006", + "type" : "CLASS", + "meta" : { + "comments" : [ "A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033041", + "type" : "CLASS", + "meta" : { + "comments" : [ "A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033042", + "type" : "CLASS", + "meta" : { + "comments" : [ "A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4037001", "lbl" : "NS forest marker set of alveolar adventitial fibroblast (Human Lung).", @@ -133,6 +168,11 @@ "id" : "http://purl.obolibrary.org/obo/BFO_0000051", "type" : "PROPERTY", "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0015004", + "lbl" : "has characterizing marker set", + "type" : "PROPERTY", + "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/STATO_0000663", "type" : "PROPERTY", @@ -156,8 +196,36 @@ "lbl" : "title", "type" : "PROPERTY", "propertyType" : "ANNOTATION" + }, { + "id" : "http://www.geneontology.org/formats/oboInOwl#hasDbXref", + "type" : "PROPERTY", + "propertyType" : "ANNOTATION" } ], "edges" : [ { + "sub" : "http://purl.obolibrary.org/obo/CL_0000000", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037006" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000583", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037003" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4028004", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4028006", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037001" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033041", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037004" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033042", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037005" + }, { "sub" : "http://purl.obolibrary.org/obo/CL_4037001", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/SO_0001260" diff --git a/clm-base.obo b/clm-base.obo index 4fc84b0..1ed1003 100644 --- a/clm-base.obo +++ b/clm-base.obo @@ -1,65 +1,96 @@ format-version: 1.2 -data-version: clm/releases/2024-07-26/clm-base.owl +data-version: clm/releases/2024-07-29/clm-base.owl idspace: dce http://purl.org/dc/elements/1.1/ idspace: dcterms http://purl.org/dc/terms/ +idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# ontology: clm/clm-base property_value: dce:type IAO:8000001 property_value: dcterms:description "None" xsd:string property_value: dcterms:license https://creativecommons.org/licenses/unspecified property_value: dcterms:title "Cell Markers Ontology" xsd:string -property_value: owl:versionInfo "2024-07-26" xsd:string +property_value: owl:versionInfo "2024-07-29" xsd:string + +[Term] +id: CL:0000000 +comment: A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26. {xref="https://doi.org/10.5281/zenodo.11165918"} +relationship: RO:0015004 CL:4037006 ! has characterizing marker set NS forest marker set of cell (Human Lung). + +[Term] +id: CL:0000583 +comment: A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8. {xref="https://doi.org/10.5281/zenodo.11165918"} +relationship: RO:0015004 CL:4037003 ! has characterizing marker set NS forest marker set of alveolar macrophage (Human Lung). + +[Term] +id: CL:4028004 +comment: A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7. {xref="https://doi.org/10.5281/zenodo.11165918"} +relationship: RO:0015004 CL:4037002 ! has characterizing marker set NS forest marker set of alveolar type 1 fibroblast cell (Human Lung). + +[Term] +id: CL:4028006 +comment: A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85. {xref="https://doi.org/10.5281/zenodo.11165918"} +relationship: RO:0015004 CL:4037001 ! has characterizing marker set NS forest marker set of alveolar adventitial fibroblast (Human Lung). + +[Term] +id: CL:4033041 +comment: A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67. {xref="https://doi.org/10.5281/zenodo.11165918"} +relationship: RO:0015004 CL:4037004 ! has characterizing marker set NS forest marker set of CCL3-positive alveolar macrophage (Human Lung). + +[Term] +id: CL:4033042 +comment: A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41. {xref="https://doi.org/10.5281/zenodo.11165918"} +relationship: RO:0015004 CL:4037005 ! has characterizing marker set NS forest marker set of metallothionein-positive alveolar macrophage (Human Lung). [Term] id: CL:4037001 name: NS forest marker set of alveolar adventitial fibroblast (Human Lung). is_a: SO:0001260 -relationship: BFO:0000051 http://identifiers.org/ncbigene/286133 -relationship: BFO:0000051 http://identifiers.org/ncbigene/57124 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000168079 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000174807 property_value: STATO:0000663 "0.85" xsd:string [Term] id: CL:4037002 name: NS forest marker set of alveolar type 1 fibroblast cell (Human Lung). is_a: SO:0001260 -relationship: BFO:0000051 http://identifiers.org/ncbigene/4060 -relationship: BFO:0000051 http://identifiers.org/ncbigene/8639 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000131471 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000139329 property_value: STATO:0000663 "0.7" xsd:string [Term] id: CL:4037003 name: NS forest marker set of alveolar macrophage (Human Lung). is_a: SO:0001260 -relationship: BFO:0000051 http://identifiers.org/ncbigene/2168 -relationship: BFO:0000051 http://identifiers.org/ncbigene/4481 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000038945 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000170323 property_value: STATO:0000663 "0.8" xsd:string [Term] id: CL:4037004 name: NS forest marker set of CCL3-positive alveolar macrophage (Human Lung). is_a: SO:0001260 -relationship: BFO:0000051 http://identifiers.org/ncbigene/6374 -relationship: BFO:0000051 http://identifiers.org/ncbigene/79931 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000050730 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000163735 property_value: STATO:0000663 "0.67" xsd:string [Term] id: CL:4037005 name: NS forest marker set of metallothionein-positive alveolar macrophage (Human Lung). is_a: SO:0001260 -relationship: BFO:0000051 http://identifiers.org/ncbigene/3162 -relationship: BFO:0000051 http://identifiers.org/ncbigene/3248 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000100292 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000164120 property_value: STATO:0000663 "0.41" xsd:string [Term] id: CL:4037006 name: NS forest marker set of cell (Human Lung). is_a: SO:0001260 -relationship: BFO:0000051 http://identifiers.org/ncbigene/11065 -relationship: BFO:0000051 http://identifiers.org/ncbigene/51203 -relationship: BFO:0000051 http://identifiers.org/ncbigene/6241 -relationship: BFO:0000051 http://identifiers.org/ncbigene/9768 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000137804 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000166803 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000171848 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000175063 property_value: STATO:0000663 "0.26" xsd:string -[Term] -id: CLM:0000000 -name: root node +[Typedef] +id: RO:0015004 +name: has characterizing marker set diff --git a/clm-base.owl b/clm-base.owl index 8b9dcc1..56202e4 100644 --- a/clm-base.owl +++ b/clm-base.owl @@ -8,14 +8,15 @@ xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" - xmlns:dcterms="http://purl.org/dc/terms/"> + xmlns:dcterms="http://purl.org/dc/terms/" + xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + None Cell Markers Ontology - 2024-07-26 + 2024-07-29 @@ -67,6 +68,12 @@ + + + + + + + + + has characterizing marker set + + + + + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - + - - root node + + + + + + + + + + + + + + A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26. + + + + + A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26. + https://doi.org/10.5281/zenodo.11165918 + + + + + + + + + + + + + + A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8. + + + + + A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8. + https://doi.org/10.5281/zenodo.11165918 + + + + + + + + + + + + + + A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7. + + + + + A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7. + https://doi.org/10.5281/zenodo.11165918 + + + + + + + + + + + + + + A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85. + + + + + A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85. + https://doi.org/10.5281/zenodo.11165918 + + + + + + + + + + + + + + A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67. + + + + + A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67. + https://doi.org/10.5281/zenodo.11165918 + + + + + + + + + + + + + + A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41. + + + + A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41. + https://doi.org/10.5281/zenodo.11165918 + @@ -196,11 +329,11 @@ - + - + @@ -220,11 +353,11 @@ - + - + @@ -244,11 +377,11 @@ - + - + @@ -268,11 +401,11 @@ - + - + @@ -292,11 +425,11 @@ - + - + @@ -316,19 +449,19 @@ - + - + - + - + diff --git a/clm-full.json b/clm-full.json index e2188dd..d058ffb 100644 --- a/clm-full.json +++ b/clm-full.json @@ -13,51 +13,65 @@ "val" : "Cell Markers Ontology" }, { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", - "val" : "2024-07-26" + "val" : "2024-07-29" } ], - "version" : "http://purl.obolibrary.org/obo/clm/releases/2024-07-26/clm-full.json" + "version" : "http://purl.obolibrary.org/obo/clm/releases/2024-07-29/clm-full.json" }, "nodes" : [ { - "id" : "http://identifiers.org/ncbigene/11065", + "id" : "http://identifiers.org/ensembl/ENSG00000038945", + "lbl" : "MSR1", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/2168", + "id" : "http://identifiers.org/ensembl/ENSG00000050730", + "lbl" : "TNIP3", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/286133", + "id" : "http://identifiers.org/ensembl/ENSG00000100292", + "lbl" : "HMOX1", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/3162", + "id" : "http://identifiers.org/ensembl/ENSG00000131471", + "lbl" : "AOC3", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/3248", + "id" : "http://identifiers.org/ensembl/ENSG00000137804", + "lbl" : "NUSAP1", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/4060", + "id" : "http://identifiers.org/ensembl/ENSG00000139329", + "lbl" : "LUM", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/4481", + "id" : "http://identifiers.org/ensembl/ENSG00000163735", + "lbl" : "CXCL5", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/51203", + "id" : "http://identifiers.org/ensembl/ENSG00000164120", + "lbl" : "HPGD", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/57124", + "id" : "http://identifiers.org/ensembl/ENSG00000166803", + "lbl" : "PCLAF", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/6241", + "id" : "http://identifiers.org/ensembl/ENSG00000168079", + "lbl" : "SCARA5", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/6374", + "id" : "http://identifiers.org/ensembl/ENSG00000170323", + "lbl" : "FABP4", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/79931", + "id" : "http://identifiers.org/ensembl/ENSG00000171848", + "lbl" : "RRM2", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/8639", + "id" : "http://identifiers.org/ensembl/ENSG00000174807", + "lbl" : "CD248", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/9768", + "id" : "http://identifiers.org/ensembl/ENSG00000175063", + "lbl" : "UBE2C", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000002", @@ -86,21 +100,36 @@ }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_16646", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_16990", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_16991", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_17087", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_17089", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_17544", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_18059", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_18085", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_18133", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_18154", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_22868", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_24431", "type" : "CLASS" @@ -119,12 +148,21 @@ }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_26764", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_28087", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_28938", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_29067", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_30212", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_3098", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_32952", "type" : "CLASS" @@ -152,15 +190,39 @@ }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_350546", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_35341", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_35352", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_35406", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_35722", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_35757", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_36080", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_36235", + "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_36277", + "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_37163", + "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_37395", + "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_4167", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_50994", "type" : "CLASS" @@ -179,6 +241,9 @@ }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_64628", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_64709", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_6495", "type" : "CLASS" @@ -187,116 +252,328 @@ "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CLM_0000000", - "lbl" : "root node", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000000", "lbl" : "cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.", + "xrefs" : [ "CARO:mah" ] + }, + "comments" : [ "A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26.", "The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one)." ], + "xrefs" : [ { + "val" : "CALOHA:TS-2035" + }, { + "val" : "FMA:68646" + }, { + "val" : "GO:0005623" + }, { + "val" : "KUPO:0000002" + }, { + "val" : "MESH:D002477" + }, { + "val" : "VHOG:0001533" + }, { + "val" : "WBbt:0004017" + }, { + "val" : "XAO:0003012" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000005", "lbl" : "neural crest derived fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is derived from the neural crest.", + "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000006", "lbl" : "neuronal receptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000007", "lbl" : "early embryonic cell (metazoa)", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell found in the embryo before the formation of all the gem layers is complete.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000008", "lbl" : "migratory cranial neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination.", + "xrefs" : [ "ZFA:0007091", "https://orcid.org/0000-0001-5208-3432" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000011", "lbl" : "migratory trunk neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination.", + "xrefs" : [ "ZFA:0007095", "https://orcid.org/0000-0001-5208-3432" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000014", "lbl" : "germ line stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that is the precursor of gametes.", + "xrefs" : [ "doi:10.1016/j.stem.2012.05.016" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000021", "lbl" : "female germ cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Female germ cell is a germ cell that supports female gamete production.", + "xrefs" : [ "GOC:tfm", "PMID:11023867", "PMID:20454446" ] + }, + "xrefs" : [ { + "val" : "MA:0000388" + }, { + "val" : "VHOG:0001530" + }, { + "val" : "ncithesaurus:Egg" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000022", "lbl" : "female germ line stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that is the precursor of female gametes.", + "xrefs" : [ "doi:10.1016/j.stem.2012.05.016" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000023", "lbl" : "oocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A female germ cell that has entered meiosis.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0000964" + }, { + "val" : "CALOHA:TS-0711" + }, { + "val" : "FMA:18644" + }, { + "val" : "MESH:D009865" + }, { + "val" : "WBbt:0006797" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000024", "lbl" : "oogonial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "FMA:83673" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000025", "lbl" : "egg cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0000369" + }, { + "val" : "BTO:0003801" + }, { + "val" : "CALOHA:TS-2191" + }, { + "val" : "FMA:67343" + }, { + "val" : "MESH:D010063" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000027", "lbl" : "smooth muscle cell neural crest derived", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell derived from the neural crest.", + "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000029", "lbl" : "neural crest derived neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neuron that develops from some migratory neural crest cell.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000031", "lbl" : "neuroblast (sensu Vertebrata)", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that will develop into a neuron often after a migration phase.", + "xrefs" : [ "GOC:NV", "http://en.wikipedia.org/wiki/Neuroblast" ] + }, + "xrefs" : [ { + "val" : "BTO:0000930" + }, { + "val" : "FMA:70563" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000034", "lbl" : "stem cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.", + "xrefs" : [ "GOC:tfm", "MESH:D013234" ] + }, + "comments" : [ "This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’." ], + "xrefs" : [ { + "val" : "CALOHA:TS-2086" + }, { + "val" : "FMA:63368" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000035", "lbl" : "single fate stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that self-renews as well as give rise to a single mature cell type.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70569" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000037", "lbl" : "hematopoietic stem cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.", + "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:19022770", "http://en.wikipedia.org/wiki/Hematopoietic_stem_cell" ] + }, + "comments" : [ "Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative." ], + "xrefs" : [ { + "val" : "BTO:0000725" + }, { + "val" : "CALOHA:TS-0448" + }, { + "val" : "FMA:86475" + }, { + "val" : "MESH:D006412" + }, { + "val" : "VHOG:0001485" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000038", "lbl" : "erythroid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell committed to the erythroid lineage.", + "xrefs" : [ "GOC:add", "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "BTO:0004911" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000039", "lbl" : "germ line cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "comments" : [ "Originally this term had some plant germ line cell children." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000040", "lbl" : "monoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus.", + "xrefs" : [ "GOC:add", "PMID:1104740", "http://en.wikipedia.org/wiki/Monoblast", "http://www.copewithcytokines.de" ] + }, + "comments" : [ "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ], + "xrefs" : [ { + "val" : "CALOHA:TS-1195" + }, { + "val" : "FMA:83553" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000048", "lbl" : "multi fate stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that can give rise to multiple lineages of cells.", + "xrefs" : [ "GOC:add" ] + }, + "xrefs" : [ { + "val" : "FMA:84789" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000049", "lbl" : "common myeloid progenitor", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.", + "xrefs" : [ "GOC:add", "ISBN:0878932437", "MESH:D023461" ] + }, + "comments" : [ "This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059)." ], + "xrefs" : [ { + "val" : "BTO:0004730" } ] } }, { @@ -304,69 +581,169 @@ "lbl" : "megakaryocyte-erythroid progenitor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A progenitor cell committed to the megakaryocyte and erythroid lineages.", + "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "MESH:D055015", "PMID:16647566", "http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell" ] + }, + "comments" : [ "MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000051", "lbl" : "common lymphoid progenitor", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A oligopotent progenitor cell committed to the lymphoid lineage.", + "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:10407577", "PMID:16551251" ] + }, + "comments" : [ "CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000052", "lbl" : "totipotent stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell from which all cells of the body can form.", + "xrefs" : [ "GOC:add", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:84790" + }, { + "val" : "MESH:D039901" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000055", "lbl" : "non-terminally differentiated cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A precursor cell with a limited number of potential fates.", + "xrefs" : [ "SANBI:mhl" ] + }, + "comments" : [ "define using PATO mulit-potent or oligopotent?" ], + "xrefs" : [ { + "val" : "BTO:0000125" + }, { + "val" : "FMA:84782" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000056", "lbl" : "myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair.", + "xrefs" : [ "GOC:tfm", "MESH:D032446", "PMID:21849021" ] + }, + "xrefs" : [ { + "val" : "BTO:0000222" + }, { + "val" : "CALOHA:TS-0650" + }, { + "val" : "FMA:70335" + }, { + "val" : "VHOG:0001529" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000057", "lbl" : "fibroblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.", + "xrefs" : [ "ISBN:0517223651", "MESH:D005347", "http://en.wikipedia.org/wiki/Fibroblast" ] + }, + "comments" : [ "These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative." ], + "xrefs" : [ { + "val" : "BTO:0000452" + }, { + "val" : "CALOHA:TS-0362" + }, { + "val" : "FMA:63877" + }, { + "val" : "NCIT:C12482" + }, { + "val" : "VHOG:0001482" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000058", "lbl" : "chondroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell.", + "xrefs" : [ "GOC:tfm", "GO_REF:0000034", "ISBN:0618947256" ] + }, + "xrefs" : [ { + "val" : "BTO:0003607" + }, { + "val" : "FMA:66783" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000064", "lbl" : "ciliated cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that has a filiform extrusion of the cell surface.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "VHOG:0001532" + }, { + "val" : "XAO:0000031" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000066", "lbl" : "epithelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.", + "xrefs" : [ "FB:ma", "GOC:tfm", "MESH:D004847" ] + }, + "xrefs" : [ { + "val" : "BTO:0000414" + }, { + "val" : "CALOHA:TS-2026" + }, { + "val" : "CARO:0000077" + }, { + "val" : "FMA:66768" + }, { + "val" : "WBbt:0003672" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000067", "lbl" : "ciliated epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell that has a cilia.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70605" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000068", "lbl" : "duct epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell that is part of a duct.", + "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000069", "lbl" : "branched duct epithelial cell", @@ -376,69 +753,152 @@ "lbl" : "blood vessel endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An endothelial cell that lines the vasculature.", + "xrefs" : [ "GOC:tfm" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000075", "lbl" : "columnar/cuboidal epithelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.", + "xrefs" : [ "GO:0002065", "https://orcid.org/0000-0001-5208-3432" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000076", "lbl" : "squamous epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "CALOHA:TS-1249" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000077", "lbl" : "mesothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A flattened epithelial cell of mesenchymal origin that lines the serous cavity.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "FMA:66773" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000080", "lbl" : "circulating cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell which moves among different tissues of the body, via blood, lymph, or other medium.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000081", "lbl" : "blood cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell found predominately in the blood.", + "xrefs" : [ "GOC:add", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:62844" + }, { + "val" : "MESH:D001773" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000082", "lbl" : "epithelial cell of lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the lung.", + "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] + }, + "xrefs" : [ { + "val" : "BTO:0004299" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000083", + "lbl" : "epithelial cell of pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the pancreas.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0000028" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000084", "lbl" : "T cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.", + "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ] + }, + "xrefs" : [ { + "val" : "BTO:0000782" + }, { + "val" : "CALOHA:TS-1001" + }, { + "val" : "FMA:62870" + }, { + "val" : "MESH:D013601" + }, { + "val" : "VHOG:0001479" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000092", "lbl" : "osteoclast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.", + "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:10428500", "PMID:15055519", "PMID:17380158" ] + }, + "comments" : [ "Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid." ], + "xrefs" : [ { + "val" : "BTO:0000968" + }, { + "val" : "CALOHA:TS-0721" + }, { + "val" : "FMA:66781" + }, { + "val" : "MESH:D010010" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000094", "lbl" : "granulocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A leukocyte with abundant granules in the cytoplasm.", + "xrefs" : [ "GOC:amm", "GOC:tfm", "MESH:D006098", "http://en.wikipedia.org/wiki/Granulocyte" ] + }, + "xrefs" : [ { + "val" : "BTO:0000539" + }, { + "val" : "BTO:0001026" + }, { + "val" : "CALOHA:TS-0422" + }, { + "val" : "FMA:62854" } ] } }, { @@ -448,15 +908,32 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000098", "lbl" : "sensory epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "ISBN:0721662544" ] + }, + "comments" : [ "The term \"neuroepithelial cell\" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710)." ], + "xrefs" : [ { + "val" : "BTO:0004301" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000099", "lbl" : "interneuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.", + "xrefs" : [ "GOC:tfm", "MESH:D007395" ] + }, + "xrefs" : [ { + "val" : "BTO:0003811" + }, { + "val" : "FMA:67313" + }, { + "val" : "WBbt:0005113" } ] } }, { @@ -464,9 +941,16 @@ "lbl" : "motor neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement.", + "xrefs" : [ "MESH:D009046", "PMID:16875686" ] + }, + "xrefs" : [ { + "val" : "BTO:0000312" + }, { + "val" : "FMA:83617" + }, { + "val" : "WBbt:0005409" } ] } }, { @@ -474,23 +958,44 @@ "lbl" : "sensory neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Any neuron having a sensory function; an afferent neuron conveying sensory impulses.", + "xrefs" : [ "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0001037" + }, { + "val" : "FMA:84649" + }, { + "val" : "MESH:D011984" + }, { + "val" : "WBbt:0005759" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000107", "lbl" : "autonomic neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron whose cell body is within an autonomic ganglion.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:80121" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000113", "lbl" : "mononuclear phagocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A vertebrate phagocyte with a single nucleus.", + "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ] + }, + "xrefs" : [ { + "val" : "BTO:0001433" } ] } }, { @@ -498,9 +1003,17 @@ "lbl" : "endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.", + "xrefs" : [ "GOC:tfm", "MESH:D042783", "PMID:21275341", "http://en.wikipedia.org/wiki/Endothelial_cell", "https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855" ] + }, + "comments" : [ "From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]." ], + "xrefs" : [ { + "val" : "BTO:0001176" + }, { + "val" : "CALOHA:TS-0278" + }, { + "val" : "FMA:66772" } ] } }, { @@ -512,41 +1025,105 @@ "lbl" : "glial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.", + "xrefs" : [ "MESH:D009457" ] + }, + "comments" : [ "Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571" ], + "xrefs" : [ { + "val" : "BTO:0002606" + }, { + "val" : "CALOHA:TS-0415" + }, { + "val" : "FMA:54536" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000133", "lbl" : "neurectodermal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ectoderm destined to be nervous tissue.", + "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000134", "lbl" : "mesenchymal stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.", + "xrefs" : [ "FB:ma", "GOC:dsd", "PMCID:PMC2613570", "PMID:10102814", "PMID:16923606", "PMID:17986482", "PMID:19960544", "http://en.wikipedia.org/wiki/Mesenchymal_stem_cell", "http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells" ] + }, + "comments" : [ "Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2." ], + "xrefs" : [ { + "val" : "BTO:0002625" + }, { + "val" : "BTO:0003298" + }, { + "val" : "FMA:70546" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000136", "lbl" : "adipocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.", + "xrefs" : [ "MESH:D017667" ] + }, + "xrefs" : [ { + "val" : "BTO:0000443" + }, { + "val" : "CALOHA:TS-0012" + }, { + "val" : "FMA:63880" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000138", "lbl" : "chondrocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell.", + "xrefs" : [ "GO_REF:0000034", "MESH:D019902" ] + }, + "xrefs" : [ { + "val" : "BTO:0000249" + }, { + "val" : "CALOHA:TS-0138" + }, { + "val" : "FMA:66782" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000145", "lbl" : "professional antigen presenting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000147", "lbl" : "pigment cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pigment cell is a cell that contains pigment granules.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "VHOG:0001678" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000149", "lbl" : "visual pigment cell", @@ -554,35 +1131,89 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000150", "lbl" : "glandular epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2085" + }, { + "val" : "FMA:86494" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000151", "lbl" : "secretory cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that specializes in controlled release of one or more substances.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0003659" + }, { + "val" : "FMA:86916" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000152", "lbl" : "exocrine cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "FMA:16014" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000153", "lbl" : "glycosaminoglycan secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that secretes glycosaminoglycans.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000154", "lbl" : "protein secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some protein secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000157", "lbl" : "surfactant secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that specializes in secretion of surfactant in the alveoli of the lung.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000158", "lbl" : "club cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium.", + "xrefs" : [ "DOI:10.1183/09031936.00146609", "DOI:10.1378/chest.12-2762", "GOC:tfm", "PMID:28128362", "PMID:29874100", "PMID:7905712" ] + }, + "xrefs" : [ { + "val" : "BTO:0004811" + }, { + "val" : "FMA:14119" } ] } }, { @@ -594,57 +1225,221 @@ "lbl" : "endocrine cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.", + "xrefs" : [ "MESH:D055098" ] + }, + "xrefs" : [ { + "val" : "FMA:83809" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000164", "lbl" : "enteroendocrine cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas.", + "xrefs" : [ "GOC:tfm", "SANBI:mhl" ] + }, + "xrefs" : [ { + "val" : "BTO:0003865" + }, { + "val" : "FMA:62930" + }, { + "val" : "MESH:D019858" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000165", "lbl" : "neuroendocrine cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A neuron that is capable of some hormone secretion in response to neuronal signals.", + "xrefs" : [ "MESH:D055099" ] + }, + "comments" : [ "The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron." ], + "xrefs" : [ { + "val" : "BTO:0002691" + }, { + "val" : "FMA:83810" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000167", "lbl" : "peptide hormone secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some peptide hormone secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000168", + "lbl" : "insulin secreting cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some insulin secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "BTO:0000783" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000169", + "lbl" : "type B pancreatic cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that secretes insulin and is located towards the center of the islets of Langerhans.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Pancreatic_b_cell" ] + }, + "comments" : [ "Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression." ], + "xrefs" : [ { + "val" : "BTO:0000783" + }, { + "val" : "EV:0200009" + }, { + "val" : "FMA:70586" + }, { + "val" : "MA:0002419" + }, { + "val" : "ncithesaurus:Beta_Cell" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000170", "lbl" : "glucagon secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that secretes glucagon.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:84045" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000171", + "lbl" : "pancreatic A cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0000990" + }, { + "val" : "FMA:70585" + }, { + "val" : "MESH:D050416" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000172", "lbl" : "somatostatin secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some somatostatin secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000173", + "lbl" : "pancreatic D cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin.", + "xrefs" : [ "FMA:0517223651", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0000803" + }, { + "val" : "FMA:70587" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000174", "lbl" : "steroid hormone secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some steroid hormone secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000182", + "lbl" : "hepatocyte", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated.", + "xrefs" : [ "GOC:tfm", "ISBN:0412046911", "MESH:D022781", "PMID:19717280", "http://en.wikipedia.org/wiki/Hepatocyte" ] + }, + "comments" : [ "Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive." ], + "xrefs" : [ { + "val" : "BTO:0000575" + }, { + "val" : "CALOHA:TS-0454" + }, { + "val" : "FMA:14515" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000183", "lbl" : "contractile cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose primary function is to shorten.", + "xrefs" : [ "FB:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000187", "lbl" : "muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.", + "xrefs" : [ "MESH:D032342" ] + }, + "xrefs" : [ { + "val" : "BTO:0000888" + }, { + "val" : "BTO:0000902" + }, { + "val" : "CALOHA:TS-2032" + }, { + "val" : "FMA:67328" + }, { + "val" : "WBbt:0003675" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000188", "lbl" : "cell of skeletal muscle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A somatic cell located in skeletal muscle.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004392" + }, { + "val" : "CALOHA:TS-2158" + }, { + "val" : "FMA:9727" } ] } }, { @@ -652,9 +1447,16 @@ "lbl" : "smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast).", + "xrefs" : [ "MESH:D032389", "PMID:9315361", "http://en.wikipedia.org/wiki/Smooth_muscle_cell" ] + }, + "xrefs" : [ { + "val" : "BTO:0004576" + }, { + "val" : "CALOHA:TS-2159" + }, { + "val" : "FMA:14072" } ] } }, { @@ -664,24 +1466,58 @@ "meta" : { "definition" : { "val" : "A cell that is capable of detection of a stimulus involved in sensory perception." - } + }, + "xrefs" : [ { + "val" : "MESH:D011984" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000206", "lbl" : "chemoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood.", + "xrefs" : [ "MESH:D002628" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000210", "lbl" : "photoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell specialized to detect and transduce light.", + "xrefs" : [ "MESH:D010786" ] + }, + "xrefs" : [ { + "val" : "BTO:0001060" + }, { + "val" : "CALOHA:TS-0868" + }, { + "val" : "FMA:86740" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000211", "lbl" : "electrically active cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose function is determined by the generation or the reception of an electric signal.", + "xrefs" : [ "FB:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000213", "lbl" : "lining cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism.", + "xrefs" : [ "JB:jb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000214", "lbl" : "synovial cell", @@ -689,86 +1525,209 @@ "meta" : { "definition" : { "val" : "A cell located in the synovial joint." - } + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0995" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000215", "lbl" : "barrier cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose primary function is to prevent the transport of stuff across compartments.", + "xrefs" : [ "JB:jb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000219", "lbl" : "motile cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that moves by its own activities.", + "xrefs" : [ "FB:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000221", "lbl" : "ectodermal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the outer of the three germ layers of the embryo.", + "xrefs" : [ "MESH:D004475" ] + }, + "xrefs" : [ { + "val" : "FMA:72549" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000222", "lbl" : "mesodermal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the middle germ layer of the embryo.", + "xrefs" : [ "MESH:D008648" ] + }, + "xrefs" : [ { + "val" : "FMA:72554" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000223", "lbl" : "endodermal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the inner of the three germ layers of the embryo.", + "xrefs" : [ "MESH:D004707" ] + }, + "xrefs" : [ { + "val" : "FMA:72555" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000226", "lbl" : "single nucleate cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell with a single nucleus.", + "xrefs" : [ "FB:ma", "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000228", "lbl" : "multinucleate cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell with more than one nucleus.", + "xrefs" : [ "FB:ma" ] + }, + "xrefs" : [ { + "val" : "AEO:0000203" + }, { + "val" : "WBbt:0008074" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000232", "lbl" : "erythrocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.", + "xrefs" : [ "GOC:tfm", "MESH:D004912" ] + }, + "xrefs" : [ { + "val" : "BTO:0000424" + }, { + "val" : "CALOHA:TS-0290" + }, { + "val" : "FMA:81100" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000234", "lbl" : "phagocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell capable of ingesting particulate matter via phagocytosis.", + "xrefs" : [ "GOC:add", "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "BTO:0001044" + }, { + "val" : "FMA:83806" + }, { + "val" : "MESH:D010586" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000235", "lbl" : "macrophage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.", + "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "PMID:16213494", "PMID:1919437" ] + }, + "comments" : [ "Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid." ], + "xrefs" : [ { + "val" : "BTO:0000801" + }, { + "val" : "CALOHA:TS-0587" + }, { + "val" : "FMA:63261" + }, { + "val" : "FMA:83585" + }, { + "val" : "MESH:D008264" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000255", "lbl" : "eukaryotic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that only exists in Eukaryota.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "MESH:D005057" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000257", "lbl" : "Eumycetozoan cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that only exists in Eumycetozoa.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000287", "lbl" : "eye photoreceptor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any photoreceptor cell that is part of some eye.", + "xrefs" : [ "FBC:Autogenerated" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000293", "lbl" : "structural cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism.", + "xrefs" : [ "TAIR:sr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000300", "lbl" : "gamete", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mature sexual reproductive cell having a single set of unpaired chromosomes.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0395" + }, { + "val" : "FMA:18649" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000306", "lbl" : "crystallin accumulating cell", @@ -776,19 +1735,72 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000307", "lbl" : "tracheal epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell found in the trachea.", + "xrefs" : [ "GOC:tfm" ] + }, + "comments" : [ "This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'" ], + "xrefs" : [ { + "val" : "FMA:74793" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000313", "lbl" : "serous secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0003687" + }, { + "val" : "FMA:62511" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000319", + "lbl" : "mucus secreting cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some mucus secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "BTO:0003689" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000322", "lbl" : "pulmonary alveolar epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates.", + "xrefs" : [ "GOC:tfm", "PMID:20054144", "PMID:29463737" ] + }, + "xrefs" : [ { + "val" : "BTO:0000395" + }, { + "val" : "CALOHA:TS-2168" + }, { + "val" : "FMA:62499" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000325", "lbl" : "stuff accumulating cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that is specialised to accumulate a particular substance(s).", + "xrefs" : [ "FB:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000327", "lbl" : "extracellular matrix secreting cell", @@ -796,61 +1808,174 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000329", "lbl" : "oxygen accumulating cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that is capable of some oxygen transport.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000333", "lbl" : "migratory neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body.", + "xrefs" : [ "doi:10.1016/j.stem.2015.02.017" ] + }, + "xrefs" : [ { + "val" : "FMA:86667" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000335", "lbl" : "mesenchyme condensation cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors.", + "xrefs" : [ "GOC:tfm", "PMID:5025404" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000347", "lbl" : "scleral cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the sclera of the eye.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000348", "lbl" : "choroidal cell of the eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structural cell that is part of optic choroid.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000349", "lbl" : "extraembryonic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that is part of some extraembryonic structure.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000351", "lbl" : "trophoblast cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface.", + "xrefs" : [ "GOC:tfm", "MESH:D014327" ] + }, + "xrefs" : [ { + "val" : "FMA:83028" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000352", "lbl" : "epiblast cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation.", + "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000353", "lbl" : "blastoderm cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote).", + "xrefs" : [ "MESH:D001756" ] + }, + "xrefs" : [ { + "val" : "BTO:0001473" + }, { + "val" : "FMA:72551" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000355", "lbl" : "multi-potent skeletal muscle stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell.", + "xrefs" : [ "PMID:18282570" ] + }, + "comments" : [ "Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo." ], + "xrefs" : [ { + "val" : "FMA:86767" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000358", + "lbl" : "sphincter associated smooth muscle cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.", + "xrefs" : [ "GOC:cjm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000359", "lbl" : "vascular associated smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A smooth muscle cell associated with the vasculature.", + "xrefs" : [ "GOC:dsd", "GOC:tfm" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000362", "lbl" : "epidermal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the integument (the outer layer of an organism).", + "xrefs" : [ "Flybase:dsj", "MA:ma" ] + }, + "xrefs" : [ { + "val" : "BTO:0001470" + }, { + "val" : "CALOHA:TS-0283" + }, { + "val" : "FMA:62411" + }, { + "val" : "MESH:D000078404" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000365", "lbl" : "animal zygote", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Diploid cell produced by the fusion of sperm cell nucleus and egg cell.", + "xrefs" : [ "ISBN:0471245208" ] + }, + "xrefs" : [ { + "val" : "BTO:0000854" + }, { + "val" : "EHDAA2:0004546" + }, { + "val" : "FMA:72395" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000377", "lbl" : "tracheoblast", @@ -858,28 +1983,67 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000393", "lbl" : "electrically responsive cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose function is determined by its response to an electric signal.", + "xrefs" : [ "FB:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000397", "lbl" : "ganglion interneuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any interneuron that has its soma located in some ganglion.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000402", "lbl" : "CNS interneuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An interneuron that has its cell body in a central nervous system.", + "xrefs" : [ "doi:10.1016/B978-0-12-817424-1.00001-X" ] + }, + "comments" : [ "Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000404", "lbl" : "electrically signaling cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that initiates an electrical signal and passes that signal to another cell.", + "xrefs" : [ "FB:ma" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000412", + "lbl" : "polyploid cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that contains more than two haploid sets of chromosomes.", + "xrefs" : [ "FB:ma", "PMID:32646579", "https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000413", "lbl" : "haploid cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose nucleus contains a single haploid genome.", + "xrefs" : [ "FB:ma", "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000417", + "lbl" : "endopolyploid cell", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000447", @@ -890,9 +2054,18 @@ "lbl" : "dendritic cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "xrefs" : [ { + "val" : "BTO:0002042" + }, { + "val" : "CALOHA:TS-0194" + }, { + "val" : "FMA:83036" + }, { + "val" : "MESH:D003713" } ] } }, { @@ -902,57 +2075,186 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000458", "lbl" : "serotonin secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell type that secretes 5-Hydroxytryptamine (serotonin).", + "xrefs" : [ "GOC:tfm", "PMID:19630576" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000459", "lbl" : "noradrenergic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme.", + "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000473", "lbl" : "defensive cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose primary function is to protect the organism.", + "xrefs" : [ "JB:jb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000488", "lbl" : "visible light photoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A photoreceptor cell that detects visible light.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000499", "lbl" : "stromal cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.", + "xrefs" : [ "GOC:tfm", "MESH:D017154" ] + }, + "xrefs" : [ { + "val" : "BTO:0002064" + }, { + "val" : "FMA:83624" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000502", + "lbl" : "type D enteroendocrine cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin.", + "xrefs" : [ "MESH:D019864" ] + }, + "xrefs" : [ { + "val" : "FMA:62935" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000506", + "lbl" : "enkephalin secreting cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endorphine cell that secretes enkephalin.", + "xrefs" : [ "GO:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000507", + "lbl" : "endorphin secreting cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A peptide hormone secreting cell that secretes endorphin.", + "xrefs" : [ "GO:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000508", + "lbl" : "type G enteroendocrine cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "MESH:D019863" ] + }, + "xrefs" : [ { + "val" : "BTO:0004108" + }, { + "val" : "FMA:67609" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000509", + "lbl" : "gastrin secreting cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A peptide hormone secreting cell that secretes gastrin.", + "xrefs" : [ "GO:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000513", "lbl" : "cardiac muscle myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A precursor cell destined to differentiate into cardiac muscle cell.", + "xrefs" : [ "GOC:tfm", "MESH:D032386" ] + }, + "xrefs" : [ { + "val" : "FMA:84797" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000514", "lbl" : "smooth muscle myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A precursor cell destined to differentiate into smooth muscle myocytes.", + "xrefs" : [ "GOC:tfm", "MESH:D032390" ] + }, + "xrefs" : [ { + "val" : "FMA:84798" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000515", "lbl" : "skeletal muscle myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myoblast that differentiates into skeletal muscle fibers.", + "xrefs" : [ "SANBI:mhl" ] + }, + "xrefs" : [ { + "val" : "FMA:84799" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000518", "lbl" : "phagocyte (sensu Vertebrata)", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A phagocyte in vertebrates that is able to phagocytosis.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000521", "lbl" : "fungal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that only exists in Fungi.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000525", "lbl" : "syncytiotrophoblast cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.", + "xrefs" : [ "GOC:tfm", "ISBN:0323052908" ] + }, + "xrefs" : [ { + "val" : "FMA:83043" } ] } }, { @@ -960,23 +2262,44 @@ "lbl" : "afferent neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A neuron which conveys sensory information centrally from the periphery.", + "xrefs" : [ "GOC:tfm", "MESH:D009475" ] + }, + "xrefs" : [ { + "val" : "FMA:87653" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000527", "lbl" : "efferent neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron which sends impulses peripherally to activate muscles or secretory cells.", + "xrefs" : [ "MESH:D009476" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000540", "lbl" : "neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.", + "xrefs" : [ "MESH:D009474", "http://en.wikipedia.org/wiki/Neuron" ] + }, + "comments" : [ "These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma." ], + "xrefs" : [ { + "val" : "BTO:0000938" + }, { + "val" : "CALOHA:TS-0683" + }, { + "val" : "FMA:54527" + }, { + "val" : "VHOG:0001483" + }, { + "val" : "WBbt:0003679" } ] } }, { @@ -984,35 +2307,93 @@ "lbl" : "lymphocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.", + "xrefs" : [ "GOC:add", "ISBN:0683073696", "ISBN:0781735149" ] + }, + "comments" : [ "Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)" ], + "xrefs" : [ { + "val" : "BTO:0000775" + }, { + "val" : "CALOHA:TS-0583" + }, { + "val" : "FMA:62863" + }, { + "val" : "MESH:D008214" + }, { + "val" : "VHOG:0001535" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000547", "lbl" : "proerythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.", + "xrefs" : [ "ISBN:0721601464", "PMID:1638021" ] + }, + "xrefs" : [ { + "val" : "FMA:83518" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000549", "lbl" : "basophilic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers.", + "xrefs" : [ "GOC:tfm", "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "FMA:83505" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000550", "lbl" : "polychromatophilic erythroblast", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/CL_0000552", - "lbl" : "orthochromatic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers.", + "xrefs" : [ "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "FMA:83506" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000552", + "lbl" : "orthochromatic erythroblast", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated.", + "xrefs" : [ "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "FMA:84646" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000553", "lbl" : "megakaryocyte progenitor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).", + "xrefs" : [ "GOC:dsd", "GOC:tfm", "ISBN:0721601464" ] + }, + "comments" : [ "Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative." ], + "xrefs" : [ { + "val" : "BTO:0001164" + }, { + "val" : "CALOHA:TS-0610" + }, { + "val" : "FMA:84235" + }, { + "val" : "MESH:D055016" } ] } }, { @@ -1020,9 +2401,17 @@ "lbl" : "megakaryocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release.", + "xrefs" : [ "ISBN:0721601464", "MESH:D008533", "PMID:31043076", "http://en.wikipedia.org/wiki/Megakaryocyte" ] + }, + "comments" : [ "Megakaryocytes are reportedly CD181-positive and CD182-positive." ], + "xrefs" : [ { + "val" : "BTO:0000843" + }, { + "val" : "CALOHA:TS-0611" + }, { + "val" : "FMA:83555" } ] } }, { @@ -1030,45 +2419,91 @@ "lbl" : "granulocyte monocyte progenitor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.", + "xrefs" : [ "GOC:amm", "GOC:dsd", "GOC:tfm", "GO_REF:0000031", "ISBN:0721601464", "MESH:D055014", "PMCID:PMC2213186", "PMCID:PMC548021", "PMID:16551251", "PMID:16647566", "http://en.wikipedia.org/wiki/CFU-GM", "http://www.copewithcytokines.de" ] + }, + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000558", "lbl" : "reticulocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds.", + "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:15946868", "PMID:2037622" ] + }, + "xrefs" : [ { + "val" : "BTO:0001173" + }, { + "val" : "CALOHA:TS-0864" + }, { + "val" : "MESH:D012156" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000559", "lbl" : "promonocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules.", + "xrefs" : [ "GOC:tfm", "ISBN:0721601464" ] + }, + "comments" : [ "Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ], + "xrefs" : [ { + "val" : "BTO:0004657" + }, { + "val" : "FMA:83551" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000562", "lbl" : "nucleate erythrocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An erythrocyte having a nucleus.", + "xrefs" : [ "GOC:add", "GOc:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000566", "lbl" : "angioblastic mesenchymal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal stem cell capable of developing into blood vessel endothelium.", + "xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ] + }, + "comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000569", "lbl" : "cardiac mesenchymal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field.", + "xrefs" : [ "PMID:18816864" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000573", "lbl" : "retinal cone cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.", + "xrefs" : [ "MESH:D017949" ] + }, + "xrefs" : [ { + "val" : "BTO:0001036" + }, { + "val" : "CALOHA:TS-0866" + }, { + "val" : "FMA:67748" } ] } }, { @@ -1076,9 +2511,16 @@ "lbl" : "corneal epithelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelial cell of the cornea.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004298" + }, { + "val" : "CALOHA:TS-0173" + }, { + "val" : "FMA:70551" } ] } }, { @@ -1086,9 +2528,17 @@ "lbl" : "monocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.", + "xrefs" : [ "GO_REF:0000031", "MESH:D009000" ] + }, + "comments" : [ "Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid." ], + "xrefs" : [ { + "val" : "BTO:0000876" + }, { + "val" : "CALOHA:TS-0638" + }, { + "val" : "FMA:62864" } ] } }, { @@ -1096,83 +2546,244 @@ "lbl" : "alveolar macrophage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative.", + "xrefs" : [ "GOC:ana", "GOC:dsd", "GOC:tfm", "GO_REF:0000031", "MESH:D016676" ] + }, + "comments" : [ "A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8.", "Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-." ], + "xrefs" : [ { + "val" : "BTO:0000802" + }, { + "val" : "CALOHA:TS-0030" + }, { + "val" : "FMA:83023" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000586", "lbl" : "germ cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The reproductive cell in multicellular organisms.", + "xrefs" : [ "MESH:D005854" ] + }, + "xrefs" : [ { + "val" : "BTO:0000535" + }, { + "val" : "NCIT:C12597" + }, { + "val" : "VHOG:0001534" + }, { + "val" : "WBbt:0006796" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000593", "lbl" : "androgen secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A steroid hormone secreting cell that secretes androgen.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000604", "lbl" : "retinal rod cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision.", + "xrefs" : [ "MESH:D017948" ] + }, + "xrefs" : [ { + "val" : "BTO:0001024" + }, { + "val" : "CALOHA:TS-0870" + }, { + "val" : "FMA:67747" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000622", + "lbl" : "acinar cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus).", + "xrefs" : [ "GOC:tfm", "http://www.copewithcytokines.de" ] + }, + "xrefs" : [ { + "val" : "FMA:83625" + }, { + "val" : "MESH:D061354" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000630", "lbl" : "supporting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose primary function is to support other cell types.", + "xrefs" : [ "FB:ma", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0002315" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000666", + "lbl" : "fenestrated endothelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues.", + "xrefs" : [ "DOI:10.1007/978-3-211-99390-3_133" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000667", "lbl" : "collagen secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An extracellular matrix secreting cell that secretes collagen.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000669", "lbl" : "pericyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells.", + "xrefs" : [ "GOC:dsd", "GOC:tfm", "ISBN:0721662544", "MESH:D020286", "PMID:16807374", "PMID:17986482", "PMID:20024907" ] + }, + "comments" : [ "Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A." ], + "xrefs" : [ { + "val" : "BTO:0002441" + }, { + "val" : "FMA:63174" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000670", "lbl" : "primordial germ cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells.", + "xrefs" : [ "GOC:tfm", "PMID:1381289" ] + }, + "xrefs" : [ { + "val" : "FMA:70567" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000675", "lbl" : "female gamete", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mature sexual reproductive cell of the female germline.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000680", "lbl" : "muscle precursor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A non-terminally differentiated cell that is capable of developing into a muscle cell.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000696", "lbl" : "PP cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that stores and secretes pancreatic polypeptide hormone.", + "xrefs" : [ "GOC:tfm", "JB:jb", "PMID:15153415" ] + }, + "xrefs" : [ { + "val" : "FMA:62938" + }, { + "val" : "FMA:83409" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000710", "lbl" : "neurecto-epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial cells derived from neural plate and neural crest.", + "xrefs" : [ "GOC:tfm" ] + }, + "comments" : [ "The term \"neuroepithelial cell\" is used to describe both this cell type and sensory epithelial cell (CL:0000098)." ], + "xrefs" : [ { + "val" : "BTO:0004301" + }, { + "val" : "FMA:70557" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000723", "lbl" : "somatic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that can give rise to cell types of the body other than those of the germ-line.", + "xrefs" : [ "GO:0048103" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2086" + }, { + "val" : "MESH:D053687" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000737", "lbl" : "striated muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle cell which has as its direct parts myofilaments organized into sarcomeres.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0002916" + }, { + "val" : "CALOHA:TS-2157" + }, { + "val" : "FMA:86936" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000738", "lbl" : "leukocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.", + "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:978-0-323-05290-0" ] + }, + "xrefs" : [ { + "val" : "BTO:0000751" + }, { + "val" : "CALOHA:TS-0549" + }, { + "val" : "FMA:62852" + }, { + "val" : "MESH:D007962" + }, { + "val" : "NCIT:C12529" } ] } }, { @@ -1180,9 +2791,16 @@ "lbl" : "retinal ganglion cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.", + "xrefs" : [ "GOC:dph" ] + }, + "xrefs" : [ { + "val" : "BTO:0001800" + }, { + "val" : "FMA:67765" + }, { + "val" : "MESH:D012165" } ] } }, { @@ -1190,327 +2808,804 @@ "lbl" : "cardiac muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.", + "xrefs" : [ "GOC:mtg_cardiacconduct_nov11", "GOC:tfm", "ISBN:0323052908", "PMID:22426062", "PMID:4711263" ] + }, + "comments" : [ "This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction." ], + "xrefs" : [ { + "val" : "BTO:0001539" + }, { + "val" : "CALOHA:TS-0115" + }, { + "val" : "FMA:14067" + }, { + "val" : "MESH:D032383" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000763", "lbl" : "myeloid cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.", + "xrefs" : [ "GOC:add" ] + }, + "xrefs" : [ { + "val" : "BTO:0001441" + }, { + "val" : "CALOHA:TS-0647" + }, { + "val" : "MESH:D022423" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000764", "lbl" : "erythroid lineage cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A immature or mature cell in the lineage leading to and including erythrocytes.", + "xrefs" : [ "GOC:add", "GOC:tfm" ] + }, + "comments" : [ "Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes." ], + "xrefs" : [ { + "val" : "CALOHA:TS-0290" + }, { + "val" : "FMA:62845" + }, { + "val" : "FMA:83516" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000765", "lbl" : "erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.", + "xrefs" : [ "GOC:add", "ISBN:0721601464", "PMID:18174176" ] + }, + "xrefs" : [ { + "val" : "BTO:0001571" + }, { + "val" : "CALOHA:TS-0289" + }, { + "val" : "FMA:83504" + }, { + "val" : "MESH:D004900" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000766", "lbl" : "myeloid leukocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the monocyte, granulocyte, or mast cell lineage.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000778", "lbl" : "mononuclear osteoclast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts.", + "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:12713016", "PMID:15055519", "PMID:17380158", "PMID:9415452" ] + }, + "comments" : [ "Morphology: mononuclear, highly vesicular." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000779", "lbl" : "multinuclear osteoclast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized multinuclear osteoclast associated with the absorption and removal of bone.", + "xrefs" : [ "GOC:add", "PMID:12713016", "PMID:9415452" ] + }, + "comments" : [ "Morphology: multinucleated, highly vesicular." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000782", "lbl" : "myeloid dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dendritic cell of the myeloid lineage.", + "xrefs" : [ "GOC:add", "PMID:10449155", "PMID:17332250", "PMID:9521319" ] + }, + "comments" : [ "These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8)." ], + "xrefs" : [ { + "val" : "BTO:0004721" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000783", "lbl" : "multinucleated phagocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A phagocyte formed by the fusion of mononuclear phagocytes.", + "xrefs" : [ "GOC:add", "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000827", "lbl" : "pro-T cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000835", "lbl" : "myeloblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow.", + "xrefs" : [ "GOC:add", "ISBN:0721601464", "http://en.wikipedia.org/wiki/Myeloblast", "http://www.cap.org" ] + }, + "xrefs" : [ { + "val" : "BTO:0000187" + }, { + "val" : "FMA:83524" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000837", "lbl" : "hematopoietic multipotent progenitor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans.", + "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:19022770" ] + }, + "comments" : [ "Markers differ between mouse and human." ], + "xrefs" : [ { + "val" : "BTO:0000725" + }, { + "val" : "CALOHA:TS-0448" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000838", "lbl" : "lymphoid lineage restricted progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell restricted to the lymphoid lineage.", + "xrefs" : [ "GOC:add", "GOC:tfm" ] + }, + "comments" : [ "Note that this is a class of cell types, not an identified single cell type." ], + "xrefs" : [ { + "val" : "BTO:0004731" + }, { + "val" : "CALOHA:TS-2025" + }, { + "val" : "FMA:70338" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000839", "lbl" : "myeloid lineage restricted progenitor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A progenitor cell restricted to the myeloid lineage.", + "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:19022770" ] + }, + "comments" : [ "Note that this is a class of cell types, not an identified single cell type." ], + "xrefs" : [ { + "val" : "BTO:0004730" + }, { + "val" : "CALOHA:TS-2099" + }, { + "val" : "FMA:70339" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000842", "lbl" : "mononuclear cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A leukocyte with a single non-segmented nucleus in the mature form.", + "xrefs" : [ "GOC:add" ] + }, + "xrefs" : [ { + "val" : "BTO:0000878" + }, { + "val" : "CALOHA:TS-0768" + }, { + "val" : "FMA:86713" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000860", "lbl" : "classical monocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes.", + "xrefs" : [ "GOC:add", "GO_REF:0000031", "PMID:16322748", "PMID:18303997", "PMID:20628149", "PMID:20870168" ] + }, + "comments" : [ "Markers: CCR2+CXCCR1 (human, mouse, rat)." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000861", "lbl" : "elicited macrophage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive.", + "xrefs" : [ "GOC:add", "GOC:ana", "GOC:tfm", "GO_REF:0000031", "PMID:15771589" ] + }, + "comments" : [ "Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response)." ], + "xrefs" : [ { + "val" : "FMA:84643" + }, { + "val" : "FMA:84645" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000862", "lbl" : "suppressor macrophage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macrophage that suppresses immune responses.", + "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:20402419" ] + }, + "comments" : [ "Markers: May express: IL10, TGFbeta." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000864", "lbl" : "tissue-resident macrophage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.", + "xrefs" : [ "GOC:ana", "GO_REF:0000031", "PMID:19770654" ] + }, + "xrefs" : [ { + "val" : "FMA:84642" + }, { + "val" : "FMA:84644" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000878", "lbl" : "central nervous system macrophage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tissue-resident macrophage found in the central nervous system.", + "xrefs" : [ "GO_REF:0000031", "PMID:16322748" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000936", "lbl" : "early lymphoid progenitor", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative.", + "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19022770" ] + }, + "comments" : [ "Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000988", "lbl" : "hematopoietic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of a hematopoietic lineage.", + "xrefs" : [ "GOC:add", "GO_REF:0000031" ] + }, + "xrefs" : [ { + "val" : "BTO:0000574" + }, { + "val" : "CALOHA:TS-2017" + }, { + "val" : "FMA:70366" + }, { + "val" : "FMA:83598" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000990", "lbl" : "conventional dendritic cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Conventional dendritic cell is a dendritic cell that is CD11c-high.", + "xrefs" : [ "GOC:amm", "GO_REF:0000031", "PMID:17850486" ] + }, + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive." ], + "xrefs" : [ { + "val" : "FMA:84191" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000995", "lbl" : "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001008", "lbl" : "Kit and Sca1-positive hematopoietic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative.", + "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17952047", "PMID:19022770" ] + }, + "comments" : [ "Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001012", "lbl" : "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001019", "lbl" : "CD115-positive monocyte OR common dendritic progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001021", "lbl" : "CD34-positive, CD38-positive common lymphoid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive.", + "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585", "PMID:19022770" ] + }, + "comments" : [ "These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001022", "lbl" : "CD115-positive monocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive.", + "xrefs" : [ "GOC:add", "GOC:amm", "GO_REF:0000031", "PMID:17952047" ] + }, + "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001023", "lbl" : "Kit-positive, CD34-positive common myeloid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low.", + "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:1261582", "PMID:17952047", "http://www.immgen.org/index_content.html" ] + }, + "comments" : [ "Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001024", "lbl" : "CD34-positive, CD38-negative hematopoietic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive.", + "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:10430905", "PMID:11750107", "PMID:16551251", "PMID:20024907", "PMID:9389721" ] + }, + "comments" : [ "Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617)." ], + "xrefs" : [ { + "val" : "CALOHA:TS-0448" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001025", "lbl" : "Kit-positive, Sca1-positive common lymphoid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low.", + "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17952047", "http://www.immgen.org/index_content.html" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001026", "lbl" : "CD34-positive, CD38-positive common myeloid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative.", + "xrefs" : [ "GOC:add", "GOC:amm", "GO_REF:0000031", "PMCID:PMC2626675", "PMID:16551251" ] + }, + "comments" : [ "Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001027", "lbl" : "CD7-negative lymphoid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative.", + "xrefs" : [ "GOC:amm", "GO_REF:0000031", "PMID:16551251" ] + }, + "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001028", "lbl" : "CD7-positive lymphoid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative.", + "xrefs" : [ "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:19491395" ] + }, + "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001029", "lbl" : "common dendritic progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers.", + "xrefs" : [ "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:17922016", "PMID:19286519" ] + }, + "comments" : [ "Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001030", "lbl" : "CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001035", "lbl" : "bone cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A connective tissue cell found in bone.", + "xrefs" : [ "GOC:add", "GO_REF:0000034" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001054", "lbl" : "CD14-positive monocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20.", + "xrefs" : [ "GOC:add", "PMID:22343568" ] + }, + "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001059", "lbl" : "common myeloid progenitor, CD34-positive", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1.", + "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0878932437", "PMCID:PMC2212039", "PMID:10724173", "PMID:16551251", "PMID:16647566" ] + }, + "comments" : [ "CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001060", "lbl" : "hematopoietic oligopotent progenitor cell, lineage-negative", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers.", + "xrefs" : [ "GOC:tfm", "PMID:19022770" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001066", "lbl" : "erythroid progenitor cell, mammalian", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative).", + "xrefs" : [ "GOC:add", "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "BTO:0004911" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002000", "lbl" : "Kit-positive erythroid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084", "http://www.immgen.org/index_content.html" ] + }, + "comments" : [ "Markers found on mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002001", "lbl" : "CD34-positive, CD38-positive granulocyte monocyte progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative.", + "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:19022770" ] + }, + "comments" : [ "Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002002", "lbl" : "Kit-positive granulocyte monocyte progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative.", + "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:16322423", "PMID:19022770", "PMID:19273628", "http://www.immgen.org/index_content.html" ] + }, + "comments" : [ "Markers are found on mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002003", "lbl" : "CD34-positive, GlyA-negative erythroid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An erythroid progenitor cell that is CD34-positive and is GlyA-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19621348" ] + }, + "comments" : [ "Cell markers associated with human cells." ], + "xrefs" : [ { + "val" : "FMA:83517" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002004", "lbl" : "CD34-negative, GlyA-negative proerythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A proerythoblast that is CD34-negative and GlyA-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19621348" ] + }, + "comments" : [ "Cell surface markers are associated with human cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002005", "lbl" : "CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative.", + "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:190227700" ] + }, + "comments" : [ "Markers are associated with human cell type." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002006", "lbl" : "Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low.", + "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:19022770", "http://www.immgen.org/index_content.html" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002009", "lbl" : "macrophage dendritic cell progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages.", + "xrefs" : [ "GOC:tfm", "PMID:19273628" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002010", "lbl" : "pre-conventional dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002011", "lbl" : "Kit-positive macrophage dendritic cell progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative.", + "xrefs" : [ "GOC:tfm", "PMID:19273628" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002012", "lbl" : "Kit-low proerythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002013", "lbl" : "GlyA-positive basophilic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A basophilic erythroblast that is GlyA-positive.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:1638021" ] + }, + "comments" : [ "Markers are associated with human cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002014", "lbl" : "Kit-negative, Ly-76 high basophilic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A basophilic erythroblast that is Lyg 76-high and is Kit-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] + }, + "comments" : [ "Cell surface markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002015", "lbl" : "Kit-negative, Ly-76 high polychromatophilic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002016", "lbl" : "CD71-low, GlyA-positive polychromatic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A polychromatiic erythroblast that is Gly-A-positive and CD71-low.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:1638021" ] + }, + "comments" : [ "Cell surface markers are associated with human cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002017", "lbl" : "Kit-negative, Ly-76 high orthochromatophilic erythroblasts", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] + }, + "comments" : [ "Cell surface markers associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002018", "lbl" : "CD71-negative, GlyA-positive orthochromatic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An erythroblast that is GlyA-positive and CD71-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:1638021" ] + }, + "comments" : [ "Markers associated with human cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002031", "lbl" : "hematopoietic lineage restricted progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells.", + "xrefs" : [ "GOC:tfm", "PMID:19022770" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002032", "lbl" : "hematopoietic oligopotent progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities.", + "xrefs" : [ "GOC:tfm", "PMID:19022770", "https://orcid.org/0000-0001-5208-3432" ] + }, + "comments" : [ "This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002033", "lbl" : "short term hematopoietic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative.", + "xrefs" : [ "GOC:tfm", "PMID:15572596", "PMID:19022770" ] + }, + "comments" : [ "Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002034", "lbl" : "long term hematopoietic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative.", + "xrefs" : [ "GOC:tfm", "PMID:15572596", "PMID:17582345" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002035", "lbl" : "Slamf1-negative multipotent progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative.", + "xrefs" : [ "GOC:tfm", "PMID:19022770" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002036", "lbl" : "Slamf1-positive multipotent progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive.", + "xrefs" : [ "GOC:tfm", "PMID:19022770" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002043", "lbl" : "CD34-positive, CD38-negative multipotent progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative.", + "xrefs" : [ "GOC:tfm", "PMID:18371405", "PMID:19022770" ] + }, + "comments" : [ "Cell markers are associated with human hematopoietic multipotent progenitor cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002062", "lbl" : "pulmonary alveolar type 1 cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange.", + "xrefs" : [ "GOC:tfm", "PMID:20054144", "PMID:29463737", "http://www.copewithcytokines.de" ] + }, + "xrefs" : [ { + "val" : "BTO:0000780" + }, { + "val" : "FMA:62500" } ] } }, { @@ -1518,87 +3613,286 @@ "lbl" : "pulmonary alveolar type 2 cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli.", + "xrefs" : [ "GOC:tfm", "ISBN:0412046911", "PMID:36138472", "PMID:8540632", "http://www.copewithcytokines.de" ] + }, + "xrefs" : [ { + "val" : "BTO:0000538" + }, { + "val" : "FMA:62501" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002064", + "lbl" : "pancreatic acinar cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "PMID:20395539", "http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells" ] + }, + "xrefs" : [ { + "val" : "BTO:0000028" + }, { + "val" : "CALOHA:TS-0737" + }, { + "val" : "FMA:63032" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002067", "lbl" : "type A enteroendocrine cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An enteroendocrine cell that produces glucagon.", + "xrefs" : [ "GOC:tfm", "ISBN:0412046911" ] + }, + "xrefs" : [ { + "val" : "FMA:62939" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002068", "lbl" : "Purkinje myocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter.", + "xrefs" : [ "FMA:0412046911", "GOC:tfm", "PMID:19939742" ] + }, + "xrefs" : [ { + "val" : "BTO:0001032" + }, { + "val" : "FMA:14146" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002072", "lbl" : "nodal myocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery.", + "xrefs" : [ "FMA:67101", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004190" + }, { + "val" : "FMA:67101" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002073", "lbl" : "transitional myocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes.", + "xrefs" : [ "FMA:67142", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67142" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002074", "lbl" : "myocardial endocrine cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides).", + "xrefs" : [ "FMA:67111", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67111" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002076", "lbl" : "endo-epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell derived from endoderm.", + "xrefs" : [ "FMA:69075", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:69075" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002077", "lbl" : "ecto-epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell derived from ectoderm.", + "xrefs" : [ "FMA:69074", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:69074" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002078", "lbl" : "meso-epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial cell derived from mesoderm or mesenchyme.", + "xrefs" : [ "FMA:69076", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:69076" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002079", + "lbl" : "pancreatic ductal cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH.", + "xrefs" : [ "FMA:63099", "GOC:tfm", "PMID:14740223" ] + }, + "xrefs" : [ { + "val" : "FMA:63099" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002080", + "lbl" : "pancreatic centro-acinar cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types.", + "xrefs" : [ "GOC:tfm", "PMID:12142741", "PMID:20018761", "PMID:8185160" ] + }, + "xrefs" : [ { + "val" : "FMA:62455" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002086", "lbl" : "specialized cardiac myocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart.", + "xrefs" : [ "FMA:67968", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67968" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002087", "lbl" : "nongranular leukocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A leukocyte that lacks granules.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:62855" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002088", + "lbl" : "interstitial cell of Cajal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise.", + "xrefs" : [ "GOC:tfm", "PMID:16460275", "PMID:19520112" ] + }, + "comments" : [ "Some argue this cell type is of mesenchymal origin." ], + "xrefs" : [ { + "val" : "BTO:0003914" + }, { + "val" : "FMA:86573" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002092", "lbl" : "bone marrow cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells.", + "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ] + }, + "comments" : [ "MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense." ], + "xrefs" : [ { + "val" : "BTO:0004850" + }, { + "val" : "FMA:83621" + }, { + "val" : "MESH:D001854" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002095", "lbl" : "hilus cell of ovary", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell in the hilum of the ovary that produces androgens.", + "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ] + }, + "xrefs" : [ { + "val" : "FMA:18710" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002132", "lbl" : "stromal cell of ovary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stomal cell of the ovary", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:72299" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002139", "lbl" : "endothelial cell of vascular tree", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.", + "xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ] + }, + "comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive." ], + "xrefs" : [ { + "val" : "BTO:0001854" + }, { + "val" : "CALOHA:TS-1106" + }, { + "val" : "FMA:67755" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002144", "lbl" : "capillary endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell found in capillaries.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004956" + }, { + "val" : "CALOHA:TS-0112" + }, { + "val" : "FMA:67756" } ] } }, { @@ -1606,415 +3900,1203 @@ "lbl" : "ciliated columnar cell of tracheobronchial tree", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ] + }, + "xrefs" : [ { + "val" : "FMA:70542" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002159", "lbl" : "general ecto-epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial cells derived from general body ectoderm and ectoderm placodes.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70556" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002178", "lbl" : "epithelial cell of stomach", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell found in the lining of the stomach.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:62948" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002180", "lbl" : "mucous cell of stomach", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucous cell in the epithelium of the stomach.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:63464" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002183", "lbl" : "stem cell of gastric gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ] + }, + "xrefs" : [ { + "val" : "FMA:62953" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002191", "lbl" : "granulocytopoietic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell involved in the formation of a granulocyte.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83519" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002194", "lbl" : "monopoietic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell involved in the formation of a monocyte (monopoiesis).", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83552" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002195", + "lbl" : "hepatic stem cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes).", + "xrefs" : [ "GOC:tfm", "PMID:26798363" ] + }, + "xrefs" : [ { + "val" : "FMA:86577" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002202", "lbl" : "epithelial cell of tracheobronchial tree", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the tracheobronchial tree.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:66816" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002209", "lbl" : "intermediate epitheliocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ] + }, + "xrefs" : [ { + "val" : "FMA:69060" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002222", "lbl" : "vertebrate lens cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "FMA:70950" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002224", "lbl" : "lens epithelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544", "http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium" ] + }, + "xrefs" : [ { + "val" : "FMA:67559" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002240", "lbl" : "marrow fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast in the bone marrow.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:84377" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002241", "lbl" : "pulmonary interstitial fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:84467" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002242", "lbl" : "nucleate cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell containing at least one nucleus.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67513" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002243", + "lbl" : "smooth muscle cell of sphincter of pupil", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544", "ISBN:0721694128" ] + }, + "xrefs" : [ { + "val" : "FMA:70611" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002246", "lbl" : "peripheral blood stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells).", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0002669" + }, { + "val" : "FMA:86711" + }, { + "val" : "MESH:D000072916" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002251", "lbl" : "epithelial cell of alimentary canal", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002252", "lbl" : "epithelial cell of esophagus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the esophagus.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:63071" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002253", + "lbl" : "epithelial cell of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the large intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004297" + }, { + "val" : "FMA:256157" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002254", + "lbl" : "epithelial cell of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the small intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:256159" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002262", "lbl" : "endothelial cell of sinusoid", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver.", + "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ] + }, + "xrefs" : [ { + "val" : "FMA:63134" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002264", "lbl" : "type A cell of stomach", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A type of enteroendocrine cell found in the stomach that secretes glucagon.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83411" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002265", + "lbl" : "type D cell of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A D cell located in the colon.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:268744" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002266", + "lbl" : "type D cell of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A type D cell of the small intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:268736" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002267", + "lbl" : "type D cell of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A type D cell found in the stomach.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83410" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002275", + "lbl" : "pancreatic PP cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A PP cell located in the islets of the pancreas.", + "xrefs" : [ "GOC:tfm" ] + }, + "comments" : [ "The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell." ], + "xrefs" : [ { + "val" : "BTO:0000805" + }, { + "val" : "FMA:70588" + }, { + "val" : "MESH:D050418" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002308", "lbl" : "epithelial cell of skin gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of a skin gland.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70657" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002319", "lbl" : "neural cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that is part of the nervous system.", + "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2040" + }, { + "val" : "FMA:70333" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002320", "lbl" : "connective tissue cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.", + "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2096" + }, { + "val" : "FMA:63875" + }, { + "val" : "MESH:D003239" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002321", "lbl" : "embryonic cell (metazoa)", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the embryo.", + "xrefs" : [ "FMA:0618947256" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0263" + }, { + "val" : "FMA:82840" + }, { + "val" : "WBbt:0007028" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002328", "lbl" : "bronchial epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the bronchus.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0002922" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002332", "lbl" : "ciliated cell of the bronchus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A ciliated cell of the bronchus.", + "xrefs" : [ "GOC:tfm", "PMID:18757316" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002333", "lbl" : "neural crest derived adipocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipocyte derived from a neural crest cell.", + "xrefs" : [ "GOC:tfm", "PMID:17507398" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002350", "lbl" : "endocardial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin.", + "xrefs" : [ "GOC:tfm", "ISSN:0452-3458" ] + }, + "xrefs" : [ { + "val" : "FMA:75621" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002351", + "lbl" : "progenitor cell of endocrine pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1.", + "xrefs" : [ "GOC:tfm", "PMID:20025937", "PMID:20217494", "PMID:22728667" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002352", "lbl" : "gestational hematopoietic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic stem cell that exists during embryogenesis.", + "xrefs" : [ "GOC:tfm", "ISBN:978-60327-246-6" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002363", "lbl" : "keratocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate.", + "xrefs" : [ "GOC:tfm", "ISBN:9780702029585" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002368", "lbl" : "respiratory epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endo-epithelial cell of the respiratory tract.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004533" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002372", "lbl" : "myotube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts.", + "xrefs" : [ "GOC:dos", "GOC:tfm", "ISBN:0323052908", "PMID:22274696" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002397", "lbl" : "CD14-positive, CD16-positive monocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A CD14-positive monocyte that is also CD16-positive and CCR2-negative.", + "xrefs" : [ "GOC:tfm", "PMID:20628149", "PMID:21937707", "PMID:22343568" ] + }, + "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002421", "lbl" : "nucleated reticulocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles.", + "xrefs" : [ "GOC:tfm", "PMID:18182572", "PMID:9011180", "PMID:9046052" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002454", "lbl" : "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive.", + "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002462", "lbl" : "adipose dendritic cell", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/CL_0002463", - "lbl" : "SIRPa-positive adipose dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A F4/80-negative dendritic cell located in adipose tissue.", + "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002463", + "lbl" : "SIRPa-positive adipose dendritic cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipose dendritic cell that is SIRPa-positive.", + "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002464", "lbl" : "SIRPa-negative adipose dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipose dendritic cell that is SIRPa-negative.", + "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002465", "lbl" : "CD11b-positive dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A conventional dendritic cell that expresses CD11b (ITGAM).", + "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002494", "lbl" : "cardiocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell located in the heart, including both muscle and non muscle cells.", + "xrefs" : [ "GOC:tfm" ] + }, + "comments" : [ "From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart." ], + "xrefs" : [ { + "val" : "BTO:0001539" + }, { + "val" : "CALOHA:TS-0115" + }, { + "val" : "FMA:83808" + }, { + "val" : "FMA:84791" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002503", "lbl" : "adventitial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0002441" + }, { + "val" : "FMA:84639" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002504", + "lbl" : "enteric smooth muscle cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the intestine.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002521", "lbl" : "subcutaneous adipocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An adipocyte that is part of subcutaneous adipose tissue.", + "xrefs" : [ "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002538", + "lbl" : "intrahepatic cholangiocyte", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes.", + "xrefs" : [ "GOC:tfm", "PMID:23720296" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002539", "lbl" : "aortic smooth muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the aorta.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004577" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002540", "lbl" : "mesenchymal stem cell of the bone marrow", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal stem cell that is part of the bone marrow.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002543", "lbl" : "vein endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell that is part of the vein.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:62104" + }, { + "val" : "KUPO:0001099" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002546", "lbl" : "embryonic blood vessel endothelial progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial progenitor cell that participates in angiogenesis during development.", + "xrefs" : [ "GOC:tfm" ] + }, + "comments" : [ "See CL:0002619." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002547", "lbl" : "fibroblast of the aortic adventitia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast of the aortic adventitia.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002548", "lbl" : "fibroblast of cardiac tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast that is part of the heart.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002551", "lbl" : "fibroblast of dermis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any skin fibroblast that is part of some dermis.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002553", "lbl" : "fibroblast of lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast that is part of lung.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0000764" + }, { + "val" : "CALOHA:TS-0575" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002557", "lbl" : "fibroblast of pulmonary artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A fibroblast of pulmonary artery.", + "xrefs" : [ "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002563", + "lbl" : "intestinal epithelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the intestine.", + "xrefs" : [ "GOC:tfm" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002570", "lbl" : "mesenchymal stem cell of adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal stem cell of adipose tissue.", + "xrefs" : [ "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002571", + "lbl" : "hepatic mesenchymal stem cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal stem cell of liver.", + "xrefs" : [ "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002572", + "lbl" : "vertebral mesenchymal stem cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal stem cell of the vertebrae.", + "xrefs" : [ "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002574", + "lbl" : "stromal cell of pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stromal cell of the pancreas.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002575", "lbl" : "central nervous system pericyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pericyte of the central nervous system.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002585", "lbl" : "retinal blood vessel endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A blood vessel endothelial cell that is part of the retina.", + "xrefs" : [ "GOC:tfm" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002589", "lbl" : "smooth muscle cell of the brachiocephalic vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the bachiocephalic vasculature.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002590", "lbl" : "smooth muscle cell of the brain vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vascular associated smooth muscle cell of the brain vasculature.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002591", "lbl" : "smooth muscle cell of the pulmonary artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A smooth muscle of the pulmonary artery.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0003336" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002595", "lbl" : "smooth muscle cell of the subclavian artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the subclavian artery.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002596", "lbl" : "smooth muscle cell of the carotid artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Smooth muscle cell of the carotid artery.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002598", "lbl" : "bronchial smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Any smooth muscle cell that is part of some bronchus.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "BTO:0004402" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002599", "lbl" : "smooth muscle cell of the esophagus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the esophagus.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002600", "lbl" : "smooth muscle cell of trachea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the trachea.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002610", "lbl" : "raphe nuclei neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron of the raphe nuclei.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002612", "lbl" : "neuron of the ventral spinal cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron of the ventral spinal cord.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002620", "lbl" : "skin fibroblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A fibroblast of skin.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0001255" + }, { + "val" : "CALOHA:TS-0935" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002632", "lbl" : "epithelial cell of lower respiratory tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any epithelial cell that is part of some lower respiratory tract epithelium.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002653", "lbl" : "squamous endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A squamous shaped endothelial cell.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002657", "lbl" : "glandular cell of esophagus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A glandular epithelial cell of the esophagus.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:86548" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002658", + "lbl" : "glandular cell of the large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A glandular epithelial cell of the large intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:87194" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002659", "lbl" : "glandular cell of stomach", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A glandular epithelial cell that is part of the stomach.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1284" + }, { + "val" : "FMA:86554" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002663", "lbl" : "myocardial endocrine cell of atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myocardial endocrine cell that is part of the atrium.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83389" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002664", "lbl" : "cardioblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart.", + "xrefs" : [ "GOC:tfm", "PMID:19745164" ] + }, + "comments" : [ "Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002672", "lbl" : "retinal progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells.", + "xrefs" : [ "GOC:tfm", "PMID:20959166", "PMID:21148186" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002676", "lbl" : "neural crest derived neuroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuroblast derived from a neural crest cell.", + "xrefs" : [ "GOC:tfm", "PMID:17407019" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002680", + "lbl" : "PP cell of intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A PP cell found in intestine.", + "xrefs" : [ "GOC:tfm", "PMID:2420136", "PMID:728970" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0005000", "lbl" : "spinal cord interneuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A CNS interneuron located in the spinal cord.", + "xrefs" : [ "CL:CVS" ] + }, + "comments" : [ "Is_a interneuron, part_of UBERON:0002240." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0005012", "lbl" : "multi-ciliated epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ciliated epithelial cell with many cilia.", + "xrefs" : [ "CL:CVS" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0005026", + "lbl" : "hepatoblast", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation.", + "xrefs" : [ "GOC:CVS", "PMID:18356246", "PMID:20483998", "PMID:26798363", "https://orcid.org/0000-0003-1940-6740" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0007001", "lbl" : "skeletogenic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized).", + "xrefs" : [ "GO_REF:0000034" ] + }, + "comments" : [ "Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0007004", "lbl" : "premigratory neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells.", + "xrefs" : [ "UBERONREF:0000002" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0007009", "lbl" : "prechondroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells.", + "xrefs" : [ "GO_REF:0000034" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008000", "lbl" : "non-striated muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle cell in which the fibers are not organised into sarcomeres.", + "xrefs" : [ "GOC:DOS" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008001", "lbl" : "hematopoietic precursor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any hematopoietic cell that is a precursor of some other hematopoietic cell type.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008002", "lbl" : "skeletal muscle fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:tfm", "ISBN:0323052908" ] + }, + "xrefs" : [ { + "val" : "MESH:D018485" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008007", "lbl" : "visceral muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle cell that is part of some visceral muscle.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008008", "lbl" : "striated visceral muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008009", "lbl" : "transversely striated visceral muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008017", "lbl" : "adult skeletal muscle myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers.", + "xrefs" : [ "PMID:23303905" ] + }, + "comments" : [ "The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008019", "lbl" : "mesenchymal cell", @@ -2022,38 +5104,68 @@ "meta" : { "definition" : { "val" : "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008022", "lbl" : "endocardial cushion cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves.", + "xrefs" : [ "PMID:18816864" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0008024", + "lbl" : "pancreatic endocrine cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endocrine cell that is part of the pancreas.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008028", "lbl" : "visual system neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neuron that is capable of part of some visual perception.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008034", "lbl" : "mural cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation.", + "xrefs" : [ "Wiki:Mural_cell&oldid=930603194" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008035", "lbl" : "microcirculation associated smooth muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009000", "lbl" : "sensory neuron of spinal nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord.", + "xrefs" : [ "GOC:nv", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009001", "lbl" : "compound eye retinal cell", @@ -2061,26 +5173,227 @@ "meta" : { "definition" : { "val" : "Any cell in the compound eye, a light sensing organ composed of ommatidia." - } + }, + "xrefs" : [ { + "val" : "GOC:pr" + }, { + "val" : "PMID:12021768" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009004", "lbl" : "retinal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.", + "xrefs" : [ "GOC:pr" ] + }, + "xrefs" : [ { + "val" : "PMID:10702418" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009006", + "lbl" : "enteroendocrine cell of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An enteroendocrine cell that is located in the small intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009018", + "lbl" : "lymphocyte of large intestine lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lymphocyte that resides in the lamina propria of the large intestine.", + "xrefs" : [ "https://orcid.org/0000-0003-4183-8865" ] + }, + "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009021", + "lbl" : "stromal cell of lamina propria of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stromal cell found in the lamina propria of the large intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009022", + "lbl" : "stromal cell of lamina propria of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stromal cell found in the lamina propria of the small intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009024", + "lbl" : "mesothelial cell of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the small intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009025", + "lbl" : "mesothelial cell of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009038", + "lbl" : "colon macrophage", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macrophage that is located in the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + }, + "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009040", + "lbl" : "stromal cell of lamina propria of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stromal cell found in the lamina propria of the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009042", + "lbl" : "enteroendocrine cell of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An enteroendocrine cell that is located in the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009044", + "lbl" : "lymphocyte of small intestine lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response.", + "xrefs" : [ "PMID:26551552", "https://orcid.org/0000-0003-4183-8865" ] + }, + "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009048", + "lbl" : "anorectum macrophage", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macrophage that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + }, + "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009051", + "lbl" : "T cell of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A T cell that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + }, + "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009052", + "lbl" : "smooth muscle cell of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009053", + "lbl" : "stromal cell of anorectum lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stromal cell found in the lamina propria of the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009063", + "lbl" : "enteroendocrine cell of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An enteroendocrine cell that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009089", "lbl" : "lung pericyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A pericyte cell that is part of a lung.", + "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ] + }, + "xrefs" : [ { + "val" : "EFO:0010669" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009094", + "lbl" : "endothelial cell of hepatic portal vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell that is part of a hepatic portal vein.", + "xrefs" : [ "PMID:30348985", "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ] + }, + "xrefs" : [ { + "val" : "EFO:0010704" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009097", "lbl" : "embryonic skeletal muscle fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development.", + "xrefs" : [ "PMID:32094117", "PMID:7196501", "http://orcid.org/0000-0003-2034-601X" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009100", + "lbl" : "hepatic portal fibroblast", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen.", + "xrefs" : [ "PMID:20209607", "PMID:24814904", "https://orcid.org/0000-0001-7655-4833" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010001", "lbl" : "stromal cell of bone marrow", @@ -2097,7 +5410,11 @@ "meta" : { "definition" : { "val" : "An epithelial cell that is part_of a alveolus of lung." - } + }, + "comments" : [ "May be merged with pneumocyte in future" ], + "xrefs" : [ { + "val" : "MESH:D056809" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010004", @@ -2111,25 +5428,43 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0010006", "lbl" : "cardiac blood vessel endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any blood vessel endothelial cell that is part of some heart.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010007", "lbl" : "His-Purkinje system cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that is part of some His-Purkinje system.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010008", "lbl" : "cardiac endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any endothelial cell that is part of some heart.", + "xrefs" : [ "FBC:Autogenerated" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010009", "lbl" : "camera-type eye photoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any photoreceptor cell that is part of some camera-type eye.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010017", "lbl" : "zygote", @@ -2137,32 +5472,75 @@ "meta" : { "definition" : { "val" : "A zygote in a plant or an animal." - } + }, + "xrefs" : [ { + "val" : "MESH:D015053" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010020", "lbl" : "cardiac glial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any glial cell that is part of some heart.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010021", "lbl" : "cardiac myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any myoblast that develops into some cardiac muscle cell.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "MESH:D032386" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010022", "lbl" : "cardiac neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron that has its soma in the heart.", + "xrefs" : [ "PMID:12486170", "PMID:29265764" ] + }, + "comments" : [ "This term is used in 3 GO terms that were created as part of the heart development focus project." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011001", "lbl" : "spinal cord motor neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.", + "xrefs" : [ "GOC:nv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011007", "lbl" : "paraxial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites.", + "xrefs" : [ "GOC:NV", "PMID:11687492" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011012", "lbl" : "neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.", + "xrefs" : [ "https://orcid.org/0000-0001-5208-3432", "https://orcid.org/0000-0002-9900-7880" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011019", "lbl" : "mesothelial cell of epicardium", @@ -2193,35 +5571,94 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0011026", "lbl" : "progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses.", + "xrefs" : [ "ISBN:978-1-62808-994-3", "https://doi.org/10.1016/B978-0-12-409503-8.00002-0" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011027", "lbl" : "skeletal muscle fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of skeletal muscle tissue.", + "xrefs" : [ "PMID:28369879", "https://orcid.org/0000-0001-6164-0667" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011030", "lbl" : "dermal microvascular endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microvascular endothelial cell that is part of the dermis.", + "xrefs" : [ "BTO:0004574", "CL:patterns/cellPartOfAnatomicalEntity" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0011108", + "lbl" : "colon epithelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial cell that is part of the colon epithelium.", + "xrefs" : [ "GOC:NV" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011115", "lbl" : "precursor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that, by division or terminal differentiation, can give rise to other cell types.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0017500", "lbl" : "neutrophillic cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0017502", "lbl" : "acidophilic cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0017503", "lbl" : "basophilic cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0017504", "lbl" : "polychromatophilic cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0019001", "lbl" : "tracheobronchial serous cell", @@ -2238,102 +5675,275 @@ "meta" : { "definition" : { "val" : "Any chondrocyte that is part of the tracheobronchial tree." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0019018", "lbl" : "blood vessel smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A smooth muscle cell that is part of any blood vessel.", + "xrefs" : [ "PMID:9108778" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0019019", "lbl" : "tracheobronchial smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A smooth muscle cell that is part of the tracheobronchial tree.", + "xrefs" : [ "PMID:10853867" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0019020", + "lbl" : "extrahepatic cholangiocyte", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes.", + "xrefs" : [ "PMID:23720296" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0019021", + "lbl" : "endothelial cell of periportal hepatic sinusoid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid.", + "xrefs" : [ "PMID:27423426" ] + }, + "xrefs" : [ { + "val" : "EFO:0010705" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0019022", + "lbl" : "endothelial cell of pericentral hepatic sinusoid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid.", + "xrefs" : [ "PMID:27423426" ] + }, + "xrefs" : [ { + "val" : "EFO:0010706" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000222", "lbl" : "stomach neuroendocrine cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neuroendocrine cell that is part of some stomach.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000223", "lbl" : "lung neuroendocrine cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury.", + "xrefs" : [ "PMID:33355253", "doi:10.3109/01902148209069653", "doi:10.7554/eLife.78216" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000271", "lbl" : "lung ciliated cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any ciliated cell that is part of some lung.", + "xrefs" : [ "FBC:Autogenerated" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000272", "lbl" : "lung secretory cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is part of some lung.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000274", "lbl" : "trophectodermal cell", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000275", + "lbl" : "smooth muscle cell of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the small intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:15050" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000276", + "lbl" : "smooth muscle fiber of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the duodenum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:15058" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000279", + "lbl" : "smooth muscle cell of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the large intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:15653" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000280", + "lbl" : "smooth muscle cell of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the colon.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:15663" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000285", + "lbl" : "smooth muscle cell of sigmoid colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the sigmoid colon.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:17521" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000286", + "lbl" : "smooth muscle cell of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the rectum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:17522" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000303", "lbl" : "fibroblast of areolar connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast that is part of the areolar connective tissue.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261279" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000306", "lbl" : "fibroblast of tunica adventitia of artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast that is part of the tunica adventitia of artery.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261285" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000307", "lbl" : "fibroblast of dense regular elastic tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast that is part of the dense regular elastic tissue.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261287" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000309", "lbl" : "epicardial adipocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An adipocyte that is part of the epicardial fat.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261293" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000310", "lbl" : "adipocyte of epicardial fat of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipocyte that is part of the epicardial fat of right ventricle.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261297" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000311", "lbl" : "adipocyte of epicardial fat of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipocyte that is part of the epicardial fat of left ventricle.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261300" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000330", "lbl" : "serous cell of epithelium of trachea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A serous secreting cell that is part of the epithelium of trachea.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263078" } ] } }, { @@ -2341,43 +5951,120 @@ "lbl" : "serous cell of epithelium of bronchus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A serous secreting cell that is part of the epithelium of bronchus.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263080" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000332", "lbl" : "serous cell of epithelium of terminal bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous secreting cell that is part of the epithelium of terminal bronchiole.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263082" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000361", "lbl" : "transitional myocyte of interatrial septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transitional myocyte that is part of the interatrial septum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263152" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000362", "lbl" : "transitional myocyte of interventricular septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transitional myocyte that is part of the interventricular septum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263154" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000376", "lbl" : "Purkinje myocyte of interventricular septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A Purkinje myocyte that is part of the interventricular septum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263182" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000398", + "lbl" : "endothelial cell of hepatic sinusoid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates.", + "xrefs" : [ "GOC:tfm", "PMID:3926620" ] + }, + "xrefs" : [ { + "val" : "BTO:000125" + }, { + "val" : "FMA:62911" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000409", "lbl" : "myocyte of sinoatrial node", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle cell that is part of the sinoatrial node.", + "xrefs" : [ "FMA:67102", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67102" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000410", "lbl" : "myocyte of atrioventricular node", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle cell that is part of the atrioventricular node.", + "xrefs" : [ "FMA:67106", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67106" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000412", "lbl" : "endothelial cell of arteriole", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell that is part of the arteriole.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67760" + }, { + "val" : "KUPO:0001097" } ] } }, { @@ -2385,9 +6072,16 @@ "lbl" : "endothelial cell of artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A blood vessel endothelial cell that is part of an arterial endothelium.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004758" + }, { + "val" : "FMA:67761" + }, { + "val" : "KUPO:0001095" } ] } }, { @@ -2395,251 +6089,753 @@ "lbl" : "endothelial cell of venule", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell that is part of the venule.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67762" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000415", + "lbl" : "epithelial cell of gallbladder", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell that is part of the gallbladder.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67780" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000428", "lbl" : "stem cell of epidermis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A somatic stem cell that is part of the epidermis.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70541" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000443", "lbl" : "ciliary muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the ciliary body.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70610" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000444", "lbl" : "mesothelial cell of anterior chamber of eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the anterior chamber of eyeball.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70615" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000456", "lbl" : "mesothelial cell of parietal peritoneum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the parietal peritoneum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:72142" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000457", "lbl" : "mesothelial cell of visceral peritoneum", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mesothelial cell that is part of the visceral peritoneum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:72143" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000478", "lbl" : "transitional myocyte of sinoatrial node", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transitional myocyte that is part of the sinoatrial node.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83384" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000479", "lbl" : "Purkinje myocyte of atrioventricular node", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A Purkinje myocyte that is part of the atrioventricular node.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83386" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000482", "lbl" : "myocardial endocrine cell of interventricular septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myocardial endocrine cell that is part of the interventricular septum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83390" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000488", + "lbl" : "cholangiocyte", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.", + "xrefs" : [ "GOC:tfm", "PMID:16550043", "PMID:18356246" ] + }, + "xrefs" : [ { + "val" : "FMA:86481" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000490", "lbl" : "mesothelial cell of peritoneum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the peritoneum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:86736" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000491", "lbl" : "mesothelial cell of pleura", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the pleura.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:86737" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000492", "lbl" : "mesothelial cell of parietal pleura", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the parietal pleura.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:86738" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000493", "lbl" : "mesothelial cell of visceral pleura", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mesothelial cell that is part of the visceral pleura.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:86739" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001433", + "lbl" : "epithelial cell of exocrine pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the exocrine pancreas.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70986" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001516", + "lbl" : "intestinal enteroendocrine cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract.", + "xrefs" : [ "MP:0010802" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001567", "lbl" : "lung endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any endothelial cell of vascular tree that is part of some lung.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001568", "lbl" : "pulmonary artery endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Any endothelial cell of vascular tree that is part of some pulmonary artery.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "BTO:0001141" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001572", + "lbl" : "colon endothelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vascular endothelial cell found in colon blood vessels.", + "xrefs" : [ "NPX:PDR", "https://orcid.org/0000-0001-5208-3432" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2397" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001576", "lbl" : "oral mucosa squamous cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Squamous cell of oral epithelium.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1252" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001588", + "lbl" : "colon glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1274" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001589", + "lbl" : "duodenum glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1275" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001592", + "lbl" : "gallbladder glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Glandular cell of gallbladder epithelium.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1278" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001595", + "lbl" : "rectum glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1281" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001598", + "lbl" : "small intestine glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) .", + "xrefs" : [ "NCI_Thesaurus:Small_Intestinal_Glandular_Cell", "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1286" + }, { + "val" : "FMA:86928" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001599", + "lbl" : "pancreas exocrine glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts.", + "xrefs" : [ "HPA:HPA", "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "BTO:0000028" + }, { + "val" : "CALOHA:TS-1242" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001603", "lbl" : "lung macrophage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung.", + "xrefs" : [ "HPA:HPA", "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0576" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001609", "lbl" : "muscle fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fibroblast from muscle organ.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0643" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001610", "lbl" : "bone marrow hematopoietic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2109" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000001", "lbl" : "peripheral blood mononuclear cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000008", "lbl" : "microvascular endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any blood vessel endothelial cell that is part of a microvascular endothelium.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000010", "lbl" : "dermis blood vessel endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any blood vessel endothelial cell that is part of a dermis.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000013", "lbl" : "fibroblast of skin of abdomen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any skin fibroblast that is part of a skin of abdomen.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000016", "lbl" : "lung microvascular endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any lung endothelial cell that is part of a microvascular endothelium.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000019", "lbl" : "compound eye photoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any photoreceptor cell that is part of a compound eye.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000020", "lbl" : "inner cell mass cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any native cell that is part of a inner cell mass.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000022", "lbl" : "cardiac septum cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any native cell that is part of a cardiac septum.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000029", "lbl" : "central nervous system neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neuron that is part of a central nervous system.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000032", "lbl" : "peripheral nervous system neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A neuron that is part of a peripheral nervous system.", + "xrefs" : [ "GOC:TermGenie", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "FMA:84664" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000042", "lbl" : "embryonic fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a embryo.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000043", "lbl" : "brain pericyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any pericyte cell that is part of a brain.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000044", "lbl" : "brain microvascular endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microvascular endothelial cell that is part of a brain.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000046", "lbl" : "ventricular cardiac muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cardiac muscle cell that is part of a cardiac ventricle.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000047", "lbl" : "brainstem motor neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any motor neuron that is part of a brainstem.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_2000051", + "lbl" : "splenic fibroblast", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a spleen.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_2000053", + "lbl" : "splenic endothelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any endothelial cell that is part of a spleen.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=5500" ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_2000055", + "lbl" : "liver dendritic cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any dendritic cell that is part of a liver.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.jleukbio.org/content/66/2/322.abstract" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000063", "lbl" : "ovarian fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a female gonad.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=7330" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000064", "lbl" : "ovarian surface epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any epithelial cell that is part of a female gonad.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=7310" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000066", "lbl" : "cardiac ventricle fibroblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any fibroblast that is part of a cardiac ventricle.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=6310" ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000067", "lbl" : "cardiac atrium fibroblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any fibroblast that is part of a cardiac atrium.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=6320" ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000068", "lbl" : "pericardium fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a pericardium.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=6430" ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_2000069", + "lbl" : "gallbladder fibroblast", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a gallbladder.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=5430" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000070", "lbl" : "optic choroid fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a optic choroid.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=6620" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000072", "lbl" : "adipose microvascular endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microvascular endothelial cell that is part of a adipose tissue.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=7200" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000073", "lbl" : "migratory cardiac neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any migratory neural crest cell that is part of a cardiac neural crest.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_2000074", + "lbl" : "splenocyte", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any leukocyte that is part of a spleen.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000080", "lbl" : "mesenchymal stem cell of abdominal adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any mesenchymal stem cell of adipose tissue that is part of an abdomen.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000093", "lbl" : "bronchus fibroblast of lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast of lung that is part of a bronchus.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_3000000", "lbl" : "ciliated epithelial cell of esophagus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ciliated epithelial cell of the esophagus.", + "xrefs" : [ "GOC:CellBLAST", "PMID:29802404" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_3000004", "lbl" : "peripheral sensory neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Peripheral sensory neuron.", + "xrefs" : [ "GOC:CellBLAST", "PMID:30096314" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4023072", "lbl" : "brain vascular cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A cell that is part of the brain vasculature.", + "xrefs" : [ "DOI:10.1101/2022.10.12.511898" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_4023079", "lbl" : "midbrain-derived inhibitory neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A GABAergic inhibitory neuron that is derived from the midbrain.", + "xrefs" : [ "DOI:10.1101/2022.10.12.511898" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_4023168", "lbl" : "somatosensory neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli.", + "xrefs" : [ "PMID:22865660" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4028001", "lbl" : "pulmonary capillary endothelial cell", @@ -2654,87 +6850,165 @@ "lbl" : "alveolar type 1 fibroblast cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets.", + "xrefs" : [ "PMID:22268140", "PMID:26706109", "PMID:28886382", "PMID:29489752", "PMID:30675802", "PMID:33624948", "PMID:33707239", "PMID:9074756" ] + }, + "comments" : [ "A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_4028006", "lbl" : "alveolar adventitial fibroblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia.", + "xrefs" : [ "PMID:26706109", "PMID:28886382", "PMID:29752282", "PMID:30675802", "PMID:33208946", "PMID:33624948" ] + }, + "comments" : [ "A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_4030029", "lbl" : "blood lymphocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lymphocyte located in blood.", + "xrefs" : [ "https://orcid.org/0000-0001-9990-8331" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4030031", "lbl" : "interstitial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes.", + "xrefs" : [ "PMID:24987007" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4030034", "lbl" : "respiratory ciliated cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium.", + "xrefs" : [ "PMID:18757316", "PMID:21364219" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033005", + "lbl" : "serous secreting cell of bronchus submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland.", + "xrefs" : [ "PMID:5487122", "PMID:9651178" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033008", "lbl" : "vein endothelial cell of respiratory system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A(n) vein endothelial cell that is part of a(n) respiratory system.", + "xrefs" : [ "PMID:34030460" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033017", "lbl" : "bronchiolar smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A smooth muscle cell that is part of a bronchiole.", + "xrefs" : [ "ISBN:9781260462982", "PMID:15347627" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033018", "lbl" : "lung megakaryocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A megakaryocyte that is resident in the lung connective tissue.", + "xrefs" : [ "PMID:33351116" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033020", + "lbl" : "mucus secreting cell of trachea gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucus secreting cell that is part of a submucosal gland of the trachea.", + "xrefs" : [ "PMID:18931053", "PMID:29656943" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033022", + "lbl" : "mucus secreting cell of bronchus submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucus secreting cell of a submucosal gland of the bronchus.", + "xrefs" : [ "PMID:19965983" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033037", + "lbl" : "mucus secreting cell of tracheobronchial tree submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucus secreting cell of a submucosal gland of the tracheobronchial tree.", + "xrefs" : [ "PMID:30864819" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033041", "lbl" : "CCL3-positive alveolar macrophage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An alveolar macrophage that expresses CCL3.", + "xrefs" : [ "PMID:37291214" ] + }, + "comments" : [ "A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033042", "lbl" : "metallothionein-positive alveolar macrophage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An alveolar macrophage that expresses metallothionein.", + "xrefs" : [ "PMID:37291214" ] + }, + "comments" : [ "A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033054", "lbl" : "perivascular cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics.", + "xrefs" : [ "PMID:24928499", "PMID:27889329" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033061", + "lbl" : "endothelial cell of central vein of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell that is part of a central vein of liver.", + "xrefs" : [ "PMID:28287163" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4037001", "lbl" : "NS forest marker set of alveolar adventitial fibroblast (Human Lung).", @@ -2798,13014 +7072,37803 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_4040003", "lbl" : "fetal pre-type II pulmonary alveolar epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity.", + "xrefs" : [ "PMID:1316350" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4040004", "lbl" : "mesenchymal stem cell of orbital adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any mesenchymal stem cell of adipose tissue that is part of an orbital region.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000011", "lbl" : "vacuole inheritance", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.", + "xrefs" : [ "GOC:mcc", "PMID:10873824", "PMID:14616069" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000070", "lbl" : "mitotic sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.", + "xrefs" : [ "GOC:ai", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000139", "lbl" : "Golgi membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding any of the compartments of the Golgi apparatus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000226", "lbl" : "microtubule cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000228", "lbl" : "nuclear chromosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.", + "xrefs" : [ "GOC:dph", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000271", "lbl" : "polysaccharide biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0000272", + "lbl" : "polysaccharide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.", + "xrefs" : [ "PMID:33139480" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000278", "lbl" : "mitotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + }, + "comments" : [ "Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle." ], + "xrefs" : [ { + "val" : "Wikipedia:Mitosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000280", "lbl" : "nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000313", "lbl" : "organellar ribosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ribosome contained within a subcellular membrane-bounded organelle.", + "xrefs" : [ "GOC:mah", "GOC:mcc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000323", "lbl" : "lytic vacuole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000740", "lbl" : "nuclear membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of 2 or more lipid bilayer membranes that surround the nucleus.", + "xrefs" : [ "GOC:elh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000741", "lbl" : "karyogamy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.", + "xrefs" : [ "GOC:elh" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Karyogamy" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000768", "lbl" : "syncytium formation by plasma membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.", + "xrefs" : [ "GOC:mtg_muscle", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000785", "lbl" : "chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.", + "xrefs" : [ "GOC:elh", "PMID:20404130" ] + }, + "comments" : [ "Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1615953555" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000791", "lbl" : "euchromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.", + "xrefs" : [ "PMID:32017156" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao445485807" + }, { + "val" : "Wikipedia:Euchromatin" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000792", "lbl" : "heterochromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A compact and highly condensed form of chromatin that is refractory to transcription.", + "xrefs" : [ "PMID:32017156" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao581845896" + }, { + "val" : "Wikipedia:Heterochromatin" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000819", "lbl" : "sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.", + "xrefs" : [ "GOC:ai", "GOC:elh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000902", "lbl" : "cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process in which the size or shape of a cell is generated and organized.", + "xrefs" : [ "GOC:clt", "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001501", "lbl" : "skeletal system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001503", "lbl" : "ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.", + "xrefs" : [ "GOC:mtg_mpo", "PMID:17572649" ] + }, + "comments" : [ "Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'." ], + "xrefs" : [ { + "val" : "Wikipedia:Ossification" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001508", "lbl" : "action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb", "ISBN:978-0-07-139011-8" ] + }, + "comments" : [ "Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001525", "lbl" : "angiogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.", + "xrefs" : [ "ISBN:0878932453" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Angiogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001539", "lbl" : "cilium or flagellum-dependent cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.", + "xrefs" : [ "GOC:cilia", "GOC:hjd", "GOC:krc" ] + }, + "comments" : [ "Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001555", "lbl" : "oocyte growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.", + "xrefs" : [ "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001556", "lbl" : "oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.", + "xrefs" : [ "GOC:devbiol", "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Oocyte_maturation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001558", "lbl" : "regulation of cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, extent or direction of cell growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001560", "lbl" : "regulation of cell growth by extracellular stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001568", "lbl" : "blood vessel development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.", + "xrefs" : [ "GOC:hjd", "UBERON:0001981" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001569", "lbl" : "branching involved in blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001570", "lbl" : "vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.", + "xrefs" : [ "PMID:8999798" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Vasculogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001578", "lbl" : "microtubule bundle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in a parallel arrangement of microtubules.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001654", "lbl" : "eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.", + "xrefs" : [ "GOC:jid", "GOC:jl" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Eye_development" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0001655", + "lbl" : "urogenital system development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001659", "lbl" : "temperature homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process in which an organism modulates its internal body temperature.", + "xrefs" : [ "GOC:jl" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Thermoregulation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001666", "lbl" : "response to hypoxia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.", + "xrefs" : [ "GOC:hjd" ] + }, + "comments" : [ "Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001667", "lbl" : "ameboidal-type cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell migration that is accomplished by extension and retraction of a pseudopodium.", + "xrefs" : [ "GOC:dph" ] + }, + "comments" : [ "Note that this term refers to a mode of migration rather than to any particular cell type." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001674", "lbl" : "female germ cell nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The nucleus of the female germ cell, a reproductive cell in females.", + "xrefs" : [ "CL:0000021", "GOC:hjd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001677", "lbl" : "formation of translation initiation ternary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).", + "xrefs" : [ "GOC:hjd" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0001678", + "lbl" : "intracellular glucose homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of glucose within a cell.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001696", "lbl" : "gastric acid secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.", + "xrefs" : [ "GOC:hjd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001700", "lbl" : "embryonic development via the syncytial blastoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001701", "lbl" : "in utero embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001704", "lbl" : "formation of primary germ layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the ectoderm, mesoderm and endoderm during gastrulation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001705", "lbl" : "ectoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of ectoderm during gastrulation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001706", "lbl" : "endoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the endoderm during gastrulation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001707", "lbl" : "mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001743", "lbl" : "lens placode formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The initial developmental process that will lead to the formation of an eye.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001745", "lbl" : "compound eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:dph", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001751", "lbl" : "compound eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001754", "lbl" : "eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001755", "lbl" : "neural crest cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb", "ISBN:0878932437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001756", "lbl" : "somitogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.", + "xrefs" : [ "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Somitogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001763", "lbl" : "morphogenesis of a branching structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.", + "xrefs" : [ "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001764", "lbl" : "neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.", + "xrefs" : [ "CL:0000540", "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Neural_development#Neuron_migration" + }, { + "val" : "Wikipedia:Neuron_migration" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001767", "lbl" : "establishment of lymphocyte polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.", + "xrefs" : [ "GOC:mgi_curators", "PMID:11244041", "PMID:12615889" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001768", "lbl" : "establishment of T cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.", + "xrefs" : [ "GOC:mgi_curators", "PMID:11244041", "PMID:12615889" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001773", "lbl" : "myeloid dendritic cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001775", "lbl" : "cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell.", + "xrefs" : [ "GOC:mgi_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001776", "lbl" : "leukocyte homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001777", "lbl" : "T cell homeostatic proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001816", "lbl" : "cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001817", "lbl" : "regulation of cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of production of a cytokine.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001818", "lbl" : "negative regulation of cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the rate of production of a cytokine.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001819", "lbl" : "positive regulation of cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of production of a cytokine.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001820", "lbl" : "serotonin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.", + "xrefs" : [ "GOC:ef", "ISBN:0198506732", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001824", "lbl" : "blastocyst development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001825", "lbl" : "blastocyst formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The initial formation of a blastocyst from a solid ball of cells known as a morula.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001826", "lbl" : "inner cell mass cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001829", "lbl" : "trophectodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001831", "lbl" : "trophectodermal cellular morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenesis of trophectoderm cells.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001832", "lbl" : "blastocyst growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001833", "lbl" : "inner cell mass cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The proliferation of cells in the inner cell mass.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001834", "lbl" : "trophectodermal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The proliferation of cells in the trophectoderm.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001837", "lbl" : "epithelial to mesenchymal transition", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.", + "xrefs" : [ "GOC:dph", "PMID:14701881" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001838", "lbl" : "embryonic epithelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenesis of an embryonic epithelium into a tube-shaped structure.", + "xrefs" : [ "GOC:dph", "ISBN:0824072820" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001839", "lbl" : "neural plate morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.", + "xrefs" : [ "GOC:dph", "ISBN:0878932437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001840", "lbl" : "neural plate development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.", + "xrefs" : [ "GOC:dph", "GOC:ef", "ISBN:0878932437", "ISBN:0878932585" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001841", "lbl" : "neural tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.", + "xrefs" : [ "GOC:dph", "ISBN:0878932437" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Neurulation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001842", "lbl" : "neural fold formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.", + "xrefs" : [ "GOC:dph", "ISBN:0878932437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001878", "lbl" : "response to yeast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.", + "xrefs" : [ "PMID:14707091" ] + }, + "comments" : [ "defined as response to Saccharomycotina (true yeasts). This excludes fission yeast." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001885", "lbl" : "endothelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of an endothelial cell over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001886", "lbl" : "endothelial cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0001889", + "lbl" : "liver development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.", + "xrefs" : [ "GOC:add", "ISBN:068340007X" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001894", "lbl" : "tissue homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.", + "xrefs" : [ "GOC:add", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001935", "lbl" : "endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001936", "lbl" : "regulation of endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001937", "lbl" : "negative regulation of endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001938", "lbl" : "positive regulation of endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of endothelial cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001944", "lbl" : "vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.", + "xrefs" : [ "GOC:dph", "UBERON:0002409" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001955", "lbl" : "blood vessel maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001957", "lbl" : "intramembranous ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.", + "xrefs" : [ "ISBN:0878932437" ] + }, + "comments" : [ "An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division." ], + "xrefs" : [ { + "val" : "Wikipedia:Intramembranous_ossification" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002009", "lbl" : "morphogenesis of an epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:tb", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002011", "lbl" : "morphogenesis of an epithelial sheet", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002027", "lbl" : "regulation of heart rate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency or rate of heart contraction.", + "xrefs" : [ "GOC:dph", "GOC:tb", "PMID:10358008" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002052", "lbl" : "positive regulation of neuroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate of neuroblast proliferation.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002053", "lbl" : "positive regulation of mesenchymal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002062", "lbl" : "chondrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002063", "lbl" : "chondrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002064", "lbl" : "epithelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002065", "lbl" : "columnar/cuboidal epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002066", "lbl" : "columnar/cuboidal epithelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002067", "lbl" : "glandular epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002068", "lbl" : "glandular epithelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002069", "lbl" : "columnar/cuboidal epithelial cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002070", "lbl" : "epithelial cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002071", "lbl" : "glandular epithelial cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002072", "lbl" : "optic cup morphogenesis involved in camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.", + "xrefs" : [ "GOC:dph", "GOC:mtg_sensu", "GOC:sdb_2009", "GOC:tb", "ISBN:0878932437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002085", "lbl" : "inhibition of neuroepithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.", + "xrefs" : [ "GOC:dph", "PMID:16678814" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002087", "lbl" : "regulation of respiratory gaseous exchange by nervous system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.", + "xrefs" : [ "GOC:dph", "GOC:tb", "PMID:12458206" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002088", "lbl" : "lens development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.", + "xrefs" : [ "GOC:dph", "ISBN:0582064333" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002089", "lbl" : "lens morphogenesis in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.", + "xrefs" : [ "GOC:dph", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002158", "lbl" : "osteoclast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.", + "xrefs" : [ "CL:0000092", "GOC:hjd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002213", "lbl" : "defense response to insect", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002232", "lbl" : "leukocyte chemotaxis involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002233", "lbl" : "leukocyte chemotaxis involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of an immune cell in response to an external stimulus a part of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002244", "lbl" : "hematopoietic progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.", + "xrefs" : [ "GOC:add", "GOC:rl", "ISBN:0781735149", "PMID:16551251" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002250", "lbl" : "adaptive immune response", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0002252", - "lbl" : "immune effector process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Adaptive_immune_system" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/GO_0002260", + "id" : "http://purl.obolibrary.org/obo/GO_0002251", + "lbl" : "organ or tissue specific immune response", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.", + "xrefs" : [ "GOC:jal", "GO_REF:0000022" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0002252", + "lbl" : "immune effector process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0002260", "lbl" : "lymphocyte homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "GOC:add", "PMID:15826826", "PMID:16319493", "PMID:16551252", "PMID:16551262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002262", "lbl" : "myeloid cell homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "CL:0000763", "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002263", "lbl" : "cell activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002264", "lbl" : "endothelial cell activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002269", "lbl" : "leukocyte activation involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002274", "lbl" : "myeloid leukocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002275", "lbl" : "myeloid cell activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002277", "lbl" : "myeloid dendritic cell activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002280", "lbl" : "monocyte activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:16551245" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002281", "lbl" : "macrophage activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002284", "lbl" : "myeloid dendritic cell differentiation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002285", "lbl" : "lymphocyte activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002286", "lbl" : "T cell activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002292", "lbl" : "T cell differentiation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002309", "lbl" : "T cell proliferation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a T cell population by cell division as part of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002318", "lbl" : "myeloid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.", + "xrefs" : [ "GOC:add", "PMID:16551264" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002320", "lbl" : "lymphoid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.", + "xrefs" : [ "GOC:add", "PMID:16551251", "PMID:16551264" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002351", "lbl" : "serotonin production involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:16730260" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002366", "lbl" : "leukocyte activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002367", "lbl" : "cytokine production involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002369", "lbl" : "T cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that contributes to cytokine production by a T cell.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002371", "lbl" : "dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that contributes to cytokine production by a dendritic cell.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002372", "lbl" : "myeloid dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that contributes to cytokine production by a myeloid dendritic cell.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002376", "lbl" : "immune system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.", + "xrefs" : [ "GOC:add", "GO_REF:0000022" ] + }, + "comments" : [ "Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501)." ], + "xrefs" : [ { + "val" : "Wikipedia:Immune_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0002384", + "lbl" : "hepatic immune response", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immune response taking place in the liver.", + "xrefs" : [ "GOC:jal", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002396", "lbl" : "MHC protein complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15771591", "PMID:15928678" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002399", "lbl" : "MHC class II protein complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15771591" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002407", "lbl" : "dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a dendritic cell in response to an external stimulus.", + "xrefs" : [ "CL:0000451", "GOC:add", "ISBN:0781735149", "PMID:15814331", "PMID:16056255" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002408", "lbl" : "myeloid dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a myeloid dendritic cell in response to an external stimulus.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15814331", "PMID:16056255" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002440", "lbl" : "production of molecular mediator of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002442", "lbl" : "serotonin secretion involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of serotonin by a cell as part of an inflammatory response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002443", "lbl" : "leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the carrying out of an immune response by a leukocyte.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002444", "lbl" : "myeloid leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the carrying out of an immune response by a myeloid leukocyte.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002449", "lbl" : "lymphocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the carrying out of an immune response by a lymphocyte.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002456", "lbl" : "T cell mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the carrying out of an immune response by a T cell.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002457", "lbl" : "T cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "PMID:11417857", "PMID:15120183" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002460", "lbl" : "adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.", + "xrefs" : [ "GOC:add", "GOC:mtg_sensu", "ISBN:0781735149", "ISBN:1405196831" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002468", "lbl" : "dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15771591" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002469", "lbl" : "myeloid dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15771591" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002471", "lbl" : "monocyte antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "PMID:11200054" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002472", "lbl" : "macrophage antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15771591" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002504", "lbl" : "antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15531770", "PMID:15771591", "PMID:16153240" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002520", "lbl" : "immune system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.", + "xrefs" : [ "GOC:add", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002521", "lbl" : "leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.", + "xrefs" : [ "CL:0000738", "GOC:add", "PMID:16551264" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002522", "lbl" : "leukocyte migration involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:14680625", "PMID:14708592", "PMID:7507411", "PMID:8600538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002523", "lbl" : "leukocyte migration involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:14680625", "PMID:14708592", "PMID:7507411", "PMID:8600538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002532", "lbl" : "production of molecular mediator involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "GOC:dph", "GOC:tb", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002534", "lbl" : "cytokine production involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002548", "lbl" : "monocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a monocyte in response to an external stimulus.", + "xrefs" : [ "GOC:add", "PMID:11696603", "PMID:15173832" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002572", "lbl" : "pro-T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002573", "lbl" : "myeloid leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.", + "xrefs" : [ "GOC:add", "PMID:16551251" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002577", "lbl" : "regulation of antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002578", "lbl" : "negative regulation of antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002579", "lbl" : "positive regulation of antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002580", "lbl" : "regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002581", "lbl" : "negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002582", "lbl" : "positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002604", "lbl" : "regulation of dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002605", "lbl" : "negative regulation of dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002606", "lbl" : "positive regulation of dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002607", "lbl" : "regulation of myeloid dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002608", "lbl" : "negative regulation of myeloid dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002609", "lbl" : "positive regulation of myeloid dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002613", "lbl" : "regulation of monocyte antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002614", "lbl" : "negative regulation of monocyte antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002615", "lbl" : "positive regulation of monocyte antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002616", "lbl" : "regulation of macrophage antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002617", "lbl" : "negative regulation of macrophage antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002618", "lbl" : "positive regulation of macrophage antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002625", "lbl" : "regulation of T cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002626", "lbl" : "negative regulation of T cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002627", "lbl" : "positive regulation of T cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002682", "lbl" : "regulation of immune system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of an immune system process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002683", "lbl" : "negative regulation of immune system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002684", "lbl" : "positive regulation of immune system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of an immune system process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002685", "lbl" : "regulation of leukocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of leukocyte migration.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002686", "lbl" : "negative regulation of leukocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002687", "lbl" : "positive regulation of leukocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of leukocyte migration.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002688", "lbl" : "regulation of leukocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002689", "lbl" : "negative regulation of leukocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002690", "lbl" : "positive regulation of leukocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002694", "lbl" : "regulation of leukocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of leukocyte activation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002695", "lbl" : "negative regulation of leukocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002696", "lbl" : "positive regulation of leukocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of leukocyte activation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002697", "lbl" : "regulation of immune effector process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of an immune effector process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002698", "lbl" : "negative regulation of immune effector process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002699", "lbl" : "positive regulation of immune effector process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of an immune effector process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002700", "lbl" : "regulation of production of molecular mediator of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002701", "lbl" : "negative regulation of production of molecular mediator of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002702", "lbl" : "positive regulation of production of molecular mediator of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002703", "lbl" : "regulation of leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002704", "lbl" : "negative regulation of leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002705", "lbl" : "positive regulation of leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002706", "lbl" : "regulation of lymphocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002707", "lbl" : "negative regulation of lymphocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002708", "lbl" : "positive regulation of lymphocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002709", "lbl" : "regulation of T cell mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of T cell mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002710", "lbl" : "negative regulation of T cell mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002711", "lbl" : "positive regulation of T cell mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002718", "lbl" : "regulation of cytokine production involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002719", "lbl" : "negative regulation of cytokine production involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002720", "lbl" : "positive regulation of cytokine production involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002724", "lbl" : "regulation of T cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of T cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002725", "lbl" : "negative regulation of T cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002726", "lbl" : "positive regulation of T cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002730", "lbl" : "regulation of dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002731", "lbl" : "negative regulation of dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002732", "lbl" : "positive regulation of dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002733", "lbl" : "regulation of myeloid dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002734", "lbl" : "negative regulation of myeloid dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002735", "lbl" : "positive regulation of myeloid dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002761", "lbl" : "regulation of myeloid leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002762", "lbl" : "negative regulation of myeloid leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002763", "lbl" : "positive regulation of myeloid leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002790", "lbl" : "peptide secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of a peptide from a cell or a tissue.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002791", "lbl" : "regulation of peptide secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of peptide secretion.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002792", "lbl" : "negative regulation of peptide secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002793", "lbl" : "positive regulation of peptide secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of peptide secretion.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002819", "lbl" : "regulation of adaptive immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of an adaptive immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002820", "lbl" : "negative regulation of adaptive immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002821", "lbl" : "positive regulation of adaptive immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002822", "lbl" : "regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.", + "xrefs" : [ "GOC:add", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002823", "lbl" : "negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.", + "xrefs" : [ "GOC:add", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002824", "lbl" : "positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.", + "xrefs" : [ "GOC:add", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002831", "lbl" : "regulation of response to biotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.", + "xrefs" : [ "GOC:add" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002832", "lbl" : "negative regulation of response to biotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.", + "xrefs" : [ "GOC:add" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002833", "lbl" : "positive regulation of response to biotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.", + "xrefs" : [ "GOC:add" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002886", "lbl" : "regulation of myeloid leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002887", "lbl" : "negative regulation of myeloid leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002888", "lbl" : "positive regulation of myeloid leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002932", "lbl" : "tendon sheath development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move.", + "xrefs" : [ "PMID:20696843" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003002", "lbl" : "regionalization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003006", "lbl" : "developmental process involved in reproduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003007", "lbl" : "heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003008", "lbl" : "system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.", + "xrefs" : [ "GOC:mtg_cardio" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003009", "lbl" : "skeletal muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.", + "xrefs" : [ "GOC:mtg_cardio", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003012", "lbl" : "muscle system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.", + "xrefs" : [ "GOC:mtg_cardio" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003013", "lbl" : "circulatory system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.", + "xrefs" : [ "GOC:mtg_cardio" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Circulatory_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003014", + "lbl" : "renal system process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).", + "xrefs" : [ "GOC:cjm", "GOC:mtg_cardio", "GOC:mtg_kidney_jan10" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003015", "lbl" : "heart process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.", + "xrefs" : [ "GOC:mtg_cardio" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003016", "lbl" : "respiratory system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.", + "xrefs" : [ "GOC:dph", "GOC:mtg_cardio", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003032", "lbl" : "detection of oxygen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal.", + "xrefs" : [ "GOC:mtg_cardio" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003131", "lbl" : "mesodermal-endodermal cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from mesodermal cells to endodermal cells.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003133", "lbl" : "endodermal-mesodermal cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from endodermal cells to mesodermal cells.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003142", "lbl" : "cardiogenic plate morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003143", "lbl" : "embryonic heart tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003144", "lbl" : "embryonic heart tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003145", "lbl" : "embryonic heart tube formation via epithelial folding", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003147", "lbl" : "neural crest cell migration involved in heart formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003148", "lbl" : "outflow tract septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003149", "lbl" : "membranous septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003150", "lbl" : "muscular septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003151", "lbl" : "outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.", + "xrefs" : [ "GOC:mtg_heart", "UBERON:0004145" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003152", "lbl" : "morphogenesis of an epithelial fold involved in embryonic heart tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003156", "lbl" : "regulation of animal organ formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003157", "lbl" : "endocardium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003158", "lbl" : "endothelium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003159", "lbl" : "morphogenesis of an endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003160", "lbl" : "endocardium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003161", "lbl" : "cardiac conduction system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003162", "lbl" : "atrioventricular node development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003163", "lbl" : "sinoatrial node development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003164", "lbl" : "His-Purkinje system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003165", "lbl" : "Purkinje myocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.", + "xrefs" : [ "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003168", "lbl" : "Purkinje myocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.", + "xrefs" : [ "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003169", "lbl" : "coronary vein morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of veins of the heart are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003197", "lbl" : "endocardial cushion development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003203", "lbl" : "endocardial cushion morphogenesis", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0003204", - "lbl" : "cardiac skeleton development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003204", + "lbl" : "cardiac skeleton development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003205", "lbl" : "cardiac chamber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003206", "lbl" : "cardiac chamber morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003207", "lbl" : "cardiac chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003208", "lbl" : "cardiac ventricle morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003209", "lbl" : "cardiac atrium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003210", "lbl" : "cardiac atrium formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003211", "lbl" : "cardiac ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003212", "lbl" : "cardiac left atrium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the left cardiac atrium is generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003213", "lbl" : "cardiac right atrium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the right cardiac atrium is generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003214", "lbl" : "cardiac left ventricle morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the left cardiac ventricle is generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003215", "lbl" : "cardiac right ventricle morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the right cardiac ventricle is generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003216", "lbl" : "cardiac left atrium formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003217", "lbl" : "cardiac right atrium formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003218", "lbl" : "cardiac left ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003219", "lbl" : "cardiac right ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003220", "lbl" : "left ventricular cardiac muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003221", "lbl" : "right ventricular cardiac muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003222", + "lbl" : "ventricular trabecula myocardium morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003225", + "lbl" : "left ventricular trabecular myocardium morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003227", + "lbl" : "right ventricular trabecular myocardium morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the right ventricular myocardium are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003228", "lbl" : "atrial cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003229", "lbl" : "ventricular cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003230", "lbl" : "cardiac atrium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003231", "lbl" : "cardiac ventricle development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003235", "lbl" : "sinus venosus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003236", "lbl" : "sinus venosus morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003237", "lbl" : "sinus venosus formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003241", "lbl" : "growth involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Developmental growth that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003245", "lbl" : "cardiac muscle tissue growth involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003248", "lbl" : "heart capillary growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003253", "lbl" : "cardiac neural crest cell migration involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003260", "lbl" : "cardioblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003272", "lbl" : "endocardial cushion formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.", + "xrefs" : [ "GOC:mtg_heart", "PMID:15797462" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003273", "lbl" : "cell migration involved in endocardial cushion formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003275", "lbl" : "apoptotic process involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003277", "lbl" : "apoptotic process involved in endocardial cushion morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003278", "lbl" : "apoptotic process involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003279", "lbl" : "cardiac septum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a cardiac septum over time, from its initial formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003281", "lbl" : "ventricular septum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the ventricular septum over time from its formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003283", "lbl" : "atrial septum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the atrial septum over time, from its initial formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003292", "lbl" : "cardiac septum cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an endocardial cushion cell becomes a cell of a cardiac septum.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003298", "lbl" : "physiological muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003300", "lbl" : "cardiac muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003301", "lbl" : "physiological cardiac muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003309", + "lbl" : "type B pancreatic cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.", + "xrefs" : [ "CL:0000169", "GOC:dph", "PMID:11076772" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003310", + "lbl" : "pancreatic A cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.", + "xrefs" : [ "GOC:dph", "PMID:11076772" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003311", + "lbl" : "pancreatic D cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.", + "xrefs" : [ "GOC:dph", "PMID:11076772" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003312", + "lbl" : "pancreatic PP cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.", + "xrefs" : [ "GOC:dph", "PMID:11076772" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003313", "lbl" : "heart rudiment development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003314", "lbl" : "heart rudiment morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the heart rudiment are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003315", "lbl" : "heart rudiment formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of the heart rudiment.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003322", + "lbl" : "pancreatic A cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003323", + "lbl" : "type B pancreatic cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.", + "xrefs" : [ "CL:0000169", "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003324", + "lbl" : "pancreatic D cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003325", + "lbl" : "pancreatic PP cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003341", "lbl" : "cilium movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed, self-propelled movement of a cilium.", + "xrefs" : [ "GOC:dph", "GOC:jl" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003342", "lbl" : "proepicardium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.", + "xrefs" : [ "GOC:dph", "PMID:18722343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003343", "lbl" : "septum transversum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme.", + "xrefs" : [ "GOC:dph", "PMID:18722343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003344", "lbl" : "pericardium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the pericardium is generated and organized.", + "xrefs" : [ "GOC:dph", "PMID:18722343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003348", "lbl" : "cardiac endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.", + "xrefs" : [ "GOC:dph", "PMID:18722343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003352", "lbl" : "regulation of cilium movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.", + "xrefs" : [ "GOC:dph" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003353", "lbl" : "positive regulation of cilium movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.", + "xrefs" : [ "GOC:dph" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003354", "lbl" : "negative regulation of cilium movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.", + "xrefs" : [ "GOC:dph" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003360", "lbl" : "brainstem development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003365", "lbl" : "establishment of cell polarity involved in ameboidal cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003371", "lbl" : "establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003379", "lbl" : "establishment of cell polarity involved in gastrulation cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003380", "lbl" : "establishment or maintenance of cytoskeleton polarity involved in gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003381", "lbl" : "epithelial cell morphogenesis involved in gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003382", "lbl" : "epithelial cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003403", "lbl" : "optic vesicle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003404", "lbl" : "optic vesicle morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003407", "lbl" : "neural retina development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003411", "lbl" : "cell motility involved in camera-type eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003413", "lbl" : "chondrocyte differentiation involved in endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003414", "lbl" : "chondrocyte morphogenesis involved in endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003416", "lbl" : "endochondral bone growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003433", "lbl" : "chondrocyte development involved in endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003674", + "lbl" : "molecular_function", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.", + "xrefs" : [ "GOC:pdt" ] + }, + "comments" : [ "Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003824", + "lbl" : "catalytic activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.", + "xrefs" : [ "GOC:vw", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Enzyme" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0004518", + "lbl" : "nuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of the hydrolysis of ester linkages within nucleic acids.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "comments" : [ "Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0004536", + "lbl" : "DNA nuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.", + "xrefs" : [ "GOC:mah", "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-211247" + }, { + "val" : "Reactome:R-HSA-5685994" + }, { + "val" : "Reactome:R-HSA-6785986" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005215", + "lbl" : "transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.", + "xrefs" : [ "GOC:ai", "GOC:dgf" ] + }, + "comments" : [ "Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005275", + "lbl" : "amine transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.", + "xrefs" : [ "GOC:mtg_transport", "ISBN:0198506732", "ISBN:0815340729" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005319", + "lbl" : "lipid transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the directed movement of lipids into, out of or within a cell, or between cells.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-1369028" + }, { + "val" : "Reactome:R-HSA-1369052" + }, { + "val" : "Reactome:R-HSA-174786" + }, { + "val" : "Reactome:R-HSA-5682285" + }, { + "val" : "Reactome:R-HSA-5682311" + }, { + "val" : "Reactome:R-HSA-5683672" + }, { + "val" : "Reactome:R-HSA-5683714" + }, { + "val" : "Reactome:R-HSA-5688397" + }, { + "val" : "Reactome:R-HSA-6801250" + }, { + "val" : "Reactome:R-HSA-8848053" + }, { + "val" : "Reactome:R-HSA-8866329" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005342", + "lbl" : "organic acid transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005355", + "lbl" : "glucose transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.", + "xrefs" : [ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-499981" + }, { + "val" : "Reactome:R-HSA-5653873" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005575", "lbl" : "cellular_component", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).", + "xrefs" : [ "GOC:pdt" ] + }, + "comments" : [ "Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1337158144" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005576", "lbl" : "extracellular region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'." ], + "xrefs" : [ { + "val" : "Wikipedia:Extracellular" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005577", "lbl" : "fibrinogen complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.", + "xrefs" : [ "ISBN:0198547684" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005581", "lbl" : "collagen trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.", + "xrefs" : [ "GOC:dos", "GOC:mah", "ISBN:0721639976", "PMID:19693541", "PMID:21421911" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Collagen" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005583", "lbl" : "fibrillar collagen trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any triple helical collagen trimer that forms fibrils.", + "xrefs" : [ "GOC:mah", "ISBN:0721639976", "PMID:21421911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005585", "lbl" : "collagen type II trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils.", + "xrefs" : [ "ISBN:0721639976" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Collagen_type_II" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005587", "lbl" : "collagen type IV trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.", + "xrefs" : [ "ISBN:0721639976", "PMID:19693541", "PMID:21421911" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Collagen_type_IV" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005604", "lbl" : "basement membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.", + "xrefs" : [ "ISBN:0198547684", "PMID:22505934" ] + }, + "comments" : [ "Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer." ], + "xrefs" : [ { + "val" : "Wikipedia:Basement_membrane" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005615", "lbl" : "extracellular space", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "comments" : [ "Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1425028079" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005622", "lbl" : "intracellular anatomical structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Intracellular" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005634", "lbl" : "nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1702920020" + }, { + "val" : "Wikipedia:Cell_nucleus" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005635", "lbl" : "nuclear envelope", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Nuclear_envelope" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005640", "lbl" : "nuclear outer membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1617136075" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005694", "lbl" : "chromosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "comments" : [ "Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore." ], + "xrefs" : [ { + "val" : "Wikipedia:Chromosome" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005730", "lbl" : "nucleolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1820400233" + }, { + "val" : "Wikipedia:Nucleolus" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005737", "lbl" : "cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cytoplasm" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005764", "lbl" : "lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao585356902" + }, { + "val" : "Wikipedia:Lysosome" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005765", "lbl" : "lysosomal membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005766", "lbl" : "primary lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lysosome before it has fused with a vesicle or vacuole.", + "xrefs" : [ "GOC:jl", "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1140587416" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005773", "lbl" : "vacuole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.", + "xrefs" : [ "GOC:mtg_sensu", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Vacuole" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005774", "lbl" : "vacuolar membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005775", "lbl" : "vacuolar lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The volume enclosed within the vacuolar membrane.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005794", "lbl" : "Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "comments" : [ "Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao451912436" + }, { + "val" : "Wikipedia:Golgi_apparatus" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005798", "lbl" : "Golgi-associated vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this definition includes vesicles that are transiently associated with the Golgi." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao819927218" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005840", "lbl" : "ribosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1429207766" + }, { + "val" : "Wikipedia:Ribosome" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005856", "lbl" : "cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.", + "xrefs" : [ "GOC:mah", "PMID:16959967", "PMID:27419875" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cytoskeleton" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005874", "lbl" : "microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.", + "xrefs" : [ "ISBN:0879693568" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1846835077" + }, { + "val" : "Wikipedia:Microtubule" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005879", "lbl" : "axonemal microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.", + "xrefs" : [ "GOC:cilia", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005880", "lbl" : "nuclear microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microtubule in the nucleus of a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005881", "lbl" : "cytoplasmic microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microtubule in the cytoplasm of a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005884", "lbl" : "actin filament", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732", "PMID:10666339" ] + }, + "xrefs" : [ { + "val" : "FMA:63850" + }, { + "val" : "NIF_Subcellular:sao1588493326" + }, { + "val" : "Wikipedia:Actin" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005886", "lbl" : "plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.", + "xrefs" : [ "ISBN:0716731363" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1663586795" + }, { + "val" : "Wikipedia:Cell_membrane" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005902", "lbl" : "microvillus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.", + "xrefs" : [ "ISBN:0815316194" ] + }, + "comments" : [ "Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao671419673" + }, { + "val" : "Wikipedia:Microvillus" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005911", "lbl" : "cell-cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "GOC:dgh", "GOC:hb", "GOC:mah", "PMID:21422226", "PMID:28096264" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1922892319" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005929", "lbl" : "cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.", + "xrefs" : [ "GOC:cilia", "GOC:curators", "GOC:kmv", "GOC:vw", "ISBN:0198547684", "PMID:16824949", "PMID:17009929", "PMID:20144998" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms." ], + "xrefs" : [ { + "val" : "FMA:67181" + }, { + "val" : "NIF_Subcellular:sao787716553" + }, { + "val" : "Wikipedia:Cilium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005930", "lbl" : "axoneme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.", + "xrefs" : [ "GOC:bf", "GOC:cilia", "ISBN:0198547684" ] + }, + "comments" : [ "Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane." ], + "xrefs" : [ { + "val" : "Wikipedia:Axoneme" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005938", "lbl" : "cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_cortex" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005975", "lbl" : "carbohydrate metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Carbohydrate_metabolism" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005976", "lbl" : "polysaccharide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.", + "xrefs" : [ "ISBN:0198547684" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005977", + "lbl" : "glycogen metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005978", + "lbl" : "glycogen biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "MetaCyc:GLYCOGENSYNTH-PWY" + }, { + "val" : "MetaCyc:PWY-5067" + }, { + "val" : "MetaCyc:PWY-7900" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005979", + "lbl" : "regulation of glycogen biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005980", + "lbl" : "glycogen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "MetaCyc:GLYCOCAT-PWY" + }, { + "val" : "MetaCyc:PWY-5941" + }, { + "val" : "MetaCyc:PWY-7662" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005981", + "lbl" : "regulation of glycogen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006006", + "lbl" : "glucose metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006007", + "lbl" : "glucose catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006024", "lbl" : "glycosaminoglycan biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.", + "xrefs" : [ "ISBN:0192800981" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006027", + "lbl" : "glycosaminoglycan catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars.", + "xrefs" : [ "ISBN:0192800981" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006082", + "lbl" : "organic acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006091", + "lbl" : "generation of precursor metabolites and energy", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006094", + "lbl" : "gluconeogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.", + "xrefs" : [ "MetaCyc:GLUCONEO-PWY" ] + }, + "xrefs" : [ { + "val" : "MetaCyc:GLUCONEO-PWY" + }, { + "val" : "Wikipedia:Gluconeogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006109", "lbl" : "regulation of carbohydrate metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006111", + "lbl" : "regulation of gluconeogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006112", + "lbl" : "energy reserve metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006139", "lbl" : "nucleobase-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006259", "lbl" : "DNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006308", + "lbl" : "DNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006309", + "lbl" : "apoptotic DNA fragmentation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:mtg_apoptosis", "GOC:tb", "ISBN:0721639976", "PMID:15723341", "PMID:23379520" ] + }, + "comments" : [ "DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006325", "lbl" : "chromatin organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.", + "xrefs" : [ "PMID:20404130" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006401", + "lbl" : "RNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006403", "lbl" : "RNA localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which RNA is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006412", "lbl" : "translation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Translation_(genetics)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006413", "lbl" : "translational initiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.", + "xrefs" : [ "ISBN:019879276X" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006414", "lbl" : "translational elongation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.", + "xrefs" : [ "GOC:ems" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006415", "lbl" : "translational termination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).", + "xrefs" : [ "GOC:hjd", "ISBN:019879276X" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006417", "lbl" : "regulation of translation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006446", "lbl" : "regulation of translational initiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of translational initiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006448", "lbl" : "regulation of translational elongation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, extent or accuracy of translational elongation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006449", "lbl" : "regulation of translational termination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of translational termination.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006516", + "lbl" : "glycoprotein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006518", "lbl" : "peptide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006576", "lbl" : "biogenic amine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.", + "xrefs" : [ "GOC:jl", "ISBN:0395825172" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006584", "lbl" : "catecholamine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006629", "lbl" : "lipid metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.", + "xrefs" : [ "GOC:ma" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Lipid_metabolism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006694", + "lbl" : "steroid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Steroid_metabolisms#Steroid_biosynthesis" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006699", + "lbl" : "bile acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006706", + "lbl" : "steroid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006810", "lbl" : "transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.", + "xrefs" : [ "GOC:dos", "GOC:dph", "GOC:jl", "GOC:mah" ] + }, + "comments" : [ "Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006811", "lbl" : "monoatomic ion transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006837", "lbl" : "serotonin transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006858", "lbl" : "extracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The transport of substances that occurs outside cells.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006869", "lbl" : "lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006873", + "lbl" : "intracellular monoatomic ion homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006886", "lbl" : "intracellular protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006887", "lbl" : "exocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.", + "xrefs" : [ "GOC:mah", "ISBN:0716731363", "PMID:22323285" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Exocytosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006892", "lbl" : "post-Golgi vesicle-mediated transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.", + "xrefs" : [ "GOC:ai", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006893", "lbl" : "Golgi to plasma membrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.", + "xrefs" : [ "ISBN:0716731363" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006896", "lbl" : "Golgi to vacuole transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances from the Golgi to the vacuole.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006897", "lbl" : "endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732", "ISBN:0716731363", "Wikipedia:Endocytosis" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Endocytosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006900", "lbl" : "vesicle budding from membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The evagination of a membrane, resulting in formation of a vesicle.", + "xrefs" : [ "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006903", "lbl" : "vesicle targeting", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.", + "xrefs" : [ "GOC:mah", "PMID:17335816" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006906", "lbl" : "vesicle fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fusion of the membrane of a transport vesicle with its target membrane.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006909", "lbl" : "phagocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Phagocytosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006915", "lbl" : "apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.", + "xrefs" : [ "GOC:cjm", "GOC:dhl", "GOC:ecd", "GOC:go_curators", "GOC:mtg_apoptosis", "GOC:tb", "ISBN:0198506732", "PMID:18846107", "PMID:21494263" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Apoptosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006921", "lbl" : "cellular component disassembly involved in execution phase of apoptosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006925", "lbl" : "inflammatory cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage.", + "xrefs" : [ "GOC:jl", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006935", "lbl" : "chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Chemotaxis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006936", "lbl" : "muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.", + "xrefs" : [ "GOC:ef", "GOC:mtg_muscle", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Muscle_contraction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006937", "lbl" : "regulation of muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006939", "lbl" : "smooth muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.", + "xrefs" : [ "GOC:ef", "GOC:jl", "GOC:mtg_muscle", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006940", "lbl" : "regulation of smooth muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006941", "lbl" : "striated muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.", + "xrefs" : [ "GOC:jl", "GOC:mtg_muscle", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006942", "lbl" : "regulation of striated muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of striated muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006949", "lbl" : "syncytium formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006950", "lbl" : "response to stress", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006952", "lbl" : "defense response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006954", "lbl" : "inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.", + "xrefs" : [ "GO_REF:0000022", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Inflammation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006955", "lbl" : "immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.", + "xrefs" : [ "GOC:add", "GO_REF:0000022" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006996", "lbl" : "organelle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006997", "lbl" : "nucleus organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006998", "lbl" : "nuclear envelope organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007000", "lbl" : "nucleolus organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007009", "lbl" : "plasma membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007010", "lbl" : "cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007015", "lbl" : "actin filament organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007017", "lbl" : "microtubule-based process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007018", "lbl" : "microtubule-based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.", + "xrefs" : [ "GOC:cjm", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007019", "lbl" : "microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The removal of tubulin heterodimers from one or both ends of a microtubule.", + "xrefs" : [ "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007020", "lbl" : "microtubule nucleation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).", + "xrefs" : [ "GOC:go_curators", "ISBN:0815316194", "PMID:12517712" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Microtubule_nucleation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007026", "lbl" : "negative regulation of microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007027", "lbl" : "negative regulation of axonemal microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme.", + "xrefs" : [ "GOC:dph", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007028", "lbl" : "cytoplasm organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.", + "xrefs" : [ "GOC:curators", "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007030", "lbl" : "Golgi organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007033", "lbl" : "vacuole organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007034", "lbl" : "vacuolar transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances into, out of or within a vacuole.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007039", + "lbl" : "protein catabolic process in the vacuole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases.", + "xrefs" : [ "GOC:mah", "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007040", "lbl" : "lysosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007041", "lbl" : "lysosomal transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances into, out of or within a lysosome.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007043", "lbl" : "cell-cell junction assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a junction between cells.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007049", "lbl" : "cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_cell_cycle" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_cycle" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007059", "lbl" : "chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.", + "xrefs" : [ "GOC:jl", "GOC:mah", "GOC:mtg_cell_cycle", "GOC:vw" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Chromosome_segregation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007076", "lbl" : "mitotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007077", "lbl" : "mitotic nuclear membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis.", + "xrefs" : [ "GOC:bf", "PMID:32848252" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007088", "lbl" : "regulation of mitotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mitosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007097", "lbl" : "nuclear migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of the nucleus to a specific location within a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007113", "lbl" : "endomitotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.", + "xrefs" : [ "GOC:curators", "GOC:dos", "GOC:expert_vm" ] + }, + "comments" : [ "Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins." ], + "xrefs" : [ { + "val" : "Wikipedia:Mitosis#Endomitosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007143", "lbl" : "female meiotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:mah", "GOC:vw" ] + }, + "comments" : [ "Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007154", "lbl" : "cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_signaling" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007155", "lbl" : "cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.", + "xrefs" : [ "GOC:hb", "GOC:pf" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_adhesion" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007159", "lbl" : "leukocyte cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The attachment of a leukocyte to another cell via adhesion molecules.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007162", "lbl" : "negative regulation of cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007163", "lbl" : "establishment or maintenance of cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007165", "lbl" : "signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_signaling_feb11" ] + }, + "comments" : [ "Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not." ], + "xrefs" : [ { + "val" : "Wikipedia:Signal_transduction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007267", "lbl" : "cell-cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.", + "xrefs" : [ "GOC:dos", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007268", "lbl" : "chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.", + "xrefs" : [ "GOC:jl", "MeSH:D009435" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Neurotransmission" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007275", "lbl" : "multicellular organism development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:isa_complete", "GOC:tb" ] + }, + "comments" : [ "Note that this term was 'developmental process'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007276", "lbl" : "gamete generation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.", + "xrefs" : [ "GOC:ems", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007281", "lbl" : "germ cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007292", "lbl" : "female gamete generation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.", + "xrefs" : [ "GOC:dph", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007293", "lbl" : "germarium-derived egg chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:mtg_sensu", "ISBN:0879694238" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007308", "lbl" : "oocyte construction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:mtg_sensu", "GOC:tb", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007338", "lbl" : "single fertilization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The union of male and female gametes to form a zygote.", + "xrefs" : [ "GOC:ems", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007343", "lbl" : "egg activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm.", + "xrefs" : [ "GOC:bf", "PMID:9630751" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Egg_activation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007346", "lbl" : "regulation of mitotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of progress through the mitotic cell cycle.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007350", "lbl" : "blastoderm segmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.", + "xrefs" : [ "ISBN:0879694238", "http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007369", "lbl" : "gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.", + "xrefs" : [ "GOC:curators", "ISBN:9780878933846" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Gastrulation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007389", "lbl" : "pattern specification process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.", + "xrefs" : [ "GOC:go_curators", "GOC:isa_complete", "ISBN:0521436125" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007398", "lbl" : "ectoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007399", "lbl" : "nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007405", "lbl" : "neuroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.", + "xrefs" : [ "GOC:ai", "GOC:mtg_sensu", "GOC:sart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007406", "lbl" : "negative regulation of neuroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007407", "lbl" : "neuroblast activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007416", "lbl" : "synapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Synaptogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007417", "lbl" : "central nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.", + "xrefs" : [ "GOC:bf", "GOC:jid", "ISBN:0582227089" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Neural_development" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007420", "lbl" : "brain development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb", "UBERON:0000955" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007422", "lbl" : "peripheral nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.", + "xrefs" : [ "GOC:go_curators", "UBERON:0000010" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007423", "lbl" : "sensory organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007439", "lbl" : "ectodermal digestive tract development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007440", "lbl" : "foregut morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the foregut are generated and organized.", + "xrefs" : [ "GOC:jid" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007442", + "lbl" : "hindgut morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the hindgut are generated and organized.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007492", "lbl" : "endoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007494", + "lbl" : "midgut development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.", + "xrefs" : [ "GOC:jid", "UBERON:0001045" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007498", "lbl" : "mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007506", "lbl" : "gonadal mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007507", "lbl" : "heart development", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7227" + "definition" : { + "val" : "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.", + "xrefs" : [ "GOC:jid", "UBERON:0000948" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Heart_development" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007517", "lbl" : "muscle organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.", + "xrefs" : [ "GOC:jid", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007519", "lbl" : "skeletal muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007528", "lbl" : "neuromuscular junction development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.", + "xrefs" : [ "GOC:mtg_OBO2OWL_2013" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007548", "lbl" : "sex differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The establishment of the sex of an organism by physical differentiation.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Sexual_differentiation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007565", "lbl" : "female pregnancy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.", + "xrefs" : [ "ISBN:0192800825" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Gestation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007566", "lbl" : "embryo implantation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Attachment of the blastocyst to the uterine lining.", + "xrefs" : [ "GOC:isa_complete", "PMID:10882512" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007585", "lbl" : "respiratory gaseous exchange by respiratory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007586", "lbl" : "digestion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:isa_complete", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Digestion" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007588", + "lbl" : "excretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.", + "xrefs" : [ "ISBN:0192801023" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Excretion" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007589", + "lbl" : "body fluid secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of a fluid by a cell or tissue in an animal.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007600", "lbl" : "sensory perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.", + "xrefs" : [ "GOC:ai", "GOC:dph" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Perception" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007601", "lbl" : "visual perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Visual_perception" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007605", "lbl" : "sensory perception of sound", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Hearing_(sense)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007606", "lbl" : "sensory perception of chemical stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007610", + "lbl" : "behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.", + "xrefs" : [ "GOC:ems", "GOC:jl", "ISBN:0395448956", "PMID:20160973" ] + }, + "comments" : [ "1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis)." ], + "xrefs" : [ { + "val" : "Wikipedia:Behavior" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007626", + "lbl" : "locomotory behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008015", "lbl" : "blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.", + "xrefs" : [ "GOC:mtg_heart", "ISBN:0192800825" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008016", "lbl" : "regulation of heart contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008078", "lbl" : "mesodermal cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of mesodermal cells from one site to another.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:mah", "GOC:sat", "GOC:tb", "PMID:25119047" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008088", "lbl" : "axo-dendritic transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of organelles or molecules along microtubules in neuron projections.", + "xrefs" : [ "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Axoplasmic_transport" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008104", "lbl" : "protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008150", "lbl" : "biological_process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.", + "xrefs" : [ "GOC:pdt" ] + }, + "comments" : [ "Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this." ], + "xrefs" : [ { + "val" : "Wikipedia:Biological_process" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008152", "lbl" : "metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198547684" ] + }, + "comments" : [ "Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions." ], + "xrefs" : [ { + "val" : "Wikipedia:Metabolism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0008202", + "lbl" : "steroid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Steroid_metabolism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0008206", + "lbl" : "bile acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008219", "lbl" : "cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis", "PMID:25236395" ] + }, + "comments" : [ "This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008283", "lbl" : "cell population proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population.", + "xrefs" : [ "GOC:mah", "GOC:mb" ] + }, + "comments" : [ "This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008284", "lbl" : "positive regulation of cell population proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of cell proliferation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008285", "lbl" : "negative regulation of cell population proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of cell proliferation.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0008320", + "lbl" : "protein transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a protein from one side of a membrane to the other.", + "xrefs" : [ "GOC:jl" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-1268022" + }, { + "val" : "Reactome:R-HSA-1299475" + }, { + "val" : "Reactome:R-HSA-184269" + }, { + "val" : "Reactome:R-HSA-3149434" + }, { + "val" : "Reactome:R-HSA-5205661" + }, { + "val" : "Reactome:R-HSA-5210943" + }, { + "val" : "Reactome:R-HSA-5210947" + }, { + "val" : "Reactome:R-HSA-5228406" + }, { + "val" : "Reactome:R-HSA-5229111" + }, { + "val" : "Reactome:R-HSA-5244404" + }, { + "val" : "Reactome:R-HSA-5244428" + }, { + "val" : "Reactome:R-HSA-5244506" + }, { + "val" : "Reactome:R-HSA-5246514" + }, { + "val" : "Reactome:R-HSA-5250616" + }, { + "val" : "Reactome:R-HSA-5250884" + }, { + "val" : "Reactome:R-HSA-5250972" + }, { + "val" : "Reactome:R-HSA-5336420" + }, { + "val" : "Reactome:R-HSA-9636375" + }, { + "val" : "Reactome:R-HSA-9698930" + }, { + "val" : "Reactome:R-HSA-9698933" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008347", "lbl" : "glial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.", + "xrefs" : [ "GOC:jl", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008354", "lbl" : "germ cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.", + "xrefs" : [ "GOC:bf", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008356", "lbl" : "asymmetric cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.", + "xrefs" : [ "PMID:11672519" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Asymmetric_cell_division" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008406", "lbl" : "gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.", + "xrefs" : [ "GOC:ems", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008544", "lbl" : "epidermis development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.", + "xrefs" : [ "GOC:go_curators", "UBERON:0001003" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008585", "lbl" : "female gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008594", "lbl" : "photoreceptor cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:jid", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008610", "lbl" : "lipid biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008643", "lbl" : "carbohydrate transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0008645", + "lbl" : "hexose transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule.", + "xrefs" : [ "GOC:vw" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009056", + "lbl" : "catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Catabolism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009057", + "lbl" : "macromolecule catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009058", "lbl" : "biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.", + "xrefs" : [ "GOC:curators", "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Anabolism" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009059", "lbl" : "macromolecule biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009100", "lbl" : "glycoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009101", "lbl" : "glycoprotein biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009250", + "lbl" : "glucan biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009251", + "lbl" : "glucan catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009306", "lbl" : "protein secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of proteins from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009308", "lbl" : "amine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009309", "lbl" : "amine biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009310", + "lbl" : "amine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009314", "lbl" : "response to radiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.", + "xrefs" : [ "GOC:jl", "Wikipedia:Electromagnetic_radiation" ] + }, + "comments" : [ "Note that 'radiation' refers to electromagnetic radiation of any wavelength." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009416", "lbl" : "response to light stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.", + "xrefs" : [ "GOC:go_curators", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009566", "lbl" : "fertilization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).", + "xrefs" : [ "GOC:tb", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Fertilisation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009581", "lbl" : "detection of external stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which an external stimulus is received by a cell and converted into a molecular signal.", + "xrefs" : [ "GOC:hb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009582", "lbl" : "detection of abiotic stimulus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0009583", - "lbl" : "detection of light stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.", + "xrefs" : [ "GOC:hb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009583", + "lbl" : "detection of light stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009584", "lbl" : "detection of visible light", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009593", "lbl" : "detection of chemical stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009605", "lbl" : "response to external stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.", + "xrefs" : [ "GOC:hb" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009607", "lbl" : "response to biotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.", + "xrefs" : [ "GOC:hb" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009617", "lbl" : "response to bacterium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.", + "xrefs" : [ "GOC:hb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009620", "lbl" : "response to fungus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.", + "xrefs" : [ "GOC:hb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009628", "lbl" : "response to abiotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.", + "xrefs" : [ "GOC:hb" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009636", + "lbl" : "response to toxic substance", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.", + "xrefs" : [ "GOC:lr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009653", "lbl" : "anatomical structure morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.", + "xrefs" : [ "GOC:go_curators", "ISBN:0521436125" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Morphogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009712", "lbl" : "catechol-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent.", + "xrefs" : [ "GOC:sm", "ISBN:0198547684" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009713", "lbl" : "catechol-containing compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009719", "lbl" : "response to endogenous stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.", + "xrefs" : [ "GOC:sm" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009725", "lbl" : "response to hormone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009743", "lbl" : "response to carbohydrate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009746", + "lbl" : "response to hexose", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009749", + "lbl" : "response to glucose", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009786", "lbl" : "regulation of asymmetric cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of asymmetric cell division.", + "xrefs" : [ "GOC:lr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009790", "lbl" : "embryo development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.", + "xrefs" : [ "GOC:go_curators", "GOC:isa_complete", "GOC:mtg_sensu" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Embryogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009791", "lbl" : "post-embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009792", "lbl" : "embryo development ending in birth or egg hatching", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.", + "xrefs" : [ "GOC:go_curators", "GOC:isa_complete", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009880", "lbl" : "embryonic pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that results in the patterns of cell differentiation that will arise in an embryo.", + "xrefs" : [ "GOC:go_curators", "ISBN:0521436125" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009887", "lbl" : "animal organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:dgh", "GOC:go_curators", "ISBN:0471245208", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009888", "lbl" : "tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.", + "xrefs" : [ "ISBN:0471245208" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Histogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009889", "lbl" : "regulation of biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009890", "lbl" : "negative regulation of biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009891", "lbl" : "positive regulation of biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009892", "lbl" : "negative regulation of metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009893", "lbl" : "positive regulation of metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009894", + "lbl" : "regulation of catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009895", + "lbl" : "negative regulation of catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009896", + "lbl" : "positive regulation of catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009913", "lbl" : "epidermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:mtg_sensu", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009914", "lbl" : "hormone transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009952", "lbl" : "anterior/posterior pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:isa_complete", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009966", "lbl" : "regulation of signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of signal transduction.", + "xrefs" : [ "GOC:sm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009967", "lbl" : "positive regulation of signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of signal transduction.", + "xrefs" : [ "GOC:sm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009968", "lbl" : "negative regulation of signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.", + "xrefs" : [ "GOC:sm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009987", "lbl" : "cellular process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.", + "xrefs" : [ "GOC:go_curators", "GOC:isa_complete" ] + }, + "comments" : [ "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009994", "lbl" : "oocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010001", "lbl" : "glial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010002", "lbl" : "cardioblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010032", "lbl" : "meiotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Compaction of chromatin structure prior to meiosis in eukaryotic cells.", + "xrefs" : [ "PMID:10072401" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010070", "lbl" : "zygote asymmetric cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010160", "lbl" : "formation of animal organ boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "PMID:9611175" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010171", "lbl" : "body morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the soma are generated and organized.", + "xrefs" : [ "GOC:ems", "ISBN:0140512888" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010243", "lbl" : "response to organonitrogen compound", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.", + "xrefs" : [ "PMID:9869419" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010256", "lbl" : "endomembrane system organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.", + "xrefs" : [ "GOC:mah", "GOC:sm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010324", "lbl" : "membrane invagination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The infolding of a membrane.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010453", "lbl" : "regulation of cell fate commitment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010454", "lbl" : "negative regulation of cell fate commitment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010455", "lbl" : "positive regulation of cell fate commitment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010463", "lbl" : "mesenchymal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010464", "lbl" : "regulation of mesenchymal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010467", "lbl" : "gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes.", + "xrefs" : [ "GOC:txnOH-2018", "PMID:25934543", "PMID:31580950" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Gene_expression" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010468", "lbl" : "regulation of gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).", + "xrefs" : [ "GOC:txnOH-2018" ] + }, + "comments" : [ "This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation." ], + "xrefs" : [ { + "val" : "Wikipedia:Regulation_of_gene_expression" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010470", "lbl" : "regulation of gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010481", "lbl" : "epidermal cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells.", + "xrefs" : [ "PMID:17450124" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010482", "lbl" : "regulation of epidermal cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis.", + "xrefs" : [ "PMID:17450124" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010496", "lbl" : "intercellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of substances between cells.", + "xrefs" : [ "GOC:dhl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010549", "lbl" : "regulation of membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of membrane disassembly.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010556", "lbl" : "regulation of macromolecule biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010557", "lbl" : "positive regulation of macromolecule biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010558", "lbl" : "negative regulation of macromolecule biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010559", "lbl" : "regulation of glycoprotein biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010560", "lbl" : "positive regulation of glycoprotein biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010561", "lbl" : "negative regulation of glycoprotein biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010564", "lbl" : "regulation of cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010565", + "lbl" : "regulation of cellular ketone metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010566", + "lbl" : "regulation of ketone biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010567", + "lbl" : "regulation of ketone catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010594", "lbl" : "regulation of endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010595", "lbl" : "positive regulation of endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010596", "lbl" : "negative regulation of endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010604", "lbl" : "positive regulation of macromolecule metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010605", "lbl" : "negative regulation of macromolecule metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010608", "lbl" : "post-transcriptional regulation of gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010611", "lbl" : "regulation of cardiac muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010612", "lbl" : "regulation of cardiac muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010613", "lbl" : "positive regulation of cardiac muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010614", "lbl" : "negative regulation of cardiac muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010615", "lbl" : "positive regulation of cardiac muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010616", "lbl" : "negative regulation of cardiac muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010623", "lbl" : "programmed cell death involved in cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The activation of endogenous cellular processes that result in the death of a cell as part of its development.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + }, + "comments" : [ "This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010628", "lbl" : "positive regulation of gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).", + "xrefs" : [ "GOC:txnOH-2018" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010629", "lbl" : "negative regulation of gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).", + "xrefs" : [ "GOC:txnOH-2018" ] + }, + "comments" : [ "This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010631", "lbl" : "epithelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "GOC:BHF", "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010632", "lbl" : "regulation of epithelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010633", "lbl" : "negative regulation of epithelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010634", "lbl" : "positive regulation of epithelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epithelial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010638", "lbl" : "positive regulation of organelle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010639", "lbl" : "negative regulation of organelle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010646", "lbl" : "regulation of cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010647", "lbl" : "positive regulation of cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010648", "lbl" : "negative regulation of cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010656", "lbl" : "negative regulation of muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010657", "lbl" : "muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle.", + "xrefs" : [ "CL:0000187", "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010658", "lbl" : "striated muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations.", + "xrefs" : [ "CL:0000737", "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010659", "lbl" : "cardiac muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.", + "xrefs" : [ "CL:0000746", "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010660", "lbl" : "regulation of muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010661", "lbl" : "positive regulation of muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010662", "lbl" : "regulation of striated muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010663", "lbl" : "positive regulation of striated muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010664", "lbl" : "negative regulation of striated muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:mtg_apoptosis", "GOC:rl", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010665", "lbl" : "regulation of cardiac muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010666", "lbl" : "positive regulation of cardiac muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010667", "lbl" : "negative regulation of cardiac muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:mtg_apoptosis", "GOC:rl", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010668", "lbl" : "ectodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010700", "lbl" : "negative regulation of norepinephrine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010701", "lbl" : "positive regulation of norepinephrine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010710", + "lbl" : "regulation of collagen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010711", + "lbl" : "negative regulation of collagen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010712", "lbl" : "regulation of collagen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010713", "lbl" : "negative regulation of collagen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010714", "lbl" : "positive regulation of collagen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010715", "lbl" : "regulation of extracellular matrix disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010716", "lbl" : "negative regulation of extracellular matrix disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010717", "lbl" : "regulation of epithelial to mesenchymal transition", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010718", "lbl" : "positive regulation of epithelial to mesenchymal transition", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010719", "lbl" : "negative regulation of epithelial to mesenchymal transition", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010720", "lbl" : "positive regulation of cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010721", "lbl" : "negative regulation of cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010758", "lbl" : "regulation of macrophage chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010759", "lbl" : "positive regulation of macrophage chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010760", "lbl" : "negative regulation of macrophage chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010761", "lbl" : "fibroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010762", "lbl" : "regulation of fibroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010763", "lbl" : "positive regulation of fibroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010764", "lbl" : "negative regulation of fibroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010770", "lbl" : "positive regulation of cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010771", "lbl" : "negative regulation of cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010817", "lbl" : "regulation of hormone levels", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010818", "lbl" : "T cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010819", "lbl" : "regulation of T cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010820", "lbl" : "positive regulation of T cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010827", + "lbl" : "regulation of glucose transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010828", + "lbl" : "positive regulation of glucose transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010829", + "lbl" : "negative regulation of glucose transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010830", "lbl" : "regulation of myotube differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010831", "lbl" : "positive regulation of myotube differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010832", "lbl" : "negative regulation of myotube differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010842", "lbl" : "retina layer formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb", "PMID:1270266" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010876", "lbl" : "lipid localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a lipid is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010893", + "lbl" : "positive regulation of steroid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.", + "xrefs" : [ "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010894", + "lbl" : "negative regulation of steroid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.", + "xrefs" : [ "GOC:BHF", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010906", + "lbl" : "regulation of glucose metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.", + "xrefs" : [ "GOC:BHF", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010907", + "lbl" : "positive regulation of glucose metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.", + "xrefs" : [ "GOC:BHF", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010927", "lbl" : "cellular component assembly involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular component assembly that is part of the initial shaping of the component during its developmental progression.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010934", "lbl" : "macrophage cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:rl", "GOC:tb" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010935", "lbl" : "regulation of macrophage cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010936", "lbl" : "negative regulation of macrophage cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010937", "lbl" : "regulation of cytoplasmic microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010938", "lbl" : "cytoplasmic microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010948", "lbl" : "negative regulation of cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010962", + "lbl" : "regulation of glucan biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010968", "lbl" : "regulation of microtubule nucleation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010970", "lbl" : "transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010975", "lbl" : "regulation of neuron projection development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010976", "lbl" : "positive regulation of neuron projection development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010977", "lbl" : "negative regulation of neuron projection development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0012501", "lbl" : "programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.", + "xrefs" : [ "GOC:lr", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children." ], + "xrefs" : [ { + "val" : "Wikipedia:Programmed_cell_death" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0012505", "lbl" : "endomembrane system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.", + "xrefs" : [ "GOC:lh" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Endomembrane_system" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0012506", "lbl" : "vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding any membrane-bounded vesicle in the cell.", + "xrefs" : [ "GOC:mah", "GOC:vesicle" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1153182838" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014009", "lbl" : "glial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.", + "xrefs" : [ "GOC:ef", "ISBN:0878932585" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014013", "lbl" : "regulation of gliogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014014", "lbl" : "negative regulation of gliogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014015", "lbl" : "positive regulation of gliogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014016", "lbl" : "neuroblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts.", + "xrefs" : [ "GOC:ef", "ISBN:0878932585" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014019", "lbl" : "neuroblast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron.", + "xrefs" : [ "GOC:ef", "ISBN:0878932585" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014020", "lbl" : "primary neural tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.", + "xrefs" : [ "GOC:ef", "ISBN:0878932585", "PMID:15327780" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014023", "lbl" : "neural rod formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014025", "lbl" : "neural keel formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014028", "lbl" : "notochord formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014029", "lbl" : "neural crest formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014031", "lbl" : "mesenchymal cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014032", "lbl" : "neural crest cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014033", "lbl" : "neural crest cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014041", "lbl" : "regulation of neuron maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014042", "lbl" : "positive regulation of neuron maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuron maturation.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014043", "lbl" : "negative regulation of neuron maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014061", "lbl" : "regulation of norepinephrine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014062", "lbl" : "regulation of serotonin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of serotonin.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014063", "lbl" : "negative regulation of serotonin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014064", "lbl" : "positive regulation of serotonin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014075", "lbl" : "response to amine", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014706", "lbl" : "striated muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.", + "xrefs" : [ "CL:0000737", "GOC:dph", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014733", "lbl" : "regulation of skeletal muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014734", "lbl" : "skeletal muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014741", "lbl" : "negative regulation of muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014742", "lbl" : "positive regulation of muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014743", "lbl" : "regulation of muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle hypertrophy.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014744", "lbl" : "positive regulation of muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of muscle adaptation.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014745", "lbl" : "negative regulation of muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014805", "lbl" : "smooth muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014807", "lbl" : "regulation of somitogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of somitogenesis.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014812", "lbl" : "muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "CL:0000187", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014819", "lbl" : "regulation of skeletal muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle contraction.", + "xrefs" : [ "GOC:ef", "GOC:mtg_muscle" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0014821", + "lbl" : "phasic smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0014827", + "lbl" : "intestine smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine.", + "xrefs" : [ "GOC:mtg_muscle", "MA:0001539", "MSH:D007422" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0014831", + "lbl" : "gastro-intestinal system smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract).", + "xrefs" : [ "GOC:mtg_muscle", "MA:0001523", "MSH:D041981" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014855", "lbl" : "striated muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.", + "xrefs" : [ "CL:0000737", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014856", "lbl" : "skeletal muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population.", + "xrefs" : [ "CL:0000188", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014857", "lbl" : "regulation of skeletal muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation.", + "xrefs" : [ "CL:0000188", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014858", "lbl" : "positive regulation of skeletal muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation.", + "xrefs" : [ "CL:0000188", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014859", "lbl" : "negative regulation of skeletal muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation.", + "xrefs" : [ "CL:0000188", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014861", "lbl" : "regulation of skeletal muscle contraction via regulation of action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014866", "lbl" : "skeletal myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.", + "xrefs" : [ "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014872", "lbl" : "myoblast division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014874", "lbl" : "response to stimulus involved in regulation of muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation.", + "xrefs" : [ "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014887", "lbl" : "cardiac muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014888", "lbl" : "striated muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014895", "lbl" : "smooth muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014896", "lbl" : "muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy.", + "xrefs" : [ "GOC:mtg_muscle" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Muscle_hypertrophy" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014897", "lbl" : "striated muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014902", "lbl" : "myotube differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014904", "lbl" : "myotube cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014909", "lbl" : "smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "CL:0000192", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014910", "lbl" : "regulation of smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle cell migration.", + "xrefs" : [ "CL:0000192", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014911", "lbl" : "positive regulation of smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.", + "xrefs" : [ "CL:0000192", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014912", "lbl" : "negative regulation of smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.", + "xrefs" : [ "CL:0000192", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015031", "lbl" : "protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015075", + "lbl" : "monoatomic ion transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of an ion from one side of a membrane to the other.", + "xrefs" : [ "GOC:dgf", "GOC:mtg_transport", "ISBN:0815340729" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015106", + "lbl" : "bicarbonate transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "RHEA:28695" + }, { + "val" : "Reactome:R-HSA-2752067" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015125", + "lbl" : "bile acid transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-194079" + }, { + "val" : "Reactome:R-HSA-194083" + }, { + "val" : "Reactome:R-HSA-194130" + }, { + "val" : "Reactome:R-HSA-5661184" + }, { + "val" : "Reactome:R-HSA-5661198" + }, { + "val" : "Reactome:R-HSA-9733964" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015144", + "lbl" : "carbohydrate transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of carbohydrate from one side of a membrane to the other.", + "xrefs" : [ "GOC:jl", "GOC:mtg_transport", "ISBN:0815340729" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015149", + "lbl" : "hexose transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other.", + "xrefs" : [ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-189242" + }, { + "val" : "Reactome:R-HSA-5638222" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015159", + "lbl" : "polysaccharide transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.", + "xrefs" : [ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015629", "lbl" : "actin cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.", + "xrefs" : [ "GOC:jl", "ISBN:0395825172", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015630", "lbl" : "microtubule cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.", + "xrefs" : [ "GOC:jl", "ISBN:0395825172" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015669", "lbl" : "gas transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015671", "lbl" : "oxygen transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015701", + "lbl" : "bicarbonate transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:krc" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015718", + "lbl" : "monocarboxylic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:krc" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015721", + "lbl" : "bile acid and bile salt transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:dph", "GOC:krc", "PMID:12663868", "PMID:14699511" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015774", "lbl" : "polysaccharide transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015833", "lbl" : "peptide transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015837", "lbl" : "amine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015849", + "lbl" : "organic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015850", "lbl" : "organic hydroxy compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015869", "lbl" : "protein-DNA complex transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015874", "lbl" : "norepinephrine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.", + "xrefs" : [ "GOC:ai", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015931", "lbl" : "nucleobase-containing compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015932", + "lbl" : "nucleobase-containing compound transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015980", + "lbl" : "energy derivation by oxidation of organic compounds", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016020", "lbl" : "membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.", + "xrefs" : [ "GOC:dos", "GOC:mah", "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Biological_membrane" + }, { + "val" : "Wikipedia:Transmembrane_protein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016042", + "lbl" : "lipid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Lipid_catabolism" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016043", "lbl" : "cellular component organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.", + "xrefs" : [ "GOC:ai", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016049", "lbl" : "cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016050", "lbl" : "vesicle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016051", "lbl" : "carbohydrate biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016052", + "lbl" : "carbohydrate catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016053", + "lbl" : "organic acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016054", + "lbl" : "organic acid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016057", "lbl" : "regulation of membrane potential in photoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon.", + "xrefs" : [ "GOC:dph", "GOC:hb", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016070", "lbl" : "RNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016192", "lbl" : "vesicle-mediated transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.", + "xrefs" : [ "GOC:ai", "GOC:mah", "ISBN:08789310662000" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016202", "lbl" : "regulation of striated muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of striated muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016321", "lbl" : "female meiosis chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016325", "lbl" : "oocyte microtubule cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:mtg_sensu", "PMID:11231123" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016331", "lbl" : "morphogenesis of embryonic epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of embryonic epithelia are generated and organized.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016477", "lbl" : "cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.", + "xrefs" : [ "GOC:cjm", "GOC:dph", "GOC:ems", "GOC:pf", "Wikipedia:Cell_migration" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_migration" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016525", "lbl" : "negative regulation of angiogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016528", "lbl" : "sarcoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Sarcoplasm" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016787", + "lbl" : "hydrolase activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "EC:3.-.-.-" + }, { + "val" : "Reactome:R-HSA-1236938" + }, { + "val" : "Reactome:R-HSA-2029475" + }, { + "val" : "Reactome:R-HSA-5694583" + }, { + "val" : "Reactome:R-HSA-5695964" + }, { + "val" : "Reactome:R-HSA-6786190" + }, { + "val" : "Reactome:R-HSA-6788295" + }, { + "val" : "Reactome:R-HSA-8938314" + }, { + "val" : "Reactome:R-HSA-8952137" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016788", + "lbl" : "hydrolase activity, acting on ester bonds", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of the hydrolysis of any ester bond.", + "xrefs" : [ "GOC:jl" ] + }, + "xrefs" : [ { + "val" : "EC:3.1.-.-" + }, { + "val" : "Reactome:R-HSA-162729" + }, { + "val" : "Reactome:R-HSA-9023617" + }, { + "val" : "Reactome:R-HSA-9023619" + }, { + "val" : "Reactome:R-HSA-9749609" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0017126", "lbl" : "nucleologenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0017145", "lbl" : "stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.", + "xrefs" : [ "GOC:jid", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0017148", "lbl" : "negative regulation of translation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0017157", "lbl" : "regulation of exocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of exocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0018958", "lbl" : "phenol-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "comments" : [ "Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds." ], + "xrefs" : [ { + "val" : "UM-BBD_pathwayID:phe" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019098", + "lbl" : "reproductive behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specific behavior of an organism that is associated with reproduction.", + "xrefs" : [ "GOC:jl", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019216", "lbl" : "regulation of lipid metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019218", + "lbl" : "regulation of steroid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019219", "lbl" : "regulation of nucleobase-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019222", "lbl" : "regulation of metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019226", "lbl" : "transmission of nerve impulse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.", + "xrefs" : [ "GOC:curators", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019228", "lbl" : "neuronal action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An action potential that occurs in a neuron.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019233", "lbl" : "sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.", + "xrefs" : [ "GOC:curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Nociception" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019318", + "lbl" : "hexose metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019319", + "lbl" : "hexose biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019320", + "lbl" : "hexose catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019336", + "lbl" : "phenol-containing compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "MetaCyc:PHENOLDEG-PWY" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019538", "lbl" : "protein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving a protein. Includes protein modification.", + "xrefs" : [ "GOC:ma" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], + "xrefs" : [ { + "val" : "Wikipedia:Protein_metabolism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019614", + "lbl" : "catechol-containing compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019725", "lbl" : "cellular homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of an internal steady state at the level of the cell.", + "xrefs" : [ "GOC:isa_complete", "GOC:jl", "ISBN:0395825172" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019752", + "lbl" : "carboxylic acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019867", "lbl" : "outer membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019882", "lbl" : "antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149", "PMID:15771591", "PMID:15928678" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Antigen_presentation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019953", "lbl" : "sexual reproduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).", + "xrefs" : [ "Wikipedia:Sexual_reproduction" ] + }, + "comments" : [ "Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times." ], + "xrefs" : [ { + "val" : "Wikipedia:Sexual_reproduction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021501", "lbl" : "prechordal plate formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021510", "lbl" : "spinal cord development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021514", "lbl" : "ventral spinal cord interneuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:11262869" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021515", "lbl" : "cell differentiation in spinal cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:11262869" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021517", "lbl" : "ventral spinal cord development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021522", "lbl" : "spinal cord motor neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:11262869" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021532", "lbl" : "neural tube patterning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021533", "lbl" : "cell differentiation in hindbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021534", "lbl" : "cell proliferation in hindbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021535", "lbl" : "cell migration in hindbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell that will reside in the hindbrain.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021545", "lbl" : "cranial nerve development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021546", "lbl" : "rhombomere development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021547", "lbl" : "midbrain-hindbrain boundary initiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:isa_complete", "GOC:jid", "GO_REF:0000021", "PMID:15541513" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021548", "lbl" : "pons development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021550", "lbl" : "medulla oblongata development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021551", "lbl" : "central nervous system morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021555", "lbl" : "midbrain-hindbrain boundary morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:15541513" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021556", "lbl" : "central nervous system formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021559", "lbl" : "trigeminal nerve development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021575", "lbl" : "hindbrain morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021576", "lbl" : "hindbrain formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021578", "lbl" : "hindbrain maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021579", "lbl" : "medulla oblongata morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021580", "lbl" : "medulla oblongata formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021582", "lbl" : "medulla oblongata maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021583", "lbl" : "pons morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021584", "lbl" : "pons formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021586", "lbl" : "pons maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021593", "lbl" : "rhombomere morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021594", "lbl" : "rhombomere formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021602", "lbl" : "cranial nerve morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021603", "lbl" : "cranial nerve formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021605", "lbl" : "cranial nerve maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021626", "lbl" : "central nervous system maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021635", "lbl" : "trigeminal nerve maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021636", "lbl" : "trigeminal nerve morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021638", "lbl" : "trigeminal nerve formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021654", "lbl" : "rhombomere boundary formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021675", "lbl" : "nerve development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021682", "lbl" : "nerve maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021700", "lbl" : "developmental maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021703", "lbl" : "locus ceruleus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021704", "lbl" : "locus ceruleus morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021705", "lbl" : "locus ceruleus formation", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0021706", - "lbl" : "locus ceruleus maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0021706", + "lbl" : "locus ceruleus maturation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021718", "lbl" : "superior olivary nucleus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021719", "lbl" : "superior olivary nucleus morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021720", "lbl" : "superior olivary nucleus formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021722", "lbl" : "superior olivary nucleus maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021732", "lbl" : "midbrain-hindbrain boundary maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:15541513" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021751", "lbl" : "salivary nucleus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:cls", "GOC:curators", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021753", "lbl" : "superior salivary nucleus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:cls", "GOC:curators", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021782", "lbl" : "glial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021903", "lbl" : "rostrocaudal neural tube patterning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the neural tube is divided into specific regions along the rostrocaudal axis.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:11262869" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021906", "lbl" : "hindbrain-spinal cord boundary formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:11262869" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021915", "lbl" : "neural tube development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021953", "lbl" : "central nervous system neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021954", "lbl" : "central nervous system neuron development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021990", "lbl" : "neural plate formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0878932437", "ISBN:0878932585", "PMID:15806586" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021999", "lbl" : "neural plate anterior/posterior regionalization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022008", "lbl" : "neurogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Generation of cells within the nervous system.", + "xrefs" : [ "GOC:cls", "GOC:curators", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Neurogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022009", "lbl" : "central nervous system vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022035", "lbl" : "rhombomere cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:15629700" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022037", "lbl" : "metencephalon development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:cls", "GOC:curators", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022402", "lbl" : "cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.", + "xrefs" : [ "GOC:isa_complete", "GOC:mtg_cell_cycle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022406", "lbl" : "membrane docking", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.", + "xrefs" : [ "GOC:isa_complete", "PMID:27875684" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022407", "lbl" : "regulation of cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022408", "lbl" : "negative regulation of cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022409", "lbl" : "positive regulation of cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of cell adhesion to another cell.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022411", "lbl" : "cellular component disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the breakdown of a cellular component.", + "xrefs" : [ "GOC:isa_complete" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022412", "lbl" : "cellular process involved in reproduction in multicellular organism", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022414", "lbl" : "reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Reproduction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022600", "lbl" : "digestive system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:isa_complete", "GOC:jid", "GOC:mtg_cardio" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022603", "lbl" : "regulation of anatomical structure morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022604", "lbl" : "regulation of cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022607", "lbl" : "cellular component assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a cellular component.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022612", "lbl" : "gland morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a gland are generated and organized.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022613", "lbl" : "ribonucleoprotein complex biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex.", + "xrefs" : [ "GOC:isa_complete", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022617", "lbl" : "extracellular matrix disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in the breakdown of the extracellular matrix.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022618", "lbl" : "protein-RNA complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0022857", + "lbl" : "transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.", + "xrefs" : [ "GOC:jid", "GOC:mtg_transport", "ISBN:0815340729" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-1236947" + }, { + "val" : "Reactome:R-HSA-429036" + }, { + "val" : "Reactome:R-HSA-434650" + }, { + "val" : "Reactome:R-HSA-5638209" + }, { + "val" : "Reactome:R-HSA-5671707" + }, { + "val" : "Reactome:R-HSA-6784434" + }, { + "val" : "Reactome:R-HSA-6784436" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0022884", + "lbl" : "macromolecule transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a macromolecule from one side of a membrane to the other.", + "xrefs" : [ "GOC:mtg_transport", "ISBN:0815340729" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0022898", + "lbl" : "regulation of transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of transmembrane transporter activity.", + "xrefs" : [ "GOC:dph", "GOC:mtg_cardio", "GOC:mtg_transport" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023019", "lbl" : "signal transduction involved in regulation of gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.", + "xrefs" : [ "GOC:mtg_signal" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023051", "lbl" : "regulation of signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a signaling process.", + "xrefs" : [ "GOC:mtg_signal" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023052", "lbl" : "signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.", + "xrefs" : [ "GOC:mtg_signal", "GOC:mtg_signaling_feb11", "GOC:signaling" ] + }, + "comments" : [ "Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023056", "lbl" : "positive regulation of signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.", + "xrefs" : [ "GOC:mtg_signal" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023057", "lbl" : "negative regulation of signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.", + "xrefs" : [ "GOC:mtg_signal" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023061", "lbl" : "signal release", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.", + "xrefs" : [ "GOC:mtg_signal" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030010", "lbl" : "establishment of cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specification and formation of anisotropic intracellular organization or cell growth patterns.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030016", "lbl" : "myofibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.", + "xrefs" : [ "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Myofibril" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030017", "lbl" : "sarcomere", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.", + "xrefs" : [ "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Sarcomere" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030029", "lbl" : "actin filament-based process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030030", "lbl" : "cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.", + "xrefs" : [ "GOC:jl", "GOC:mah", "PMID:16318917" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030031", "lbl" : "cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.", + "xrefs" : [ "GOC:jl", "GOC:mah", "PMID:18391171" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030033", "lbl" : "microvillus assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030036", "lbl" : "actin cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030048", "lbl" : "actin filament-based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030050", "lbl" : "vesicle transport along actin filament", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Movement of a vesicle along an actin filament, mediated by motor proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030054", "lbl" : "cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "GOC:mah", "ISBN:0198506732", "PMID:26820516", "PMID:28096264" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_junction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030072", "lbl" : "peptide hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of a peptide hormone from a cell.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030073", + "lbl" : "insulin secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030097", "lbl" : "hemopoiesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.", + "xrefs" : [ "GOC:dgh", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Haematopoiesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030098", "lbl" : "lymphocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.", + "xrefs" : [ "CL:0000542", "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030099", "lbl" : "myeloid cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030100", "lbl" : "regulation of endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030133", "lbl" : "transport vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.", + "xrefs" : [ "GOC:mah", "PMID:22160157" ] + }, + "comments" : [ "Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao885490876" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030141", "lbl" : "secretory granule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + }, + "comments" : [ "Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030154", "lbl" : "cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cellular_differentiation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030155", "lbl" : "regulation of cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030163", + "lbl" : "protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children." ], + "xrefs" : [ { + "val" : "Wikipedia:Protein_catabolism" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030182", "lbl" : "neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuron.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030198", "lbl" : "extracellular matrix organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030199", "lbl" : "collagen fibril organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030203", "lbl" : "glycosaminoglycan metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.", + "xrefs" : [ "ISBN:0192800981" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030212", "lbl" : "hyaluronan metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030213", "lbl" : "hyaluronan biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030214", + "lbl" : "hyaluronan catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "MetaCyc:PWY-7645" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030217", "lbl" : "T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.", + "xrefs" : [ "GOC:jid", "GOC:mah", "GO_REF:0000022" ] + }, + "comments" : [ "Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030218", "lbl" : "erythrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Erythropoiesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030219", "lbl" : "megakaryocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030224", "lbl" : "monocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030225", "lbl" : "macrophage differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030239", "lbl" : "myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of myofibrils, the repeating units of striated muscle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030261", "lbl" : "chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030262", "lbl" : "apoptotic nuclear changes", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030263", "lbl" : "apoptotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The compaction of chromatin during apoptosis.", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Pyknosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030264", "lbl" : "nuclear fragmentation involved in apoptotic nuclear change", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:mtg_apoptosis", "GOC:tb", "ISBN:0721639976" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030278", "lbl" : "regulation of ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030279", "lbl" : "negative regulation of ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030307", "lbl" : "positive regulation of cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, extent or direction of cell growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030308", "lbl" : "negative regulation of cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030312", "lbl" : "external encapsulating structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030316", "lbl" : "osteoclast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.", + "xrefs" : [ "CL:0000092", "GOC:add", "ISBN:0781735149", "PMID:12161749" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030323", "lbl" : "respiratory tube development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030324", "lbl" : "lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.", + "xrefs" : [ "GOC:jid", "UBERON:0002048" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030334", "lbl" : "regulation of cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell migration.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030335", "lbl" : "positive regulation of cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell migration.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030336", "lbl" : "negative regulation of cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030397", "lbl" : "membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030421", + "lbl" : "defecation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expulsion of feces from the rectum.", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Defecation" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030432", + "lbl" : "peristalsis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Peristalsis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030473", "lbl" : "nuclear migration along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.", + "xrefs" : [ "GOC:mah", "GOC:sgd_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030485", "lbl" : "smooth muscle contractile fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The contractile fiber of smooth muscle cells.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030573", + "lbl" : "bile acid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030574", + "lbl" : "collagen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030595", "lbl" : "leukocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a leukocyte in response to an external stimulus.", + "xrefs" : [ "GOC:add", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030658", "lbl" : "transport vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a transport vesicle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030659", "lbl" : "cytoplasmic vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a cytoplasmic vesicle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030660", "lbl" : "Golgi-associated vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030667", "lbl" : "secretory granule membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a secretory granule.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030705", "lbl" : "cytoskeleton-dependent intracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030720", "lbl" : "oocyte localization involved in germarium-derived egg chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber.", + "xrefs" : [ "GOC:mtg_sensu", "PMID:10449356" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030851", "lbl" : "granulocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.", + "xrefs" : [ "GOC:ecd", "http://life.nthu.edu.tw/~g864204/dict-search1.htm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030852", "lbl" : "regulation of granulocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of granulocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030853", "lbl" : "negative regulation of granulocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030854", "lbl" : "positive regulation of granulocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030855", "lbl" : "epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.", + "xrefs" : [ "GOC:ecd", "PMID:11839751" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030856", "lbl" : "regulation of epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030857", "lbl" : "negative regulation of epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030858", "lbl" : "positive regulation of epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030885", "lbl" : "regulation of myeloid dendritic cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency or rate of myeloid dendritic cell activation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030886", "lbl" : "negative regulation of myeloid dendritic cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030887", "lbl" : "positive regulation of myeloid dendritic cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030901", "lbl" : "midbrain development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).", + "xrefs" : [ "PMID:4975589", "PMID:4992177" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030902", "lbl" : "hindbrain development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).", + "xrefs" : [ "PMID:4975589", "PMID:4992177" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030903", "lbl" : "notochord development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030917", "lbl" : "midbrain-hindbrain boundary development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030936", "lbl" : "transmembrane collagen trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collagen trimer that passes through a lipid bilayer membrane.", + "xrefs" : [ "ISBN:0721639976" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030951", "lbl" : "establishment or maintenance of microtubule cytoskeleton polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030952", "lbl" : "establishment or maintenance of cytoskeleton polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030990", "lbl" : "intraciliary transport particle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.", + "xrefs" : [ "GOC:cilia", "GOC:kmv", "PMID:14570576", "PMID:22118932", "PMID:23945166" ] + }, + "comments" : [ "Note that we deem cilia and microtubule-based flagella to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031012", "lbl" : "extracellular matrix", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "GOC:rph", "NIF_Subcellular:nlx_subcell_20090513", "PMID:21123617", "PMID:28089324" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:nlx_subcell_20090513" + }, { + "val" : "Wikipedia:Extracellular_matrix" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031016", + "lbl" : "pancreas development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones.", + "xrefs" : [ "GOC:cvs" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Pancreas" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031017", + "lbl" : "exocrine pancreas development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.", + "xrefs" : [ "GOC:cvs" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031018", + "lbl" : "endocrine pancreas development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.", + "xrefs" : [ "GOC:cvs" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031022", "lbl" : "nuclear migration along microfilament", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031032", "lbl" : "actomyosin structure organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + }, + "comments" : [ "Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031045", "lbl" : "dense core granule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.", + "xrefs" : [ "NIF_Subcellular:sao772007592", "PMID:14690495" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao772007592" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031076", "lbl" : "embryonic camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:mah", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031090", "lbl" : "organelle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.", + "xrefs" : [ "GOC:dos", "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao830981606" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031109", "lbl" : "microtubule polymerization or depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031110", "lbl" : "regulation of microtubule polymerization or depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031111", "lbl" : "negative regulation of microtubule polymerization or depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031112", "lbl" : "positive regulation of microtubule polymerization or depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031113", "lbl" : "regulation of microtubule polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of microtubule polymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031114", "lbl" : "regulation of microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of microtubule depolymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031115", "lbl" : "negative regulation of microtubule polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031116", "lbl" : "positive regulation of microtubule polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of microtubule polymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031117", "lbl" : "positive regulation of microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031122", "lbl" : "cytoplasmic microtubule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031128", "lbl" : "developmental induction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder).", + "xrefs" : [ "GOC:cjm", "GOC:dph", "GOC:mah", "PMID:24503535" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031143", "lbl" : "pseudopodium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Pseudopod" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031175", "lbl" : "neuron projection development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031252", "lbl" : "cell leading edge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The area of a motile cell closest to the direction of movement.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031253", "lbl" : "cell projection membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.", + "xrefs" : [ "GOC:krc", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031256", "lbl" : "leading edge membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the plasma membrane surrounding the leading edge of a motile cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031268", "lbl" : "pseudopodium organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031269", "lbl" : "pseudopodium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:pg", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031270", "lbl" : "pseudopodium retraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The myosin-based contraction and retraction of a pseudopodium.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031272", "lbl" : "regulation of pseudopodium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031273", "lbl" : "negative regulation of pseudopodium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031274", "lbl" : "positive regulation of pseudopodium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031323", "lbl" : "regulation of cellular metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031324", "lbl" : "negative regulation of cellular metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031325", "lbl" : "positive regulation of cellular metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031326", "lbl" : "regulation of cellular biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031327", "lbl" : "negative regulation of cellular biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031328", "lbl" : "positive regulation of cellular biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031329", + "lbl" : "regulation of cellular catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031330", + "lbl" : "negative regulation of cellular catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031331", + "lbl" : "positive regulation of cellular catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031333", "lbl" : "negative regulation of protein-containing complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031334", "lbl" : "positive regulation of protein-containing complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein complex assembly.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031338", "lbl" : "regulation of vesicle fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vesicle fusion.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031339", "lbl" : "negative regulation of vesicle fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031340", "lbl" : "positive regulation of vesicle fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vesicle fusion.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031344", "lbl" : "regulation of cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031345", "lbl" : "negative regulation of cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031346", "lbl" : "positive regulation of cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031347", "lbl" : "regulation of defense response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a defense response.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031348", "lbl" : "negative regulation of defense response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031349", "lbl" : "positive regulation of defense response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a defense response.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031410", "lbl" : "cytoplasmic vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle found in the cytoplasm of a cell.", + "xrefs" : [ "GOC:ai", "GOC:mah", "GOC:vesicles" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao180601769" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031503", "lbl" : "protein-containing complex localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031514", "lbl" : "motile cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.", + "xrefs" : [ "GOC:cilia", "GOC:dgh", "GOC:kmv", "PMID:17009929", "PMID:20144998", "PMID:22118931" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031594", "lbl" : "neuromuscular junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.", + "xrefs" : [ "GOC:nln" ] + }, + "comments" : [ "In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1124888485" + }, { + "val" : "Wikipedia:Neuromuscular_junction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031644", "lbl" : "regulation of nervous system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031645", "lbl" : "negative regulation of nervous system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031646", "lbl" : "positive regulation of nervous system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a neurophysiological process.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031965", "lbl" : "nuclear membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.", + "xrefs" : [ "GOC:mah", "GOC:pz" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1687101204" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031967", "lbl" : "organelle envelope", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.", + "xrefs" : [ "GOC:mah", "GOC:pz" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031968", "lbl" : "organelle outer membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031974", "lbl" : "membrane-enclosed lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.", + "xrefs" : [ "GOC:add", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031981", "lbl" : "nuclear lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The volume enclosed by the nuclear inner membrane.", + "xrefs" : [ "GOC:mah", "GOC:pz" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031982", "lbl" : "vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any small, fluid-filled, spherical organelle enclosed by membrane.", + "xrefs" : [ "GOC:mah", "GOC:pz", "GOC:vesicles" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao221389602" + }, { + "val" : "Wikipedia:Vesicle_(biology)" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031987", + "lbl" : "locomotion involved in locomotory behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032024", + "lbl" : "positive regulation of insulin secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032057", "lbl" : "negative regulation of translational initiation in response to stress", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032058", "lbl" : "positive regulation of translational initiation in response to stress", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032059", "lbl" : "bleb", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.", + "xrefs" : [ "GOC:mtg_apoptosis", "PMID:12083798", "PMID:16624291", "Wikipedia:Bleb_(cell_biology)" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Bleb_(cell_biology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032060", "lbl" : "bleb assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis", "PMID:12083798", "PMID:16624291", "Wikipedia:Bleb_(cell_biology)" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032069", + "lbl" : "regulation of nuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032070", + "lbl" : "regulation of deoxyribonuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032074", + "lbl" : "negative regulation of nuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032075", + "lbl" : "positive regulation of nuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032076", + "lbl" : "negative regulation of deoxyribonuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032077", + "lbl" : "positive regulation of deoxyribonuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032101", "lbl" : "regulation of response to external stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032102", "lbl" : "negative regulation of response to external stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032103", "lbl" : "positive regulation of response to external stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of a response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032127", "lbl" : "dense core granule membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a dense core granule.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032231", "lbl" : "regulation of actin filament bundle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032232", "lbl" : "negative regulation of actin filament bundle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032233", "lbl" : "positive regulation of actin filament bundle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032239", "lbl" : "regulation of nucleobase-containing compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032240", "lbl" : "negative regulation of nucleobase-containing compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032241", "lbl" : "positive regulation of nucleobase-containing compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032252", "lbl" : "secretory granule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032253", "lbl" : "dense core granule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032271", "lbl" : "regulation of protein polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the process of creating protein polymers.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032272", "lbl" : "negative regulation of protein polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032273", "lbl" : "positive regulation of protein polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032330", "lbl" : "regulation of chondrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of chondrocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032331", "lbl" : "negative regulation of chondrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032332", "lbl" : "positive regulation of chondrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032364", + "lbl" : "intracellular oxygen homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell.", + "xrefs" : [ "GOC:rph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032365", "lbl" : "intracellular lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of lipids within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032368", "lbl" : "regulation of lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032369", "lbl" : "negative regulation of lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032370", "lbl" : "positive regulation of lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032377", "lbl" : "regulation of intracellular lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032378", "lbl" : "negative regulation of intracellular lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032379", "lbl" : "positive regulation of intracellular lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032386", "lbl" : "regulation of intracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032387", "lbl" : "negative regulation of intracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032388", "lbl" : "positive regulation of intracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032409", + "lbl" : "regulation of transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the activity of a transporter.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032410", + "lbl" : "negative regulation of transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the activity of a transporter.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032411", + "lbl" : "positive regulation of transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the activity of a transporter.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032412", + "lbl" : "regulation of monoatomic ion transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the activity of an ion transporter.", + "xrefs" : [ "GOC:mah", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032413", + "lbl" : "negative regulation of ion transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the activity of an ion transporter.", + "xrefs" : [ "GOC:mah", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032414", + "lbl" : "positive regulation of ion transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the activity of an ion transporter.", + "xrefs" : [ "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032418", "lbl" : "lysosome localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a lysosome is transported to, and/or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032432", "lbl" : "actin filament bundle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032501", "lbl" : "multicellular organismal process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process, occurring at the level of a multicellular organism, pertinent to its function.", + "xrefs" : [ "GOC:curators", "GOC:dph", "GOC:isa_complete", "GOC:tb" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032502", "lbl" : "developmental process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032528", "lbl" : "microvillus organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032530", "lbl" : "regulation of microvillus organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032534", "lbl" : "regulation of microvillus assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that modulates the formation of a microvillus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032589", "lbl" : "neuron projection membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the plasma membrane surrounding a neuron projection.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032594", "lbl" : "protein transport within lipid bilayer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein from one location to another within a lipid bilayer.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032774", "lbl" : "RNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.", + "xrefs" : [ "GOC:mah", "GOC:txnOH" ] + }, + "comments" : [ "Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032782", + "lbl" : "bile acid secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.", + "xrefs" : [ "GOC:ecd" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032787", + "lbl" : "monocarboxylic acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032790", "lbl" : "ribosome disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.", + "xrefs" : [ "GOC:mah", "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032838", "lbl" : "plasma membrane bounded cell projection cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.", + "xrefs" : [ "GOC:krc", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032868", + "lbl" : "response to insulin", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032869", + "lbl" : "cellular response to insulin stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032871", "lbl" : "regulation of karyogamy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032878", "lbl" : "regulation of establishment or maintenance of cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032879", "lbl" : "regulation of localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032880", "lbl" : "regulation of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032881", "lbl" : "regulation of polysaccharide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032885", "lbl" : "regulation of polysaccharide biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032886", "lbl" : "regulation of microtubule-based process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032890", + "lbl" : "regulation of organic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032891", + "lbl" : "negative regulation of organic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032892", + "lbl" : "positive regulation of organic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032940", "lbl" : "secretion by cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of a substance by a cell.", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Secretion" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032941", + "lbl" : "secretion by tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of a substance by a tissue.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032943", "lbl" : "mononuclear cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032944", "lbl" : "regulation of mononuclear cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032945", "lbl" : "negative regulation of mononuclear cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032946", "lbl" : "positive regulation of mononuclear cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032956", "lbl" : "regulation of actin cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032963", "lbl" : "collagen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032964", "lbl" : "collagen biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032965", "lbl" : "regulation of collagen biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032966", "lbl" : "negative regulation of collagen biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032967", "lbl" : "positive regulation of collagen biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032970", "lbl" : "regulation of actin filament-based process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032984", "lbl" : "protein-containing complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a protein-containing macromolecular complex into its constituent components.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032986", "lbl" : "protein-DNA complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a protein-DNA complex into its constituent components.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032988", "lbl" : "protein-RNA complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a protein-RNA complex into its constituent components.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032989", "lbl" : "cellular anatomical entity morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032991", "lbl" : "protein-containing complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.", + "xrefs" : [ "GOC:dos", "GOC:mah" ] + }, + "comments" : [ "A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032993", "lbl" : "protein-DNA complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macromolecular complex containing both protein and DNA molecules.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032997", "lbl" : "Fc receptor complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033001", "lbl" : "Fc-gamma receptor III complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:11244038", "PMID:12413532" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033002", "lbl" : "muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a muscle cell population by cell division.", + "xrefs" : [ "CL:0000187", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033028", "lbl" : "myeloid cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.", + "xrefs" : [ "CL:0000763", "GOC:add", "GOC:mtg_apoptosis", "PMID:11292031", "PMID:15330259", "PMID:17133093" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033032", "lbl" : "regulation of myeloid cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033033", "lbl" : "negative regulation of myeloid cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033034", "lbl" : "positive regulation of myeloid cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033036", "lbl" : "macromolecule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a macromolecule is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033037", "lbl" : "polysaccharide localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a polysaccharide is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033043", "lbl" : "regulation of organelle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033044", "lbl" : "regulation of chromosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033045", "lbl" : "regulation of sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of sister chromatid segregation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033046", "lbl" : "negative regulation of sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033047", "lbl" : "regulation of mitotic sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033048", "lbl" : "negative regulation of mitotic sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033059", "lbl" : "cellular pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The deposition or aggregation of coloring matter in a cell.", + "xrefs" : [ "GOC:mtg_MIT_16mar07" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033157", "lbl" : "regulation of intracellular protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033238", "lbl" : "regulation of amine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033239", "lbl" : "negative regulation of amine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033240", "lbl" : "positive regulation of amine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0033241", + "lbl" : "regulation of amine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0033242", + "lbl" : "negative regulation of amine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0033243", + "lbl" : "positive regulation of amine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033278", "lbl" : "cell proliferation in midbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.", + "xrefs" : [ "GOC:dgf", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033363", "lbl" : "secretory granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033365", "lbl" : "protein localization to organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within an organelle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033366", "lbl" : "protein localization to secretory granule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a secretory granule.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033371", "lbl" : "T cell secretory granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0033500", + "lbl" : "carbohydrate homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033604", "lbl" : "negative regulation of catecholamine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033605", "lbl" : "positive regulation of catecholamine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033750", "lbl" : "ribosome localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a ribosome is transported to, and/or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033762", "lbl" : "response to glucagon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033993", "lbl" : "response to lipid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034067", "lbl" : "protein localization to Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034101", "lbl" : "erythrocyte homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process of regulating the production and elimination of erythrocytes within an organism.", + "xrefs" : [ "GOC:add", "PMID:10694114", "PMID:14754397" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034103", "lbl" : "regulation of tissue remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of tissue remodeling.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034104", "lbl" : "negative regulation of tissue remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034105", "lbl" : "positive regulation of tissue remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of tissue remodeling.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034219", "lbl" : "carbohydrate transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a carbohydrate is transported across a membrane.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034220", "lbl" : "monoatomic ion transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034242", "lbl" : "negative regulation of syncytium formation by plasma membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034248", "lbl" : "regulation of amide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034249", "lbl" : "negative regulation of amide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034250", "lbl" : "positive regulation of amide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0034251", + "lbl" : "regulation of amide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0034252", + "lbl" : "negative regulation of amide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0034253", + "lbl" : "positive regulation of amide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034329", "lbl" : "cell junction assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034330", "lbl" : "cell junction organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034349", "lbl" : "glial cell apoptotic process", - "type" : "CLASS" - }, { + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.", + "xrefs" : [ "CL:0000125", "GOC:mtg_apoptosis", "GOC:sart" ] + } + } + }, { "id" : "http://purl.obolibrary.org/obo/GO_0034350", "lbl" : "regulation of glial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034351", "lbl" : "negative regulation of glial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034352", "lbl" : "positive regulation of glial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034390", "lbl" : "smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels.", + "xrefs" : [ "CL:0000192", "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034391", "lbl" : "regulation of smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034392", "lbl" : "negative regulation of smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034393", "lbl" : "positive regulation of smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034436", "lbl" : "glycoprotein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034486", "lbl" : "vacuolar transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a solute is transported from one side of the vacuolar membrane to the other.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034502", "lbl" : "protein localization to chromosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034504", "lbl" : "protein localization to nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein transports or maintains the localization of another protein to the nucleus.", + "xrefs" : [ "GOC:ecd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034654", "lbl" : "nucleobase-containing compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0034655", + "lbl" : "nucleobase-containing compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034762", "lbl" : "regulation of transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034763", "lbl" : "negative regulation of transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034764", "lbl" : "positive regulation of transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034765", "lbl" : "regulation of monoatomic ion transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034766", "lbl" : "negative regulation of monoatomic ion transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034767", "lbl" : "positive regulation of monoatomic ion transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034769", "lbl" : "basement membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.", + "xrefs" : [ "GOC:sart", "PMID:17301221" ] + }, + "comments" : [ "Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035050", "lbl" : "embryonic heart tube development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035051", "lbl" : "cardiocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035082", "lbl" : "axoneme assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.", + "xrefs" : [ "GOC:bf", "GOC:cilia", "GOC:jl", "ISBN:0815316194" ] + }, + "comments" : [ "Note that cilia and eukaryotic flagella are deemed to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035107", "lbl" : "appendage morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.", + "xrefs" : [ "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035112", "lbl" : "genitalia morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035148", "lbl" : "tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035190", "lbl" : "syncytial nuclear migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex.", + "xrefs" : [ "GOC:bf", "ISBN:0879694238", "PMID:8314839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035234", "lbl" : "ectopic germ cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.", + "xrefs" : [ "PMID:12814944" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035239", "lbl" : "tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.", + "xrefs" : [ "GOC:bf", "PMID:14624839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035260", "lbl" : "internal genitalia morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.", + "xrefs" : [ "PMID:24793987", "PMID:25247640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035261", "lbl" : "external genitalia morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals.", + "xrefs" : [ "PMID:24793987", "PMID:25247640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035262", "lbl" : "gonad morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.", + "xrefs" : [ "ISBN:0198612001" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035264", "lbl" : "multicellular organism growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an entire multicellular organism, as opposed to cell growth.", + "xrefs" : [ "GOC:bf", "GOC:curators", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035265", "lbl" : "organ growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.", + "xrefs" : [ "GOC:bf", "ISBN:0471245208", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035270", "lbl" : "endocrine system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.", + "xrefs" : [ "GOC:bf", "Wikipedia:Development_of_the_endocrine_system" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035272", "lbl" : "exocrine system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system.", + "xrefs" : [ "GOC:bf", "Wikipedia:Exocrine_gland" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035282", "lbl" : "segmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.", + "xrefs" : [ "PMID:10611687", "PMID:9706689" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Segmentation_(biology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035290", "lbl" : "trunk segmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8.", + "xrefs" : [ "PMID:1360402" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035295", "lbl" : "tube development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.", + "xrefs" : [ "PMID:12526790" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035372", "lbl" : "protein localization to microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained at, a microtubule.", + "xrefs" : [ "GOC:bf", "GOC:lb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035418", "lbl" : "protein localization to synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035441", "lbl" : "cell migration involved in vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035556", "lbl" : "intracellular signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.", + "xrefs" : [ "GOC:bf", "GOC:jl", "GOC:signaling", "ISBN:3527303782" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035577", "lbl" : "azurophil granule membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.", + "xrefs" : [ "GOC:bf", "PMID:17152095" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035592", "lbl" : "establishment of protein localization to extracellular region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location within the extracellular region.", + "xrefs" : [ "GOC:BHF", "GOC:bf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035622", + "lbl" : "intrahepatic bile duct development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).", + "xrefs" : [ "GOC:bf", "PMID:20614624" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035628", + "lbl" : "cystic duct development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct.", + "xrefs" : [ "PMID:20614624" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035645", + "lbl" : "enteric smooth muscle cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine.", + "xrefs" : [ "CL:0002504", "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035701", "lbl" : "hematopoietic stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.", + "xrefs" : [ "CL:0000037", "GOC:BHF", "PMID:20234092" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035702", "lbl" : "monocyte homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "CL:0000576", "GOC:BHF", "PMID:18832716" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035735", "lbl" : "intraciliary transport involved in cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.", + "xrefs" : [ "GOC:bf", "GOC:cilia" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035736", "lbl" : "cell proliferation involved in compound eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis.", + "xrefs" : [ "GOC:bf", "GOC:sart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035767", "lbl" : "endothelial cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).", + "xrefs" : [ "CL:0000115", "GOC:BHF" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035773", + "lbl" : "insulin secretion involved in cellular response to glucose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus.", + "xrefs" : [ "GOC:bf", "GOC:yaf", "PMID:8492079" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035774", + "lbl" : "positive regulation of insulin secretion involved in cellular response to glucose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.", + "xrefs" : [ "GOC:bf", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035779", "lbl" : "angioblast cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells).", + "xrefs" : [ "CL:0000566", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035805", "lbl" : "egg coat", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.", + "xrefs" : [ "PMID:16944418", "PMID:17163408" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035844", + "lbl" : "cloaca development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates.", + "xrefs" : [ "GOC:dgh", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035855", "lbl" : "megakaryocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.", + "xrefs" : [ "CL:0000556", "GOC:BHF", "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035869", "lbl" : "ciliary transition zone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.", + "xrefs" : [ "GOC:cilia", "GOC:kmv", "PMID:21422230" ] + }, + "comments" : [ "Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035883", "lbl" : "enteroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.", + "xrefs" : [ "CL:0000164", "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035886", "lbl" : "vascular associated smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.", + "xrefs" : [ "GOC:sl", "PMID:16151017", "PMID:18267954" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035887", "lbl" : "aortic smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035904", "lbl" : "aorta development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0000062", "UBERON:0000947", "Wikipedia:Aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035905", "lbl" : "ascending aorta development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0002570", "UBERON:0001496", "Wikipedia:Ascending_aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035906", "lbl" : "descending aorta development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0002571", "UBERON:0001514", "Wikipedia:Descending_aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035907", "lbl" : "dorsal aorta development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "UBERON:0005805", "Wikipedia:Aorta", "ZFA:0000014" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035909", "lbl" : "aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0000062", "UBERON:0000947", "Wikipedia:Aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035910", "lbl" : "ascending aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0002570", "UBERON:0001496", "Wikipedia:Ascending_aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035911", "lbl" : "descending aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0002571", "UBERON:0001514", "Wikipedia:Descending_aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035912", "lbl" : "dorsal aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "UBERON:0005805", "Wikipedia:Aorta", "ZFA:0000014" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035914", "lbl" : "skeletal muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.", + "xrefs" : [ "CL:0000188", "GOC:BHF", "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035929", "lbl" : "steroid hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of any steroid that acts as a hormone into the circulatory system.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035935", "lbl" : "androgen secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035987", "lbl" : "endodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.", + "xrefs" : [ "CL:0000223", "GOC:yaf", "PMID:17624332" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035989", "lbl" : "tendon development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.", + "xrefs" : [ "GOC:yaf", "PMID:21412429", "UBERON:0000043" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035992", "lbl" : "tendon formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts.", + "xrefs" : [ "GOC:yaf", "PMID:17567668", "UBERON:0000043" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036035", "lbl" : "osteoclast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.", + "xrefs" : [ "CL:0000092", "GOC:bf", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036072", "lbl" : "direct ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues.", + "xrefs" : [ "GO_REF:0000034" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036093", "lbl" : "germ cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population.", + "xrefs" : [ "CL:0000586", "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036145", "lbl" : "dendritic cell homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "CL:0000451", "GOC:uh", "PMID:12570827", "PMID:19176316" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036179", "lbl" : "osteoclast maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes.", + "xrefs" : [ "CL:0000092", "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036194", "lbl" : "muscle cell projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.", + "xrefs" : [ "CL:0000187", "GOC:kmv", "PMID:15930100", "PMID:22464329" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036195", "lbl" : "muscle cell projection membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the plasma membrane surrounding a muscle cell projection.", + "xrefs" : [ "CL:0000187", "GOC:kmv", "PMID:15930100", "PMID:22464329" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036230", "lbl" : "granulocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "CL:0000094", "GOC:nhn" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036293", "lbl" : "response to decreased oxygen levels", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.", + "xrefs" : [ "GOC:al" ] + }, + "comments" : [ "This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0036333", + "lbl" : "hepatocyte homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules.", + "xrefs" : [ "CL:0000182", "GOC:nhn", "PMID:19878874" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036334", "lbl" : "epidermal stem cell homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells.", + "xrefs" : [ "CL:1000428", "GOC:nhn", "PMID:17666529" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036336", "lbl" : "dendritic cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a dendritic cell within or between different tissues and organs of the body.", + "xrefs" : [ "CL:0000451", "GOC:nhn", "PMID:19339990" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0036342", + "lbl" : "post-anal tail morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.", + "xrefs" : [ "GOC:bf", "GOC:kmv", "Wikipedia:Chordate" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036477", "lbl" : "somatodendritic compartment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.", + "xrefs" : [ "GOC:PARL", "GOC:pad" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036484", "lbl" : "trunk neural crest cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "GOC:mat", "PMID:2387238" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036504", "lbl" : "Golgi membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "PMID:12473691" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040007", "lbl" : "growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an entire organism, a part of an organism or a cell.", + "xrefs" : [ "GOC:bf", "GOC:ma" ] + }, + "comments" : [ "See also the biological process term 'cell growth ; GO:0016049'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040008", "lbl" : "regulation of growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.", + "xrefs" : [ "GOC:ems", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040011", "lbl" : "locomotion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Self-propelled movement of a cell or organism from one location to another.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040012", "lbl" : "regulation of locomotion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.", + "xrefs" : [ "GOC:ems" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040013", "lbl" : "negative regulation of locomotion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040014", "lbl" : "regulation of multicellular organism growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040015", "lbl" : "negative regulation of multicellular organism growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040016", "lbl" : "embryonic cleavage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first few specialized divisions of an activated animal egg.", + "xrefs" : [ "GOC:clt", "ISBN:0070524300" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040017", "lbl" : "positive regulation of locomotion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040018", "lbl" : "positive regulation of multicellular organism growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040019", "lbl" : "positive regulation of embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of embryonic development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040020", "lbl" : "regulation of meiotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.", + "xrefs" : [ "GOC:ems", "GOC:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040034", "lbl" : "regulation of development, heterochronic", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.", + "xrefs" : [ "PMID:9442909" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042063", "lbl" : "gliogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.", + "xrefs" : [ "GOC:dgh", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042065", "lbl" : "glial cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042069", "lbl" : "regulation of catecholamine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042073", "lbl" : "intraciliary transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.", + "xrefs" : [ "GOC:cilia", "GOC:kmv", "PMID:17981739", "PMID:18180368", "PMID:22869374" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ], + "xrefs" : [ { + "val" : "Wikipedia:Intraflagellar_transport" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042074", "lbl" : "cell migration involved in gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).", + "xrefs" : [ "GOC:jl", "PMID:16099638" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042078", "lbl" : "germ-line stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.", + "xrefs" : [ "GOC:jid", "PMID:2279698" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042098", "lbl" : "T cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a T cell population by cell division. Follows T cell activation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042102", "lbl" : "positive regulation of T cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of T cell proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042103", "lbl" : "positive regulation of T cell homeostatic proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of resting T cell proliferation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042110", "lbl" : "T cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042116", "lbl" : "macrophage activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149", "PMID:14506301" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042117", "lbl" : "monocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042118", "lbl" : "endothelial cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149", "PMID:12851652", "PMID:14581484" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042127", "lbl" : "regulation of cell population proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042129", "lbl" : "regulation of T cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of T cell proliferation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042130", "lbl" : "negative regulation of T cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of T cell proliferation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042157", "lbl" : "lipoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042158", "lbl" : "lipoprotein biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042159", + "lbl" : "lipoprotein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042175", "lbl" : "nuclear outer membrane-endoplasmic reticulum membrane network", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.", + "xrefs" : [ "GOC:bf", "GOC:jl", "GOC:mah", "GOC:mcc", "GOC:pr", "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042176", + "lbl" : "regulation of protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.", + "xrefs" : [ "GOC:go_curators", "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042177", + "lbl" : "negative regulation of protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "GOC:obol", "GO_REF:0000058", "PMID:24785082" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042180", + "lbl" : "cellular ketone metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.", + "xrefs" : [ "GOC:jl", "ISBN:0787650153" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042181", + "lbl" : "ketone biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042182", + "lbl" : "ketone catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042221", "lbl" : "response to chemical", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.", + "xrefs" : [ "GOC:jl" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042254", "lbl" : "ribosome biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.", + "xrefs" : [ "GOC:ma", "PMID:26404467", "Wikipedia:Ribosome_biogenesis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042255", "lbl" : "ribosome assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.", + "xrefs" : [ "GOC:ma", "PMID:30467428" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042330", "lbl" : "taxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a motile cell or organism in response to an external stimulus.", + "xrefs" : [ "GOC:jl", "ISBN:0192801023" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Taxis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042391", "lbl" : "regulation of membrane potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.", + "xrefs" : [ "GOC:jl", "GOC:mtg_cardio", "GOC:tb", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042401", "lbl" : "biogenic amine biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.", + "xrefs" : [ "GOC:jl", "ISBN:0395825172" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042402", + "lbl" : "cellular biogenic amine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.", + "xrefs" : [ "GOC:go_curators", "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042415", "lbl" : "norepinephrine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042421", "lbl" : "norepinephrine biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042422", + "lbl" : "norepinephrine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Norepinephrine#Degradation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042423", "lbl" : "catecholamine biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Catecholamines" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042424", + "lbl" : "catecholamine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042427", "lbl" : "serotonin biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Serotonin" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042428", "lbl" : "serotonin metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042429", + "lbl" : "serotonin catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042430", "lbl" : "indole-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton.", + "xrefs" : [ "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042435", "lbl" : "indole-containing compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042436", + "lbl" : "indole-containing compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042461", "lbl" : "photoreceptor cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042462", "lbl" : "eye photoreceptor cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.", + "xrefs" : [ "GOC:jl", "ISBN:0192800981" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042478", "lbl" : "regulation of eye photoreceptor cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of eye photoreceptor development.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042479", "lbl" : "positive regulation of eye photoreceptor cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042480", "lbl" : "negative regulation of eye photoreceptor cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042551", "lbl" : "neuron maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.", + "xrefs" : [ "GOC:dph", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042582", "lbl" : "azurophil granule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primary lysosomal granule readily stainable with a Romanowsky stain.", + "xrefs" : [ "GOC:jl", "PMID:17152095", "PMID:28717070", "PMID:5914694", "WIKIPEDIA:Azurophilic_granule" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042588", + "lbl" : "zymogen granule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042589", + "lbl" : "zymogen granule membrane", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a zymogen granule.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042592", "lbl" : "homeostatic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of an internal steady state.", + "xrefs" : [ "GOC:jl", "ISBN:0395825172" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042593", + "lbl" : "glucose homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042611", "lbl" : "MHC protein complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.", + "xrefs" : [ "GOC:add", "GOC:jl", "ISBN:0781735149", "PMID:15928678", "PMID:16153240" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042613", "lbl" : "MHC class II protein complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.", + "xrefs" : [ "GOC:add", "GOC:jl", "ISBN:0120781859", "PMID:15928678" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042641", "lbl" : "actomyosin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any complex of actin, myosin, and accessory proteins.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042670", "lbl" : "retinal cone cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042692", "lbl" : "muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.", + "xrefs" : [ "CL:0000187", "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042742", "lbl" : "defense response to bacterium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042886", "lbl" : "amide transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042887", + "lbl" : "amide transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042953", "lbl" : "lipoprotein transport", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0042981", - "lbl" : "regulation of apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042981", + "lbl" : "regulation of apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the occurrence or rate of cell death by apoptotic process.", + "xrefs" : [ "GOC:jl", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042995", "lbl" : "cell projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A prolongation or process extending from a cell, e.g. a flagellum or axon.", + "xrefs" : [ "GOC:jl", "PMID:16318917" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042996", "lbl" : "regulation of Golgi to plasma membrane protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042997", "lbl" : "negative regulation of Golgi to plasma membrane protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042998", "lbl" : "positive regulation of Golgi to plasma membrane protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043001", "lbl" : "Golgi to plasma membrane protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.", + "xrefs" : [ "ISBN:0716731363" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043005", "lbl" : "neuron projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.", + "xrefs" : [ "GOC:jl", "PMID:3077060" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao867568886" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043009", "lbl" : "chordate embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.", + "xrefs" : [ "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043010", "lbl" : "camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043011", "lbl" : "myeloid dendritic cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.", + "xrefs" : [ "CL:0000782", "GOC:jl" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Dendritic_cell" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043025", "lbl" : "neuronal cell body", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1044911821" + }, { + "val" : "Wikipedia:Soma_(biology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043029", "lbl" : "T cell homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043030", "lbl" : "regulation of macrophage activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency or rate of macrophage activation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043031", "lbl" : "negative regulation of macrophage activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043032", "lbl" : "positive regulation of macrophage activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stimulates, induces or increases the rate of macrophage activation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043043", "lbl" : "peptide biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide.", + "xrefs" : [ "GOC:dph", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043062", "lbl" : "extracellular structure organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043065", "lbl" : "positive regulation of apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.", + "xrefs" : [ "GOC:jl", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043066", "lbl" : "negative regulation of apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.", + "xrefs" : [ "GOC:jl", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043067", "lbl" : "regulation of programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043068", "lbl" : "positive regulation of programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043069", "lbl" : "negative regulation of programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043073", "lbl" : "germ cell nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The nucleus of a germ cell, a reproductive cell in multicellular organisms.", + "xrefs" : [ "CL:0000586", "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043085", + "lbl" : "positive regulation of catalytic activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the activity of an enzyme.", + "xrefs" : [ "GOC:ebc", "GOC:jl", "GOC:tb", "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043086", + "lbl" : "negative regulation of catalytic activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the activity of an enzyme.", + "xrefs" : [ "GOC:ebc", "GOC:jl", "GOC:tb", "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043129", "lbl" : "surfactant homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid.", + "xrefs" : [ "PMID:23708874", "PMID:9751757" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043133", + "lbl" : "hindgut contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine.", + "xrefs" : [ "GOC:jl", "GOC:mtg_muscle", "UBERON:0001046" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043134", + "lbl" : "regulation of hindgut contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.", + "xrefs" : [ "GOC:jl", "UBERON:0001046" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043143", "lbl" : "regulation of translation by machinery localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043170", "lbl" : "macromolecule metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043171", + "lbl" : "peptide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043207", "lbl" : "response to external biotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043226", "lbl" : "organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1539965131" + }, { + "val" : "Wikipedia:Organelle" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043227", "lbl" : "membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao414196390" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043228", "lbl" : "non-membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1456184038" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043229", "lbl" : "intracellular organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043230", "lbl" : "extracellular organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.", + "xrefs" : [ "GOC:jl", "PMID:9914479" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043231", "lbl" : "intracellular membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043232", "lbl" : "intracellular non-membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043233", "lbl" : "organelle lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.", + "xrefs" : [ "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043242", "lbl" : "negative regulation of protein-containing complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043243", "lbl" : "positive regulation of protein-containing complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043244", "lbl" : "regulation of protein-containing complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043249", "lbl" : "erythrocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.", + "xrefs" : [ "GOC:devbiol", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043254", "lbl" : "regulation of protein-containing complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein complex assembly.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043255", "lbl" : "regulation of carbohydrate biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043264", "lbl" : "extracellular non-membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043269", "lbl" : "regulation of monoatomic ion transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043270", "lbl" : "positive regulation of monoatomic ion transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043271", "lbl" : "negative regulation of monoatomic ion transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043292", "lbl" : "contractile muscle fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.", + "xrefs" : [ "GOC:go_curators", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043362", "lbl" : "nucleate erythrocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus.", + "xrefs" : [ "GOC:devbiol", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043363", "lbl" : "nucleate erythrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043434", "lbl" : "response to peptide hormone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.", + "xrefs" : [ "PMID:11027914", "PMID:15134857", "Wikipedia:Peptide_hormone" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043436", + "lbl" : "oxoacid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).", + "xrefs" : [ "Wikipedia:Oxyacid" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043467", + "lbl" : "regulation of generation of precursor metabolites and energy", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043470", + "lbl" : "regulation of carbohydrate catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates.", + "xrefs" : [ "GOC:mlg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043473", "lbl" : "pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043500", "lbl" : "muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.", + "xrefs" : [ "GOC:mtg_muscle", "PMID:11181628", "PMID:11449884", "PMID:12605307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043501", "lbl" : "skeletal muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals.", + "xrefs" : [ "GOC:mtg_muscle", "PMID:11181628", "PMID:11449884", "PMID:12605307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043502", "lbl" : "regulation of muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle adaptation.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043523", "lbl" : "regulation of neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043524", "lbl" : "negative regulation of neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043525", "lbl" : "positive regulation of neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043534", "lbl" : "blood vessel endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis.", + "xrefs" : [ "PMID:11166264" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043535", "lbl" : "regulation of blood vessel endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043536", "lbl" : "positive regulation of blood vessel endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043537", "lbl" : "negative regulation of blood vessel endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043542", "lbl" : "endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043576", "lbl" : "regulation of respiratory gaseous exchange", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043588", "lbl" : "skin development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.", + "xrefs" : [ "GOC:jl", "UBERON:0002097" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043589", "lbl" : "skin morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.", + "xrefs" : [ "GOC:jl", "UBERON:0002097" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043603", "lbl" : "amide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.", + "xrefs" : [ "GOC:curators" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043604", "lbl" : "amide biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.", + "xrefs" : [ "GOC:curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043605", + "lbl" : "amide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043931", "lbl" : "ossification involved in bone maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:mtg_mpo" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043932", "lbl" : "ossification involved in bone remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli.", + "xrefs" : [ "GOC:mtg_mpo", "GO_REF:0000034" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043933", "lbl" : "protein-containing complex organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044042", + "lbl" : "glucan metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044057", "lbl" : "regulation of system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044058", "lbl" : "regulation of digestive system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044060", "lbl" : "regulation of endocrine process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044062", + "lbl" : "regulation of excretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044065", "lbl" : "regulation of respiratory system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044085", "lbl" : "cellular component biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.", + "xrefs" : [ "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044087", "lbl" : "regulation of cellular component biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044088", "lbl" : "regulation of vacuole organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.", + "xrefs" : [ "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044089", "lbl" : "positive regulation of cellular component biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044090", "lbl" : "positive regulation of vacuole organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.", + "xrefs" : [ "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044091", "lbl" : "membrane biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044092", + "lbl" : "negative regulation of molecular function", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.", + "xrefs" : [ "GO:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044093", + "lbl" : "positive regulation of molecular function", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.", + "xrefs" : [ "GO:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044207", "lbl" : "translation initiation ternary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044237", "lbl" : "cellular metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways by which individual cells transform chemical substances.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044238", "lbl" : "primary metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Primary_metabolite" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044248", + "lbl" : "cellular catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044249", "lbl" : "cellular biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.", + "xrefs" : [ "GOC:jl" ] + }, + "comments" : [ "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044258", + "lbl" : "intestinal lipid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas.", + "xrefs" : [ "GOC:jl", "PMID:7018485" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044281", + "lbl" : "small molecule metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.", + "xrefs" : [ "GOC:curators", "GOC:pde", "GOC:vw" ] + }, + "comments" : [ "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044282", + "lbl" : "small molecule catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.", + "xrefs" : [ "GOC:curators", "GOC:vw" ] + }, + "comments" : [ "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044283", + "lbl" : "small molecule biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.", + "xrefs" : [ "GOC:curators", "GOC:pde", "GOC:vw" ] + }, + "comments" : [ "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044297", "lbl" : "cell body", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections." ], + "xrefs" : [ { + "val" : "FBbt:00005107" + }, { + "val" : "FMA:67301" + }, { + "val" : "Wikipedia:Cell_body" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044342", + "lbl" : "type B pancreatic cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin.", + "xrefs" : [ "GOC:jl", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044346", "lbl" : "fibroblast apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.", + "xrefs" : [ "CL:0000057", "GOC:jl", "GOC:mtg_apoptosis", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044380", "lbl" : "protein localization to cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044419", "lbl" : "biological process involved in interspecies interaction between organisms", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process evolved to enable an interaction with an organism of a different species.", + "xrefs" : [ "GOC:cc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044458", "lbl" : "motile cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a motile cilium.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000079", "PMID:19776033", "PMID:21129373", "ZFIN:dsf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044565", "lbl" : "dendritic cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.", + "xrefs" : [ "CL:0000451", "PMID:18469816" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044566", "lbl" : "chondrocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage.", + "xrefs" : [ "CL:0000138", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044703", "lbl" : "multi-organism reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A biological process that directly contributes to the process of producing new individuals, involving another organism.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044706", "lbl" : "multi-multicellular organism process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multicellular organism process which involves another multicellular organism of the same or different species.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044782", "lbl" : "cilium organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.", + "xrefs" : [ "GOC:cilia", "GOC:jl" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044872", "lbl" : "lipoprotein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a lipoprotein is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044873", "lbl" : "lipoprotein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044874", "lbl" : "lipoprotein localization to outer membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045026", "lbl" : "plasma membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.", + "xrefs" : [ "GOC:elh", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045124", "lbl" : "regulation of bone resorption", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045132", "lbl" : "meiotic chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.", + "xrefs" : [ "GOC:ai", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045137", "lbl" : "development of primary sexual characteristics", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045165", "lbl" : "cell fate commitment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate.", + "xrefs" : [ "ISBN:0716731185" ] + }, + "comments" : [ "Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045168", "lbl" : "cell-cell signaling involved in cell fate commitment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045184", "lbl" : "establishment of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045196", "lbl" : "establishment or maintenance of neuroblast polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.", + "xrefs" : [ "GOC:bf", "GOC:mah", "GOC:mtg_sensu", "PMID:19375318", "PMID:20066083" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045200", "lbl" : "establishment of neuroblast polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.", + "xrefs" : [ "GOC:bf", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045202", "lbl" : "synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.", + "xrefs" : [ "GOC:aruk", "ISBN:0198506732", "PMID:24619342", "PMID:29383328", "PMID:31998110" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao914572699" + }, { + "val" : "Wikipedia:Chemical_synapse" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045214", "lbl" : "sarcomere organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045216", "lbl" : "cell-cell junction organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045222", "lbl" : "CD4 biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045223", "lbl" : "regulation of CD4 production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045224", "lbl" : "positive regulation of CD4 production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045225", "lbl" : "negative regulation of CD4 production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045229", "lbl" : "external encapsulating structure organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045321", "lbl" : "leukocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:add" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Immunologic_activation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045444", "lbl" : "fat cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.", + "xrefs" : [ "CL:0000136", "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045445", "lbl" : "myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:go_curators", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045446", "lbl" : "endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.", + "xrefs" : [ "CL:0000115", "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045453", "lbl" : "bone resorption", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.", + "xrefs" : [ "GOC:mah", "PMID:10968780" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Bone_resorption" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045580", "lbl" : "regulation of T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of T cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045581", "lbl" : "negative regulation of T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045582", "lbl" : "positive regulation of T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of T cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045595", "lbl" : "regulation of cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045596", "lbl" : "negative regulation of cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045597", "lbl" : "positive regulation of cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045598", "lbl" : "regulation of fat cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of adipocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045599", "lbl" : "negative regulation of fat cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045600", "lbl" : "positive regulation of fat cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045601", "lbl" : "regulation of endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045602", "lbl" : "negative regulation of endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045603", "lbl" : "positive regulation of endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045604", "lbl" : "regulation of epidermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epidermal cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045605", "lbl" : "negative regulation of epidermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045606", "lbl" : "positive regulation of epidermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045619", "lbl" : "regulation of lymphocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045620", "lbl" : "negative regulation of lymphocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045621", "lbl" : "positive regulation of lymphocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045637", "lbl" : "regulation of myeloid cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myeloid cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045638", "lbl" : "negative regulation of myeloid cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045639", "lbl" : "positive regulation of myeloid cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045646", "lbl" : "regulation of erythrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of erythrocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045647", "lbl" : "negative regulation of erythrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045648", "lbl" : "positive regulation of erythrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045649", "lbl" : "regulation of macrophage differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of macrophage differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045650", "lbl" : "negative regulation of macrophage differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045651", "lbl" : "positive regulation of macrophage differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of macrophage differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045652", "lbl" : "regulation of megakaryocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045653", "lbl" : "negative regulation of megakaryocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045654", "lbl" : "positive regulation of megakaryocyte differentiation", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0045655", - "lbl" : "regulation of monocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045655", + "lbl" : "regulation of monocyte differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of monocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045656", "lbl" : "negative regulation of monocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045657", "lbl" : "positive regulation of monocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of monocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045661", "lbl" : "regulation of myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:go_curators", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045662", "lbl" : "negative regulation of myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:go_curators", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045663", "lbl" : "positive regulation of myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:go_curators", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045664", "lbl" : "regulation of neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuron differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045665", "lbl" : "negative regulation of neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045666", "lbl" : "positive regulation of neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuron differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045670", "lbl" : "regulation of osteoclast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of osteoclast differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045671", "lbl" : "negative regulation of osteoclast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045672", "lbl" : "positive regulation of osteoclast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045682", "lbl" : "regulation of epidermis development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epidermis development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045683", "lbl" : "negative regulation of epidermis development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045684", "lbl" : "positive regulation of epidermis development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epidermis development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045685", "lbl" : "regulation of glial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of glia cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045686", "lbl" : "negative regulation of glial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045687", "lbl" : "positive regulation of glial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of glia cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045719", + "lbl" : "negative regulation of glycogen biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045721", + "lbl" : "negative regulation of gluconeogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045722", + "lbl" : "positive regulation of gluconeogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gluconeogenesis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045724", "lbl" : "positive regulation of cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the formation of a cilium.", + "xrefs" : [ "GOC:cilia", "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045725", + "lbl" : "positive regulation of glycogen biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045727", "lbl" : "positive regulation of translation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045732", + "lbl" : "positive regulation of protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045759", "lbl" : "negative regulation of action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045760", "lbl" : "positive regulation of action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045765", "lbl" : "regulation of angiogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of angiogenesis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045766", "lbl" : "positive regulation of angiogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases angiogenesis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045769", "lbl" : "negative regulation of asymmetric cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045770", "lbl" : "positive regulation of asymmetric cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of asymmetric cell division.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045778", "lbl" : "positive regulation of ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045779", "lbl" : "negative regulation of bone resorption", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045780", "lbl" : "positive regulation of bone resorption", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of bone resorption.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045785", "lbl" : "positive regulation of cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell adhesion.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045786", "lbl" : "negative regulation of cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045787", "lbl" : "positive regulation of cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of progression through the cell cycle.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045806", "lbl" : "negative regulation of endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045807", "lbl" : "positive regulation of endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045818", + "lbl" : "negative regulation of glycogen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045819", + "lbl" : "positive regulation of glycogen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045822", "lbl" : "negative regulation of heart contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045823", "lbl" : "positive regulation of heart contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of heart contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045833", "lbl" : "negative regulation of lipid metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045834", "lbl" : "positive regulation of lipid metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045835", "lbl" : "negative regulation of meiotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045836", "lbl" : "positive regulation of meiotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of meiosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045839", "lbl" : "negative regulation of mitotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045840", "lbl" : "positive regulation of mitotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mitosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045843", "lbl" : "negative regulation of striated muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045844", "lbl" : "positive regulation of striated muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of striated muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045900", "lbl" : "negative regulation of translational elongation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045901", "lbl" : "positive regulation of translational elongation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of translational elongation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045904", "lbl" : "negative regulation of translational termination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045905", "lbl" : "positive regulation of translational termination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of translational termination.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045912", "lbl" : "negative regulation of carbohydrate metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045913", "lbl" : "positive regulation of carbohydrate metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045914", "lbl" : "negative regulation of catecholamine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045915", "lbl" : "positive regulation of catecholamine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045920", "lbl" : "negative regulation of exocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045921", "lbl" : "positive regulation of exocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of exocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045926", "lbl" : "negative regulation of growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045927", "lbl" : "positive regulation of growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045930", "lbl" : "negative regulation of mitotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045931", "lbl" : "positive regulation of mitotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045932", "lbl" : "negative regulation of muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045933", "lbl" : "positive regulation of muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045934", "lbl" : "negative regulation of nucleobase-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045935", "lbl" : "positive regulation of nucleobase-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045939", + "lbl" : "negative regulation of steroid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045940", + "lbl" : "positive regulation of steroid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045947", "lbl" : "negative regulation of translational initiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045948", "lbl" : "positive regulation of translational initiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of translational initiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045986", "lbl" : "negative regulation of smooth muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045987", "lbl" : "positive regulation of smooth muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045988", "lbl" : "negative regulation of striated muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045989", "lbl" : "positive regulation of striated muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of striated muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045992", "lbl" : "negative regulation of embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045995", "lbl" : "regulation of embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of embryonic development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046013", "lbl" : "regulation of T cell homeostatic proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of resting T cell proliferation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046014", "lbl" : "negative regulation of T cell homeostatic proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046189", "lbl" : "phenol-containing compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0046394", + "lbl" : "carboxylic acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0046395", + "lbl" : "carboxylic acid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046530", "lbl" : "photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:ai", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046532", "lbl" : "regulation of photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046533", "lbl" : "negative regulation of photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046534", "lbl" : "positive regulation of photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046545", "lbl" : "development of primary female sexual characteristics", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046548", "lbl" : "retinal rod cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046549", "lbl" : "retinal cone cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046620", "lbl" : "regulation of organ growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of growth of an organ of an organism.", + "xrefs" : [ "GOC:bf", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046621", "lbl" : "negative regulation of organ growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.", + "xrefs" : [ "GOC:bf", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046622", "lbl" : "positive regulation of organ growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.", + "xrefs" : [ "GOC:bf", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046649", "lbl" : "lymphocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046651", "lbl" : "lymphocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a lymphocyte population by cell division.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046660", "lbl" : "female sex differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The establishment of the sex of a female organism by physical differentiation.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046666", "lbl" : "retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Programmed cell death that occurs in the developing retina.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046667", "lbl" : "compound eye retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium.", + "xrefs" : [ "PMID:12006672" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046668", "lbl" : "regulation of retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina.", + "xrefs" : [ "GOC:ai", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046669", "lbl" : "regulation of compound eye retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046670", "lbl" : "positive regulation of retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina.", + "xrefs" : [ "GOC:ai", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046671", "lbl" : "negative regulation of retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina.", + "xrefs" : [ "GOC:ai", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046672", "lbl" : "positive regulation of compound eye retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046673", "lbl" : "negative regulation of compound eye retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0046676", + "lbl" : "negative regulation of insulin secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046716", "lbl" : "muscle cell cellular homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.", + "xrefs" : [ "GOC:mah", "PMID:3091429", "PMID:7781901" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046717", "lbl" : "acid secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of acid by a cell or a tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046785", "lbl" : "microtubule polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The addition of tubulin heterodimers to one or both ends of a microtubule.", + "xrefs" : [ "GOC:ai", "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046849", "lbl" : "bone remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.", + "xrefs" : [ "GOC:curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Bone_remodeling" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046850", "lbl" : "regulation of bone remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046851", "lbl" : "negative regulation of bone remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046852", "lbl" : "positive regulation of bone remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of bone remodeling.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046879", "lbl" : "hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046883", "lbl" : "regulation of hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046887", "lbl" : "positive regulation of hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046888", "lbl" : "negative regulation of hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046889", "lbl" : "positive regulation of lipid biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046890", "lbl" : "regulation of lipid biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046903", "lbl" : "secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of a substance by a cell or a tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046907", "lbl" : "intracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances within a cell.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0046942", + "lbl" : "carboxylic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0046943", + "lbl" : "carboxylic acid transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-390347" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0047496", "lbl" : "vesicle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.", + "xrefs" : [ "GOC:ecd", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048048", "lbl" : "embryonic eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048066", "lbl" : "developmental pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.", + "xrefs" : [ "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048070", "lbl" : "regulation of developmental pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048086", "lbl" : "negative regulation of developmental pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048087", "lbl" : "positive regulation of developmental pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048103", "lbl" : "somatic stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line.", + "xrefs" : [ "GOC:jid", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048132", "lbl" : "female germ-line stem cell asymmetric division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048144", "lbl" : "fibroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048145", "lbl" : "regulation of fibroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048146", "lbl" : "positive regulation of fibroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048147", "lbl" : "negative regulation of fibroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048193", "lbl" : "Golgi vesicle transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.", + "xrefs" : [ "GOC:jid", "ISBN:0716731363", "PMID:10219233" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048194", "lbl" : "Golgi vesicle budding", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The evagination of the Golgi membrane, resulting in formation of a vesicle.", + "xrefs" : [ "GOC:jid", "ISBN:0716731363", "PMID:10219233" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048199", "lbl" : "vesicle targeting, to, from or within Golgi", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation.", + "xrefs" : [ "GOC:jid", "GOC:mah", "ISBN:0716731363", "PMID:10219233" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048209", "lbl" : "regulation of vesicle targeting, to, from or within Golgi", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus.", + "xrefs" : [ "GOC:jid", "GOC:mah", "ISBN:0716731363", "PMID:10219233" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048243", "lbl" : "norepinephrine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system.", + "xrefs" : [ "GOC:ef", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048246", "lbl" : "macrophage chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a macrophage in response to an external stimulus.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048247", "lbl" : "lymphocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a lymphocyte in response to an external stimulus.", + "xrefs" : [ "GOC:hjd", "GOC:jid", "PMID:12391252" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048251", "lbl" : "elastic fiber assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching.", + "xrefs" : [ "GOC:jid", "PMID:10841810", "PMID:12615674" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048280", "lbl" : "vesicle fusion with Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048284", "lbl" : "organelle fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The creation of a single organelle from two or more organelles.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048285", "lbl" : "organelle fission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The creation of two or more organelles by division of one organelle.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048286", "lbl" : "lung alveolus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.", + "xrefs" : [ "GOC:mtg_lung", "PMID:9751757" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048288", "lbl" : "nuclear membrane fusion involved in karyogamy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048308", "lbl" : "organelle inheritance", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The partitioning of organelles between daughter cells at cell division.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048313", "lbl" : "Golgi inheritance", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The partitioning of Golgi apparatus between daughter cells at cell division.", + "xrefs" : [ "GOC:jid", "PMID:12851069" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048318", "lbl" : "axial mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048319", "lbl" : "axial mesoderm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the axial mesoderm are generated and organized.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048320", "lbl" : "axial mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048332", "lbl" : "mesoderm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the mesoderm are generated and organized.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048333", "lbl" : "mesodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048339", "lbl" : "paraxial mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048340", "lbl" : "paraxial mesoderm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the paraxial mesoderm are generated and organized.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048341", "lbl" : "paraxial mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048368", "lbl" : "lateral mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048369", "lbl" : "lateral mesoderm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the lateral mesoderm are generated and organized.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048370", "lbl" : "lateral mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048389", "lbl" : "intermediate mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048390", "lbl" : "intermediate mesoderm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the intermediate mesoderm are generated and organized.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048391", "lbl" : "intermediate mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048468", "lbl" : "cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048469", "lbl" : "cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048477", "lbl" : "oogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.", + "xrefs" : [ "GOC:kmv", "GOC:mtg_sensu", "GOC:pr" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Oogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048483", "lbl" : "autonomic nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands.", + "xrefs" : [ "FMA:9905", "GOC:jid", "GOC:sr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048485", "lbl" : "sympathetic nervous system development", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0048505", - "lbl" : "regulation of timing of cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter.", + "xrefs" : [ "FMA:9906", "GOC:jid", "GOC:sr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0048505", + "lbl" : "regulation of timing of cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development.", + "xrefs" : [ "GOC:bf", "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048513", "lbl" : "animal organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Organogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048514", "lbl" : "blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048518", "lbl" : "positive regulation of biological process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048519", "lbl" : "negative regulation of biological process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.", + "xrefs" : [ "GOC:jid" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0048520", + "lbl" : "positive regulation of behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.", + "xrefs" : [ "GOC:jid", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0048521", + "lbl" : "negative regulation of behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.", + "xrefs" : [ "GOC:jid", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048522", "lbl" : "positive regulation of cellular process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048523", "lbl" : "negative regulation of cellular process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048534", "lbl" : "hematopoietic or lymphoid organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.", + "xrefs" : [ "GOC:add", "GOC:rl", "ISBN:0781735149" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0048536", + "lbl" : "spleen development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048539", "lbl" : "bone marrow development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048545", "lbl" : "response to steroid hormone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048546", "lbl" : "digestive tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "PMID:12618131" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048562", "lbl" : "embryonic organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048565", "lbl" : "digestive tract development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048568", "lbl" : "embryonic organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048570", "lbl" : "notochord morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048580", "lbl" : "regulation of post-embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048581", "lbl" : "negative regulation of post-embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048582", "lbl" : "positive regulation of post-embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048583", "lbl" : "regulation of response to stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.", + "xrefs" : [ "GOC:jid" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048584", "lbl" : "positive regulation of response to stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.", + "xrefs" : [ "GOC:jid" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048585", "lbl" : "negative regulation of response to stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.", + "xrefs" : [ "GOC:jid" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048588", "lbl" : "developmental cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.", + "xrefs" : [ "GOC:go_curators", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048589", "lbl" : "developmental growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048592", "lbl" : "eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the eye are generated and organized.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048593", "lbl" : "camera-type eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048596", "lbl" : "embryonic camera-type eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the eye are generated and organized during embryonic development.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048598", "lbl" : "embryonic morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048599", "lbl" : "oocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048601", "lbl" : "oocyte morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048608", "lbl" : "reproductive structure development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048609", "lbl" : "multicellular organismal reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048627", "lbl" : "myoblast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:dph", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048628", "lbl" : "myoblast maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:dph", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048630", "lbl" : "skeletal muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size.", + "xrefs" : [ "GOC:lm", "PMID:15726494", "PMID:15907921" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048631", "lbl" : "regulation of skeletal muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle growth.", + "xrefs" : [ "GOC:lm", "PMID:15726494", "PMID:15907921" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048632", "lbl" : "negative regulation of skeletal muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth.", + "xrefs" : [ "GOC:lm", "PMID:15726494", "PMID:15907921" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048633", "lbl" : "positive regulation of skeletal muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of skeletal muscle growth.", + "xrefs" : [ "GOC:lm", "PMID:15726494", "PMID:15907921" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048634", "lbl" : "regulation of muscle organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048635", "lbl" : "negative regulation of muscle organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048636", "lbl" : "positive regulation of muscle organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048638", "lbl" : "regulation of developmental growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of developmental growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048639", "lbl" : "positive regulation of developmental growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of developmental growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048640", "lbl" : "negative regulation of developmental growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048641", "lbl" : "regulation of skeletal muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048642", "lbl" : "negative regulation of skeletal muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048643", "lbl" : "positive regulation of skeletal muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of skeletal muscle tissue development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048644", "lbl" : "muscle organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of muscle are generated and organized.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048645", "lbl" : "animal organ formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048646", "lbl" : "anatomical structure formation involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + }, + "comments" : [ "Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048659", "lbl" : "smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.", + "xrefs" : [ "CL:0000192", "GOC:ebc", "PMID:1840698" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048660", "lbl" : "regulation of smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.", + "xrefs" : [ "CL:0000192", "GOC:ebc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048661", "lbl" : "positive regulation of smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of smooth muscle cell proliferation.", + "xrefs" : [ "CL:0000192", "GOC:ebc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048662", "lbl" : "negative regulation of smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.", + "xrefs" : [ "CL:0000192", "GOC:ebc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048666", "lbl" : "neuron development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048667", "lbl" : "cell morphogenesis involved in neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048699", "lbl" : "generation of neurons", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.", + "xrefs" : [ "GOC:nln" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048705", "lbl" : "skeletal system morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the skeleton are generated and organized.", + "xrefs" : [ "GOC:dph", "GOC:dsf", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048729", "lbl" : "tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a tissue are generated and organized.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048730", "lbl" : "epidermis morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.", + "xrefs" : [ "GOC:jid", "UBERON:0001003" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048731", "lbl" : "system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048732", "lbl" : "gland development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048736", "lbl" : "appendage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.", + "xrefs" : [ "GOC:jid", "GOC:rc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048738", "lbl" : "cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:lm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048741", "lbl" : "skeletal muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.", + "xrefs" : [ "GOC:dph", "GOC:ef", "GOC:jid", "GOC:lm", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048742", "lbl" : "regulation of skeletal muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:mtg_muscle", "GOC:sm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048743", "lbl" : "positive regulation of skeletal muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:lm", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048744", "lbl" : "negative regulation of skeletal muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:lm", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048745", "lbl" : "smooth muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:lm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048749", "lbl" : "compound eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu", "Wikipedia:Eye" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048753", "lbl" : "pigment granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule.", + "xrefs" : [ "GOC:rc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048754", "lbl" : "branching morphogenesis of an epithelial tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.", + "xrefs" : [ "GOC:dgh", "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048755", "lbl" : "branching morphogenesis of a nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).", + "xrefs" : [ "GOC:dgh", "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048762", "lbl" : "mesenchymal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048770", "lbl" : "pigment granule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes.", + "xrefs" : [ "GOC:jid", "GOC:mh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048771", "lbl" : "tissue remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.", + "xrefs" : [ "GOC:ebc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048799", "lbl" : "animal organ maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048806", "lbl" : "genitalia development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048812", "lbl" : "neuron projection morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048821", "lbl" : "erythrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048823", "lbl" : "nucleate erythrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048844", "lbl" : "artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.", + "xrefs" : [ "GOC:dsf", "PMID:16740480" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048845", "lbl" : "venous blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart.", + "xrefs" : [ "GOC:dsf", "PMID:16740480" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048854", "lbl" : "brain morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).", + "xrefs" : [ "GOC:dgh", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048856", "lbl" : "anatomical structure development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.", + "xrefs" : [ "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048857", "lbl" : "neural nucleus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma.", + "xrefs" : [ "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048858", "lbl" : "cell projection morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a cell projection are generated and organized.", + "xrefs" : [ "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048859", "lbl" : "formation of anatomical boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.", + "xrefs" : [ "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048863", "lbl" : "stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.", + "xrefs" : [ "CL:0000034", "GOC:isa_complete" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Stem_cell_differentiation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048864", "lbl" : "stem cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate.", + "xrefs" : [ "CL:0000034", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048869", "lbl" : "cellular developmental process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048870", "lbl" : "cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.", + "xrefs" : [ "GOC:dgh", "GOC:dph", "GOC:isa_complete", "GOC:mlg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048871", "lbl" : "multicellular organismal-level homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048872", "lbl" : "homeostasis of number of cells", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048873", "lbl" : "homeostasis of number of cells within a tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.", + "xrefs" : [ "GOC:isa_complete" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0048878", + "lbl" : "chemical homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of an internal steady state of a chemical.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048880", "lbl" : "sensory system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048934", "lbl" : "peripheral nervous system neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048935", "lbl" : "peripheral nervous system neuron development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050000", "lbl" : "chromosome localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a chromosome is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050432", "lbl" : "catecholamine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.", + "xrefs" : [ "GOC:ai", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050433", "lbl" : "regulation of catecholamine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050658", "lbl" : "RNA transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050670", "lbl" : "regulation of lymphocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphocyte proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050671", "lbl" : "positive regulation of lymphocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of lymphocyte proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050672", "lbl" : "negative regulation of lymphocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050673", "lbl" : "epithelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.", + "xrefs" : [ "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050678", "lbl" : "regulation of epithelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial cell proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050679", "lbl" : "positive regulation of epithelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of epithelial cell proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050680", "lbl" : "negative regulation of epithelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050708", "lbl" : "regulation of protein secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050709", "lbl" : "negative regulation of protein secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050714", "lbl" : "positive regulation of protein secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050727", "lbl" : "regulation of inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050728", "lbl" : "negative regulation of inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050729", "lbl" : "positive regulation of inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the inflammatory response.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050746", "lbl" : "regulation of lipoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050747", "lbl" : "positive regulation of lipoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050748", "lbl" : "negative regulation of lipoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050764", "lbl" : "regulation of phagocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050765", "lbl" : "negative regulation of phagocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050766", "lbl" : "positive regulation of phagocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of phagocytosis.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050767", "lbl" : "regulation of neurogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050768", "lbl" : "negative regulation of neurogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050769", "lbl" : "positive regulation of neurogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050776", "lbl" : "regulation of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050777", "lbl" : "negative regulation of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050778", "lbl" : "positive regulation of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050789", "lbl" : "regulation of biological process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.", + "xrefs" : [ "GOC:ai", "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050790", + "lbl" : "regulation of catalytic activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the activity of an enzyme.", + "xrefs" : [ "GOC:ai", "GOC:ebc", "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050793", "lbl" : "regulation of developmental process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050794", "lbl" : "regulation of cellular process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050795", + "lbl" : "regulation of behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.", + "xrefs" : [ "GOC:go_curators", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050796", + "lbl" : "regulation of insulin secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of insulin.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050801", + "lbl" : "monoatomic ion homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050803", "lbl" : "regulation of synapse structure or activity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050804", "lbl" : "modulation of chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050805", "lbl" : "negative regulation of synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050806", "lbl" : "positive regulation of synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050807", "lbl" : "regulation of synapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050808", "lbl" : "synapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).", + "xrefs" : [ "GOC:ai", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050810", + "lbl" : "regulation of steroid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050832", "lbl" : "defense response to fungus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050863", "lbl" : "regulation of T cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of T cell activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050865", "lbl" : "regulation of cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050866", "lbl" : "negative regulation of cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050867", "lbl" : "positive regulation of cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050868", "lbl" : "negative regulation of T cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050870", "lbl" : "positive regulation of T cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of T cell activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050877", "lbl" : "nervous system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A organ system process carried out by any of the organs or tissues of neurological system.", + "xrefs" : [ "GOC:ai", "GOC:mtg_cardio" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050878", + "lbl" : "regulation of body fluid levels", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the levels of body fluids.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050879", "lbl" : "multicellular organismal movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism.", + "xrefs" : [ "GOC:dph", "GOC:mtg_muscle", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050881", "lbl" : "musculoskeletal movement", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7227" - } ] + "definition" : { + "val" : "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.", + "xrefs" : [ "GOC:dph" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050886", "lbl" : "endocrine process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.", + "xrefs" : [ "ISBN:0721662544" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050890", + "lbl" : "cognition", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.", + "xrefs" : [ "ISBN:0721619908" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cognition" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050896", "lbl" : "response to stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.", + "xrefs" : [ "GOC:ai", "GOC:bf" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050900", "lbl" : "leukocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a leukocyte within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:14680625", "PMID:14708592", "PMID:7507411", "PMID:8600538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050905", "lbl" : "neuromuscular process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process pertaining to the functions of the nervous and muscular systems of an organism.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050906", "lbl" : "detection of stimulus involved in sensory perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal.", + "xrefs" : [ "GOC:ai", "GOC:dos", "GOC:dph" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Transduction_(physiology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050907", "lbl" : "detection of chemical stimulus involved in sensory perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception.", + "xrefs" : [ "GOC:ai", "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050908", "lbl" : "detection of light stimulus involved in visual perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.", + "xrefs" : [ "GOC:ai", "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050920", "lbl" : "regulation of chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050921", "lbl" : "positive regulation of chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050922", "lbl" : "negative regulation of chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050931", "lbl" : "pigment cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte.", + "xrefs" : [ "GOC:dgh" ] + }, + "comments" : [ "Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050932", "lbl" : "regulation of pigment cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of pigmented cell differentiation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050941", "lbl" : "negative regulation of pigment cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050942", "lbl" : "positive regulation of pigment cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050953", "lbl" : "sensory perception of light stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050954", "lbl" : "sensory perception of mechanical stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050962", "lbl" : "detection of light stimulus involved in sensory perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light.", + "xrefs" : [ "GOC:ai", "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050968", "lbl" : "detection of chemical stimulus involved in sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050975", "lbl" : "sensory perception of touch", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Touch" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050994", + "lbl" : "regulation of lipid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050995", + "lbl" : "negative regulation of lipid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050996", + "lbl" : "positive regulation of lipid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051017", "lbl" : "actin filament bundle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051027", "lbl" : "DNA transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051033", + "lbl" : "RNA transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-203906" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051035", + "lbl" : "DNA transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051046", "lbl" : "regulation of secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051047", "lbl" : "positive regulation of secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051048", "lbl" : "negative regulation of secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051049", "lbl" : "regulation of transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051050", "lbl" : "positive regulation of transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051051", "lbl" : "negative regulation of transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051052", "lbl" : "regulation of DNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051053", "lbl" : "negative regulation of DNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051054", "lbl" : "positive regulation of DNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051055", "lbl" : "negative regulation of lipid biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051078", "lbl" : "meiotic nuclear membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051081", "lbl" : "nuclear membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled breakdown of the nuclear membranes, for example during cellular division.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051093", "lbl" : "negative regulation of developmental process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051094", "lbl" : "positive regulation of developmental process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051128", "lbl" : "regulation of cellular component organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051129", "lbl" : "negative regulation of cellular component organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051130", "lbl" : "positive regulation of cellular component organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051145", "lbl" : "smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.", + "xrefs" : [ "CL:0000192", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051146", "lbl" : "striated muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.", + "xrefs" : [ "CL:0000737", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051147", "lbl" : "regulation of muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle cell differentiation.", + "xrefs" : [ "CL:0000187", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051148", "lbl" : "negative regulation of muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation.", + "xrefs" : [ "CL:0000187", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051149", "lbl" : "positive regulation of muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.", + "xrefs" : [ "CL:0000187", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051150", "lbl" : "regulation of smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.", + "xrefs" : [ "CL:0000192", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051151", "lbl" : "negative regulation of smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation.", + "xrefs" : [ "CL:0000192", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051152", "lbl" : "positive regulation of smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation.", + "xrefs" : [ "CL:0000192", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051153", "lbl" : "regulation of striated muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation.", + "xrefs" : [ "CL:0000737", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051154", "lbl" : "negative regulation of striated muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation.", + "xrefs" : [ "CL:0000737", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051155", "lbl" : "positive regulation of striated muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.", + "xrefs" : [ "CL:0000737", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051169", "lbl" : "nuclear transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances into, out of, or within the nucleus.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Nuclear_transport" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051179", "lbl" : "localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.", + "xrefs" : [ "GOC:ai", "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051216", "lbl" : "cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:cjm", "PMID:23251424" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Chondrogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051222", "lbl" : "positive regulation of protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051223", "lbl" : "regulation of protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051224", "lbl" : "negative regulation of protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051234", "lbl" : "establishment of localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.", + "xrefs" : [ "GOC:ai", "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051236", "lbl" : "establishment of RNA localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of RNA to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051239", "lbl" : "regulation of multicellular organismal process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051240", "lbl" : "positive regulation of multicellular organismal process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051241", "lbl" : "negative regulation of multicellular organismal process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051246", "lbl" : "regulation of protein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051247", "lbl" : "positive regulation of protein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051248", "lbl" : "negative regulation of protein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051249", "lbl" : "regulation of lymphocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphocyte activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051250", "lbl" : "negative regulation of lymphocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051251", "lbl" : "positive regulation of lymphocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphocyte activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051252", "lbl" : "regulation of RNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051253", "lbl" : "negative regulation of RNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051254", "lbl" : "positive regulation of RNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051258", "lbl" : "protein polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051261", "lbl" : "protein depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051276", "lbl" : "chromosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051301", "lbl" : "cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.", + "xrefs" : [ "GOC:di", "GOC:go_curators", "GOC:pr" ] + }, + "comments" : [ "Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division." ], + "xrefs" : [ { + "val" : "Wikipedia:Cell_division" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051302", "lbl" : "regulation of cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051303", "lbl" : "establishment of chromosome localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a chromosome to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051321", "lbl" : "meiotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.", + "xrefs" : [ "GOC:ai" ] + }, + "comments" : [ "Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle." ], + "xrefs" : [ { + "val" : "Wikipedia:Meiosis" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051336", + "lbl" : "regulation of hydrolase activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051345", + "lbl" : "positive regulation of hydrolase activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051346", + "lbl" : "negative regulation of hydrolase activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051402", "lbl" : "neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.", + "xrefs" : [ "CL:0000540", "GOC:mtg_apoptosis" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051410", + "lbl" : "detoxification of nitrogen compound", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051445", "lbl" : "regulation of meiotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of progression through the meiotic cell cycle.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051446", "lbl" : "positive regulation of meiotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051447", "lbl" : "negative regulation of meiotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051450", "lbl" : "myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:ai", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051451", "lbl" : "myoblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:ai", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051469", "lbl" : "vesicle fusion with vacuole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051493", "lbl" : "regulation of cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051494", "lbl" : "negative regulation of cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051495", "lbl" : "positive regulation of cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051606", "lbl" : "detection of stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal.", + "xrefs" : [ "GOC:add", "GOC:ai", "GOC:dph", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051620", "lbl" : "norepinephrine uptake", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051621", "lbl" : "regulation of norepinephrine uptake", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051622", "lbl" : "negative regulation of norepinephrine uptake", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051623", "lbl" : "positive regulation of norepinephrine uptake", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051640", "lbl" : "organelle localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which an organelle is transported to, and/or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051641", "lbl" : "cellular localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.", + "xrefs" : [ "GOC:tb", "GOC:vw" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051645", "lbl" : "Golgi localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051647", "lbl" : "nucleus localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051648", "lbl" : "vesicle localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051649", "lbl" : "establishment of localization in cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.", + "xrefs" : [ "GOC:ai", "GOC:dos", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051650", "lbl" : "establishment of vesicle localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a vesicle to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051656", "lbl" : "establishment of organelle localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of an organelle to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051668", "lbl" : "localization within membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051674", "lbl" : "localization of cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a cell is transported to, and/or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051683", "lbl" : "establishment of Golgi localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of the Golgi to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051707", "lbl" : "response to other organism", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051716", "lbl" : "cellular response to stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.", + "xrefs" : [ "GOC:bf", "GOC:jl" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051726", "lbl" : "regulation of cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of progression through the cell cycle.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051781", "lbl" : "positive regulation of cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell division.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051782", "lbl" : "negative regulation of cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051783", "lbl" : "regulation of nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051784", "lbl" : "negative regulation of nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051785", "lbl" : "positive regulation of nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051875", "lbl" : "pigment granule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051890", "lbl" : "regulation of cardioblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051891", "lbl" : "positive regulation of cardioblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051892", "lbl" : "negative regulation of cardioblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051904", "lbl" : "pigment granule transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051905", "lbl" : "establishment of pigment granule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a pigment granule to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051930", "lbl" : "regulation of sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051931", "lbl" : "regulation of sensory perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051937", "lbl" : "catecholamine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.", + "xrefs" : [ "GOC:ai", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051952", "lbl" : "regulation of amine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051953", "lbl" : "negative regulation of amine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051954", "lbl" : "positive regulation of amine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051960", "lbl" : "regulation of nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051961", "lbl" : "negative regulation of nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051962", "lbl" : "positive regulation of nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051963", "lbl" : "regulation of synapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.", + "xrefs" : [ "GOC:ai", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051964", "lbl" : "negative regulation of synapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.", + "xrefs" : [ "GOC:ai", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051965", "lbl" : "positive regulation of synapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.", + "xrefs" : [ "GOC:ai", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051969", "lbl" : "regulation of transmission of nerve impulse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051970", "lbl" : "negative regulation of transmission of nerve impulse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051971", "lbl" : "positive regulation of transmission of nerve impulse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051983", "lbl" : "regulation of chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051984", "lbl" : "positive regulation of chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051985", "lbl" : "negative regulation of chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055001", "lbl" : "muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.", + "xrefs" : [ "CL:0000187", "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055002", "lbl" : "striated muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.", + "xrefs" : [ "CL:0000737", "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055003", "lbl" : "cardiac myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055006", "lbl" : "cardiac cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055007", "lbl" : "cardiac muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.", + "xrefs" : [ "GOC:devbiol", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055008", "lbl" : "cardiac muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of cardiac muscle tissue are generated and organized.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055009", "lbl" : "atrial cardiac muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of cardiac atrium muscle is generated and organized.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055010", "lbl" : "ventricular cardiac muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055013", "lbl" : "cardiac muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.", + "xrefs" : [ "GOC:devbiol", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055017", "lbl" : "cardiac muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055018", "lbl" : "regulation of cardiac muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055019", "lbl" : "negative regulation of cardiac muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055020", "lbl" : "positive regulation of cardiac muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055021", "lbl" : "regulation of cardiac muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle growth.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055022", "lbl" : "negative regulation of cardiac muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055023", "lbl" : "positive regulation of cardiac muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055024", "lbl" : "regulation of cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055025", "lbl" : "positive regulation of cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055026", "lbl" : "negative regulation of cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055057", "lbl" : "neuroblast division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron.", + "xrefs" : [ "PMID:11163136", "PMID:11250167" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055059", "lbl" : "asymmetric neuroblast division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0055082", + "lbl" : "intracellular chemical homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell.", + "xrefs" : [ "GOC:isa_complete", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055085", "lbl" : "transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + }, + "comments" : [ "Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0055088", + "lbl" : "lipid homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055094", "lbl" : "response to lipoprotein particle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055107", "lbl" : "Golgi to secretory granule transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055108", "lbl" : "Golgi to transport vesicle transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055117", "lbl" : "regulation of cardiac muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle contraction.", + "xrefs" : [ "GOC:ecd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055118", "lbl" : "negative regulation of cardiac muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.", + "xrefs" : [ "GOC:ecd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055123", "lbl" : "digestive system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:jid" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060021", + "lbl" : "roof of mouth development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.", + "xrefs" : [ "GOC:dph", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060037", "lbl" : "pharyngeal system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060038", "lbl" : "cardiac muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a cardiac muscle cell population by cell division.", + "xrefs" : [ "GOC:dph", "GOC:rph", "PMID:11161571" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060039", "lbl" : "pericardium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery.", + "xrefs" : [ "GOC:dph", "GOC:rph", "PMID:15138308", "PMID:16376438" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060041", "lbl" : "retina development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.", + "xrefs" : [ "GOC:bf", "GOC:dph", "ISBN:0815340729" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060042", "lbl" : "retina morphogenesis in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the retina is generated and organized.", + "xrefs" : [ "GOC:bf", "GOC:dph", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060043", "lbl" : "regulation of cardiac muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:rph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060044", "lbl" : "negative regulation of cardiac muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:rph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060045", "lbl" : "positive regulation of cardiac muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:rph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060047", "lbl" : "heart contraction", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0060048", - "lbl" : "cardiac muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060048", + "lbl" : "cardiac muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle contraction of cardiac muscle tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060136", "lbl" : "embryonic process involved in female pregnancy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060142", "lbl" : "regulation of syncytium formation by plasma membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060143", "lbl" : "positive regulation of syncytium formation by plasma membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060170", "lbl" : "ciliary membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the plasma membrane surrounding a cilium.", + "xrefs" : [ "GOC:cilia", "GOC:dph", "GOC:rph" ] + }, + "comments" : [ "Note that cilia and eukaryotic flagella are deemed to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060173", "lbl" : "limb development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.", + "xrefs" : [ "GOC:dgh", "GOC:dph", "PMID:11487378" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Limb_development" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060214", "lbl" : "endocardium formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:bf", "GOC:dph", "PMID:17722983" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060218", "lbl" : "hematopoietic stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.", + "xrefs" : [ "GOC:BHF", "GOC:bf", "GOC:dph", "GOC:rl", "PMID:15378083" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060219", "lbl" : "camera-type eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060221", "lbl" : "retinal rod cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060231", "lbl" : "mesenchymal to epithelial transition", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060249", "lbl" : "anatomical structure homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060251", "lbl" : "regulation of glial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of glial cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060252", "lbl" : "positive regulation of glial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of glial cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:sl", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060253", "lbl" : "negative regulation of glial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or decreases the rate or extent of glial cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:sl", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060255", "lbl" : "regulation of macromolecule metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060271", "lbl" : "cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.", + "xrefs" : [ "GOC:BHF", "GOC:cilia", "GOC:dph", "GOC:kmv", "GOC:pr", "GOC:vw", "ISBN:0198506732", "PMID:13978319", "PMID:27350441" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060281", "lbl" : "regulation of oocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dph", "GOC:tb", "PMID:2394318" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060282", "lbl" : "positive regulation of oocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060283", "lbl" : "negative regulation of oocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060284", "lbl" : "regulation of cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060285", "lbl" : "cilium-dependent cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.", + "xrefs" : [ "GOC:cilia", "GOC:dgh", "GOC:dph", "GOC:krc", "GOC:mlg", "GOC:mtg_cambridge_2013" ] + }, + "comments" : [ "Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060294", "lbl" : "cilium movement involved in cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Movement of cilia mediated by motor proteins that contributes to the movement of a cell.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060295", "lbl" : "regulation of cilium movement involved in cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060297", "lbl" : "regulation of sarcomere organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060298", "lbl" : "positive regulation of sarcomere organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060299", "lbl" : "negative regulation of sarcomere organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060322", "lbl" : "head development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060323", "lbl" : "head morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060324", "lbl" : "face development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060325", "lbl" : "face morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060326", "lbl" : "cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060341", "lbl" : "regulation of cellular localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060343", + "lbl" : "trabecula formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060344", + "lbl" : "liver trabecula formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060345", + "lbl" : "spleen trabecula formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060347", + "lbl" : "heart trabecula formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060348", "lbl" : "bone development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060349", "lbl" : "bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which bones are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060350", "lbl" : "endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone.", + "xrefs" : [ "GOC:dph", "PMID:11680679" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060351", "lbl" : "cartilage development involved in endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060359", "lbl" : "response to ammonium ion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:23509267" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060379", "lbl" : "cardiac muscle cell myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060404", "lbl" : "axonemal microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules.", + "xrefs" : [ "GOC:cilia", "GOC:dph", "GOC:krc", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060411", "lbl" : "cardiac septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060412", "lbl" : "ventricular septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060413", "lbl" : "atrial septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060414", "lbl" : "aorta smooth muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "GOC:dph", "Wikipedia:Aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060415", "lbl" : "muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060419", "lbl" : "heart growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of the heart.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060420", "lbl" : "regulation of heart growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060421", "lbl" : "positive regulation of heart growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060425", "lbl" : "lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the lung are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060426", "lbl" : "lung vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060427", "lbl" : "lung connective tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060428", "lbl" : "lung epithelium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060429", "lbl" : "epithelium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060431", "lbl" : "primary lung bud formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060433", "lbl" : "bronchus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060434", "lbl" : "bronchus morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060435", "lbl" : "bronchiole development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060436", "lbl" : "bronchiole morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060437", "lbl" : "lung growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060438", "lbl" : "trachea development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060439", "lbl" : "trachea morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060440", "lbl" : "trachea formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060441", "lbl" : "epithelial tube branching involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060450", + "lbl" : "positive regulation of hindgut contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060451", + "lbl" : "negative regulation of hindgut contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060452", "lbl" : "positive regulation of cardiac muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of cardiac muscle contraction.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060453", "lbl" : "regulation of gastric acid secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060454", "lbl" : "positive regulation of gastric acid secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060455", "lbl" : "negative regulation of gastric acid secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060456", "lbl" : "positive regulation of digestive system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060457", "lbl" : "negative regulation of digestive system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060458", "lbl" : "right lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060459", "lbl" : "left lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060460", "lbl" : "left lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which anatomical structures of the left lung are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060461", "lbl" : "right lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which anatomical structures of the right lung are generated and organized.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060462", "lbl" : "lung lobe development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060463", "lbl" : "lung lobe morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060464", "lbl" : "lung lobe formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060465", "lbl" : "pharynx development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.", + "xrefs" : [ "GOC:dph", "GOC:rk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060467", "lbl" : "negative regulation of fertilization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060468", "lbl" : "prevention of polyspermy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060479", "lbl" : "lung cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060485", "lbl" : "mesenchyme development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060486", "lbl" : "club cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung", "PMID:28144783" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060487", "lbl" : "lung epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060491", "lbl" : "regulation of cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of cell projection assembly.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060495", "lbl" : "cell-cell signaling involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060496", "lbl" : "mesenchymal-epithelial cell signaling involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060497", "lbl" : "mesenchymal-endodermal cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060501", "lbl" : "positive regulation of epithelial cell proliferation involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060502", "lbl" : "epithelial cell proliferation involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060509", "lbl" : "type I pneumocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060510", "lbl" : "type II pneumocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060532", "lbl" : "bronchus cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060533", "lbl" : "bronchus cartilage morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060534", "lbl" : "trachea cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060535", "lbl" : "trachea cartilage morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of cartilage in the trachea are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060536", "lbl" : "cartilage morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of cartilage are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060537", "lbl" : "muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060538", "lbl" : "skeletal muscle organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060539", "lbl" : "diaphragm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060540", "lbl" : "diaphragm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the diaphragm are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060541", "lbl" : "respiratory system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060560", "lbl" : "developmental growth involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060561", "lbl" : "apoptotic process involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that contributes to the shaping of an anatomical structure.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060562", "lbl" : "epithelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060563", "lbl" : "neuroepithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which epiblast cells acquire specialized features of neuroepithelial cells.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060571", "lbl" : "morphogenesis of an epithelial fold", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which an epithelial sheet bends along a linear axis.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060572", "lbl" : "morphogenesis of an epithelial bud", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060574", + "lbl" : "intestinal epithelial cell maturation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus.", + "xrefs" : [ "GOC:dph", "PMID:18824147" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060575", + "lbl" : "intestinal epithelial cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060576", + "lbl" : "intestinal epithelial cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060577", "lbl" : "pulmonary vein morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060578", "lbl" : "superior vena cava morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060581", "lbl" : "cell fate commitment involved in pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060591", "lbl" : "chondroblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060612", "lbl" : "adipose tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060623", "lbl" : "regulation of chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060627", "lbl" : "regulation of vesicle-mediated transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060632", "lbl" : "regulation of microtubule-based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060638", "lbl" : "mesenchymal-epithelial cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060684", "lbl" : "epithelial-mesenchymal cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060688", "lbl" : "regulation of morphogenesis of a branching structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060784", "lbl" : "regulation of cell proliferation involved in tissue homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060785", "lbl" : "regulation of apoptosis involved in tissue homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060786", "lbl" : "regulation of cell differentiation involved in tissue homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060788", "lbl" : "ectodermal placode formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060795", "lbl" : "cell fate commitment involved in formation of primary germ layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060837", "lbl" : "blood vessel endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060840", "lbl" : "artery development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060841", "lbl" : "venous blood vessel development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060842", "lbl" : "arterial endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060843", "lbl" : "venous endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060896", "lbl" : "neural plate pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060897", "lbl" : "neural plate regionalization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060900", "lbl" : "embryonic camera-type eye formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060907", "lbl" : "positive regulation of macrophage cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060914", "lbl" : "heart formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060915", "lbl" : "mesenchymal cell differentiation involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060916", "lbl" : "mesenchymal cell proliferation involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060920", "lbl" : "cardiac pacemaker cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.", + "xrefs" : [ "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060921", "lbl" : "sinoatrial node cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060922", "lbl" : "atrioventricular node cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060926", "lbl" : "cardiac pacemaker cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.", + "xrefs" : [ "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060928", "lbl" : "atrioventricular node cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060931", "lbl" : "sinoatrial node cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060932", "lbl" : "His-Purkinje system cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060933", "lbl" : "His-Purkinje system cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060935", "lbl" : "cardiac fibroblast cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060936", "lbl" : "cardiac fibroblast cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060945", "lbl" : "cardiac neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060946", "lbl" : "cardiac blood vessel endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060950", "lbl" : "cardiac glial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060952", "lbl" : "cardiac glial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060956", "lbl" : "endocardial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060958", "lbl" : "endocardial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060959", "lbl" : "cardiac neuron development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060973", "lbl" : "cell migration involved in heart development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060974", "lbl" : "cell migration involved in heart formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060976", "lbl" : "coronary vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060977", "lbl" : "coronary vasculature morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060978", "lbl" : "angiogenesis involved in coronary vascular morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060979", "lbl" : "vasculogenesis involved in coronary vascular morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060980", "lbl" : "cell migration involved in coronary vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060981", "lbl" : "cell migration involved in coronary angiogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060986", "lbl" : "endocrine hormone secretion", - "type" : "CLASS" - }, { + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of a hormone into the circulatory system.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061007", + "lbl" : "hepaticobiliary system process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061008", + "lbl" : "hepaticobiliary system development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061009", + "lbl" : "common bile duct development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine.", + "xrefs" : [ "PMID:20614624" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061010", + "lbl" : "gallbladder development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061011", + "lbl" : "hepatic duct development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct.", + "xrefs" : [ "GOC:dph", "PMID:20614624" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061017", + "lbl" : "hepatoblast differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes.", + "xrefs" : [ "GOC:dph", "PMID:15226394" ] + } + } + }, { "id" : "http://purl.obolibrary.org/obo/GO_0061024", "lbl" : "membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061025", "lbl" : "membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The membrane organization process that joins two lipid bilayers to form a single membrane.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Lipid_bilayer_fusion" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061032", "lbl" : "visceral serous pericardium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061035", "lbl" : "regulation of cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061036", "lbl" : "positive regulation of cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061037", "lbl" : "negative regulation of cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061040", "lbl" : "female gonad morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a female gonad is generated and organized.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061046", "lbl" : "regulation of branching involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061047", "lbl" : "positive regulation of branching involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061048", "lbl" : "negative regulation of branching involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061049", "lbl" : "cell growth involved in cardiac muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061050", "lbl" : "regulation of cell growth involved in cardiac muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061051", "lbl" : "positive regulation of cell growth involved in cardiac muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061052", "lbl" : "negative regulation of cell growth involved in cardiac muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061053", "lbl" : "somite development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061054", "lbl" : "dermatome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061055", "lbl" : "myotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061056", "lbl" : "sclerotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061061", "lbl" : "muscle structure development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061072", "lbl" : "iris morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061073", "lbl" : "ciliary body morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061074", "lbl" : "regulation of neural retina development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061075", "lbl" : "positive regulation of neural retina development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061076", "lbl" : "negative regulation of neural retina development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061080", "lbl" : "right horn of sinus venosus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the right horn of the sinus venosus from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061081", "lbl" : "positive regulation of myeloid leukocyte cytokine production involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061082", "lbl" : "myeloid leukocyte cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that contributes to cytokine production by a myeloid cell.", + "xrefs" : [ "GOC:dph" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061100", "lbl" : "lung neuroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium.", + "xrefs" : [ "GOC:dph", "PMID:9126746" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061101", "lbl" : "neuroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061102", "lbl" : "stomach neuroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium.", + "xrefs" : [ "GOC:dph", "PMID:18173746" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061105", "lbl" : "regulation of stomach neuroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061106", "lbl" : "negative regulation of stomach neuroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061109", "lbl" : "dense core granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061111", "lbl" : "epithelial-mesenchymal cell signaling involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061113", + "lbl" : "pancreas morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061114", + "lbl" : "branching involved in pancreas morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the branches of the pancreas are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061117", "lbl" : "negative regulation of heart growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.", + "xrefs" : [ "GOC:dph", "GOC:hjd" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061130", + "lbl" : "pancreatic bud formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061138", "lbl" : "morphogenesis of a branching epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a branched epithelium are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061140", "lbl" : "lung secretory cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061141", "lbl" : "lung ciliated cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells.", + "xrefs" : [ "GOC:cilia", "GOC:dph", "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061147", "lbl" : "endocardial endothelium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061148", "lbl" : "extracellular matrix organization involved in endocardium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061152", "lbl" : "trachea submucosa development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061153", + "lbl" : "trachea gland development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061154", "lbl" : "endothelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061155", "lbl" : "pulmonary artery endothelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061156", "lbl" : "pulmonary artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061178", + "lbl" : "regulation of insulin secretion involved in cellular response to glucose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061179", + "lbl" : "negative regulation of insulin secretion involved in cellular response to glucose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061181", "lbl" : "regulation of chondrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061182", "lbl" : "negative regulation of chondrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061183", "lbl" : "regulation of dermatome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061184", "lbl" : "positive regulation of dermatome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061185", "lbl" : "negative regulation of dermatome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061189", "lbl" : "positive regulation of sclerotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061190", "lbl" : "regulation of sclerotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061298", "lbl" : "retina vasculature development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061299", "lbl" : "retina vasculature morphogenesis in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the vasculature of the retina is generated and organized.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061303", "lbl" : "cornea development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061304", "lbl" : "retinal blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061307", "lbl" : "cardiac neural crest cell differentiation involved in heart development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart", "PMID:19705442" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061308", "lbl" : "cardiac neural crest cell development involved in heart development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061309", "lbl" : "cardiac neural crest cell development involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061323", "lbl" : "cell proliferation involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061325", "lbl" : "cell proliferation involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061337", "lbl" : "cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061343", "lbl" : "cell adhesion involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart", "PMID:16860783" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061344", "lbl" : "regulation of cell adhesion involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart", "PMID:16860783" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061351", "lbl" : "neural precursor cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061383", + "lbl" : "trabecula morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061384", + "lbl" : "heart trabecula morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061385", "lbl" : "fibroblast proliferation involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061448", "lbl" : "connective tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a connective tissue over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061450", "lbl" : "trophoblast cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061453", + "lbl" : "interstitial cell of Cajal differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061458", "lbl" : "reproductive system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061462", "lbl" : "protein localization to lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a lysosome.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061469", + "lbl" : "regulation of type B pancreatic cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061484", "lbl" : "hematopoietic stem cell homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells.", + "xrefs" : [ "GOC:dph", "PMID:21508411" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061512", "lbl" : "protein localization to cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a cilium.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061515", "lbl" : "myeloid cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061519", "lbl" : "macrophage homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "GOC:dph", "PMID:21727904" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061523", "lbl" : "cilium disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the breakdown of a cilium.", + "xrefs" : [ "GOC:cilia", "GOC:dph", "PMID:17604723", "PMID:27350441" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061525", + "lbl" : "hindgut development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061548", "lbl" : "ganglion development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061549", "lbl" : "sympathetic ganglion development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061550", "lbl" : "cranial ganglion development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061551", "lbl" : "trigeminal ganglion development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061552", "lbl" : "ganglion morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of ganglion are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061553", "lbl" : "ganglion maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061554", "lbl" : "ganglion formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061556", "lbl" : "trigeminal ganglion morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of a trigeminal ganglion is generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061557", "lbl" : "trigeminal ganglion maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061558", "lbl" : "cranial ganglion maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061559", "lbl" : "cranial ganglion morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of a cranial ganglion is generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061560", "lbl" : "cranial ganglion formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061561", "lbl" : "trigeminal ganglion formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061572", "lbl" : "actin filament bundle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061580", + "lbl" : "colon epithelial cell migration", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061581", "lbl" : "corneal epithelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061582", + "lbl" : "intestinal epithelial cell migration", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061626", "lbl" : "pharyngeal arch artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "PMID:20122914" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061792", "lbl" : "secretory granule maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "GOC:dph", "PMID:16618809" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061853", "lbl" : "regulation of neuroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuroblast migration.", + "xrefs" : [ "PMID:23149556" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061854", "lbl" : "positive regulation of neuroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuroblast migration.", + "xrefs" : [ "PMID:23149556" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061855", "lbl" : "negative regulation of neuroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration.", + "xrefs" : [ "PMID:23149556" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061900", "lbl" : "glial cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:18723082" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061938", "lbl" : "protein localization to somatodendritic compartment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment.", + "xrefs" : [ "PMID:18341993" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061951", "lbl" : "establishment of protein localization to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location in a plasma membrane.", + "xrefs" : [ "GOC:dph", "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061971", "lbl" : "replacement bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone.", + "xrefs" : [ "PMID:29852585" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061972", "lbl" : "dermal bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which bone which forms superficially in the organism are generated and organized.", + "xrefs" : [ "PMID:12588850", "PMID:15003632" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061973", "lbl" : "membrane bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which bone which forms deep in the organism are generated and organized.", + "xrefs" : [ "PMID:14579374" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0062012", + "lbl" : "regulation of small molecule metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of a small molecule metabolic process.", + "xrefs" : [ "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0062013", + "lbl" : "positive regulation of small molecule metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process.", + "xrefs" : [ "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0062014", + "lbl" : "negative regulation of small molecule metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process.", + "xrefs" : [ "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062023", "lbl" : "collagen-containing extracellular matrix", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.", + "xrefs" : [ "GOC:BHF", "GOC:rph", "PMID:21123617" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062033", "lbl" : "positive regulation of mitotic sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.", + "xrefs" : [ "PMID:12773390" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062094", "lbl" : "stomach development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ.", + "xrefs" : [ "PMID:11967278" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062149", "lbl" : "detection of stimulus involved in sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal.", + "xrefs" : [ "PMID:19837031" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062237", "lbl" : "protein localization to postsynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell.", + "xrefs" : [ "PMID:31189538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065002", "lbl" : "intracellular protein transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:isa_complete" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065003", "lbl" : "protein-containing complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065004", "lbl" : "protein-DNA complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065007", "lbl" : "biological regulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates a measurable attribute of any biological process, quality or function.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "GOC:mah", "GOC:pr", "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0065009", + "lbl" : "regulation of molecular function", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065010", "lbl" : "extracellular membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070013", "lbl" : "intracellular organelle lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organelle lumen that is part of an intracellular organelle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070050", "lbl" : "neuron cellular homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070062", "lbl" : "extracellular exosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "GOC:vesicles", "PMID:15908444", "PMID:17641064", "PMID:19442504", "PMID:19498381", "PMID:22418571", "PMID:24009894" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070091", "lbl" : "glucagon secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070092", "lbl" : "regulation of glucagon secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of glucagon.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070093", "lbl" : "negative regulation of glucagon secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070094", "lbl" : "positive regulation of glucagon secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070161", "lbl" : "anchoring junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.", + "xrefs" : [ "ISBN:0815332181" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070192", "lbl" : "chromosome organization involved in meiotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process of chromosome organization that is involved in a meiotic cell cycle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070199", "lbl" : "establishment of protein localization to chromosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location on a chromosome.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070201", "lbl" : "regulation of establishment of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070202", "lbl" : "regulation of establishment of protein localization to chromosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070227", "lbl" : "lymphocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.", + "xrefs" : [ "CL:0000542", "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070228", "lbl" : "regulation of lymphocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070229", "lbl" : "negative regulation of lymphocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070230", "lbl" : "positive regulation of lymphocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070231", "lbl" : "T cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.", + "xrefs" : [ "CL:0000084", "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070232", "lbl" : "regulation of T cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the occurrence or rate of T cell death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070233", "lbl" : "negative regulation of T cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070234", "lbl" : "positive regulation of T cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070253", "lbl" : "somatostatin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of somatostatin from secretory granules in the D cells of the pancreas.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070254", + "lbl" : "mucus secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function.", + "xrefs" : [ "GOC:add", "ISBN:068340007X", "ISBN:0721662544" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070255", + "lbl" : "regulation of mucus secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.", + "xrefs" : [ "GOC:add" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070256", + "lbl" : "negative regulation of mucus secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.", + "xrefs" : [ "GOC:add" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070257", + "lbl" : "positive regulation of mucus secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070285", "lbl" : "pigment cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate.", + "xrefs" : [ "GOC:cvs" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070341", "lbl" : "fat cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070344", "lbl" : "regulation of fat cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of fat cell proliferation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070345", "lbl" : "negative regulation of fat cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or decreases the rate or extent of fat cell proliferation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070346", "lbl" : "positive regulation of fat cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of fat cell proliferation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070365", + "lbl" : "hepatocyte differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.", + "xrefs" : [ "CL:0000182", "PMID:7588884" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070366", + "lbl" : "regulation of hepatocyte differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hepatocyte differentiation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070367", + "lbl" : "negative regulation of hepatocyte differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or decreases the rate or extent of hepatocyte differentiation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070368", + "lbl" : "positive regulation of hepatocyte differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of hepatocyte differentiation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070382", "lbl" : "exocytic vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.", + "xrefs" : [ "GOC:kad", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070482", "lbl" : "response to oxygen levels", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070483", "lbl" : "detection of hypoxia", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0070507", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070507", "lbl" : "regulation of microtubule cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070633", "lbl" : "transepithelial transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a substance from one side of an epithelium to the other.", + "xrefs" : [ "GOC:mah", "GOC:yaf", "ISBN:0716731363" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070634", "lbl" : "transepithelial ammonium transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of ammonium ions from one side of an epithelium to the other.", + "xrefs" : [ "GOC:mah", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070661", "lbl" : "leukocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a leukocyte population by cell division.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070663", "lbl" : "regulation of leukocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of leukocyte proliferation.", + "xrefs" : [ "GOC:add", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070664", "lbl" : "negative regulation of leukocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.", + "xrefs" : [ "GOC:add", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070665", "lbl" : "positive regulation of leukocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.", + "xrefs" : [ "GOC:add", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070727", "lbl" : "cellular macromolecule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070831", "lbl" : "basement membrane assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070857", + "lbl" : "regulation of bile acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070858", + "lbl" : "negative regulation of bile acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070859", + "lbl" : "positive regulation of bile acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070873", + "lbl" : "regulation of glycogen metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070874", + "lbl" : "negative regulation of glycogen metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070875", + "lbl" : "positive regulation of glycogen metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070887", "lbl" : "cellular response to chemical stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070925", "lbl" : "organelle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070977", "lbl" : "bone maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state.", + "xrefs" : [ "GOC:dph", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071168", "lbl" : "protein localization to chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071169", "lbl" : "establishment of protein localization to chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a part of a chromosome that is organized into chromatin.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071242", "lbl" : "cellular response to ammonium ion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:23509267" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071322", "lbl" : "cellular response to carbohydrate stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0071331", + "lbl" : "cellular response to hexose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0071333", + "lbl" : "cellular response to glucose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071375", "lbl" : "cellular response to peptide hormone stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071377", "lbl" : "cellular response to glucagon stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071383", "lbl" : "cellular response to steroid hormone stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071396", "lbl" : "cellular response to lipid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071417", "lbl" : "cellular response to organonitrogen compound", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071418", "lbl" : "cellular response to amine stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071425", "lbl" : "hematopoietic stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.", + "xrefs" : [ "CL:0000037", "GOC:BHF", "GOC:add", "GOC:mah", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071495", "lbl" : "cellular response to endogenous stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071621", "lbl" : "granulocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a granulocyte in response to an external stimulus.", + "xrefs" : [ "GOC:rph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071622", "lbl" : "regulation of granulocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071623", "lbl" : "negative regulation of granulocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071624", "lbl" : "positive regulation of granulocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071626", "lbl" : "mastication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of biting and mashing food with the teeth prior to swallowing.", + "xrefs" : [ "GOC:gvg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071670", "lbl" : "smooth muscle cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a smooth muscle cell in response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071671", "lbl" : "regulation of smooth muscle cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071672", "lbl" : "negative regulation of smooth muscle cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071673", "lbl" : "positive regulation of smooth muscle cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071674", "lbl" : "mononuclear cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a mononuclear cell within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071675", "lbl" : "regulation of mononuclear cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071676", "lbl" : "negative regulation of mononuclear cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071677", "lbl" : "positive regulation of mononuclear cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071692", "lbl" : "protein localization to extracellular region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071695", "lbl" : "anatomical structure maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071696", "lbl" : "ectodermal placode development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071697", "lbl" : "ectodermal placode morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071705", "lbl" : "nitrogen compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071709", "lbl" : "membrane assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071711", "lbl" : "basement membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071763", "lbl" : "nuclear membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071764", "lbl" : "nuclear outer membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071806", "lbl" : "protein transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a protein is transported across a membrane.", + "xrefs" : [ "GOC:mah", "GOC:vw" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071824", "lbl" : "protein-DNA complex organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071826", "lbl" : "protein-RNA complex organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071840", "lbl" : "cellular component organization or biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071869", "lbl" : "response to catecholamine", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071870", "lbl" : "cellular response to catecholamine stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071873", "lbl" : "response to norepinephrine", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + }, + "comments" : [ "Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071874", "lbl" : "cellular response to norepinephrine stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + }, + "comments" : [ "Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071887", "lbl" : "leukocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.", + "xrefs" : [ "CL:0000738", "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071888", "lbl" : "macrophage apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues.", + "xrefs" : [ "CL:0000235", "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071897", "lbl" : "DNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biosynthetic process resulting in the formation of DNA.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071944", "lbl" : "cell periphery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures.", + "xrefs" : [ "GOC:pdt" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071953", "lbl" : "elastic fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "PMID:20236620" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071971", "lbl" : "extracellular exosome assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm.", + "xrefs" : [ "GOC:mah", "GOC:tfm", "PMID:19442504", "PMID:27462458" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072001", + "lbl" : "renal system development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels.", + "xrefs" : [ "GOC:mtg_kidney_jan10", "GOC:yaf", "PMID:6996269" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072089", "lbl" : "stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.", + "xrefs" : [ "GOC:mtg_kidney_jan10" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072091", "lbl" : "regulation of stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.", + "xrefs" : [ "GOC:mtg_kidney_jan10" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072132", "lbl" : "mesenchyme morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells.", + "xrefs" : [ "GOC:mtg_kidney_jan10" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072175", "lbl" : "epithelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of an epithelial tube.", + "xrefs" : [ "GOC:mtg_kidney_jan10" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072201", "lbl" : "negative regulation of mesenchymal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.", + "xrefs" : [ "GOC:mtg_kidney_jan10" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072329", + "lbl" : "monocarboxylic acid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072330", + "lbl" : "monocarboxylic acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072359", "lbl" : "circulatory system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.", + "xrefs" : [ "GOC:mah", "UBERON:0001009" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072360", "lbl" : "vascular cord development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis.", + "xrefs" : [ "GOC:mah", "PMID:7084422", "ZFA:0005077" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072384", "lbl" : "organelle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072488", "lbl" : "ammonium transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072537", "lbl" : "fibroblast activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.", + "xrefs" : [ "CL:0000057", "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072560", + "lbl" : "type B pancreatic cell maturation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.", + "xrefs" : [ "CL:0000169", "GOC:BHF" ] + }, + "comments" : [ "These processes continue to 60 DPA in Gossypium spp." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072575", + "lbl" : "epithelial cell proliferation involved in liver morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072576", + "lbl" : "liver morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the liver are generated and organized.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072577", "lbl" : "endothelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal.", + "xrefs" : [ "CL:0000115", "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072592", "lbl" : "oxygen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving diatomic oxygen (O2).", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072594", "lbl" : "establishment of protein localization to organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072657", "lbl" : "protein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a specific location in a membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072659", "lbl" : "protein localization to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072665", "lbl" : "protein localization to vacuole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained at, a location in a vacuole.", + "xrefs" : [ "GOC:ecd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072666", "lbl" : "establishment of protein localization to vacuole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location in a vacuole.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072674", "lbl" : "multinuclear osteoclast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.", + "xrefs" : [ "CL:0000779", "GOC:mah", "PMID:12713016" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072676", "lbl" : "lymphocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a lymphocyte within or between different tissues and organs of the body.", + "xrefs" : [ "CL:0000542", "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072678", "lbl" : "T cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a T cell within or between different tissues and organs of the body.", + "xrefs" : [ "CL:0000084", "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072697", "lbl" : "protein localization to cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, the cell cortex.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072698", "lbl" : "protein localization to microtubule cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0080090", "lbl" : "regulation of primary metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.", + "xrefs" : [ "PMID:19211694" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0080134", "lbl" : "regulation of response to stress", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).", + "xrefs" : [ "GOC:dhl" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0080154", "lbl" : "regulation of fertilization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).", + "xrefs" : [ "GOC:DHL", "PMID:20478994" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0080171", "lbl" : "lytic vacuole organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole.", + "xrefs" : [ "PMID:20729380" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0085029", "lbl" : "extracellular matrix assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of the extracellular matrix.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086001", "lbl" : "cardiac muscle cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An action potential that occurs in a cardiac muscle cell.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086015", "lbl" : "SA node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An action potential that occurs in a sinoatrial node cardiac muscle cell.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086016", "lbl" : "AV node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An action potential that occurs in an atrioventricular node cardiac muscle cell.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086017", "lbl" : "Purkinje myocyte action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An action potential that occurs in a Purkinje myocyte.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086018", "lbl" : "SA node cell to atrial cardiac muscle cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086019", "lbl" : "cell-cell signaling involved in cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086027", "lbl" : "AV node cell to bundle of His cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086029", "lbl" : "Purkinje myocyte to ventricular cardiac muscle cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086065", "lbl" : "cell communication involved in cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086067", "lbl" : "AV node cell to bundle of His cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086068", "lbl" : "Purkinje myocyte to ventricular cardiac muscle cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086070", "lbl" : "SA node cell to atrial cardiac muscle cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090025", "lbl" : "regulation of monocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090026", "lbl" : "positive regulation of monocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate, or extent of monocyte chemotaxis.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090027", "lbl" : "negative regulation of monocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090063", "lbl" : "positive regulation of microtubule nucleation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090068", "lbl" : "positive regulation of cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090069", "lbl" : "regulation of ribosome biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090070", "lbl" : "positive regulation of ribosome biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090071", "lbl" : "negative regulation of ribosome biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090087", "lbl" : "regulation of peptide transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090091", "lbl" : "positive regulation of extracellular matrix disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090130", "lbl" : "tissue migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the population of cells that make up a tissue undergo directed movement.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090132", "lbl" : "epithelium migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the population of cells that make up an epithelium undergo directed movement.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090138", "lbl" : "regulation of actin cytoskeleton organization by cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090150", "lbl" : "establishment of protein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location in a membrane.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090162", "lbl" : "establishment of epithelial cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specification and formation of anisotropic intracellular organization of an epithelial cell.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090166", "lbl" : "Golgi disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090168", "lbl" : "Golgi reassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090170", "lbl" : "regulation of Golgi inheritance", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090171", "lbl" : "chondrocyte morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090174", "lbl" : "organelle membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of two lipid bilayers to form a single organelle membrane.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090257", "lbl" : "regulation of muscle system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090273", "lbl" : "regulation of somatostatin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090274", "lbl" : "positive regulation of somatostatin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090275", "lbl" : "negative regulation of somatostatin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090276", "lbl" : "regulation of peptide hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090277", "lbl" : "positive regulation of peptide hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090278", "lbl" : "negative regulation of peptide hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090289", "lbl" : "regulation of osteoclast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090290", "lbl" : "positive regulation of osteoclast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090291", "lbl" : "negative regulation of osteoclast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090299", "lbl" : "regulation of neural crest formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090300", "lbl" : "positive regulation of neural crest formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090301", "lbl" : "negative regulation of neural crest formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090316", "lbl" : "positive regulation of intracellular protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090317", "lbl" : "negative regulation of intracellular protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.", + "xrefs" : [ "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0090325", + "lbl" : "regulation of locomotion involved in locomotory behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.", + "xrefs" : [ "GOC:dph", "GOC:kmv", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0090326", + "lbl" : "positive regulation of locomotion involved in locomotory behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.", + "xrefs" : [ "GOC:dph", "GOC:kmv", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0090327", + "lbl" : "negative regulation of locomotion involved in locomotory behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.", + "xrefs" : [ "GOC:dph", "GOC:kmv", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0090425", + "lbl" : "acinar cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090435", "lbl" : "protein localization to nuclear envelope", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090493", "lbl" : "catecholamine uptake", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of catecholamine into a cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090497", "lbl" : "mesenchymal cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090596", "lbl" : "sensory organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:kmv", "ISBN:978-0199210893" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090685", "lbl" : "RNA localization to nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus.", + "xrefs" : [ "GOC:mah", "PMID:26305931" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090741", "lbl" : "pigment granule membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any membrane that is part of a pigment granule.", + "xrefs" : [ "PMID:11294610" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097014", "lbl" : "ciliary plasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.", + "xrefs" : [ "GOC:BHF", "GOC:cilia", "GOC:dos", "PMID:17895364" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term \"ciliary plasm\" is not linked to \"cytoplasm\"." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097026", "lbl" : "dendritic cell dendrite assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.", + "xrefs" : [ "CL:0000451", "GOC:BHF", "PMID:12200351" ] + }, + "comments" : [ "Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097028", "lbl" : "dendritic cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.", + "xrefs" : [ "CL:0000451", "GOC:pr" ] + }, + "comments" : [ "Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097048", "lbl" : "dendritic cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.", + "xrefs" : [ "CL:0000451", "GOC:BHF", "GOC:mtg_apoptosis", "PMID:15059845" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097049", "lbl" : "motor neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.", + "xrefs" : [ "CL:0000100", "GOC:BHF", "GOC:mtg_apoptosis", "PMID:14523086" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097050", + "lbl" : "type B pancreatic cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin.", + "xrefs" : [ "CL:0000169", "GOC:BHF", "GOC:mtg_apoptosis", "PMID:16087305" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097060", "lbl" : "synaptic membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.", + "xrefs" : [ "GOC:BHF", "PMID:20410104" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097084", "lbl" : "vascular associated smooth muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097152", "lbl" : "mesenchymal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.", + "xrefs" : [ "CL:0000134", "GOC:mtg_apoptosis", "GOC:yaf", "PMID:18231833" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097164", "lbl" : "ammonium ion metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving the ammonium ion.", + "xrefs" : [ "GOC:dhl", "GOC:tb", "PMID:14671018" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097190", "lbl" : "apoptotic signaling pathway", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.", + "xrefs" : [ "GOC:mtg_apoptosis" ] + }, + "comments" : [ "This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097194", "lbl" : "execution phase of apoptosis", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0097212", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.", + "xrefs" : [ "GOC:mtg_apoptosis", "PMID:21760595" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097212", "lbl" : "lysosomal membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.", + "xrefs" : [ "GOC:yaf", "PMID:20544854" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097237", + "lbl" : "cellular response to toxic substance", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.", + "xrefs" : [ "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097254", + "lbl" : "renal tubular secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.", + "xrefs" : [ "GOC:rph", "PMID:25287933", "Wikipedia:Renal_secretion#Secretion" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097272", + "lbl" : "ammonium homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of an internal steady state of ammonium.", + "xrefs" : [ "GOC:yaf", "PMID:12695560" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097275", + "lbl" : "intracellular ammonium homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell.", + "xrefs" : [ "GOC:yaf", "PMID:12695560" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097284", + "lbl" : "hepatocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a hepatocyte, the main structural component of the liver.", + "xrefs" : [ "CL:0000182", "GOC:jc", "GOC:mtg_apoptosis", "PMID:15856020" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097355", "lbl" : "protein localization to heterochromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097386", "lbl" : "glial cell projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A prolongation or process extending from a glial cell.", + "xrefs" : [ "GOC:mc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097402", "lbl" : "neuroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.", + "xrefs" : [ "CL:0000031", "GOC:jc", "PMID:15543145" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097427", "lbl" : "microtubule bundle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arrangement of closely apposed microtubules running parallel to each other.", + "xrefs" : [ "NIF_Subcellular:sao1872343973" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1872343973" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097435", "lbl" : "supramolecular fiber organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.", + "xrefs" : [ "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097473", "lbl" : "retinal rod cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina.", + "xrefs" : [ "CL:0000604", "GOC:jc", "PMID:17202487" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097474", "lbl" : "retinal cone cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina.", + "xrefs" : [ "CL:0000573", "GOC:jc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097475", "lbl" : "motor neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.", + "xrefs" : [ "CL:0000100", "GOC:yaf", "PMID:20711475" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097476", "lbl" : "spinal cord motor neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.", + "xrefs" : [ "CL:0011001", "GOC:yaf", "PMID:20711475" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097511", "lbl" : "dendritic cell dendrite", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.", + "xrefs" : [ "CL:0000451", "GOC:BHF", "GOC:cjm", "PMID:12200351" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097512", "lbl" : "cardiac myofibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac myofibril is a myofibril specific to cardiac muscle cells.", + "xrefs" : [ "GOC:cjm", "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097529", "lbl" : "myeloid leukocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a myeloid leukocyte within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:cvs", "PMID:22342843", "PMID:24157461" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097530", "lbl" : "granulocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a granulocyte within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:cvs", "PMID:24163421", "PMID:24193336" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097534", "lbl" : "lymphoid lineage cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage.", + "xrefs" : [ "GOC:pr", "PMID:22342843" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097576", "lbl" : "vacuole fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole.", + "xrefs" : [ "GOC:pr", "GOC:vw", "Wikipedia:Vacuole" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097708", "lbl" : "intracellular vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vesicle that is part of the intracellular region.", + "xrefs" : [ "GOC:vesicles" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097711", "lbl" : "ciliary basal body-plasma membrane docking", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.", + "xrefs" : [ "GOC:cilia", "PMID:13978319", "PMID:23348840", "PMID:23530209", "PMID:25686250", "PMID:26981235" ] + }, + "comments" : [ "Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097712", "lbl" : "vesicle targeting, trans-Golgi to periciliary membrane compartment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces.", + "xrefs" : [ "GOC:cilia", "PMID:20106869", "PMID:23351793", "PMID:24814148", "PMID:26485645" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097734", "lbl" : "extracellular exosome biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "PMID:19442504", "PMID:25392495" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098523", "lbl" : "neuromuscular junction of myotube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuromuscular junction in which the target muscle cell is a myotube.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098528", "lbl" : "skeletal muscle fiber differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098588", "lbl" : "bounding membrane of organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer that forms the outer-most layer of an organelle.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098590", "lbl" : "plasma membrane region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membrane that is a (regional) part of the plasma membrane.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098609", "lbl" : "cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The attachment of one cell to another cell via adhesion molecules.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098635", "lbl" : "protein complex involved in cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098636", "lbl" : "protein complex involved in cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098642", "lbl" : "network-forming collagen trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collagen trimer that forms networks.", + "xrefs" : [ "PMID:21421911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098643", "lbl" : "banded collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands).", + "xrefs" : [ "GOC:dos", "PMID:21421911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098644", "lbl" : "complex of collagen trimers", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A complex of collagen trimers such as a fibril or collagen network.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098645", "lbl" : "collagen network", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A supramolecular complex that consists of collagen triple helices associated to form a network.", + "xrefs" : [ "GOC:dos", "PMID:21421911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098651", "lbl" : "basement membrane collagen trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collagen timer that is part of a basement membrane.", + "xrefs" : [ "GOC:dos", "PMID:21421911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098657", "lbl" : "import into cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098722", "lbl" : "asymmetric stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity.", + "xrefs" : [ "GOC:dos", "PMID:18513950" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098723", "lbl" : "skeletal muscle myofibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myofibril of a skeletal muscle fiber.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098728", "lbl" : "germline stem cell asymmetric division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098751", "lbl" : "bone cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0098754", + "lbl" : "detoxification", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098773", "lbl" : "skin epidermis development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098793", "lbl" : "presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of a synapse that is part of the presynaptic cell.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098794", "lbl" : "postsynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of a synapse that is part of the post-synaptic cell.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098796", "lbl" : "membrane protein complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any protein complex that is part of a membrane.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098797", "lbl" : "plasma membrane protein complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any protein complex that is part of the plasma membrane.", + "xrefs" : [ "GOC:dos" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0098801", + "lbl" : "regulation of renal system process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098813", "lbl" : "nuclear chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098840", "lbl" : "protein transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein along a microtubule, mediated by motor proteins.", + "xrefs" : [ "PMID:25987607" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098852", "lbl" : "lytic vacuole membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098858", "lbl" : "actin-based cell projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell projection supported by an assembly of actin filaments, and which lacks microtubules.", + "xrefs" : [ "PMID:15661519" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098867", "lbl" : "intramembranous bone growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone.", + "xrefs" : [ "PMID:26399686" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098868", "lbl" : "bone growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of a bone that contributes to the shaping of that bone.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098871", "lbl" : "postsynaptic actin cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The actin cytoskeleton that is part of a postsynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098876", "lbl" : "vesicle-mediated transport to the plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098883", "lbl" : "synapse pruning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.", + "xrefs" : [ "GOC:dos", "PMID:12062020", "PMID:18083105", "PMID:22632716", "PMID:29844190" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098900", "lbl" : "regulation of action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:dos", "GOC:dph", "GOC:go_curators", "GOC:tb", "ISBN:978-0-07-139011-8" ] + }, + "comments" : [ "The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098901", "lbl" : "regulation of cardiac muscle cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:dos", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098904", "lbl" : "regulation of AV node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098906", "lbl" : "regulation of Purkinje myocyte action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098907", "lbl" : "regulation of SA node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098908", "lbl" : "regulation of neuronal action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098916", "lbl" : "anterograde trans-synaptic signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling from pre to post-synapse, across the synaptic cleft.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098917", "lbl" : "retrograde trans-synaptic signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling from post to pre-synapse, across the synaptic cleft.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098920", "lbl" : "retrograde trans-synaptic signaling by lipid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098926", "lbl" : "postsynaptic signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Signal transduction in which the initial step occurs in a postsynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098928", "lbl" : "presynaptic signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Signal transduction in which the initial step occurs in a presynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098974", "lbl" : "postsynaptic actin cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098975", "lbl" : "postsynapse of neuromuscular junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma.", + "xrefs" : [ "GOC:dos", "Wikipedia:Neuromuscular_junction&oldid=723623502" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098992", "lbl" : "neuronal dense core vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals.", + "xrefs" : [ "GOC:dos", "ISBN:978-0-07-181001-2", "Wikipedia:Neuropeptide&oldid=713905176" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099003", "lbl" : "vesicle-mediated transport in synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vesicle-mediated transport that occurs in a synapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099012", "lbl" : "neuronal dense core vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a neuronal dense core vesicle.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099014", "lbl" : "neuronal dense core vesicle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099054", "lbl" : "presynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a presynapse.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "GOC:dos", "PMID:24449494" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099068", "lbl" : "postsynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a postsynapse.", + "xrefs" : [ "GOC:bf", "GOC:dos", "GOCL:PARL" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099080", "lbl" : "supramolecular complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099081", "lbl" : "supramolecular polymer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A polymeric supramolecular structure.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099082", "lbl" : "retrograde trans-synaptic signaling by neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "GOC:dos", "PMID:19448629" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099083", "lbl" : "retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "GOC:dos", "PMID:19448629" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099098", "lbl" : "microtubule polymerization based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a cellular component as a result of microtubule polymerization.", + "xrefs" : [ "GOC:cjm", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099111", "lbl" : "microtubule-based transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.", + "xrefs" : [ "GOC:cjm", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099112", "lbl" : "microtubule polymerization based protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The transport of a protein driven by polymerization of a microtubule to which it is attached.", + "xrefs" : [ "GOC:dos", "GOC:vw", "PMID:11018050" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099118", "lbl" : "microtubule-based protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A microtubule-based process that results in the transport of proteins.", + "xrefs" : [ "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099140", "lbl" : "presynaptic actin cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099143", "lbl" : "presynaptic actin cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The actin cytoskeleton that is part of a presynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099156", "lbl" : "cell-cell signaling via exosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling in which the ligand is carried between cells by an exosome.", + "xrefs" : [ "GOC:dos", "PMID:19837038" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099157", "lbl" : "trans-synaptic signaling via exosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Transynaptic signaling in which the ligand is carried across the synapse by an exosome.", + "xrefs" : [ "GOC:dos", "PMID:19837038" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099170", "lbl" : "postsynaptic modulation of chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099171", "lbl" : "presynaptic modulation of chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099172", "lbl" : "presynapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099173", "lbl" : "postsynapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099174", "lbl" : "regulation of presynapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the physical form of a presynapse.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099175", "lbl" : "regulation of postsynapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the physical form of a postsynapse.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099177", "lbl" : "regulation of trans-synaptic signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of trans-synaptic signaling.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099187", "lbl" : "presynaptic cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099188", "lbl" : "postsynaptic cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099500", "lbl" : "vesicle fusion to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "ISBN:0071120009", "PMID:18618940" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099501", "lbl" : "exocytic vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding an exocytic vesicle.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099503", "lbl" : "secretory vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099512", "lbl" : "supramolecular fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099513", "lbl" : "polymeric cytoskeletal fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099515", "lbl" : "actin filament-based transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The transport of organelles or other particles from one location in the cell to another along actin filaments.", + "xrefs" : [ "GOC:dos", "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099518", "lbl" : "vesicle cytoskeletal trafficking", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins.", + "xrefs" : [ "GOC:ecd", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099531", "lbl" : "presynaptic process involved in chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099536", "lbl" : "synaptic signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling to, from or within a synapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099537", "lbl" : "trans-synaptic signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling in either direction across the synaptic cleft.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099538", "lbl" : "synaptic signaling via neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling to or from a synapse, mediated by a peptide.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099540", "lbl" : "trans-synaptic signaling by neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099541", "lbl" : "trans-synaptic signaling by lipid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid.", + "xrefs" : [ "GOC:dos" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0099546", + "lbl" : "protein catabolic process, modulating synaptic transmission", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.", + "xrefs" : [ "GOC:dos", "PMID:23083742" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099547", "lbl" : "regulation of translation at synapse, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating translation occurring at the synapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099550", "lbl" : "trans-synaptic signaling, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099551", "lbl" : "trans-synaptic signaling by neuropeptide, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099552", "lbl" : "trans-synaptic signaling by lipid, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse.", + "xrefs" : [ "GOC:dos", "PMID:21531987" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099568", "lbl" : "cytoplasmic region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099569", "lbl" : "presynaptic cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the cytoskeleton contained within the presynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099571", "lbl" : "postsynaptic cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the cytoskeleton contained within the postsynapse.", + "xrefs" : [ "GOC:dos", "PMID:19889835" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0099574", + "lbl" : "regulation of protein catabolic process at synapse, modulating synaptic transmission", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating protein degradation at the synapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0099575", + "lbl" : "regulation of protein catabolic process at presynapse, modulating synaptic transmission", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0099576", + "lbl" : "regulation of protein catabolic process at postsynapse, modulating synaptic transmission", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099577", "lbl" : "regulation of translation at presynapse, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099578", "lbl" : "regulation of translation at postsynapse, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099632", "lbl" : "protein transport within plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which protein is transported from one region of the plasma membrane to another.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099640", "lbl" : "axo-dendritic protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins along microtubules in neuron projections.", + "xrefs" : [ "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099643", "lbl" : "signal release from synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any signal release from a synapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099738", "lbl" : "cell cortex region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The complete extent of cell cortex that underlies some some region of the plasma membrane.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0100001", "lbl" : "regulation of skeletal muscle contraction by action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any action potential process that regulates skeletal muscle contraction.", + "xrefs" : [ "GOC:cjm", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0101023", "lbl" : "vascular endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:nc", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0101024", "lbl" : "mitotic nuclear membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis.", + "xrefs" : [ "GOC:vw", "PMID:15147872" ] + }, + "comments" : [ "This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0101025", "lbl" : "nuclear membrane biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a nuclear membrane is synthesized, aggregates, and bonds together.", + "xrefs" : [ "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0106027", "lbl" : "neuron projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:11585923" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0106214", "lbl" : "regulation of vesicle fusion with Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus.", + "xrefs" : [ "GOC:se", "PMID:26195667" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0106215", "lbl" : "negative regulation of vesicle fusion with Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus.", + "xrefs" : [ "GOC:se", "PMID:26195667" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0106216", "lbl" : "positive regulation of vesicle fusion with Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus.", + "xrefs" : [ "GOC:se", "PMID:26195667" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110011", "lbl" : "regulation of basement membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane.", + "xrefs" : [ "GOC:ha", "PMID:27404358" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110020", "lbl" : "regulation of actomyosin structure organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin.", + "xrefs" : [ "GOC:lf", "PMID:22790195" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110021", "lbl" : "cardiac muscle myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:26512644" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110022", "lbl" : "regulation of cardiac muscle myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:26512644" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110023", "lbl" : "negative regulation of cardiac muscle myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:26512644" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110024", "lbl" : "positive regulation of cardiac muscle myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:26512644" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110053", "lbl" : "regulation of actin filament organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of actin filament organization.", + "xrefs" : [ "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110057", "lbl" : "regulation of blood vessel endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:23072816" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110058", "lbl" : "positive regulation of blood vessel endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:23072816" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110059", "lbl" : "negative regulation of blood vessel endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:23072816" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110077", "lbl" : "vesicle-mediated intercellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane.", + "xrefs" : [ "GOC:sp", "PMID:29328915", "PMID:29328916" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110110", "lbl" : "positive regulation of animal organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis.", + "xrefs" : [ "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110111", "lbl" : "negative regulation of animal organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis.", + "xrefs" : [ "GOC:kmv" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0110112", + "lbl" : "regulation of lipid transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of lipid transporter activity.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:27365390" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0110113", + "lbl" : "positive regulation of lipid transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate, or extent of lipid transporter activity.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:27365390" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0110114", + "lbl" : "negative regulation of lipid transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate, or extent of lipid transporter activity.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:27365390" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110116", "lbl" : "regulation of compound eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation.", + "xrefs" : [ "GOC:ha", "PMID:16377567" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110117", "lbl" : "positive regulation of compound eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation.", + "xrefs" : [ "GOC:ha", "PMID:16377567" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110118", "lbl" : "negative regulation of compound eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation.", + "xrefs" : [ "GOC:ha", "PMID:16377567" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110122", "lbl" : "myotube cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse.", + "xrefs" : [ "GOC:ha", "PMID:29122742" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110123", "lbl" : "regulation of myotube cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myotube cell migration.", + "xrefs" : [ "GOC:ha", "PMID:29122742" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110124", "lbl" : "positive regulation of myotube cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration.", + "xrefs" : [ "GOC:ha", "PMID:29122742" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110125", "lbl" : "negative regulation of myotube cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration.", + "xrefs" : [ "GOC:ha", "PMID:29122742" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110165", "lbl" : "cellular anatomical entity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.", + "xrefs" : [ "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120025", "lbl" : "plasma membrane bounded cell projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120031", "lbl" : "plasma membrane bounded cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120032", "lbl" : "regulation of plasma membrane bounded cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120033", "lbl" : "negative regulation of plasma membrane bounded cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120034", "lbl" : "positive regulation of plasma membrane bounded cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120035", "lbl" : "regulation of plasma membrane bounded cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120036", "lbl" : "plasma membrane bounded cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120039", "lbl" : "plasma membrane bounded cell projection morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120111", "lbl" : "neuron projection cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection.", + "xrefs" : [ "GOC:ha" ] + } + } }, { - "id" : "http://purl.obolibrary.org/obo/GO_0120186", - "lbl" : "negative regulation of protein localization to chromatin", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/GO_0120158", + "lbl" : "positive regulation of collagen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0120178", + "lbl" : "steroid hormone biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.", + "xrefs" : [ "GOC:krc", "GOC:nln" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0120186", + "lbl" : "negative regulation of protein localization to chromatin", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin.", + "xrefs" : [ "PMID:20889714", "PMID:29899453" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120187", "lbl" : "positive regulation of protein localization to chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin.", + "xrefs" : [ "PMID:20889714", "PMID:29899453" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0120188", + "lbl" : "regulation of bile acid secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:22767443" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0120189", + "lbl" : "positive regulation of bile acid secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:22767443" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0120190", + "lbl" : "negative regulation of bile acid secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:22767443" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120222", "lbl" : "regulation of blastocyst development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of blastocyst development.", + "xrefs" : [ "GOC:krc", "PMID:29593216" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120229", "lbl" : "protein localization to motile cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a motile cilium.", + "xrefs" : [ "GOC:krc", "PMID:27486780" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120305", "lbl" : "regulation of pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120331", "lbl" : "endothelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of an endothelial tube.", + "xrefs" : [ "GOC:sl", "PMID:23239824" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140013", "lbl" : "meiotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the two nuclear divisions that occur as part of the meiotic cell cycle.", + "xrefs" : [ "PMID:9334324" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140014", "lbl" : "mitotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.", + "xrefs" : [ "ISBN:0198547684" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140029", "lbl" : "exocytic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular processes that contribute to exocytosis.", + "xrefs" : [ "Wikipedia:Exocytosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140039", "lbl" : "cell-cell adhesion in response to extracellular stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus.", + "xrefs" : [ "PMID:14996911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140056", "lbl" : "organelle localization by membrane tethering", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other.", + "xrefs" : [ "PMID:27875684" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140075", "lbl" : "regulation of lipoprotein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that controls lipoprotein transport.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:RPH", "PMID:26501192" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140076", "lbl" : "negative regulation of lipoprotein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:RPH", "PMID:26501192" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140077", "lbl" : "positive regulation of lipoprotein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of lipoprotein transport.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:RPH", "PMID:26501192" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140096", + "lbl" : "catalytic activity, acting on a protein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalytic activity that acts to modify a protein.", + "xrefs" : [ "GOC:molecular_function_refactoring", "GOC:pdt" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140097", + "lbl" : "catalytic activity, acting on DNA", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalytic activity that acts to modify DNA.", + "xrefs" : [ "GOC:molecular_function_refactoring", "GOC:pdt" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140098", + "lbl" : "catalytic activity, acting on RNA", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalytic activity that acts to modify RNA, driven by ATP hydrolysis.", + "xrefs" : [ "GOC:molecular_function_refactoring", "GOC:pdt" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140103", + "lbl" : "catalytic activity, acting on a glycoprotein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein.", + "xrefs" : [ "GOC:molecular_function_refactoring", "GOC:pdt" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140112", "lbl" : "extracellular vesicle biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.", + "xrefs" : [ "PMID:28736435" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140131", "lbl" : "positive regulation of lymphocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis.", + "xrefs" : [ "PMID:19255442" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140236", "lbl" : "translation at presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Translation that occurs at the presynapse.", + "xrefs" : [ "PMID:27321671" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140237", "lbl" : "translation at presynapse, modulating chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.", + "xrefs" : [ "PMID:27321671" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140238", "lbl" : "presynaptic endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.", + "xrefs" : [ "PMID:24719103" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140239", "lbl" : "postsynaptic endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.", + "xrefs" : [ "PMID:12839988" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140241", "lbl" : "translation at synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Translation that occurs at the synapse.", + "xrefs" : [ "PMID:23083742" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140242", "lbl" : "translation at postsynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Translation that occurs at the postsynapse.", + "xrefs" : [ "PMID:20427644" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140243", "lbl" : "regulation of translation at synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that regulates translation occurring at the synapse.", + "xrefs" : [ "PMID:20427644" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140244", "lbl" : "regulation of translation at presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that regulates translation occurring at the presynapse.", + "xrefs" : [ "PMID:20427644" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140245", "lbl" : "regulation of translation at postsynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that regulates translation occurring at the postsynapse.", + "xrefs" : [ "PMID:20427644" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140246", + "lbl" : "protein catabolic process at synapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse.", + "xrefs" : [ "PMID:17062563" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140247", + "lbl" : "protein catabolic process at presynapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse.", + "xrefs" : [ "PMID:27764673" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140249", + "lbl" : "protein catabolic process at postsynapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse.", + "xrefs" : [ "PMID:17062563" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140250", + "lbl" : "regulation protein catabolic process at synapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse.", + "xrefs" : [ "PMID:23083742" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140251", + "lbl" : "regulation protein catabolic process at presynapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.", + "xrefs" : [ "PMID:27764673" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140252", + "lbl" : "regulation protein catabolic process at postsynapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.", + "xrefs" : [ "PMID:17062563" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140253", "lbl" : "cell-cell fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.", + "xrefs" : [ "Wikipedia:Cell_fusion" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140318", + "lbl" : "protein transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Directly binding to a specific protein and delivering it to a specific cellular location.", + "xrefs" : [ "PMID:18706423" ] + }, + "comments" : [ "Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation." ], + "xrefs" : [ { + "val" : "Reactome:R-HSA-2248891" + }, { + "val" : "Reactome:R-HSA-9662747" + }, { + "val" : "Reactome:R-HSA-9662818" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140352", "lbl" : "export from cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140353", "lbl" : "lipid export from cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a lipid from a cell, into the extracellular region.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140354", "lbl" : "lipid import into cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140513", "lbl" : "nuclear protein-containing complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140572", "lbl" : "vacuole fission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The division of a vacuole within a cell to form two or more separate vacuoles.", + "xrefs" : [ "PMID:19643199" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140694", "lbl" : "non-membrane-bounded organelle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.", + "xrefs" : [ "PMID:28225081" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140734", + "lbl" : "ammonium excretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The elimination of ammonium ions from an excretory cell.", + "xrefs" : [ "PMID:25740900" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140962", + "lbl" : "multicellular organismal-level chemical homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150031", "lbl" : "regulation of protein localization to lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to lysosome.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:24305806" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150032", "lbl" : "positive regulation of protein localization to lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to lysosome.", + "xrefs" : [ "GOC:aruk", "GOC:bc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150033", "lbl" : "negative regulation of protein localization to lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:24305806" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150052", "lbl" : "regulation of postsynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:16394100", "PMID:16672654", "PMID:28185854" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150063", "lbl" : "visual system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "GOC:krc", "PMID:15004427", "PMID:20647017", "PMID:22632727" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150076", "lbl" : "neuroinflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:10981966", "PMID:11099416", "PMID:18164423" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150077", "lbl" : "regulation of neuroinflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuroinflammatory response.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:10981966", "PMID:11099416", "PMID:18164423" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150078", "lbl" : "positive regulation of neuroinflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response.", + "xrefs" : [ "GOC:aruk", "GOC:bc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150079", "lbl" : "negative regulation of neuroinflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:11099416", "PMID:18164423" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150098", "lbl" : "glial cell-neuron signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:14980203", "PMID:16144764", "PMID:16547515", "PMID:18685038", "PMID:27788368", "PMID:9459440" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150099", "lbl" : "neuron-glial cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:10195197", "PMID:10196584", "PMID:10377338", "PMID:10493741", "PMID:11356870", "PMID:11399439", "PMID:15252819", "PMID:27788368" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150102", "lbl" : "negative regulation of monocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation.", + "xrefs" : [ "GOC:aruk", "PMID:15597323" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150105", "lbl" : "protein localization to cell-cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:26706435" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150106", "lbl" : "regulation of protein localization to cell-cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:26706435" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150107", "lbl" : "positive regulation of protein localization to cell-cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:26706435" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150111", "lbl" : "regulation of transepithelial transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of transepithelial transport.", + "xrefs" : [ "GOC:aruk", "PMID:27593915" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150119", "lbl" : "negative regulation of protein localization to cell-cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction.", + "xrefs" : [ "GOC:aruk", "GOC:bc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150146", "lbl" : "cell junction disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a cell junction into its constituent components.", + "xrefs" : [ "GOC:aruk", "PMID:25490267" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150147", "lbl" : "cell-cell junction disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a cell-cell junction into its constituent components.", + "xrefs" : [ "GOC:aruk", "PMID:25490267" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0160038", "lbl" : "somatic sensory system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain.", + "xrefs" : [ "PMID:25832476", "PMID:31399790" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0160093", "lbl" : "chordate pharynx development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure.", + "xrefs" : [ "PMID:23020903" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0170055", + "lbl" : "lipid transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a lipid from one side of a membrane to the other.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900015", "lbl" : "regulation of cytokine production involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900016", "lbl" : "negative regulation of cytokine production involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900017", "lbl" : "positive regulation of cytokine production involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1900076", + "lbl" : "regulation of cellular response to insulin stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1900077", + "lbl" : "negative regulation of cellular response to insulin stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1900078", + "lbl" : "positive regulation of cellular response to insulin stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900115", "lbl" : "extracellular regulation of signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any regulation of signal transduction that takes place in the extracellular region.", + "xrefs" : [ "GOC:TermGenie", "GOC:signaling" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900116", "lbl" : "extracellular negative regulation of signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any negative regulation of signal transduction that takes place in extracellular region.", + "xrefs" : [ "GOC:TermGenie", "GOC:signaling" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900117", "lbl" : "regulation of execution phase of apoptosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of execution phase of apoptosis.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900118", "lbl" : "negative regulation of execution phase of apoptosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900119", "lbl" : "positive regulation of execution phase of apoptosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900125", "lbl" : "regulation of hyaluronan biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900126", "lbl" : "negative regulation of hyaluronan biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900127", "lbl" : "positive regulation of hyaluronan biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900150", "lbl" : "regulation of defense response to fungus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of defense response to fungus.", + "xrefs" : [ "GOC:TermGenie", "GOC:dhl", "PMID:22242006" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900180", "lbl" : "regulation of protein localization to nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to nucleus.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900181", "lbl" : "negative regulation of protein localization to nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900182", "lbl" : "positive regulation of protein localization to nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900193", "lbl" : "regulation of oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900194", "lbl" : "negative regulation of oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900195", "lbl" : "positive regulation of oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900366", "lbl" : "negative regulation of defense response to insect", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect.", + "xrefs" : [ "GOC:TermGenie", "PMID:22474183" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900367", "lbl" : "positive regulation of defense response to insect", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of defense response to insect.", + "xrefs" : [ "GOC:TermGenie", "PMID:22474183" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900424", "lbl" : "regulation of defense response to bacterium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of defense response to bacterium.", + "xrefs" : [ "GOC:TermGenie", "PMID:22346749" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900425", "lbl" : "negative regulation of defense response to bacterium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.", + "xrefs" : [ "GOC:TermGenie", "PMID:22346749" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900426", "lbl" : "positive regulation of defense response to bacterium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of defense response to bacterium.", + "xrefs" : [ "GOC:TermGenie", "PMID:22346749" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901142", + "lbl" : "insulin metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving insulin.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901143", + "lbl" : "insulin catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of insulin.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901148", "lbl" : "gene expression involved in extracellular matrix organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form.", + "xrefs" : [ "GOC:TermGenie", "GOC:pg", "PMID:18668558" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901160", "lbl" : "primary amino compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving primary amino compound.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901161", + "lbl" : "primary amino compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of primary amino compound.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901162", "lbl" : "primary amino compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of primary amino compound.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901163", "lbl" : "regulation of trophoblast cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of trophoblast cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901164", "lbl" : "negative regulation of trophoblast cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901165", "lbl" : "positive regulation of trophoblast cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901166", "lbl" : "neural crest cell migration involved in autonomic nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neural crest cell migration that is involved in autonomic nervous system development.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901190", "lbl" : "regulation of formation of translation initiation ternary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901191", "lbl" : "negative regulation of formation of translation initiation ternary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901192", "lbl" : "positive regulation of formation of translation initiation ternary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901201", "lbl" : "regulation of extracellular matrix assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of extracellular matrix assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901202", "lbl" : "negative regulation of extracellular matrix assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901203", "lbl" : "positive regulation of extracellular matrix assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901210", "lbl" : "regulation of cardiac chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac chamber formation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901211", "lbl" : "negative regulation of cardiac chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901212", "lbl" : "positive regulation of cardiac chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901219", "lbl" : "regulation of cardiac chamber morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901220", "lbl" : "negative regulation of cardiac chamber morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901221", "lbl" : "positive regulation of cardiac chamber morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901246", "lbl" : "regulation of lung ciliated cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901247", "lbl" : "negative regulation of lung ciliated cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901248", "lbl" : "positive regulation of lung ciliated cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901342", "lbl" : "regulation of vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vasculature development.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901343", "lbl" : "negative regulation of vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901509", "lbl" : "regulation of endothelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901532", "lbl" : "regulation of hematopoietic progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901533", "lbl" : "negative regulation of hematopoietic progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901534", "lbl" : "positive regulation of hematopoietic progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901550", "lbl" : "regulation of endothelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial cell development.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr", "PMID:19470579" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901551", "lbl" : "negative regulation of endothelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr", "PMID:19470579" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901552", "lbl" : "positive regulation of endothelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial cell development.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr", "PMID:19470579" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901564", "lbl" : "organonitrogen compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving organonitrogen compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901565", + "lbl" : "organonitrogen compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of organonitrogen compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901566", "lbl" : "organonitrogen compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of organonitrogen compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901608", "lbl" : "regulation of vesicle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901609", "lbl" : "negative regulation of vesicle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901610", "lbl" : "positive regulation of vesicle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901615", "lbl" : "organic hydroxy compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving organic hydroxy compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901616", + "lbl" : "organic hydroxy compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901617", "lbl" : "organic hydroxy compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of organic hydroxy compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901618", + "lbl" : "organic hydroxy compound transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of organic hydroxy compound from one side of a membrane to the other.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901623", "lbl" : "regulation of lymphocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901624", "lbl" : "negative regulation of lymphocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901652", "lbl" : "response to peptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901653", "lbl" : "cellular response to peptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901654", + "lbl" : "response to ketone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A response that results in a state of tolerance to ketone.", + "xrefs" : [ "GOC:mengo_curators", "PMID:23356676" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901655", + "lbl" : "cellular response to ketone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901692", "lbl" : "regulation of compound eye retinal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis", "PMID:12021768" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901693", "lbl" : "negative regulation of compound eye retinal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis", "PMID:12021768" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901694", "lbl" : "positive regulation of compound eye retinal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis", "PMID:12021768" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901698", "lbl" : "response to nitrogen compound", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901699", "lbl" : "cellular response to nitrogen compound", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901706", "lbl" : "mesenchymal cell differentiation involved in bone development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state.", + "xrefs" : [ "GOC:TermGenie", "GOC:hjd", "PMID:21571217" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901861", "lbl" : "regulation of muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf", "PMID:23150719" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901862", "lbl" : "negative regulation of muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf", "PMID:23150719" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901863", "lbl" : "positive regulation of muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf", "PMID:23150719" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901879", "lbl" : "regulation of protein depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein depolymerization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "PMID:12032137" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901880", "lbl" : "negative regulation of protein depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "PMID:12032137" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901881", "lbl" : "positive regulation of protein depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein depolymerization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "PMID:12032137" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901888", "lbl" : "regulation of cell junction assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell junction assembly.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901889", "lbl" : "negative regulation of cell junction assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901890", "lbl" : "positive regulation of cell junction assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell junction assembly.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901963", "lbl" : "regulation of cell proliferation involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_heart", "PMID:21419760" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901964", "lbl" : "positive regulation of cell proliferation involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_heart", "PMID:21419760" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902017", "lbl" : "regulation of cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cilium assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:dph", "PMID:17719545" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902018", "lbl" : "negative regulation of cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:dph", "PMID:17719545" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902019", "lbl" : "regulation of cilium-dependent cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902020", "lbl" : "negative regulation of cilium-dependent cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902033", "lbl" : "regulation of hematopoietic stem cell proliferation", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_1902034", - "lbl" : "negative regulation of hematopoietic stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902034", + "lbl" : "negative regulation of hematopoietic stem cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902035", "lbl" : "positive regulation of hematopoietic stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902036", "lbl" : "regulation of hematopoietic stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902037", "lbl" : "negative regulation of hematopoietic stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902038", "lbl" : "positive regulation of hematopoietic stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902105", "lbl" : "regulation of leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of leukocyte differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902106", "lbl" : "negative regulation of leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902107", "lbl" : "positive regulation of leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902115", "lbl" : "regulation of organelle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of organelle assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902116", "lbl" : "negative regulation of organelle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902117", "lbl" : "positive regulation of organelle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of organelle assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902217", "lbl" : "erythrocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in an erythrocyte.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_apoptosis", "GOC:rl", "PMID:14569084" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902250", "lbl" : "regulation of erythrocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_apoptosis", "GOC:rl", "PMID:14569084" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902251", "lbl" : "negative regulation of erythrocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_apoptosis", "GOC:rl", "PMID:14569084" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902252", "lbl" : "positive regulation of erythrocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_apoptosis", "GOC:rl", "PMID:14569084" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902256", "lbl" : "regulation of apoptotic process involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_apoptosis", "PMID:16839542" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902257", "lbl" : "negative regulation of apoptotic process involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_apoptosis", "PMID:16839542" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902258", "lbl" : "positive regulation of apoptotic process involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_apoptosis", "PMID:16839542" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902262", "lbl" : "apoptotic process involved in blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that is involved in blood vessel morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_apoptosis", "PMID:16163358" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902275", "lbl" : "regulation of chromatin organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of chromatin organization.", + "xrefs" : [ "GOC:TermGenie", "GOC:bf", "GOC:vw", "GO_REF:0000058", "PMID:18314879" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902337", "lbl" : "regulation of apoptotic process involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:sart", "PMID:12202035" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902338", "lbl" : "negative regulation of apoptotic process involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:sart", "PMID:12202035" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902339", "lbl" : "positive regulation of apoptotic process involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:sart", "PMID:12202035" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902340", "lbl" : "negative regulation of chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23219725" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902369", + "lbl" : "negative regulation of RNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:bf", "PMID:16640457" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902414", "lbl" : "protein localization to cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a cell junction.", + "xrefs" : [ "GOC:TermGenie", "PMID:18332111" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902463", "lbl" : "protein localization to cell leading edge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a cell leading edge.", + "xrefs" : [ "GOC:TermGenie", "GOC:lb", "PMID:21543326" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902473", "lbl" : "regulation of protein localization to synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to synapse.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "PMID:22588719" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902474", "lbl" : "positive regulation of protein localization to synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to synapse.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "PMID:22588719" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902488", + "lbl" : "cholangiocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a cholangiocyte.", + "xrefs" : [ "GOC:TermGenie", "PMID:22961800" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902489", + "lbl" : "hepatoblast apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a hepatoblast.", + "xrefs" : [ "GOC:TermGenie", "PMID:22412967" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902494", + "lbl" : "catalytic complex", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A protein complex which is capable of catalytic activity.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "PMID:8077207" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902495", + "lbl" : "transmembrane transporter complex", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "PMID:18024586" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902510", + "lbl" : "regulation of apoptotic DNA fragmentation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation.", + "xrefs" : [ "GOC:TermGenie", "GOC:hjd", "PMID:15572351", "PMID:15723341" ] + }, + "comments" : [ "DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341)." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902511", + "lbl" : "negative regulation of apoptotic DNA fragmentation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation.", + "xrefs" : [ "GOC:TermGenie", "GOC:hjd", "PMID:15572351" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902512", + "lbl" : "positive regulation of apoptotic DNA fragmentation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation.", + "xrefs" : [ "GOC:TermGenie", "GOC:hjd", "PMID:15572351" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902513", "lbl" : "regulation of organelle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of organelle transport along microtubule.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "PMID:21147087" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902531", "lbl" : "regulation of intracellular signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of intracellular signal transduction.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:signaling", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902532", "lbl" : "negative regulation of intracellular signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:signaling", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902533", "lbl" : "positive regulation of intracellular signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:dph", "GOC:signaling", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902570", "lbl" : "protein localization to nucleolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a nucleolus.", + "xrefs" : [ "GOC:TermGenie", "PMID:22809626" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902679", "lbl" : "negative regulation of RNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.", + "xrefs" : [ "GO:jl", "GOC:TermGenie", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902680", "lbl" : "positive regulation of RNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process.", + "xrefs" : [ "GO:jl", "GOC:TermGenie", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902692", "lbl" : "regulation of neuroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuroblast proliferation.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:21168496" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902738", "lbl" : "regulation of chondrocyte differentiation involved in endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:8662546" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902742", "lbl" : "apoptotic process involved in development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that is involved in anatomical structure development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis", "GOC:pg", "GO_REF:0000060" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902761", "lbl" : "positive regulation of chondrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chondrocyte development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16575901" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902809", "lbl" : "regulation of skeletal muscle fiber differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:17879321" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902810", "lbl" : "negative regulation of skeletal muscle fiber differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:17879321" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902811", "lbl" : "positive regulation of skeletal muscle fiber differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:17879321" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902816", "lbl" : "regulation of protein localization to microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to microtubule.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058", "PMID:23087209" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902817", "lbl" : "negative regulation of protein localization to microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058", "PMID:23087209" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902838", "lbl" : "regulation of nuclear migration along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23087209" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902839", "lbl" : "negative regulation of nuclear migration along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23087209" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902840", "lbl" : "positive regulation of nuclear migration along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23087209" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902850", "lbl" : "microtubule cytoskeleton organization involved in mitosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microtubule cytoskeleton organization that is involved in mitosis.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000060", "PMID:18799626" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902863", "lbl" : "regulation of embryonic camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902864", "lbl" : "negative regulation of embryonic camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902865", "lbl" : "positive regulation of embryonic camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902866", "lbl" : "regulation of retina development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of retina development in camera-type eye.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902867", "lbl" : "negative regulation of retina development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902868", "lbl" : "positive regulation of retina development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902875", "lbl" : "regulation of embryonic pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of embryonic pattern specification.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902876", "lbl" : "negative regulation of embryonic pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902877", "lbl" : "positive regulation of embryonic pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902903", "lbl" : "regulation of supramolecular fiber organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of supramolecular fiber organization.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23921388" ] + }, + "comments" : [ "HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902904", "lbl" : "negative regulation of supramolecular fiber organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23921388" ] + }, + "comments" : [ "HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902905", "lbl" : "positive regulation of supramolecular fiber organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23921388" ] + }, + "comments" : [ "HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902913", "lbl" : "positive regulation of neuroepithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16916506" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903008", "lbl" : "organelle disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of an organelle into its constituent components.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000079" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903010", "lbl" : "regulation of bone development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of bone development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:22510437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903011", "lbl" : "negative regulation of bone development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of bone development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:22510437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903012", "lbl" : "positive regulation of bone development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of bone development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:22510437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903018", "lbl" : "regulation of glycoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23544079" ] + }, + "comments" : [ "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903019", "lbl" : "negative regulation of glycoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23544079" ] + }, + "comments" : [ "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903020", "lbl" : "positive regulation of glycoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23544079" ] + }, + "comments" : [ "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903037", "lbl" : "regulation of leukocyte cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:21106532" ] + }, + "comments" : [ "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903038", "lbl" : "negative regulation of leukocyte cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:21106532" ] + }, + "comments" : [ "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903039", "lbl" : "positive regulation of leukocyte cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:21106532" ] + }, + "comments" : [ "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903045", "lbl" : "neural crest cell migration involved in sympathetic nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neural crest cell migration that is involved in sympathetic nervous system development.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000060", "PMID:19325129" ] + }, + "comments" : [ "Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903046", "lbl" : "meiotic cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is part of the meiotic cell cycle.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_cell_cycle", "GO_REF:0000060" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903047", "lbl" : "mitotic cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is part of the mitotic cell cycle.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_cell_cycle", "GO_REF:0000060" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903053", "lbl" : "regulation of extracellular matrix organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of extracellular matrix organization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:22357537" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903054", "lbl" : "negative regulation of extracellular matrix organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:22357537" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903055", "lbl" : "positive regulation of extracellular matrix organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:22357537" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903076", "lbl" : "regulation of protein localization to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:11602640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903077", "lbl" : "negative regulation of protein localization to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:11602640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903078", "lbl" : "positive regulation of protein localization to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:11602640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903115", "lbl" : "regulation of actin filament-based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of actin filament-based movement.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24798735" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903116", "lbl" : "positive regulation of actin filament-based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of actin filament-based movement.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24798735" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903119", "lbl" : "protein localization to actin cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:24798735" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903120", "lbl" : "protein localization to actin filament bundle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:24798735" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903131", "lbl" : "mononuclear cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell.", + "xrefs" : [ "CL:0000842", "GOC:TermGenie", "GO_REF:0000086", "PMID:24759906" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903224", "lbl" : "regulation of endodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endodermal cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23154389" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903225", "lbl" : "negative regulation of endodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23154389" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903226", "lbl" : "positive regulation of endodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23154389" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903251", "lbl" : "multi-ciliated epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:sp", "GO_REF:0000086", "PMID:22231168", "PMID:24934224" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903292", "lbl" : "protein localization to Golgi membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:11378902" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903335", "lbl" : "regulation of vacuolar transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vacuolar transport.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903336", "lbl" : "negative regulation of vacuolar transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903337", "lbl" : "positive regulation of vacuolar transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vacuolar transport.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903353", "lbl" : "regulation of nucleus organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of nucleus organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:16943282" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903358", "lbl" : "regulation of Golgi organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of Golgi organization.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:17562788" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903379", "lbl" : "regulation of mitotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:9490640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903380", "lbl" : "positive regulation of mitotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:9490640" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903412", + "lbl" : "response to bile acid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000071", "PMID:21757002" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903413", + "lbl" : "cellular response to bile acid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000071", "PMID:21757002" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903429", "lbl" : "regulation of cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell maturation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17459944" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903430", "lbl" : "negative regulation of cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17459944" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903431", "lbl" : "positive regulation of cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell maturation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17459944" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903441", "lbl" : "protein localization to ciliary membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000087", "PMID:22139371" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903510", + "lbl" : "mucopolysaccharide metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving mucopolysaccharide.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000068", "PMID:4236091" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903522", "lbl" : "regulation of blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:10659969" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903523", "lbl" : "negative regulation of blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:10659969" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903524", "lbl" : "positive regulation of blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:10659969" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903530", "lbl" : "regulation of secretion by cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of secretion by cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:pm", "GO_REF:0000058", "PMID:12130530" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903531", "lbl" : "negative regulation of secretion by cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:pm", "GO_REF:0000058", "PMID:12130530" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903532", "lbl" : "positive regulation of secretion by cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of secretion by cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:pm", "GO_REF:0000058", "PMID:12130530" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903537", "lbl" : "meiotic cell cycle process involved in oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any meiotic cell cycle process that is involved in oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GOC:jz", "GO_REF:0000060", "PMID:25212395" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903538", "lbl" : "regulation of meiotic cell cycle process involved in oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GOC:jz", "GO_REF:0000058", "PMID:25212395" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903541", "lbl" : "regulation of exosomal secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of exosomal secretion.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903542", "lbl" : "negative regulation of exosomal secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903543", "lbl" : "positive regulation of exosomal secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of exosomal secretion.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903551", "lbl" : "regulation of extracellular exosome assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903552", "lbl" : "negative regulation of extracellular exosome assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903553", "lbl" : "positive regulation of extracellular exosome assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903561", "lbl" : "extracellular vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vesicle that is part of the extracellular region.", + "xrefs" : [ "GOC:TermGenie", "GOC:pm", "GO_REF:0000064", "PMID:24769233" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903564", "lbl" : "regulation of protein localization to cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to cilium.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903565", "lbl" : "negative regulation of protein localization to cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903566", "lbl" : "positive regulation of protein localization to cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to cilium.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903567", "lbl" : "regulation of protein localization to ciliary membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903568", "lbl" : "negative regulation of protein localization to ciliary membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903569", "lbl" : "positive regulation of protein localization to ciliary membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903624", + "lbl" : "regulation of DNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of DNA catabolic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:2001740" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903625", + "lbl" : "negative regulation of DNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:2001740" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903626", + "lbl" : "positive regulation of DNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of DNA catabolic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:2001740" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903697", "lbl" : "negative regulation of microvillus assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:22797597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903698", "lbl" : "positive regulation of microvillus assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of microvillus assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:22797597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903701", "lbl" : "substantia propria of cornea development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000094", "PMID:12556382" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903702", "lbl" : "esophagus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000094", "ISBN:0-683-40008-8" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903706", "lbl" : "regulation of hemopoiesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hemopoiesis.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:20080761" ] + }, + "comments" : [ "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903707", "lbl" : "negative regulation of hemopoiesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:20080761" ] + }, + "comments" : [ "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903708", "lbl" : "positive regulation of hemopoiesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hemopoiesis.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:20080761" ] + }, + "comments" : [ "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903729", "lbl" : "regulation of plasma membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of plasma membrane organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24514900" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903778", "lbl" : "protein localization to vacuolar membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:25378562" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903779", "lbl" : "regulation of cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac conduction.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_cardiac_conduct_nov11", "GOC:rph", "GO_REF:0000058", "PMID:12967627" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903780", "lbl" : "negative regulation of cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_cardiac_conduct_nov11", "GOC:rph", "GO_REF:0000058", "PMID:12967627" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903781", "lbl" : "positive regulation of cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac conduction.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_cardiac_conduct_nov11", "GOC:rph", "GO_REF:0000058", "PMID:12967627" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903825", + "lbl" : "organic acid transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an organic acid is transported across a membrane.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000069" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903828", "lbl" : "negative regulation of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903829", "lbl" : "positive regulation of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a protein localization.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903831", "lbl" : "signal transduction involved in cellular response to ammonium ion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any signal transduction that is involved in cellular response to ammonium ion.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000060", "PMID:16297994" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903847", "lbl" : "regulation of aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of aorta morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22269326" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903848", "lbl" : "negative regulation of aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22269326" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903849", "lbl" : "positive regulation of aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22269326" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903867", "lbl" : "extraembryonic membrane development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000094", "ISBN:0073040584" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903903", "lbl" : "regulation of establishment of T cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of establishment of T cell polarity.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23575248" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903904", "lbl" : "negative regulation of establishment of T cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23575248" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903905", "lbl" : "positive regulation of establishment of T cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23575248" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903941", "lbl" : "negative regulation of respiratory gaseous exchange", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22819705" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903942", "lbl" : "positive regulation of respiratory gaseous exchange", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22819705" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903943", + "lbl" : "regulation of hepatocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:8649852" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903944", + "lbl" : "negative regulation of hepatocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:8649852" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903945", + "lbl" : "positive regulation of hepatocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:8649852" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903950", "lbl" : "negative regulation of AV node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_cardiac_conduct_nov11", "GOC:nc", "GO_REF:0000058", "PMID:25281747" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903951", "lbl" : "positive regulation of AV node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of AV node cell action potential.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_cardiac_conduct_nov11", "GOC:nc", "GO_REF:0000058", "PMID:25281747" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903975", "lbl" : "regulation of glial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of glial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:19100238" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903976", "lbl" : "negative regulation of glial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:19100238" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903977", "lbl" : "positive regulation of glial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of glial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:19100238" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904014", "lbl" : "response to serotonin", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_1904015", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:1505525" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904015", "lbl" : "cellular response to serotonin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:1505525" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904018", "lbl" : "positive regulation of vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vasculature development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:21472453" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904019", "lbl" : "epithelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in an epithelial cell.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000085", "PMID:19137015" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904026", "lbl" : "regulation of collagen fibril organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of collagen fibril organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25451920" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904027", "lbl" : "negative regulation of collagen fibril organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25451920" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904028", "lbl" : "positive regulation of collagen fibril organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of collagen fibril organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25451920" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904035", "lbl" : "regulation of epithelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19137015" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904036", "lbl" : "negative regulation of epithelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19137015" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904037", "lbl" : "positive regulation of epithelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19137015" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904054", + "lbl" : "regulation of cholangiocyte proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24434010" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904055", + "lbl" : "negative regulation of cholangiocyte proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24434010" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904056", + "lbl" : "positive regulation of cholangiocyte proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24434010" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904057", "lbl" : "negative regulation of sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17167094" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904058", "lbl" : "positive regulation of sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of sensory perception of pain.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17167094" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904073", "lbl" : "regulation of trophectodermal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24508636" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904074", "lbl" : "negative regulation of trophectodermal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24508636" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904075", "lbl" : "positive regulation of trophectodermal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24508636" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904106", "lbl" : "protein localization to microvillus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a microvillus.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "GO_REF:0000087", "PMID:25335890" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904145", "lbl" : "negative regulation of meiotic cell cycle process involved in oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22674394" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904146", "lbl" : "positive regulation of meiotic cell cycle process involved in oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22674394" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904170", "lbl" : "regulation of bleb assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of bleb assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:25651887" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904171", "lbl" : "negative regulation of bleb assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:25651887" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904172", "lbl" : "positive regulation of bleb assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of bleb assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:25651887" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904177", "lbl" : "regulation of adipose tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of adipose tissue development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23081848" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904178", "lbl" : "negative regulation of adipose tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23081848" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904179", "lbl" : "positive regulation of adipose tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of adipose tissue development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23081848" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904192", + "lbl" : "regulation of cholangiocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24498161" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904193", + "lbl" : "negative regulation of cholangiocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24498161" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904194", + "lbl" : "positive regulation of cholangiocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24498161" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904204", "lbl" : "regulation of skeletal muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23470307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904205", "lbl" : "negative regulation of skeletal muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23470307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904206", "lbl" : "positive regulation of skeletal muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23470307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904238", "lbl" : "pericyte cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000086", "PMID:23868830" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904251", + "lbl" : "regulation of bile acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of bile acid metabolic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904252", + "lbl" : "negative regulation of bile acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904253", + "lbl" : "positive regulation of bile acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904269", "lbl" : "cell leading edge cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cortex of the leading edge of a cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "GO_REF:0000064", "PMID:25843030" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904304", + "lbl" : "regulation of gastro-intestinal system smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10821044" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904305", + "lbl" : "negative regulation of gastro-intestinal system smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10821044" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904306", + "lbl" : "positive regulation of gastro-intestinal system smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10821044" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904341", + "lbl" : "regulation of colon smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24170253" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904342", + "lbl" : "negative regulation of colon smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24170253" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904343", + "lbl" : "positive regulation of colon smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24170253" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904344", "lbl" : "regulation of gastric mucosal blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10807413" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904345", "lbl" : "negative regulation of gastric mucosal blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10807413" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904346", "lbl" : "positive regulation of gastric mucosal blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10807413" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904347", + "lbl" : "regulation of small intestine smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:11991626" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904348", + "lbl" : "negative regulation of small intestine smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:11991626" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904349", + "lbl" : "positive regulation of small intestine smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:11991626" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904350", + "lbl" : "regulation of protein catabolic process in the vacuole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:25635054" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904351", + "lbl" : "negative regulation of protein catabolic process in the vacuole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:25635054" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904352", + "lbl" : "positive regulation of protein catabolic process in the vacuole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:25635054" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904375", "lbl" : "regulation of protein localization to cell periphery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to cell periphery.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18216290" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904376", "lbl" : "negative regulation of protein localization to cell periphery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18216290" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904377", "lbl" : "positive regulation of protein localization to cell periphery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18216290" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904396", "lbl" : "regulation of neuromuscular junction development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuromuscular junction development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:7722643" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904397", "lbl" : "negative regulation of neuromuscular junction development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:7722643" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904398", "lbl" : "positive regulation of neuromuscular junction development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:7722643" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904409", "lbl" : "regulation of secretory granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of secretory granule organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15039777" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904410", "lbl" : "negative regulation of secretory granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15039777" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904411", "lbl" : "positive regulation of secretory granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of secretory granule organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15039777" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904412", "lbl" : "regulation of cardiac ventricle development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac ventricle development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19590510" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904413", "lbl" : "negative regulation of cardiac ventricle development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19590510" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904414", "lbl" : "positive regulation of cardiac ventricle development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19590510" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904456", "lbl" : "negative regulation of neuronal action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25126967" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904457", "lbl" : "positive regulation of neuronal action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuronal action potential.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25126967" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904484", + "lbl" : "cloacal gland development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000094", "PMID:18805421" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904491", "lbl" : "protein localization to ciliary transition zone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "GO_REF:0000087", "PMID:21422230" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904587", "lbl" : "response to glycoprotein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:14597422" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904588", "lbl" : "cellular response to glycoprotein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:14597422" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904606", "lbl" : "fat cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a fat cell.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000085", "PMID:17024416" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904649", "lbl" : "regulation of fat cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of fat cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17024416" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904650", "lbl" : "negative regulation of fat cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17024416" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904651", "lbl" : "positive regulation of fat cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17024416" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904653", "lbl" : "regulation of lung alveolus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lung alveolus development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23962064" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904654", "lbl" : "negative regulation of lung alveolus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23962064" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904655", "lbl" : "positive regulation of lung alveolus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lung alveolus development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23962064" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904659", + "lbl" : "glucose transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which glucose is transported across a membrane.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000069", "PMID:9090050" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904675", "lbl" : "regulation of somatic stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of somatic stem cell division.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19409607" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904676", "lbl" : "negative regulation of somatic stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19409607" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904677", "lbl" : "positive regulation of somatic stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of somatic stem cell division.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19409607" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904680", + "lbl" : "peptide transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a peptide from one side of a membrane to the other.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000070" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-1500817" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904691", + "lbl" : "negative regulation of type B pancreatic cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24055447" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904692", + "lbl" : "positive regulation of type B pancreatic cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24055447" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904693", "lbl" : "midbrain morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process by which a midbrain is generated and organized.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000083", "PMID:21347250" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904697", + "lbl" : "regulation of acinar cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of acinar cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:9788538" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904698", + "lbl" : "negative regulation of acinar cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:9788538" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904699", + "lbl" : "positive regulation of acinar cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:9788538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904705", "lbl" : "regulation of vascular associated smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23246467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904706", "lbl" : "negative regulation of vascular associated smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23246467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904707", "lbl" : "positive regulation of vascular associated smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23246467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904738", "lbl" : "vascular associated smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a vascular associated smooth muscle cell from one site to another.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000091", "PMID:20693317" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904746", "lbl" : "negative regulation of apoptotic process involved in development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22801495" ] + }, + "comments" : [ "U4PR86 in PMID:22801495 inferred from mutant phenotype" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904747", "lbl" : "positive regulation of apoptotic process involved in development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22801495" ] + }, + "comments" : [ "U4PR86 in PMID:22801495 inferred from mutant phenotype" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904748", "lbl" : "regulation of apoptotic process involved in development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apoptotic process involved in development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22801495" ] + }, + "comments" : [ "Q10943 in PMID:22801495, inferred from mutant phenotype" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904749", "lbl" : "regulation of protein localization to nucleolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to nucleolus.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:24415760" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904750", "lbl" : "negative regulation of protein localization to nucleolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:24415760" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904751", "lbl" : "positive regulation of protein localization to nucleolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:24415760" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904752", "lbl" : "regulation of vascular associated smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:20693317" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904753", "lbl" : "negative regulation of vascular associated smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:20693317" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904754", "lbl" : "positive regulation of vascular associated smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:20693317" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904770", "lbl" : "intramembranous bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process by which an intramembranous bone is generated and organized.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000083", "PMID:26399686" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904776", "lbl" : "regulation of protein localization to cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to cell cortex.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17115027" ] + }, + "comments" : [ "An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904777", "lbl" : "negative regulation of protein localization to cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17115027" ] + }, + "comments" : [ "An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904778", "lbl" : "positive regulation of protein localization to cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17115027" ] + }, + "comments" : [ "An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904817", "lbl" : "serous membrane development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000094", "PMID:15840053" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904818", "lbl" : "visceral peritoneum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000094", "PMID:15840053" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904819", "lbl" : "parietal peritoneum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000094", "PMID:15840053" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904820", "lbl" : "peritoneum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000094", "PMID:15840053" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904829", "lbl" : "regulation of aortic smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22034194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904830", "lbl" : "negative regulation of aortic smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22034194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904831", "lbl" : "positive regulation of aortic smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22034194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904888", "lbl" : "cranial skeletal system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000094", "PMID:11262227" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904933", "lbl" : "regulation of cell proliferation in midbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:18953410", "PMID:24431302" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904934", "lbl" : "negative regulation of cell proliferation in midbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:18953410", "PMID:24431302" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904935", "lbl" : "positive regulation of cell proliferation in midbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:24431302" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904936", "lbl" : "interneuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of an interneuron from one site to another.", + "xrefs" : [ "GOC:TermGenie", "GOC:ah", "GO_REF:0000091", "PMID:18622031" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904937", "lbl" : "sensory neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a sensory neuron from one site to another.", + "xrefs" : [ "GOC:TermGenie", "GOC:ah", "GO_REF:0000091", "PMID:18622031" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904942", "lbl" : "regulation of cardiac ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac ventricle formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23575307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904943", "lbl" : "negative regulation of cardiac ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23575307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904944", "lbl" : "positive regulation of cardiac ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23575307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904950", "lbl" : "negative regulation of establishment of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22761445" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904951", "lbl" : "positive regulation of establishment of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of establishment of protein localization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22761445" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904987", "lbl" : "regulation of endothelial cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial cell activation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:24255059" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904988", "lbl" : "negative regulation of endothelial cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:24255059" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904989", "lbl" : "positive regulation of endothelial cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial cell activation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:24255059" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905039", + "lbl" : "carboxylic acid transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which carboxylic acid is transported across a membrane.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000069", "PMID:10869563" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905063", "lbl" : "regulation of vascular associated smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19088079" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905064", "lbl" : "negative regulation of vascular associated smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19088079" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905065", "lbl" : "positive regulation of vascular associated smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19088079" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905126", "lbl" : "regulation of axo-dendritic protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:20694152" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905127", "lbl" : "negative regulation of axo-dendritic protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:20694152" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905128", "lbl" : "positive regulation of axo-dendritic protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:20694152" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905139", "lbl" : "apical ectodermal ridge formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000081", "PMID:18359901", "PMID:9323126", "PMID:9596583" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905140", "lbl" : "regulation of apical ectodermal ridge formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18359901" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905141", "lbl" : "negative regulation of apical ectodermal ridge formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18359901" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905142", "lbl" : "positive regulation of apical ectodermal ridge formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18359901" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905146", + "lbl" : "lysosomal protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular protein catabolic process that takes place in a lysosome.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000062", "PMID:24334770" ] + }, + "comments" : [ "Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905147", "lbl" : "regulation of smooth muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:22161164" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905148", "lbl" : "negative regulation of smooth muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:22161164" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905149", "lbl" : "positive regulation of smooth muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:22161164" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905153", "lbl" : "regulation of membrane invagination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of membrane invagination.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:26589353" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905154", "lbl" : "negative regulation of membrane invagination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:26589353" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905155", "lbl" : "positive regulation of membrane invagination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of membrane invagination.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905165", + "lbl" : "regulation of lysosomal protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:23499937" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905166", + "lbl" : "negative regulation of lysosomal protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905167", + "lbl" : "positive regulation of lysosomal protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905207", "lbl" : "regulation of cardiocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiocyte differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23069713" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905208", "lbl" : "negative regulation of cardiocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23069713" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905209", "lbl" : "positive regulation of cardiocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23069713" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905213", "lbl" : "negative regulation of mitotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23219725" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905223", "lbl" : "epicardium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process by which an epicardium is generated and organized.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000083", "PMID:18718461" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905268", "lbl" : "negative regulation of chromatin organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr", "GOC:vw", "GO_REF:0000058", "PMID:654321" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905269", "lbl" : "positive regulation of chromatin organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chromatin organization.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr", "GOC:vw", "GO_REF:0000058", "PMID:654321" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905276", "lbl" : "regulation of epithelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial tube formation.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905277", "lbl" : "negative regulation of epithelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905278", "lbl" : "positive regulation of epithelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epithelial tube formation.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905288", "lbl" : "vascular associated smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a vascular associated smooth muscle cell.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000085", "PMID:26493107" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905292", "lbl" : "regulation of neural crest cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neural crest cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:15073157" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905293", "lbl" : "negative regulation of neural crest cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:15073157" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905294", "lbl" : "positive regulation of neural crest cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:15073157" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905298", + "lbl" : "regulation of intestinal epithelial cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23904268" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905299", + "lbl" : "negative regulation of intestinal epithelial cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23904268" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905300", + "lbl" : "positive regulation of intestinal epithelial cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23904268" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905304", "lbl" : "regulation of cardiac myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:16151019" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905305", "lbl" : "negative regulation of cardiac myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:16151019" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905306", "lbl" : "positive regulation of cardiac myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:16151019" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905310", "lbl" : "regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:17628518" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905311", "lbl" : "negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:17628518" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905312", "lbl" : "positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", - "type" : "CLASS" - }, { + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:17628518" ] + } + } + }, { "id" : "http://purl.obolibrary.org/obo/GO_1905315", "lbl" : "cell proliferation involved in endocardial cushion morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell proliferation that is involved in endocardial cushion morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000060", "PMID:20652948" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905319", "lbl" : "mesenchymal stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a mesenchymal stem cell from one site to another.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000091", "PMID:24924806", "PMID:25181476" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905320", "lbl" : "regulation of mesenchymal stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26846297" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905321", "lbl" : "negative regulation of mesenchymal stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26846297" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905322", "lbl" : "positive regulation of mesenchymal stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26846297" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905330", "lbl" : "regulation of morphogenesis of an epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905331", "lbl" : "negative regulation of morphogenesis of an epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905332", "lbl" : "positive regulation of morphogenesis of an epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905349", "lbl" : "ciliary transition zone assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GO_REF:0000079", "PMID:21725307", "PMID:23644468", "PMID:24448408", "PMID:26595381", "PMID:26982032" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905351", "lbl" : "pericyte cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a pericyte cell from one site to another.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000091", "PMID:26268439" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905383", "lbl" : "protein localization to presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a presynapse.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:24449494" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905384", "lbl" : "regulation of protein localization to presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to presynapse.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:24449494" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905385", "lbl" : "negative regulation of protein localization to presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:24449494" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905386", "lbl" : "positive regulation of protein localization to presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:24449494" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905432", "lbl" : "regulation of retrograde trans-synaptic signaling by neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:19448629" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905433", "lbl" : "negative regulation of retrograde trans-synaptic signaling by neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:19448629" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905434", "lbl" : "positive regulation of retrograde trans-synaptic signaling by neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:19448629" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905453", "lbl" : "regulation of myeloid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905454", "lbl" : "negative regulation of myeloid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905455", "lbl" : "positive regulation of myeloid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905456", "lbl" : "regulation of lymphoid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905457", "lbl" : "negative regulation of lymphoid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905458", "lbl" : "positive regulation of lymphoid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905459", "lbl" : "regulation of vascular associated smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:26493107" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905460", "lbl" : "negative regulation of vascular associated smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:26493107" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905461", "lbl" : "positive regulation of vascular associated smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:26493107" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905475", "lbl" : "regulation of protein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to membrane.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:26911690" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905476", "lbl" : "negative regulation of protein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:26911690" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905477", "lbl" : "positive regulation of protein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to membrane.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:26911690" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905483", "lbl" : "regulation of motor neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of motor neuron migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:16516839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905484", "lbl" : "negative regulation of motor neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:16516839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905485", "lbl" : "positive regulation of motor neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of motor neuron migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:16516839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905492", "lbl" : "positive regulation of branching morphogenesis of a nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:16516839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905503", "lbl" : "regulation of motile cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of motile cilium assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:25294941" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905504", "lbl" : "negative regulation of motile cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:25294941" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905505", "lbl" : "positive regulation of motile cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of motile cilium assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:25294941" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905516", "lbl" : "positive regulation of fertilization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of fertilization.", + "xrefs" : [ "GOC:TermGenie", "GOC:hbye", "GO_REF:0000058", "PMID:27564576" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905517", "lbl" : "macrophage migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a macrophage from one site to another.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000091", "PMID:25749876" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905521", "lbl" : "regulation of macrophage migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of macrophage migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25749876" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905522", "lbl" : "negative regulation of macrophage migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25749876" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905523", "lbl" : "positive regulation of macrophage migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of macrophage migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25749876" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905553", "lbl" : "regulation of blood vessel branching", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of blood vessel branching.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905554", "lbl" : "negative regulation of vessel branching", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905555", "lbl" : "positive regulation of blood vessel branching", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of blood vessel branching.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905557", "lbl" : "regulation of mitotic nuclear envelope disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18765790" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905558", "lbl" : "negative regulation of mitotic nuclear envelope disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18765790" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905559", "lbl" : "positive regulation of mitotic nuclear envelope disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18765790" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905562", "lbl" : "regulation of vascular endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905563", "lbl" : "negative regulation of vascular endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905564", "lbl" : "positive regulation of vascular endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905606", "lbl" : "regulation of presynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of presynapse assembly.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:25533483" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905607", "lbl" : "negative regulation of presynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:25533483" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905608", "lbl" : "positive regulation of presynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of presynapse assembly.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:25533483" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905627", "lbl" : "regulation of serotonin biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:25642596" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905628", "lbl" : "negative regulation of serotonin biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:25642596" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905629", "lbl" : "positive regulation of serotonin biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:25642596" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905632", "lbl" : "protein localization to euchromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within an euchromatin.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:20889714" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905633", "lbl" : "establishment of protein localization to euchromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location in an euchromatin.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:20889714" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905634", "lbl" : "regulation of protein localization to chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to chromatin.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:20889714" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905651", "lbl" : "regulation of artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of artery morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:27389411" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905652", "lbl" : "negative regulation of artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:27389411" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905653", "lbl" : "positive regulation of artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of artery morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:27389411" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905671", "lbl" : "regulation of lysosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lysosome organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25561470" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905672", "lbl" : "negative regulation of lysosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25561470" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905673", "lbl" : "positive regulation of lysosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lysosome organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25561470" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905690", "lbl" : "nucleus disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a nucleus into its constituent components.", + "xrefs" : [ "GOC:TermGenie", "GOC:autophagy", "GOC:pr", "GO_REF:0000079" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905720", "lbl" : "cytoplasmic microtubule bundle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microtubule bundle that is part of a cytoplasm.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000064", "PMID:11007487", "PMID:26124291" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905755", "lbl" : "protein localization to cytoplasmic microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:15177031" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905770", "lbl" : "regulation of mesodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23765923" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905771", "lbl" : "negative regulation of mesodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23765923" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905772", "lbl" : "positive regulation of mesodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23765923" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905806", "lbl" : "regulation of synapse pruning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of synapse pruning.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27779093" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905807", "lbl" : "negative regulation of synapse pruning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27779093" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905808", "lbl" : "positive regulation of synapse pruning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of synapse pruning.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27779093" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905809", "lbl" : "negative regulation of synapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27779093" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905821", "lbl" : "positive regulation of chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chromosome condensation.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:17268547" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905833", "lbl" : "negative regulation of microtubule nucleation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27689799" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905871", "lbl" : "regulation of protein localization to cell leading edge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26324884" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905872", "lbl" : "negative regulation of protein localization to cell leading edge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26324884" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905873", "lbl" : "positive regulation of protein localization to cell leading edge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26324884" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905879", "lbl" : "regulation of oogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of oogenesis.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26434723" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905880", "lbl" : "negative regulation of oogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26434723" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905881", "lbl" : "positive regulation of oogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of oogenesis.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26434723" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905899", "lbl" : "regulation of smooth muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:14709716" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905900", "lbl" : "negative regulation of smooth muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:14709716" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905901", "lbl" : "positive regulation of smooth muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:14709716" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905902", "lbl" : "regulation of mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesoderm formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23939491" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905903", "lbl" : "negative regulation of mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23939491" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905904", "lbl" : "positive regulation of mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesoderm formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23939491" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905936", "lbl" : "regulation of germ cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of germ cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905937", "lbl" : "negative regulation of germ cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905938", "lbl" : "positive regulation of germ cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of germ cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905939", "lbl" : "regulation of gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gonad development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905940", "lbl" : "negative regulation of gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905941", "lbl" : "positive regulation of gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gonad development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905952", "lbl" : "regulation of lipid localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lipid localization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17564681" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905953", "lbl" : "negative regulation of lipid localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17564681" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905954", "lbl" : "positive regulation of lipid localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lipid localization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17564681" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905955", "lbl" : "negative regulation of endothelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:25961718" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905956", "lbl" : "positive regulation of endothelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:25961718" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990009", "lbl" : "retinal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a retinal cell.", + "xrefs" : [ "GOC:mtg_apoptosis", "PMID:15558487", "PMID:24664675" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990010", "lbl" : "compound eye retinal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a compound eye retinal cell.", + "xrefs" : [ "GOC:mtg_apoptosis", "PMID:12021768" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990182", "lbl" : "exosomal secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.", + "xrefs" : [ "GOC:hjd", "PMID:10572093", "PMID:12154376", "PMID:16773132", "PMID:18617898" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990280", "lbl" : "RNA localization to chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin.", + "xrefs" : [ "GOC:dos", "GOC:mah", "PMID:22582262" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990351", + "lbl" : "transporter complex", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells.", + "xrefs" : [ "GOC:bhm", "PMID:15449578" ] + }, + "comments" : [ "An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990502", "lbl" : "dense core granule maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.", + "xrefs" : [ "GOC:kmv", "PMID:22654674" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990705", + "lbl" : "cholangiocyte proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water.", + "xrefs" : [ "PMID:24434010" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990748", + "lbl" : "cellular detoxification", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.", + "xrefs" : [ "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990765", + "lbl" : "colon smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum.", + "xrefs" : [ "PMID:24170253" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990768", "lbl" : "gastric mucosal blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products.", + "xrefs" : [ "PMID:10807413" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990770", + "lbl" : "small intestine smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine.", + "xrefs" : [ "PMID:11991626" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990778", "lbl" : "protein localization to cell periphery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, the cell periphery.", + "xrefs" : [ "PMID:18216290" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990849", "lbl" : "vacuolar localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "PMID:26283797" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990863", + "lbl" : "acinar cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus).", + "xrefs" : [ "PMID:9788538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990874", "lbl" : "vascular associated smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.", + "xrefs" : [ "PMID:23246467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990904", "lbl" : "ribonucleoprotein complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macromolecular complex that contains both RNA and protein molecules.", + "xrefs" : [ "GOC:krc", "GOC:vesicles" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Ribonucleoprotein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990917", "lbl" : "ooplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cytoplasm of an ovum.", + "xrefs" : [ "PMID:19022436" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000026", "lbl" : "regulation of multicellular organismal development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of multicellular organismal development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000027", "lbl" : "regulation of animal organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of animal organ morphogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000035", "lbl" : "regulation of stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of stem cell division.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000068", "lbl" : "regulation of defense response to insect", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of defense response to insect.", + "xrefs" : [ "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000074", + "lbl" : "regulation of type B pancreatic cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of pancreatic B cell development.", + "xrefs" : [ "GOC:obol", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000077", + "lbl" : "negative regulation of type B pancreatic cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development.", + "xrefs" : [ "GOC:obol", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000078", + "lbl" : "positive regulation of type B pancreatic cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development.", + "xrefs" : [ "GOC:obol", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000106", "lbl" : "regulation of leukocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000107", "lbl" : "negative regulation of leukocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000108", "lbl" : "positive regulation of leukocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000109", "lbl" : "regulation of macrophage apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of macrophage apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000110", "lbl" : "negative regulation of macrophage apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000111", "lbl" : "positive regulation of macrophage apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000114", "lbl" : "regulation of establishment of cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of establishment of cell polarity.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000136", "lbl" : "regulation of cell proliferation involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000137", "lbl" : "negative regulation of cell proliferation involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000138", "lbl" : "positive regulation of cell proliferation involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000145", "lbl" : "regulation of cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell motility.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000146", "lbl" : "negative regulation of cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000147", "lbl" : "positive regulation of cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell motility.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000155", "lbl" : "positive regulation of cilium-dependent cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility.", + "xrefs" : [ "GOC:cilia", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000172", "lbl" : "regulation of branching morphogenesis of a nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000173", "lbl" : "negative regulation of branching morphogenesis of a nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000174", "lbl" : "regulation of pro-T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of pro-T cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000175", "lbl" : "negative regulation of pro-T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000176", "lbl" : "positive regulation of pro-T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000177", "lbl" : "regulation of neural precursor cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000178", "lbl" : "negative regulation of neural precursor cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000179", "lbl" : "positive regulation of neural precursor cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000181", "lbl" : "negative regulation of blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000194", "lbl" : "regulation of female gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of female gonad development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000195", "lbl" : "negative regulation of female gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000196", "lbl" : "positive regulation of female gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of female gonad development.", + "xrefs" : [ "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000226", + "lbl" : "regulation of pancreatic A cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000227", + "lbl" : "negative regulation of pancreatic A cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000228", + "lbl" : "positive regulation of pancreatic A cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000241", "lbl" : "regulation of reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of reproductive process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000242", "lbl" : "negative regulation of reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000243", "lbl" : "positive regulation of reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of reproductive process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000248", "lbl" : "negative regulation of establishment or maintenance of neuroblast polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000269", "lbl" : "regulation of fibroblast apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000270", "lbl" : "negative regulation of fibroblast apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000271", "lbl" : "positive regulation of fibroblast apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000278", "lbl" : "regulation of DNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of DNA biosynthetic process.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000279", "lbl" : "negative regulation of DNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000287", "lbl" : "positive regulation of myotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myotome development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000288", "lbl" : "positive regulation of myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myoblast proliferation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000290", "lbl" : "regulation of myotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myotome development.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000291", "lbl" : "regulation of myoblast proliferation", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000351", - "lbl" : "regulation of endothelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myoblast proliferation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000352", - "lbl" : "negative regulation of endothelial cell apoptotic process", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/GO_2000292", + "lbl" : "regulation of defecation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of defecation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000353", - "lbl" : "positive regulation of endothelial cell apoptotic process", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/GO_2000293", + "lbl" : "negative regulation of defecation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of defecation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000374", + "id" : "http://purl.obolibrary.org/obo/GO_2000294", + "lbl" : "positive regulation of defecation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of defecation.", + "xrefs" : [ "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000351", + "lbl" : "regulation of endothelial cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000352", + "lbl" : "negative regulation of endothelial cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000353", + "lbl" : "positive regulation of endothelial cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000374", "lbl" : "regulation of oxygen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of oxygen metabolic process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000375", "lbl" : "negative regulation of oxygen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000376", "lbl" : "positive regulation of oxygen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000380", "lbl" : "regulation of mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000381", "lbl" : "negative regulation of mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000382", "lbl" : "positive regulation of mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000383", "lbl" : "regulation of ectoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of ectoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000384", "lbl" : "negative regulation of ectoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000385", "lbl" : "positive regulation of ectoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of ectoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000401", "lbl" : "regulation of lymphocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphocyte migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000402", "lbl" : "negative regulation of lymphocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000403", "lbl" : "positive regulation of lymphocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphocyte migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000404", "lbl" : "regulation of T cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of T cell migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000405", "lbl" : "negative regulation of T cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000406", "lbl" : "positive regulation of T cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of T cell migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000471", "lbl" : "regulation of hematopoietic stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000472", "lbl" : "negative regulation of hematopoietic stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000473", "lbl" : "positive regulation of hematopoietic stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000495", "lbl" : "regulation of cell proliferation involved in compound eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000496", "lbl" : "negative regulation of cell proliferation involved in compound eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000497", "lbl" : "positive regulation of cell proliferation involved in compound eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000508", "lbl" : "regulation of dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000509", "lbl" : "negative regulation of dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000510", "lbl" : "positive regulation of dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000527", "lbl" : "regulation of myeloid dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000528", "lbl" : "negative regulation of myeloid dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000529", "lbl" : "positive regulation of myeloid dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000542", "lbl" : "negative regulation of gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000543", "lbl" : "positive regulation of gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gastrulation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000547", "lbl" : "regulation of dendritic cell dendrite assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000548", "lbl" : "negative regulation of dendritic cell dendrite assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000549", "lbl" : "positive regulation of dendritic cell dendrite assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000573", "lbl" : "positive regulation of DNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000647", "lbl" : "negative regulation of stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000648", "lbl" : "positive regulation of stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of stem cell proliferation.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000668", "lbl" : "regulation of dendritic cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000669", "lbl" : "negative regulation of dendritic cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000670", "lbl" : "positive regulation of dendritic cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000671", "lbl" : "regulation of motor neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000672", "lbl" : "negative regulation of motor neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000673", "lbl" : "positive regulation of motor neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000674", + "lbl" : "regulation of type B pancreatic cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000675", + "lbl" : "negative regulation of type B pancreatic cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000676", + "lbl" : "positive regulation of type B pancreatic cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000690", "lbl" : "regulation of cardiac muscle cell myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000691", "lbl" : "negative regulation of cardiac muscle cell myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000700", "lbl" : "positive regulation of cardiac muscle cell myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000725", "lbl" : "regulation of cardiac muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000726", "lbl" : "negative regulation of cardiac muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000727", "lbl" : "positive regulation of cardiac muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000736", "lbl" : "regulation of stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of stem cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000737", "lbl" : "negative regulation of stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000738", "lbl" : "positive regulation of stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of stem cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000790", "lbl" : "regulation of mesenchymal cell proliferation involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.", + "xrefs" : [ "PMID:21513708" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000791", "lbl" : "negative regulation of mesenchymal cell proliferation involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.", + "xrefs" : [ "PMID:21513708" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000792", "lbl" : "positive regulation of mesenchymal cell proliferation involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.", + "xrefs" : [ "PMID:21513708" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000794", "lbl" : "regulation of epithelial cell proliferation involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.", + "xrefs" : [ "PMID:21513708" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000795", "lbl" : "negative regulation of epithelial cell proliferation involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.", + "xrefs" : [ "PMID:21513708" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000818", "lbl" : "negative regulation of myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000826", "lbl" : "regulation of heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of heart morphogenesis.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000831", "lbl" : "regulation of steroid hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of steroid hormone secretion.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000832", "lbl" : "negative regulation of steroid hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000833", "lbl" : "positive regulation of steroid hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000834", "lbl" : "regulation of androgen secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of androgen secretion.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000835", "lbl" : "negative regulation of androgen secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000836", "lbl" : "positive regulation of androgen secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of androgen secretion.", + "xrefs" : [ "GOC:sl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2001012", + "lbl" : "mesenchymal cell differentiation involved in renal system development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state.", + "xrefs" : [ "GOC:mtg_kidney_jan10", "GOC:obol", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001014", "lbl" : "regulation of skeletal muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001015", "lbl" : "negative regulation of skeletal muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001016", "lbl" : "positive regulation of skeletal muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001026", "lbl" : "regulation of endothelial cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001027", "lbl" : "negative regulation of endothelial cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001028", "lbl" : "positive regulation of endothelial cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001053", "lbl" : "regulation of mesenchymal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001054", "lbl" : "negative regulation of mesenchymal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001055", "lbl" : "positive regulation of mesenchymal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001141", "lbl" : "regulation of RNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of RNA biosynthetic process.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001198", "lbl" : "regulation of dendritic cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of dendritic cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001199", "lbl" : "negative regulation of dendritic cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001200", "lbl" : "positive regulation of dendritic cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001204", "lbl" : "regulation of osteoclast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of osteoclast development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001205", "lbl" : "negative regulation of osteoclast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001206", "lbl" : "positive regulation of osteoclast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of osteoclast development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001212", "lbl" : "regulation of vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vasculogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001213", "lbl" : "negative regulation of vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001214", "lbl" : "positive regulation of vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vasculogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001222", "lbl" : "regulation of neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuron migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001223", "lbl" : "negative regulation of neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001224", "lbl" : "positive regulation of neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuron migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001233", "lbl" : "regulation of apoptotic signaling pathway", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.", + "xrefs" : [ "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001234", "lbl" : "negative regulation of apoptotic signaling pathway", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.", + "xrefs" : [ "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001235", "lbl" : "positive regulation of apoptotic signaling pathway", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.", + "xrefs" : [ "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001251", "lbl" : "negative regulation of chromosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001252", "lbl" : "positive regulation of chromosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chromosome organization.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/NBO_0000073", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1", "lbl" : "root", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:30365038" + }, { + "val" : "PMID:32761142" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_117570", "lbl" : "Teleostomi", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_117571", "lbl" : "Euteleostomi", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1206794", "lbl" : "Ecdysozoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_131209", "lbl" : "Zygnemophyceae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_131221", "lbl" : "Streptophytina", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_131567", "lbl" : "cellular organisms", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1329799", "lbl" : "Archelosauria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:22839753" + }, { + "val" : "PMID:25450099" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1338369", "lbl" : "Dipnotetrapodomorpha", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_142796", "lbl" : "Eumycetozoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11062127" + }, { + "val" : "PMID:9342353" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1437010", + "lbl" : "Boreoeutheria", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11743200" + }, { + "val" : "PMID:11791233" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1437180", "lbl" : "Acrogymnospermae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1445966", "lbl" : "Gnetidae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_147537", "lbl" : "Saccharomycotina", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_147554", "lbl" : "Schizosaccharomycetes", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_186623", "lbl" : "Actinopteri", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_197562", "lbl" : "Pancrustacea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:10874751" + }, { + "val" : "PMID:11557979" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_197563", "lbl" : "Mandibulata", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11557979" + }, { + "val" : "PMID:9727836" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2", "lbl" : "Bacteria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:11" + }, { + "val" : "PMID:10425795" + }, { + "val" : "PMID:10425796" + }, { + "val" : "PMID:10425797" + }, { + "val" : "PMID:10490293" + }, { + "val" : "PMID:10843050" + }, { + "val" : "PMID:10939651" + }, { + "val" : "PMID:10939673" + }, { + "val" : "PMID:10939677" + }, { + "val" : "PMID:11211268" + }, { + "val" : "PMID:11321083" + }, { + "val" : "PMID:11321113" + }, { + "val" : "PMID:11411719" + }, { + "val" : "PMID:11540071" + }, { + "val" : "PMID:11542017" + }, { + "val" : "PMID:11542087" + }, { + "val" : "PMID:11760965" + }, { + "val" : "PMID:12054223" + }, { + "val" : "PMID:2112744" + }, { + "val" : "PMID:270744" + }, { + "val" : "PMID:32628106" + }, { + "val" : "PMID:36748408" + }, { + "val" : "PMID:7520741" + }, { + "val" : "PMID:8123559" + }, { + "val" : "PMID:8186100" + }, { + "val" : "PMID:8590690" + }, { + "val" : "PMID:9103655" + }, { + "val" : "PMID:9336922" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2058185", "lbl" : "Dictyosteliaceae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:29367151" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2058949", "lbl" : "Dictyosteliales", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:29367151" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_207598", + "lbl" : "Homininae", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2157", "lbl" : "Archaea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:11" + }, { + "val" : "PMID:10425795" + }, { + "val" : "PMID:10425796" + }, { + "val" : "PMID:10425797" + }, { + "val" : "PMID:10490293" + }, { + "val" : "PMID:10843050" + }, { + "val" : "PMID:10939651" + }, { + "val" : "PMID:10939673" + }, { + "val" : "PMID:10939677" + }, { + "val" : "PMID:11211268" + }, { + "val" : "PMID:11321083" + }, { + "val" : "PMID:11321113" + }, { + "val" : "PMID:11411719" + }, { + "val" : "PMID:11540071" + }, { + "val" : "PMID:11541975" + }, { + "val" : "PMID:11542064" + }, { + "val" : "PMID:11542149" + }, { + "val" : "PMID:11760965" + }, { + "val" : "PMID:12054223" + }, { + "val" : "PMID:2112744" + }, { + "val" : "PMID:25527841" + }, { + "val" : "PMID:270744" + }, { + "val" : "PMID:32628106" + }, { + "val" : "PMID:36748408" + }, { + "val" : "PMID:8123559" + }, { + "val" : "PMID:8590690" + }, { + "val" : "PMID:9103655" + }, { + "val" : "PMID:9336922" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2605435", "lbl" : "Evosea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2611352", "lbl" : "Discoba", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2684882", "lbl" : "Zygnematophycidae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2698737", "lbl" : "Sar", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2759", "lbl" : "Eukaryota", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:23020233" + }, { + "val" : "PMID:30257078" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_314146", + "lbl" : "Euarchontoglires", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11214319" + }, { + "val" : "PMID:12082125" + }, { + "val" : "PMID:12878460" + }, { + "val" : "PMID:15522813" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_314293", + "lbl" : "Simiiformes", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_314295", + "lbl" : "Hominoidea", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3176", "lbl" : "Zygnematales", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3193", "lbl" : "Embryophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_32443", "lbl" : "Teleostei", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_32523", "lbl" : "Tetrapoda", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_32524", "lbl" : "Amniota", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_32525", "lbl" : "Theria ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_32561", "lbl" : "Sauria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33083", "lbl" : "Dictyostelia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11062127" + }, { + "val" : "PMID:29367151" + }, { + "val" : "PMID:9342353" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33090", "lbl" : "Viridiplantae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:16248873" + }, { + "val" : "PMID:30257078" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3312", "lbl" : "Coniferophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33154", "lbl" : "Opisthokonta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33208", "lbl" : "Metazoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33213", "lbl" : "Bilateria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33317", "lbl" : "Protostomia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33511", "lbl" : "Deuterostomia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33630", "lbl" : "Alveolata", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33682", "lbl" : "Euglenozoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3372", "lbl" : "Gnetopsida", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3378", "lbl" : "Gnetales", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3398", "lbl" : "Magnoliopsida", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:25249442" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_34346", "lbl" : "Schizosaccharomycetales", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_35493", "lbl" : "Streptophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_376913", + "lbl" : "Haplorrhini", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_38254", "lbl" : "Glaucocystophyceae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_40674", "lbl" : "Mammalia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_41665", "lbl" : "Neopterygii", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_436486", "lbl" : "Dinosauria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_436489", "lbl" : "Saurischia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_436491", "lbl" : "Theropoda", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_436492", "lbl" : "Coelurosauria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_451864", "lbl" : "Dikarya", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:15689432" + }, { + "val" : "PMID:16151185" + }, { + "val" : "PMID:17010206" + }, { + "val" : "PMID:17051209" + }, { + "val" : "PMID:17572334" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_451866", "lbl" : "Taphrinomycotina", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4751", "lbl" : "Fungi", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11062127" + }, { + "val" : "PMID:12684019" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4890", "lbl" : "Ascomycota", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:17572334" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4891", "lbl" : "Saccharomycetes", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4892", "lbl" : "Saccharomycetales", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4893", "lbl" : "Saccharomycetaceae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4894", "lbl" : "Schizosaccharomycetaceae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4895", "lbl" : "Schizosaccharomyces", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4896", "lbl" : "Schizosaccharomyces pombe", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4930", "lbl" : "Saccharomyces", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4932", "lbl" : "Saccharomyces cerevisiae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_50557", "lbl" : "Insecta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_554915", "lbl" : "Amoebozoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:23020233" + }, { + "val" : "PMID:30257078" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_5782", "lbl" : "Dictyostelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:29367151" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_58023", "lbl" : "Tracheophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_58024", "lbl" : "Spermatophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_6072", "lbl" : "Eumetazoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_6656", "lbl" : "Arthropoda", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_6960", "lbl" : "Hexapoda", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_716545", "lbl" : "saccharomyceta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_7711", "lbl" : "Chordata", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_7742", "lbl" : "Vertebrata ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_7776", "lbl" : "Gnathostomata ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_78536", "lbl" : "Euphyllophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_7898", "lbl" : "Actinopterygii", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_8287", "lbl" : "Sarcopterygii", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_8457", "lbl" : "Sauropsida", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_8492", "lbl" : "Archosauria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_8782", "lbl" : "Aves", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_88770", "lbl" : "Panarthropoda", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_89593", "lbl" : "Craniata ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9347", + "lbl" : "Eutheria", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9443", + "lbl" : "Primates", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9526", + "lbl" : "Catarrhini", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9604", + "lbl" : "Hominidae", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9605", + "lbl" : "Homo", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9606", + "lbl" : "Homo sapiens", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/PATO_0000407", "type" : "CLASS" @@ -15818,12 +44881,18 @@ }, { "id" : "http://purl.obolibrary.org/obo/PATO_0000964", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0000998", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001171", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001375", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0001377", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001393", "type" : "CLASS" @@ -15851,12 +44920,18 @@ }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001690", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0001735", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001736", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001748", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0001873", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001908", "type" : "CLASS" @@ -15872,6 +44947,9 @@ }, { "id" : "http://purl.obolibrary.org/obo/PATO_0002045", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0002064", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0002078", "type" : "CLASS" @@ -15902,6 +44980,9 @@ }, { "id" : "http://purl.obolibrary.org/obo/PATO_0002462", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0002468", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0002478", "type" : "CLASS" @@ -16118,6 +45199,9 @@ }, { "id" : "http://purl.obolibrary.org/obo/PR_000007858", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PR_000009054", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PR_000009127", "type" : "CLASS" @@ -16130,154 +45214,952 @@ }, { "id" : "http://purl.obolibrary.org/obo/PR_000016043", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/SO_0000001", + "lbl" : "region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids.", + "xrefs" : [ "SO:ke" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/SO_0000110", + "lbl" : "sequence_feature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any extent of continuous biological sequence.", + "xrefs" : [ "LAMHDI:mb", "SO:ke" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/SO_0000704", + "lbl" : "gene", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions.", + "xrefs" : [ "SO:immuno_workshop" ] + }, + "comments" : [ "This term is mapped to MGED. Do not obsolete without consulting MGED ontology. A gene may be considered as a unit of inheritance." ], + "xrefs" : [ { + "val" : "http://en.wikipedia.org/wiki/Gene" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/SO_0001260", "lbl" : "sequence_collection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of discontinuous sequences.", + "xrefs" : [ "SO:ke" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/SO_0001411", + "lbl" : "biological_region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region defined by its disposition to be involved in a biological process.", + "xrefs" : [ "SO:cb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/SO_0005855", + "lbl" : "gene_group", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of related genes.", + "xrefs" : [ "SO:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000000", "lbl" : "processual entity", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity.", + "xrefs" : [ "span:ProcessualEntity" ] + }, + "xrefs" : [ { + "val" : "BFO:0000003" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000005", "lbl" : "chemosensory organ", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "lbl" : "islet of Langerhans", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The clusters of hormone-producing cells that are scattered throughout the pancreas.", + "xrefs" : [ "MA:0000127", "MESH:A03.734.414", "MP:0005215" ] + }, + "xrefs" : [ { + "val" : "AAO:0010406" + }, { + "val" : "BTO:0000991" + }, { + "val" : "CALOHA:TS-0741" + }, { + "val" : "EFO:0000856" + }, { + "val" : "EMAPA:32927" + }, { + "val" : "EV:0100130" + }, { + "val" : "FMA:16016" + }, { + "val" : "GAID:324" + }, { + "val" : "MA:0000127" + }, { + "val" : "MAT:0000076" + }, { + "val" : "MESH:D007515" + }, { + "val" : "MIAA:0000076" + }, { + "val" : "NCIT:C12608" + }, { + "val" : "VHOG:0000646" + }, { + "val" : "Wikipedia:Islets_of_Langerhans" + }, { + "val" : "XAO:0000159" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000009", "lbl" : "submucosa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Submucosa" ] + }, + "xrefs" : [ { + "val" : "BTO:0002107" + }, { + "val" : "FMA:85391" + }, { + "val" : "FMA:85392" + }, { + "val" : "NCIT:C13167" + }, { + "val" : "SCTID:68439008" + }, { + "val" : "Wikipedia:Submucosa" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000010", "lbl" : "peripheral nervous system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.", + "xrefs" : [ "GO:0007422" ] + }, + "xrefs" : [ { + "val" : "AAO:0000429" + }, { + "val" : "BAMS:PNS" + }, { + "val" : "BILA:0000081" + }, { + "val" : "BIRNLEX:1111" + }, { + "val" : "BTO:0001028" + }, { + "val" : "CALOHA:TS-0808" + }, { + "val" : "EFO:0000891" + }, { + "val" : "EHDAA2:0001445" + }, { + "val" : "EHDAA:2893" + }, { + "val" : "EMAPA:16665" + }, { + "val" : "EV:0100335" + }, { + "val" : "FMA:9903" + }, { + "val" : "GAID:715" + }, { + "val" : "MA:0000218" + }, { + "val" : "MAT:0000338" + }, { + "val" : "MESH:D017933" + }, { + "val" : "MIAA:0000338" + }, { + "val" : "NCIT:C12465" + }, { + "val" : "SCTID:362292005" + }, { + "val" : "TAO:0000142" + }, { + "val" : "VHOG:0000399" + }, { + "val" : "Wikipedia:Peripheral_nervous_system" + }, { + "val" : "XAO:0000178" + }, { + "val" : "ZFA:0000142" + }, { + "val" : "neuronames:3232" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000013", "lbl" : "sympathetic nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO].", + "xrefs" : [ "GO:0048485" ] + }, + "xrefs" : [ { + "val" : "AAO:0010487" + }, { + "val" : "BIRNLEX:2516" + }, { + "val" : "BTO:0001832" + }, { + "val" : "CALOHA:TS-2050" + }, { + "val" : "EFO:0000893" + }, { + "val" : "EHDAA2:0001971" + }, { + "val" : "EHDAA:3769" + }, { + "val" : "EMAPA:16985" + }, { + "val" : "FMA:9906" + }, { + "val" : "GAID:710" + }, { + "val" : "MA:0000225" + }, { + "val" : "MESH:D013564" + }, { + "val" : "MIAA:0000100" + }, { + "val" : "NCIT:C12795" + }, { + "val" : "SCTID:362484004" + }, { + "val" : "TAO:0001576" + }, { + "val" : "VHOG:0000384" + }, { + "val" : "Wikipedia:Sympathetic_nervous_system" + }, { + "val" : "ZFA:0001576" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000014", "lbl" : "zone of skin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis.", + "xrefs" : [ "Wikipedia:Skin", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA:6530" + }, { + "val" : "EV:0100152" + }, { + "val" : "FMA:86166" + }, { + "val" : "GAID:933" + }, { + "val" : "MA:0000151" + }, { + "val" : "MAT:0000284" + }, { + "val" : "MESH:D012867" + }, { + "val" : "MIAA:0000284" + }, { + "val" : "SCTID:20795001" + }, { + "val" : "VHOG:0000860" + }, { + "val" : "Wikipedia:Skin" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000015", "lbl" : "non-material anatomical boundary", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures.", + "xrefs" : [ "CARO:0000010" ] + }, + "comments" : [ "Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms." ], + "xrefs" : [ { + "val" : "AEO:0000192" + }, { + "val" : "CARO:0000010" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:50705" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "lbl" : "endocrine pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin.", + "xrefs" : [ "GO:GO", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000650" + }, { + "val" : "CALOHA:TS-1302" + }, { + "val" : "EFO:0002542" + }, { + "val" : "EMAPA:35305" + }, { + "val" : "EV:0100129" + }, { + "val" : "FMA:16018" + }, { + "val" : "MA:0001582" + }, { + "val" : "NCIT:C32509" + }, { + "val" : "SCTID:361339003" + }, { + "val" : "TAO:0001260" + }, { + "val" : "VHOG:0000049" + }, { + "val" : "Wikipedia:Islets_of_Langerhans" + }, { + "val" : "ZFA:0001260" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "lbl" : "exocrine pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO].", + "xrefs" : [ "GOC:GO", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010407" + }, { + "val" : "BTO:0000434" + }, { + "val" : "CALOHA:TS-1241" + }, { + "val" : "EMAPA:35328" + }, { + "val" : "EV:0100093" + }, { + "val" : "FMA:16017" + }, { + "val" : "MA:0002415" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "NCIT:C32546" + }, { + "val" : "SCTID:248202004" + }, { + "val" : "TAO:0001249" + }, { + "val" : "VHOG:0000048" + }, { + "val" : "Wikipedia:Exocrine_component_of_pancreas" + }, { + "val" : "XAO:0000137" + }, { + "val" : "ZFA:0001249" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000018", "lbl" : "compound eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A light sensing organ composed of ommatidia.", + "xrefs" : [ "FB:gg", "Wikipedia:Compound_eye" ] + }, + "xrefs" : [ { + "val" : "BTO:0001921" + }, { + "val" : "HAO:0000217" + }, { + "val" : "TGMA:0000024" + }, { + "val" : "Wikipedia:Compound_eye" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000019", "lbl" : "camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid.", + "xrefs" : [ "GO:0043010", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010340" + }, { + "val" : "BIRNLEX:1169" + }, { + "val" : "BTO:0004688" + }, { + "val" : "EHDAA2:0000484" + }, { + "val" : "EHDAA:936" + }, { + "val" : "EMAPA:16198" + }, { + "val" : "FMA:54448" + }, { + "val" : "MA:0000261" + }, { + "val" : "NCIT:C12401" + }, { + "val" : "SCTID:181143004" + }, { + "val" : "TAO:0000107" + }, { + "val" : "VHOG:0000275" + }, { + "val" : "XAO:0000179" + }, { + "val" : "ZFA:0000107" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000020", "lbl" : "sense organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that is capable of transducing sensory stimulus to the nervous system.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/549", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0000094" + }, { + "val" : "BSA:0000121" + }, { + "val" : "BTO:0000202" + }, { + "val" : "CALOHA:TS-2043" + }, { + "val" : "EHDAA2:0001824" + }, { + "val" : "EHDAA:500" + }, { + "val" : "EMAPA:35955" + }, { + "val" : "GAID:63" + }, { + "val" : "HAO:0000930" + }, { + "val" : "MA:0000017" + }, { + "val" : "MESH:D012679" + }, { + "val" : "NCIT:C33224" + }, { + "val" : "SCTID:244485009" + }, { + "val" : "VHOG:0001407" + }, { + "val" : "WBbt:0006929" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000025", "lbl" : "tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "galen:Tube" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000026", "lbl" : "appendage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Major subdivision of an organism that protrudes from the body[DOS, CARO].", + "xrefs" : [ "CARO:DOS" ] + }, + "xrefs" : [ { + "val" : "AEO:0000193" + }, { + "val" : "BILA:0000018" + }, { + "val" : "BTO:0001492" + }, { + "val" : "CARO:0010003" + }, { + "val" : "EFO:0000799" + }, { + "val" : "EHDAA2:0003193" + }, { + "val" : "EV:0100155" + }, { + "val" : "HAO:0000144" + }, { + "val" : "MAT:0000023" + }, { + "val" : "MESH:D005121" + }, { + "val" : "MIAA:0000023" + }, { + "val" : "NCIT:C61460" + }, { + "val" : "VSAO:0000075" + }, { + "val" : "Wikipedia:Appendage" + }, { + "val" : "XAO:0000218" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000030", "lbl" : "lamina propria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions.", + "xrefs" : [ "Wikipedia:Lamina_propria" ] + }, + "xrefs" : [ { + "val" : "BTO:0002330" + }, { + "val" : "FMA:62517" + }, { + "val" : "NCIT:C32918" + }, { + "val" : "SCTID:298225002" + }, { + "val" : "Wikipedia:Lamina_propria" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000031", "lbl" : "lamina propria of trachea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a respiratory airway.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35877" + }, { + "val" : "FMA:265157" + }, { + "val" : "MA:0001858" + }, { + "val" : "NCIT:C49305" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000033", "lbl" : "head", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The head is the anterior-most division of the body [GO].", + "xrefs" : [ "GO:0060322", "Wikipedia:Head" ] + }, + "xrefs" : [ { + "val" : "AAO:0010335" + }, { + "val" : "AEO:0000106" + }, { + "val" : "BILA:0000115" + }, { + "val" : "BIRNLEX:1230" + }, { + "val" : "BTO:0000282" + }, { + "val" : "CALOHA:TS-0436" + }, { + "val" : "EFO:0000964" + }, { + "val" : "EHDAA2:0003106" + }, { + "val" : "EMAPA:31858" + }, { + "val" : "FMA:7154" + }, { + "val" : "GAID:61" + }, { + "val" : "HAO:0000397" + }, { + "val" : "MA:0000023" + }, { + "val" : "MAT:0000294" + }, { + "val" : "MESH:D006257" + }, { + "val" : "MIAA:0000294" + }, { + "val" : "NCIT:C12419" + }, { + "val" : "SCTID:302548004" + }, { + "val" : "SPD:0000016" + }, { + "val" : "TAO:0001114" + }, { + "val" : "TGMA:0000002" + }, { + "val" : "VHOG:0001644" + }, { + "val" : "WBbt:0005739" + }, { + "val" : "Wikipedia:Head" + }, { + "val" : "XAO:0003024" + }, { + "val" : "ZFA:0001114" + }, { + "val" : "galen:Head" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000042", "lbl" : "serous membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer.", + "xrefs" : [ "Wikipedia:Serous_membrane", "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "FMA:9581" + }, { + "val" : "GAID:19" + }, { + "val" : "MESH:D012704" + }, { + "val" : "NCIT:C13169" + }, { + "val" : "SCTID:362878009" + }, { + "val" : "TAO:0005425" + }, { + "val" : "Wikipedia:Serous_membrane" + }, { + "val" : "ZFA:0005425" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000043", "lbl" : "tendon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dense regular connective tissue that connects muscle to bone[VSAO].", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000073", "Wikipedia:Tendon", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AEO:0000091" + }, { + "val" : "BTO:0001356" + }, { + "val" : "CALOHA:TS-1021" + }, { + "val" : "EHDAA2:0003091" + }, { + "val" : "EMAPA:35854" + }, { + "val" : "EV:0100149" + }, { + "val" : "FMA:9721" + }, { + "val" : "GAID:276" + }, { + "val" : "MA:0000115" + }, { + "val" : "MESH:D013710" + }, { + "val" : "NCIT:C13045" + }, { + "val" : "SCTID:256667004" + }, { + "val" : "VHOG:0001286" + }, { + "val" : "VSAO:0000073" + }, { + "val" : "Wikipedia:Tendon" + }, { + "val" : "XAO:0000173" + }, { + "val" : "ZFA:0005647" + }, { + "val" : "galen:Tendon" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000045", "lbl" : "ganglion", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A biological tissue mass, most commonly a mass of nerve cell bodies.", + "xrefs" : [ "Wikipedia:Ganglion", "https://github.com/obophenotype/uberon/issues/300" ] + }, + "xrefs" : [ { + "val" : "AAO:0010426" + }, { + "val" : "AEO:0000135" + }, { + "val" : "BAMS:G" + }, { + "val" : "BTO:0000497" + }, { + "val" : "CALOHA:TS-0397" + }, { + "val" : "EFO:0000899" + }, { + "val" : "EHDAA2:0003135" + }, { + "val" : "EHDAA:2897" + }, { + "val" : "EHDAA:4662" + }, { + "val" : "EHDAA:5621" + }, { + "val" : "EHDAA:918" + }, { + "val" : "EMAPA:32846" + }, { + "val" : "EV:0100372" + }, { + "val" : "FMA:5884" + }, { + "val" : "MA:0002406" + }, { + "val" : "MAT:0000207" + }, { + "val" : "MAT:0000343" + }, { + "val" : "MESH:D005724" + }, { + "val" : "MIAA:0000207" + }, { + "val" : "MIAA:0000343" + }, { + "val" : "NCIT:C12719" + }, { + "val" : "NLXANAT:100302" + }, { + "val" : "TAO:0000190" + }, { + "val" : "TGMA:0001016" + }, { + "val" : "VHOG:0000156" + }, { + "val" : "WBbt:0005189" + }, { + "val" : "Wikipedia:Ganglion" + }, { + "val" : "XAO:0000209" + }, { + "val" : "ZFA:0000190" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000047", "lbl" : "simple eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity.", + "xrefs" : [ "Wikipedia:Eye#Simple_eyes" ] + }, + "xrefs" : [ { + "val" : "TGMA:0000729" + }, { + "val" : "Wikipedia:Eye#Simple_eyes" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000055", "lbl" : "vessel", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A tubular structure that contains, conveys body fluid, such as blood or lymph.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000058", "lbl" : "duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tubular structure that transports secreted or excreted substances.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm#ducts" ] + }, + "xrefs" : [ { + "val" : "AAO:0011123" + }, { + "val" : "FMA:30320" + }, { + "val" : "NCIT:C12948" + }, { + "val" : "SCTID:91726008" + }, { + "val" : "TAO:0005171" + }, { + "val" : "Wikipedia:Duct_(anatomy)" + }, { + "val" : "XAO:0004000" + }, { + "val" : "ZFA:0005171" + }, { + "val" : "galen:Duct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "lbl" : "large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong].", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Large_intestine_(anatomy)" ] + }, + "xrefs" : [ { + "val" : "AAO:0010396" + }, { + "val" : "BTO:0000706" + }, { + "val" : "CALOHA:TS-1306" + }, { + "val" : "EFO:0000840" + }, { + "val" : "EMAPA:19252" + }, { + "val" : "EV:0100077" + }, { + "val" : "FMA:7201" + }, { + "val" : "GAID:306" + }, { + "val" : "MA:0000333" + }, { + "val" : "MESH:D007420" + }, { + "val" : "MIAA:0000046" + }, { + "val" : "NCIT:C12379" + }, { + "val" : "SCTID:181254001" + }, { + "val" : "VHOG:0000054" + }, { + "val" : "Wikipedia:Large_intestine_(anatomy)" + }, { + "val" : "XAO:0000131" + }, { + "val" : "galen:LargeIntestine" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000060", "lbl" : "anatomical wall", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers.", + "xrefs" : [ "FMA:82482" ] + }, + "xrefs" : [ { + "val" : "FMA:82482" + }, { + "val" : "galen:Wall" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000061", "lbl" : "anatomical structure", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.", + "xrefs" : [ "CARO:0000003" ] + }, + "xrefs" : [ { + "val" : "AAO:0010825" + }, { + "val" : "AEO:0000003" + }, { + "val" : "BILA:0000003" + }, { + "val" : "CARO:0000003" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "EHDAA2:0003003" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "EMAPA:0" + }, { + "val" : "FMA:305751" + }, { + "val" : "FMA:67135" + }, { + "val" : "GAID:781" + }, { + "val" : "HAO:0000003" + }, { + "val" : "MA:0003000" + }, { + "val" : "MESH:D000825" + }, { + "val" : "SCTID:362889002" + }, { + "val" : "TAO:0000037" + }, { + "val" : "TGMA:0001823" + }, { + "val" : "VHOG:0001759" + }, { + "val" : "XAO:0003000" + }, { + "val" : "ZFA:0000037" + }, { + "val" : "http://dbpedia.org/ontology/AnatomicalStructure" } ] } }, { @@ -16285,35 +46167,68 @@ "lbl" : "organ", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Anatomical structure that performs a specific function or group of functions [WP].", + "xrefs" : [ "Wikipedia:Organ_(anatomy)" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:4" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "CARO:0020004" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "EFO:0000634" + }, { + "val" : "EMAPA:35949" + }, { + "val" : "ENVO:01000162" + }, { + "val" : "FMA:67498" + }, { + "val" : "MA:0003001" + }, { + "val" : "NCIT:C13018" + }, { + "val" : "SCTID:272625005" + }, { + "val" : "WBbt:0003760" + }, { + "val" : "Wikipedia:Organ_(anatomy)" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000063", "lbl" : "organ subunit", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:86140" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000064", "lbl" : "organ part", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "A multicellular structure that is a part of an organ.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011124" + }, { + "val" : "BIRNLEX:16" + }, { + "val" : "EFO:0000635" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:82472" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "SCTID:113343008" + }, { + "val" : "SCTID:91717005" } ] } }, { @@ -16321,119 +46236,457 @@ "lbl" : "respiratory tract", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001606" + }, { + "val" : "EHDAA:1568" + }, { + "val" : "EHDAA:2219" + }, { + "val" : "EMAPA:16737" + }, { + "val" : "FMA:265130" + }, { + "val" : "SCTID:361110005" + }, { + "val" : "VHOG:0000393" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000066", "lbl" : "fully formed stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001043" + }, { + "val" : "BilaDO:0000004" + }, { + "val" : "EFO:0001272" + }, { + "val" : "FBdv:00005369" + }, { + "val" : "WBls:0000041" + }, { + "val" : "XtroDO:0000084" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000068", "lbl" : "embryo stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A life cycle stage that starts with fertilization and ends with the fully formed embryo.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BilaDO:0000002" + }, { + "val" : "EV:0300001" + }, { + "val" : "FBdv:00005289" + }, { + "val" : "FMA:72652" + }, { + "val" : "HsapDv:0000002" + }, { + "val" : "MmusDv:0000002" + }, { + "val" : "OGES:000000" + }, { + "val" : "OGES:000022" + }, { + "val" : "SCTID:296280003" + }, { + "val" : "WBls:0000003" + }, { + "val" : "WBls:0000092" + }, { + "val" : "WBls:0000102" + }, { + "val" : "XAO:1000012" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000071", "lbl" : "death stage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "definition" : { + "val" : "End of the life of an organism.", + "xrefs" : [ "XAO:0000437" ] + }, + "xrefs" : [ { + "val" : "XAO:0000437" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "XtroDO:0000085" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000072", "lbl" : "proximo-distal subdivision of respiratory tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An section of a respiratory tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:45660" + }, { + "val" : "MA:0000434" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000073", "lbl" : "regional part of nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS.", + "xrefs" : [ "BIRNLEX:1157" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1157" + }, { + "val" : "NCIT:C13040" + }, { + "val" : "SCTID:25087005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000075", "lbl" : "subdivision of skeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.", + "xrefs" : [ "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:85544" + }, { + "val" : "NCIT:C34076" + }, { + "val" : "SCTID:118966000" + }, { + "val" : "galen:ComplexSkeletalStructure" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000076", "lbl" : "external ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm.", + "xrefs" : [ "MGI:anna", "MP:0012532" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001968" + }, { + "val" : "EHDAA:1494" + }, { + "val" : "EHDAA:350" + }, { + "val" : "EHDAA:4784" + }, { + "val" : "EHDAA:4790" + }, { + "val" : "EHDAA:4796" + }, { + "val" : "EHDAA:7860" + }, { + "val" : "EMAPA:16096" + }, { + "val" : "FMA:87656" + }, { + "val" : "NCIT:C34309" + }, { + "val" : "Wikipedia:External_ectoderm" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000077", "lbl" : "mixed endoderm/mesoderm-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops from the endoderm and the mesoderm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000078", "lbl" : "mixed ectoderm/mesoderm/endoderm-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops from the ectoderm, mesoderm and endoderm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000085", "lbl" : "morula", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum.", + "xrefs" : [ "MP:0012130" ] + }, + "xrefs" : [ { + "val" : "BTO:0001508" + }, { + "val" : "EHDAA2:0000005" + }, { + "val" : "FMA:292334" + }, { + "val" : "GAID:1295" + }, { + "val" : "MESH:D009028" + }, { + "val" : "NCIT:C34212" + }, { + "val" : "SCTID:361474003" + }, { + "val" : "Wikipedia:Morula" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000086", "lbl" : "zona pellucida", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes.", + "xrefs" : [ "Wikipedia:Zona_pellucida" ] + }, + "xrefs" : [ { + "val" : "BTO:0003135" + }, { + "val" : "EHDAA2:0002220" + }, { + "val" : "EHDAA:31" + }, { + "val" : "EHDAA:62" + }, { + "val" : "EMAPA:16035" + }, { + "val" : "FMA:18674" + }, { + "val" : "GAID:410" + }, { + "val" : "MA:0001715" + }, { + "val" : "MESH:D015044" + }, { + "val" : "NCIT:C33896" + }, { + "val" : "TAO:0001111" + }, { + "val" : "Wikipedia:Zona_pellucida" + }, { + "val" : "ZFA:0001111" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000087", "lbl" : "inner cell mass", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mass of cells that develop into the body of the embryo and some extraembryonic tissues.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:pvb" ] + }, + "xrefs" : [ { + "val" : "EFO:0000547" + }, { + "val" : "EHDAA2:0000830" + }, { + "val" : "EHDAA:40" + }, { + "val" : "EMAPA:16041" + }, { + "val" : "FMA:86557" + }, { + "val" : "NCIT:C13740" + }, { + "val" : "SCTID:361456007" + }, { + "val" : "VHOG:0000742" + }, { + "val" : "Wikipedia:Inner_cell_mass" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000088", "lbl" : "trophoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0005031" ] + }, + "comments" : [ "Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast]" ], + "xrefs" : [ { + "val" : "BTO:0001079" + }, { + "val" : "CALOHA:TS-1070" + }, { + "val" : "EV:0100120" + }, { + "val" : "FMA:83029" + }, { + "val" : "GAID:1152" + }, { + "val" : "MESH:D014327" + }, { + "val" : "NCIT:C93292" + }, { + "val" : "SCTID:362839005" + }, { + "val" : "Wikipedia:Trophoblast" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000091", "lbl" : "bilaminar disc", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc.", + "xrefs" : [ "MP:0003886" ] + }, + "xrefs" : [ { + "val" : "FMA:293863" + }, { + "val" : "NCIT:C34112" + }, { + "val" : "Wikipedia:Bilaminar_disc" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000092", "lbl" : "post-embryonic stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Stage succeeding embryo, including mature structure.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BilaDO:0000003" + }, { + "val" : "OGES:000010" + }, { + "val" : "OGES:000014" + }, { + "val" : "OGES:000024" + }, { + "val" : "WBls:0000022" + }, { + "val" : "WBls:0000093" + }, { + "val" : "WBls:0000103" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000094", "lbl" : "membrane organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA].", + "xrefs" : [ "FMA:7145" ] + }, + "xrefs" : [ { + "val" : "FMA:7145" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000095", "lbl" : "cardiac neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia].", + "xrefs" : [ "Wikipedia:Cardiac_neural_crest" ] + }, + "xrefs" : [ { + "val" : "TAO:0002173" + }, { + "val" : "Wikipedia:Cardiac_neural_crest" + }, { + "val" : "XAO:0004190" + }, { + "val" : "ZFA:0001648" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000101", "lbl" : "lobe of lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lung lobe is one of the rounded projections that compose the lung[GO].", + "xrefs" : [ "GOC:GO" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36281" + }, { + "val" : "FMA:7311" + }, { + "val" : "MA:0003098" + }, { + "val" : "NCIT:C34021" + }, { + "val" : "SCTID:245524004" + }, { + "val" : "galen:LobeOfLung" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000102", "lbl" : "lung vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO].", + "xrefs" : [ "GOC:GO" ] + }, + "xrefs" : [ { + "val" : "FMA:73750" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000104", "lbl" : "life cycle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FBdv:00000000" + }, { + "val" : "HsapDv:0000001" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "MmusDv:0000001" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "OGES:000011" + }, { + "val" : "ncithesaurus:Life" } ] } }, { @@ -16441,3108 +46694,19551 @@ "lbl" : "life cycle stage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "A spatiotemporal region encompassing some part of the life cycle of an organism.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BILS:0000105" + }, { + "val" : "EFO:0000399" + }, { + "val" : "FBdv:00007012" + }, { + "val" : "FMA:24120" + }, { + "val" : "HsapDv:0000000" + }, { + "val" : "MESH:D008018" + }, { + "val" : "MmusDv:0000000" + }, { + "val" : "OlatDv:0000010" + }, { + "val" : "PdumDv:0000090" + }, { + "val" : "WBls:0000002" + }, { + "val" : "XAO:1000000" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "ZFS:0000000" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "ZFS:0100000" + }, { + "val" : "ncithesaurus:Developmental_Stage" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000106", "lbl" : "zygote stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stage at which the organism is a single cell produced by means of sexual reproduction.", + "xrefs" : [ "Wikipedia:Zygote" ] + }, + "xrefs" : [ { + "val" : "BILS:0000106" + }, { + "val" : "BilaDO:0000005" + }, { + "val" : "EFO:0001322" + }, { + "val" : "EHDAA:27" + }, { + "val" : "FBdv:00005288" + }, { + "val" : "NCIT:C12601" + }, { + "val" : "PdumDv:0000100" + }, { + "val" : "VHOG:0000745" + }, { + "val" : "Wikipedia:Zygote" + }, { + "val" : "XAO:1000001" + }, { + "val" : "ZFS:0000001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000107", "lbl" : "cleavage stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.", + "xrefs" : [ "GO:0040016", "Wikipedia:Cleavage_(embryo)" ] + }, + "xrefs" : [ { + "val" : "BILS:0000107" + }, { + "val" : "BilaDO:0000006" + }, { + "val" : "EFO:0001290" + }, { + "val" : "FBdv:00000054" + }, { + "val" : "MESH:D002970" + }, { + "val" : "MmusDv:0000004" + }, { + "val" : "OGES:000015" + }, { + "val" : "OGES:000020" + }, { + "val" : "PdumDv:0000200" + }, { + "val" : "Wikipedia:Cleavage_(embryo)" + }, { + "val" : "XAO:1000004" + }, { + "val" : "ZFS:0000046" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000108", "lbl" : "blastula stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.", + "xrefs" : [ "Wikipedia:Blastula" ] + }, + "xrefs" : [ { + "val" : "BILS:0000108" + }, { + "val" : "BilaDO:0000007" + }, { + "val" : "EFO:0001282" + }, { + "val" : "HsapDv:0000006" + }, { + "val" : "MmusDv:0000007" + }, { + "val" : "OGES:000003" + }, { + "val" : "OGES:000016" + }, { + "val" : "OGES:000021" + }, { + "val" : "WBls:0000005" + }, { + "val" : "Wikipedia:Blastula" + }, { + "val" : "XAO:1000003" + }, { + "val" : "ZFS:0000045" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000109", "lbl" : "gastrula stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.", + "xrefs" : [ "GO:0007369" ] + }, + "xrefs" : [ { + "val" : "BILS:0000109" + }, { + "val" : "BilaDO:0000008" + }, { + "val" : "EFO:0001296" + }, { + "val" : "FBdv:00005317" + }, { + "val" : "HsapDv:0000010" + }, { + "val" : "MmusDv:0000013" + }, { + "val" : "OGES:000004" + }, { + "val" : "OGES:000019" + }, { + "val" : "WBls:0000010" + }, { + "val" : "XAO:1000005" + }, { + "val" : "ZFS:0000047" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000110", "lbl" : "neurula stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.", + "xrefs" : [ "GO:0001841" ] + }, + "xrefs" : [ { + "val" : "BILS:0000110" + }, { + "val" : "BilaDO:0000009" + }, { + "val" : "HsapDv:0000012" + }, { + "val" : "MmusDv:0000017" + }, { + "val" : "XAO:1000006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000111", "lbl" : "organogenesis stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.", + "xrefs" : [ "Wikipedia:Organogenesis" ] + }, + "xrefs" : [ { + "val" : "BILS:0000111" + }, { + "val" : "BilaDO:0000010" + }, { + "val" : "HsapDv:0000015" + }, { + "val" : "MmusDv:0000018" + }, { + "val" : "OGES:000005" + }, { + "val" : "OGES:000032" + }, { + "val" : "Wikipedia:Organogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000114", "lbl" : "lung connective tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:anna", "MP:0002276", "PMID:14635660" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35521" + }, { + "val" : "FMA:27533" + }, { + "val" : "MA:0001782" + }, { + "val" : "SCTID:201609008" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000115", "lbl" : "lung epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial layer of the lung.", + "xrefs" : [ "MP:0006382" ] + }, + "xrefs" : [ { + "val" : "BTO:0001653" + }, { + "val" : "EMAPA:32860" + }, { + "val" : "MA:0001783" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000117", "lbl" : "respiratory tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea.", + "xrefs" : [ "GO:0030323", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:12224" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000118", "lbl" : "lung bud", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000122", - "lbl" : "neuron projection bundle", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000125", - "lbl" : "neural nucleus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000126", - "lbl" : "cranial nerve nucleus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000153", - "lbl" : "anterior region of body", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000154", - "lbl" : "posterior region of body", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000158", - "lbl" : "membranous layer", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000161", - "lbl" : "orifice", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000165", - "lbl" : "mouth", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000166", - "lbl" : "oral opening", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000167", - "lbl" : "oral cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000170", - "lbl" : "pair of lungs", - "type" : "CLASS", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000171", - "lbl" : "respiration organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000178", - "lbl" : "blood", - "type" : "CLASS", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000179", - "lbl" : "haemolymphatic fluid", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000304", - "lbl" : "tendon sheath", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000307", - "lbl" : "blastula", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000325", - "lbl" : "gastric gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000328", - "lbl" : "gut wall", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000332", - "lbl" : "yellow bone marrow", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000344", - "lbl" : "mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000353", - "lbl" : "parenchyma", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000355", - "lbl" : "pharyngeal mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000358", - "lbl" : "blastocyst", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000361", - "lbl" : "red bone marrow", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000371", - "lbl" : "syncytiotrophoblast", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000377", - "lbl" : "maxillary nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Structure derived from foregut that becomes a lung[GO].", + "xrefs" : [ "GO:0060431", "Wikipedia:Respiratory_bud" ] + }, + "xrefs" : [ { + "val" : "BTO:0001643" + }, { + "val" : "EHDAA2:0004089" + }, { + "val" : "NCIT:C34260" + }, { + "val" : "NCIT:C34282" + }, { + "val" : "SCTID:361427007" + }, { + "val" : "Wikipedia:Respiratory_bud" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000379", - "lbl" : "tracheal mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000383", - "lbl" : "musculature of body", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000122", + "lbl" : "neuron projection bundle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.", + "xrefs" : [ "CARO:0001001", "FBC:DOS", "FBbt:00005099" ] + }, + "xrefs" : [ { + "val" : "CARO:0001001" + }, { + "val" : "NLX:147821" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000389", - "lbl" : "lens cortex", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000125", + "lbl" : "neural nucleus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO).", + "xrefs" : [ "NLX:28443" ] + }, + "xrefs" : [ { + "val" : "AEO:0000136" + }, { + "val" : "FMA:83686" + }, { + "val" : "NCIT:C13197" + }, { + "val" : "NLX:28443" + }, { + "val" : "Wikipedia:Nucleus_(neuroanatomy)" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000390", - "lbl" : "lens nucleus", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000126", + "lbl" : "cranial nerve nucleus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves.", + "xrefs" : [ "NLX:28532" ] + }, + "xrefs" : [ { + "val" : "FMA:54501" + }, { + "val" : "NLX:28532" + }, { + "val" : "SCTID:280160003" + }, { + "val" : "Wikipedia:Cranial_nerve_nucleus" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000409", - "lbl" : "serous gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000410", - "lbl" : "bronchial mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000415", - "lbl" : "artery wall", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000153", + "lbl" : "anterior region of body", "type" : "CLASS" }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000456", - "lbl" : "secretion of exocrine gland", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000154", + "lbl" : "posterior region of body", "type" : "CLASS" }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000463", - "lbl" : "organism substance", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000158", + "lbl" : "membranous layer", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "xrefs" : [ { + "val" : "FMA:30322" + }, { + "val" : "FMA:82500" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "MESH:D008566" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "NCIT:C12749" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000464", - "lbl" : "anatomical space", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "lbl" : "anal canal", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus.", + "xrefs" : [ "Wikipedia:Anal_canal" ] + }, + "xrefs" : [ { + "val" : "BTO:0001978" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "CALOHA:TS-2160" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000465", - "lbl" : "material anatomical entity", - "type" : "CLASS", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "val" : "EMAPA:18256" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:15703" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000466", - "lbl" : "immaterial anatomical entity", - "type" : "CLASS", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "val" : "MA:0000330" + }, { + "val" : "NCIT:C12375" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "SCTID:245438008" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "Wikipedia:Anal_canal" + }, { + "val" : "galen:AnalCanal" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000467", - "lbl" : "anatomical system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000160", + "lbl" : "intestine", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine.", + "xrefs" : [ "GOC:GO", "Wikipedia:Intestine" ] + }, + "xrefs" : [ { + "val" : "AAO:0000246" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "ANISEED:1235303" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "BSA:0000093" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000468", - "lbl" : "multicellular organism", - "type" : "CLASS", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "val" : "BTO:0000648" + }, { + "val" : "CALOHA:TS-0490" + }, { + "val" : "EFO:0000834" + }, { + "val" : "EMAPA:32874" + }, { + "val" : "EV:0100071" + }, { + "val" : "FMA:7199" + }, { + "val" : "GAID:295" + }, { + "val" : "MA:0000328" + }, { + "val" : "MA:0001524" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "MESH:D007422" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "MIAA:0000043" + }, { + "val" : "NCIT:C12736" + }, { + "val" : "SCTID:256876008" + }, { + "val" : "TAO:0001338" + }, { + "val" : "VHOG:0000056" + }, { + "val" : "WBbt:0005772" + }, { + "val" : "Wikipedia:Intestine" + }, { + "val" : "XAO:0000129" + }, { + "val" : "ZFA:0001338" + }, { + "val" : "galen:Intestine" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000474", - "lbl" : "female reproductive system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000161", + "lbl" : "orifice", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified].", + "xrefs" : [ "FMA:3724" ] + }, + "xrefs" : [ { + "val" : "FMA:3724" + }, { + "val" : "SCTID:91837002" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000475", - "lbl" : "organism subdivision", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000162", + "lbl" : "cloaca", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Cloaca" ] + }, + "xrefs" : [ { + "val" : "AAO:0000095" + }, { + "val" : "GAID:1206" + }, { + "val" : "MESH:D002988" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "NCIT:C34127" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "SCTID:362857006" + }, { + "val" : "SCTID:370631000" + }, { + "val" : "VHOG:0001186" + }, { + "val" : "Wikipedia:Cloaca" + }, { + "val" : "XAO:0000244" + }, { + "val" : "ZFA:0005781" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000476", - "lbl" : "acellular anatomical structure", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "lbl" : "embryonic cloaca", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP].", + "xrefs" : [ "MP:0010115", "Wikipedia:Cloaca_(embryology)" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000256" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "EHDAA:4895" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "EMAPA:27573" + }, { + "val" : "Wikipedia:Cloaca_(embryology)" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000477", - "lbl" : "anatomical cluster", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000165", + "lbl" : "mouth", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks).", + "xrefs" : [ "Wikipedia:Mouth", "https://github.com/obophenotype/uberon/wiki/The-digestive-tract" ] + }, + "xrefs" : [ { + "val" : "AAO:0010355" + }, { + "val" : "BTO:0001090" + }, { + "val" : "BTO:0004698" + }, { + "val" : "CALOHA:TS-1315" + }, { + "val" : "EFO:0000825" + }, { + "val" : "EHDAA2:0001326" + }, { + "val" : "EHDAA:542" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "EMAPA:16262" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "FMA:49184" + }, { + "val" : "GAID:75" + }, { + "val" : "MA:0000341" + }, { + "val" : "MA:0002474" + }, { + "val" : "MAT:0000038" + }, { + "val" : "MESH:D009055" + }, { + "val" : "MIAA:0000038" + }, { + "val" : "SCTID:21082005" + }, { + "val" : "TADS:0000040" + }, { + "val" : "TAO:0000547" + }, { + "val" : "TAO:0000590" + }, { + "val" : "TGMA:0000131" + }, { + "val" : "VHOG:0000280" + }, { + "val" : "VHOG:0000812" + }, { + "val" : "Wikipedia:Mouth" + }, { + "val" : "XAO:0003029" + }, { + "val" : "ZFA:0000547" + }, { + "val" : "ZFA:0000590" + }, { + "val" : "galen:Mouth" + }, { + "val" : "http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000478", - "lbl" : "extraembryonic structure", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000479", - "lbl" : "tissue", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000166", + "lbl" : "oral opening", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "The orifice that connects the mouth to the exterior of the body.", + "xrefs" : [ "https://github.com/obophenotype/uberon/wiki/The-digestive-tract" ] + }, + "xrefs" : [ { + "val" : "FMA:59806" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000481", - "lbl" : "multi-tissue structure", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000167", + "lbl" : "oral cavity", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present).", + "xrefs" : [ "ISBN:0073040584", "https://github.com/obophenotype/uberon/wiki/The-digestive-tract", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000053" + }, { + "val" : "AAO:0000960" + }, { + "val" : "BSA:0000107" + }, { + "val" : "CALOHA:TS-1315" + }, { + "val" : "EFO:0001975" + }, { + "val" : "EHDAA2:0001324" + }, { + "val" : "EHDAA:6970" + }, { + "val" : "EMAPA:17411" + }, { + "val" : "EMAPA:18399" + }, { + "val" : "EV:0100057" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:20292" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "HAO:0000669" + }, { + "val" : "NCIT:C12421" + }, { + "val" : "SCTID:181220002" + }, { + "val" : "TAO:0001027" + }, { + "val" : "TGMA:0000102" + }, { + "val" : "VHOG:0000188" + }, { + "val" : "WBbt:0005255" + }, { + "val" : "XAO:0000126" + }, { + "val" : "ZFA:0001027" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000483", - "lbl" : "epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000484", - "lbl" : "simple cuboidal epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000485", - "lbl" : "simple columnar epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000486", - "lbl" : "multilaminar epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000487", - "lbl" : "simple squamous epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000488", - "lbl" : "atypical epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000489", - "lbl" : "cavitated compound organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000490", - "lbl" : "unilaminar epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000915", - "lbl" : "thoracic segment of trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000916", - "lbl" : "abdomen", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000922", - "lbl" : "embryo", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000923", - "lbl" : "germ layer", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000924", - "lbl" : "ectoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000925", - "lbl" : "endoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000926", - "lbl" : "mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000930", - "lbl" : "stomodeum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000945", - "lbl" : "stomach", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000168", + "lbl" : "proximal-distal subdivision of colon", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A section dividing a colon along a proximal-distal axis.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:222905" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000947", - "lbl" : "aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000170", + "lbl" : "pair of lungs", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The pair of anatomical structures comprised of a left lung and right lung.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:68877" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000948", - "lbl" : "heart", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000171", + "lbl" : "respiration organ", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.", + "xrefs" : [ "GO:0007585" ] + }, + "xrefs" : [ { + "val" : "SCTID:272626006" + }, { + "val" : "SPD:0000428" + }, { + "val" : "TGMA:0001247" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000949", - "lbl" : "endocrine system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000955", - "lbl" : "brain", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000174", + "lbl" : "excreta", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity.", + "xrefs" : [ "GO:0007588", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0000184" + }, { + "val" : "BTO:0000491" + }, { + "val" : "EHDAA2_RETIRED:0003184" + }, { + "val" : "ENVO:02000022" + }, { + "val" : "FMA:9674" + }, { + "val" : "galen:Excretion" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000957", - "lbl" : "lamina", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000962", - "lbl" : "nerve of cervical vertebra", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000178", + "lbl" : "blood", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A fluid that is composed of blood plasma and erythrocytes.", + "xrefs" : [ "FMA:9670", "Wikipedia:Blood", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/9" ] + }, + "xrefs" : [ { + "val" : "AAO:0000046" + }, { + "val" : "BTO:0000089" + }, { + "val" : "CALOHA:TS-0079" + }, { + "val" : "EFO:0000296" + }, { + "val" : "EHDAA2:0000176" + }, { + "val" : "EHDAA:418" + }, { + "val" : "EMAPA:16332" + }, { + "val" : "ENVO:02000027" + }, { + "val" : "EV:0100047" + }, { + "val" : "FMA:9670" + }, { + "val" : "GAID:965" + }, { + "val" : "MA:0000059" + }, { + "val" : "MESH:D001769" + }, { + "val" : "MIAA:0000315" + }, { + "val" : "NCIT:C12434" + }, { + "val" : "TAO:0000007" + }, { + "val" : "VHOG:0000224" + }, { + "val" : "Wikipedia:Blood" + }, { + "val" : "XAO:0000124" + }, { + "val" : "ZFA:0000007" + }, { + "val" : "galen:Blood" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000963", - "lbl" : "head sensillum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000964", - "lbl" : "cornea", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000179", + "lbl" : "haemolymphatic fluid", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "CARO:0000081" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000965", - "lbl" : "lens of camera-type eye", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "lbl" : "tetrapod frontal bone", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The bone forming the forehead and roof of the eye orbit.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0000107", "PMID:7914451", "Wikipedia:Frontal_bone" ] + }, + "xrefs" : [ { + "val" : "AAO:0000206" + }, { + "val" : "EMAPA:19016" + }, { + "val" : "FMA:52734" + }, { + "val" : "GAID:226" + }, { + "val" : "MA:0001466" + }, { + "val" : "MESH:D005624" + }, { + "val" : "NCIT:C32635" + }, { + "val" : "SCTID:181793006" + }, { + "val" : "VSAO:0000208" + }, { + "val" : "Wikipedia:Frontal_bone" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000966", - "lbl" : "retina", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "lbl" : "atlanto-occipital joint", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital.", + "xrefs" : [ "Wikipedia:Atlanto-occipital_joint" ] + }, + "xrefs" : [ { + "val" : "FMA:24939" + }, { + "val" : "NCIT:C32158" + }, { + "val" : "SCTID:361831006" + }, { + "val" : "Wikipedia:Atlanto-occipital_joint" + }, { + "val" : "ncithesaurus:Atlanto-occipital_Joint-Atlanto" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000970", - "lbl" : "eye", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000304", + "lbl" : "tendon sheath", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath.", + "xrefs" : [ "Wikipedia:Tendon_sheath" ] + }, + "xrefs" : [ { + "val" : "BTO:0000051" + }, { + "val" : "FMA:45087" + }, { + "val" : "FMA:76715" + }, { + "val" : "NCIT:C96299" + }, { + "val" : "SCTID:361885006" + }, { + "val" : "Wikipedia:Tendon_sheath" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000971", - "lbl" : "ommatidium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000974", - "lbl" : "neck", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000977", - "lbl" : "pleura", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000982", - "lbl" : "skeletal joint", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000988", - "lbl" : "pons", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000307", + "lbl" : "blastula", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.", + "xrefs" : [ "Wikipedia:Blastula" ] + }, + "xrefs" : [ { + "val" : "BILA:0000059" + }, { + "val" : "BTO:0000128" + }, { + "val" : "GAID:1294" + }, { + "val" : "MESH:D036703" + }, { + "val" : "OGEM:000006" + }, { + "val" : "Wikipedia:Blastula" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000990", - "lbl" : "reproductive system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000317", + "lbl" : "colonic mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000271" + }, { + "val" : "CALOHA:TS-0164" + }, { + "val" : "EFO:0003038" + }, { + "val" : "EMAPA:27375" + }, { + "val" : "FMA:14984" + }, { + "val" : "FMA:85388" + }, { + "val" : "MA:0003194" + }, { + "val" : "SCTID:362157008" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000991", - "lbl" : "gonad", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000992", - "lbl" : "ovary", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000320", + "lbl" : "duodenal mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mucosa that is part of a duodenum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000367" + }, { + "val" : "CALOHA:TS-0213" + }, { + "val" : "EMAPA:27235" + }, { + "val" : "FMA:14942" + }, { + "val" : "MA:0003207" + }, { + "val" : "SCTID:362146003" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001003", - "lbl" : "skin epidermis", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000325", + "lbl" : "gastric gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin.", + "xrefs" : [ "MGI:anna" ] + }, + "xrefs" : [ { + "val" : "BTO:0000503" + }, { + "val" : "EMAPA:27181" + }, { + "val" : "FMA:14919" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001004", - "lbl" : "respiratory system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000326", + "lbl" : "pancreatic juice", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.", + "xrefs" : [ "GO:0030157" ] + }, + "xrefs" : [ { + "val" : "BTO:0000504" + }, { + "val" : "CALOHA:TS-2235" + }, { + "val" : "FMA:62973" + }, { + "val" : "GAID:1166" + }, { + "val" : "MESH:D010189" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001005", - "lbl" : "respiratory airway", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001007", - "lbl" : "digestive system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000328", + "lbl" : "gut wall", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000547" + }, { + "val" : "FMA:45653" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001009", - "lbl" : "circulatory system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000332", + "lbl" : "yellow bone marrow", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Bone marrow in which the fat cells predominate in the meshes of the reticular network.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/Yellow+Marrow" ] + }, + "xrefs" : [ { + "val" : "BTO:0000635" + }, { + "val" : "FMA:74596" + }, { + "val" : "SCTID:328639002" + }, { + "val" : "SCTID:5023006" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001013", - "lbl" : "adipose tissue", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000333", + "lbl" : "intestinal gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm].", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000640" + }, { + "val" : "FMA:15052" + }, { + "val" : "SCTID:266297002" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001015", - "lbl" : "musculature", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001016", - "lbl" : "nervous system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000344", + "lbl" : "mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP].", + "xrefs" : [ "Wikipedia:Mucous_membrane" ] + }, + "xrefs" : [ { + "val" : "AEO:0000199" + }, { + "val" : "BTO:0000886" + }, { + "val" : "CALOHA:TS-2031" + }, { + "val" : "EHDAA2_RETIRED:0003234" + }, { + "val" : "EV:0100382" + }, { + "val" : "FMA:85355" + }, { + "val" : "FMA:85358" + }, { + "val" : "GAID:297" + }, { + "val" : "MESH:D009092" + }, { + "val" : "NCIT:C13166" + }, { + "val" : "SCTID:361693009" + }, { + "val" : "Wikipedia:Mucous_membrane" + }, { + "val" : "galen:Mucosa" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001017", - "lbl" : "central nervous system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000353", + "lbl" : "parenchyma", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues.", + "xrefs" : [ "Wikipedia:Parenchyma" ] + }, + "xrefs" : [ { + "val" : "EHDAA:3015" + }, { + "val" : "EHDAA:3905" + }, { + "val" : "EHDAA:3999" + }, { + "val" : "EHDAA:4005" + }, { + "val" : "EHDAA:6899" + }, { + "val" : "EHDAA:6903" + }, { + "val" : "EHDAA:6994" + }, { + "val" : "EHDAA:8086" + }, { + "val" : "EHDAA:9182" + }, { + "val" : "EHDAA:9190" + }, { + "val" : "EHDAA:9196" + }, { + "val" : "EHDAA:9202" + }, { + "val" : "FMA:45732" + }, { + "val" : "NCIT:C74601" + }, { + "val" : "Wikipedia:Parenchyma" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001021", - "lbl" : "nerve", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000355", + "lbl" : "pharyngeal mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mucosa that is part of a pharynx [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001047" + }, { + "val" : "EMAPA:26957" + }, { + "val" : "FMA:55031" + }, { + "val" : "MA:0003143" + }, { + "val" : "SCTID:362121003" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001027", - "lbl" : "sensory nerve", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001032", - "lbl" : "sensory system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001040", - "lbl" : "yolk sac", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001041", - "lbl" : "foregut", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001042", - "lbl" : "chordate pharynx", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001043", - "lbl" : "esophagus", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000358", + "lbl" : "blastocyst", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO].", + "xrefs" : [ "GO:0001824", "Wikipedia:Blastocyst" ] + }, + "xrefs" : [ { + "val" : "BTO:0001099" + }, { + "val" : "CALOHA:TS-0076" + }, { + "val" : "EFO:0000295" + }, { + "val" : "EMAPA:36035" + }, { + "val" : "EV:0100394" + }, { + "val" : "FMA:83041" + }, { + "val" : "GAID:1153" + }, { + "val" : "MESH:D001755" + }, { + "val" : "NCIT:C13739" + }, { + "val" : "SCTID:308837009" + }, { + "val" : "Wikipedia:Blastocyst" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001048", - "lbl" : "primordium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001049", - "lbl" : "neural tube", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001062", - "lbl" : "anatomical entity", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000361", + "lbl" : "red bone marrow", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/red+marrow" ] + }, + "xrefs" : [ { + "val" : "BTO:0001160" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:74595" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "SCTID:328538003" + }, { + "val" : "SCTID:75330005" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001068", - "lbl" : "skin of back", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001070", - "lbl" : "external carotid artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000371", + "lbl" : "syncytiotrophoblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated).", + "xrefs" : [ "Wikipedia:Syncytiotrophoblast", "http://embryology.med.unsw.edu.au/Notes/placenta5.htm" ] + }, + "xrefs" : [ { + "val" : "BTO:0001335" + }, { + "val" : "EHDAA:129" + }, { + "val" : "EHDAA:91" + }, { + "val" : "EMAPA:16068" + }, { + "val" : "FMA:83040" + }, { + "val" : "NCIT:C33918" + }, { + "val" : "SCTID:256965005" + }, { + "val" : "Wikipedia:Syncytiotrophoblast" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001071", - "lbl" : "superficial cervical artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000377", + "lbl" : "maxillary nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses.", + "xrefs" : [ "MP:0009799", "Wikipedia:Maxillary_nerve" ] + }, + "xrefs" : [ { + "val" : "AAO:0010670" + }, { + "val" : "BTO:0001378" + }, { + "val" : "EHDAA2:0002087" + }, { + "val" : "EMAPA:17799" + }, { + "val" : "FMA:52724" + }, { + "val" : "GAID:836" + }, { + "val" : "MA:0001103" + }, { + "val" : "MESH:D008442" + }, { + "val" : "SCTID:280211001" + }, { + "val" : "VHOG:0001346" + }, { + "val" : "Wikipedia:Maxillary_nerve" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001072", - "lbl" : "inferior vena cava", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000379", + "lbl" : "tracheal mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mucosa that is part of a respiratory airway.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001390" + }, { + "val" : "FMA:7471" + }, { + "val" : "SCTID:660006" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001074", - "lbl" : "pericardial cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001081", - "lbl" : "endocardium of ventricle", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001082", - "lbl" : "epicardium of ventricle", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001083", - "lbl" : "myocardium of ventricle", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001084", - "lbl" : "skin of head", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001085", - "lbl" : "skin of trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001087", - "lbl" : "pleural fluid", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001090", - "lbl" : "synovial fluid", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001096", - "lbl" : "wall of esophagus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001103", - "lbl" : "diaphragm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001133", - "lbl" : "cardiac muscle tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001134", - "lbl" : "skeletal muscle tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001135", - "lbl" : "smooth muscle tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001136", - "lbl" : "mesothelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001137", - "lbl" : "dorsum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001145", - "lbl" : "ovarian vein", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001167", - "lbl" : "wall of stomach", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001178", - "lbl" : "visceral peritoneum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001179", - "lbl" : "peritoneal cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001190", - "lbl" : "ovarian artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000383", + "lbl" : "musculature of body", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified].", + "xrefs" : [ "VSAO:0000033" ] + }, + "xrefs" : [ { + "val" : "AAO:0000307" + }, { + "val" : "BILA:0000088" + }, { + "val" : "BTO:0001369" + }, { + "val" : "BTO:0001485" + }, { + "val" : "EFO:0000801" + }, { + "val" : "FMA:72954" + }, { + "val" : "MA:0002888" + }, { + "val" : "MAT:0000025" + }, { + "val" : "MIAA:0000025" + }, { + "val" : "VSAO:0000033" + }, { + "val" : "XAO:0004042" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001199", - "lbl" : "mucosa of stomach", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001200", - "lbl" : "submucosa of stomach", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001201", - "lbl" : "serosa of stomach", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001268", - "lbl" : "peritoneal fluid", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001276", - "lbl" : "epithelium of stomach", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001366", - "lbl" : "parietal peritoneum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001416", - "lbl" : "skin of abdomen", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001417", - "lbl" : "skin of neck", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001418", - "lbl" : "skin of thorax", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001421", - "lbl" : "pectoral girdle region", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001434", - "lbl" : "skeletal system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001444", - "lbl" : "subdivision of head", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001456", - "lbl" : "face", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001458", - "lbl" : "skin of lip", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001474", - "lbl" : "bone element", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001484", - "lbl" : "articular capsule", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001496", - "lbl" : "ascending aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000389", + "lbl" : "lens cortex", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Tissue that surrounds the lens nucleus.", + "xrefs" : [ "http://www.thefreedictionary.com/lens+cortex" ] + }, + "xrefs" : [ { + "val" : "BTO:0001632" + }, { + "val" : "CALOHA:TS-0542" + }, { + "val" : "FMA:58970" + }, { + "val" : "MESH:D007904" + }, { + "val" : "SCTID:280626006" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001508", - "lbl" : "arch of aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000390", + "lbl" : "lens nucleus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The core of the crystalline lens, surrounded by the cortex.", + "xrefs" : [ "BTO:0001633" ] + }, + "xrefs" : [ { + "val" : "BTO:0001633" + }, { + "val" : "FMA:58971" + }, { + "val" : "MESH:D007907" + }, { + "val" : "SCTID:280628007" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001514", - "lbl" : "descending aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000397", + "lbl" : "colonic epithelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelium that is part of a colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001709" + }, { + "val" : "CALOHA:TS-0163" + }, { + "val" : "EMAPA:18941" + }, { + "val" : "FMA:17302" + }, { + "val" : "MA:0003195" + }, { + "val" : "SCTID:42978003" + }, { + "val" : "TAO:0005128" + }, { + "val" : "ZFA:0005128" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001515", - "lbl" : "thoracic aorta", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001516", - "lbl" : "abdominal aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000409", + "lbl" : "serous gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland in which the principal secretory cells are serous secreting cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ] + }, + "xrefs" : [ { + "val" : "BTO:0001837" + }, { + "val" : "FMA:62889" + }, { + "val" : "Wikipedia:Serous_gland" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001529", - "lbl" : "brachiocephalic artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000410", + "lbl" : "bronchial mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mucosa that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001846" + }, { + "val" : "FMA:62652" + }, { + "val" : "SCTID:30802009" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001530", - "lbl" : "common carotid artery plus branches", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "lbl" : "mucous gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland in which the principal secretory cells are mucus secreting cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ] + }, + "xrefs" : [ { + "val" : "AAO:0010601" + }, { + "val" : "BTO:0001979" + }, { + "val" : "FMA:62888" + }, { + "val" : "Wikipedia:Mucous_gland" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001533", - "lbl" : "subclavian artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000415", + "lbl" : "artery wall", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An anatomical wall that is part of an artery [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002009" + }, { + "val" : "FMA:14155" + }, { + "val" : "galen:ArterialWall" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001534", - "lbl" : "right subclavian artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000440", + "lbl" : "trabecula", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP].", + "xrefs" : [ "GO:0060343", "Wikipedia:Trabecula" ] + }, + "xrefs" : [ { + "val" : "BTO:0002501" + }, { + "val" : "FMA:85273" + }, { + "val" : "Wikipedia:Trabecula" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001555", - "lbl" : "digestive tract", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000456", + "lbl" : "secretion of exocrine gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of organism substance that is produced by exocrine glands.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0001005" + }, { + "val" : "BTO:0002977" + }, { + "val" : "BTO:0002979" + }, { + "val" : "EMAPA:36535" + }, { + "val" : "FMA:9675" + }, { + "val" : "MA:0002504" + }, { + "val" : "MESH:D012634" + }, { + "val" : "NCIT:C34062" + }, { + "val" : "galen:Secretion" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001558", - "lbl" : "lower respiratory tract", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000463", + "lbl" : "organism substance", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010839" + }, { + "val" : "AEO:0000004" + }, { + "val" : "BILA:0000004" + }, { + "val" : "CALOHA:TS-2101" + }, { + "val" : "CARO:0000004" + }, { + "val" : "EHDAA2:0003004" + }, { + "val" : "EMAPA:35178" + }, { + "val" : "FMA:9669" + }, { + "val" : "HAO:0000004" + }, { + "val" : "MA:0002450" + }, { + "val" : "NCIT:C13236" + }, { + "val" : "SPD:0000008" + }, { + "val" : "TAO:0001487" + }, { + "val" : "TGMA:0001824" + }, { + "val" : "VHOG:0001726" + }, { + "val" : "XAO:0004001" + }, { + "val" : "ZFA:0001487" + }, { + "val" : "galen:BodySubstance" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001584", - "lbl" : "left subclavian artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000464", + "lbl" : "anatomical space", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] - } - }, { + "definition" : { + "val" : "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010110" + }, { + "val" : "AEO:0000005" + }, { + "val" : "BILA:0000005" + }, { + "val" : "CARO:0000005" + }, { + "val" : "EHDAA2:0003005" + }, { + "val" : "FMA:5897" + }, { + "val" : "HAO:0000005" + }, { + "val" : "NCIT:C94478" + }, { + "val" : "TAO:0001668" + }, { + "val" : "TGMA:0001825" + }, { + "val" : "VHOG:0001728" + }, { + "val" : "XAO:0003190" + }, { + "val" : "ZFA:0001643" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000465", + "lbl" : "material anatomical entity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical entity that has mass.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010264" + }, { + "val" : "AEO:0000006" + }, { + "val" : "BILA:0000006" + }, { + "val" : "CARO:0000006" + }, { + "val" : "EHDAA2:0003006" + }, { + "val" : "FMA:67165" + }, { + "val" : "HAO:0000006" + }, { + "val" : "TAO:0001836" + }, { + "val" : "TGMA:0001826" + }, { + "val" : "VHOG:0001721" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000466", + "lbl" : "immaterial anatomical entity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical entity that has no mass.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010265" + }, { + "val" : "AEO:0000007" + }, { + "val" : "BILA:0000007" + }, { + "val" : "CARO:0000007" + }, { + "val" : "EHDAA2:0003007" + }, { + "val" : "FMA:67112" + }, { + "val" : "HAO:0000007" + }, { + "val" : "TAO:0001835" + }, { + "val" : "TGMA:0001827" + }, { + "val" : "VHOG:0001727" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000467", + "lbl" : "anatomical system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.", + "xrefs" : [ "CARO:0000011" ] + }, + "xrefs" : [ { + "val" : "AAO:0000007" + }, { + "val" : "AEO:0000011" + }, { + "val" : "BILA:0000011" + }, { + "val" : "BIRNLEX:14" + }, { + "val" : "BSA:0000049" + }, { + "val" : "CALOHA:TS-2088" + }, { + "val" : "CARO:0000011" + }, { + "val" : "EHDAA2:0003011" + }, { + "val" : "EHDAA:392" + }, { + "val" : "EMAPA:16103" + }, { + "val" : "EV:0100000" + }, { + "val" : "FMA:7149" + }, { + "val" : "HAO:0000011" + }, { + "val" : "MA:0000003" + }, { + "val" : "NCIT:C12919" + }, { + "val" : "SCTID:278195005" + }, { + "val" : "TAO:0001439" + }, { + "val" : "TGMA:0001831" + }, { + "val" : "VHOG:0001725" + }, { + "val" : "WBbt:0005746" + }, { + "val" : "WBbt:0005763" + }, { + "val" : "Wikipedia:Organ_system" + }, { + "val" : "XAO:0003002" + }, { + "val" : "ZFA:0001439" + }, { + "val" : "galen:AnatomicalSystem" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000468", + "lbl" : "multicellular organism", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that is an individual member of a species and consists of more than one cell.", + "xrefs" : [ "CARO:0000012", "Wikipedia:Multi-cellular_organism", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010026" + }, { + "val" : "AEO:0000191" + }, { + "val" : "BILA:0000012" + }, { + "val" : "BIRNLEX:18" + }, { + "val" : "BSA:0000038" + }, { + "val" : "BTO:0000042" + }, { + "val" : "CARO:0000012" + }, { + "val" : "EFO:0002906" + }, { + "val" : "EHDAA2:0003103" + }, { + "val" : "EHDAA2:0003191" + }, { + "val" : "EHDAA:1" + }, { + "val" : "EMAPA:25765" + }, { + "val" : "EV:0100016" + }, { + "val" : "FMA:256135" + }, { + "val" : "HAO:0000012" + }, { + "val" : "NCIT:C13041" + }, { + "val" : "SCTID:243928005" + }, { + "val" : "TADS:0000001" + }, { + "val" : "TAO:0001094" + }, { + "val" : "TGMA:0001832" + }, { + "val" : "VHOG:0000671" + }, { + "val" : "WBbt:0007833" + }, { + "val" : "Wikipedia:Multi-cellular_organism" + }, { + "val" : "XAO:0003004" + }, { + "val" : "ZFA:0001094" + }, { + "val" : "galen:Organism" + }, { + "val" : "ncithesaurus:Whole_Organism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000471", + "lbl" : "compound organ component", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that is part of a compound organ.", + "xrefs" : [ "CARO:0000019", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010017" + }, { + "val" : "AEO:0000019" + }, { + "val" : "BILA:0000019" + }, { + "val" : "CARO:0000019" + }, { + "val" : "EHDAA2:0003019" + }, { + "val" : "HAO:0000019" + }, { + "val" : "TAO:0001489" + }, { + "val" : "TGMA:0001835" + }, { + "val" : "XAO:0003039" + }, { + "val" : "ZFA:0001489" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000474", + "lbl" : "female reproductive system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The organs and associated structures associated with bearing offspring in a female animal.", + "xrefs" : [ "MP:0001119", "Wikipedia:Female_genitalia", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000083" + }, { + "val" : "CALOHA:TS-1303" + }, { + "val" : "EFO:0000969" + }, { + "val" : "EHDAA2:0000506" + }, { + "val" : "EHDAA:8116" + }, { + "val" : "EMAPA:17959" + }, { + "val" : "EV:0100110" + }, { + "val" : "FMA:45663" + }, { + "val" : "GAID:364" + }, { + "val" : "HAO:0000324" + }, { + "val" : "MA:0000381" + }, { + "val" : "MESH:D005836" + }, { + "val" : "MIAA:0000028" + }, { + "val" : "NCIT:C12402" + }, { + "val" : "SCTID:361386004" + }, { + "val" : "TGMA:0000635" + }, { + "val" : "VHOG:0000726" + }, { + "val" : "Wikipedia:Female_genitalia" + }, { + "val" : "WikipediaCategory:Female_reproductive_system" + }, { + "val" : "XAO:0000156" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000475", + "lbl" : "organism subdivision", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument.", + "xrefs" : [ "CARO:0000032", "CARO:DOS", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010053" + }, { + "val" : "AEO:0000032" + }, { + "val" : "BILA:0000032" + }, { + "val" : "BIRNLEX:7" + }, { + "val" : "CALOHA:TS-2084" + }, { + "val" : "CARO:0000032" + }, { + "val" : "EFO:0000808" + }, { + "val" : "EHDAA2:0003032" + }, { + "val" : "EMAPA:36031" + }, { + "val" : "FMA:7153" + }, { + "val" : "HAO:0000032" + }, { + "val" : "MA:0002433" + }, { + "val" : "MAT:0000293" + }, { + "val" : "MESH:D001829" + }, { + "val" : "MIAA:0000293" + }, { + "val" : "NCIT:C32221" + }, { + "val" : "TAO:0001308" + }, { + "val" : "TGMA:0001840" + }, { + "val" : "VHOG:0001758" + }, { + "val" : "Wikipedia:Body_part" + }, { + "val" : "XAO:0003013" + }, { + "val" : "ZFA:0001308" + }, { + "val" : "galen:BodyPart" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000476", + "lbl" : "acellular anatomical structure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010268" + }, { + "val" : "AEO:0000040" + }, { + "val" : "BILA:0000040" + }, { + "val" : "CARO:0000040" + }, { + "val" : "EHDAA2:0003040" + }, { + "val" : "FMA:63863" + }, { + "val" : "HAO:0000040" + }, { + "val" : "TAO:0000382" + }, { + "val" : "TGMA:0001841" + }, { + "val" : "XAO:0003162" + }, { + "val" : "ZFA:0000382" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000477", + "lbl" : "anatomical cluster", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical group whose component anatomical structures lie in close proximity to each other.", + "xrefs" : [ "FBbt:00007277" ] + }, + "xrefs" : [ { + "val" : "VHOG:0001737" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000478", + "lbl" : "extraembryonic structure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis.", + "xrefs" : [ "CARO:DOS", "http://orcid.org/0000-0001-9114-8737", "https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279" ] + }, + "comments" : [ "see also conceptus extraembryonic component in EHDAA2." ], + "xrefs" : [ { + "val" : "AAO:0010020" + }, { + "val" : "AEO:0000042" + }, { + "val" : "BILA:0000042" + }, { + "val" : "CALOHA:TS-2119" + }, { + "val" : "CARO:0000042" + }, { + "val" : "EHDAA2:0003042" + }, { + "val" : "EHDAA:46" + }, { + "val" : "FMA:85537" + }, { + "val" : "HAO:0000042" + }, { + "val" : "NCIT:C34055" + }, { + "val" : "SCTID:314908006" + }, { + "val" : "TAO:0000020" + }, { + "val" : "TGMA:0001843" + }, { + "val" : "VHOG:0000292" + }, { + "val" : "XAO:0004005" + }, { + "val" : "ZFA:0000020" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000479", + "lbl" : "tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation.", + "xrefs" : [ "CARO:0000043" ] + }, + "xrefs" : [ { + "val" : "AAO:0000607" + }, { + "val" : "AAO:0010054" + }, { + "val" : "AEO:0000043" + }, { + "val" : "BILA:0000043" + }, { + "val" : "BIRNLEX:19" + }, { + "val" : "CALOHA:TS-2090" + }, { + "val" : "CARO:0000043" + }, { + "val" : "EHDAA2:0003043" + }, { + "val" : "EMAPA:35868" + }, { + "val" : "FMA:9637" + }, { + "val" : "HAO:0000043" + }, { + "val" : "MA:0003002" + }, { + "val" : "MESH:D014024" + }, { + "val" : "NCIT:C12801" + }, { + "val" : "TAO:0001477" + }, { + "val" : "TGMA:0001844" + }, { + "val" : "VHOG:0001757" + }, { + "val" : "WBbt:0005729" + }, { + "val" : "XAO:0003040" + }, { + "val" : "ZFA:0001477" + }, { + "val" : "galen:Tissue" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000481", + "lbl" : "multi-tissue structure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types.", + "xrefs" : [ "CARO:0000055", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010048" + }, { + "val" : "AEO:0000055" + }, { + "val" : "BILA:0000055" + }, { + "val" : "CARO:0000055" + }, { + "val" : "EHDAA2:0003055" + }, { + "val" : "HAO:0000055" + }, { + "val" : "TAO:0001488" + }, { + "val" : "TGMA:0001847" + }, { + "val" : "VHOG:0001762" + }, { + "val" : "XAO:0003037" + }, { + "val" : "ZFA:0001488" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000483", + "lbl" : "epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO].", + "xrefs" : [ "Wikipedia:Epithelium", "http://orcid.org/0000-0001-9114-8737" ] + }, + "comments" : [ "Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it?" ], + "xrefs" : [ { + "val" : "AAO:0000144" + }, { + "val" : "AAO:0010055" + }, { + "val" : "AEO:0000066" + }, { + "val" : "BILA:0000066" + }, { + "val" : "BTO:0000416" + }, { + "val" : "CALOHA:TS-0288" + }, { + "val" : "CARO:0000066" + }, { + "val" : "EHDAA2:0003066" + }, { + "val" : "EMAPA:32738" + }, { + "val" : "FMA:9639" + }, { + "val" : "GAID:402" + }, { + "val" : "HAO:0000066" + }, { + "val" : "MA:0003060" + }, { + "val" : "MESH:D004848" + }, { + "val" : "NCIT:C12710" + }, { + "val" : "SCTID:31610004" + }, { + "val" : "TAO:0001486" + }, { + "val" : "VHOG:0000387" + }, { + "val" : "Wikipedia:Epithelium" + }, { + "val" : "XAO:0003045" + }, { + "val" : "ZFA:0001486" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000484", + "lbl" : "simple cuboidal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Unilaminar epithelium that consists of a single layer of cuboidal cells.", + "xrefs" : [ "Wikipedia:Simple_cuboidal_epithelium", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010064" + }, { + "val" : "AEO:0000067" + }, { + "val" : "BILA:0000067" + }, { + "val" : "CARO:0000067" + }, { + "val" : "EHDAA2:0003067" + }, { + "val" : "FMA:45566" + }, { + "val" : "HAO:0000067" + }, { + "val" : "NCIT:C33553" + }, { + "val" : "TAO:0001497" + }, { + "val" : "Wikipedia:Simple_cuboidal_epithelium" + }, { + "val" : "XAO:0004009" + }, { + "val" : "ZFA:0001497" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000485", + "lbl" : "simple columnar epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA].", + "xrefs" : [ "FMA:FMA", "Wikipedia:Simple_columnar_epithelium", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010063" + }, { + "val" : "AEO:0000068" + }, { + "val" : "BILA:0000068" + }, { + "val" : "CARO:0000068" + }, { + "val" : "EHDAA2_RETIRED:0003068" + }, { + "val" : "FMA:45567" + }, { + "val" : "HAO:0000068" + }, { + "val" : "NCIT:C33552" + }, { + "val" : "SCTID:32210007" + }, { + "val" : "TAO:0001496" + }, { + "val" : "Wikipedia:Simple_columnar_epithelium" + }, { + "val" : "XAO:0004008" + }, { + "val" : "ZFA:0001496" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000486", + "lbl" : "multilaminar epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA].", + "xrefs" : [ "FMA:FMA", "Wikipedia:Stratified_epithelium", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010059" + }, { + "val" : "AEO:0000069" + }, { + "val" : "BILA:0000069" + }, { + "val" : "BTO:0002074" + }, { + "val" : "CARO:0000069" + }, { + "val" : "EHDAA2:0003069" + }, { + "val" : "FMA:45562" + }, { + "val" : "HAO:0000069" + }, { + "val" : "NCIT:C33622" + }, { + "val" : "SCTID:309044005" + }, { + "val" : "TAO:0001494" + }, { + "val" : "Wikipedia:Stratified_epithelium" + }, { + "val" : "XAO:0004006" + }, { + "val" : "ZFA:0001494" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000487", + "lbl" : "simple squamous epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA].", + "xrefs" : [ "FMA:45565", "Wikipedia:Simple_squamous_epithelium", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010066" + }, { + "val" : "AEO:0000070" + }, { + "val" : "BILA:0000070" + }, { + "val" : "BTO:0002073" + }, { + "val" : "CARO:0000070" + }, { + "val" : "EHDAA2:0003070" + }, { + "val" : "FMA:45565" + }, { + "val" : "HAO:0000070" + }, { + "val" : "NCIT:C13178" + }, { + "val" : "TAO:0001498" + }, { + "val" : "Wikipedia:Simple_squamous_epithelium" + }, { + "val" : "XAO:0004010" + }, { + "val" : "ZFA:0001498" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000488", + "lbl" : "atypical epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium that consists of epithelial cells not arranged in one ore more layers.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010057" + }, { + "val" : "AEO:0000071" + }, { + "val" : "BILA:0000071" + }, { + "val" : "CARO:0000071" + }, { + "val" : "EHDAA2:0003071" + }, { + "val" : "FMA:61741" + }, { + "val" : "HAO:0000071" + }, { + "val" : "TAO:0001493" + }, { + "val" : "XAO:0004004" + }, { + "val" : "ZFA:0001493" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000489", + "lbl" : "cavitated compound organ", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Compound organ that contains one or more macroscopic anatomical spaces.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010016" + }, { + "val" : "AEO:0000072" + }, { + "val" : "BILA:0000072" + }, { + "val" : "CARO:0000072" + }, { + "val" : "EHDAA2:0003072" + }, { + "val" : "FMA:55671" + }, { + "val" : "HAO:0000072" + }, { + "val" : "TAO:0001490" + }, { + "val" : "TGMA:0001857" + }, { + "val" : "VHOG:0001730" + }, { + "val" : "XAO:0003165" + }, { + "val" : "ZFA:0001490" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000490", + "lbl" : "unilaminar epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA].", + "xrefs" : [ "FMA:45561", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010062" + }, { + "val" : "AEO:0000073" + }, { + "val" : "BILA:0000073" + }, { + "val" : "BTO:0002073" + }, { + "val" : "CARO:0000073" + }, { + "val" : "EHDAA2:0003073" + }, { + "val" : "FMA:45561" + }, { + "val" : "HAO:0000073" + }, { + "val" : "NCIT:C33554" + }, { + "val" : "SCTID:309043004" + }, { + "val" : "TAO:0001495" + }, { + "val" : "XAO:0004007" + }, { + "val" : "ZFA:0001495" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "lbl" : "mucus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water.", + "xrefs" : [ "Wikipedia:Mucus" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2144" + }, { + "val" : "ENVO:02000040" + }, { + "val" : "FMA:66938" + }, { + "val" : "GAID:1164" + }, { + "val" : "MESH:D009093" + }, { + "val" : "NCIT:C13259" + }, { + "val" : "Wikipedia:Mucus" + }, { + "val" : "galen:Mucus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000915", + "lbl" : "thoracic segment of trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of trunk that lies between the head and the abdomen.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35862" + }, { + "val" : "FMA:259209" + }, { + "val" : "MA:0000022" + }, { + "val" : "SCTID:302551006" + }, { + "val" : "Wikipedia:Thorax" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000916", + "lbl" : "abdomen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000020" + }, { + "val" : "CALOHA:TS-0001" + }, { + "val" : "EFO:0000968" + }, { + "val" : "EMAPA:35102" + }, { + "val" : "EV:0100011" + }, { + "val" : "FMA:9577" + }, { + "val" : "GAID:16" + }, { + "val" : "MA:0000029" + }, { + "val" : "MAT:0000298" + }, { + "val" : "MESH:D000005" + }, { + "val" : "MIAA:0000298" + }, { + "val" : "SCTID:302553009" + }, { + "val" : "Wikipedia:Abdomen" + }, { + "val" : "galen:Abdomen" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000922", + "lbl" : "embryo", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.", + "xrefs" : [ "BTO:0000379", "FB:FBrf0039741", "FB:FBrf0041814", "GO:0009790", "Wikipedia:Embryo" ] + }, + "xrefs" : [ { + "val" : "AAO:0011035" + }, { + "val" : "AEO:0000169" + }, { + "val" : "BILA:0000056" + }, { + "val" : "BSA:0000039" + }, { + "val" : "BTO:0000379" + }, { + "val" : "CALOHA:TS-0229" + }, { + "val" : "EFO:0001367" + }, { + "val" : "EHDAA2:0000002" + }, { + "val" : "EHDAA2_RETIRED:0003236" + }, { + "val" : "EHDAA:38" + }, { + "val" : "EMAPA:16039" + }, { + "val" : "FMA:69068" + }, { + "val" : "GAID:963" + }, { + "val" : "MAT:0000226" + }, { + "val" : "MESH:D004622" + }, { + "val" : "MIAA:0000019" + }, { + "val" : "NCIT:C28147" + }, { + "val" : "OGEM:000001" + }, { + "val" : "SCTID:57991002" + }, { + "val" : "VHOG:0001766" + }, { + "val" : "Wikipedia:Embryo" + }, { + "val" : "XAO:0000113" + }, { + "val" : "ZFA:0000103" + }, { + "val" : "http://neurolex.org/wiki/Category:Embryonic_organism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000923", + "lbl" : "germ layer", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm.", + "xrefs" : [ "Wikipedia:Germ_layer", "https://github.com/obophenotype/uberon/issues/203" ] + }, + "comments" : [ "Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest]" ], + "xrefs" : [ { + "val" : "AAO:0000480" + }, { + "val" : "BILA:0000035" + }, { + "val" : "BTO:0000556" + }, { + "val" : "EMAPA:36033" + }, { + "val" : "FMA:69069" + }, { + "val" : "GAID:1303" + }, { + "val" : "MESH:D005855" + }, { + "val" : "NCIT:C12950" + }, { + "val" : "NCIT:C54105" + }, { + "val" : "TAO:0001122" + }, { + "val" : "VHOG:0001223" + }, { + "val" : "Wikipedia:Germ_layer" + }, { + "val" : "XAO:0003011" + }, { + "val" : "ZFA:0001122" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000924", + "lbl" : "ectoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.", + "xrefs" : [ "Wikipedia:Ectoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0000137" + }, { + "val" : "BILA:0000036" + }, { + "val" : "BTO:0000315" + }, { + "val" : "CALOHA:TS-0216" + }, { + "val" : "EFO:0000414" + }, { + "val" : "EHDAA2:0000428" + }, { + "val" : "EMAPA:16069" + }, { + "val" : "EV:0100003" + }, { + "val" : "FMA:69070" + }, { + "val" : "GAID:1304" + }, { + "val" : "MAT:0000155" + }, { + "val" : "MAT:0000173" + }, { + "val" : "MESH:D004475" + }, { + "val" : "MIAA:0000173" + }, { + "val" : "NCIT:C12703" + }, { + "val" : "SCTID:362851007" + }, { + "val" : "TAO:0000016" + }, { + "val" : "VHOG:0000153" + }, { + "val" : "Wikipedia:Ectoderm" + }, { + "val" : "XAO:0000001" + }, { + "val" : "ZFA:0000016" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000925", + "lbl" : "endoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.", + "xrefs" : [ "Wikipedia:Endoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0000139" + }, { + "val" : "BILA:0000038" + }, { + "val" : "BTO:0000800" + }, { + "val" : "CALOHA:TS-0273" + }, { + "val" : "EFO:0002545" + }, { + "val" : "EHDAA2:0000436" + }, { + "val" : "EMAPA:16062" + }, { + "val" : "EV:0100005" + }, { + "val" : "FMA:69071" + }, { + "val" : "GAID:1305" + }, { + "val" : "MAT:0000175" + }, { + "val" : "MESH:D004707" + }, { + "val" : "MIAA:0000175" + }, { + "val" : "NCIT:C12706" + }, { + "val" : "SCTID:362855003" + }, { + "val" : "TAO:0000017" + }, { + "val" : "VHOG:0000154" + }, { + "val" : "Wikipedia:Endoderm" + }, { + "val" : "XAO:0000090" + }, { + "val" : "ZFA:0000017" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000926", + "lbl" : "mesoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The middle germ layer of the embryo, between the endoderm and ectoderm.", + "xrefs" : [ "Wikipedia:Mesoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0000304" + }, { + "val" : "BILA:0000037" + }, { + "val" : "BTO:0000839" + }, { + "val" : "CALOHA:TS-0623" + }, { + "val" : "EFO:0001981" + }, { + "val" : "EHDAA2:0001128" + }, { + "val" : "EHDAA:124" + }, { + "val" : "EHDAA:160" + }, { + "val" : "EHDAA:183" + }, { + "val" : "EMAPA:16083" + }, { + "val" : "EV:0100006" + }, { + "val" : "FMA:69072" + }, { + "val" : "GAID:522" + }, { + "val" : "MAT:0000174" + }, { + "val" : "MESH:D008648" + }, { + "val" : "MIAA:0000174" + }, { + "val" : "NCIT:C12750" + }, { + "val" : "SCTID:362854004" + }, { + "val" : "TAO:0000041" + }, { + "val" : "VHOG:0000152" + }, { + "val" : "Wikipedia:Mesoderm" + }, { + "val" : "XAO:0000050" + }, { + "val" : "ZFA:0000041" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000930", + "lbl" : "stomodeum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity.", + "xrefs" : [ "Wikipedia:Stomodeum", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/326" ] + }, + "xrefs" : [ { + "val" : "BTO:0004224" + }, { + "val" : "EHDAA2:0001929" + }, { + "val" : "EMAPA:16263" + }, { + "val" : "FMA:295846" + }, { + "val" : "NCIT:C34306" + }, { + "val" : "TAO:0001290" + }, { + "val" : "TGMA:0000135" + }, { + "val" : "Wikipedia:Stomodeum" + }, { + "val" : "XAO:0000269" + }, { + "val" : "ZFA:0001290" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "lbl" : "proctodeum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract.", + "xrefs" : [ "ZFA:0000066", "https://github.com/obophenotype/uberon/issues/685", "https://sourceforge.net/p/fbbtdv/tickets/52" ] + }, + "xrefs" : [ { + "val" : "AAO:0011087" + }, { + "val" : "EHDAA2:0000121" + }, { + "val" : "EMAPA:25038" + }, { + "val" : "NCIT:C34278" + }, { + "val" : "TAO:0000066" + }, { + "val" : "VHOG:0000139" + }, { + "val" : "Wikipedia:Proctodeum" + }, { + "val" : "XAO:0001019" + }, { + "val" : "ZFA:0000066" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000945", + "lbl" : "stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Stomach", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000579" + }, { + "val" : "ANISEED:1235297" + }, { + "val" : "BTO:0001307" + }, { + "val" : "CALOHA:TS-0980" + }, { + "val" : "EFO:0000837" + }, { + "val" : "EHDAA2:0001915" + }, { + "val" : "EHDAA:2993" + }, { + "val" : "EMAPA:17021" + }, { + "val" : "EV:0100070" + }, { + "val" : "FMA:7148" + }, { + "val" : "GAID:293" + }, { + "val" : "MA:0000353" + }, { + "val" : "MAT:0000051" + }, { + "val" : "MESH:D013270" + }, { + "val" : "MIAA:0000051" + }, { + "val" : "NCIT:C12391" + }, { + "val" : "SCTID:181246003" + }, { + "val" : "TAO:0002121" + }, { + "val" : "VHOG:0000408" + }, { + "val" : "Wikipedia:Stomach" + }, { + "val" : "XAO:0000128" + }, { + "val" : "galen:Stomach" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000947", + "lbl" : "aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation.", + "xrefs" : [ "ISBN:0-683-40008-8", "MESH:A07.231.114.056", "MP:0000272", "Wikipedia:Aorta", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010213" + }, { + "val" : "BTO:0000135" + }, { + "val" : "CALOHA:TS-0046" + }, { + "val" : "EFO:0000265" + }, { + "val" : "EMAPA:18601" + }, { + "val" : "EV:0100027" + }, { + "val" : "FMA:3734" + }, { + "val" : "GAID:469" + }, { + "val" : "MA:0000062" + }, { + "val" : "MAT:0000035" + }, { + "val" : "MESH:D001011" + }, { + "val" : "MIAA:0000035" + }, { + "val" : "NCIT:C12669" + }, { + "val" : "SCTID:181298001" + }, { + "val" : "VHOG:0001523" + }, { + "val" : "Wikipedia:Aorta" + }, { + "val" : "XAO:0003010" + }, { + "val" : "galen:Aorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000948", + "lbl" : "heart", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ.", + "xrefs" : [ "Wikipedia:Heart", "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Taxon notes:\" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)\" DOI:10.1101/gad.1485706" ], + "xrefs" : [ { + "val" : "AAO:0010210" + }, { + "val" : "BILA:0000020" + }, { + "val" : "BTO:0000562" + }, { + "val" : "CALOHA:TS-0445" + }, { + "val" : "EFO:0000815" + }, { + "val" : "EHDAA2:0000738" + }, { + "val" : "EHDAA:420" + }, { + "val" : "EMAPA:16105" + }, { + "val" : "EV:0100018" + }, { + "val" : "FMA:7088" + }, { + "val" : "GAID:174" + }, { + "val" : "MA:0000072" + }, { + "val" : "MAT:0000036" + }, { + "val" : "MESH:D006321" + }, { + "val" : "MIAA:0000036" + }, { + "val" : "NCIT:C12727" + }, { + "val" : "SCTID:302509004" + }, { + "val" : "TAO:0000114" + }, { + "val" : "VHOG:0000276" + }, { + "val" : "Wikipedia:Heart" + }, { + "val" : "XAO:0000064" + }, { + "val" : "ZFA:0000114" + }, { + "val" : "galen:Heart" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000949", + "lbl" : "endocrine system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.", + "xrefs" : [ "NLM:endocrine+system", "Wikipedia:Endocrine_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0010279" + }, { + "val" : "CALOHA:TS-1301" + }, { + "val" : "EFO:0002969" + }, { + "val" : "EHDAA2:0002224" + }, { + "val" : "EMAPA:35306" + }, { + "val" : "EV:0100128" + }, { + "val" : "FMA:9668" + }, { + "val" : "GAID:439" + }, { + "val" : "MA:0000012" + }, { + "val" : "MESH:D004703" + }, { + "val" : "NCIT:C12705" + }, { + "val" : "SCTID:278876000" + }, { + "val" : "TAO:0001158" + }, { + "val" : "VHOG:0000098" + }, { + "val" : "Wikipedia:Endocrine_system" + }, { + "val" : "XAO:0000158" + }, { + "val" : "ZFA:0001158" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000955", + "lbl" : "brain", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].", + "xrefs" : [ "Wikipedia:Brain", "https://github.com/obophenotype/uberon/issues/300" ] + }, + "xrefs" : [ { + "val" : "AAO:0010478" + }, { + "val" : "ABA:Brain" + }, { + "val" : "BAMS:Br" + }, { + "val" : "BAMS:Brain" + }, { + "val" : "BILA:0000135" + }, { + "val" : "BIRNLEX:796" + }, { + "val" : "BTO:0000142" + }, { + "val" : "CALOHA:TS-0095" + }, { + "val" : "DHBA:10155" + }, { + "val" : "EFO:0000302" + }, { + "val" : "EHDAA2:0000183" + }, { + "val" : "EHDAA:2641" + }, { + "val" : "EHDAA:6485" + }, { + "val" : "EMAPA:16894" + }, { + "val" : "EV:0100164" + }, { + "val" : "FMA:50801" + }, { + "val" : "GAID:571" + }, { + "val" : "HBA:4005" + }, { + "val" : "MA:0000168" + }, { + "val" : "MAT:0000098" + }, { + "val" : "MBA:8" + }, { + "val" : "MBA:997" + }, { + "val" : "MESH:D001921" + }, { + "val" : "MIAA:0000098" + }, { + "val" : "NCIT:C12439" + }, { + "val" : "PBA:3999" + }, { + "val" : "SCTID:258335003" + }, { + "val" : "TAO:0000008" + }, { + "val" : "VHOG:0000157" + }, { + "val" : "Wikipedia:Brain" + }, { + "val" : "XAO:0000010" + }, { + "val" : "ZFA:0000008" + }, { + "val" : "galen:Brain" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000957", + "lbl" : "lamina", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any thin layer or plate.", + "xrefs" : [ "Wikipedia:Lamina_of_the_vertebral_arch" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Lamina_of_the_vertebral_arch" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000962", + "lbl" : "nerve of cervical vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted].", + "xrefs" : [ "Wikipedia:Cervical_nerves" ] + }, + "comments" : [ "Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP]" ], + "xrefs" : [ { + "val" : "BAMS:cern" + }, { + "val" : "FMA:5859" + }, { + "val" : "NCIT:C32299" + }, { + "val" : "NLXANAT:20090207" + }, { + "val" : "SCTID:360497008" + }, { + "val" : "Wikipedia:Cervical_nerves" + }, { + "val" : "neuronames:2351" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000963", + "lbl" : "head sensillum", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "MAT:0000204" + }, { + "val" : "MIAA:0000204" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000964", + "lbl" : "cornea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure.", + "xrefs" : [ "ISBN:0-683-40008-8", "MESH:A09.371.060.217", "MP:0001312" ] + }, + "xrefs" : [ { + "val" : "AAO:0010344" + }, { + "val" : "BTO:0000286" + }, { + "val" : "CALOHA:TS-0171" + }, { + "val" : "EFO:0000377" + }, { + "val" : "EHDAA2:0000316" + }, { + "val" : "EHDAA:10199" + }, { + "val" : "EMAPA:17161" + }, { + "val" : "EV:0100341" + }, { + "val" : "FMA:58238" + }, { + "val" : "GAID:892" + }, { + "val" : "MA:0000266" + }, { + "val" : "MESH:D003315" + }, { + "val" : "NCIT:C12342" + }, { + "val" : "SCTID:181162001" + }, { + "val" : "TAO:0000640" + }, { + "val" : "VHOG:0000164" + }, { + "val" : "Wikipedia:Cornea" + }, { + "val" : "XAO:0000180" + }, { + "val" : "ZFA:0000640" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000965", + "lbl" : "lens of camera-type eye", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina.", + "xrefs" : [ "Wikipedia:Lens_(anatomy)", "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "The lens is avascular and nourished by diffusion from the aqueous and vitreous humors." ], + "xrefs" : [ { + "val" : "AAO:0010348" + }, { + "val" : "BTO:0000723" + }, { + "val" : "CALOHA:TS-0545" + }, { + "val" : "EHDAA:9057" + }, { + "val" : "EMAPA:17838" + }, { + "val" : "EV:0100343" + }, { + "val" : "FMA:58241" + }, { + "val" : "MA:0000275" + }, { + "val" : "MAT:0000141" + }, { + "val" : "MESH:D007908" + }, { + "val" : "MIAA:0000141" + }, { + "val" : "NCIT:C12743" + }, { + "val" : "RETIRED_EHDAA2:0000975" + }, { + "val" : "SCTID:181169005" + }, { + "val" : "TAO:0000035" + }, { + "val" : "VHOG:0000169" + }, { + "val" : "Wikipedia:Lens_(anatomy)" + }, { + "val" : "XAO:0000008" + }, { + "val" : "ZFA:0000035" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000966", + "lbl" : "retina", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.", + "xrefs" : [ "Wikipedia:Retina", "ZFIN:curator" ] + }, + "comments" : [ "Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods" ], + "xrefs" : [ { + "val" : "AAO:0010352" + }, { + "val" : "BAMS:R" + }, { + "val" : "BIRNLEX:1153" + }, { + "val" : "BTO:0001175" + }, { + "val" : "CALOHA:TS-0865" + }, { + "val" : "EFO:0000832" + }, { + "val" : "EHDAA2:0001627" + }, { + "val" : "EHDAA:4757" + }, { + "val" : "EMAPA:17168" + }, { + "val" : "EV:0100348" + }, { + "val" : "FMA:58301" + }, { + "val" : "GAID:755" + }, { + "val" : "MA:0000276" + }, { + "val" : "MAT:0000142" + }, { + "val" : "MBA:304325711" + }, { + "val" : "MESH:D012160" + }, { + "val" : "MIAA:0000142" + }, { + "val" : "NCIT:C12343" + }, { + "val" : "NIFSTD_RETIRED:birnlex_1156" + }, { + "val" : "SCTID:181171005" + }, { + "val" : "TAO:0000152" + }, { + "val" : "VHOG:0000229" + }, { + "val" : "Wikipedia:Retina" + }, { + "val" : "XAO:0000009" + }, { + "val" : "ZFA:0000152" + }, { + "val" : "neuronames:1862" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000970", + "lbl" : "eye", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that detects light.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BILA:0000017" + }, { + "val" : "BTO:0000439" + }, { + "val" : "CALOHA:TS-0309" + }, { + "val" : "EFO:0000827" + }, { + "val" : "EV:0100336" + }, { + "val" : "GAID:69" + }, { + "val" : "MAT:0000140" + }, { + "val" : "MESH:D005123" + }, { + "val" : "MIAA:0000140" + }, { + "val" : "Wikipedia:Eye" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000971", + "lbl" : "ommatidium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells.", + "xrefs" : [ "PMID:21062451" ] + }, + "xrefs" : [ { + "val" : "BTO:0001922" + }, { + "val" : "HAO:0000666" + }, { + "val" : "MAT:0000143" + }, { + "val" : "MIAA:0000143" + }, { + "val" : "Wikipedia:Ommatidium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000974", + "lbl" : "neck", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0000108" + }, { + "val" : "BTO:0000420" + }, { + "val" : "CALOHA:TS-2045" + }, { + "val" : "EFO:0000967" + }, { + "val" : "EHDAA2:0003108" + }, { + "val" : "EMAPA:35587" + }, { + "val" : "FMA:7155" + }, { + "val" : "GAID:86" + }, { + "val" : "MA:0000024" + }, { + "val" : "MAT:0000297" + }, { + "val" : "MESH:D009333" + }, { + "val" : "MIAA:0000297" + }, { + "val" : "NCIT:C13063" + }, { + "val" : "SCTID:302550007" + }, { + "val" : "Wikipedia:Neck" + }, { + "val" : "galen:Neck" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000977", + "lbl" : "pleura", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion).", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010820", "UBERON:cjm", "Wikipedia:Pulmonary_pleurae", "https://github.com/obophenotype/uberon/issues/1231" ] + }, + "xrefs" : [ { + "val" : "BTO:0001791" + }, { + "val" : "CALOHA:TS-2081" + }, { + "val" : "EFO:0001980" + }, { + "val" : "EV:0100044" + }, { + "val" : "FMA:9583" + }, { + "val" : "GAID:360" + }, { + "val" : "MA:0000433" + }, { + "val" : "MESH:D010994" + }, { + "val" : "NCIT:C12469" + }, { + "val" : "SCTID:181609007" + }, { + "val" : "VHOG:0000394" + }, { + "val" : "Wikipedia:Pleura" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000982", + "lbl" : "skeletal joint", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO].", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000101", "Wikipedia:Joint", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AEO:0000182" + }, { + "val" : "BTO:0001686" + }, { + "val" : "CALOHA:TS-2023" + }, { + "val" : "EFO:0000948" + }, { + "val" : "EMAPA:35456" + }, { + "val" : "FMA:7490" + }, { + "val" : "GAID:102" + }, { + "val" : "MA:0000319" + }, { + "val" : "MAT:0000188" + }, { + "val" : "MESH:D007596" + }, { + "val" : "MIAA:0000188" + }, { + "val" : "NCIT:C13044" + }, { + "val" : "RETIRED_EHDAA2:0003182" + }, { + "val" : "SCTID:302536002" + }, { + "val" : "TAO:0000367" + }, { + "val" : "VHOG:0001276" + }, { + "val" : "VSAO:0000101" + }, { + "val" : "Wikipedia:Joint" + }, { + "val" : "XAO:0000171" + }, { + "val" : "ZFA:0001596" + }, { + "val" : "galen:Joint" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000988", + "lbl" : "pons", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum.", + "xrefs" : [ "VHOG:0001176" ] + }, + "xrefs" : [ { + "val" : "BAMS:PONS" + }, { + "val" : "BAMS:Pons" + }, { + "val" : "BIRNLEX:733" + }, { + "val" : "BM:Pons" + }, { + "val" : "BTO:0001101" + }, { + "val" : "CALOHA:TS-0813" + }, { + "val" : "DHBA:10661" + }, { + "val" : "EFO:0001394" + }, { + "val" : "EHDAA2:0004394" + }, { + "val" : "EMAPA:17563" + }, { + "val" : "EV:0100253" + }, { + "val" : "FMA:67943" + }, { + "val" : "GAID:578" + }, { + "val" : "HBA:9131" + }, { + "val" : "MA:0000204" + }, { + "val" : "MAT:0000115" + }, { + "val" : "MBA:771" + }, { + "val" : "MESH:D011149" + }, { + "val" : "MIAA:0000115" + }, { + "val" : "NCIT:C12511" + }, { + "val" : "SCTID:279103004" + }, { + "val" : "VHOG:0001176" + }, { + "val" : "Wikipedia:Pons" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000990", + "lbl" : "reproductive system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that has as its parts the organs concerned with reproduction.", + "xrefs" : [ "Wikipedia:Reproductive_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0010258" + }, { + "val" : "BILA:0000103" + }, { + "val" : "BTO:0000081" + }, { + "val" : "CALOHA:TS-1318" + }, { + "val" : "EFO:0000809" + }, { + "val" : "EHDAA2:0001603" + }, { + "val" : "EHDAA:5923" + }, { + "val" : "EMAPA:17381" + }, { + "val" : "EV:0100100" + }, { + "val" : "FMA:7160" + }, { + "val" : "GAID:363" + }, { + "val" : "HAO:0000374" + }, { + "val" : "HAO:0000895" + }, { + "val" : "MA:0000326" + }, { + "val" : "MIAA:0000305" + }, { + "val" : "NCIT:C12841" + }, { + "val" : "SCTID:278875001" + }, { + "val" : "TAO:0000632" + }, { + "val" : "VHOG:0000182" + }, { + "val" : "WBbt:0005747" + }, { + "val" : "Wikipedia:Reproductive_system" + }, { + "val" : "XAO:0000142" + }, { + "val" : "ZFA:0000632" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000991", + "lbl" : "gonad", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Reproductive organ that produces and releases eggs (ovary) or sperm (testis).", + "xrefs" : [ "ISBN:0140512888", "Wikipedia:Gonad", "ZFA:0000413", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0000213" + }, { + "val" : "BILA:0000123" + }, { + "val" : "BSA:0000079" + }, { + "val" : "BTO:0000534" + }, { + "val" : "EMAPA:17383" + }, { + "val" : "FMA:18250" + }, { + "val" : "GAID:368" + }, { + "val" : "HAO:0000379" + }, { + "val" : "MA:0002420" + }, { + "val" : "MESH:D006066" + }, { + "val" : "NCIT:C12725" + }, { + "val" : "SCTID:304623008" + }, { + "val" : "TAO:0000413" + }, { + "val" : "VHOG:0000397" + }, { + "val" : "WBbt:0005175" + }, { + "val" : "Wikipedia:Gonad" + }, { + "val" : "XAO:0003146" + }, { + "val" : "ZFA:0000413" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000992", + "lbl" : "ovary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The gonad of a female organism which contains germ cells.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0001126", "Wikipedia:Ovary" ] + }, + "xrefs" : [ { + "val" : "AAO:0000371" + }, { + "val" : "BILA:0000125" + }, { + "val" : "BSA:0000080" + }, { + "val" : "BTO:0000975" + }, { + "val" : "CALOHA:TS-0730" + }, { + "val" : "EFO:0000973" + }, { + "val" : "EHDAA2:0001360" + }, { + "val" : "EHDAA:8124" + }, { + "val" : "EMAPA:17962" + }, { + "val" : "EV:0100111" + }, { + "val" : "FMA:7209" + }, { + "val" : "GAID:367" + }, { + "val" : "MA:0000384" + }, { + "val" : "MESH:D010053" + }, { + "val" : "MIAA:0000125" + }, { + "val" : "NCIT:C12404" + }, { + "val" : "SCTID:181464007" + }, { + "val" : "TAO:0000403" + }, { + "val" : "VHOG:0000251" + }, { + "val" : "Wikipedia:Ovary" + }, { + "val" : "XAO:0000258" + }, { + "val" : "ZFA:0000403" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001003", + "lbl" : "skin epidermis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outer epithelial layer of the skin that is superficial to the dermis.", + "xrefs" : [ "ISBN:0073040584", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000143" + }, { + "val" : "BTO:0000404" + }, { + "val" : "CALOHA:TS-0283" + }, { + "val" : "EFO:0000954" + }, { + "val" : "EMAPA:17528" + }, { + "val" : "EV:0100153" + }, { + "val" : "FMA:70596" + }, { + "val" : "GAID:932" + }, { + "val" : "MA:0000153" + }, { + "val" : "MAT:0000154" + }, { + "val" : "MESH:D004817" + }, { + "val" : "MIAA:0000154" + }, { + "val" : "NCIT:C12708" + }, { + "val" : "SCTID:361694003" + }, { + "val" : "TAO:0000105" + }, { + "val" : "VHOG:0000077" + }, { + "val" : "Wikipedia:Epidermis_(skin)" + }, { + "val" : "XAO:0000028" + }, { + "val" : "ZFA:0000105" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001004", + "lbl" : "respiratory system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Functional system which consists of structures involved in respiration.", + "xrefs" : [ "Wikipedia:Respiratory_system", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000541" + }, { + "val" : "BTO:0000203" + }, { + "val" : "CALOHA:TS-1319" + }, { + "val" : "EFO:0000804" + }, { + "val" : "EHDAA2:0001604" + }, { + "val" : "EHDAA:2203" + }, { + "val" : "EMAPA:16727" + }, { + "val" : "EV:0100036" + }, { + "val" : "FMA:7158" + }, { + "val" : "GAID:78" + }, { + "val" : "MA:0000327" + }, { + "val" : "MAT:0000030" + }, { + "val" : "MESH:D012137" + }, { + "val" : "MIAA:0000030" + }, { + "val" : "NCIT:C12779" + }, { + "val" : "SCTID:278197002" + }, { + "val" : "TAO:0000272" + }, { + "val" : "VHOG:0000202" + }, { + "val" : "Wikipedia:Respiratory_system" + }, { + "val" : "XAO:0000117" + }, { + "val" : "ZFA:0000272" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001005", + "lbl" : "respiratory airway", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An airway through which respiratory air passes in organisms.", + "xrefs" : [ "Wikipedia:Trachea" ] + }, + "xrefs" : [ { + "val" : "SCTID:361380005" + }, { + "val" : "Wikipedia:Trachea" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001007", + "lbl" : "digestive system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes.", + "xrefs" : [ "FB:gg", "NLM:alimentary+system", "Wikipedia:Digestive_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0000129" + }, { + "val" : "BILA:0000082" + }, { + "val" : "BTO:0000058" + }, { + "val" : "CALOHA:TS-1293" + }, { + "val" : "EFO:0000793" + }, { + "val" : "FMA:7152" + }, { + "val" : "GAID:278" + }, { + "val" : "MA:0002431" + }, { + "val" : "MAT:0000018" + }, { + "val" : "MESH:D004064" + }, { + "val" : "MIAA:0000018" + }, { + "val" : "SCTID:278859004" + }, { + "val" : "TADS:0000170" + }, { + "val" : "TAO:0000339" + }, { + "val" : "WBbt:0005748" + }, { + "val" : "Wikipedia:Digestive_system" + }, { + "val" : "XAO:0000125" + }, { + "val" : "ZFA:0000339" + }, { + "val" : "galen:DigestiveSystem" + }, { + "val" : "ncithesaurus:Digestive_System" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "lbl" : "renal system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products.", + "xrefs" : [ "DOI:10.1371/journal.pone.0099864", "GO:0072001" ] + }, + "comments" : [ "EDITOR_NOTE In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here" ], + "xrefs" : [ { + "val" : "AAO:0010257" + }, { + "val" : "BILA:0000015" + }, { + "val" : "BTO:0001244" + }, { + "val" : "BTO:0003092" + }, { + "val" : "CALOHA:TS-1323" + }, { + "val" : "EFO:0000803" + }, { + "val" : "EHDAA2:0001601" + }, { + "val" : "EHDAA:5901" + }, { + "val" : "EMAPA:17366" + }, { + "val" : "EV:0100095" + }, { + "val" : "FMA:7159" + }, { + "val" : "GAID:391" + }, { + "val" : "MA:0000325" + }, { + "val" : "MAT:0000027" + }, { + "val" : "MESH:D014551" + }, { + "val" : "MIAA:0000027" + }, { + "val" : "NCIT:C12413" + }, { + "val" : "SCTID:362204003" + }, { + "val" : "TADS:0000162" + }, { + "val" : "TAO:0000163" + }, { + "val" : "VHOG:0000723" + }, { + "val" : "WBbt:0005736" + }, { + "val" : "Wikipedia:Excretory_system" + }, { + "val" : "XAO:0000143" + }, { + "val" : "ZFA:0000163" + }, { + "val" : "galen:UrinaryTract" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001009", + "lbl" : "circulatory system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP].", + "xrefs" : [ "Wikipedia:Circulatory_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0000959" + }, { + "val" : "CALOHA:TS-2103" + }, { + "val" : "VHOG:0001248" + }, { + "val" : "Wikipedia:Circulatory_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001013", + "lbl" : "adipose tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue.", + "xrefs" : [ "MESH:A10.165.114", "MGI:cwg", "MP:0000003", "Wikipedia:Adipose_tissue", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000001" + }, { + "val" : "AEO:000020" + }, { + "val" : "BTO:0001487" + }, { + "val" : "CALOHA:TS-0013" + }, { + "val" : "EFO:0000790" + }, { + "val" : "EHDAA2:0003120" + }, { + "val" : "EMAPA:35112" + }, { + "val" : "EV:0100381" + }, { + "val" : "FMA:20110" + }, { + "val" : "GAID:920" + }, { + "val" : "MA:0000009" + }, { + "val" : "MAT:0000015" + }, { + "val" : "MESH:D000273" + }, { + "val" : "MIAA:0000015" + }, { + "val" : "NCIT:C12472" + }, { + "val" : "SCTID:55603005" + }, { + "val" : "TAO:0002134" + }, { + "val" : "VHOG:0001284" + }, { + "val" : "Wikipedia:Adipose_tissue" + }, { + "val" : "XAO:0003049" + }, { + "val" : "ZFA:0005345" + }, { + "val" : "galen:FattyTissue" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001015", + "lbl" : "musculature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the muscular system corresponding to a subdisivision of an organism.", + "xrefs" : [ "Wikipedia:Muscular_system", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000887" + }, { + "val" : "EFO:0001949" + }, { + "val" : "EMAPA:35577" + }, { + "val" : "FMA:32558" + }, { + "val" : "MA:0000165" + }, { + "val" : "NCIT:C13056" + }, { + "val" : "TAO:0000548" + }, { + "val" : "VSAO:0005038" + }, { + "val" : "WBbt:0005737" + }, { + "val" : "Wikipedia:Muscular_system" + }, { + "val" : "ZFA:0000548" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001016", + "lbl" : "nervous system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].", + "xrefs" : [ "BIRNLEX:844", "ISBN:0-14-051288-8", "ISBN:3110148986", "NLM:nervous+system", "WB:rynl", "Wikipedia:Nervous_system", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0000324" + }, { + "val" : "BILA:0000079" + }, { + "val" : "BIRNLEX:844" + }, { + "val" : "BTO:0001484" + }, { + "val" : "CALOHA:TS-1313" + }, { + "val" : "EFO:0000802" + }, { + "val" : "EHDAA2:0001246" + }, { + "val" : "EHDAA:826" + }, { + "val" : "EMAPA:16469" + }, { + "val" : "EV:0100162" + }, { + "val" : "FMA:7157" + }, { + "val" : "GAID:466" + }, { + "val" : "MA:0000016" + }, { + "val" : "MAT:0000026" + }, { + "val" : "MESH:D009420" + }, { + "val" : "MIAA:0000026" + }, { + "val" : "NCIT:C12755" + }, { + "val" : "SCTID:278196006" + }, { + "val" : "TAO:0000396" + }, { + "val" : "VHOG:0000402" + }, { + "val" : "WBbt:0005735" + }, { + "val" : "Wikipedia:Nervous_system" + }, { + "val" : "XAO:0000177" + }, { + "val" : "ZFA:0000396" + }, { + "val" : "neuronames:3236" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001017", + "lbl" : "central nervous system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.", + "xrefs" : [ "GO:0021551", "http://www.frontiersinzoology.com/content/7/1/29", "https://sourceforge.net/p/geneontology/ontology-requests/11422/" ] + }, + "xrefs" : [ { + "val" : "AAO:0000090" + }, { + "val" : "BAMS:CNS" + }, { + "val" : "BILA:0000080" + }, { + "val" : "BIRNLEX:1099" + }, { + "val" : "BTO:0000227" + }, { + "val" : "CALOHA:TS-0150" + }, { + "val" : "EFO:0000908" + }, { + "val" : "EHDAA2:0000225" + }, { + "val" : "EHDAA:828" + }, { + "val" : "EMAPA:16470" + }, { + "val" : "EMAPA:16754" + }, { + "val" : "EV:0100163" + }, { + "val" : "FMA:55675" + }, { + "val" : "GAID:570" + }, { + "val" : "MA:0000167" + }, { + "val" : "MAT:0000457" + }, { + "val" : "MESH:D002490" + }, { + "val" : "NCIT:C12438" + }, { + "val" : "SCTID:278199004" + }, { + "val" : "TAO:0000012" + }, { + "val" : "VHOG:0000293" + }, { + "val" : "Wikipedia:Central_nervous_system" + }, { + "val" : "XAO:0000215" + }, { + "val" : "ZFA:0000012" + }, { + "val" : "neuronames:854" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001021", + "lbl" : "nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures.", + "xrefs" : [ "FBbt:00005105", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011070" + }, { + "val" : "AEO:0000137" + }, { + "val" : "BAMS:n" + }, { + "val" : "BIRNLEX:1615" + }, { + "val" : "BSA:0000098" + }, { + "val" : "BTO:0000925" + }, { + "val" : "BTO:0001027" + }, { + "val" : "CALOHA:TS-0772" + }, { + "val" : "EHDAA2:0003137" + }, { + "val" : "EHDAA:2851" + }, { + "val" : "EHDAA:3776" + }, { + "val" : "EHDAA:4657" + }, { + "val" : "EMAPA:32808" + }, { + "val" : "EMAPA:32815" + }, { + "val" : "EV:0100371" + }, { + "val" : "FMA:65132" + }, { + "val" : "FMA:65239" + }, { + "val" : "GAID:747" + }, { + "val" : "GAID:758" + }, { + "val" : "MA:0000217" + }, { + "val" : "MA:0000228" + }, { + "val" : "MESH:D010525" + }, { + "val" : "NCIT:C12466" + }, { + "val" : "NCIT:C12768" + }, { + "val" : "NLX:147826" + }, { + "val" : "SCTID:244457007" + }, { + "val" : "SCTID:256864008" + }, { + "val" : "TAO:0007009" + }, { + "val" : "VHOG:0000901" + }, { + "val" : "Wikipedia:Nervous_system" + }, { + "val" : "XAO:0000204" + }, { + "val" : "XAO:0003047" + }, { + "val" : "ZFA:0007009" + }, { + "val" : "galen:Nerve" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001027", + "lbl" : "sensory nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that transmits from sensory receptors on the surface of the body to the central nervous system.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Sensory_nerve" ] + }, + "xrefs" : [ { + "val" : "AEO:0000201" + }, { + "val" : "EHDAA2:0003200" + }, { + "val" : "FMA:5868" + }, { + "val" : "Wikipedia:Sensory_nerve" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001032", + "lbl" : "sensory system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information.", + "xrefs" : [ "Wikipedia:Sensory_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0000555" + }, { + "val" : "BAMS:SEN" + }, { + "val" : "BILA:0000099" + }, { + "val" : "EFO:0000805" + }, { + "val" : "EHDAA2:0003094" + }, { + "val" : "EMAPA:16192" + }, { + "val" : "FMA:75259" + }, { + "val" : "MA:0002442" + }, { + "val" : "MAT:0000031" + }, { + "val" : "MIAA:0000031" + }, { + "val" : "NLXANAT:090816" + }, { + "val" : "TAO:0000282" + }, { + "val" : "VHOG:0001674" + }, { + "val" : "Wikipedia:Sensory_system" + }, { + "val" : "XAO:0003194" + }, { + "val" : "ZFA:0000282" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001040", + "lbl" : "yolk sac", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP].", + "xrefs" : [ "Wikipedia:Yolk_sac" ] + }, + "xrefs" : [ { + "val" : "BTO:0001471" + }, { + "val" : "CALOHA:TS-1130" + }, { + "val" : "EFO:0003078" + }, { + "val" : "EHDAA2:0002212" + }, { + "val" : "EHDAA:164" + }, { + "val" : "EMAPA:16085" + }, { + "val" : "FMA:87180" + }, { + "val" : "GAID:1301" + }, { + "val" : "MESH:D015017" + }, { + "val" : "NCIT:C14128" + }, { + "val" : "SCTID:362845002" + }, { + "val" : "VHOG:0000830" + }, { + "val" : "Wikipedia:Yolk_sac" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001041", + "lbl" : "foregut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anterior subdivision of a digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011042" + }, { + "val" : "BILA:0000085" + }, { + "val" : "BTO:0000507" + }, { + "val" : "EHDAA2:0000557" + }, { + "val" : "EHDAA:520" + }, { + "val" : "EMAPA:16548" + }, { + "val" : "FMA:45616" + }, { + "val" : "MA:0001526" + }, { + "val" : "NCIT:C34180" + }, { + "val" : "SCTID:361409009" + }, { + "val" : "TGMA:0001014" + }, { + "val" : "VHOG:0000285" + }, { + "val" : "Wikipedia:Foregut" + }, { + "val" : "XAO:0000232" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001042", + "lbl" : "chordate pharynx", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED].", + "xrefs" : [ "http://www.feedexp.org" ] + }, + "comments" : [ "Consider generalizing to deuterostome pharynx" ], + "xrefs" : [ { + "val" : "AAO:0000967" + }, { + "val" : "BTO:0001049" + }, { + "val" : "CALOHA:TS-0785" + }, { + "val" : "EFO:0000836" + }, { + "val" : "EHDAA2:0001458" + }, { + "val" : "EHDAA:2947" + }, { + "val" : "EMAPA:16706" + }, { + "val" : "EV:0100065" + }, { + "val" : "FMA:46688" + }, { + "val" : "GAID:155" + }, { + "val" : "MA:0000432" + }, { + "val" : "MESH:D010614" + }, { + "val" : "NCIT:C12425" + }, { + "val" : "SCTID:181211006" + }, { + "val" : "TAO:0000056" + }, { + "val" : "VHOG:0000462" + }, { + "val" : "Wikipedia:Pharynx" + }, { + "val" : "XAO:0003227" + }, { + "val" : "ZFA:0000056" + }, { + "val" : "galen:Pharynx" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001043", + "lbl" : "esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).", + "xrefs" : [ "Wikipedia:Esophagus", "http://www.rivm.nl/interspeciesinfo/inter/oesophagus/" ] + }, + "xrefs" : [ { + "val" : "AAO:0000145" + }, { + "val" : "ANISEED:1235301" + }, { + "val" : "BTO:0000959" + }, { + "val" : "CALOHA:TS-0700" + }, { + "val" : "EFO:0000835" + }, { + "val" : "EHDAA2:0001285" + }, { + "val" : "EHDAA:2937" + }, { + "val" : "EMAPA:16833" + }, { + "val" : "EV:0100069" + }, { + "val" : "FMA:7131" + }, { + "val" : "GAID:291" + }, { + "val" : "MA:0000352" + }, { + "val" : "MAT:0000048" + }, { + "val" : "MESH:D004947" + }, { + "val" : "MIAA:0000048" + }, { + "val" : "NCIT:C12389" + }, { + "val" : "SCTID:181245004" + }, { + "val" : "TAO:0000204" + }, { + "val" : "VHOG:0000450" + }, { + "val" : "Wikipedia:Esophagus" + }, { + "val" : "XAO:0000127" + }, { + "val" : "ZFA:0000204" + }, { + "val" : "galen:Esophagus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001045", + "lbl" : "midgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO].", + "xrefs" : [ "GO:0007494", "Wikipedia:Midgut" ] + }, + "xrefs" : [ { + "val" : "BILA:0000086" + }, { + "val" : "BTO:0000863" + }, { + "val" : "EFO:0001950" + }, { + "val" : "EHDAA2:0001185" + }, { + "val" : "EHDAA:983" + }, { + "val" : "EMAPA:16255" + }, { + "val" : "FMA:45617" + }, { + "val" : "MA:0001564" + }, { + "val" : "NCIT:C34210" + }, { + "val" : "SCTID:361410004" + }, { + "val" : "TGMA:0001036" + }, { + "val" : "VHOG:0000290" + }, { + "val" : "Wikipedia:Midgut" + }, { + "val" : "XAO:0000103" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001046", + "lbl" : "hindgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The caudalmost subdivision of a digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011052" + }, { + "val" : "BILA:0000087" + }, { + "val" : "BTO:0000510" + }, { + "val" : "EHDAA2:0000779" + }, { + "val" : "EHDAA:975" + }, { + "val" : "EMAPA:16715" + }, { + "val" : "FMA:45618" + }, { + "val" : "MA:0001527" + }, { + "val" : "NCIT:C34188" + }, { + "val" : "SCTID:362856002" + }, { + "val" : "TGMA:0001020" + }, { + "val" : "VHOG:0000459" + }, { + "val" : "Wikipedia:Hindgut" + }, { + "val" : "XAO:0000104" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001048", + "lbl" : "primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)].", + "xrefs" : [ "BTO:0001886", "FB:DJS", "FB:FBrf0089570", "http://flybase.org/reports/FBrf0178740.html" ] + }, + "xrefs" : [ { + "val" : "AEO:0000171" + }, { + "val" : "BTO:0001886" + }, { + "val" : "EFO:0001652" + }, { + "val" : "EHDAA2:0003171" + }, { + "val" : "FMA:86589" + }, { + "val" : "MAT:0000482" + }, { + "val" : "NCIT:C34275" + }, { + "val" : "Wikipedia:Primordium" + }, { + "val" : "XAO:0003043" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001049", + "lbl" : "neural tube", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Neural_tube" ] + }, + "xrefs" : [ { + "val" : "AAO:0010617" + }, { + "val" : "BTO:0001057" + }, { + "val" : "CALOHA:TS-2371" + }, { + "val" : "DHBA:10154" + }, { + "val" : "EHDAA2:0001254" + }, { + "val" : "EHDAA:2869" + }, { + "val" : "EHDAA:908" + }, { + "val" : "EMAPA:16164" + }, { + "val" : "EMAPA:16757" + }, { + "val" : "FMA:293882" + }, { + "val" : "MAT:0000069" + }, { + "val" : "MIAA:0000069" + }, { + "val" : "NCIT:C34226" + }, { + "val" : "SCTID:362852000" + }, { + "val" : "TAO:0001135" + }, { + "val" : "VHOG:0000307" + }, { + "val" : "Wikipedia:Neural_tube" + }, { + "val" : "XAO:0003204" + }, { + "val" : "ZFA:0001135" + }, { + "val" : "neuronames:1365" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "lbl" : "rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The terminal portion of the intestinal tube, terminating with the anus.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0000492", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010401" + }, { + "val" : "BTO:0001158" + }, { + "val" : "CALOHA:TS-1180" + }, { + "val" : "EFO:0000848" + }, { + "val" : "EHDAA2:0001592" + }, { + "val" : "EHDAA:5836" + }, { + "val" : "EMAPA:17896" + }, { + "val" : "EV:0100081" + }, { + "val" : "FMA:14544" + }, { + "val" : "GAID:311" + }, { + "val" : "MA:0000336" + }, { + "val" : "MAT:0000050" + }, { + "val" : "MESH:D012007" + }, { + "val" : "MIAA:0000050" + }, { + "val" : "NCIT:C12390" + }, { + "val" : "SCTID:181261002" + }, { + "val" : "VHOG:0001751" + }, { + "val" : "Wikipedia:Rectum" + }, { + "val" : "XAO:0000238" + }, { + "val" : "galen:Rectum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001062", + "lbl" : "anatomical entity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.", + "xrefs" : [ "FMA:62955", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010841" + }, { + "val" : "AEO:0000000" + }, { + "val" : "BFO:0000004" + }, { + "val" : "BILA:0000000" + }, { + "val" : "BIRNLEX:6" + }, { + "val" : "CARO:0000000" + }, { + "val" : "EHDAA2:0002229" + }, { + "val" : "FMA:62955" + }, { + "val" : "HAO:0000000" + }, { + "val" : "MA:0000001" + }, { + "val" : "NCIT:C12219" + }, { + "val" : "TAO:0100000" + }, { + "val" : "TGMA:0001822" + }, { + "val" : "WBbt:0000100" + }, { + "val" : "XAO:0000000" + }, { + "val" : "ZFA:0100000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "lbl" : "ventral pancreatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla.", + "xrefs" : [ "Wikipedia:Pancreatic_duct" ] + }, + "comments" : [ "EDITOR_NOTE in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue" ], + "xrefs" : [ { + "val" : "BTO:0002362" + }, { + "val" : "EHDAA2:0001396" + }, { + "val" : "EHDAA:6905" + }, { + "val" : "EMAPA:17510" + }, { + "val" : "FMA:16003" + }, { + "val" : "GAID:337" + }, { + "val" : "MA:0000126" + }, { + "val" : "MESH:D010183" + }, { + "val" : "NCIT:C12272" + }, { + "val" : "RETIRED_EHDAA2:0002177" + }, { + "val" : "SCTID:245385001" + }, { + "val" : "VHOG:0000256" + }, { + "val" : "Wikipedia:Pancreatic_duct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001068", + "lbl" : "skin of back", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region" ], + "xrefs" : [ { + "val" : "EMAPA:36392" + }, { + "val" : "FMA:10462" + }, { + "val" : "FMA:22985" + }, { + "val" : "MA:0000498" + }, { + "val" : "SCTID:181492002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001070", + "lbl" : "external carotid artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP].", + "xrefs" : [ "MGI:anna" ] + }, + "xrefs" : [ { + "val" : "AAO:0010218" + }, { + "val" : "AAO:0010416" + }, { + "val" : "BTO:0004696" + }, { + "val" : "EFO:0001953" + }, { + "val" : "EHDAA2:0000461" + }, { + "val" : "EMAPA:18611" + }, { + "val" : "FMA:10635" + }, { + "val" : "GAID:480" + }, { + "val" : "MA:0001929" + }, { + "val" : "MESH:D002342" + }, { + "val" : "NCIT:C32551" + }, { + "val" : "SCTID:362044002" + }, { + "val" : "VHOG:0000265" + }, { + "val" : "Wikipedia:External_carotid_artery" + }, { + "val" : "XAO:0000345" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001071", + "lbl" : "superficial cervical artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery.", + "xrefs" : [ "Wikipedia:Superficial_part_of_transverse_cervical_artery" ] + }, + "comments" : [ "The transverse cervical artery splits into two branches, a superficial one and a deep one[WP]" ], + "xrefs" : [ { + "val" : "FMA:10665" + }, { + "val" : "MA:0002052" + }, { + "val" : "NCIT:C53005" + }, { + "val" : "SCTID:161746006" + }, { + "val" : "Wikipedia:Superficial_part_of_transverse_cervical_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001072", + "lbl" : "inferior vena cava", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart.", + "xrefs" : [ "Wikipedia:Inferior_vena_cava", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011083" + }, { + "val" : "BTO:0002682" + }, { + "val" : "EHDAA2:0000611" + }, { + "val" : "EMAPA:18416" + }, { + "val" : "FMA:10951" + }, { + "val" : "GAID:548" + }, { + "val" : "MA:0000480" + }, { + "val" : "MESH:D014682" + }, { + "val" : "NCIT:C12815" + }, { + "val" : "SCTID:181369003" + }, { + "val" : "VHOG:0001194" + }, { + "val" : "Wikipedia:Inferior_vena_cava" + }, { + "val" : "XAO:0000388" + }, { + "val" : "galen:InferiorVenaCava" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "lbl" : "ileocecal junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice.", + "xrefs" : [ "http://www.medilexicon.com/medicaldictionary.php?t=46539" ] + }, + "xrefs" : [ { + "val" : "FMA:11338" + }, { + "val" : "MA:0000332" + }, { + "val" : "SCTID:264021000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001074", + "lbl" : "pericardial cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A potential space between the visceral and parietal layers of the pericardium.", + "xrefs" : [ "Wikipedia:Pericardium" ] + }, + "xrefs" : [ { + "val" : "BSA:0000091" + }, { + "val" : "EHDAA2:0001434" + }, { + "val" : "EMAPA:16131" + }, { + "val" : "EMAPA:16132" + }, { + "val" : "FMA:11350" + }, { + "val" : "MA:0000053" + }, { + "val" : "NCIT:C38662" + }, { + "val" : "SCTID:362027001" + }, { + "val" : "TAO:0002220" + }, { + "val" : "VHOG:0000556" + }, { + "val" : "Wikipedia:Pericardial_cavity" + }, { + "val" : "ZFA:0001655" + }, { + "val" : "galen:PericardialSpace" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001081", + "lbl" : "endocardium of ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endocardium that is part of the cardiac ventricle.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32747" + }, { + "val" : "FMA:12148" + }, { + "val" : "MA:0000079" + }, { + "val" : "SCTID:192172004" + }, { + "val" : "TAO:0002247" + }, { + "val" : "VHOG:0000607" + }, { + "val" : "ZFA:0001615" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001082", + "lbl" : "epicardium of ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epicardial layer that lines a cardiac ventricle.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:12150" + }, { + "val" : "TAO:0005058" + }, { + "val" : "ZFA:0005058" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001083", + "lbl" : "myocardium of ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EFO:0003088" + }, { + "val" : "EMAPA:32748" + }, { + "val" : "FMA:12151" + }, { + "val" : "MA:0000082" + }, { + "val" : "SCTID:192084000" + }, { + "val" : "TAO:0005061" + }, { + "val" : "VHOG:0000604" + }, { + "val" : "ZFA:0005061" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001084", + "lbl" : "skin of head", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region" ], + "xrefs" : [ { + "val" : "FMA:12166" + }, { + "val" : "FMA:24756" + }, { + "val" : "MA:0000582" + }, { + "val" : "NCIT:C52757" + }, { + "val" : "SCTID:181484006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001085", + "lbl" : "skin of trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region" ], + "xrefs" : [ { + "val" : "FMA:12167" + }, { + "val" : "FMA:23093" + }, { + "val" : "MA:0000517" + }, { + "val" : "NCIT:C12295" + }, { + "val" : "SCTID:181489001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001087", + "lbl" : "pleural fluid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Transudate contained in the pleural cavity.", + "xrefs" : [ "FMA:12273" ] + }, + "xrefs" : [ { + "val" : "BTO:0003080" + }, { + "val" : "FMA:12273" + }, { + "val" : "MA:0002532" + }, { + "val" : "MAT:0000500" + }, { + "val" : "Wikipedia:Pleural_fluid" + }, { + "val" : "ncithesaurus:Pleural_Fluid" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001090", + "lbl" : "synovial fluid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Joint fluid is a transudate of plasma that is actively secreted by synovial cells.", + "xrefs" : [ "https://www.ncbi.nlm.nih.gov/books/NBK274/" ] + }, + "xrefs" : [ { + "val" : "BTO:0001339" + }, { + "val" : "CALOHA:TS-0996" + }, { + "val" : "ENVO:02000039" + }, { + "val" : "FMA:12277" + }, { + "val" : "GAID:265" + }, { + "val" : "MA:0002544" + }, { + "val" : "MESH:D013582" + }, { + "val" : "NCIT:C33718" + }, { + "val" : "TAO:0005154" + }, { + "val" : "Wikipedia:Synovial_fluid" + }, { + "val" : "ZFA:0005154" + }, { + "val" : "galen:SynovialFluid" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001092", + "lbl" : "vertebral bone 1", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first vertebral bone in the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000709" + }, { + "val" : "EHDAA:10606" + }, { + "val" : "EMAPA:19431" + }, { + "val" : "FMA:12519" + }, { + "val" : "GAID:236" + }, { + "val" : "MA:0001421" + }, { + "val" : "MESH:D001270" + }, { + "val" : "NCIT:C32239" + }, { + "val" : "SCTID:181818007" + }, { + "val" : "TAO:0001167" + }, { + "val" : "Wikipedia:Atlas_(anatomy)" + }, { + "val" : "ZFA:0001167" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001093", + "lbl" : "vertebral bone 2", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The second vertebral bone in the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA:10608" + }, { + "val" : "EMAPA:19432" + }, { + "val" : "FMA:12520" + }, { + "val" : "GAID:237" + }, { + "val" : "MA:0001422" + }, { + "val" : "MESH:D001368" + }, { + "val" : "NCIT:C32240" + }, { + "val" : "SCTID:181819004" + }, { + "val" : "TAO:0001168" + }, { + "val" : "Wikipedia:Axis_(anatomy)" + }, { + "val" : "ZFA:0001168" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001095", + "lbl" : "caudal vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Taxon notes In zebrafish, Vertebra bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae" ], + "xrefs" : [ { + "val" : "EMAPA:18374" + }, { + "val" : "FMA:12527" + }, { + "val" : "MA:0000310" + }, { + "val" : "MA:0001420" + }, { + "val" : "NCIT:C32334" + }, { + "val" : "SCTID:361774004" + }, { + "val" : "TAO:0000326" + }, { + "val" : "Wikipedia:Caudal_vertebra" + }, { + "val" : "XAO:0003079" + }, { + "val" : "ZFA:0000326" + }, { + "val" : "galen:CoccygealVertebra" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001096", + "lbl" : "wall of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35326" + }, { + "val" : "FMA:12611" + }, { + "val" : "MA:0002691" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001103", + "lbl" : "diaphragm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control.", + "xrefs" : [ "MP:0002279" ] + }, + "xrefs" : [ { + "val" : "BTO:0000341" + }, { + "val" : "CALOHA:TS-0198" + }, { + "val" : "EFO:0000937" + }, { + "val" : "EHDAA2:0003495" + }, { + "val" : "EMAPA:17701" + }, { + "val" : "EV:0100376" + }, { + "val" : "FMA:13295" + }, { + "val" : "GAID:158" + }, { + "val" : "MA:0001904" + }, { + "val" : "MAT:0000502" + }, { + "val" : "MESH:D003964" + }, { + "val" : "NCIT:C12702" + }, { + "val" : "SCTID:181614006" + }, { + "val" : "VHOG:0000713" + }, { + "val" : "Wikipedia:Thoracid_diaphragm" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001113", + "lbl" : "lobe of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe.", + "xrefs" : [ "Wikipedia:Liver#Lobes" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18306" + }, { + "val" : "FMA:13361" + }, { + "val" : "MA:0000360" + }, { + "val" : "NCIT:C49579" + }, { + "val" : "SCTID:245378000" + }, { + "val" : "Wikipedia:Liver#Lobes" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001114", + "lbl" : "right lobe of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Right_lobe_of_liver" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001008" + }, { + "val" : "EHDAA:4001" + }, { + "val" : "EMAPA:18311" + }, { + "val" : "FMA:13362" + }, { + "val" : "MA:0000363" + }, { + "val" : "NCIT:C33481" + }, { + "val" : "SCTID:362182008" + }, { + "val" : "TAO:0005173" + }, { + "val" : "VHOG:0001424" + }, { + "val" : "Wikipedia:Right_lobe_of_liver" + }, { + "val" : "ZFA:0005173" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001115", + "lbl" : "left lobe of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Left_lobe_of_liver" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001000" + }, { + "val" : "EHDAA:3995" + }, { + "val" : "EMAPA:18307" + }, { + "val" : "FMA:13363" + }, { + "val" : "MA:0000361" + }, { + "val" : "NCIT:C32965" + }, { + "val" : "SCTID:362183003" + }, { + "val" : "TAO:0005172" + }, { + "val" : "VHOG:0001423" + }, { + "val" : "Wikipedia:Left_lobe_of_liver" + }, { + "val" : "ZFA:0005172" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "lbl" : "vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO].", + "xrefs" : [ "VSAO:0000185", "https://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/tracker/?func=detail&aid=3530322&group_id=76834&atid=2257941" ] + }, + "xrefs" : [ { + "val" : "AAO:0000699" + }, { + "val" : "AAO:0000734" + }, { + "val" : "BTO:0000818" + }, { + "val" : "EFO:0001369" + }, { + "val" : "EHDA:10119" + }, { + "val" : "EMAPA:35919" + }, { + "val" : "FMA:13478" + }, { + "val" : "GAID:106" + }, { + "val" : "MA:0002416" + }, { + "val" : "MESH:D013131" + }, { + "val" : "NCIT:C12998" + }, { + "val" : "NCIT:C33588" + }, { + "val" : "NIF_Subcellular:sao1145756102" + }, { + "val" : "SCTID:44300000" + }, { + "val" : "TAO:0001559" + }, { + "val" : "VHOG:0001142" + }, { + "val" : "VSAO:0000185" + }, { + "val" : "Wikipedia:Vertebral_column" + }, { + "val" : "XAO:0003074" + }, { + "val" : "ZFA:0001559" + }, { + "val" : "galen:SpinalColumn" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001133", + "lbl" : "cardiac muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified].", + "xrefs" : [ "ZFA:0005280" ] + }, + "xrefs" : [ { + "val" : "AAO:0010245" + }, { + "val" : "AEO:0000142" + }, { + "val" : "BILA:0000134" + }, { + "val" : "BTO:0000199" + }, { + "val" : "CALOHA:TS-0440" + }, { + "val" : "EHDAA2:0003142" + }, { + "val" : "EMAPA:32688" + }, { + "val" : "FMA:14068" + }, { + "val" : "TAO:0005280" + }, { + "val" : "Wikipedia:Cardiac_muscle" + }, { + "val" : "ZFA:0005280" + }, { + "val" : "galen:CardiacMuscle" + }, { + "val" : "galen:CardiacMuscleTissue" + }, { + "val" : "ncithesaurus:Heart_Muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001134", + "lbl" : "skeletal muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle tissue that consists primarily of skeletal muscle fibers.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/324" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32716" + }, { + "val" : "FMA:14069" + }, { + "val" : "MA:0002439" + }, { + "val" : "NCIT:C13050" + }, { + "val" : "SCTID:426215008" + }, { + "val" : "Wikipedia:Skeletal_striated_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001135", + "lbl" : "smooth muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO].", + "xrefs" : [ "GO:0006939", "Wikipedia:Smooth_muscle_tissue" ] + }, + "xrefs" : [ { + "val" : "AAO:0010244" + }, { + "val" : "AEO:0000141" + }, { + "val" : "BTO:0001260" + }, { + "val" : "CALOHA:TS-0943" + }, { + "val" : "EFO:0000889" + }, { + "val" : "EHDAA2:0003141" + }, { + "val" : "EMAPA:32717" + }, { + "val" : "EV:0100378" + }, { + "val" : "FMA:14070" + }, { + "val" : "GAID:167" + }, { + "val" : "MA:0000166" + }, { + "val" : "MAT:0000303" + }, { + "val" : "MESH:D009130" + }, { + "val" : "MIAA:0000303" + }, { + "val" : "NCIT:C12437" + }, { + "val" : "TAO:0005274" + }, { + "val" : "VHOG:0001246" + }, { + "val" : "WBbt:0005781" + }, { + "val" : "Wikipedia:Smooth_muscle_tissue" + }, { + "val" : "XAO:0000175" + }, { + "val" : "ZFA:0005274" + }, { + "val" : "galen:SmoothMuscle" + }, { + "val" : "galen:SmoothMuscleTissue" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001136", + "lbl" : "mesothelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri).", + "xrefs" : [ "FMA:14074", "Wikipedia:Mesothelium" ] + }, + "xrefs" : [ { + "val" : "AEO:0000111" + }, { + "val" : "BTO:0002422" + }, { + "val" : "CALOHA:TS-1183" + }, { + "val" : "EHDAA2_RETIRED:0003111" + }, { + "val" : "EHDAA:2331" + }, { + "val" : "EHDAA:2349" + }, { + "val" : "EHDAA:295" + }, { + "val" : "EHDAA:6073" + }, { + "val" : "EHDAA:640" + }, { + "val" : "EHDAA:646" + }, { + "val" : "EMAPA:32856" + }, { + "val" : "FMA:14074" + }, { + "val" : "MA:0000565" + }, { + "val" : "NCIT:C33105" + }, { + "val" : "SCTID:361918002" + }, { + "val" : "Wikipedia:Mesothelium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001137", + "lbl" : "dorsum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column..", + "xrefs" : [ "BSPO:0000063", "UBERONREF:0000006", "Wikipedia:Dorsum_(anatomy)" ] + }, + "xrefs" : [ { + "val" : "BTO:0001713" + }, { + "val" : "CALOHA:TS-2223" + }, { + "val" : "EFO:0001405" + }, { + "val" : "FMA:14181" + }, { + "val" : "GAID:30" + }, { + "val" : "MESH:D001415" + }, { + "val" : "NCIT:C13062" + }, { + "val" : "SCTID:123961009" + }, { + "val" : "Wikipedia:Dorsum_(anatomy)" + }, { + "val" : "galen:Back" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "lbl" : "superior mesenteric vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Superior_mesenteric_vein" ] + }, + "xrefs" : [ { + "val" : "BTO:0002783" + }, { + "val" : "EHDAA2:0001951" + }, { + "val" : "EHDAA:5414" + }, { + "val" : "EMAPA:18643" + }, { + "val" : "FMA:14332" + }, { + "val" : "MA:0002179" + }, { + "val" : "NCIT:C33687" + }, { + "val" : "SCTID:278031001" + }, { + "val" : "VHOG:0000552" + }, { + "val" : "Wikipedia:Superior_mesenteric_vein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "lbl" : "hepatic vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vein that carries blood away from the liver[ZFA].", + "xrefs" : [ "Wikipedia:Hepatic_vein", "ZFA:0000670", "https://sourceforge.net/tracker/?func=detail&aid=3565355&group_id=76834&atid=1205376" ] + }, + "xrefs" : [ { + "val" : "AAO:0010216" + }, { + "val" : "EMAPA:19221" + }, { + "val" : "FMA:14337" + }, { + "val" : "GAID:534" + }, { + "val" : "MA:0003015" + }, { + "val" : "MESH:D006503" + }, { + "val" : "NCIT:C32736" + }, { + "val" : "SCTID:278191001" + }, { + "val" : "TAO:0000670" + }, { + "val" : "Wikipedia:Hepatic_vein" + }, { + "val" : "XAO:0000387" + }, { + "val" : "ZFA:0000670" + }, { + "val" : "galen:HepaticVein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001145", + "lbl" : "ovarian vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries.", + "xrefs" : [ "Wikipedia:Ovarian_vein" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18644" + }, { + "val" : "FMA:14346" + }, { + "val" : "MA:0002186" + }, { + "val" : "NCIT:C53058" + }, { + "val" : "SCTID:278193003" + }, { + "val" : "Wikipedia:Ovarian_vein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "lbl" : "cystic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0009493" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000333" + }, { + "val" : "EHDAA:3045" + }, { + "val" : "EMAPA:16841" + }, { + "val" : "FMA:14539" + }, { + "val" : "GAID:290" + }, { + "val" : "MA:0000355" + }, { + "val" : "MESH:D003549" + }, { + "val" : "NCIT:C32421" + }, { + "val" : "SCTID:245398005" + }, { + "val" : "TAO:0005166" + }, { + "val" : "VHOG:0000213" + }, { + "val" : "Wikipedia:Cystic_duct" + }, { + "val" : "ZFA:0005166" + }, { + "val" : "galen:CysticDuct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001155", + "lbl" : "colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal.", + "xrefs" : [ "Wikipedia:Colon_(anatomy)", "ZFIN:curator", "http://orcid.org/0000-0002-2825-0621", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010400" + }, { + "val" : "BTO:0000269" + }, { + "val" : "CALOHA:TS-0158" + }, { + "val" : "EFO:0000361" + }, { + "val" : "EMAPA:18939" + }, { + "val" : "EV:0100079" + }, { + "val" : "FMA:14543" + }, { + "val" : "GAID:309" + }, { + "val" : "MA:0000335" + }, { + "val" : "MAP:0000001" + }, { + "val" : "MAT:0000526" + }, { + "val" : "MESH:D003106" + }, { + "val" : "NCIT:C12382" + }, { + "val" : "SCTID:302508007" + }, { + "val" : "TAO:0000706" + }, { + "val" : "VHOG:0000648" + }, { + "val" : "Wikipedia:Colon_(anatomy)" + }, { + "val" : "XAO:0000243" + }, { + "val" : "ZFA:0000706" + }, { + "val" : "galen:Colon" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001159", + "lbl" : "sigmoid colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity.", + "xrefs" : [ "Wikipedia:Sigmoid_colon" ] + }, + "xrefs" : [ { + "val" : "BTO:0000645" + }, { + "val" : "CALOHA:TS-2044" + }, { + "val" : "EFO:0000846" + }, { + "val" : "EMAPA:36391" + }, { + "val" : "FMA:14548" + }, { + "val" : "MAT:0000314" + }, { + "val" : "MESH:D012809" + }, { + "val" : "MIAA:0000314" + }, { + "val" : "NCIT:C12384" + }, { + "val" : "NCIT:C33550" + }, { + "val" : "SCTID:362166007" + }, { + "val" : "Wikipedia:Sigmoid_colon" + }, { + "val" : "galen:SigmoidColon" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001161", + "lbl" : "body of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO].", + "xrefs" : [ "GO:0014845", "Wikipedia:Body_of_stomach" ] + }, + "xrefs" : [ { + "val" : "BTO:0000505" + }, { + "val" : "EMAPA:35810" + }, { + "val" : "FMA:14560" + }, { + "val" : "MA:0002559" + }, { + "val" : "NCIT:C12258" + }, { + "val" : "SCTID:362140009" + }, { + "val" : "Wikipedia:Body_of_stomach" + }, { + "val" : "galen:GastricCorpus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "lbl" : "pyloric antrum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010790" ] + }, + "xrefs" : [ { + "val" : "BTO:0001732" + }, { + "val" : "EFO:0002555" + }, { + "val" : "EMAPA:17891" + }, { + "val" : "FMA:14579" + }, { + "val" : "GAID:332" + }, { + "val" : "MA:0001624" + }, { + "val" : "MESH:D011706" + }, { + "val" : "NCIT:C12259" + }, { + "val" : "SCTID:362142001" + }, { + "val" : "Wikipedia:Pyloric_antrum" + }, { + "val" : "galen:PyloricAntrum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "lbl" : "pylorus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum.", + "xrefs" : [ "MGI:csmith", "MP:0010785" ] + }, + "xrefs" : [ { + "val" : "BTO:0001146" + }, { + "val" : "EHDAA2:0001580" + }, { + "val" : "EHDAA:4860" + }, { + "val" : "EMAPA:17631" + }, { + "val" : "FMA:14581" + }, { + "val" : "GAID:333" + }, { + "val" : "MA:0002560" + }, { + "val" : "MESH:D011708" + }, { + "val" : "NCIT:C12260" + }, { + "val" : "SCTID:362143006" + }, { + "val" : "VHOG:0000420" + }, { + "val" : "Wikipedia:Pylorus" + }, { + "val" : "galen:Pylorus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001167", + "lbl" : "wall of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between.", + "xrefs" : [ "MGI:csmith", "MP:0010783" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35826" + }, { + "val" : "FMA:14582" + }, { + "val" : "MA:0002692" + }, { + "val" : "SCTID:279995000" + }, { + "val" : "galen:WallOfStomach" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001168", + "lbl" : "wall of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of a small intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35785" + }, { + "val" : "FMA:14615" + }, { + "val" : "MA:0002696" + }, { + "val" : "NCIT:C33573" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001169", + "lbl" : "wall of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35470" + }, { + "val" : "FMA:14619" + }, { + "val" : "MA:0002695" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001170", + "lbl" : "mesentery of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP].", + "xrefs" : [ "Wikipedia:Mesentery#Mesentery_.28proper.29" ] + }, + "xrefs" : [ { + "val" : "FMA:14643" + }, { + "val" : "MA:0001555" + }, { + "val" : "SCTID:245456008" + }, { + "val" : "Wikipedia:Mesentery#Mesentery_.28proper.29" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001171", + "lbl" : "portal lobule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel.", + "xrefs" : [ "MP:0008992" ] + }, + "xrefs" : [ { + "val" : "FMA:14653" + }, { + "val" : "MA:0002498" + }, { + "val" : "NCIT:C33341" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "lbl" : "hepatic acinus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_acinus.html" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35497" + }, { + "val" : "FMA:14654" + }, { + "val" : "MA:0002496" + }, { + "val" : "NCIT:C32992" + }, { + "val" : "SCTID:272214009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "lbl" : "biliary tree", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder.", + "xrefs" : [ "DOI:10.1002/ar.20664" ] + }, + "comments" : [ "The path in many species is as follows: Bile canaliculi -> Canals of Hering (intralobar bile duct) -> interlobular bile ducts -> intrahepatic bile ducts -> left and right hepatic ducts merge to form -> common hepatic duct *exits liver* and joins -> cystic duct (from gall bladder) forming -> common bile duct -> joins with pancreatic duct -> forming ampulla of Vater -> enters duodenum [WP]" ], + "xrefs" : [ { + "val" : "AAO:0011020" + }, { + "val" : "EMAPA:35172" + }, { + "val" : "FMA:14665" + }, { + "val" : "SCTID:181267003" + }, { + "val" : "Wikipedia:Biliary_tract" + }, { + "val" : "XAO:0000455" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001174", + "lbl" : "common bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct.", + "xrefs" : [ "MGI:csmith", "MP:0009495" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000303" + }, { + "val" : "EHDAA:3981" + }, { + "val" : "EMAPA:17201" + }, { + "val" : "FMA:14667" + }, { + "val" : "GAID:282" + }, { + "val" : "MA:0001631" + }, { + "val" : "MESH:D003135" + }, { + "val" : "NCIT:C12698" + }, { + "val" : "SCTID:362199009" + }, { + "val" : "TAO:0005165" + }, { + "val" : "VHOG:0000214" + }, { + "val" : "Wikipedia:Common_bile_duct" + }, { + "val" : "ZFA:0005165" + }, { + "val" : "galen:CommonBileDuct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "lbl" : "common hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP].", + "xrefs" : [ "Wikipedia:Common_hepatic_duct", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19101" + }, { + "val" : "FMA:14668" + }, { + "val" : "GAID:286" + }, { + "val" : "MA:0002660" + }, { + "val" : "MESH:D006500" + }, { + "val" : "NCIT:C32356" + }, { + "val" : "SCTID:245403006" + }, { + "val" : "VHOG:0000220" + }, { + "val" : "Wikipedia:Common_hepatic_duct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001176", + "lbl" : "right hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct.", + "xrefs" : [ "http://www.medterms.com/script/main/art.asp?articlekey=26034" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001727" + }, { + "val" : "EHDAA:3992" + }, { + "val" : "EMAPA:32797" + }, { + "val" : "FMA:14669" + }, { + "val" : "MA:0001639" + }, { + "val" : "NCIT:C33476" + }, { + "val" : "SCTID:245401008" + }, { + "val" : "VHOG:0000217" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001177", + "lbl" : "left hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct.", + "xrefs" : [ "http://www.medterms.com/script/main/art.asp?articlekey=26035" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000941" + }, { + "val" : "EHDAA:3990" + }, { + "val" : "EMAPA:32795" + }, { + "val" : "FMA:14670" + }, { + "val" : "MA:0001638" + }, { + "val" : "NCIT:C32960" + }, { + "val" : "SCTID:245400009" + }, { + "val" : "VHOG:0000218" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001178", + "lbl" : "visceral peritoneum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space.", + "xrefs" : [ "Wikipedia:Peritoneum#Types", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16592" + }, { + "val" : "FMA:14703" + }, { + "val" : "SCTID:362702003" + }, { + "val" : "TAO:0005132" + }, { + "val" : "VHOG:0001528" + }, { + "val" : "Wikipedia:Visceral_peritoneum" + }, { + "val" : "ZFA:0005132" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001179", + "lbl" : "peritoneal cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cavity bounded by visceral and parietal peritoneum.", + "xrefs" : [ "Wikipedia:Peritoneal_cavity", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "BTO:0001782" + }, { + "val" : "EHDAA2:0001446" + }, { + "val" : "EMAPA:16138" + }, { + "val" : "FMA:14704" + }, { + "val" : "GAID:24" + }, { + "val" : "MA:0000054" + }, { + "val" : "MESH:D010529" + }, { + "val" : "NCIT:C12769" + }, { + "val" : "SCTID:181616008" + }, { + "val" : "VHOG:0000852" + }, { + "val" : "Wikipedia:Peritoneal_cavity" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001190", + "lbl" : "ovarian artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that supplies an ovary.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18620" + }, { + "val" : "FMA:14761" + }, { + "val" : "MA:0002012" + }, { + "val" : "NCIT:C33242" + }, { + "val" : "SCTID:244280002" + }, { + "val" : "Wikipedia:Ovarian_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001193", + "lbl" : "hepatic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that supplies the liver.", + "xrefs" : [ "Wikipedia:Hepatic_artery_proper", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004307" + }, { + "val" : "EMAPA:17859" + }, { + "val" : "FMA:14769" + }, { + "val" : "GAID:496" + }, { + "val" : "MA:0001963" + }, { + "val" : "MESH:D006499" + }, { + "val" : "NCIT:C32729" + }, { + "val" : "SCTID:76015000" + }, { + "val" : "TAO:0005161" + }, { + "val" : "ZFA:0005161" + }, { + "val" : "galen:HepaticArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001194", + "lbl" : "splenic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that supplies the spleen.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19216" + }, { + "val" : "FMA:14773" + }, { + "val" : "GAID:510" + }, { + "val" : "MA:0001991" + }, { + "val" : "MA:0003177" + }, { + "val" : "MESH:D013157" + }, { + "val" : "NCIT:C33597" + }, { + "val" : "SCTID:244266009" + }, { + "val" : "Wikipedia:Splenic_artery" + }, { + "val" : "galen:SplenicArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001199", + "lbl" : "mucosa of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The mucosal layer that lines the stomach.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001308" + }, { + "val" : "CALOHA:TS-0404" + }, { + "val" : "EMAPA:35817" + }, { + "val" : "FMA:14907" + }, { + "val" : "GAID:321" + }, { + "val" : "MA:0002683" + }, { + "val" : "MESH:D005753" + }, { + "val" : "NCIT:C32656" + }, { + "val" : "SCTID:362131005" + }, { + "val" : "Wikipedia:Gastric_mucosa" + }, { + "val" : "galen:GastricMucosa" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001200", + "lbl" : "submucosa of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The fibrous connective tissue layer beneath the stomach mucosa.", + "xrefs" : [ "MGI:csmith", "MP:0010794" ] + }, + "xrefs" : [ { + "val" : "BTO:0002110" + }, { + "val" : "EMAPA:35825" + }, { + "val" : "FMA:14908" + }, { + "val" : "MA:0002685" + }, { + "val" : "NCIT:C32663" + }, { + "val" : "SCTID:52459002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001201", + "lbl" : "serosa of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum.", + "xrefs" : [ "MGI:csmith", "MP:0010793" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35822" + }, { + "val" : "FMA:14914" + }, { + "val" : "MA:0001626" + }, { + "val" : "NCIT:C32662" + }, { + "val" : "SCTID:1353004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "lbl" : "pyloric sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP].", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011093" + }, { + "val" : "EMAPA:19251" + }, { + "val" : "FMA:14916" + }, { + "val" : "MA:0002952" + }, { + "val" : "NCIT:C33433" + }, { + "val" : "SCTID:268073008" + }, { + "val" : "VHOG:0001466" + }, { + "val" : "XAO:0000457" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001204", + "lbl" : "mucosa of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a small intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001259" + }, { + "val" : "CALOHA:TS-0941" + }, { + "val" : "EMAPA:35780" + }, { + "val" : "FMA:14933" + }, { + "val" : "MA:0002686" + }, { + "val" : "NCIT:C33568" + }, { + "val" : "SCTID:362144000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001205", + "lbl" : "submucosa of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Submucosal tissue in the small intestines.", + "xrefs" : [ "Wikipedia:Small_intestinal_submucosa" ] + }, + "xrefs" : [ { + "val" : "BTO:0002112" + }, { + "val" : "FMA:14934" + }, { + "val" : "MA:0001562" + }, { + "val" : "NCIT:C33572" + }, { + "val" : "SCTID:691000" + }, { + "val" : "Wikipedia:Small_intestinal_submucosa" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001206", + "lbl" : "serosa of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a small intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14938" + }, { + "val" : "MA:0001558" + }, { + "val" : "SCTID:8266009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001207", + "lbl" : "mucosa of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2106" + }, { + "val" : "EMAPA:35467" + }, { + "val" : "FMA:14969" + }, { + "val" : "MA:0002688" + }, { + "val" : "NCIT:C32926" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001208", + "lbl" : "submucosa of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002111" + }, { + "val" : "FMA:14970" + }, { + "val" : "MA:0002690" + }, { + "val" : "NCIT:C32930" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001209", + "lbl" : "serosa of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14975" + }, { + "val" : "MA:0001546" + }, { + "val" : "NCIT:C32929" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "lbl" : "duodenal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP].", + "xrefs" : [ "Wikipedia:Brunner's_glands" ] + }, + "xrefs" : [ { + "val" : "BTO:0002376" + }, { + "val" : "EMAPA:36522" + }, { + "val" : "FMA:15060" + }, { + "val" : "GAID:314" + }, { + "val" : "MA:0001551" + }, { + "val" : "MESH:D002011" + }, { + "val" : "NCIT:C13010" + }, { + "val" : "SCTID:41298001" + }, { + "val" : "Wikipedia:Brunner's_glands" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001213", + "lbl" : "intestinal villus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold.", + "xrefs" : [ "MGI:csmith", "MGI:rbabiuk", "MP:0008108" ] + }, + "xrefs" : [ { + "val" : "BTO:0003121" + }, { + "val" : "EMAPA:35784" + }, { + "val" : "FMA:15072" + }, { + "val" : "MA:0001563" + }, { + "val" : "NCIT:C33874" + }, { + "val" : "SCTID:23230007" + }, { + "val" : "TAO:0005125" + }, { + "val" : "Wikipedia:Intestinal_villus" + }, { + "val" : "ZFA:0005125" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001215", + "lbl" : "inferior mesenteric vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Inferior_mesenteric_vein" ] + }, + "xrefs" : [ { + "val" : "BTO:0002782" + }, { + "val" : "EHDAA2:0000819" + }, { + "val" : "EHDAA:8712" + }, { + "val" : "EMAPA:18642" + }, { + "val" : "FMA:15391" + }, { + "val" : "MA:0002178" + }, { + "val" : "NCIT:C32782" + }, { + "val" : "SCTID:281055007" + }, { + "val" : "VHOG:0001118" + }, { + "val" : "Wikipedia:Inferior_mesenteric_vein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001238", + "lbl" : "lamina propria of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lamina propria that is part_of the small intestine.", + "xrefs" : [ "GOC:Obol" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35779" + }, { + "val" : "FMA:15651" + }, { + "val" : "MA:0001554" + }, { + "val" : "NCIT:C49297" + }, { + "val" : "SCTID:63588008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001242", + "lbl" : "intestinal mucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mucosal layer that lines the intestine.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "BTO:0000642" + }, { + "val" : "EMAPA:35440" + }, { + "val" : "FMA:15695" + }, { + "val" : "GAID:296" + }, { + "val" : "MA:0001537" + }, { + "val" : "MESH:D007413" + }, { + "val" : "NCIT:C49241" + }, { + "val" : "SCTID:362080002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001243", + "lbl" : "serosa of intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a wall of intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15701" + }, { + "val" : "MA:0001538" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "lbl" : "anus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts.", + "xrefs" : [ "Wikipedia:Anus", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "BTO:0001680" + }, { + "val" : "CALOHA:TS-2005" + }, { + "val" : "EV:0100082" + }, { + "val" : "FMA:15711" + }, { + "val" : "GAID:312" + }, { + "val" : "MA:0000331" + }, { + "val" : "NCIT:C43362" + }, { + "val" : "SCTID:181262009" + }, { + "val" : "TADS:0000066" + }, { + "val" : "TGMA:0001279" + }, { + "val" : "WBbt:0005364" + }, { + "val" : "Wikipedia:Anus" + }, { + "val" : "galen:Anus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "lbl" : "interlobular bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad.", + "xrefs" : [ "MP:0009500" ] + }, + "xrefs" : [ { + "val" : "FMA:15767" + }, { + "val" : "MA:0002668" + }, { + "val" : "NCIT:C32827" + }, { + "val" : "SCTID:83488001" + }, { + "val" : "Wikipedia:Interlobular_bile_ducts" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001262", + "lbl" : "wall of intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of a intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000647" + }, { + "val" : "EMAPA:35444" + }, { + "val" : "FMA:15949" + }, { + "val" : "MA:0001525" + }, { + "val" : "MA:0002693" + }, { + "val" : "NCIT:C49478" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "lbl" : "pancreatic acinus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct.", + "xrefs" : [ "MP:0009145" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35651" + }, { + "val" : "FMA:16011" + }, { + "val" : "MA:0002417" + }, { + "val" : "NCIT:C49268" + }, { + "val" : "SCTID:247604006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "lbl" : "pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO].", + "xrefs" : [ "GO:0031016" ] + }, + "xrefs" : [ { + "val" : "AAO:0010112" + }, { + "val" : "BTO:0000988" + }, { + "val" : "CALOHA:TS-0736" + }, { + "val" : "EFO:0000855" + }, { + "val" : "EHDAA2:0001367" + }, { + "val" : "EHDAA:6893" + }, { + "val" : "EMAPA:17503" + }, { + "val" : "EV:0100092" + }, { + "val" : "FMA:7198" + }, { + "val" : "GAID:334" + }, { + "val" : "MA:0000120" + }, { + "val" : "MAT:0000075" + }, { + "val" : "MESH:D010179" + }, { + "val" : "MIAA:0000075" + }, { + "val" : "NCIT:C12393" + }, { + "val" : "SCTID:181277001" + }, { + "val" : "TAO:0000140" + }, { + "val" : "VHOG:0000050" + }, { + "val" : "Wikipedia:Pancreas" + }, { + "val" : "XAO:0000136" + }, { + "val" : "ZFA:0000140" + }, { + "val" : "galen:Pancreas" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001265", + "lbl" : "trabecula of spleen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A trabecula that is part of a spleen.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35808" + }, { + "val" : "FMA:16027" + }, { + "val" : "MA:0000758" + }, { + "val" : "NCIT:C33607" + }, { + "val" : "SCTID:61987002" + }, { + "val" : "Wikipedia:Trabeculae_of_spleen" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001268", + "lbl" : "peritoneal fluid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Transudate contained in the peritoneal cavity.", + "xrefs" : [ "FMA:16515" ] + }, + "xrefs" : [ { + "val" : "BTO:0001031" + }, { + "val" : "EMAPA:35683" + }, { + "val" : "FMA:16515" + }, { + "val" : "MA:0002531" + }, { + "val" : "Wikipedia:Peritoneal_fluid" + }, { + "val" : "ncithesaurus:Peritoneal_Fluid" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001276", + "lbl" : "epithelium of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial layer of the stomach .", + "xrefs" : [ "MP:0000471" ] + }, + "xrefs" : [ { + "val" : "BTO:0000500" + }, { + "val" : "CALOHA:TS-2068" + }, { + "val" : "EHDAA2:0001918" + }, { + "val" : "EMAPA:17023" + }, { + "val" : "FMA:17091" + }, { + "val" : "MA:0001610" + }, { + "val" : "SCTID:64977002" + }, { + "val" : "VHOG:0001433" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "lbl" : "intestinal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial layer that lines the intestine.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "BTO:0000781" + }, { + "val" : "EMAPA:32873" + }, { + "val" : "FMA:17229" + }, { + "val" : "MA:0001536" + }, { + "val" : "NCIT:C49240" + }, { + "val" : "SCTID:266135004" + }, { + "val" : "TAO:0005124" + }, { + "val" : "Wikipedia:Intestinal_epithelium" + }, { + "val" : "ZFA:0005124" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001278", + "lbl" : "epithelium of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2105" + }, { + "val" : "EMAPA:35466" + }, { + "val" : "FMA:17301" + }, { + "val" : "MA:0001545" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "lbl" : "portal triad", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:csmith", "MP:0008993", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:17523" + }, { + "val" : "MA:0002499" + }, { + "val" : "NCIT:C33342" + }, { + "val" : "SCTID:362192000" + }, { + "val" : "Wikipedia:Portal_triad" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "lbl" : "liver parenchyma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The functional units of the liver including the lobules.", + "xrefs" : [ "MP:0008986" ] + }, + "xrefs" : [ { + "val" : "AAO:0010405" + }, { + "val" : "EHDAA2:0001004" + }, { + "val" : "EHDAA:2201" + }, { + "val" : "EMAPA:17203" + }, { + "val" : "FMA:17540" + }, { + "val" : "MA:0000366" + }, { + "val" : "NCIT:C32735" + }, { + "val" : "SCTID:363535004" + }, { + "val" : "UMLS:C0736268" + }, { + "val" : "VHOG:0000539" + }, { + "val" : "XAO:0000454" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "lbl" : "hepatic sinusoid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers.", + "xrefs" : [ "Wikipedia:Hepatic_sinusoid", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000999" + }, { + "val" : "EMAPA:17365" + }, { + "val" : "FMA:17543" + }, { + "val" : "MA:0000367" + }, { + "val" : "NCIT:C32733" + }, { + "val" : "SCTID:67435004" + }, { + "val" : "TAO:0005091" + }, { + "val" : "VHOG:0000708" + }, { + "val" : "Wikipedia:Hepatic_sinusoid" + }, { + "val" : "ZFA:0005091" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "lbl" : "intralobular bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule.", + "xrefs" : [ "MGI:csmith", "MP:0009499" ] + }, + "xrefs" : [ { + "val" : "FMA:17545" + }, { + "val" : "MA:0002669" + }, { + "val" : "NCIT:C32255" + }, { + "val" : "SCTID:227002" + }, { + "val" : "SCTID:269922006" + }, { + "val" : "Wikipedia:Canals_of_Hering" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001353", + "lbl" : "anal region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The anus and surrounding regions. Encompasses both internal and external regions, where present.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EFO:0000847" + }, { + "val" : "EHDAA2:0000122" + }, { + "val" : "EHDAA:2931" + }, { + "val" : "EMAPA:16831" + }, { + "val" : "MA:0000329" + }, { + "val" : "MAT:0000042" + }, { + "val" : "MIAA:0000042" + }, { + "val" : "NCIT:C32069" + }, { + "val" : "SCTID:362680001" + }, { + "val" : "VHOG:0000395" + }, { + "val" : "WBbt:0006919" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001366", + "lbl" : "parietal peritoneum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outer layer of peritoneum that is attached to the abdominal and pelvic walls.", + "xrefs" : [ "Wikipedia:Peritoneum#Types", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010816" + }, { + "val" : "EMAPA:16591" + }, { + "val" : "FMA:21451" + }, { + "val" : "SCTID:362700006" + }, { + "val" : "TAO:0005131" + }, { + "val" : "VHOG:0001527" + }, { + "val" : "Wikipedia:Parietal_peritoneum" + }, { + "val" : "ZFA:0005131" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001416", + "lbl" : "skin of abdomen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of an abdomen [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0000214" + }, { + "val" : "FMA:22988" + }, { + "val" : "FMA:23000" + }, { + "val" : "MA:0000523" + }, { + "val" : "NCIT:C52758" + }, { + "val" : "SCTID:361707007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001417", + "lbl" : "skin of neck", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:23021" + }, { + "val" : "FMA:23022" + }, { + "val" : "MA:0000590" + }, { + "val" : "NCIT:C52756" + }, { + "val" : "SCTID:361705004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001418", + "lbl" : "skin of thorax", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:23028" + }, { + "val" : "FMA:23029" + }, { + "val" : "MA:0000564" + }, { + "val" : "SCTID:281723000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001421", + "lbl" : "pectoral girdle region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions.", + "xrefs" : [ "FMA:23217", "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:23217" + }, { + "val" : "SCTID:229759004" + }, { + "val" : "VSAO:0000305" + }, { + "val" : "galen:ShoulderGirdle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001434", + "lbl" : "skeletal system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000027", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AAO:0000566" + }, { + "val" : "BTO:0001486" + }, { + "val" : "CALOHA:TS-1320" + }, { + "val" : "EFO:0000806" + }, { + "val" : "EHDAA2:0003168" + }, { + "val" : "EMAPA:35773" + }, { + "val" : "FMA:23881" + }, { + "val" : "MA:0000018" + }, { + "val" : "NCIT:C12788" + }, { + "val" : "TAO:0000434" + }, { + "val" : "VHOG:0001254" + }, { + "val" : "VSAO:0000027" + }, { + "val" : "XAO:0003060" + }, { + "val" : "ZFA:0000434" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001444", + "lbl" : "subdivision of head", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:24218" + }, { + "val" : "SCTID:123852005" + }, { + "val" : "XAO:0000040" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001456", + "lbl" : "face", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0003369" + }, { + "val" : "CALOHA:TS-2216" + }, { + "val" : "EMAPA:32763" + }, { + "val" : "FMA:24728" + }, { + "val" : "GAID:64" + }, { + "val" : "HAO:0000316" + }, { + "val" : "MA:0002473" + }, { + "val" : "MESH:D005145" + }, { + "val" : "NCIT:C13071" + }, { + "val" : "SCTID:302549007" + }, { + "val" : "Wikipedia:Face" + }, { + "val" : "galen:Face" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001458", + "lbl" : "skin of lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a lip [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:24764" + }, { + "val" : "MA:0001579" + }, { + "val" : "NCIT:C12291" + }, { + "val" : "SCTID:244092005" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001474", + "lbl" : "bone element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal element that is composed of bone tissue.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000057", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/277" ] + }, + "xrefs" : [ { + "val" : "AAO:0000047" + }, { + "val" : "AEO:0000082" + }, { + "val" : "BTO:0000140" + }, { + "val" : "CALOHA:TS-0088" + }, { + "val" : "EFO:0000298" + }, { + "val" : "EHDAA2:0003082" + }, { + "val" : "EMAPA:32782" + }, { + "val" : "ENVO:00002039" + }, { + "val" : "EV:0100140" + }, { + "val" : "FMA:30317" + }, { + "val" : "FMA:5018" + }, { + "val" : "GAID:92" + }, { + "val" : "MA:0001459" + }, { + "val" : "MAT:0000299" + }, { + "val" : "MIAA:0000299" + }, { + "val" : "NCIT:C12366" + }, { + "val" : "SCTID:90780006" + }, { + "val" : "TAO:0001514" + }, { + "val" : "VHOG:0001190" + }, { + "val" : "VSAO:0000057" + }, { + "val" : "Wikipedia:Bone" + }, { + "val" : "XAO:0000169" + }, { + "val" : "ZFA:0001514" + }, { + "val" : "galen:Bone" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001484", + "lbl" : "articular capsule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Articular_capsule" ] + }, + "xrefs" : [ { + "val" : "FMA:34836" + }, { + "val" : "GAID:263" + }, { + "val" : "MA:0001519" + }, { + "val" : "MESH:D017746" + }, { + "val" : "NCIT:C32259" + }, { + "val" : "NCIT:C84388" + }, { + "val" : "SCTID:182238002" + }, { + "val" : "Wikipedia:Articular_capsule" + }, { + "val" : "galen:JointCapsule" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001496", + "lbl" : "ascending aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia].", + "xrefs" : [ "GO:0035905", "Wikipedia:Ascending_aorta" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000147" + }, { + "val" : "EHDAA:9828" + }, { + "val" : "EMAPA:17014" + }, { + "val" : "FMA:3736" + }, { + "val" : "MA:0002570" + }, { + "val" : "NCIT:C32150" + }, { + "val" : "SCTID:181299009" + }, { + "val" : "Wikipedia:Ascending_aorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001508", + "lbl" : "arch of aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0004113" ] + }, + "xrefs" : [ { + "val" : "BTO:0000157" + }, { + "val" : "EFO:0002526" + }, { + "val" : "EHDAA2:0000132" + }, { + "val" : "EMAPA:17613" + }, { + "val" : "FMA:3768" + }, { + "val" : "GAID:471" + }, { + "val" : "MA:0000475" + }, { + "val" : "SCTID:181300001" + }, { + "val" : "VHOG:0001196" + }, { + "val" : "Wikipedia:Arch_of_aorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001514", + "lbl" : "descending aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted].", + "xrefs" : [ "GO:0035906", "Wikipedia:Descending_aorta" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18606" + }, { + "val" : "FMA:3784" + }, { + "val" : "MA:0002571" + }, { + "val" : "NCIT:C32455" + }, { + "val" : "SCTID:261399002" + }, { + "val" : "Wikipedia:Descending_aorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001515", + "lbl" : "thoracic aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.", + "xrefs" : [ "MP:0010468", "http://www.medterms.com" ] + }, + "xrefs" : [ { + "val" : "BTO:0000157" + }, { + "val" : "EFO:0002525" + }, { + "val" : "EMAPA:18603" + }, { + "val" : "FMA:3786" + }, { + "val" : "GAID:471" + }, { + "val" : "MA:0002569" + }, { + "val" : "MESH:D001013" + }, { + "val" : "NCIT:C33766" + }, { + "val" : "SCTID:302510009" + }, { + "val" : "Wikipedia:Thoracic_aorta" + }, { + "val" : "galen:ThoracicAorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001516", + "lbl" : "abdominal aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted].", + "xrefs" : [ "BTO:0002976", "Wikipedia:Abdominal_aorta" ] + }, + "xrefs" : [ { + "val" : "BTO:0002976" + }, { + "val" : "EFO:0002524" + }, { + "val" : "EMAPA:17856" + }, { + "val" : "FMA:3789" + }, { + "val" : "GAID:470" + }, { + "val" : "MA:0000474" + }, { + "val" : "MESH:D001012" + }, { + "val" : "NCIT:C32038" + }, { + "val" : "SCTID:244231007" + }, { + "val" : "Wikipedia:Abdominal_aorta" + }, { + "val" : "galen:AbdominalAorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001529", + "lbl" : "brachiocephalic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery.", + "xrefs" : [ "MGI:csmith", "MP:0010663" ] + }, + "xrefs" : [ { + "val" : "EFO:0002550" + }, { + "val" : "EHDAA2:0000835" + }, { + "val" : "EMAPA:17615" + }, { + "val" : "FMA:3932" + }, { + "val" : "GAID:476" + }, { + "val" : "MA:0001922" + }, { + "val" : "MESH:D016122" + }, { + "val" : "NCIT:C32814" + }, { + "val" : "SCTID:244244002" + }, { + "val" : "Wikipedia:Brachiocephalic_artery" + }, { + "val" : "galen:BrachioCephalicArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001530", + "lbl" : "common carotid artery plus branches", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm].", + "xrefs" : [ "Wikipedia:Common_carotid_artery" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0116" + }, { + "val" : "EHDAA2:0000217" + }, { + "val" : "EHDAA:7331" + }, { + "val" : "EMAPA:17855" + }, { + "val" : "FMA:3939" + }, { + "val" : "GAID:479" + }, { + "val" : "MA:0001926" + }, { + "val" : "MESH:D017536" + }, { + "val" : "NCIT:C32352" + }, { + "val" : "SCTID:362041005" + }, { + "val" : "VHOG:0000272" + }, { + "val" : "Wikipedia:Common_carotid_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001533", + "lbl" : "subclavian artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta.", + "xrefs" : [ "ISBN:0073040584", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010232" + }, { + "val" : "EHDAA2:0001933" + }, { + "val" : "EHDAA:4357" + }, { + "val" : "EMAPA:17617" + }, { + "val" : "FMA:3951" + }, { + "val" : "GAID:511" + }, { + "val" : "MA:0002045" + }, { + "val" : "MESH:D013348" + }, { + "val" : "NCIT:C33643" + }, { + "val" : "SCTID:265790007" + }, { + "val" : "TAO:0005086" + }, { + "val" : "Wikipedia:Subclavian_artery" + }, { + "val" : "XAO:0000365" + }, { + "val" : "ZFA:0005086" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001534", + "lbl" : "right subclavian artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The subclavian artery that supplies the right pectoral appendage.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004514" + }, { + "val" : "FMA:3953" + }, { + "val" : "MA:0002047" + }, { + "val" : "NCIT:C33490" + }, { + "val" : "SCTID:244246000" + }, { + "val" : "Wikipedia:Subclavian_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001555", + "lbl" : "digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tube extending from the mouth to the anus.", + "xrefs" : [ "Wikipedia:Talk:Human_gastrointestinal_tract", "https://github.com/geneontology/go-ontology/issues/7549" ] + }, + "xrefs" : [ { + "val" : "AAO:0010023" + }, { + "val" : "BILA:0000083" + }, { + "val" : "BTO:0000511" + }, { + "val" : "BTO:0000545" + }, { + "val" : "EHDAA2:0000726" + }, { + "val" : "EHDAA:518" + }, { + "val" : "EMAPA:16247" + }, { + "val" : "FMA:45615" + }, { + "val" : "MA:0000917" + }, { + "val" : "NCIT:C34082" + }, { + "val" : "TAO:0000112" + }, { + "val" : "TGMA:0001819" + }, { + "val" : "VHOG:0000309" + }, { + "val" : "WBbt:0005743" + }, { + "val" : "ZFA:0000112" + }, { + "val" : "galen:AlimentaryTract" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001558", + "lbl" : "lower respiratory tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified].", + "xrefs" : [ "Wikipedia:Lower_respiratory_tract", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001036" + }, { + "val" : "EMAPA:16738" + }, { + "val" : "FMA:45662" + }, { + "val" : "MA:0000435" + }, { + "val" : "SCTID:281488008" + }, { + "val" : "VHOG:0000382" + }, { + "val" : "Wikipedia:Lower_respiratory_tract" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001584", + "lbl" : "left subclavian artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The subclavian artery that supplies the left pectoral appendage.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:4694" + }, { + "val" : "MA:0002046" + }, { + "val" : "NCIT:C32972" + }, { + "val" : "SCTID:244245001" + }, { + "val" : "Wikipedia:Subclavian_artery" + } ] + } + }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0001585", "lbl" : "anterior vena cava", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart.", + "xrefs" : [ "Wikipedia:Superior_vena_cava", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0002683" + }, { + "val" : "EHDAA2:0001962" + }, { + "val" : "EHDAA:8726" + }, { + "val" : "EMAPA:18417" + }, { + "val" : "FMA:4720" + }, { + "val" : "GAID:549" + }, { + "val" : "MA:0000481" + }, { + "val" : "MESH:D014683" + }, { + "val" : "NCIT:C12816" + }, { + "val" : "SCTID:181368006" + }, { + "val" : "VHOG:0001195" + }, { + "val" : "Wikipedia:Superior_vena_cava" + }, { + "val" : "galen:SuperiorVenaCava" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001586", + "lbl" : "internal jugular vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Internal_jugular_vein" ] + }, + "xrefs" : [ { + "val" : "AAO:0010236" + }, { + "val" : "EHDAA2:0000877" + }, { + "val" : "EHDAA:5407" + }, { + "val" : "EMAPA:17620" + }, { + "val" : "FMA:4724" + }, { + "val" : "MA:0002157" + }, { + "val" : "NCIT:C32849" + }, { + "val" : "RETIRED_EHDAA2:0000878" + }, { + "val" : "SCTID:181372005" + }, { + "val" : "Wikipedia:Internal_jugular_vein" + }, { + "val" : "XAO:0000382" + }, { + "val" : "galen:InternalJugularVein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001592", + "lbl" : "bronchial vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Bronchial_veins" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36284" + }, { + "val" : "FMA:4749" + }, { + "val" : "MA:0002088" + }, { + "val" : "NCIT:C53031" + }, { + "val" : "SCTID:198293000" + }, { + "val" : "Wikipedia:Bronchial_veins" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001605", + "lbl" : "ciliary muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Ciliary_muscle" ] + }, + "xrefs" : [ { + "val" : "BTO:0000654" + }, { + "val" : "EMAPA:35240" + }, { + "val" : "FMA:49151" + }, { + "val" : "MA:0001269" + }, { + "val" : "NCIT:C32315" + }, { + "val" : "SCTID:280862009" + }, { + "val" : "Wikipedia:Ciliary_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001606", + "lbl" : "muscle of iris", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:49154" + }, { + "val" : "MA:0001287" + }, { + "val" : "SCTID:280888007" + }, { + "val" : "Wikipedia:Iris_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "lbl" : "sphincter pupillae", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphincter muscle that is part of the iris.", + "xrefs" : [ "Wikipedia:Iris_sphincter_muscle" ] + }, + "xrefs" : [ { + "val" : "BTO:0000656" + }, { + "val" : "EMAPA:35788" + }, { + "val" : "FMA:49157" + }, { + "val" : "MA:0001289" + }, { + "val" : "NCIT:C33586" + }, { + "val" : "SCTID:280889004" + }, { + "val" : "Wikipedia:Iris_sphincter_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "lbl" : "dilatator pupillae", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Iris_dilator_muscle" ] + }, + "xrefs" : [ { + "val" : "BTO:0001371" + }, { + "val" : "EMAPA:35286" + }, { + "val" : "FMA:49158" + }, { + "val" : "MA:0001288" + }, { + "val" : "NCIT:C32463" + }, { + "val" : "SCTID:280890008" + }, { + "val" : "Wikipedia:Iris_dilator_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001612", + "lbl" : "facial artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A branch of the external carotid artery that supplies structures of the face. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Facial_artery" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19213" + }, { + "val" : "FMA:49549" + }, { + "val" : "MA:0001950" + }, { + "val" : "NCIT:C32578" + }, { + "val" : "SCTID:181328007" + }, { + "val" : "Wikipedia:Facial_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001630", + "lbl" : "muscle organ", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO].", + "xrefs" : [ "GO:0007517" ] + }, + "xrefs" : [ { + "val" : "EV:0100146" + }, { + "val" : "FMA:5022" + }, { + "val" : "GAID:131" + }, { + "val" : "MA:0000015" + }, { + "val" : "SCTID:71616004" + }, { + "val" : "TAO:0005145" + }, { + "val" : "VHOG:0001245" + }, { + "val" : "XAO:0000172" + }, { + "val" : "ZFA:0005145" + }, { + "val" : "galen:Muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001637", + "lbl" : "artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition].", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AAO:0010211" + }, { + "val" : "AEO:0000208" + }, { + "val" : "BTO:0000573" + }, { + "val" : "CALOHA:TS-0054" + }, { + "val" : "EFO:0000814" + }, { + "val" : "EHDAA2:0003253" + }, { + "val" : "EMAPA:35147" + }, { + "val" : "EV:0100026" + }, { + "val" : "FMA:50720" + }, { + "val" : "GAID:468" + }, { + "val" : "MA:0000064" + }, { + "val" : "MAT:0000034" + }, { + "val" : "MESH:D001158" + }, { + "val" : "MIAA:0000034" + }, { + "val" : "NCIT:C12372" + }, { + "val" : "SCTID:362877004" + }, { + "val" : "TAO:0000005" + }, { + "val" : "VHOG:0001251" + }, { + "val" : "Wikipedia:Artery" + }, { + "val" : "XAO:0000114" + }, { + "val" : "ZFA:0000005" + }, { + "val" : "galen:Artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001638", + "lbl" : "vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the tubular branching vessels that carry blood from the capillaries toward the heart.", + "xrefs" : [ "Wikipedia:Vein" ] + }, + "xrefs" : [ { + "val" : "AAO:0010212" + }, { + "val" : "AEO:0000209" + }, { + "val" : "BTO:0000234" + }, { + "val" : "CALOHA:TS-1108" + }, { + "val" : "EFO:0000816" + }, { + "val" : "EHDAA2:0003254" + }, { + "val" : "EMAPA:35906" + }, { + "val" : "EV:0100031" + }, { + "val" : "FMA:50723" + }, { + "val" : "GAID:492" + }, { + "val" : "MA:0000067" + }, { + "val" : "MAT:0000037" + }, { + "val" : "MESH:D014680" + }, { + "val" : "MIAA:0000037" + }, { + "val" : "NCIT:C12814" + }, { + "val" : "SCTID:181367001" + }, { + "val" : "TAO:0000082" + }, { + "val" : "VHOG:0001743" + }, { + "val" : "Wikipedia:Vein" + }, { + "val" : "XAO:0000115" + }, { + "val" : "ZFA:0000082" + }, { + "val" : "galen:Vein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001639", + "lbl" : "hepatic portal vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portal vein that transports nutrients from the digestive tract to the liver[Kardong].", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Hepatic_portal_vein", "http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376" ] + }, + "xrefs" : [ { + "val" : "AAO:0010214" + }, { + "val" : "FMA:50735" + }, { + "val" : "MA:0002132" + }, { + "val" : "TAO:0005090" + }, { + "val" : "VHOG:0000642" + }, { + "val" : "Wikipedia:Hepatic_portal_vein" + }, { + "val" : "ZFA:0005090" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "lbl" : "celiac artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first major branch of the abdominal aorta.", + "xrefs" : [ "Wikipedia:Celiac_artery" ] + }, + "comments" : [ "dorsal aorta in Kardong" ], + "xrefs" : [ { + "val" : "EHDAA2:0004519" + }, { + "val" : "EMAPA:35202" + }, { + "val" : "FMA:50737" + }, { + "val" : "GAID:483" + }, { + "val" : "MA:0001931" + }, { + "val" : "MESH:D002445" + }, { + "val" : "NCIT:C52846" + }, { + "val" : "SCTID:181340007" + }, { + "val" : "Wikipedia:Celiac_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001645", + "lbl" : "trigeminal nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw).", + "xrefs" : [ "ISBN:0471209627", "Wikipedia:Trigeminal_nerve" ] + }, + "xrefs" : [ { + "val" : "AAO:0010470" + }, { + "val" : "BAMS:5n" + }, { + "val" : "BAMS:Vn" + }, { + "val" : "BAMS:nV" + }, { + "val" : "BIRNLEX:869" + }, { + "val" : "BM:VN" + }, { + "val" : "BTO:0001072" + }, { + "val" : "EFO:0001402" + }, { + "val" : "EHDAA2:0002084" + }, { + "val" : "EHDAA:3738" + }, { + "val" : "EMAPA:17576" + }, { + "val" : "FMA:50866" + }, { + "val" : "GAID:726" + }, { + "val" : "MA:0001100" + }, { + "val" : "MBA:901" + }, { + "val" : "MESH:D014276" + }, { + "val" : "MFMO:0000093" + }, { + "val" : "NCIT:C12806" + }, { + "val" : "SCTID:362459002" + }, { + "val" : "TAO:0000697" + }, { + "val" : "VHOG:0000704" + }, { + "val" : "Wikipedia:Trigeminal_nerve" + }, { + "val" : "XAO:0003092" + }, { + "val" : "ZFA:0000697" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001651", + "lbl" : "right pulmonary artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pulmonary artery that supplies the right lung.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:50872" + }, { + "val" : "MA:0002500" + }, { + "val" : "NCIT:C33489" + }, { + "val" : "SCTID:244235003" + }, { + "val" : "Wikipedia:Right_pulmonary_artery" + }, { + "val" : "galen:RightPulmonaryArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001652", + "lbl" : "left pulmonary artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pulmonary artery that supplies the left lung.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:50873" + }, { + "val" : "MA:0002032" + }, { + "val" : "NCIT:C32971" + }, { + "val" : "SCTID:244234004" + }, { + "val" : "Wikipedia:Left_pulmonary_artery" + }, { + "val" : "galen:LeftPulmonaryArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001653", + "lbl" : "facial vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Facial_vein" ] + }, + "xrefs" : [ { + "val" : "AAO:0010513" + }, { + "val" : "EMAPA:19220" + }, { + "val" : "FMA:50874" + }, { + "val" : "MA:0002115" + }, { + "val" : "NCIT:C32579" + }, { + "val" : "SCTID:181374006" + }, { + "val" : "Wikipedia:Facial_vein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001675", + "lbl" : "trigeminal ganglion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cranial ganglion that is associated with and extends fibers into the trigeminal nerve.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.ncbi.nlm.nih.gov/books/NBK53171", "https://github.com/obophenotype/uberon/issues/693" ] + }, + "xrefs" : [ { + "val" : "AAO:0011107" + }, { + "val" : "BAMS:5Gn" + }, { + "val" : "BAMS:GV" + }, { + "val" : "BTO:0001231" + }, { + "val" : "EFO:0000903" + }, { + "val" : "EHDAA2:0002085" + }, { + "val" : "EHDAA:2113" + }, { + "val" : "EMAPA:16797" + }, { + "val" : "FMA:52618" + }, { + "val" : "GAID:725" + }, { + "val" : "MA:0001080" + }, { + "val" : "MAT:0000511" + }, { + "val" : "MESH:D012668" + }, { + "val" : "NCIT:C62642" + }, { + "val" : "SCTID:244449009" + }, { + "val" : "TAO:0000295" + }, { + "val" : "VHOG:0000694" + }, { + "val" : "Wikipedia:Trigeminal_ganglion" + }, { + "val" : "XAO:0000427" + }, { + "val" : "XAO:0000428" + }, { + "val" : "ZFA:0000295" + }, { + "val" : "neuronames:1402" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001676", + "lbl" : "occipital bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bone at the lower, posterior part of the skull.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0005269" ] + }, + "xrefs" : [ { + "val" : "EMAPA:25112" + }, { + "val" : "FMA:52735" + }, { + "val" : "GAID:227" + }, { + "val" : "MA:0001468" + }, { + "val" : "MESH:D009777" + }, { + "val" : "NCIT:C12757" + }, { + "val" : "SCTID:181796003" + }, { + "val" : "Wikipedia:Occipital_bone" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "lbl" : "sphenoid bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended.", + "xrefs" : [ "Wikipedia:Sphenoid_bone" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2343" + }, { + "val" : "EMAPA:18340" + }, { + "val" : "FMA:52736" + }, { + "val" : "GAID:230" + }, { + "val" : "MA:0001472" + }, { + "val" : "MESH:D013100" + }, { + "val" : "NCIT:C12790" + }, { + "val" : "SCTID:272676008" + }, { + "val" : "Wikipedia:Sphenoid_bone" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "lbl" : "ethmoid bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP].", + "xrefs" : [ "Wikipedia:Ethmoid_bone" ] + }, + "xrefs" : [ { + "val" : "BTO:0004140" + }, { + "val" : "EMAPA:19018" + }, { + "val" : "FMA:52740" + }, { + "val" : "GAID:212" + }, { + "val" : "MA:0001483" + }, { + "val" : "MESH:D005004" + }, { + "val" : "NCIT:C12711" + }, { + "val" : "SCTID:272674006" + }, { + "val" : "VHOG:0001317" + }, { + "val" : "Wikipedia:Ethmoid_bone" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "lbl" : "orbit of skull", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball.", + "xrefs" : [ "TAO:0001410", "Wikipedia:Orbit_(anatomy)", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004687" + }, { + "val" : "FMA:53074" + }, { + "val" : "GAID:223" + }, { + "val" : "MA:0002482" + }, { + "val" : "MESH:D009915" + }, { + "val" : "NCIT:C12347" + }, { + "val" : "TAO:0001410" + }, { + "val" : "Wikipedia:Orbit_(anatomy)" + }, { + "val" : "XAO:0003171" + }, { + "val" : "ZFA:0001410" + }, { + "val" : "galen:Orbit" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001703", + "lbl" : "neurocranium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof.", + "xrefs" : [ "PMID:11523816", "TAO:MAH", "Wikipedia:Neuroranium", "ZFA:0001580" ] + }, + "xrefs" : [ { + "val" : "FMA:53672" + }, { + "val" : "MA:0000317" + }, { + "val" : "SCTID:361731002" + }, { + "val" : "TAO:0001580" + }, { + "val" : "Wikipedia:Neuroranium" + }, { + "val" : "XAO:0003170" + }, { + "val" : "ZFA:0001580" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001708", + "lbl" : "jaw skeleton", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skeleton which includes upper and lower jaw skeletons.", + "xrefs" : [ "Wikipedia:Jaw", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000988" + }, { + "val" : "BTO:0001749" + }, { + "val" : "EMAPA:35455" + }, { + "val" : "FMA:54396" + }, { + "val" : "GAID:214" + }, { + "val" : "MA:0001905" + }, { + "val" : "MESH:D007568" + }, { + "val" : "NCIT:C48821" + }, { + "val" : "SCTID:181811001" + }, { + "val" : "TAO:0001227" + }, { + "val" : "Wikipedia:Jaw" + }, { + "val" : "ZFA:0001227" + }, { + "val" : "galen:Jaw" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "lbl" : "upper jaw region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm].", + "xrefs" : [ "Wikipedia:Upper_jaw", "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "See notes for jaw w.r.t skeletal element vs subdivision of head." ], + "xrefs" : [ { + "val" : "AAO:0000620" + }, { + "val" : "EHDAA2:0002118" + }, { + "val" : "EHDAA2:0004607" + }, { + "val" : "EHDAA:8025" + }, { + "val" : "EMAPA:17924" + }, { + "val" : "FMA:59399" + }, { + "val" : "SCTID:362636001" + }, { + "val" : "VHOG:0000454" + }, { + "val" : "Wikipedia:Upper_jaw" + }, { + "val" : "ncithesaurus:Upper_Jaw" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001710", + "lbl" : "lower jaw region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm].", + "xrefs" : [ "Wikipedia:Lower_jaw" ] + }, + "comments" : [ "See notes for jaw w.r.t skeletal element vs subdivision of head" ], + "xrefs" : [ { + "val" : "AAO:0000272" + }, { + "val" : "EFO:0003660" + }, { + "val" : "EHDAA2:0001018" + }, { + "val" : "EHDAA:7995" + }, { + "val" : "EMAPA:17906" + }, { + "val" : "FMA:59398" + }, { + "val" : "MESH:D008334" + }, { + "val" : "SCTID:362637005" + }, { + "val" : "VHOG:0000453" + }, { + "val" : "Wikipedia:Lower_jaw" + }, { + "val" : "ncithesaurus:Lower_Jaw" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001714", + "lbl" : "cranial ganglion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The groups of nerve cell bodies associated with the twelve cranial nerves.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:csmith", "MP:0001081", "PMID:9362461" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:2597" + }, { + "val" : "BTO:0000106" + }, { + "val" : "EFO:0000902" + }, { + "val" : "EMAPA:16659" + }, { + "val" : "FMA:54502" + }, { + "val" : "MA:0000213" + }, { + "val" : "MA:0000214" + }, { + "val" : "MAT:0000200" + }, { + "val" : "MIAA:0000200" + }, { + "val" : "SCTID:244448001" + }, { + "val" : "TAO:0000013" + }, { + "val" : "VHOG:0000076" + }, { + "val" : "Wikipedia:Cranial_nerve_ganglion" + }, { + "val" : "XAO:0000027" + }, { + "val" : "ZFA:0000013" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001731", + "lbl" : "cavity of pharynx", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is enclosed by a pharynx.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0010435" + }, { + "val" : "BSA:0000113" + }, { + "val" : "BTO:0002097" + }, { + "val" : "EMAPA:18381" + }, { + "val" : "FMA:54935" + }, { + "val" : "SCTID:180543003" + }, { + "val" : "XAO:0000105" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001766", + "lbl" : "anterior chamber of eyeball", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens.", + "xrefs" : [ "MESH:A09.371.060.067", "MP:0005205" ] + }, + "xrefs" : [ { + "val" : "BTO:0002084" + }, { + "val" : "EHDAA2:0000129" + }, { + "val" : "EHDAA:9033" + }, { + "val" : "EMAPA:18231" + }, { + "val" : "FMA:58078" + }, { + "val" : "GAID:889" + }, { + "val" : "MA:0000262" + }, { + "val" : "MESH:D000867" + }, { + "val" : "NCIT:C12667" + }, { + "val" : "SCTID:181160009" + }, { + "val" : "VHOG:0001431" + }, { + "val" : "Wikipedia:Anterior_chamber_of_eyeball" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001768", + "lbl" : "uvea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited].", + "xrefs" : [ "MP:0005197", "Wikipedia:Uvea" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2228" + }, { + "val" : "EMAPA:35901" + }, { + "val" : "FMA:58103" + }, { + "val" : "GAID:912" + }, { + "val" : "MA:0002480" + }, { + "val" : "MESH:D014602" + }, { + "val" : "NCIT:C12811" + }, { + "val" : "SCTID:280648000" + }, { + "val" : "Wikipedia:Uvea" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001769", + "lbl" : "iris", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0001322" ] + }, + "xrefs" : [ { + "val" : "AAO:0010347" + }, { + "val" : "BTO:0000653" + }, { + "val" : "CALOHA:TS-0491" + }, { + "val" : "EFO:0004245" + }, { + "val" : "EMAPA:19154" + }, { + "val" : "EV:0100345" + }, { + "val" : "FMA:58235" + }, { + "val" : "GAID:917" + }, { + "val" : "MA:0000273" + }, { + "val" : "MESH:D007498" + }, { + "val" : "NCIT:C12737" + }, { + "val" : "SCTID:181164000" + }, { + "val" : "TAO:0001238" + }, { + "val" : "VHOG:0000101" + }, { + "val" : "Wikipedia:Iris_(anatomy)" + }, { + "val" : "XAO:0000185" + }, { + "val" : "ZFA:0001238" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001772", + "lbl" : "corneal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The smooth stratified squamous epithelium that covers the outer surface of the cornea.", + "xrefs" : [ "MESH:A09.371.060.217.325", "MGI:smb", "MP:0006000" ] + }, + "xrefs" : [ { + "val" : "BTO:0000287" + }, { + "val" : "CALOHA:TS-0173" + }, { + "val" : "EFO:0001917" + }, { + "val" : "EHDAA2:0000319" + }, { + "val" : "EMAPA:17162" + }, { + "val" : "FMA:58263" + }, { + "val" : "GAID:895" + }, { + "val" : "MA:0001243" + }, { + "val" : "MESH:D019573" + }, { + "val" : "NCIT:C12928" + }, { + "val" : "SCTID:368825001" + }, { + "val" : "TAO:0002187" + }, { + "val" : "Wikipedia:Corneal_epithelium" + }, { + "val" : "ZFA:0001683" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001773", + "lbl" : "sclera", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP].", + "xrefs" : [ "Wikipedia:Sclera", "ZFIN:ZDB-PUB-050701-15" ] + }, + "comments" : [ "Disease notes: implicated in rheumatoid arthritis." ], + "xrefs" : [ { + "val" : "AAO:0010354" + }, { + "val" : "BTO:0001606" + }, { + "val" : "EMAPA:19027" + }, { + "val" : "EV:0100342" + }, { + "val" : "FMA:58269" + }, { + "val" : "GAID:911" + }, { + "val" : "MA:0000280" + }, { + "val" : "MESH:D012590" + }, { + "val" : "NCIT:C12784" + }, { + "val" : "SCTID:181163006" + }, { + "val" : "VHOG:0001274" + }, { + "val" : "Wikipedia:Sclera" + }, { + "val" : "XAO:0000183" + }, { + "val" : "ZFA:0005563" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001774", + "lbl" : "skeletal muscle of trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal muscle organ that is part of the trunk region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000611" + }, { + "val" : "EMAPA:35888" + }, { + "val" : "FMA:58274" + }, { + "val" : "MA:0000514" + }, { + "val" : "TAO:0000473" + }, { + "val" : "XAO:0003230" + }, { + "val" : "ZFA:0000473" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001775", + "lbl" : "ciliary body", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0005099", "Wikipedia:Ciliary_body" ] + }, + "xrefs" : [ { + "val" : "AAO:0010341" + }, { + "val" : "BTO:0000260" + }, { + "val" : "CALOHA:TS-0694" + }, { + "val" : "EMAPA:19065" + }, { + "val" : "EV:0100346" + }, { + "val" : "FMA:58295" + }, { + "val" : "GAID:916" + }, { + "val" : "MA:0000264" + }, { + "val" : "MESH:D002924" + }, { + "val" : "NCIT:C12345" + }, { + "val" : "SCTID:263340007" + }, { + "val" : "VHOG:0000102" + }, { + "val" : "Wikipedia:Ciliary_body" + }, { + "val" : "XAO:0000186" + }, { + "val" : "neuronames:1571" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001776", + "lbl" : "optic choroid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP].", + "xrefs" : [ "Wikipedia:Choroid" ] + }, + "xrefs" : [ { + "val" : "BTO:0001829" + }, { + "val" : "CALOHA:TS-2054" + }, { + "val" : "EMAPA:19077" + }, { + "val" : "EV:0100347" + }, { + "val" : "FMA:58298" + }, { + "val" : "GAID:913" + }, { + "val" : "MA:0000263" + }, { + "val" : "MESH:D002829" + }, { + "val" : "NCIT:C12344" + }, { + "val" : "SCTID:181172003" + }, { + "val" : "TAO:0005229" + }, { + "val" : "VHOG:0001568" + }, { + "val" : "Wikipedia:Choroid" + }, { + "val" : "ZFA:0005229" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001777", + "lbl" : "substantia propria of cornea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lamellated connective tissue of the cornea between the Bowman and Descemet membranes.", + "xrefs" : [ "ISBN:0-683-40008-8", "MESH:A09.371.060.217.228", "MP:0005300" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1138" + }, { + "val" : "EFO:0002514" + }, { + "val" : "EMAPA:17602" + }, { + "val" : "FMA:58306" + }, { + "val" : "GAID:893" + }, { + "val" : "MA:0001245" + }, { + "val" : "MESH:D003319" + }, { + "val" : "NCIT:C12699" + }, { + "val" : "SCTID:362511000" + }, { + "val" : "TAO:0002189" + }, { + "val" : "Wikipedia:Corneal_stroma" + }, { + "val" : "ZFA:0001685" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001778", + "lbl" : "ciliary epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A double layer covering the ciliary body that produces aqueous humor.", + "xrefs" : [ "Wikipedia:Ciliary_body#Ciliary_epithelium" ] + }, + "xrefs" : [ { + "val" : "BTO:0001770" + }, { + "val" : "CALOHA:TS-0695" + }, { + "val" : "EMAPA:35239" + }, { + "val" : "FMA:58464" + }, { + "val" : "MA:0001238" + }, { + "val" : "NCIT:C32314" + }, { + "val" : "SCTID:280870004" + }, { + "val" : "Wikipedia:Ciliary_body#Ciliary_epithelium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001779", + "lbl" : "iris stroma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae.", + "xrefs" : [ "Wikipedia:Iris_stroma", "http://www.drugs.com/dict/stroma-of-iris.html" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35451" + }, { + "val" : "FMA:58526" + }, { + "val" : "MA:0002777" + }, { + "val" : "SCTID:280882008" + }, { + "val" : "Wikipedia:Iris_stroma" + }, { + "val" : "ZFA:0005569" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001780", + "lbl" : "spinal nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified].", + "xrefs" : [ "MESH:A08.800.800.720", "MP:0001077" ] + }, + "xrefs" : [ { + "val" : "AAO:0011101" + }, { + "val" : "BAMS:spin" + }, { + "val" : "BTO:0000870" + }, { + "val" : "EHDAA2:0001898" + }, { + "val" : "EMAPA:16989" + }, { + "val" : "FMA:5858" + }, { + "val" : "GAID:841" + }, { + "val" : "MA:0000233" + }, { + "val" : "MESH:D013127" + }, { + "val" : "NCIT:C12792" + }, { + "val" : "SCTID:361099009" + }, { + "val" : "VHOG:0000824" + }, { + "val" : "Wikipedia:Spinal_nerve" + }, { + "val" : "XAO:0003101" + }, { + "val" : "neuronames:1228" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001781", + "lbl" : "layer of retina", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the layers that make up the retina[MP].", + "xrefs" : [ "MP:0003727" ] + }, + "xrefs" : [ { + "val" : "AAO:0010353" + }, { + "val" : "EMAPA:35742" + }, { + "val" : "FMA:58617" + }, { + "val" : "MA:0001319" + }, { + "val" : "NCIT:C49328" + }, { + "val" : "SCTID:280657006" + }, { + "val" : "XAO:0000266" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001785", + "lbl" : "cranial nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord.", + "xrefs" : [ "Wikipedia:Cranial_nerve" ] + }, + "xrefs" : [ { + "val" : "AAO:0000108" + }, { + "val" : "BAMS:cran" + }, { + "val" : "BIRNLEX:1623" + }, { + "val" : "BTO:0001104" + }, { + "val" : "EHDAA2:0000323" + }, { + "val" : "EMAPA:17264" + }, { + "val" : "FMA:5865" + }, { + "val" : "GAID:802" + }, { + "val" : "MA:0000215" + }, { + "val" : "MBA:967" + }, { + "val" : "MESH:D003391" + }, { + "val" : "NCIT:C12700" + }, { + "val" : "SCTID:244447006" + }, { + "val" : "TAO:0000641" + }, { + "val" : "VHOG:0000279" + }, { + "val" : "Wikipedia:Cranial_nerve" + }, { + "val" : "XAO:0000429" + }, { + "val" : "XAO:0003089" + }, { + "val" : "ZFA:0000641" + }, { + "val" : "neuronames:1227" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001796", + "lbl" : "aqueous humor of eyeball", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thick watery refractive medium that fills the space between the lens and the cornea[WP].", + "xrefs" : [ "Wikipedia:Aqueous_humor" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000139" + }, { + "val" : "EHDAA:10196" + }, { + "val" : "EMAPA:18232" + }, { + "val" : "ENVO:02000024" + }, { + "val" : "FMA:58819" + }, { + "val" : "GAID:890" + }, { + "val" : "MA:0001236" + }, { + "val" : "MESH:D001082" + }, { + "val" : "NCIT:C13190" + }, { + "val" : "SCTID:280587006" + }, { + "val" : "VHOG:0000548" + }, { + "val" : "Wikipedia:Aqueous_humor" + }, { + "val" : "ZFA:0005564" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001800", + "lbl" : "sensory ganglion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells.", + "xrefs" : [ "MP:0000960" ] + }, + "xrefs" : [ { + "val" : "AEO:0001000" + }, { + "val" : "BTO:0005630" + }, { + "val" : "EMAPA:36596" + }, { + "val" : "FMA:5885" + }, { + "val" : "MA:0002566" + }, { + "val" : "MESH:D017950" + }, { + "val" : "NCIT:C13060" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001801", + "lbl" : "anterior segment of eyeball", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive).", + "xrefs" : [ "ISBN:0-683-40008-8", "MESH:A09.371.060", "MP:0005193" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36594" + }, { + "val" : "FMA:58865" + }, { + "val" : "MA:0002484" + }, { + "val" : "MESH:D000869" + }, { + "val" : "NCIT:C12668" + }, { + "val" : "SCTID:280658001" + }, { + "val" : "Wikipedia:Anterior_segment_of_eyeball" + }, { + "val" : "ZFA:0005566" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001802", + "lbl" : "posterior segment of eyeball", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive).", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0005195" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36595" + }, { + "val" : "FMA:58868" + }, { + "val" : "MA:0002485" + }, { + "val" : "NCIT:C12906" + }, { + "val" : "SCTID:280659009" + }, { + "val" : "Wikipedia:Posterior_segment_of_eyeball" + }, { + "val" : "ZFA:0005567" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001803", + "lbl" : "epithelium of lens", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of epithelial cells that is part of the eye.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001873" + }, { + "val" : "CALOHA:TS-0543" + }, { + "val" : "EMAPA:32871" + }, { + "val" : "FMA:58871" + }, { + "val" : "MA:0001301" + }, { + "val" : "SCTID:362523006" + }, { + "val" : "TAO:0001326" + }, { + "val" : "Wikipedia:Lens_(anatomy)#Lens_Epithelium" + }, { + "val" : "XAO:0004094" + }, { + "val" : "ZFA:0001326" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001804", + "lbl" : "capsule of lens", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The elastic, clear, membrane-like structure, that is outer most layer of the lens.", + "xrefs" : [ "MGI:smb", "MP:0003236", "PMID:15483628" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000977" + }, { + "val" : "EMAPA:18237" + }, { + "val" : "FMA:58881" + }, { + "val" : "MA:0001300" + }, { + "val" : "NCIT:C32975" + }, { + "val" : "SCTID:244500004" + }, { + "val" : "VHOG:0000550" + }, { + "val" : "Wikipedia:Lens_(anatomy)#Lens_capsule" + }, { + "val" : "ZFA:0005574" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001805", + "lbl" : "autonomic ganglion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion.", + "xrefs" : [ "Wikipedia:Autonomic_ganglion" ] + }, + "xrefs" : [ { + "val" : "AEO:0001001" + }, { + "val" : "CALOHA:TS-2340" + }, { + "val" : "EMAPA:18221" + }, { + "val" : "FMA:5889" + }, { + "val" : "MA:0000220" + }, { + "val" : "MESH:D005725" + }, { + "val" : "NCIT:C12720" + }, { + "val" : "Wikipedia:Autonomic_ganglion" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001806", + "lbl" : "sympathetic ganglion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.", + "xrefs" : [ "MP:0001008", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010773" + }, { + "val" : "BTO:0001333" + }, { + "val" : "CALOHA:TS-0994" + }, { + "val" : "EHDAA2:0001969" + }, { + "val" : "EMAPA:17157" + }, { + "val" : "FMA:5890" + }, { + "val" : "MA:0000226" + }, { + "val" : "NCIT:C12467" + }, { + "val" : "SCTID:362485003" + }, { + "val" : "Wikipedia:Sympathetic_ganglion" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001833", + "lbl" : "lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the two fleshy folds which surround the opening of the mouth.", + "xrefs" : [ "Wikipedia:Lip", "http://www.medterms.com/script/main/art.asp?articlekey=9458" ] + }, + "xrefs" : [ { + "val" : "BTO:0001647" + }, { + "val" : "CALOHA:TS-0558" + }, { + "val" : "EMAPA:32839" + }, { + "val" : "FMA:59816" + }, { + "val" : "GAID:76" + }, { + "val" : "MA:0000343" + }, { + "val" : "MESH:D008046" + }, { + "val" : "NCIT:C12220" + }, { + "val" : "SCTID:181221003" + }, { + "val" : "TAO:0007006" + }, { + "val" : "VHOG:0000677" + }, { + "val" : "Wikipedia:Lip" + }, { + "val" : "ZFA:0007006" + }, { + "val" : "galen:Lip" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001834", + "lbl" : "upper lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lip that covers the upper portion of the mouth.[TAO].", + "xrefs" : [ "TAO:0001970", "Wikipedia:Upper_lip" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17925" + }, { + "val" : "FMA:59817" + }, { + "val" : "MA:0000919" + }, { + "val" : "SCTID:245776003" + }, { + "val" : "TAO:0001970" + }, { + "val" : "VHOG:0001750" + }, { + "val" : "Wikipedia:Upper_lip" + }, { + "val" : "ZFA:0005226" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001835", + "lbl" : "lower lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lip that covers the lower portion of the mouth.[TAO].", + "xrefs" : [ "TAO:0002060", "Wikipedia:Lower_lip" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17909" + }, { + "val" : "FMA:59818" + }, { + "val" : "MA:0000921" + }, { + "val" : "NCIT:C94572" + }, { + "val" : "SCTID:245777007" + }, { + "val" : "TAO:0002060" + }, { + "val" : "Wikipedia:Lower_lip" + }, { + "val" : "ZFA:0005225" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001884", + "lbl" : "phrenic nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium.", + "xrefs" : [ "VHOG:0000728" ] + }, + "xrefs" : [ { + "val" : "BAMS:phn" + }, { + "val" : "BTO:0001063" + }, { + "val" : "EHDAA:4677" + }, { + "val" : "EMAPA:17813" + }, { + "val" : "FMA:6191" + }, { + "val" : "GAID:848" + }, { + "val" : "MA:0001170" + }, { + "val" : "MESH:D010791" + }, { + "val" : "NCIT:C52813" + }, { + "val" : "SCTID:280344009" + }, { + "val" : "VHOG:0000728" + }, { + "val" : "Wikipedia:Phrenic_nerve" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001891", + "lbl" : "midbrain", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO].", + "xrefs" : [ "GO:0030901" ] + }, + "xrefs" : [ { + "val" : "AAO:0010149" + }, { + "val" : "BAMS:MES" + }, { + "val" : "BIRNLEX:1667" + }, { + "val" : "BM:MB" + }, { + "val" : "BTO:0000138" + }, { + "val" : "CALOHA:TS-0630" + }, { + "val" : "DHBA:10648" + }, { + "val" : "DMBA:16649" + }, { + "val" : "EFO:0000919" + }, { + "val" : "EHDAA2:0001162" + }, { + "val" : "EHDAA:3694" + }, { + "val" : "EMAPA:16974" + }, { + "val" : "EV:0100242" + }, { + "val" : "FMA:61993" + }, { + "val" : "HBA:9001" + }, { + "val" : "MA:0000207" + }, { + "val" : "MAT:0000106" + }, { + "val" : "MBA:313" + }, { + "val" : "MESH:D008636" + }, { + "val" : "MIAA:0000106" + }, { + "val" : "NCIT:C12510" + }, { + "val" : "RETIRED_EHDAA2:0001104" + }, { + "val" : "SCTID:279099009" + }, { + "val" : "TAO:0000128" + }, { + "val" : "VHOG:0000069" + }, { + "val" : "Wikipedia:Midbrain" + }, { + "val" : "XAO:0000014" + }, { + "val" : "ZFA:0000128" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001892", + "lbl" : "rhombomere", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP].", + "xrefs" : [ "Wikipedia:Rhombomere", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "DHBA:12664" + }, { + "val" : "EFO:0003617" + }, { + "val" : "EMAPA:16148" + }, { + "val" : "FMA:295666" + }, { + "val" : "MAT:0000272" + }, { + "val" : "MIAA:0000272" + }, { + "val" : "RETIRED_EHDAA2:0000669" + }, { + "val" : "TAO:0001064" + }, { + "val" : "VHOG:0000672" + }, { + "val" : "Wikipedia:Rhombomere" + }, { + "val" : "XAO:0004079" + }, { + "val" : "ZFA:0001064" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001895", + "lbl" : "metencephalon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified].", + "xrefs" : [ "Wikipedia:Metencephalon", "https://github.com/obophenotype/uberon/issues/300" ] + }, + "comments" : [ "the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]." ], + "xrefs" : [ { + "val" : "BAMS:Met" + }, { + "val" : "BIRNLEX:965" + }, { + "val" : "BTO:0000673" + }, { + "val" : "CALOHA:TS-2029" + }, { + "val" : "DHBA:10655" + }, { + "val" : "EHDAA2:0001149" + }, { + "val" : "EHDAA:5498" + }, { + "val" : "EMAPA:17071" + }, { + "val" : "FMA:62003" + }, { + "val" : "GAID:594" + }, { + "val" : "HBA:4833" + }, { + "val" : "MA:0000197" + }, { + "val" : "MESH:D020540" + }, { + "val" : "NCIT:C32741" + }, { + "val" : "VHOG:0000741" + }, { + "val" : "Wikipedia:Metencephalon" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001896", + "lbl" : "medulla oblongata", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO].", + "xrefs" : [ "FMA:62004", "GO:0021550", "Wikipedia:Bone_marrow_of_ovary_oblongata" ] + }, + "xrefs" : [ { + "val" : "AAO:0010486" + }, { + "val" : "BAMS:MY" + }, { + "val" : "BAMS:Md" + }, { + "val" : "BIRNLEX:957" + }, { + "val" : "BM:Me" + }, { + "val" : "BTO:0000041" + }, { + "val" : "CALOHA:TS-0607" + }, { + "val" : "DMBA:17352" + }, { + "val" : "EFO:0000924" + }, { + "val" : "EHDAA2:0001088" + }, { + "val" : "EHDAA:7588" + }, { + "val" : "EMAPA:17550" + }, { + "val" : "EV:0100275" + }, { + "val" : "FMA:62004" + }, { + "val" : "GAID:590" + }, { + "val" : "MA:0000206" + }, { + "val" : "MAT:0000111" + }, { + "val" : "MAT:0000367" + }, { + "val" : "MBA:354" + }, { + "val" : "MESH:D008526" + }, { + "val" : "MIAA:0000111" + }, { + "val" : "NCIT:C12442" + }, { + "val" : "SCTID:279104005" + }, { + "val" : "TAO:0000545" + }, { + "val" : "VHOG:0000181" + }, { + "val" : "Wikipedia:Bone_marrow_of_ovary_oblongata" + }, { + "val" : "XAO:0003100" + }, { + "val" : "ZFA:0000545" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001901", + "lbl" : "epithelium of trachea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial lining of the trachea which contains numerous ciliated cells.", + "xrefs" : [ "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002285" ] + }, + "xrefs" : [ { + "val" : "BTO:0001389" + }, { + "val" : "CALOHA:TS-1061" + }, { + "val" : "EHDAA2:0002069" + }, { + "val" : "EHDAA:5007" + }, { + "val" : "EMAPA:16855" + }, { + "val" : "EMAPA:18409" + }, { + "val" : "FMA:62015" + }, { + "val" : "MA:0001862" + }, { + "val" : "NCIT:C33797" + }, { + "val" : "VHOG:0001045" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001902", + "lbl" : "epithelium of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a small intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001258" + }, { + "val" : "CALOHA:TS-2104" + }, { + "val" : "EMAPA:35778" + }, { + "val" : "FMA:62017" + }, { + "val" : "MA:0001553" + }, { + "val" : "SCTID:45480009" + }, { + "val" : "TAO:0005127" + }, { + "val" : "ZFA:0005127" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001915", + "lbl" : "endothelium of capillary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a capillary [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004954" + }, { + "val" : "CALOHA:TS-0112" + }, { + "val" : "EMAPA:36292" + }, { + "val" : "FMA:62114" + }, { + "val" : "MA:0000711" + }, { + "val" : "NCIT:C49215" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001916", + "lbl" : "endothelium of arteriole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of an arteriole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36286" + }, { + "val" : "FMA:62115" + }, { + "val" : "MA:0000705" + }, { + "val" : "NCIT:C49192" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001917", + "lbl" : "endothelium of artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of an artery [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0011013" + }, { + "val" : "BTO:0004757" + }, { + "val" : "EMAPA:35148" + }, { + "val" : "FMA:62116" + }, { + "val" : "MA:0000707" + }, { + "val" : "NCIT:C49194" + }, { + "val" : "VHOG:0001215" + }, { + "val" : "XAO:0000357" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001918", + "lbl" : "endothelium of venule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a venule [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36290" + }, { + "val" : "FMA:62117" + }, { + "val" : "MA:0000716" + }, { + "val" : "NCIT:C49319" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001919", + "lbl" : "endothelium of vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a vein [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0011110" + }, { + "val" : "BTO:0004756" + }, { + "val" : "EMAPA:36288" + }, { + "val" : "FMA:62118" + }, { + "val" : "MA:0000712" + }, { + "val" : "NCIT:C49317" + }, { + "val" : "VHOG:0001216" + }, { + "val" : "XAO:0000358" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001943", + "lbl" : "midbrain tegmentum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP].", + "xrefs" : [ "FMA:FMA", "ISBN:0471888893", "Wikipedia:Midbrain_tegmentum" ] + }, + "comments" : [ "'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum" ], + "xrefs" : [ { + "val" : "BAMS:MTg" + }, { + "val" : "BIRNLEX:1200" + }, { + "val" : "BTO:0003388" + }, { + "val" : "DHBA:12195" + }, { + "val" : "EFO:0000921" + }, { + "val" : "EHDAA2:0004475" + }, { + "val" : "EMAPA:18215" + }, { + "val" : "FMA:62393" + }, { + "val" : "HBA:9002" + }, { + "val" : "MA:0000212" + }, { + "val" : "MAT:0000452" + }, { + "val" : "SCTID:362392007" + }, { + "val" : "TAO:0000160" + }, { + "val" : "VHOG:0001367" + }, { + "val" : "Wikipedia:Midbrain_tegmentum" + }, { + "val" : "XAO:0004271" + }, { + "val" : "ZFA:0000160" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001948", + "lbl" : "regional part of spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multi-tissue structure that is part of a spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1496" + }, { + "val" : "NCIT:C33969" + }, { + "val" : "SCTID:244437008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001955", + "lbl" : "epithelium of respiratory bronchiole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a respiratory bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35730" + }, { + "val" : "FMA:62498" + }, { + "val" : "MA:0001773" + }, { + "val" : "NCIT:C48943" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001956", + "lbl" : "cartilage of bronchus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP].", + "xrefs" : [ "MP:0010988" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35192" + }, { + "val" : "FMA:62649" + }, { + "val" : "MA:0001835" + }, { + "val" : "NCIT:C49209" + }, { + "val" : "SCTID:278980009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001957", + "lbl" : "submucosa of bronchus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002108" + }, { + "val" : "FMA:62653" + }, { + "val" : "MA:0001837" + }, { + "val" : "NCIT:C49214" + }, { + "val" : "SCTID:85546005" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001958", + "lbl" : "terminal bronchiole epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that lines a terminal bronchiole.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36283" + }, { + "val" : "FMA:62794" + }, { + "val" : "MA:0001774" + }, { + "val" : "NCIT:C33755" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001969", + "lbl" : "blood plasma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The liquid component of blood, in which erythrocytes are suspended.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000131" + }, { + "val" : "CALOHA:TS-0800" + }, { + "val" : "EFO:0001905" + }, { + "val" : "EMAPA:35690" + }, { + "val" : "FMA:62970" + }, { + "val" : "GAID:1178" + }, { + "val" : "MA:0002501" + }, { + "val" : "MAT:0000052" + }, { + "val" : "MESH:D010949" + }, { + "val" : "MIAA:0000052" + }, { + "val" : "NCIT:C13356" + }, { + "val" : "Wikipedia:Blood_plasma" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "lbl" : "bile", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium.", + "xrefs" : [ "DOI:10.1002/cphy.c120027", "Wikipedia:Bile" ] + }, + "xrefs" : [ { + "val" : "BTO:0000121" + }, { + "val" : "CALOHA:TS-1172" + }, { + "val" : "ENVO:02000023" + }, { + "val" : "FMA:62971" + }, { + "val" : "GAID:1157" + }, { + "val" : "MA:0002513" + }, { + "val" : "MESH:D001646" + }, { + "val" : "NCIT:C13192" + }, { + "val" : "Wikipedia:Bile" + }, { + "val" : "ZFA:0005857" + }, { + "val" : "galen:Bile" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001971", + "lbl" : "gastric juice", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0000501" + }, { + "val" : "FMA:62972" + }, { + "val" : "GAID:1160" + }, { + "val" : "MA:0002519" + }, { + "val" : "MESH:D005750" + }, { + "val" : "NCIT:C32661" + }, { + "val" : "Wikipedia:Gastric_juice" + }, { + "val" : "galen:GastricJuice" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001972", + "lbl" : "submucosa of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002109" + }, { + "val" : "EMAPA:35325" + }, { + "val" : "FMA:62997" + }, { + "val" : "MA:0002724" + }, { + "val" : "SCTID:362128009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001974", + "lbl" : "lamina propria of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26987" + }, { + "val" : "FMA:63050" + }, { + "val" : "MA:0001568" + }, { + "val" : "NCIT:C49223" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001975", + "lbl" : "serosa of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35322" + }, { + "val" : "FMA:63057" + }, { + "val" : "MA:0001571" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001976", + "lbl" : "epithelium of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial layer that lines the luminal space of the esophagus.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0000468" ] + }, + "xrefs" : [ { + "val" : "BTO:0001578" + }, { + "val" : "CALOHA:TS-0698" + }, { + "val" : "EFO:0003041" + }, { + "val" : "EHDAA2:0001287" + }, { + "val" : "EMAPA:16835" + }, { + "val" : "FMA:63063" + }, { + "val" : "MA:0001565" + }, { + "val" : "NCIT:C49221" + }, { + "val" : "TAO:0001499" + }, { + "val" : "ZFA:0001499" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001978", + "lbl" : "parenchyma of pancreas", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:32925" + }, { + "val" : "FMA:63120" + }, { + "val" : "MA:0000724" + }, { + "val" : "SCTID:371401008" + }, { + "val" : "VHOG:0001430" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001979", + "lbl" : "venule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins.", + "xrefs" : [ "MESH:A07.231.432.952", "MP:0004125" ] + }, + "xrefs" : [ { + "val" : "BTO:0002626" + }, { + "val" : "EMAPA:35917" + }, { + "val" : "FMA:63130" + }, { + "val" : "MA:0000071" + }, { + "val" : "MESH:D014699" + }, { + "val" : "NCIT:C12818" + }, { + "val" : "SCTID:341687009" + }, { + "val" : "TAO:0005315" + }, { + "val" : "VHOG:0001765" + }, { + "val" : "Wikipedia:Venule" + }, { + "val" : "ZFA:0005315" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001980", + "lbl" : "arteriole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The smallest division of the artery located between the muscular arteries and the capillaries[GO].", + "xrefs" : [ "GO:0014830" ] + }, + "xrefs" : [ { + "val" : "AAO:0010253" + }, { + "val" : "BTO:0001997" + }, { + "val" : "EMAPA:35146" + }, { + "val" : "FMA:63182" + }, { + "val" : "MA:0000063" + }, { + "val" : "MESH:D001160" + }, { + "val" : "NCIT:C12672" + }, { + "val" : "SCTID:337724002" + }, { + "val" : "TAO:0002138" + }, { + "val" : "VHOG:0001763" + }, { + "val" : "Wikipedia:Arteriole" + }, { + "val" : "ZFA:0005255" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001981", + "lbl" : "blood vessel", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vessel through which blood circulates in the body.", + "xrefs" : [ "BTO:0001102", "Wikipedia:Blood_vessel" ] + }, + "xrefs" : [ { + "val" : "AAO:0011004" + }, { + "val" : "AEO:0000207" + }, { + "val" : "BTO:0001102" + }, { + "val" : "CALOHA:TS-0080" + }, { + "val" : "EFO:0000817" + }, { + "val" : "EHDAA2:0003252" + }, { + "val" : "EHDAA:240" + }, { + "val" : "EMAPA:32743" + }, { + "val" : "EMAPA:35993" + }, { + "val" : "FMA:50722" + }, { + "val" : "FMA:63183" + }, { + "val" : "GAID:169" + }, { + "val" : "MA:0000060" + }, { + "val" : "MAT:0000393" + }, { + "val" : "MESH:D001808" + }, { + "val" : "NCIT:C12679" + }, { + "val" : "NLXANAT:090901" + }, { + "val" : "SCTID:361097006" + }, { + "val" : "TAO:0002137" + }, { + "val" : "VHOG:0001250" + }, { + "val" : "Wikipedia:Blood_vessel" + }, { + "val" : "XAO:0001011" + }, { + "val" : "ZFA:0005314" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001982", + "lbl" : "capillary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the smallest blood vessels connecting arterioles with venules.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Capillary", "https://github.com/obophenotype/uberon/issues/137" ] + }, + "xrefs" : [ { + "val" : "AAO:0010252" + }, { + "val" : "BTO:0002045" + }, { + "val" : "CALOHA:TS-2006" + }, { + "val" : "EFO:0001906" + }, { + "val" : "EMAPA:35198" + }, { + "val" : "EV:0100035" + }, { + "val" : "FMA:63194" + }, { + "val" : "MA:0000065" + }, { + "val" : "MESH:D002196" + }, { + "val" : "NCIT:C12685" + }, { + "val" : "NLXANAT:090902" + }, { + "val" : "TAO:0005250" + }, { + "val" : "VHOG:0001253" + }, { + "val" : "Wikipedia:Capillary" + }, { + "val" : "XAO:0000116" + }, { + "val" : "ZFA:0005250" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001985", + "lbl" : "corneal endothelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP].", + "xrefs" : [ "Wikipedia:Corneal_endothelium" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0172" + }, { + "val" : "EMAPA:35935" + }, { + "val" : "FMA:63882" + }, { + "val" : "GAID:891" + }, { + "val" : "MA:0001242" + }, { + "val" : "MESH:D004728" + }, { + "val" : "NCIT:C12707" + }, { + "val" : "SCTID:368827009" + }, { + "val" : "TAO:0002186" + }, { + "val" : "Wikipedia:Corneal_endothelium" + }, { + "val" : "ZFA:0001687" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001986", + "lbl" : "endothelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA].", + "xrefs" : [ "FMA:63916", "MESH:A10.272.491", "https://github.com/obophenotype/uberon/issues/225" ] + }, + "comments" : [ "The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980)" ], + "xrefs" : [ { + "val" : "BTO:0000393" + }, { + "val" : "CALOHA:TS-0278" + }, { + "val" : "EFO:0002548" + }, { + "val" : "FMA:63916" + }, { + "val" : "GAID:520" + }, { + "val" : "MESH:D004727" + }, { + "val" : "NCIT:C12481" + }, { + "val" : "SCTID:27168002" + }, { + "val" : "galen:Endothelium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001988", + "lbl" : "feces", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of semisolid bodily waste discharged through the anus[MW,modified].", + "xrefs" : [ "Wikipedia:Feces", "http://www.merriam-webster.com/dictionary/feces" ] + }, + "xrefs" : [ { + "val" : "BTO:0000440" + }, { + "val" : "CALOHA:TS-2345" + }, { + "val" : "ENVO:00002003" + }, { + "val" : "FMA:64183" + }, { + "val" : "GAID:1199" + }, { + "val" : "MA:0002509" + }, { + "val" : "MAT:0000053" + }, { + "val" : "MESH:D005243" + }, { + "val" : "MIAA:0000053" + }, { + "val" : "NCIT:C13234" + }, { + "val" : "Wikipedia:Feces" + }, { + "val" : "galen:Feces" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001994", + "lbl" : "hyaline cartilage tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000094", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35414" + }, { + "val" : "FMA:64783" + }, { + "val" : "MA:0000109" + }, { + "val" : "NCIT:C32746" + }, { + "val" : "SCTID:39298000" + }, { + "val" : "VSAO:0000094" + }, { + "val" : "Wikipedia:Hyaline_cartilage" + }, { + "val" : "XAO:0004029" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002012", + "lbl" : "pulmonary artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood..", + "xrefs" : [ "Wikipedia:Pulmonary_artery", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010221" + }, { + "val" : "BTO:0000778" + }, { + "val" : "CALOHA:TS-0839" + }, { + "val" : "EFO:0001399" + }, { + "val" : "EHDAA2:0001575" + }, { + "val" : "EHDAA:4351" + }, { + "val" : "EMAPA:17008" + }, { + "val" : "FMA:66326" + }, { + "val" : "GAID:505" + }, { + "val" : "MA:0002031" + }, { + "val" : "MESH:D011651" + }, { + "val" : "NCIT:C12774" + }, { + "val" : "SCTID:181380003" + }, { + "val" : "VHOG:0000982" + }, { + "val" : "Wikipedia:Pulmonary_artery" + }, { + "val" : "XAO:0004162" + }, { + "val" : "galen:PulmonaryArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002016", + "lbl" : "pulmonary vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO].", + "xrefs" : [ "GO:0060577" ] + }, + "xrefs" : [ { + "val" : "AAO:0010521" + }, { + "val" : "BTO:0001799" + }, { + "val" : "CALOHA:TS-0840" + }, { + "val" : "EHDAA2:0001579" + }, { + "val" : "EHDAA:2629" + }, { + "val" : "EMAPA:18645" + }, { + "val" : "FMA:66643" + }, { + "val" : "GAID:543" + }, { + "val" : "MA:0002206" + }, { + "val" : "MESH:D011667" + }, { + "val" : "NCIT:C12776" + }, { + "val" : "SCTID:430160002" + }, { + "val" : "VHOG:0001133" + }, { + "val" : "Wikipedia:Pulmonary_vein" + }, { + "val" : "XAO:0000394" + }, { + "val" : "galen:PulmonaryVein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002017", + "lbl" : "portal vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO].", + "xrefs" : [ "BTO:0001792" ] + }, + "xrefs" : [ { + "val" : "BTO:0001792" + }, { + "val" : "CALOHA:TS-0814" + }, { + "val" : "EHDAA2:0001485" + }, { + "val" : "EHDAA:6510" + }, { + "val" : "EMAPA:17349" + }, { + "val" : "FMA:66645" + }, { + "val" : "GAID:540" + }, { + "val" : "MA:0002198" + }, { + "val" : "MESH:D011169" + }, { + "val" : "NCIT:C33343" + }, { + "val" : "SCTID:362064007" + }, { + "val" : "VHOG:0000656" + }, { + "val" : "XAO:0000392" + }, { + "val" : "galen:PortalVein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002020", + "lbl" : "gray matter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons.", + "xrefs" : [ "Wikipedia:Gray_matter", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0001012" + }, { + "val" : "EHDAA2:0003136" + }, { + "val" : "EHDAA2_RETIRED:0004658" + }, { + "val" : "FMA:67242" + }, { + "val" : "HBA:4006" + }, { + "val" : "MA:0001112" + }, { + "val" : "NCIT:C32695" + }, { + "val" : "TAO:0002197" + }, { + "val" : "VHOG:0001768" + }, { + "val" : "Wikipedia:Gray_matter" + }, { + "val" : "ZFA:0001681" + }, { + "val" : "neuronames:2869" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002028", + "lbl" : "hindbrain", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA].", + "xrefs" : [ "Wikipedia:Rhombencephalon", "ZFA:0000029", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0010150" + }, { + "val" : "BAMS:HB" + }, { + "val" : "BIRNLEX:942" + }, { + "val" : "BTO:0000672" + }, { + "val" : "CALOHA:TS-0457" + }, { + "val" : "DHBA:10653" + }, { + "val" : "DMBA:16808" + }, { + "val" : "EFO:0000923" + }, { + "val" : "EHDAA2:0000746" + }, { + "val" : "EHDAA:3514" + }, { + "val" : "EHDAA:6487" + }, { + "val" : "EMAPA:16916" + }, { + "val" : "FMA:67687" + }, { + "val" : "MA:0000195" + }, { + "val" : "MAT:0000107" + }, { + "val" : "MBA:1065" + }, { + "val" : "MESH:D012249" + }, { + "val" : "MIAA:0000107" + }, { + "val" : "NCIT:C40336" + }, { + "val" : "SCTID:303456008" + }, { + "val" : "TAO:0000029" + }, { + "val" : "VHOG:0000070" + }, { + "val" : "Wikipedia:Rhombencephalon" + }, { + "val" : "XAO:0000015" + }, { + "val" : "ZFA:0000029" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "lbl" : "epithelium of gall bladder", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The simple columnar epithelial lining of the gall bladder.", + "xrefs" : [ "MP:0009492" ] + }, + "xrefs" : [ { + "val" : "BTO:0001449" + }, { + "val" : "CALOHA:TS-1304" + }, { + "val" : "EMAPA:35370" + }, { + "val" : "FMA:67711" + }, { + "val" : "MA:0001632" + }, { + "val" : "NCIT:C49227" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002031", + "lbl" : "epithelium of bronchus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001845" + }, { + "val" : "CALOHA:TS-1240" + }, { + "val" : "EFO:0000307" + }, { + "val" : "EMAPA:32691" + }, { + "val" : "FMA:67782" + }, { + "val" : "MA:0001839" + }, { + "val" : "NCIT:C32231" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002036", + "lbl" : "striated muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle tissue that contains fibers that are divided by transverse bands into striations.", + "xrefs" : [ "CL:0000737", "GOC:dph", "GOC:mtg_muscle" ] + }, + "xrefs" : [ { + "val" : "AAO:0010762" + }, { + "val" : "AEO:0000140" + }, { + "val" : "CALOHA:TS-2047" + }, { + "val" : "EHDAA2:0003140" + }, { + "val" : "EMAPA:36390" + }, { + "val" : "FMA:67905" + }, { + "val" : "MA:0002438" + }, { + "val" : "NCIT:C12436" + }, { + "val" : "WBbt:0005779" + }, { + "val" : "Wikipedia:Striated_muscle" + }, { + "val" : "galen:StriatedMuscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002040", + "lbl" : "bronchial artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A systemic artery that supplies the lung with with oxygenated blood.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Bronchial_artery" ] + }, + "comments" : [ "Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung." ], + "xrefs" : [ { + "val" : "EMAPA:18608" + }, { + "val" : "FMA:68109" + }, { + "val" : "GAID:477" + }, { + "val" : "MA:0001923" + }, { + "val" : "MESH:D001981" + }, { + "val" : "NCIT:C32230" + }, { + "val" : "SCTID:244247009" + }, { + "val" : "Wikipedia:Bronchial_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002047", + "lbl" : "pontine raphe nucleus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Pontine_raphe_nucleus" ] + }, + "xrefs" : [ { + "val" : "BAMS:PnR" + }, { + "val" : "BAMS:RA-PONS" + }, { + "val" : "BAMS:RPn" + }, { + "val" : "BIRNLEX:1110" + }, { + "val" : "DHBA:12471" + }, { + "val" : "DHBA:12475" + }, { + "val" : "FMA:68875" + }, { + "val" : "HBA:9159" + }, { + "val" : "MA:0001022" + }, { + "val" : "MBA:238" + }, { + "val" : "Wikipedia:Pontine_raphe_nucleus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002048", + "lbl" : "lung", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Respiration organ that develops as an outpocketing of the esophagus.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP]" ], + "xrefs" : [ { + "val" : "AAO:0000275" + }, { + "val" : "AAO:0010567" + }, { + "val" : "BTO:0000763" + }, { + "val" : "CALOHA:TS-0568" + }, { + "val" : "EFO:0000934" + }, { + "val" : "EHDAA2:0001042" + }, { + "val" : "EHDAA:1554" + }, { + "val" : "EHDAA:2205" + }, { + "val" : "EMAPA:16728" + }, { + "val" : "EV:0100042" + }, { + "val" : "FMA:7195" + }, { + "val" : "GAID:345" + }, { + "val" : "MA:0000415" + }, { + "val" : "MAT:0000135" + }, { + "val" : "MESH:D008168" + }, { + "val" : "MIAA:0000135" + }, { + "val" : "NCIT:C12468" + }, { + "val" : "SCTID:181216001" + }, { + "val" : "Wikipedia:Lung" + }, { + "val" : "XAO:0000119" + }, { + "val" : "galen:Lung" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002049", + "lbl" : "vasculature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face.", + "xrefs" : [ "ZFA:0005249" ] + }, + "xrefs" : [ { + "val" : "BTO:0003718" + }, { + "val" : "FMA:69050" + }, { + "val" : "TAO:0005249" + }, { + "val" : "ZFA:0005249" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002050", + "lbl" : "embryonic structure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that is part of an embryo.", + "xrefs" : [ "BTO:0000174", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0000138" + }, { + "val" : "BILA:0000034" + }, { + "val" : "BTO:0000174" + }, { + "val" : "CALOHA:TS-2110" + }, { + "val" : "EFO:0000461" + }, { + "val" : "FMA:69067" + }, { + "val" : "GAID:407" + }, { + "val" : "MESH:D004628" + }, { + "val" : "NCIT:C13229" + }, { + "val" : "RETIRED_EHDAA2:0003169" + }, { + "val" : "SCTID:667009" + }, { + "val" : "TAO:0001105" + }, { + "val" : "VSAO:0000178" + }, { + "val" : "XAO:0003042" + }, { + "val" : "ZFA:0001105" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002051", + "lbl" : "epithelium of bronchiole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001866" + }, { + "val" : "CALOHA:TS-0570" + }, { + "val" : "EMAPA:32693" + }, { + "val" : "FMA:69077" + }, { + "val" : "MA:0001772" + }, { + "val" : "NCIT:C48942" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002057", + "lbl" : "phrenic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that supplies the diaphragm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:69330" + }, { + "val" : "MA:0002019" + }, { + "val" : "NCIT:C33320" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002061", + "lbl" : "truncus arteriosus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles.", + "xrefs" : [ "Wikipedia:Truncus_arteriosus_(embryology)" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004143" + }, { + "val" : "EMAPA:35887" + }, { + "val" : "FMA:70301" + }, { + "val" : "GAID:554" + }, { + "val" : "MA:0000103" + }, { + "val" : "MESH:D014338" + }, { + "val" : "NCIT:C34317" + }, { + "val" : "SCTID:308828009" + }, { + "val" : "Wikipedia:Truncus_arteriosus_(embryology)" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002062", + "lbl" : "endocardial cushion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA].", + "xrefs" : [ "GO:0003197", "Wikipedia:Atrioventricular_cushions", "ZFIN:curator" ] + }, + "comments" : [ "GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form" ], + "xrefs" : [ { + "val" : "EHDAA2:0000434" + }, { + "val" : "EHDAA2:0004028" + }, { + "val" : "EHDAA:2586" + }, { + "val" : "EMAPA:16696" + }, { + "val" : "FMA:70302" + }, { + "val" : "MA:0000078" + }, { + "val" : "TAO:0001317" + }, { + "val" : "VHOG:0000932" + }, { + "val" : "Wikipedia:Atrioventricular_cushions" + }, { + "val" : "XAO:0004189" + }, { + "val" : "ZFA:0001317" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002063", + "lbl" : "sinus venosus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart.", + "xrefs" : [ "PMID:20735616", "Wikipedia:Sinus_venosus" ] + }, + "xrefs" : [ { + "val" : "AAO:0010505" + }, { + "val" : "EHDAA2:0001839" + }, { + "val" : "EHDAA:480" + }, { + "val" : "EMAPA:16237" + }, { + "val" : "FMA:70303" + }, { + "val" : "NCIT:C34299" + }, { + "val" : "NCIT:C34300" + }, { + "val" : "TAO:0000154" + }, { + "val" : "VHOG:0000177" + }, { + "val" : "Wikipedia:Sinus_venosus" + }, { + "val" : "ZFA:0000154" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002067", + "lbl" : "dermis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP].", + "xrefs" : [ "Wikipedia:Dermis", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0000128" + }, { + "val" : "BTO:0000294" + }, { + "val" : "CALOHA:TS-2076" + }, { + "val" : "EFO:0000953" + }, { + "val" : "EMAPA:17527" + }, { + "val" : "EV:0100154" + }, { + "val" : "FMA:70323" + }, { + "val" : "GAID:1321" + }, { + "val" : "MA:0000152" + }, { + "val" : "MAT:0000153" + }, { + "val" : "MESH:D020405" + }, { + "val" : "MIAA:0000153" + }, { + "val" : "NCIT:C12701" + }, { + "val" : "SCTID:361696001" + }, { + "val" : "TAO:0001119" + }, { + "val" : "VHOG:0000108" + }, { + "val" : "Wikipedia:Dermis" + }, { + "val" : "XAO:0000217" + }, { + "val" : "ZFA:0001119" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002072", + "lbl" : "hypodermis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP].", + "xrefs" : [ "Wikipedia:Hypodermis" ] + }, + "xrefs" : [ { + "val" : "BTO:0001314" + }, { + "val" : "CALOHA:TS-2366" + }, { + "val" : "FMA:70544" + }, { + "val" : "NCIT:C33645" + }, { + "val" : "TAO:0001136" + }, { + "val" : "Wikipedia:Hypodermis" + }, { + "val" : "ZFA:0001136" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002075", + "lbl" : "viscus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen.", + "xrefs" : [ "BTO:0001491", "Wikipedia:Viscus", "https://github.com/obophenotype/mouse-anatomy-ontology/issues/14" ] + }, + "xrefs" : [ { + "val" : "AAO:0010386" + }, { + "val" : "BTO:0001491" + }, { + "val" : "EHDAA:512" + }, { + "val" : "EMAPA:16245" + }, { + "val" : "FMA:7085" + }, { + "val" : "MA:0000019" + }, { + "val" : "MESH:D014781" + }, { + "val" : "NCIT:C28287" + }, { + "val" : "RETIRED_EHDAA2:0002201" + }, { + "val" : "SCTID:118760003" + }, { + "val" : "Wikipedia:Viscus" + }, { + "val" : "XAO:0003034" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002078", + "lbl" : "right cardiac atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve.", + "xrefs" : [ "Wikipedia:Right_atrium", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010248" + }, { + "val" : "BTO:0001703" + }, { + "val" : "EHDAA2:0000290" + }, { + "val" : "EMAPA:17321" + }, { + "val" : "FMA:7096" + }, { + "val" : "MA:0000075" + }, { + "val" : "NCIT:C12868" + }, { + "val" : "SCTID:244383003" + }, { + "val" : "VHOG:0000328" + }, { + "val" : "Wikipedia:Right_atrium" + }, { + "val" : "XAO:0003192" + }, { + "val" : "galen:RightAtrium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002079", + "lbl" : "left cardiac atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve.", + "xrefs" : [ "Wikipedia:Left_atrium", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010247" + }, { + "val" : "BTO:0001702" + }, { + "val" : "EHDAA2:0000275" + }, { + "val" : "EMAPA:17315" + }, { + "val" : "FMA:7097" + }, { + "val" : "MA:0000074" + }, { + "val" : "NCIT:C12869" + }, { + "val" : "SCTID:244387002" + }, { + "val" : "VHOG:0000369" + }, { + "val" : "Wikipedia:Left_atrium" + }, { + "val" : "XAO:0003191" + }, { + "val" : "galen:LeftAtrium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002080", + "lbl" : "heart right ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac ventricle that is in the right side of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001630" + }, { + "val" : "CALOHA:TS-0443" + }, { + "val" : "EHDAA2:0000196" + }, { + "val" : "EMAPA:17340" + }, { + "val" : "FMA:7098" + }, { + "val" : "MA:0000093" + }, { + "val" : "NCIT:C12870" + }, { + "val" : "SCTID:244384009" + }, { + "val" : "VHOG:0000717" + }, { + "val" : "Wikipedia:Right_ventricle" + }, { + "val" : "galen:RightVentricle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002081", + "lbl" : "cardiac atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cardiac chamber in which blood enters the heart.", + "xrefs" : [ "Wikipedia:Heart_atrium", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010246" + }, { + "val" : "BTO:0000903" + }, { + "val" : "CALOHA:TS-0437" + }, { + "val" : "EFO:0000277" + }, { + "val" : "EHDAA2:0000154" + }, { + "val" : "EHDAA:1265" + }, { + "val" : "EMAPA:16688" + }, { + "val" : "EV:0100019" + }, { + "val" : "FMA:7099" + }, { + "val" : "GAID:555" + }, { + "val" : "MA:0000073" + }, { + "val" : "MAT:0000496" + }, { + "val" : "MESH:D006325" + }, { + "val" : "NCIT:C12728" + }, { + "val" : "SCTID:261405004" + }, { + "val" : "TAO:0000471" + }, { + "val" : "VHOG:0000175" + }, { + "val" : "Wikipedia:Heart_atrium" + }, { + "val" : "ZFA:0000471" + }, { + "val" : "galen:Atrium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002082", + "lbl" : "cardiac ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cardiac chamber through which blood leaves the heart.", + "xrefs" : [ "Wikipedia:Ventricle_(heart)", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010249" + }, { + "val" : "BTO:0000862" + }, { + "val" : "CALOHA:TS-0444" + }, { + "val" : "EFO:0000317" + }, { + "val" : "EHDAA2:0004164" + }, { + "val" : "EHDAA:1912" + }, { + "val" : "EMAPA:17331" + }, { + "val" : "EV:0100020" + }, { + "val" : "FMA:7100" + }, { + "val" : "GAID:568" + }, { + "val" : "MA:0000091" + }, { + "val" : "MAT:0000497" + }, { + "val" : "MESH:D006352" + }, { + "val" : "NCIT:C12730" + }, { + "val" : "SCTID:277699000" + }, { + "val" : "TAO:0000009" + }, { + "val" : "VHOG:0000435" + }, { + "val" : "Wikipedia:Ventricle_(heart)" + }, { + "val" : "XAO:0003193" + }, { + "val" : "ZFA:0000009" + }, { + "val" : "galen:Ventricle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002084", + "lbl" : "heart left ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac ventricle that is in the left side of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001629" + }, { + "val" : "CALOHA:TS-0439" + }, { + "val" : "EHDAA2:0002178" + }, { + "val" : "EMAPA:17337" + }, { + "val" : "FMA:7101" + }, { + "val" : "MA:0000092" + }, { + "val" : "NCIT:C12871" + }, { + "val" : "SCTID:244385005" + }, { + "val" : "VHOG:0000718" + }, { + "val" : "Wikipedia:Left_ventricle" + }, { + "val" : "galen:LeftVentricle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002085", + "lbl" : "interatrial septum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac septum that divides the left and right atria of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000838" + }, { + "val" : "EHDAA:1896" + }, { + "val" : "EMAPA:17011" + }, { + "val" : "FMA:7108" + }, { + "val" : "MA:0000084" + }, { + "val" : "NCIT:C32818" + }, { + "val" : "SCTID:362016003" + }, { + "val" : "VHOG:0000385" + }, { + "val" : "Wikipedia:Interatrial_septum" + }, { + "val" : "galen:InteratrialSeptum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002090", + "lbl" : "postcranial axial skeleton", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA].", + "xrefs" : [ "ZFA:0000317", "https://sourceforge.net/tracker/?func=detail&aid=2983975&group_id=76834&atid=974957", "https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=2983977&group_id=76834" ] + }, + "comments" : [ "previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed." ], + "xrefs" : [ { + "val" : "AAO:0000034" + }, { + "val" : "EFO:0000942" + }, { + "val" : "EHDAA2:0000161" + }, { + "val" : "EHDAA:5049" + }, { + "val" : "FMA:71221" + }, { + "val" : "MA:0002986" + }, { + "val" : "MAT:0000148" + }, { + "val" : "MIAA:0000148" + }, { + "val" : "TAO:0000317" + }, { + "val" : "VHOG:0000317" + }, { + "val" : "VSAO:0000093" + }, { + "val" : "XAO:0003073" + }, { + "val" : "ZFA:0000317" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002091", + "lbl" : "appendicular skeleton", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm].", + "xrefs" : [ "UBERONREF:0000003", "Wikipedia:Appendicular_skeleton", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000747" + }, { + "val" : "EFO:0000951" + }, { + "val" : "EMAPA:32729" + }, { + "val" : "FMA:71222" + }, { + "val" : "MA:0000290" + }, { + "val" : "MAT:0000278" + }, { + "val" : "MIAA:0000278" + }, { + "val" : "NCIT:C49477" + }, { + "val" : "SCTID:322050006" + }, { + "val" : "VSAO:0000076" + }, { + "val" : "Wikipedia:Appendicular_skeleton" + }, { + "val" : "XAO:0003166" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002094", + "lbl" : "interventricular septum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cardiac septum which separates the right ventricle from the left ventricle.[FMA].", + "xrefs" : [ "FMA:7133" ] + }, + "xrefs" : [ { + "val" : "BTO:0002483" + }, { + "val" : "EFO:0001956" + }, { + "val" : "EHDAA:2603" + }, { + "val" : "EMAPA:17333" + }, { + "val" : "FMA:7133" + }, { + "val" : "MA:0000085" + }, { + "val" : "NCIT:C32874" + }, { + "val" : "SCTID:362019005" + }, { + "val" : "VHOG:0000386" + }, { + "val" : "Wikipedia:Interventricular_septum" + }, { + "val" : "galen:InterventricularSeptum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002095", + "lbl" : "mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon.", + "xrefs" : [ "FMA:7144", "Wikipedia:Mesentery", "Wikipedia:Mesentery#Mesentery_.28general.29", "https://github.com/obophenotype/uberon/issues/85" ] + }, + "xrefs" : [ { + "val" : "AAO:0011061" + }, { + "val" : "BTO:0001380" + }, { + "val" : "EV:0100083" + }, { + "val" : "FMA:7144" + }, { + "val" : "GAID:21" + }, { + "val" : "MESH:D008643" + }, { + "val" : "NCIT:C33103" + }, { + "val" : "SCTID:362707009" + }, { + "val" : "Wikipedia:Mesentery#Mesentery_.28general.29" + }, { + "val" : "galen:Mesentery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002097", + "lbl" : "skin of body", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The organ covering the body that consists of the dermis and epidermis.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "BTO:0001253" + }, { + "val" : "CALOHA:TS-0934" + }, { + "val" : "EFO:0000962" + }, { + "val" : "EHDAA2:0001844" + }, { + "val" : "EMAPA:17525" + }, { + "val" : "FMA:7163" + }, { + "val" : "MESH:D012867" + }, { + "val" : "MFMO:0000099" + }, { + "val" : "NCIT:C12470" + }, { + "val" : "SCTID:181469002" + }, { + "val" : "Wikipedia:Skin" + }, { + "val" : "XAO:0000023" + }, { + "val" : "galen:Skin" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002099", + "lbl" : "cardiac septum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles.", + "xrefs" : [ "MESH:A07.541.459" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35400" + }, { + "val" : "FMA:7180" + }, { + "val" : "GAID:562" + }, { + "val" : "MA:0000083" + }, { + "val" : "MESH:D006346" + }, { + "val" : "NCIT:C49485" + }, { + "val" : "SCTID:362014000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002100", + "lbl" : "trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.", + "xrefs" : [ "TAO:0001115", "UBERONREF:0000006", "Wikipedia:Torso" ] + }, + "xrefs" : [ { + "val" : "AAO:0010339" + }, { + "val" : "BILA:0000116" + }, { + "val" : "BTO:0001493" + }, { + "val" : "CALOHA:TS-1071" + }, { + "val" : "EFO:0000966" + }, { + "val" : "EMAPA:31857" + }, { + "val" : "FMA:7181" + }, { + "val" : "MA:0000004" + }, { + "val" : "MAT:0000296" + }, { + "val" : "MIAA:0000296" + }, { + "val" : "NCIT:C33816" + }, { + "val" : "SCTID:262225004" + }, { + "val" : "TAO:0001115" + }, { + "val" : "Wikipedia:Torso" + }, { + "val" : "XAO:0000054" + }, { + "val" : "XAO:0003025" + }, { + "val" : "ZFA:0001115" + }, { + "val" : "galen:Trunk" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002104", + "lbl" : "visual system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sensory system subserving the sense of vision.", + "xrefs" : [ "NIFSTD:FMAID_7191" ] + }, + "xrefs" : [ { + "val" : "AAO:0000632" + }, { + "val" : "BILA:0000140" + }, { + "val" : "EMAPA:36003" + }, { + "val" : "FMA:7191" + }, { + "val" : "MA:0002444" + }, { + "val" : "NCIT:C12888" + }, { + "val" : "SCTID:281831001" + }, { + "val" : "TAO:0001127" + }, { + "val" : "Wikipedia:Visual_system" + }, { + "val" : "XAO:0003198" + }, { + "val" : "ZFA:0001127" + }, { + "val" : "http://uri.neuinfo.org/nif/nifstd/FMAID_7191" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002105", + "lbl" : "vestibulo-auditory system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Sensory system responsible for the perception of spatial orientation and auditory stimuli.", + "xrefs" : [ "ZFA:0001138" ] + }, + "xrefs" : [ { + "val" : "AAO:0000631" + }, { + "val" : "FMA:78500" + }, { + "val" : "TAO:0001138" + }, { + "val" : "XAO:0003195" + }, { + "val" : "ZFA:0001138" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "lbl" : "spleen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The organ that functions to filter blood and to store red corpuscles and platelets.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0000689" ] + }, + "xrefs" : [ { + "val" : "AAO:0010395" + }, { + "val" : "BTO:0001281" + }, { + "val" : "CALOHA:TS-0956" + }, { + "val" : "EFO:0000869" + }, { + "val" : "EMAPA:18767" + }, { + "val" : "EV:0100055" + }, { + "val" : "FMA:7196" + }, { + "val" : "GAID:1289" + }, { + "val" : "MA:0000141" + }, { + "val" : "MAT:0000085" + }, { + "val" : "MESH:D013154" + }, { + "val" : "MIAA:0000085" + }, { + "val" : "NCIT:C12432" + }, { + "val" : "SCTID:181279003" + }, { + "val" : "TAO:0000436" + }, { + "val" : "VHOG:0000120" + }, { + "val" : "Wikipedia:Spleen" + }, { + "val" : "XAO:0000328" + }, { + "val" : "ZFA:0000436" + }, { + "val" : "galen:Spleen" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "lbl" : "liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].", + "xrefs" : [ "BTO:0000759", "Wikipedia:Liver" ] + }, + "xrefs" : [ { + "val" : "AAO:0010111" + }, { + "val" : "BTO:0000759" + }, { + "val" : "CALOHA:TS-0564" + }, { + "val" : "EFO:0000887" + }, { + "val" : "EHDAA2:0000997" + }, { + "val" : "EHDAA:2197" + }, { + "val" : "EMAPA:16846" + }, { + "val" : "EV:0100089" + }, { + "val" : "FMA:7197" + }, { + "val" : "GAID:288" + }, { + "val" : "MA:0000358" + }, { + "val" : "MAT:0000097" + }, { + "val" : "MESH:D008099" + }, { + "val" : "MIAA:0000097" + }, { + "val" : "NCIT:C12392" + }, { + "val" : "SCTID:181268008" + }, { + "val" : "TAO:0000123" + }, { + "val" : "VHOG:0000257" + }, { + "val" : "Wikipedia:Liver" + }, { + "val" : "XAO:0000133" + }, { + "val" : "ZFA:0000123" + }, { + "val" : "galen:Liver" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "lbl" : "small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong].", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Small_intestine" ] + }, + "xrefs" : [ { + "val" : "AAO:0010397" + }, { + "val" : "BTO:0000651" + }, { + "val" : "CALOHA:TS-0942" + }, { + "val" : "EFO:0000841" + }, { + "val" : "EMAPA:32834" + }, { + "val" : "EV:0100072" + }, { + "val" : "FMA:7200" + }, { + "val" : "GAID:313" + }, { + "val" : "MA:0000337" + }, { + "val" : "MAT:0000047" + }, { + "val" : "MESH:D007421" + }, { + "val" : "MIAA:0000047" + }, { + "val" : "NCIT:C12386" + }, { + "val" : "SCTID:181250005" + }, { + "val" : "TAO:0001323" + }, { + "val" : "VHOG:0000055" + }, { + "val" : "Wikipedia:Small_intestine" + }, { + "val" : "XAO:0000130" + }, { + "val" : "ZFA:0001323" + }, { + "val" : "galen:SmallIntestine" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "lbl" : "gallbladder", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that aids digestion and stores bile produced by the liver[WP].", + "xrefs" : [ "Wikipedia:Gallbladder" ] + }, + "comments" : [ "Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988)" ], + "xrefs" : [ { + "val" : "AAO:0010114" + }, { + "val" : "BTO:0000493" + }, { + "val" : "CALOHA:TS-0394" + }, { + "val" : "EFO:0000853" + }, { + "val" : "EHDAA2:0000699" + }, { + "val" : "EHDAA:8062" + }, { + "val" : "EMAPA:17202" + }, { + "val" : "EV:0100090" + }, { + "val" : "FMA:7202" + }, { + "val" : "MA:0000356" + }, { + "val" : "MAT:0000072" + }, { + "val" : "MESH:D005704" + }, { + "val" : "MIAA:0000072" + }, { + "val" : "NCIT:C12377" + }, { + "val" : "SCTID:181269000" + }, { + "val" : "TAO:0000208" + }, { + "val" : "VHOG:0000221" + }, { + "val" : "Wikipedia:Gallbladder" + }, { + "val" : "XAO:0000135" + }, { + "val" : "ZFA:0000208" + }, { + "val" : "galen:Gallbladder" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002111", + "lbl" : "artery smooth muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of an artery [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000087" + }, { + "val" : "CALOHA:TS-1198" + }, { + "val" : "EMAPA:36285" + }, { + "val" : "FMA:72024" + }, { + "val" : "MA:0000708" + }, { + "val" : "NCIT:C49195" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002112", + "lbl" : "smooth muscle of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35323" + }, { + "val" : "FMA:72025" + }, { + "val" : "MA:0001573" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "lbl" : "duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one).", + "xrefs" : [ "ISBN:0815318960", "Wikipedia:Duodenum" ] + }, + "xrefs" : [ { + "val" : "AAO:0010402" + }, { + "val" : "BTO:0000365" + }, { + "val" : "CALOHA:TS-0214" + }, { + "val" : "EFO:0000851" + }, { + "val" : "EMAPA:18852" + }, { + "val" : "EV:0100073" + }, { + "val" : "FMA:7206" + }, { + "val" : "GAID:284" + }, { + "val" : "MA:0000338" + }, { + "val" : "MAT:0000044" + }, { + "val" : "MESH:D004386" + }, { + "val" : "MIAA:0000044" + }, { + "val" : "NCIT:C12263" + }, { + "val" : "SCTID:181247007" + }, { + "val" : "VHOG:0000052" + }, { + "val" : "Wikipedia:Duodenum" + }, { + "val" : "XAO:0000236" + }, { + "val" : "galen:Duodenum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002118", + "lbl" : "right ovary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ovary that is part of a right side of organism [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7213" + }, { + "val" : "MA:0001705" + }, { + "val" : "NCIT:C33487" + }, { + "val" : "SCTID:280123002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002119", + "lbl" : "left ovary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ovary that is part of a left side of organism [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7214" + }, { + "val" : "MA:0001704" + }, { + "val" : "NCIT:C32969" + }, { + "val" : "SCTID:280124008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002128", + "lbl" : "superior olivary complex", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system.", + "xrefs" : [ "ISBN:0-19-502694-2", "Wikipedia:Superior_olivary_complex" ] + }, + "xrefs" : [ { + "val" : "BAMS:SOC" + }, { + "val" : "BIRNLEX:1307" + }, { + "val" : "DHBA:12462" + }, { + "val" : "EMAPA:35840" + }, { + "val" : "EV:0100263" + }, { + "val" : "FMA:72247" + }, { + "val" : "HBA:9177" + }, { + "val" : "MA:0001026" + }, { + "val" : "MBA:398" + }, { + "val" : "VHOG:0001381" + }, { + "val" : "Wikipedia:Superior_olivary_complex" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002148", + "lbl" : "locus ceruleus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID].", + "xrefs" : [ "GAID:577", "GO:0021703", "Wikipedia:Locus_ceruleus" ] + }, + "xrefs" : [ { + "val" : "BAMS:CAE" + }, { + "val" : "BAMS:LC" + }, { + "val" : "BIRNLEX:905" + }, { + "val" : "BM:Pons-LC" + }, { + "val" : "BTO:0001408" + }, { + "val" : "DHBA:12819" + }, { + "val" : "DMBA:16972" + }, { + "val" : "EFO:0001963" + }, { + "val" : "EMAPA:35502" + }, { + "val" : "FMA:72478" + }, { + "val" : "GAID:577" + }, { + "val" : "HBA:9148" + }, { + "val" : "MA:0001017" + }, { + "val" : "MBA:147" + }, { + "val" : "MESH:D008125" + }, { + "val" : "NCIT:C97333" + }, { + "val" : "SCTID:369016004" + }, { + "val" : "TAO:0000539" + }, { + "val" : "Wikipedia:Locus_ceruleus" + }, { + "val" : "ZFA:0000539" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002149", + "lbl" : "superior salivatory nucleus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703).", + "xrefs" : [ "BIRNLEX:1131" ] + }, + "xrefs" : [ { + "val" : "BAMS:SSN" + }, { + "val" : "BAMS:SuS" + }, { + "val" : "BIRNLEX:1131" + }, { + "val" : "DHBA:12435" + }, { + "val" : "EHDAA2:0004646" + }, { + "val" : "FMA:72482" + }, { + "val" : "HBA:9194" + }, { + "val" : "MA:0001027" + }, { + "val" : "MBA:462" + }, { + "val" : "SCTID:369028007" + }, { + "val" : "Wikipedia:Superior_salivatory_nucleus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002165", + "lbl" : "endocardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO].", + "xrefs" : [ "GO:0003157" ] + }, + "comments" : [ "fixed in GO to reflect FMA. See email to David/Varsha June 18 2010" ], + "xrefs" : [ { + "val" : "AAO:0010408" + }, { + "val" : "BTO:0000387" + }, { + "val" : "CALOHA:TS-2075" + }, { + "val" : "EFO:0000821" + }, { + "val" : "EHDAA2:0004153" + }, { + "val" : "EMAPA:17868" + }, { + "val" : "EMAPA:32686" + }, { + "val" : "EV:0100021" + }, { + "val" : "FMA:7280" + }, { + "val" : "GAID:550" + }, { + "val" : "MA:0000076" + }, { + "val" : "MAT:0000455" + }, { + "val" : "MESH:D004699" + }, { + "val" : "NCIT:C13004" + }, { + "val" : "SCTID:362013006" + }, { + "val" : "TAO:0001320" + }, { + "val" : "VHOG:0000084" + }, { + "val" : "Wikipedia:Endocardium" + }, { + "val" : "XAO:0000066" + }, { + "val" : "ZFA:0001320" + }, { + "val" : "galen:Endocardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002166", + "lbl" : "endocardium of atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endocardium that is part of the atrium.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32745" + }, { + "val" : "FMA:7284" + }, { + "val" : "MA:0000077" + }, { + "val" : "SCTID:192001005" + }, { + "val" : "TAO:0002169" + }, { + "val" : "VHOG:0000606" + }, { + "val" : "ZFA:0001614" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002167", + "lbl" : "right lung", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA].", + "xrefs" : [ "FMA:FMA", "Wikipedia:Right_lung" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001730" + }, { + "val" : "EHDAA:4969" + }, { + "val" : "EMAPA:17661" + }, { + "val" : "FMA:7309" + }, { + "val" : "MA:0000426" + }, { + "val" : "NCIT:C33483" + }, { + "val" : "SCTID:361967000" + }, { + "val" : "VHOG:0000301" + }, { + "val" : "Wikipedia:Right_lung" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002168", + "lbl" : "left lung", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lung which consists of the left upper lobe and left lower lobe.[FMA].", + "xrefs" : [ "FMA:FMA", "Wikipedia:Left_lung" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000943" + }, { + "val" : "EHDAA:4947" + }, { + "val" : "EMAPA:17653" + }, { + "val" : "FMA:7310" + }, { + "val" : "MA:0000425" + }, { + "val" : "NCIT:C32967" + }, { + "val" : "SCTID:361982005" + }, { + "val" : "VHOG:0000618" + }, { + "val" : "Wikipedia:Left_lung" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002169", + "lbl" : "alveolar sac", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters.", + "xrefs" : [ "MP:0010902", "Wikipedia:Alveolar_sac" ] + }, + "xrefs" : [ { + "val" : "BTO:0000061" + }, { + "val" : "EMAPA:35119" + }, { + "val" : "FMA:7317" + }, { + "val" : "MA:0000418" + }, { + "val" : "NCIT:C32057" + }, { + "val" : "SCTID:361964007" + }, { + "val" : "Wikipedia:Alveolar_sac" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002173", + "lbl" : "pulmonary alveolar duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:cwg", "MP:0002271" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32694" + }, { + "val" : "FMA:7341" + }, { + "val" : "MA:0000417" + }, { + "val" : "NCIT:C32056" + }, { + "val" : "Wikipedia:Alveolar_duct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002185", + "lbl" : "bronchus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The upper conducting airways of the lung; these airways arise from the terminus of the trachea.", + "xrefs" : [ "ISBN:0-397-51047-0", "MESH:A04.411.125", "MGI:cwg", "MP:0002264" ] + }, + "xrefs" : [ { + "val" : "BTO:0001340" + }, { + "val" : "CALOHA:TS-1229" + }, { + "val" : "EFO:0000932" + }, { + "val" : "EMAPA:32689" + }, { + "val" : "EV:0100041" + }, { + "val" : "FMA:7409" + }, { + "val" : "GAID:346" + }, { + "val" : "MA:0000436" + }, { + "val" : "MAT:0000133" + }, { + "val" : "MESH:D001980" + }, { + "val" : "MIAA:0000133" + }, { + "val" : "NCIT:C12683" + }, { + "val" : "SCTID:181215002" + }, { + "val" : "VHOG:0000262" + }, { + "val" : "Wikipedia:Bronchus" + }, { + "val" : "XAO:0000121" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002186", + "lbl" : "bronchiole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching.", + "xrefs" : [ "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002267" ] + }, + "comments" : [ "In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole." ], + "xrefs" : [ { + "val" : "BTO:0002375" + }, { + "val" : "CALOHA:TS-2003" + }, { + "val" : "EHDAA:8171" + }, { + "val" : "EHDAA:8183" + }, { + "val" : "EHDAA:8199" + }, { + "val" : "EHDAA:8221" + }, { + "val" : "EMAPA:32697" + }, { + "val" : "FMA:7410" + }, { + "val" : "MA:0000422" + }, { + "val" : "NCIT:C12684" + }, { + "val" : "SCTID:278982001" + }, { + "val" : "VHOG:0000675" + }, { + "val" : "Wikipedia:Bronchiole" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002187", + "lbl" : "terminal bronchiole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls.", + "xrefs" : [ "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002268", "PMID:16543587" ] + }, + "xrefs" : [ { + "val" : "BTO:0003223" + }, { + "val" : "EMAPA:36282" + }, { + "val" : "FMA:7411" + }, { + "val" : "MA:0000424" + }, { + "val" : "NCIT:C33754" + }, { + "val" : "SCTID:278981008" + }, { + "val" : "Wikipedia:Terminal_bronchiole" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002188", + "lbl" : "respiratory bronchiole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bronchiole that is the first segment of the respiratory zone.", + "xrefs" : [ "ISBN:0123813611", "Wikipedia:Respiratory_bronchiole" ] + }, + "xrefs" : [ { + "val" : "BTO:0003222" + }, { + "val" : "EMAPA:35729" + }, { + "val" : "FMA:7412" + }, { + "val" : "MA:0000423" + }, { + "val" : "NCIT:C33465" + }, { + "val" : "SCTID:128517006" + }, { + "val" : "Wikipedia:Respiratory_bronchiole" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002190", + "lbl" : "subcutaneous adipose tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of adipose tissue that is part of the hypodermis, beneath the dermis.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004042" + }, { + "val" : "EMAPA:35829" + }, { + "val" : "FMA:74315" + }, { + "val" : "MA:0000473" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002193", + "lbl" : "hemolymphoid system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2018" + }, { + "val" : "EHDAA2:0004615" + }, { + "val" : "EMAPA:18765" + }, { + "val" : "FMA:74562" + }, { + "val" : "MA:0000013" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002199", + "lbl" : "integument", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dermis, epidermis and hypodermis.", + "xrefs" : [ "Wikipedia:Integument" ] + }, + "xrefs" : [ { + "val" : "AAO:0000239" + }, { + "val" : "BTO:0000634" + }, { + "val" : "FMA:74657" + }, { + "val" : "TAO:0000368" + }, { + "val" : "VSAO:0000029" + }, { + "val" : "Wikipedia:Integument" + }, { + "val" : "ZFA:0000368" + }, { + "val" : "galen:Integument" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002200", + "lbl" : "vasculature of head", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vasculature that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003656" + }, { + "val" : "FMA:74710" + }, { + "val" : "TAO:0001267" + }, { + "val" : "XAO:0004152" + }, { + "val" : "ZFA:0001267" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002201", + "lbl" : "vasculature of trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:74712" + }, { + "val" : "TAO:0005024" + }, { + "val" : "ZFA:0005024" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002202", + "lbl" : "submucosa of trachea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002115" + }, { + "val" : "EMAPA:35879" + }, { + "val" : "FMA:7472" + }, { + "val" : "MA:0001860" + }, { + "val" : "NCIT:C49307" + }, { + "val" : "SCTID:4419000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002203", + "lbl" : "vasculature of eye", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vasculature that is part of the eye region.", + "xrefs" : [ "OBOL:automatic", "https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726" ] + }, + "xrefs" : [ { + "val" : "FMA:74743" + }, { + "val" : "SCTID:123846009" + }, { + "val" : "TAO:0007057" + }, { + "val" : "ZFA:0007057" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002204", + "lbl" : "musculoskeletal system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that consists of the muscular and skeletal systems.", + "xrefs" : [ "VSAO:0000031", "VSAO:curator", "https://github.com/obophenotype/uberon/issues/77" ] + }, + "xrefs" : [ { + "val" : "AAO:0010546" + }, { + "val" : "CALOHA:TS-1311" + }, { + "val" : "EMAPA:32714" + }, { + "val" : "EV:0100139" + }, { + "val" : "FMA:7482" + }, { + "val" : "GAID:98" + }, { + "val" : "MA:0002418" + }, { + "val" : "MESH:D009141" + }, { + "val" : "NCIT:C12754" + }, { + "val" : "SCTID:278858007" + }, { + "val" : "VHOG:0001275" + }, { + "val" : "VSAO:0000031" + }, { + "val" : "Wikipedia:Musculoskeletal_system" + }, { + "val" : "XAO:0000168" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002213", + "lbl" : "cartilaginous joint", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA].", + "xrefs" : [ "FMA:FMA", "Wikipedia:Cartilaginous_joint" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36581" + }, { + "val" : "FMA:7496" + }, { + "val" : "MA:0000320" + }, { + "val" : "SCTID:58442004" + }, { + "val" : "TAO:0005155" + }, { + "val" : "Wikipedia:Cartilaginous_joint" + }, { + "val" : "ZFA:0005155" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002217", + "lbl" : "synovial joint", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA].", + "xrefs" : [ "FMA:7501", "Wikipedia:Synovial_joint" ] + }, + "xrefs" : [ { + "val" : "AEO:0000183" + }, { + "val" : "CALOHA:TS-2138" + }, { + "val" : "EHDAA2:0003183" + }, { + "val" : "FMA:7501" + }, { + "val" : "MA:0000322" + }, { + "val" : "NCIT:C32461" + }, { + "val" : "SCTID:113234001" + }, { + "val" : "TAO:0005153" + }, { + "val" : "Wikipedia:Synovial_joint" + }, { + "val" : "ZFA:0005153" + }, { + "val" : "galen:SynovialJoint" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002224", + "lbl" : "thoracic cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the coelemic cavity lumen that is enclosed by the walls of the thorax.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Thoracic_cavity" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36497" + }, { + "val" : "FMA:7565" + }, { + "val" : "GAID:93" + }, { + "val" : "MA:0000032" + }, { + "val" : "MESH:D035423" + }, { + "val" : "NCIT:C12905" + }, { + "val" : "SCTID:243949006" + }, { + "val" : "Wikipedia:Thoracic_cavity" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002240", + "lbl" : "spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).", + "xrefs" : [ "BIRNLEX:1709" ] + }, + "xrefs" : [ { + "val" : "AAO:0010151" + }, { + "val" : "BAMS:SP" + }, { + "val" : "BAMS:Spinal" + }, { + "val" : "BIRNLEX:1709" + }, { + "val" : "BM:SpC" + }, { + "val" : "BTO:0001279" + }, { + "val" : "CALOHA:TS-0953" + }, { + "val" : "DHBA:12890" + }, { + "val" : "DMBA:17651" + }, { + "val" : "EFO:0000110" + }, { + "val" : "EHDAA2:0001255" + }, { + "val" : "EHDAA:2863" + }, { + "val" : "EMAPA:17577" + }, { + "val" : "EV:0100316" + }, { + "val" : "FMA:7647" + }, { + "val" : "GAID:695" + }, { + "val" : "MA:0000216" + }, { + "val" : "MAT:0000183" + }, { + "val" : "MESH:D013116" + }, { + "val" : "MIAA:0000183" + }, { + "val" : "NCIT:C12464" + }, { + "val" : "SCTID:180959008" + }, { + "val" : "TAO:0000075" + }, { + "val" : "VHOG:0000601" + }, { + "val" : "Wikipedia:Spinal_cord" + }, { + "val" : "XAO:0000020" + }, { + "val" : "ZFA:0000075" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002241", + "lbl" : "chondrocranium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD].", + "xrefs" : [ "Wikipedia:Chondrocranium", "http://medical-dictionary.thefreedictionary.com/chondrocranium" ] + }, + "xrefs" : [ { + "val" : "AAO:0010169" + }, { + "val" : "EHDAA2:0000243" + }, { + "val" : "EMAPA:17681" + }, { + "val" : "TAO:0001424" + }, { + "val" : "VHOG:0000288" + }, { + "val" : "Wikipedia:Chondrocranium" + }, { + "val" : "ZFA:0001424" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002257", + "lbl" : "ventral horn of spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO].", + "xrefs" : [ "GO:0021517", "MP:0005112", "Wikipedia:Anterior_horn_of_spinal_cord", "https://sourceforge.net/tracker/?group_id=36855&atid=440764" ] + }, + "xrefs" : [ { + "val" : "BAMS:VH" + }, { + "val" : "BIRNLEX:2668" + }, { + "val" : "BTO:0005151" + }, { + "val" : "EMAPA:18575" + }, { + "val" : "EMAPA:35794" + }, { + "val" : "FMA:256541" + }, { + "val" : "MA:0001134" + }, { + "val" : "NCIT:C33859" + }, { + "val" : "SCTID:279443000" + }, { + "val" : "TAO:0000702" + }, { + "val" : "VHOG:0001288" + }, { + "val" : "Wikipedia:Anterior_horn_of_spinal_cord" + }, { + "val" : "ZFA:0000702" + }, { + "val" : "neuronames:1751" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002275", + "lbl" : "reticular formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ).", + "xrefs" : [ "NeuroNames:1223" ] + }, + "xrefs" : [ { + "val" : "BAMS:RET" + }, { + "val" : "EMAPA:35188" + }, { + "val" : "FMA:77719" + }, { + "val" : "MA:0003185" + }, { + "val" : "MESH:D012154" + }, { + "val" : "NLX:143558" + }, { + "val" : "SCTID:361552007" + }, { + "val" : "Wikipedia:Reticular_formation" + }, { + "val" : "neuronames:1223" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "lbl" : "biliary system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree).", + "xrefs" : [ "Wikipedia:Biliary_system" ] + }, + "xrefs" : [ { + "val" : "FMA:79646" + }, { + "val" : "GAID:279" + }, { + "val" : "MA:0001273" + }, { + "val" : "MESH:D001659" + }, { + "val" : "NCIT:C12678" + }, { + "val" : "SCTID:361354009" + }, { + "val" : "Wikipedia:Biliary_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002296", + "lbl" : "dorsal mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA].", + "xrefs" : [ "Wikipedia:Dorsal_mesentery", "Wikipedia:Mesentery#Development", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004560" + }, { + "val" : "EHDAA:3019" + }, { + "val" : "EHDAA:3033" + }, { + "val" : "EHDAA:3921" + }, { + "val" : "EHDAA:3934" + }, { + "val" : "EHDAA:3957" + }, { + "val" : "EHDAA:3971" + }, { + "val" : "FMA:79795" + }, { + "val" : "SCTID:308823000" + }, { + "val" : "TAO:0005130" + }, { + "val" : "Wikipedia:Mesentery#Development" + }, { + "val" : "ZFA:0005130" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002298", + "lbl" : "brainstem", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized].", + "xrefs" : [ "ISBN:0471888893", "MP:0005277", "Wikipedia:Brainstem", "ZFA:0001707" ] + }, + "comments" : [ "'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions)." ], + "xrefs" : [ { + "val" : "BAMS:BS" + }, { + "val" : "BIRNLEX:1565" + }, { + "val" : "BTO:0000146" + }, { + "val" : "CALOHA:TS-0093" + }, { + "val" : "EFO:0001962" + }, { + "val" : "EMAPA:32678" + }, { + "val" : "EV:0100241" + }, { + "val" : "FMA:79876" + }, { + "val" : "MA:0000169" + }, { + "val" : "MBA:343" + }, { + "val" : "MESH:D001933" + }, { + "val" : "NCIT:C12441" + }, { + "val" : "SCTID:180925009" + }, { + "val" : "TAO:0002156" + }, { + "val" : "VHOG:0001457" + }, { + "val" : "Wikipedia:Brainstem" + }, { + "val" : "ZFA:0001707" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002299", + "lbl" : "alveolus of lung", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP].", + "xrefs" : [ "Wikipedia:Pulmonary_alveolus" ] + }, + "xrefs" : [ { + "val" : "BTO:0000060" + }, { + "val" : "CALOHA:TS-0031" + }, { + "val" : "EFO:0001985" + }, { + "val" : "EMAPA:32682" + }, { + "val" : "FMA:7318" + }, { + "val" : "GAID:349" + }, { + "val" : "MA:0000420" + }, { + "val" : "MESH:D011650" + }, { + "val" : "SCTID:361364000" + }, { + "val" : "VHOG:0001445" + }, { + "val" : "Wikipedia:Pulmonary_alveolus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002302", + "lbl" : "myocardium of atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The atrial part of middle layer of the heart, comprised of involuntary muscle.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010493" ] + }, + "xrefs" : [ { + "val" : "EFO:0003087" + }, { + "val" : "EMAPA:32746" + }, { + "val" : "FMA:83509" + }, { + "val" : "MA:0000081" + }, { + "val" : "SCTID:191910002" + }, { + "val" : "TAO:0001374" + }, { + "val" : "VHOG:0000602" + }, { + "val" : "ZFA:0001374" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002308", + "lbl" : "nucleus of brain", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural nucleus that is part of the brain.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35185" + }, { + "val" : "FMA:83840" + }, { + "val" : "MA:0000811" + }, { + "val" : "NCIT:C49346" + }, { + "val" : "SCTID:426465002" + }, { + "val" : "ZFA:0005575" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002315", + "lbl" : "gray matter of spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue.", + "xrefs" : [ "MP:0008503" ] + }, + "xrefs" : [ { + "val" : "BAMS:Scgrey" + }, { + "val" : "DHBA:146035048" + }, { + "val" : "EMAPA:35792" + }, { + "val" : "FMA:256580" + }, { + "val" : "MA:0000002" + }, { + "val" : "NCIT:C32696" + }, { + "val" : "NLXANAT:100204" + }, { + "val" : "SCTID:279441003" + }, { + "val" : "neuronames:2619" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002323", + "lbl" : "coelemic cavity lumen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities.", + "xrefs" : [ "BTO:0001707" ] + }, + "comments" : [ "EDITOR_NOTE check the FMA placement here; ncit placement of body cavity here probably not correct" ], + "xrefs" : [ { + "val" : "AEO:0000186" + }, { + "val" : "BTO:0001707" + }, { + "val" : "EHDAA2:0000267" + }, { + "val" : "FMA:85006" + }, { + "val" : "NCIT:C25444" + }, { + "val" : "RETIRED_EHDAA2:0003186" + }, { + "val" : "SCTID:361348008" + }, { + "val" : "TAO:0001438" + }, { + "val" : "ZFA:0001438" + }, { + "val" : "galen:BodyCavity" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002324", + "lbl" : "muscle of back", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35161" + }, { + "val" : "FMA:85216" + }, { + "val" : "MA:0000496" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002328", + "lbl" : "notochord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube.", + "xrefs" : [ "ISBN:0815318960", "Wikipedia:Notochord", "http://tolweb.org/Chordata/2499", "https://github.com/obophenotype/uberon/issues/25", "https://github.com/obophenotype/uberon/issues/271" ] + }, + "comments" : [ "The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB]" ], + "xrefs" : [ { + "val" : "AAO:0000327" + }, { + "val" : "BTO:0001768" + }, { + "val" : "CALOHA:TS-0690" + }, { + "val" : "EHDAA2:0001277" + }, { + "val" : "EHDAA:1241" + }, { + "val" : "EHDAA:6021" + }, { + "val" : "EMAPA:16191" + }, { + "val" : "EV:0100002" + }, { + "val" : "FMA:85521" + }, { + "val" : "GAID:1311" + }, { + "val" : "MAT:0000281" + }, { + "val" : "MESH:D009672" + }, { + "val" : "NCIT:C12463" + }, { + "val" : "SCTID:308820002" + }, { + "val" : "TAO:0000135" + }, { + "val" : "VHOG:0000199" + }, { + "val" : "VSAO:0000032" + }, { + "val" : "Wikipedia:Notochord" + }, { + "val" : "XAO:0000055" + }, { + "val" : "ZFA:0000135" + }, { + "val" : "http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002329", + "lbl" : "somite", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.", + "xrefs" : [ "DOI:10.1111/j.1439-0426.2012.01987.x", "Wikipedia:Somite" ] + }, + "comments" : [ "When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248]" ], + "xrefs" : [ { + "val" : "AAO:0010569" + }, { + "val" : "AEO:0001015" + }, { + "val" : "BTO:0001558" + }, { + "val" : "EHDAA2:0003436" + }, { + "val" : "EHDAA:366" + }, { + "val" : "EHDAA:699" + }, { + "val" : "EMAPA:31169" + }, { + "val" : "FMA:85522" + }, { + "val" : "GAID:1306" + }, { + "val" : "MAT:0000068" + }, { + "val" : "MESH:D019170" + }, { + "val" : "MIAA:0000068" + }, { + "val" : "NCIT:C34302" + }, { + "val" : "TAO:0000155" + }, { + "val" : "VHOG:0000191" + }, { + "val" : "Wikipedia:Somite" + }, { + "val" : "XAO:0000058" + }, { + "val" : "ZFA:0000155" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002330", + "lbl" : "exocrine system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia].", + "xrefs" : [ "Wikipedia:Exocrine_gland" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2057" + }, { + "val" : "EHDAA2:0002225" + }, { + "val" : "EMAPA:35329" + }, { + "val" : "FMA:85539" + }, { + "val" : "MA:0002411" + }, { + "val" : "NCIT:C12957" + }, { + "val" : "Wikipedia:Exocrine_gland" + }, { + "val" : "WikipediaCategory:Exocrine_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002333", + "lbl" : "pulmonary trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arterial trunk which is continuous with the heart and branches into the pulmonary arteries.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001576" + }, { + "val" : "EHDAA:9831" + }, { + "val" : "EMAPA:17015" + }, { + "val" : "FMA:8612" + }, { + "val" : "MA:0002033" + }, { + "val" : "NCIT:C116918" + }, { + "val" : "VHOG:0001134" + }, { + "val" : "galen:PulmonaryTrunk" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002338", + "lbl" : "lamina propria of bronchus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35194" + }, { + "val" : "FMA:86619" + }, { + "val" : "MA:0001836" + }, { + "val" : "NCIT:C49212" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002342", + "lbl" : "neural crest", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].", + "xrefs" : [ "MP:0009846" ] + }, + "comments" : [ "Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells." ], + "xrefs" : [ { + "val" : "AAO:0010578" + }, { + "val" : "BTO:0001764" + }, { + "val" : "CALOHA:TS-0676" + }, { + "val" : "EHDAA2:0004419" + }, { + "val" : "EMAPA:32737" + }, { + "val" : "FMA:86666" + }, { + "val" : "GAID:1310" + }, { + "val" : "MAT:0000066" + }, { + "val" : "MESH:D009432" + }, { + "val" : "MIAA:0000066" + }, { + "val" : "NCIT:C34222" + }, { + "val" : "SCTID:361462002" + }, { + "val" : "VHOG:0000057" + }, { + "val" : "Wikipedia:Neural_crest" + }, { + "val" : "XAO:0000048" + }, { + "val" : "ZFA:0000045" + }, { + "val" : "neuronames:1366" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002343", + "lbl" : "abdomen musculature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Set of all muscles in abdomen.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:71294" + }, { + "val" : "FMA:86917" + }, { + "val" : "TAO:0001327" + }, { + "val" : "ZFA:0001327" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002345", + "lbl" : "descending thoracic aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.", + "xrefs" : [ "MP:0009868" ] + }, + "xrefs" : [ { + "val" : "EFO:0002527" + }, { + "val" : "EMAPA:18605" + }, { + "val" : "FMA:87217" + }, { + "val" : "MA:0002572" + }, { + "val" : "SCTID:181301002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002346", + "lbl" : "neurectoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Embryonic ectoderm that gives rise to nervous tissue.", + "xrefs" : [ "Wikipedia:Neuroectoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0011074" + }, { + "val" : "BILA:0000039" + }, { + "val" : "CALOHA:TS-1212" + }, { + "val" : "EHDAA2:0001248" + }, { + "val" : "EHDAA:1498" + }, { + "val" : "EHDAA:255" + }, { + "val" : "EMAPA:16073" + }, { + "val" : "EV:0100004" + }, { + "val" : "FMA:87657" + }, { + "val" : "MAT:0000176" + }, { + "val" : "MIAA:0000176" + }, { + "val" : "NCIT:C34228" + }, { + "val" : "TAO:0001120" + }, { + "val" : "VHOG:0000150" + }, { + "val" : "Wikipedia:Neuroectoderm" + }, { + "val" : "XAO:0000042" + }, { + "val" : "ZFA:0001120" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "lbl" : "thoracic vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thoracic vertebra endochondral element that is composed primarily of a bone tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18011" + }, { + "val" : "FMA:9139" + }, { + "val" : "GAID:244" + }, { + "val" : "MA:0000314" + }, { + "val" : "MESH:D013904" + }, { + "val" : "NCIT:C12798" + }, { + "val" : "SCTID:181821009" + }, { + "val" : "Wikipedia:Thoracic_vertebrae" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002348", + "lbl" : "epicardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "EDITOR_NOTE TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer." ], + "xrefs" : [ { + "val" : "AAO:0010409" + }, { + "val" : "EHDAA2:0002202" + }, { + "val" : "FMA:9461" + }, { + "val" : "NCIT:C13164" + }, { + "val" : "TAO:0005057" + }, { + "val" : "VHOG:0000119" + }, { + "val" : "Wikipedia:Epicardium" + }, { + "val" : "XAO:0000316" + }, { + "val" : "ZFA:0005057" + }, { + "val" : "galen:Epicardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002349", + "lbl" : "myocardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The middle layer of the heart, comprised mainly of striated cardiac muscle fibers.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0005329" ] + }, + "comments" : [ "EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium" ], + "xrefs" : [ { + "val" : "AAO:0010410" + }, { + "val" : "BSA:0000089" + }, { + "val" : "BTO:0000901" + }, { + "val" : "CALOHA:TS-0440" + }, { + "val" : "EFO:0000819" + }, { + "val" : "EHDAA2:0004150" + }, { + "val" : "EV:0100022" + }, { + "val" : "FMA:9462" + }, { + "val" : "GAID:173" + }, { + "val" : "MA:0000164" + }, { + "val" : "MAT:0000453" + }, { + "val" : "MESH:D009206" + }, { + "val" : "NCIT:C12371" + }, { + "val" : "RETIRED_EHDAA2:0001220" + }, { + "val" : "SCTID:362012001" + }, { + "val" : "TAO:0001319" + }, { + "val" : "VHOG:0000083" + }, { + "val" : "Wikipedia:Myocardium" + }, { + "val" : "XAO:0000065" + }, { + "val" : "ZFA:0001319" + }, { + "val" : "galen:Myocardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002350", + "lbl" : "conducting system of heart", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO].", + "xrefs" : [ "GO:0003161" ] + }, + "xrefs" : [ { + "val" : "EFO:0003909" + }, { + "val" : "EHDAA2:0004185" + }, { + "val" : "EMAPA:35428" + }, { + "val" : "EV:0100025" + }, { + "val" : "FMA:9476" + }, { + "val" : "MA:0000094" + }, { + "val" : "MESH:D006329" + }, { + "val" : "SCTID:281489000" + }, { + "val" : "TAO:0005063" + }, { + "val" : "VHOG:0001271" + }, { + "val" : "ZFA:0005063" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002351", + "lbl" : "sinoatrial node", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA].", + "xrefs" : [ "GO:0003163", "Wikipedia:Sinoatrial_node" ] + }, + "comments" : [ "WP:Heart states: \"The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.\". Note however that ZFA has SA node." ], + "xrefs" : [ { + "val" : "BTO:0004358" + }, { + "val" : "EHDAA2:0004184" + }, { + "val" : "EMAPA:35772" + }, { + "val" : "FMA:9477" + }, { + "val" : "GAID:561" + }, { + "val" : "MA:0000097" + }, { + "val" : "MESH:D012849" + }, { + "val" : "NCIT:C33555" + }, { + "val" : "SCTID:277687007" + }, { + "val" : "TAO:0005069" + }, { + "val" : "Wikipedia:Sinoatrial_node" + }, { + "val" : "ZFA:0005069" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002352", + "lbl" : "atrioventricular node", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Atrioventricular_node" ] + }, + "xrefs" : [ { + "val" : "BTO:0005689" + }, { + "val" : "EFO:0000276" + }, { + "val" : "EHDAA2:0004183" + }, { + "val" : "EMAPA:35153" + }, { + "val" : "FMA:9478" + }, { + "val" : "GAID:558" + }, { + "val" : "MA:0000095" + }, { + "val" : "MAT:0000498" + }, { + "val" : "MESH:D001283" + }, { + "val" : "NCIT:C32161" + }, { + "val" : "SCTID:277688002" + }, { + "val" : "TAO:0005070" + }, { + "val" : "VHOG:0001474" + }, { + "val" : "Wikipedia:Atrioventricular_node" + }, { + "val" : "ZFA:0005070" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002354", + "lbl" : "cardiac Purkinje fiber", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.", + "xrefs" : [ "GO:0003165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001735" + }, { + "val" : "EMAPA:35718" + }, { + "val" : "FMA:9492" + }, { + "val" : "GAID:560" + }, { + "val" : "MA:0000096" + }, { + "val" : "MESH:D011690" + }, { + "val" : "NCIT:C33430" + }, { + "val" : "Wikipedia:Purkinje_fiber" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002357", + "lbl" : "serous pericardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Serous membrane which is divided into parietal and visceral serous pericardium.", + "xrefs" : [ "Wikipedia:Serous_pericardium", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19030" + }, { + "val" : "FMA:9582" + }, { + "val" : "MA:0002739" + }, { + "val" : "SCTID:243954002" + }, { + "val" : "Wikipedia:Serous_pericardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002358", + "lbl" : "peritoneum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that lines the peritoneal cavity[VHOG,modified].", + "xrefs" : [ "VHOG:0001257" ] + }, + "xrefs" : [ { + "val" : "AAO:0010814" + }, { + "val" : "BTO:0001472" + }, { + "val" : "CALOHA:TS-2072" + }, { + "val" : "EV:0100087" + }, { + "val" : "FMA:9584" + }, { + "val" : "GAID:18" + }, { + "val" : "MA:0000449" + }, { + "val" : "MESH:D010537" + }, { + "val" : "NCIT:C12770" + }, { + "val" : "TAO:0005120" + }, { + "val" : "VHOG:0001257" + }, { + "val" : "Wikipedia:Peritoneum" + }, { + "val" : "XAO:0000139" + }, { + "val" : "ZFA:0005120" + }, { + "val" : "galen:Peritoneum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002359", + "lbl" : "fibrous pericardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA].", + "xrefs" : [ "FMA:9586" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19029" + }, { + "val" : "FMA:9586" + }, { + "val" : "MA:0002738" + }, { + "val" : "SCTID:243953008" + }, { + "val" : "Wikipedia:Fibrous_pericardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002365", + "lbl" : "exocrine gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas.", + "xrefs" : [ "Wikipedia:Exocrine_gland" ] + }, + "xrefs" : [ { + "val" : "AEO:0000097" + }, { + "val" : "BTO:0000765" + }, { + "val" : "CALOHA:TS-2012" + }, { + "val" : "EHDAA2:0003097" + }, { + "val" : "EMAPA:35327" + }, { + "val" : "FMA:9596" + }, { + "val" : "GAID:34" + }, { + "val" : "MA:0002564" + }, { + "val" : "MESH:D005088" + }, { + "val" : "NCIT:C12712" + }, { + "val" : "SCTID:115976003" + }, { + "val" : "Wikipedia:Exocrine_gland" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002368", + "lbl" : "endocrine gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified].", + "xrefs" : [ "Wikipedia:Endocrine_gland" ] + }, + "xrefs" : [ { + "val" : "AEO:0000098" + }, { + "val" : "BTO:0001488" + }, { + "val" : "CALOHA:TS-1300" + }, { + "val" : "EHDAA2:0003098" + }, { + "val" : "EMAPA:35999" + }, { + "val" : "FMA:9602" + }, { + "val" : "GAID:335" + }, { + "val" : "MA:0002563" + }, { + "val" : "MESH:D004702" + }, { + "val" : "NCIT:C12704" + }, { + "val" : "SCTID:40818001" + }, { + "val" : "Wikipedia:Endocrine_gland" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002371", + "lbl" : "bone marrow", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The soft tissue that fills the cavities of bones.", + "xrefs" : [ "MGI:cwg", "MP:0002397" ] + }, + "xrefs" : [ { + "val" : "AAO:0011007" + }, { + "val" : "BTO:0000141" + }, { + "val" : "BTO:0000829" + }, { + "val" : "CALOHA:TS-0087" + }, { + "val" : "EFO:0000868" + }, { + "val" : "EMAPA:32760" + }, { + "val" : "EV:0100046" + }, { + "val" : "FMA:9608" + }, { + "val" : "GAID:1287" + }, { + "val" : "MA:0000134" + }, { + "val" : "MAT:0000084" + }, { + "val" : "MESH:D001853" + }, { + "val" : "MIAA:0000084" + }, { + "val" : "NCIT:C12431" + }, { + "val" : "SCTID:421320006" + }, { + "val" : "VHOG:0001218" + }, { + "val" : "Wikipedia:Bone_marrow" + }, { + "val" : "XAO:0000123" + }, { + "val" : "galen:BoneMarrow" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002376", + "lbl" : "cranial muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any skeletal muscle that is part of the head region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984)" ], + "xrefs" : [ { + "val" : "AAO:0000107" + }, { + "val" : "BTO:0000021" + }, { + "val" : "EFO:0003524" + }, { + "val" : "EHDAA2:0000322" + }, { + "val" : "EMAPA:18172" + }, { + "val" : "FMA:9616" + }, { + "val" : "MA:0000578" + }, { + "val" : "SCTID:244718003" + }, { + "val" : "ZFA:0001652" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002377", + "lbl" : "muscle of neck", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle that is part of the cervical (neck) region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:9617" + }, { + "val" : "GAID:149" + }, { + "val" : "MA:0000587" + }, { + "val" : "MESH:D009334" + }, { + "val" : "NCIT:C33163" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002378", + "lbl" : "muscle of abdomen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis.", + "xrefs" : [ "Wikipedia:Abdominal_muscle" ] + }, + "xrefs" : [ { + "val" : "BTO:0001261" + }, { + "val" : "EMAPA:35103" + }, { + "val" : "FMA:9620" + }, { + "val" : "GAID:89" + }, { + "val" : "MA:0000520" + }, { + "val" : "MESH:D000009" + }, { + "val" : "NCIT:C32040" + }, { + "val" : "SCTID:361352008" + }, { + "val" : "Wikipedia:Abdominal_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002384", + "lbl" : "connective tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000017", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/23" ] + }, + "xrefs" : [ { + "val" : "AAO:0000098" + }, { + "val" : "BTO:0000421" + }, { + "val" : "CALOHA:TS-2009" + }, { + "val" : "EFO:0000952" + }, { + "val" : "EMAPA:35251" + }, { + "val" : "FMA:9640" + }, { + "val" : "GAID:100" + }, { + "val" : "MA:0000011" + }, { + "val" : "MAT:0000301" + }, { + "val" : "MESH:D003238" + }, { + "val" : "MIAA:0000301" + }, { + "val" : "NCIT:C12374" + }, { + "val" : "SCTID:361919005" + }, { + "val" : "TAO:0001641" + }, { + "val" : "VSAO:0000017" + }, { + "val" : "XAO:0001017" + }, { + "val" : "ZFA:0001632" + }, { + "val" : "galen:ConnectiveTissue" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002385", + "lbl" : "muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].", + "xrefs" : [ "GO:0060537", "Wikipedia:Muscle_tissue", "https://sourceforge.net/tracker/index.php?func=detail&aid=2801266&group_id=36855&atid=440764" ] + }, + "comments" : [ "Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach." ], + "xrefs" : [ { + "val" : "AAO:0000306" + }, { + "val" : "AEO:0000122" + }, { + "val" : "CALOHA:TS-0642" + }, { + "val" : "EHDAA2:0003122" + }, { + "val" : "EMAPA:32715" + }, { + "val" : "FMA:9641" + }, { + "val" : "MA:0002437" + }, { + "val" : "MESH:D009132" + }, { + "val" : "NCIT:C12435" + }, { + "val" : "SCTID:91727004" + }, { + "val" : "Wikipedia:Muscle_tissue" + }, { + "val" : "galen:MuscleTissue" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002390", + "lbl" : "hematopoietic system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that is involved in the production of hematopoietic cells.", + "xrefs" : [ "Wikipedia:Haematopoiesis" ] + }, + "xrefs" : [ { + "val" : "AAO:0011002" + }, { + "val" : "BTO:0000570" + }, { + "val" : "CALOHA:TS-0449" + }, { + "val" : "EFO:0000798" + }, { + "val" : "EMAPA:35402" + }, { + "val" : "EV:0100045" + }, { + "val" : "FMA:9667" + }, { + "val" : "GAID:1008" + }, { + "val" : "MA:0002434" + }, { + "val" : "MAT:0000022" + }, { + "val" : "MESH:D006413" + }, { + "val" : "MIAA:0000022" + }, { + "val" : "NCIT:C12909" + }, { + "val" : "SCTID:362587009" + }, { + "val" : "TAO:0005023" + }, { + "val" : "VHOG:0001624" + }, { + "val" : "Wikipedia:Haematopoiesis" + }, { + "val" : "XAO:0000122" + }, { + "val" : "ZFA:0005023" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "lbl" : "bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine.", + "xrefs" : [ "Wikipedia:Bile_duct", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011019" + }, { + "val" : "BTO:0000122" + }, { + "val" : "CALOHA:TS-0075" + }, { + "val" : "EMAPA:35171" + }, { + "val" : "EV:0100091" + }, { + "val" : "FMA:9706" + }, { + "val" : "GAID:280" + }, { + "val" : "MA:0000354" + }, { + "val" : "MESH:D001652" + }, { + "val" : "NCIT:C12376" + }, { + "val" : "SCTID:276157007" + }, { + "val" : "TAO:0001100" + }, { + "val" : "VHOG:0000212" + }, { + "val" : "Wikipedia:Bile_duct" + }, { + "val" : "XAO:0000134" + }, { + "val" : "ZFA:0001100" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "lbl" : "vomer", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The triangular flat bone of the nasal septum.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0000098" ] + }, + "xrefs" : [ { + "val" : "AAO:0000633" + }, { + "val" : "FMA:9710" + }, { + "val" : "MA:0001496" + }, { + "val" : "NCIT:C33888" + }, { + "val" : "SCTID:272678009" + }, { + "val" : "TAO:0000308" + }, { + "val" : "Wikipedia:Vomer" + }, { + "val" : "ZFA:0000308" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002400", + "lbl" : "parietal pleura", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outer serous membrane of the pulmonary pleural.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Pulmonary_pleurae" ] + }, + "comments" : [ "the part of the pleura external to the visceral pleura. It lines the inner surface of the chest wall, covers the diaphragm, and is reflected over the structures occupying the middle of the thorax" ], + "xrefs" : [ { + "val" : "EMAPA:16776" + }, { + "val" : "FMA:9733" + }, { + "val" : "MA:0002488" + }, { + "val" : "NCIT:C33273" + }, { + "val" : "SCTID:361998003" + }, { + "val" : "VHOG:0001495" + }, { + "val" : "Wikipedia:Parietal_pleura" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002401", + "lbl" : "visceral pleura", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Pulmonary_pleurae" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002205" + }, { + "val" : "EMAPA:16777" + }, { + "val" : "FMA:9734" + }, { + "val" : "MA:0002489" + }, { + "val" : "NCIT:C33881" + }, { + "val" : "SCTID:361997008" + }, { + "val" : "VHOG:0001496" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002402", + "lbl" : "pleural cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The fluid-filled cavity that lies between the visceral and parietal pleurae.", + "xrefs" : [ "Wikipedia:Pleural_cavity", "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "BTO:0004422" + }, { + "val" : "EHDAA2:0001475" + }, { + "val" : "EMAPA:16773" + }, { + "val" : "EMAPA:16774" + }, { + "val" : "FMA:9740" + }, { + "val" : "GAID:95" + }, { + "val" : "MA:0000055" + }, { + "val" : "MESH:D035422" + }, { + "val" : "NCIT:C12840" + }, { + "val" : "SCTID:361999006" + }, { + "val" : "VHOG:0000581" + }, { + "val" : "Wikipedia:Pleural_cavity" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002405", + "lbl" : "immune system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies.", + "xrefs" : [ "Wikipedia:Immune_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0011003" + }, { + "val" : "BILA:0000104" + }, { + "val" : "BTO:0005810" + }, { + "val" : "FMA:9825" + }, { + "val" : "GAID:328" + }, { + "val" : "MA:0002711" + }, { + "val" : "MESH:D007107" + }, { + "val" : "NCIT:C12735" + }, { + "val" : "SCTID:362590003" + }, { + "val" : "TAO:0001159" + }, { + "val" : "VHOG:0001247" + }, { + "val" : "Wikipedia:Immune_system" + }, { + "val" : "XAO:0003152" + }, { + "val" : "ZFA:0001159" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002406", + "lbl" : "pericardial sac", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A double-walled sac containing the heart and the roots of the great vessels.", + "xrefs" : [ "Wikipedia:Pericardium", "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "FMA:9868" + }, { + "val" : "RETIRED_EHDAA2:0001443" + }, { + "val" : "SCTID:361326002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002407", + "lbl" : "pericardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium.", + "xrefs" : [ "Wikipedia:Pericardium", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010817" + }, { + "val" : "BSA:0000090" + }, { + "val" : "BTO:0000717" + }, { + "val" : "CALOHA:TS-0761" + }, { + "val" : "EFO:0000820" + }, { + "val" : "EHDAA:5376" + }, { + "val" : "EV:0100023" + }, { + "val" : "FMA:9869" + }, { + "val" : "GAID:569" + }, { + "val" : "MA:0000099" + }, { + "val" : "MAT:0000454" + }, { + "val" : "MESH:D010496" + }, { + "val" : "NCIT:C13005" + }, { + "val" : "RETIRED_EHDAA2:0001443" + }, { + "val" : "SCTID:181295003" + }, { + "val" : "VHOG:0001280" + }, { + "val" : "Wikipedia:Pericardium" + }, { + "val" : "XAO:0004182" + }, { + "val" : "ZFA:0000054" + }, { + "val" : "galen:Pericardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002408", + "lbl" : "parietal serous pericardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA:3422" + }, { + "val" : "EHDAA:5378" + }, { + "val" : "EMAPA:19031" + }, { + "val" : "FMA:9870" + }, { + "val" : "MA:0000483" + }, { + "val" : "NCIT:C94500" + }, { + "val" : "SCTID:243956000" + }, { + "val" : "VHOG:0000537" + }, { + "val" : "Wikipedia:Parietal_pericardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002409", + "lbl" : "pericardial fluid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Transudate contained in the pericardial cavity.[FMA].", + "xrefs" : [ "FMA:9887", "Wikipedia:Pericardial_fluid" ] + }, + "xrefs" : [ { + "val" : "BTO:0001016" + }, { + "val" : "FMA:9887" + }, { + "val" : "MA:0002530" + }, { + "val" : "Wikipedia:Pericardial_fluid" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002410", + "lbl" : "autonomic nervous system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO].", + "xrefs" : [ "GO:0048483" ] + }, + "xrefs" : [ { + "val" : "AAO:0000033" + }, { + "val" : "BIRNLEX:1123" + }, { + "val" : "BTO:0002507" + }, { + "val" : "CALOHA:TS-2001" + }, { + "val" : "EHDA:10095" + }, { + "val" : "EHDAA2:0000158" + }, { + "val" : "EHDAA:3767" + }, { + "val" : "EMAPA:16984" + }, { + "val" : "FMA:65553" + }, { + "val" : "GAID:706" + }, { + "val" : "MA:0000219" + }, { + "val" : "MESH:D001341" + }, { + "val" : "NCIT:C12673" + }, { + "val" : "SCTID:362481007" + }, { + "val" : "TAO:0001574" + }, { + "val" : "VHOG:0000396" + }, { + "val" : "Wikipedia:Autonomic_nervous_system" + }, { + "val" : "ZFA:0001574" + }, { + "val" : "neuronames:2054" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "lbl" : "vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000691" + }, { + "val" : "CALOHA:TS-2352" + }, { + "val" : "EFO:0001371" + }, { + "val" : "EMAPA:32740" + }, { + "val" : "FMA:9914" + }, { + "val" : "MA:0000309" + }, { + "val" : "NCIT:C12933" + }, { + "val" : "SCTID:181817002" + }, { + "val" : "TAO:0001189" + }, { + "val" : "Wikipedia:Vertebra" + }, { + "val" : "XAO:0004019" + }, { + "val" : "ZFA:0001189" + }, { + "val" : "galen:Vertebra" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "lbl" : "cervical vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vertebra that is located in the cervical region of the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17674" + }, { + "val" : "FMA:9915" + }, { + "val" : "GAID:235" + }, { + "val" : "MA:0000311" + }, { + "val" : "MESH:D002574" + }, { + "val" : "NCIT:C12693" + }, { + "val" : "SCTID:181820005" + }, { + "val" : "Wikipedia:Cervical_vertebrae" + }, { + "val" : "XAO:0003076" + }, { + "val" : "galen:CervicalVertebra" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002415", + "lbl" : "tail", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail.", + "xrefs" : [ "AEO:0000109", "Wikipedia:Tail" ] + }, + "xrefs" : [ { + "val" : "AEO:0000109" + }, { + "val" : "BILA:0000117" + }, { + "val" : "BTO:0001348" + }, { + "val" : "EFO:0000963" + }, { + "val" : "EHDAA:9198" + }, { + "val" : "GAID:1245" + }, { + "val" : "MAT:0000094" + }, { + "val" : "MESH:D013623" + }, { + "val" : "MIAA:0000094" + }, { + "val" : "WBbt:0005741" + }, { + "val" : "Wikipedia:Tail" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002416", + "lbl" : "integumental system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle.", + "xrefs" : [ "CARO:0002001", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/29" ] + }, + "xrefs" : [ { + "val" : "AEO:0000154" + }, { + "val" : "BILA:0000118" + }, { + "val" : "CALOHA:TS-1299" + }, { + "val" : "CARO:0002001" + }, { + "val" : "EFO:0000807" + }, { + "val" : "EHDAA2:0000836" + }, { + "val" : "EHDAA2_RETIRED:0003154" + }, { + "val" : "EHDAA:6520" + }, { + "val" : "EMAPA:17524" + }, { + "val" : "EV:0100151" + }, { + "val" : "FMA:72979" + }, { + "val" : "HAO:0000421" + }, { + "val" : "MA:0000014" + }, { + "val" : "MAT:0000033" + }, { + "val" : "MESH:D034582" + }, { + "val" : "MIAA:0000033" + }, { + "val" : "NCIT:C12907" + }, { + "val" : "SCTID:361692004" + }, { + "val" : "TADS:0000108" + }, { + "val" : "VHOG:0000403" + }, { + "val" : "Wikipedia:Integumentary_system" + }, { + "val" : "XAO:0000176" + }, { + "val" : "galen:Surface" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002417", + "lbl" : "abdominal segment of trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The abdominal segment of the torso.", + "xrefs" : [ "Wikipedia:Lumbar" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35104" + }, { + "val" : "FMA:259211" + }, { + "val" : "MA:0000021" + }, { + "val" : "SCTID:362875007" + }, { + "val" : "Wikipedia:Lumbar" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002418", + "lbl" : "cartilage tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000040", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/37", "https://sourceforge.net/p/obo/vertebrate-skeletal-anatomy-vsao-term-requests/5" ] + }, + "comments" : [ "Previous: \"A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten].\" See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W]" ], + "xrefs" : [ { + "val" : "AAO:0000060" + }, { + "val" : "AEO:0000087" + }, { + "val" : "BTO:0000206" + }, { + "val" : "EFO:0000949" + }, { + "val" : "EHDAA2:0003087" + }, { + "val" : "EMAPA:32730" + }, { + "val" : "EV:0100141" + }, { + "val" : "FMA:37377" + }, { + "val" : "GAID:99" + }, { + "val" : "MA:0000104" + }, { + "val" : "MAT:0000189" + }, { + "val" : "MESH:D002356" + }, { + "val" : "MIAA:0000189" + }, { + "val" : "NCIT:C12373" + }, { + "val" : "NCIT:C32268" + }, { + "val" : "SCTID:309312004" + }, { + "val" : "TAO:0001501" + }, { + "val" : "VHOG:0001207" + }, { + "val" : "VSAO:0000040" + }, { + "val" : "Wikipedia:Cartilage" + }, { + "val" : "XAO:0000170" + }, { + "val" : "ZFA:0005622" + }, { + "val" : "galen:Cartilage" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001586", - "lbl" : "internal jugular vein", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002419", + "lbl" : "skin gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland that is part of a skin of body [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35774" + }, { + "val" : "FMA:71878" + }, { + "val" : "MA:0000146" + }, { + "val" : "SCTID:110485007" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001592", - "lbl" : "bronchial vein", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "lbl" : "hepatobiliary system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the digestive system that contains the liver and the biliary system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011056" + }, { + "val" : "CALOHA:TS-1308" + }, { + "val" : "EFO:0000800" + }, { + "val" : "EHDAA2:0000998" + }, { + "val" : "EHDAA:2189" + }, { + "val" : "EMAPA:16840" + }, { + "val" : "EV:0100088" + }, { + "val" : "MA:0000324" + }, { + "val" : "MAT:0000024" + }, { + "val" : "MIAA:0000024" + }, { + "val" : "NCIT:C43612" + }, { + "val" : "TAO:0000036" + }, { + "val" : "VHOG:0000294" + }, { + "val" : "Wikipedia:Hepatobiliary_system" + }, { + "val" : "XAO:0000132" + }, { + "val" : "ZFA:0000036" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001605", - "lbl" : "ciliary muscle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002424", + "lbl" : "oral epithelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010357" + }, { + "val" : "BTO:0001775" + }, { + "val" : "CALOHA:TS-0715" + }, { + "val" : "EHDAA2:0001325" + }, { + "val" : "EHDAA:2187" + }, { + "val" : "EMAPA:16839" + }, { + "val" : "EMAPA:26942" + }, { + "val" : "FMA:265152" + }, { + "val" : "MA:0000344" + }, { + "val" : "NCIT:C49595" + }, { + "val" : "TAO:0000816" + }, { + "val" : "VHOG:0000187" + }, { + "val" : "XAO:0003201" + }, { + "val" : "ZFA:0000816" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001606", - "lbl" : "muscle of iris", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001612", - "lbl" : "facial artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002425", + "lbl" : "visceral serous pericardium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA].", + "xrefs" : [ "Wikipedia:Visceral_pericardium" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19032" + }, { + "val" : "FMA:84882" + }, { + "val" : "MA:0000484" + }, { + "val" : "SCTID:243955001" + }, { + "val" : "VHOG:0000538" + }, { + "val" : "Wikipedia:Visceral_pericardium" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001630", - "lbl" : "muscle organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001637", - "lbl" : "artery", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001638", - "lbl" : "vein", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001645", - "lbl" : "trigeminal nerve", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002443", + "lbl" : "choroidal blood vessel", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A blood vessel that is part of a choroid [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "cannot find singular in FMA, using Set class" ], + "xrefs" : [ { + "val" : "EMAPA:17828" + }, { + "val" : "FMA:76550" + }, { + "val" : "MA:0001237" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001651", - "lbl" : "right pulmonary artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002457", + "lbl" : "intersomitic artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries.", + "xrefs" : [ "MP:0010662" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000882" + }, { + "val" : "EHDAA:4340" + }, { + "val" : "EMAPA:17616" + }, { + "val" : "MA:0001985" + }, { + "val" : "SCTID:360401001" + }, { + "val" : "TAO:0001061" + }, { + "val" : "VHOG:0000225" + }, { + "val" : "XAO:0004165" + }, { + "val" : "ZFA:0001061" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001652", - "lbl" : "left pulmonary artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002458", + "lbl" : "spinal artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Arteries that supply the spinal cord.", + "xrefs" : [ "Wikipedia:Spinal_artery", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001890" + }, { + "val" : "EHDAA:4355" + }, { + "val" : "EMAPA:18241" + }, { + "val" : "MA:0002043" + }, { + "val" : "NCIT:C33587" + }, { + "val" : "SCTID:244228006" + }, { + "val" : "TAO:0000682" + }, { + "val" : "Wikipedia:Spinal_artery" + }, { + "val" : "ZFA:0000682" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001653", - "lbl" : "facial vein", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002466", + "lbl" : "intestine secretion", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine.", + "xrefs" : [ "Wikipedia:Succus_entericus" ] + }, + "xrefs" : [ { + "val" : "BTO:0000644" + }, { + "val" : "FMA:62974" + }, { + "val" : "GAID:1162" + }, { + "val" : "MA:0002515" + }, { + "val" : "MESH:D007419" + }, { + "val" : "NCIT:C32875" + }, { + "val" : "Wikipedia:Succus_entericus" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001675", - "lbl" : "trigeminal ganglion", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001676", - "lbl" : "occipital bone", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002469", + "lbl" : "esophagus mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mucosa that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002859" + }, { + "val" : "EMAPA:26981" + }, { + "val" : "FMA:62996" + }, { + "val" : "MA:0002680" + }, { + "val" : "NCIT:C32538" + }, { + "val" : "SCTID:362127004" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001703", - "lbl" : "neurocranium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002481", + "lbl" : "bone tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000047", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2011" + }, { + "val" : "EMAPA:35179" + }, { + "val" : "FMA:224804" + }, { + "val" : "MA:0002780" + }, { + "val" : "MESH:D001842" + }, { + "val" : "NCIT:C13076" + }, { + "val" : "VSAO:0000047" + }, { + "val" : "Wikipedia:Bone_tissue" + }, { + "val" : "XAO:0004040" + }, { + "val" : "ZFA:0005621" + }, { + "val" : "galen:BoneTissue" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001708", - "lbl" : "jaw skeleton", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001710", - "lbl" : "lower jaw region", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001714", - "lbl" : "cranial ganglion", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002506", + "lbl" : "iris epithelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelium that is part of a iris [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35447" + }, { + "val" : "FMA:58517" + }, { + "val" : "MA:0002826" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001731", - "lbl" : "cavity of pharynx", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001766", - "lbl" : "anterior chamber of eyeball", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001768", - "lbl" : "uvea", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001769", - "lbl" : "iris", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002511", + "lbl" : "trabecula carnea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The supporting bundles of muscular fibers lining the walls of the ventricles of the heart.", + "xrefs" : [ "MGI:monikat", "MP:0004067" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18626" + }, { + "val" : "FMA:7269" + }, { + "val" : "MA:0002831" + }, { + "val" : "SCTID:118755002" + }, { + "val" : "Wikipedia:Trabeculae_carneae" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001772", - "lbl" : "corneal epithelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002513", + "lbl" : "endochondral bone", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Replacement bone that forms within cartilage.", + "xrefs" : [ "GO:0001958", "GO_REF:0000034", "VSAO:0000145", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/54" ] + }, + "xrefs" : [ { + "val" : "AAO:0010776" + }, { + "val" : "AEO:0000083" + }, { + "val" : "BTO:0002157" + }, { + "val" : "EHDAA2:0003083" + }, { + "val" : "FMA:24321" + }, { + "val" : "TAO:0001591" + }, { + "val" : "VSAO:0000145" + }, { + "val" : "XAO:0004018" + }, { + "val" : "ZFA:0001591" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001773", - "lbl" : "sclera", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002514", + "lbl" : "intramembranous bone", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].", + "xrefs" : [ "GO:0001957", "Wikipedia:Intramembranous_ossification", "https://github.com/obophenotype/uberon/issues/267" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36615" + }, { + "val" : "TAO:0001644" + }, { + "val" : "Wikipedia:Intramembranous_ossification" + }, { + "val" : "ZFA:0001635" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001774", - "lbl" : "skeletal muscle of trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001775", - "lbl" : "ciliary body", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002517", + "lbl" : "basicranium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof.", + "xrefs" : [ "Wikipedia:Base_of_skull" ] + }, + "comments" : [ "The skull base is formed from a series of cartilages either side of, and rostral to, the notochord, whose tip lies just caudal to the pituitary gland. It is closely associated with the sensory capsules, which partially or completely sur- round the olfactory epithelium, the eye, and the inner ear[PMID:11523816]" ], + "xrefs" : [ { + "val" : "FMA:52801" + }, { + "val" : "MA:0002840" + }, { + "val" : "MESH:D019291" + }, { + "val" : "MFMO:0000044" + }, { + "val" : "NCIT:C12493" + }, { + "val" : "SCTID:181890004" + }, { + "val" : "Wikipedia:Base_of_skull" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001776", - "lbl" : "optic choroid", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002521", + "lbl" : "elastic tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Connective tissue composed of elastic fibers.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:20113" + }, { + "val" : "GAID:926" + }, { + "val" : "MA:0002853" + }, { + "val" : "MESH:D004547" + }, { + "val" : "NCIT:C32495" + }, { + "val" : "SCTID:27197004" + }, { + "val" : "Wikipedia:Elastic_fiber" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001777", - "lbl" : "substantia propria of cornea", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001778", - "lbl" : "ciliary epithelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002522", + "lbl" : "tunica media", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The middle layer of an artery or vein. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Tunica_media" ] + }, + "comments" : [ "May be composed of smooth muscle and elastic tissue" ], + "xrefs" : [ { + "val" : "BTO:0002011" + }, { + "val" : "EMAPA:36298" + }, { + "val" : "FMA:55590" + }, { + "val" : "GAID:170" + }, { + "val" : "MA:0002855" + }, { + "val" : "MESH:D017540" + }, { + "val" : "NCIT:C33821" + }, { + "val" : "SCTID:61695000" + }, { + "val" : "Wikipedia:Tunica_media" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001779", - "lbl" : "iris stroma", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001780", - "lbl" : "spinal nerve", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002523", + "lbl" : "tunica intima", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong].", + "xrefs" : [ "ISBN:0073040584", "NCIT:C33820", "Wikipedia:Tunica_intima" ] + }, + "xrefs" : [ { + "val" : "BTO:0002012" + }, { + "val" : "EMAPA:36297" + }, { + "val" : "FMA:55589" + }, { + "val" : "GAID:523" + }, { + "val" : "MA:0002861" + }, { + "val" : "MESH:D017539" + }, { + "val" : "NCIT:C33820" + }, { + "val" : "SCTID:8361002" + }, { + "val" : "SCTID:87483006" + }, { + "val" : "Wikipedia:Tunica_intima" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001781", - "lbl" : "layer of retina", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001785", - "lbl" : "cranial nerve", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002530", + "lbl" : "gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An organ that functions as a secretory or excretory organ.", + "xrefs" : [ "MGI:csmith", "MP:0002163" ] + }, + "xrefs" : [ { + "val" : "AAO:0000212" + }, { + "val" : "AEO:0000096" + }, { + "val" : "BTO:0000522" + }, { + "val" : "EFO:0000797" + }, { + "val" : "EHDAA2:0003096" + }, { + "val" : "EHDAA:2161" + }, { + "val" : "EMAPA:18425" + }, { + "val" : "FMA:7146" + }, { + "val" : "FMA:86294" + }, { + "val" : "HAO:0000375" + }, { + "val" : "MA:0003038" + }, { + "val" : "MAT:0000021" + }, { + "val" : "MIAA:0000021" + }, { + "val" : "NCIT:C13319" + }, { + "val" : "SCTID:134358001" + }, { + "val" : "Wikipedia:Gland" + }, { + "val" : "WikipediaCategory:Glands" + }, { + "val" : "galen:Gland" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001796", - "lbl" : "aqueous humor of eyeball", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001800", - "lbl" : "sensory ganglion", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002532", + "lbl" : "epiblast (generic)", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA].", + "xrefs" : [ "Wikipedia:Epiblast", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "BTO:0004593" + }, { + "val" : "FMA:296704" + }, { + "val" : "MAT:0000067" + }, { + "val" : "MIAA:0000067" + }, { + "val" : "VHOG:0000243" + }, { + "val" : "Wikipedia:Epiblast" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001801", - "lbl" : "anterior segment of eyeball", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001802", - "lbl" : "posterior segment of eyeball", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001803", - "lbl" : "epithelium of lens", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002533", + "lbl" : "post-anal tail bud", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node.", + "xrefs" : [ "BTO:0001445" ] + }, + "xrefs" : [ { + "val" : "AAO:0011104" + }, { + "val" : "BTO:0001445" + }, { + "val" : "EFO:0002748" + }, { + "val" : "EHDAA2:0001976" + }, { + "val" : "EHDAA:1595" + }, { + "val" : "EMAPA:16580" + }, { + "val" : "MAT:0000070" + }, { + "val" : "MIAA:0000070" + }, { + "val" : "TAO:0000077" + }, { + "val" : "VHOG:0000201" + }, { + "val" : "XAO:0000107" + }, { + "val" : "ZFA:0000077" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001804", - "lbl" : "capsule of lens", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001805", - "lbl" : "autonomic ganglion", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002536", + "lbl" : "arthropod sensillum", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt].", + "xrefs" : [ "FBbt:00007152", "Wikipedia:Sensillum" ] + }, + "xrefs" : [ { + "val" : "BTO:0001237" + }, { + "val" : "EFO:0000939" + }, { + "val" : "HAO:0000933" + }, { + "val" : "MAT:0000163" + }, { + "val" : "MIAA:0000163" + }, { + "val" : "TGMA:0000540" + }, { + "val" : "Wikipedia:Sensillum" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001806", - "lbl" : "sympathetic ganglion", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001833", - "lbl" : "lip", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001835", - "lbl" : "lower lip", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001884", - "lbl" : "phrenic nerve", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002539", + "lbl" : "pharyngeal arch", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches.", + "xrefs" : [ "PMID:16313389", "ZFA:yb", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010359" + }, { + "val" : "BTO:0001785" + }, { + "val" : "EFO:0000959" + }, { + "val" : "EHDAA:571" + }, { + "val" : "EMAPA:16117" + }, { + "val" : "FMA:293015" + }, { + "val" : "GAID:1292" + }, { + "val" : "MAT:0000242" + }, { + "val" : "MESH:D001934" + }, { + "val" : "MIAA:0000242" + }, { + "val" : "NCIT:C34249" + }, { + "val" : "SCTID:308766004" + }, { + "val" : "TAO:0001306" + }, { + "val" : "VHOG:0000155" + }, { + "val" : "Wikipedia:Pharyngeal_arch" + }, { + "val" : "XAO:0000096" + }, { + "val" : "ZFA:0001306" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001891", - "lbl" : "midbrain", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002546", + "lbl" : "cranial placode", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic.", + "xrefs" : [ "http://www.ncbi.nlm.nih.gov/books/NBK53175/", "https://github.com/obophenotype/uberon/issues/135", "https://github.com/seger/aao/issues/4", "https://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/p/obo/xenopus-anatomy-xao-term-requests/11/" ] + }, + "xrefs" : [ { + "val" : "AAO:0010466" + }, { + "val" : "EFO:0001650" + }, { + "val" : "MAT:0000369" + }, { + "val" : "MIAA:0000369" + }, { + "val" : "XAO:0000305" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001892", - "lbl" : "rhombomere", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001895", - "lbl" : "metencephalon", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001896", - "lbl" : "medulla oblongata", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002553", + "lbl" : "anatomical cavity", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina.", + "xrefs" : [ "FMA:67552" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1011" + }, { + "val" : "FMA:67552" + }, { + "val" : "MA:0002447" + }, { + "val" : "NCIT:C34007" + }, { + "val" : "galen:Cavity" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001901", - "lbl" : "epithelium of trachea", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002558", + "lbl" : "organ cavity", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "BIRNLEX:1019" + }, { + "val" : "FMA:12237" + }, { + "val" : "SCTID:362606005" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001915", - "lbl" : "endothelium of capillary", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001916", - "lbl" : "endothelium of arteriole", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001917", - "lbl" : "endothelium of artery", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001918", - "lbl" : "endothelium of venule", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001919", - "lbl" : "endothelium of vein", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001943", - "lbl" : "midbrain tegmentum", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002561", + "lbl" : "lumen of central nervous system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1029" + }, { + "val" : "FMA:75007" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001948", - "lbl" : "regional part of spinal cord", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001955", - "lbl" : "epithelium of respiratory bronchiole", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002616", + "lbl" : "regional part of brain", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia.", + "xrefs" : [ "BIRNLEX:1167" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1167" + }, { + "val" : "FMA:55676" + }, { + "val" : "NCIT:C13031" + }, { + "val" : "SCTID:384763002" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001956", - "lbl" : "cartilage of bronchus", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002726", + "lbl" : "cervical spinal cord", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A spinal cord segment that adjacent_to a cervical region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1499" + }, { + "val" : "FMA:71166" + }, { + "val" : "MA:0003081" + }, { + "val" : "NCIT:C12892" + }, { + "val" : "SCTID:180960003" + }, { + "val" : "neuronames:1654" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001957", - "lbl" : "submucosa of bronchus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001958", - "lbl" : "terminal bronchiole epithelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002925", + "lbl" : "trigeminal nucleus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A nucleus of brain that is part of a trigeminal nuclear complex.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BM:V" + }, { + "val" : "BTO:0001074" + }, { + "val" : "CALOHA:TS-2077" + }, { + "val" : "EMAPA:35883" + }, { + "val" : "EV:0100271" + }, { + "val" : "FMA:71247" + }, { + "val" : "GAID:604" + }, { + "val" : "MA:0001028" + }, { + "val" : "MESH:D014278" + }, { + "val" : "NCIT:C12807" + }, { + "val" : "SCTID:280164007" + }, { + "val" : "VHOG:0001353" + }, { + "val" : "http://uri.neuinfo.org/nif/nifstd/nifext_11" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001969", - "lbl" : "blood plasma", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003023", + "lbl" : "pontine tegmentum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133).", + "xrefs" : [ "BIRNLEX:923" ] + }, + "xrefs" : [ { + "val" : "BAMS:PTg" + }, { + "val" : "BIRNLEX:923" + }, { + "val" : "DHBA:12416" + }, { + "val" : "FMA:71108" + }, { + "val" : "HBA:9135" + }, { + "val" : "SCTID:362401009" + }, { + "val" : "Wikipedia:Pontine_tegmentum" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001971", - "lbl" : "gastric juice", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003037", + "lbl" : "septum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A wall, dividing a cavity or structure into smaller ones[WP].", + "xrefs" : [ "Wikipedia:Septum" ] + }, + "comments" : [ "general anatomical term in FMA" ], + "xrefs" : [ { + "val" : "AAO:0011127" + }, { + "val" : "FMA:86461" + }, { + "val" : "Wikipedia:Septum" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001972", - "lbl" : "submucosa of esophagus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003038", + "lbl" : "thoracic spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Thoracic_spinal_cord" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:966" + }, { + "val" : "FMA:71167" + }, { + "val" : "MA:0003082" + }, { + "val" : "NCIT:C12894" + }, { + "val" : "SCTID:278750009" + }, { + "val" : "Wikipedia:Thoracic_spinal_cord" + }, { + "val" : "neuronames:1718" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001974", - "lbl" : "lamina propria of esophagus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003052", + "lbl" : "midbrain-hindbrain boundary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate.", + "xrefs" : [ "GO:0021555" ] + }, + "xrefs" : [ { + "val" : "AAO:0011064" + }, { + "val" : "DMBA:16810" + }, { + "val" : "EHDAA2:0004395" + }, { + "val" : "EHDAA:5789" + }, { + "val" : "EMAPA:32857" + }, { + "val" : "NCIT:C93172" + }, { + "val" : "TAO:0000042" + }, { + "val" : "VHOG:0000649" + }, { + "val" : "XAO:0000016" + }, { + "val" : "ZFA:0000042" + }, { + "val" : "neuronames:2076" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001975", - "lbl" : "serosa of esophagus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003055", + "lbl" : "periderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm.", + "xrefs" : [ "ISBN:9780878932504", "PMID:25133425", "PMID:35582825" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001846" + }, { + "val" : "EHDAA:6538" + }, { + "val" : "FMA:295662" + }, { + "val" : "NCIT:C34247" + }, { + "val" : "TAO:0001185" + }, { + "val" : "VHOG:0001680" + }, { + "val" : "XAO:0000029" + }, { + "val" : "ZFA:0001185" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001976", - "lbl" : "epithelium of esophagus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003056", + "lbl" : "pre-chordal neural plate", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of neural plate anterior to the mid-hindbrain junction.", + "xrefs" : [ "XB:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011084" + }, { + "val" : "TAO:0007016" + }, { + "val" : "VHOG:0001200" + }, { + "val" : "XAO:0000045" + }, { + "val" : "ZFA:0007016" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001979", - "lbl" : "venule", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003057", + "lbl" : "chordal neural plate", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The portion of neural plate posterior to the mid-hindbrain junction.", + "xrefs" : [ "XB:curator" ] + }, + "xrefs" : [ { + "val" : "TAO:0007017" + }, { + "val" : "VHOG:0001201" + }, { + "val" : "XAO:0000046" + }, { + "val" : "ZFA:0007017" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001980", - "lbl" : "arteriole", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003059", + "lbl" : "presomitic mesoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011086" + }, { + "val" : "EFO:0001982" + }, { + "val" : "EMAPA:16189" + }, { + "val" : "EMAPA:16752" + }, { + "val" : "TAO:0000279" + }, { + "val" : "VHOG:0000559" + }, { + "val" : "XAO:0000057" + }, { + "val" : "ZFA:0000279" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001981", - "lbl" : "blood vessel", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003061", + "lbl" : "blood island", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted].", + "xrefs" : [ "Wikipedia:Blood_island_of_umbilical_vesicle" ] + }, + "xrefs" : [ { + "val" : "AAO:0011006" + }, { + "val" : "EFO:0003489" + }, { + "val" : "EHDAA:207" + }, { + "val" : "NCIT:C34113" + }, { + "val" : "TAO:0000094" + }, { + "val" : "TE:E5.11.2.0.0.0.4" + }, { + "val" : "VHOG:0000085" + }, { + "val" : "Wikipedia:Blood_island_of_umbilical_vesicle" + }, { + "val" : "XAO:0000067" + }, { + "val" : "ZFA:0000094" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001982", - "lbl" : "capillary", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003063", + "lbl" : "prechordal plate", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue.", + "xrefs" : [ "ISBN:0838580343", "MP:0004387" ] + }, + "xrefs" : [ { + "val" : "AAO:0011085" + }, { + "val" : "EHDAA2:0001493" + }, { + "val" : "EHDAA:181" + }, { + "val" : "FMA:295532" + }, { + "val" : "TAO:0000060" + }, { + "val" : "VHOG:0000086" + }, { + "val" : "Wikipedia:Prechordal_plate" + }, { + "val" : "XAO:0000079" + }, { + "val" : "ZFA:0000060" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001985", - "lbl" : "corneal endothelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003064", + "lbl" : "intermediate mesoderm", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.", + "xrefs" : [ "GOC:curators", "Wikipedia:Intermediate_mesoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0010575" + }, { + "val" : "EMAPA:16056" + }, { + "val" : "EMAPA:16178" + }, { + "val" : "FMA:293147" + }, { + "val" : "NCIT:C34193" + }, { + "val" : "SCTID:361476001" + }, { + "val" : "TAO:0001206" + }, { + "val" : "VHOG:0000087" + }, { + "val" : "Wikipedia:Intermediate_mesoderm" + }, { + "val" : "XAO:0000085" + }, { + "val" : "ZFA:0001206" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001986", - "lbl" : "endothelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003067", + "lbl" : "dorsolateral placode", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Lateral neurogenic placodes positioned dorsal of the epibranchial placodes.", + "xrefs" : [ "ZFIN:curator" ] + }, + "comments" : [ "The only remaining dorsolateral placode in land vertebrates is the otic/octaval placode" ], + "xrefs" : [ { + "val" : "TAO:0001310" + }, { + "val" : "VHOG:0000103" + }, { + "val" : "XAO:0000187" + }, { + "val" : "ZFA:0001310" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001994", - "lbl" : "hyaline cartilage tissue", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003068", + "lbl" : "axial mesoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.", + "xrefs" : [ "GO:0048318", "Wikipedia:Chordamesoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0011017" + }, { + "val" : "EFO:0003647" + }, { + "val" : "TAO:0001204" + }, { + "val" : "VHOG:0000107" + }, { + "val" : "Wikipedia:Chordamesoderm" + }, { + "val" : "XAO:0000205" + }, { + "val" : "ZFA:0001204" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002012", - "lbl" : "pulmonary artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003070", + "lbl" : "trigeminal placode complex", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion.", + "xrefs" : [ "PMID:22512454", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/693" ] + }, + "xrefs" : [ { + "val" : "EFO:0003433" + }, { + "val" : "EHDAA2:0004209" + }, { + "val" : "TAO:0000162" + }, { + "val" : "VHOG:0000109" + }, { + "val" : "XAO:0000225" + }, { + "val" : "ZFA:0000162" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002016", - "lbl" : "pulmonary vein", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003071", + "lbl" : "eye primordium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles.", + "xrefs" : [ "GO:0046619", "ZFA:0000570" ] + }, + "xrefs" : [ { + "val" : "AAO:0011038" + }, { + "val" : "EFO:0003541" + }, { + "val" : "EHDAA2:0004431" + }, { + "val" : "TAO:0000570" + }, { + "val" : "XAO:0000227" + }, { + "val" : "XAO:0004090" + }, { + "val" : "ZFA:0000570" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002020", - "lbl" : "gray matter", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003072", + "lbl" : "optic cup", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP].", + "xrefs" : [ "MP:0004269", "Wikipedia:Optic_cup_(embryology)", "ZFA:0001202" ] + }, + "xrefs" : [ { + "val" : "BTO:0005351" + }, { + "val" : "EHDAA2:0001303" + }, { + "val" : "EHDAA:2912" + }, { + "val" : "EMAPA:16674" + }, { + "val" : "NCIT:C34233" + }, { + "val" : "SCTID:308789007" + }, { + "val" : "TAO:0001202" + }, { + "val" : "VHOG:0000167" + }, { + "val" : "ZFA:0001202" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002028", - "lbl" : "hindbrain", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003073", + "lbl" : "lens placode", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP].", + "xrefs" : [ "Wikipedia:Lens_placode", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011055" + }, { + "val" : "EFO:0003494" + }, { + "val" : "EHDAA2:0000982" + }, { + "val" : "EHDAA:2908" + }, { + "val" : "EMAPA:16672" + }, { + "val" : "FMA:296767" + }, { + "val" : "NCIT:C34202" + }, { + "val" : "TAO:0000122" + }, { + "val" : "VHOG:0000166" + }, { + "val" : "Wikipedia:Lens_placode" + }, { + "val" : "XAO:0000240" + }, { + "val" : "ZFA:0000122" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002031", - "lbl" : "epithelium of bronchus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003075", + "lbl" : "neural plate", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].", + "xrefs" : [ "ISBN:0815318960", "OMD:neural+plate", "Wikipedia:Neural_plate", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011072" + }, { + "val" : "BTO:0001765" + }, { + "val" : "DHBA:10153" + }, { + "val" : "DMBA:15565" + }, { + "val" : "EHDAA:346" + }, { + "val" : "EHDAA:902" + }, { + "val" : "EMAPA:35593" + }, { + "val" : "FMA:293879" + }, { + "val" : "NCIT:C34225" + }, { + "val" : "RETIRED_EHDAA2:0001252" + }, { + "val" : "TAO:0000132" + }, { + "val" : "VHOG:0000068" + }, { + "val" : "Wikipedia:Neural_plate" + }, { + "val" : "XAO:0000249" + }, { + "val" : "ZFA:0000132" + }, { + "val" : "neuronames:1362" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002036", - "lbl" : "striated muscle tissue", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003076", + "lbl" : "posterior neural tube", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "AAO:0011082" + }, { + "val" : "TAO:0007037" + }, { + "val" : "VHOG:0001383" + }, { + "val" : "XAO:0000250" + }, { + "val" : "ZFA:0007037" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002040", - "lbl" : "bronchial artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003077", + "lbl" : "paraxial mesoderm", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].", + "xrefs" : [ "GO:0048339", "https://github.com/obophenotype/uberon/issues/30" ] + }, + "xrefs" : [ { + "val" : "AAO:0010568" + }, { + "val" : "EFO:0003515" + }, { + "val" : "EMAPA:16183" + }, { + "val" : "EMAPA:16751" + }, { + "val" : "FMA:293145" + }, { + "val" : "NCIT:C34244" + }, { + "val" : "SCTID:361475002" + }, { + "val" : "TAO:0000255" + }, { + "val" : "VHOG:0000114" + }, { + "val" : "Wikipedia:Paraxial_mesoderm" + }, { + "val" : "XAO:0000259" + }, { + "val" : "ZFA:0000255" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002047", - "lbl" : "pontine raphe nucleus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003078", + "lbl" : "epibranchial placode", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia.", + "xrefs" : [ "VHOG:0000117" ] + }, + "xrefs" : [ { + "val" : "AAO:0011036" + }, { + "val" : "EFO:0003455" + }, { + "val" : "FMA:293968" + }, { + "val" : "TAO:0001294" + }, { + "val" : "VHOG:0000117" + }, { + "val" : "XAO:0000284" + }, { + "val" : "ZFA:0001294" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002048", - "lbl" : "lung", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003080", + "lbl" : "anterior neural tube", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "AAO:0011012" + }, { + "val" : "TAO:0007038" + }, { + "val" : "VHOG:0001384" + }, { + "val" : "XAO:0000307" + }, { + "val" : "ZFA:0007038" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002049", - "lbl" : "vasculature", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003081", + "lbl" : "lateral plate mesoderm", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP].", + "xrefs" : [ "MP:0010117", "Wikipedia:Lateral_plate_mesoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0010574" + }, { + "val" : "EHDAA2:0000919" + }, { + "val" : "EHDAA:379" + }, { + "val" : "EMAPA:16179" + }, { + "val" : "FMA:293149" + }, { + "val" : "NCIT:C34199" + }, { + "val" : "SCTID:361477005" + }, { + "val" : "TAO:0000121" + }, { + "val" : "VHOG:0000118" + }, { + "val" : "Wikipedia:Lateral_plate_mesoderm" + }, { + "val" : "XAO:0000311" + }, { + "val" : "ZFA:0000121" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002050", - "lbl" : "embryonic structure", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003082", + "lbl" : "myotome", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells.", + "xrefs" : [ "AEO:0001018" ] + }, + "xrefs" : [ { + "val" : "AAO:0011067" + }, { + "val" : "AEO:0001018" + }, { + "val" : "BTO:0000742" + }, { + "val" : "EHDAA2_RETIRED:0003431" + }, { + "val" : "EHDAA:1721" + }, { + "val" : "EHDAA:1727" + }, { + "val" : "EHDAA:1733" + }, { + "val" : "EHDAA:1739" + }, { + "val" : "EMAPA:32841" + }, { + "val" : "FMA:295658" + }, { + "val" : "NCIT:C34214" + }, { + "val" : "SCTID:344535001" + }, { + "val" : "TAO:0001056" + }, { + "val" : "VHOG:0001244" + }, { + "val" : "Wikipedia:Myotome" + }, { + "val" : "XAO:0000315" + }, { + "val" : "ZFA:0001056" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002051", - "lbl" : "epithelium of bronchiole", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003083", + "lbl" : "trunk neural crest", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia].", + "xrefs" : [ "ISBN:0815318960", "Wikipedia:Trunk_neural_crest" ] + }, + "xrefs" : [ { + "val" : "AAO:0010582" + }, { + "val" : "EFO:0003605" + }, { + "val" : "EHDAA2:0001901" + }, { + "val" : "TAO:0001024" + }, { + "val" : "VHOG:0000062" + }, { + "val" : "Wikipedia:Trunk_neural_crest" + }, { + "val" : "XAO:0000319" + }, { + "val" : "ZFA:0001024" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002057", - "lbl" : "phrenic artery", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003084", + "lbl" : "heart primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011044" + }, { + "val" : "BTO:0001887" + }, { + "val" : "NCIT:C34276" + }, { + "val" : "TAO:0000028" + }, { + "val" : "XAO:0000336" + }, { + "val" : "ZFA:0000028" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002061", - "lbl" : "truncus arteriosus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "lbl" : "caudal artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Extension of the dorsal aorta in the tail.", + "xrefs" : [ "Wikipedia:Caudal_artery", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011023" + }, { + "val" : "EFO:0003472" + }, { + "val" : "TAO:0000011" + }, { + "val" : "VHOG:0000123" + }, { + "val" : "Wikipedia:Caudal_artery" + }, { + "val" : "XAO:0000364" + }, { + "val" : "ZFA:0000011" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002062", - "lbl" : "endocardial cushion", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003089", + "lbl" : "sclerotome", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].", + "xrefs" : [ "Wikipedia:Sclerotome", "XB:curator", "https://github.com/obophenotype/uberon/issues/316" ] + }, + "xrefs" : [ { + "val" : "AAO:0010571" + }, { + "val" : "AEO:0000212" + }, { + "val" : "EHDAA2:0003439" + }, { + "val" : "EMAPA:31159" + }, { + "val" : "FMA:295652" + }, { + "val" : "NCIT:C34287" + }, { + "val" : "TAO:0001080" + }, { + "val" : "VHOG:0000680" + }, { + "val" : "Wikipedia:Sclerotome" + }, { + "val" : "XAO:0000397" + }, { + "val" : "ZFA:0001080" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002063", - "lbl" : "sinus venosus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003099", + "lbl" : "cranial neural crest", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage.", + "xrefs" : [ "MGI:anna" ] + }, + "xrefs" : [ { + "val" : "AAO:0010580" + }, { + "val" : "EFO:0003645" + }, { + "val" : "EHDAA2:0004420" + }, { + "val" : "EMAPA:16091" + }, { + "val" : "TAO:0001194" + }, { + "val" : "VHOG:0000063" + }, { + "val" : "Wikipedia:Cranial_neural_crest" + }, { + "val" : "XAO:0001001" + }, { + "val" : "ZFA:0001194" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002067", - "lbl" : "dermis", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003100", + "lbl" : "female organism", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Gonochoristic organism that can produce female gametes.", + "xrefs" : [ "CARO:0000028" ] + }, + "xrefs" : [ { + "val" : "AAO:0010030" + }, { + "val" : "BILA:0000028" + }, { + "val" : "CARO:0000028" + }, { + "val" : "FMA:67812" + }, { + "val" : "HAO:0000028" + }, { + "val" : "SCTID:362608006" + }, { + "val" : "TAO:0000303" + }, { + "val" : "TGMA:0001839" + }, { + "val" : "XAO:0003005" + }, { + "val" : "ZFA:0000303" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002072", - "lbl" : "hypodermis", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003102", + "lbl" : "surface structure", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/24" ] + }, + "xrefs" : [ { + "val" : "AAO:0010337" + }, { + "val" : "AEO_RETIRED:0000010" + }, { + "val" : "EHDAA2_RETIRED:0003010" + }, { + "val" : "TAO:0000292" + }, { + "val" : "VSAO:0000001" + }, { + "val" : "Wikipedia:Surface_structure" + }, { + "val" : "XAO:0003028" + }, { + "val" : "ZFA:0000292" + }, { + "val" : "galen:SurfaceRegion" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002075", - "lbl" : "viscus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002078", - "lbl" : "right cardiac atrium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003103", + "lbl" : "compound organ", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types.", + "xrefs" : [ "CARO:0000024" ] + }, + "xrefs" : [ { + "val" : "AAO:0010015" + }, { + "val" : "AEO:0000024" + }, { + "val" : "BILA:0000024" + }, { + "val" : "CARO:0000024" + }, { + "val" : "EHDAA2:0003024" + }, { + "val" : "HAO:0000024" + }, { + "val" : "TADS:0000598" + }, { + "val" : "TAO:0000496" + }, { + "val" : "TGMA:0001837" + }, { + "val" : "VHOG:0001723" + }, { + "val" : "XAO:0003041" + }, { + "val" : "ZFA:0000496" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002079", - "lbl" : "left cardiac atrium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003104", + "lbl" : "mesenchyme", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme.", + "xrefs" : [ "https://archive.org/details/invertebratesnde00brus/page/n240/mode/2up", "https://en.wikipedia.org/wiki/Mesenchyme", "https://github.com/obophenotype/uberon/issues/1641" ] + }, + "xrefs" : [ { + "val" : "AAO:0010427" + }, { + "val" : "AEO:0000145" + }, { + "val" : "BTO:0001393" + }, { + "val" : "CALOHA:TS-0620" + }, { + "val" : "EHDAA2:0003145" + }, { + "val" : "EV:0100007" + }, { + "val" : "NCIT:C13301" + }, { + "val" : "TAO:0000393" + }, { + "val" : "VHOG:0000170" + }, { + "val" : "Wikipedia:Mesenchyme" + }, { + "val" : "XAO:0003046" + }, { + "val" : "ZFA:0000393" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002080", - "lbl" : "heart right ventricle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003112", + "lbl" : "olfactory region", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ.", + "xrefs" : [ "TAO:0000351" ] + }, + "xrefs" : [ { + "val" : "AAO:0010206" + }, { + "val" : "EFO:0003525" + }, { + "val" : "NCIT:C98765" + }, { + "val" : "TAO:0000351" + }, { + "val" : "XAO:0003172" + }, { + "val" : "ZFA:0000351" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002081", - "lbl" : "cardiac atrium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002082", - "lbl" : "cardiac ventricle", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002084", - "lbl" : "heart left ventricle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003113", + "lbl" : "dermatocranium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified].", + "xrefs" : [ "Wikipedia:Skull_roof", "ZFA:0000863" ] + }, + "xrefs" : [ { + "val" : "AAO:0010154" + }, { + "val" : "TAO:0000863" + }, { + "val" : "VHOG:0001665" + }, { + "val" : "Wikipedia:Skull_roof" + }, { + "val" : "XAO:0003169" + }, { + "val" : "ZFA:0000863" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002085", - "lbl" : "interatrial septum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002090", - "lbl" : "postcranial axial skeleton", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002091", - "lbl" : "appendicular skeleton", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003115", + "lbl" : "pharyngeal arch 4", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus.", + "xrefs" : [ "MP:0006340" ] + }, + "xrefs" : [ { + "val" : "AAO:0010366" + }, { + "val" : "EHDAA2:0000086" + }, { + "val" : "EHDAA:1663" + }, { + "val" : "EMAPA:16760" + }, { + "val" : "FMA:293035" + }, { + "val" : "SCTID:308770007" + }, { + "val" : "TAO:0001599" + }, { + "val" : "VHOG:0000299" + }, { + "val" : "XAO:0000449" + }, { + "val" : "ZFA:0001607" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002094", - "lbl" : "interventricular septum", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003117", + "lbl" : "pharyngeal arch 6", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles.", + "xrefs" : [ "MP:0006347" ] + }, + "xrefs" : [ { + "val" : "AAO:0010368" + }, { + "val" : "EHDAA2:0004075" + }, { + "val" : "EMAPA:32766" + }, { + "val" : "FMA:293047" + }, { + "val" : "SCTID:308772004" + }, { + "val" : "TAO:0001601" + }, { + "val" : "VHOG:0001205" + }, { + "val" : "XAO:0000453" + }, { + "val" : "ZFA:0001609" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002097", - "lbl" : "skin of body", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003118", + "lbl" : "pharyngeal arch artery 1", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The vessels formed within the first pair of branchial arches in embryogenesis.", + "xrefs" : [ "MP:0010355" ] + }, + "xrefs" : [ { + "val" : "AAO:0010415" + }, { + "val" : "EHDAA2:0000007" + }, { + "val" : "EMAPA:16202" + }, { + "val" : "EMAPA:16685" + }, { + "val" : "SCTID:308774003" + }, { + "val" : "TAO:0005005" + }, { + "val" : "VHOG:0000149" + }, { + "val" : "XAO:0000342" + }, { + "val" : "ZFA:0005005" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002099", - "lbl" : "cardiac septum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002100", - "lbl" : "trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002104", - "lbl" : "visual system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002105", - "lbl" : "vestibulo-auditory system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002111", - "lbl" : "artery smooth muscle tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002112", - "lbl" : "smooth muscle of esophagus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002118", - "lbl" : "right ovary", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002119", - "lbl" : "left ovary", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002128", - "lbl" : "superior olivary complex", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002148", - "lbl" : "locus ceruleus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002149", - "lbl" : "superior salivatory nucleus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002165", - "lbl" : "endocardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002166", - "lbl" : "endocardium of atrium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002167", - "lbl" : "right lung", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002168", - "lbl" : "left lung", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002169", - "lbl" : "alveolar sac", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002173", - "lbl" : "pulmonary alveolar duct", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003121", + "lbl" : "pharyngeal arch artery 4", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The vessels formed within the fourth pair of branchial arches in embryogenesis.", + "xrefs" : [ "MP:0006354" ] + }, + "comments" : [ "proximal right subclavian" ], + "xrefs" : [ { + "val" : "AAO:0010420" + }, { + "val" : "EHDAA2:0000087" + }, { + "val" : "EMAPA:17004" + }, { + "val" : "SCTID:308777005" + }, { + "val" : "TAO:0005008" + }, { + "val" : "Wikipedia:Aortic_arches#Arch_4" + }, { + "val" : "XAO:0000355" + }, { + "val" : "ZFA:0005008" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002185", - "lbl" : "bronchus", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003123", + "lbl" : "pharyngeal arch artery 6", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The vessels formed within the sixth pair of branchial arches in embryogenesis.", + "xrefs" : [ "MP:0006355" ] + }, + "xrefs" : [ { + "val" : "AAO:0010422" + }, { + "val" : "EHDAA2:0000102" + }, { + "val" : "EMAPA:17005" + }, { + "val" : "SCTID:308779008" + }, { + "val" : "TAO:0005016" + }, { + "val" : "VHOG:0000144" + }, { + "val" : "Wikipedia:Aortic_arches#Arch_6" + }, { + "val" : "XAO:0000353" + }, { + "val" : "ZFA:0005016" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002186", - "lbl" : "bronchiole", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002187", - "lbl" : "terminal bronchiole", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003126", + "lbl" : "trachea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph].", + "xrefs" : [ "GO:0060438", "Wikipedia:Vertebrate_trachea" ] + }, + "xrefs" : [ { + "val" : "AAO:0010140" + }, { + "val" : "BTO:0001388" + }, { + "val" : "CALOHA:TS-1060" + }, { + "val" : "EFO:0000935" + }, { + "val" : "EHDAA2:0002066" + }, { + "val" : "EHDAA:3078" + }, { + "val" : "EMAPA:16853" + }, { + "val" : "EV:0100040" + }, { + "val" : "FMA:7394" + }, { + "val" : "GAID:361" + }, { + "val" : "MA:0000441" + }, { + "val" : "MAT:0000137" + }, { + "val" : "MESH:D014132" + }, { + "val" : "MIAA:0000137" + }, { + "val" : "NCIT:C12428" + }, { + "val" : "SCTID:181213009" + }, { + "val" : "VHOG:0000371" + }, { + "val" : "Wikipedia:Vertebrate_trachea" + }, { + "val" : "XAO:0000118" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002188", - "lbl" : "respiratory bronchiole", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003128", + "lbl" : "cranium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Upper portion of the skull that excludes the mandible (when present in the organism).", + "xrefs" : [ "Wikipedia:Cranium_(anatomy)", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001328" + }, { + "val" : "EFO:0000831" + }, { + "val" : "EHDAA:6029" + }, { + "val" : "FMA:71325" + }, { + "val" : "MA:0000316" + }, { + "val" : "MAT:0000340" + }, { + "val" : "MIAA:0000340" + }, { + "val" : "SCTID:181889008" + }, { + "val" : "VHOG:0000334" + }, { + "val" : "Wikipedia:Cranium_(anatomy)" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002190", - "lbl" : "subcutaneous adipose tissue", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003129", + "lbl" : "skull", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP].", + "xrefs" : [ "PMID:11523816", "Wikipedia:Skull", "http://sourceforge.net/tracker/?func=detail&aid=2962656&group_id=76834&atid=1205376" ] + }, + "xrefs" : [ { + "val" : "BTO:0001295" + }, { + "val" : "CALOHA:TS-2344" + }, { + "val" : "EHDAA2:0000325" + }, { + "val" : "EMAPA:17680" + }, { + "val" : "FMA:46565" + }, { + "val" : "GAID:82" + }, { + "val" : "MESH:D012886" + }, { + "val" : "NCIT:C12789" + }, { + "val" : "SCTID:110530005" + }, { + "val" : "Wikipedia:Skull" + }, { + "val" : "WikipediaCategory:Skull" + }, { + "val" : "galen:Skull" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002193", - "lbl" : "hemolymphoid system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002199", - "lbl" : "integument", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003133", + "lbl" : "reproductive organ", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An organ involved in reproduction.", + "xrefs" : [ "UBERON:xp" ] + }, + "xrefs" : [ { + "val" : "MA:0001752" + }, { + "val" : "MESH:D005835" + }, { + "val" : "NCIT:C25177" + }, { + "val" : "SCTID:128181006" + }, { + "val" : "TGMA:0000591" + }, { + "val" : "WBbt:0008422" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002200", - "lbl" : "vasculature of head", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002201", - "lbl" : "vasculature of trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002202", - "lbl" : "submucosa of trachea", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003134", + "lbl" : "female reproductive organ", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A female organ involved in reproduction.", + "xrefs" : [ "UBERON:xp" ] + }, + "xrefs" : [ { + "val" : "EMAPA:28540" + }, { + "val" : "MA:0000544" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002203", - "lbl" : "vasculature of eye", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003215", + "lbl" : "alveolus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Organ part that has the form of a hollow cavity[WP].", + "xrefs" : [ "Wikipedia:Alveolus" ] + }, + "xrefs" : [ { + "val" : "EFO:0002513" + }, { + "val" : "FMA:82493" + }, { + "val" : "NCIT:C12986" + }, { + "val" : "Wikipedia:Alveolus" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002204", - "lbl" : "musculoskeletal system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002213", - "lbl" : "cartilaginous joint", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002217", - "lbl" : "synovial joint", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002224", - "lbl" : "thoracic cavity", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003218", + "lbl" : "ovary septum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO].", + "xrefs" : [ "GO:0080126" ] + } + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002240", - "lbl" : "spinal cord", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003235", + "lbl" : "epithelium of upper jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelium that is part of a upper jaw [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002119" + }, { + "val" : "EHDAA:8027" + }, { + "val" : "EMAPA:18971" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002241", - "lbl" : "chondrocranium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002257", - "lbl" : "ventral horn of spinal cord", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002275", - "lbl" : "reticular formation", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002298", - "lbl" : "brainstem", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002299", - "lbl" : "alveolus of lung", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003236", + "lbl" : "epithelium of lower jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelium that is part of a lower jaw [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001019" + }, { + "val" : "EHDAA:7999" + }, { + "val" : "EMAPA:35516" + }, { + "val" : "VHOG:0000802" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002302", - "lbl" : "myocardium of atrium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002308", - "lbl" : "nucleus of brain", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002315", - "lbl" : "gray matter of spinal cord", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002323", - "lbl" : "coelemic cavity lumen", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002324", - "lbl" : "muscle of back", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003257", + "lbl" : "yolk sac endoderm", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The portion of the yolk sac that is derived from endoderm and lines the yolk sac.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002215" + }, { + "val" : "EHDAA:166" + }, { + "val" : "EMAPA:16086" + }, { + "val" : "VHOG:0000626" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002328", - "lbl" : "notochord", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002329", - "lbl" : "somite", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002330", - "lbl" : "exocrine system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002333", - "lbl" : "pulmonary trunk", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003258", + "lbl" : "endoderm of foregut", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endoderm that is part of a foregut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004568" + }, { + "val" : "EHDAA:524" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002338", - "lbl" : "lamina propria of bronchus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002342", - "lbl" : "neural crest", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002343", - "lbl" : "abdomen musculature", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002345", - "lbl" : "descending thoracic aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003259", + "lbl" : "endoderm of midgut", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endoderm that is part of a midgut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:987" + }, { + "val" : "EMAPA:16257" + }, { + "val" : "RETIRED_EHDAA2:0001194" + }, { + "val" : "VHOG:0001080" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002346", - "lbl" : "neurectoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002348", - "lbl" : "epicardium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003260", + "lbl" : "endoderm of hindgut", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endoderm that is part of a hindgut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:979" + }, { + "val" : "RETIRED_EHDAA2:0000781" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002349", - "lbl" : "myocardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002350", - "lbl" : "conducting system of heart", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002351", - "lbl" : "sinoatrial node", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003269", + "lbl" : "skeletal muscle tissue of eye", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000486" + }, { + "val" : "EHDAA:2923" + }, { + "val" : "EMAPA:17844" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002352", - "lbl" : "atrioventricular node", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "lbl" : "skeleton of upper jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000622" + }, { + "val" : "EHDAA2:0002128" + }, { + "val" : "EHDAA:8041" + }, { + "val" : "EMAPA:17927" + }, { + "val" : "FMA:54397" + }, { + "val" : "MA:0001908" + }, { + "val" : "VHOG:0000429" + }, { + "val" : "XAO:0003087" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002354", - "lbl" : "cardiac Purkinje fiber", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002357", - "lbl" : "serous pericardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002358", - "lbl" : "peritoneum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002359", - "lbl" : "fibrous pericardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002365", - "lbl" : "exocrine gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002368", - "lbl" : "endocrine gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002371", - "lbl" : "bone marrow", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003278", + "lbl" : "skeleton of lower jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000274" + }, { + "val" : "EHDAA2:0004606" + }, { + "val" : "EHDAA:8005" + }, { + "val" : "EMAPA:17910" + }, { + "val" : "FMA:54398" + }, { + "val" : "MA:0001906" + }, { + "val" : "TAO:0001273" + }, { + "val" : "VHOG:0000428" + }, { + "val" : "XAO:0003084" + }, { + "val" : "ZFA:0001273" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002376", - "lbl" : "cranial muscle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003279", + "lbl" : "endothelium of trachea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelium that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:3082" + }, { + "val" : "RETIRED_EHDAA2:0002068" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002377", - "lbl" : "muscle of neck", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003281", + "lbl" : "mesentery of stomach", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/mesogastrium" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001922" + }, { + "val" : "EHDAA:2999" + }, { + "val" : "EMAPA:17024" + }, { + "val" : "MA:0001617" + }, { + "val" : "SCTID:261623000" + }, { + "val" : "VHOG:0000358" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002378", - "lbl" : "muscle of abdomen", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003282", + "lbl" : "mesentery of heart", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mesentery that surrounds the heart.", + "xrefs" : [ "MA:th" ] + }, + "xrefs" : [ { + "val" : "EHDAA:432" + }, { + "val" : "EMAPA:16212" + }, { + "val" : "RETIRED_EHDAA2:0000739" + }, { + "val" : "VHOG:0000353" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002384", - "lbl" : "connective tissue", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003283", + "lbl" : "mesentery of oesophagus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mesentery that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001288" + }, { + "val" : "EHDAA:2943" + }, { + "val" : "EMAPA:16836" + }, { + "val" : "MA:0001569" + }, { + "val" : "VHOG:0000415" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002385", - "lbl" : "muscle tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002390", - "lbl" : "hematopoietic system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003284", + "lbl" : "mesentery of midgut", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mesentery that is part of a midgut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001202" + }, { + "val" : "EHDAA:3031" + }, { + "val" : "EMAPA:16721" + }, { + "val" : "EMAPA:17039" + }, { + "val" : "EMAPA:17197" + }, { + "val" : "VHOG:0000413" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002400", - "lbl" : "parietal pleura", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002401", - "lbl" : "visceral pleura", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003294", + "lbl" : "gland of foregut", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland that is part of a foregut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000567" + }, { + "val" : "EHDAA:950" + }, { + "val" : "EMAPA:16557" + }, { + "val" : "VHOG:0000650" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002402", - "lbl" : "pleural cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002405", - "lbl" : "immune system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003295", + "lbl" : "pharyngeal gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Racemose mucous glands beneath the mucous membrane of the pharynx.", + "xrefs" : [ "http://www.biology-online.org/dictionary/" ] + }, + "xrefs" : [ { + "val" : "BTO:0004849" + }, { + "val" : "EHDAA2:0001461" + }, { + "val" : "EHDAA:2967" + }, { + "val" : "FMA:55075" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002406", - "lbl" : "pericardial sac", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002407", - "lbl" : "pericardium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003297", + "lbl" : "gland of integumental system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland that is part of a integumental system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000837" + }, { + "val" : "EMAPA:17758" + }, { + "val" : "MA:0000144" + }, { + "val" : "VHOG:0000654" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002408", - "lbl" : "parietal serous pericardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002409", - "lbl" : "pericardial fluid", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002410", - "lbl" : "autonomic nervous system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002416", - "lbl" : "integumental system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003304", + "lbl" : "mesoderm blood island", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A blood island that is part of a mesoderm.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0003241" + }, { + "val" : "EHDAA:170" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002417", - "lbl" : "abdominal segment of trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002418", - "lbl" : "cartilage tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002419", - "lbl" : "skin gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002424", - "lbl" : "oral epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002425", - "lbl" : "visceral serous pericardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002443", - "lbl" : "choroidal blood vessel", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002457", - "lbl" : "intersomitic artery", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002458", - "lbl" : "spinal artery", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002469", - "lbl" : "esophagus mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002481", - "lbl" : "bone tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002506", - "lbl" : "iris epithelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003314", + "lbl" : "eye mesenchyme", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Mesenchyme that is part of a developing camera-type eye.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000485" + }, { + "val" : "EHDAA:2910" + }, { + "val" : "EMAPA:16673" + }, { + "val" : "VHOG:0001084" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002513", - "lbl" : "endochondral bone", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002514", - "lbl" : "intramembranous bone", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002521", - "lbl" : "elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002522", - "lbl" : "tunica media", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002523", - "lbl" : "tunica intima", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002530", - "lbl" : "gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002532", - "lbl" : "epiblast (generic)", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002536", - "lbl" : "arthropod sensillum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002539", - "lbl" : "pharyngeal arch", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002546", - "lbl" : "cranial placode", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002553", - "lbl" : "anatomical cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002616", - "lbl" : "regional part of brain", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002726", - "lbl" : "cervical spinal cord", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003315", + "lbl" : "mesenchyme of ovary", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Mesenchyme that is part of a developing ovary [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001362" + }, { + "val" : "EHDAA:8128" + }, { + "val" : "VHOG:0001441" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002925", - "lbl" : "trigeminal nucleus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003023", - "lbl" : "pontine tegmentum", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003316", + "lbl" : "mesenchyme of yolk sac", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002216" + }, { + "val" : "EHDAA:168" + }, { + "val" : "EHDAA:205" + }, { + "val" : "EMAPA:16087" + }, { + "val" : "EMAPA:16267" + }, { + "val" : "VHOG:0000503" + }, { + "val" : "VHOG:0000617" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003037", - "lbl" : "septum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003038", - "lbl" : "thoracic spinal cord", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "lbl" : "mesenchyme of upper jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Mesenchyme that is part of a developing upper jaw [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002124" + }, { + "val" : "EHDAA:8031" + }, { + "val" : "EMAPA:17929" + }, { + "val" : "VHOG:0001099" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003052", - "lbl" : "midbrain-hindbrain boundary", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003055", - "lbl" : "periderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003056", - "lbl" : "pre-chordal neural plate", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003057", - "lbl" : "chordal neural plate", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003059", - "lbl" : "presomitic mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003061", - "lbl" : "blood island", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003063", - "lbl" : "prechordal plate", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003064", - "lbl" : "intermediate mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003067", - "lbl" : "dorsolateral placode", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003068", - "lbl" : "axial mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003070", - "lbl" : "trigeminal placode complex", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003071", - "lbl" : "eye primordium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003072", - "lbl" : "optic cup", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003073", - "lbl" : "lens placode", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003075", - "lbl" : "neural plate", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003076", - "lbl" : "posterior neural tube", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003077", - "lbl" : "paraxial mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003078", - "lbl" : "epibranchial placode", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003080", - "lbl" : "anterior neural tube", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003081", - "lbl" : "lateral plate mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003082", - "lbl" : "myotome", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003083", - "lbl" : "trunk neural crest", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003084", - "lbl" : "heart primordium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003089", - "lbl" : "sclerotome", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003099", - "lbl" : "cranial neural crest", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003100", - "lbl" : "female organism", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003102", - "lbl" : "surface structure", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003103", - "lbl" : "compound organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003104", - "lbl" : "mesenchyme", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003113", - "lbl" : "dermatocranium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003115", - "lbl" : "pharyngeal arch 4", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003117", - "lbl" : "pharyngeal arch 6", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003118", - "lbl" : "pharyngeal arch artery 1", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003121", - "lbl" : "pharyngeal arch artery 4", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003123", - "lbl" : "pharyngeal arch artery 6", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003126", - "lbl" : "trachea", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003324", + "lbl" : "mesenchyme of lower jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Mesenchyme that is part of a developing lower jaw [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001024" + }, { + "val" : "EHDAA:8003" + }, { + "val" : "EMAPA:17916" + }, { + "val" : "VHOG:0001069" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003128", - "lbl" : "cranium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003329", + "lbl" : "submucosa of anal canal", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7762" + "definition" : { + "val" : "A submucosa that is part of an anal canal [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27217" + }, { + "val" : "EMAPA:27227" + }, { + "val" : "EMAPA:27535" + }, { + "val" : "FMA:85399" + }, { + "val" : "SCTID:7892006" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003129", - "lbl" : "skull", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003133", - "lbl" : "reproductive organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003134", - "lbl" : "female reproductive organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003215", - "lbl" : "alveolus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003218", - "lbl" : "ovary septum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003236", - "lbl" : "epithelium of lower jaw", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003257", - "lbl" : "yolk sac endoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003258", - "lbl" : "endoderm of foregut", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003269", - "lbl" : "skeletal muscle tissue of eye", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003278", - "lbl" : "skeleton of lower jaw", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003279", - "lbl" : "endothelium of trachea", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003294", - "lbl" : "gland of foregut", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003295", - "lbl" : "pharyngeal gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003297", - "lbl" : "gland of integumental system", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003330", + "lbl" : "submucosa of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The submucous layer of the wall of the rectum.", + "xrefs" : [ "BTO:0002114" ] + }, + "xrefs" : [ { + "val" : "BTO:0002114" + }, { + "val" : "EMAPA:27083" + }, { + "val" : "FMA:15034" + }, { + "val" : "SCTID:71683001" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003304", - "lbl" : "mesoderm blood island", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003331", + "lbl" : "submucosa of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27379" + }, { + "val" : "FMA:14985" + }, { + "val" : "MA:0003200" + }, { + "val" : "SCTID:61647009" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003314", - "lbl" : "eye mesenchyme", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003332", + "lbl" : "submucosa of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a duodenum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27027" + }, { + "val" : "EMAPA:27097" + }, { + "val" : "EMAPA:27239" + }, { + "val" : "FMA:14943" + }, { + "val" : "MA:0003213" + }, { + "val" : "SCTID:76519004" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003315", - "lbl" : "mesenchyme of ovary", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003334", + "lbl" : "serosa of rectum", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A serous membrane that is part of a rectum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27087" + }, { + "val" : "FMA:15039" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003316", - "lbl" : "mesenchyme of yolk sac", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003335", + "lbl" : "serosa of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27387" + }, { + "val" : "FMA:14990" + }, { + "val" : "MA:0003199" + }, { + "val" : "SCTID:90132000" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003324", - "lbl" : "mesenchyme of lower jaw", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003336", + "lbl" : "serosa of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a duodenum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27247" + }, { + "val" : "FMA:14948" + }, { + "val" : "MA:0003212" + }, { + "val" : "SCTID:1236009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003338", "lbl" : "ganglion of peripheral nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO).", + "xrefs" : [ "BIRNLEX:2548" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:2548" + }, { + "val" : "BTO:0001123" + }, { + "val" : "EMAPA:32814" + }, { + "val" : "MA:0001161" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003339", "lbl" : "ganglion of central nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ganglion that is part of a central nervous system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000227" + }, { + "val" : "EMAPA:16658" + }, { + "val" : "FMA:83843" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003342", + "lbl" : "mucosa of anal canal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of an anal canal [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27531" + }, { + "val" : "FMA:74654" + }, { + "val" : "NCIT:C60784" + }, { + "val" : "SCTID:362170004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003343", "lbl" : "mucosa of oral region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a oral opening [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:362083000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003346", + "lbl" : "mucosa of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a rectum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2107" + }, { + "val" : "EMAPA:27081" + }, { + "val" : "FMA:15033" + }, { + "val" : "MA:0003218" + }, { + "val" : "SCTID:362167003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003350", "lbl" : "epithelium of mucosa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of epithelial cells on the surface of the mucosa.", + "xrefs" : [ "BTO:0003752" ] + }, + "comments" : [ "lies on top of lamina propria" ], + "xrefs" : [ { + "val" : "BTO:0003752" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003351", "lbl" : "pharyngeal epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a pharynx [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BSA:0000112" + }, { + "val" : "BTO:0005240" + }, { + "val" : "EMAPA:16708" + }, { + "val" : "MA:0002725" + }, { + "val" : "RETIRED_EHDAA2:0001460" + }, { + "val" : "TAO:0001174" + }, { + "val" : "XAO:0003202" + }, { + "val" : "ZFA:0001174" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003352", + "lbl" : "epithelium of midgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a midgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0005053" + }, { + "val" : "EHDAA2:0001195" + }, { + "val" : "EMAPA:16569" + }, { + "val" : "MA:0003205" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003353", + "lbl" : "epithelium of hindgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a hindgut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000782" + }, { + "val" : "EMAPA:16717" + }, { + "val" : "MA:0003206" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003354", + "lbl" : "epithelium of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a rectum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2066" + }, { + "val" : "EHDAA2:0001594" + }, { + "val" : "EMAPA:17898" + }, { + "val" : "FMA:17510" + }, { + "val" : "MA:0003219" + }, { + "val" : "VHOG:0001037" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003364", "lbl" : "epithelium of right lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17663" + }, { + "val" : "MA:0003132" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003365", "lbl" : "epithelium of left lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17655" + }, { + "val" : "MA:0003131" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003372", "lbl" : "pectoral appendage bud ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An unilaminar epithelium that surrounds a pectoral appendage bud.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002134" + }, { + "val" : "EMAPA:16407" + }, { + "val" : "VHOG:0001047" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003379", "lbl" : "cardiac muscle of right atrium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004155" + }, { + "val" : "EMAPA:17326" + }, { + "val" : "FMA:7282" + }, { + "val" : "SCTID:362018002" + }, { + "val" : "VHOG:0001227" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003380", "lbl" : "cardiac muscle of left atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004154" + }, { + "val" : "EMAPA:17320" + }, { + "val" : "FMA:7285" + }, { + "val" : "SCTID:189936008" + }, { + "val" : "VHOG:0001225" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003381", "lbl" : "cardiac muscle of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17342" + }, { + "val" : "FMA:83452" + }, { + "val" : "VHOG:0001236" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003382", "lbl" : "cardiac muscle of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17339" + }, { + "val" : "FMA:83453" + }, { + "val" : "VHOG:0001234" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003383", "lbl" : "cardiac muscle tissue of interventricular septum", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004158" + }, { + "val" : "EMAPA:17335" + }, { + "val" : "FMA:84084" + }, { + "val" : "VHOG:0000999" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003384", "lbl" : "skeletal muscle tissue of pharynx", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18963" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003386", "lbl" : "smooth muscle of eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi.", + "xrefs" : [ "MGI:cwg", "MP:0005247" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18807" + }, { + "val" : "MA:0001268" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003387", "lbl" : "smooth muscle of trachea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001391" + }, { + "val" : "EMAPA:19192" + }, { + "val" : "FMA:262010" + }, { + "val" : "MA:0001863" + }, { + "val" : "NCIT:C49306" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003388", "lbl" : "mesothelium of pericardial cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelium that is part of a pericardium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "RETIRED_EHDAA2:0001436" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003389", "lbl" : "mesothelium of diaphragm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelium that is part of a diaphragm [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18429" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003390", "lbl" : "mesothelium of pleural cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelium that is part of a pleural cavity [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0003155" + }, { + "val" : "EHDAA2:0001476" + }, { + "val" : "EMAPA:16775" + }, { + "val" : "FMA:18148" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003393", + "lbl" : "mesentery of urinary system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a urinary system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17367" + }, { + "val" : "MA:0003233" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003394", + "lbl" : "mesentery of hindgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a hindgut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16718" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003395", + "lbl" : "mesentery of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a rectum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18664" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003396", + "lbl" : "mesentery of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18942" + }, { + "val" : "FMA:14645" + }, { + "val" : "SCTID:245457004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003397", + "lbl" : "mesentery of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a duodenum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19081" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003406", "lbl" : "cartilage of respiratory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage element that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18694" + }, { + "val" : "MA:0001818" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003408", "lbl" : "gland of digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a digestive tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18815" + }, { + "val" : "MA:0003202" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003413", "lbl" : "pectoral appendage bud mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a pectoral appendage bud.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002135" + }, { + "val" : "EHDAA:1703" + }, { + "val" : "EMAPA:16408" + }, { + "val" : "TAO:0000789" + }, { + "val" : "ZFA:0000789" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003426", "lbl" : "dermis adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipose tissue that is part of a dermis [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000798" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003429", "lbl" : "abdomen nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of an abdomen [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000521" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003430", "lbl" : "neck nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000588" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003438", "lbl" : "iris nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any nerve that innervates the iris.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35449" + }, { + "val" : "MA:0001291" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003439", "lbl" : "nerve of trunk region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000515" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003443", "lbl" : "thoracic cavity nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is located in a thoracic cavity [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000556" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003452", + "lbl" : "trabecula carnea cardiac muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36573" + }, { + "val" : "FMA:84428" + }, { + "val" : "MA:0002833" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003457", "lbl" : "head bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "Different sources vary regarding which bones are craniofacial; e.g. hyoid bone" ], + "xrefs" : [ { + "val" : "EMAPA:35996" + }, { + "val" : "MA:0000576" + }, { + "val" : "SCTID:118646007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003458", "lbl" : "neck bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000584" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003462", "lbl" : "facial bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a facial skeleton [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19019" + }, { + "val" : "EMAPA:35924" + }, { + "val" : "MA:0001482" + }, { + "val" : "MA:0003159" + }, { + "val" : "NCIT:C63706" + }, { + "val" : "SCTID:181799005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003463", "lbl" : "trunk bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36583" + }, { + "val" : "MA:0000512" + }, { + "val" : "SCTID:427358002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003469", "lbl" : "respiratory system artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001804" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "lbl" : "artery of upper lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose.", + "xrefs" : [ "Wikipedia:Superior_labial_artery" ] + }, + "xrefs" : [ { + "val" : "FMA:49570" + }, { + "val" : "MA:0001917" + }, { + "val" : "SCTID:145137009" + }, { + "val" : "Wikipedia:Superior_labial_artery" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003471", "lbl" : "artery of lower lip", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery.", + "xrefs" : [ "Wikipedia:Inferior_labial_artery" ] + }, + "xrefs" : [ { + "val" : "FMA:49567" + }, { + "val" : "MA:0001916" + }, { + "val" : "SCTID:145036002" + }, { + "val" : "Wikipedia:Inferior_labial_artery" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003473", "lbl" : "thoracic cavity artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that is part of a thoracic cavity[cjm].", + "xrefs" : [ "https://sourceforge.net/tracker/index.php?func=detail&aid=3317815&group_id=76834&atid=1205376" ] + }, + "xrefs" : [ { + "val" : "MA:0001902" + }, { + "val" : "MESH:D013895" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003476", "lbl" : "respiratory system venous blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001809" + }, { + "val" : "MA:0001810" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003477", + "lbl" : "vein of upper lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The inferior labial vein is the vein receiving blood from the upper lip.", + "xrefs" : [ "Wikipedia:Superior_labial_vein" ] + }, + "xrefs" : [ { + "val" : "FMA:52538" + }, { + "val" : "MA:0002255" + }, { + "val" : "SCTID:422755007" + }, { + "val" : "Wikipedia:Superior_labial_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003478", "lbl" : "vein of lower lip", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The inferior labial vein is the vein receiving blood from the lower lip.", + "xrefs" : [ "Wikipedia:Inferior_labial_vein" ] + }, + "xrefs" : [ { + "val" : "FMA:52541" + }, { + "val" : "MA:0002253" + }, { + "val" : "SCTID:422955002" + }, { + "val" : "Wikipedia:Inferior_labial_vein" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003479", "lbl" : "thoracic cavity vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a thoracic cavity [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001903" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003481", + "lbl" : "tail vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a tail [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic", "Wikipedia:Tail_vein" ] + }, + "xrefs" : [ { + "val" : "AAO:0011105" + }, { + "val" : "MA:0002233" + }, { + "val" : "Wikipedia:Tail_vein" + }, { + "val" : "XAO:0000393" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003489", "lbl" : "respiratory system capillary endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium of capillary that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001808" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003494", "lbl" : "respiratory system venule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A venule that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001813" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003495", "lbl" : "respiratory system arteriole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arteriole that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001803" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003496", "lbl" : "head blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36610" + }, { + "val" : "MA:0000575" + }, { + "val" : "SCTID:127865000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003497", "lbl" : "abdomen blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of an abdomen [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000518" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003498", "lbl" : "heart blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a heart [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35397" + }, { + "val" : "MA:0002483" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003499", "lbl" : "brain blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a brain [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35182" + }, { + "val" : "MA:0002769" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003500", "lbl" : "corneal blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a cornea [Automatically generated definition].", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/tracker/index.php?func=detail&aid=3564332&group_id=36855&atid=440764" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36611" + }, { + "val" : "MA:0001241" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003501", "lbl" : "retina blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a retina [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36520" + }, { + "val" : "GAID:509" + }, { + "val" : "MA:0001317" + }, { + "val" : "MESH:D012171" + }, { + "val" : "SCTID:280692003" + }, { + "val" : "XAO:0004153" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003502", "lbl" : "neck blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000583" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003504", "lbl" : "respiratory system blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35731" + }, { + "val" : "EMAPA:35995" + }, { + "val" : "MA:0001799" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003505", "lbl" : "trachea blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35874" + }, { + "val" : "MA:0001852" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003509", "lbl" : "arterial blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "only in MA - supertype of artery, arteriole, aorta." ], + "xrefs" : [ { + "val" : "EMAPA:35144" + }, { + "val" : "MA:0000061" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003511", "lbl" : "iris blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a iris [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001290" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003512", "lbl" : "lung blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32867" + }, { + "val" : "MA:0002457" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003513", "lbl" : "trunk blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000511" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003519", "lbl" : "thoracic cavity blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a thoracic cavity [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000554" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003524", + "lbl" : "tail blood vessel", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a tail [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35848" + }, { + "val" : "MA:0000695" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003526", "lbl" : "respiratory system capillary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001807" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003528", "lbl" : "brain gray matter", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gray matter that is part of a brain [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35184" + }, { + "val" : "MA:0000810" + }, { + "val" : "NCIT:C49333" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003534", + "lbl" : "tail skin", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a tail [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36502" + }, { + "val" : "MA:0000700" + }, { + "val" : "SCTID:67214004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003536", "lbl" : "right lung alveolar duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An alveolar duct that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35819" + }, { + "val" : "MA:0001785" + }, { + "val" : "NCIT:C49277" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003537", "lbl" : "left lung alveolar duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An alveolar duct that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "Mice have 1 left lobe" ], + "xrefs" : [ { + "val" : "EMAPA:19183" + }, { + "val" : "MA:0001776" + }, { + "val" : "NCIT:C49250" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003538", "lbl" : "right lung bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bronchiole that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35425" + }, { + "val" : "MA:0001787" + }, { + "val" : "NCIT:C49279" + }, { + "val" : "SCTID:200089000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003539", "lbl" : "left lung bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bronchiole that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19000" + }, { + "val" : "MA:0001778" + }, { + "val" : "NCIT:C49252" + }, { + "val" : "SCTID:200484003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003540", "lbl" : "right lung terminal bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A terminal bronchiole that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36638" + }, { + "val" : "MA:0001789" + }, { + "val" : "NCIT:C49294" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003541", "lbl" : "left lung terminal bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A terminal bronchiole that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36636" + }, { + "val" : "MA:0001780" + }, { + "val" : "NCIT:C49255" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003542", "lbl" : "right lung respiratory bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A respiratory bronchiole that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36637" + }, { + "val" : "MA:0001788" + }, { + "val" : "NCIT:C49285" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003543", "lbl" : "left lung respiratory bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A respiratory bronchiole that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36635" + }, { + "val" : "MA:0001779" + }, { + "val" : "NCIT:C49254" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003566", "lbl" : "head connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000577" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003567", "lbl" : "abdomen connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of an abdomen [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000519" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003568", "lbl" : "neck connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000585" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003570", "lbl" : "respiratory system connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35968" + }, { + "val" : "EMAPA:35977" + }, { + "val" : "MA:0001814" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003571", "lbl" : "trachea connective tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of connective tissue that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35876" + }, { + "val" : "MA:0001853" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003580", "lbl" : "lower respiratory tract connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002409" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003585", "lbl" : "dermis connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a dermis [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36509" + }, { + "val" : "MA:0000799" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003586", "lbl" : "trunk connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000513" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003592", "lbl" : "bronchus connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32690" + }, { + "val" : "EMAPA:35193" + }, { + "val" : "MA:0001831" + }, { + "val" : "NCIT:C49210" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003593", "lbl" : "thoracic cavity connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000555" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003599", + "lbl" : "tail connective tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a tail [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16749" + }, { + "val" : "MA:0000697" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003601", "lbl" : "neck cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000586" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003603", "lbl" : "lower respiratory tract cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage that is part of a lower respiratory tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001819" + }, { + "val" : "NCIT:C49256" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003604", "lbl" : "trachea cartilage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The ring-shaped cartilaginous structures that support the trachea.", + "xrefs" : [ "J:97123", "MGI:smb", "MP:0003120", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18699" + }, { + "val" : "EMAPA:35875" + }, { + "val" : "FMA:7434" + }, { + "val" : "MA:0001857" + }, { + "val" : "NCIT:C49304" + }, { + "val" : "SCTID:278979006" + }, { + "val" : "Wikipedia:Tracheal_rings" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003605", + "lbl" : "eye skin gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skin gland that is part of a camera-type eye [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002451" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003609", + "lbl" : "aorta elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall.", + "xrefs" : [ "MP:0009862" ] + }, + "xrefs" : [ { + "val" : "MA:0002859" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003610", + "lbl" : "heart elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers.", + "xrefs" : [ "MP:0009863" ] + }, + "xrefs" : [ { + "val" : "MA:0002858" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003611", + "lbl" : "respiratory system elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An elastic tissue that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001820" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003613", + "lbl" : "cardiovascular system elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An elastic tissue that is part of a circulatory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002857" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003614", + "lbl" : "blood vessel elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Elastic tissue layer that lines a blood vessel layer.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/p/obo/mammalian-phenotype-requests/2026/" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36300" + }, { + "val" : "MA:0002856" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003615", + "lbl" : "lung elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Elastic tissue that is part of a lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002860" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003616", + "lbl" : "bronchus elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An elastic tissue that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001838" + }, { + "val" : "NCIT:C49211" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003617", + "lbl" : "trachea elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An elastic tissue that is part of a trachea [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001861" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003618", + "lbl" : "aorta tunica media", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers.", + "xrefs" : [ "MP:0009873" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35138" + }, { + "val" : "FMA:74433" + }, { + "val" : "MA:0002903" + }, { + "val" : "SCTID:48467007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003619", + "lbl" : "aorta tunica intima", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The innermost layer of the aorta, containing the endothelium and an inner elastic membrane.", + "xrefs" : [ "MP:0009872" ] + }, + "xrefs" : [ { + "val" : "BTO:0005553" + }, { + "val" : "EMAPA:35137" + }, { + "val" : "FMA:74419" + }, { + "val" : "MA:0002904" + }, { + "val" : "SCTID:362031007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003643", + "lbl" : "respiratory system arterial blood vessel", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arterial blood vessel that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001800" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003665", + "lbl" : "post-anal tail muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle organ that attaches to a tail vertebra [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000081" + }, { + "val" : "BTO:0001905" + }, { + "val" : "MA:0000699" + }, { + "val" : "SCTID:113230005" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003684", + "lbl" : "abdominal cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity).", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "EFO:0000213" + }, { + "val" : "EMAPA:36505" + }, { + "val" : "FMA:12266" + }, { + "val" : "GAID:17" + }, { + "val" : "MA:0003057" + }, { + "val" : "MESH:D034841" + }, { + "val" : "NCIT:C12664" + }, { + "val" : "SCTID:361294009" + }, { + "val" : "Wikipedia:Abdominal_cavity" + }, { + "val" : "galen:AbdominalCavity" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003687", + "lbl" : "foramen magnum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Foramen_magnum" ] + }, + "comments" : [ "Design pattern notes: check whether this fits the foramen design pattern" ], + "xrefs" : [ { + "val" : "AAO:0010826" + }, { + "val" : "FMA:75306" + }, { + "val" : "GAID:228" + }, { + "val" : "MESH:D005539" + }, { + "val" : "NCIT:C12495" + }, { + "val" : "SCTID:244679008" + }, { + "val" : "TAO:0002045" + }, { + "val" : "Wikipedia:Foramen_magnum" + }, { + "val" : "ZFA:0005387" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "lbl" : "atlanto-axial joint", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas.", + "xrefs" : [ "Wikipedia:Atlanto-axial_joint" ] + }, + "xrefs" : [ { + "val" : "FMA:25524" + }, { + "val" : "GAID:250" + }, { + "val" : "MESH:D001268" + }, { + "val" : "NCIT:C32157" + }, { + "val" : "SCTID:361832004" + }, { + "val" : "Wikipedia:Atlanto-axial_joint" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003697", + "lbl" : "abdominal wall", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles.", + "xrefs" : [ "ncithesaurus:Abdominal_Wall" ] + }, + "xrefs" : [ { + "val" : "FMA:10429" + }, { + "val" : "FMA:259054" + }, { + "val" : "GAID:26" + }, { + "val" : "MESH:D034861" + }, { + "val" : "NCIT:C77608" + }, { + "val" : "SCTID:181613000" + }, { + "val" : "Wikipedia:Abdominal_wall" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003605", - "lbl" : "eye skin gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003609", - "lbl" : "aorta elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003610", - "lbl" : "heart elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003611", - "lbl" : "respiratory system elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003613", - "lbl" : "cardiovascular system elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003614", - "lbl" : "blood vessel elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003615", - "lbl" : "lung elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003616", - "lbl" : "bronchus elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003617", - "lbl" : "trachea elastic tissue", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003703", + "lbl" : "extrahepatic bile duct", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct.", + "xrefs" : [ "MESH:A03.159.183.079" ] + }, + "xrefs" : [ { + "val" : "FMA:14678" + }, { + "val" : "GAID:281" + }, { + "val" : "MA:0002659" + }, { + "val" : "MESH:D017734" + }, { + "val" : "NCIT:C32573" + }, { + "val" : "SCTID:276158002" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003618", - "lbl" : "aorta tunica media", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003619", - "lbl" : "aorta tunica intima", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003643", - "lbl" : "respiratory system arterial blood vessel", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003684", - "lbl" : "abdominal cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003687", - "lbl" : "foramen magnum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003697", - "lbl" : "abdominal wall", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003704", + "lbl" : "intrahepatic bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.", + "xrefs" : [ "MESH:A03.159.183.158" ] + }, + "xrefs" : [ { + "val" : "FMA:15766" + }, { + "val" : "GAID:287" + }, { + "val" : "MA:0001630" + }, { + "val" : "MESH:D001653" + }, { + "val" : "NCIT:C12677" + }, { + "val" : "SCTID:362193005" + }, { + "val" : "TAO:0005169" + }, { + "val" : "ZFA:0005169" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003711", "lbl" : "brachiocephalic vein", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava.", + "xrefs" : [ "Wikipedia:Brachiocephalic_vein" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000182" + }, { + "val" : "EHDAA:9868" + }, { + "val" : "FMA:4723" + }, { + "val" : "GAID:529" + }, { + "val" : "MESH:D016121" + }, { + "val" : "NCIT:C32816" + }, { + "val" : "SCTID:181371003" + }, { + "val" : "Wikipedia:Brachiocephalic_vein" + }, { + "val" : "galen:BrachiocephalicVein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003713", + "lbl" : "splenic vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein.", + "xrefs" : [ "ncithesaurus:Splenic_Vein" ] + }, + "xrefs" : [ { + "val" : "FMA:14331" + }, { + "val" : "GAID:541" + }, { + "val" : "MA:0002164" + }, { + "val" : "MESH:D013162" + }, { + "val" : "NCIT:C33608" + }, { + "val" : "SCTID:278029005" + }, { + "val" : "Wikipedia:Splenic_vein" + }, { + "val" : "galen:SplenicVein" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003714", "lbl" : "neural tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature.", + "xrefs" : [ "FMA:9642" ] + }, + "xrefs" : [ { + "val" : "AAO:0000325" + }, { + "val" : "AEO:0000123" + }, { + "val" : "EHDAA2:0003123" + }, { + "val" : "FMA:9642" + }, { + "val" : "GAID:609" + }, { + "val" : "MESH:D009417" + }, { + "val" : "NCIT:C13052" + }, { + "val" : "SCTID:91728009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003715", "lbl" : "splanchnic nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia.", + "xrefs" : [ "MP:0008318" ] + }, + "xrefs" : [ { + "val" : "BAMS:spn" + }, { + "val" : "FMA:5883" + }, { + "val" : "GAID:800" + }, { + "val" : "MESH:D013153" + }, { + "val" : "SCTID:264198001" + }, { + "val" : "Wikipedia:Splanchnic_nerves" } ] } }, { @@ -19550,381 +66246,1845 @@ "lbl" : "thoracic nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls.", + "xrefs" : [ "MESH:A08.800.800.720.800" ] + }, + "xrefs" : [ { + "val" : "FMA:5860" + }, { + "val" : "GAID:857" + }, { + "val" : "MESH:D013900" + }, { + "val" : "SCTID:360498003" + }, { + "val" : "Wikipedia:Thoracic_nerves" + }, { + "val" : "neuronames:1725" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003727", "lbl" : "intercostal nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Intercostal_nerves" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18227" + }, { + "val" : "FMA:6028" + }, { + "val" : "GAID:858" + }, { + "val" : "MESH:D007367" + }, { + "val" : "NCIT:C32825" + }, { + "val" : "SCTID:279568001" + }, { + "val" : "Wikipedia:Intercostal_nerves" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003729", "lbl" : "mouth mucosa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucous membrane that lines the mouth.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0002860" + }, { + "val" : "CALOHA:TS-0716" + }, { + "val" : "EMAPA:26937" + }, { + "val" : "FMA:59660" + }, { + "val" : "GAID:951" + }, { + "val" : "MA:0002794" + }, { + "val" : "MESH:D009061" + }, { + "val" : "NCIT:C77637" + }, { + "val" : "Wikipedia:Oral_mucosa" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003824", "lbl" : "nerve of thoracic segment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000562" + }, { + "val" : "MESH:D013900" + }, { + "val" : "SCTID:359876006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003825", "lbl" : "nerve of abdominal segment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000528" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003827", "lbl" : "thoracic segment bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000559" + }, { + "val" : "SCTID:426649006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003828", "lbl" : "abdominal segment bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000525" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003830", "lbl" : "thoracic segment muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000561" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003831", "lbl" : "respiratory system muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35733" + }, { + "val" : "MA:0001828" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003832", "lbl" : "esophagus muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26983" + }, { + "val" : "MA:0002682" + }, { + "val" : "SCTID:360961009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003833", "lbl" : "abdominal segment muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000527" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003834", "lbl" : "thoracic segment blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000558" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003835", "lbl" : "abdominal segment blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000524" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003836", "lbl" : "abdominal segment skin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skin of body that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:264898" + }, { + "val" : "MA:0000530" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003837", "lbl" : "thoracic segment connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000560" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003838", "lbl" : "abdominal segment connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000526" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003842", "lbl" : "neural tube lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that surrounded_by a neural tube.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0011073" + }, { + "val" : "EHDAA2:0001269" + }, { + "val" : "EHDAA:2889" + }, { + "val" : "EHDAA:914" + }, { + "val" : "EMAPA:16167" + }, { + "val" : "VHOG:0001119" + }, { + "val" : "XAO:0000252" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003848", "lbl" : "gonadal vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted].", + "xrefs" : [ "Wikipedia:Gonadal_vein" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000719" + }, { + "val" : "EHDAA:8703" + }, { + "val" : "SCTID:278192008" + }, { + "val" : "VHOG:0001340" + }, { + "val" : "Wikipedia:Gonadal_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003849", "lbl" : "mesencephalic neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural crest that has_potential_to_developmentally_contribute_to a midbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003591" + }, { + "val" : "EHDAA2:0001101" + }, { + "val" : "EHDAA:360" + }, { + "val" : "TAO:0000935" + }, { + "val" : "VHOG:0000796" + }, { + "val" : "ZFA:0000935" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003852", "lbl" : "rhombencephalon neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001628" + }, { + "val" : "EHDAA:362" + }, { + "val" : "EMAPA:35747" + }, { + "val" : "TAO:0007063" + }, { + "val" : "VHOG:0001210" + }, { + "val" : "ZFA:0007063" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003853", "lbl" : "spinal cord neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural crest that has_potential_to_developmentally_contribute_to a spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:696" + }, { + "val" : "EMAPA:16163" + }, { + "val" : "EMAPA:16881" + }, { + "val" : "VHOG:0001006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003854", "lbl" : "spinal cord neural plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural plate that develops_from a future spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:312957" + }, { + "val" : "TAO:0007021" + }, { + "val" : "VHOG:0000439" + }, { + "val" : "ZFA:0007021" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003855", "lbl" : "gonad mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing gonad [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:5012" + }, { + "val" : "EMAPA:16858" + }, { + "val" : "EMAPA:17385" + }, { + "val" : "VHOG:0001090" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003869", "lbl" : "presumptive ganglion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A presumptive structure that has the potential to develop into a ganglion.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003886", "lbl" : "future coelemic cavity lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that has the potential to develop into a coelemic cavity lumen.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003887", "lbl" : "intraembryonic coelom", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.", + "xrefs" : [ "MGI:anna", "MP:0012187" ] + }, + "xrefs" : [ { + "val" : "EHDAA:251" + }, { + "val" : "EMAPA:16088" + }, { + "val" : "NCIT:C34195" + }, { + "val" : "VHOG:0000316" + }, { + "val" : "Wikipedia:Intraembryonic_coelom" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003891", "lbl" : "stroma", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:81494" + }, { + "val" : "NCIT:C67387" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "lbl" : "liver primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum.", + "xrefs" : [ "ISBN:3211492755" ] + }, + "xrefs" : [ { + "val" : "AAO:0011058" + }, { + "val" : "BTO:0003391" + }, { + "val" : "EFO:0002577" + }, { + "val" : "EFO:0003428" + }, { + "val" : "EHDAA2:0000744" + }, { + "val" : "EHDAA:973" + }, { + "val" : "EMAPA:16847" + }, { + "val" : "NCIT:C34277" + }, { + "val" : "TAO:0000124" + }, { + "val" : "XAO:0003266" + }, { + "val" : "ZFA:0000124" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003898", "lbl" : "skeletal muscle tissue of trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue in the trunk.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "SCTID:244848007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003902", "lbl" : "retinal neural layer", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the retina that contains neurons and photoreceptor cells[GO].", + "xrefs" : [ "GO:0003407" ] + }, + "xrefs" : [ { + "val" : "AAO:0011095" + }, { + "val" : "BTO:0000929" + }, { + "val" : "CALOHA:TS-0685" + }, { + "val" : "EHDAA2:0001253" + }, { + "val" : "EHDAA:4763" + }, { + "val" : "EMAPA:17171" + }, { + "val" : "EMAPA:18590" + }, { + "val" : "FMA:58628" + }, { + "val" : "MA:0000277" + }, { + "val" : "NCIT:C33166" + }, { + "val" : "TAO:0000046" + }, { + "val" : "VHOG:0000535" + }, { + "val" : "XAO:0003216" + }, { + "val" : "ZFA:0000046" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003909", "lbl" : "sinusoid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP].", + "xrefs" : [ "Wikipedia:Sinusoid_(blood_vessel)" ] + }, + "xrefs" : [ { + "val" : "FMA:63131" + }, { + "val" : "SCTID:340163004" + }, { + "val" : "TAO:0005261" + }, { + "val" : "Wikipedia:Sinusoid_(blood_vessel)" + }, { + "val" : "ZFA:0005261" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003914", "lbl" : "epithelial tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.", + "xrefs" : [ "GO:0060562", "PMID:12526790" ] + }, + "xrefs" : [ { + "val" : "AEO:0000114" + }, { + "val" : "EHDAA2:0003114" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003915", "lbl" : "endothelial tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any endothelium that has the quality of being cylindrical [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003920", "lbl" : "venous blood vessel", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A blood vessel that carries blood from the capillaries toward the heart.", + "xrefs" : [ "http://www.thefreedictionary.com/venous+blood+vessel" ] + }, + "comments" : [ "Compare to: vein" ], + "xrefs" : [ { + "val" : "EMAPA:35932" + }, { + "val" : "FMA:86188" + }, { + "val" : "MA:0000066" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "lbl" : "pancreas primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Embryonic structure that develops into pancreatic bud.", + "xrefs" : [ "Wikipedia:Pancreas#Embryological_development" ] + }, + "xrefs" : [ { + "val" : "EFO:0002579" + }, { + "val" : "EFO:0003434" + }, { + "val" : "EHDAA2:0001382" + }, { + "val" : "EHDAA:2163" + }, { + "val" : "EMAPA:17066" + }, { + "val" : "FMA:79792" + }, { + "val" : "TAO:0000254" + }, { + "val" : "XAO:0001101" + }, { + "val" : "ZFA:0000254" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "lbl" : "pancreatic epithelial bud", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID].", + "xrefs" : [ "PMID:16417468", "Wikipedia:Pancreatic_bud" ] + }, + "xrefs" : [ { + "val" : "EFO:0003470" + }, { + "val" : "EMAPA:35645" + }, { + "val" : "NCIT:C34242" + }, { + "val" : "SCTID:360398004" + }, { + "val" : "TAO:0001390" + }, { + "val" : "Wikipedia:Pancreatic_bud" + }, { + "val" : "ZFA:0001390" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003923", + "lbl" : "dorsal pancreatic bud", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Pancreatic bud that gives rise to the accessory pancreatic duct.", + "xrefs" : [ "Wikipedia:Pancreatic_bud" ] + }, + "xrefs" : [ { + "val" : "AAO:0011031" + }, { + "val" : "EFO:0003465" + }, { + "val" : "EHDAA2:0001385" + }, { + "val" : "EMAPA:17067" + }, { + "val" : "SCTID:361435005" + }, { + "val" : "TAO:0001370" + }, { + "val" : "VHOG:0001428" + }, { + "val" : "Wikipedia:Pancreatic_bud" + }, { + "val" : "XAO:0000467" + }, { + "val" : "ZFA:0001370" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003924", + "lbl" : "ventral pancreatic bud", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Pancreatic bud that gives rise to the major pancreatic duct.", + "xrefs" : [ "Wikipedia:Pancreatic_bud" ] + }, + "xrefs" : [ { + "val" : "AAO:0011111" + }, { + "val" : "EFO:0003464" + }, { + "val" : "EHDAA2:0001389" + }, { + "val" : "EMAPA:17256" + }, { + "val" : "SCTID:361437002" + }, { + "val" : "TAO:0001369" + }, { + "val" : "VHOG:0001429" + }, { + "val" : "Wikipedia:Pancreatic_bud" + }, { + "val" : "XAO:0001103" + }, { + "val" : "ZFA:0001369" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003928", "lbl" : "digestive system duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A duct that is part of a digestive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005162" + }, { + "val" : "ZFA:0005162" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003929", "lbl" : "digestive tract epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that lines the lumen of the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000956" + }, { + "val" : "EHDAA2:0004567" + }, { + "val" : "EMAPA:32928" + }, { + "val" : "MA:0003201" + }, { + "val" : "NCIT:C12963" + }, { + "val" : "TAO:0005123" + }, { + "val" : "XAO:0003200" + }, { + "val" : "ZFA:0005123" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003932", "lbl" : "cartilage element of chondrocranium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage element of chondrocranium. Example: neurocranial trabecula.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EFO:0003690" + }, { + "val" : "TAO:0001461" + }, { + "val" : "ZFA:0001461" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003933", "lbl" : "cranial cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage element that is part of the cranial skeleton.", + "xrefs" : [ "ZFA:0001458", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001458" + }, { + "val" : "ZFA:0001458" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003937", "lbl" : "reproductive gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction.", + "xrefs" : [ "MP:0000653" ] + }, + "xrefs" : [ { + "val" : "MA:0001751" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003942", "lbl" : "somatosensory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sensory system for the sense of touch and pain.", + "xrefs" : [ "NLXANAT:090818" ] + }, + "xrefs" : [ { + "val" : "NLXANAT:090818" + }, { + "val" : "Wikipedia:Somatosensory_system" + }, { + "val" : "neuronames:2887" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003952", "lbl" : "anterior stroma of cornea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "The anterior segment of the lamellated connective tissue layer of the cornea.", + "xrefs" : [ "MP:0003093" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003953", "lbl" : "posterior stroma of cornea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The posterior segment of the lamellated connective tissue layer of the cornea.", + "xrefs" : [ "MP:0003094" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003967", "lbl" : "cutaneous elastic tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity.", + "xrefs" : [ "MP:0008418" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003975", "lbl" : "internal female genitalia", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina.", + "xrefs" : [ "MP:0009209" ] + }, + "comments" : [ "TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547" ], + "xrefs" : [ { + "val" : "BTO:0003099" + }, { + "val" : "FMA:45654" + }, { + "val" : "SCTID:303518005" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004015", "lbl" : "embryonic-extraembryonic boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connection between the embryo proper and extraembryonic tissues.", + "xrefs" : [ "MP:0003890" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004016", "lbl" : "dermatome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells.", + "xrefs" : [ "AEO:0001017", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AAO:0011028" + }, { + "val" : "AEO:0001017" + }, { + "val" : "EHDAA2_RETIRED:0003428" + }, { + "val" : "EHDAA:1719" + }, { + "val" : "EHDAA:1725" + }, { + "val" : "EHDAA:1731" + }, { + "val" : "EHDAA:1737" + }, { + "val" : "EMAPA:32838" + }, { + "val" : "FMA:295656" + }, { + "val" : "NCIT:C61572" + }, { + "val" : "Wikipedia:Dermatome_(embryology)" + }, { + "val" : "XAO:0000220" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004022", "lbl" : "germinal neuroepithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells.", + "xrefs" : [ "MP:0004261", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "lbl" : "biliary ductule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP].", + "xrefs" : [ "BTO:0002840", "MP:0009494" ] + }, + "xrefs" : [ { + "val" : "BTO:0002840" + }, { + "val" : "TAO:0005164" + }, { + "val" : "ZFA:0005164" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004060", "lbl" : "neural tube ventricular layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium.", + "xrefs" : [ "MP:0009689", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17152" + }, { + "val" : "EMAPA:35362" + }, { + "val" : "EMAPA_RETIRED:16783" + }, { + "val" : "MA:0003193" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004061", "lbl" : "neural tube mantle layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer.", + "xrefs" : [ "MP:0009690", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17148" + }, { + "val" : "EMAPA:35360" + }, { + "val" : "neuronames:1367" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004062", "lbl" : "neural tube marginal layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter.", + "xrefs" : [ "MP:0009691", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17151" + }, { + "val" : "neuronames:1368" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004064", "lbl" : "neural tube basal plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons.", + "xrefs" : [ "MP:0009693", "Wikipedia:Basal_plate_(neural_tube)", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + }, + "xrefs" : [ { + "val" : "AAO:0010561" + }, { + "val" : "EFO:0001904" + }, { + "val" : "NCIT:C34111" + }, { + "val" : "Wikipedia:Basal_plate_(neural_tube)" + }, { + "val" : "neuronames:1372" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004066", + "lbl" : "frontonasal prominence", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout.", + "xrefs" : [ "MP:0009901" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000578" + }, { + "val" : "EHDAA:4778" + }, { + "val" : "EMAPA:16681" + }, { + "val" : "FMA:293101" + }, { + "val" : "NCIT:C34182" + }, { + "val" : "SCTID:361486000" + }, { + "val" : "VHOG:0001319" + }, { + "val" : "Wikipedia:Frontonasal_prominence" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004068", + "lbl" : "medial nasal prominence", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it.", + "xrefs" : [ "MP:0009903", "Wikipedia:Medial_nasal_prominence" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001076" + }, { + "val" : "EHDAA:4792" + }, { + "val" : "EMAPA:16808" + }, { + "val" : "FMA:295858" + }, { + "val" : "SCTID:308877001" + }, { + "val" : "VHOG:0000804" + }, { + "val" : "Wikipedia:Medial_nasal_prominence" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004087", "lbl" : "vena cava", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart.", + "xrefs" : [ "Wikipedia:Venae_cavae", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010215" + }, { + "val" : "BTO:0001438" + }, { + "val" : "EMAPA:18415" + }, { + "val" : "FMA:321896" + }, { + "val" : "GAID:547" + }, { + "val" : "MA:0000068" + }, { + "val" : "MESH:D014684" + }, { + "val" : "NCIT:C12817" + }, { + "val" : "SCTID:244405007" + }, { + "val" : "Wikipedia:Venae_cavae" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004088", "lbl" : "orbital region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:260119" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004089", + "lbl" : "midface", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The middle of the face including the nose and its associated bony structures[MW].", + "xrefs" : [ "HP:0000309", "http://www.merriam-webster.com/medical/midface" ] + }, + "xrefs" : [ { + "val" : "FMA:285406" + }, { + "val" : "MA:0001910" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004111", "lbl" : "anatomical conduit", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Any tube, opening or passage that connects two distinct anatomical spaces.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0000080" + }, { + "val" : "EHDAA2:0003080" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:242873" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "SCTID:346902003" + }, { + "val" : "Wikipedia:Foramen" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004118", "lbl" : "vasculature of iris", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a iris [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "ZFA:0005568" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004119", "lbl" : "endoderm-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops (entirely or partially) from the endoderm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004120", "lbl" : "mesoderm-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops (entirely or partially) from the mesoderm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004121", "lbl" : "ectoderm-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops (entirely or partially) from the ectoderm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "lbl" : "genitourinary system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction.", + "xrefs" : [ "VHOG:0000286" ] + }, + "xrefs" : [ { + "val" : "AAO:0000624" + }, { + "val" : "BILA:0000122" + }, { + "val" : "BTO:0003091" + }, { + "val" : "EFO:0003864" + }, { + "val" : "EHDAA:1013" + }, { + "val" : "EMAPA:16367" + }, { + "val" : "EV:0100094" + }, { + "val" : "FMA:280610" + }, { + "val" : "GAID:362" + }, { + "val" : "MESH:D014566" + }, { + "val" : "NCIT:C12810" + }, { + "val" : "SCTID:278861008" + }, { + "val" : "VHOG:0000286" + }, { + "val" : "XAO:0000140" + }, { + "val" : "galen:GenitoUrinarySystem" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004123", + "lbl" : "myocardial layer", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the layers of the myocardium. Example: compact layer, trabecular layer.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000080" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004124", + "lbl" : "myocardium trabecular layer", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA].", + "xrefs" : [ "ZFA:0005059" ] + }, + "xrefs" : [ { + "val" : "EFO:0003706" + }, { + "val" : "MA:0002866" + }, { + "val" : "TAO:0005059" + }, { + "val" : "ZFA:0005059" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004126", + "lbl" : "trabecular layer of ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myocardium trabecular layer that is part of a cardiac ventricle.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:83511" + }, { + "val" : "TAO:0005060" + }, { + "val" : "ZFA:0005060" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004128", "lbl" : "optic vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA].", + "xrefs" : [ "GO:0003404", "Wikipedia:Optic_vesicles" ] + }, + "comments" : [ "Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 \"Developmental Biology\"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288]" ], + "xrefs" : [ { + "val" : "AAO:0011039" + }, { + "val" : "EHDAA2:0001320" + }, { + "val" : "EMAPA:16540" + }, { + "val" : "FMA:293357" + }, { + "val" : "NCIT:C34236" + }, { + "val" : "SCTID:362864008" + }, { + "val" : "TAO:0000050" + }, { + "val" : "VHOG:0000165" + }, { + "val" : "Wikipedia:Optic_vesicles" + }, { + "val" : "XAO:0000228" + }, { + "val" : "ZFA:0000050" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004133", "lbl" : "salivatory nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Missing definition for term UBERON:0004133. Please replace it using linked reference.", + "xrefs" : [ "GO:0021751" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004139", "lbl" : "cardiogenic plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first recognizable structure derived from the heart field.", + "xrefs" : [ "GO:0003142" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000215" + }, { + "val" : "EMAPA:16106" + }, { + "val" : "VHOG:0000975" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004140", "lbl" : "primary heart field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.", + "xrefs" : [ "GO:0003138", "GOC:mtg_heart", "GOC:rl" ] + }, + "xrefs" : [ { + "val" : "XAO:0004185" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004141", "lbl" : "heart tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial tube that will give rise to the mature heart.", + "xrefs" : [ "GO:0003143", "GOC:mtg_heart" ] + }, + "xrefs" : [ { + "val" : "AAO:0010411" + }, { + "val" : "EFO:0003526" + }, { + "val" : "EMAPA:32685" + }, { + "val" : "NCIT:C34161" + }, { + "val" : "TAO:0000360" + }, { + "val" : "XAO:0000337" + }, { + "val" : "ZFA:0000360" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004142", "lbl" : "outflow tract septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outflow tract septum is a partition in the outflow tract.", + "xrefs" : [ "GO:0003148" ] + }, + "xrefs" : [ { + "val" : "XAO:0004141" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004145", "lbl" : "outflow tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outflow tract is the portion of the heart through which blood flows into the arteries.", + "xrefs" : [ "GO:0003151" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001351" + }, { + "val" : "EHDAA:464" + }, { + "val" : "EHDAA:798" + }, { + "val" : "EMAPA:16346" + }, { + "val" : "MA:0000100" + }, { + "val" : "VHOG:0000670" + }, { + "val" : "XAO:0004139" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004146", "lbl" : "His-Purkinje system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.", + "xrefs" : [ "GO:0003164", "https://github.com/geneontology/go-ontology/issues/12451" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004148", "lbl" : "cardiac vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vein of heart that drains the myocardium.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004507" + }, { + "val" : "FMA:12846" + }, { + "val" : "NCIT:C12878" + }, { + "val" : "NCIT:C12882" + }, { + "val" : "SCTID:277726009" + }, { + "val" : "Wikipedia:Coronary_circulation" + }, { + "val" : "ZFA:0005814" + }, { + "val" : "galen:CoronaryVein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004151", "lbl" : "cardiac chamber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac chamber surrounds an enclosed cavity within the heart.", + "xrefs" : [ "GO:0003205" ] + }, + "comments" : [ "generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus" ], + "xrefs" : [ { + "val" : "FMA:7095" + }, { + "val" : "SCTID:276456008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004160", "lbl" : "proepicardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium.", + "xrefs" : [ "GO:0003342", "http://en.wiktionary.org/wiki/proepicardium" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36025" + }, { + "val" : "ZFA:0005808" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004161", "lbl" : "septum transversum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG].", + "xrefs" : [ "VHOG:0000019", "Wikipedia:Septum_transversum" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001829" + }, { + "val" : "EHDAA:736" + }, { + "val" : "EMAPA:16318" + }, { + "val" : "FMA:295593" + }, { + "val" : "NCIT:C34296" + }, { + "val" : "SCTID:308819008" + }, { + "val" : "VHOG:0000019" + }, { + "val" : "Wikipedia:Septum_transversum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004175", "lbl" : "internal genitalia", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.", + "xrefs" : [ "GO:0035260" ] + }, + "comments" : [ "TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547" ], + "xrefs" : [ { + "val" : "FMA:45652" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004176", "lbl" : "external genitalia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The external genitalia are the outer sex organs, such as the penis or vulva in mammals.", + "xrefs" : [ "GO:0035261" ] + }, + "comments" : [ "TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547" ], + "xrefs" : [ { + "val" : "FMA:45643" + }, { + "val" : "SCTID:362207005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004177", "lbl" : "hemopoietic organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ that is part of the hematopoietic system.", + "xrefs" : [ "GOC:Obol" ] + }, + "xrefs" : [ { + "val" : "BTO:0004605" + }, { + "val" : "FMA:7143" + }, { + "val" : "MA:0000747" + }, { + "val" : "SCTID:361338006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004178", "lbl" : "aorta smooth muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The nonstriated, involuntary muscle tissue located in the wall of the aorta.", + "xrefs" : [ "MGI:csmith", "MP:0009865" ] + }, + "xrefs" : [ { + "val" : "BTO:0001685" + }, { + "val" : "CALOHA:TS-0048" + }, { + "val" : "EFO:0002775" + }, { + "val" : "EMAPA:35135" + }, { + "val" : "MA:0000702" + }, { + "val" : "NCIT:C49191" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004185", "lbl" : "endodermal part of digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portions of the gut that is derived from endoderm.", + "xrefs" : [ "GO:0061031" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32930" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004215", "lbl" : "back nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000497" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004220", + "lbl" : "large intestine smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35469" + }, { + "val" : "MA:0001547" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "lbl" : "intestine smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000643" + }, { + "val" : "EMAPA:35441" + }, { + "val" : "EMAPA:35443" + }, { + "val" : "MA:0001539" + }, { + "val" : "NCIT:C49243" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004222", "lbl" : "stomach smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001818" + }, { + "val" : "EMAPA:35823" + }, { + "val" : "MA:0001627" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004225", "lbl" : "respiratory system smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001660" + }, { + "val" : "EMAPA:35734" + }, { + "val" : "MA:0001830" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004226", "lbl" : "gastrointestinal system smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35117" + }, { + "val" : "MA:0001523" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004231", + "lbl" : "anal region smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001532" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004233", "lbl" : "lower respiratory tract smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35520" + }, { + "val" : "MA:0002410" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004234", "lbl" : "iris smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a iris [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000655" + }, { + "val" : "EMAPA:35448" + }, { + "val" : "FMA:312338" + }, { + "val" : "MA:0001270" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004236", "lbl" : "arteriole smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36287" + }, { + "val" : "FMA:312251" + }, { + "val" : "MA:0000706" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004237", "lbl" : "blood vessel smooth muscle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Smooth muscle found within, and composing the majority of the wall of blood vessels.", + "xrefs" : [ "Wikipedia:Vascular_smooth_muscle" ] + }, + "xrefs" : [ { + "val" : "BTO:0001431" + }, { + "val" : "CALOHA:TS-1107" + }, { + "val" : "EMAPA:35177" + }, { + "val" : "MA:0000710" + }, { + "val" : "MESH:D009131" + }, { + "val" : "NCIT:C33853" + }, { + "val" : "TAO:0005321" + }, { + "val" : "Wikipedia:Vascular_smooth_muscle" + }, { + "val" : "ZFA:0005321" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004238", + "lbl" : "spleen smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35807" + }, { + "val" : "MA:0000757" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004239", + "lbl" : "small intestine smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35783" + }, { + "val" : "MA:0001559" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004240", + "lbl" : "gallbladder smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35373" + }, { + "val" : "MA:0001635" + }, { + "val" : "NCIT:C49483" } ] } }, { @@ -19932,181 +68092,756 @@ "lbl" : "bronchus smooth muscle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004401" + }, { + "val" : "EMAPA:35195" + }, { + "val" : "MA:0001840" + }, { + "val" : "NCIT:C49213" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004246", "lbl" : "outflow tract smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000492" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004247", "lbl" : "bone of dorsum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of the dorsal region of an animal.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000494" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004253", "lbl" : "skin muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a skin of body [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18187" + }, { + "val" : "EMAPA:35776" + }, { + "val" : "MA:0002710" + }, { + "val" : "MA:0003139" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004258", "lbl" : "back blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000493" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004265", "lbl" : "outflow tract myocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myocardium that is part of a outflow tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001358" + }, { + "val" : "EMAPA:35623" + }, { + "val" : "MA:0000489" + }, { + "val" : "VHOG:0000603" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004267", "lbl" : "back connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000495" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004271", "lbl" : "outflow tract pericardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pericardium that is part of a outflow tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000491" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004277", "lbl" : "eye muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle that is part of the eye region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000156" + }, { + "val" : "EMAPA:35335" + }, { + "val" : "MA:0000271" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004288", "lbl" : "skeleton", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.", + "xrefs" : [ "VSAO:0000026" ] + }, + "xrefs" : [ { + "val" : "AEO:0000168" + }, { + "val" : "EHDAA2:0001843" + }, { + "val" : "EHDAA:5047" + }, { + "val" : "EMAPA:17213" + }, { + "val" : "FMA:23875" + }, { + "val" : "GAID:177" + }, { + "val" : "MA:0003006" + }, { + "val" : "MAT:0000032" + }, { + "val" : "MESH:D012863" + }, { + "val" : "MIAA:0000032" + }, { + "val" : "SCTID:361378004" + }, { + "val" : "VSAO:0000026" + }, { + "val" : "Wikipedia:Skeleton" + }, { + "val" : "XAO:0004053" + }, { + "val" : "galen:Skeleton" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004290", "lbl" : "dermomyotome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bilaminar epithelium formed from the myotome and dermatome.", + "xrefs" : [ "AEO:0000214" ] + }, + "xrefs" : [ { + "val" : "AAO:0010572" + }, { + "val" : "AEO:0000214" + }, { + "val" : "EHDAA2:0003259" + }, { + "val" : "EMAPA:31109" + }, { + "val" : "FMA:295654" + }, { + "val" : "NCIT:C34140" + }, { + "val" : "TAO:0001513" + }, { + "val" : "VHOG:0000676" + }, { + "val" : "ZFA:0001513" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004291", "lbl" : "heart rudiment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.", + "xrefs" : [ "GO:0003313" ] + }, + "xrefs" : [ { + "val" : "TAO:0000115" + }, { + "val" : "ZFA:0000115" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004292", "lbl" : "cardiac skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart.", + "xrefs" : [ "GO:0003204", "Wikipedia:Cardiac_skeleton" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36645" + }, { + "val" : "FMA:9496" + }, { + "val" : "Wikipedia:Cardiac_skeleton" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004297", "lbl" : "respiratory system blood vessel smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001806" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004345", "lbl" : "trophectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition.", + "xrefs" : [ "MP:0005028" ] + }, + "xrefs" : [ { + "val" : "BTO:0001840" + }, { + "val" : "EHDAA2:0002091" + }, { + "val" : "EHDAA:56" + }, { + "val" : "EMAPA:16046" + }, { + "val" : "VHOG:0000979" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004348", "lbl" : "optic eminence", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic structure that gives rise to the corneal ectoderm.", + "xrefs" : [ "MP:0006305" ] + }, + "xrefs" : [ { + "val" : "EHDAA:938" + }, { + "val" : "EMAPA:16322" + }, { + "val" : "RETIRED_EHDAA2:0001308" + }, { + "val" : "VHOG:0001296" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004356", "lbl" : "apical ectodermal ridge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP].", + "xrefs" : [ "MP:0001676", "Wikipedia:Apical_ectodermal_ridge" ] + }, + "xrefs" : [ { + "val" : "AAO:0010760" + }, { + "val" : "EMAPA:32744" + }, { + "val" : "NCIT:C34109" + }, { + "val" : "TAO:0002146" + }, { + "val" : "Wikipedia:Apical_ectodermal_ridge" + }, { + "val" : "XAO:0004121" + }, { + "val" : "ZFA:0001702" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004357", "lbl" : "paired limb/fin bud", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP].", + "xrefs" : [ "ISBN:9780878932504", "MP:0005650", "https://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056]" ], + "xrefs" : [ { + "val" : "VHOG:0001258" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004362", "lbl" : "pharyngeal arch 1", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010364" + }, { + "val" : "CALOHA:TS-2089" + }, { + "val" : "EHDAA2:0000006" + }, { + "val" : "EHDAA:573" + }, { + "val" : "EMAPA:16118" + }, { + "val" : "FMA:293019" + }, { + "val" : "MFMO:0000095" + }, { + "val" : "NCIT:C34175" + }, { + "val" : "SCTID:308767008" + }, { + "val" : "TAO:0001595" + }, { + "val" : "VHOG:0000296" + }, { + "val" : "Wikipedia:First_pharyngeal_arch" + }, { + "val" : "XAO:0000097" + }, { + "val" : "ZFA:0001612" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004363", "lbl" : "pharyngeal arch artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP].", + "xrefs" : [ "MP:0002672" ] + }, + "xrefs" : [ { + "val" : "AAO:0010414" + }, { + "val" : "EFO:0003695" + }, { + "val" : "EHDAA2:0000186" + }, { + "val" : "EHDAA:398" + }, { + "val" : "EHDAA:7327" + }, { + "val" : "EMAPA:16684" + }, { + "val" : "NCIT:C32123" + }, { + "val" : "TAO:0005004" + }, { + "val" : "VHOG:0000122" + }, { + "val" : "Wikipedia:Aortic_arches" + }, { + "val" : "XAO:0000341" + }, { + "val" : "ZFA:0005004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004364", "lbl" : "ectoplacental cone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta.", + "xrefs" : [ "MP:0001717", "PMID:19829370" ] + }, + "xrefs" : [ { + "val" : "BTO:0001715" + }, { + "val" : "EMAPA:16059" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004365", "lbl" : "vitelline blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Blood vessel that is connected to the yolk sac.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36494" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004367", "lbl" : "Descemet's membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP].", + "xrefs" : [ "MP:0004285", "https://github.com/obophenotype/uberon/issues/15" ] + }, + "comments" : [ "The strong, resistant, thin, noncellular fourth layer of the cornea, located between the endothelium (from which it is secreted) and the stroma. (Cline et al., Dictionary of Visual Science, 4th ed)" ], + "xrefs" : [ { + "val" : "EMAPA:18804" + }, { + "val" : "FMA:58309" + }, { + "val" : "GAID:894" + }, { + "val" : "MA:0001246" + }, { + "val" : "MESH:D003886" + }, { + "val" : "NCIT:C32454" + }, { + "val" : "SCTID:281076002" + }, { + "val" : "TAO:0002157" + }, { + "val" : "Wikipedia:Descemet%27s_membrane" + }, { + "val" : "ZFA:0001686" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004370", "lbl" : "anterior limiting lamina of cornea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane.", + "xrefs" : [ "ncithesaurus:Bowman_s_Membrane" ] + }, + "xrefs" : [ { + "val" : "FMA:58273" + }, { + "val" : "MA:0001240" + }, { + "val" : "NCIT:C32226" + }, { + "val" : "SCTID:281075003" + }, { + "val" : "TAO:0002155" + }, { + "val" : "Wikipedia:Bowman%27s_membrane" + }, { + "val" : "ZFA:0001684" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004374", "lbl" : "vitelline vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vascular network that is connected to the yolk sac.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Vitelline_circulation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004375", "lbl" : "bone of free limb or fin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of an appendage [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004451", + "lbl" : "trunk or cervical vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra.", + "xrefs" : [ "UBERONREF:0000006" ] + }, + "xrefs" : [ { + "val" : "MA:0002869" + }, { + "val" : "XAO:0003077" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004455", "lbl" : "neurula embryo", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryo at the neurula stage.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BILA:0000061" + }, { + "val" : "BTO:0001766" + }, { + "val" : "NCIT:C34229" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004456", "lbl" : "entire sense organ system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Sum of all sensory systems in an organism.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:78499" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004461", "lbl" : "skeletal musculature of head", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of skeletal muscles that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "This class is restricted to skeletal muscles that attach to the cranial skeleton. This seems to be consistent with FMA and EMAPA usage. Note that by definition this excludes invertebrate head musculature. It corresponds to the individual muscle organ term UBERON:0002376" ], + "xrefs" : [ { + "val" : "EMAPA:18171" + }, { + "val" : "FMA:71287" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004464", "lbl" : "musculature of thorax", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000508" + }, { + "val" : "FMA:71293" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004465", "lbl" : "musculature of neck", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000091" + }, { + "val" : "EMAPA:36050" + }, { + "val" : "FMA:71290" + }, { + "val" : "MESH:D009334" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004468", + "lbl" : "set of muscles of vertebral column", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:33061" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004469", "lbl" : "musculature of back", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:71291" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004471", "lbl" : "musculature of pectoral girdle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000423" + }, { + "val" : "FMA:33519" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004473", "lbl" : "musculature of face", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a face.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:71288" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004479", "lbl" : "musculature of trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0011572" + }, { + "val" : "EFO:0003531" + }, { + "val" : "FMA:50187" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004490", "lbl" : "cardiac muscle tissue of atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7283" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004491", "lbl" : "cardiac muscle tissue of interatrial septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:84083" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004492", "lbl" : "cardiac muscle tissue of cardiac septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:226279" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004493", "lbl" : "cardiac muscle tissue of myocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:261726" + }, { + "val" : "MA:0002441" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004495", "lbl" : "skeletal muscle tissue of diaphragm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:261898" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004515", "lbl" : "smooth muscle tissue of bronchiole", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:261045" } ] } }, { @@ -20114,9 +68849,12 @@ "lbl" : "smooth muscle tissue of terminal bronchiole", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:261051" } ] } }, { @@ -20124,27 +68862,132 @@ "lbl" : "smooth muscle tissue of respiratory bronchiole", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:261055" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004518", + "lbl" : "muscle of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle that is attached to a vertebra of the vertebral column.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:22594" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004521", "lbl" : "vasculature of muscle organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a muscle organ [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:87123" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004522", "lbl" : "vasculature of musculoskeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a musculoskeletal system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:239607" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004525", + "lbl" : "cardiac muscle tissue of trabecula carnea of right ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:84429" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004526", + "lbl" : "cardiac muscle tissue of trabecula carnea of left ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:84430" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004535", "lbl" : "cardiovascular system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical system that has as its parts the heart and blood vessels.", + "xrefs" : [ "BTO:0000088" ] + }, + "xrefs" : [ { + "val" : "AAO:0011001" + }, { + "val" : "BILA:0000016" + }, { + "val" : "BTO:0000088" + }, { + "val" : "CALOHA:TS-1297" + }, { + "val" : "EFO:0000791" + }, { + "val" : "EHDAA:394" + }, { + "val" : "EMAPA:16104" + }, { + "val" : "EV:0100017" + }, { + "val" : "FMA:7161" + }, { + "val" : "GAID:467" + }, { + "val" : "MA:0000010" + }, { + "val" : "MAT:0000016" + }, { + "val" : "MESH:D002319" + }, { + "val" : "MIAA:0000016" + }, { + "val" : "NCIT:C12686" + }, { + "val" : "SCTID:278198007" + }, { + "val" : "TAO:0000010" + }, { + "val" : "VHOG:0000302" + }, { + "val" : "WikipediaCategory:Cardiovascular_system" + }, { + "val" : "XAO:0000100" + }, { + "val" : "XAO:0001010" + }, { + "val" : "ZFA:0000010" } ] } }, { @@ -20152,31 +68995,94 @@ "lbl" : "blood vasculature", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A vascular network consisting of blood vessels.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001079" + }, { + "val" : "ZFA:0001079" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004548", "lbl" : "left eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An eye that is part of a left side of organism [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:12515" + }, { + "val" : "MA:0002949" + }, { + "val" : "NCIT:C119334" + }, { + "val" : "SCTID:362503005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004549", "lbl" : "right eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An eye that is part of a right side of organism [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:12514" + }, { + "val" : "MA:0002950" + }, { + "val" : "NCIT:C119333" + }, { + "val" : "SCTID:362502000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004571", "lbl" : "systemic arterial system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart.", + "xrefs" : [ "Wikipedia:Systemic_circulation#Arteries", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:45623" + }, { + "val" : "Wikipedia:Systemic_circulation#Arteries" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004572", "lbl" : "arterial system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the cardiovascular system consisting of all arteries.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004690" + }, { + "val" : "EHDAA2:0000143" + }, { + "val" : "EHDAA:396" + }, { + "val" : "EMAPA:16201" + }, { + "val" : "EMAPA:16371" + }, { + "val" : "MA:0002719" + }, { + "val" : "SCTID:362030008" + }, { + "val" : "VHOG:0000273" } ] } }, { @@ -20184,23 +69090,73 @@ "lbl" : "systemic artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart.", + "xrefs" : [ "Wikipedia:Artery#Systemic_arteries", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:66464" + }, { + "val" : "Wikipedia:Artery#Systemic_arteries" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004581", "lbl" : "systemic venous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the venous system that drains the general body tissues[Kardong].", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Systemic_venous_system" ] + }, + "xrefs" : [ { + "val" : "FMA:45626" + }, { + "val" : "Wikipedia:Systemic_venous_system" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004582", "lbl" : "venous system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004692" + }, { + "val" : "EHDAA2:0002171" + }, { + "val" : "EHDAA:486" + }, { + "val" : "EMAPA:16240" + }, { + "val" : "MA:0002720" + }, { + "val" : "NCIT:C33858" + }, { + "val" : "SCTID:362060003" + }, { + "val" : "VHOG:0000277" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004590", + "lbl" : "sphincter muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.", + "xrefs" : [ "Wikipedia:Sphincter" ] + }, + "xrefs" : [ { + "val" : "FMA:75004" + }, { + "val" : "NCIT:C28381" + }, { + "val" : "Wikipedia:Sphincter" } ] } }, { @@ -20208,219 +69164,1106 @@ "lbl" : "blood vessel endothelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000766" + }, { + "val" : "CALOHA:TS-2155" + }, { + "val" : "EMAPA:35176" + }, { + "val" : "MA:0000709" + }, { + "val" : "NCIT:C53395" + }, { + "val" : "TAO:0005257" + }, { + "val" : "ZFA:0005257" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "lbl" : "liver lobule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0008987" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35499" + }, { + "val" : "FMA:14471" + }, { + "val" : "MA:0002494" + }, { + "val" : "NCIT:C32732" + }, { + "val" : "SCTID:362194004" + }, { + "val" : "Wikipedia:Lobules_of_liver" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004663", "lbl" : "aorta wall", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of an aorta, enclosing the luminal space.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35139" + }, { + "val" : "FMA:14156" + }, { + "val" : "MA:0002901" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004664", "lbl" : "aorta tunica adventitia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0009871" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35136" + }, { + "val" : "FMA:14283" + }, { + "val" : "MA:0002902" + }, { + "val" : "SCTID:24996002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004666", "lbl" : "interventricular septum membranous part", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The membranous portion of the wall between the two lower chambers of the heart.", + "xrefs" : [ "MP:0008823" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004596" + }, { + "val" : "EMAPA:18246" + }, { + "val" : "FMA:7135" + }, { + "val" : "MA:0002939" + }, { + "val" : "SCTID:278228007" + }, { + "val" : "VHOG:0000927" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004667", "lbl" : "interventricular septum muscular part", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The muscular portion of the wall between the two lower chambers of the heart.", + "xrefs" : [ "Wikipedia:Interventricular_septum#Portions", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000885" + }, { + "val" : "EHDAA:2607" + }, { + "val" : "EMAPA:18247" + }, { + "val" : "FMA:7134" + }, { + "val" : "MA:0002940" + }, { + "val" : "RETIRED_EHDAA2:0000888" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004684", "lbl" : "raphe nuclei", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane.", + "xrefs" : [ "NLXANAT:20090205", "https://sourceforge.net/tracker/?func=detail&aid=3248146&group_id=36855&atid=440764" ] + }, + "comments" : [ "we treat NR obscurus, NR magnus etc as parts of the raphe nuclei. This is consistent with treatment in FMA, where the class is 'set of raphe nuclei'" ], + "xrefs" : [ { + "val" : "BAMS:RA" + }, { + "val" : "EMAPA:35721" + }, { + "val" : "FMA:84017" + }, { + "val" : "MA:0003147" + }, { + "val" : "MESH:D011903" + }, { + "val" : "NCIT:C97335" + }, { + "val" : "NLXANAT:20090205" + }, { + "val" : "TAO:0001429" + }, { + "val" : "Wikipedia:Raphe_nuclei" + }, { + "val" : "ZFA:0001429" + }, { + "val" : "neuronames:2495" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004688", "lbl" : "costo-cervical trunk", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Costocervical_trunk" ] + }, + "xrefs" : [ { + "val" : "FMA:10636" + }, { + "val" : "MA:0001939" + }, { + "val" : "SCTID:244225009" + }, { + "val" : "Wikipedia:Costocervical_trunk" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004695", "lbl" : "arterial system smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36503" + }, { + "val" : "MA:0000704" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004696", "lbl" : "venous system smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36613" + }, { + "val" : "MA:0000715" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004698", "lbl" : "vena cava endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a vena cava [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000713" + }, { + "val" : "NCIT:C49318" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004699", "lbl" : "outflow tract endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a outflow tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000490" + }, { + "val" : "VHOG:0001524" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004700", "lbl" : "arterial system endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of an arterial system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35145" + }, { + "val" : "MA:0000703" + }, { + "val" : "NCIT:C49329" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004701", "lbl" : "venous system endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a venous system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35907" + }, { + "val" : "MA:0000714" + }, { + "val" : "NCIT:C49320" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004702", "lbl" : "respiratory system blood vessel endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel endothelium that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35732" + }, { + "val" : "MA:0001805" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004706", "lbl" : "bulbus cordis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010568" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000197" + }, { + "val" : "EHDAA:438" + }, { + "val" : "EHDAA:768" + }, { + "val" : "EMAPA:16333" + }, { + "val" : "FMA:70300" + }, { + "val" : "NCIT:C34114" + }, { + "val" : "SCTID:361525002" + }, { + "val" : "Wikipedia:Bulbus_cordis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004708", "lbl" : "paired limb/fin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An appendage that is part of an appendage girdle complex.", + "xrefs" : [ "UBERON:cjm", "https://github.com/geneontology/go-ontology/issues/9029" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000067" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004710", "lbl" : "pectoral appendage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues.", + "xrefs" : [ "VSAO:0000150-modified" ] + }, + "xrefs" : [ { + "val" : "VHOG:0001753" + }, { + "val" : "VSAO:0000125" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004711", "lbl" : "jugular vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava.", + "xrefs" : [ "Wikipedia:Jugular_vein" ] + }, + "xrefs" : [ { + "val" : "BTO:0001744" + }, { + "val" : "CALOHA:TS-0497" + }, { + "val" : "EMAPA:18638" + }, { + "val" : "GAID:536" + }, { + "val" : "MA:0002154" + }, { + "val" : "MESH:D007601" + }, { + "val" : "NCIT:C12738" + }, { + "val" : "SCTID:244403000" + }, { + "val" : "Wikipedia:Jugular_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004716", "lbl" : "conceptus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP].", + "xrefs" : [ "BTO:0003834", "Wikipedia:Conceptus" ] + }, + "xrefs" : [ { + "val" : "AEO:0000194" + }, { + "val" : "BTO:0003834" + }, { + "val" : "EHDAA2:0000001" + }, { + "val" : "EHDAA2:0003235" + }, { + "val" : "EMAPA:36040" + }, { + "val" : "NCIT:C34131" + }, { + "val" : "Wikipedia:Conceptus" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004731", "lbl" : "neuromere", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres).", + "xrefs" : [ "DOI:10.1016/j.tins.2013.06.004", "https://github.com/obophenotype/uberon/issues/318" ] + }, + "xrefs" : [ { + "val" : "NLX:147842" + }, { + "val" : "TAO:0001328" + }, { + "val" : "Wikipedia:Neuromere" + }, { + "val" : "ZFA:0001328" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004732", "lbl" : "segmental subdivision of nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres.", + "xrefs" : [ "FBbt:00005140", "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004733", "lbl" : "segmental subdivision of hindbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ subunit that is part of a hindbrain [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:61998" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004734", "lbl" : "gastrula", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organism at the gastrula stage.", + "xrefs" : [ "Wikipedia:Gastrula", "Wikipedia:Trilaminar_blastocyst" ] + }, + "xrefs" : [ { + "val" : "BILA:0000060" + }, { + "val" : "BTO:0001403" + }, { + "val" : "FMA:293108" + }, { + "val" : "GAID:1302" + }, { + "val" : "MESH:D005775" + }, { + "val" : "MIAA:0000179" + }, { + "val" : "NCIT:C34057" + }, { + "val" : "NCIT:C34058" + }, { + "val" : "Wikipedia:Gastrula" + }, { + "val" : "Wikipedia:Trilaminar_blastocyst" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004755", "lbl" : "skeletal tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000015", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/134" ] + }, + "comments" : [ "Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from" ], + "xrefs" : [ { + "val" : "MA:0003047" + }, { + "val" : "SCTID:309311006" + }, { + "val" : "VSAO:0000015" + }, { + "val" : "XAO:0004038" + }, { + "val" : "ZFA:0005619" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004756", "lbl" : "dermal skeletal element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dermis-derived entity that is made of skeletal tissue.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/206" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004760", + "lbl" : "gland of anal canal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of an anal canal [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic", "Wikipedia:Anal_gland" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27221" + }, { + "val" : "EMAPA:27233" + }, { + "val" : "EMAPA:27543" + }, { + "val" : "FMA:15720" + }, { + "val" : "FMA:15724" + }, { + "val" : "NCIT:C32068" + }, { + "val" : "SCTID:245448005" + }, { + "val" : "Wikipedia:Anal_gland" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004761", "lbl" : "cartilaginous neurocranium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP].", + "xrefs" : [ "Wikipedia:Chondrocranium" ] + }, + "xrefs" : [ { + "val" : "AAO:0000094" + }, { + "val" : "EHDAA:6031" + }, { + "val" : "FMA:76621" + }, { + "val" : "NCIT:C34121" + }, { + "val" : "SCTID:155540009" + }, { + "val" : "Wikipedia:Chondrocranium" + }, { + "val" : "XAO:0003059" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004764", "lbl" : "intramembranous bone tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].", + "xrefs" : [ "GO:0001957", "Wikipedia:Intramembranous_ossification" ] + }, + "xrefs" : [ { + "val" : "MA:0002837" + }, { + "val" : "Wikipedia:Intramembranous_ossification" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004765", "lbl" : "skeletal element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011129" + }, { + "val" : "TAO:0001890" + }, { + "val" : "VSAO:0000128" + }, { + "val" : "XAO:0004012" + }, { + "val" : "ZFA:0005494" + }, { + "val" : "galen:SkeletalStructure" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004766", + "lbl" : "cranial bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a cranium.", + "xrefs" : [ "UBERON:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:181792001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004768", + "lbl" : "bone of lower jaw", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004770", + "lbl" : "articular system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that consists of all the joints of the body.", + "xrefs" : [ "VSAO:0000181" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35150" + }, { + "val" : "FMA:23878" + }, { + "val" : "MA:0003007" + }, { + "val" : "SCTID:361827000" + }, { + "val" : "VSAO:0000181" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004777", + "lbl" : "respiratory system submucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001822" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004779", + "lbl" : "respiratory system lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001821" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004780", + "lbl" : "gastrointestinal system lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a gastrointestinal system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001899" + }, { + "val" : "NCIT:C49299" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004781", + "lbl" : "gallbladder lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a gallbladder [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35371" + }, { + "val" : "FMA:278594" + }, { + "val" : "MA:0001633" + }, { + "val" : "NCIT:C49228" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004782", + "lbl" : "gastrointestinal system serosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a digestive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001522" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004783", + "lbl" : "gallbladder serosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a gallbladder [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35372" + }, { + "val" : "FMA:14659" + }, { + "val" : "MA:0001634" + }, { + "val" : "SCTID:362197006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004784", + "lbl" : "heart ventricle wall", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of a cardiac ventricle [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:13884" + }, { + "val" : "MA:0002791" + }, { + "val" : "NCIT:C119295" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004785", + "lbl" : "respiratory system mucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The mucous membrane lining the respiratory tract.", + "xrefs" : [ "MESH:A04.760", "MGI:cwg", "MP:0002277" ] + }, + "xrefs" : [ { + "val" : "BTO:0000973" + }, { + "val" : "FMA:302092" + }, { + "val" : "GAID:304" + }, { + "val" : "MA:0001827" + }, { + "val" : "MESH:D020545" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004786", + "lbl" : "gastrointestinal system mucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a gastrointestinal system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "The gut mucosa of amphioxus has insulin-secreting cells. http://www.ncbi.nlm.nih.gov/pubmed/16417468" ], + "xrefs" : [ { + "val" : "BTO:0000546" + }, { + "val" : "BTO:0005568" + }, { + "val" : "EMAPA:36591" + }, { + "val" : "MA:0001521" + }, { + "val" : "SCTID:410433007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004790", + "lbl" : "skin mucous gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucous gland that is part of the skin.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35775" + }, { + "val" : "MA:0000148" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004792", + "lbl" : "secretion of endocrine pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A secretion that is part of a endocrine pancreas [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002517" + }, { + "val" : "NCIT:C33255" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004766", - "lbl" : "cranial bone", + "id" : "http://purl.obolibrary.org/obo/UBERON_0004793", + "lbl" : "secretion of exocrine pancreas", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A secretion that is part of a exocrine pancreas [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002518" + }, { + "val" : "NCIT:C33256" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004768", - "lbl" : "bone of lower jaw", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004770", - "lbl" : "articular system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004777", - "lbl" : "respiratory system submucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004779", - "lbl" : "respiratory system lamina propria", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004780", - "lbl" : "gastrointestinal system lamina propria", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004782", - "lbl" : "gastrointestinal system serosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004784", - "lbl" : "heart ventricle wall", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004785", - "lbl" : "respiratory system mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004786", - "lbl" : "gastrointestinal system mucosa", - "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004794", "lbl" : "esophagus secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A secretion that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:79662" + }, { + "val" : "MA:0002514" + }, { + "val" : "NCIT:C52555" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004795", + "lbl" : "pancreas secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A secretion that is part of a pancreas [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002516" + }, { + "val" : "NCIT:C13270" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004797", "lbl" : "blood vessel layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36296" + }, { + "val" : "MA:0002854" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004802", "lbl" : "respiratory tract epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:anna", "MP:0010942" ] + }, + "xrefs" : [ { + "val" : "BTO:0000419" + }, { + "val" : "CALOHA:TS-0023" + }, { + "val" : "EMAPA:32827" + }, { + "val" : "MA:0001480" + }, { + "val" : "SCTID:321764001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004807", "lbl" : "respiratory system epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0023" + }, { + "val" : "EMAPA:32826" + }, { + "val" : "MA:0001823" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004808", "lbl" : "gastrointestinal system epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a digestive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32683" + }, { + "val" : "MA:0001520" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004815", "lbl" : "lower respiratory tract epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a lower respiratory tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001481" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "lbl" : "bile duct epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any epithelium that lines one of the bile ducts.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000417" + }, { + "val" : "MA:0001629" + }, { + "val" : "NCIT:C43616" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004821", "lbl" : "pulmonary alveolus epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO].", + "xrefs" : [ "BTO:0003511", "MP:0010898" ] + }, + "xrefs" : [ { + "val" : "BTO:0003511" + }, { + "val" : "EMAPA:35121" + }, { + "val" : "FMA:63915" + }, { + "val" : "MA:0001771" + }, { + "val" : "NCIT:C12867" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004822", + "lbl" : "extrahepatic bile duct epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a extrahepatic bile duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000742" + }, { + "val" : "EHDAA:3051" + }, { + "val" : "MA:0002661" + }, { + "val" : "NCIT:C43618" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004823", + "lbl" : "intrahepatic bile duct epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a intrahepatic bile duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000743" + }, { + "val" : "EHDAA:3053" + }, { + "val" : "MA:0002662" + }, { + "val" : "NCIT:C43617" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004830", "lbl" : "respiratory system skeletal muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001829" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004831", "lbl" : "esophagus skeletal muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "Most muscle tissue lining the digestive tract is smooth, but part of the externa of the esophagus is skeletal" ], + "xrefs" : [ { + "val" : "EMAPA:36523" + }, { + "val" : "MA:0001572" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004832", + "lbl" : "anal region skeletal muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001530" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004833", "lbl" : "lip skeletal muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001578" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004834", + "lbl" : "hepatic duct smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Smooth muscle tissue in all or part of a hepatic duct.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0001640" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004848", "lbl" : "respiratory system arterial endothelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelium of artery that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001801" } ] } }, { @@ -20428,782 +70271,4239 @@ "lbl" : "respiratory system venous endothelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelium of vein that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001811" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004851", "lbl" : "aorta endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall.", + "xrefs" : [ "MGI:csmith", "MP:0009864" ] + }, + "xrefs" : [ { + "val" : "BTO:0000394" + }, { + "val" : "CALOHA:TS-0047" + }, { + "val" : "EFO:0002597" + }, { + "val" : "EMAPA:35134" + }, { + "val" : "MA:0000701" + }, { + "val" : "NCIT:C49190" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004852", "lbl" : "cardiovascular system endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of the cardiovascular system.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001853" + }, { + "val" : "EMAPA:35201" + }, { + "val" : "GAID:519" + }, { + "val" : "MA:0000717" + }, { + "val" : "MESH:D004730" + }, { + "val" : "NCIT:C13053" + }, { + "val" : "TAO:0002171" + }, { + "val" : "VHOG:0001217" + }, { + "val" : "XAO:0000356" + }, { + "val" : "ZFA:0001639" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004854", + "lbl" : "gastrointestinal system mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a digestive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001900" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004857", "lbl" : "skeletal muscle connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A connective tissue that surrounds a skeletal muscle tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002868" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004859", "lbl" : "eye gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Examples: harderian gland, accessory lacrimal gland, gland of Moll, gland of Zeis, nictitating membrane glands" ], + "xrefs" : [ { + "val" : "EMAPA:35334" + }, { + "val" : "MA:0000267" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004861", "lbl" : "right lung alveolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An alveolus that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35997" + }, { + "val" : "MA:0001786" + }, { + "val" : "NCIT:C49278" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004862", "lbl" : "left lung alveolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An alveolus that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19182" + }, { + "val" : "MA:0001777" + }, { + "val" : "NCIT:C49251" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004864", "lbl" : "vasculature of retina", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A vasculature that is part of a retina [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:76552" + }, { + "val" : "MESH:D012171" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004867", + "lbl" : "orbital cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000343" + }, { + "val" : "FMA:84961" + }, { + "val" : "SCTID:280541000" + }, { + "val" : "Wikipedia:Orbit_(anatomy)" + }, { + "val" : "ZFA:0005558" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004872", "lbl" : "splanchnic layer of lateral plate mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP].", + "xrefs" : [ "Wikipedia:Lateral_plate_mesoderm#Division_into_layers" ] + }, + "xrefs" : [ { + "val" : "AAO:0011102" + }, { + "val" : "BILA:0000044" + }, { + "val" : "FMA:295568" + }, { + "val" : "Wikipedia:Lateral_plate_mesoderm#Division_into_layers" + }, { + "val" : "XAO:0000276" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004873", "lbl" : "splanchnopleure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP].", + "xrefs" : [ "Wikipedia:Splanchnopleure" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001903" + }, { + "val" : "EHDAA:383" + }, { + "val" : "EMAPA:16181" + }, { + "val" : "FMA:295564" + }, { + "val" : "NCIT:C34303" + }, { + "val" : "VHOG:0000558" + }, { + "val" : "Wikipedia:Splanchnopleure" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004874", "lbl" : "somatopleure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP].", + "xrefs" : [ "Wikipedia:Somatopleure" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001847" + }, { + "val" : "EHDAA:381" + }, { + "val" : "EMAPA:16180" + }, { + "val" : "FMA:295566" + }, { + "val" : "NCIT:C34301" + }, { + "val" : "VHOG:0000557" + }, { + "val" : "Wikipedia:Somatopleure" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004880", "lbl" : "chordamesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The central region of trunk mesoderm. This tissue forms the notochord.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000478" + }, { + "val" : "EFO:0003426" + }, { + "val" : "TAO:0000091" + }, { + "val" : "ZFA:0000091" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004883", "lbl" : "lung mesenchyme", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The mass of tissue made up of mesenchymal cells in the lung.", + "xrefs" : [ "GO:0060484" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32866" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004893", "lbl" : "interalveolar septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung.", + "xrefs" : [ "LG:0012625", "Wikipedia:Alveolar_septum" ] + }, + "xrefs" : [ { + "val" : "BTO:0003149" + }, { + "val" : "EMAPA:35433" + }, { + "val" : "MA:0000421" + }, { + "val" : "NCIT:C49473" + }, { + "val" : "Wikipedia:Alveolar_septum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004894", "lbl" : "alveolar wall", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A wall that contains the alveoli.", + "xrefs" : [ "LG:0012626", "MP:0010903" ] + }, + "xrefs" : [ { + "val" : "BTO:0002543" + }, { + "val" : "EMAPA:35120" + }, { + "val" : "FMA:14117" + }, { + "val" : "MA:0002568" + }, { + "val" : "NCIT:C13085" + }, { + "val" : "SCTID:361965008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004895", "lbl" : "alveolar smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus.", + "xrefs" : [ "LG:0012628" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35122" + }, { + "val" : "MA:0002759" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004904", "lbl" : "neuron projection bundle connecting eye with brain", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "for the vertebrate-specific structure, see UBERON:0000941 (cranial nerve II)" ], + "xrefs" : [ { + "val" : "BTO:0000966" + }, { + "val" : "EV:0100351" + }, { + "val" : "TADS:0000232" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004905", "lbl" : "articulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004906", "lbl" : "ectodermal part of digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of the gut that is derived from ectoderm.", + "xrefs" : [ "GO:0007439" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004907", + "lbl" : "lower digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition].", + "xrefs" : [ "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract" ] + }, + "xrefs" : [ { + "val" : "FMA:49179" + }, { + "val" : "NCIT:C33010" + }, { + "val" : "SCTID:279973004" + }, { + "val" : "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract" + }, { + "val" : "galen:LowerGastrointestinalTract" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004908", "lbl" : "upper digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum.", + "xrefs" : [ "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract" ] + }, + "xrefs" : [ { + "val" : "FMA:49177" + }, { + "val" : "NCIT:C33837" + }, { + "val" : "SCTID:181244000" + }, { + "val" : "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract" + }, { + "val" : "galen:UpperGastrointestinalTract" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004909", "lbl" : "epithelium of gonad", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium surrounding a gonad.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:4032" + }, { + "val" : "EHDAA:5931" + }, { + "val" : "NCIT:C32676" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004911", "lbl" : "epithelium of female gonad", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium surrounding an ovary.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0003661" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "lbl" : "biliary bud", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000171" + }, { + "val" : "EMAPA:16561" + }, { + "val" : "EMAPA_RETIRED:16565" + }, { + "val" : "VHOG:0001351" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004913", + "lbl" : "hepatopancreatic ampulla", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct.", + "xrefs" : [ "Wikipedia:Ampulla_of_Vater" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2348" + }, { + "val" : "FMA:15076" + }, { + "val" : "GAID:283" + }, { + "val" : "MESH:D014670" + }, { + "val" : "NCIT:C13011" + }, { + "val" : "SCTID:362200007" + }, { + "val" : "TAO:0005167" + }, { + "val" : "Wikipedia:Ampulla_of_Vater" + }, { + "val" : "ZFA:0005167" + }, { + "val" : "galen:AmpullaOfVater" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004914", + "lbl" : "duodenal papilla", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/duodenal+papilla" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18662" + }, { + "val" : "FMA:15953" + }, { + "val" : "MA:0003107" + }, { + "val" : "NCIT:C119578" + }, { + "val" : "SCTID:245389007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004915", + "lbl" : "sphincter of hepatopancreatic ampulla", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP].", + "xrefs" : [ "Wikipedia:Sphincter_of_ampulla" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18663" + }, { + "val" : "FMA:15077" + }, { + "val" : "GAID:285" + }, { + "val" : "MESH:D009803" + }, { + "val" : "NCIT:C13065" + }, { + "val" : "SCTID:181271000" + }, { + "val" : "Wikipedia:Sphincter_of_ampulla" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004916", + "lbl" : "anal sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphincter muscle that is part of a anal region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36052" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004921", "lbl" : "subdivision of digestive tract", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A proximal-distal subdivision of the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:71131" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004923", "lbl" : "organ component layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A part of a wall of an organ that forms a layer.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:82485" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004924", "lbl" : "submucosa of pharynx", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The tissue underlying the tunica mucosa of the pharynx.", + "xrefs" : [ "BTO:0002113" ] + }, + "xrefs" : [ { + "val" : "BTO:0002113" + }, { + "val" : "FMA:75144" + }, { + "val" : "SCTID:19594009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004926", + "lbl" : "submucosa of cystic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a cystic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18013" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004932", + "lbl" : "submucosa of sigmoid colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a sigmoid colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15027" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004934", + "lbl" : "submucosa of body of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a body of stomach [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:17059" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004936", + "lbl" : "submucosa of pyloric antrum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a pyloric antrum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:17060" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004937", + "lbl" : "submucosa of pylorus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a pylorus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27201" + }, { + "val" : "FMA:17462" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004938", + "lbl" : "submucosa of biliary tree", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a biliary tree [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004939", + "lbl" : "submucosa of common bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a common bile duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18011" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004940", + "lbl" : "submucosa of common hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a common hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18014" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004941", + "lbl" : "submucosa of right hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a right hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18015" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004942", + "lbl" : "submucosa of left hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a left hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18017" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004952", "lbl" : "submucosa of bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:62775" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004988", + "lbl" : "mucosa of cystic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a cystic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14690" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004993", + "lbl" : "mucosa of sigmoid colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a sigmoid colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15026" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004995", + "lbl" : "mucosa of body of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a body of stomach [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:17054" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004997", + "lbl" : "mucosa of pyloric antrum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a pyloric antrum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004107" + }, { + "val" : "FMA:17055" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004998", + "lbl" : "mucosa of pylorus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a pylorus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004110" + }, { + "val" : "EMAPA:27199" + }, { + "val" : "FMA:17461" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004999", + "lbl" : "mucosa of biliary tree", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a biliary tree [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14695" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005000", + "lbl" : "mucosa of common bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a common bile duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14688" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005001", + "lbl" : "mucosa of common hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a common hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14691" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005002", + "lbl" : "mucosa of right hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a right hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14692" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005003", + "lbl" : "mucosa of left hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a left hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14693" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005031", + "lbl" : "mucosa of upper lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a upper lip [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:59832" + }, { + "val" : "NCIT:C12224" + }, { + "val" : "SCTID:362088009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005032", "lbl" : "mucosa of lower lip", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a lower lip [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:59833" + }, { + "val" : "NCIT:C12225" + }, { + "val" : "SCTID:362089001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005033", + "lbl" : "mucosa of gallbladder", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a gallbladder [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14662" + }, { + "val" : "SCTID:362196002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005039", "lbl" : "mucosa of bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:62774" + }, { + "val" : "SCTID:10887006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005040", "lbl" : "mucosa of terminal bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a terminal bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:263232" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005041", "lbl" : "mucosa of respiratory bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a respiratory bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:263238" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005056", "lbl" : "external female genitalia", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_50557" + "definition" : { + "val" : "An external genitalia that is part of a female reproductive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547" ], + "xrefs" : [ { + "val" : "BTO:0003100" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "val" : "EMAPA:30984" + }, { + "val" : "FMA:45649" + }, { + "val" : "SCTID:362234008" + }, { + "val" : "galen:FemaleExternalGenitalia" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005057", "lbl" : "immune organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that is part of a immune system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005058", "lbl" : "hemolymphoid system gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a hemolymphoid system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18766" + }, { + "val" : "MA:0002962" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005061", "lbl" : "neural groove", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds.", + "xrefs" : [ "GO:0001842", "Wikipedia:Neural_groove", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011071" + }, { + "val" : "EMAPA:35594" + }, { + "val" : "FMA:295624" + }, { + "val" : "NCIT:C34224" + }, { + "val" : "SCTID:361463007" + }, { + "val" : "Wikipedia:Neural_groove" + }, { + "val" : "XAO:0000248" + }, { + "val" : "neuronames:1363" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005062", "lbl" : "neural fold", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the two elevated edges of the neural groove[GO,MP].", + "xrefs" : [ "GO:0001842", "MP:0011256", "Wikipedia:Neural_fold" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001249" + }, { + "val" : "FMA:295618" + }, { + "val" : "NCIT:C34223" + }, { + "val" : "SCTID:361461009" + }, { + "val" : "Wikipedia:Neural_fold" + }, { + "val" : "XAO:0004087" + }, { + "val" : "neuronames:1364" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005064", + "lbl" : "left ventricular trabecular myocardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Missing definition for term UBERON:0005064. Please replace it using linked reference.", + "xrefs" : [ "GO:0003225" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005066", + "lbl" : "right ventricular trabecular myocardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Missing definition for term UBERON:0005066. Please replace it using linked reference.", + "xrefs" : [ "GO:0003227" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005068", "lbl" : "neural rod", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN].", + "xrefs" : [ "GO:0014024", "ZFA:0000133" ] + }, + "xrefs" : [ { + "val" : "EFO:0003498" + }, { + "val" : "TAO:0000133" + }, { + "val" : "ZFA:0000133" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005076", "lbl" : "hindbrain-spinal cord boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005082", "lbl" : "tube lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hole in a tube[GO].", + "xrefs" : [ "GO:0060609" ] + }, + "xrefs" : [ { + "val" : "AEO:0000078" + }, { + "val" : "EHDAA2:0004618" + }, { + "val" : "RETIRED_EHDAA2:0003078" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005085", "lbl" : "ectodermal placode", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO].", + "xrefs" : [ "GO:0060788" ] + }, + "xrefs" : [ { + "val" : "AEO:0000218" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005090", "lbl" : "muscle structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO].", + "xrefs" : [ "GO:0061061" ] + }, + "xrefs" : [ { + "val" : "FMA:30316" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005092", "lbl" : "right horn of sinus venosus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001841" + }, { + "val" : "EHDAA:484" + }, { + "val" : "EMAPA:16239" + }, { + "val" : "FMA:70318" + }, { + "val" : "VHOG:0000489" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005153", "lbl" : "epithelial bud", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bud is a protrusion that forms from an epithelial sheet by localized folding.", + "xrefs" : [ "GO:0060572" ] + }, + "xrefs" : [ { + "val" : "BTO:0001639" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005156", "lbl" : "reproductive structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any anatomical structure that is part of the reproductive system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005157", "lbl" : "epithelial fold", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial sheet bent on a linear axis.", + "xrefs" : [ "GO:0060571" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005158", "lbl" : "parenchyma of central nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The functional tissue of the central nervous system consisting of neurons and glial cells.", + "xrefs" : [ "CL:tm", "https://github.com/obophenotype/uberon/issues/8" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005162", "lbl" : "multi cell part structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part.", + "xrefs" : [ "CARO:0001000" ] + }, + "xrefs" : [ { + "val" : "AAO:0011000" + }, { + "val" : "CARO:0001000" + }, { + "val" : "FMA:83115" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005169", "lbl" : "interstitial tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Connective tissue between the cellular elements of a structure.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/tissue" ] + }, + "xrefs" : [ { + "val" : "FMA:86301" + }, { + "val" : "SCTID:85293002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005171", + "lbl" : "hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000741" + }, { + "val" : "EHDAA:3049" + }, { + "val" : "EMAPA:16843" + }, { + "val" : "FMA:71891" + }, { + "val" : "MA:0000357" + }, { + "val" : "NCIT:C32730" + }, { + "val" : "SCTID:245399002" + }, { + "val" : "VHOG:0000219" + }, { + "val" : "galen:HepaticDuct" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005172", "lbl" : "abdomen element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000522" + }, { + "val" : "SCTID:272631008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005173", "lbl" : "abdominal segment element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000529" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005174", "lbl" : "dorsal region element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0001901" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005177", "lbl" : "trunk region element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000516" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005178", "lbl" : "thoracic cavity element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000557" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005181", "lbl" : "thoracic segment organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000563" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005194", "lbl" : "thoracic vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002235" + }, { + "val" : "NCIT:C53142" + }, { + "val" : "SCTID:281472008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005203", + "lbl" : "trachea gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen.", + "xrefs" : [ "ISBN:1451113412", "MGI:Anna", "PMID:15973734", "http://medical-dictionary.thefreedictionary.com/tracheal+glands", "https://github.com/obophenotype/uberon/issues/1197" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36574" + }, { + "val" : "FMA:7473" + }, { + "val" : "MA:0002937" + }, { + "val" : "SCTID:197423006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005221", + "lbl" : "liver right lobe parenchyma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A parenchyma that is part of a right lobe of liver [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001010" + }, { + "val" : "EMAPA:18317" + }, { + "val" : "FMA:71657" + }, { + "val" : "VHOG:0000840" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005222", + "lbl" : "liver left lobe parenchyma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A parenchyma that is part of a left lobe of liver [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001002" + }, { + "val" : "EMAPA:18310" + }, { + "val" : "FMA:71658" + }, { + "val" : "VHOG:0000839" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005233", + "lbl" : "medial-nasal process ectoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ectoderm that is part of a medial nasal prominence [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001078" + }, { + "val" : "EMAPA:16809" + }, { + "val" : "FMA:312675" + }, { + "val" : "VHOG:0000803" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005234", "lbl" : "optic eminence ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ectoderm that is part of a optic eminence [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:940" + }, { + "val" : "EMAPA:16539" + }, { + "val" : "RETIRED_EHDAA2:0001309" + }, { + "val" : "VHOG:0001105" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005239", "lbl" : "basal plate metencephalon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001154" + }, { + "val" : "EMAPA:17078" + }, { + "val" : "VHOG:0000320" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005243", "lbl" : "interventricular septum endocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endocardium that is part of a interventricular septum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000886" + }, { + "val" : "EHDAA2:0000887" + }, { + "val" : "FMA:83584" + }, { + "val" : "VHOG:0000615" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005248", "lbl" : "bulbus cordis myocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myocardium that is part of a bulbus cordis [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36488" + }, { + "val" : "VHOG:0000609" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005250", "lbl" : "stomatodeum gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a stomodeum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "VHOG:0000658" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005251", "lbl" : "yolk sac cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that is part of a yolk sac [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16055" + }, { + "val" : "FMA:63942" + }, { + "val" : "VHOG:0000843" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005253", "lbl" : "head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells.", + "xrefs" : [ "ISBN:0683400088", "MP:0011260" ] + }, + "xrefs" : [ { + "val" : "EFO:0003492" + }, { + "val" : "EHDAA2:0000732" + }, { + "val" : "EHDAA:179" + }, { + "val" : "EMAPA:16098" + }, { + "val" : "EMAPA_RETIRED:16269" + }, { + "val" : "FMA:76622" + }, { + "val" : "TAO:0000113" + }, { + "val" : "VHOG:0000332" + }, { + "val" : "ZFA:0000113" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005256", "lbl" : "trunk mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing trunk.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003485" + }, { + "val" : "EHDAA2:0002092" + }, { + "val" : "EHDAA:377" + }, { + "val" : "EMAPA:16177" + }, { + "val" : "TAO:0000081" + }, { + "val" : "VHOG:0000281" + }, { + "val" : "ZFA:0000081" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005290", "lbl" : "myelencephalon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP].", + "xrefs" : [ "BTO:0000758", "Wikipedia:Myelencephalon" ] + }, + "xrefs" : [ { + "val" : "BTO:0000758" + }, { + "val" : "CALOHA:TS-0607" + }, { + "val" : "CALOHA:TS-2365" + }, { + "val" : "DHBA:10662" + }, { + "val" : "EHDAA2:0001207" + }, { + "val" : "EHDAA:5526" + }, { + "val" : "EMAPA:17082" + }, { + "val" : "HBA:9512" + }, { + "val" : "MA:0000205" + }, { + "val" : "VHOG:0000456" + }, { + "val" : "Wikipedia:Myelencephalon" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005291", "lbl" : "embryonic tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of tissue that is part of an embryo.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2100" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005292", "lbl" : "extraembryonic tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0003360" + }, { + "val" : "CALOHA:TS-2119" + }, { + "val" : "EFO:0001406" + }, { + "val" : "MAT:0000061" + }, { + "val" : "MIAA:0000061" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005316", "lbl" : "endocardial endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The endothelial lining of the endocardium.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:83596" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005317", "lbl" : "pulmonary artery endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO].", + "xrefs" : [ "GO:0061155" ] + }, + "xrefs" : [ { + "val" : "BTO:0000137" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005334", "lbl" : "oral lamina propria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a mucosa of oral region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26947" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005337", "lbl" : "outflow tract of ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP].", + "xrefs" : [ "Wikipedia:Ventricular_outflow_tract" ] + }, + "xrefs" : [ { + "val" : "FMA:13225" + }, { + "val" : "Wikipedia:Ventricular_outflow_tract" + }, { + "val" : "XAO:0004140" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005338", "lbl" : "outflow tract aortic component", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An outflow tract that is part of a aorta.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001353" + }, { + "val" : "EMAPA:17329" + }, { + "val" : "MA:0000101" + }, { + "val" : "VHOG:0001394" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005339", "lbl" : "outflow tract pulmonary component", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001359" + }, { + "val" : "EHDAA:4401" + }, { + "val" : "EMAPA:17330" + }, { + "val" : "MA:0000102" + }, { + "val" : "VHOG:0001395" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005388", "lbl" : "photoreceptor array", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An array of photoreceptors and any supporting cells found in an eye.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005389", "lbl" : "transparent eye structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005396", "lbl" : "carotid artery segment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of: the common carotid artery, or its branches, the external and internal carotid arteries.", + "xrefs" : [ "Wikipedia:Carotid_artery", "https://sourceforge.net/tracker/?func=detail&aid=3486870&group_id=76834&atid=994764" ] + }, + "xrefs" : [ { + "val" : "AAO:0010217" + }, { + "val" : "BTO:0000168" + }, { + "val" : "CALOHA:TS-0116" + }, { + "val" : "EFO:0000818" + }, { + "val" : "EHDAA:6385" + }, { + "val" : "EMAPA:18609" + }, { + "val" : "EV:0100379" + }, { + "val" : "FMA:70504" + }, { + "val" : "GAID:478" + }, { + "val" : "MA:0001925" + }, { + "val" : "MAT:0000501" + }, { + "val" : "MESH:D002339" + }, { + "val" : "NCIT:C12687" + }, { + "val" : "SCTID:362040006" + }, { + "val" : "SCTID:69105007" + }, { + "val" : "TAO:0000097" + }, { + "val" : "VHOG:0000266" + }, { + "val" : "Wikipedia:Carotid_artery" + }, { + "val" : "ZFA:0000097" + }, { + "val" : "galen:CarotidArtery" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005398", "lbl" : "female reproductive gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sex gland that is part of a female reproductive system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000254" + }, { + "val" : "MA:0000383" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005409", "lbl" : "alimentary part of gastrointestinal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the digestive system that excludes the hepatobiliary system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000058" + }, { + "val" : "CALOHA:TS-0407" + }, { + "val" : "EHDAA2:0000110" + }, { + "val" : "EHDAA:514" + }, { + "val" : "EMAPA:16246" + }, { + "val" : "FMA:71132" + }, { + "val" : "GAID:294" + }, { + "val" : "MA:0000323" + }, { + "val" : "MESH:D041981" + }, { + "val" : "NCIT:C12378" + }, { + "val" : "SCTID:373871007" + }, { + "val" : "VHOG:0000412" + }, { + "val" : "galen:GastrointestinalTract" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005419", "lbl" : "pectoral appendage bud", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A limb bud that develops into a forelimb or pectoral fin.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "at this time we have no need to name a more specific 'pectoral fin bud' class, but we may in future" ], + "xrefs" : [ { + "val" : "EFO:0003430" + }, { + "val" : "TAO:0000141" + }, { + "val" : "VHOG:0001754" + }, { + "val" : "VHOG_RETIRED:0001259" + }, { + "val" : "ZFA:0000141" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005421", "lbl" : "pectoral appendage apical ectodermal ridge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An apical ectodermal ridge that is part of a pectoral appendage bud.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003487" + }, { + "val" : "EHDAA2:0000138" + }, { + "val" : "EMAPA:16778" + }, { + "val" : "TAO:0000085" + }, { + "val" : "TAO:0000736" + }, { + "val" : "VHOG:0001064" + }, { + "val" : "ZFA:0000085" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005423", "lbl" : "developing anatomical structure", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "xrefs" : [ { + "val" : "AEO:0000125" + }, { + "val" : "CALOHA:TS-2122" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "EHDAA2:0003125" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "FMA:292313" + }, { + "val" : "MIAA:0000019" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005425", "lbl" : "presumptive neural retina", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that is the inner layer of the optic cup and will become the neural retina.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001304" + }, { + "val" : "EMAPA:16675" + }, { + "val" : "TAO:0001071" + }, { + "val" : "VHOG:0000490" + }, { + "val" : "ZFA:0001071" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005426", "lbl" : "lens vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that gives rise to the lens.", + "xrefs" : [ "ZFIN:curator", "https://sourceforge.net/tracker/?func=detail&atid=994726&aid=3514998&group_id=76834" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000983" + }, { + "val" : "EHDAA:4737" + }, { + "val" : "EMAPA:17163" + }, { + "val" : "SCTID:361510002" + }, { + "val" : "TAO:0002205" + }, { + "val" : "VHOG:0001163" + }, { + "val" : "ZFA:0001679" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005427", "lbl" : "corneal primordium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea.", + "xrefs" : [ "ZFIN:ZDB-PUB-061010-3" ] + }, + "xrefs" : [ { + "val" : "TAO:0002188" + }, { + "val" : "ZFA:0001688" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005428", "lbl" : "vagal neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA].", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002156" + }, { + "val" : "EHDAA:669" + }, { + "val" : "TAO:0000818" + }, { + "val" : "VHOG:0001208" + }, { + "val" : "XAO:0004191" + }, { + "val" : "ZFA:0000818" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005432", "lbl" : "aortic sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates.", + "xrefs" : [ "MP:0012510" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004145" + }, { + "val" : "EHDAA:9826" + }, { + "val" : "EMAPA:36461" + }, { + "val" : "FMA:71008" + }, { + "val" : "RETIRED_EHDAA2:0000133" + }, { + "val" : "SCTID:361527005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005434", "lbl" : "cervical region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:24219" + }, { + "val" : "SCTID:123958008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005436", + "lbl" : "common hepatic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:.", + "xrefs" : [ "Wikipedia:Common_hepatic_artery" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000308" + }, { + "val" : "EHDAA:8570" + }, { + "val" : "FMA:14771" + }, { + "val" : "MA:0003094" + }, { + "val" : "SCTID:244263001" + }, { + "val" : "Wikipedia:Common_hepatic_artery" + }, { + "val" : "galen:CommonHepaticArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "lbl" : "foramen rotundum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa.", + "xrefs" : [ "Wikipedia:Foramen_rotundum" ] + }, + "xrefs" : [ { + "val" : "AAO:0000194" + }, { + "val" : "EHDAA2:0000552" + }, { + "val" : "EHDAA:10629" + }, { + "val" : "EMAPA:18712" + }, { + "val" : "FMA:53154" + }, { + "val" : "SCTID:369439002" + }, { + "val" : "VHOG:0001543" + }, { + "val" : "Wikipedia:Foramen_rotundum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005460", "lbl" : "left vitelline vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vitelline vein that is in the left side of a multicellular organism.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000971" + }, { + "val" : "EMAPA:16380" + }, { + "val" : "EMAPA:16698" + }, { + "val" : "FMA:70307" + }, { + "val" : "SCTID:361446008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005472", "lbl" : "right vitelline vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vitelline vein that is in the right side of a multicellular organism.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001766" + }, { + "val" : "EMAPA:16381" + }, { + "val" : "EMAPA:16699" + }, { + "val" : "FMA:70306" + }, { + "val" : "SCTID:361445007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005478", "lbl" : "sulcus limitans of neural tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD].", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/Sulcus+limitans", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + }, + "xrefs" : [ { + "val" : "BAMS:slim" + }, { + "val" : "BAMS:slm" + }, { + "val" : "neuronames:629" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005487", "lbl" : "vitelline vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The paired veins that carry blood from the yolk sac back to the embryo.", + "xrefs" : [ "MGI:csmith", "MP:0010666" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36021" + }, { + "val" : "FMA:70305" + }, { + "val" : "NCIT:C34329" + }, { + "val" : "RETIRED_EHDAA2:0002209" + }, { + "val" : "SCTID:2730004" + }, { + "val" : "SCTID:308832003" + }, { + "val" : "VHOG:0000401" + }, { + "val" : "Wikipedia:Vitelline_veins" + }, { + "val" : "XAO:0000376" + }, { + "val" : "XAO:0004147" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005496", "lbl" : "neural tube lateral wall", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue on the side of the lumen of the neural tube.", + "xrefs" : [ "ZFA:0001435" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001257" + }, { + "val" : "EHDAA:2873" + }, { + "val" : "EHDAA:912" + }, { + "val" : "EMAPA:16166" + }, { + "val" : "TAO:0001435" + }, { + "val" : "VHOG:0000513" + }, { + "val" : "ZFA:0001435" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005497", "lbl" : "non-neural ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998)." ], + "xrefs" : [ { + "val" : "EFO:0003643" + }, { + "val" : "EHDAA:257" + }, { + "val" : "EMAPA:16074" + }, { + "val" : "RETIRED_EHDAA2:0001273" + }, { + "val" : "TAO:0001178" + }, { + "val" : "VHOG:0001372" + }, { + "val" : "XAO:0004091" + }, { + "val" : "ZFA:0001178" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005498", "lbl" : "primitive heart tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that arises from the heart rudiment and will become the heart tube.", + "xrefs" : [ "ZFA:0000149" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001512" + }, { + "val" : "EHDAA:424" + }, { + "val" : "EHDAA:436" + }, { + "val" : "EMAPA:16215" + }, { + "val" : "FMA:321916" + }, { + "val" : "SCTID:361522004" + }, { + "val" : "TAO:0000149" + }, { + "val" : "Wikipedia:Primitive_heart_tube" + }, { + "val" : "ZFA:0000149" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005501", "lbl" : "rhombomere lateral wall", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural tube lateral wall that is part of a rhombomere.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32819" + }, { + "val" : "EMAPA:35364" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005563", "lbl" : "trigeminal neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cranial neural crest which gives rise to the trigeminal ganglion.", + "xrefs" : [ "ZFA:0000080" ] + }, + "xrefs" : [ { + "val" : "EFO:0003484" + }, { + "val" : "EHDAA2:0002083" + }, { + "val" : "EHDAA:667" + }, { + "val" : "EMAPA:16170" + }, { + "val" : "TAO:0000080" + }, { + "val" : "VHOG:0000269" + }, { + "val" : "ZFA:0000080" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005564", "lbl" : "gonad primordium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that gives rise to the immature gonad.", + "xrefs" : [ "ZFA:0001262" ] + }, + "xrefs" : [ { + "val" : "EFO:0003651" + }, { + "val" : "EHDAA:5927" + }, { + "val" : "EMAPA:17204" + }, { + "val" : "RETIRED_EHDAA2:0002148" + }, { + "val" : "TAO:0001262" + }, { + "val" : "WBbt:0008366" + }, { + "val" : "ZFA:0001262" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005594", "lbl" : "head somite", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Somite located in the head region, caudal to the otic vesicle.", + "xrefs" : [ "PMID:11830559" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0003437" + }, { + "val" : "EMAPA:16172" + }, { + "val" : "XAO:0000313" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005597", "lbl" : "lung primordium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum.", + "xrefs" : [ "XAO:0001002" ] + }, + "xrefs" : [ { + "val" : "AAO:0011059" + }, { + "val" : "EFO:0002578" + }, { + "val" : "EMAPA:36007" + }, { + "val" : "XAO:0001002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005598", "lbl" : "trunk somite", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A somite that is part of a trunk.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0010385" + }, { + "val" : "EHDAA2:0003438" + }, { + "val" : "EMAPA:16184" + }, { + "val" : "XAO:0000314" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005602", + "lbl" : "dorsal mesogastrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum.", + "xrefs" : [ "Wikipedia:Dorsal_mesentery" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000416" + }, { + "val" : "EHDAA:3001" + }, { + "val" : "EMAPA:17025" + }, { + "val" : "MA:0001618" + }, { + "val" : "NCIT:C34142" + }, { + "val" : "VHOG:0000352" + }, { + "val" : "Wikipedia:Dorsal_mesentery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005604", + "lbl" : "extrahepatic part of hepatic duct", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:16844" + }, { + "val" : "MA:0001636" + }, { + "val" : "VHOG:0000215" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005613", "lbl" : "left dorsal aorta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000936" + }, { + "val" : "EHDAA:404" + }, { + "val" : "EMAPA:16205" + }, { + "val" : "MA:0000478" + }, { + "val" : "SCTID:361403005" + }, { + "val" : "VHOG:0000484" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005614", "lbl" : "lens anterior epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000984" + }, { + "val" : "EHDAA:9059" + }, { + "val" : "EMAPA:17304" + }, { + "val" : "EMAPA:17839" + }, { + "val" : "FMA:70612" + }, { + "val" : "MA:0001302" + }, { + "val" : "NCIT:C33641" + }, { + "val" : "RETIRED_EHDAA2:0000976" + }, { + "val" : "SCTID:362521008" + }, { + "val" : "VHOG:0001425" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005616", + "lbl" : "mesenteric artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Arteries which arise from the abdominal aorta and distribute to most of the intestines.", + "xrefs" : [ "MESH:A07.231.114.565", "Wikipedia:Mesenteric_artery" ] + }, + "xrefs" : [ { + "val" : "BTO:0000779" + }, { + "val" : "EHDAA2:0001123" + }, { + "val" : "EHDAA:4343" + }, { + "val" : "EMAPA:17312" + }, { + "val" : "MA:0002003" + }, { + "val" : "MESH:D008638" + }, { + "val" : "NCIT:C52975" + }, { + "val" : "SCTID:281084003" + }, { + "val" : "VHOG:0001117" + }, { + "val" : "Wikipedia:Mesenteric_artery" + }, { + "val" : "XAO:0000370" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005617", + "lbl" : "mesenteric vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that returns blood from the intestines.", + "xrefs" : [ "MESH:A07.231.908.670.385", "Wikipedia:Mesenteric_vein" ] + }, + "xrefs" : [ { + "val" : "BTO:0002781" + }, { + "val" : "EHDAA:4442" + }, { + "val" : "EMAPA:17348" + }, { + "val" : "MA:0002177" + }, { + "val" : "MESH:D008642" + }, { + "val" : "NCIT:C53055" + }, { + "val" : "RETIRED_EHDAA2:0001125" + }, { + "val" : "SCTID:304045008" + }, { + "val" : "Wikipedia:Mesenteric_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005622", "lbl" : "right dorsal aorta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001720" + }, { + "val" : "EHDAA:406" + }, { + "val" : "EMAPA:16206" + }, { + "val" : "MA:0000479" + }, { + "val" : "SCTID:361404004" + }, { + "val" : "VHOG:0000485" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005631", "lbl" : "extraembryonic membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo.", + "xrefs" : [ "ISBN:0073040584" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004714" + }, { + "val" : "FMA:305915" + }, { + "val" : "SCTID:362840007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005637", + "lbl" : "pyloric region epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a pylorus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001582" + }, { + "val" : "EMAPA:17633" + }, { + "val" : "RETIRED_EHDAA2:0001927" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005638", "lbl" : "anterior chamber epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a anterior chamber of eyeball.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000130" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005656", "lbl" : "lens vesicle epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a lens vesicle.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000987" + }, { + "val" : "EMAPA:17165" + }, { + "val" : "VHOG:0000532" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005662", "lbl" : "4th arch ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ectoderm that is part of a pharyngeal arch 4.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004032" + }, { + "val" : "EMAPA:16762" + }, { + "val" : "EMAPA:16764" + }, { + "val" : "EMAPA:16768" + }, { + "val" : "RETIRED_EHDAA2:0000094" + }, { + "val" : "VHOG:0001095" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005666", "lbl" : "4th arch endoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endoderm that is part of a pharyngeal arch 4.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004033" + }, { + "val" : "EMAPA:16765" + }, { + "val" : "EMAPA:16767" + }, { + "val" : "EMAPA:16769" + }, { + "val" : "RETIRED_EHDAA2:0000095" + }, { + "val" : "VHOG:0001092" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005669", "lbl" : "peritoneal cavity mesothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelium that is part of a peritoneal cavity.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0003156" + }, { + "val" : "EHDAA2:0001447" + }, { + "val" : "EMAPA:16139" + }, { + "val" : "FMA:18147" + }, { + "val" : "SCTID:34073007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005672", "lbl" : "right lung endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a right lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001755" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005673", "lbl" : "left lung endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a left lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000961" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005685", + "lbl" : "midgut dorsal mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dorsal mesentery that is part of a midgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16722" + }, { + "val" : "EMAPA:17040" + }, { + "val" : "EMAPA:18671" + }, { + "val" : "RETIRED_EHDAA2:0001187" + }, { + "val" : "SCTID:361434009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005688", "lbl" : "lens vesicle cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that is part of a lens vesicle.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000986" + }, { + "val" : "EMAPA:17164" + }, { + "val" : "VHOG:0000531" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005691", "lbl" : "4th arch mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a pharyngeal arch 4.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000096" + }, { + "val" : "EHDAA:1677" + }, { + "val" : "EMAPA:16770" + }, { + "val" : "FMA:295702" + }, { + "val" : "VHOG:0001052" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005702", "lbl" : "optic eminence mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a optic eminence.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:942" + }, { + "val" : "EMAPA:16324" + }, { + "val" : "RETIRED_EHDAA2:0001310" + }, { + "val" : "VHOG:0001073" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "lbl" : "foregut duodenum mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery of duodenum that is part of a foregut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000564" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "lbl" : "midgut duodenum mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery of duodenum that is part of a midgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001193" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005720", "lbl" : "hindbrain venous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A venous system that is part of a hindbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000776" + }, { + "val" : "EMAPA:18632" + }, { + "val" : "VHOG:0001322" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005726", "lbl" : "chemosensory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BILA:0000139" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005728", "lbl" : "extraembryonic mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000474" + }, { + "val" : "EMAPA:31862" + }, { + "val" : "EMAPA:31863" + }, { + "val" : "FMA:296719" + }, { + "val" : "VHOG:0000616" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005729", "lbl" : "pectoral appendage field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0001453" + }, { + "val" : "ZFA:0001453" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005732", "lbl" : "paired limb/fin field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ring of cells capable of forming a limb or paired fin[Gilbert,modified].", + "xrefs" : [ "ISBN:9780878932504" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005734", "lbl" : "tunica adventitia of blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outermost layer of a blood vessel, composed mainly of fibrous tissue.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Tunica_externa_(vessels)" ] + }, + "xrefs" : [ { + "val" : "BTO:0002010" + }, { + "val" : "EMAPA:36299" + }, { + "val" : "NCIT:C33818" + }, { + "val" : "SCTID:61066005" + }, { + "val" : "Wikipedia:Tunica_externa_(vessels)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005740", "lbl" : "tunica intima of artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica intima that is part of a artery.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36293" + }, { + "val" : "EV:0100028" + }, { + "val" : "FMA:14272" + }, { + "val" : "SCTID:40022005" + }, { + "val" : "galen:IntimaOfArtery" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005742", "lbl" : "adventitia", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An outermost connective tissue covering of an organ, vessel, or other structure[WP].", + "xrefs" : [ "Wikipedia:Adventitia" ] + }, + "xrefs" : [ { + "val" : "BTO:0002010" + }, { + "val" : "FMA:45635" + }, { + "val" : "SCTID:30180000" + }, { + "val" : "Wikipedia:Adventitia" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005744", "lbl" : "bone foramen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves.", + "xrefs" : [ "TAO:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0010438" + }, { + "val" : "TAO:0001736" + }, { + "val" : "VHOG:0001760" + }, { + "val" : "ZFA:0005386" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005764", "lbl" : "acellular membrane", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "An acellular anatomical structure that is the bounding layer of a anatomical structure.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63871" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005769", "lbl" : "basement membrane of epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina.", + "xrefs" : [ "Wikipedia:Basement_membrane", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010596" + }, { + "val" : "FMA:63872" + }, { + "val" : "GAID:915" + }, { + "val" : "NCIT:C13191" + }, { + "val" : "SCTID:68989006" + }, { + "val" : "Wikipedia:Basement_membrane" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005800", "lbl" : "section of aorta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle.", + "xrefs" : [ "ncithesaurus:Aortic_Segment" ] + }, + "xrefs" : [ { + "val" : "FMA:13087" + }, { + "val" : "NCIT:C34027" + }, { + "val" : "SCTID:119203005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005805", "lbl" : "dorsal aorta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.", + "xrefs" : [ "GO:0035907", "https://sourceforge.net/p/geneontology/ontology-requests/8525/" ] + }, + "xrefs" : [ { + "val" : "AAO:0011029" + }, { + "val" : "BTO:0004673" + }, { + "val" : "EHDAA:402" + }, { + "val" : "EMAPA:18606" + }, { + "val" : "SCTID:338637006" + }, { + "val" : "TAO:0000014" + }, { + "val" : "VHOG:0000264" + }, { + "val" : "Wikipedia:Dorsal_aorta" + }, { + "val" : "XAO:0000051" + }, { + "val" : "ZFA:0000014" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005806", + "lbl" : "portal system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP].", + "xrefs" : [ "Wikipedia:Portal_venous_system" ] + }, + "xrefs" : [ { + "val" : "FMA:45628" + }, { + "val" : "MESH:D011168" + }, { + "val" : "NCIT:C33344" + }, { + "val" : "SCTID:362063001" + }, { + "val" : "Wikipedia:Portal_venous_system" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005844", "lbl" : "spinal cord segment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BIRNLEX:2665" + }, { + "val" : "FMA:62420" + }, { + "val" : "MA:0003080" + }, { + "val" : "SCTID:278748001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005845", + "lbl" : "caudal segment of spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A spinal cord segment that adjacent_to a caudal region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "for spinal cord segments, we treat coccygeal/caudal as synonyms - we only differentiate where bone is concerned" ], + "xrefs" : [ { + "val" : "FMA:256635" + }, { + "val" : "MA:0003084" + }, { + "val" : "SCTID:278753006" + }, { + "val" : "neuronames:1656" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005856", "lbl" : "developing mesenchymal condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A delimited region of dense mesenchyme within looser mesenchyme.", + "xrefs" : [ "AEO:0000148" ] + }, + "xrefs" : [ { + "val" : "AEO:0000148" + }, { + "val" : "EHDAA2_RETIRED:0003148" + }, { + "val" : "EHDAA:8979" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005863", "lbl" : "cartilaginous condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes.", + "xrefs" : [ "GO:curator" ] + }, + "xrefs" : [ { + "val" : "AEO:0000147" + }, { + "val" : "EHDAA2_RETIRED:0003147" + }, { + "val" : "EMAPA:32731" + }, { + "val" : "VSAO:0000092" + }, { + "val" : "XAO:0004022" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005865", "lbl" : "pre-muscle condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "AEO:0000149" + }, { + "val" : "EHDAA2_RETIRED:0003149" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005866", "lbl" : "pre-cartilage condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts.", + "xrefs" : [ "AEO:0000150", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000150" + }, { + "val" : "EHDAA2:0003150" + }, { + "val" : "EMAPA:32736" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005867", "lbl" : "mandibular prominence", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010939" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001061" + }, { + "val" : "EHDAA:5871" + }, { + "val" : "EMAPA:17355" + }, { + "val" : "FMA:293051" + }, { + "val" : "NCIT:C34204" + }, { + "val" : "Wikipedia:Mandibular_prominence" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005868", + "lbl" : "maxillary prominence", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010940" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001070" + }, { + "val" : "EHDAA:5877" + }, { + "val" : "EMAPA:17359" + }, { + "val" : "FMA:293049" + }, { + "val" : "NCIT:C34206" + }, { + "val" : "SCTID:346355001" + }, { + "val" : "Wikipedia:Maxillary_prominence" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005902", "lbl" : "occipital region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles.", + "xrefs" : [ "TAO:0001414", "UBERONREF:0000007" ] + }, + "xrefs" : [ { + "val" : "AAO:0010199" + }, { + "val" : "BTO:0004675" + }, { + "val" : "FMA:49187" + }, { + "val" : "SCTID:362618001" + }, { + "val" : "TAO:0001414" + }, { + "val" : "XAO:0003173" + }, { + "val" : "ZFA:0001414" + }, { + "val" : "neuronames:2431" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005906", "lbl" : "serous sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA].", + "xrefs" : [ "FMA:9689", "https://github.com/obophenotype/uberon/issues/86" ] + }, + "comments" : [ "See notes for serous membrane" ], + "xrefs" : [ { + "val" : "FMA:9689" + }, { + "val" : "SCTID:362890006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005911", "lbl" : "endo-epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA].", + "xrefs" : [ "FMA:69065" ] + }, + "xrefs" : [ { + "val" : "FMA:69065" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005944", "lbl" : "axial skeleton plus cranial skeleton", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified].", + "xrefs" : [ "FMA:71221", "VSAO:0000056", "Wikipedia:Axial_skeleton", "https://github.com/obophenotype/uberon/issues/44", "https://github.com/obophenotype/uberon/wiki/The-axial-skeleton" ] + }, + "xrefs" : [ { + "val" : "AAO:0000963" + }, { + "val" : "EMAPA:17214" + }, { + "val" : "MA:0000308" + }, { + "val" : "NCIT:C32172" + }, { + "val" : "SCTID:361725000" + }, { + "val" : "VSAO:0000056" + }, { + "val" : "Wikipedia:Axial_skeleton" + }, { + "val" : "XAO:0004011" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005945", + "lbl" : "neurocranial trabecula", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EFO:0003677" + }, { + "val" : "TAO:0001321" + }, { + "val" : "ZFA:0001321" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005946", "lbl" : "outflow tract of atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An outflow tract that is part of a cardiac atrium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14141" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005953", "lbl" : "outflow part of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk.", + "xrefs" : [ "MP:0010428" ] + }, + "xrefs" : [ { + "val" : "FMA:7216" + }, { + "val" : "NCIT:C61368" + }, { + "val" : "SCTID:244379003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005956", "lbl" : "outflow part of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta.", + "xrefs" : [ "MP:0010429" ] + }, + "xrefs" : [ { + "val" : "FMA:9473" + }, { + "val" : "SCTID:264070001" + }, { + "val" : "Wikipedia:Aortic_vestibule" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005965", "lbl" : "outflow part of right atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA].", + "xrefs" : [ "FMA:9550", "FMA:FMA" ] + }, + "xrefs" : [ { + "val" : "FMA:9550" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005966", "lbl" : "outflow part of left atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An outflow tract of atrium that is part of a left atrium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:9551" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005979", "lbl" : "crista terminalis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium.", + "xrefs" : [ "MP:0010495" ] + }, + "xrefs" : [ { + "val" : "FMA:9236" + }, { + "val" : "SCTID:277693004" + }, { + "val" : "Wikipedia:Crista_terminalis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005983", "lbl" : "heart layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The laminar structure of the heart.", + "xrefs" : [ "MP:0010545" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005985", "lbl" : "coronary vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation.", + "xrefs" : [ "MP:0010551" ] + }, + "xrefs" : [ { + "val" : "MESH:D003331" + }, { + "val" : "Wikipedia:Coronary_circulation" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "lbl" : "atrium myocardial trabecula", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The supporting bundles of muscular fibers lining the walls of the atrial myocardium.", + "xrefs" : [ "MP:0010581", "ZFA:0005810" ] + }, + "xrefs" : [ { + "val" : "ZFA:0005810" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005989", "lbl" : "atrioventricular septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve.", + "xrefs" : [ "MP:0010592" ] + }, + "xrefs" : [ { + "val" : "FMA:7136" + }, { + "val" : "SCTID:280151006" + }, { + "val" : "Wikipedia:Atrioventricular_septum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006002", "lbl" : "vitelline artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The paired arteries that carry blood to the yolk sac from the dorsal aorta.", + "xrefs" : [ "MP:0010664", "Wikipedia:Vitelline_arteries" ] + }, + "comments" : [ "Development notes:; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult[MP:0010664]" ], + "xrefs" : [ { + "val" : "EHDAA2:0002208" + }, { + "val" : "EMAPA:16207" + }, { + "val" : "Wikipedia:Vitelline_arteries" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006003", "lbl" : "integumentary adnexa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers.", + "xrefs" : [ "http://code.google.com/p/caro2/issues/detail?id=5", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Skin_appendage" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006056", "lbl" : "posterior surface of head", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006068", + "lbl" : "bone of tail", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a post-anal tail.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18042" + }, { + "val" : "MA:0000696" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006071", + "lbl" : "caudal region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "XAO:0000087" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "lbl" : "cervical region of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "That portion of the spine comprising the cervical vertebrae. The neck area of the spine.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/" ] + }, + "xrefs" : [ { + "val" : "AAO:0000092" + }, { + "val" : "BTO:0004148" + }, { + "val" : "EHDAA2:0000238" + }, { + "val" : "EHDAA:5051" + }, { + "val" : "EMAPA:17215" + }, { + "val" : "FMA:24138" + }, { + "val" : "MA:0003154" + }, { + "val" : "NCIT:C69313" + }, { + "val" : "SCTID:260488005" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "lbl" : "thoracic region of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "That part of the spine comprising the thoracic vertebrae.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/" ] + }, + "xrefs" : [ { + "val" : "BTO:0004150" + }, { + "val" : "EHDAA:5063" + }, { + "val" : "EMAPA:17396" + }, { + "val" : "FMA:9140" + }, { + "val" : "MA:0003155" + }, { + "val" : "NCIT:C69315" + }, { + "val" : "SCTID:243931006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "lbl" : "caudal region of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae.", + "xrefs" : [ "UBERONREF:0000006" ] + }, + "xrefs" : [ { + "val" : "AAO:0000082" + }, { + "val" : "EMAPA:18043" + }, { + "val" : "MA:0003158" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "lbl" : "subdivision of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of all skeletal elements in some subdivision of the vertebral column.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:16201" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006207", "lbl" : "aortico-pulmonary spiral septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions.", + "xrefs" : [ "MP:0010650", "Wikipedia:Aorticopulmonary_septum" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2409" + }, { + "val" : "EHDAA2:0000136" + }, { + "val" : "EHDAA:2592" + }, { + "val" : "EMAPA:16827" + }, { + "val" : "VHOG:0000502" + }, { + "val" : "Wikipedia:Aorticopulmonary_septum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006211", "lbl" : "buccopharyngeal membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx.", + "xrefs" : [ "MP:0012521" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000189" + }, { + "val" : "EHDAA:536" + }, { + "val" : "EMAPA:16259" + }, { + "val" : "FMA:313607" + }, { + "val" : "SCTID:361412007" + }, { + "val" : "VHOG:0000380" + }, { + "val" : "Wikipedia:Buccopharyngeal_membrane" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006218", "lbl" : "common atrial chamber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA:1267" + }, { + "val" : "EMAPA:16342" + }, { + "val" : "RETIRED_EHDAA2:0000268" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "lbl" : "ethmoid bone primordium", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000456" + }, { + "val" : "EHDAA:8363" + }, { + "val" : "EMAPA:18023" + }, { + "val" : "FMA:312597" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "lbl" : "foregut-midgut junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junctions that overlaps the foregut and midgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000569" + }, { + "val" : "EHDAA:526" + }, { + "val" : "EMAPA:16363" + }, { + "val" : "VHOG:0000291" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006236", + "lbl" : "tetrapod frontal bone primordium", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000577" + }, { + "val" : "EHDAA:9540" + }, { + "val" : "EMAPA:18017" + }, { + "val" : "FMA:312589" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006238", "lbl" : "future brain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic precursor of the brain.", + "xrefs" : [ "NLX:94995" ] + }, + "xrefs" : [ { + "val" : "BAMS:Enc" + }, { + "val" : "BTO:0004726" + }, { + "val" : "EFO:0003431" + }, { + "val" : "EHDAA:300" + }, { + "val" : "EHDAA:830" + }, { + "val" : "EMAPA:16089" + }, { + "val" : "FMA:312967" + }, { + "val" : "RETIRED_EHDAA2:0000591" + }, { + "val" : "TAO:0000146" + }, { + "val" : "ZFA:0000146" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006239", "lbl" : "future central tendon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tendon that has the potential to develop into a central tendon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000593" + }, { + "val" : "EHDAA:4118" + }, { + "val" : "EMAPA:25035" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006241", "lbl" : "future spinal cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EFO:0003438" + }, { + "val" : "EHDAA2:0000674" + }, { + "val" : "EHDAA:898" + }, { + "val" : "EMAPA:16092" + }, { + "val" : "EMAPA:16755" + }, { + "val" : "TAO:0000417" + }, { + "val" : "ZFA:0000417" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "lbl" : "gallbladder primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops.", + "xrefs" : [ "ISBN:0815318960", "XAO:0004205" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000700" + }, { + "val" : "EHDAA:3047" + }, { + "val" : "EMAPA:16713" + }, { + "val" : "XAO:0004205" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006264", "lbl" : "mouth-foregut junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junctions that overlaps the mouth and foregut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:534" + }, { + "val" : "EMAPA:16258" + }, { + "val" : "RETIRED_EHDAA2:0001205" + }, { + "val" : "VHOG:0000592" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006267", "lbl" : "notochordal plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.", + "xrefs" : [ "VHOG:0001212" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001278" + }, { + "val" : "EHDAA:264" + }, { + "val" : "EMAPA:16101" + }, { + "val" : "NCIT:C34231" + }, { + "val" : "VHOG:0001212" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006268", "lbl" : "notochordal process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.", + "xrefs" : [ "http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/05embryonicperiod.htm" ] + }, + "comments" : [ "The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus." ], + "xrefs" : [ { + "val" : "EHDAA2:0001279" + }, { + "val" : "EHDAA:224" + }, { + "val" : "EMAPA:16102" + }, { + "val" : "FMA:293135" + }, { + "val" : "NCIT:C34232" + }, { + "val" : "VHOG:0001213" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006271", + "lbl" : "orbital fissure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Either of two openings transmitting nerves and blood vessels to or from the orbit.", + "xrefs" : [ "http://www.merriam-webster.com/medical/orbital%20fissure" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001328" + }, { + "val" : "EHDAA:10648" + }, { + "val" : "EMAPA:18717" + }, { + "val" : "SCTID:280546005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006279", "lbl" : "pleuroperitoneal canal", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity.", + "xrefs" : [ "ISBN:0124020607", "VHOG:0001505" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001481" + }, { + "val" : "EHDAA:4128" + }, { + "val" : "EMAPA:17707" + }, { + "val" : "SCTID:361413002" + }, { + "val" : "VHOG:0001505" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006283", "lbl" : "future cardiac ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle.", + "xrefs" : [ "ZFA:0001719" ] + }, + "comments" : [ "The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum[WP]" ], + "xrefs" : [ { + "val" : "EHDAA2:0001531" + }, { + "val" : "EMAPA:16350" + }, { + "val" : "FMA:71006" + }, { + "val" : "NCIT:C34160" + }, { + "val" : "SCTID:361524003" + }, { + "val" : "TAO:0002231" + }, { + "val" : "Wikipedia:Embryonic_ventricle" + }, { + "val" : "ZFA:0001719" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "lbl" : "spleen primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP].", + "xrefs" : [ "ISBN:0123747295", "MP:0011263" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001904" + }, { + "val" : "EHDAA:3003" + }, { + "val" : "EMAPA:18535" + }, { + "val" : "XAO:0000326" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006304", "lbl" : "future trigeminal ganglion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/13 and https://github.com/obophenotype/uberon/issues/693 -- consider merging into trigeminal ganglion, as this complicates the model" ], + "xrefs" : [ { + "val" : "EHDAA:924" + }, { + "val" : "EMAPA:16663" + }, { + "val" : "RETIRED_EHDAA2:0002089" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006311", "lbl" : "chamber of eyeball", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A segment of the eyeball that is filled with refractive media.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0002085" + }, { + "val" : "FMA:58071" + }, { + "val" : "MA:0002459" + }, { + "val" : "NCIT:C32301" + }, { + "val" : "SCTID:280540004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006312", "lbl" : "ocular refractive media", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Body substance in a liquid or semi-solid state in the eyeball which serves to refract light.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0001911" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006314", "lbl" : "bodily fluid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.", + "xrefs" : [ "MESH:A12.207", "Wikipedia:Body_fluid" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:20" + }, { + "val" : "FMA:280556" + }, { + "val" : "GAID:266" + }, { + "val" : "MESH:D001826" + }, { + "val" : "Wikipedia:Body_fluid" + }, { + "val" : "galen:BodyFluid" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006331", "lbl" : "brainstem nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nucleus of brain that is part of a brainstem.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32790" + }, { + "val" : "MA:0000821" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006347", "lbl" : "communicating artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that connects two larger arteries.", + "xrefs" : [ "ncithesaurus:Communicating_Artery" ] + }, + "comments" : [ "Grouping for anterior and posterior" ], + "xrefs" : [ { + "val" : "EMAPA:18598" + }, { + "val" : "MA:0001938" + }, { + "val" : "NCIT:C52851" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006518", "lbl" : "right lung lobe", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lobe of lung that is part of a right lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35155" + }, { + "val" : "MA:0001791" + }, { + "val" : "NCIT:C48944" + }, { + "val" : "SCTID:272654004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006524", "lbl" : "alveolar system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "System pertaining to a bronchus and alveoli.", + "xrefs" : [ "BTO:0000136" ] + }, + "xrefs" : [ { + "val" : "BTO:0000136" + }, { + "val" : "CALOHA:TS-1296" + }, { + "val" : "EMAPA:32692" + }, { + "val" : "MA:0000416" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006525", "lbl" : "left lung alveolar system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:19001" + }, { + "val" : "MA:0001775" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006526", "lbl" : "right lung alveolar system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:35717" + }, { + "val" : "MA:0001784" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006535", "lbl" : "skin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of organism substance that secreted_by a zone of skin.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002537" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006537", "lbl" : "female reproductive gland secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of organism substance that is secreted by a female reproductive gland.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "MA:0002510" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006538", "lbl" : "respiratory system fluid/secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of organism substance that secreted_by a respiratory system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36550" + }, { + "val" : "MA:0002533" + }, { + "val" : "NCIT:C13722" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006555", + "lbl" : "excretory tube", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tube that is part of a excretory system.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006562", "lbl" : "pharynx", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pharynx is the part of the digestive system immediately posterior to the mouth[GO].", + "xrefs" : [ "GO:0060465" ] + }, + "xrefs" : [ { + "val" : "MAT:0000049" + }, { + "val" : "MESH:D010614" + }, { + "val" : "MIAA:0000049" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006563", "lbl" : "tunica media of pulmonary trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA].", + "xrefs" : [ "FMA:85030", "FMA:FMA" ] + }, + "xrefs" : [ { + "val" : "FMA:85030" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006566", "lbl" : "left ventricle myocardium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A myocardium that is part of a left ventricle of a heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:9558" + }, { + "val" : "MA:0002983" + }, { + "val" : "SCTID:362021000" } ] } }, { @@ -21211,577 +74511,2732 @@ "lbl" : "right ventricle myocardium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A myocardium that is part of a right ventricle of a heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:9535" + }, { + "val" : "MA:0002984" + }, { + "val" : "SCTID:362020004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006570", + "lbl" : "trabecula carnea of right ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A trabecula carnea that is part of a heart right ventricle.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7270" + }, { + "val" : "SCTID:192373001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006571", + "lbl" : "trabecula carnea of left ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A trabecula carnea that is part of a heart left ventricle.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7271" + }, { + "val" : "SCTID:190344008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "lbl" : "pectinate line", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:.", + "xrefs" : [ "Wikipedia:Pectinate_line" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19159" + }, { + "val" : "FMA:75383" + }, { + "val" : "NCIT:C34245" + }, { + "val" : "SCTID:245445008" + }, { + "val" : "Wikipedia:Pectinate_line" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006595", "lbl" : "presumptive endoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Presumptive structure of the blastula that will develop into endoderm.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000471" + }, { + "val" : "EFO:0003437" + }, { + "val" : "TAO:0000416" + }, { + "val" : "ZFA:0000416" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006596", "lbl" : "presumptive blood", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "AAO:0000468" + }, { + "val" : "EFO:0003439" + }, { + "val" : "TAO:0000568" + }, { + "val" : "ZFA:0000568" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006598", "lbl" : "presumptive structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of embryonic tissue determined by fate mapping to become a structure.", + "xrefs" : [ "GOC:CVS", "GOC:YMB", "ZFA:0001116" ] + }, + "xrefs" : [ { + "val" : "AAO:0000479" + }, { + "val" : "TAO:0001116" + }, { + "val" : "ZFA:0001116" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006601", "lbl" : "presumptive ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Presumptive structure of the blastula that will develop into ectoderm.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000470" + }, { + "val" : "EFO:0003466" + }, { + "val" : "TAO:0001376" + }, { + "val" : "XAO:0004132" + }, { + "val" : "ZFA:0001376" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006603", "lbl" : "presumptive mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Presumptive structure of the blastula that will develop into mesoderm.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000476" + }, { + "val" : "EFO:0003467" + }, { + "val" : "TAO:0001377" + }, { + "val" : "ZFA:0001377" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006660", + "lbl" : "muscular coat", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis.", + "xrefs" : [ "Wikipedia:Muscular_layer" ] + }, + "xrefs" : [ { + "val" : "BTO:0004838" + }, { + "val" : "SCTID:86915006" + }, { + "val" : "Wikipedia:Muscular_layer" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006670", "lbl" : "central tendon of diaphragm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers.", + "xrefs" : [ "MGI:csmith", "MP:0012061" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17702" + }, { + "val" : "FMA:58279" + }, { + "val" : "NCIT:C34119" + }, { + "val" : "SCTID:244943002" + }, { + "val" : "VHOG:0001399" + }, { + "val" : "Wikipedia:Central_tendon_of_diaphragm" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006677", "lbl" : "surface of epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical boundary that adjacent_to a epithelium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:70997" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006686", + "lbl" : "spinal vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a vertebral column.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18255" + }, { + "val" : "FMA:76735" + }, { + "val" : "MA:0002108" + }, { + "val" : "SCTID:181376008" + }, { + "val" : "Wikipedia:Spinal_veins" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006761", "lbl" : "corneo-scleral junction", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm.", + "xrefs" : [ "MP:0013477" ] + }, + "comments" : [ "This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343" ], + "xrefs" : [ { + "val" : "EFO:0001403" + }, { + "val" : "FMA:58342" + }, { + "val" : "GAID:896" + }, { + "val" : "MESH:D016850" + }, { + "val" : "SCTID:63716004" + }, { + "val" : "Wikipedia:Corneal_limbus" + }, { + "val" : "ZFA:0005570" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006799", "lbl" : "glandular epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is composed primarily of secretory cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0002991" + }, { + "val" : "NCIT:C43370" + }, { + "val" : "NCIT:C45715" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006815", "lbl" : "areolar connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand.", + "xrefs" : [ "FMA:63897" ] + }, + "xrefs" : [ { + "val" : "AAO:0000027" + }, { + "val" : "FMA:63897" + }, { + "val" : "SCTID:68477002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006828", + "lbl" : "trabecula carnea of atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The supporting bundles of muscular fibers lining the walls of the atria[MP].", + "xrefs" : [ "MP:0010581" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006833", "lbl" : "lumen of trachea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that surrounded_by a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7469" + }, { + "val" : "SCTID:197486000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006834", "lbl" : "uterus or analog", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of a the reproductive tract in a female organism that is the site of embryo development.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TADS:0000421" + }, { + "val" : "WBbt:0006760" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006841", + "lbl" : "central vein of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vein that is central to a lobule in the liver.", + "xrefs" : [ "ZFA:0005168" ] + }, + "xrefs" : [ { + "val" : "FMA:17544" + }, { + "val" : "NCIT:C32281" + }, { + "val" : "SCTID:272023004" + }, { + "val" : "TAO:0005168" + }, { + "val" : "Wikipedia:Central_veins_of_liver" + }, { + "val" : "ZFA:0005168" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006846", "lbl" : "surface groove", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A furrow or an incomplete tube.", + "xrefs" : [ "AEO:0000161", "AEO:JB", "https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/4" ] + }, + "comments" : [ "Surface groove is modelled as immaterial - see https://github.com/obophenotype/uberon/issues/2667 for discussion" ], + "xrefs" : [ { + "val" : "AEO:0000161" + }, { + "val" : "EHDAA2_RETIRED:0003161" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006866", + "lbl" : "terminal part of digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "WBbt:0005773" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006876", "lbl" : "vasculature of organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a organ.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:74612" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006877", + "lbl" : "vasculature of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0003454" + }, { + "val" : "EMAPA:35501" + }, { + "val" : "FMA:73748" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006904", "lbl" : "head mesenchyme from mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A head mesenchyme that develops_from a mesoderm.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0011051" + }, { + "val" : "EFO:0003337" + }, { + "val" : "EFO:0003603" + }, { + "val" : "EHDAA2:0001118" + }, { + "val" : "EHDAA:655" + }, { + "val" : "EMAPA:16099" + }, { + "val" : "EMAPA_RETIRED:16270" + }, { + "val" : "FMA:293859" + }, { + "val" : "TAO:0000998" + }, { + "val" : "VHOG:0000185" + }, { + "val" : "XAO:0000053" + }, { + "val" : "ZFA:0000998" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006905", "lbl" : "mandibular process mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a mandibular prominence.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001062" + }, { + "val" : "EHDAA:5861" + }, { + "val" : "EHDAA:5873" + }, { + "val" : "EMAPA:17357" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006909", "lbl" : "lumen of digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that surrounded_by a digestive tract.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000349" + }, { + "val" : "EMAPA:32908" + }, { + "val" : "FMA:45677" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006913", "lbl" : "lip epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a lip.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004468" + }, { + "val" : "TAO:0005334" + }, { + "val" : "ZFA:0005334" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006914", "lbl" : "squamous epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium characterised by its most superficial layer consisting of squamous epithelial cells.", + "xrefs" : [ "Wikipedia:Squamous_epithelium" ] + }, + "xrefs" : [ { + "val" : "BTO:0002072" + }, { + "val" : "NCIT:C12848" + }, { + "val" : "SCTID:40118003" + }, { + "val" : "Wikipedia:Squamous_epithelium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006915", "lbl" : "stratified squamous epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA].", + "xrefs" : [ "FMA:45563", "Wikipedia:Stratified_squamous_epithelium" ] + }, + "xrefs" : [ { + "val" : "FMA:45563" + }, { + "val" : "NCIT:C13180" + }, { + "val" : "Wikipedia:Stratified_squamous_epithelium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006920", "lbl" : "esophagus squamous epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A squamous epithelium that is part of a esophagus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0003635" + }, { + "val" : "CALOHA:TS-1250" + }, { + "val" : "EMAPA:35324" + }, { + "val" : "MA:0001567" + }, { + "val" : "NCIT:C49222" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006921", "lbl" : "stomach squamous epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A squamous epithelium that is part of a stomach.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35824" + }, { + "val" : "MA:0001611" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006924", "lbl" : "stomach glandular epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands.", + "xrefs" : [ "ISBN:0073040584" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35814" + }, { + "val" : "FMA:63458" + }, { + "val" : "MA:0002784" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006925", "lbl" : "digestive system gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any gland that is part of the digestive system.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "AAO:0000130" + }, { + "val" : "BTO:0000345" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006929", "lbl" : "glandular columnar epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA].", + "xrefs" : [ "FMA:64800" ] + }, + "xrefs" : [ { + "val" : "FMA:64800" + }, { + "val" : "NCIT:C13182" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006930", "lbl" : "glandular cuboidal epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:66809" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006931", "lbl" : "stomach glandular region mucosa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27167" + }, { + "val" : "MA:0001614" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006934", "lbl" : "sensory epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue.", + "xrefs" : [ "BTO:0000314" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0682" + }, { + "val" : "FMA:62410" + }, { + "val" : "SCTID:309045006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006960", "lbl" : "ovary stroma", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis.", + "xrefs" : [ "Wikipedia:Stroma_of_ovary" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1246" + }, { + "val" : "EMAPA:28880" + }, { + "val" : "FMA:18626" + }, { + "val" : "MA:0002991" + }, { + "val" : "NCIT:C33638" + }, { + "val" : "SCTID:259306002" + }, { + "val" : "Wikipedia:Stroma_of_ovary" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006965", "lbl" : "vascular cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA].", + "xrefs" : [ "GO:0072360", "ZFA:0005077" ] + }, + "xrefs" : [ { + "val" : "EFO:0003709" + }, { + "val" : "TAO:0005077" + }, { + "val" : "ZFA:0005077" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006966", "lbl" : "coronary capillary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of the coronary system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "ZFA:0005813" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006984", "lbl" : "anatomical surface", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n.", + "xrefs" : [ "CARO:0001002" ] + }, + "comments" : [ "Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism." ], + "xrefs" : [ { + "val" : "BILA:0000010" + }, { + "val" : "CARO:0001002" + }, { + "val" : "EHDAA2_RETIRED:0003192" + }, { + "val" : "FMA:24137" + }, { + "val" : "NCIT:C34022" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007005", "lbl" : "cardiogenic splanchnic mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO].", + "xrefs" : [ "XAO:0000235", "http://www.drugs.com/dict/cardiogenic-mesoderm.html", "https://github.com/obophenotype/insect_neuroanatomy_ontology/issues/7" ] + }, + "xrefs" : [ { + "val" : "AAO:0011021" + }, { + "val" : "BILA:0000051" + }, { + "val" : "EFO:0000315" + }, { + "val" : "EHDAA2:0000214" + }, { + "val" : "EHDAA:385" + }, { + "val" : "FMA:293143" + }, { + "val" : "SCTID:360387000" + }, { + "val" : "VHOG:0001641" + }, { + "val" : "XAO:0000235" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007010", "lbl" : "cleaving embryo", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organism at the cleavage stage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BILA:0000058" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007026", "lbl" : "presumptive gut", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BILA:0000084" + }, { + "val" : "NCIT:C34268" + }, { + "val" : "SCTID:360394002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007037", "lbl" : "mechanosensory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BILA:0000142" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007098", "lbl" : "mandibular neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cranial neural crest that migrates into the mandibular arch.", + "xrefs" : [ "ZFA:0007064" ] + }, + "xrefs" : [ { + "val" : "TAO:0007064" + }, { + "val" : "XAO:0000024" + }, { + "val" : "ZFA:0007064" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007100", "lbl" : "primary circulatory organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].", + "xrefs" : [ "GO:0007507" ] + }, + "comments" : [ "Gene notes: Bmp, Nkx, Gata" ], + "xrefs" : [ { + "val" : "TADS:0000147" + }, { + "val" : "http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007134", "lbl" : "trunk ganglion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ganglion which is located in the trunk.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EFO:0000901" + }, { + "val" : "MAT:0000344" + }, { + "val" : "MIAA:0000344" + }, { + "val" : "TAO:0001573" + }, { + "val" : "ZFA:0001573" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007135", "lbl" : "neural keel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section.", + "xrefs" : [ "ZFIN:ZDB-PUB-961014-576" ] + }, + "xrefs" : [ { + "val" : "EFO:0003497" + }, { + "val" : "TAO:0000131" + }, { + "val" : "ZFA:0000131" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007144", + "lbl" : "embryonic post-anal tail", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16748" + }, { + "val" : "FMA:85540" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007147", + "lbl" : "lumen of midgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a midgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18377" + }, { + "val" : "FMA:54366" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007148", + "lbl" : "lumen of hindgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a hindgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18396" + }, { + "val" : "FMA:54367" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007158", + "lbl" : "lumen of anal canal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a anal canal.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18836" + }, { + "val" : "FMA:17357" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007159", + "lbl" : "lumen of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a colon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18945" + }, { + "val" : "FMA:18374" + }, { + "val" : "SCTID:362156004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007177", + "lbl" : "lamina propria of mucosa of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a colonic mucosa.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27395" + }, { + "val" : "FMA:15657" + }, { + "val" : "MA:0003196" + }, { + "val" : "SCTID:113284008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007188", "lbl" : "mesothelium of serous pericardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelium that is part of a serous pericardium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0003157" + }, { + "val" : "EMAPA:16133" + }, { + "val" : "FMA:18149" + }, { + "val" : "SCTID:67300002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007195", "lbl" : "stroma of bone marrow", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis.", + "xrefs" : [ "Wikipedia:Bone_marrow#Stroma" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0085" + }, { + "val" : "FMA:21426" + }, { + "val" : "Wikipedia:Bone_marrow#Stroma" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007196", "lbl" : "tracheobronchial tree", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells.", + "xrefs" : [ "Wikipedia:Tracheobronchial_tree" ] + }, + "xrefs" : [ { + "val" : "FMA:7393" + }, { + "val" : "NCIT:C117875" + }, { + "val" : "SCTID:361384001" + }, { + "val" : "Wikipedia:Tracheobronchial_tree" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007204", "lbl" : "brachiocephalic vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The vasculature consisting of brachiocephalic arteries and veins.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007213", "lbl" : "mesenchyme derived from head neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a cranial neural crest.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003572" + }, { + "val" : "EHDAA2:0000735" + }, { + "val" : "EMAPA:16169" + }, { + "val" : "EMAPA:16271" + }, { + "val" : "EMAPA_RETIRED:16271" + }, { + "val" : "TAO:0000787" + }, { + "val" : "ZFA:0000787" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007214", "lbl" : "mesenchyme derived from trunk neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a trunk neural crest.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002093" + }, { + "val" : "EMAPA:16182" + }, { + "val" : "TAO:0000999" + }, { + "val" : "ZFA:0000999" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007237", "lbl" : "1st arch mandibular component", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000031" + }, { + "val" : "EHDAA:583" + }, { + "val" : "EMAPA:16382" + }, { + "val" : "VHOG:0000510" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007238", + "lbl" : "1st arch maxillary component", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000038" + }, { + "val" : "EHDAA:595" + }, { + "val" : "EMAPA:16388" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007239", "lbl" : "tunica media of artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica media that is part of a artery.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36294" + }, { + "val" : "EV:0100029" + }, { + "val" : "FMA:14273" + }, { + "val" : "NCIT:C49321" + }, { + "val" : "SCTID:84300001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007240", "lbl" : "tunica adventitia of artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica adventitia that is part of a artery.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36295" + }, { + "val" : "EV:0100030" + }, { + "val" : "FMA:14274" + }, { + "val" : "SCTID:113261001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007241", "lbl" : "tunica adventitia of vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica adventitia that is part of a vein.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36310" + }, { + "val" : "EV:0100034" + }, { + "val" : "FMA:14355" + }, { + "val" : "SCTID:13202006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007242", "lbl" : "tunica intima of vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica intima that is part of a vein.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36308" + }, { + "val" : "EV:0100032" + }, { + "val" : "FMA:14353" + }, { + "val" : "SCTID:2436009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007243", "lbl" : "tunica media of vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica media that is part of a vein.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36309" + }, { + "val" : "EV:0100033" + }, { + "val" : "FMA:14354" + }, { + "val" : "SCTID:42049001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007245", "lbl" : "nuclear complex of neuraxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Gray matter of the central nervous system which is a collection of clustered nuclei.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:256381" + }, { + "val" : "FMA:84059" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007247", "lbl" : "nucleus of superior olivary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:72246" + }, { + "val" : "SCTID:369024009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007267", "lbl" : "trachea pre-cartilage rings", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pre-cartilage condensation that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002070" + }, { + "val" : "EHDAA:7082" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007269", "lbl" : "pectoral appendage musculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a pectoral appendage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003540" + }, { + "val" : "TAO:0000563" + }, { + "val" : "ZFA:0000563" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007271", "lbl" : "appendage musculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of an appendage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0000207" + }, { + "val" : "ZFA:0000207" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007272", "lbl" : "pectoral appendage skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle.", + "xrefs" : [ "VSAO:0005000", "VSAO:NI" ] + }, + "xrefs" : [ { + "val" : "VSAO:0005000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007277", "lbl" : "presumptive hindbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure.", + "xrefs" : [ "Wikipedia:Rhombencephalon" ] + }, + "xrefs" : [ { + "val" : "BAMS:HB" + }, { + "val" : "CALOHA:TS-2118" + }, { + "val" : "EFO:0003440" + }, { + "val" : "EHDAA2:0001630" + }, { + "val" : "FMA:295640" + }, { + "val" : "TAO:0000569" + }, { + "val" : "Wikipedia:Rhombencephalon" + }, { + "val" : "ZFA:0000569" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007278", "lbl" : "presumptive sinus venosus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that is part of the heart tube and will become the sinus venosus.", + "xrefs" : [ "ZFA:0001722" ] + }, + "xrefs" : [ { + "val" : "TAO:0002234" + }, { + "val" : "ZFA:0001722" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007280", "lbl" : "presumptive endocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A presumptive structure that has the potential to develop into a endocardium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0002233" + }, { + "val" : "ZFA:0001724" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007281", "lbl" : "presumptive midbrain hindbrain boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Embryonic structure that gives rise to the midbrain hindbrain boundary.", + "xrefs" : [ "ZFA:0001187" ] + }, + "xrefs" : [ { + "val" : "EFO:0003446" + }, { + "val" : "TAO:0001187" + }, { + "val" : "XAO:0004086" + }, { + "val" : "ZFA:0001187" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007282", "lbl" : "presumptive segmental plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A presumptive structure that has the potential to develop into a presomitic mesoderm.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003421" + }, { + "val" : "TAO:0000053" + }, { + "val" : "ZFA:0000053" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007284", "lbl" : "presumptive neural plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A presumptive structure that has the potential to develop into a neural plate.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003424" + }, { + "val" : "TAO:0000063" + }, { + "val" : "ZFA:0000063" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007285", "lbl" : "presumptive paraxial mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the blastula that has the potential to develop into a paraxial mesoderm.", + "xrefs" : [ "UBERON:cjm", "https://github.com/obophenotype/uberon/issues/1277" ] + }, + "xrefs" : [ { + "val" : "EFO:0003443" + }, { + "val" : "TAO:0000591" + }, { + "val" : "XAO:0004134" + }, { + "val" : "ZFA:0000591" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007300", "lbl" : "pectoral appendage blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a pectoral appendage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005301" + }, { + "val" : "ZFA:0005301" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007301", "lbl" : "appendage blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a limb/fin.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005299" + }, { + "val" : "ZFA:0005299" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007302", "lbl" : "pectoral appendage vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a pectoral appendage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005096" + }, { + "val" : "ZFA:0005096" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007303", "lbl" : "pharyngeal vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a chordate pharynx.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005003" + }, { + "val" : "ZFA:0005003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007304", "lbl" : "appendage vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a limb/fin.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005095" + }, { + "val" : "ZFA:0005095" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "lbl" : "pancreatic lobule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans.", + "xrefs" : [ "ISBN:0123813611" ] + }, + "xrefs" : [ { + "val" : "FMA:16012" + }, { + "val" : "MA:0000721" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "lbl" : "pancreatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A duct that collects and carries secretions of the exocrine pancreas to the intestine.", + "xrefs" : [ "GOC:cvs", "GOC:ymb", "Wikipedia:Pancreatic_duct", "https://github.com/obophenotype/uberon/issues/1250", "https://orcid.org/0000-0002-2244-7917", "https://orcid.org/0000-0002-6601-2165", "https://orcid.org/0000-0002-9900-7880" ] + }, + "xrefs" : [ { + "val" : "EHDAA:9194" + }, { + "val" : "EMAPA:32952" + }, { + "val" : "FMA:10419" + }, { + "val" : "MA:0000124" + }, { + "val" : "SCTID:181278006" + }, { + "val" : "TAO:0001372" + }, { + "val" : "VHOG:0000254" + }, { + "val" : "Wikipedia:Pancreatic_duct" + }, { + "val" : "ZFA:0001372" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007375", + "lbl" : "roof of mouth", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2212" + }, { + "val" : "Wikipedia:Palate" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007376", "lbl" : "outer epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO].", + "xrefs" : [ "GO:0008544" ] + }, + "xrefs" : [ { + "val" : "BSA:0000073" + }, { + "val" : "BTO:0000313" + }, { + "val" : "HAO:0000298" + }, { + "val" : "TADS:0000109" + }, { + "val" : "WBbt:0005733" + }, { + "val" : "Wikipedia:Epidermis_(zoology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007383", "lbl" : "enveloping layer of ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Outermost layer of cells surrounding the embryo.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EFO:0003425" + }, { + "val" : "TAO:0000086" + }, { + "val" : "ZFA:0000086" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007389", "lbl" : "paired limb/fin cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage tissue that is part of a paired limb or fin.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001543" + }, { + "val" : "ZFA:0001543" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007390", "lbl" : "pectoral appendage cartilage tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage tissue that is part of a pectoral appendage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0000257" + }, { + "val" : "ZFA:0000257" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007414", "lbl" : "nucleus of midbrain tegmentum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nucleus of brain that spans a midbrain tegmentum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:258768" + }, { + "val" : "ZFA:0005577" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007473", "lbl" : "lumen of epithelial sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The space within an epithelial sphere.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000079" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007475", "lbl" : "matrix-based tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000081" + }, { + "val" : "EHDAA2:0003081" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007499", "lbl" : "epithelial sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial tube that is open at one end only.", + "xrefs" : [ "AEO:JB", "UBERONREF:0000001" ] + }, + "xrefs" : [ { + "val" : "AEO:0000115" + }, { + "val" : "EHDAA2:0003115" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007500", "lbl" : "epithelial tube open at both ends", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial tube open at both ends that allows fluid flow.", + "xrefs" : [ "AEO:JB", "UBERONREF:0000001" ] + }, + "xrefs" : [ { + "val" : "AEO_RETIRED:0000116" + }, { + "val" : "RETIRED_EHDAA2:0003116" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007503", "lbl" : "epithelial vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A closed epithelium with a lumen.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000119" + }, { + "val" : "EHDAA2:0003119" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007521", + "lbl" : "smooth muscle sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ring of smooth muscle cells whose contraction closes the opening of the ring.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000143" + }, { + "val" : "EHDAA2:0003143" + }, { + "val" : "SCTID:362915001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007522", + "lbl" : "striated muscle sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ring of striated muscle cells whose contraction closes the opening of the ring.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000144" + }, { + "val" : "EHDAA2:0003144" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007524", "lbl" : "dense mesenchyme tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme with little extracellular matrix.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000146" + }, { + "val" : "EHDAA2:0003146" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007530", "lbl" : "migrating mesenchyme population", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchymal cells that are migrating.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000152" + }, { + "val" : "EHDAA2:0003152" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007592", "lbl" : "ciliated columnar epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA].", + "xrefs" : [ "FMA:64798" ] + }, + "xrefs" : [ { + "val" : "FMA:64798" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007601", "lbl" : "ciliated epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium bearing vibratile cilia on the free surface.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/ciliated+epithelium" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007616", "lbl" : "layer of synovial tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO].", + "xrefs" : [ "BTO:0001338", "http://www.britannica.com/EBchecked/topic/578563/synovial-tissue" ] + }, + "xrefs" : [ { + "val" : "BTO:0001338" + }, { + "val" : "CALOHA:TS-0998" + }, { + "val" : "FMA:66762" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007617", "lbl" : "synovial cavity of joint", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a synovial joint.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:11356" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007625", "lbl" : "pigment epithelium of eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules.", + "xrefs" : [ "MP:0005200" ] + }, + "xrefs" : [ { + "val" : "GAID:907" + }, { + "val" : "MESH:D010857" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007635", "lbl" : "nucleus of medulla oblongata", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural nucleus that is part of a medulla oblongata.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:258772" + }, { + "val" : "SCTID:304943004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007641", "lbl" : "trigeminal nuclear complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP].", + "xrefs" : [ "Wikipedia:Trigeminal_nerve_nuclei" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:4096" + }, { + "val" : "BM:V" + }, { + "val" : "CALOHA:TS-2077" + }, { + "val" : "DHBA:266441713" + }, { + "val" : "FMA:71248" + }, { + "val" : "HBA:9203" + }, { + "val" : "Wikipedia:Trigeminal_nerve_nuclei" + }, { + "val" : "neuronames:2021" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007651", "lbl" : "anatomical junction", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "definition" : { + "val" : "An anatomical structure that connects two structures.", + "xrefs" : [ "http://code.google.com/p/caro2/issues/detail?id=15" ] + }, + "xrefs" : [ { + "val" : "FMA:5898" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "SCTID:91833003" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007652", + "lbl" : "esophageal sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphincter that is part of an esophagus.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "SCTID:277765007" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007688", "lbl" : "anlage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue.", + "xrefs" : [ "FBbt:00005426", "http://flybase.org/reports/FBrf0178740.html" ] + }, + "xrefs" : [ { + "val" : "AEO:0000170" + }, { + "val" : "EFO:0001649" + }, { + "val" : "EHDAA2:0003170" + }, { + "val" : "Wikipedia:Anlage_(biology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007690", "lbl" : "early pharyngeal endoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "relation conflict: ZFA vs EHDAA2. Note EHDAA2 term renamed to 'early PA endoderm'" ], + "xrefs" : [ { + "val" : "EFO:0003626" + }, { + "val" : "EHDAA2:0001457" + }, { + "val" : "EHDAA:962" + }, { + "val" : "TAO:0001104" + }, { + "val" : "ZFA:0001104" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007719", "lbl" : "bone of reproductive organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a reproductive organ.", + "xrefs" : [ "OBOL:automatic", "https://github.com/obophenotype/uberon/issues/1158" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007771", "lbl" : "epidermis gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a epidermis.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:59153" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007779", "lbl" : "transudate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/transudate" ] + }, + "xrefs" : [ { + "val" : "FMA:12276" + }, { + "val" : "GAID:1195" + }, { + "val" : "MESH:D005122" + }, { + "val" : "ncithesaurus:Transudate" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007794", "lbl" : "secretion of serous gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fluid produced by a serous gland.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Serous_fluid" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007798", "lbl" : "vascular system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical system that consists of all blood and lymph vessels.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001085" + }, { + "val" : "CALOHA:TS-2053" + }, { + "val" : "EHDAA2:0004520" + }, { + "val" : "EMAPA:35905" + }, { + "val" : "MA:0002718" + }, { + "val" : "NCIT:C33854" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007808", "lbl" : "adipose tissue of abdominal region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots.", + "xrefs" : [ "CALOHA:paula", "MGI:csmith", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/259" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0002" + }, { + "val" : "EFO:0003771" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007811", "lbl" : "craniocervical region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2356" + }, { + "val" : "EV:0100009" + }, { + "val" : "FMA:280881" + }, { + "val" : "MA:0000006" + }, { + "val" : "NCIT:C12418" + }, { + "val" : "SCTID:361355005" + }, { + "val" : "WikipediaCategory:Head_and_neck" + }, { + "val" : "galen:HeadAndNeck" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "lbl" : "post-anal tail", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010338" + }, { + "val" : "MA:0000008" + }, { + "val" : "NCIT:C77663" + }, { + "val" : "TAO:0001117" + }, { + "val" : "XAO:0003026" + }, { + "val" : "ZFA:0001117" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007823", "lbl" : "appendage girdle region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).", + "xrefs" : [ "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:24874" + }, { + "val" : "VSAO:0000303" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007826", + "lbl" : "peritoneal mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesentery that is located in the peritoneum.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:20570" + }, { + "val" : "TAO:0005129" + }, { + "val" : "XAO:0000138" + }, { + "val" : "ZFA:0005129" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007828", "lbl" : "girdle bone/zone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a appendage girdle region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35379" + }, { + "val" : "MA:0000291" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007829", "lbl" : "pectoral girdle bone", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A bone that is part of a pectoral girdle region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35669" + }, { + "val" : "MA:0000292" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007831", "lbl" : "pectoral girdle skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons.", + "xrefs" : [ "Wikipedia:Pectoral_girdle" ] + }, + "xrefs" : [ { + "val" : "AAO:0000422" + }, { + "val" : "AAO:0000754" + }, { + "val" : "EFO:0000946" + }, { + "val" : "EHDAA2:0001420" + }, { + "val" : "FMA:24141" + }, { + "val" : "MAT:0000181" + }, { + "val" : "MIAA:0000181" + }, { + "val" : "NCIT:C33547" + }, { + "val" : "TAO:0000407" + }, { + "val" : "VHOG:0001156" + }, { + "val" : "VSAO:0000156" + }, { + "val" : "Wikipedia:Pectoral_girdle" + }, { + "val" : "XAO:0003063" + }, { + "val" : "ZFA:0000407" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007842", "lbl" : "membrane bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bone element that arises as a result of intramembranous ossification.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000023", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/267" ] + }, + "xrefs" : [ { + "val" : "AEO:0000085" + }, { + "val" : "EHDAA2:0003085" + }, { + "val" : "TAO:0001645" + }, { + "val" : "VSAO:0000023" + }, { + "val" : "XAO:0004014" + }, { + "val" : "ZFA:0001636" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007844", "lbl" : "cartilage element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal element that is composed of cartilage tissue and may be permanent or transient.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000000", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AAO:0011130" + }, { + "val" : "CALOHA:TS-0118" + }, { + "val" : "FMA:55107" + }, { + "val" : "VSAO:0000000" + }, { + "val" : "XAO:0004013" + }, { + "val" : "ZFA:0001501" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007845", "lbl" : "regular connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue.", + "xrefs" : [ "FMA:20103" ] + }, + "xrefs" : [ { + "val" : "FMA:20103" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007846", "lbl" : "dense regular connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000050", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "FMA:64781" + }, { + "val" : "NCIT:C33453" + }, { + "val" : "SCTID:22560007" + }, { + "val" : "VSAO:0000050" + }, { + "val" : "Wikipedia:Dense_regular_connective_tissue" + }, { + "val" : "XAO:0004030" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007914", "lbl" : "bone of craniocervical region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a craniocervical region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000569" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008001", + "lbl" : "irregular bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid.", + "xrefs" : [ "Wikipedia:Irregular_bone" ] + }, + "xrefs" : [ { + "val" : "FMA:7477" + }, { + "val" : "NCIT:C32881" + }, { + "val" : "SCTID:421560006" + }, { + "val" : "Wikipedia:Irregular_bone" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008114", "lbl" : "joint of girdle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal joint that is part of a appendage girdle region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001505" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008115", "lbl" : "surface of cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical surface that is part of a cartilage element.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:76668" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008193", + "lbl" : "pneumatized bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD].", + "xrefs" : [ "http://www.medilexicon.com/medicaldictionary.php?t=11303" ] + }, + "xrefs" : [ { + "val" : "FMA:7478" + }, { + "val" : "SCTID:333008005" + }, { + "val" : "Wikipedia:Skeletal_pneumaticity" + }, { + "val" : "galen:PneumaticBone" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008196", "lbl" : "muscle of pectoral girdle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a pectoral girdle region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:37347" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008229", "lbl" : "craniocervical region musculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Musculature system of the pharyngeal and head regions.", + "xrefs" : [ "ZFA:0000328", "ZFA:curator" ] + }, + "xrefs" : [ { + "val" : "MA:0000571" + }, { + "val" : "TAO:0000328" + }, { + "val" : "ZFA:0000328" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008231", "lbl" : "dorsal thoracic segment of trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax.", + "xrefs" : [ "FMA:24217" ] + }, + "xrefs" : [ { + "val" : "FMA:24217" + }, { + "val" : "MA:0000028" + }, { + "val" : "SCTID:362666008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008243", "lbl" : "upper back muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle of back that is part of a dorsal thoracic segment of trunk.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000508" + }, { + "val" : "SCTID:305071003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008307", "lbl" : "heart endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a heart [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004293" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008339", "lbl" : "microvascular endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0003122" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008342", + "lbl" : "intestinal villus of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An intestinal villus in the duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63300" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008346", + "lbl" : "duodenal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2087" + }, { + "val" : "EMAPA:19078" + }, { + "val" : "FMA:17231" + }, { + "val" : "MA:0003208" + }, { + "val" : "SCTID:66036002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008397", "lbl" : "tracheobronchial epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium pertaining to the trachea and bronchi.", + "xrefs" : [ "Dorlands_Medical_Dictionary:MerckMedicus" ] + }, + "xrefs" : [ { + "val" : "BTO:0002925" + }, { + "val" : "CALOHA:TS-1063" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008780", "lbl" : "inner cell mass derived epiblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers.", + "xrefs" : [ "MP:0003886" ] + }, + "comments" : [ "The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5." ], + "xrefs" : [ { + "val" : "EHDAA2:0000444" + }, { + "val" : "EHDAA:42" + }, { + "val" : "EHDAA:75" + }, { + "val" : "EMAPA:16050" + }, { + "val" : "NCIT:C34164" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008814", "lbl" : "pharyngeal arch system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified].", + "xrefs" : [ "GO:0060037", "GOC:dph" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000187" + }, { + "val" : "FMA:293041" + }, { + "val" : "NCIT:C34248" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008816", "lbl" : "embryonic head", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A head that is part of a embryo.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0246" + }, { + "val" : "FMA:293011" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008823", "lbl" : "neural tube derived brain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A brain that develops_from a neural tube.", + "xrefs" : [ "OBOL:automatic", "https://github.com/obophenotype/uberon/issues/338" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008826", "lbl" : "pulmonary surfactant", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein).", + "xrefs" : [ "Wikipedia:Pulmonary_surfactant" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36551" + }, { + "val" : "FMA:62780" + }, { + "val" : "MA:0002534" + }, { + "val" : "NCIT:C13273" + }, { + "val" : "Wikipedia:Pulmonary_surfactant" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "lbl" : "hepatic diverticulum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts.", + "xrefs" : [ "MP:MP", "http://www.stembook.org/node/512" ] + }, + "xrefs" : [ { + "val" : "AAO:0011057" + }, { + "val" : "EHDAA2:0000740" + }, { + "val" : "EHDAA:1530" + }, { + "val" : "NCIT:C34187" + }, { + "val" : "Wikipedia:Hepatic_diverticulum" + }, { + "val" : "XAO:0000101" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "lbl" : "liver bud", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0001642" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008851", "lbl" : "ectoplacental cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals.", + "xrefs" : [ "MP:0011207", "http://www.medilexicon.com/medicaldictionary.php?s=epamniotic+cavity" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16080" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "lbl" : "stomach muscularis externa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines.", + "xrefs" : [ "MP:0010779" ] + }, + "xrefs" : [ { + "val" : "FMA:14909" + }, { + "val" : "SCTID:362132003" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "lbl" : "pyloric canal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter.", + "xrefs" : [ "MP:0010791", "Wikipedia:Pyloric_canal" ] + }, + "xrefs" : [ { + "val" : "FMA:14580" + }, { + "val" : "SCTID:245417002" + }, { + "val" : "Wikipedia:Pyloric_canal" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "lbl" : "pyloric gastric gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP].", + "xrefs" : [ "MP:0010797", "Wikipedia:Pyloric_gland" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27211" + }, { + "val" : "FMA:14922" + }, { + "val" : "NCIT:C33431" + }, { + "val" : "SCTID:70710007" + }, { + "val" : "Wikipedia:Pyloric_gland" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008870", "lbl" : "pulmonary alveolar parenchyma", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages.", + "xrefs" : [ "MP:0010901" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008874", "lbl" : "pulmonary acinus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The largest lung subunit in which all airways participate in gas exchange, and it is composed of the parenchyma of the respiratory bronchioles, alveolar ducts, and alveoli.", + "xrefs" : [ "MP:0010911", "PMID:2014492", "PMID:3382030", "Wikipedia:Acinus#The_Lungs" ] + }, + "xrefs" : [ { + "val" : "FMA:7313" + }, { + "val" : "NCIT:C33426" + }, { + "val" : "SCTID:361365004" + }, { + "val" : "Wikipedia:Acinus#The_Lungs" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008876", "lbl" : "hypodermis skeletal muscle layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any skeletal muscle organ in the hypodermis / superficial fascia.", + "xrefs" : [ "ISBN:0123813611", "MP:0011157" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18188" + }, { + "val" : "MA:0003140" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008886", "lbl" : "pulmonary vascular system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Pulmonary_circulation" ] + }, + "xrefs" : [ { + "val" : "FMA:45621" + }, { + "val" : "Wikipedia:Pulmonary_circulation" } ] } }, { @@ -21789,435 +77244,2026 @@ "lbl" : "splanchnocranium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Subdivision of endoskeleton derived from pharyngeal arches.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Facial_skeleton", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010157" + }, { + "val" : "TAO:0001216" + }, { + "val" : "VHOG:0000315" + }, { + "val" : "VSAO:0000149" + }, { + "val" : "Wikipedia:Facial_skeleton" + }, { + "val" : "XAO:0003176" + }, { + "val" : "ZFA:0001216" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008907", "lbl" : "dermal bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO].", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000130", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/267" ] + }, + "xrefs" : [ { + "val" : "AAO:0010769" + }, { + "val" : "TAO:0001590" + }, { + "val" : "VSAO:0000130" + }, { + "val" : "Wikipedia:Dermal_bone" + }, { + "val" : "XAO:0004015" + }, { + "val" : "ZFA:0001590" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008909", "lbl" : "perichordal bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bone element that is adjacent to the notochord.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000307", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AAO:0010777" + }, { + "val" : "TAO:0001639" + }, { + "val" : "VSAO:0000307" + }, { + "val" : "ZFA:0001629" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008946", "lbl" : "lung parenchyma", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A parenchyma that is part of a lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35522" + }, { + "val" : "FMA:27360" + }, { + "val" : "MA:0003168" + }, { + "val" : "SCTID:201712001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008947", "lbl" : "respiratory primordium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004069" + }, { + "val" : "NCIT:C34283" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008951", "lbl" : "left lung lobe", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lobe of lung that is part of a left lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:2981" + }, { + "val" : "NCIT:C48945" + }, { + "val" : "SCTID:272655003" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "lbl" : "submucosal esophageal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed.", + "xrefs" : [ "BTO:0003634", "Wikipedia:Esophageal_glands" ] + }, + "xrefs" : [ { + "val" : "BTO:0003634" + }, { + "val" : "FMA:9404" + }, { + "val" : "NCIT:C32536" + }, { + "val" : "SCTID:322749003" + }, { + "val" : "Wikipedia:Esophageal_glands" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008998", "lbl" : "vasculature of brain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "System pertaining to blood vessels in the brain.", + "xrefs" : [ "BTO:0003840" ] + }, + "xrefs" : [ { + "val" : "BTO:0003840" + }, { + "val" : "EFO:0003491" + }, { + "val" : "EMAPA:35186" + }, { + "val" : "FMA:242007" + }, { + "val" : "FMA:61935" + }, { + "val" : "SCTID:362029003" + }, { + "val" : "TAO:0000099" + }, { + "val" : "ZFA:0000099" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009015", "lbl" : "upper back skin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a dorsal thoracic segment of trunk.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000510" + }, { + "val" : "SCTID:304890003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009030", "lbl" : "left pulmonary vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vein that drains left lung and returns blood to the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0002207" + }, { + "val" : "NCIT:C48946" + }, { + "val" : "SCTID:304057004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009032", "lbl" : "right pulmonary vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vein that drains right lung and returns blood to the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0002208" + }, { + "val" : "NCIT:C48947" + }, { + "val" : "SCTID:304056008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009117", "lbl" : "indifferent gonad", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gonad prior to differentiating into a definitive testis or ovary.", + "xrefs" : [ "http://www.medterms.com/script/main/art.asp?articlekey=8981" ] + }, + "comments" : [ "typically part of the embryo - however, in male tammar wallabies the gonads are indifferent at the neonatal stage[8827321]" ], + "xrefs" : [ { + "val" : "EHDAA2:0000716" + }, { + "val" : "NCIT:C34192" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009127", "lbl" : "epibranchial ganglion", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Cranial ganglion which develops from an epibranchial placode.", + "xrefs" : [ "PMID:20133851", "ZFIN:curator" ] + }, + "comments" : [ "Epibranchial ganglia orchestrate the development of the cranial neurogenic crest" ], + "xrefs" : [ { + "val" : "TAO:0001555" + }, { + "val" : "ZFA:0001555" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009129", "lbl" : "right atrium endocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endocardium that is part of the right atrium.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000274" + }, { + "val" : "FMA:7281" + }, { + "val" : "NCIT:C102339" + }, { + "val" : "SCTID:3194006" + }, { + "val" : "VHOG:0001228" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009133", "lbl" : "pleuroperitoneal membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities.", + "xrefs" : [ "Wikipedia:Pleuroperitoneal", "http://medical-dictionary.thefreedictionary.com/pleuroperitoneal+membrane" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001483" + }, { + "val" : "EMAPA:17709" + }, { + "val" : "NCIT:C34256" + }, { + "val" : "SCTID:361429005" + }, { + "val" : "VHOG:0000757" + }, { + "val" : "Wikipedia:Pleuroperitoneal" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009141", "lbl" : "craniocervical region vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a craniocervical region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004542" + }, { + "val" : "SCTID:32945007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009142", "lbl" : "entire embryonic mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Sum total of mesenchyme in the embryo.", + "xrefs" : [ "https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/7" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001113" + }, { + "val" : "EHDAA:177" + }, { + "val" : "EMAPA:16097" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009145", "lbl" : "pharyngeal region of foregut", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:16549" + }, { + "val" : "RETIRED_EHDAA2:0001454" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "lbl" : "sphenoid bone pre-cartilage condensation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0003446" + }, { + "val" : "EMAPA:18015" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "lbl" : "sphenoid cartilage element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphenoid endochondral element that is composed primarily of cartilage tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001888" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009196", "lbl" : "indifferent external genitalia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004021" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009204", + "lbl" : "medial nasal process mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a medial nasal prominence.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001077" + }, { + "val" : "EMAPA:16810" + }, { + "val" : "FMA:312659" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009292", + "lbl" : "embryonic nasal process", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000581" + }, { + "val" : "EHDAA:4776" + }, { + "val" : "EMAPA:16680" + }, { + "val" : "SCTID:308881001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009479", "lbl" : "ectoderm of buccopharyngeal membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ectoderm that is part of a buccopharyngeal membrane.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000190" + }, { + "val" : "EMAPA:16260" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009480", "lbl" : "endoderm of buccopharyngeal membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endoderm that is part of a buccopharyngeal membrane.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000191" + }, { + "val" : "EMAPA:16261" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009482", + "lbl" : "associated mesenchyme of foregut-midgut junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a foregut-midgut junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000570" + }, { + "val" : "EMAPA:16364" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009483", + "lbl" : "mesentery of foregut-midgut junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a foregut-midgut junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000575" + }, { + "val" : "EMAPA:16365" + }, { + "val" : "VHOG:0000430" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009494", + "lbl" : "pharyngeal arch mesenchymal region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of mesenchymal tissue associated with an individual pharyngeal arch.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32755" + }, { + "val" : "FMA:295694" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "lbl" : "epithelium of foregut-midgut junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a foregut-midgut junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000573" + }, { + "val" : "EMAPA:16564" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009501", + "lbl" : "mesenchyme of fronto-nasal process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head.", + "xrefs" : [ "MP:0011266" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004109" + }, { + "val" : "EMAPA:16683" + }, { + "val" : "FMA:295821" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009503", + "lbl" : "mesenchyme of hindgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing hindgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000780" + }, { + "val" : "EMAPA:16716" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009505", + "lbl" : "mesenchyme of trachea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002067" + }, { + "val" : "EMAPA:16854" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009521", + "lbl" : "anal membrane endodermal component", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endoderm that is part of a anal region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004020" + }, { + "val" : "EMAPA:17177" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009526", + "lbl" : "maxillary process mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a maxillary prominence.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001071" + }, { + "val" : "EMAPA:17361" + }, { + "val" : "FMA:312691" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009548", + "lbl" : "hepatic sinusoid of left of lobe of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic sinusoid that is part of a left lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001001" + }, { + "val" : "EMAPA:18309" + }, { + "val" : "VHOG:0000709" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009549", + "lbl" : "hepatic sinusoid of right of lobe of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic sinusoid that is part of a right lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001009" + }, { + "val" : "EMAPA:18316" + }, { + "val" : "VHOG:0000710" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009550", + "lbl" : "endoderm of foregut-midgut junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endoderm that is part of a foregut-midgut junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000572" + }, { + "val" : "EMAPA:18403" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0009494", - "lbl" : "pharyngeal arch mesenchymal region", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0009566", + "lbl" : "intestinal submucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a intestine.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15696" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0009505", - "lbl" : "mesenchyme of trachea", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0009568", + "lbl" : "trunk region of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions.", + "xrefs" : [ "UBERONREF:0000006" ] + }, + "xrefs" : [ { + "val" : "FMA:72066" + }, { + "val" : "NCIT:C92597" + }, { + "val" : "SCTID:281699004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009569", "lbl" : "subdivision of trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:25054" + }, { + "val" : "SCTID:22943007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009570", "lbl" : "spinal cord sulcus limitans", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sulcus limitans of neural tube that is part of a future spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001265" + }, { + "val" : "EMAPA:17584" + }, { + "val" : "VHOG:0001548" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009576", "lbl" : "medulla oblongata sulcus limitans", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sulcus limitans of neural tube that is part of a future medulla oblongata.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001100" + }, { + "val" : "EMAPA:17561" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009577", "lbl" : "metencephalon sulcus limitans", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sulcus limitans of neural tube that is part of a future metencephalon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001161" + }, { + "val" : "EMAPA:17567" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009578", "lbl" : "myelencephalon sulcus limitans", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sulcus limitans of neural tube that is part of a future myelencephalon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001945" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009581", "lbl" : "midbrain mantle layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001172" + }, { + "val" : "EMAPA:16977" + }, { + "val" : "VHOG:0000910" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009583", "lbl" : "spinal cord mantle layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:17580" + }, { + "val" : "VHOG:0000911" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009584", "lbl" : "1st arch mandibular mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a 1st arch mandibular component.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000034" + }, { + "val" : "EMAPA:16385" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009602", "lbl" : "left lung associated mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing left lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000944" + }, { + "val" : "EMAPA:16730" + }, { + "val" : "EMAPA:17654" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009603", "lbl" : "right lung associated mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing right lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001739" + }, { + "val" : "EMAPA:17662" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009611", "lbl" : "midbrain neural plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural plate that develops_from a presumptive midbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0007019" + }, { + "val" : "ZFA:0007019" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009614", "lbl" : "hindbrain neural plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural plate that develops_from a presumptive hindbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0007022" + }, { + "val" : "ZFA:0007022" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009615", "lbl" : "midbrain hindbrain boundary neural plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "TAO:0007044" + }, { + "val" : "ZFA:0007044" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009616", "lbl" : "presumptive midbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A presumptive structure that has the potential to develop into a midbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BAMS:MES" + }, { + "val" : "EFO:0003432" + }, { + "val" : "EHDAA2:0000615" + }, { + "val" : "EMAPA:16140" + }, { + "val" : "TAO:0000148" + }, { + "val" : "Wikipedia:Mesencephalon" + }, { + "val" : "ZFA:0000148" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009617", "lbl" : "head paraxial mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles.", + "xrefs" : [ "PMID:21610022" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000736" + }, { + "val" : "EHDAA:364" + }, { + "val" : "EMAPA:16171" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009618", "lbl" : "trunk paraxial mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0002094" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009621", + "lbl" : "tail somite", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A somite that is part of a tail.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0010383" + }, { + "val" : "EMAPA:16860" + }, { + "val" : "XAO:0003143" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009644", "lbl" : "trachea non-cartilage connective tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "EMAPA:35878" + }, { + "val" : "MA:0001859" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009652", "lbl" : "bronchus basement membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A basement membrane that is part of a bronchus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001832" + }, { + "val" : "NCIT:C49208" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009653", "lbl" : "trachea basement membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A basement membrane that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001854" + }, { + "val" : "NCIT:C49302" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009657", "lbl" : "artery of lip", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "MA:0001987" + }, { + "val" : "NCIT:C52947" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009661", "lbl" : "midbrain nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Nucleus located in the midbrain.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "SCTID:279285003" + }, { + "val" : "TAO:0002209" + }, { + "val" : "ZFA:0001665" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009662", "lbl" : "hindbrain nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Nucleus located within the hindbrain.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "TAO:0002177" + }, { + "val" : "ZFA:0001658" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009664", + "lbl" : "gut mesentery", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004566" + }, { + "val" : "EMAPA:32911" + }, { + "val" : "MA:0003203" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "lbl" : "embryonic cloacal lumen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that surrounded_by a embryonic cloaca.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004586" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "lbl" : "rectal lumen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that surrounded_by a rectum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004587" + }, { + "val" : "EMAPA:18388" + }, { + "val" : "FMA:14598" + }, { + "val" : "SCTID:259740004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "lbl" : "dorsal pancreas", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001371" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "lbl" : "ventral pancreas", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001393" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009712", "lbl" : "endocardium of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any endocardium that is part of the right ventricle of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002188" + }, { + "val" : "EMAPA:17341" + }, { + "val" : "FMA:9536" + }, { + "val" : "NCIT:C102343" + }, { + "val" : "SCTID:8911002" + }, { + "val" : "VHOG:0001235" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009713", "lbl" : "endocardium of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any endocardium that is part of the left ventricle of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002182" + }, { + "val" : "EMAPA:17338" + }, { + "val" : "FMA:9559" + }, { + "val" : "SCTID:191004004" + }, { + "val" : "VHOG:0001233" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009715", "lbl" : "stomodeal lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a stomodeum.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009722", "lbl" : "entire pharyngeal arch endoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004621" + }, { + "val" : "EMAPA:32754" + }, { + "val" : "FMA:293087" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009751", "lbl" : "cardiac mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures.", + "xrefs" : [ "MP:0011264" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004162" + }, { + "val" : "EMAPA:36438" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009752", + "lbl" : "pancreas mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas.", + "xrefs" : [ "MP:0011265" ] + }, + "xrefs" : [ { + "val" : "EFO:0002557" + }, { + "val" : "EMAPA:26220" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009758", "lbl" : "abdominal ganglion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ganglion that is part of a abdominal segment of trunk.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:280508003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009778", "lbl" : "pleural sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous sac that has the pleura and the pleural cavity as parts.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004737" + }, { + "val" : "FMA:9690" + }, { + "val" : "SCTID:361996004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009842", "lbl" : "glandular acinus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form.", + "xrefs" : [ "Wikipedia:Acinus" ] + }, + "xrefs" : [ { + "val" : "FMA:55588" + }, { + "val" : "Wikipedia:Acinus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "lbl" : "embryonic cloacal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a embryonic cloaca.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004585" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009854", "lbl" : "digestive tract diverticulum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Branch or outpocketing of the digestive tract.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009856", "lbl" : "sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "galen:Diverticulum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009870", "lbl" : "zone of stomach", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Stomach#Sections" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35821" + }, { + "val" : "FMA:14558" + }, { + "val" : "MA:0002561" + }, { + "val" : "SCTID:245415005" + }, { + "val" : "Wikipedia:Stomach#Sections" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009881", "lbl" : "anterior lateral plate mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EFO:0003704" + }, { + "val" : "TAO:0005041" + }, { + "val" : "ZFA:0005041" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009889", "lbl" : "secondary heart field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).", + "xrefs" : [ "GO:0003139", "GOC:mtg_heart", "GOC:rl" ] + }, + "xrefs" : [ { + "val" : "XAO:0004186" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009891", "lbl" : "facial mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing face.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35337" + }, { + "val" : "FMA:302884" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009911", "lbl" : "lobule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:45737" + }, { + "val" : "NCIT:C12990" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009912", "lbl" : "anatomical lobe", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of an organ, such as the liver, lung, breast, or brain.", + "xrefs" : [ "ncithesaurus:Lobe" ] + }, + "xrefs" : [ { + "val" : "FMA:45728" + }, { + "val" : "NCIT:C13393" + }, { + "val" : "UMLS:C0796494" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009920", "lbl" : "optic neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001315" + }, { + "val" : "EHDAA:1122" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009953", "lbl" : "post-embryonic organism", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multicellular organism that existence_starts_with a post-embryonic stage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002405" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009955", "lbl" : "neurogenic placode", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia.", + "xrefs" : [ "PMID:11523831", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EFO:0003460" + }, { + "val" : "TAO:0001309" + }, { + "val" : "Wikipedia:Neurogenic_placodes" + }, { + "val" : "XAO:0004620" + }, { + "val" : "ZFA:0001309" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "lbl" : "epithelium of pancreatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a pancreatic duct.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0002556" + }, { + "val" : "FMA:67681" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010000", "lbl" : "multicellular anatomical structure", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "An anatomical structure that has more than one cell as a part.", + "xrefs" : [ "CARO:0010000" ] + }, + "xrefs" : [ { + "val" : "CARO:0010000" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010009", "lbl" : "aggregate regional part of brain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF].", + "xrefs" : [ "NLXANAT:20090509" ] + }, + "xrefs" : [ { + "val" : "NLXANAT:20090509" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010031", "lbl" : "6th arch mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a pharyngeal arch 6.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004076" + }, { + "val" : "EMAPA:32765" + }, { + "val" : "FMA:318209" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010039", "lbl" : "food storage organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ of the digestive tract that is capable of retaining and storing food.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BSA:0000123" + }, { + "val" : "TADS:0000172" + }, { + "val" : "TGMA:0001041" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010042", "lbl" : "1st arch mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a pharyngeal arch 1.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16128" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010045", + "lbl" : "1st arch maxillary mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a 1st arch maxillary component.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000041" + }, { + "val" : "EMAPA:16391" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010046", "lbl" : "entire pharyngeal arch associated mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells.", + "xrefs" : [ "XAO:0004524", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001459" + }, { + "val" : "EMAPA:16550" + }, { + "val" : "XAO:0004524" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010047", "lbl" : "oral gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Gland of the epithelium lining the oral cavity. The most common are the salivary glands.", + "xrefs" : [ "ISBN:0073040584" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001327" + }, { + "val" : "EHDAA:2181" + }, { + "val" : "EMAPA:16572" + }, { + "val" : "EMAPA:16723" + }, { + "val" : "VHOG:0000652" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010077", "lbl" : "cuboidal epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium consisting of cuboidal epithelial cells.", + "xrefs" : [ "Wikipedia:Cuboidal_epithelium" ] + }, + "xrefs" : [ { + "val" : "NCIT:C32415" + }, { + "val" : "Wikipedia:Cuboidal_epithelium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "lbl" : "future common hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An extrahepatic bile duct that has the potential to develop into a common hepatic duct.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000595" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010083", "lbl" : "future dermis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that has the potential to develop into a dermis.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000598" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010084", "lbl" : "future diaphragm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure that will develop into a diaphragm.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000599" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010092", "lbl" : "future metencephalon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developing anatomical structure that has the potential to develop into a metencephalon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000623" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010096", "lbl" : "future myelencephalon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developing anatomical structure that has the potential to develop into a myelencephalon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000640" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010125", "lbl" : "future superior salivatory nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gray matter that has the potential to develop into a superior salivatory nucleus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004644" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010131", "lbl" : "conducting tissue of heart", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004528" + }, { + "val" : "FMA:83378" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010136", "lbl" : "epithelial sheet", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial sheet is a flat surface consisting of closely packed epithelial cells.", + "xrefs" : [ "GO:0002011" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010152", + "lbl" : "skin mucus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucous secretion that is produced by glands in the epidermis.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010161", "lbl" : "lumen of blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a blood vessel.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:312610" + }, { + "val" : "SCTID:91747007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010162", + "lbl" : "post-anal tail tip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The distal end of the tail.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0002848" + }, { + "val" : "XAO:0004057" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010183", + "lbl" : "liver trabecula", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A trabecula that is part of a liver.", + "xrefs" : [ "GO:0060344", "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010188", "lbl" : "protuberance", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A roughly circular bulge in a surface.", + "xrefs" : [ "EHDAA2:0003250" ] + }, + "xrefs" : [ { + "val" : "AEO:0000205" + }, { + "val" : "EHDAA2:0003250" + }, { + "val" : "FMA:82506" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010191", "lbl" : "aortic system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004512" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010192", "lbl" : "genital artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the laterally paired arteries that supply the gonads.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Gonadal_artery" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Gonadal_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010194", + "lbl" : "hepatic portal system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver.", + "xrefs" : [ "ISBN:0073040584" ] + }, + "xrefs" : [ { + "val" : "AAO:0010225" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010199", "lbl" : "bona-fide anatomical boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical boundary that corresponds to some physical discontinuity.", + "xrefs" : [ "CARO:0001004" ] + }, + "comments" : [ "One might argue that all boundaries are actually fiat in the sense that there must be some fiat element at a fine enough scale of granularity. This ontology choses to ignore this issue as below the level of granularity relevant to anatomy. (DOS121102)" ], + "xrefs" : [ { + "val" : "CARO:0001004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010204", + "lbl" : "tail vasculature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a post-anal tail.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005037" + }, { + "val" : "XAO:0004151" + }, { + "val" : "ZFA:0005037" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010227", "lbl" : "future cardiac atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that is part of the heart tube and will become the cardiac atrium.", + "xrefs" : [ "ZFA:0001718" ] + }, + "xrefs" : [ { + "val" : "FMA:71005" + }, { + "val" : "TAO:0002228" + }, { + "val" : "ZFA:0001718" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010230", "lbl" : "eyeball of camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The core globe-shaped component of the camera-type eye.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:12513" + }, { + "val" : "MIAA:0000283" + }, { + "val" : "SCTID:244486005" + }, { + "val" : "VHOG:0001616" + }, { + "val" : "Wikipedia:Globe_(human_eye)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010243", "lbl" : "merocrine gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged.", + "xrefs" : [ "MGI:anna", "MP:0013544", "Wikipedia:Merocrine" ] + }, + "xrefs" : [ { + "val" : "BTO:0002324" + }, { + "val" : "MA:0003041" + }, { + "val" : "Wikipedia:Merocrine" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010252", "lbl" : "1st arch mandibular mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000037" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "lbl" : "1st arch maxillary mesenchyme from neural crest", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000044" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010256", "lbl" : "4th arch mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000098" + }, { + "val" : "EMAPA:16772" + }, { + "val" : "VHOG:0000580" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010257", "lbl" : "6th arch mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004077" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010258", "lbl" : "mesenchyme from rhombencephalic neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a rhombencephalon neural crest.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004423" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010259", "lbl" : "1st arch mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16129" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010276", + "lbl" : "space in vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any anatomical space that is part of a vertebral column.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000700" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010285", "lbl" : "midbrain basal plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that is dorsolateral to the floor plate and part of the midbrain.", + "xrefs" : [ "ZFA:0000761" ] + }, + "xrefs" : [ { + "val" : "DHBA:12322" + }, { + "val" : "EFO:0003567" + }, { + "val" : "EHDAA2:0004375" + }, { + "val" : "TAO:0000761" + }, { + "val" : "ZFA:0000761" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010286", "lbl" : "midbrain neural tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of neural tube that gives rise to the midbrain.", + "xrefs" : [ "ZFA:0007039" ] + }, + "xrefs" : [ { + "val" : "TAO:0007039" + }, { + "val" : "ZFA:0007039" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010291", "lbl" : "layer of sclera", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "Wikipedia:Sclera#Histology" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010294", "lbl" : "scleral endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a sclera.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010295", "lbl" : "substantia propria of sclera", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stroma that is part of a sclera.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:58365" + }, { + "val" : "NCIT:C33652" + }, { + "val" : "SCTID:368851004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010299", "lbl" : "scleral mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme surrounding the developing optic cup which develops into the sclera.", + "xrefs" : [ "PMID:16496288", "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010303", "lbl" : "extraembryonic epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a extraembryonic structure.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010312", "lbl" : "immature eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Developing anatomical structure that develops into the eyeball and associated structures.", + "xrefs" : [ "ZFA:0001678" ] + }, + "xrefs" : [ { + "val" : "TAO:0002201" + }, { + "val" : "ZFA:0001678" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010313", "lbl" : "neural crest-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops from the neural crest.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010314", "lbl" : "structure with developmental contribution from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that has some part that develops from the neural crest.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010316", "lbl" : "germ layer / neural crest", @@ -22225,177 +79271,826 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010321", "lbl" : "skeletal element of eye region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal element that is part of a orbital region.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010323", "lbl" : "cranial skeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000049", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AAO:0000109" + }, { + "val" : "AAO:0000971" + }, { + "val" : "AAO:0010185" + }, { + "val" : "TAO:0000737" + }, { + "val" : "VSAO:0000049" + }, { + "val" : "XAO:0003075" + }, { + "val" : "ZFA:0000737" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010329", "lbl" : "paired limb/fin bud mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a limb/fin bud.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010333", "lbl" : "extraembryonic membrane mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a extraembryonic membrane.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "lbl" : "maxillary process mesenchyme from neural crest", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004601" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "lbl" : "maxillary process mesenchyme from head mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004602" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010336", "lbl" : "mandibular process mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004603" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010337", "lbl" : "mandibular process mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004604" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010338", + "lbl" : "1st arch maxillary mesenchyme from head mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000043" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010339", "lbl" : "1st arch mandibular mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000036" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010341", "lbl" : "1st arch mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16130" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010345", "lbl" : "4th arch mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000097" + }, { + "val" : "EMAPA:16771" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010347", "lbl" : "6th arch mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004078" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010359", "lbl" : "pharyngeal arch mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme" ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010360", "lbl" : "pharyngeal arch mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme" ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010362", "lbl" : "endoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000037", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000037" + }, { + "val" : "Wikipedia:Endoskeleton" + }, { + "val" : "XAO:0004026" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010363", "lbl" : "endochondral element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000139", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000139" + }, { + "val" : "XAO:0004017" + }, { + "val" : "ZFA:0005620" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010364", "lbl" : "dermal skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000035", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "comments" : [ "This ontology covers metazoa, so we do not use exoskeleton as primary label, as in VSAO" ], + "xrefs" : [ { + "val" : "VSAO:0000035" + }, { + "val" : "XAO:0004025" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010368", "lbl" : "pulmonary lobule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa.", + "xrefs" : [ "ncithesaurus:Pulmonary_Lobule" ] + }, + "xrefs" : [ { + "val" : "FMA:75739" + }, { + "val" : "NCIT:C33428" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010369", "lbl" : "secondary pulmonary lobule", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa.", + "xrefs" : [ "PMID:3259815" ] + }, + "xrefs" : [ { + "val" : "FMA:7414" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010371", "lbl" : "ecto-epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium composed of cells that develops from the ectoderm[FMA,modified].", + "xrefs" : [ "FMA:69064" ] + }, + "xrefs" : [ { + "val" : "FMA:69064" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "lbl" : "pancreas dorsal primordium", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001384" + }, { + "val" : "FMA:79793" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "lbl" : "pancreas ventral primordium", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001387" + }, { + "val" : "FMA:79794" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010377", "lbl" : "mesenchyme from somatopleure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a somatopleure.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001120" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010378", "lbl" : "mesenchyme from splanchnopleure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a splanchnopleure.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001122" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "lbl" : "spleen trabecular artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the branches of the splenic artery[MP].", + "xrefs" : [ "MP:0002354", "Wikipedia:Trabecular_arteries" ] + }, + "xrefs" : [ { + "val" : "MA:0000759" + }, { + "val" : "NCIT:C49775" + }, { + "val" : "Wikipedia:Trabecular_arteries" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "lbl" : "spleen trabecular vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the veins that feed the splenic vein.", + "xrefs" : [ "MP:0002228", "Wikipedia:Trabecular_veins" ] + }, + "xrefs" : [ { + "val" : "MA:0000760" + }, { + "val" : "NCIT:C49779" + }, { + "val" : "Wikipedia:Trabecular_veins" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010409", "lbl" : "ocular surface region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms.", + "xrefs" : [ "MP:0013754" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35336" + }, { + "val" : "MA:0002486" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010427", "lbl" : "ciliary processes", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens.", + "xrefs" : [ "Wikipedia:Ciliary_processes" ] + }, + "xrefs" : [ { + "val" : "FMA:76551" + }, { + "val" : "SCTID:280860001" + }, { + "val" : "Wikipedia:Ciliary_processes" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010428", "lbl" : "flat bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow.", + "xrefs" : [ "Wikipedia:Flat_bone" ] + }, + "comments" : [ "Examples: cranium, the ilium, sternum, rib cage, the sacrum and the scapula; the occipital, parietal, frontal, nasal, lacrimal, vomer, scapula, os coxC&, sternum, and ribs" ], + "xrefs" : [ { + "val" : "FMA:7476" + }, { + "val" : "NCIT:C32616" + }, { + "val" : "SCTID:332907008" + }, { + "val" : "Wikipedia:Flat_bone" + }, { + "val" : "galen:FlatBone" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010498", "lbl" : "pseudostratified columnar epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels.", + "xrefs" : [ "Wikipedia:Pseudostratified_columnar_epithelium", "http://medical-dictionary.thefreedictionary.com/pseudostratified+epithelium" ] + }, + "xrefs" : [ { + "val" : "FMA:45572" + }, { + "val" : "NCIT:C33419" + }, { + "val" : "NCIT:C49316" + }, { + "val" : "Wikipedia:Pseudostratified_columnar_epithelium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010499", "lbl" : "pseudostratified ciliated columnar epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile.", + "xrefs" : [ "NCIT:NCIT" ] + }, + "xrefs" : [ { + "val" : "FMA:13146" + }, { + "val" : "NCIT:C13181" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010522", "lbl" : "replacement element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal element that forms as a replacement or substitution of another element or tissue.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000135", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000135" + }, { + "val" : "XAO:0004016" + }, { + "val" : "ZFA:0005624" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010523", + "lbl" : "microcirculatory vessel", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses.", + "xrefs" : [ "MESH:A07.231.432", "ZFA:0005251", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MESH:D055806" + }, { + "val" : "TAO:0005251" + }, { + "val" : "ZFA:0005251" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010527", + "lbl" : "cavity of bone organ", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ cavity that surrounded_by a bone.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:24021" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0010523", - "lbl" : "microcirculatory vessel", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0010528", + "lbl" : "pneumatic cavity of bone", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:24028" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010707", "lbl" : "appendage girdle complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).", + "xrefs" : [ "https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7182" + }, { + "val" : "VSAO:0000214" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010708", "lbl" : "pectoral complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle.", + "xrefs" : [ "VSAO:0000213" ] + }, + "xrefs" : [ { + "val" : "FMA:7183" + }, { + "val" : "SCTID:110716002" + }, { + "val" : "VSAO:0000213" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010719", "lbl" : "girdle skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The subdivision of the skeleton of either the pectoral or pelvic girdle.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010686" + }, { + "val" : "VSAO:0000302" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010740", "lbl" : "bone of appendage girdle complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle).", + "xrefs" : [ "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35494" + }, { + "val" : "MA:0000688" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010741", "lbl" : "bone of pectoral complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin.", + "xrefs" : [ "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35933" + }, { + "val" : "MA:0000612" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010891", "lbl" : "pectoral complex muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle of a pectoral girdle, pectoral fin or anterior limb.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010687" + }, { + "val" : "EMAPA:32624" + }, { + "val" : "FMA:9621" + }, { + "val" : "MA:0000615" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010912", "lbl" : "subdivision of skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.", + "xrefs" : [ "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:23879" + }, { + "val" : "SCTID:129140006" + }, { + "val" : "VSAO:0000042" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010913", + "lbl" : "vertebral element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal element that forms around the notochord and is part of the vertebral column.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/294" ] + }, + "xrefs" : [ { + "val" : "VHOG:0001143" + }, { + "val" : "VSAO:0000184" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010959", "lbl" : "craniocervical muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of either the head or the neck.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "NCIT:C32716" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011004", "lbl" : "pharyngeal arch cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage element that is part of a splanchnocranium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003689" + }, { + "val" : "TAO:0001460" + }, { + "val" : "ZFA:0001460" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "lbl" : "palatoquadrate arch", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG].", + "xrefs" : [ "VHOG:0000511", "https://github.com/obophenotype/uberon/issues/153" ] + }, + "xrefs" : [ { + "val" : "EFO:0003659" + }, { + "val" : "TAO:0001272" + }, { + "val" : "ZFA:0001272" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "lbl" : "vertebra cartilage element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32669" + }, { + "val" : "VHOG:0000584" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011095", + "lbl" : "vertebra pre-cartilage condensation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32671" + }, { + "val" : "VHOG:0000582" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011108", "lbl" : "synovial joint of pectoral girdle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A synovial joint that is part of a pectoral girdle region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:35243" + }, { + "val" : "SCTID:303080001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011134", "lbl" : "nonsynovial joint", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis.", + "xrefs" : [ "FMA:7491" ] + }, + "xrefs" : [ { + "val" : "FMA:7491" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011137", "lbl" : "axial skeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7483" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011138", "lbl" : "postcranial axial skeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/44", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:302077" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011148", + "lbl" : "submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue.", + "xrefs" : [ "BTO:0003751", "Wikipedia:Submucosal_glands" ] + }, + "xrefs" : [ { + "val" : "BTO:0003751" + }, { + "val" : "Wikipedia:Submucosal_glands" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011156", "lbl" : "facial skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skull that consists of the facial bones.", + "xrefs" : [ "MP:0005274", "Wikipedia:Facial_skeleton", "http://www.bartleby.com/107/37.html", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002206" + }, { + "val" : "EHDAA:8361" + }, { + "val" : "EMAPA:18022" + }, { + "val" : "FMA:53673" + }, { + "val" : "MA:0000318" + }, { + "val" : "Wikipedia:Facial_skeleton" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011158", "lbl" : "primary subdivision of skull", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The skull can be divided into two: the neurocranium and the facial skeleton.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:54964" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011159", "lbl" : "primary subdivision of cranial skeletal system", @@ -22403,346 +80098,1601 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011164", "lbl" : "neurocranium bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a neurocranium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35238" + }, { + "val" : "MA:0001478" + }, { + "val" : "SCTID:120229002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011171", + "lbl" : "joint connecting upper and lower jaws", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Synovial joint that articulates bones of upper and lower jaw.", + "xrefs" : [ "http://evolution.berkeley.edu/evolibrary/article/evograms_05", "https://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011185", + "lbl" : "gastrointestinal sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphincter muscle that is part of the gastrointestinal system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "NCIT:C32669" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011189", + "lbl" : "lamina propria of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a large intestine.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15654" + }, { + "val" : "NCIT:C49298" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011198", + "lbl" : "muscle layer of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of a large intestine.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14971" + }, { + "val" : "NCIT:C32927" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011201", + "lbl" : "muscle layer of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of a small intestine.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14932" + }, { + "val" : "NCIT:C33569" + }, { + "val" : "SCTID:362145004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011215", "lbl" : "central nervous system cell part cluster", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multi cell part structure that is part of a central nervous system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:83143" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011216", "lbl" : "organ system subdivision", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "A subdivision of an anatomical system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:67509" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "val" : "SCTID:91690000" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011222", "lbl" : "intra-ocular muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "AAO:0010038" + }, { + "val" : "EMAPA:18808" + }, { + "val" : "FMA:49150" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011233", "lbl" : "synovial membrane of synovial tendon sheath", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa.", + "xrefs" : [ "FMA:45087", "Wikipedia:Synovial_sheath" ] + }, + "comments" : [ "Alternate def: A synovial sheath is a layer of a tendon sheath containing tendons in the hand and foot. They lie internal to the fibrous tendon sheaths. An example is the common synovial sheath for the flexor tendons. [Wikipedia:Synovial_sheath]" ], + "xrefs" : [ { + "val" : "BTO:0001823" + }, { + "val" : "FMA:40878" + }, { + "val" : "Wikipedia:Synovial_sheath" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011234", "lbl" : "fibrous membrane of synovial tendon sheath", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:40877" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011241", + "lbl" : "ethmoid region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The most anterior region of the braincase. Provides structural support for peripheral olfactory organ.", + "xrefs" : [ "UBERONREF:0000007", "http://palaeos.com/vertebrates/bones/braincase/ethmoid.html" ] + }, + "xrefs" : [ { + "val" : "AAO:0000986" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011249", "lbl" : "appendicular skeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7484" + }, { + "val" : "VSAO:0000306" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011270", "lbl" : "dorsal trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the trunk that is in the dorsum[cjm].", + "xrefs" : [ "UBERONREF:0000006", "Wikipedia:Human_back" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35162" + }, { + "val" : "FMA:25056" + }, { + "val" : "MA:0000020" + }, { + "val" : "Wikipedia:Human_back" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011272", "lbl" : "embryonic skin basal layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001845" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011362", "lbl" : "cranial blood vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vasculature that is part of a head.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005297" + }, { + "val" : "ZFA:0005297" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011565", "lbl" : "lumen of gastrointestinal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:54364" + }, { + "val" : "SCTID:432899004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011566", "lbl" : "lumen of esophagus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that is part of a esophagus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18380" + }, { + "val" : "FMA:9398" + }, { + "val" : "SCTID:322648002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011582", "lbl" : "paired limb/fin skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The collection of all skeletal elements in an individual limb or fin.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000301" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011585", "lbl" : "cell condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995).", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000006", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000006" + }, { + "val" : "XAO:0004021" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011592", + "lbl" : "future upper lip", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0002120" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011595", "lbl" : "jaw region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32905" + }, { + "val" : "NCIT:C114916" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011596", "lbl" : "future lower lip", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001020" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011597", + "lbl" : "bone of upper jaw", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species).", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011642", "lbl" : "oral epithelium from ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that develops_from a ectoderm and is part of a oral epithelium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004137" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011648", "lbl" : "jaw muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "AAO:0000247" + }, { + "val" : "EFO:0003511" + }, { + "val" : "TAO:0000236" + }, { + "val" : "XAO:0003269" + }, { + "val" : "ZFA:0000236" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011676", "lbl" : "subdivision of organism along main body axis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "lbl" : "trunk vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly.", + "xrefs" : [ "UBERONREF:0000006" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011695", "lbl" : "embryonic cardiovascular system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiovascular system that is part of a conceptus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000216" + }, { + "val" : "FMA:305965" + }, { + "val" : "NCIT:C34148" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011772", "lbl" : "lower jaw opening", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is part of a bone of lower jaw.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000273" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011773", + "lbl" : "upper jaw opening", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is part of a bone of upper jaw.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000621" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011777", "lbl" : "nucleus of spinal cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural nucleus that is part of the spinal cord.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:77011" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011779", "lbl" : "nerve of head region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of a head.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011814", "lbl" : "non-neurogenic ectodermal placode", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ectodermal placode that does not develop into a component of the nervous system.", + "xrefs" : [ "PMID:11523831", "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011820", "lbl" : "atrioventricular region", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004149" + }, { + "val" : "FMA:85125" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011821", "lbl" : "irregular connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium.", + "xrefs" : [ "FMA:20107" ] + }, + "xrefs" : [ { + "val" : "FMA:20107" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011822", "lbl" : "dense irregular connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium.", + "xrefs" : [ "FMA:20109", "Wikipedia:Dense_irregular_connective_tissue" ] + }, + "xrefs" : [ { + "val" : "FMA:20109" + }, { + "val" : "NCIT:C32882" + }, { + "val" : "Wikipedia:Dense_irregular_connective_tissue" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011823", "lbl" : "dense connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets.", + "xrefs" : [ "Wikipedia:Dense_connective_tissue" ] + }, + "xrefs" : [ { + "val" : "AAO:0000121" + }, { + "val" : "NCIT:C32450" + }, { + "val" : "Wikipedia:Dense_connective_tissue" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011824", "lbl" : "fibrous connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:75634" + }, { + "val" : "SCTID:363130003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011825", "lbl" : "loose connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue.", + "xrefs" : [ "FMA:19783" ] + }, + "xrefs" : [ { + "val" : "FMA:19783" + }, { + "val" : "NCIT:C33007" + }, { + "val" : "Wikipedia:Loose_connective_tissue" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011858", "lbl" : "acinus of exocrine gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An acinus that is part of a exocrine gland.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011860", "lbl" : "collection of collagen fibrils", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:63212" + }, { + "val" : "MESH:D024022" + }, { + "val" : "NCIT:C32339" + }, { + "val" : "NIF_Subcellular:sao7547390221" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011861", "lbl" : "aorta collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity.", + "xrefs" : [ "MP:0011640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011862", "lbl" : "pulmonary collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity.", + "xrefs" : [ "MP:0011641" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011863", "lbl" : "bone collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity.", + "xrefs" : [ "MP:0011642" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011864", "lbl" : "tendon collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity.", + "xrefs" : [ "MP:0011643" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011865", "lbl" : "corneal stroma collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity.", + "xrefs" : [ "MP:0011650" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011878", + "lbl" : "muscle layer of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of a wall of esophagus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:62998" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011892", "lbl" : "anterior uvea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris.", + "xrefs" : [ "MP:0005194" ] + }, + "xrefs" : [ { + "val" : "SCTID:280656002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011899", "lbl" : "epimysium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous.", + "xrefs" : [ "Wikipedia:Epimysium" ] + }, + "xrefs" : [ { + "val" : "FMA:9726" + }, { + "val" : "NCIT:C32527" + }, { + "val" : "Wikipedia:Epimysium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011919", "lbl" : "yolk sac blood island", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Masses of developing blood cells attached to endothelium in the yolk sac.", + "xrefs" : [ "MP:0011204" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000177" + }, { + "val" : "EMAPA:16115" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011953", "lbl" : "stomach glandular region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of the stomach that is lined with glandular epithelium.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17623" + }, { + "val" : "MA:0001613" + }, { + "val" : "NCIT:C77661" + }, { + "val" : "SCTID:27633001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011955", + "lbl" : "left hepatic vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic vein that is part of a left lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14339" + }, { + "val" : "MA:0003032" + }, { + "val" : "SCTID:55188000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011956", + "lbl" : "right hepatic vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic vein that is part of a right lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14338" + }, { + "val" : "MA:0003034" + }, { + "val" : "SCTID:18135006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011997", "lbl" : "coelom", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregate of the coelemic cavity lumen plus the membranes that line the lumen.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Body_cavity", "Wikipedia:Coelom" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004731" + }, { + "val" : "Wikipedia:Coelom" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012054", "lbl" : "myocoele", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cavity within a myotome.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/myocoele" ] + }, + "xrefs" : [ { + "val" : "EMAPA:31134" + }, { + "val" : "VHOG:0001283" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012071", + "lbl" : "palate bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any bone that is part of a palate.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "NCIT:C33248" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012072", + "lbl" : "palatal part of dermatocranium", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012075", "lbl" : "replacement bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bone that forms as a replacement of another structural tissue.", + "xrefs" : [ "ZFA:0001628" ] + }, + "xrefs" : [ { + "val" : "AAO:0010768" + }, { + "val" : "TAO:0001637" + }, { + "val" : "ZFA:0001628" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012082", "lbl" : "bronchial lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that is part of a bronchus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:62646" + }, { + "val" : "SCTID:199401001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012172", "lbl" : "stomach primordium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A primordium that has the potential to develop into a stomach.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0002580" + }, { + "val" : "NCIT:C34305" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012180", "lbl" : "head or neck skin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a craniocervical region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000574" + }, { + "val" : "NCIT:C12294" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012193", "lbl" : "phrenic vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins.", + "xrefs" : [ "ncithesaurus:Phrenic_Vein" ] + }, + "xrefs" : [ { + "val" : "MA:0002194" + }, { + "val" : "NCIT:C53062" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012254", "lbl" : "abdominal aorta artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that originates from the abdominal aorta.", + "xrefs" : [ "Wikipedia:Abdominal_aorta#Branches", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "SCTID:281470000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012274", "lbl" : "columnar epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified].", + "xrefs" : [ "Wikipedia:Columnar_epithelium" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Columnar_epithelium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012275", "lbl" : "meso-epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium that derives from the mesoderm. [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:86452" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012314", "lbl" : "embryonic facial prominence", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of five swellings formed during the development of the face.", + "xrefs" : [ "http://www.indiana.edu/~anat550/hnanim/face/face.html" ] + }, + "xrefs" : [ { + "val" : "FMA:293103" + }, { + "val" : "SCTID:89066004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012320", "lbl" : "cervical artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery of the neck.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "NCIT:C52850" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012321", + "lbl" : "deep cervical artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The deep cervical artery (Profunda cervicalis) is an artery of the neck.", + "xrefs" : [ "Wikipedia:Deep_cervical_artery" ] + }, + "xrefs" : [ { + "val" : "FMA:10659" + }, { + "val" : "SCTID:244223002" + }, { + "val" : "Wikipedia:Deep_cervical_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012324", + "lbl" : "transverse cervical artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery.", + "xrefs" : [ "Wikipedia:Transverse_cervical_artery" ] + }, + "xrefs" : [ { + "val" : "FMA:10664" + }, { + "val" : "MA:0001936" + }, { + "val" : "SCTID:244224008" + }, { + "val" : "Wikipedia:Transverse_cervical_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012360", + "lbl" : "bone of jaw", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone element that is part of a jaw region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35453" + }, { + "val" : "MA:0003130" + }, { + "val" : "SCTID:369003004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012361", + "lbl" : "internal anal region", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004588" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012367", + "lbl" : "muscle layer of intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of an intestine.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15697" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012375", + "lbl" : "subserosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of tissue between the muscularis and serosa.", + "xrefs" : [ "Wikipedia:Subserosa" ] + }, + "comments" : [ "Contains nerves, blood vessels, lymphatics and lymph nodes" ], + "xrefs" : [ { + "val" : "FMA:45636" + }, { + "val" : "NCIT:C94494" + }, { + "val" : "SCTID:2255006" + }, { + "val" : "Wikipedia:Subserosa" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012416", + "lbl" : "respiratory system arterial smooth muscle", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "MA:0001802" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012418", + "lbl" : "respiratory system venous smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle tissue that is part of a respiratory system venous blood vessel.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001812" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012423", + "lbl" : "layer of microvilli", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified].", + "xrefs" : [ "GO:0005902", "Wikipedia:Microvillus" ] + }, + "xrefs" : [ { + "val" : "FMA:67296" + }, { + "val" : "MESH:D008871" + }, { + "val" : "NCIT:C33112" + }, { + "val" : "Wikipedia:Microvillus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012425", + "lbl" : "striated border microvillus layer", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A microvillus layer that is striated and found in the intestine.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/striated+border", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:70978" + }, { + "val" : "NCIT:C33634" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012429", + "lbl" : "hematopoietic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Blood-forming tissue, consisting of reticular fibers and cells.", + "xrefs" : [ "http://encyclopedia2.thefreedictionary.com/hematopoietic+tissue" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2142" + }, { + "val" : "FMA:14073" + }, { + "val" : "NCIT:C13051" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012430", + "lbl" : "tunica fibrosa of eyeball", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth.", + "xrefs" : [ "Wikipedia:Fibrous_tunic_of_eyeball" ] + }, + "xrefs" : [ { + "val" : "FMA:58102" + }, { + "val" : "SCTID:361318005" + }, { + "val" : "Wikipedia:Fibrous_tunic_of_eyeball" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "lbl" : "cloacal lumen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is enclosed by a cloaca.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0000330" + }, { + "val" : "ZFA:0000330" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012464", + "lbl" : "cloacal vent", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012465", + "lbl" : "lumen of terminal part of digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is enclosed by a terminal part of digestive tract.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012466", + "lbl" : "extraembryonic cavity", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000472" + }, { + "val" : "EMAPA:16054" + }, { + "val" : "VHOG:0000767" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012467", + "lbl" : "enclosed anatomical space", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space with no opening to another space or to the exterior.", + "xrefs" : [ "AEO:0000222" ] + }, + "xrefs" : [ { + "val" : "AEO:0000222" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012469", + "lbl" : "external anal region", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004589" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012475", + "lbl" : "skeleton of pectoral complex", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:24139" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012477", + "lbl" : "dorsal part of neck", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The posterior region of the neck, including the suboccipital region.", + "xrefs" : [ "MP:0012723" ] + }, + "xrefs" : [ { + "val" : "BTO:0000957" + }, { + "val" : "FMA:24189" + }, { + "val" : "SCTID:182326009" + }, { + "val" : "SCTID:304036007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012478", + "lbl" : "cloacal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a cloaca.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012480", + "lbl" : "cloacal mucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a cloaca [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012481", + "lbl" : "cloacal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a cloaca.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27577" + }, { + "val" : "EMAPA:36070" + }, { + "val" : "ZFA:0005783" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012482", + "lbl" : "submucosa of cloaca", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a cloaca [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012483", + "lbl" : "serosa of cloaca", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a cloaca [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012485", + "lbl" : "cloacal villus", "type" : "CLASS" }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012321", - "lbl" : "deep cervical artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0012486", + "lbl" : "muscle layer of cloaca", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscular coat that is part of a cloaca.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012488", + "lbl" : "muscle layer of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscular coat that is part of a duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14944" + }, { + "val" : "SCTID:362147007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012489", + "lbl" : "muscle layer of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscular coat that is part of a colon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27383" + }, { + "val" : "FMA:14986" + }, { + "val" : "MA:0003198" + }, { + "val" : "SCTID:362158003" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012490", + "lbl" : "muscle layer of anal canal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscular coat that is part of a anal canal.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15708" + }, { + "val" : "SCTID:362171000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012504", + "lbl" : "adventitia of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adventitia that is part of a esophagus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63006" + }, { + "val" : "SCTID:85950006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "lbl" : "gastroduodenal junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junction that connects a stomach and connects a duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:17046" + }, { + "val" : "SCTID:264014000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012651", + "lbl" : "mucosa of gastroduodenal junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a gastroduodenal junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0005415" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013126", + "lbl" : "vein of abdomen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a abdomen.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:281473003" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013127", + "lbl" : "pulmonary venous system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the venous system that drains the lungs[Kardong].", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Pulmonary_venous_system" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Pulmonary_venous_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013136", + "lbl" : "vein of lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that drains a lip.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:367664002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013140", + "lbl" : "systemic vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vein within the general circulation that transports blood back to the right atrium of the heart.", + "xrefs" : [ "ncithesaurus:Systemic_Vein" ] + }, + "xrefs" : [ { + "val" : "FMA:66644" + }, { + "val" : "NCIT:C33719" + }, { + "val" : "SCTID:244389004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013158", + "lbl" : "foregut-midgut junction gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a foregut-midgut junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000574" + }, { + "val" : "EMAPA:17065" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013212", + "lbl" : "anal sac gland secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bodily secretion that is produced by a gland of anal sac.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013232", + "lbl" : "serous acinus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ] + }, + "xrefs" : [ { + "val" : "FMA:86279" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013411", + "lbl" : "cranial cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cavity that is the lumen of the skull and contains the brain.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:9644" + }, { + "val" : "MA:0003061" + }, { + "val" : "NCIT:C77638" + }, { + "val" : "SCTID:264452006" + }, { + "val" : "Wikipedia:Cranial_cavity" + }, { + "val" : "neuronames:2806" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013479", + "lbl" : "lung endothelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel endothelium that is part of a lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004128" + }, { + "val" : "CALOHA:TS-0573" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013501", + "lbl" : "cloacal sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphincter muscle that is part of a cloaca.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "the muscles of the cloacal sphincter specialise into the perineal muscles in mammals (Gegenbaur, 1883; Popowsky, 1899; Nishi, 1938)." ], + "xrefs" : [ { + "val" : "NCIT:C34129" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "lbl" : "caudal vertebra cartilage element", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A caudal vertebra endochondral element that is composed primarily of cartilage tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000260" + }, { + "val" : "EMAPA:18044" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012324", - "lbl" : "transverse cervical artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0013504", + "lbl" : "caudal vertebra pre-cartilage condensation", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18045" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012360", - "lbl" : "bone of jaw", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012375", - "lbl" : "subserosa", + "id" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "lbl" : "cervical vertebra cartilage element", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cervical vertebra endochondral element that is composed primarily of cartilage tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000240" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012416", - "lbl" : "respiratory system arterial smooth muscle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0013506", + "lbl" : "cervical vertebra pre-cartilage condensation", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation.", + "xrefs" : [ "OBOL:automatic" ] + } } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012418", - "lbl" : "respiratory system venous smooth muscle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "lbl" : "thoracic vertebra cartilage element", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A thoracic vertebra endochondral element that is composed primarily of cartilage tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002014" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012429", - "lbl" : "hematopoietic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012430", - "lbl" : "tunica fibrosa of eyeball", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012466", - "lbl" : "extraembryonic cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012467", - "lbl" : "enclosed anatomical space", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012475", - "lbl" : "skeleton of pectoral complex", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012504", - "lbl" : "adventitia of esophagus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013126", - "lbl" : "vein of abdomen", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013127", - "lbl" : "pulmonary venous system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013136", - "lbl" : "vein of lip", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013140", - "lbl" : "systemic vein", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013232", - "lbl" : "serous acinus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013411", - "lbl" : "cranial cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013479", - "lbl" : "lung endothelium", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0013508", + "lbl" : "thoracic vertebra pre-cartilage condensation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013514", "lbl" : "space surrounding organism", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The space that surrounds an organism.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013522", "lbl" : "subdivision of tube", @@ -22750,111 +81700,379 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013525", "lbl" : "stomach lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The anatomical space that is enclosed by a stomach.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18395" + }, { + "val" : "FMA:14585" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013636", + "lbl" : "epithelium of intestinal villus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a intestinal villus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63587" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013685", "lbl" : "foramen of skull", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical space that is an opening in a bone of the skull.", + "xrefs" : [ "TAO:curator", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:53165" + }, { + "val" : "SCTID:276742007" + }, { + "val" : "Wikipedia:Foramina_of_the_skull" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013686", "lbl" : "anatomical conduit space", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified].", + "xrefs" : [ "FMA:9338", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:9338" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013694", "lbl" : "brain endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vascular endothelium found in blood vessels of the blood-brain-barrier.", + "xrefs" : [ "CALOHA:TS-0092" ] + }, + "xrefs" : [ { + "val" : "BTO:0001852" + }, { + "val" : "BTO:0003248" + }, { + "val" : "CALOHA:TS-0092" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013695", + "lbl" : "colon endothelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vascular endothelium found in colon blood vessels.", + "xrefs" : [ "CALOHA:TS-0162" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0162" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013697", + "lbl" : "exocrine pancreas epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium lining the exocrine pancreas.", + "xrefs" : [ "CALOHA:TS-2108" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2108" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013700", "lbl" : "axial musculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Musculature of the head and neck, spine, and ribs.", + "xrefs" : [ "HP:0003327" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000159" + }, { + "val" : "EMAPA:18166" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013701", "lbl" : "main body axis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013702", "lbl" : "body proper", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of the organism associated with the visceral organs.", + "xrefs" : [ "AEO:0000103" ] + }, + "xrefs" : [ { + "val" : "AEO:0000103" + }, { + "val" : "BTO:0001489" + }, { + "val" : "FMA:231424" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013704", "lbl" : "notochordal canal", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/notochordal+canal" ] + }, + "xrefs" : [ { + "val" : "FMA:293127" + }, { + "val" : "NCIT:C34230" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013727", "lbl" : "notochordal fluid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fluid contained within the notochordal canal.", + "xrefs" : [ "http://animaldiversity.org/accounts/Latimeria_chalumnae/", "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Distinct feature of coelocanths" ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013754", "lbl" : "integumentary system layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ component layer that is part of a integumental system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:314820002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013755", "lbl" : "arterial blood", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood that is part of a artery.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:83066" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013756", "lbl" : "venous blood", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood that is part of a vein.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:83067" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013757", "lbl" : "capillary blood", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood that is part of a capillary.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:263901" + }, { + "val" : "NCIT:C32212" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013765", "lbl" : "digestive system element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "SCTID:272627002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013768", "lbl" : "great vessel of heart", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart.", + "xrefs" : [ "Wikipedia:Great_vessels" ] + }, + "comments" : [ "Groupings may vary - typically pulmonary vessels and aorta and vena cavae" ], + "xrefs" : [ { + "val" : "EMAPA:36460" + }, { + "val" : "SCTID:304066000" + }, { + "val" : "Wikipedia:Great_vessels" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014387", "lbl" : "mesenchyme derived from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from the neural crest[Automatically generated definition].", + "xrefs" : [ "OBOL:automatic", "https://github.com/obophenotype/uberon/issues/248" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32735" + }, { + "val" : "FMA:293883" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014398", "lbl" : "respiratory muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle that is part of the respiratory system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014399", "lbl" : "sinusoidal space", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is enclosed by a sinusoid.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63133" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0014400", + "lbl" : "hepatic sinusoidal space", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sinusoidal space that is part of a hepatic sinusoid.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:262090" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014402", "lbl" : "sex-specific anatomical structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A part of the body present only in a specific gender.", + "xrefs" : [ "AEO:0000174", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000174" + }, { + "val" : "WBbt:0005752" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014404", "lbl" : "female anatomical structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A part of the body present only in females.", + "xrefs" : [ "AEO:0000176", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000176" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014454", "lbl" : "visceral abdominal adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subcutaneous adipose tissue that is located in the peritoneal cavity.", + "xrefs" : [ "CALOHA:paula", "MGI:csmith", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/259" ] + }, + "xrefs" : [ { + "val" : "BTO:0004041" + }, { + "val" : "CALOHA:TS-2405" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014455", "lbl" : "subcutaneous abdominal adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subcutaneous adipose tissue that is located in the abdominal region.", + "xrefs" : [ "CALOHA:paula", "MGI:csmith", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/259" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2406" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014477", "lbl" : "thoracic skeleton", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum.", + "xrefs" : [ "Wikipedia:Rib_cage", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002013" + }, { + "val" : "FMA:77169" + }, { + "val" : "Wikipedia:Thoracic_skeleton" } ] } }, { @@ -22862,9 +82080,14 @@ "lbl" : "thoracic spinal cord ventral horn", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A ventral horn of spinal cord that is part of a thoracic spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1410" + }, { + "val" : "SCTID:367876000" } ] } }, { @@ -22872,9 +82095,14 @@ "lbl" : "cervical spinal cord gray matter", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gray matter of spinal cord that is part of a cervical spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1521" + }, { + "val" : "SCTID:362438009" } ] } }, { @@ -22882,9 +82110,14 @@ "lbl" : "cervical spinal cord ventral horn", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A ventral horn of spinal cord that is part of a cervical spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1680" + }, { + "val" : "SCTID:174363005" } ] } }, { @@ -22892,23 +82125,89 @@ "lbl" : "thoracic spinal cord gray matter", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gray matter of spinal cord that is part of a thoracic spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:980" + }, { + "val" : "SCTID:362441000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "lbl" : "frontonasal process epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a frontonasal prominence.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004108" + }, { + "val" : "EMAPA:32918" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0014703", + "lbl" : "anal membrane ectodermal component", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A unilaminar epithelium that develops_from a ectoderm and is part of a anal region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004019" + }, { + "val" : "EMAPA:25040" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014704", "lbl" : "pleuroperitoneal canal lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is enclosed by a pleuroperitoneal canal.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004736" + }, { + "val" : "EMAPA:25034" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014716", "lbl" : "interlobular duct", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory.", + "xrefs" : [ "ncithesaurus:Interlobular_Duct" ] + }, + "xrefs" : [ { + "val" : "NCIT:C32828" + }, { + "val" : "UMLS:C1512857" + }, { + "val" : "Wikipedia:Interlobular_ducts" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0014717", + "lbl" : "mucous acinus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ] + }, + "xrefs" : [ { + "val" : "FMA:86278" } ] } }, { @@ -22916,263 +82215,1176 @@ "lbl" : "intralobular duct", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular.", + "xrefs" : [ "http://www.siumed.edu/~dking2/intro/glands.htm" ] + }, + "xrefs" : [ { + "val" : "SCTID:205214009" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014720", "lbl" : "interlobar duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory.", + "xrefs" : [ "http://www.siumed.edu/~dking2/intro/glands.htm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014776", "lbl" : "midbrain neuromere", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuromere that is part of the presumptive midbrain.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004352" + }, { + "val" : "FMA:61997" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014777", "lbl" : "spinal neuromere", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuromere that is part of the presumptive spinal cord.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001332" + }, { + "val" : "ZFA:0001332" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0014783", + "lbl" : "cloacal muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a cloaca.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014793", "lbl" : "musculature of pectoral complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:71296" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014794", "lbl" : "pectoral appendage muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin).", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014892", "lbl" : "skeletal muscle organ, vertebrate", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles).", + "xrefs" : [ "GOC:dos" ] + }, + "xrefs" : [ { + "val" : "AAO:0011099" + }, { + "val" : "BTO:0001103" + }, { + "val" : "CALOHA:TS-0933" + }, { + "val" : "EFO:0000888" + }, { + "val" : "EHDAA:5035" + }, { + "val" : "EHDAA:5043" + }, { + "val" : "EHDAA:5978" + }, { + "val" : "EHDAA:5984" + }, { + "val" : "EMAPA:35988" + }, { + "val" : "EV:0100377" + }, { + "val" : "GAID:141" + }, { + "val" : "MA:0003148" + }, { + "val" : "MAT:0000302" + }, { + "val" : "MESH:D018482" + }, { + "val" : "MIAA:0000302" + }, { + "val" : "TAO:0005277" + }, { + "val" : "VHOG:0000319" + }, { + "val" : "XAO:0000174" + }, { + "val" : "ZFA:0005277" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014903", "lbl" : "primordial vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of tissue that will develop into vasculature.", + "xrefs" : [ "ZFA:0005076", "ZFA:curator" ] + }, + "xrefs" : [ { + "val" : "EFO:0003708" + }, { + "val" : "TAO:0005076" + }, { + "val" : "ZFA:0005076" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014907", "lbl" : "intersomitic vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites.", + "xrefs" : [ "MGI:anna" ] + }, + "xrefs" : [ { + "val" : "EFO:0003664" + }, { + "val" : "TAO:0001285" + }, { + "val" : "XAO:0004075" + }, { + "val" : "ZFA:0001285" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015007", + "lbl" : "cervical vertebra endochondral element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vertebral endochondral element in the cervical region of the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "lbl" : "thoracic vertebra endochondral element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vertebral endochondral element in the thoracic region of the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015060", + "lbl" : "sphenoid endochondral element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphenoid bone or its cartilage or pre-cartilage precursor.", + "xrefs" : [ "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015128", "lbl" : "subepicardial layer of epicardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:83105" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015129", "lbl" : "epicardial fat", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Visceral intrapericardial fat contiguous with the myocardial surface.", + "xrefs" : [ "DOI:10.5935/abc.20130138" ] + }, + "xrefs" : [ { + "val" : "FMA:9871" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015152", "lbl" : "gland of ocular region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/614" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015165", "lbl" : "multi-unit eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An eye consisting of multiple light-sensing organs.", + "xrefs" : [ "PMID:21062451", "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015178", "lbl" : "somite border", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of somite adjacent to presomitic mesoderm.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001462" + }, { + "val" : "XAO:0004074" + }, { + "val" : "ZFA:0001462" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015179", "lbl" : "somite boundary epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium located in the intersomitic region.", + "xrefs" : [ "XAO:0004077", "XAO:EJS" ] + }, + "xrefs" : [ { + "val" : "XAO:0004077" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015203", "lbl" : "non-connected functional system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical group whose component structures share a common function.", + "xrefs" : [ "AEO:0000093", "AEO:JB", "FBC:DOS", "FBbt:00007278" ] + }, + "xrefs" : [ { + "val" : "AEO:0000093" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015204", "lbl" : "glandular system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A non-connected functional system that is composed primarily of a gland.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002223" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015212", "lbl" : "lateral structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any structure that is placed on one side of the left-right axis of a bilaterian.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015228", "lbl" : "circulatory organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015280", + "lbl" : "pancreas left lobe", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pancreatic lobule that is in_the_left_side_of a exocrine pancreas.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000722" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015281", + "lbl" : "pancreas right lobe", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pancreatic lobule that is in_the_right_side_of a exocrine pancreas.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000723" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015329", "lbl" : "respiratory system basement membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A basement membrane of epithelium that is part of a respiratory system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001815" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015410", "lbl" : "heart plus pericardium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "MA:0002449" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015480", + "lbl" : "proper hepatic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery.", + "xrefs" : [ "Wikipedia:Hepatic_artery_proper" ] + }, + "xrefs" : [ { + "val" : "FMA:14772" + }, { + "val" : "MA:0003095" + }, { + "val" : "SCTID:244262006" + }, { + "val" : "Wikipedia:Hepatic_artery_proper" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "lbl" : "left hepatic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic artery that is part of a left lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14779" + }, { + "val" : "MA:0003096" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "lbl" : "right hepatic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic artery that is part of a right lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14778" + }, { + "val" : "MA:0003097" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015485", + "lbl" : "choledocho-duodenal junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/choledochoduodenal+junction" ] + }, + "xrefs" : [ { + "val" : "MA:0003108" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015716", + "lbl" : "anal canal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a anal canal.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18835" + }, { + "val" : "FMA:17511" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015757", "lbl" : "heterogeneous tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:62798" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015783", "lbl" : "smooth muscle layer in fatty layer of subcutaneous tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle tissue that is part of a hypodermis.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:77862" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015796", + "lbl" : "liver blood vessel", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35498" + }, { + "val" : "MA:0003137" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015808", "lbl" : "eye epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a camera-type eye.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35957" + }, { + "val" : "MA:0003162" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015833", "lbl" : "foregut epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a foregut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32922" + }, { + "val" : "MA:0003204" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015834", + "lbl" : "duodenum lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27255" + }, { + "val" : "FMA:15972" + }, { + "val" : "MA:0003209" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016405", "lbl" : "pulmonary capillary", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A capillary that is part of a lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14121" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016458", "lbl" : "esophageal hiatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hole in the diaphragm through which the esophagus passes.", + "xrefs" : [ "HP:0002036" ] + }, + "xrefs" : [ { + "val" : "FMA:58289" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016478", + "lbl" : "liver stroma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stroma that is part of a liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:17553" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016490", "lbl" : "auditory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Is the sensory system for the sense of hearing.", + "xrefs" : [ "NLXANAT:090817" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36002" + }, { + "val" : "FMA:7192" + }, { + "val" : "MA:0002443" + }, { + "val" : "NCIT:C12889" + }, { + "val" : "NLXANAT:090817" + }, { + "val" : "Wikipedia:Auditory_system" + }, { + "val" : "neuronames:2888" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016509", "lbl" : "cavity of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Luminal space of the right ventricle of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26047" + }, { + "val" : "FMA:9291" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016512", + "lbl" : "lumen of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is part of a duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19080" + }, { + "val" : "FMA:14589" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016513", "lbl" : "cavity of left atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Luminal space of the left atrium of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26011" + }, { + "val" : "FMA:9465" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016514", "lbl" : "cavity of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Luminal space of the left ventricle of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26038" + }, { + "val" : "FMA:9466" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016522", "lbl" : "cavity of right atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Luminal space of the right atrium of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26020" + }, { + "val" : "FMA:11359" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016545", "lbl" : "pharyngeal ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches.", + "xrefs" : [ "PMID:23020903", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001379" + }, { + "val" : "ZFA:0001379" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016548", "lbl" : "central nervous system gray matter layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of of the central nervous system that is part of gray matter.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:83142" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016550", "lbl" : "spinal cord column", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016552", + "lbl" : "phlegm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mucus produced in the respiratory tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "NCIT:C93171" + }, { + "val" : "UMLS:C0225378" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016553", + "lbl" : "respiratory system mucus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm).", + "xrefs" : [ "Wikipedia:Nasal_mucus#Respiratory_system", "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016566", + "lbl" : "pit", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An roughly circular indentation in a surface.", + "xrefs" : [ "AEO:0000204", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000204" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016570", "lbl" : "lamina of gray matter of spinal cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:68861" + }, { + "val" : "Wikipedia:Rexed_laminae" + }, { + "val" : "http://neurolex.org/wiki/Category:Rexed_spinal_cord_parcellation_scheme_region" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "lbl" : "dorsal part of optic cup", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dorsal region of the optic cup that gives rise to the dorsal part of the retina.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016879", "lbl" : "future central nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primordium that develops into the central nervous system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016880", "lbl" : "future nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primordium that develops into the nervous system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000477" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016885", + "lbl" : "epithelium of terminal part of digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium lining the distalmost portion of the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0005445" + }, { + "val" : "WBbt:0005800" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016886", + "lbl" : "muscle tissue of terminal part of digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle tissue of the distalmost portion of the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016887", "lbl" : "entire extraembryonic component", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism.", + "xrefs" : [ "AEO:0000195", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000195" + }, { + "val" : "EHDAA2:0000003" + }, { + "val" : "EMAPA:16042" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016888", "lbl" : "transitional anatomical structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development.", + "xrefs" : [ "AEO:0000132", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000132" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0017650", "lbl" : "developing mesenchymal structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure.", + "xrefs" : [ "AEO:0001016", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0001016" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0017672", "lbl" : "abdominal viscera", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A viscus that is part of a abdomen.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:32413" + }, { + "val" : "FMA:67355" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018111", + "lbl" : "muscle layer of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of the rectum.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:15035" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "lbl" : "rectum smooth muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of smooth muscle tissue that is part of the rectum.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018135", "lbl" : "fibrocollagenous connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:83521" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018142", + "lbl" : "caudal vertebra endochondral element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018150", "lbl" : "skin of lower lip", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a lower lip.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:24767" + }, { + "val" : "SCTID:281630002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018151", + "lbl" : "skin of upper lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a upper lip.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:24765" + }, { + "val" : "SCTID:281629007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018234", + "lbl" : "stroma of pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stroma that is part of a pancreas.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63121" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018239", "lbl" : "rhombomere boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A boundary delimiting a rhombomere.", + "xrefs" : [ "GO:0021654" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018254", "lbl" : "skeletal musculature", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "EHDAA2:0001842" + }, { + "val" : "EMAPA:35578" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018257", "lbl" : "submucosa of digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of submucosa that lines the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018260", "lbl" : "layer of muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any organ component layer that consists of muscle tissue.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:45634" + }, { + "val" : "NCIT:C75444" + }, { + "val" : "UMLS:C0225358" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018261", + "lbl" : "muscular coat of digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscular coat that is part of a digestive tract.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018415", + "lbl" : "ethmoid foramen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An bone foramen in the ethmoid bone.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Taxon nodes: In humans, refers to anterior or posterior ethmoid foramina" ], + "xrefs" : [ { + "val" : "Wikipedia:Ethmoidal_foramina" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018543", + "lbl" : "lumen of intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The anatomical space within the intestine.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:14586" + }, { + "val" : "TADS:0000495" + }, { + "val" : "WBbt:0005791" + }, { + "val" : "ZFA:0005807" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018544", "lbl" : "trigeminal nerve muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle innervated by the trigeminal nerve (Cranial Nerve V).", + "xrefs" : [ "MFMO:0000072" ] + }, + "xrefs" : [ { + "val" : "MFMO:0000072" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018649", "lbl" : "cardiac muscle tissue of ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:83450" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018674", "lbl" : "heart vasculature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart.", + "xrefs" : [ "ZFA:0005811", "ZFA:CVS" ] + }, + "xrefs" : [ { + "val" : "FMA:73747" + }, { + "val" : "ZFA:0005811" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "lbl" : "dorsal side of post-anal tail", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018707", + "lbl" : "bladder organ", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membranous sac in animals that serves as the receptacle of a liquid or contains gas.", + "xrefs" : [ "BTO:0000123" ] + }, + "xrefs" : [ { + "val" : "BTO:0000123" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019042", "lbl" : "reproductive system mucosa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0002439" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019143", "lbl" : "intramuscular adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes.", + "xrefs" : [ "BTO:0004043" ] + }, + "xrefs" : [ { + "val" : "BTO:0004043" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019189", "lbl" : "carotid artery endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0004626" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "lbl" : "mucous gland of lung", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0004638" + }, { + "val" : "FMA:13119" + }, { + "val" : "SCTID:88410004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019204", "lbl" : "skin epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any region of epithelium that is part of a skin region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004382" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019207", "lbl" : "chorioretinal region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the eye that consists of both the retina and the optic choroid.", + "xrefs" : [ "UBERON:drseb", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "SCTID:110701000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019263", "lbl" : "gray matter of hindbrain", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "DHBA:10654" + }, { + "val" : "FMA:268630" } ] } }, { @@ -23180,81 +83392,211 @@ "lbl" : "gray matter of midbrain", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "DHBA:10649" + }, { + "val" : "FMA:83913" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019304", "lbl" : "sensory organ epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:35952" + }, { + "val" : "MA:0003174" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019319", "lbl" : "exocrine gland of integumental system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An exocrine gland that is part of a integumental system.", + "xrefs" : [ "GOC:dos", "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022288", "lbl" : "surface of eyeball", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:58315" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0022292", + "lbl" : "splenic arteriole", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "NCIT:C33596" + }, { + "val" : "SCTID:282511007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022293", "lbl" : "reproductive gland secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of organism substance that is secreted by a reproductive gland.", + "xrefs" : [ "UBERON:cjm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022303", "lbl" : "nervous system cell part layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO].", + "xrefs" : [ "NLX:149357" ] + }, + "xrefs" : [ { + "val" : "NLX:149357" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022350", "lbl" : "visceral serous membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Serous membrane layer that is adjacent to and lines an organ.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:15860" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022351", "lbl" : "parietal serous membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Serous membrane layer that lines to a body cavity.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:15859" + }, { + "val" : "MA:0002448" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022361", "lbl" : "lung field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specific region of the foregut into the area in which the lung will develop.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + }, + "xrefs" : [ { + "val" : "SCTID:34922002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034705", "lbl" : "developing neuroepithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryonic or larval epithelium that is committed to form part of the nervous system.", + "xrefs" : [ "AEO:0001008", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0001008" + }, { + "val" : "BTO:0000314" + }, { + "val" : "EHDAA2_RETIRED:0004654" + }, { + "val" : "FMA:64807" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034706", "lbl" : "proliferating neuroepithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells.", + "xrefs" : [ "AEO:0001009" ] + }, + "xrefs" : [ { + "val" : "AEO:0001009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034707", "lbl" : "differentiating neuroepithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells.", + "xrefs" : [ "AEO:0001010" ] + }, + "xrefs" : [ { + "val" : "AEO:0001010" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034709", "lbl" : "hindbrain marginal layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "DHBA:12694" + }, { + "val" : "EMAPA:32916" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034710", "lbl" : "spinal cord ventricular layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001267" + }, { + "val" : "EMAPA:17585" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034713", "lbl" : "cranial neuron projection bundle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain.", + "xrefs" : [ "ISBN:0471888893", "http://orcid.org/0000-0002-6601-2165" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034728", "lbl" : "autonomic nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa.", + "xrefs" : [ "Wikipedia:Autonomic_nerve" ] + }, + "xrefs" : [ { + "val" : "FMA:5866" + }, { + "val" : "MESH:D017776" + }, { + "val" : "SCTID:276145003" + }, { + "val" : "Wikipedia:Autonomic_nerve" } ] } }, { @@ -23262,31 +83604,74 @@ "lbl" : "sympathetic nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "SCTID:181098007" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034769", "lbl" : "lymphomyeloid tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:79770" + }, { + "val" : "NCIT:C41168" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034873", "lbl" : "bodily gas", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any substance in the body or expelled from the body that is in a gaseous state.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:84580" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034874", "lbl" : "air in respiratory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of gas located in a part of the respiratory system that is composed primarily of air.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:84581" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034878", "lbl" : "prechordal mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The area of axial mesoderm that develops into the prechordal plate.", + "xrefs" : [ "MGI:anna" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034903", "lbl" : "left atrium endocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endocardium that is part of the left atrium.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7286" + }, { + "val" : "SCTID:190064008" + }, { + "val" : "VHOG:0001226" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034905", "lbl" : "gland lumen", @@ -23296,15 +83681,12 @@ "lbl" : "multi organ part structure", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "An multicellular anatomical structure that has subparts of multiple organs as a part.", + "xrefs" : [ "CARO:0020001" ] + }, + "xrefs" : [ { + "val" : "CARO:0020001" } ] } }, { @@ -23312,15 +83694,14 @@ "lbl" : "cell cluster", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "definition" : { + "val" : "A cluster of cells, largely surrounded by a morphological boundary.", + "xrefs" : [ "CARO:0020002" ] + }, + "xrefs" : [ { + "val" : "CARO:0020002" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "FMA:62807" } ] } }, { @@ -23328,15 +83709,12 @@ "lbl" : "disconnected anatomical group", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other.", + "xrefs" : [ "CARO:0020000" ] + }, + "xrefs" : [ { + "val" : "CARO:0020000" } ] } }, { @@ -23344,45 +83722,133 @@ "lbl" : "anatomical collection", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" - } ] + "definition" : { + "val" : "A collection of anatomical structures that are alike in terms of their morphology or developmental origin.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034929", "lbl" : "external soft tissue zone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0034932", + "lbl" : "epithelium of biliary system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts.", + "xrefs" : [ "BTO:0001513", "MGI:cs", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001513" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034933", "lbl" : "layer of smooth muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any organ component layer that consists of smooth muscle tissue.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034944", "lbl" : "zone of organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:55268" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0034945", + "lbl" : "excreted gas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any gaseous product of an excretory process.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0034946", + "lbl" : "gas excreted from digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any excreted gas that is produced by the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "In mammals, mostly produced as a byproduct of bacterial fermentation in the gastrointestinal (GI) tract, especially the colon, and excreted through the rectum" ], + "xrefs" : [ { + "val" : "FMA:78440" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034947", "lbl" : "gas in respiratory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of gas located in a part of the respiratory system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034969", "lbl" : "epithelial layer of duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "NCIT:C25787" + }, { + "val" : "UMLS:C1512086" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034995", "lbl" : "jaw mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing jaw [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32907" + }, { + "val" : "EMAPA:35454" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035037", "lbl" : "jaw epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:32904" + }, { + "val" : "MA:0003220" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0035039", + "lbl" : "rectal artery", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "SCTID:277967008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035050", "lbl" : "excretory duct", @@ -23390,205 +83856,568 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035118", "lbl" : "material entity in digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included.", + "xrefs" : [ "https://github.com/EnvironmentOntology/envo/issues/110" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035159", "lbl" : "entire surface of organism", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface.", + "xrefs" : [ "FMA:61695" ] + }, + "xrefs" : [ { + "val" : "FMA:61695" + }, { + "val" : "NCIT:C29667" + }, { + "val" : "SCTID:261060002" + }, { + "val" : "UMLS:C0489451" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035398", "lbl" : "branch of external carotid artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:70505" + }, { + "val" : "NCIT:C32552" + }, { + "val" : "SCTID:244216003" + }, { + "val" : "UMLS:C0447038" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035539", "lbl" : "esophageal artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Any of several arteries that arise from the aorta and supply blood to the esophagus.", + "xrefs" : [ "ncithesaurus:Esophageal_Artery" ] + }, + "xrefs" : [ { + "val" : "FMA:4149" + }, { + "val" : "NCIT:C32535" + }, { + "val" : "SCTID:56548006" + }, { + "val" : "UMLS:C0226294" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035546", "lbl" : "uveal vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:51797" + }, { + "val" : "SCTID:149683007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0035548", + "lbl" : "colic artery", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "SCTID:77852007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035549", "lbl" : "vasculature of integument", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:225275" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035550", "lbl" : "superficial vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers.", + "xrefs" : [ "ncithesaurus:Superficial_Vein" ] + }, + "xrefs" : [ { + "val" : "FMA:76719" + }, { + "val" : "NCIT:C33666" + }, { + "val" : "SCTID:341382008" + }, { + "val" : "UMLS:C0226513" + }, { + "val" : "Wikipedia:Superficial_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035551", "lbl" : "deep vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035552", "lbl" : "deep vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery.", + "xrefs" : [ "ncithesaurus:Deep_Vein" ] + }, + "xrefs" : [ { + "val" : "FMA:76718" + }, { + "val" : "NCIT:C32444" + }, { + "val" : "SCTID:341484008" + }, { + "val" : "UMLS:C0226514" + }, { + "val" : "Wikipedia:Deep_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035553", "lbl" : "left cardiac chamber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any chamber of the left side of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7166" + }, { + "val" : "SCTID:362008007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035554", "lbl" : "right cardiac chamber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any chamber of the right side of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7165" + }, { + "val" : "SCTID:362007002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035639", "lbl" : "ocular adnexa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.", + "xrefs" : [ "HPO:pr", "UBERON:cjm", "http://medical-dictionary.thefreedictionary.com/ocular+adnexa", "https://github.com/obophenotype/uberon/issues/1132" ] + }, + "xrefs" : [ { + "val" : "FMA:76554" + }, { + "val" : "NCIT:C32574" + }, { + "val" : "SCTID:120612006" + }, { + "val" : "UMLS:C0229243" + }, { + "val" : "Wikipedia:Accessory_visual_structures" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035763", "lbl" : "cavity of cardiac chamber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004181" + }, { + "val" : "FMA:9464" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035767", "lbl" : "intrapulmonary bronchus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:223208" + }, { + "val" : "NCIT:C12930" + }, { + "val" : "UMLS:C1512970" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035804", "lbl" : "future mouth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The primordial mouth region of the developing head.", + "xrefs" : [ "MP:0003119" ] + }, + "xrefs" : [ { + "val" : "FMA:293105" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0035805", + "lbl" : "muscle layer of sigmoid colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of the sigmoid colon.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/1162" ] + }, + "xrefs" : [ { + "val" : "FMA:15028" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035809", "lbl" : "serous cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:12241" + }, { + "val" : "SCTID:304404008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035814", "lbl" : "pericardial fat", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sum of epicardial and paracardial fat deposits.", + "xrefs" : [ "DOI:10.5935/abc.20130138" ] + }, + "xrefs" : [ { + "val" : "SCTID:42267001" + }, { + "val" : "ZFA:0005765" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035815", "lbl" : "paracardial fat", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fat deposits in the mediastinum outside the parietal pericardium .", + "xrefs" : [ "DOI:10.5935/abc.20130138" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035818", "lbl" : "visceral fat", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fat deposit surrounding a visceral organ.", + "xrefs" : [ "UBERON:cjm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035819", "lbl" : "abdominopelvic cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:12267" + }, { + "val" : "Wikipedia:Abdominopelvic_cavity" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035820", "lbl" : "peritoneal sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16137" + }, { + "val" : "FMA:9908" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035965", "lbl" : "wall of blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0004378" + }, { + "val" : "FMA:67473" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036072", "lbl" : "respiratory primordium epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004070" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036073", "lbl" : "respiratory primordium mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004071" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036146", "lbl" : "cardiopharyngeal field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles.", + "xrefs" : [ "http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1", "https://orcid.org/0000-0003-3308-6245" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036186", "lbl" : "fibroelastic connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:83520" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0036214", + "lbl" : "rectosigmoid junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junction that is between the sigmoid colon and rectum.", + "xrefs" : [ "NCIT:C54188", "https://github.com/obophenotype/uberon/issues/1319", "https://www.cdc.gov/cancer/npcr/pdf/abstracting/colon.pdf" ] + }, + "xrefs" : [ { + "val" : "NCIT:C54188" + }, { + "val" : "SCTID:245429006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036215", "lbl" : "anatomical surface region", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "definition" : { + "val" : "Material anatomical entity that forms the outermost boundary of an anatomical structure.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/1324" ] + }, + "xrefs" : [ { + "val" : "AAO:0010270" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "ZFA:0005594" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036217", "lbl" : "coelomic fluid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bodily fluid that is located in the coelom.", + "xrefs" : [ "PMID:10874572", "https://github.com/obophenotype/uberon/issues/1326" ] + }, + "xrefs" : [ { + "val" : "BTO:0001708" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036225", "lbl" : "respiratory system gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any gland that is part os the respiratory system.", + "xrefs" : [ "UBERON:cjm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036242", "lbl" : "post-embryonic notochord", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_118072" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7737" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7746" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7878" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_8292" - } ] + "definition" : { + "val" : "A notochord that has persisted beyond the embryonic stage.", + "xrefs" : [ "UBERON:cjm" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036244", "lbl" : "secretion of serous membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transudate found in the serous sac.", + "xrefs" : [ "FMA:20932" ] + }, + "xrefs" : [ { + "val" : "FMA:20932" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036253", "lbl" : "orifice of skull", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:53133" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036264", "lbl" : "zygomaticotemporal nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit.", + "xrefs" : [ "Wikipedia:Zygomaticotemporal_nerve" ] + }, + "xrefs" : [ { + "val" : "FMA:52972" + }, { + "val" : "SCTID:280243001" + }, { + "val" : "Wikipedia:Zygomaticotemporal_nerve" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036285", "lbl" : "wall of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Wall of ventricle which is continuous with the wall of aorta.", + "xrefs" : [ "FMA:9556" ] + }, + "xrefs" : [ { + "val" : "FMA:9556" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036286", "lbl" : "wall of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Wall of ventricle which is continuous with the wall of pulmonary trunk.", + "xrefs" : [ "FMA:9533" ] + }, + "xrefs" : [ { + "val" : "FMA:9533" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036288", "lbl" : "anterior wall of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:9560" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036289", "lbl" : "anterior wall of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle.", + "xrefs" : [ "FMA:9553" ] + }, + "xrefs" : [ { + "val" : "FMA:9553" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036290", "lbl" : "myocardium of anterior wall of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:87177" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036291", "lbl" : "myocardium of anterior wall of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:260877" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036294", "lbl" : "mucosa of lip", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a lip region [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "NCIT:C12226" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0036301", + "lbl" : "vasculature of spleen", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:225251" + }, { + "val" : "SCTID:297287005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036302", "lbl" : "vasculature of central nervous system plus retina", @@ -23596,83 +84425,322 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036303", "lbl" : "vasculature of central nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:259905" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0036343", + "lbl" : "wall of gallbladder", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:14657" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036351", "lbl" : "wall of brachiocephalic artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:15089" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036352", "lbl" : "wall of subclavian artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:15090" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0036362", + "lbl" : "wall of anal canal", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:15704" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036422", "lbl" : "wall of pulmonary artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:18211" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036553", "lbl" : "wall of synovial tendon sheath", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:231590" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036925", "lbl" : "wall of eyeball", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:58098" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "lbl" : "wall of orbit", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:63144" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0037094", "lbl" : "wall of common carotid artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:66284" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0037144", "lbl" : "wall of heart", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees.", + "xrefs" : [ "FMA:7274" ] + }, + "xrefs" : [ { + "val" : "FMA:7274" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "lbl" : "cystic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that supplies oxygenated blood to the cystic duct.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "https://en.wikipedia.org/wiki/Cystic_artery" ] + }, + "xrefs" : [ { + "val" : "FMA:14835" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0039228", + "lbl" : "sigmoid vein", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:15395" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0039261", + "lbl" : "pancreatic artery", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:70471" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0039856", "lbl" : "right ovarian vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament.", + "xrefs" : [ "FMA:14342" ] + }, + "xrefs" : [ { + "val" : "FMA:14342" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0039857", "lbl" : "left ovarian vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament.", + "xrefs" : [ "FMA:14347" ] + }, + "xrefs" : [ { + "val" : "FMA:14347" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_1000021", "lbl" : "skin of face", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of the face.", + "xrefs" : [ "UBERON:EJS", "https://github.com/obophenotype/uberon/issues/34" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36657" + }, { + "val" : "FMA:24758" + }, { + "val" : "NCIT:C33561" + }, { + "val" : "SCTID:361703006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_1000024", + "lbl" : "parenchyma of spleen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A parenchyma that is part of a spleen.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:16029" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_1100000", "lbl" : "digestive tract junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junction between two parts of the digestive tract.", + "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_2001073", + "lbl" : "axial vasculature", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "ZFA:0001073" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_2001457", "lbl" : "postcranial axial cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cartilage which is part of the axial skeleton.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "ZFA:0001457" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_2005260", "lbl" : "fenestrated capillary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse.", + "xrefs" : [ "Wikipedia:Capillary#Types", "Wikipedia:Fenestra_(histology)" ] + }, + "xrefs" : [ { + "val" : "FMA:63196" + }, { + "val" : "NCIT:C32595" + }, { + "val" : "TAO:0005260" + }, { + "val" : "Wikipedia:Capillary#Types" + }, { + "val" : "ZFA:0005260" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_2007013", "lbl" : "preplacodal ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "ZFA:0007013" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_3000961", "lbl" : "external integument structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument.", + "xrefs" : [ "AAO:EJS" ] + }, + "comments" : [ "Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305" ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_3000972", "lbl" : "head external integument structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dermal, epidermal, glandular and pigment structures of the external head integument.", + "xrefs" : [ "AAO:EJS" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_3000977", "lbl" : "body external integument structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dermal, epidermal, glandular and pigment structures of the body integument.", + "xrefs" : [ "AAO:EJS" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_3000982", + "lbl" : "tail external integument structure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dermal, epidermal, glandular and pigment structures of the tail integument.", + "xrefs" : [ "AAO:EJS" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_3010200", "lbl" : "vasculature of respiratory integument", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Blood vessels in respiratory skin.", + "xrefs" : [ "AAO:EJS" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_4200230", "lbl" : "surface of bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical surface that is part of a bone.", + "xrefs" : [ "PHENOSCAPE" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_6000004", "lbl" : "panarthropod head", @@ -23680,100 +84748,368 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8000006", "lbl" : "left side of back", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.", + "xrefs" : [ "https://microbiomedb.org/" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8000007", "lbl" : "right side of back", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.", + "xrefs" : [ "https://microbiomedb.org/" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8000009", "lbl" : "Purkinje fiber network", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles.", + "xrefs" : [ "PMID:26786210" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8400021", + "lbl" : "liver serosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact.", + "xrefs" : [ "https://medical-dictionary.thefreedictionary.com/serosa+of+liver", "https://orcid.org/0000-0002-0449-2730" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8400023", + "lbl" : "liver subserosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson.", + "xrefs" : [ "FMA:15812", "https://medical-dictionary.thefreedictionary.com/subserosa+of+liver", "https://orcid.org/0000-0002-0449-2730" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410001", + "lbl" : "small intestine venule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Venule of villus of small intestine.", + "xrefs" : [ "https://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410004", + "lbl" : "small intestine arteriole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Arteriole of villus of small intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410008", + "lbl" : "venule of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A venule that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410009", + "lbl" : "arteriole of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arteriole that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410015", + "lbl" : "arteriole of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arteriole located in the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410024", + "lbl" : "intestinal junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junction between two parts of the intestine.", + "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410043", + "lbl" : "bronchus submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosal gland located in a bronchus.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410048", + "lbl" : "venule of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A venule located in the colon.", + "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "lbl" : "anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus.", + "xrefs" : [ "DOI:10.1007/978-3-319-26938-2_8", "DOI:10.1148/rg.2015150037", "PMID:29742860", "http://orcid.org/0000-0002-6826-8770", "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410056", + "lbl" : "capillary of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410057", + "lbl" : "capillary of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410068", + "lbl" : "capillary of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of a small intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "lbl" : "airway submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosal gland found in a respiratory tract.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ] + }, + "xrefs" : [ { + "val" : "EFO:0010666" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8410081", "lbl" : "blood microvessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins.", + "xrefs" : [ "Wikipedia:Microcirculation", "http://orcid.org/0000-0002-7073-9172" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8440015", "lbl" : "noradrenergic cell groups", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin).", + "xrefs" : [ "WikipediaVersioned:Noradrenergic_cell_groups&oldid=965992184" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8450002", "lbl" : "excretory system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An anatomical system that eliminates waste products that arise as a result of metabolic activity.", + "xrefs" : [ "GO:0007588" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8480001", "lbl" : "capillary of brain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of the brain.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8480002", "lbl" : "thoracic aorta smooth muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of the thoracic aorta.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8480025", "lbl" : "skin of clavicle region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is above the clavicle zone in the pectoral girdle region.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8480029", "lbl" : "skin of external genitalia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of the external genitalia.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8480074", "lbl" : "skin of gonad", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin part of some gonad.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8600004", "lbl" : "visceral muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle tissue that is associated with soft internal organs (viscera).", + "xrefs" : [ "BTO:0002780", "CLAO:0001295" ] + }, + "comments" : [ "It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated." ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8600006", "lbl" : "visceral striated muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A striated muscle tissue that is associated with soft internal organs (viscera).", + "xrefs" : [ "PMID:8720463", "https://pressbooks.pub/rbtallitsch/chapter/chapter-6-muscle-tissue/" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8600012", + "lbl" : "submucosal gland acinus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium.", + "xrefs" : [ "PMID:17394068", "PMID:17707699", "PMID:25648514", "PMID:30864819" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8600017", "lbl" : "bronchopulmonary segment", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface.", + "xrefs" : [ "FMA:7312", "PMID:18271171", "PMID:33620799", "doi:10.1016/j.mpaic.2008.09.022" ] + }, + "comments" : [ "A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung." ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8600024", "lbl" : "pulmonary venule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa.", + "xrefs" : [ "PMID:22283705", "PMID:30247823" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000050", "lbl" : "part of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "BFO:0000050" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000051", "lbl" : "has part", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "BFO:0000051" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000062", "lbl" : "preceded by", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "BFO:0000062" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000063", "lbl" : "precedes", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "BFO:0000063" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000066", "lbl" : "occurs in", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "BFO:0000066" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000067", "type" : "PROPERTY", @@ -23838,6 +85174,18 @@ "id" : "http://purl.obolibrary.org/obo/BSPO_0001107", "type" : "PROPERTY", "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "type" : "PROPERTY", + "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/BSPO_0005001", + "type" : "PROPERTY", + "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "type" : "PROPERTY", + "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/CL_4030045", "lbl" : "lacks_part", @@ -23852,27 +85200,52 @@ "id" : "http://purl.obolibrary.org/obo/GOREL_0002003", "lbl" : "results_in_distribution_of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "GOREL:0002003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GOREL_0002004", "lbl" : "results_in_fission_of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "GOREL:0002004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0000053", "lbl" : "bearer of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0000053" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0000056", "lbl" : "participates in", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0000056" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0000057", "lbl" : "has participant", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0000057" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0000086", "type" : "PROPERTY", @@ -23897,7 +85270,12 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002007", "lbl" : "bounding layer of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002082", "type" : "PROPERTY", @@ -23906,7 +85284,12 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002087", "lbl" : "immediately preceded by", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002087" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002100", "type" : "PROPERTY", @@ -23923,7 +85306,12 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002131", "lbl" : "overlaps", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002131" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002134", "type" : "PROPERTY", @@ -23960,7 +85348,12 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002180", "lbl" : "has component", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002180" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002202", "type" : "PROPERTY", @@ -23973,27 +85366,52 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002211", "lbl" : "regulates", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002211" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002212", "lbl" : "negatively regulates", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002212" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002213", "lbl" : "positively regulates", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002213" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002215", "lbl" : "capable of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002215" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002216", "lbl" : "capable of part of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002216" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002219", "type" : "PROPERTY", @@ -24002,7 +85420,12 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002220", "lbl" : "adjacent to", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002220" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002221", "type" : "PROPERTY", @@ -24015,6 +85438,15 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002224", "lbl" : "starts with", "type" : "PROPERTY", + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002224" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0002226", + "type" : "PROPERTY", "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/RO_0002229", @@ -24024,17 +85456,32 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002230", "lbl" : "ends with", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002230" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002231", "lbl" : "has start location", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002231" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002232", "lbl" : "has end location", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002232" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002252", "type" : "PROPERTY", @@ -24059,66 +85506,136 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002295", "lbl" : "results in developmental progression of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002295" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002296", "lbl" : "results in development of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002296" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002297", "lbl" : "results in formation of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002297" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002298", "lbl" : "results in morphogenesis of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002298" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002299", "lbl" : "results in maturation of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002299" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002315", "lbl" : "results in acquisition of features of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002315" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002328", "type" : "PROPERTY", "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0002332", + "lbl" : "regulates levels of", + "type" : "PROPERTY", + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002332" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002338", "lbl" : "has target start location", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002338" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002339", "lbl" : "has target end location", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002339" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002341", "lbl" : "results in transport along", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002341" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002342", "lbl" : "results in transport across", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002342" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002343", "lbl" : "results in growth of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002343" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002344", "lbl" : "results in transport to from or in", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002344" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002351", "type" : "PROPERTY", @@ -24127,11 +85644,20 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002353", "lbl" : "output of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002353" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002371", "type" : "PROPERTY", "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0002372", + "type" : "PROPERTY", + "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/RO_0002373", "type" : "PROPERTY", @@ -24204,6 +85730,15 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002565", "lbl" : "results in movement of", "type" : "PROPERTY", + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002565" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0002568", + "type" : "PROPERTY", "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/RO_0002570", @@ -24221,56 +85756,116 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002588", "lbl" : "results in assembly of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002588" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002590", "lbl" : "results in disassembly of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002590" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002592", "lbl" : "results in organization of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002592" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002608", "lbl" : "process has causal agent", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002608" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0003000", "lbl" : "produces", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0003000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0003001", "lbl" : "produced by", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0003001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0004007", "lbl" : "has primary input or output", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0004007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0004008", "lbl" : "has primary output", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0004008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0004009", "lbl" : "has primary input", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0004009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0012003", "lbl" : "acts on population of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0012003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0012008", "lbl" : "results in fusion of", "type" : "PROPERTY", + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0012008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0015004", + "lbl" : "has characterizing marker set", + "type" : "PROPERTY", "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/RO_0015015", @@ -24280,11 +85875,21 @@ "id" : "http://purl.obolibrary.org/obo/RO_0015016", "type" : "PROPERTY", "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/so#member_of", + "type" : "PROPERTY", + "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#anteriorly_connected_to", "lbl" : "anteriorly connected to", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y.", + "xrefs" : [ "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#channel_for", "lbl" : "channel for", @@ -24304,12 +85909,24 @@ "id" : "http://purl.obolibrary.org/obo/uberon/core#distally_connected_to", "lbl" : "distally connected to", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y.", + "xrefs" : [ "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into", "lbl" : "extends_fibers_into", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y", + "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#filtered_through", "lbl" : "filtered through", @@ -24318,13 +85935,35 @@ "meta" : { "definition" : { "val" : "Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity." + }, + "comments" : [ "Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed" ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies", + "lbl" : "indirectly_supplies", + "type" : "PROPERTY", + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s." } } + }, { + "id" : "http://purl.obolibrary.org/obo/uberon/core#layer_part_of", + "lbl" : "layer part of", + "type" : "PROPERTY", + "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#posteriorly_connected_to", "lbl" : "posteriorly connected to", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y.", + "xrefs" : [ "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#protects", "lbl" : "protects", @@ -24334,7 +85973,13 @@ "id" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to", "lbl" : "proximally connected to", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y.", + "xrefs" : [ "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#site_of", "lbl" : "site_of", @@ -24349,7 +85994,10 @@ "id" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", "lbl" : "subdivision of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "comments" : [ "placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B" ] + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#transitively_anteriorly_connected_to", "lbl" : "transitively anteriorly connected to", @@ -24373,10 +86021,6 @@ "id" : "http://purl.obolibrary.org/obo/IAO_0000700", "type" : "PROPERTY", "propertyType" : "ANNOTATION" - }, { - "id" : "http://purl.obolibrary.org/obo/RO_0002175", - "type" : "PROPERTY", - "propertyType" : "ANNOTATION" }, { "id" : "http://purl.obolibrary.org/obo/STATO_0000663", "type" : "PROPERTY", @@ -24412,8 +86056,73 @@ "lbl" : "title", "type" : "PROPERTY", "propertyType" : "ANNOTATION" + }, { + "id" : "http://www.geneontology.org/formats/oboInOwl#hasDbXref", + "lbl" : "database_cross_reference", + "type" : "PROPERTY", + "propertyType" : "ANNOTATION" + }, { + "id" : "http://www.w3.org/2000/01/rdf-schema#comment", + "type" : "PROPERTY", + "propertyType" : "ANNOTATION" } ], "edges" : [ { + "sub" : "http://identifiers.org/ensembl/ENSG00000038945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000050730", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000100292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000131471", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000137804", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000139329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000163735", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000164120", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000166803", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000168079", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000170323", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000171848", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000174807", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000175063", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { "sub" : "http://purl.obolibrary.org/obo/CHEBI_24431", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000040" @@ -24425,6 +86134,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000000", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_131567" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000000", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037006" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000005", "pred" : "is_a", @@ -24881,6 +86594,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000082", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000083", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002076" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000083", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000084", "pred" : "is_a", @@ -25233,6 +86954,34 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000167", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0030072" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000168", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000154" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000168", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000167" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000168", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000169", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000168" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000169", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0008024" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000169", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000169", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0002351" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000170", "pred" : "is_a", @@ -25241,6 +86990,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000170", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0070091" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002067" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0008024" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000171", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0002351" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000172", "pred" : "is_a", @@ -25249,6 +87014,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000172", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0070253" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000173", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000502" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000173", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0008024" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000173", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000173", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0002351" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000174", "pred" : "is_a", @@ -25257,6 +87038,34 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000174", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0035929" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000066" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000417" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0005026" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0098754" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000183", "pred" : "is_a", @@ -25521,6 +87330,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000313", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000319", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000319", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0070254" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000322", "pred" : "is_a", @@ -25633,6 +87450,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000355", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000188" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000358", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000192" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000358", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000359", "pred" : "is_a", @@ -25697,6 +87522,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000404", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000211" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000412", + "pred" : "http://purl.obolibrary.org/obo/RO_0000053", + "obj" : "http://purl.obolibrary.org/obo/PATO_0001377" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000413", "pred" : "is_a", @@ -25705,6 +87538,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000413", "pred" : "http://purl.obolibrary.org/obo/RO_0000053", "obj" : "http://purl.obolibrary.org/obo/PATO_0001375" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000417", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000412" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000447", "pred" : "is_a", @@ -25793,6 +87630,46 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000499", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_0000134" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000502", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000164" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000502", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000172" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000506", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000507" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000507", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000167" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000164" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000506" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000509" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002180" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000508", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004997" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000509", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000167" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000513", "pred" : "is_a", @@ -26369,6 +88246,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000583", "pred" : "http://purl.obolibrary.org/obo/RO_0002104", "obj" : "http://purl.obolibrary.org/obo/PR_000002972" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000583", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037003" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000583", "pred" : "http://purl.obolibrary.org/obo/RO_0015016", @@ -26397,10 +88278,30 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000604", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_0002672" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000622", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000150" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000622", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000154" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000622", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009842" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000630", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000666", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000666", + "pred" : "http://purl.obolibrary.org/obo/RO_0000053", + "obj" : "http://purl.obolibrary.org/obo/PATO_0002064" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000667", "pred" : "is_a", @@ -28105,6 +90006,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002063", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_4040003" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000622" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001599" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002064", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001263" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002064", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/GO_0042589" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002067", "pred" : "is_a", @@ -28169,6 +90086,34 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002078", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_0000222" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002079", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000069" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002079", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001433" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002079", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001064" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002079", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0015106" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002080", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001433" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002080", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001263" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002080", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0015106" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002086", "pred" : "is_a", @@ -28181,6 +90126,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002087", "pred" : "http://purl.obolibrary.org/obo/CL_4030045", "obj" : "http://purl.obolibrary.org/obo/GO_0030141" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002088", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000710" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002088", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0043134" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002092", "pred" : "is_a", @@ -28289,6 +90242,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002194", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0030224" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002195", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000048" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002195", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002202", "pred" : "is_a", @@ -28353,6 +90314,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002242", "pred" : "http://purl.obolibrary.org/obo/RO_0000053", "obj" : "http://purl.obolibrary.org/obo/PATO_0002505" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002243", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000358" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002243", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001607" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002243", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0000133" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002246", "pred" : "is_a", @@ -28381,6 +90354,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002252", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002253", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002254", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002254", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002262", "pred" : "is_a", @@ -28397,6 +90386,42 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002264", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0002659" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002265", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000502" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002265", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0009042" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002266", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000502" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002266", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0009006" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002267", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000502" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002267", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002659" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000696" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0008024" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002275", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000006" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002308", "pred" : "is_a", @@ -28461,6 +90486,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002350", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002165" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002351", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0011026" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002352", "pred" : "is_a", @@ -28597,6 +90626,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002503", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005742" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002504", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000192" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002504", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002521", "pred" : "is_a", @@ -28605,6 +90642,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002521", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002190" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002538", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002538", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004823" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002539", "pred" : "is_a", @@ -28677,6 +90722,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002557", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002012" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002563", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002251" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002563", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001277" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002570", "pred" : "is_a", @@ -28685,6 +90738,34 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002570", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001013" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002571", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000134" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002571", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002195" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002572", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000134" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002572", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0001035" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002572", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000499" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002574", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002575", "pred" : "is_a", @@ -28829,6 +90910,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002657", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0002252" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002658", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000150" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002658", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002253" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002659", "pred" : "is_a", @@ -28873,6 +90962,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002676", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_0000333" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002680", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000696" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002680", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001516" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0005000", "pred" : "is_a", @@ -28885,6 +90982,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0005012", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000067" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0005026", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000048" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0007001", "pred" : "is_a", @@ -28985,6 +91086,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0008022", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002062" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0008024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000083" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0008024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000164" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0008028", "pred" : "is_a", @@ -29029,6 +91138,130 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0009004", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005388" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009006", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001516" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009006", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001598" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009018", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000542" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009018", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011189" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000499" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009021", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011189" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009022", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000499" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009022", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001238" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002254" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009025", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009025", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0011108" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009038", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000235" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009038", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009040", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0009021" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009040", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007177" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009042", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001516" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009042", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001588" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009044", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000542" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009044", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001238" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009048", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000235" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009048", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009051", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000084" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009051", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009052", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000279" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009052", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009053", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0009021" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009053", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009063", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002658" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009063", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001516" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009063", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0009089", "pred" : "is_a", @@ -29037,6 +91270,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0009089", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002048" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009094", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002543" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009094", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001639" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0009097", "pred" : "is_a", @@ -29045,6 +91286,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0009097", "pred" : "http://purl.obolibrary.org/obo/RO_0002491", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000068" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009100", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000057" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009100", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001279" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0010001", "pred" : "is_a", @@ -29229,6 +91478,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0011030", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_2000010" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0011108", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002253" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0011108", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000397" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0011115", "pred" : "is_a", @@ -29301,6 +91558,30 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0019019", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007196" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019020", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019020", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004822" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000398" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019021", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001279" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019022", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000398" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019022", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006841" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000222", "pred" : "is_a", @@ -29365,6 +91646,54 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1000274", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000349" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002504" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000275", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000276", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000275" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000276", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000279", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002504" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000279", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000280", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000279" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000280", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000285", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000280" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000285", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000286", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000279" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000286", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000303", "pred" : "is_a", @@ -29489,6 +91818,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1000376", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002094" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000398", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000666" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000398", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002262" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000398", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001281" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000409", "pred" : "is_a", @@ -29541,6 +91882,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1000414", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001979" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000415", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000066" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000415", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000428", "pred" : "is_a", @@ -29609,6 +91958,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1000482", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002094" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000488", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000488", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000069" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000488", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000488", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0005026" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000490", "pred" : "is_a", @@ -29641,6 +92006,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1000493", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002401" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001433", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000083" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001433", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001516", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000164" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001516", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1001567", "pred" : "is_a", @@ -29657,6 +92038,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1001568", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005317" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001572", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001572", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013695" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1001576", "pred" : "is_a", @@ -29669,6 +92058,70 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1001576", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002424" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001588", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002658" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001588", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0011108" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001589", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001598" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001589", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008346" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001592", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000150" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001592", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000415" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001592", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002029" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001595", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002658" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001595", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003354" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001598", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000150" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001598", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002254" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001598", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001902" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001599", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000150" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001599", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000152" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001599", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001433" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001599", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013697" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1001603", "pred" : "is_a", @@ -29829,6 +92282,30 @@ "sub" : "http://purl.obolibrary.org/obo/CL_2000047", "pred" : "http://purl.obolibrary.org/obo/RO_0002100", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002298" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000051", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000057" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000051", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000053", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000053", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000055", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000451" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000055", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/CL_2000063", "pred" : "is_a", @@ -29869,6 +92346,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_2000068", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002407" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000069", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000057" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000069", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/CL_2000070", "pred" : "is_a", @@ -29897,6 +92382,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_2000073", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000095" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000074", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000738" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000074", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/CL_2000080", "pred" : "is_a", @@ -29985,6 +92478,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4028004", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002299" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4028004", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037002" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4028006", "pred" : "is_a", @@ -29997,6 +92494,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4028006", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002299" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4028006", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037001" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4030029", "pred" : "is_a", @@ -30021,6 +92522,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4030034", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004802" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033005", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000152" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033005", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0019001" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033005", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410043" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4033008", "pred" : "is_a", @@ -30049,6 +92562,46 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4033018", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000114" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033020", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000307" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033020", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_4033037" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033020", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005203" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033022", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002328" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033022", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_4033037" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033022", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410043" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033037", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000152" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033037", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000319" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033037", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002202" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033037", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410077" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4033041", "pred" : "is_a", @@ -30057,10 +92610,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4033041", "pred" : "http://purl.obolibrary.org/obo/RO_0002292", "obj" : "http://purl.obolibrary.org/obo/PR_000002123" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033041", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037004" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4033042", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000583" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033042", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037005" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4033054", "pred" : "is_a", @@ -30069,6 +92630,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4033054", "pred" : "http://purl.obolibrary.org/obo/RO_0002220", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033061", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002543" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033061", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006841" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4037001", "pred" : "is_a", @@ -30165,6 +92734,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0000271", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18154" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0000272", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0000272", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18154" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0000278", "pred" : "is_a", @@ -30417,6 +92994,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0001654", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000970" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001655", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048731" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001655", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/GO_0072001" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001655", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004122" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0001659", "pred" : "is_a", @@ -30453,6 +93042,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0001677", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0044207" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001678", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019725" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001678", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0001696", "pred" : "is_a", @@ -30969,6 +93566,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0001886", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/CL_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001889", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048732" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001889", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001889", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0001894", "pred" : "is_a", @@ -31329,6 +93938,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0002250", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0002251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006955" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0002252", "pred" : "is_a", @@ -31545,6 +94158,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0002376", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0002384", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0002384", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0002384", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0002396", "pred" : "is_a", @@ -32833,6 +95458,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0003013", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0003008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003014", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003008" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0003015", "pred" : "is_a", @@ -33365,6 +95994,42 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0003221", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003381" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055010" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061384" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003222", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004126" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003225", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003220" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003225", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003222" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003225", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005064" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003221" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003222" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003227", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005066" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0003228", "pred" : "is_a", @@ -33601,6 +96266,54 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0003301", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0055017" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003309", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0035883" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003309", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031018" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003309", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0000169" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003310", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0035883" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003310", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031018" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003310", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0000171" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003311", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0035883" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003311", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031018" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003311", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0000173" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003312", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0035883" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003312", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031018" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003312", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0002275" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0003313", "pred" : "is_a", @@ -33641,6 +96354,54 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0003315", "pred" : "http://purl.obolibrary.org/obo/RO_0002297", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004291" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003322", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002068" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003322", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003310" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003322", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/CL_0000171" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003323", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002068" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003323", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003309" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003323", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/CL_0000169" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003324", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002068" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003324", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003311" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003324", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/CL_0000173" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003325", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002068" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003325", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003312" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003325", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/CL_0002275" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0003341", "pred" : "is_a", @@ -33877,6 +96638,82 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0003433", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0003413" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003674", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/BFO_0000015" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003824", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0004518", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0016788" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0004536", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0004518" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0004536", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140097" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0004536", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0006259" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005215", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005275", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0015837" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005275", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_32952" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005319", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005319", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0006869" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005319", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005342", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_1903825" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005342", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005355", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005355", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_1904659" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005355", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0005575", "pred" : "is_a", @@ -34205,6 +97042,82 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0005976", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18154" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005977", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005975" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005977", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006112" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005977", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005977", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_28087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005978", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005977" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005978", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009250" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005978", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_28087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005979", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010962" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005979", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070873" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005979", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0005978" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005980", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005980", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_28087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005981", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043470" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005981", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070873" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005981", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0005980" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006006", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019318" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006006", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006007", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006007", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006024", "pred" : "is_a", @@ -34213,6 +97126,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006024", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006027", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006027", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006082", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044237" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006082", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006082", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006091", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044237" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006094", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006094", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006109", "pred" : "is_a", @@ -34221,6 +97166,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006109", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0005975" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006111", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006111", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006094" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0015980" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006139", "pred" : "is_a", @@ -34237,6 +97194,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006259", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006308", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006308", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/GO_0004536" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006308", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006309", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006308" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006309", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0030262" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006325", "pred" : "is_a", @@ -34245,6 +97222,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006325", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", "obj" : "http://purl.obolibrary.org/obo/GO_0000785" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006401", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006401", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33697" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006403", "pred" : "is_a", @@ -34345,6 +97330,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006449", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0006415" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006516", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006516", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17089" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006518", "pred" : "is_a", @@ -34377,6 +97370,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006629", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006694", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006694", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008610" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006694", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35341" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008206" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0072330" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1901617" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36235" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006706", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006706", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35341" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006810", "pred" : "is_a", @@ -34417,6 +97454,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006869", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006873", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019725" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006873", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_24867" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006886", "pred" : "is_a", @@ -34833,6 +97878,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007034", "pred" : "http://purl.obolibrary.org/obo/RO_0002344", "obj" : "http://purl.obolibrary.org/obo/GO_0005773" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007039", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007039", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0005773" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0007040", "pred" : "is_a", @@ -35277,6 +98330,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007440", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007442", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009653" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007442", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0048546" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007442", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061525" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007442", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0007492", "pred" : "is_a", @@ -35285,6 +98354,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007492", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000925" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007494", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007494", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0007498", "pred" : "is_a", @@ -35393,6 +98470,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007586", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0032501" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007588", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007589", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046903" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007589", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050878" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0007600", "pred" : "is_a", @@ -35409,6 +98498,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007606", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0007600" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007610", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032501" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007610", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007610", + "pred" : "http://purl.obolibrary.org/obo/RO_0002608", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001016" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007626", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007610" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008015", "pred" : "is_a", @@ -35453,6 +98558,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0008152", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008202", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006629" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008202", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35341" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008206", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008206", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032787" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008206", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1901615" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008206", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36235" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008219", "pred" : "is_a", @@ -35485,6 +98614,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0008285", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0008283" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008320", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008320", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140318" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008320", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0071806" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008347", "pred" : "is_a", @@ -35577,6 +98718,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0008643", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008645", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008645", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009056", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009057", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009057", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33694" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009058", "pred" : "is_a", @@ -35609,6 +98770,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009101", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_17089" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009250", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0000271" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009250", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009250", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_37163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009251", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_37163" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009306", "pred" : "is_a", @@ -35637,6 +98818,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009309", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_32952" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009310", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009310", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_32952" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009314", "pred" : "is_a", @@ -35733,6 +98922,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009628", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0050896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009636", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042221" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009653", "pred" : "is_a", @@ -35773,6 +98966,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009743", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009746", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009746", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009749", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009749", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009786", "pred" : "is_a", @@ -35897,6 +99106,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009893", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019222" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009894", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009895", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009892" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009895", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009895", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009896", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009893" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009896", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009896", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009913", "pred" : "is_a", @@ -36289,6 +99530,42 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010564", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0022402" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010565", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010565", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010565", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0042180" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010566", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010566", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031326" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010566", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0042181" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010567", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031329" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010567", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010567", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0042182" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010594", "pred" : "is_a", @@ -36721,6 +99998,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010701", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0048243" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010710", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010710", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0030574" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010711", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010711", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010710" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010711", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0030574" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010712", "pred" : "is_a", @@ -36985,6 +100282,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010820", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0010818" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010827", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034762" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010827", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1904659" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010828", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010827" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010828", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034764" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010828", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1904659" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010829", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010827" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010829", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034763" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010829", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1904659" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010830", "pred" : "is_a", @@ -37041,6 +100370,58 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010876", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010893", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045940" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010893", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010893", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010893", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051055" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010894", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010906", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006109" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010906", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006006" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010907", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010906" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010907", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045913" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010907", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006006" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010927", "pred" : "is_a", @@ -37117,6 +100498,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010948", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0022402" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010962", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032885" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010962", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0009250" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010968", "pred" : "is_a", @@ -37597,6 +100986,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0014819", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0003009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0014821", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0014827", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0014821" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0014827", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0014831" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0014831", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006939" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0014855", "pred" : "is_a", @@ -37789,6 +101194,82 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0015031", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0045184" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015075", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015075", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0034220" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015075", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_24867" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015106", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015106", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0015701" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015106", + "pred" : "http://purl.obolibrary.org/obo/RO_0000057", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17544" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015106", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17544" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015125", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015125", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0015721" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015125", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_3098" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015144", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015144", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0034219" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015144", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015149", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015149", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0008645" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015149", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015159", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0015774" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015159", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18154" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0015629", "pred" : "is_a", @@ -37809,6 +101290,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0015671", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_15379" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015701", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015701", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17544" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015718", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046942" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015718", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006869" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0015718" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0015850" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015721", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_3098" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0015774", "pred" : "is_a", @@ -37837,6 +101350,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0015837", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_32952" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015849", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015849", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0015850", "pred" : "is_a", @@ -37877,10 +101398,34 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0015931", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_61120" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015932", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015932", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0015931" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015932", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_61120" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015980", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006091" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0016020", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0110165" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016042", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016042", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0016043", "pred" : "is_a", @@ -37917,6 +101462,46 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0016051", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016052", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016052", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016053", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006082" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016053", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044249" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016053", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044283" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016053", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016054", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006082" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016054", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016054", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044282" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016054", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0016057", "pred" : "is_a", @@ -38009,6 +101594,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0016528", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/CL_0000187" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016787", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016788", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0016787" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0017126", "pred" : "is_a", @@ -38065,6 +101658,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0018958", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33853" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019098", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007610" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019098", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048609" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019216", "pred" : "is_a", @@ -38073,6 +101674,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0019216", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0006629" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019218", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019216" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019218", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0008202" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019219", "pred" : "is_a", @@ -38121,6 +101730,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0019233", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0007600" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019318", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019318", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019319", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019319", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019320", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019320", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019336", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019336", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33853" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019538", "pred" : "is_a", @@ -38129,6 +101770,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0019538", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/PR_000000001" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019614", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019614", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33566" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019725", "pred" : "is_a", @@ -38141,6 +101790,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0019725", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_131567" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019752", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043436" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019752", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019867", "pred" : "is_a", @@ -39113,6 +102770,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0022618", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_1990904" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022857", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022857", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0055085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022857", + "pred" : "http://purl.obolibrary.org/obo/RO_0002342", + "obj" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022884", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022884", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022898", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032409" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022898", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034762" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022898", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0023019", "pred" : "is_a", @@ -39269,6 +102958,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0030072", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_25905" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030073", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009306" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030073", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030072" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030073", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030073", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000009054" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030097", "pred" : "is_a", @@ -39349,6 +103054,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0030155", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0007155" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030163", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030163", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000000001" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030182", "pred" : "is_a", @@ -39409,6 +103122,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0030213", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16336" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030214", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030214", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16336" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030217", "pred" : "is_a", @@ -39653,6 +103374,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0030397", "pred" : "http://purl.obolibrary.org/obo/RO_0002590", "obj" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030421", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007588" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030421", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022600" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030432", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0014821" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030473", "pred" : "is_a", @@ -39673,6 +103406,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0030485", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/CL_0000192" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030573", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030573", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36235" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030574", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/GO_0005581" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030595", "pred" : "is_a", @@ -39965,6 +103714,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0031012", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0030312" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031016", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048513" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048732" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031016" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0035272" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0055123" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031017", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031018", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031018", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031016" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031018", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0035270" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031018", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000016" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0031022", "pred" : "is_a", @@ -40333,6 +104126,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0031328", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0044249" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031329", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031324" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031329" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031330", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031325" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031329" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031331", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0031333", "pred" : "is_a", @@ -40585,6 +104422,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0031982", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0043227" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031987", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0040011" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031987", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0007626" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050714" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050796" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0090277" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032024", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032057", "pred" : "is_a", @@ -40613,6 +104474,94 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032060", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0032059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032069", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051336" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032069", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060255" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032069", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0004518" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032070", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032069" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032070", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051052" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032070", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0004536" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032074", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032069" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032074", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045934" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032074", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051346" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032074", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0004518" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032075", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032069" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032075", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045935" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032075", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051345" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032075", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0004518" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032070" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032074" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051053" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032076", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0004536" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032070" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032075" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032077", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0004536" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032101", "pred" : "is_a", @@ -40829,6 +104778,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032332", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0002062" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032364", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055082" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032364", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_15379" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032365", "pred" : "is_a", @@ -40969,6 +104926,86 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032388", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0046907" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032409", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0065009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032409", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032410", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032409" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032410", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044092" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032410", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051051" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032410", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032411", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032409" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032411", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044093" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032411", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051050" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032411", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022898" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032412", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0015075" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032410" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032412" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034766" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032413", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0015075" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032414", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032411" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032414", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032412" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032414", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034767" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032414", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0015075" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032418", "pred" : "is_a", @@ -41061,6 +105098,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032774", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33697" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032782", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046717" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032782", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36235" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032787", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019752" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032787", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032790", "pred" : "is_a", @@ -41077,6 +105130,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032838", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0120025" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032868", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042221" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032868", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043434" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032868", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000009054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032869", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032868" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032869", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0071375" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032871", "pred" : "is_a", @@ -41145,6 +105218,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032886", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0007017" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032890", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051049" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032890", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0015849" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032891", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032890" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032891", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051051" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032891", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0015849" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032892", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032890" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032892", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051050" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032892", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0015849" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032940", "pred" : "is_a", @@ -41153,6 +105258,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032940", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0140352" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032941", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032501" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032941", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046903" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032943", "pred" : "is_a", @@ -41501,6 +105614,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0033240", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0009308" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033241", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033241", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0009310" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033242", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033242", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0033241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033242", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0009310" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033243", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033243", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0033241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033243", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0009310" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0033278", "pred" : "is_a", @@ -41549,6 +105694,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0033371", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/CL_0000084" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033500", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033500", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0033604", "pred" : "is_a", @@ -41717,6 +105870,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0034250", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0043603" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034251", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0043605" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034252", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0043605" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034253", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0043605" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0034329", "pred" : "is_a", @@ -41853,6 +106038,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0034654", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_61120" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034655", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034655", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_61120" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0034762", "pred" : "is_a", @@ -42225,6 +106418,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0035592", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0071692" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035622", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035622", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035622", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003704" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035628", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035628", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035645", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051145" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035645", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0048565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035645", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0002504" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0035701", "pred" : "is_a", @@ -42269,6 +106494,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0035767", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0060326" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035773", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035773", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0071333" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035774", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032024" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035774", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061178" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035774", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0035773" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0035779", "pred" : "is_a", @@ -42293,6 +106538,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0035805", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035844", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035844", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001655" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035844", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0048546" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035844", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0035855", "pred" : "is_a", @@ -42577,6 +106838,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0036293", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0070482" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036333", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048872" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036333", + "pred" : "http://purl.obolibrary.org/obo/RO_0012003", + "obj" : "http://purl.obolibrary.org/obo/CL_0000182" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0036334", "pred" : "is_a", @@ -42593,6 +106862,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0036336", "pred" : "http://purl.obolibrary.org/obo/RO_0002565", "obj" : "http://purl.obolibrary.org/obo/CL_0000451" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009653" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036342", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036342", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0036477", "pred" : "is_a", @@ -42961,6 +107242,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042158", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_6495" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042159", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_6495" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042175", "pred" : "is_a", @@ -42969,6 +107258,66 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042175", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0012505" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042176", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042176", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042177", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042177", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042176" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042177", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042180", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044237" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042180", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042180", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042181", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042180" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042181", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044249" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042181", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044283" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042181", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042182", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042182", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044282" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042182", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17087" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042221", "pred" : "is_a", @@ -43013,6 +107362,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042401", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0009309" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042402", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009310" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042415", "pred" : "is_a", @@ -43029,6 +107382,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042421", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_72587" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042422", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042422", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_72587" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042423", "pred" : "is_a", @@ -43037,6 +107398,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042423", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33567" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042424", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042402" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042424", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33567" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042427", "pred" : "is_a", @@ -43065,6 +107434,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042428", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_350546" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042429", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042429", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_350546" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042430", "pred" : "is_a", @@ -43085,6 +107462,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042435", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_24828" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042436", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042436", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_24828" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042461", "pred" : "is_a", @@ -43169,10 +107554,34 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042582", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0030141" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042588", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030141" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042589", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030667" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042589", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0042588" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042589", + "pred" : "http://purl.obolibrary.org/obo/RO_0002007", + "obj" : "http://purl.obolibrary.org/obo/GO_0042588" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042592", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042593", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042593", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042611", "pred" : "is_a", @@ -43225,6 +107634,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042886", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_32988" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042887", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042887", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0042886" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042887", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_32988" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042953", "pred" : "is_a", @@ -43477,10 +107898,58 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0043073", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/CL_0000586" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043085", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044093" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043085", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050790" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043085", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043086", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044092" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043086", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050790" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043086", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043129", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0048871" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043133", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043133", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022600" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043133", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043134", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006940" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043134", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044058" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043134", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0043133" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043143", "pred" : "is_a", @@ -43501,6 +107970,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0043170", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043171", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_60466" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043207", "pred" : "is_a", @@ -43721,6 +108198,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0043434", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_25905" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043436", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006082" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043436", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35406" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043467", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043467", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006091" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043470", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043470", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0016052" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043473", "pred" : "is_a", @@ -43889,6 +108390,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0043604", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_32988" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043605", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043605", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_32988" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043931", "pred" : "is_a", @@ -43913,6 +108422,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0043933", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", "obj" : "http://purl.obolibrary.org/obo/GO_0032991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044042", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044042", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_37163" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044057", "pred" : "is_a", @@ -43937,6 +108454,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0044060", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0050886" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044062", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044062", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051046" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044062", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0007588" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044065", "pred" : "is_a", @@ -44001,6 +108530,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0044091", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044092", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0065009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044092", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0003674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044093", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0065009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044093", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0003674" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044207", "pred" : "is_a", @@ -44021,6 +108566,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0044238", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044248", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044248", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044237" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044249", "pred" : "is_a", @@ -44029,6 +108582,34 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0044249", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0044237" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044258", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0016042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044258", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044282", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044282", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044283", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044283", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044297", "pred" : "is_a", @@ -44037,6 +108618,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0044297", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050673" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044342", + "pred" : "http://purl.obolibrary.org/obo/RO_0012003", + "obj" : "http://purl.obolibrary.org/obo/CL_0000169" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044346", "pred" : "is_a", @@ -44917,6 +109506,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0045687", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0010001" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045719", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005979" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045719", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010558" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045719", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070874" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045719", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0005978" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006111" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031327" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045912" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045721", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006094" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045722", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006111" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045722", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031328" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045722", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006094" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0045724", "pred" : "is_a", @@ -44933,6 +109566,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0045724", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0060271" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045725", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005979" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045725", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010557" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045725", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070875" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045725", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0005978" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0045727", "pred" : "is_a", @@ -44949,6 +109598,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0045727", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0006412" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045732", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045732", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042176" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045732", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0045759", "pred" : "is_a", @@ -45125,6 +109786,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0045807", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0006897" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045818", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005981" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045818", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031330" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045818", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070874" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045818", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0005980" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045819", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005981" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045819", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031331" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045819", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070875" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045819", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0005980" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0045822", "pred" : "is_a", @@ -45505,6 +110198,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0045935", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0006139" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045939", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019218" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045939", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045833" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045939", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0008202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045940", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019218" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045940", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045834" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045940", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0008202" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0045947", "pred" : "is_a", @@ -45629,6 +110346,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0046189", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33853" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0016053" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019752" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046394", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046395", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0016054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046395", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046530", "pred" : "is_a", @@ -45877,6 +110614,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0046673", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0046667" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046676", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050709" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046676", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050796" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046676", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0090278" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046676", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046716", "pred" : "is_a", @@ -46061,6 +110814,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0046907", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/GO_0005622" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046942", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046942", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046943", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046943", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_1905039" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046943", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0047496", "pred" : "is_a", @@ -46613,6 +111386,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0048519", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048520", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050795" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048520", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048520", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0007610" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048521", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050795" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048521", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048521", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0007610" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0048522", "pred" : "is_a", @@ -46645,6 +111442,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0048534", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0002520" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048536", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048534" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048536", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0048539", "pred" : "is_a", @@ -47597,6 +112402,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0048873", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0048872" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048878", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042592" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048878", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0048880", "pred" : "is_a", @@ -48001,6 +112814,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050789", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050790", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0065009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050790", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0050793", "pred" : "is_a", @@ -48017,6 +112838,34 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050794", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0009987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050795", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051239" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050795", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0007610" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050796", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050708" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050796", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0090276" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050796", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050801", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050801", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_24867" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0050803", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", @@ -48081,6 +112930,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050808", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", "obj" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050810", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019218" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050810", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046890" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050810", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006694" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0050832", "pred" : "is_a", @@ -48205,6 +113066,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050886", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0003008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050890", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050877" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0050896", "pred" : "is_a", @@ -48389,6 +113254,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050975", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0050954" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050994", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050994", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0016042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050995", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050995", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050994" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050995", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0016042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050996", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050996", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050994" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050996", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0016042" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051017", "pred" : "is_a", @@ -48409,6 +113306,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0051027", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051033", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051033", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0050658" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051033", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33697" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051035", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051035", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0051027" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051035", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051046", "pred" : "is_a", @@ -48981,6 +113902,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0051321", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2759" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051336", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050790" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051336", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0016787" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051345", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051345", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051336" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051345", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0016787" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051346", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043086" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051346", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051336" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051346", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0016787" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051402", "pred" : "is_a", @@ -48989,6 +113942,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0051402", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/CL_0000540" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051410", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0098754" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051410", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051410", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_51143" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051445", "pred" : "is_a", @@ -49897,6 +114862,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0055059", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0055057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0055082", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019725" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0055082", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0055085", "pred" : "is_a", @@ -49909,6 +114882,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0055085", "pred" : "http://purl.obolibrary.org/obo/RO_0002342", "obj" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0055088", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0055088", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0055094", "pred" : "is_a", @@ -49989,6 +114970,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0055123", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001007" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060021", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007375" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0060037", "pred" : "is_a", @@ -50541,6 +115530,62 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0060341", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0051641" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060343", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060343", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0009887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060343", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061383" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060343", + "pred" : "http://purl.obolibrary.org/obo/RO_0002297", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060344", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060343" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060344", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060344", + "pred" : "http://purl.obolibrary.org/obo/RO_0002297", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010183" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060345", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060343" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060345", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0048536" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060345", + "pred" : "http://purl.obolibrary.org/obo/RO_0002297", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001265" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060343" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060347", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003206" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060347", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061384" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060347", + "pred" : "http://purl.obolibrary.org/obo/RO_0002297", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0060348", "pred" : "is_a", @@ -50909,6 +115954,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0060441", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0060425" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060450", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043134" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060450", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060450", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060456" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060450", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0043133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060451", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043134" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060451", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045986" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060451", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060457" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060451", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0043133" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0060452", "pred" : "is_a", @@ -51401,6 +116478,42 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0060572", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005153" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002069" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060574", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0060576" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060574", + "pred" : "http://purl.obolibrary.org/obo/RO_0002299", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060575", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002065" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060575", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0048565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060575", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060576", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002066" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060576", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0060575" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060576", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0060577", "pred" : "is_a", @@ -51961,6 +117074,66 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0060986", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0050886" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061007", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048731" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061008", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061009", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0035295" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061009", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061009", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061010", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048513" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061010", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061010", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061011", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061011", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030855" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048863" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061017", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061024", "pred" : "is_a", @@ -52381,6 +117554,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061111", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0060684" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061113", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031016" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061113", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061138" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061114", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061113" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061117", "pred" : "is_a", @@ -52393,6 +117586,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061117", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0060419" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061130", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048645" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061130", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061114" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061130", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0072175" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061130", + "pred" : "http://purl.obolibrary.org/obo/RO_0002297", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003922" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061138", "pred" : "is_a", @@ -52449,6 +117658,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061152", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061153", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048732" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061153", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061153", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005203" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061154", "pred" : "is_a", @@ -52481,6 +117702,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061156", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061178", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050796" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061178", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0035773" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061179", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046676" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061179", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048585" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061179", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061178" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061179", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0035773" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061181", "pred" : "is_a", @@ -52673,6 +117918,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061351", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008283" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061383", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009653" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061383", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061384", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061383" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061384", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061385", "pred" : "is_a", @@ -52701,6 +117962,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061450", "pred" : "http://purl.obolibrary.org/obo/RO_0002565", "obj" : "http://purl.obolibrary.org/obo/CL_0000351" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061453", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060563" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061453", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060575" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061453", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0002088" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061458", "pred" : "is_a", @@ -52717,6 +117990,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061462", "pred" : "http://purl.obolibrary.org/obo/RO_0002339", "obj" : "http://purl.obolibrary.org/obo/GO_0005764" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061469", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050678" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061469", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0044342" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061484", "pred" : "is_a", @@ -52769,6 +118050,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061523", "pred" : "http://purl.obolibrary.org/obo/RO_0002590", "obj" : "http://purl.obolibrary.org/obo/GO_0005929" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061525", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061525", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061548", "pred" : "is_a", @@ -52945,6 +118234,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061572", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", "obj" : "http://purl.obolibrary.org/obo/GO_0032432" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061580", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061582" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061580", + "pred" : "http://purl.obolibrary.org/obo/RO_0002565", + "obj" : "http://purl.obolibrary.org/obo/CL_0011108" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061581", "pred" : "is_a", @@ -52953,6 +118250,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061581", "pred" : "http://purl.obolibrary.org/obo/RO_0002565", "obj" : "http://purl.obolibrary.org/obo/CL_0000575" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061582", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010631" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061582", + "pred" : "http://purl.obolibrary.org/obo/RO_0002565", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061626", "pred" : "is_a", @@ -53061,6 +118366,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061973", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007842" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062012", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019222" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062012", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062013", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009893" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062013", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062013", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062014", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009892" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062014", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062014", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0062023", "pred" : "is_a", @@ -53149,6 +118486,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0065007", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0065009", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0065007" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0065009", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0003674" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0065010", "pred" : "is_a", @@ -53345,6 +118690,66 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0070253", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_64628" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070254", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007589" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070254", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032941" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070254", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000912" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070255", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070255", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051046" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070255", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051239" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070255", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0070254" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070256", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051048" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070256", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070256", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070255" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070256", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0070254" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070257", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051047" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070257", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070257", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070255" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070257", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0070254" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0070285", "pred" : "is_a", @@ -53397,6 +118802,58 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0070346", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0070341" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070365", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030855" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070365", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070365", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0000182" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070366", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070366", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0070365" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070367", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070367", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070367", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070366" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070367", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0070365" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070368", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030858" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070368", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070368", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070366" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070368", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0070365" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0070382", "pred" : "is_a", @@ -53505,6 +118962,118 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0070831", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0005604" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070857", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070857", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031326" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070857", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070857", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070857", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070858", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070858", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031327" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070858", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070858", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904252" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070858", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070859", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010893" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070859", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031328" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070859", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070859", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904253" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070859", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070873", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032881" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070873", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043467" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070873", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0005977" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070874", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010605" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070874", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031324" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070874", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045912" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070874", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070873" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070874", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0005977" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070875", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010604" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070875", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010907" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070875", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031325" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070875", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070873" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070875", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0005977" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0070887", "pred" : "is_a", @@ -53565,6 +119134,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0071322", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0070887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0071331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009746" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0071331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0071333", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0001678" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0071333", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009749" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0071333", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070887" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0071375", "pred" : "is_a", @@ -53981,6 +119570,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0071971", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0070062" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072001", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048731" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072001", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001008" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0072089", "pred" : "is_a", @@ -54041,6 +119638,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0072201", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0010463" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072329", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032787" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046394" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072330", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0072359", "pred" : "is_a", @@ -54085,6 +119702,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0072537", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CL_0000057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072560", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002071" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072560", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072560", + "pred" : "http://purl.obolibrary.org/obo/RO_0002299", + "obj" : "http://purl.obolibrary.org/obo/CL_0000169" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072575", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050673" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072575", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0072576" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072576", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022612" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072576", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072576", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0072577", "pred" : "is_a", @@ -54729,6 +120378,58 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0090317", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0006886" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090325", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0040012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090325", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050795" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090325", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0031987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090326", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0040017" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090326", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048520" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090326", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0090325" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090326", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0031987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090327", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0040013" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090327", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048521" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090327", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0090325" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090327", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0031987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090425", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002067" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090425", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0000622" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0090435", "pred" : "is_a", @@ -54825,6 +120526,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0097049", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/CL_0000100" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097050", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904019" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097050", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/CL_0000169" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0097060", "pred" : "is_a", @@ -54893,6 +120602,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0097212", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", "obj" : "http://purl.obolibrary.org/obo/GO_0005765" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097254", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003014" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097254", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007588" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097272", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097272", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_28938" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055082" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0097272" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097284", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904019" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097284", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/CL_0000182" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0097355", "pred" : "is_a", @@ -55209,6 +120950,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0098751", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/CL_0001035" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0098754", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0098754", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0009636" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0098773", "pred" : "is_a", @@ -55265,6 +121014,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0098797", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0005886" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0098801", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0098801", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0003014" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0098813", "pred" : "is_a", @@ -55865,6 +121622,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0099541", "pred" : "http://purl.obolibrary.org/obo/RO_0002608", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099546", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140246" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099546", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0007268" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0099547", "pred" : "is_a", @@ -55921,6 +121686,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0099571", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050804" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140250" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099575", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042176" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099575", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0099171" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099576", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042176" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099576", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0099170" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0099577", "pred" : "is_a", @@ -56221,6 +122010,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0110111", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0009887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032368" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032409" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110112", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0005319" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032370" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032411" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0110112" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110113", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0005319" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032369" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032410" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0110112" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110114", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0005319" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0110116", "pred" : "is_a", @@ -56385,6 +122218,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0120111", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0043005" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120158", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120158", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010710" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120158", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0030574" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120178", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120178", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_26764" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0120186", "pred" : "is_a", @@ -56409,6 +122262,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0120187", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0071168" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120188", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051046" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120188", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0032782" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120189", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051047" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120189", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0120188" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120189", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0032782" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051048" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0120188" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120190", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0032782" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0120222", "pred" : "is_a", @@ -56517,6 +122402,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0140077", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0042953" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140096", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140096", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000000001" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140097", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140097", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140098", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140098", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33697" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140103", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140103", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17089" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0140112", "pred" : "is_a", @@ -56633,6 +122550,70 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0140245", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140246", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140246", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140246", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140246", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36080" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140247", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140246" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140247", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0098793" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140249", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140246" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140249", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140250", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140250", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140250", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140250", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36080" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140250" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140251", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0098793" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140250" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140252", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0098794" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0140253", "pred" : "is_a", @@ -56641,6 +122622,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0140253", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/GO_0045026" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140318", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140318", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000000001" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0140352", "pred" : "is_a", @@ -56701,6 +122690,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0140694", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0043228" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140734", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007588" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140734", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_28938" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140962", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048871" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140962", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0150031", "pred" : "is_a", @@ -56897,6 +122902,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0160093", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0170055", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005319" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0170055", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1900015", "pred" : "is_a", @@ -56929,6 +122942,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1900017", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0002534" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048583" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050794" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900076", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0032869" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048523" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048585" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1900076" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900077", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0032869" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048522" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048584" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1900076" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900078", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0032869" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1900115", "pred" : "is_a", @@ -57189,6 +123246,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1900426", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0042742" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901142", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019538" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901142", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/PR_000009054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901143", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901143", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1901142" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901143", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000009054" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901148", "pred" : "is_a", @@ -57205,6 +123282,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901160", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_50994" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901161", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901161", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_50994" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901162", "pred" : "is_a", @@ -57565,6 +123650,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901564", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901565", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901565", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901566", "pred" : "is_a", @@ -57617,6 +123710,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901615", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33822" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901616", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901616", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33822" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901617", "pred" : "is_a", @@ -57629,6 +123730,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901617", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33822" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901618", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901618", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33822" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901623", "pred" : "is_a", @@ -57673,6 +123782,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901653", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_1901652" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901654", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901654", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901655", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901655", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1901654" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901692", "pred" : "is_a", @@ -58189,6 +124314,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1902340", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0030261" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902369", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902369", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006401" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1902414", "pred" : "is_a", @@ -58225,6 +124358,74 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1902474", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0035418" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902488", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904019" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902488", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902489", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006915" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902489", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/CL_0005026" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902494", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902494", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902495", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0098796" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902495", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1990351" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902495", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902510", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903624" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902510", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006309" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902511", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1902510" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902511", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903625" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902511", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006309" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902512", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1902510" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902512", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903626" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902512", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006309" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1902513", "pred" : "is_a", @@ -58969,6 +125170,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903380", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0007076" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903412", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_3098" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903412" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903429", "pred" : "is_a", @@ -59009,6 +125226,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903441", "pred" : "http://purl.obolibrary.org/obo/RO_0002339", "obj" : "http://purl.obolibrary.org/obo/GO_0060170" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903510", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903510", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_37395" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903522", "pred" : "is_a", @@ -59245,6 +125470,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903569", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_1903441" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903624", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903624", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006308" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903625", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903625", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903624" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903625", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006308" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903626", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903626", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903624" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903626", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006308" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903697", "pred" : "is_a", @@ -59389,6 +125646,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903781", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0061337" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903825", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0015849" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903825", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055085" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903828", "pred" : "is_a", @@ -59517,6 +125782,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903942", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0007585" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903943", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904035" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903943", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0097284" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903944", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903943" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903944", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904036" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903944", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0097284" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903943" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904037" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903945", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0097284" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903950", "pred" : "is_a", @@ -59689,6 +125986,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904037", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_1904019" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904054", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050678" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904054", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1990705" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904055", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050680" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904055", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904055", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1990705" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904056", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050679" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904056", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904056", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1990705" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904057", "pred" : "is_a", @@ -59865,6 +126194,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904179", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0060612" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904192", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904035" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904192", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1902488" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904036" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904192" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904193", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1902488" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904194", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904037" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904194", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904192" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904194", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1902488" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904204", "pred" : "is_a", @@ -59917,6 +126278,62 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904238", "pred" : "http://purl.obolibrary.org/obo/RO_0002315", "obj" : "http://purl.obolibrary.org/obo/CL_0000669" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019218" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904251", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0008206" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031324" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062014" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904252", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0008206" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031325" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045940" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062013" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904253", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0008206" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904269", "pred" : "is_a", @@ -59925,6 +126342,70 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904269", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0031252" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904304", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006940" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904304", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0014831" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904305", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045986" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904305", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904304" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904305", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0014831" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904306", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904306", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904304" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904306", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0014831" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904341", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904304" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904341", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1990765" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904305" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904341" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904342", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1990765" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904343", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904306" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904343", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904341" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904343", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1990765" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904344", "pred" : "is_a", @@ -59957,6 +126438,70 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904346", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_1990768" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904304" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904347", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1990770" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904348", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904305" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904348", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904347" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904348", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1990770" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904349", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904306" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904349", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904347" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904349", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1990770" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904350", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042176" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904350", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0007039" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904351", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042177" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904351", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904350" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904351", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0007039" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904352", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045732" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904352", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904350" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904352", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0007039" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904375", "pred" : "is_a", @@ -60125,6 +126670,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904457", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0019228" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904484", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048732" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904484", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012478" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904491", "pred" : "is_a", @@ -60229,6 +126782,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904655", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0048286" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904659", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904659", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904675", "pred" : "is_a", @@ -60261,6 +126822,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904677", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0048103" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904680", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904680", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_60466" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904691", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050680" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904691", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061469" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904691", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0044342" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904692", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050679" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904692", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061469" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904692", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0044342" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904693", "pred" : "is_a", @@ -60277,6 +126870,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904693", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001891" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904697", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050678" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904697", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1990863" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904698", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050680" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904698", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904697" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904698", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1990863" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050679" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904697" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904699", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1990863" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904705", "pred" : "is_a", @@ -60685,6 +127310,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904989", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0042118" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905039", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046942" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905039", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055085" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1905063", "pred" : "is_a", @@ -60805,6 +127438,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1905142", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_1905139" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905146", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007039" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905146", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0005764" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1905147", "pred" : "is_a", @@ -60881,6 +127522,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1905155", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0010324" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905165", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904350" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905165", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1905146" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905166", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904351" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905166", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1905165" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905166", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1905146" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905167", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904352" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905167", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1905165" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905167", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1905146" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1905207", "pred" : "is_a", @@ -61061,6 +127734,54 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1905294", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0014033" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905298", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905298", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060284" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905298", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0060576" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905299", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010721" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905299", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905299", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905299", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1905298" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905299", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0060576" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905300", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010720" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905300", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905300", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1905298" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905300", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0060576" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1905304", "pred" : "is_a", @@ -62345,6 +129066,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1990280", "pred" : "http://purl.obolibrary.org/obo/RO_0002339", "obj" : "http://purl.obolibrary.org/obo/GO_0000785" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990351", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990351", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1990502", "pred" : "is_a", @@ -62353,6 +129082,46 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1990502", "pred" : "http://purl.obolibrary.org/obo/RO_0002299", "obj" : "http://purl.obolibrary.org/obo/GO_0031045" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990705", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050673" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990705", + "pred" : "http://purl.obolibrary.org/obo/RO_0012003", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990748", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990748", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0098754" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990748", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0097237" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990748", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990765", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990765", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0014827" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990765", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990765", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1990768", "pred" : "is_a", @@ -62361,6 +129130,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1990768", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004786" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990770", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990770", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0014827" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990770", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990770", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1990778", "pred" : "is_a", @@ -62377,6 +129162,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1990849", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/GO_0005773" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990863", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050673" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990863", + "pred" : "http://purl.obolibrary.org/obo/RO_0012003", + "obj" : "http://purl.obolibrary.org/obo/CL_0000622" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1990874", "pred" : "is_a", @@ -62437,6 +129230,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000068", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0002213" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000074", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060284" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000074", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0003323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010721" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000074" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000077", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0003323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010720" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030858" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000074" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000078", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0003323" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000106", "pred" : "is_a", @@ -62757,6 +129594,46 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000196", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0008585" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000226", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000226", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0003310" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000226" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000227", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0003310" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000228", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030858" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000228", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000228", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000226" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000228", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0003310" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000241", "pred" : "is_a", @@ -62897,6 +129774,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000291", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0051450" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044058" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044062" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000292", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0030421" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051048" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060457" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000292" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000293", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0030421" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000294", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051047" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000294", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060456" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000294", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000292" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000294", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0030421" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000351", "pred" : "is_a", @@ -63385,6 +130306,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000673", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0097049" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000674", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904035" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000674", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0097050" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000675", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904036" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000675", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000675", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0097050" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000676", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904037" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000676", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000676", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0097050" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000690", "pred" : "is_a", @@ -63681,6 +130634,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000836", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0035935" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2001012", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048762" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2001012", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0072001" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2001014", "pred" : "is_a", @@ -64033,6 +130994,10 @@ "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_142796", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2605435" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1437010", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_9347" }, { "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1437180", "pred" : "is_a", @@ -64073,6 +131038,10 @@ "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2058949", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33083" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_207598", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_9604" }, { "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2157", "pred" : "is_a", @@ -64097,6 +131066,18 @@ "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2759", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_131567" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_314146", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_1437010" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_314293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_376913" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_314295", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_9526" }, { "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_3176", "pred" : "is_a", @@ -64185,6 +131166,10 @@ "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_35493", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_376913", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_9443" }, { "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_38254", "pred" : "is_a", @@ -64341,6 +131326,50 @@ "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_89593", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32525" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9443", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_314146" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9526", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_314293" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9604", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_314295" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9605", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_207598" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9606", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_9605" + }, { + "sub" : "http://purl.obolibrary.org/obo/SO_0000001", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000110" + }, { + "sub" : "http://purl.obolibrary.org/obo/SO_0000704", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0001411" + }, { + "sub" : "http://purl.obolibrary.org/obo/SO_0000704", + "pred" : "http://purl.obolibrary.org/obo/so#member_of", + "obj" : "http://purl.obolibrary.org/obo/SO_0005855" + }, { + "sub" : "http://purl.obolibrary.org/obo/SO_0001411", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000001" + }, { + "sub" : "http://purl.obolibrary.org/obo/SO_0005855", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0001411" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000005", "pred" : "is_a", @@ -64357,6 +131386,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000005", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0007606" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000016" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000172" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0002067" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000016" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000009", "pred" : "is_a", @@ -64417,6 +131474,86 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000015", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000466" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000471" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000949" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003923" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0070091" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0070253" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001263" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007329" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/RO_0002216", + "obj" : "http://purl.obolibrary.org/obo/GO_0007586" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000018", "pred" : "is_a", @@ -64625,6 +131762,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000058", "pred" : "http://purl.obolibrary.org/obo/RO_0002570", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000463" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004907" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000060", "pred" : "is_a", @@ -65229,10 +132390,90 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000158", "pred" : "http://purl.obolibrary.org/obo/RO_0002007", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004111" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001245" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011272" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channel_for", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001988" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000160", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000160", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001007" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000161", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004111" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000162", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013522" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000162", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000162", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004122" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000162", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001008" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012361" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003064" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000165", "pred" : "is_a", @@ -65273,6 +132514,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000167", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000170", "pred" : "is_a", @@ -65305,6 +132558,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000171", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0007585" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000174", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000463" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000174", + "pred" : "http://purl.obolibrary.org/obo/RO_0002353", + "obj" : "http://purl.obolibrary.org/obo/GO_0007588" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000178", "pred" : "is_a", @@ -65341,6 +132602,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000179", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002514" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008907" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010428" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011164" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001697" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002217" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015212" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011138" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000126", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001092" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001676" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000304", "pred" : "is_a", @@ -65369,6 +132678,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000307", "pred" : "http://purl.obolibrary.org/obo/RO_0002491", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000317", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001207" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000317", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000320", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001204" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000320", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000325", "pred" : "is_a", @@ -65381,6 +132706,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000325", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000326", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000326", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000328", "pred" : "is_a", @@ -65401,6 +132734,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000332", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/CL_0000136" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000333", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000333", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000344", "pred" : "is_a", @@ -65561,6 +132902,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000390", "pred" : "http://purl.obolibrary.org/obo/RO_0002219", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000389" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000397", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001278" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000397", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000409", "pred" : "is_a", @@ -65589,6 +132938,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000410", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002365" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000319" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0070254" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "pred" : "http://purl.obolibrary.org/obo/RO_0003000", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000912" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000415", "pred" : "is_a", @@ -65597,6 +132962,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000415", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000440", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000440", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002384" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000440", + "pred" : "http://purl.obolibrary.org/obo/RO_0000086", + "obj" : "http://purl.obolibrary.org/obo/PATO_0001873" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000456", "pred" : "is_a", @@ -65657,6 +133034,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000468", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010000" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000471", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000471", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003103" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000474", "pred" : "is_a", @@ -65773,6 +133158,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000490", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006314" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_37395" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "pred" : "http://purl.obolibrary.org/obo/RO_0000086", + "obj" : "http://purl.obolibrary.org/obo/PATO_0000998" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000344" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000915", "pred" : "is_a", @@ -65869,6 +133274,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000930", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0016566" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007026" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "http://purl.obolibrary.org/obo/RO_0001025", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012469" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000945", "pred" : "is_a", @@ -66365,6 +133794,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001007", "pred" : "http://purl.obolibrary.org/obo/RO_0002492", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000066" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8450002" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0097254" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "pred" : "http://purl.obolibrary.org/obo/RO_0002492", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000066" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001009", "pred" : "is_a", @@ -66549,6 +133994,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001043", "pred" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001045", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001045", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001046", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001046", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001046", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001048", "pred" : "is_a", @@ -66577,6 +134042,58 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001049", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005068" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012361" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000025" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007329" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channel_for", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001970" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_into", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004913" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001068", "pred" : "is_a", @@ -66625,6 +134142,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001072", "pred" : "http://purl.obolibrary.org/obo/RO_0002179", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000154" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410024" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001074", "pred" : "is_a", @@ -66737,6 +134270,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001090", "pred" : "http://purl.obolibrary.org/obo/RO_0003001", "obj" : "http://purl.obolibrary.org/obo/CL_0000214" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001092", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001092", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000096", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001093" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001093", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001093", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#anteriorly_connected_to", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001092" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001095", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001095", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004247" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001095", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018142" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001096", "pred" : "is_a", @@ -66765,6 +134326,46 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001103", "pred" : "http://purl.obolibrary.org/obo/RO_0002495", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010084" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001113", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001115", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011138" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#protects", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002240" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001133", "pred" : "is_a", @@ -66837,6 +134438,46 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001137", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005617" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005806" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001639" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005487" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006877" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "pred" : "http://purl.obolibrary.org/obo/RO_0002376", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001145", "pred" : "is_a", @@ -66853,6 +134494,102 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001145", "pred" : "http://purl.obolibrary.org/obo/RO_0002179", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000992" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005604" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_into", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001155", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001155", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001155", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001155", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001161", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009870" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009870" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000502" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000508" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009870" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008858" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008861" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001167", "pred" : "is_a", @@ -66865,6 +134602,170 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001167", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001168", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001168", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001169", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001169", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001170", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001206" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001170", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001170", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007826" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001171", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011858" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001171" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002294" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001246" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001282" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001174", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001174", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001174", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001174", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_into", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005604" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001176" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "http://purl.obolibrary.org/obo/RO_0002495", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010081" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_into", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001176", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001176", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005171" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001176", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001177", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001177", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005171" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001177", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001178", "pred" : "is_a", @@ -66909,6 +134810,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001190", "pred" : "http://purl.obolibrary.org/obo/RO_0002178", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000992" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001193", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001194", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001194", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001194", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001640" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001199", "pred" : "is_a", @@ -66949,6 +134870,262 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001201", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001167" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008858" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001204", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001204", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001204", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001205", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009566" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001205", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001206", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001243" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001206", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001206", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001243" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001207", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001207", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001207", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001208", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009566" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001208", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001209", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001243" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001209", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001209", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001243" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011148" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "pred" : "http://purl.obolibrary.org/obo/RO_0001025", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003332" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_40674" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001213", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004923" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001213", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001213", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001981" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001213", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012425" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001215", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005617" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001215", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001215", + "pred" : "http://purl.obolibrary.org/obo/RO_0002376", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003713" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001238", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004780" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001238", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001204" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001242", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004786" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001242", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001243", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004782" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001243", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000931" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003704" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001279" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004058" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014719" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001279" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001262", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000328" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001262", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013232" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007324" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/CL_0002064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000016" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003923" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001265", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001265", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001265", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1000024" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001268", "pred" : "is_a", @@ -66989,6 +135166,158 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001276", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001199" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000485" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003350" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004808" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001278", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001278", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001207" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001172" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003704" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001171" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008835" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003909" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006877" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006841" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "http://purl.obolibrary.org/obo/RO_0002226", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003704" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014716" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001172" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000182" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001353", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001353", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001353", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000931" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001366", "pred" : "is_a", @@ -67397,6 +135726,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001606", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001606" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004234" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007521" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002346" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "http://purl.obolibrary.org/obo/RO_0002372", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "http://purl.obolibrary.org/obo/RO_0002373", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "http://purl.obolibrary.org/obo/RO_0002568", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001608" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004234" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002346" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "pred" : "http://purl.obolibrary.org/obo/RO_0002372", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "pred" : "http://purl.obolibrary.org/obo/RO_0002373", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "pred" : "http://purl.obolibrary.org/obo/RO_0002568", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001607" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001612", "pred" : "is_a", @@ -67441,6 +135818,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001638", "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_from", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001982" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001639", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001639", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010194" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001639", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001639", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_into", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012254" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001645", "pred" : "is_a", @@ -67557,6 +135970,94 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001676", "pred" : "http://purl.obolibrary.org/obo/RO_0002221", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003687" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002513" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003462" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015060" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008895" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002513" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003462" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011164" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002517" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006227" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011156" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015212" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004088" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011156" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000126", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011156" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "http://purl.obolibrary.org/obo/RO_0001015", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000019" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001703", "pred" : "is_a", @@ -67609,6 +136110,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001708", "pred" : "http://purl.obolibrary.org/obo/RO_0002576", "obj" : "http://purl.obolibrary.org/obo/UBERON_0011595" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010314" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004089" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011595" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "pred" : "http://purl.obolibrary.org/obo/RO_0002551", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003277" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001710", "pred" : "is_a", @@ -68105,6 +136626,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001833", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001834", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001833" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001834", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001709" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001834", + "pred" : "http://purl.obolibrary.org/obo/RO_0002495", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011592" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001835", "pred" : "is_a", @@ -68213,6 +136746,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001901", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001902", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001902", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001204" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001902", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000164" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001915", "pred" : "is_a", @@ -68365,6 +136910,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001969", "pred" : "http://purl.obolibrary.org/obo/RO_0002221", "obj" : "http://purl.obolibrary.org/obo/CL_0000232" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006314" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16990" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_22868" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/RO_0000086", + "obj" : "http://purl.obolibrary.org/obo/PATO_0001735" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/RO_0002216", + "obj" : "http://purl.obolibrary.org/obo/GO_0007586" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001971", "pred" : "is_a", @@ -68413,6 +136990,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001976", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001978", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001978", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001979", "pred" : "is_a", @@ -68541,6 +137126,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001986", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/CL_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001988", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001988", + "pred" : "http://purl.obolibrary.org/obo/RO_0002353", + "obj" : "http://purl.obolibrary.org/obo/GO_0030421" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001994", "pred" : "is_a", @@ -68605,6 +137198,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002016", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005806" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002020", "pred" : "is_a", @@ -68633,6 +137234,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002028", "pred" : "http://purl.obolibrary.org/obo/RO_0002495", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000485" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034932" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002031", "pred" : "is_a", @@ -69069,6 +137690,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002094", "pred" : "http://purl.obolibrary.org/obo/RO_0002220", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002084" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002095", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002095", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002097", "pred" : "is_a", @@ -69133,6 +137762,138 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002105", "pred" : "http://purl.obolibrary.org/obo/RO_0002216", "obj" : "http://purl.obolibrary.org/obo/GO_0007605" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005057" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0017672" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006293" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002365" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005172" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006925" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002405" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008836" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0003000", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001970" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#site_of", + "obj" : "http://purl.obolibrary.org/obo/GO_0002384" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#site_of", + "obj" : "http://purl.obolibrary.org/obo/GO_0005978" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#site_of", + "obj" : "http://purl.obolibrary.org/obo/GO_0005980" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0017672" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018707" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002294" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002111", "pred" : "is_a", @@ -69157,6 +137918,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002112", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0001106", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002118", "pred" : "is_a", @@ -69601,6 +138382,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002275", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002298" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011216" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0015721" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002296", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002296", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009664" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002296", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002298", "pred" : "is_a", @@ -69893,6 +138706,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002346", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/CL_0000133" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003827" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004247" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015008" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013507" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002348", "pred" : "is_a", @@ -70245,6 +139078,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002390", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000025" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003928" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008835" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channel_for", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001970" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008001" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011597" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012071" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011085" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011156" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002400", "pred" : "is_a", @@ -70417,6 +139298,58 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002410", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001016" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002513" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008001" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011094" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003458" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004247" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004451" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015007" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013505" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002415", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011676" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002415", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000154" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002415", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002416", "pred" : "is_a", @@ -70481,6 +139414,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002419", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002097" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011216" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001007" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002294" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0061007" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/RO_0002492", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000066" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002424", "pred" : "is_a", @@ -70545,6 +139506,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002458", "pred" : "http://purl.obolibrary.org/obo/RO_0002178", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002240" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002466", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002466", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002469", "pred" : "is_a", @@ -70585,6 +139554,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002506", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002511", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002511", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002511", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002082" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002511", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001133" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002513", "pred" : "is_a", @@ -70617,6 +139602,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002514", "pred" : "http://purl.obolibrary.org/obo/RO_0002353", "obj" : "http://purl.obolibrary.org/obo/GO_0001957" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002517", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002517", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002517", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002517", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003128" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002521", "pred" : "is_a", @@ -70685,6 +139686,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002532", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/CL_0000352" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002533", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002533", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002536", "pred" : "is_a", @@ -70745,6 +139754,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002553", "pred" : "http://purl.obolibrary.org/obo/RO_0001015", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000463" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002558", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002553" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002561", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002558" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002561", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002561", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001017" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002616", "pred" : "is_a", @@ -71237,6 +140262,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003084", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007005" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003524" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_2001073" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005805" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003089", "pred" : "is_a", @@ -71305,6 +140346,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003104", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/CL_0008019" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003112", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003112", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002241" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003113", "pred" : "is_a", @@ -71441,6 +140494,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003218", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000992" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003235", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0035037" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003235", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001709" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003236", "pred" : "is_a", @@ -71477,6 +140538,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003258", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0015833" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003259", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003259", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003352" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003259", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003260", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003260", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003260", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003269", "pred" : "is_a", @@ -71489,6 +140574,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003269", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000019" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001708" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001709" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "pred" : "http://purl.obolibrary.org/obo/RO_0002576", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001709" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003278", "pred" : "is_a", @@ -71525,6 +140630,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003279", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001986" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003281", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003281", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003282", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003282", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000948" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003283", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001975" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003283", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003284", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003284", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003294", "pred" : "is_a", @@ -71609,6 +140750,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003316", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001040" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034995" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001709" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009526" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003324", "pred" : "is_a", @@ -71621,6 +140778,66 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003324", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006905" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001208" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003329", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001208" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003330", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001208" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003331", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003332", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001205" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003332", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003334", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001209" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003334", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003335", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001209" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003335", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003336", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001206" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003336", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003338", "pred" : "is_a", @@ -71641,6 +140858,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003339", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001207" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003342", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003343", "pred" : "is_a", @@ -71649,6 +140878,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003343", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003346", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001207" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003346", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003350", "pred" : "is_a", @@ -71677,6 +140914,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003351", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007690" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003352", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003352", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003353", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003353", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003354", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001278" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003354", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0016885" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003354", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003364", "pred" : "is_a", @@ -71825,6 +141090,50 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003390", "pred" : "http://purl.obolibrary.org/obo/RO_0001025", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002402" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003393", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003393", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001008" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003394", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003395", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003334" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003395", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003335" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007826" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003397", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001170" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003397", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003336" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003406", "pred" : "is_a", @@ -71905,6 +141214,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003443", "pred" : "http://purl.obolibrary.org/obo/RO_0001025", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002224" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003452", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018649" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003452", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003457", "pred" : "is_a", @@ -71949,6 +141266,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003469", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003643" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003496" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009657" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001834" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001612" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003471", "pred" : "is_a", @@ -71981,6 +141314,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003476", "pred" : "http://purl.obolibrary.org/obo/RO_0002179", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001004" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003477", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013136" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003477", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001834" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003478", "pred" : "is_a", @@ -71997,6 +141338,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003479", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003519" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003524" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003489", "pred" : "is_a", @@ -72181,6 +141530,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003519", "pred" : "http://purl.obolibrary.org/obo/RO_0001025", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002224" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003524", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001981" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003524", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003526", "pred" : "is_a", @@ -72197,6 +141554,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003528", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000955" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003534", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000014" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003534", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003536", "pred" : "is_a", @@ -72361,6 +141726,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003593", "pred" : "http://purl.obolibrary.org/obo/RO_0001025", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002224" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003599", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002384" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003599", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003601", "pred" : "is_a", @@ -72533,6 +141906,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003643", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003509" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003665", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004518" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003665", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003665", + "pred" : "http://purl.obolibrary.org/obo/RO_0002371", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001095" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003684", "pred" : "is_a", @@ -72557,6 +141942,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003687", "pred" : "http://purl.obolibrary.org/obo/RO_0002570", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001896" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000982" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011138" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001092" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001093" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003697", "pred" : "is_a", @@ -72565,6 +141966,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003697", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000916" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003703", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003704", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003704", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003704", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003711", "pred" : "is_a", @@ -72577,6 +141994,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003711", "pred" : "http://purl.obolibrary.org/obo/RO_0002170", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001585" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003713", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003713", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001639" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003714", "pred" : "is_a", @@ -72881,6 +142306,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003891", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002384" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000485" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009550" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003898", "pred" : "is_a", @@ -72937,6 +142394,82 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003920", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004582" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007026" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000925" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007499" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003923", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003923", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010375" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003923", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003924", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003924", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010376" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003924", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008835" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003928", "pred" : "is_a", @@ -73097,6 +142630,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004022", "pred" : "http://purl.obolibrary.org/obo/RO_0002220", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003842" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000025" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004060", "pred" : "is_a", @@ -73197,6 +142750,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004064", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004066", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009292" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004066", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0005001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004068", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009292" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004068", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004066" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004068", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000126", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008816" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004068", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004066" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004087", "pred" : "is_a", @@ -73213,6 +142790,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004088", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004089", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001444" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004089", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004089", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004089", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001456" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004111", "pred" : "is_a", @@ -73257,6 +142850,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004121", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000990" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001008" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "pred" : "http://purl.obolibrary.org/obo/RO_0002492", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000066" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004123", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005983" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004123", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002349" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004123", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#layer_part_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002349" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004124", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004123" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004124", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004124", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/GO_0036194" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004126", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004124" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004126", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001083" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004128", "pred" : "is_a", @@ -73489,6 +143130,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004215", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001137" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004220", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004221" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004220", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004220", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011198" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004226" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012367" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004222", "pred" : "is_a", @@ -73513,6 +143182,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004226", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004231", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004231", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004233", "pred" : "is_a", @@ -73553,6 +143230,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004237", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001981" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004238", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004238", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004239", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004221" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004239", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004239", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011201" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004240", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004240", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004240", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004242", "pred" : "is_a", @@ -73909,6 +143618,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004375", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0011582" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004451", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004451", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000096", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001095" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004455", "pred" : "is_a", @@ -73969,6 +143686,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004465", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000974" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004468", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001015" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004468", + "pred" : "http://purl.obolibrary.org/obo/RO_0002371", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004469", "pred" : "is_a", @@ -74077,6 +143802,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004517", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/CL_4033017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004518", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014892" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004518", + "pred" : "http://purl.obolibrary.org/obo/RO_0002371", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004521", "pred" : "is_a", @@ -74093,6 +143826,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004522", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002204" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004525", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003381" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004525", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003452" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004525", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006570" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004526", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003382" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004526", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003452" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004526", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006571" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004535", "pred" : "is_a", @@ -74181,6 +143938,10 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004582", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004590", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001630" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004638", "pred" : "is_a", @@ -74189,6 +143950,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004638", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001981" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000182" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004663", "pred" : "is_a", @@ -74501,6 +144282,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004756", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002067" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004760", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004760", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004760", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004761", "pred" : "is_a", @@ -74609,6 +144402,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004780", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004786" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004781", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000030" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004781", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004781", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005033" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004782", "pred" : "is_a", @@ -74617,6 +144422,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004782", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004783", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004783", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004783", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004784", "pred" : "is_a", @@ -74661,6 +144478,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004786", "pred" : "http://purl.obolibrary.org/obo/RO_0002220", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006909" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004790", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000414" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004790", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007771" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004790", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0019319" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004792", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004795" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004792", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000016" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004793", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004795" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004793", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004794", "pred" : "is_a", @@ -74669,6 +144514,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004794", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004795", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004795", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004797", "pred" : "is_a", @@ -74725,6 +144578,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004815", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001558" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034932" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034969" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004821", "pred" : "is_a", @@ -74749,6 +144622,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004821", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002299" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004822", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004820" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004822", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004823", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004820" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004823", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003704" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004830", "pred" : "is_a", @@ -74765,6 +144654,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004831", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003832" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004832", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001134" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004832", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004833", "pred" : "is_a", @@ -74773,6 +144670,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004833", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001833" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004834", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004834", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004834", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005171" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004848", "pred" : "is_a", @@ -74817,6 +144726,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004852", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004535" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004854", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004854", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004782" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004857", "pred" : "is_a", @@ -74861,6 +144778,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004864", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000966" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004867", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002553" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004867", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001697" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004872", "pred" : "is_a", @@ -74993,6 +144918,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004906", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004907", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004907", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004907", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004908", "pred" : "is_a", @@ -75021,6 +144958,74 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004911", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000992" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007499" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004913", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004913", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004913", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004914" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004914", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034944" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004914", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000320" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004915", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004915", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004915", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004916", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004916", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004916", + "pred" : "http://purl.obolibrary.org/obo/RO_0002216", + "obj" : "http://purl.obolibrary.org/obo/GO_0030421" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004921", "pred" : "is_a", @@ -75057,6 +145062,90 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004924", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004926", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004938" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004926", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004932", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003331" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004932", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004934", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001200" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004934", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004936", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004937" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004936", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004937", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001200" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004937", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004938", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000009" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004938", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004938", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004939", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004938" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004939", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004940", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004938" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004940", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004941", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004938" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004941", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001176" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004942", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004938" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004942", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001177" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004952", "pred" : "is_a", @@ -75069,6 +145158,102 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004952", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002186" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004988", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004999" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004988", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004993", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000317" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004993", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004995", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001199" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004995", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004997", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004998" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004997", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004997", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004998" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004998", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001199" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004998", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004999", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000344" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004999", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004999", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005000", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004999" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005000", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005001", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004999" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005001", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005002", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004999" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005002", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001176" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005003", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004999" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005003", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005031", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0036294" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005031", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001834" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005032", "pred" : "is_a", @@ -75077,6 +145262,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005032", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001835" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005033", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000344" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005033", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005033", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005039", "pred" : "is_a", @@ -75165,6 +145362,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005062", "pred" : "http://purl.obolibrary.org/obo/BSPO_0000126", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005064", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003382" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005066", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005066", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003381" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005068", "pred" : "is_a", @@ -75273,6 +145486,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005169", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005172", "pred" : "is_a", @@ -75333,6 +145558,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005194", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003834" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005203", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005203", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005221", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005221", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005222", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005233", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005233", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014702" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005233", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004068" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005234", "pred" : "is_a", @@ -75665,6 +145926,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005434", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_8287" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005436", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004573" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005436", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001640" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013685" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001677" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "pred" : "http://purl.obolibrary.org/obo/RO_0002570", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000377" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005460", "pred" : "is_a", @@ -75821,6 +146106,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005598", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002100" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005602", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003281" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005602", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002296" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005602", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003281" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005604", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005604", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005604", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005171" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005613", "pred" : "is_a", @@ -75845,6 +146154,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005614", "pred" : "http://purl.obolibrary.org/obo/RO_0002220", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001804" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005616", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012254" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005616", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005617", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005617", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005622", "pred" : "is_a", @@ -75865,6 +146190,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005631", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0016887" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005637", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001276" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005637", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005638", "pred" : "is_a", @@ -75929,6 +146262,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005673", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003365" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005685", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002296" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005685", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005688", "pred" : "is_a", @@ -75961,6 +146302,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005702", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004348" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003397" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011642" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003284" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003397" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011642" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005720", "pred" : "is_a", @@ -76145,10 +146518,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005805", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005806", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005844", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001948" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005845", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005844" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005845", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006071" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005856", "pred" : "is_a", @@ -76217,6 +146602,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005867", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007237" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005868", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005868", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007238" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005902", "pred" : "is_a", @@ -76261,6 +146654,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005944", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001434" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003932" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005945", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003112" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005946", "pred" : "is_a", @@ -76361,6 +146766,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005985", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000948" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002302" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004124" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002302" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005989", "pred" : "is_a", @@ -76417,6 +146842,94 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006056", "pred" : "http://purl.obolibrary.org/obo/BSPO_0000122", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006068", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001474" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006068", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006071", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011676" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006071", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000154" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006071", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000099", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001245" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006071", + "pred" : "http://purl.obolibrary.org/obo/RO_0002551", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006076" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002090" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012477" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005434" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008231" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014477" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000915" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002090" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006071" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006071" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001137" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006207", "pred" : "is_a", @@ -76473,6 +146986,50 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006218", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002081" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002517" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001679" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1100000" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006236", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006236", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000209" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006238", "pred" : "is_a", @@ -76525,6 +147082,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006241", "pred" : "http://purl.obolibrary.org/obo/RO_0002387", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002240" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006264", "pred" : "is_a", @@ -76573,6 +147150,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006268", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006271", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006271", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013685" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006271", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001697" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006279", "pred" : "is_a", @@ -76613,6 +147202,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006283", "pred" : "http://purl.obolibrary.org/obo/RO_0002387", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002082" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005602" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004872" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006304", "pred" : "is_a", @@ -76757,6 +147374,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006538", "pred" : "http://purl.obolibrary.org/obo/RO_0003001", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001004" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006555", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000025" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006555", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001008" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006562", "pred" : "is_a", @@ -76797,6 +147422,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006567", "pred" : "http://purl.obolibrary.org/obo/RO_0002150", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006563" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006570", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006570", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002080" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006571", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006571", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002084" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410024" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000931" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006595", "pred" : "is_a", @@ -76861,6 +147522,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006603", "pred" : "http://purl.obolibrary.org/obo/RO_0002387", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000926" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006660", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018260" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006660", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006660", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000009" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006670", "pred" : "is_a", @@ -76893,6 +147566,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006677", "pred" : "http://purl.obolibrary.org/obo/RO_0002007", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006686", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006686", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006761", "pred" : "is_a", @@ -76937,6 +147618,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006815", "pred" : "http://purl.obolibrary.org/obo/uberon/core#protects", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006828", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006828", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002081" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006833", "pred" : "is_a", @@ -76969,6 +147658,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006834", "pred" : "http://purl.obolibrary.org/obo/uberon/core#site_of", "obj" : "http://purl.obolibrary.org/obo/GO_0009790" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006841", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006841", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006841", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006846", "pred" : "is_a", @@ -76977,6 +147678,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006846", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0002255" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006866", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006866", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001245" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006866", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006876", "pred" : "is_a", @@ -76985,6 +147698,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006876", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006877", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002201" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006877", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006876" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006877", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006904", "pred" : "is_a", @@ -77265,6 +147990,70 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007135", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007144", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007144", + "pred" : "http://purl.obolibrary.org/obo/RO_0002494", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002533" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007147", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007147", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007147", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007148", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007148", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007148", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007158", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007158", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007158", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007159", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007177", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011189" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007177", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000317" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007188", "pred" : "is_a", @@ -77357,6 +148146,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007237", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004362" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007238", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007238", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004362" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007239", "pred" : "is_a", @@ -77613,6 +148410,58 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007304", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000026" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001263" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014719" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003928" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007375", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007375", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007376", "pred" : "is_a", @@ -77721,6 +148570,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007503", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007521", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007521", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000192" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007521", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007522", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007522", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000737" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007522", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002036" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007524", "pred" : "is_a", @@ -77809,6 +148682,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007651", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007652", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003832" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007652", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007688", "pred" : "is_a", @@ -77913,6 +148794,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007811", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006562" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002415" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006071" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "pred" : "http://purl.obolibrary.org/obo/RO_0002216", + "obj" : "http://purl.obolibrary.org/obo/GO_0007626" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "pred" : "http://purl.obolibrary.org/obo/RO_0002494", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007144" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007823", "pred" : "is_a", @@ -77929,6 +148830,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007823", "pred" : "http://purl.obolibrary.org/obo/RO_0002551", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010719" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007826", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007826", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002358" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007826", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001178" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007828", "pred" : "is_a", @@ -78021,6 +148934,10 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007914", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007811" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008001", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001474" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008114", "pred" : "is_a", @@ -78045,6 +148962,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0008115", "pred" : "http://purl.obolibrary.org/obo/RO_0002007", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007844" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001474" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008193", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010528" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008196", "pred" : "is_a", @@ -78101,6 +149026,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0008339", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_8410081" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008342", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000320" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008346", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013636" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008346", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008342" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008397", "pred" : "is_a", @@ -78173,6 +149114,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0008826", "pred" : "http://purl.obolibrary.org/obo/RO_0003001", "obj" : "http://purl.obolibrary.org/obo/CL_0002063" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007499" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003894" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007499" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008835" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008851", "pred" : "is_a", @@ -78185,6 +149174,70 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0008851", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004364" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018261" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034933" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004222" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001167" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009870" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001202" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000325" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000414" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004998" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "pred" : "http://purl.obolibrary.org/obo/RO_0000086", + "obj" : "http://purl.obolibrary.org/obo/PATO_0002299" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008870", "pred" : "is_a", @@ -78333,6 +149386,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0008951", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005178" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011148" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "pred" : "http://purl.obolibrary.org/obo/RO_0001025", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001972" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008998", "pred" : "is_a", @@ -78469,6 +149542,62 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009145", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014387" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015060" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003932" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005863" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014387" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015060" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009191" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009196", "pred" : "is_a", @@ -78477,6 +149606,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009196", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009204", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009501" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009204", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004068" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012314" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009479", "pred" : "is_a", @@ -78493,6 +149634,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009480", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006211" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009482", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009482", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006235" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009483", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009483", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006235" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009494", "pred" : "is_a", @@ -78513,6 +149670,50 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009494", "pred" : "http://purl.obolibrary.org/obo/RO_0002254", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003099" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006235" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009550" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009501", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009501", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004066" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009501", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009503", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009503", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009505", "pred" : "is_a", @@ -78529,6 +149730,82 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009505", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002539" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009521", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009521", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009521", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009526", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009526", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009526", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005868" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009548", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001281" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009548", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009548", + "pred" : "http://purl.obolibrary.org/obo/RO_0002226", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009549", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001281" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009549", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009549", + "pred" : "http://purl.obolibrary.org/obo/RO_0002226", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009550", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000925" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009550", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006235" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009566", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018257" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009566", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002100" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002100" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009569", "pred" : "is_a", @@ -78693,6 +149970,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009618", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005256" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009621", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002329" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009621", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002415" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009644", "pred" : "is_a", @@ -78749,6 +150034,98 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009662", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002028" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009664", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009664", + "pred" : "http://purl.obolibrary.org/obo/RO_0001025", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001179" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012463" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000163" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "pred" : "http://purl.obolibrary.org/obo/RO_0002219", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009846" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000163" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012465" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009669" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002365" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010375" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003923" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002365" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010376" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003924" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009712", "pred" : "is_a", @@ -78817,6 +150194,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009751", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000948" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009752", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009752", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009758", "pred" : "is_a", @@ -78869,6 +150254,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009842", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0002422" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009521" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000163" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009854", "pred" : "is_a", @@ -78997,6 +150406,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009955", "pred" : "http://purl.obolibrary.org/obo/RO_0002385", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001785" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010371" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013697" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034969" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007329" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010000", "pred" : "is_a", @@ -79049,6 +150474,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010042", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004362" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010045", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010045", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007238" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010046", "pred" : "is_a", @@ -79081,6 +150514,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010077", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003914" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034932" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005604" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010083", "pred" : "is_a", @@ -79161,6 +150618,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010136", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010152", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010152", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004790" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010161", "pred" : "is_a", @@ -79173,6 +150638,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010161", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001981" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010162", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011676" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010162", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010162", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010183", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010183", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010183", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010188", "pred" : "is_a", @@ -79197,10 +150686,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010192", "pred" : "http://purl.obolibrary.org/obo/RO_0002178", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000991" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010194", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005806" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010194", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010194", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010199", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000466" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010204", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010204", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010227", "pred" : "is_a", @@ -79257,6 +150766,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010252", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007098" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010259" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010258" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010256", "pred" : "is_a", @@ -79325,6 +150850,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010259", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010276", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010276", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010285", "pred" : "is_a", @@ -79509,6 +151042,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010333", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005728" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010258" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010253" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010338" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010336", "pred" : "is_a", @@ -79541,6 +151106,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010337", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010339" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010338", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010338", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010341" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010338", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010045" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010339", "pred" : "is_a", @@ -79689,6 +151266,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010371", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/CL_0002077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009708" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009709" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010377", "pred" : "is_a", @@ -79729,6 +151338,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010378", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004873" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001265" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001194" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001265" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003713" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010409", "pred" : "is_a", @@ -79793,6 +151438,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010523", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010527", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002558" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010527", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001474" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010528", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010527" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010528", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008193" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010707", "pred" : "is_a", @@ -79889,6 +151550,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010912", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004288" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010913", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010913", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003089" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010959", "pred" : "is_a", @@ -79909,6 +151578,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011004", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002539" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008895" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004362" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007844" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011095", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011095", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011095", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005866" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011108", "pred" : "is_a", @@ -79945,6 +151662,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011138", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003089" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011148", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000414" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011148", + "pred" : "http://purl.obolibrary.org/obo/RO_0001025", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000009" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011148", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003350" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011156", "pred" : "is_a", @@ -79985,6 +151714,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011164", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002217" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003278" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011185", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011185", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011185", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011189", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004780" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011189", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001207" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011198", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012367" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011198", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011201", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012367" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011201", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001168" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011215", "pred" : "is_a", @@ -80037,6 +151814,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011234", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/UBERON_0011824" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011241", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011241", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003112" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011241", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005945" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011249", "pred" : "is_a", @@ -80133,6 +151922,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011585", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011592", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011592", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003235" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011592", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004068" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011592", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005868" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011595", "pred" : "is_a", @@ -80165,6 +151970,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011596", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005867" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011597", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012360" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011597", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003277" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011642", "pred" : "is_a", @@ -80201,6 +152014,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011676", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0013701" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003463" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004247" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004451" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009568" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011695", "pred" : "is_a", @@ -80221,6 +152050,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011772", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004768" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011773", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011773", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011597" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011773", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011597" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011777", "pred" : "is_a", @@ -80381,6 +152222,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011865", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001777" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011878", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018261" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011878", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001096" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011878", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001134" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011892", "pred" : "is_a", @@ -80453,6 +152306,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011953", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011955", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001143" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011955", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011956", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001143" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011956", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011997", "pred" : "is_a", @@ -80469,6 +152338,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012054", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003082" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012071", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003457" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012071", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008907" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012071", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012072", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012072", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012072", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007375" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012075", "pred" : "is_a", @@ -80589,6 +152482,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012360", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001708" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012361", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012361", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012367", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018261" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012367", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012375", "pred" : "is_a", @@ -80625,6 +152534,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012418", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003476" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012423", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012423", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/GO_0005902" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012425", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012425", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012429", "pred" : "is_a", @@ -80665,6 +152590,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012430", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001773" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012465" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012464", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012464", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012465", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012465", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012465", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012466", "pred" : "is_a", @@ -80681,6 +152642,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012467", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0000608" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012469", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012469", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012475", "pred" : "is_a", @@ -80697,6 +152666,106 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012475", "pred" : "http://purl.obolibrary.org/obo/RO_0002576", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010708" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012477", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005434" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012477", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001137" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012477", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000974" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012478", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012478", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012480", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000344" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012480", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012481", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012482", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018257" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012482", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012483", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012483", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012485", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012485", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012486", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018261" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012486", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012488", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011201" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012488", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012489", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011198" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012489", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012490", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012490", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011198" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012490", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012504", "pred" : "is_a", @@ -80705,6 +152774,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012504", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1100000" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012651", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001199" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012651", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001199" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012651", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012650" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013126", "pred" : "is_a", @@ -80745,6 +152842,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0013140", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004581" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013158", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013158", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006235" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013212", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013212", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004760" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013232", "pred" : "is_a", @@ -80781,6 +152894,102 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0013479", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004702" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013501", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013501", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014783" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011094" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018142" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_2001457" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013504" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013504", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013504", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018142" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003601" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011094" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015007" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_2001457" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013506" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002413" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013506", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013506", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015007" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011094" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015008" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_2001457" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013508" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002347" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015008" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013514", "pred" : "is_a", @@ -80821,6 +153030,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0013525", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013636", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001902" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013636", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013636", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001902" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013685", "pred" : "is_a", @@ -80849,6 +153070,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0013694", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000955" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013695", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000397" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013695", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001986" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013697", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013697", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013700", "pred" : "is_a", @@ -80977,6 +153214,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0014399", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003909" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014400", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014399" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014400", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001281" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014402", "pred" : "is_a", @@ -81057,6 +153302,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0014636", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003038" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010371" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004066" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000076" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014703", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014703", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010371" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014703", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014704", "pred" : "is_a", @@ -81081,6 +153358,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0014716", "pred" : "http://purl.obolibrary.org/obo/RO_0002170", "obj" : "http://purl.obolibrary.org/obo/UBERON_0009911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014717", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011858" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014717", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000414" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014717", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/CL_0000319" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014719", "pred" : "is_a", @@ -81117,6 +153406,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0014777", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014783", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001630" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014783", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014783", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014793", "pred" : "is_a", @@ -81181,6 +153482,46 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0014907", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005805" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015007", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015007", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015007", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005181" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006073" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015060", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015060", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010363" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015060", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011156" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015128", "pred" : "is_a", @@ -81289,6 +153630,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0015228", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0001690" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015280", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007324" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015280", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015212" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015280", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000120", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007324" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015212" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015281", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000121", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015329", "pred" : "is_a", @@ -81305,6 +153670,70 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0015410", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004535" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015480", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015480", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005436" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015480" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015480" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015485", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1100000" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015485", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015485", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015716", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001278" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015716", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015716", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015757", "pred" : "is_a", @@ -81317,6 +153746,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0015783", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015796", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015796", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015796", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015808", "pred" : "is_a", @@ -81337,6 +153778,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0015833", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015834", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001238" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015834", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008342" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016405", "pred" : "is_a", @@ -81357,6 +153806,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0016458", "pred" : "http://purl.obolibrary.org/obo/RO_0002570", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016478", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016478", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016478", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016490", "pred" : "is_a", @@ -81377,6 +153838,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0016509", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002080" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016512", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016512", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016513", "pred" : "is_a", @@ -81433,6 +153902,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0016550", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002240" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016552", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016552", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000065" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016553", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016553", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004785" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016566", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0036215" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016570", "pred" : "is_a", @@ -81445,6 +153934,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0016570", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002315" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016879", "pred" : "is_a", @@ -81473,6 +153978,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0016880", "pred" : "http://purl.obolibrary.org/obo/RO_0002496", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000111" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016885", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016885", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016886", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002385" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016886", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016887", "pred" : "is_a", @@ -81509,6 +154030,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0017672", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005172" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018111", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011198" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018111", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004220" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004231" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0016886" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0018135", "pred" : "is_a", @@ -81517,6 +154062,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0018135", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0002462" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018142", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018142", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018142", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006076" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0018150", "pred" : "is_a", @@ -81525,6 +154082,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0018150", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001835" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018151", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001458" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018151", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1000021" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018151", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001834" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018234", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018234", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0018239", "pred" : "is_a", @@ -81569,6 +154146,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0018260", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002385" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018261", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006660" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018261", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018261", + "pred" : "http://purl.obolibrary.org/obo/RO_0002216", + "obj" : "http://purl.obolibrary.org/obo/GO_0030432" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018415", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018415", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013685" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018415", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001679" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018543", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018543", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0018544", "pred" : "is_a", @@ -81601,6 +154210,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0018674", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000948" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001137" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018707", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000489" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018707", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009856" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018707", + "pred" : "http://purl.obolibrary.org/obo/RO_0000086", + "obj" : "http://purl.obolibrary.org/obo/PATO_0002468" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018707", + "pred" : "http://purl.obolibrary.org/obo/RO_0001015", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000463" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0019042", "pred" : "is_a", @@ -81625,6 +154266,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0019189", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005396" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000414" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005181" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0036225" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002048" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0019204", "pred" : "is_a", @@ -81697,6 +154358,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0022288", "pred" : "http://purl.obolibrary.org/obo/RO_0002007", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010230" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0022292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001980" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0022292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0022292", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0022293", "pred" : "is_a", @@ -81965,6 +154638,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0034929", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034932", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034932", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002294" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0034933", "pred" : "is_a", @@ -81977,6 +154658,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0034944", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034873" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034946", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034946", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0034947", "pred" : "is_a", @@ -82009,6 +154706,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0035037", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0011595" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035039", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035039", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0035050", "pred" : "is_a", @@ -82065,6 +154770,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0035546", "pred" : "http://purl.obolibrary.org/obo/RO_0002179", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001768" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035548", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035548", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0035549", "pred" : "is_a", @@ -82169,6 +154882,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0035804", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000930" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035805", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012489" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035805", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0035809", "pred" : "is_a", @@ -82317,6 +155038,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0036186", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0011824" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036214", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410024" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036214", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036214", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0036215", "pred" : "is_a", @@ -82437,6 +155170,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0036294", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001833" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036301", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002201" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036301", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006876" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036301", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0036302", "pred" : "is_a", @@ -82449,6 +155194,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0036303", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036343", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003697" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036343", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036343", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0036351", "pred" : "is_a", @@ -82465,6 +155222,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0036352", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001533" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036362", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036362", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036362", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0036422", "pred" : "is_a", @@ -82497,6 +155266,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0036925", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010230" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000060" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001697" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0037094", "pred" : "is_a", @@ -82525,6 +155310,46 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0037144", "pred" : "http://purl.obolibrary.org/obo/RO_0002371", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004292" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015482" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039228", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039228", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039228", + "pred" : "http://purl.obolibrary.org/obo/RO_0002376", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001215" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039261", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039261", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039261", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001194" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0039856", "pred" : "is_a", @@ -82553,6 +155378,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_1000021", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_1000024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_1000024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_1000024", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_1100000", "pred" : "is_a", @@ -82561,6 +155398,10 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_1100000", "pred" : "http://purl.obolibrary.org/obo/RO_0002176", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_2001073", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_2001457", "pred" : "is_a", @@ -82605,6 +155446,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_3000977", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002100" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_3000982", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_3000961" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_3000982", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_3010200", "pred" : "is_a", @@ -82669,6 +155518,154 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_8000009", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002354" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400021", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400023", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400023", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012375" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400023", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410001", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001979" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410001", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410004", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001980" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410004", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001979" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410008", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410009", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001980" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410009", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410015", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001980" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410015", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1100000" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410024", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410043", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410043", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410048", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001979" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410048", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001245" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410056", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001982" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410056", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410057", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001982" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410057", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410068", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001982" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410068", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011148" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0036225" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000065" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_8410081", "pred" : "is_a", @@ -82757,6 +155754,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_8600006", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_8600004" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8600012", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014717" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8600012", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011148" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_8600017", "pred" : "is_a", @@ -82849,6 +155854,10 @@ "sub" : "http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into", "pred" : "subPropertyOf", "obj" : "http://purl.obolibrary.org/obo/RO_0002170" + }, { + "sub" : "http://purl.obolibrary.org/obo/uberon/core#layer_part_of", + "pred" : "subPropertyOf", + "obj" : "http://purl.obolibrary.org/obo/BFO_0000050" }, { "sub" : "http://purl.obolibrary.org/obo/uberon/core#posteriorly_connected_to", "pred" : "subPropertyOf", @@ -83096,6 +156105,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000115" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000083", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000084", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000542" ], @@ -83245,6 +156261,23 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030072" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000168", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000151" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030073" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000169", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030073" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000170", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000151" ], @@ -83252,6 +156285,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0070091" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000171", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002067" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000172", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000151" ], @@ -83259,6 +156299,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0070253" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000173", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000174", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000151" ], @@ -83395,6 +156442,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003126" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000319", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000151" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070254" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000329", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], @@ -83430,6 +156484,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001134" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000358", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004590" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000359", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], @@ -83465,6 +156526,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002100", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001017" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000412", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053", + "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001377" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000413", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], @@ -83893,6 +156961,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0035935" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000666", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053", + "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002064" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000670", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000039" ], @@ -85017,6 +158092,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0043129" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002064", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000622" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001263" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002067", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], @@ -85045,6 +158127,26 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000222" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002079", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000083" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001064" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015106" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002080", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000083" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001263" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002087", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000738" ], @@ -85052,6 +158154,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/CL_4030045", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030141" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002088", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000710" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043134" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002092", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0001035" ], @@ -85108,6 +158217,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030224" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002195", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002202", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], @@ -85146,6 +158262,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053", "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002505" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002243", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001607" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002246", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000037" ], @@ -85167,6 +158290,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002253", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002563" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002254", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002563" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002262", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], @@ -85181,6 +158318,37 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002265", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002266", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002267", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002275", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000696" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002308", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], @@ -85336,6 +158504,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005742" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002504", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002521", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000136" ], @@ -85343,6 +158518,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002190" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002538", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000488" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004823" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002539", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000359" ], @@ -85399,6 +158581,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002012" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002563", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002570", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000134" ], @@ -85406,6 +158595,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001013" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002571", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000134" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002572", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000134" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002412" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002574", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002575", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000669" ], @@ -85511,6 +158721,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002658", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002659", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], @@ -85525,6 +158742,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002081" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002680", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000696" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0005000", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000099" ], @@ -85572,6 +158796,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002062" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0008024", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000163" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0008028", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000540" ], @@ -85603,6 +158834,114 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005388" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009006", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009018", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000542" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011189" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009021", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011189" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009022", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001238" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009024", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009025", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009038", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000235" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009040", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007177" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009042", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009044", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000542" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001238" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009048", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000235" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009051", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000084" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009052", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009053", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011189" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009063", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009089", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000669" ], @@ -85610,6 +158949,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009094", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001639" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009097", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0008002" ], @@ -85617,6 +158963,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002491", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000068" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009100", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001279" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0010001", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], @@ -85743,6 +159096,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002067" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0011108", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0011115", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], @@ -85806,6 +159166,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007196" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0019020", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000488" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004822" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0019021", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000398" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001279" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0019022", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000398" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006841" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000222", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000165" ], @@ -85834,6 +159215,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000275", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002504" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000276", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000275" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000279", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002504" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000280", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002504" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000285", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000280" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000286", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000303", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], @@ -85911,6 +159334,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002094" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000398", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001281" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000409", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000187" ], @@ -85946,6 +159376,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001979" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000415", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000428", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000723" ], @@ -86002,6 +159439,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002094" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000488", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000069" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000490", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000077" ], @@ -86030,6 +159477,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002401" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001433", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001516", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001242" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001567", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002139" ], @@ -86044,6 +159505,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002012" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001572", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001576", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000076" ], @@ -86051,6 +159519,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002424" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001588", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001589", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001592", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001595", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001598", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001599", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001603", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000235" ], @@ -86177,6 +159687,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002100", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002298" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000051", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000053", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000055", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000451" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000063", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], @@ -86212,6 +159743,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002407" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000069", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000070", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], @@ -86233,6 +159771,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000095" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000074", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000738" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000080", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002570" ], @@ -86310,6 +159855,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004802" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033005", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000313" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410043" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033008", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002543" ], @@ -86331,6 +159883,30 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000114" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033020", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000319" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005203" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033022", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000319" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410043" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033037", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000319" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007196" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410077" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033054", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], @@ -86338,6 +159914,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002049" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033061", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006841" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_4040004", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002570" ], @@ -86387,6 +159970,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18154" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0000272", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18154" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0000278", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007049" ], @@ -86513,6 +160103,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000970" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001655", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004122" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001674", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005634" ], @@ -86527,6 +160124,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0044207" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001678", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0019725" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001704", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], @@ -86785,6 +160389,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000115" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001889", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001935", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], @@ -87142,6 +160753,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002608", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000782" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0002384", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006955" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0002396", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -88180,6 +161798,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003381" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003222", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004126" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003225", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005064" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003227", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005066" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003228", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -88327,6 +161966,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", "fillerId" : "http://purl.obolibrary.org/obo/CL_2000022" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003309", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000169" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003310", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000171" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003311", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000173" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003312", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002275" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003313", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -88348,6 +162015,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004291" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003322", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000171" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003323", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000169" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003324", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000173" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003325", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048468" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002275" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003341", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007018" ], @@ -88512,6 +162207,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060350" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005275", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32952" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005319", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005342", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005355", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005583", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005581" ], @@ -88589,6 +162312,55 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18154" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005977", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005978", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005979", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005978" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005980", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005981", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005980" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006006", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006007", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006024", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -88596,6 +162368,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18085" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006027", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18085" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006082", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006094", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006109", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -88603,6 +162396,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005975" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006111", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006094" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006139", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], @@ -88617,6 +162417,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006308", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006309", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006308" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030262" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006325", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -88624,6 +162438,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0000785" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006401", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33697" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006412", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -88662,6 +162483,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006415" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006516", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17089" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006518", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], @@ -88683,6 +162511,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006694", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35341" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006699", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006706", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35341" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006811", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -88711,6 +162560,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006873", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0019725" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24867" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006886", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -88905,6 +162761,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002344", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005773" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007039", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030163" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005773" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007040", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -89097,6 +162960,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001041" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007442", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007492", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -89104,6 +162974,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000925" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007494", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007498", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -89177,6 +163054,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008202", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35341" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008206", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36235" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008284", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -89191,6 +163082,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0008283" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008320", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008347", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], @@ -89240,6 +163141,23 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008645", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009057", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33694" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009059", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -89261,6 +163179,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17089" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009250", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_37163" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009251", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_37163" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009306", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0046903" ], @@ -89282,6 +163214,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32952" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009310", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32952" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009416", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], @@ -89334,6 +163273,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009746", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009749", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009786", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -89397,6 +163350,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0008152" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009894", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009895", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009896", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009913", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -89620,6 +163594,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0022402" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010565", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0042180" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010566", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0042181" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010567", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0042182" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010594", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -89886,6 +163881,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0048243" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010710", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030574" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010711", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030574" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010712", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -90040,6 +164049,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0010818" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010827", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1904659" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010828", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1904659" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010829", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1904659" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010830", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -90075,6 +164105,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010893", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006694" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010894", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006694" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010906", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006006" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010907", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006006" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010927", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -90124,6 +164182,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0022402" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010962", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009250" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010968", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -90544,6 +164609,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015075", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24867" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015106", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17544" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015125", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_3098" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015144", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015149", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015159", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18154" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015671", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -90551,6 +164658,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_15379" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015701", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17544" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015718", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35757" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015721", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_3098" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015774", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -90572,6 +164700,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32952" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015849", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015850", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -90600,6 +164735,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_61120" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015932", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_61120" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016042", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016043", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009987" ], @@ -90628,6 +164777,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016052", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016053", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016054", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016057", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042391" ], @@ -90722,6 +164892,9 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33853" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019098", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007610", "http://purl.obolibrary.org/obo/GO_0048609" ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019216", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -90729,6 +164902,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006629" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019218", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008202" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019219", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -90750,6 +164930,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000540" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019318", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019319", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019320", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019336", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33853" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019538", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], @@ -90757,6 +164965,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019614", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33566" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019725", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042592" ], @@ -90764,6 +164979,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000000" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019752", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0021501", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], @@ -91267,6 +165489,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_1990904" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0022857", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0022884", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33694" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0022898", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0022857" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0023019", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007165" ], @@ -91361,6 +165604,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_25905" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030073", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0046903" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000009054" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030097", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], @@ -91403,6 +165653,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007155" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030163", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030182", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -91445,6 +165702,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16336" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030214", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16336" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030217", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -91585,6 +165849,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000192" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030573", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030574", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005581" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030595", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006935" ], @@ -91746,6 +166024,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005886" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031016", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031017", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031018", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000016" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031022", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007097" ], @@ -91935,6 +166234,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0044249" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031329", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044248" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031330", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044248" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031331", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044248" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031333", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -92081,6 +166401,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", "fillerId" : "http://purl.obolibrary.org/obo/GO_0043226" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031987", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0040011" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007626" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032024", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030073" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032057", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -92108,6 +166442,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032059" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032069", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004518" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032070", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004536" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032074", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004518" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032075", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004518" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032076", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004536" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032077", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004536" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032101", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -92234,6 +166610,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0002062" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032364", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0055082" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_15379" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032365", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -92307,6 +166690,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0046907" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032409", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005215" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032410", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005215" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032411", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005215" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032412", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015075" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032413", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015075" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032414", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015075" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032418", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0051179" ], @@ -92356,6 +166781,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33697" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032782", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0046903" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032787", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35757" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032790", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022411" ], @@ -92370,6 +166809,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0120025" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032868", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042221" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000009054" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032869", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000009054" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032871", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -92419,6 +166872,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007017" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032890", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015849" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032891", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015849" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032892", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015849" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032943", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], @@ -92629,6 +167103,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0009308" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033241", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009310" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033242", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009310" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033243", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009310" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033278", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], @@ -92667,6 +167162,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030141" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033500", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048878" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033604", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -92785,6 +167287,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0043603" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034251", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043605" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034252", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043605" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034253", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043605" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034329", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -92893,6 +167416,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_61120" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034655", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_61120" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034762", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -93103,6 +167633,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005576" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035622", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003704" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035628", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001152" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035645", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002504" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035701", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], @@ -93138,6 +167689,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000115" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035773", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030073" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0071333" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035774", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0035773" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035779", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -93152,6 +167717,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000025" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035844", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035855", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -93320,6 +167892,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000094" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0036333", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048872" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0012003", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000182" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0036334", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048872" ], @@ -93334,6 +167913,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000451" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0036342", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0036484", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], @@ -93543,6 +168129,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_6495" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042159", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_6495" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042176", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030163" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042177", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030163" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042180", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042181", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042182", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17087" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042221", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], @@ -93571,6 +168199,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_72587" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042422", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_72587" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042423", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -93578,6 +168213,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33567" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042424", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33567" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042427", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -93592,6 +168234,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_350546" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042429", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_350546" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042430", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], @@ -93606,6 +168255,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24828" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042436", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24828" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042461", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], @@ -93648,6 +168304,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002299", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000540" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042589", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016020" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0042588" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042593", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048878" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042670", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -93676,6 +168346,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32988" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042887", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32988" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042953", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -93836,6 +168513,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000586" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043085", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003824" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043086", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003824" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043133", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006939" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043134", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043133" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043143", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -93850,6 +168555,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33694" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043171", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_60466" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043227", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0043226" ], @@ -93983,6 +168695,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_25905" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043436", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35406" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043467", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006091" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043470", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043501", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0043500" ], @@ -94088,6 +168821,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32988" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043605", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32988" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043931", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0001503" ], @@ -94109,6 +168849,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032991" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044042", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_37163" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044057", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94130,6 +168877,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0050886" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044062", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007588" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044065", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94172,6 +168926,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044092", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003674" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044093", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003674" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044258", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044342", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0012003", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000169" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044346", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], @@ -94690,6 +169472,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0010001" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045719", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005978" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045721", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006094" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045722", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006094" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045724", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94697,6 +169500,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060271" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045725", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005978" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045727", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94704,6 +169514,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006412" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045732", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030163" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045759", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94802,6 +169619,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006897" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045818", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005980" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045819", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005980" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045822", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94998,6 +169829,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006139" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045939", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008202" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045940", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008202" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045947", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -95075,6 +169920,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33853" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046394", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046395", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046530", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -95201,6 +170060,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0046667" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046676", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030073" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046716", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0019725" ], @@ -95278,6 +170144,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005622" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046942", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046943", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0047496", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -95612,6 +170492,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0008150" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048520", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007610" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048521", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007610" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048522", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -95626,6 +170520,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0009987" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048536", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048539", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -96119,6 +171020,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000034" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048878", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042592" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048880", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -96350,6 +171258,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0008150" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050790", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003824" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050793", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -96364,6 +171279,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0009987" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050795", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007610" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050796", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030073" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050801", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048878" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24867" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050804", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -96399,6 +171335,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0045202" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050810", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006694" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050832", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006952" ], @@ -96546,6 +171489,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0019233" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050994", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016042" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050995", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016042" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050996", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016042" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051017", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -96560,6 +171524,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051033", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33697" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051035", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051046", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -96906,6 +171884,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", "fillerId" : "http://purl.obolibrary.org/obo/GO_0140013" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051336", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016787" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051345", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016787" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051346", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016787" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051402", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], @@ -96913,6 +171912,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000540" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051410", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0098754" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_51143" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051445", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -97433,6 +172439,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000031" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0055082", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0019725" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0055085", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -97440,6 +172453,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0055088", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048878" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0055094", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], @@ -97494,6 +172514,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001007" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060021", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007375" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060037", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -97776,6 +172803,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0051641" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060343", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000440" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060344", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010183" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060345", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001265" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060347", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002511" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060348", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048513" ], @@ -97986,6 +173041,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060425" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060450", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060451", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043133" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060452", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -98290,6 +173359,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005153" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060574", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0021700" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002299", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002563" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060575", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002563" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060576", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002563" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060577", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], @@ -98646,6 +173736,41 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060978" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061008", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002423" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061009", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002394" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061010", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061011", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001175" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061017", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_1000488" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061024", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -98877,6 +174002,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030324" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061113", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061114", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0061138" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0061113" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061117", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -98884,6 +174023,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060419" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061130", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003922" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061140", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -98919,6 +174065,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002202" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061153", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005203" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061154", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], @@ -98940,6 +174093,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002012" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061178", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0035773" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061179", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0035773" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061181", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -99066,6 +174233,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0061343" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061383", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000440" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061384", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002511" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061385", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048144" ], @@ -99087,6 +174268,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000351" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061453", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002088" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061458", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -99101,6 +174289,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005764" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061469", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044342" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061484", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048872" ], @@ -99136,6 +174331,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002590", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005929" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061525", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061548", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -99234,6 +174436,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032432" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061580", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0011108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061581", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], @@ -99241,6 +174450,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000575" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061582", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002563" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061626", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], @@ -99321,6 +174537,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007842" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0062012", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044281" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0062013", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044281" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0062014", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044281" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0062033", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -99376,6 +174613,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032993" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0065009", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003674" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0065010", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0043227" ], @@ -99516,6 +174760,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64628" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070254", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0046903" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000912" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070255", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070254" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070256", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070254" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070257", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070254" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070285", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], @@ -99551,6 +174823,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0070341" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070365", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000182" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070366", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070365" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070367", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070365" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070368", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070365" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070382", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030133" ], @@ -99614,6 +174914,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005604" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070857", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006699" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070858", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006699" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070859", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006699" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070873", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005977" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070874", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005977" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070875", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005977" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070925", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -99656,6 +174998,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071331", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071333", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071375", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], @@ -99932,6 +175288,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0070062" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072001", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048731" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001008" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072089", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], @@ -99967,6 +175330,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0010463" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072329", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35757" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072330", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35757" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072359", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -100008,6 +175385,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000057" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072560", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0021700" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002299", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000169" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072575", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050673" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0072576" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072576", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072577", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], @@ -100406,6 +175804,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006886" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0090325", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0031987" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0090326", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050789" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0031987" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0090327", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0031987" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0090425", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000622" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0090435", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -100489,6 +175915,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000100" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097050", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000169" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097060", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0098590" ], @@ -100524,6 +175957,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005765" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097272", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048878" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28938" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097275", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0055082" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28938" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097284", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000182" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097355", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -100750,6 +176204,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005886" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0098801", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003014" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0098840", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0046907" ], @@ -101219,6 +176680,19 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002608", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099546", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007268" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099547", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101280,6 +176754,42 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0098794" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099574", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007268" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099575", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042176" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098793" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007268" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099576", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042176" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007268" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099577", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101490,6 +177000,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0009887" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0110112", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005319" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0110113", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005319" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0110114", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005319" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0110116", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101602,6 +177133,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0043005" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120158", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030574" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120178", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006694" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_26764" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120186", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101616,6 +177161,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0071168" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120188", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032782" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120189", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032782" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120190", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032782" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120222", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101693,6 +177259,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0042953" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140096", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0003824" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140097", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0003824" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140098", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0003824" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33697" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140103", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0003824" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17089" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140131", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101775,6 +177369,82 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006412" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140246", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140247", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098793" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140249", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140250", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140251", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098793" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140252", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140318", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140352", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -101832,6 +177502,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0043228" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140734", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007588" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28938" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140962", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048871" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0150031", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101971,6 +177655,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001042" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0170055", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1900015", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101992,6 +177683,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0002534" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1900076", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032869" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1900077", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032869" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1900078", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032869" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1900115", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009966" ], @@ -102132,6 +177844,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0042742" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901142", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000009054" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901143", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000009054" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901148", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0010467" ], @@ -102146,6 +177872,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50994" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901161", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50994" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901162", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -102356,6 +178089,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35352" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901565", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35352" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901566", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -102391,6 +178131,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33822" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901616", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33822" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901617", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -102398,6 +178145,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33822" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901618", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33822" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901623", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -102426,6 +178180,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_60466" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901654", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901655", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17087" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901692", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -102748,6 +178516,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030261" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902369", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006401" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902414", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -102776,6 +178551,55 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0035418" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902488", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/CL_1000488" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902489", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0005026" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902494", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032991" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003824" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902495", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032991" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0022857" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902510", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006309" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902511", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006309" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902512", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006309" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902513", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103259,6 +179083,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007076" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903412", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_3098" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903413", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_3098" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903429", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103287,6 +179125,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060170" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903510", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_37395" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903522", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103434,6 +179279,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_1903441" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903624", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006308" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903625", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006308" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903626", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006308" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903697", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103518,6 +179384,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0061337" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903825", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903828", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103602,6 +179478,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007585" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903943", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097284" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903944", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097284" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903945", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097284" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903950", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103707,6 +179604,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_1904019" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904054", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990705" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904055", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990705" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904056", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990705" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904057", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103805,6 +179723,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060612" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904192", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1902488" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904193", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1902488" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904194", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1902488" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904204", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103833,6 +179772,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000669" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904251", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008206" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904252", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008206" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904253", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008206" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904269", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0099738" ], @@ -103840,6 +179800,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0031252" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904304", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0014831" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904305", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0014831" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904306", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0014831" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904341", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990765" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904342", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990765" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904343", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990765" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904344", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103861,6 +179863,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_1990768" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904347", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990770" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904348", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990770" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904349", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990770" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904350", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007039" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904351", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007039" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904352", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007039" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904375", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103959,6 +180003,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0019228" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904484", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0012478" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904491", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -104029,6 +180080,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0048286" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904659", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904675", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -104050,6 +180111,30 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0048103" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904680", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_60466" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904691", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044342" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904692", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044342" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904693", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], @@ -104057,6 +180142,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001891" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904697", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990863" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904698", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990863" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904699", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990863" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904705", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -104323,6 +180429,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0042118" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905039", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905063", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -104393,6 +180509,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_1905139" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905146", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030163" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005764" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905147", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -104435,6 +180558,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0010324" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905165", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1905146" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905166", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1905146" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905167", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1905146" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905207", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -104533,6 +180677,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0014033" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905298", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0060576" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905299", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0060576" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905300", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0060576" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905304", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -105303,6 +181468,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339", "fillerId" : "http://purl.obolibrary.org/obo/GO_0000785" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990351", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032991" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005215" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990502", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0021700" ], @@ -105310,6 +181482,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002299", "fillerId" : "http://purl.obolibrary.org/obo/GO_0031045" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990705", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0012003", + "fillerId" : "http://purl.obolibrary.org/obo/CL_1000488" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990748", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0098754" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000000" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990765", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006939" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990768", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008015" ], @@ -105317,6 +181510,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004786" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990770", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006939" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990778", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -105331,6 +181531,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005773" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990863", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0012003", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000622" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990874", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], @@ -105373,6 +181580,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0002213" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000074", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003323" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000077", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003323" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000078", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003323" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000106", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -105555,6 +181783,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0008585" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000226", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003310" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000227", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003310" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000228", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003310" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000241", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -105646,6 +181895,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0051450" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000292", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030421" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000293", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030421" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000294", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030421" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000351", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -105954,6 +182224,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0097049" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000674", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000675", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000676", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097050" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000690", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -106108,6 +182399,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0035935" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2001012", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048762" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0072001" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2001014", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -106425,6 +182723,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000165" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000168", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0013522" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000170", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0034925" ], @@ -106442,6 +182747,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007585" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000174", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000463" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002353", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007588" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000179", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000463" ], @@ -106449,6 +182761,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002193" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002217" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001092" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001676" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000304", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], @@ -106463,6 +182785,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002491", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000108" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000317", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000320", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000326", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000328", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -106477,6 +182820,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000136" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000333", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001242" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000355", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -106519,6 +182869,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002219", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000389" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000397", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000409", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002365" ], @@ -106533,6 +182890,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002185" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002365" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000319" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000415", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -106682,6 +183046,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0022600" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_8450002" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097254" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001013", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002384" ], @@ -106710,6 +183081,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000154" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001074", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002553" ], @@ -106766,6 +183147,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000214" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001095", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0018142" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002481" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001096", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -106773,6 +183161,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000075" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010913" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001133", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002036" ], @@ -106804,6 +183199,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000926" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005617" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001145", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], @@ -106811,6 +183220,29 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000992" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002150", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002150", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009870" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001165" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0008858" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0008861" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001167", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -106818,6 +183250,51 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001168", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001169", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001170", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000062" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002294" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002394" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001176", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003703" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002150", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001177", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003703" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002150", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001115" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001178", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0022350" ], @@ -106845,6 +183322,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000992" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001193", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001194", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001199", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -106866,6 +183357,118 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001167" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001166" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001204", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001205", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001206", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001207", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001208", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001209", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011148" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001215", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005617" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001238", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000030" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001242", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001243", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000161" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001555" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001262", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009842" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001265", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000440" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001268", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007779" ], @@ -106880,6 +183483,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001278", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003909" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001366", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0022351" ], @@ -106991,6 +183622,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001769" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001769" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001612", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], @@ -107052,6 +183690,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001645" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002481" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001708", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010912" ], @@ -107059,6 +183704,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002576", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011595" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000475" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002551", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003277" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001710", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000475" ], @@ -107167,6 +183819,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000013" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001834", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001833" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001835", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001833" ], @@ -107195,6 +183854,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003126" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001902", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001915", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001986" ], @@ -107281,6 +183947,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002221", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000232" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001971", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], @@ -107316,6 +183989,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001978", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001980", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001981" ], @@ -107350,6 +184030,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000115" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001988", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000174" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002353", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030421" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002012", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], @@ -107367,6 +184054,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002031", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -107589,6 +184283,19 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000915" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011216" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015721" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002299", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003215" ], @@ -107638,6 +184345,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000916" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015008" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002481" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002349", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005983" ], @@ -107707,6 +184421,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000187" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001173" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002400", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], @@ -107758,6 +184479,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002425" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002481" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002481" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002419", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], @@ -107793,6 +184528,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002240" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002466", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002469", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -107821,6 +184563,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/GO_0071953" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002561", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002558" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001017" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002616", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000481" ], @@ -107883,6 +184632,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000965" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002252", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005805" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003104", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000479" ], @@ -107932,6 +184691,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000992" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003235", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003236", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -107959,6 +184725,26 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000925" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003259", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000490" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000925" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003260", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000490" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000925" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003269", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001134" ], @@ -107966,6 +184752,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000019" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010912" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002576", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003278", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010912" ], @@ -107980,6 +184773,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003126" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003281", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003282", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000948" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003283", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003284", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003294", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], @@ -108029,6 +184850,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001040" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003324", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -108036,6 +184864,55 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001710" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003329", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003330", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003331", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003332", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003334", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003335", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003336", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003338", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000045" ], @@ -108050,6 +184927,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001017" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003342", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003343", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -108057,6 +184941,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000166" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003346", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003350", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -108071,6 +184962,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001042" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003352", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003353", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003354", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003364", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -108169,6 +185081,41 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002402" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003393", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001008" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003394", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003395", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003396", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003397", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003406", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007844" ], @@ -108232,6 +185179,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002224" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003452", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001133" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002511" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003457", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], @@ -108267,6 +185221,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001004" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001834" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003471", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], @@ -108288,6 +185249,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001004" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003477", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001834" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003478", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], @@ -108302,6 +185270,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002224" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003481", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003489", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001915" ], @@ -108421,6 +185396,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002224" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003524", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001981" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003526", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001982" ], @@ -108435,6 +185417,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000955" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003534", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000014" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003536", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002173" ], @@ -108561,6 +185550,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002224" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003599", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002384" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003601", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007844" ], @@ -108666,6 +185662,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001004" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003665", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0014892" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002371", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001095" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003684", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -108683,6 +185686,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002570", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001896" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000982" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001092" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001093" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003697", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -108690,6 +185703,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000916" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003704", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002394" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003714", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000479" ], @@ -108875,6 +185895,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002323" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003898", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001134" ], @@ -108910,6 +185937,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004582" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003928", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], @@ -109021,6 +186055,40 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000924" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000467" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000990" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001008" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004123", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#layer_part_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002349" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004124", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004123" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002165" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0036194" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004126", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004124" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002082" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004142", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002099" ], @@ -109069,6 +186137,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001137" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004220", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004222", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], @@ -109090,6 +186172,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004231", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001353" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004233", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], @@ -109118,6 +186207,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001981" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004238", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004239", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004240", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004242", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], @@ -109232,6 +186342,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004708" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004451", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002412" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000096", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001095" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004455", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000468" ], @@ -109263,6 +186380,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000974" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004468", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001015" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002371", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001130" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004469", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001015" ], @@ -109347,6 +186471,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002188" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004518", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0014892" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002371", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002412" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004521", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], @@ -109361,6 +186492,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002204" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004525", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003452" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004526", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003452" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002084" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004535", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000467" ], @@ -109538,6 +186683,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002067" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004760", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004764", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002481" ], @@ -109587,6 +186739,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004781", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000030" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004782", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], @@ -109594,6 +186753,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004783", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004784", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -109615,6 +186781,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004790", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000414" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002097" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004792", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000016" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004793", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004794", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], @@ -109622,6 +186809,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004795", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004797", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], @@ -109657,6 +186851,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001558" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002394" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004821", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -109664,6 +186865,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002299" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004822", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003703" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004823", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003704" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004830", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001134" ], @@ -109678,6 +186893,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004832", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001134" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001353" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004833", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001134" ], @@ -109685,6 +186907,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001833" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004834", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005171" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004848", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001917" ], @@ -109713,6 +186942,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004535" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004854", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004857", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002384" ], @@ -109748,6 +186984,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000966" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004867", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002553" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001697" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004883", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -109810,6 +187053,30 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000992" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004913", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004914" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004915", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004913" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004916", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001353" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004921", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0013522" ], @@ -109824,6 +187091,76 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001042" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004926", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001152" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004932", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004934", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001161" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004936", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001165" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004937", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001166" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004938", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001173" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004939", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001174" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004940", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001175" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004941", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001176" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004942", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001177" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004952", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], @@ -109831,6 +187168,83 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002186" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004988", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001152" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004993", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004995", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001161" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004997", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001165" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004998", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001166" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004999", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001173" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005000", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001174" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005001", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001175" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005002", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001176" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005003", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001177" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005031", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001834" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005032", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -109838,6 +187252,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001835" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005033", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005039", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -109880,6 +187301,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002193" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005064", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004126" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002084" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005066", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004126" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002080" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005076", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], @@ -109960,6 +187395,37 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000915" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005203", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011148" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003126" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005221", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005222", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001115" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005233", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000924" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004068" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005234", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000924" ], @@ -110099,6 +187565,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003902" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0013685" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001677" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002570", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000377" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005460", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005487" ], @@ -110151,6 +187627,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001804" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005616", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005617", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005637", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001166" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005638", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -110200,6 +187697,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002168" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005685", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002296" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005688", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -110221,6 +187725,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004348" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003397" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001041" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003397" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005720", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004582" ], @@ -110270,6 +187788,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000061" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005845", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005844" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006071" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005865", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005856" ], @@ -110333,6 +187858,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000948" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000440" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002302" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005989", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002099" ], @@ -110357,6 +187889,41 @@ "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000122", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000033" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006068", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005434" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000915" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006071" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000075" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001130" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006207", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002099" ], @@ -110367,6 +187934,30 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005805" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001679" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006236", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000209" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006239", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000043" ], @@ -110374,6 +187965,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006670" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006264", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], @@ -110384,6 +187982,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002131", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001041" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006271", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0013685" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001697" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006279", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003914" ], @@ -110446,6 +188051,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001004" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006555", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000025" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001008" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006563", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002522" ], @@ -110467,6 +188079,30 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002080" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006570", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002511" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006571", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002511" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002084" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000931" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006595", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006598" ], @@ -110521,6 +188157,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000483" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006686", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001130" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006761", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], @@ -110538,6 +188181,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000150" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006828", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002511" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002081" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006833", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -110559,6 +188209,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000062" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006877", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006904", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005253" ], @@ -110709,6 +188366,41 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002100" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007147", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007148", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007158", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007159", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007177", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000030" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000317" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007188", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001136" ], @@ -110891,6 +188583,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000026" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002170", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007376", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -110943,6 +188645,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0000086", "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001987" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007521", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000192" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007522", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000737" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007530", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -110992,6 +188708,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001896" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007652", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007719", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], @@ -111033,6 +188756,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000916" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002415" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006071" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007823", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000475" ], @@ -111040,6 +188770,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002551", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010719" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007826", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002358" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007828", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], @@ -111102,6 +188839,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007844" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008193", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010528" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008196", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0014892" ], @@ -111137,6 +188881,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410081" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008342", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001213" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008346", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008397", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -111179,6 +188937,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004364" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001167" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000325" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001166" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008870", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], @@ -111221,6 +188993,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002168" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011148" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009015", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000014" ], @@ -111263,6 +189042,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007811" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005866" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002418" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009204", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004068" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009479", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000924" ], @@ -111277,6 +189077,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006211" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009482", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009483", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006235" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009494", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111284,6 +189098,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002539" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009501", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004066" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009503", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009505", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111291,6 +189126,61 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003126" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009521", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000490" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000925" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009526", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005868" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009548", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001281" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001115" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009549", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001281" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009550", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000925" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009566", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009568", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002100" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002100" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009570", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005478" ], @@ -111361,6 +189251,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001891" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009621", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002329" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002415" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009652", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005769" ], @@ -111396,6 +189293,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002028" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000163" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009712", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001081" ], @@ -111424,6 +189335,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000948" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009752", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009758", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000045" ], @@ -111454,6 +189372,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0000086", "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002422" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000163" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009854", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009856" ], @@ -111502,6 +189427,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002385", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001785" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007329" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010000", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ], @@ -111533,6 +189465,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004362" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010045", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007238" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010047", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], @@ -111540,6 +189479,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000165" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003703" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001175" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010083", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111575,6 +189521,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002149" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010152", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000912" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004790" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010161", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -111582,6 +189535,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001981" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010162", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011676" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010183", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000440" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010192", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004573" ], @@ -111589,6 +189556,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000991" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010204", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010243", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002365" ], @@ -111606,6 +189580,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002342" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010045" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002342" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010256", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111643,6 +189627,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002342" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010276", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001130" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010294", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001986" ], @@ -111713,6 +189704,26 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005631" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002342" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006904" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010336", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111733,6 +189744,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006904" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010338", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010045" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006904" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010339", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111807,6 +189828,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000924" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009708" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010377", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111827,6 +189862,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004873" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001265" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001265" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010499", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010498" ], @@ -111834,6 +189883,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000067" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010527", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002558" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001474" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010708", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010707" ], @@ -111883,6 +189939,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0008895" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002418" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011095", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005866" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011108", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002217" ], @@ -111890,6 +189960,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001421" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011148", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000414" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000009" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011164", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], @@ -111897,6 +189974,44 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001703" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011171", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000982" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003277" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003278" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011185", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011189", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000030" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011198", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011201", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011215", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005162" ], @@ -111949,6 +190064,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002551", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001708" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011597", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011642", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -111959,6 +190081,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000924" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002412" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009568" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011695", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004535" ], @@ -111973,6 +190102,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004768" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011773", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011597" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011777", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000125" ], @@ -112059,6 +190195,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001777" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011878", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011919", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003061" ], @@ -112073,6 +190216,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006924" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011955", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001143" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001115" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011956", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001143" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012054", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002553" ], @@ -112080,6 +190237,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003082" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012071", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007375" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012172", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], @@ -112136,6 +190300,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011595" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012367", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012375", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], @@ -112167,6 +190338,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#site_of", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030097" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012464", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000161" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012465", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006866" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012466", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -112188,6 +190380,76 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002576", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010708" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012478", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012480", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012481", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012482", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012483", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012485", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0012423" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012486", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012488", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012489", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012490", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012504", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005742" ], @@ -112195,6 +190457,23 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012651", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0012650" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013126", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], @@ -112216,6 +190495,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004581" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013158", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013212", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004760" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013232", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009842" ], @@ -112237,6 +190530,55 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013501", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0018142" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002418" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013504", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0018142" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005866" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002418" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013506", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005866" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015008" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002418" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013508", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015008" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005866" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013514", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -112251,6 +190593,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013636", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001213" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013685", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005744" ], @@ -112265,6 +190614,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000955" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013695", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001986" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013697", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013700", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001015" ], @@ -112348,6 +190711,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003909" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014400", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0014399" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001281" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014402", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ], @@ -112413,6 +190783,23 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003038" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004066" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014703", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000490" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000924" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014704", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -112430,6 +190817,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002170", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009911" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014717", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009842" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000414" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014719", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], @@ -112461,6 +190855,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006241" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014783", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001630" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014793", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001015" ], @@ -112498,6 +190899,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002049" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015007", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006072" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006073" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015129", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001013" ], @@ -112556,6 +190971,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000126", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000465" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015280", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007324" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000120", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015281", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007324" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000121", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015329", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005769" ], @@ -112563,6 +190992,37 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001004" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001193" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001115" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001193" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015485", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002394" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015716", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015783", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], @@ -112570,6 +191030,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002072" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015796", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001981" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015808", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -112584,6 +191051,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001041" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015834", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000030" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016405", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001982" ], @@ -112601,6 +191075,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002570", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016478", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003891" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016490", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001032" ], @@ -112615,6 +191096,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002080" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016512", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016513", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002553" ], @@ -112653,6 +191141,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002020" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016552", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000912" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000065" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016553", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000912" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004785" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016570", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0022303" ], @@ -112660,6 +191162,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002315" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000481" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003072" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016879", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006598" ], @@ -112674,6 +191183,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001016" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016885", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006866" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016886", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002385" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006866" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0017650", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005423" ], @@ -112688,6 +191211,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000916" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018111", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018135", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011824" ], @@ -112695,6 +191232,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0000086", "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002462" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018142", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006076" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018150", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000014" ], @@ -112702,6 +191246,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001835" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018151", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000014" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001834" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018234", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003891" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018239", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], @@ -112723,6 +191281,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002385" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018261", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001555" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018415", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004111" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001679" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018543", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018544", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001630" ], @@ -112744,6 +191323,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000948" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0034929" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0019042", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -112765,6 +191351,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005396" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000414" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0019204", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -112807,6 +191400,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010230" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0022292", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001980" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0022293", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000463" ], @@ -112913,6 +191513,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002530" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0034932", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002294" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0034933", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], @@ -112920,6 +191527,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001135" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0034945", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0034873" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002353", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007588" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0034946", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0034945" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001555" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0034947", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0034873" ], @@ -112948,6 +191569,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011595" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035039", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035118", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ], @@ -112983,6 +191611,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001768" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035548", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035549", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], @@ -113039,6 +191674,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035805", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035809", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002553" ], @@ -113108,6 +191750,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/GO_0071953" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036214", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036217", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006314" ], @@ -113192,6 +191844,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001833" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036301", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036303", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], @@ -113199,6 +191858,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001017" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036343", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036351", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -113213,6 +191879,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001533" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036362", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001007" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036422", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -113234,6 +191910,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010230" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001697" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0037094", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -113248,6 +191931,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000948" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001152" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0039228", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0039261", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0039856", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001145" ], @@ -113269,6 +191973,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001456" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_1000024", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_1100000", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], @@ -113304,6 +192015,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002100" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_3000982", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_3000961" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_3010200", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001981" ], @@ -113342,6 +192060,120 @@ "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000121", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000468" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8400021", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8400023", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0012375" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410001", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001979" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001213" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410004", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001980" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001213" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410008", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001979" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410009", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001980" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410015", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001980" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410024", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004921" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410043", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011148" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002185" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410048", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001979" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004921" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001245" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410056", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001982" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410057", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001982" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410068", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001982" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011148" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000065" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8450002", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000467" ], @@ -113384,6 +192216,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000991" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8600012", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009842" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011148" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8600024", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001979" ], @@ -113438,6 +192277,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0002250", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0002384", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0002443", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113466,6 +192309,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0005929", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2759" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006915", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113502,6 +192349,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007565", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_40674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007610", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008347", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113546,6 +192397,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0021535", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030073", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030097", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113558,6 +192413,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0035805", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036342", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0040007", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113678,10 +192537,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0099536", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099546", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0099547", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099574", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0099643", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113698,10 +192565,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0140243", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140246", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140250", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0150077", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990765", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990770", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2001222", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", diff --git a/clm-full.obo b/clm-full.obo index c27dde1..8d098a7 100644 --- a/clm-full.obo +++ b/clm-full.obo @@ -1,12 +1,13 @@ format-version: 1.2 -data-version: clm/releases/2024-07-26/clm-full.owl +data-version: clm/releases/2024-07-29/clm-full.owl idspace: dce http://purl.org/dc/elements/1.1/ idspace: dcterms http://purl.org/dc/terms/ +idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# ontology: clm/clm-full property_value: dcterms:description "None" xsd:string property_value: dcterms:license https://creativecommons.org/licenses/unspecified property_value: dcterms:title "Cell Markers Ontology" xsd:string -property_value: owl:versionInfo "2024-07-26" xsd:string +property_value: owl:versionInfo "2024-07-29" xsd:string [Term] id: CHEBI:24431 @@ -19,6 +20,17 @@ equivalent_to: PR:000000001 [Term] id: CL:0000000 name: cell +def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] +comment: A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26. {xref="https://doi.org/10.5281/zenodo.11165918"} +comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). +xref: CALOHA:TS-2035 +xref: FMA:68646 +xref: GO:0005623 +xref: KUPO:0000002 +xref: MESH:D002477 +xref: VHOG:0001533 +xref: WBbt:0004017 +xref: XAO:0003012 is_a: UBERON:0000061 ! anatomical structure disjoint_from: GO:0031012 ! extracellular matrix disjoint_from: GO:0032991 ! protein-containing complex @@ -26,10 +38,12 @@ disjoint_from: GO:0043226 ! organelle relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001407", gci_relation="RO:0000053"} ! has part nucleus relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001908", gci_relation="RO:0000053"} ! has part nucleus relationship: RO:0002160 NCBITaxon:131567 ! cellular organisms +relationship: RO:0015004 CL:4037006 ! has characterizing marker set NS forest marker set of cell (Human Lung). [Term] id: CL:0000005 name: neural crest derived fibroblast +def: "Any fibroblast that is derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell @@ -38,6 +52,7 @@ relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell +def: "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception." [FBC:Autogenerated] is_a: CL:0000101 ! sensory neuron is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell @@ -47,21 +62,25 @@ intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involv [Term] id: CL:0000007 name: early embryonic cell (metazoa) +def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm] is_a: CL:0002321 ! embryonic cell (metazoa) [Term] id: CL:0000008 name: migratory cranial neural crest cell +def: "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007091] is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000011 name: migratory trunk neural crest cell +def: "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007095] is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000014 name: germ line stem cell +def: "A stem cell that is the precursor of gametes." [doi:10.1016/j.stem.2012.05.016] is_a: CL:0000034 ! stem cell is_a: CL:0000039 ! germ line cell intersection_of: CL:0000039 ! germ line cell @@ -70,6 +89,10 @@ intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division [Term] id: CL:0000021 name: female germ cell +def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446] +xref: MA:0000388 +xref: ncithesaurus:Egg +xref: VHOG:0001530 is_a: CL:0000586 ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0002215 GO:0048477 ! capable of oogenesis @@ -78,6 +101,7 @@ relationship: RO:0002215 GO:0048477 ! capable of oogenesis [Term] id: CL:0000022 name: female germ line stem cell +def: "A stem cell that is the precursor of female gametes." [doi:10.1016/j.stem.2012.05.016] is_a: CL:0000014 ! germ line stem cell is_a: CL:0000021 ! female germ cell intersection_of: CL:0000021 ! female germ cell @@ -86,6 +110,12 @@ intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division [Term] id: CL:0000023 name: oocyte +def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544] +xref: BTO:0000964 +xref: CALOHA:TS-0711 +xref: FMA:18644 +xref: MESH:D009865 +xref: WBbt:0006797 is_a: BFO:0000002 is_a: CL:0000021 ! female germ cell is_a: CL:0000255 ! eukaryotic cell @@ -95,6 +125,8 @@ relationship: RO:0002160 NCBITaxon:33208 ! Metazoa [Term] id: CL:0000024 name: oogonial cell +def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544] +xref: FMA:83673 is_a: BFO:0000002 is_a: CL:0000021 ! female germ cell intersection_of: CL:0000021 ! female germ cell @@ -105,6 +137,12 @@ relationship: RO:0002215 GO:0000278 ! capable of mitotic cell cycle [Term] id: CL:0000025 name: egg cell +def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544] +xref: BTO:0000369 +xref: BTO:0003801 +xref: CALOHA:TS-2191 +xref: FMA:67343 +xref: MESH:D010063 is_a: BFO:0000002 is_a: CL:0000675 ! female gamete relationship: RO:0000056 GO:0007143 ! participates in female meiotic nuclear division @@ -113,6 +151,7 @@ relationship: RO:0002202 CL:0000023 ! oocyte [Term] id: CL:0000027 name: smooth muscle cell neural crest derived +def: "A smooth muscle cell derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell @@ -121,6 +160,7 @@ relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000029 name: neural crest derived neuron +def: "Any neuron that develops from some migratory neural crest cell." [FBC:Autogenerated] is_a: BFO:0000002 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron @@ -131,6 +171,9 @@ relationship: RO:0002202 CL:0002676 ! neural crest derived neuroblast [Term] id: CL:0000031 name: neuroblast (sensu Vertebrata) +def: "A cell that will develop into a neuron often after a migration phase." [GOC:NV, http://en.wikipedia.org/wiki/Neuroblast] +xref: BTO:0000930 +xref: FMA:70563 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -138,16 +181,21 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: CL:0000034 name: stem cell +def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:D013234] +comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. +xref: CALOHA:TS-2086 +xref: FMA:63368 is_a: CL:0011115 ! precursor cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division relationship: RO:0002162 NCBITaxon:33208 ! Metazoa relationship: RO:0002215 GO:0017145 ! capable of stem cell division -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000035 name: single fate stem cell +def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm] +xref: FMA:70569 is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001400 ! bearer of @@ -157,6 +205,13 @@ relationship: RO:0000053 PATO:0001400 ! bearer of [Term] id: CL:0000037 name: hematopoietic stem cell +def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770] +comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. +xref: BTO:0000725 +xref: CALOHA:TS-0448 +xref: FMA:86475 +xref: MESH:D006412 +xref: VHOG:0001485 is_a: CL:0000723 ! somatic stem cell is_a: CL:0008001 ! hematopoietic precursor cell is_a: CL:0011026 ! progenitor cell @@ -189,11 +244,12 @@ relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part relationship: RO:0002202 CL:0000566 ! angioblastic mesenchymal cell relationship: RO:0002215 GO:0002244 ! capable of hematopoietic progenitor cell differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000038 name: erythroid progenitor cell +def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464] +xref: BTO:0004911 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell @@ -201,12 +257,18 @@ relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000039 name: germ line cell +def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] +comment: Originally this term had some plant germ line cell children. is_a: CL:0000000 ! cell relationship: RO:0002215 GO:0022414 ! capable of reproductive process [Term] id: CL:0000040 name: monoblast +def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740] +comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. +xref: CALOHA:TS-1195 +xref: FMA:83553 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell @@ -224,6 +286,8 @@ relationship: RO:0002202 CL:0002009 ! macrophage dendritic cell progenitor [Term] id: CL:0000048 name: multi fate stem cell +def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add] +xref: FMA:84789 is_a: CL:0000034 ! stem cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001402 ! bearer of @@ -233,15 +297,19 @@ relationship: RO:0000053 PATO:0001402 ! bearer of [Term] id: CL:0000049 name: common myeloid progenitor +def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461] +comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). +xref: BTO:0004730 is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell disjoint_from: CL:0000051 ! common lymphoid progenitor disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell +def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566] +comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell @@ -252,44 +320,65 @@ disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation relationship: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000051 name: common lymphoid progenitor +def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251] +comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000052 name: totipotent stem cell +def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm] +xref: FMA:84790 +xref: MESH:D039901 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000055 name: non-terminally differentiated cell +def: "A precursor cell with a limited number of potential fates." [SANBI:mhl] +comment: define using PATO mulit-potent or oligopotent? +xref: BTO:0000125 +xref: FMA:84782 is_a: CL:0011115 ! precursor cell [Term] id: CL:0000056 name: myoblast +def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:D032446, PMID:21849021] +xref: BTO:0000222 +xref: CALOHA:TS-0650 +xref: FMA:70335 +xref: VHOG:0001529 is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000057 name: fibroblast +def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:D005347] +comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. +xref: BTO:0000452 +xref: CALOHA:TS-0362 +xref: FMA:63877 +xref: NCIT:C12482 +xref: VHOG:0001482 is_a: BFO:0000002 is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000058 name: chondroblast +def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256] +xref: BTO:0003607 +xref: FMA:66783 is_a: BFO:0000002 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell @@ -299,6 +388,9 @@ relationship: RO:0003000 UBERON:0002418 ! produces cartilage tissue [Term] id: CL:0000064 name: ciliated cell +def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm] +xref: VHOG:0001532 +xref: XAO:0000031 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000051 GO:0005929 ! has part cilium @@ -307,14 +399,21 @@ relationship: BFO:0000051 GO:0005929 ! has part cilium [Term] id: CL:0000066 name: epithelial cell +def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:D004847] +xref: BTO:0000414 +xref: CALOHA:TS-2026 +xref: CARO:0000077 +xref: FMA:66768 +xref: WBbt:0003672 is_a: CL:0000000 ! cell disjoint_from: CL:0000738 ! leukocyte relationship: BFO:0000050 UBERON:0000483 ! part of epithelium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000067 name: ciliated epithelial cell +def: "An epithelial cell that has a cilia." [GOC:tfm] +xref: FMA:70605 is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell @@ -323,6 +422,7 @@ intersection_of: BFO:0000051 GO:0005929 ! has part cilium [Term] id: CL:0000068 name: duct epithelial cell +def: "An epithelial cell that is part of a duct." [https://orcid.org/0000-0001-5208-3432] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000058 ! part of duct @@ -336,35 +436,38 @@ is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000071 name: blood vessel endothelial cell +def: "An endothelial cell that lines the vasculature." [GOC:tfm] is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0004638 ! part of blood vessel endothelium relationship: RO:0002202 CL:0002546 ! embryonic blood vessel endothelial progenitor cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell +def: "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GO:0002065, https://orcid.org/0000-0001-5208-3432] is_a: CL:0000066 ! epithelial cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000076 name: squamous epithelial cell +xref: CALOHA:TS-1249 is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000077 name: mesothelial cell +def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [GOC:tfm, ISBN:0721662544] +xref: FMA:66773 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000080 name: circulating cell +def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid @@ -373,6 +476,9 @@ relationship: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid [Term] id: CL:0000081 name: blood cell +def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] +xref: FMA:62844 +xref: MESH:D001773 is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation @@ -381,24 +487,47 @@ relationship: RO:0002215 GO:0008015 ! capable of blood circulation [Term] id: CL:0000082 name: epithelial cell of lung +def: "An epithelial cell of the lung." [https://orcid.org/0000-0001-5208-3432] +xref: BTO:0004299 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000115 ! part of lung epithelium relationship: BFO:0000050 UBERON:0000115 ! part of lung epithelium +[Term] +id: CL:0000083 +name: epithelial cell of pancreas +def: "An epithelial cell of the pancreas." [GOC:tfm] +xref: BTO:0000028 +is_a: CL:0002076 ! endo-epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: CL:0000084 name: T cell +def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] +xref: BTO:0000782 +xref: CALOHA:TS-1001 +xref: FMA:62870 +xref: MESH:D013601 +xref: VHOG:0001479 is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: RO:0002215 GO:0002456 ! capable of T cell mediated immunity relationship: RO:0002202 CL:0000827 ! pro-T cell relationship: RO:0002215 GO:0002456 ! capable of T cell mediated immunity -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000092 name: osteoclast +def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158] +comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. +xref: BTO:0000968 +xref: CALOHA:TS-0721 +xref: FMA:66781 +xref: MESH:D010010 is_a: CL:0000518 ! phagocyte (sensu Vertebrata) is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0001035 ! bone cell @@ -425,6 +554,11 @@ relationship: RO:0002215 GO:0045453 ! capable of bone resorption [Term] id: CL:0000094 name: granulocyte +def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:D006098] +xref: BTO:0000539 +xref: BTO:0001026 +xref: CALOHA:TS-0422 +xref: FMA:62854 is_a: CL:0000081 ! blood cell is_a: CL:0000766 ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte @@ -445,7 +579,6 @@ relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part relationship: RO:0002104 PR:000001012 relationship: RO:0002104 PR:000001332 relationship: RO:0002104 PR:000001969 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000095 @@ -457,6 +590,9 @@ relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0000098 name: sensory epithelial cell +def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] +comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). +xref: BTO:0004301 is_a: CL:0000066 ! epithelial cell is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000066 ! epithelial cell @@ -465,27 +601,39 @@ intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involv [Term] id: CL:0000099 name: interneuron +def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:D007395] +xref: BTO:0003811 +xref: FMA:67313 +xref: WBbt:0005113 is_a: CL:0000540 ! neuron -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000100 name: motor neuron +def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:D009046, PMID:16875686] +xref: BTO:0000312 +xref: FMA:83617 +xref: WBbt:0005409 is_a: CL:0000527 ! efferent neuron -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000101 name: sensory neuron +def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544] +xref: BTO:0001037 +xref: FMA:84649 +xref: MESH:D011984 +xref: WBbt:0005759 is_a: CL:0000526 ! afferent neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000107 name: autonomic neuron +def: "A neuron whose cell body is within an autonomic ganglion." [GOC:tfm] +xref: FMA:80121 is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002410 ! autonomic nervous system @@ -494,19 +642,24 @@ relationship: RO:0002100 UBERON:0002410 ! autonomic nervous system [Term] id: CL:0000113 name: mononuclear phagocyte +def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149] +xref: BTO:0001433 is_a: CL:0000518 ! phagocyte (sensu Vertebrata) is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: RO:0000053 PATO:0001407 ! bearer of -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000115 name: endothelial cell +def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341] +comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. +xref: BTO:0001176 +xref: CALOHA:TS-0278 +xref: FMA:66772 is_a: BFO:0000002 is_a: CL:0000213 ! lining cell relationship: RO:0002202 CL:0000222 ! mesodermal cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000117 @@ -519,32 +672,49 @@ relationship: RO:0002202 CL:0000031 ! neuroblast (sensu Vertebrata) [Term] id: CL:0000125 name: glial cell +def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457] +comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 +xref: BTO:0002606 +xref: CALOHA:TS-0415 +xref: FMA:54536 is_a: CL:0000095 ! neuron associated cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000133 name: neurectodermal cell +def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X] is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000134 name: mesenchymal stem cell +def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544] +comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. +xref: BTO:0002625 +xref: BTO:0003298 +xref: FMA:70546 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000136 name: adipocyte +def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:D017667] +xref: BTO:0000443 +xref: CALOHA:TS-0012 +xref: FMA:63880 is_a: BFO:0000002 is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000138 name: chondrocyte +def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:D019902] +xref: BTO:0000249 +xref: CALOHA:TS-0138 +xref: FMA:66782 is_a: CL:0000153 ! glycosaminoglycan secreting cell is_a: CL:0000667 ! collagen secreting cell relationship: RO:0001025 UBERON:0002418 ! cartilage tissue @@ -553,6 +723,8 @@ relationship: RO:0002202 CL:0000058 ! chondroblast [Term] id: CL:0000145 name: professional antigen presenting cell +def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149] +comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II @@ -561,6 +733,8 @@ relationship: RO:0002215 GO:0002504 ! capable of antigen processing and presenta [Term] id: CL:0000147 name: pigment cell +def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm] +xref: VHOG:0001678 is_a: CL:0000325 ! stuff accumulating cell [Term] @@ -571,6 +745,9 @@ is_a: CL:0000147 ! pigment cell [Term] id: CL:0000150 name: glandular epithelial cell +def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [GOC:tfm] +xref: CALOHA:TS-2085 +xref: FMA:86494 is_a: CL:0000066 ! epithelial cell is_a: CL:0000151 ! secretory cell relationship: BFO:0000050 UBERON:0006799 ! part of glandular epithelium @@ -578,6 +755,9 @@ relationship: BFO:0000050 UBERON:0006799 ! part of glandular epithelium [Term] id: CL:0000151 name: secretory cell +def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] +xref: BTO:0003659 +xref: FMA:86916 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0032940 ! capable of secretion by cell @@ -586,6 +766,8 @@ relationship: RO:0002215 GO:0032940 ! capable of secretion by cell [Term] id: CL:0000152 name: exocrine cell +def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684] +xref: FMA:16014 is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002365 ! part of exocrine gland @@ -594,12 +776,14 @@ relationship: BFO:0000050 UBERON:0002365 ! part of exocrine gland [Term] id: CL:0000153 name: glycosaminoglycan secreting cell +def: "A cell that secretes glycosaminoglycans." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell [Term] id: CL:0000154 name: protein secreting cell +def: "Any secretory cell that is capable of some protein secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0009306 ! capable of protein secretion @@ -608,6 +792,7 @@ relationship: RO:0002215 GO:0009306 ! capable of protein secretion [Term] id: CL:0000157 name: surfactant secreting cell +def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [GOC:tfm, ISBN:0721662544] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0043129 ! capable of surfactant homeostasis @@ -616,11 +801,13 @@ relationship: RO:0002215 GO:0043129 ! capable of surfactant homeostasis [Term] id: CL:0000158 name: club cell +def: "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium." [DOI:10.1183/09031936.00146609, DOI:10.1378/chest.12-2762, GOC:tfm, PMID:28128362, PMID:29874100, PMID:7905712] +xref: BTO:0004811 +xref: FMA:14119 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0011026 ! progenitor cell relationship: RO:0002104 GO:0005902 ! microvillus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000159 @@ -630,67 +817,161 @@ is_a: CL:0000151 ! secretory cell [Term] id: CL:0000163 name: endocrine cell +def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:D055098] +xref: FMA:83809 is_a: CL:0000151 ! secretory cell is_a: CL:0000164 {gci_filler="UBERON:0000945", gci_relation="BFO:0000050"} ! enteroendocrine cell +is_a: CL:0000164 {gci_filler="UBERON:0000160", gci_relation="BFO:0000050"} ! enteroendocrine cell +is_a: CL:0000164 {gci_filler="UBERON:0001264", gci_relation="BFO:0000050"} ! enteroendocrine cell relationship: BFO:0000050 UBERON:0000949 ! part of endocrine system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000164 name: enteroendocrine cell +def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl] +xref: BTO:0003865 +xref: FMA:62930 +xref: MESH:D019858 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000165 name: neuroendocrine cell +def: "A neuron that is capable of some hormone secretion in response to neuronal signals." [MESH:D055099] +comment: The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. {xref="https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073", xref="PMID:5342440"} +xref: BTO:0002691 +xref: FMA:83810 is_a: CL:0000163 ! endocrine cell is_a: CL:0000527 ! efferent neuron is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0046879 ! capable of hormone secretion -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000167 name: peptide hormone secreting cell +def: "Any secretory cell that is capable of some peptide hormone secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030072 ! capable of peptide hormone secretion relationship: RO:0002215 GO:0030072 ! capable of peptide hormone secretion +[Term] +id: CL:0000168 +name: insulin secreting cell +def: "Any secretory cell that is capable of some insulin secretion." [FBC:Autogenerated] +xref: BTO:0000783 +is_a: CL:0000154 ! protein secreting cell +is_a: CL:0000167 ! peptide hormone secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: RO:0002215 GO:0030073 ! capable of insulin secretion +relationship: RO:0002215 GO:0030073 ! capable of insulin secretion + +[Term] +id: CL:0000169 +name: type B pancreatic cell +def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651] +comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. +xref: BTO:0000783 +xref: EV:0200009 +xref: FMA:70586 +xref: MA:0002419 +xref: ncithesaurus:Beta_Cell +is_a: CL:0000168 ! insulin secreting cell +is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans +intersection_of: RO:0002215 GO:0030073 ! capable of insulin secretion +relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans +relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas + [Term] id: CL:0000170 name: glucagon secreting cell +def: "A cell that secretes glucagon." [GOC:tfm] +xref: FMA:84045 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070091 ! capable of glucagon secretion relationship: RO:0002215 GO:0070091 ! capable of glucagon secretion +[Term] +id: CL:0000171 +name: pancreatic A cell +def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544] +xref: BTO:0000990 +xref: FMA:70585 +xref: MESH:D050416 +is_a: CL:0002067 ! type A enteroendocrine cell +is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0002067 ! type A enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans +relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas + [Term] id: CL:0000172 name: somatostatin secreting cell +def: "Any secretory cell that is capable of some somatostatin secretion." [FBC:Autogenerated] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070253 ! capable of somatostatin secretion relationship: RO:0002215 GO:0070253 ! capable of somatostatin secretion +[Term] +id: CL:0000173 +name: pancreatic D cell +def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm] +xref: BTO:0000803 +xref: FMA:70587 +is_a: CL:0000502 ! type D enteroendocrine cell +is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans +relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas + [Term] id: CL:0000174 name: steroid hormone secreting cell +def: "Any secretory cell that is capable of some steroid hormone secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035929 ! capable of steroid hormone secretion relationship: RO:0002215 GO:0035929 ! capable of steroid hormone secretion +[Term] +id: CL:0000182 +name: hepatocyte +def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:D022781, PMID:19717280] +comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. +xref: BTO:0000575 +xref: CALOHA:TS-0454 +xref: FMA:14515 +is_a: BFO:0000002 +is_a: CL:0000066 ! epithelial cell +is_a: CL:0000417 ! endopolyploid cell +relationship: BFO:0000050 UBERON:0002107 ! part of liver +relationship: RO:0002202 CL:0005026 ! hepatoblast +relationship: RO:0002215 GO:0006699 ! capable of bile acid biosynthetic process +relationship: RO:0002215 GO:0098754 ! capable of detoxification + [Term] id: CL:0000183 name: contractile cell +def: "A cell whose primary function is to shorten." [FB:ma] is_a: CL:0000000 ! cell [Term] id: CL:0000187 name: muscle cell +def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:D032342] +xref: BTO:0000888 +xref: BTO:0000902 +xref: CALOHA:TS-2032 +xref: FMA:67328 +xref: WBbt:0003675 is_a: BFO:0000002 is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell @@ -699,24 +980,31 @@ relationship: RO:0002202 CL:0000056 ! myoblast [Term] id: CL:0000188 name: cell of skeletal muscle +def: "A somatic cell located in skeletal muscle." [GOC:tfm] +xref: BTO:0004392 +xref: CALOHA:TS-2158 +xref: FMA:9727 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue relationship: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000192 name: smooth muscle cell +def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:D032389, PMID:9315361] +xref: BTO:0004576 +xref: CALOHA:TS-2159 +xref: FMA:14072 is_a: CL:0008000 ! non-striated muscle cell is_a: CL:0008007 ! visceral muscle cell relationship: RO:0002202 CL:0000514 ! smooth muscle myoblast -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000197 name: sensory receptor cell def: "A cell that is capable of detection of a stimulus involved in sensory perception." [] +xref: MESH:D011984 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001032 ! part of sensory system @@ -727,6 +1015,7 @@ relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved [Term] id: CL:0000206 name: chemoreceptor cell +def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:D002628] is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: RO:0002215 GO:0050907 ! capable of detection of chemical stimulus involved in sensory perception @@ -735,6 +1024,10 @@ relationship: RO:0002215 GO:0050907 ! capable of detection of chemical stimulus [Term] id: CL:0000210 name: photoreceptor cell +def: "A cell specialized to detect and transduce light." [MESH:D010786] +xref: BTO:0001060 +xref: CALOHA:TS-0868 +xref: FMA:86740 is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050962 ! capable of detection of light stimulus involved in sensory perception @@ -743,17 +1036,20 @@ relationship: RO:0002215 GO:0050962 ! capable of detection of light stimulus inv [Term] id: CL:0000211 name: electrically active cell +def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma] is_a: CL:0000000 ! cell [Term] id: CL:0000213 name: lining cell +def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb] is_a: CL:0000215 ! barrier cell [Term] id: CL:0000214 name: synovial cell def: "A cell located in the synovial joint." [] +xref: CALOHA:TS-0995 is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell relationship: BFO:0000050 UBERON:0002217 ! part of synovial joint @@ -761,11 +1057,13 @@ relationship: BFO:0000050 UBERON:0002217 ! part of synovial joint [Term] id: CL:0000215 name: barrier cell +def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb] is_a: CL:0000000 ! cell [Term] id: CL:0000219 name: motile cell +def: "A cell that moves by its own activities." [FB:ma] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0048870 ! capable of cell motility @@ -774,24 +1072,31 @@ relationship: RO:0002215 GO:0048870 ! capable of cell motility [Term] id: CL:0000221 name: ectodermal cell +def: "A cell of the outer of the three germ layers of the embryo." [MESH:D004475] +xref: FMA:72549 is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm [Term] id: CL:0000222 name: mesodermal cell +def: "A cell of the middle germ layer of the embryo." [MESH:D008648] +xref: FMA:72554 is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm [Term] id: CL:0000223 name: endodermal cell +def: "A cell of the inner of the three germ layers of the embryo." [MESH:D004707] +xref: FMA:72555 is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000925 ! part of endoderm [Term] id: CL:0000226 name: single nucleate cell +def: "A cell with a single nucleus." [FB:ma, GOC:tfm] is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001407 ! bearer of @@ -800,6 +1105,9 @@ relationship: RO:0000053 PATO:0001407 ! bearer of [Term] id: CL:0000228 name: multinucleate cell +def: "A cell with more than one nucleus." [FB:ma] +xref: AEO:0000203 +xref: WBbt:0008074 is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001908 ! bearer of @@ -808,6 +1116,10 @@ relationship: RO:0000053 PATO:0001908 ! bearer of [Term] id: CL:0000232 name: erythrocyte +def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:D004912] +xref: BTO:0000424 +xref: CALOHA:TS-0290 +xref: FMA:81100 is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 ! erythroid lineage cell @@ -821,11 +1133,14 @@ relationship: CL:4030045 GO:0005840 ! lacks_part ribosome relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part relationship: RO:0000053 PATO:0002039 ! bearer of relationship: RO:0002202 CL:0000558 ! reticulocyte -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000234 name: phagocyte +def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464] +xref: BTO:0001044 +xref: FMA:83806 +xref: MESH:D010586 is_a: CL:0000219 ! motile cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000473 ! defensive cell @@ -836,6 +1151,13 @@ relationship: RO:0002215 GO:0006909 ! capable of phagocytosis [Term] id: CL:0000235 name: macrophage +def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:16213494, PMID:1919437] +comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. +xref: BTO:0000801 +xref: CALOHA:TS-0587 +xref: FMA:63261 +xref: FMA:83585 +xref: MESH:D008264 is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000766 ! myeloid leukocyte @@ -845,11 +1167,12 @@ intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis intersection_of: RO:0002215 GO:0031268 ! capable of pseudopodium organization relationship: RO:0002202 CL:0000576 ! monocyte relationship: RO:0002215 GO:0031268 ! capable of pseudopodium organization -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000255 name: eukaryotic cell +def: "Any cell that only exists in Eukaryota." [FBC:Autogenerated] +xref: MESH:D005057 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002160 NCBITaxon:2759 ! Eukaryota @@ -858,6 +1181,7 @@ relationship: RO:0002160 NCBITaxon:2759 ! Eukaryota [Term] id: CL:0000257 name: Eumycetozoan cell +def: "Any cell that only exists in Eumycetozoa." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002160 NCBITaxon:142796 ! Eumycetozoa @@ -866,20 +1190,24 @@ relationship: RO:0002160 NCBITaxon:142796 ! Eumycetozoa [Term] id: CL:0000287 name: eye photoreceptor cell +def: "Any photoreceptor cell that is part of some eye." [FBC:Autogenerated] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000970 ! part of eye relationship: BFO:0000050 UBERON:0000970 ! part of eye -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000293 name: structural cell +def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr] is_a: CL:0000000 ! cell [Term] id: CL:0000300 name: gamete +def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544] +xref: CALOHA:TS-0395 +xref: FMA:18649 is_a: CL:0000413 ! haploid cell is_a: CL:0000586 ! germ cell intersection_of: CL:0000586 ! germ cell @@ -895,6 +1223,9 @@ is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000307 name: tracheal epithelial cell +def: "An epithelial cell found in the trachea." [GOC:tfm] +comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' +xref: FMA:74793 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea @@ -904,11 +1235,28 @@ relationship: RO:0002202 CL:0000377 ! tracheoblast [Term] id: CL:0000313 name: serous secreting cell +def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] +xref: BTO:0003687 +xref: FMA:62511 +is_a: CL:0000159 ! seromucus secreting cell + +[Term] +id: CL:0000319 +name: mucus secreting cell +def: "Any secretory cell that is capable of some mucus secretion." [FBC:Autogenerated] +xref: BTO:0003689 is_a: CL:0000159 ! seromucus secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: RO:0002215 GO:0070254 ! capable of mucus secretion +relationship: RO:0002215 GO:0070254 ! capable of mucus secretion [Term] id: CL:0000322 name: pulmonary alveolar epithelial cell +def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [GOC:tfm, PMID:20054144, PMID:29463737] +xref: BTO:0000395 +xref: CALOHA:TS-2168 +xref: FMA:62499 is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0010003 ! epithelial cell of alveolus of lung relationship: BFO:0000050 UBERON:0004821 ! part of pulmonary alveolus epithelium @@ -916,6 +1264,7 @@ relationship: BFO:0000050 UBERON:0004821 ! part of pulmonary alveolus epithelium [Term] id: CL:0000325 name: stuff accumulating cell +def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma] is_a: CL:0000000 ! cell [Term] @@ -926,6 +1275,7 @@ is_a: CL:0000499 ! stromal cell [Term] id: CL:0000329 name: oxygen accumulating cell +def: "Any cell that is capable of some oxygen transport." [FBC:Autogenerated] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0015671 ! capable of oxygen transport @@ -934,6 +1284,8 @@ relationship: RO:0002215 GO:0015671 ! capable of oxygen transport [Term] id: CL:0000333 name: migratory neural crest cell +def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [doi:10.1016/j.stem.2015.02.017] +xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0011012 ! neural crest cell is_a: CL:0011026 ! progenitor cell @@ -942,11 +1294,13 @@ relationship: RO:0002202 CL:0007004 ! premigratory neural crest cell [Term] id: CL:0000335 name: mesenchyme condensation cell +def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] is_a: CL:0008019 ! mesenchymal cell [Term] id: CL:0000347 name: scleral cell +def: "A cell of the sclera of the eye." [GOC:add] is_a: BFO:0000002 is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell @@ -957,6 +1311,7 @@ relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000348 name: choroidal cell of the eye +def: "A structural cell that is part of optic choroid." [GOC:add] is_a: BFO:0000002 is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell @@ -967,6 +1322,7 @@ relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000349 name: extraembryonic cell +def: "Any cell that is part of some extraembryonic structure." [FBC:Autogenerated] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure @@ -975,40 +1331,63 @@ relationship: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure [Term] id: CL:0000351 name: trophoblast cell +def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:D014327] +xref: FMA:83028 is_a: CL:0000349 ! extraembryonic cell relationship: BFO:0000050 UBERON:0000358 ! part of blastocyst [Term] id: CL:0000352 name: epiblast cell +def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256] is_a: CL:0000052 ! totipotent stem cell [Term] id: CL:0000353 name: blastoderm cell +def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:D001756] +xref: BTO:0001473 +xref: FMA:72551 is_a: CL:0000007 ! early embryonic cell (metazoa) [Term] id: CL:0000355 name: multi-potent skeletal muscle stem cell +def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570] +comment: Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. +xref: FMA:86767 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000188 ! cell of skeletal muscle intersection_of: CL:0000048 ! multi fate stem cell intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue +[Term] +id: CL:0000358 +name: sphincter associated smooth muscle cell +def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm] +is_a: CL:0000192 ! smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: BFO:0000050 UBERON:0004590 ! part of sphincter muscle +relationship: BFO:0000050 UBERON:0004590 ! part of sphincter muscle + [Term] id: CL:0000359 name: vascular associated smooth muscle cell +def: "A smooth muscle cell associated with the vasculature." [GOC:dsd, GOC:tfm] is_a: CL:0000192 ! smooth muscle cell is_a: CL:4033054 ! perivascular cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002049 ! part of vasculature relationship: BFO:0000050 UBERON:0002049 ! part of vasculature -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000362 name: epidermal cell +def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma] +xref: BTO:0001470 +xref: CALOHA:TS-0283 +xref: FMA:62411 +xref: MESH:D000078404 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0007376 ! part of outer epithelium @@ -1017,6 +1396,10 @@ relationship: BFO:0000050 UBERON:0007376 ! part of outer epithelium [Term] id: CL:0000365 name: animal zygote +def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208] +xref: BTO:0000854 +xref: EHDAA2:0004546 +xref: FMA:72395 is_a: CL:0000007 ! early embryonic cell (metazoa) is_a: CL:0000255 ! eukaryotic cell is_a: CL:0010017 ! zygote @@ -1032,11 +1415,13 @@ is_a: CL:0000069 ! branched duct epithelial cell [Term] id: CL:0000393 name: electrically responsive cell +def: "A cell whose function is determined by its response to an electric signal." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000397 name: ganglion interneuron +def: "Any interneuron that has its soma located in some ganglion." [FBC:Autogenerated] is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000045 ! ganglion @@ -1045,25 +1430,42 @@ relationship: RO:0002100 UBERON:0000045 ! ganglion [Term] id: CL:0000402 name: CNS interneuron +def: "An interneuron that has its cell body in a central nervous system." [doi:10.1016/B978-0-12-817424-1.00001-X] +comment: Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system. is_a: CL:0000099 ! interneuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0001017 ! central nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000404 name: electrically signaling cell +def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma] is_a: CL:0000211 ! electrically active cell +[Term] +id: CL:0000412 +name: polyploid cell +def: "A cell that contains more than two haploid sets of chromosomes." [FB:ma, https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy, PMID:32646579] +is_a: CL:0000000 ! cell +intersection_of: CL:0000000 ! cell +intersection_of: RO:0000053 PATO:0001377 ! bearer of +relationship: RO:0000053 PATO:0001377 ! bearer of + [Term] id: CL:0000413 name: haploid cell +def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001375 ! bearer of relationship: RO:0000053 PATO:0001375 ! bearer of +[Term] +id: CL:0000417 +name: endopolyploid cell +is_a: CL:0000412 ! polyploid cell + [Term] id: CL:0000447 name: carbohydrate secreting cell @@ -1072,6 +1474,11 @@ is_a: CL:0000151 ! secretory cell [Term] id: CL:0000451 name: dendritic cell +def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149] +xref: BTO:0002042 +xref: CALOHA:TS-0194 +xref: FMA:83036 +xref: MESH:D003713 is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000145 ! professional antigen presenting cell intersection_of: CL:0000738 ! leukocyte @@ -1095,7 +1502,6 @@ relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0045580 ! capable of regulation of T cell differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000457 @@ -1105,6 +1511,7 @@ is_a: CL:0000151 ! secretory cell [Term] id: CL:0000458 name: serotonin secreting cell +def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0001820 ! capable of serotonin secretion @@ -1113,6 +1520,7 @@ relationship: RO:0002215 GO:0001820 ! capable of serotonin secretion [Term] id: CL:0000459 name: noradrenergic cell +def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0048243 ! capable of norepinephrine secretion @@ -1121,11 +1529,13 @@ relationship: RO:0002215 GO:0048243 ! capable of norepinephrine secretion [Term] id: CL:0000473 name: defensive cell +def: "A cell whose primary function is to protect the organism." [JB:jb] is_a: CL:0000000 ! cell [Term] id: CL:0000488 name: visible light photoreceptor cell +def: "A photoreceptor cell that detects visible light." [GOC:tfm] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: RO:0002215 GO:0009584 ! capable of detection of visible light @@ -1134,14 +1544,56 @@ relationship: RO:0002215 GO:0009584 ! capable of detection of visible light [Term] id: CL:0000499 name: stromal cell +def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:D017154] +xref: BTO:0002064 +xref: FMA:83624 is_a: BFO:0000002 is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0000502 +name: type D enteroendocrine cell +def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:D019864] +xref: FMA:62935 +is_a: CL:0000164 ! enteroendocrine cell +is_a: CL:0000172 ! somatostatin secreting cell + +[Term] +id: CL:0000506 +name: enkephalin secreting cell +def: "An endorphine cell that secretes enkephalin." [GO:tfm] +is_a: CL:0000507 ! endorphin secreting cell + +[Term] +id: CL:0000507 +name: endorphin secreting cell +def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm] +is_a: CL:0000167 ! peptide hormone secreting cell + +[Term] +id: CL:0000508 +name: type G enteroendocrine cell +def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:D019863] +xref: BTO:0004108 +xref: FMA:67609 +is_a: CL:0000164 ! enteroendocrine cell +is_a: CL:0000506 ! enkephalin secreting cell +is_a: CL:0000509 ! gastrin secreting cell +is_a: CL:0002180 ! mucous cell of stomach +relationship: BFO:0000050 UBERON:0004997 ! part of mucosa of pyloric antrum + +[Term] +id: CL:0000509 +name: gastrin secreting cell +def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm] +is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000513 name: cardiac muscle myoblast +def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:D032386] +xref: FMA:84797 is_a: CL:0002494 ! cardiocyte is_a: CL:0010021 ! cardiac myoblast intersection_of: CL:0000056 ! myoblast @@ -1152,6 +1604,8 @@ relationship: BFO:0000050 UBERON:0001133 ! part of cardiac muscle tissue [Term] id: CL:0000514 name: smooth muscle myoblast +def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:D032390] +xref: FMA:84798 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000192 ! smooth muscle cell @@ -1160,6 +1614,8 @@ relationship: RO:0002203 CL:0000192 ! smooth muscle cell [Term] id: CL:0000515 name: skeletal muscle myoblast +def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl] +xref: FMA:84799 is_a: CL:0000056 ! myoblast is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000056 ! myoblast @@ -1170,6 +1626,7 @@ relationship: RO:0002203 CL:0008002 ! skeletal muscle fiber [Term] id: CL:0000518 name: phagocyte (sensu Vertebrata) +def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm] is_a: CL:0000234 ! phagocyte is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -1177,6 +1634,7 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: CL:0000521 name: fungal cell +def: "Any cell that only exists in Fungi." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002160 NCBITaxon:4751 ! Fungi @@ -1185,36 +1643,53 @@ relationship: RO:0002160 NCBITaxon:4751 ! Fungi [Term] id: CL:0000525 name: syncytiotrophoblast cell +def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] +xref: FMA:83043 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000351 ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: RO:0000053 PATO:0001908 ! bearer of relationship: BFO:0000050 UBERON:0000371 ! part of syncytiotrophoblast -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000526 name: afferent neuron +def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:D009475] +xref: FMA:87653 is_a: CL:0000540 ! neuron -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000527 name: efferent neuron +def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:D009476] is_a: CL:0000540 ! neuron [Term] id: CL:0000540 name: neuron +def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:D009474] +comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. +xref: BTO:0000938 +xref: CALOHA:TS-0683 +xref: FMA:54527 +xref: VHOG:0001483 +xref: WBbt:0003679 is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell +relationship: RO:0002202 CL:0000031 {gci_filler="NCBITaxon:7742", gci_relation="RO:0002162", xref="https://github.com/obophenotype/cell-ontology/issues/757"} ! neuroblast (sensu Vertebrata) relationship: RO:0002215 GO:0019226 ! capable of transmission of nerve impulse -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000542 name: lymphocyte +def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149] +comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) +xref: BTO:0000775 +xref: CALOHA:TS-0583 +xref: FMA:62863 +xref: MESH:D008214 +xref: VHOG:0001535 is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000738 ! leukocyte intersection_of: BFO:0000051 CL:0017500 ! has part neutrophillic cytoplasm @@ -1226,11 +1701,12 @@ relationship: BFO:0000051 CL:0017500 ! has part neutrophillic cytoplasm relationship: BFO:0000051 GO:0000792 ! has part heterochromatin relationship: RO:0000053 PATO:0040072 ! bearer of relationship: RO:0002202 CL:0000051 ! common lymphoid progenitor -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000547 name: proerythroblast +def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, PMID:1638021] +xref: FMA:83518 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell @@ -1270,6 +1746,8 @@ relationship: RO:0002202 CL:0000038 ! erythroid progenitor cell [Term] id: CL:0000549 name: basophilic erythroblast +def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464] +xref: FMA:83505 is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm @@ -1282,6 +1760,8 @@ relationship: RO:0002104 PR:000001945 [Term] id: CL:0000550 name: polychromatophilic erythroblast +def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464] +xref: FMA:83506 is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017504 ! has part polychromatophilic cytoplasm @@ -1295,6 +1775,8 @@ relationship: RO:0002202 CL:0000549 ! basophilic erythroblast [Term] id: CL:0000552 name: orthochromatic erythroblast +def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464] +xref: FMA:84646 is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm @@ -1306,6 +1788,12 @@ relationship: RO:0002202 CL:0000550 ! polychromatophilic erythroblast [Term] id: CL:0000553 name: megakaryocyte progenitor cell +def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464] +comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. +xref: BTO:0001164 +xref: CALOHA:TS-0610 +xref: FMA:84235 +xref: MESH:D055016 is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell @@ -1338,20 +1826,25 @@ relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: RO:0002215 GO:0007113 ! capable of endomitotic cell cycle relationship: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000556 name: megakaryocyte +def: "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533, PMID:31043076] +comment: Megakaryocytes are reportedly CD181-positive and CD182-positive. +xref: BTO:0000843 +xref: CALOHA:TS-0611 +xref: FMA:83555 is_a: CL:0000763 ! myeloid cell disjoint_from: CL:0000764 ! erythroid lineage cell relationship: RO:0000053 PATO:0001393 ! bearer of relationship: RO:0002202 CL:0000553 ! megakaryocyte progenitor cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000557 name: granulocyte monocyte progenitor cell +def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/CFU-GM, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251, PMID:16647566] +comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. is_a: CL:0000763 ! myeloid cell is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor is_a: CL:0011026 ! progenitor cell @@ -1372,11 +1865,14 @@ relationship: CL:4030045 PR:000007858 ! lacks_part relationship: RO:0002104 PR:000001865 relationship: RO:0002215 GO:0030225 ! capable of macrophage differentiation relationship: RO:0002215 GO:0030851 ! capable of granulocyte differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000558 name: reticulocyte +def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622] +xref: BTO:0001173 +xref: CALOHA:TS-0864 +xref: MESH:D012156 is_a: CL:0000764 ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part @@ -1410,6 +1906,10 @@ relationship: RO:0002215 GO:0071971 ! capable of extracellular exosome assembly [Term] id: CL:0000559 name: promonocyte +def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [GOC:tfm, ISBN:0721601464] +comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. +xref: BTO:0004657 +xref: FMA:83551 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell @@ -1419,11 +1919,11 @@ intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: BFO:0000051 GO:0042582 ! has part azurophil granule relationship: RO:0002104 PR:000001012 relationship: RO:0002202 CL:0000040 ! monoblast -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000562 name: nucleate erythrocyte +def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm] is_a: CL:0000232 ! erythrocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000232 ! erythrocyte @@ -1433,6 +1933,8 @@ relationship: RO:0002202 CL:0002421 ! nucleated reticulocyte [Term] id: CL:0000566 name: angioblastic mesenchymal cell +def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659] +comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000134 ! mesenchymal stem cell @@ -1447,6 +1949,7 @@ relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000569 name: cardiac mesenchymal cell +def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864] is_a: CL:0008019 ! mesenchymal cell is_a: CL:2000073 ! migratory cardiac neural crest cell intersection_of: CL:0008019 ! mesenchymal cell @@ -1456,23 +1959,34 @@ relationship: RO:0002203 CL:0002494 ! cardiocyte [Term] id: CL:0000573 name: retinal cone cell +def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:D017949] +xref: BTO:0001036 +xref: CALOHA:TS-0866 +xref: FMA:67748 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: RO:0002202 CL:0002672 ! retinal progenitor cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000575 name: corneal epithelial cell +def: "An epithelial cell of the cornea." [GOC:tfm] +xref: BTO:0004298 +xref: CALOHA:TS-0173 +xref: FMA:70551 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0001772 ! part of corneal epithelium relationship: BFO:0000050 UBERON:0001772 ! part of corneal epithelium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000576 name: monocyte +def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:D009000] +comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. +xref: BTO:0000876 +xref: CALOHA:TS-0638 +xref: FMA:62864 is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0011026 ! progenitor cell @@ -1485,11 +1999,16 @@ relationship: RO:0002202 CL:0000559 ! promonocyte relationship: RO:0002215 GO:0030225 ! capable of macrophage differentiation relationship: RO:0002215 GO:0030316 ! capable of osteoclast differentiation relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000583 name: alveolar macrophage +def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [GO_REF:0000031, GOC:ana, GOC:dsd, GOC:tfm, MESH:D016676] +comment: A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8. {xref="https://doi.org/10.5281/zenodo.11165918"} +comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. +xref: BTO:0000802 +xref: CALOHA:TS-0030 +xref: FMA:83023 is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:1001603 ! lung macrophage intersection_of: CL:0000864 ! tissue-resident macrophage @@ -1511,18 +2030,24 @@ relationship: RO:0002104 PR:000001813 relationship: RO:0002104 PR:000001931 relationship: RO:0002104 PR:000002064 relationship: RO:0002104 PR:000002972 +relationship: RO:0015004 CL:4037003 ! has characterizing marker set NS forest marker set of alveolar macrophage (Human Lung). relationship: RO:0015016 PR:000001012 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000586 name: germ cell +def: "The reproductive cell in multicellular organisms." [MESH:D005854] +xref: BTO:0000535 +xref: NCIT:C12597 +xref: VHOG:0001534 +xref: WBbt:0006796 is_a: CL:0000039 ! germ line cell relationship: RO:0002216 GO:0009566 ! capable of part of fertilization [Term] id: CL:0000593 name: androgen secreting cell +def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm] is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035935 ! capable of androgen secretion @@ -1531,32 +2056,62 @@ relationship: RO:0002215 GO:0035935 ! capable of androgen secretion [Term] id: CL:0000604 name: retinal rod cell +def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:D017948] +xref: BTO:0001024 +xref: CALOHA:TS-0870 +xref: FMA:67747 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: RO:0002202 CL:0002672 ! retinal progenitor cell -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0000622 +name: acinar cell +def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de] +xref: FMA:83625 +xref: MESH:D061354 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0000154 ! protein secreting cell +relationship: BFO:0000050 UBERON:0009842 ! part of glandular acinus [Term] id: CL:0000630 name: supporting cell +def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm] +xref: BTO:0002315 is_a: CL:0000000 ! cell +[Term] +id: CL:0000666 +name: fenestrated endothelial cell +def: "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." [DOI:10.1007/978-3-211-99390-3_133] +is_a: CL:0000115 ! endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: RO:0000053 PATO:0002064 ! bearer of +relationship: RO:0000053 PATO:0002064 ! bearer of + [Term] id: CL:0000667 name: collagen secreting cell +def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000669 name: pericyte +def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." [GOC:dsd, GOC:tfm, ISBN:0721662544, MESH:D020286, PMID:16807374, PMID:17986482, PMID:20024907] +comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A. +xref: BTO:0002441 +xref: FMA:63174 is_a: CL:0000183 ! contractile cell is_a: CL:0000630 ! supporting cell is_a: CL:0002320 ! connective tissue cell is_a: CL:0008034 ! mural cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000670 name: primordial germ cell +def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289] +xref: FMA:70567 is_a: CL:0000039 ! germ line cell is_a: CL:0000219 ! motile cell intersection_of: CL:0000039 ! germ line cell @@ -1567,12 +2122,14 @@ relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: CL:0000675 name: female gamete +def: "A mature sexual reproductive cell of the female germline." [GOC:tfm] is_a: CL:0000021 ! female germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000680 name: muscle precursor cell +def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add] is_a: BFO:0000002 is_a: CL:0000055 ! non-terminally differentiated cell intersection_of: CL:0011115 ! precursor cell @@ -1583,12 +2140,19 @@ relationship: RO:0002203 CL:0000187 ! muscle cell [Term] id: CL:0000696 name: PP cell +def: "A cell that stores and secretes pancreatic polypeptide hormone." [GOC:tfm, JB:jb, PMID:15153415] +xref: FMA:62938 +xref: FMA:83409 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000710 name: neurecto-epithelial cell +def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm] +comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). +xref: BTO:0004301 +xref: FMA:70557 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell intersection_of: CL:0002077 ! ecto-epithelial cell @@ -1598,6 +2162,9 @@ relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0000723 name: somatic stem cell +def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103] +xref: CALOHA:TS-2086 +xref: MESH:D053687 is_a: CL:0000034 ! stem cell intersection_of: CL:0000034 ! stem cell intersection_of: RO:0002215 GO:0048103 ! capable of somatic stem cell division @@ -1606,6 +2173,10 @@ relationship: RO:0002215 GO:0048103 ! capable of somatic stem cell division [Term] id: CL:0000737 name: striated muscle cell +def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544] +xref: BTO:0002916 +xref: CALOHA:TS-2157 +xref: FMA:86936 is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere @@ -1617,6 +2188,12 @@ relationship: RO:0000053 PATO:0001410 ! bearer of [Term] id: CL:0000738 name: leukocyte +def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0] +xref: BTO:0000751 +xref: CALOHA:TS-0549 +xref: FMA:62852 +xref: MESH:D007962 +xref: NCIT:C12529 is_a: BFO:0000002 is_a: CL:0000219 ! motile cell is_a: CL:0000255 ! eukaryotic cell @@ -1629,18 +2206,26 @@ relationship: BFO:0000050 UBERON:0002405 ! part of immune system relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002202 CL:0000037 ! hematopoietic stem cell relationship: RO:0002215 GO:0001667 ! capable of ameboidal-type cell migration -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000740 name: retinal ganglion cell +def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph] +xref: BTO:0001800 +xref: FMA:67765 +xref: MESH:D012165 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) relationship: RO:0002100 UBERON:0000966 ! retina -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000746 name: cardiac muscle cell +def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263] +comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. +xref: BTO:0001539 +xref: CALOHA:TS-0115 +xref: FMA:14067 +xref: MESH:D032383 is_a: CL:0000737 ! striated muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000187 ! muscle cell @@ -1651,11 +2236,14 @@ intersection_of: RO:0000056 GO:0060047 ! participates in heart contraction relationship: RO:0000053 PATO:0002478 ! bearer of relationship: RO:0000056 GO:0060047 ! participates in heart contraction relationship: RO:0002202 CL:0000513 ! cardiac muscle myoblast -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000763 name: myeloid cell +def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add] +xref: BTO:0001441 +xref: CALOHA:TS-0647 +xref: MESH:D022423 is_a: BFO:0000002 is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell @@ -1665,12 +2253,21 @@ relationship: RO:0002202 CL:0000049 ! common myeloid progenitor [Term] id: CL:0000764 name: erythroid lineage cell +def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm] +comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. +xref: CALOHA:TS-0290 +xref: FMA:62845 +xref: FMA:83516 is_a: CL:0000763 ! myeloid cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000765 name: erythroblast +def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176] +xref: BTO:0001571 +xref: CALOHA:TS-0289 +xref: FMA:83504 +xref: MESH:D004900 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000764 ! erythroid lineage cell @@ -1707,6 +2304,7 @@ relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation [Term] id: CL:0000766 name: myeloid leukocyte +def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add] is_a: CL:0000738 ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte @@ -1715,6 +2313,8 @@ intersection_of: RO:0002202 CL:0000049 ! common myeloid progenitor [Term] id: CL:0000778 name: mononuclear osteoclast +def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452] +comment: Morphology: mononuclear, highly vesicular. is_a: CL:0000092 ! osteoclast is_a: CL:0000113 ! mononuclear phagocyte intersection_of: CL:0000092 ! osteoclast @@ -1723,6 +2323,8 @@ intersection_of: RO:0000053 PATO:0001407 ! bearer of [Term] id: CL:0000779 name: multinuclear osteoclast +def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:9415452] +comment: Morphology: multinucleated, highly vesicular. is_a: CL:0000092 ! osteoclast is_a: CL:0000783 ! multinucleated phagocyte intersection_of: CL:0000092 ! osteoclast @@ -1732,6 +2334,9 @@ relationship: RO:0002202 CL:0000778 ! mononuclear osteoclast [Term] id: CL:0000782 name: myeloid dendritic cell +def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319] +comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). +xref: BTO:0004721 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell @@ -1743,6 +2348,7 @@ relationship: RO:0002202 CL:0000763 ! myeloid cell [Term] id: CL:0000783 name: multinucleated phagocyte +def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) @@ -1751,6 +2357,7 @@ intersection_of: RO:0000053 PATO:0001908 ! bearer of [Term] id: CL:0000827 name: pro-T cell +def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149] is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030217 ! capable of T cell differentiation @@ -1760,6 +2367,9 @@ relationship: RO:0002215 GO:0030217 ! capable of T cell differentiation [Term] id: CL:0000835 name: myeloblast +def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [GOC:add, http://en.wikipedia.org/wiki/Myeloblast, http://www.cap.org, ISBN:0721601464] +xref: BTO:0000187 +xref: FMA:83524 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell @@ -1776,6 +2386,10 @@ relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell +def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770] +comment: Markers differ between mouse and human. +xref: BTO:0000725 +xref: CALOHA:TS-0448 is_a: BFO:0000002 is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell @@ -1811,11 +2425,15 @@ relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part relationship: RO:0000053 PATO:0001402 ! bearer of relationship: RO:0002104 PR:000001003 relationship: RO:0002202 CL:0000037 ! hematopoietic stem cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000838 name: lymphoid lineage restricted progenitor cell +def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm] +comment: Note that this is a class of cell types, not an identified single cell type. +xref: BTO:0004731 +xref: CALOHA:TS-2025 +xref: FMA:70338 is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell @@ -1826,16 +2444,24 @@ relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell +def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770] +comment: Note that this is a class of cell types, not an identified single cell type. +xref: BTO:0004730 +xref: CALOHA:TS-2099 +xref: FMA:70339 is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030099 ! capable of myeloid cell differentiation relationship: RO:0002215 GO:0030099 ! capable of myeloid cell differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000842 name: mononuclear cell +def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] +xref: BTO:0000878 +xref: CALOHA:TS-0768 +xref: FMA:86713 is_a: CL:0000226 ! single nucleate cell is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte @@ -1844,6 +2470,8 @@ intersection_of: RO:0000053 PATO:0001407 ! bearer of [Term] id: CL:0000860 name: classical monocyte +def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] +comment: Markers: CCR2+CXCCR1 (human, mouse, rat). is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part @@ -1859,11 +2487,14 @@ relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part relationship: RO:0002215 GO:0002548 ! capable of monocyte chemotaxis relationship: RO:0002215 GO:0006954 ! capable of inflammatory response relationship: RO:0015015 PR:000001199 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000861 name: elicited macrophage +def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [GO_REF:0000031, GOC:add, GOC:ana, GOC:tfm, PMID:15771589] +comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). +xref: FMA:84643 +xref: FMA:84645 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: RO:0000056 GO:0006954 ! participates in inflammatory response @@ -1879,6 +2510,8 @@ relationship: RO:0002202 CL:0000860 ! classical monocyte [Term] id: CL:0000862 name: suppressor macrophage +def: "A macrophage that suppresses immune responses." [GOC:add, GOC:tfm, PMID:20402419] +comment: Markers: May express: IL10, TGFbeta. is_a: CL:0000861 ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response @@ -1887,6 +2520,9 @@ relationship: RO:0002215 GO:0050777 ! capable of negative regulation of immune r [Term] id: CL:0000864 name: tissue-resident macrophage +def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654] +xref: FMA:84642 +xref: FMA:84644 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0000479 ! part of tissue @@ -1895,6 +2531,7 @@ relationship: BFO:0000050 UBERON:0000479 ! part of tissue [Term] id: CL:0000878 name: central nervous system macrophage +def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, PMID:16322748] is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:0002319 ! neural cell intersection_of: CL:0000864 ! tissue-resident macrophage @@ -1904,6 +2541,8 @@ relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system [Term] id: CL:0000936 name: early lymphoid progenitor +def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:19022770] +comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell @@ -1919,25 +2558,32 @@ relationship: RO:0002104 PR:000002065 relationship: RO:0002104 PR:000002979 relationship: RO:0002202 CL:0002035 ! Slamf1-negative multipotent progenitor cell relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000988 name: hematopoietic cell +def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add] +xref: BTO:0000574 +xref: CALOHA:TS-2017 +xref: FMA:70366 +xref: FMA:83598 is_a: CL:0000000 ! cell [Term] id: CL:0000990 name: conventional dendritic cell +def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [GO_REF:0000031, GOC:amm, PMID:17850486] +comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. +xref: FMA:84191 is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: RO:0015015 PR:000001013 relationship: RO:0015015 PR:000001013 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000995 name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor +comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor @@ -1945,6 +2591,8 @@ union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0001008 name: Kit and Sca1-positive hematopoietic stem cell +def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:17952047, PMID:19022770] +comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617). is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part @@ -1971,6 +2619,7 @@ relationship: RO:0002104 PR:000002979 [Term] id: CL:0001012 name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor +comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0000557 ! granulocyte monocyte progenitor cell union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell @@ -1978,6 +2627,7 @@ union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001019 name: CD115-positive monocyte OR common dendritic progenitor +comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell union_of: CL:0001022 ! CD115-positive monocyte union_of: CL:0001029 ! common dendritic progenitor @@ -1985,6 +2635,8 @@ union_of: CL:0001029 ! common dendritic progenitor [Term] id: CL:0001021 name: CD34-positive, CD38-positive common lymphoid progenitor +def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMCID:PMC2346585, PMID:19022770] +comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617). is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor @@ -2002,6 +2654,8 @@ relationship: RO:0002202 CL:0002043 ! CD34-positive, CD38-negative multipotent p [Term] id: CL:0001022 name: CD115-positive monocyte +def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047] +comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). is_a: CL:0000576 ! monocyte is_a: CL:0000839 ! myeloid lineage restricted progenitor cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor @@ -2015,6 +2669,8 @@ relationship: RO:0002202 CL:0002001 ! CD34-positive, CD38-positive granulocyte m [Term] id: CL:0001023 name: Kit-positive, CD34-positive common myeloid progenitor +def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:1261582, PMID:17952047] +comment: Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617). is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive @@ -2034,6 +2690,9 @@ relationship: RO:0015016 PR:000001481 [Term] id: CL:0001024 name: CD34-positive, CD38-negative hematopoietic stem cell +def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:10430905, PMID:11750107, PMID:16551251, PMID:20024907, PMID:9389721] +comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617). +xref: CALOHA:TS-0448 is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part @@ -2057,6 +2716,8 @@ relationship: RO:0002104 PR:000001843 [Term] id: CL:0001025 name: Kit-positive, Sca1-positive common lymphoid progenitor +def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17952047] +comment: Markers are associated with mouse cells. is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor @@ -2079,6 +2740,8 @@ relationship: RO:0015016 PR:000002979 [Term] id: CL:0001026 name: CD34-positive, CD38-positive common myeloid progenitor +def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [GO_REF:0000031, GOC:add, GOC:amm, PMCID:PMC2626675, PMID:16551251] +comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617). is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive @@ -2099,6 +2762,8 @@ relationship: RO:0015016 PR:000001865 [Term] id: CL:0001027 name: CD7-negative lymphoid progenitor cell +def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251] +comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617). is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor intersection_of: CL:0000051 ! common lymphoid progenitor @@ -2113,6 +2778,8 @@ relationship: RO:0002202 CL:0001021 ! CD34-positive, CD38-positive common lympho [Term] id: CL:0001028 name: CD7-positive lymphoid progenitor cell +def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395] +comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). is_a: CL:0000051 ! common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part @@ -2126,6 +2793,8 @@ relationship: RO:0002202 CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001029 name: common dendritic progenitor +def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519] +comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). is_a: CL:0000763 ! myeloid cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell @@ -2164,6 +2833,7 @@ relationship: RO:0015016 PR:000002065 [Term] id: CL:0001030 name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor +comment: Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor @@ -2171,15 +2841,17 @@ union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor [Term] id: CL:0001035 name: bone cell +def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element relationship: BFO:0000050 UBERON:0001474 ! part of bone element -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001054 name: CD14-positive monocyte +def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [GOC:add, PMID:22343568] +comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part @@ -2190,11 +2862,12 @@ relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part relationship: RO:0002104 PR:000001889 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001059 name: common myeloid progenitor, CD34-positive +def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566] +comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. is_a: CL:0000049 ! common myeloid progenitor is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000049 ! common myeloid progenitor @@ -2215,6 +2888,7 @@ relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differen [Term] id: CL:0001060 name: hematopoietic oligopotent progenitor cell, lineage-negative +def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part @@ -2246,6 +2920,8 @@ relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part [Term] id: CL:0001066 name: erythroid progenitor cell, mammalian +def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] +xref: BTO:0004911 is_a: CL:0000038 ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part @@ -2278,6 +2954,8 @@ relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation [Term] id: CL:0002000 name: Kit-positive erythroid progenitor cell +def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19805084] +comment: Markers found on mouse cells. is_a: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:4030046 GO:0033001 ! lacks_plasma_membrane_part Fc-gamma receptor III complex @@ -2301,6 +2979,8 @@ relationship: RO:0002202 CL:0002006 ! Kit-positive, CD34-negative megakaryocyte [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor +def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770] +comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. is_a: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: RO:0002104 PR:000001003 @@ -2313,6 +2993,8 @@ relationship: RO:0002202 CL:0001026 ! CD34-positive, CD38-positive common myeloi [Term] id: CL:0002002 name: Kit-positive granulocyte monocyte progenitor +def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:16322423, PMID:19022770, PMID:19273628] +comment: Markers are found on mouse cells. is_a: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part @@ -2336,6 +3018,9 @@ relationship: RO:0015015 PR:000001479 [Term] id: CL:0002003 name: CD34-positive, GlyA-negative erythroid progenitor cell +def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] +comment: Cell markers associated with human cells. +xref: FMA:83517 is_a: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part @@ -2347,6 +3032,8 @@ relationship: RO:0002202 CL:0002005 ! CD34-positive, CD38-positive megakaryocyte [Term] id: CL:0002004 name: CD34-negative, GlyA-negative proerythroblast +def: "A proerythoblast that is CD34-negative and GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] +comment: Cell surface markers are associated with human cells. is_a: CL:0000547 ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part @@ -2358,6 +3045,8 @@ relationship: RO:0002202 CL:0002003 ! CD34-positive, GlyA-negative erythroid pro [Term] id: CL:0002005 name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell +def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700] +comment: Markers are associated with human cell type. is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part @@ -2372,6 +3061,8 @@ relationship: RO:0002104 PR:000001408 [Term] id: CL:0002006 name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell +def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:19022770] +comment: Markers are associated with mouse cells. is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part @@ -2392,6 +3083,7 @@ relationship: RO:0015016 GO:0033001 ! Fc-gamma receptor III complex [Term] id: CL:0002009 name: macrophage dendritic cell progenitor +def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [GOC:tfm, PMID:19273628] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell @@ -2405,6 +3097,7 @@ relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differen [Term] id: CL:0002010 name: pre-conventional dendritic cell +def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [GOC:tfm] is_a: CL:0000763 ! myeloid cell is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell @@ -2445,6 +3138,8 @@ relationship: RO:0002202 CL:0001029 ! common dendritic progenitor [Term] id: CL:0002011 name: Kit-positive macrophage dendritic cell progenitor +def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [GOC:tfm, PMID:19273628] +comment: Markers are associated with mouse cells. is_a: CL:0002009 ! macrophage dendritic cell progenitor intersection_of: CL:0002009 ! macrophage dendritic cell progenitor intersection_of: RO:0002104 PR:000001206 @@ -2460,6 +3155,8 @@ relationship: RO:0015015 PR:000002065 [Term] id: CL:0002012 name: Kit-low proerythroblast +def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [GOC:ak, GOC:tfm, PMID:19805084] +comment: Markers are associated with mouse cells. is_a: CL:0000547 ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part @@ -2477,6 +3174,8 @@ relationship: RO:0015016 PR:000002065 [Term] id: CL:0002013 name: GlyA-positive basophilic erythroblast +def: "A basophilic erythroblast that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] +comment: Markers are associated with human cells. is_a: CL:0000549 ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part @@ -2488,6 +3187,8 @@ relationship: RO:0002202 CL:0002004 ! CD34-negative, GlyA-negative proerythrobla [Term] id: CL:0002014 name: Kit-negative, Ly-76 high basophilic erythroblast +def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] +comment: Cell surface markers are associated with mouse cells. is_a: CL:0000549 ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part @@ -2503,6 +3204,7 @@ relationship: RO:0015015 PR:000002981 [Term] id: CL:0002015 name: Kit-negative, Ly-76 high polychromatophilic erythroblast +def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] is_a: CL:0000550 ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part @@ -2518,6 +3220,8 @@ relationship: RO:0015015 PR:000002981 [Term] id: CL:0002016 name: CD71-low, GlyA-positive polychromatic erythroblast +def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." [GOC:ak, GOC:tfm, PMID:1638021] +comment: Cell surface markers are associated with human cells. is_a: CL:0000550 ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: RO:0002104 PR:000001460 @@ -2529,6 +3233,8 @@ relationship: RO:0015016 PR:000001945 [Term] id: CL:0002017 name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts +def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] +comment: Cell surface markers associated with mouse cells. is_a: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part @@ -2546,6 +3252,8 @@ relationship: RO:0015016 PR:000001945 [Term] id: CL:0002018 name: CD71-negative, GlyA-positive orthochromatic erythroblast +def: "An erythroblast that is GlyA-positive and CD71-negative." [GOC:ak, GOC:tfm, PMID:1638021] +comment: Markers associated with human cells. is_a: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part @@ -2557,6 +3265,7 @@ relationship: RO:0002202 CL:0002016 ! CD71-low, GlyA-positive polychromatic eryt [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell +def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] is_a: BFO:0000002 is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell @@ -2568,6 +3277,8 @@ relationship: RO:0002202 CL:0002032 ! hematopoietic oligopotent progenitor cell [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell +def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770] +comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). is_a: BFO:0000002 is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell @@ -2578,6 +3289,8 @@ relationship: RO:0002202 CL:0000837 ! hematopoietic multipotent progenitor cell [Term] id: CL:0002033 name: short term hematopoietic stem cell +def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [GOC:tfm, PMID:15572596, PMID:19022770] +comment: Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low. is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part @@ -2590,6 +3303,8 @@ relationship: RO:0002202 CL:0002034 ! long term hematopoietic stem cell [Term] id: CL:0002034 name: long term hematopoietic stem cell +def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [GOC:tfm, PMID:15572596, PMID:17582345] +comment: Markers are associated with mouse cells. is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part @@ -2603,6 +3318,8 @@ relationship: RO:0015016 PR:000001843 [Term] id: CL:0002035 name: Slamf1-negative multipotent progenitor cell +def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [GOC:tfm, PMID:19022770] +comment: Markers are associated with mouse cells. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part @@ -2618,6 +3335,8 @@ relationship: RO:0002202 CL:0002036 ! Slamf1-positive multipotent progenitor cel [Term] id: CL:0002036 name: Slamf1-positive multipotent progenitor cell +def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [GOC:tfm, PMID:19022770] +comment: Markers are associated with mouse cells. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: RO:0002104 PR:000001833 @@ -2632,6 +3351,8 @@ relationship: RO:0002202 CL:0002033 ! short term hematopoietic stem cell [Term] id: CL:0002043 name: CD34-positive, CD38-negative multipotent progenitor cell +def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [GOC:tfm, PMID:18371405, PMID:19022770] +comment: Cell markers are associated with human hematopoietic multipotent progenitor cells. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part @@ -2646,15 +3367,20 @@ relationship: RO:0002202 CL:0001024 ! CD34-positive, CD38-negative hematopoietic [Term] id: CL:0002062 name: pulmonary alveolar type 1 cell +def: "A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." [GOC:tfm, http://www.copewithcytokines.de, PMID:20054144, PMID:29463737] +xref: BTO:0000780 +xref: FMA:62500 is_a: CL:0000322 ! pulmonary alveolar epithelial cell intersection_of: CL:0000322 ! pulmonary alveolar epithelial cell intersection_of: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system relationship: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002063 name: pulmonary alveolar type 2 cell +def: "A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." [GOC:tfm, http://www.copewithcytokines.de, ISBN:0412046911, PMID:36138472, PMID:8540632] +xref: BTO:0000538 +xref: FMA:62501 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0000322 ! pulmonary alveolar epithelial cell is_a: CL:1000272 ! lung secretory cell @@ -2662,11 +3388,26 @@ intersection_of: CL:0000322 ! pulmonary alveolar epithelial cell intersection_of: RO:0002215 GO:0032940 ! capable of secretion by cell intersection_of: RO:0002215 GO:0043129 ! capable of surfactant homeostasis relationship: RO:0002202 CL:4040003 ! fetal pre-type II pulmonary alveolar epithelial cell -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0002064 +name: pancreatic acinar cell +def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells, ISBN:0517223651, PMID:20395539] +xref: BTO:0000028 +xref: CALOHA:TS-0737 +xref: FMA:63032 +is_a: CL:0000622 ! acinar cell +is_a: CL:1001599 ! pancreas exocrine glandular cell +intersection_of: CL:0000622 ! acinar cell +intersection_of: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus +relationship: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus +relationship: BFO:0000051 GO:0042589 ! has part zymogen granule membrane [Term] id: CL:0002067 name: type A enteroendocrine cell +def: "An enteroendocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911] +xref: FMA:62939 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell intersection_of: CL:0000164 ! enteroendocrine cell @@ -2675,28 +3416,39 @@ intersection_of: RO:0002215 GO:0070091 ! capable of glucagon secretion [Term] id: CL:0002068 name: Purkinje myocyte +def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742] +xref: BTO:0001032 +xref: FMA:14146 is_a: CL:0002086 ! specialized cardiac myocyte -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002072 name: nodal myocyte +def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm] +xref: BTO:0004190 +xref: FMA:67101 is_a: CL:0002086 ! specialized cardiac myocyte [Term] id: CL:0002073 name: transitional myocyte +def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm] +xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte [Term] id: CL:0002074 name: myocardial endocrine cell +def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm] +xref: FMA:67111 is_a: CL:0000163 ! endocrine cell is_a: CL:0002086 ! specialized cardiac myocyte [Term] id: CL:0002076 name: endo-epithelial cell +def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm] +xref: FMA:69075 is_a: BFO:0000002 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell @@ -2706,6 +3458,8 @@ relationship: RO:0002202 CL:0000223 ! endodermal cell [Term] id: CL:0002077 name: ecto-epithelial cell +def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm] +xref: FMA:69074 is_a: BFO:0000002 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell @@ -2715,28 +3469,76 @@ relationship: RO:0002202 CL:0000221 ! ectodermal cell [Term] id: CL:0002078 name: meso-epithelial cell +def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm] +xref: FMA:69076 is_a: BFO:0000002 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002202 CL:0000222 ! mesodermal cell relationship: RO:0002202 CL:0000222 ! mesodermal cell +[Term] +id: CL:0002079 +name: pancreatic ductal cell +def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223] +xref: FMA:63099 +is_a: CL:0000069 ! branched duct epithelial cell +is_a: CL:1001433 ! epithelial cell of exocrine pancreas +intersection_of: CL:0000083 ! epithelial cell of pancreas +intersection_of: BFO:0000050 UBERON:0001064 ! part of ventral pancreatic duct +intersection_of: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity +relationship: BFO:0000050 UBERON:0001064 ! part of ventral pancreatic duct +relationship: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity + +[Term] +id: CL:0002080 +name: pancreatic centro-acinar cell +def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160] +xref: FMA:62455 +is_a: CL:1001433 ! epithelial cell of exocrine pancreas +intersection_of: CL:0000083 ! epithelial cell of pancreas +intersection_of: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus +intersection_of: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity +relationship: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus +relationship: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity + [Term] id: CL:0002086 name: specialized cardiac myocyte +def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm] +xref: FMA:67968 is_a: CL:0000746 ! cardiac muscle cell [Term] id: CL:0002087 name: nongranular leukocyte +def: "A leukocyte that lacks granules." [GOC:tfm] +xref: FMA:62855 is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: CL:4030045 GO:0030141 ! lacks_part secretory granule relationship: CL:4030045 GO:0030141 ! lacks_part secretory granule +[Term] +id: CL:0002088 +name: interstitial cell of Cajal +def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112] +comment: Some argue this cell type is of mesenchymal origin. +xref: BTO:0003914 +xref: FMA:86573 +is_a: CL:0000710 ! neurecto-epithelial cell +intersection_of: CL:0000710 ! neurecto-epithelial cell +intersection_of: RO:0002215 GO:0043134 ! capable of regulation of hindgut contraction +relationship: RO:0002215 GO:0043134 ! capable of regulation of hindgut contraction + [Term] id: CL:0002092 name: bone marrow cell +def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256] +comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. +xref: BTO:0004850 +xref: FMA:83621 +xref: MESH:D001854 is_a: CL:0001035 ! bone cell intersection_of: CL:0001035 ! bone cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow @@ -2745,13 +3547,16 @@ relationship: BFO:0000050 UBERON:0002371 ! part of bone marrow [Term] id: CL:0002095 name: hilus cell of ovary +def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X] +xref: FMA:18710 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002132 ! stromal cell of ovary -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002132 name: stromal cell of ovary +def: "A stomal cell of the ovary" [GOC:tfm] +xref: FMA:72299 is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary @@ -2760,35 +3565,48 @@ relationship: BFO:0000050 UBERON:0000992 ! part of ovary [Term] id: CL:0002139 name: endothelial cell of vascular tree +def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659] +comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. +xref: BTO:0001854 +xref: CALOHA:TS-1106 +xref: FMA:67755 is_a: CL:0000115 ! endothelial cell [Term] id: CL:0002144 name: capillary endothelial cell +def: "An endothelial cell found in capillaries." [GOC:tfm] +xref: BTO:0004956 +xref: CALOHA:TS-0112 +xref: FMA:67756 is_a: CL:0002653 ! squamous endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0001915 ! part of endothelium of capillary relationship: BFO:0000050 UBERON:0001915 ! part of endothelium of capillary -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002145 name: ciliated columnar cell of tracheobronchial tree +def: "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." [GOC:tfm, ISBN:0517223651] +xref: FMA:70542 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0005012 ! multi-ciliated epithelial cell is_a: CL:4030034 ! respiratory ciliated cell relationship: RO:0002202 CL:0002209 ! intermediate epitheliocyte -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002159 name: general ecto-epithelial cell +def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm] +xref: FMA:70556 is_a: CL:0002077 ! ecto-epithelial cell [Term] id: CL:0002178 name: epithelial cell of stomach +def: "An epithelial cell found in the lining of the stomach." [GOC:tfm] +xref: FMA:62948 is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach @@ -2797,6 +3615,8 @@ relationship: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: CL:0002180 name: mucous cell of stomach +def: "A mucous cell in the epithelium of the stomach." [GOC:tfm] +xref: FMA:63464 is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002178 ! epithelial cell of stomach intersection_of: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach @@ -2805,6 +3625,8 @@ relationship: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach [Term] id: CL:0002183 name: stem cell of gastric gland +def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651] +xref: FMA:62953 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000152 ! exocrine cell is_a: CL:0002180 ! mucous cell of stomach @@ -2815,6 +3637,8 @@ relationship: BFO:0000050 UBERON:0000325 ! part of gastric gland [Term] id: CL:0002191 name: granulocytopoietic cell +def: "A cell involved in the formation of a granulocyte." [GOC:tfm] +xref: FMA:83519 is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030851 ! capable of granulocyte differentiation @@ -2823,14 +3647,28 @@ relationship: RO:0002215 GO:0030851 ! capable of granulocyte differentiation [Term] id: CL:0002194 name: monopoietic cell +def: "A cell involved in the formation of a monocyte (monopoiesis)." [GOC:tfm] +xref: FMA:83552 is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: RO:0002215 GO:0030224 ! capable of monocyte differentiation +[Term] +id: CL:0002195 +name: hepatic stem cell +def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." [GOC:tfm, PMID:26798363] +xref: FMA:86577 +is_a: CL:0000048 ! multi fate stem cell +intersection_of: CL:0000048 ! multi fate stem cell +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: CL:0002202 name: epithelial cell of tracheobronchial tree +def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm] +xref: FMA:66816 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium @@ -2839,11 +3677,15 @@ relationship: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium [Term] id: CL:0002209 name: intermediate epitheliocyte +def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651] +xref: FMA:69060 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree [Term] id: CL:0002222 name: vertebrate lens cell +def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544] +xref: FMA:70950 is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye @@ -2851,16 +3693,19 @@ relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye [Term] id: CL:0002224 name: lens epithelial cell +def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544] +xref: FMA:67559 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002222 ! vertebrate lens cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:0001803 ! part of epithelium of lens relationship: BFO:0000050 UBERON:0001803 ! part of epithelium of lens -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002240 name: marrow fibroblast +def: "A fibroblast in the bone marrow." [GOC:tfm] +xref: FMA:84377 is_a: CL:0000057 ! fibroblast is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000057 ! fibroblast @@ -2869,6 +3714,8 @@ intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow [Term] id: CL:0002241 name: pulmonary interstitial fibroblast +def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm] +xref: FMA:84467 is_a: CL:0000057 ! fibroblast is_a: CL:4030031 ! interstitial cell intersection_of: CL:0000057 ! fibroblast @@ -2879,14 +3726,31 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: CL:0002242 name: nucleate cell +def: "A cell containing at least one nucleus." [GOC:tfm] +xref: FMA:67513 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0002505 ! bearer of relationship: RO:0000053 PATO:0002505 ! bearer of +[Term] +id: CL:0002243 +name: smooth muscle cell of sphincter of pupil +def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128] +xref: FMA:70611 +is_a: CL:0000358 ! sphincter associated smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: BFO:0000050 UBERON:0001607 ! part of sphincter pupillae +relationship: BFO:0000050 UBERON:0001607 ! part of sphincter pupillae +relationship: RO:0002202 CL:0000133 ! neurectodermal cell + [Term] id: CL:0002246 name: peripheral blood stem cell +def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm] +xref: BTO:0002669 +xref: FMA:86711 +xref: MESH:D000072916 is_a: CL:0000037 ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell intersection_of: CL:0000037 ! hematopoietic stem cell @@ -2896,6 +3760,7 @@ relationship: BFO:0000050 UBERON:0000178 ! part of blood [Term] id: CL:0002251 name: epithelial cell of alimentary canal +def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract @@ -2904,31 +3769,104 @@ relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: CL:0002252 name: epithelial cell of esophagus +def: "An epithelial cell of the esophagus." [GOC:tfm] +xref: FMA:63071 is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus +[Term] +id: CL:0002253 +name: epithelial cell of large intestine +def: "An epithelial cell of the large intestine." [GOC:tfm] +xref: BTO:0004297 +xref: FMA:256157 +is_a: CL:0002563 ! intestinal epithelial cell +intersection_of: CL:0002563 ! intestinal epithelial cell +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine + +[Term] +id: CL:0002254 +name: epithelial cell of small intestine +def: "An epithelial cell of the small intestine." [GOC:tfm] +xref: FMA:256159 +is_a: CL:0002563 ! intestinal epithelial cell +intersection_of: CL:0002563 ! intestinal epithelial cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0002108 ! part of small intestine + [Term] id: CL:0002262 name: endothelial cell of sinusoid +def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256] +xref: FMA:63134 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0003909 ! part of sinusoid relationship: BFO:0000050 UBERON:0003909 ! part of sinusoid -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002264 name: type A cell of stomach +def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm] +xref: FMA:83411 is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach +[Term] +id: CL:0002265 +name: type D cell of colon +def: "A D cell located in the colon." [GOC:tfm] +xref: FMA:268744 +is_a: CL:0000502 ! type D enteroendocrine cell +is_a: CL:0009042 ! enteroendocrine cell of colon +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:0002266 +name: type D cell of small intestine +def: "A type D cell of the small intestine." [GOC:tfm] +xref: FMA:268736 +is_a: CL:0000502 ! type D enteroendocrine cell +is_a: CL:0009006 ! enteroendocrine cell of small intestine +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: CL:0002267 +name: type D cell of stomach +def: "A type D cell found in the stomach." [GOC:tfm] +xref: FMA:83410 +is_a: CL:0000502 ! type D enteroendocrine cell +is_a: CL:0002659 ! glandular cell of stomach +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach + +[Term] +id: CL:0002275 +name: pancreatic PP cell +def: "A PP cell located in the islets of the pancreas." [GOC:tfm] +comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. +xref: BTO:0000805 +xref: FMA:70588 +xref: MESH:D050418 +is_a: CL:0000696 ! PP cell +is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0000696 ! PP cell +intersection_of: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans + [Term] id: CL:0002308 name: epithelial cell of skin gland +def: "An epithelial cell of a skin gland." [GOC:tfm] +xref: FMA:70657 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002419 ! part of skin gland @@ -2937,6 +3875,9 @@ relationship: BFO:0000050 UBERON:0002419 ! part of skin gland [Term] id: CL:0002319 name: neural cell +def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] +xref: CALOHA:TS-2040 +xref: FMA:70333 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system @@ -2945,6 +3886,10 @@ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system [Term] id: CL:0002320 name: connective tissue cell +def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256] +xref: CALOHA:TS-2096 +xref: FMA:63875 +xref: MESH:D003239 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue @@ -2953,11 +3898,17 @@ relationship: BFO:0000050 UBERON:0002384 ! part of connective tissue [Term] id: CL:0002321 name: embryonic cell (metazoa) +def: "A cell of the embryo." [FMA:0618947256] +xref: CALOHA:TS-0263 +xref: FMA:82840 +xref: WBbt:0007028 is_a: CL:0000000 ! cell [Term] id: CL:0002328 name: bronchial epithelial cell +def: "An epithelial cell of the bronchus." [GOC:tfm] +xref: BTO:0002922 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus @@ -2966,15 +3917,16 @@ relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus [Term] id: CL:0002332 name: ciliated cell of the bronchus +def: "A ciliated cell of the bronchus." [GOC:tfm, PMID:18757316] is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0000064 ! ciliated cell intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002333 name: neural crest derived adipocyte +def: "An adipocyte derived from a neural crest cell." [GOC:tfm, PMID:17507398] is_a: CL:0000136 ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell @@ -2984,15 +3936,23 @@ relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0002350 name: endocardial cell +def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458] +xref: FMA:75621 is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0002165 ! part of endocardium relationship: BFO:0000050 UBERON:0002165 ! part of endocardium -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0002351 +name: progenitor cell of endocrine pancreas +def: "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494, PMID:22728667] +is_a: CL:0011026 ! progenitor cell [Term] id: CL:0002352 name: gestational hematopoietic stem cell +def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6] is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -3001,15 +3961,17 @@ relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: CL:0002363 name: keratocyte +def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." [GOC:tfm, ISBN:9780702029585] is_a: CL:0000005 ! neural crest derived fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea relationship: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002368 name: respiratory epithelial cell +def: "An endo-epithelial cell of the respiratory tract." [GOC:tfm] +xref: BTO:0004533 is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium @@ -3018,6 +3980,7 @@ relationship: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium [Term] id: CL:0002372 name: myotube +def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000737 ! striated muscle cell intersection_of: CL:0000187 ! muscle cell @@ -3029,6 +3992,8 @@ relationship: RO:0000053 PATO:0002478 ! bearer of [Term] id: CL:0002397 name: CD14-positive, CD16-positive monocyte +def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [GOC:tfm, PMID:20628149, PMID:21937707, PMID:22343568] +comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+). is_a: CL:0001054 ! CD14-positive monocyte intersection_of: CL:0001054 ! CD14-positive monocyte intersection_of: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part @@ -3039,6 +4004,7 @@ relationship: RO:0002104 PR:000001483 [Term] id: CL:0002421 name: nucleated reticulocyte +def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052] is_a: CL:0000558 ! reticulocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000558 ! reticulocyte @@ -3047,6 +4013,7 @@ intersection_of: RO:0000053 PATO:0002505 ! bearer of [Term] id: CL:0002454 name: Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell +def: "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part @@ -3057,6 +4024,7 @@ relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part [Term] id: CL:0002462 name: adipose dendritic cell +def: "A F4/80-negative dendritic cell located in adipose tissue." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell is_a: CL:0002320 ! connective tissue cell @@ -3070,6 +4038,7 @@ relationship: RO:0002202 CL:0002010 ! pre-conventional dendritic cell [Term] id: CL:0002463 name: SIRPa-positive adipose dendritic cell +def: "An adipose dendritic cell that is SIRPa-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001968 @@ -3078,6 +4047,7 @@ relationship: RO:0002104 PR:000001968 [Term] id: CL:0002464 name: SIRPa-negative adipose dendritic cell +def: "An adipose dendritic cell that is SIRPa-negative." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: CL:4030046 PR:000001968 ! lacks_plasma_membrane_part @@ -3086,6 +4056,7 @@ relationship: CL:4030046 PR:000001968 ! lacks_plasma_membrane_part [Term] id: CL:0002465 name: CD11b-positive dendritic cell +def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001012 @@ -3094,6 +4065,12 @@ relationship: RO:0002104 PR:000001012 [Term] id: CL:0002494 name: cardiocyte +def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm] +comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. +xref: BTO:0001539 +xref: CALOHA:TS-0115 +xref: FMA:83808 +xref: FMA:84791 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ @@ -3102,24 +4079,47 @@ relationship: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ [Term] id: CL:0002503 name: adventitial cell +def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm] +xref: BTO:0002441 +xref: FMA:84639 is_a: CL:0000630 ! supporting cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: BFO:0000050 UBERON:0005742 ! part of adventitia relationship: BFO:0000050 UBERON:0005742 ! part of adventitia +[Term] +id: CL:0002504 +name: enteric smooth muscle cell +def: "A smooth muscle cell of the intestine." [GOC:tfm] +is_a: CL:0000192 ! smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0000160 ! part of intestine + [Term] id: CL:0002521 name: subcutaneous adipocyte +def: "An adipocyte that is part of subcutaneous adipose tissue." [GOC:tfm] is_a: CL:0000136 ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: BFO:0000050 UBERON:0002190 ! part of subcutaneous adipose tissue relationship: BFO:0000050 UBERON:0002190 ! part of subcutaneous adipose tissue -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0002538 +name: intrahepatic cholangiocyte +def: "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." [GOC:tfm, PMID:23720296] +is_a: CL:1000488 ! cholangiocyte +intersection_of: CL:1000488 ! cholangiocyte +intersection_of: BFO:0000050 UBERON:0004823 ! part of intrahepatic bile duct epithelium +relationship: BFO:0000050 UBERON:0004823 ! part of intrahepatic bile duct epithelium [Term] id: CL:0002539 name: aortic smooth muscle cell +def: "A smooth muscle cell of the aorta." [GOC:tfm] +xref: BTO:0004577 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0004178 ! part of aorta smooth muscle tissue @@ -3128,6 +4128,7 @@ relationship: BFO:0000050 UBERON:0004178 ! part of aorta smooth muscle tissue [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow +def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000134 ! mesenchymal stem cell @@ -3136,20 +4137,25 @@ intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow [Term] id: CL:0002543 name: vein endothelial cell +def: "An endothelial cell that is part of the vein." [GOC:tfm] +xref: FMA:62104 +xref: KUPO:0001099 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0001638 ! part of vein relationship: BFO:0000050 UBERON:0001638 ! part of vein -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002546 name: embryonic blood vessel endothelial progenitor cell +def: "An endothelial progenitor cell that participates in angiogenesis during development." [GOC:tfm] +comment: See CL:0002619. is_a: CL:0000222 ! mesodermal cell [Term] id: CL:0002547 name: fibroblast of the aortic adventitia +def: "A fibroblast of the aortic adventitia." [GOC:tfm] is_a: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia @@ -3158,6 +4164,7 @@ relationship: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia [Term] id: CL:0002548 name: fibroblast of cardiac tissue +def: "A fibroblast that is part of the heart." [GOC:tfm] is_a: CL:0000057 ! fibroblast is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000057 ! fibroblast @@ -3167,6 +4174,7 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: CL:0002551 name: fibroblast of dermis +def: "Any skin fibroblast that is part of some dermis." [FBC:Autogenerated] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis @@ -3175,6 +4183,9 @@ relationship: BFO:0000050 UBERON:0002067 ! part of dermis [Term] id: CL:0002553 name: fibroblast of lung +def: "A fibroblast that is part of lung." [GOC:tfm] +xref: BTO:0000764 +xref: CALOHA:TS-0575 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -3183,23 +4194,62 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: CL:0002557 name: fibroblast of pulmonary artery +def: "A fibroblast of pulmonary artery." [GOC:tfm] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0002563 +name: intestinal epithelial cell +def: "An epithelial cell of the intestine." [GOC:tfm] +is_a: CL:0002251 ! epithelial cell of alimentary canal +intersection_of: CL:0000066 ! epithelial cell +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium [Term] id: CL:0002570 name: mesenchymal stem cell of adipose tissue +def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0001013 ! part of adipose tissue relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue +[Term] +id: CL:0002571 +name: hepatic mesenchymal stem cell +def: "A mesenchymal stem cell of liver." [GOC:tfm] +is_a: CL:0000134 ! mesenchymal stem cell +is_a: CL:0002195 ! hepatic stem cell +intersection_of: CL:0000134 ! mesenchymal stem cell +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver + +[Term] +id: CL:0002572 +name: vertebral mesenchymal stem cell +def: "A mesenchymal stem cell of the vertebrae." [GOC:tfm] +is_a: CL:0000134 ! mesenchymal stem cell +is_a: CL:0001035 ! bone cell +intersection_of: CL:0000134 ! mesenchymal stem cell +intersection_of: BFO:0000050 UBERON:0002412 ! part of vertebra +relationship: BFO:0000050 UBERON:0002412 ! part of vertebra + +[Term] +id: CL:0002574 +name: stromal cell of pancreas +def: "A stromal cell of the pancreas." [GOC:tfm] +is_a: CL:0000499 ! stromal cell +intersection_of: CL:0000499 ! stromal cell +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: CL:0002575 name: central nervous system pericyte +def: "A pericyte of the central nervous system." [GOC:tfm] is_a: CL:0000669 ! pericyte is_a: CL:0002319 ! neural cell intersection_of: CL:0000669 ! pericyte @@ -3209,16 +4259,17 @@ relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system [Term] id: CL:0002585 name: retinal blood vessel endothelial cell +def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm] is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0000966 ! part of retina relationship: BFO:0000050 UBERON:0000966 ! part of retina -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002589 name: smooth muscle cell of the brachiocephalic vasculature +def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery @@ -3227,6 +4278,7 @@ relationship: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery [Term] id: CL:0002590 name: smooth muscle cell of the brain vasculature +def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm] is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell @@ -3236,15 +4288,17 @@ relationship: BFO:0000050 UBERON:0000955 ! part of brain [Term] id: CL:0002591 name: smooth muscle cell of the pulmonary artery +def: "A smooth muscle of the pulmonary artery." [GOC:tfm] +xref: BTO:0003336 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002595 name: smooth muscle cell of the subclavian artery +def: "A smooth muscle cell of the subclavian artery." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0001533 ! part of subclavian artery @@ -3253,6 +4307,7 @@ relationship: BFO:0000050 UBERON:0001533 ! part of subclavian artery [Term] id: CL:0002596 name: smooth muscle cell of the carotid artery +def: "Smooth muscle cell of the carotid artery." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0005396 ! part of carotid artery segment @@ -3261,15 +4316,17 @@ relationship: BFO:0000050 UBERON:0005396 ! part of carotid artery segment [Term] id: CL:0002598 name: bronchial smooth muscle cell +def: "Any smooth muscle cell that is part of some bronchus." [FBC:Autogenerated] +xref: BTO:0004402 is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002599 name: smooth muscle cell of the esophagus +def: "A smooth muscle cell of the esophagus." [GOC:tfm] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -3278,6 +4335,7 @@ relationship: BFO:0000050 UBERON:0001043 ! part of esophagus [Term] id: CL:0002600 name: smooth muscle cell of trachea +def: "A smooth muscle cell of the trachea." [GOC:tfm] is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea @@ -3286,6 +4344,7 @@ relationship: BFO:0000050 UBERON:0003126 ! part of trachea [Term] id: CL:0002610 name: raphe nuclei neuron +def: "A neuron of the raphe nuclei." [GOC:tfm] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) @@ -3295,6 +4354,7 @@ relationship: RO:0002100 UBERON:0004684 ! raphe nuclei [Term] id: CL:0002612 name: neuron of the ventral spinal cord +def: "A neuron of the ventral spinal cord." [GOC:tfm] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) @@ -3304,15 +4364,18 @@ relationship: RO:0002100 UBERON:0002257 ! ventral horn of spinal cord [Term] id: CL:0002620 name: skin fibroblast +def: "A fibroblast of skin." [GOC:tfm] +xref: BTO:0001255 +xref: CALOHA:TS-0935 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000050 UBERON:0002097 ! part of skin of body -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002632 name: epithelial cell of lower respiratory tract +def: "Any epithelial cell that is part of some lower respiratory tract epithelium." [FBC:Autogenerated] is_a: CL:0002368 ! respiratory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004815 ! part of lower respiratory tract epithelium @@ -3321,19 +4384,35 @@ relationship: BFO:0000050 UBERON:0004815 ! part of lower respiratory tract epith [Term] id: CL:0002653 name: squamous endothelial cell +def: "A squamous shaped endothelial cell." [GOC:dos] is_a: CL:0000115 ! endothelial cell [Term] id: CL:0002657 name: glandular cell of esophagus +def: "A glandular epithelial cell of the esophagus." [GOC:tfm] +xref: FMA:86548 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus +[Term] +id: CL:0002658 +name: glandular cell of the large intestine +def: "A glandular epithelial cell of the large intestine." [GOC:tfm] +xref: FMA:87194 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0002253 ! epithelial cell of large intestine +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine + [Term] id: CL:0002659 name: glandular cell of stomach +def: "A glandular epithelial cell that is part of the stomach." [GOC:tfm] +xref: CALOHA:TS-1284 +xref: FMA:86554 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000150 ! glandular epithelial cell @@ -3342,6 +4421,8 @@ intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: CL:0002663 name: myocardial endocrine cell of atrium +def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm] +xref: FMA:83389 is_a: CL:0002074 ! myocardial endocrine cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium @@ -3350,11 +4431,14 @@ relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium [Term] id: CL:0002664 name: cardioblast +def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164] +comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0002672 name: retinal progenitor cell +def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186] is_a: BFO:0000002 is_a: CL:0000048 ! multi fate stem cell relationship: RO:0002202 CL:0000133 ! neurectodermal cell @@ -3362,13 +4446,25 @@ relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0002676 name: neural crest derived neuroblast +def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019] is_a: CL:0000031 ! neuroblast (sensu Vertebrata) is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell +[Term] +id: CL:0002680 +name: PP cell of intestine +def: "A PP cell found in intestine." [GOC:tfm, PMID:2420136, PMID:728970] +is_a: CL:0000696 ! PP cell +is_a: CL:1001516 ! intestinal enteroendocrine cell +intersection_of: CL:0000696 ! PP cell +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine + [Term] id: CL:0005000 name: spinal cord interneuron +def: "A CNS interneuron located in the spinal cord." [CL:CVS] +comment: Is_a interneuron, part_of UBERON:0002240. is_a: CL:0000402 ! CNS interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002240 ! spinal cord @@ -3377,16 +4473,26 @@ relationship: RO:0002100 UBERON:0002240 ! spinal cord [Term] id: CL:0005012 name: multi-ciliated epithelial cell +def: "A ciliated epithelial cell with many cilia." [CL:CVS] is_a: CL:0000067 ! ciliated epithelial cell +[Term] +id: CL:0005026 +name: hepatoblast +def: "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." [GOC:CVS, https://orcid.org/0000-0003-1940-6740, PMID:18356246, PMID:20483998, PMID:26798363] +is_a: CL:0000048 ! multi fate stem cell + [Term] id: CL:0007001 name: skeletogenic cell +def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034] +comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) is_a: CL:0000000 ! cell [Term] id: CL:0007004 name: premigratory neural crest cell +def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002] is_a: BFO:0000002 is_a: CL:0011012 ! neural crest cell relationship: BFO:0000050 UBERON:0002342 ! part of neural crest @@ -3395,21 +4501,26 @@ relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0007009 name: prechondroblast +def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034] is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0008000 name: non-striated muscle cell +def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008001 name: hematopoietic precursor cell +def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos] is_a: CL:0000988 ! hematopoietic cell [Term] id: CL:0008002 name: skeletal muscle fiber +def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908] +xref: MESH:D018485 is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0002372 ! myotube intersection_of: CL:0000187 ! muscle cell @@ -3422,6 +4533,7 @@ relationship: RO:0002202 CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0008007 name: visceral muscle cell +def: "A muscle cell that is part of some visceral muscle." [GOC:dos] is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:8600004 ! part of visceral muscle tissue @@ -3430,6 +4542,7 @@ relationship: BFO:0000050 UBERON:8600004 ! part of visceral muscle tissue [Term] id: CL:0008008 name: striated visceral muscle cell +def: "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." [GOC:dos] is_a: CL:0000737 ! striated muscle cell is_a: CL:0008007 ! visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell @@ -3438,6 +4551,7 @@ intersection_of: RO:0000053 PATO:0001410 {all_some="true"} ! bearer of [Term] id: CL:0008009 name: transversely striated visceral muscle cell +def: "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." [GOC:dos] is_a: CL:0008008 ! striated visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: RO:0000053 PATO:0002478 {all_some="true"} ! bearer of @@ -3446,6 +4560,8 @@ relationship: RO:0000053 PATO:0002478 ! bearer of [Term] id: CL:0008017 name: adult skeletal muscle myoblast +def: "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [PMID:23303905] +comment: The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins. is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast @@ -3459,20 +4575,30 @@ def: "A non-polarised cell precursor cell that is part of some mesenchyme, is as is_a: CL:0000219 ! motile cell relationship: BFO:0000050 UBERON:0003104 ! part of mesenchyme relationship: RO:0002215 GO:0016477 ! capable of cell migration -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0008022 name: endocardial cushion cell +def: "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [PMID:18816864] is_a: CL:0000569 ! cardiac mesenchymal cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000569 ! cardiac mesenchymal cell intersection_of: BFO:0000050 UBERON:0002062 ! part of endocardial cushion relationship: BFO:0000050 UBERON:0002062 ! part of endocardial cushion +[Term] +id: CL:0008024 +name: pancreatic endocrine cell +def: "An endocrine cell that is part of the pancreas." [GOC:dos] +is_a: CL:0000083 ! epithelial cell of pancreas +is_a: CL:0000164 ! enteroendocrine cell +intersection_of: CL:0000163 ! endocrine cell +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: CL:0008028 name: visual system neuron +def: "Any neuron that is capable of part of some visual perception." [FBC:Autogenerated] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002216 GO:0007601 ! capable of part of visual perception @@ -3481,12 +4607,13 @@ relationship: RO:0002216 GO:0007601 ! capable of part of visual perception [Term] id: CL:0008034 name: mural cell +def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." [Wiki:Mural_cell&oldid=930603194] is_a: CL:4033054 ! perivascular cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0008035 name: microcirculation associated smooth muscle cell +def: "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel." [FBC:Autogenerated] is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:0008034 ! mural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell @@ -3496,6 +4623,7 @@ relationship: BFO:0000050 UBERON:0010523 ! part of microcirculatory vessel [Term] id: CL:0009000 name: sensory neuron of spinal nerve +def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr] is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: RO:0002100 UBERON:0001780 ! spinal nerve @@ -3505,33 +4633,200 @@ relationship: RO:0002100 UBERON:0001780 ! spinal nerve id: CL:0009001 name: compound eye retinal cell def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." [] +xref: GOC:pr +xref: PMID:12021768 is_a: CL:0009004 ! retinal cell [Term] id: CL:0009004 name: retinal cell +def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:pr] +xref: PMID:10702418 is_a: CL:0002319 ! neural cell intersection_of: CL:0002319 ! neural cell intersection_of: BFO:0000050 UBERON:0005388 ! part of photoreceptor array relationship: BFO:0000050 UBERON:0005388 ! part of photoreceptor array +[Term] +id: CL:0009006 +name: enteroendocrine cell of small intestine +def: "An enteroendocrine cell that is located in the small intestine." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:1001516 ! intestinal enteroendocrine cell +is_a: CL:1001598 ! small intestine glandular cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: CL:0009018 +name: lymphocyte of large intestine lamina propria +def: "A lymphocyte that resides in the lamina propria of the large intestine." [https://orcid.org/0000-0003-4183-8865] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +is_a: CL:0000542 ! lymphocyte +intersection_of: CL:0000542 ! lymphocyte +intersection_of: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine +relationship: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine + +[Term] +id: CL:0009021 +name: stromal cell of lamina propria of large intestine +def: "A stromal cell found in the lamina propria of the large intestine." [http://orcid.org/0000-0003-4183-8865] +is_a: CL:0000499 ! stromal cell +intersection_of: CL:0000499 ! stromal cell +intersection_of: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine +relationship: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine + +[Term] +id: CL:0009022 +name: stromal cell of lamina propria of small intestine +def: "A stromal cell found in the lamina propria of the small intestine." [http://orcid.org/0000-0003-4183-8865] +is_a: CL:0000499 ! stromal cell +intersection_of: CL:0000499 ! stromal cell +intersection_of: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine +relationship: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine + +[Term] +id: CL:0009024 +name: mesothelial cell of small intestine +def: "A mesothelial cell that is part of the small intestine." [http://orcid.org/0000-0003-4183-8865] +is_a: CL:0000077 ! mesothelial cell +is_a: CL:0002254 ! epithelial cell of small intestine +intersection_of: CL:0000077 ! mesothelial cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: CL:0009025 +name: mesothelial cell of colon +def: "A mesothelial cell that is part of the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] +is_a: CL:0000077 ! mesothelial cell +is_a: CL:0011108 ! colon epithelial cell +intersection_of: CL:0000077 ! mesothelial cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:0009038 +name: colon macrophage +def: "A macrophage that is located in the colon." [http://orcid.org/0000-0003-3440-1876] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +is_a: CL:0000235 ! macrophage +intersection_of: CL:0000235 ! macrophage +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:0009040 +name: stromal cell of lamina propria of colon +def: "A stromal cell found in the lamina propria of the colon." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:0009021 ! stromal cell of lamina propria of large intestine +intersection_of: CL:0000499 ! stromal cell +intersection_of: BFO:0000050 UBERON:0007177 ! part of lamina propria of mucosa of colon +relationship: BFO:0000050 UBERON:0007177 ! part of lamina propria of mucosa of colon + +[Term] +id: CL:0009042 +name: enteroendocrine cell of colon +def: "An enteroendocrine cell that is located in the colon." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:1001516 ! intestinal enteroendocrine cell +is_a: CL:1001588 ! colon glandular cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:0009044 +name: lymphocyte of small intestine lamina propria +def: "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response." [https://orcid.org/0000-0003-4183-8865, PMID:26551552] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +is_a: CL:0000542 ! lymphocyte +intersection_of: CL:0000542 ! lymphocyte +intersection_of: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine +relationship: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine + +[Term] +id: CL:0009048 +name: anorectum macrophage +def: "A macrophage that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +is_a: CL:0000235 ! macrophage +intersection_of: CL:0000235 ! macrophage +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: CL:0009051 +name: T cell of anorectum +def: "A T cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +is_a: CL:0000084 ! T cell +intersection_of: CL:0000084 ! T cell +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: CL:0009052 +name: smooth muscle cell of anorectum +def: "A smooth muscle cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:1000279 ! smooth muscle cell of large intestine +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: CL:0009053 +name: stromal cell of anorectum lamina propria +def: "A stromal cell found in the lamina propria of the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:0009021 ! stromal cell of lamina propria of large intestine +intersection_of: CL:0000499 ! stromal cell +intersection_of: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: CL:0009063 +name: enteroendocrine cell of anorectum +def: "An enteroendocrine cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:0002658 ! glandular cell of the large intestine +is_a: CL:1001516 ! intestinal enteroendocrine cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + [Term] id: CL:0009089 name: lung pericyte +def: "A pericyte cell that is part of a lung." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] +xref: EFO:0010669 is_a: CL:0000669 ! pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0009094 +name: endothelial cell of hepatic portal vein +def: "An endothelial cell that is part of a hepatic portal vein." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865, PMID:30348985] +xref: EFO:0010704 +is_a: CL:0002543 ! vein endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: BFO:0000050 UBERON:0001639 ! part of hepatic portal vein +relationship: BFO:0000050 UBERON:0001639 ! part of hepatic portal vein [Term] id: CL:0009097 name: embryonic skeletal muscle fiber +def: "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." [http://orcid.org/0000-0003-2034-601X, PMID:32094117, PMID:7196501] is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: RO:0002491 UBERON:0000068 ! embryo stage relationship: RO:0002491 UBERON:0000068 ! embryo stage +[Term] +id: CL:0009100 +name: hepatic portal fibroblast +def: "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." [https://orcid.org/0000-0001-7655-4833, PMID:20209607, PMID:24814904] +is_a: CL:0000057 ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: BFO:0000050 UBERON:0001279 ! part of portal triad +relationship: BFO:0000050 UBERON:0001279 ! part of portal triad + [Term] id: CL:0010001 name: stromal cell of bone marrow @@ -3545,6 +4840,8 @@ intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow id: CL:0010003 name: epithelial cell of alveolus of lung def: "An epithelial cell that is part_of a alveolus of lung." [] +comment: May be merged with pneumocyte in future +xref: MESH:D056809 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002299 ! part of alveolus of lung @@ -3562,6 +4859,7 @@ intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow [Term] id: CL:0010006 name: cardiac blood vessel endothelial cell +def: "Any blood vessel endothelial cell that is part of some heart." [FBC:Autogenerated] is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell @@ -3570,6 +4868,7 @@ intersection_of: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: CL:0010007 name: His-Purkinje system cell +def: "Any cell that is part of some His-Purkinje system." [FBC:Autogenerated] is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system @@ -3578,16 +4877,17 @@ relationship: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system [Term] id: CL:0010008 name: cardiac endothelial cell +def: "Any endothelial cell that is part of some heart." [FBC:Autogenerated] is_a: CL:0000115 ! endothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0010009 name: camera-type eye photoreceptor cell +def: "Any photoreceptor cell that is part of some camera-type eye." [FBC:Autogenerated] is_a: BFO:0000002 is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0009004 ! retinal cell @@ -3599,11 +4899,13 @@ relationship: BFO:0000050 UBERON:0000966 ! part of retina id: CL:0010017 name: zygote def: "A zygote in a plant or an animal." [] +xref: MESH:D015053 is_a: CL:0000000 ! cell [Term] id: CL:0010020 name: cardiac glial cell +def: "Any glial cell that is part of some heart." [FBC:Autogenerated] is_a: CL:0000125 ! glial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000125 ! glial cell @@ -3613,6 +4915,8 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: CL:0010021 name: cardiac myoblast +def: "Any myoblast that develops into some cardiac muscle cell." [FBC:Autogenerated] +xref: MESH:D032386 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000746 ! cardiac muscle cell @@ -3621,6 +4925,8 @@ relationship: RO:0002203 CL:0000746 ! cardiac muscle cell [Term] id: CL:0010022 name: cardiac neuron +def: "A neuron that has its soma in the heart." [PMID:12486170, PMID:29265764] +comment: This term is used in 3 GO terms that were created as part of the heart development focus project. is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000948 ! heart @@ -3629,6 +4935,7 @@ relationship: RO:0002100 UBERON:0000948 ! heart [Term] id: CL:0011001 name: spinal cord motor neuron +def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv] is_a: CL:0000100 ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron @@ -3638,6 +4945,7 @@ relationship: RO:0002100 UBERON:0002240 ! spinal cord [Term] id: CL:0011007 name: paraxial cell +def: "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." [GOC:NV, PMID:11687492] is_a: CL:0000222 ! mesodermal cell intersection_of: CL:0000222 ! mesodermal cell intersection_of: BFO:0000050 UBERON:0003059 ! part of presomitic mesoderm @@ -3646,6 +4954,7 @@ relationship: BFO:0000050 UBERON:0003059 ! part of presomitic mesoderm [Term] id: CL:0011012 name: neural crest cell +def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0002-9900-7880] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002321 ! embryonic cell (metazoa) @@ -3680,6 +4989,7 @@ relationship: BFO:0000050 UBERON:0001068 ! part of skin of back [Term] id: CL:0011026 name: progenitor cell +def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3] is_a: BFO:0000002 is_a: CL:0011115 ! precursor cell intersection_of: CL:0011115 ! precursor cell @@ -3689,6 +4999,7 @@ relationship: RO:0002202 CL:0000034 ! stem cell [Term] id: CL:0011027 name: skeletal muscle fibroblast +def: "Any fibroblast that is part of skeletal muscle tissue." [https://orcid.org/0000-0001-6164-0667, PMID:28369879] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:1001609 ! muscle fibroblast intersection_of: CL:0000057 ! fibroblast @@ -3697,14 +5008,26 @@ intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue [Term] id: CL:0011030 name: dermal microvascular endothelial cell +def: "Any microvascular endothelial cell that is part of the dermis." [BTO:0004574, CL:patterns/cellPartOfAnatomicalEntity] is_a: CL:2000008 ! microvascular endothelial cell is_a: CL:2000010 ! dermis blood vessel endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis +[Term] +id: CL:0011108 +name: colon epithelial cell +def: "Epithelial cell that is part of the colon epithelium." [GOC:NV] +is_a: CL:0002253 ! epithelial cell of large intestine +intersection_of: CL:0000066 ! epithelial cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0000397 ! part of colonic epithelium + [Term] id: CL:0011115 name: precursor cell +def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos] +comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0030154 ! capable of cell differentiation @@ -3713,6 +5036,7 @@ relationship: RO:0002215 GO:0030154 ! capable of cell differentiation [Term] id: CL:0017500 name: neutrophillic cytoplasm +def: "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." [GOC:add] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0070046 ! bearer of @@ -3721,6 +5045,7 @@ relationship: RO:0000053 PATO:0070046 ! bearer of [Term] id: CL:0017502 name: acidophilic cytoplasm +def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." [GOC:add] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0002418 ! bearer of @@ -3729,6 +5054,7 @@ relationship: RO:0000053 PATO:0002418 ! bearer of [Term] id: CL:0017503 name: basophilic cytoplasm +def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0002094 ! bearer of @@ -3737,6 +5063,7 @@ relationship: RO:0000053 PATO:0002094 ! bearer of [Term] id: CL:0017504 name: polychromatophilic cytoplasm +def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0070047 ! bearer of @@ -3759,29 +5086,58 @@ is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0019018 name: blood vessel smooth muscle cell +def: "A smooth muscle cell that is part of any blood vessel." [PMID:9108778] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0019019 name: tracheobronchial smooth muscle cell +def: "A smooth muscle cell that is part of the tracheobronchial tree." [PMID:10853867] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0019020 +name: extrahepatic cholangiocyte +def: "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." [PMID:23720296] +is_a: CL:1000488 ! cholangiocyte +intersection_of: CL:1000488 ! cholangiocyte +intersection_of: BFO:0000050 UBERON:0004822 ! part of extrahepatic bile duct epithelium +relationship: BFO:0000050 UBERON:0004822 ! part of extrahepatic bile duct epithelium + +[Term] +id: CL:0019021 +name: endothelial cell of periportal hepatic sinusoid +def: "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." [PMID:27423426] +xref: EFO:0010705 +is_a: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: RO:0002220 UBERON:0001279 ! adjacent to portal triad +relationship: RO:0002220 UBERON:0001279 ! adjacent to portal triad + +[Term] +id: CL:0019022 +name: endothelial cell of pericentral hepatic sinusoid +def: "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." [PMID:27423426] +xref: EFO:0010706 +is_a: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: RO:0002220 UBERON:0006841 ! adjacent to central vein of liver +relationship: RO:0002220 UBERON:0006841 ! adjacent to central vein of liver [Term] id: CL:1000222 name: stomach neuroendocrine cell +def: "Any neuroendocrine cell that is part of some stomach." [FBC:Autogenerated] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0002659 ! glandular cell of stomach @@ -3791,6 +5147,7 @@ intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: CL:1000223 name: lung neuroendocrine cell +def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [doi:10.3109/01902148209069653, doi:10.7554/eLife.78216, PMID:33355253] is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000165 ! neuroendocrine cell @@ -3801,20 +5158,20 @@ intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000051 GO:0031045 ! has part dense core granule relationship: RO:0002215 GO:0070483 ! capable of detection of hypoxia -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000271 name: lung ciliated cell +def: "Any ciliated cell that is part of some lung." [FBC:Autogenerated] is_a: CL:4030034 ! respiratory ciliated cell intersection_of: CL:0000064 ! ciliated cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000272 name: lung secretory cell +def: "Any secretory cell that is part of some lung." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -3825,9 +5182,71 @@ id: CL:1000274 name: trophectodermal cell is_a: CL:0000349 ! extraembryonic cell +[Term] +id: CL:1000275 +name: smooth muscle cell of small intestine +def: "A smooth muscle cell that is part of the small intestine." [GOC:tfm] +xref: FMA:15050 +is_a: CL:0002504 ! enteric smooth muscle cell +intersection_of: CL:0002504 ! enteric smooth muscle cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: CL:1000276 +name: smooth muscle fiber of duodenum +def: "A smooth muscle cell that is part of the duodenum." [GOC:tfm] +xref: FMA:15058 +is_a: CL:1000275 ! smooth muscle cell of small intestine +intersection_of: CL:1000275 ! smooth muscle cell of small intestine +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + +[Term] +id: CL:1000279 +name: smooth muscle cell of large intestine +def: "A smooth muscle cell that is part of the large intestine." [GOC:tfm] +xref: FMA:15653 +is_a: CL:0002504 ! enteric smooth muscle cell +intersection_of: CL:0002504 ! enteric smooth muscle cell +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine + +[Term] +id: CL:1000280 +name: smooth muscle cell of colon +def: "A smooth muscle cell that is part of the colon." [GOC:tfm] +xref: FMA:15663 +is_a: CL:1000279 ! smooth muscle cell of large intestine +intersection_of: CL:0002504 ! enteric smooth muscle cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:1000285 +name: smooth muscle cell of sigmoid colon +def: "A smooth muscle cell that is part of the sigmoid colon." [GOC:tfm] +xref: FMA:17521 +is_a: CL:1000280 ! smooth muscle cell of colon +intersection_of: CL:1000280 ! smooth muscle cell of colon +intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon +relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon + +[Term] +id: CL:1000286 +name: smooth muscle cell of rectum +def: "A smooth muscle cell that is part of the rectum." [GOC:tfm] +xref: FMA:17522 +is_a: CL:1000279 ! smooth muscle cell of large intestine +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + [Term] id: CL:1000303 name: fibroblast of areolar connective tissue +def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm] +xref: FMA:261279 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0006815 ! part of areolar connective tissue @@ -3836,6 +5255,8 @@ relationship: BFO:0000050 UBERON:0006815 ! part of areolar connective tissue [Term] id: CL:1000306 name: fibroblast of tunica adventitia of artery +def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm] +xref: FMA:261285 is_a: CL:0000057 ! fibroblast is_a: CL:0002503 ! adventitial cell intersection_of: CL:0000057 ! fibroblast @@ -3845,6 +5266,8 @@ relationship: BFO:0000050 UBERON:0005734 ! part of tunica adventitia of blood ve [Term] id: CL:1000307 name: fibroblast of dense regular elastic tissue +def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm] +xref: FMA:261287 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0007846 ! part of dense regular connective tissue @@ -3854,14 +5277,17 @@ relationship: BFO:0000050 UBERON:0007846 ! part of dense regular connective tiss [Term] id: CL:1000309 name: epicardial adipocyte +def: "An adipocyte that is part of the epicardial fat." [GOC:tfm] +xref: FMA:261293 is_a: CL:0000136 ! adipocyte is_a: CL:0002494 ! cardiocyte relationship: BFO:0000050 UBERON:0002348 ! part of epicardium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000310 name: adipocyte of epicardial fat of right ventricle +def: "An adipocyte that is part of the epicardial fat of right ventricle." [GOC:tfm] +xref: FMA:261297 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle @@ -3870,6 +5296,8 @@ relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle [Term] id: CL:1000311 name: adipocyte of epicardial fat of left ventricle +def: "An adipocyte that is part of the epicardial fat of left ventricle." [GOC:tfm] +xref: FMA:261300 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle @@ -3878,24 +5306,28 @@ relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle [Term] id: CL:1000330 name: serous cell of epithelium of trachea +def: "A serous secreting cell that is part of the epithelium of trachea." [GOC:tfm] +xref: FMA:263078 is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea relationship: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000331 name: serous cell of epithelium of bronchus +def: "A serous secreting cell that is part of the epithelium of bronchus." [GOC:tfm] +xref: FMA:263080 is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000332 name: serous cell of epithelium of terminal bronchiole +def: "A serous secreting cell that is part of the epithelium of terminal bronchiole." [GOC:tfm] +xref: FMA:263082 is_a: CL:0019001 ! tracheobronchial serous cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000313 ! serous secreting cell @@ -3905,6 +5337,8 @@ relationship: BFO:0000050 UBERON:0001958 ! part of terminal bronchiole epitheliu [Term] id: CL:1000361 name: transitional myocyte of interatrial septum +def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm] +xref: FMA:263152 is_a: CL:0002073 ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte @@ -3914,6 +5348,8 @@ relationship: BFO:0000050 UBERON:0002085 ! part of interatrial septum [Term] id: CL:1000362 name: transitional myocyte of interventricular septum +def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm] +xref: FMA:263154 is_a: CL:0002073 ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte @@ -3923,15 +5359,31 @@ relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum [Term] id: CL:1000376 name: Purkinje myocyte of interventricular septum +def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm] +xref: FMA:263182 is_a: CL:0002068 ! Purkinje myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum +[Term] +id: CL:1000398 +name: endothelial cell of hepatic sinusoid +def: "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." [GOC:tfm, PMID:3926620] +xref: BTO:000125 +xref: FMA:62911 +is_a: CL:0000666 ! fenestrated endothelial cell +is_a: CL:0002262 ! endothelial cell of sinusoid +intersection_of: CL:0000115 ! endothelial cell +intersection_of: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid +relationship: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid + [Term] id: CL:1000409 name: myocyte of sinoatrial node +def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm] +xref: FMA:67102 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell intersection_of: CL:0000187 ! muscle cell @@ -3941,6 +5393,8 @@ relationship: BFO:0000050 UBERON:0002351 ! part of sinoatrial node [Term] id: CL:1000410 name: myocyte of atrioventricular node +def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm] +xref: FMA:67106 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell is_a: CL:2000022 ! cardiac septum cell @@ -3951,33 +5405,51 @@ relationship: BFO:0000050 UBERON:0002352 ! part of atrioventricular node [Term] id: CL:1000412 name: endothelial cell of arteriole +def: "An endothelial cell that is part of the arteriole." [GOC:tfm] +xref: FMA:67760 +xref: KUPO:0001097 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001980 ! part of arteriole relationship: BFO:0000050 UBERON:0001980 ! part of arteriole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000413 name: endothelial cell of artery +def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm] +xref: BTO:0004758 +xref: FMA:67761 +xref: KUPO:0001095 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0001917 ! part of endothelium of artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000414 name: endothelial cell of venule +def: "An endothelial cell that is part of the venule." [GOC:tfm] +xref: FMA:67762 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0001979 ! part of venule relationship: BFO:0000050 UBERON:0001979 ! part of venule -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:1000415 +name: epithelial cell of gallbladder +def: "An epithelial cell that is part of the gallbladder." [GOC:tfm] +xref: FMA:67780 +is_a: CL:0000066 ! epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder [Term] id: CL:1000428 name: stem cell of epidermis +def: "A somatic stem cell that is part of the epidermis." [GOC:tfm] +xref: FMA:70541 is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis @@ -3986,6 +5458,8 @@ relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis [Term] id: CL:1000443 name: ciliary muscle cell +def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm] +xref: FMA:70610 is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001775 ! part of ciliary body @@ -3994,6 +5468,8 @@ relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body [Term] id: CL:1000444 name: mesothelial cell of anterior chamber of eye +def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm] +xref: FMA:70615 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball @@ -4002,6 +5478,8 @@ relationship: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball [Term] id: CL:1000456 name: mesothelial cell of parietal peritoneum +def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm] +xref: FMA:72142 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001366 ! part of parietal peritoneum @@ -4010,15 +5488,18 @@ relationship: BFO:0000050 UBERON:0001366 ! part of parietal peritoneum [Term] id: CL:1000457 name: mesothelial cell of visceral peritoneum +def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm] +xref: FMA:72143 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum relationship: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000478 name: transitional myocyte of sinoatrial node +def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm] +xref: FMA:83384 is_a: CL:0002073 ! transitional myocyte is_a: CL:1000409 ! myocyte of sinoatrial node intersection_of: CL:0002073 ! transitional myocyte @@ -4027,6 +5508,8 @@ intersection_of: BFO:0000050 UBERON:0002351 ! part of sinoatrial node [Term] id: CL:1000479 name: Purkinje myocyte of atrioventricular node +def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm] +xref: FMA:83386 is_a: CL:0002068 ! Purkinje myocyte is_a: CL:1000410 ! myocyte of atrioventricular node intersection_of: CL:0002068 ! Purkinje myocyte @@ -4035,15 +5518,32 @@ intersection_of: BFO:0000050 UBERON:0002352 ! part of atrioventricular node [Term] id: CL:1000482 name: myocardial endocrine cell of interventricular septum +def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm] +xref: FMA:83390 is_a: CL:0002074 ! myocardial endocrine cell is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum +[Term] +id: CL:1000488 +name: cholangiocyte +def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246] +xref: FMA:86481 +is_a: BFO:0000002 +is_a: CL:0000069 ! branched duct epithelial cell +intersection_of: CL:0000069 ! branched duct epithelial cell +intersection_of: BFO:0000050 UBERON:0002394 ! part of bile duct +intersection_of: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity +relationship: BFO:0000050 UBERON:0002394 ! part of bile duct +relationship: RO:0002202 CL:0005026 ! hepatoblast + [Term] id: CL:1000490 name: mesothelial cell of peritoneum +def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm] +xref: FMA:86736 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum @@ -4052,6 +5552,8 @@ relationship: BFO:0000050 UBERON:0002358 ! part of peritoneum [Term] id: CL:1000491 name: mesothelial cell of pleura +def: "A mesothelial cell that is part of the pleura." [GOC:tfm] +xref: FMA:86737 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0000977 ! part of pleura @@ -4060,6 +5562,8 @@ relationship: BFO:0000050 UBERON:0000977 ! part of pleura [Term] id: CL:1000492 name: mesothelial cell of parietal pleura +def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm] +xref: FMA:86738 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002400 ! part of parietal pleura @@ -4068,15 +5572,36 @@ relationship: BFO:0000050 UBERON:0002400 ! part of parietal pleura [Term] id: CL:1000493 name: mesothelial cell of visceral pleura +def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm] +xref: FMA:86739 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002401 ! part of visceral pleura relationship: BFO:0000050 UBERON:0002401 ! part of visceral pleura -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:1001433 +name: epithelial cell of exocrine pancreas +def: "An epithelial cell of the exocrine pancreas." [GOC:tfm] +xref: FMA:70986 +is_a: CL:0000083 ! epithelial cell of pancreas +intersection_of: CL:0000066 ! epithelial cell +intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas + +[Term] +id: CL:1001516 +name: intestinal enteroendocrine cell +def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." [MP:0010802] +is_a: CL:0000164 ! enteroendocrine cell +is_a: CL:0002563 ! intestinal epithelial cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa [Term] id: CL:1001567 name: lung endothelial cell +def: "Any endothelial cell of vascular tree that is part of some lung." [FBC:Autogenerated] is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -4085,24 +5610,105 @@ relationship: BFO:0000050 UBERON:0000102 ! part of lung vasculature [Term] id: CL:1001568 name: pulmonary artery endothelial cell +def: "Any endothelial cell of vascular tree that is part of some pulmonary artery." [FBC:Autogenerated] +xref: BTO:0001141 is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0005317 ! part of pulmonary artery endothelium -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:1001572 +name: colon endothelial cell +def: "A vascular endothelial cell found in colon blood vessels." [https://orcid.org/0000-0001-5208-3432, NPX:PDR] +xref: CALOHA:TS-2397 +is_a: CL:0000115 ! endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0013695 ! part of colon endothelium [Term] id: CL:1001576 name: oral mucosa squamous cell +def: "Squamous cell of oral epithelium." [NPX:PDR] +xref: CALOHA:TS-1252 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0002424 ! part of oral epithelium relationship: BFO:0000050 UBERON:0002424 ! part of oral epithelium +[Term] +id: CL:1001588 +name: colon glandular cell +def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] +xref: CALOHA:TS-1274 +is_a: CL:0002658 ! glandular cell of the large intestine +is_a: CL:0011108 ! colon epithelial cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:1001589 +name: duodenum glandular cell +def: "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." [NPX:PDR] +xref: CALOHA:TS-1275 +is_a: CL:1001598 ! small intestine glandular cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0008346 ! part of duodenal epithelium + +[Term] +id: CL:1001592 +name: gallbladder glandular cell +def: "Glandular cell of gallbladder epithelium." [NPX:PDR] +xref: CALOHA:TS-1278 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:1000415 ! epithelial cell of gallbladder +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002029 ! part of epithelium of gall bladder + +[Term] +id: CL:1001595 +name: rectum glandular cell +def: "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] +xref: CALOHA:TS-1281 +is_a: CL:0002658 ! glandular cell of the large intestine +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0003354 ! part of epithelium of rectum + +[Term] +id: CL:1001598 +name: small intestine glandular cell +def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." [NCI_Thesaurus:Small_Intestinal_Glandular_Cell, NPX:PDR] +xref: CALOHA:TS-1286 +xref: FMA:86928 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0002254 ! epithelial cell of small intestine +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine + +[Term] +id: CL:1001599 +name: pancreas exocrine glandular cell +def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." [HPA:HPA, NPX:PDR] +xref: BTO:0000028 +xref: CALOHA:TS-1242 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0000152 ! exocrine cell +is_a: CL:1001433 ! epithelial cell of exocrine pancreas +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000050 UBERON:0013697 ! part of exocrine pancreas epithelium + [Term] id: CL:1001603 name: lung macrophage +def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." [HPA:HPA, NPX:PDR] +xref: CALOHA:TS-0576 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -4111,6 +5717,8 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: CL:1001609 name: muscle fibroblast +def: "Fibroblast from muscle organ." [NPX:PDR] +xref: CALOHA:TS-0643 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001630 ! part of muscle organ @@ -4119,6 +5727,8 @@ relationship: BFO:0000050 UBERON:0001630 ! part of muscle organ [Term] id: CL:1001610 name: bone marrow hematopoietic cell +def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR] +xref: CALOHA:TS-2109 is_a: CL:0000988 ! hematopoietic cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000988 ! hematopoietic cell @@ -4128,6 +5738,7 @@ relationship: BFO:0000050 UBERON:0012429 ! part of hematopoietic tissue [Term] id: CL:2000001 name: peripheral blood mononuclear cell +def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [GOC:TermGenie] is_a: CL:0000080 ! circulating cell is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000842 ! mononuclear cell @@ -4137,6 +5748,7 @@ relationship: BFO:0000050 UBERON:0000178 ! part of blood [Term] id: CL:2000008 name: microvascular endothelial cell +def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium @@ -4145,6 +5757,7 @@ relationship: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium [Term] id: CL:2000010 name: dermis blood vessel endothelial cell +def: "Any blood vessel endothelial cell that is part of a dermis." [GOC:TermGenie] is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis @@ -4153,6 +5766,7 @@ relationship: BFO:0000050 UBERON:0002067 ! part of dermis [Term] id: CL:2000013 name: fibroblast of skin of abdomen +def: "Any skin fibroblast that is part of a skin of abdomen." [GOC:TermGenie] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0001416 ! part of skin of abdomen @@ -4161,6 +5775,7 @@ relationship: BFO:0000050 UBERON:0001416 ! part of skin of abdomen [Term] id: CL:2000016 name: lung microvascular endothelial cell +def: "Any lung endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] is_a: CL:1001567 ! lung endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:1001567 ! lung endothelial cell @@ -4169,6 +5784,7 @@ intersection_of: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium [Term] id: CL:2000019 name: compound eye photoreceptor cell +def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie] is_a: CL:0000287 ! eye photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000018 ! part of compound eye @@ -4177,6 +5793,7 @@ relationship: BFO:0000050 UBERON:0000018 ! part of compound eye [Term] id: CL:2000020 name: inner cell mass cell +def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000087 ! part of inner cell mass @@ -4185,6 +5802,7 @@ relationship: BFO:0000050 UBERON:0000087 ! part of inner cell mass [Term] id: CL:2000022 name: cardiac septum cell +def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie] is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002099 ! part of cardiac septum @@ -4193,6 +5811,7 @@ relationship: BFO:0000050 UBERON:0002099 ! part of cardiac septum [Term] id: CL:2000029 name: central nervous system neuron +def: "Any neuron that is part of a central nervous system." [GOC:TermGenie] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001017 ! central nervous system @@ -4201,15 +5820,17 @@ relationship: RO:0002100 UBERON:0001017 ! central nervous system [Term] id: CL:2000032 name: peripheral nervous system neuron +def: "A neuron that is part of a peripheral nervous system." [GOC:TermGenie, ISBN:0721662544] +xref: FMA:84664 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000010 ! peripheral nervous system relationship: RO:0002100 UBERON:0000010 ! peripheral nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:2000042 name: embryonic fibroblast +def: "Any fibroblast that is part of a embryo." [GOC:TermGenie] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -4218,6 +5839,7 @@ relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: CL:2000043 name: brain pericyte +def: "Any pericyte cell that is part of a brain." [GOC:TermGenie] is_a: CL:0002575 ! central nervous system pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0000955 ! part of brain @@ -4226,6 +5848,7 @@ relationship: BFO:0000050 UBERON:0000955 ! part of brain [Term] id: CL:2000044 name: brain microvascular endothelial cell +def: "Any microvascular endothelial cell that is part of a brain." [GOC:TermGenie] is_a: CL:0002319 ! neural cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell @@ -4235,6 +5858,7 @@ relationship: BFO:0000050 UBERON:0000955 ! part of brain [Term] id: CL:2000046 name: ventricular cardiac muscle cell +def: "Any cardiac muscle cell that is part of a cardiac ventricle." [GOC:TermGenie] is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -4243,15 +5867,47 @@ relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle [Term] id: CL:2000047 name: brainstem motor neuron +def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie] is_a: CL:0000100 ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002100 UBERON:0002298 ! brainstem relationship: RO:0002100 UBERON:0002298 ! brainstem +[Term] +id: CL:2000051 +name: splenic fibroblast +def: "Any fibroblast that is part of a spleen." [GOC:TermGenie] +is_a: CL:0000057 ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + +[Term] +id: CL:2000053 +name: splenic endothelial cell +def: "Any endothelial cell that is part of a spleen." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5500 +is_a: CL:0000115 ! endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + +[Term] +id: CL:2000055 +name: liver dendritic cell +def: "Any dendritic cell that is part of a liver." [GOC:TermGenie] +comment: http://www.jleukbio.org/content/66/2/322.abstract +is_a: CL:0000451 ! dendritic cell +intersection_of: CL:0000451 ! dendritic cell +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: CL:2000063 name: ovarian fibroblast +def: "Any fibroblast that is part of a female gonad." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7330 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary @@ -4260,6 +5916,8 @@ relationship: BFO:0000050 UBERON:0000992 ! part of ovary [Term] id: CL:2000064 name: ovarian surface epithelial cell +def: "Any epithelial cell that is part of a female gonad." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7310 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary @@ -4268,32 +5926,48 @@ relationship: BFO:0000050 UBERON:0000992 ! part of ovary [Term] id: CL:2000066 name: cardiac ventricle fibroblast +def: "Any fibroblast that is part of a cardiac ventricle." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6310 is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:2000067 name: cardiac atrium fibroblast +def: "Any fibroblast that is part of a cardiac atrium." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6320 is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:2000068 name: pericardium fibroblast +def: "Any fibroblast that is part of a pericardium." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6430 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002407 ! part of pericardium relationship: BFO:0000050 UBERON:0002407 ! part of pericardium +[Term] +id: CL:2000069 +name: gallbladder fibroblast +def: "Any fibroblast that is part of a gallbladder." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5430 +is_a: CL:0000057 ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder + [Term] id: CL:2000070 name: optic choroid fibroblast +def: "Any fibroblast that is part of a optic choroid." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6620 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001776 ! part of optic choroid @@ -4302,6 +5976,8 @@ relationship: BFO:0000050 UBERON:0001776 ! part of optic choroid [Term] id: CL:2000072 name: adipose microvascular endothelial cell +def: "Any microvascular endothelial cell that is part of a adipose tissue." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7200 is_a: CL:0002320 ! connective tissue cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell @@ -4311,14 +5987,26 @@ relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue [Term] id: CL:2000073 name: migratory cardiac neural crest cell +def: "Any migratory neural crest cell that is part of a cardiac neural crest." [GOC:TermGenie] is_a: CL:0000333 ! migratory neural crest cell intersection_of: CL:0000333 ! migratory neural crest cell intersection_of: BFO:0000050 UBERON:0000095 ! part of cardiac neural crest relationship: BFO:0000050 UBERON:0000095 ! part of cardiac neural crest +[Term] +id: CL:2000074 +name: splenocyte +def: "Any leukocyte that is part of a spleen." [GOC:TermGenie] +comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. +is_a: CL:0000738 ! leukocyte +intersection_of: CL:0000738 ! leukocyte +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + [Term] id: CL:2000080 name: mesenchymal stem cell of abdominal adipose tissue +def: "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." [GOC:TermGenie] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -4327,6 +6015,7 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: CL:2000093 name: bronchus fibroblast of lung +def: "Any fibroblast of lung that is part of a bronchus." [GOC:TermGenie] is_a: CL:0002553 ! fibroblast of lung intersection_of: CL:0002553 ! fibroblast of lung intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus @@ -4335,6 +6024,7 @@ relationship: BFO:0000050 UBERON:0002185 ! part of bronchus [Term] id: CL:3000000 name: ciliated epithelial cell of esophagus +def: "A ciliated epithelial cell of the esophagus." [GOC:CellBLAST, PMID:29802404] is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus intersection_of: CL:0000067 ! ciliated epithelial cell @@ -4344,6 +6034,7 @@ relationship: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus [Term] id: CL:3000004 name: peripheral sensory neuron +def: "Peripheral sensory neuron." [GOC:CellBLAST, PMID:30096314] is_a: CL:0000101 ! sensory neuron is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron @@ -4352,25 +6043,26 @@ intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involv [Term] id: CL:4023072 name: brain vascular cell +def: "A cell that is part of the brain vasculature." [DOI:10.1101/2022.10.12.511898] is_a: CL:0002319 ! neural cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0008998 ! part of vasculature of brain relationship: BFO:0000050 UBERON:0008998 ! part of vasculature of brain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4023079 name: midbrain-derived inhibitory neuron +def: "A GABAergic inhibitory neuron that is derived from the midbrain." [DOI:10.1101/2022.10.12.511898] is_a: CL:0000540 ! neuron is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000540 ! neuron intersection_of: RO:0002202 UBERON:0001891 ! midbrain relationship: RO:0002202 UBERON:0001891 ! midbrain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4023168 name: somatosensory neuron +def: "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." [PMID:22865660] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: BFO:0000050 UBERON:0003942 ! part of somatosensory system @@ -4389,22 +6081,27 @@ relationship: BFO:0000050 UBERON:0016405 ! part of pulmonary capillary [Term] id: CL:4028004 name: alveolar type 1 fibroblast cell +def: "A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets." [PMID:22268140, PMID:26706109, PMID:28886382, PMID:29489752, PMID:30675802, PMID:33624948, PMID:33707239, PMID:9074756] +comment: A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7. {xref="https://doi.org/10.5281/zenodo.11165918"} is_a: CL:0002241 ! pulmonary interstitial fibroblast is_a: CL:0002553 ! fibroblast of lung relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung -property_value: RO:0002175 NCBITaxon:9606 +relationship: RO:0015004 CL:4037002 ! has characterizing marker set NS forest marker set of alveolar type 1 fibroblast cell (Human Lung). [Term] id: CL:4028006 name: alveolar adventitial fibroblast +def: "A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia." [PMID:26706109, PMID:28886382, PMID:29752282, PMID:30675802, PMID:33208946, PMID:33624948] +comment: A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85. {xref="https://doi.org/10.5281/zenodo.11165918"} is_a: CL:0002241 ! pulmonary interstitial fibroblast is_a: CL:0002553 ! fibroblast of lung relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung -property_value: RO:0002175 NCBITaxon:9606 +relationship: RO:0015004 CL:4037001 ! has characterizing marker set NS forest marker set of alveolar adventitial fibroblast (Human Lung). [Term] id: CL:4030029 name: blood lymphocyte +def: "A lymphocyte located in blood." [https://orcid.org/0000-0001-9990-8331] is_a: CL:0000542 ! lymphocyte is_a: CL:2000001 ! peripheral blood mononuclear cell intersection_of: CL:0000542 ! lymphocyte @@ -4413,6 +6110,7 @@ intersection_of: BFO:0000050 UBERON:0000178 ! part of blood [Term] id: CL:4030031 name: interstitial cell +def: "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes." [PMID:24987007] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0005169 ! part of interstitial tissue @@ -4421,130 +6119,186 @@ relationship: BFO:0000050 UBERON:0005169 ! part of interstitial tissue [Term] id: CL:4030034 name: respiratory ciliated cell +def: "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium." [PMID:18757316, PMID:21364219] is_a: CL:0000064 ! ciliated cell intersection_of: CL:0000064 ! ciliated cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium relationship: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium +[Term] +id: CL:4033005 +name: serous secreting cell of bronchus submucosal gland +def: "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland." [PMID:5487122, PMID:9651178] +is_a: CL:0000152 ! exocrine cell +is_a: CL:0019001 ! tracheobronchial serous cell +intersection_of: CL:0000313 ! serous secreting cell +intersection_of: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland +relationship: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland + [Term] id: CL:4033008 name: vein endothelial cell of respiratory system +def: "A(n) vein endothelial cell that is part of a(n) respiratory system." [PMID:34030460] is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0002543 ! vein endothelial cell intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033017 name: bronchiolar smooth muscle cell +def: "A smooth muscle cell that is part of a bronchiole." [ISBN:9781260462982, PMID:15347627] is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002186 ! part of bronchiole relationship: BFO:0000050 UBERON:0004515 ! part of smooth muscle tissue of bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033018 name: lung megakaryocyte +def: "A megakaryocyte that is resident in the lung connective tissue." [PMID:33351116] is_a: CL:0000556 ! megakaryocyte is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000556 ! megakaryocyte intersection_of: BFO:0000050 UBERON:0000114 ! part of lung connective tissue relationship: BFO:0000050 UBERON:0000114 ! part of lung connective tissue -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:4033020 +name: mucus secreting cell of trachea gland +def: "A mucus secreting cell that is part of a submucosal gland of the trachea." [PMID:18931053, PMID:29656943] +is_a: CL:0000307 ! tracheal epithelial cell +is_a: CL:4033037 ! mucus secreting cell of tracheobronchial tree submucosal gland +intersection_of: CL:0000319 ! mucus secreting cell +intersection_of: BFO:0000050 UBERON:0005203 ! part of trachea gland +relationship: BFO:0000050 UBERON:0005203 ! part of trachea gland + +[Term] +id: CL:4033022 +name: mucus secreting cell of bronchus submucosal gland +def: "A mucus secreting cell of a submucosal gland of the bronchus." [PMID:19965983] +is_a: CL:0002328 ! bronchial epithelial cell +is_a: CL:4033037 ! mucus secreting cell of tracheobronchial tree submucosal gland +intersection_of: CL:0000319 ! mucus secreting cell +intersection_of: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland +relationship: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland + +[Term] +id: CL:4033037 +name: mucus secreting cell of tracheobronchial tree submucosal gland +def: "A mucus secreting cell of a submucosal gland of the tracheobronchial tree." [PMID:30864819] +is_a: CL:0000152 ! exocrine cell +is_a: CL:0000319 ! mucus secreting cell +is_a: CL:0002202 ! epithelial cell of tracheobronchial tree +intersection_of: CL:0000319 ! mucus secreting cell +intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree +intersection_of: BFO:0000050 UBERON:8410077 ! part of airway submucosal gland +relationship: BFO:0000050 UBERON:8410077 ! part of airway submucosal gland [Term] id: CL:4033041 name: CCL3-positive alveolar macrophage +def: "An alveolar macrophage that expresses CCL3." [PMID:37291214] +comment: A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67. {xref="https://doi.org/10.5281/zenodo.11165918"} is_a: CL:0000583 ! alveolar macrophage relationship: RO:0002292 PR:000002123 -property_value: RO:0002175 NCBITaxon:9606 +relationship: RO:0015004 CL:4037004 ! has characterizing marker set NS forest marker set of CCL3-positive alveolar macrophage (Human Lung). [Term] id: CL:4033042 name: metallothionein-positive alveolar macrophage +def: "An alveolar macrophage that expresses metallothionein." [PMID:37291214] +comment: A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41. {xref="https://doi.org/10.5281/zenodo.11165918"} is_a: CL:0000583 ! alveolar macrophage -property_value: RO:0002175 NCBITaxon:9606 +relationship: RO:0015004 CL:4037005 ! has characterizing marker set NS forest marker set of metallothionein-positive alveolar macrophage (Human Lung). [Term] id: CL:4033054 name: perivascular cell +def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." [PMID:24928499, PMID:27889329] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002220 UBERON:0002049 ! adjacent to vasculature relationship: RO:0002220 UBERON:0002049 ! adjacent to vasculature +[Term] +id: CL:4033061 +name: endothelial cell of central vein of liver +def: "An endothelial cell that is part of a central vein of liver." [PMID:28287163] +is_a: CL:0002543 ! vein endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: BFO:0000050 UBERON:0006841 ! part of central vein of liver +relationship: BFO:0000050 UBERON:0006841 ! part of central vein of liver + [Term] id: CL:4037001 name: NS forest marker set of alveolar adventitial fibroblast (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/286133 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/57124 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000168079 ! has part SCARA5 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000174807 ! has part CD248 property_value: STATO:0000663 "0.85" xsd:string [Term] id: CL:4037002 name: NS forest marker set of alveolar type 1 fibroblast cell (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/4060 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/8639 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000131471 ! has part AOC3 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000139329 ! has part LUM property_value: STATO:0000663 "0.7" xsd:string [Term] id: CL:4037003 name: NS forest marker set of alveolar macrophage (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/2168 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/4481 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000038945 ! has part MSR1 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000170323 ! has part FABP4 property_value: STATO:0000663 "0.8" xsd:string [Term] id: CL:4037004 name: NS forest marker set of CCL3-positive alveolar macrophage (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/6374 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/79931 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000050730 ! has part TNIP3 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000163735 ! has part CXCL5 property_value: STATO:0000663 "0.67" xsd:string [Term] id: CL:4037005 name: NS forest marker set of metallothionein-positive alveolar macrophage (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/3162 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/3248 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000100292 ! has part HMOX1 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000164120 ! has part HPGD property_value: STATO:0000663 "0.41" xsd:string [Term] id: CL:4037006 name: NS forest marker set of cell (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/11065 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/51203 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/6241 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/9768 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000137804 ! has part NUSAP1 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000166803 ! has part PCLAF +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000171848 ! has part RRM2 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000175063 ! has part UBE2C property_value: STATO:0000663 "0.26" xsd:string [Term] id: CL:4040003 name: fetal pre-type II pulmonary alveolar epithelial cell +def: "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity." [PMID:1316350] is_a: CL:0000322 ! pulmonary alveolar epithelial cell [Term] id: CL:4040004 name: mesenchymal stem cell of orbital adipose tissue +def: "Any mesenchymal stem cell of adipose tissue that is part of an orbital region." [https://orcid.org/0000-0002-0819-0473] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: BFO:0000050 UBERON:0004088 ! part of orbital region relationship: BFO:0000050 UBERON:0004088 ! part of orbital region -[Term] -id: CLM:0000000 -name: root node - [Term] id: GO:0000011 name: vacuole inheritance +def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization is_a: GO:0048308 ! organelle inheritance intersection_of: GO:0048308 ! organelle inheritance @@ -4554,6 +6308,7 @@ relationship: GOREL:0002003 GO:0005773 ! results in distribution of vacuole [Term] id: GO:0000070 name: mitotic sister chromatid segregation +def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation @@ -4563,6 +6318,7 @@ relationship: BFO:0000050 GO:0140014 ! part of mitotic nuclear division [Term] id: GO:0000139 name: Golgi membrane +def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005794 ! bounding layer of Golgi apparatus @@ -4571,6 +6327,7 @@ relationship: RO:0002007 GO:0005794 ! bounding layer of Golgi apparatus [Term] id: GO:0000226 name: microtubule cytoskeleton organization +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process intersection_of: GO:0016043 ! cellular component organization @@ -4580,6 +6337,7 @@ relationship: RO:0002592 GO:0015630 ! results in organization of microtubule cyt [Term] id: GO:0000228 name: nuclear chromosome +def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: BFO:0000050 GO:0005634 ! part of nucleus @@ -4588,14 +6346,27 @@ relationship: BFO:0000050 GO:0031981 ! part of nuclear lumen [Term] id: GO:0000271 name: polysaccharide biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18154 ! has primary output relationship: RO:0004008 CHEBI:18154 ! has primary output +[Term] +id: GO:0000272 +name: polysaccharide catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:18154 ! has primary input +relationship: RO:0004009 CHEBI:18154 ! has primary input + [Term] id: GO:0000278 name: mitotic cell cycle +def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] +comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. +xref: Wikipedia:Mitosis is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: BFO:0000051 GO:0140014 ! has part mitotic nuclear division @@ -4606,6 +6377,7 @@ relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! Eukaryota [Term] id: GO:0000280 name: nuclear division +def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: GOREL:0002004 GO:0005634 ! results in fission of nucleus @@ -4614,6 +6386,7 @@ relationship: GOREL:0002004 GO:0005634 ! results in fission of nucleus [Term] id: GO:0000313 name: organellar ribosome +def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] is_a: GO:0005840 ! ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0043226 ! part of organelle @@ -4622,11 +6395,13 @@ relationship: BFO:0000050 GO:0043226 ! part of organelle [Term] id: GO:0000323 name: lytic vacuole +def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000740 name: nuclear membrane fusion +def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0071763 ! nuclear membrane organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion @@ -4636,6 +6411,8 @@ relationship: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane [Term] id: GO:0000741 name: karyogamy +def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] +xref: Wikipedia:Karyogamy is_a: GO:0006997 ! nucleus organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0048284 ! organelle fusion @@ -4646,6 +6423,7 @@ relationship: RO:0012008 GO:0005634 ! results in fusion of nucleus [Term] id: GO:0000768 name: syncytium formation by plasma membrane fusion +def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] is_a: GO:0006949 ! syncytium formation is_a: GO:0140253 ! cell-cell fusion intersection_of: GO:0006949 ! syncytium formation @@ -4654,28 +6432,39 @@ intersection_of: BFO:0000051 GO:0045026 ! has part plasma membrane fusion [Term] id: GO:0000785 name: chromatin +def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] +comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. +xref: NIF_Subcellular:sao1615953555 is_a: GO:0032993 ! protein-DNA complex relationship: BFO:0000050 GO:0005694 ! part of chromosome [Term] id: GO:0000791 name: euchromatin +def: "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] +xref: NIF_Subcellular:sao445485807 +xref: Wikipedia:Euchromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000792 name: heterochromatin +def: "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] +xref: NIF_Subcellular:sao581845896 +xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000819 name: sister chromatid segregation +def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0051276 ! chromosome organization is_a: GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0000902 name: cell morphogenesis +def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000000 ! results in morphogenesis of cell @@ -4684,6 +6473,7 @@ relationship: RO:0002298 CL:0000000 ! results in morphogenesis of cell [Term] id: GO:0001501 name: skeletal system development +def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001434 ! results in development of skeletal system @@ -4692,6 +6482,9 @@ relationship: RO:0002296 UBERON:0001434 ! results in development of skeletal sys [Term] id: GO:0001503 name: ossification +def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] +comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. +xref: Wikipedia:Ossification is_a: GO:0032501 ! multicellular organismal process intersection_of: GO:0032501 ! multicellular organismal process intersection_of: RO:0002297 UBERON:0001474 ! results in formation of bone element @@ -4700,11 +6493,15 @@ relationship: RO:0002297 UBERON:0001474 ! results in formation of bone element [Term] id: GO:0001508 name: action potential +def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] +comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0001525 name: angiogenesis +def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] +xref: Wikipedia:Angiogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001981 ! results in formation of blood vessel @@ -4714,11 +6511,14 @@ relationship: RO:0002297 UBERON:0001981 ! results in formation of blood vessel [Term] id: GO:0001539 name: cilium or flagellum-dependent cell motility +def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] +comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. is_a: GO:0048870 ! cell motility [Term] id: GO:0001555 name: oocyte growth +def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0040007 ! growth @@ -4731,6 +6531,8 @@ relationship: RO:0002343 CL:0000023 ! results in growth of oocyte [Term] id: GO:0001556 name: oocyte maturation +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/] +xref: Wikipedia:Oocyte_maturation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation @@ -4743,6 +6545,7 @@ relationship: RO:0002299 CL:0000023 ! results in maturation of oocyte [Term] id: GO:0001558 name: regulation of cell growth +def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation @@ -4752,6 +6555,7 @@ relationship: RO:0002211 GO:0016049 ! regulates cell growth [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus +def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] is_a: GO:0001558 ! regulation of cell growth intersection_of: GO:0001558 ! regulation of cell growth intersection_of: BFO:0000050 GO:0051716 ! part of cellular response to stimulus @@ -4760,6 +6564,7 @@ relationship: BFO:0000050 GO:0051716 ! part of cellular response to stimulus [Term] id: GO:0001568 name: blood vessel development +def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001981 ! results in development of blood vessel @@ -4769,6 +6574,7 @@ relationship: RO:0002296 UBERON:0001981 ! results in development of blood vessel [Term] id: GO:0001569 name: branching involved in blood vessel morphogenesis +def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis @@ -4777,6 +6583,8 @@ relationship: BFO:0000050 GO:0001525 ! part of angiogenesis [Term] id: GO:0001570 name: vasculogenesis +def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] +xref: Wikipedia:Vasculogenesis is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002297 UBERON:0001981 ! results in formation of blood vessel @@ -4786,6 +6594,7 @@ relationship: RO:0002297 UBERON:0001981 ! results in formation of blood vessel [Term] id: GO:0001578 name: microtubule bundle formation +def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: RO:0000057 GO:0005874 ! has participant microtubule relationship: RO:0002297 GO:0097427 ! results in formation of microtubule bundle @@ -4793,31 +6602,50 @@ relationship: RO:0002297 GO:0097427 ! results in formation of microtubule bundle [Term] id: GO:0001654 name: eye development +def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] +xref: Wikipedia:Eye_development is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000970 ! results in development of eye relationship: BFO:0000050 GO:0150063 ! part of visual system development relationship: RO:0002296 UBERON:0000970 ! results in development of eye +[Term] +id: GO:0001655 +name: urogenital system development +def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048731 ! system development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: RO:0002296 UBERON:0004122 ! results in development of genitourinary system +relationship: BFO:0000051 GO:0072001 ! has part renal system development +relationship: RO:0002296 UBERON:0004122 ! results in development of genitourinary system + [Term] id: GO:0001659 name: temperature homeostasis +def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl] +xref: Wikipedia:Thermoregulation is_a: GO:0048871 ! multicellular organismal-level homeostasis [Term] id: GO:0001666 name: response to hypoxia +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] +comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. is_a: GO:0006950 ! response to stress is_a: GO:0036293 ! response to decreased oxygen levels [Term] id: GO:0001667 name: ameboidal-type cell migration +def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] +comment: Note that this term refers to a mode of migration rather than to any particular cell type. is_a: GO:0016477 ! cell migration [Term] id: GO:0001674 name: female germ cell nucleus +def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] is_a: GO:0043073 ! germ cell nucleus intersection_of: GO:0005634 ! nucleus intersection_of: BFO:0000050 CL:0000021 ! part of female germ cell @@ -4827,21 +6655,33 @@ relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! Eukaryota [Term] id: GO:0001677 name: formation of translation initiation ternary complex +def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] is_a: GO:0022618 ! protein-RNA complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex relationship: BFO:0000050 GO:0006413 ! part of translational initiation relationship: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex +[Term] +id: GO:0001678 +name: intracellular glucose homeostasis +def: "A homeostatic process involved in the maintenance of a steady state level of glucose within a cell." [GOC:dph, GOC:go_curators, GOC:tb] +is_a: GO:0019725 ! cellular homeostasis +intersection_of: GO:0019725 ! cellular homeostasis +intersection_of: RO:0002332 CHEBI:4167 ! regulates levels of +relationship: RO:0002332 CHEBI:4167 ! regulates levels of + [Term] id: GO:0001696 name: gastric acid secretion +def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] is_a: GO:0022600 ! digestive system process is_a: GO:0046717 ! acid secretion [Term] id: GO:0001700 name: embryonic development via the syncytial blastoderm +def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching relationship: RO:0002160 NCBITaxon:50557 ! Insecta relationship: RO:0002162 NCBITaxon:50557 {all_only="true"} ! Insecta @@ -4849,6 +6689,7 @@ relationship: RO:0002162 NCBITaxon:50557 {all_only="true"} ! Insecta [Term] id: GO:0001701 name: in utero embryonic development +def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development relationship: RO:0002160 NCBITaxon:32525 ! Theria relationship: RO:0002162 NCBITaxon:32525 {all_only="true"} ! Theria @@ -4856,6 +6697,7 @@ relationship: RO:0002162 NCBITaxon:32525 {all_only="true"} ! Theria [Term] id: GO:0001704 name: formation of primary germ layer +def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000923 ! results in formation of germ layer @@ -4865,6 +6707,7 @@ relationship: RO:0002297 UBERON:0000923 ! results in formation of germ layer [Term] id: GO:0001705 name: ectoderm formation +def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000924 ! results in formation of ectoderm @@ -4874,6 +6717,7 @@ relationship: RO:0002297 UBERON:0000924 ! results in formation of ectoderm [Term] id: GO:0001706 name: endoderm formation +def: "The formation of the endoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000925 ! results in formation of endoderm @@ -4883,6 +6727,7 @@ relationship: RO:0002297 UBERON:0000925 ! results in formation of endoderm [Term] id: GO:0001707 name: mesoderm formation +def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000926 ! results in formation of mesoderm @@ -4892,6 +6737,7 @@ relationship: RO:0002297 UBERON:0000926 ! results in formation of mesoderm [Term] id: GO:0001743 name: lens placode formation +def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003073 ! results in formation of lens placode @@ -4901,6 +6747,7 @@ relationship: RO:0002297 UBERON:0003073 ! results in formation of lens placode [Term] id: GO:0001745 name: compound eye morphogenesis +def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] is_a: GO:0048592 ! eye morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye @@ -4912,6 +6759,7 @@ relationship: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound e [Term] id: GO:0001751 name: compound eye photoreceptor cell differentiation +def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] is_a: GO:0001754 ! eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell @@ -4921,6 +6769,7 @@ relationship: RO:0002315 CL:2000019 ! results in acquisition of features of comp [Term] id: GO:0001754 name: eye photoreceptor cell differentiation +def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell @@ -4930,6 +6779,7 @@ relationship: RO:0002315 CL:0000287 ! results in acquisition of features of eye [Term] id: GO:0001755 name: neural crest cell migration +def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] is_a: GO:0090497 ! mesenchymal cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000333 ! results in movement of migratory neural crest cell @@ -4939,6 +6789,8 @@ relationship: RO:0002565 CL:0000333 ! results in movement of migratory neural cr [Term] id: GO:0001756 name: somitogenesis +def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] +xref: Wikipedia:Somitogenesis is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0035282 ! segmentation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis @@ -4951,12 +6803,16 @@ relationship: RO:0002297 UBERON:0002329 ! results in formation of somite [Term] id: GO:0001763 name: morphogenesis of a branching structure +def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001764 name: neuron migration +def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators] +xref: Wikipedia:Neural_development#Neuron_migration +xref: Wikipedia:Neuron_migration is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000540 ! results in movement of neuron @@ -4966,6 +6822,7 @@ relationship: RO:0002565 CL:0000540 ! results in movement of neuron [Term] id: GO:0001767 name: establishment of lymphocyte polarity +def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000542 ! occurs in lymphocyte @@ -4975,6 +6832,7 @@ relationship: BFO:0000066 CL:0000542 ! occurs in lymphocyte [Term] id: GO:0001768 name: establishment of T cell polarity +def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] is_a: GO:0001767 ! establishment of lymphocyte polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell @@ -4984,6 +6842,7 @@ relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0001773 name: myeloid dendritic cell activation +def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell @@ -4992,6 +6851,7 @@ relationship: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell [Term] id: GO:0001775 name: cell activation +def: "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators] is_a: GO:0009987 ! cellular process is_a: GO:0032501 ! multicellular organismal process relationship: RO:0002160 NCBITaxon:33208 ! Metazoa @@ -5000,6 +6860,8 @@ relationship: RO:0002162 NCBITaxon:33208 {all_only="true"} ! Metazoa [Term] id: GO:0001776 name: leukocyte homeostasis +def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149] +comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells @@ -5011,6 +6873,7 @@ relationship: RO:0012003 CL:0000738 ! acts on population of leukocyte [Term] id: GO:0001777 name: T cell homeostatic proliferation +def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0042098 ! T cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0042592 ! part of homeostatic process @@ -5020,12 +6883,15 @@ relationship: BFO:0000050 GO:0043029 ! part of T cell homeostasis [Term] id: GO:0001816 name: cytokine production +def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0010467 ! gene expression is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001817 name: regulation of cytokine production +def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation @@ -5035,6 +6901,7 @@ relationship: RO:0002211 GO:0001816 ! regulates cytokine production [Term] id: GO:0001818 name: negative regulation of cytokine production +def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051241 ! negative regulation of multicellular organismal process @@ -5045,6 +6912,7 @@ relationship: RO:0002212 GO:0001816 ! negatively regulates cytokine production [Term] id: GO:0001819 name: positive regulation of cytokine production +def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051240 ! positive regulation of multicellular organismal process @@ -5055,6 +6923,7 @@ relationship: RO:0002213 GO:0001816 ! positively regulates cytokine production [Term] id: GO:0001820 name: serotonin secretion +def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149] is_a: GO:0006837 ! serotonin transport is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion @@ -5063,6 +6932,8 @@ intersection_of: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0001824 name: blastocyst development +def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000358 ! results in development of blastocyst @@ -5074,6 +6945,8 @@ relationship: RO:0002296 UBERON:0000358 ! results in development of blastocyst [Term] id: GO:0001825 name: blastocyst formation +def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000358 ! results in formation of blastocyst @@ -5083,6 +6956,8 @@ relationship: RO:0002297 UBERON:0000358 ! results in formation of blastocyst [Term] id: GO:0001826 name: inner cell mass cell differentiation +def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell @@ -5092,6 +6967,8 @@ relationship: RO:0002315 CL:2000020 ! results in acquisition of features of inne [Term] id: GO:0001829 name: trophectodermal cell differentiation +def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell @@ -5101,6 +6978,8 @@ relationship: RO:0002315 CL:1000274 ! results in acquisition of features of trop [Term] id: GO:0001831 name: trophectodermal cellular morphogenesis +def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. is_a: GO:0000902 ! cell morphogenesis is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -5111,6 +6990,8 @@ relationship: RO:0002298 CL:1000274 ! results in morphogenesis of trophectoderma [Term] id: GO:0001832 name: blastocyst growth +def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. is_a: GO:0048589 ! developmental growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 UBERON:0000358 ! results in growth of blastocyst @@ -5120,6 +7001,8 @@ relationship: RO:0002343 UBERON:0000358 ! results in growth of blastocyst [Term] id: GO:0001833 name: inner cell mass cell proliferation +def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell @@ -5129,6 +7012,8 @@ relationship: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell [Term] id: GO:0001834 name: trophectodermal cell proliferation +def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell @@ -5138,6 +7023,7 @@ relationship: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell [Term] id: GO:0001837 name: epithelial to mesenchymal transition +def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell @@ -5147,12 +7033,14 @@ relationship: RO:0004009 CL:0000066 ! has primary input epithelial cell [Term] id: GO:0001838 name: embryonic epithelial tube formation +def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0072175 ! epithelial tube formation relationship: BFO:0000050 GO:0016331 ! part of morphogenesis of embryonic epithelium [Term] id: GO:0001839 name: neural plate morphogenesis +def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate @@ -5162,6 +7050,7 @@ relationship: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural pla [Term] id: GO:0001840 name: neural plate development +def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003075 ! results in development of neural plate @@ -5171,6 +7060,8 @@ relationship: RO:0002296 UBERON:0003075 ! results in development of neural plate [Term] id: GO:0001841 name: neural tube formation +def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] +xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001049 ! results in formation of neural tube @@ -5180,6 +7071,7 @@ relationship: RO:0002297 UBERON:0001049 ! results in formation of neural tube [Term] id: GO:0001842 name: neural fold formation +def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold @@ -5191,6 +7083,8 @@ relationship: RO:0002297 UBERON:0005062 ! results in formation of neural fold [Term] id: GO:0001878 name: response to yeast +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091] +comment: defined as response to Saccharomycotina (true yeasts). This excludes fission yeast. is_a: GO:0009620 ! response to fungus intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 NCBITaxon:147537 ! has primary input Saccharomycotina @@ -5199,6 +7093,7 @@ relationship: RO:0004009 NCBITaxon:147537 ! has primary input Saccharomycotina [Term] id: GO:0001885 name: endothelial cell development +def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000115 ! results in development of endothelial cell @@ -5208,21 +7103,34 @@ relationship: RO:0002296 CL:0000115 ! results in development of endothelial cell [Term] id: GO:0001886 name: endothelial cell morphogenesis +def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell relationship: BFO:0000050 GO:0001885 ! part of endothelial cell development relationship: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell +[Term] +id: GO:0001889 +name: liver development +def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] +is_a: GO:0048732 ! gland development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: RO:0002296 UBERON:0002107 ! results in development of liver +relationship: BFO:0000050 GO:0061008 ! part of hepaticobiliary system development +relationship: RO:0002296 UBERON:0002107 ! results in development of liver + [Term] id: GO:0001894 name: tissue homeostasis +def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete] is_a: GO:0060249 ! anatomical structure homeostasis relationship: BFO:0000050 GO:0048871 ! part of multicellular organismal-level homeostasis [Term] id: GO:0001935 name: endothelial cell proliferation +def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000115 ! acts on population of endothelial cell @@ -5231,6 +7139,7 @@ relationship: RO:0012003 CL:0000115 ! acts on population of endothelial cell [Term] id: GO:0001936 name: regulation of endothelial cell proliferation +def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation @@ -5239,6 +7148,7 @@ relationship: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation [Term] id: GO:0001937 name: negative regulation of endothelial cell proliferation +def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -5248,6 +7158,7 @@ relationship: RO:0002212 GO:0001935 ! negatively regulates endothelial cell prol [Term] id: GO:0001938 name: positive regulation of endothelial cell proliferation +def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -5257,6 +7168,7 @@ relationship: RO:0002213 GO:0001935 ! positively regulates endothelial cell prol [Term] id: GO:0001944 name: vasculature development +def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002049 ! results in development of vasculature @@ -5266,6 +7178,7 @@ relationship: RO:0002296 UBERON:0002049 ! results in development of vasculature [Term] id: GO:0001955 name: blood vessel maturation +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel @@ -5275,11 +7188,15 @@ relationship: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel [Term] id: GO:0001957 name: intramembranous ossification +def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437] +comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. +xref: Wikipedia:Intramembranous_ossification is_a: GO:0036072 ! direct ossification [Term] id: GO:0002009 name: morphogenesis of an epithelium +def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium @@ -5289,6 +7206,7 @@ relationship: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet +def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet @@ -5297,11 +7215,13 @@ relationship: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial [Term] id: GO:0002027 name: regulation of heart rate +def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] is_a: GO:0008016 ! regulation of heart contraction [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation +def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation @@ -5312,6 +7232,7 @@ relationship: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferat [Term] id: GO:0002053 name: positive regulation of mesenchymal cell proliferation +def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -5321,6 +7242,7 @@ relationship: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell prol [Term] id: GO:0002062 name: chondrocyte differentiation +def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte @@ -5330,6 +7252,7 @@ relationship: RO:0002315 CL:0000138 ! results in acquisition of features of chon [Term] id: GO:0002063 name: chondrocyte development +def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000138 ! results in development of chondrocyte @@ -5339,6 +7262,7 @@ relationship: RO:0002296 CL:0000138 ! results in development of chondrocyte [Term] id: GO:0002064 name: epithelial cell development +def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000066 ! results in development of epithelial cell @@ -5348,6 +7272,7 @@ relationship: RO:0002296 CL:0000066 ! results in development of epithelial cell [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation +def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell @@ -5356,6 +7281,7 @@ relationship: RO:0002315 CL:0000075 ! results in acquisition of features of colu [Term] id: GO:0002066 name: columnar/cuboidal epithelial cell development +def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell @@ -5365,6 +7291,7 @@ relationship: RO:0002296 CL:0000075 ! results in development of columnar/cuboida [Term] id: GO:0002067 name: glandular epithelial cell differentiation +def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000150 ! results in acquisition of features of glandular epithelial cell @@ -5373,6 +7300,7 @@ relationship: RO:0002315 CL:0000150 ! results in acquisition of features of glan [Term] id: GO:0002068 name: glandular epithelial cell development +def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000150 ! results in development of glandular epithelial cell @@ -5382,6 +7310,7 @@ relationship: RO:0002296 CL:0000150 ! results in development of glandular epithe [Term] id: GO:0002069 name: columnar/cuboidal epithelial cell maturation +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell @@ -5391,6 +7320,7 @@ relationship: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal [Term] id: GO:0002070 name: epithelial cell maturation +def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell @@ -5400,6 +7330,7 @@ relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell [Term] id: GO:0002071 name: glandular epithelial cell maturation +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000150 ! results in maturation of glandular epithelial cell @@ -5409,6 +7340,7 @@ relationship: RO:0002299 CL:0000150 ! results in maturation of glandular epithel [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development +def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup @@ -5418,6 +7350,7 @@ relationship: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation +def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045995 ! regulation of embryonic development @@ -5429,6 +7362,7 @@ relationship: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell [Term] id: GO:0002087 name: regulation of respiratory gaseous exchange by nervous system process +def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] is_a: GO:0044065 ! regulation of respiratory system process is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process @@ -5437,6 +7371,7 @@ intersection_of: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange [Term] id: GO:0002088 name: lens development in camera-type eye +def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye @@ -5446,6 +7381,7 @@ relationship: RO:0002296 UBERON:0000965 ! results in development of lens of came [Term] id: GO:0002089 name: lens morphogenesis in camera-type eye +def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye @@ -5456,6 +7392,7 @@ relationship: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of ca [Term] id: GO:0002158 name: osteoclast proliferation +def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd] is_a: GO:0070661 ! leukocyte proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000092 ! acts on population of osteoclast @@ -5464,6 +7401,7 @@ relationship: RO:0012003 CL:0000092 ! acts on population of osteoclast [Term] id: GO:0002213 name: defense response to insect +def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] is_a: GO:0006952 ! defense response intersection_of: GO:0006952 ! defense response intersection_of: RO:0004009 NCBITaxon:50557 ! has primary input Insecta @@ -5472,6 +7410,7 @@ relationship: RO:0004009 NCBITaxon:50557 ! has primary input Insecta [Term] id: GO:0002232 name: leukocyte chemotaxis involved in inflammatory response +def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002523 ! leukocyte migration involved in inflammatory response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis @@ -5480,6 +7419,7 @@ intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002233 name: leukocyte chemotaxis involved in immune response +def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002522 ! leukocyte migration involved in immune response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis @@ -5488,6 +7428,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002244 name: hematopoietic progenitor cell differentiation +def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell @@ -5497,18 +7438,28 @@ relationship: RO:0002315 CL:0008001 ! results in acquisition of features of hema [Term] id: GO:0002250 name: adaptive immune response +def: "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, ISBN:0781735149] +xref: Wikipedia:Adaptive_immune_system is_a: GO:0006955 ! immune response relationship: RO:0002160 NCBITaxon:33208 ! Metazoa relationship: RO:0002162 NCBITaxon:33208 {all_only="true"} ! Metazoa +[Term] +id: GO:0002251 +name: organ or tissue specific immune response +def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal] +is_a: GO:0006955 ! immune response + [Term] id: GO:0002252 name: immune effector process +def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002376 ! immune system process [Term] id: GO:0002260 name: lymphocyte homeostasis +def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] is_a: GO:0001776 ! leukocyte homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000542 ! acts on population of lymphocyte @@ -5517,6 +7468,7 @@ relationship: RO:0012003 CL:0000542 ! acts on population of lymphocyte [Term] id: GO:0002262 name: myeloid cell homeostasis +def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells @@ -5526,6 +7478,7 @@ relationship: RO:0012003 CL:0000763 ! acts on population of myeloid cell [Term] id: GO:0002263 name: cell activation involved in immune response +def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0001775 ! cell activation is_a: GO:0002252 ! immune effector process intersection_of: GO:0001775 ! cell activation @@ -5535,6 +7488,7 @@ relationship: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002264 name: endothelial cell activation involved in immune response +def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0042118 ! endothelial cell activation intersection_of: GO:0042118 ! endothelial cell activation @@ -5543,6 +7497,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002269 name: leukocyte activation involved in inflammatory response +def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response @@ -5551,6 +7506,7 @@ relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002274 name: myeloid leukocyte activation +def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte @@ -5559,12 +7515,14 @@ relationship: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte [Term] id: GO:0002275 name: myeloid cell activation involved in immune response +def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002277 name: myeloid dendritic cell activation involved in immune response +def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002275 ! myeloid cell activation involved in immune response intersection_of: GO:0001773 ! myeloid dendritic cell activation @@ -5573,6 +7531,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002280 name: monocyte activation involved in immune response +def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042117 ! monocyte activation intersection_of: GO:0042117 ! monocyte activation @@ -5581,6 +7540,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002281 name: macrophage activation involved in immune response +def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0042116 ! macrophage activation intersection_of: GO:0042116 ! macrophage activation @@ -5590,6 +7550,7 @@ relationship: BFO:0000050 GO:0002275 ! part of myeloid cell activation involved [Term] id: GO:0002284 name: myeloid dendritic cell differentiation involved in immune response +def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response is_a: GO:0043011 ! myeloid dendritic cell differentiation intersection_of: GO:0043011 ! myeloid dendritic cell differentiation @@ -5598,6 +7559,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002285 name: lymphocyte activation involved in immune response +def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0046649 ! lymphocyte activation @@ -5606,6 +7568,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002286 name: T cell activation involved in immune response +def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042110 ! T cell activation intersection_of: GO:0042110 ! T cell activation @@ -5614,6 +7577,8 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002292 name: T cell differentiation involved in immune response +def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0030217 ! T cell differentiation intersection_of: GO:0030217 ! T cell differentiation @@ -5622,6 +7587,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002309 name: T cell proliferation involved in immune response +def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0042098 ! T cell proliferation intersection_of: GO:0042098 ! T cell proliferation @@ -5630,6 +7596,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002318 name: myeloid progenitor cell differentiation +def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell @@ -5638,6 +7605,7 @@ relationship: RO:0002315 CL:0000839 ! results in acquisition of features of myel [Term] id: GO:0002320 name: lymphoid progenitor cell differentiation +def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000838 ! results in acquisition of features of lymphoid lineage restricted progenitor cell @@ -5646,11 +7614,13 @@ relationship: RO:0002315 CL:0000838 ! results in acquisition of features of lymp [Term] id: GO:0002351 name: serotonin production involved in inflammatory response +def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002366 name: leukocyte activation involved in immune response +def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation @@ -5659,6 +7629,8 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002367 name: cytokine production involved in immune response +def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response intersection_of: GO:0001816 ! cytokine production @@ -5668,6 +7640,8 @@ relationship: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002369 name: T cell cytokine production +def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002456 ! T cell mediated immunity intersection_of: GO:0001816 ! cytokine production @@ -5676,6 +7650,8 @@ intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell [Term] id: GO:0002371 name: dendritic cell cytokine production +def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0001816 ! cytokine production @@ -5685,6 +7661,8 @@ relationship: RO:0002608 CL:0000451 ! process has causal agent dendritic cell [Term] id: GO:0002372 name: myeloid dendritic cell cytokine production +def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0002371 ! dendritic cell cytokine production is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0061082 ! myeloid leukocyte cytokine production @@ -5695,11 +7673,26 @@ relationship: RO:0002608 CL:0000782 ! process has causal agent myeloid dendritic [Term] id: GO:0002376 name: immune system process +def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] +comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). +xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process +[Term] +id: GO:0002384 +name: hepatic immune response +def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +is_a: GO:0002251 ! organ or tissue specific immune response +intersection_of: GO:0006955 ! immune response +intersection_of: BFO:0000066 UBERON:0002107 ! occurs in liver +relationship: BFO:0000066 UBERON:0002107 ! occurs in liver +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002162 NCBITaxon:7742 {all_only="true"} ! Vertebrata + [Term] id: GO:0002396 name: MHC protein complex assembly +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] is_a: GO:0065003 ! protein-containing complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex @@ -5708,6 +7701,7 @@ relationship: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex [Term] id: GO:0002399 name: MHC class II protein complex assembly +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042613 ! results in assembly of MHC class II protein complex @@ -5716,6 +7710,7 @@ relationship: RO:0002588 GO:0042613 ! results in assembly of MHC class II protei [Term] id: GO:0002407 name: dendritic cell chemotaxis +def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0036336 ! dendritic cell migration intersection_of: GO:0006935 ! chemotaxis @@ -5724,6 +7719,7 @@ intersection_of: RO:0002565 CL:0000451 ! results in movement of dendritic cell [Term] id: GO:0002408 name: myeloid dendritic cell chemotaxis +def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0002407 ! dendritic cell chemotaxis is_a: GO:0097529 ! myeloid leukocyte migration intersection_of: GO:0006935 ! chemotaxis @@ -5733,12 +7729,15 @@ relationship: RO:0002565 CL:0000782 ! results in movement of myeloid dendritic c [Term] id: GO:0002440 name: production of molecular mediator of immune response +def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0002376 ! immune system process is_a: GO:0010467 ! gene expression [Term] id: GO:0002442 name: serotonin secretion involved in inflammatory response +def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0001820 ! serotonin secretion intersection_of: GO:0001820 ! serotonin secretion intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response @@ -5747,6 +7746,7 @@ relationship: BFO:0000050 GO:0002351 ! part of serotonin production involved in [Term] id: GO:0002443 name: leukocyte mediated immunity +def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002252 ! immune effector process intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000738 ! process has causal agent leukocyte @@ -5757,6 +7757,7 @@ relationship: RO:0002608 CL:0000738 ! process has causal agent leukocyte [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity +def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte @@ -5765,6 +7766,7 @@ relationship: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte [Term] id: GO:0002449 name: lymphocyte mediated immunity +def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000542 ! process has causal agent lymphocyte @@ -5773,6 +7775,7 @@ relationship: RO:0002608 CL:0000542 ! process has causal agent lymphocyte [Term] id: GO:0002456 name: T cell mediated immunity +def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0002376 ! immune system process @@ -5782,6 +7785,7 @@ relationship: RO:0002608 CL:0000084 ! process has causal agent T cell [Term] id: GO:0002457 name: T cell antigen processing and presentation +def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell @@ -5791,11 +7795,13 @@ relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002468 name: dendritic cell antigen processing and presentation +def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000451 ! occurs in dendritic cell @@ -5804,6 +7810,7 @@ relationship: BFO:0000066 CL:0000451 ! occurs in dendritic cell [Term] id: GO:0002469 name: myeloid dendritic cell antigen processing and presentation +def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell @@ -5812,6 +7819,7 @@ relationship: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell [Term] id: GO:0002471 name: monocyte antigen processing and presentation +def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000576 ! occurs in monocyte @@ -5820,6 +7828,7 @@ relationship: BFO:0000066 CL:0000576 ! occurs in monocyte [Term] id: GO:0002472 name: macrophage antigen processing and presentation +def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage @@ -5828,11 +7837,13 @@ relationship: BFO:0000066 CL:0000235 ! occurs in macrophage [Term] id: GO:0002504 name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002520 name: immune system development +def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development @@ -5842,6 +7853,7 @@ relationship: RO:0002296 UBERON:0002405 ! results in development of immune syste [Term] id: GO:0002521 name: leukocyte differentiation +def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte @@ -5851,6 +7863,7 @@ relationship: RO:0002315 CL:0000738 ! results in acquisition of features of leuk [Term] id: GO:0002522 name: leukocyte migration involved in immune response +def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] is_a: GO:0002252 ! immune effector process is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration @@ -5860,6 +7873,7 @@ relationship: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002523 name: leukocyte migration involved in inflammatory response +def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response @@ -5868,12 +7882,14 @@ relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002532 name: production of molecular mediator involved in inflammatory response +def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] is_a: GO:0032501 ! multicellular organismal process relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002534 name: cytokine production involved in inflammatory response +def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] is_a: GO:0001816 ! cytokine production is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response intersection_of: GO:0001816 ! cytokine production @@ -5882,6 +7898,7 @@ intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002548 name: monocyte chemotaxis +def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0071674 ! mononuclear cell migration is_a: GO:0097529 ! myeloid leukocyte migration @@ -5892,6 +7909,7 @@ relationship: RO:0002565 CL:0000576 ! results in movement of monocyte [Term] id: GO:0002572 name: pro-T cell differentiation +def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149] is_a: GO:0002320 ! lymphoid progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000827 ! results in acquisition of features of pro-T cell @@ -5901,6 +7919,7 @@ relationship: RO:0002315 CL:0000827 ! results in acquisition of features of pro- [Term] id: GO:0002573 name: myeloid leukocyte differentiation +def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation @@ -5910,6 +7929,7 @@ relationship: RO:0002315 CL:0000766 ! results in acquisition of features of myel [Term] id: GO:0002577 name: regulation of antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019882 ! regulates antigen processing and presentation @@ -5918,6 +7938,7 @@ relationship: RO:0002211 GO:0019882 ! regulates antigen processing and presentat [Term] id: GO:0002578 name: negative regulation of antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002683 ! negative regulation of immune system process intersection_of: GO:0065007 ! biological regulation @@ -5927,6 +7948,7 @@ relationship: RO:0002212 GO:0019882 ! negatively regulates antigen processing an [Term] id: GO:0002579 name: positive regulation of antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002684 ! positive regulation of immune system process intersection_of: GO:0065007 ! biological regulation @@ -5936,6 +7958,7 @@ relationship: RO:0002213 GO:0019882 ! positively regulates antigen processing an [Term] id: GO:0002580 name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002504 ! regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II @@ -5944,6 +7967,7 @@ relationship: RO:0002211 GO:0002504 ! regulates antigen processing and presentat [Term] id: GO:0002581 name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation @@ -5953,6 +7977,7 @@ relationship: RO:0002212 GO:0002504 ! negatively regulates antigen processing an [Term] id: GO:0002582 name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation @@ -5962,6 +7987,7 @@ relationship: RO:0002213 GO:0002504 ! positively regulates antigen processing an [Term] id: GO:0002604 name: regulation of dendritic cell antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002468 ! regulates dendritic cell antigen processing and presentation @@ -5970,6 +7996,7 @@ relationship: RO:0002211 GO:0002468 ! regulates dendritic cell antigen processin [Term] id: GO:0002605 name: negative regulation of dendritic cell antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -5979,6 +8006,7 @@ relationship: RO:0002212 GO:0002468 ! negatively regulates dendritic cell antige [Term] id: GO:0002606 name: positive regulation of dendritic cell antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -5988,6 +8016,7 @@ relationship: RO:0002213 GO:0002468 ! positively regulates dendritic cell antige [Term] id: GO:0002607 name: regulation of myeloid dendritic cell antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002469 ! regulates myeloid dendritic cell antigen processing and presentation @@ -5996,6 +8025,7 @@ relationship: RO:0002211 GO:0002469 ! regulates myeloid dendritic cell antigen p [Term] id: GO:0002608 name: negative regulation of myeloid dendritic cell antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6005,6 +8035,7 @@ relationship: RO:0002212 GO:0002469 ! negatively regulates myeloid dendritic cel [Term] id: GO:0002609 name: positive regulation of myeloid dendritic cell antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6014,6 +8045,7 @@ relationship: RO:0002213 GO:0002469 ! positively regulates myeloid dendritic cel [Term] id: GO:0002613 name: regulation of monocyte antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002471 ! regulates monocyte antigen processing and presentation @@ -6022,6 +8054,7 @@ relationship: RO:0002211 GO:0002471 ! regulates monocyte antigen processing and [Term] id: GO:0002614 name: negative regulation of monocyte antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6031,6 +8064,7 @@ relationship: RO:0002212 GO:0002471 ! negatively regulates monocyte antigen proc [Term] id: GO:0002615 name: positive regulation of monocyte antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6040,6 +8074,7 @@ relationship: RO:0002213 GO:0002471 ! positively regulates monocyte antigen proc [Term] id: GO:0002616 name: regulation of macrophage antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002472 ! regulates macrophage antigen processing and presentation @@ -6048,6 +8083,7 @@ relationship: RO:0002211 GO:0002472 ! regulates macrophage antigen processing an [Term] id: GO:0002617 name: negative regulation of macrophage antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6057,6 +8093,7 @@ relationship: RO:0002212 GO:0002472 ! negatively regulates macrophage antigen pr [Term] id: GO:0002618 name: positive regulation of macrophage antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6066,6 +8103,7 @@ relationship: RO:0002213 GO:0002472 ! positively regulates macrophage antigen pr [Term] id: GO:0002625 name: regulation of T cell antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6075,6 +8113,7 @@ relationship: RO:0002211 GO:0002457 ! regulates T cell antigen processing and pr [Term] id: GO:0002626 name: negative regulation of T cell antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002710 ! negative regulation of T cell mediated immunity @@ -6085,6 +8124,7 @@ relationship: RO:0002212 GO:0002457 ! negatively regulates T cell antigen proces [Term] id: GO:0002627 name: positive regulation of T cell antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002711 ! positive regulation of T cell mediated immunity @@ -6095,6 +8135,7 @@ relationship: RO:0002213 GO:0002457 ! positively regulates T cell antigen proces [Term] id: GO:0002682 name: regulation of immune system process +def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002376 ! regulates immune system process @@ -6103,6 +8144,7 @@ relationship: RO:0002211 GO:0002376 ! regulates immune system process [Term] id: GO:0002683 name: negative regulation of immune system process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation @@ -6112,6 +8154,7 @@ relationship: RO:0002212 GO:0002376 ! negatively regulates immune system process [Term] id: GO:0002684 name: positive regulation of immune system process +def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation @@ -6121,6 +8164,7 @@ relationship: RO:0002213 GO:0002376 ! positively regulates immune system process [Term] id: GO:0002685 name: regulation of leukocyte migration +def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation @@ -6130,6 +8174,7 @@ relationship: RO:0002211 GO:0050900 ! regulates leukocyte migration [Term] id: GO:0002686 name: negative regulation of leukocyte migration +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030336 ! negative regulation of cell migration @@ -6140,6 +8185,7 @@ relationship: RO:0002212 GO:0050900 ! negatively regulates leukocyte migration [Term] id: GO:0002687 name: positive regulation of leukocyte migration +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030335 ! positive regulation of cell migration @@ -6150,6 +8196,7 @@ relationship: RO:0002213 GO:0050900 ! positively regulates leukocyte migration [Term] id: GO:0002688 name: regulation of leukocyte chemotaxis +def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation @@ -6159,6 +8206,7 @@ relationship: RO:0002211 GO:0030595 ! regulates leukocyte chemotaxis [Term] id: GO:0002689 name: negative regulation of leukocyte chemotaxis +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050922 ! negative regulation of chemotaxis @@ -6169,6 +8217,7 @@ relationship: RO:0002212 GO:0030595 ! negatively regulates leukocyte chemotaxis [Term] id: GO:0002690 name: positive regulation of leukocyte chemotaxis +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050921 ! positive regulation of chemotaxis @@ -6179,6 +8228,7 @@ relationship: RO:0002213 GO:0030595 ! positively regulates leukocyte chemotaxis [Term] id: GO:0002694 name: regulation of leukocyte activation +def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation @@ -6188,6 +8238,7 @@ relationship: RO:0002211 GO:0045321 ! regulates leukocyte activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation @@ -6198,6 +8249,7 @@ relationship: RO:0002212 GO:0045321 ! negatively regulates leukocyte activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation @@ -6208,6 +8260,7 @@ relationship: RO:0002213 GO:0045321 ! positively regulates leukocyte activation [Term] id: GO:0002697 name: regulation of immune effector process +def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002252 ! regulates immune effector process @@ -6216,6 +8269,7 @@ relationship: RO:0002211 GO:0002252 ! regulates immune effector process [Term] id: GO:0002698 name: negative regulation of immune effector process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation @@ -6225,6 +8279,7 @@ relationship: RO:0002212 GO:0002252 ! negatively regulates immune effector proce [Term] id: GO:0002699 name: positive regulation of immune effector process +def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation @@ -6234,6 +8289,7 @@ relationship: RO:0002213 GO:0002252 ! positively regulates immune effector proce [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response +def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0010468 ! regulation of gene expression intersection_of: GO:0065007 ! biological regulation @@ -6243,6 +8299,7 @@ relationship: RO:0002211 GO:0002440 ! regulates production of molecular mediator [Term] id: GO:0002701 name: negative regulation of production of molecular mediator of immune response +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0010629 ! negative regulation of gene expression @@ -6253,6 +8310,7 @@ relationship: RO:0002212 GO:0002440 ! negatively regulates production of molecul [Term] id: GO:0002702 name: positive regulation of production of molecular mediator of immune response +def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0010628 ! positive regulation of gene expression @@ -6263,6 +8321,7 @@ relationship: RO:0002213 GO:0002440 ! positively regulates production of molecul [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity +def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity @@ -6271,6 +8330,7 @@ relationship: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6280,6 +8340,7 @@ relationship: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated im [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6289,6 +8350,7 @@ relationship: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated im [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity +def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002449 ! regulates lymphocyte mediated immunity @@ -6297,6 +8359,7 @@ relationship: RO:0002211 GO:0002449 ! regulates lymphocyte mediated immunity [Term] id: GO:0002707 name: negative regulation of lymphocyte mediated immunity +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6306,6 +8369,7 @@ relationship: RO:0002212 GO:0002449 ! negatively regulates lymphocyte mediated i [Term] id: GO:0002708 name: positive regulation of lymphocyte mediated immunity +def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6315,6 +8379,7 @@ relationship: RO:0002213 GO:0002449 ! positively regulates lymphocyte mediated i [Term] id: GO:0002709 name: regulation of T cell mediated immunity +def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation @@ -6324,6 +8389,7 @@ relationship: RO:0002211 GO:0002456 ! regulates T cell mediated immunity [Term] id: GO:0002710 name: negative regulation of T cell mediated immunity +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains @@ -6334,6 +8400,7 @@ relationship: RO:0002212 GO:0002456 ! negatively regulates T cell mediated immun [Term] id: GO:0002711 name: positive regulation of T cell mediated immunity +def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains @@ -6344,6 +8411,7 @@ relationship: RO:0002213 GO:0002456 ! positively regulates T cell mediated immun [Term] id: GO:0002718 name: regulation of cytokine production involved in immune response +def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation @@ -6353,6 +8421,7 @@ relationship: RO:0002211 GO:0002367 ! regulates cytokine production involved in [Term] id: GO:0002719 name: negative regulation of cytokine production involved in immune response +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response @@ -6363,6 +8432,7 @@ relationship: RO:0002212 GO:0002367 ! negatively regulates cytokine production i [Term] id: GO:0002720 name: positive regulation of cytokine production involved in immune response +def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response @@ -6373,6 +8443,7 @@ relationship: RO:0002213 GO:0002367 ! positively regulates cytokine production i [Term] id: GO:0002724 name: regulation of T cell cytokine production +def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation @@ -6382,6 +8453,7 @@ relationship: RO:0002211 GO:0002369 ! regulates T cell cytokine production [Term] id: GO:0002725 name: negative regulation of T cell cytokine production +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production @@ -6392,6 +8464,7 @@ relationship: RO:0002212 GO:0002369 ! negatively regulates T cell cytokine produ [Term] id: GO:0002726 name: positive regulation of T cell cytokine production +def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production @@ -6402,6 +8475,7 @@ relationship: RO:0002213 GO:0002369 ! positively regulates T cell cytokine produ [Term] id: GO:0002730 name: regulation of dendritic cell cytokine production +def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation @@ -6411,6 +8485,7 @@ relationship: RO:0002211 GO:0002371 ! regulates dendritic cell cytokine producti [Term] id: GO:0002731 name: negative regulation of dendritic cell cytokine production +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production @@ -6421,6 +8496,7 @@ relationship: RO:0002212 GO:0002371 ! negatively regulates dendritic cell cytoki [Term] id: GO:0002732 name: positive regulation of dendritic cell cytokine production +def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production @@ -6431,6 +8507,7 @@ relationship: RO:0002213 GO:0002371 ! positively regulates dendritic cell cytoki [Term] id: GO:0002733 name: regulation of myeloid dendritic cell cytokine production +def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6440,6 +8517,7 @@ relationship: RO:0002211 GO:0002372 ! regulates myeloid dendritic cell cytokine [Term] id: GO:0002734 name: negative regulation of myeloid dendritic cell cytokine production +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity @@ -6450,6 +8528,7 @@ relationship: RO:0002212 GO:0002372 ! negatively regulates myeloid dendritic cel [Term] id: GO:0002735 name: positive regulation of myeloid dendritic cell cytokine production +def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity @@ -6461,6 +8540,7 @@ relationship: RO:0002213 GO:0002372 ! positively regulates myeloid dendritic cel [Term] id: GO:0002761 name: regulation of myeloid leukocyte differentiation +def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation @@ -6470,6 +8550,7 @@ relationship: RO:0002211 GO:0002573 ! regulates myeloid leukocyte differentiatio [Term] id: GO:0002762 name: negative regulation of myeloid leukocyte differentiation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:1902106 ! negative regulation of leukocyte differentiation @@ -6480,6 +8561,7 @@ relationship: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte dif [Term] id: GO:0002763 name: positive regulation of myeloid leukocyte differentiation +def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:1902107 ! positive regulation of leukocyte differentiation @@ -6490,6 +8572,7 @@ relationship: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte dif [Term] id: GO:0002790 name: peptide secretion +def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion intersection_of: GO:0046903 ! secretion @@ -6498,6 +8581,7 @@ intersection_of: RO:0004009 CHEBI:60466 ! has primary input [Term] id: GO:0002791 name: regulation of peptide secretion +def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0065007 ! biological regulation @@ -6507,6 +8591,7 @@ relationship: RO:0002211 GO:0002790 ! regulates peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion intersection_of: GO:0065007 ! biological regulation @@ -6516,6 +8601,7 @@ relationship: RO:0002212 GO:0002790 ! negatively regulates peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion +def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion intersection_of: GO:0065007 ! biological regulation @@ -6525,6 +8611,7 @@ relationship: RO:0002213 GO:0002790 ! positively regulates peptide secretion [Term] id: GO:0002819 name: regulation of adaptive immune response +def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002250 ! regulates adaptive immune response @@ -6533,6 +8620,7 @@ relationship: RO:0002211 GO:0002250 ! regulates adaptive immune response [Term] id: GO:0002820 name: negative regulation of adaptive immune response +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation @@ -6542,6 +8630,7 @@ relationship: RO:0002212 GO:0002250 ! negatively regulates adaptive immune respo [Term] id: GO:0002821 name: positive regulation of adaptive immune response +def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation @@ -6551,6 +8640,7 @@ relationship: RO:0002213 GO:0002250 ! positively regulates adaptive immune respo [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002819 ! regulation of adaptive immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002460 ! regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains @@ -6561,6 +8651,7 @@ relationship: RO:0002211 GO:0002460 ! regulates adaptive immune response based o [Term] id: GO:0002823 name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation @@ -6570,6 +8661,7 @@ relationship: RO:0002212 GO:0002460 ! negatively regulates adaptive immune respo [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation @@ -6579,6 +8671,8 @@ relationship: RO:0002213 GO:0002460 ! positively regulates adaptive immune respo [Term] id: GO:0002831 name: regulation of response to biotic stimulus +def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009607 ! regulates response to biotic stimulus @@ -6587,6 +8681,8 @@ relationship: RO:0002211 GO:0009607 ! regulates response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation @@ -6596,6 +8692,8 @@ relationship: RO:0002212 GO:0009607 ! negatively regulates response to biotic st [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus +def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation @@ -6605,6 +8703,7 @@ relationship: RO:0002213 GO:0009607 ! positively regulates response to biotic st [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity +def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immunity @@ -6613,6 +8712,7 @@ relationship: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immun [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6622,6 +8722,7 @@ relationship: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte med [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity +def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6631,6 +8732,7 @@ relationship: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte med [Term] id: GO:0002932 name: tendon sheath development +def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000304 ! results in development of tendon sheath @@ -6640,11 +8742,13 @@ relationship: RO:0002296 UBERON:0000304 ! results in development of tendon sheat [Term] id: GO:0003002 name: regionalization +def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0003006 name: developmental process involved in reproduction +def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process intersection_of: GO:0022414 ! reproductive process @@ -6653,6 +8757,7 @@ intersection_of: GO:0032502 ! developmental process [Term] id: GO:0003007 name: heart morphogenesis +def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ @@ -6662,11 +8767,13 @@ relationship: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary ci [Term] id: GO:0003008 name: system process +def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003009 name: skeletal muscle contraction +def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0006941 ! striated muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue @@ -6676,33 +8783,46 @@ relationship: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue [Term] id: GO:0003012 name: muscle system process +def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] is_a: GO:0003008 ! system process [Term] id: GO:0003013 name: circulatory system process +def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] +xref: Wikipedia:Circulatory_system +is_a: GO:0003008 ! system process + +[Term] +id: GO:0003014 +name: renal system process +def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process +def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003016 name: respiratory system process +def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] is_a: GO:0003008 ! system process relationship: BFO:0000050 GO:0007585 ! part of respiratory gaseous exchange by respiratory system [Term] id: GO:0003032 name: detection of oxygen +def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0003131 name: mesodermal-endodermal cell signaling +def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000222 ! has start location mesodermal cell @@ -6713,6 +8833,7 @@ relationship: RO:0002232 CL:0000223 ! has end location endodermal cell [Term] id: GO:0003133 name: endodermal-mesodermal cell signaling +def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000223 ! has start location endodermal cell @@ -6723,6 +8844,7 @@ relationship: RO:0002232 CL:0000222 ! has end location mesodermal cell [Term] id: GO:0003142 name: cardiogenic plate morphogenesis +def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate @@ -6732,6 +8854,7 @@ relationship: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogeni [Term] id: GO:0003143 name: embryonic heart tube morphogenesis +def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -6744,6 +8867,7 @@ relationship: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube [Term] id: GO:0003144 name: embryonic heart tube formation +def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004141 ! results in formation of heart tube @@ -6753,11 +8877,13 @@ relationship: RO:0002297 UBERON:0004141 ! results in formation of heart tube [Term] id: GO:0003145 name: embryonic heart tube formation via epithelial folding +def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] is_a: GO:0003144 ! embryonic heart tube formation [Term] id: GO:0003147 name: neural crest cell migration involved in heart formation +def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060974 ! cell migration involved in heart formation intersection_of: GO:0001755 ! neural crest cell migration @@ -6767,6 +8893,7 @@ relationship: BFO:0000050 GO:0061308 ! part of cardiac neural crest cell develop [Term] id: GO:0003148 name: outflow tract septum morphogenesis +def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum @@ -6776,6 +8903,7 @@ relationship: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tr [Term] id: GO:0003149 name: membranous septum morphogenesis +def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part @@ -6785,6 +8913,7 @@ relationship: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventr [Term] id: GO:0003150 name: muscular septum morphogenesis +def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part @@ -6794,6 +8923,7 @@ relationship: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventr [Term] id: GO:0003151 name: outflow tract morphogenesis +def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract @@ -6803,6 +8933,7 @@ relationship: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tr [Term] id: GO:0003152 name: morphogenesis of an epithelial fold involved in embryonic heart tube formation +def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0060571 ! morphogenesis of an epithelial fold @@ -6812,6 +8943,7 @@ relationship: BFO:0000050 GO:0003145 ! part of embryonic heart tube formation vi [Term] id: GO:0003156 name: regulation of animal organ formation +def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048645 ! regulates animal organ formation @@ -6820,6 +8952,7 @@ relationship: RO:0002211 GO:0048645 ! regulates animal organ formation [Term] id: GO:0003157 name: endocardium development +def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002165 ! results in development of endocardium @@ -6829,6 +8962,7 @@ relationship: RO:0002296 UBERON:0002165 ! results in development of endocardium [Term] id: GO:0003158 name: endothelium development +def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001986 ! results in development of endothelium @@ -6837,6 +8971,7 @@ relationship: RO:0002296 UBERON:0001986 ! results in development of endothelium [Term] id: GO:0003159 name: morphogenesis of an endothelium +def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium @@ -6846,6 +8981,7 @@ relationship: RO:0002298 UBERON:0001986 ! results in morphogenesis of endotheliu [Term] id: GO:0003160 name: endocardium morphogenesis +def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium @@ -6855,6 +8991,7 @@ relationship: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardiu [Term] id: GO:0003161 name: cardiac conduction system development +def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart @@ -6863,6 +9000,7 @@ relationship: RO:0002296 UBERON:0002350 ! results in development of conducting s [Term] id: GO:0003162 name: atrioventricular node development +def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node @@ -6872,6 +9010,7 @@ relationship: RO:0002296 UBERON:0002352 ! results in development of atrioventric [Term] id: GO:0003163 name: sinoatrial node development +def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] is_a: GO:0003228 ! atrial cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node @@ -6881,6 +9020,7 @@ relationship: RO:0002296 UBERON:0002351 ! results in development of sinoatrial n [Term] id: GO:0003164 name: His-Purkinje system development +def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system @@ -6890,6 +9030,7 @@ relationship: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje [Term] id: GO:0003165 name: Purkinje myocyte development +def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber @@ -6899,6 +9040,7 @@ relationship: RO:0002296 UBERON:0002354 ! results in development of cardiac Purk [Term] id: GO:0003168 name: Purkinje myocyte differentiation +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0060932 ! His-Purkinje system cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte @@ -6908,6 +9050,7 @@ relationship: RO:0002315 CL:0002068 ! results in acquisition of features of Purk [Term] id: GO:0003169 name: coronary vein morphogenesis +def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] is_a: GO:0048845 ! venous blood vessel morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -6917,6 +9060,7 @@ relationship: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac ve [Term] id: GO:0003197 name: endocardial cushion development +def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion @@ -6926,6 +9070,7 @@ relationship: RO:0002296 UBERON:0002062 ! results in development of endocardial [Term] id: GO:0003203 name: endocardial cushion morphogenesis +def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion @@ -6936,6 +9081,7 @@ relationship: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardia [Term] id: GO:0003204 name: cardiac skeleton development +def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton @@ -6945,6 +9091,7 @@ relationship: RO:0002296 UBERON:0004292 ! results in development of cardiac skel [Term] id: GO:0003205 name: cardiac chamber development +def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber @@ -6954,6 +9101,7 @@ relationship: RO:0002296 UBERON:0004151 ! results in development of cardiac cham [Term] id: GO:0003206 name: cardiac chamber morphogenesis +def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber @@ -6964,6 +9112,7 @@ relationship: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac ch [Term] id: GO:0003207 name: cardiac chamber formation +def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004151 ! results in formation of cardiac chamber @@ -6973,6 +9122,7 @@ relationship: RO:0002297 UBERON:0004151 ! results in formation of cardiac chambe [Term] id: GO:0003208 name: cardiac ventricle morphogenesis +def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle @@ -6982,6 +9132,7 @@ relationship: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ve [Term] id: GO:0003209 name: cardiac atrium morphogenesis +def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac atrium @@ -6991,6 +9142,7 @@ relationship: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac at [Term] id: GO:0003210 name: cardiac atrium formation +def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002081 ! results in formation of cardiac atrium @@ -7000,6 +9152,7 @@ relationship: RO:0002297 UBERON:0002081 ! results in formation of cardiac atrium [Term] id: GO:0003211 name: cardiac ventricle formation +def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002082 ! results in formation of cardiac ventricle @@ -7009,6 +9162,7 @@ relationship: RO:0002297 UBERON:0002082 ! results in formation of cardiac ventri [Term] id: GO:0003212 name: cardiac left atrium morphogenesis +def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardiac atrium @@ -7017,6 +9171,7 @@ relationship: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardi [Term] id: GO:0003213 name: cardiac right atrium morphogenesis +def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002078 ! results in morphogenesis of right cardiac atrium @@ -7025,6 +9180,7 @@ relationship: RO:0002298 UBERON:0002078 ! results in morphogenesis of right card [Term] id: GO:0003214 name: cardiac left ventricle morphogenesis +def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left ventricle @@ -7033,6 +9189,7 @@ relationship: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left [Term] id: GO:0003215 name: cardiac right ventricle morphogenesis +def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart right ventricle @@ -7041,6 +9198,7 @@ relationship: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart righ [Term] id: GO:0003216 name: cardiac left atrium formation +def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002079 ! results in formation of left cardiac atrium @@ -7050,6 +9208,7 @@ relationship: RO:0002297 UBERON:0002079 ! results in formation of left cardiac a [Term] id: GO:0003217 name: cardiac right atrium formation +def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002078 ! results in formation of right cardiac atrium @@ -7059,6 +9218,7 @@ relationship: RO:0002297 UBERON:0002078 ! results in formation of right cardiac [Term] id: GO:0003218 name: cardiac left ventricle formation +def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002084 ! results in formation of heart left ventricle @@ -7068,6 +9228,7 @@ relationship: RO:0002297 UBERON:0002084 ! results in formation of heart left ven [Term] id: GO:0003219 name: cardiac right ventricle formation +def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002080 ! results in formation of heart right ventricle @@ -7077,6 +9238,7 @@ relationship: RO:0002297 UBERON:0002080 ! results in formation of heart right ve [Term] id: GO:0003220 name: left ventricular cardiac muscle tissue morphogenesis +def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac muscle of left ventricle @@ -7086,15 +9248,47 @@ relationship: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac mu [Term] id: GO:0003221 name: right ventricular cardiac muscle tissue morphogenesis +def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle relationship: BFO:0000050 GO:0003215 ! part of cardiac right ventricle morphogenesis relationship: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle +[Term] +id: GO:0003222 +name: ventricular trabecula myocardium morphogenesis +def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] +is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis +is_a: GO:0061384 ! heart trabecula morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: RO:0002298 UBERON:0004126 ! results in morphogenesis of trabecular layer of ventricle +relationship: RO:0002298 UBERON:0004126 ! results in morphogenesis of trabecular layer of ventricle + +[Term] +id: GO:0003225 +name: left ventricular trabecular myocardium morphogenesis +def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart] +is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis +is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: RO:0002298 UBERON:0005064 ! results in morphogenesis of left ventricular trabecular myocardium +relationship: RO:0002298 UBERON:0005064 ! results in morphogenesis of left ventricular trabecular myocardium + +[Term] +id: GO:0003227 +name: right ventricular trabecular myocardium morphogenesis +def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart] +is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis +is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: RO:0002298 UBERON:0005066 ! results in morphogenesis of right ventricular trabecular myocardium +relationship: RO:0002298 UBERON:0005066 ! results in morphogenesis of right ventricular trabecular myocardium + [Term] id: GO:0003228 name: atrial cardiac muscle tissue development +def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004490 ! results in development of cardiac muscle tissue of atrium @@ -7103,6 +9297,7 @@ relationship: RO:0002296 UBERON:0004490 ! results in development of cardiac musc [Term] id: GO:0003229 name: ventricular cardiac muscle tissue development +def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0018649 ! results in development of cardiac muscle tissue of ventricle @@ -7111,6 +9306,7 @@ relationship: RO:0002296 UBERON:0018649 ! results in development of cardiac musc [Term] id: GO:0003230 name: cardiac atrium development +def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002081 ! results in development of cardiac atrium @@ -7119,6 +9315,7 @@ relationship: RO:0002296 UBERON:0002081 ! results in development of cardiac atri [Term] id: GO:0003231 name: cardiac ventricle development +def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002082 ! results in development of cardiac ventricle @@ -7127,6 +9324,7 @@ relationship: RO:0002296 UBERON:0002082 ! results in development of cardiac vent [Term] id: GO:0003235 name: sinus venosus development +def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002063 ! results in development of sinus venosus @@ -7135,6 +9333,7 @@ relationship: RO:0002296 UBERON:0002063 ! results in development of sinus venosu [Term] id: GO:0003236 name: sinus venosus morphogenesis +def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus venosus @@ -7144,6 +9343,7 @@ relationship: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus veno [Term] id: GO:0003237 name: sinus venosus formation +def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002063 ! results in formation of sinus venosus @@ -7153,6 +9353,7 @@ relationship: RO:0002297 UBERON:0002063 ! results in formation of sinus venosus [Term] id: GO:0003241 name: growth involved in heart morphogenesis +def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis intersection_of: GO:0040007 ! growth intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis @@ -7162,6 +9363,7 @@ relationship: BFO:0000050 GO:0060419 ! part of heart growth [Term] id: GO:0003245 name: cardiac muscle tissue growth involved in heart morphogenesis +def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0055017 ! cardiac muscle tissue growth intersection_of: GO:0055017 ! cardiac muscle tissue growth @@ -7171,6 +9373,7 @@ relationship: BFO:0000050 GO:0055008 ! part of cardiac muscle tissue morphogenes [Term] id: GO:0003248 name: heart capillary growth +def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0006966 ! results in growth of coronary capillary @@ -7181,6 +9384,7 @@ relationship: RO:0002343 UBERON:0006966 ! results in growth of coronary capillar [Term] id: GO:0003253 name: cardiac neural crest cell migration involved in outflow tract morphogenesis +def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0001755 ! neural crest cell migration @@ -7190,6 +9394,7 @@ relationship: BFO:0000050 GO:0061309 ! part of cardiac neural crest cell develop [Term] id: GO:0003260 name: cardioblast migration +def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0060974 ! cell migration involved in heart formation intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0002664 ! results in movement of cardioblast @@ -7198,6 +9403,7 @@ relationship: RO:0002565 CL:0002664 ! results in movement of cardioblast [Term] id: GO:0003272 name: endocardial cushion formation +def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002062 ! results in formation of endocardial cushion @@ -7207,6 +9413,7 @@ relationship: RO:0002297 UBERON:0002062 ! results in formation of endocardial cu [Term] id: GO:0003273 name: cell migration involved in endocardial cushion formation +def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0003272 ! part of endocardial cushion formation @@ -7215,6 +9422,7 @@ relationship: BFO:0000050 GO:0003272 ! part of endocardial cushion formation [Term] id: GO:0003275 name: apoptotic process involved in outflow tract morphogenesis +def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis @@ -7223,6 +9431,7 @@ relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis [Term] id: GO:0003277 name: apoptotic process involved in endocardial cushion morphogenesis +def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis @@ -7231,6 +9440,7 @@ relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis [Term] id: GO:0003278 name: apoptotic process involved in heart morphogenesis +def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis @@ -7239,6 +9449,7 @@ relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis [Term] id: GO:0003279 name: cardiac septum development +def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002099 ! results in development of cardiac septum @@ -7248,6 +9459,7 @@ relationship: RO:0002296 UBERON:0002099 ! results in development of cardiac sept [Term] id: GO:0003281 name: ventricular septum development +def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002094 ! results in development of interventricular septum @@ -7257,6 +9469,7 @@ relationship: RO:0002296 UBERON:0002094 ! results in development of interventric [Term] id: GO:0003283 name: atrial septum development +def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002085 ! results in development of interatrial septum @@ -7266,6 +9479,7 @@ relationship: RO:0002296 UBERON:0002085 ! results in development of interatrial [Term] id: GO:0003292 name: cardiac septum cell differentiation +def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000022 ! results in acquisition of features of cardiac septum cell @@ -7275,23 +9489,67 @@ relationship: RO:0002315 CL:2000022 ! results in acquisition of features of card [Term] id: GO:0003298 name: physiological muscle hypertrophy +def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] is_a: GO:0014896 ! muscle hypertrophy [Term] id: GO:0003300 name: cardiac muscle hypertrophy +def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] is_a: GO:0014897 ! striated muscle hypertrophy [Term] id: GO:0003301 name: physiological cardiac muscle hypertrophy +def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0003298 ! physiological muscle hypertrophy is_a: GO:0003300 ! cardiac muscle hypertrophy relationship: BFO:0000050 GO:0055017 ! part of cardiac muscle tissue growth +[Term] +id: GO:0003309 +name: type B pancreatic cell differentiation +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: RO:0002315 CL:0000169 ! results in acquisition of features of type B pancreatic cell +relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development +relationship: RO:0002315 CL:0000169 ! results in acquisition of features of type B pancreatic cell + +[Term] +id: GO:0003310 +name: pancreatic A cell differentiation +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: RO:0002315 CL:0000171 ! results in acquisition of features of pancreatic A cell +relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development +relationship: RO:0002315 CL:0000171 ! results in acquisition of features of pancreatic A cell + +[Term] +id: GO:0003311 +name: pancreatic D cell differentiation +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: RO:0002315 CL:0000173 ! results in acquisition of features of pancreatic D cell +relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development +relationship: RO:0002315 CL:0000173 ! results in acquisition of features of pancreatic D cell + +[Term] +id: GO:0003312 +name: pancreatic PP cell differentiation +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: RO:0002315 CL:0002275 ! results in acquisition of features of pancreatic PP cell +relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development +relationship: RO:0002315 CL:0002275 ! results in acquisition of features of pancreatic PP cell + [Term] id: GO:0003313 name: heart rudiment development +def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004291 ! results in development of heart rudiment @@ -7301,6 +9559,7 @@ relationship: RO:0002296 UBERON:0004291 ! results in development of heart rudime [Term] id: GO:0003314 name: heart rudiment morphogenesis +def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -7311,15 +9570,58 @@ relationship: RO:0002298 UBERON:0004291 ! results in morphogenesis of heart rudi [Term] id: GO:0003315 name: heart rudiment formation +def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004291 ! results in formation of heart rudiment relationship: BFO:0000050 GO:0003314 ! part of heart rudiment morphogenesis relationship: RO:0002297 UBERON:0004291 ! results in formation of heart rudiment +[Term] +id: GO:0003322 +name: pancreatic A cell development +def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0032502 ! developmental process +intersection_of: RO:0002296 CL:0000171 ! results in development of pancreatic A cell +relationship: BFO:0000050 GO:0003310 ! part of pancreatic A cell differentiation +relationship: RO:0002296 CL:0000171 ! results in development of pancreatic A cell + +[Term] +id: GO:0003323 +name: type B pancreatic cell development +def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0032502 ! developmental process +intersection_of: RO:0002296 CL:0000169 ! results in development of type B pancreatic cell +relationship: BFO:0000050 GO:0003309 ! part of type B pancreatic cell differentiation +relationship: RO:0002296 CL:0000169 ! results in development of type B pancreatic cell + +[Term] +id: GO:0003324 +name: pancreatic D cell development +def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0032502 ! developmental process +intersection_of: RO:0002296 CL:0000173 ! results in development of pancreatic D cell +relationship: BFO:0000050 GO:0003311 ! part of pancreatic D cell differentiation +relationship: RO:0002296 CL:0000173 ! results in development of pancreatic D cell + +[Term] +id: GO:0003325 +name: pancreatic PP cell development +def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0048468 ! cell development +intersection_of: RO:0002296 CL:0002275 ! results in development of pancreatic PP cell +relationship: BFO:0000050 GO:0003312 ! part of pancreatic PP cell differentiation +relationship: RO:0002296 CL:0002275 ! results in development of pancreatic PP cell + [Term] id: GO:0003341 name: cilium movement +def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. is_a: GO:0007018 ! microtubule-based movement intersection_of: GO:0007018 ! microtubule-based movement intersection_of: RO:0002565 GO:0005929 ! results in movement of cilium @@ -7331,6 +9633,7 @@ relationship: RO:0002565 GO:0005929 ! results in movement of cilium [Term] id: GO:0003342 name: proepicardium development +def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004160 ! results in development of proepicardium @@ -7340,6 +9643,7 @@ relationship: RO:0002296 UBERON:0004160 ! results in development of proepicardiu [Term] id: GO:0003343 name: septum transversum development +def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004161 ! results in development of septum transversum @@ -7348,6 +9652,7 @@ relationship: RO:0002296 UBERON:0004161 ! results in development of septum trans [Term] id: GO:0003344 name: pericardium morphogenesis +def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -7358,6 +9663,7 @@ relationship: RO:0002298 UBERON:0002407 ! results in morphogenesis of pericardiu [Term] id: GO:0003348 name: cardiac endothelial cell differentiation +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0045446 ! endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation @@ -7367,6 +9673,8 @@ relationship: RO:0002315 CL:0010008 ! results in acquisition of features of card [Term] id: GO:0003352 name: regulation of cilium movement +def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003341 ! regulates cilium movement @@ -7375,6 +9683,8 @@ relationship: RO:0002211 GO:0003341 ! regulates cilium movement [Term] id: GO:0003353 name: positive regulation of cilium movement +def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation @@ -7384,6 +9694,8 @@ relationship: RO:0002213 GO:0003341 ! positively regulates cilium movement [Term] id: GO:0003354 name: negative regulation of cilium movement +def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation @@ -7393,6 +9705,7 @@ relationship: RO:0002212 GO:0003341 ! negatively regulates cilium movement [Term] id: GO:0003360 name: brainstem development +def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002298 ! results in development of brainstem @@ -7401,6 +9714,7 @@ relationship: RO:0002296 UBERON:0002298 ! results in development of brainstem [Term] id: GO:0003365 name: establishment of cell polarity involved in ameboidal cell migration +def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration @@ -7409,6 +9723,7 @@ relationship: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration [Term] id: GO:0003371 name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration @@ -7417,6 +9732,7 @@ relationship: BFO:0000050 GO:0003365 ! part of establishment of cell polarity in [Term] id: GO:0003379 name: establishment of cell polarity involved in gastrulation cell migration +def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000050 GO:0042074 ! part of cell migration involved in gastrulation @@ -7425,6 +9741,7 @@ relationship: BFO:0000050 GO:0042074 ! part of cell migration involved in gastru [Term] id: GO:0003380 name: establishment or maintenance of cytoskeleton polarity involved in gastrulation +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation @@ -7433,6 +9750,7 @@ relationship: BFO:0000050 GO:0003379 ! part of establishment of cell polarity in [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation +def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0003382 ! epithelial cell morphogenesis intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation @@ -7441,6 +9759,7 @@ relationship: BFO:0000050 GO:0007369 ! part of gastrulation [Term] id: GO:0003382 name: epithelial cell morphogenesis +def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell @@ -7450,6 +9769,7 @@ relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell [Term] id: GO:0003403 name: optic vesicle formation +def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004128 ! results in formation of optic vesicle @@ -7460,6 +9780,7 @@ relationship: RO:0002297 UBERON:0004128 ! results in formation of optic vesicle [Term] id: GO:0003404 name: optic vesicle morphogenesis +def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -7470,6 +9791,7 @@ relationship: RO:0002298 UBERON:0004128 ! results in morphogenesis of optic vesi [Term] id: GO:0003407 name: neural retina development +def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003902 ! results in development of retinal neural layer @@ -7479,6 +9801,7 @@ relationship: RO:0002296 UBERON:0003902 ! results in development of retinal neur [Term] id: GO:0003411 name: cell motility involved in camera-type eye morphogenesis +def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility intersection_of: GO:0048870 ! cell motility intersection_of: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis @@ -7487,6 +9810,7 @@ relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis [Term] id: GO:0003413 name: chondrocyte differentiation involved in endochondral bone morphogenesis +def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002062 ! chondrocyte differentiation intersection_of: GO:0002062 ! chondrocyte differentiation intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis @@ -7495,6 +9819,7 @@ relationship: BFO:0000050 GO:0060351 ! part of cartilage development involved in [Term] id: GO:0003414 name: chondrocyte morphogenesis involved in endochondral bone morphogenesis +def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090171 ! chondrocyte morphogenesis intersection_of: GO:0090171 ! chondrocyte morphogenesis intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis @@ -7503,6 +9828,7 @@ relationship: BFO:0000050 GO:0003433 ! part of chondrocyte development involved [Term] id: GO:0003416 name: endochondral bone growth +def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098868 ! bone growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone @@ -7511,31 +9837,135 @@ relationship: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone [Term] id: GO:0003433 name: chondrocyte development involved in endochondral bone morphogenesis +def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002063 ! chondrocyte development intersection_of: GO:0002063 ! chondrocyte development intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis relationship: BFO:0000050 GO:0003413 ! part of chondrocyte differentiation involved in endochondral bone morphogenesis +[Term] +id: GO:0003674 +name: molecular_function +def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt] +comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. +is_a: BFO:0000015 +disjoint_from: GO:0005575 ! cellular_component +disjoint_from: GO:0008150 ! biological_process + +[Term] +id: GO:0003824 +name: catalytic activity +def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] +xref: Wikipedia:Enzyme +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0004518 +name: nuclease activity +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] +comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0004536 +name: DNA nuclease activity +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] +xref: Reactome:R-HSA-211247 "Cleavage of DNA by DFF40" +xref: Reactome:R-HSA-5685994 "Long-range resection of DNA DSBs by EXO1 or DNA2" +xref: Reactome:R-HSA-6785986 "DNA nucleases unhook the interstrand crosslink (ICL)" +is_a: GO:0004518 ! nuclease activity +is_a: GO:0140097 ! catalytic activity, acting on DNA +relationship: BFO:0000050 GO:0006259 ! part of DNA metabolic process + +[Term] +id: GO:0005215 +name: transporter activity +def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells." [GOC:ai, GOC:dgf] +comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0005275 +name: amine transmembrane transporter activity +def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: RO:0004009 CHEBI:32952 ! has primary input +relationship: BFO:0000050 GO:0015837 ! part of amine transport +relationship: RO:0004009 CHEBI:32952 ! has primary input + +[Term] +id: GO:0005319 +name: lipid transporter activity +def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] +xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux" +xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx" +xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" +xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region" +xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region" +xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane" +xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL" +is_a: GO:0005215 ! transporter activity +intersection_of: GO:0005215 ! transporter activity +intersection_of: RO:0004009 CHEBI:18059 ! has primary input +relationship: BFO:0000050 GO:0006869 ! part of lipid transport +relationship: RO:0004009 CHEBI:18059 ! has primary input + +[Term] +id: GO:0005342 +name: organic acid transmembrane transporter activity +def: "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage." [ISBN:0198506732] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: RO:0004009 CHEBI:64709 ! has primary input +relationship: BFO:0000050 GO:1903825 ! part of organic acid transmembrane transport +relationship: RO:0004009 CHEBI:64709 ! has primary input + +[Term] +id: GO:0005355 +name: glucose transmembrane transporter activity +def: "Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-499981 "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2" +xref: Reactome:R-HSA-5653873 "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen" +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: RO:0004009 CHEBI:4167 ! has primary input +relationship: BFO:0000050 GO:1904659 ! part of glucose transmembrane transport +relationship: RO:0004009 CHEBI:4167 ! has primary input + [Term] id: GO:0005575 name: cellular_component +def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt] +comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. +xref: NIF_Subcellular:sao1337158144 is_a: BFO:0000040 disjoint_from: GO:0008150 ! biological_process [Term] id: GO:0005576 name: extracellular region +def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] +comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. +xref: Wikipedia:Extracellular is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0005577 name: fibrinogen complex +def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] is_a: GO:0032991 ! protein-containing complex relationship: BFO:0000050 GO:0005615 ! part of extracellular space [Term] id: GO:0005581 name: collagen trimer +def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] +xref: Wikipedia:Collagen is_a: GO:0032991 ! protein-containing complex relationship: RO:0002160 NCBITaxon:33208 ! Metazoa relationship: RO:0002162 NCBITaxon:33208 {all_only="true"} ! Metazoa @@ -7543,6 +9973,7 @@ relationship: RO:0002162 NCBITaxon:33208 {all_only="true"} ! Metazoa [Term] id: GO:0005583 name: fibrillar collagen trimer +def: "Any triple helical collagen trimer that forms fibrils." [GOC:mah, ISBN:0721639976, PMID:21421911] is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: BFO:0000050 GO:0098643 ! part of banded collagen fibril @@ -7552,34 +9983,49 @@ relationship: BFO:0000050 GO:0098643 ! part of banded collagen fibril [Term] id: GO:0005585 name: collagen type II trimer +def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] +xref: Wikipedia:Collagen_type_II is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005587 name: collagen type IV trimer +def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [ISBN:0721639976, PMID:19693541, PMID:21421911] +xref: Wikipedia:Collagen_type_IV is_a: GO:0098642 ! network-forming collagen trimer is_a: GO:0098651 ! basement membrane collagen trimer [Term] id: GO:0005604 name: basement membrane +def: "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934] +comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. +xref: Wikipedia:Basement_membrane is_a: GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0005615 name: extracellular space +def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] +comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. +xref: NIF_Subcellular:sao1425028079 is_a: GO:0110165 ! cellular anatomical entity relationship: BFO:0000050 GO:0005576 ! part of extracellular region [Term] id: GO:0005622 name: intracellular anatomical structure +def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] +xref: Wikipedia:Intracellular is_a: GO:0110165 ! cellular anatomical entity relationship: BFO:0000050 CL:0000000 ! part of cell [Term] id: GO:0005634 name: nucleus +def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] +xref: NIF_Subcellular:sao1702920020 +xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle disjoint_from: GO:0005737 ! cytoplasm relationship: RO:0002160 NCBITaxon:2759 ! Eukaryota @@ -7588,6 +10034,8 @@ relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! Eukaryota [Term] id: GO:0005635 name: nuclear envelope +def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] +xref: Wikipedia:Nuclear_envelope is_a: GO:0031967 ! organelle envelope relationship: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0012505 ! part of endomembrane system @@ -7595,6 +10043,8 @@ relationship: BFO:0000050 GO:0012505 ! part of endomembrane system [Term] id: GO:0005640 name: nuclear outer membrane +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] +xref: NIF_Subcellular:sao1617136075 is_a: GO:0031965 ! nuclear membrane is_a: GO:0031968 ! organelle outer membrane intersection_of: GO:0016020 ! membrane @@ -7605,28 +10055,40 @@ relationship: RO:0002007 GO:0005634 ! bounding layer of nucleus [Term] id: GO:0005694 name: chromosome +def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] +comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. +xref: Wikipedia:Chromosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005730 name: nucleolus +def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] +xref: NIF_Subcellular:sao1820400233 +xref: Wikipedia:Nucleolus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: BFO:0000050 GO:0031981 ! part of nuclear lumen [Term] id: GO:0005737 name: cytoplasm +def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] +xref: Wikipedia:Cytoplasm is_a: GO:0110165 ! cellular anatomical entity relationship: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure [Term] id: GO:0005764 name: lysosome +def: "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] +xref: NIF_Subcellular:sao585356902 +xref: Wikipedia:Lysosome is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0005765 name: lysosomal membrane +def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] is_a: GO:0098852 ! lytic vacuole membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005764 ! bounding layer of lysosome @@ -7636,17 +10098,22 @@ relationship: RO:0002007 GO:0005764 ! bounding layer of lysosome [Term] id: GO:0005766 name: primary lysosome +def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] +xref: NIF_Subcellular:sao1140587416 is_a: GO:0005764 ! lysosome [Term] id: GO:0005773 name: vacuole +def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] +xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0005774 name: vacuolar membrane +def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005773 ! bounding layer of vacuole @@ -7656,6 +10123,7 @@ relationship: RO:0002007 GO:0005773 ! bounding layer of vacuole [Term] id: GO:0005775 name: vacuolar lumen +def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: BFO:0000050 GO:0005773 ! part of vacuole @@ -7664,6 +10132,10 @@ relationship: BFO:0000050 GO:0005773 ! part of vacuole [Term] id: GO:0005794 name: Golgi apparatus +def: "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732] +comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. +xref: NIF_Subcellular:sao451912436 +xref: Wikipedia:Golgi_apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0012505 ! part of endomembrane system @@ -7673,11 +10145,17 @@ relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! Eukaryota [Term] id: GO:0005798 name: Golgi-associated vesicle +def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] +comment: Note that this definition includes vesicles that are transiently associated with the Golgi. +xref: NIF_Subcellular:sao819927218 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0005840 name: ribosome +def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] +xref: NIF_Subcellular:sao1429207766 +xref: Wikipedia:Ribosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: BFO:0000051 CHEBI:33697 ! has part relationship: BFO:0000051 PR:000000001 ! has part @@ -7686,17 +10164,23 @@ relationship: RO:0002216 GO:0006412 ! capable of part of translation [Term] id: GO:0005856 name: cytoskeleton +def: "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] +xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005874 name: microtubule +def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] +xref: NIF_Subcellular:sao1846835077 +xref: Wikipedia:Microtubule is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: BFO:0000050 GO:0015630 ! part of microtubule cytoskeleton [Term] id: GO:0005879 name: axonemal microtubule +def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194] is_a: GO:0005881 ! cytoplasmic microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005930 ! part of axoneme @@ -7705,6 +10189,7 @@ relationship: BFO:0000050 GO:0005930 ! part of axoneme [Term] id: GO:0005880 name: nuclear microtubule +def: "Any microtubule in the nucleus of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005634 ! part of nucleus @@ -7713,6 +10198,7 @@ relationship: BFO:0000050 GO:0005634 ! part of nucleus [Term] id: GO:0005881 name: cytoplasmic microtubule +def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm @@ -7721,18 +10207,29 @@ relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0005884 name: actin filament +def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] +xref: FMA:63850 +xref: NIF_Subcellular:sao1588493326 +xref: Wikipedia:Actin is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: BFO:0000050 GO:0015629 ! part of actin cytoskeleton [Term] id: GO:0005886 name: plasma membrane +def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] +xref: NIF_Subcellular:sao1663586795 +xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: BFO:0000050 GO:0071944 ! part of cell periphery [Term] id: GO:0005902 name: microvillus +def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194] +comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. +xref: NIF_Subcellular:sao671419673 +xref: Wikipedia:Microvillus is_a: GO:0098858 ! actin-based cell projection relationship: BFO:0000050 CL:0000066 ! part of epithelial cell relationship: BFO:0000051 GO:0032432 ! has part actin filament bundle @@ -7740,11 +10237,18 @@ relationship: BFO:0000051 GO:0032432 ! has part actin filament bundle [Term] id: GO:0005911 name: cell-cell junction +def: "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] +xref: NIF_Subcellular:sao1922892319 is_a: GO:0070161 ! anchoring junction [Term] id: GO:0005929 name: cilium +def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. +xref: FMA:67181 +xref: NIF_Subcellular:sao787716553 +xref: Wikipedia:Cilium is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: BFO:0000051 GO:0030990 ! has part intraciliary transport particle @@ -7754,6 +10258,9 @@ relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! Eukaryota [Term] id: GO:0005930 name: axoneme +def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. +xref: Wikipedia:Axoneme is_a: GO:0110165 ! cellular anatomical entity relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton relationship: BFO:0000050 GO:0097014 ! part of ciliary plasm @@ -7762,6 +10269,8 @@ relationship: BFO:0000051 GO:0005874 ! has part microtubule [Term] id: GO:0005938 name: cell cortex +def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] +xref: Wikipedia:Cell_cortex is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0071944 ! part of cell periphery @@ -7770,6 +10279,8 @@ relationship: BFO:0000050 GO:0071944 ! part of cell periphery [Term] id: GO:0005975 name: carbohydrate metabolic process +def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] +xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16646 ! has primary input or output @@ -7778,30 +10289,159 @@ relationship: RO:0004007 CHEBI:16646 ! has primary input or output [Term] id: GO:0005976 name: polysaccharide metabolic process +def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18154 ! has primary input or output relationship: RO:0004007 CHEBI:18154 ! has primary input or output +[Term] +id: GO:0005977 +name: glycogen metabolic process +def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0006112 ! energy reserve metabolic process +is_a: GO:0044042 ! glucan metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: RO:0004007 CHEBI:28087 ! has primary input or output +relationship: RO:0004007 CHEBI:28087 ! has primary input or output + +[Term] +id: GO:0005978 +name: glycogen biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] +xref: MetaCyc:GLYCOGENSYNTH-PWY +xref: MetaCyc:PWY-5067 +xref: MetaCyc:PWY-7900 +is_a: GO:0005977 ! glycogen metabolic process +is_a: GO:0009250 ! glucan biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: RO:0004008 CHEBI:28087 ! has primary output +relationship: RO:0004008 CHEBI:28087 ! has primary output + +[Term] +id: GO:0005979 +name: regulation of glycogen biosynthetic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] +is_a: GO:0010962 ! regulation of glucan biosynthetic process +is_a: GO:0070873 ! regulation of glycogen metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0005978 ! regulates glycogen biosynthetic process +relationship: RO:0002211 GO:0005978 ! regulates glycogen biosynthetic process + +[Term] +id: GO:0005980 +name: glycogen catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] +xref: MetaCyc:GLYCOCAT-PWY +xref: MetaCyc:PWY-5941 +xref: MetaCyc:PWY-7662 +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:28087 ! has primary input +relationship: RO:0004009 CHEBI:28087 ! has primary input + +[Term] +id: GO:0005981 +name: regulation of glycogen catabolic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +is_a: GO:0070873 ! regulation of glycogen metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0005980 ! regulates glycogen catabolic process +relationship: RO:0002211 GO:0005980 ! regulates glycogen catabolic process + +[Term] +id: GO:0006006 +name: glucose metabolic process +def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] +is_a: GO:0019318 ! hexose metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: RO:0004007 CHEBI:4167 ! has primary input or output +relationship: RO:0004007 CHEBI:4167 ! has primary input or output + +[Term] +id: GO:0006007 +name: glucose catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:4167 ! has primary input +relationship: RO:0004009 CHEBI:4167 ! has primary input + [Term] id: GO:0006024 name: glycosaminoglycan biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18085 ! has primary output relationship: RO:0004008 CHEBI:18085 ! has primary output +[Term] +id: GO:0006027 +name: glycosaminoglycan catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:18085 ! has primary input +relationship: RO:0004009 CHEBI:18085 ! has primary input + +[Term] +id: GO:0006082 +name: organic acid metabolic process +def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0044281 ! small molecule metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: RO:0004007 CHEBI:64709 ! has primary input or output +relationship: RO:0004007 CHEBI:64709 ! has primary input or output + +[Term] +id: GO:0006091 +name: generation of precursor metabolites and energy +def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006094 +name: gluconeogenesis +def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] +xref: MetaCyc:GLUCONEO-PWY +xref: Wikipedia:Gluconeogenesis +is_a: GO:0009058 ! biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: RO:0004008 CHEBI:4167 ! has primary output +relationship: RO:0004008 CHEBI:4167 ! has primary output + [Term] id: GO:0006109 name: regulation of carbohydrate metabolic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process relationship: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process +[Term] +id: GO:0006111 +name: regulation of gluconeogenesis +def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators] +is_a: GO:0009889 ! regulation of biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0006094 ! regulates gluconeogenesis +relationship: RO:0002211 GO:0006094 ! regulates gluconeogenesis + +[Term] +id: GO:0006112 +name: energy reserve metabolic process +def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] +is_a: GO:0015980 ! energy derivation by oxidation of organic compounds + [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process +def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:61120 ! has primary input or output @@ -7810,27 +10450,61 @@ relationship: RO:0004007 CHEBI:61120 ! has primary input or output [Term] id: GO:0006259 name: DNA metabolic process +def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16991 ! has primary input or output relationship: RO:0004007 CHEBI:16991 ! has primary input or output +[Term] +id: GO:0006308 +name: DNA catabolic process +def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732] +is_a: GO:0009057 ! macromolecule catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:16991 ! has primary input +relationship: BFO:0000051 GO:0004536 ! has part DNA nuclease activity +relationship: RO:0004009 CHEBI:16991 ! has primary input + +[Term] +id: GO:0006309 +name: apoptotic DNA fragmentation +def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] +comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). +is_a: GO:0006308 ! DNA catabolic process +intersection_of: GO:0006308 ! DNA catabolic process +intersection_of: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes +relationship: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes + [Term] id: GO:0006325 name: chromatin organization +def: "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] is_a: GO:0071824 ! protein-DNA complex organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0000785 ! results in organization of chromatin relationship: RO:0002592 GO:0000785 ! results in organization of chromatin +[Term] +id: GO:0006401 +name: RNA catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:33697 ! has primary input +relationship: RO:0004009 CHEBI:33697 ! has primary input + [Term] id: GO:0006403 name: RNA localization +def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0006412 name: translation +def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] +xref: Wikipedia:Translation_(genetics) is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0009058 ! biosynthetic process @@ -7845,6 +10519,7 @@ relationship: RO:0004008 CHEBI:36080 ! has primary output [Term] id: GO:0006413 name: translational initiation +def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] is_a: GO:0044237 ! cellular metabolic process relationship: BFO:0000050 GO:0006412 ! part of translation relationship: RO:0002224 GO:0001677 ! starts with formation of translation initiation ternary complex @@ -7852,18 +10527,21 @@ relationship: RO:0002224 GO:0001677 ! starts with formation of translation initi [Term] id: GO:0006414 name: translational elongation +def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: BFO:0000050 GO:0006412 ! part of translation [Term] id: GO:0006415 name: translational termination +def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] is_a: GO:0032984 ! protein-containing complex disassembly relationship: BFO:0000050 GO:0006412 ! part of translation [Term] id: GO:0006417 name: regulation of translation +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] is_a: GO:0010608 ! post-transcriptional regulation of gene expression is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation @@ -7873,6 +10551,7 @@ relationship: RO:0002211 GO:0006412 ! regulates translation [Term] id: GO:0006446 name: regulation of translational initiation +def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006413 ! regulates translational initiation @@ -7881,6 +10560,7 @@ relationship: RO:0002211 GO:0006413 ! regulates translational initiation [Term] id: GO:0006448 name: regulation of translational elongation +def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006414 ! regulates translational elongation @@ -7889,15 +10569,26 @@ relationship: RO:0002211 GO:0006414 ! regulates translational elongation [Term] id: GO:0006449 name: regulation of translational termination +def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006415 ! regulates translational termination relationship: RO:0002211 GO:0006415 ! regulates translational termination +[Term] +id: GO:0006516 +name: glycoprotein catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] +is_a: GO:0009057 ! macromolecule catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:17089 ! has primary input +relationship: RO:0004009 CHEBI:17089 ! has primary input + [Term] id: GO:0006518 name: peptide metabolic process +def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:60466 ! has primary input or output @@ -7906,11 +10597,13 @@ relationship: RO:0004007 CHEBI:60466 ! has primary input or output [Term] id: GO:0006576 name: biogenic amine metabolic process +def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0006584 name: catecholamine metabolic process +def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] is_a: GO:0006576 ! biogenic amine metabolic process is_a: GO:0009712 ! catechol-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process @@ -7920,19 +10613,58 @@ relationship: RO:0004007 CHEBI:33567 ! has primary input or output [Term] id: GO:0006629 name: lipid metabolic process +def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] +xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18059 ! has primary input or output relationship: RO:0004007 CHEBI:18059 ! has primary input or output +[Term] +id: GO:0006694 +name: steroid biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] +xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: RO:0004008 CHEBI:35341 ! has primary output +relationship: RO:0004008 CHEBI:35341 ! has primary output + +[Term] +id: GO:0006699 +name: bile acid biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008206 ! bile acid metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: RO:0004008 CHEBI:36235 ! has primary output +relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 {all_only="true"} ! Eumetazoa +relationship: RO:0004008 CHEBI:36235 ! has primary output + +[Term] +id: GO:0006706 +name: steroid catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:35341 ! has primary input +relationship: RO:0004009 CHEBI:35341 ! has primary input + [Term] id: GO:0006810 name: transport +def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] +comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. is_a: GO:0051234 ! establishment of localization [Term] id: GO:0006811 name: monoatomic ion transport +def: "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:24867 ! has primary input @@ -7941,6 +10673,7 @@ relationship: RO:0004009 CHEBI:24867 ! has primary input [Term] id: GO:0006837 name: serotonin transport +def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:350546 ! has primary input @@ -7949,6 +10682,7 @@ relationship: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0006858 name: extracellular transport +def: "The transport of substances that occurs outside cells." [GOC:go_curators] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region @@ -7957,15 +10691,26 @@ relationship: BFO:0000066 GO:0005576 ! occurs in extracellular region [Term] id: GO:0006869 name: lipid transport +def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:18059 ! has primary input relationship: BFO:0000050 GO:0010876 ! part of lipid localization relationship: RO:0004009 CHEBI:18059 ! has primary input +[Term] +id: GO:0006873 +name: intracellular monoatomic ion homeostasis +def: "A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah] +is_a: GO:0019725 ! cellular homeostasis +intersection_of: GO:0019725 ! cellular homeostasis +intersection_of: RO:0002332 CHEBI:24867 ! regulates levels of +relationship: RO:0002332 CHEBI:24867 ! regulates levels of + [Term] id: GO:0006886 name: intracellular protein transport +def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport @@ -7976,6 +10721,8 @@ relationship: BFO:0000050 GO:0008104 ! part of protein localization [Term] id: GO:0006887 name: exocytosis +def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285] +xref: Wikipedia:Exocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell intersection_of: GO:0006810 ! transport @@ -7986,11 +10733,13 @@ relationship: RO:0002608 GO:0070382 ! process has causal agent exocytic vesicle [Term] id: GO:0006892 name: post-Golgi vesicle-mediated transport +def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah] is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006893 name: Golgi to plasma membrane transport +def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane intersection_of: GO:0016192 ! vesicle-mediated transport @@ -8001,6 +10750,7 @@ relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus [Term] id: GO:0006896 name: Golgi to vacuole transport +def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0007034 ! vacuolar transport intersection_of: GO:0016192 ! vesicle-mediated transport @@ -8013,6 +10763,8 @@ relationship: RO:0002339 GO:0005773 ! has target end location vacuole [Term] id: GO:0006897 name: endocytosis +def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis] +xref: Wikipedia:Endocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0098657 ! import into cell relationship: BFO:0000051 GO:0006900 ! has part vesicle budding from membrane @@ -8022,6 +10774,7 @@ relationship: RO:0002339 GO:0031410 ! has target end location cytoplasmic vesicl [Term] id: GO:0006900 name: vesicle budding from membrane +def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] is_a: GO:0016050 ! vesicle organization is_a: GO:0061024 ! membrane organization relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport @@ -8029,6 +10782,7 @@ relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport [Term] id: GO:0006903 name: vesicle targeting +def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] is_a: GO:0009987 ! cellular process relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport relationship: BFO:0000050 GO:0051650 ! part of establishment of vesicle localization @@ -8036,6 +10790,7 @@ relationship: BFO:0000050 GO:0051650 ! part of establishment of vesicle localiza [Term] id: GO:0006906 name: vesicle fusion +def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] is_a: GO:0016050 ! vesicle organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0009987 ! cellular process @@ -8046,11 +10801,15 @@ relationship: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane [Term] id: GO:0006909 name: phagocytosis +def: "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] +xref: Wikipedia:Phagocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006915 name: apoptotic process +def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] +xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death relationship: RO:0002160 NCBITaxon:33154 ! Opisthokonta relationship: RO:0002162 NCBITaxon:33154 {all_only="true"} ! Opisthokonta @@ -8060,6 +10819,7 @@ relationship: RO:0002230 GO:0097194 ! ends with execution phase of apoptosis [Term] id: GO:0006921 name: cellular component disassembly involved in execution phase of apoptosis +def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb] is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: BFO:0000050 GO:0097194 ! part of execution phase of apoptosis @@ -8068,23 +10828,29 @@ relationship: BFO:0000050 GO:0097194 ! part of execution phase of apoptosis [Term] id: GO:0006925 name: inflammatory cell apoptotic process +def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis] is_a: GO:0006915 ! apoptotic process [Term] id: GO:0006935 name: chemotaxis +def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] +xref: Wikipedia:Chemotaxis is_a: GO:0042330 ! taxis relationship: BFO:0000050 GO:0042221 ! part of response to chemical [Term] id: GO:0006936 name: muscle contraction +def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] +xref: Wikipedia:Muscle_contraction is_a: GO:0003012 ! muscle system process relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue [Term] id: GO:0006937 name: regulation of muscle contraction +def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006936 ! regulates muscle contraction @@ -8093,6 +10859,7 @@ relationship: RO:0002211 GO:0006936 ! regulates muscle contraction [Term] id: GO:0006939 name: smooth muscle contraction +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732] is_a: GO:0006936 ! muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue @@ -8101,6 +10868,7 @@ relationship: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue [Term] id: GO:0006940 name: regulation of smooth muscle contraction +def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006939 ! regulates smooth muscle contraction @@ -8109,12 +10877,14 @@ relationship: RO:0002211 GO:0006939 ! regulates smooth muscle contraction [Term] id: GO:0006941 name: striated muscle contraction +def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732] is_a: GO:0006936 ! muscle contraction relationship: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue [Term] id: GO:0006942 name: regulation of striated muscle contraction +def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006941 ! regulates striated muscle contraction @@ -8123,6 +10893,7 @@ relationship: RO:0002211 GO:0006941 ! regulates striated muscle contraction [Term] id: GO:0006949 name: syncytium formation +def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732] is_a: GO:0009987 ! cellular process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis @@ -8132,16 +10903,21 @@ relationship: RO:0002297 CL:0000228 ! results in formation of multinucleate cell [Term] id: GO:0006950 name: response to stress +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006952 name: defense response +def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] is_a: GO:0006950 ! response to stress [Term] id: GO:0006954 name: inflammatory response +def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732] +xref: Wikipedia:Inflammation is_a: GO:0006952 ! defense response relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002162 NCBITaxon:7742 {all_only="true"} ! Vertebrata @@ -8149,12 +10925,15 @@ relationship: RO:0002162 NCBITaxon:7742 {all_only="true"} ! Vertebrata uPAR + long-chain fatty acid" +xref: Reactome:R-HSA-9023617 "Butyrylcholinesterase hydrolyzes acyl Ghrelin" +xref: Reactome:R-HSA-9023619 "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin" +xref: Reactome:R-HSA-9749609 "BCHE hydrolyzes ASA-" +is_a: GO:0016787 ! hydrolase activity + [Term] id: GO:0017126 name: nucleologenesis +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732] is_a: GO:0007000 ! nucleolus organization is_a: GO:0044085 ! cellular component biogenesis intersection_of: GO:0044085 ! cellular component biogenesis @@ -10892,6 +14622,7 @@ relationship: RO:0004008 GO:0005730 ! has primary output nucleolus [Term] id: GO:0017145 name: stem cell division +def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000034 ! has primary input stem cell @@ -10900,6 +14631,7 @@ relationship: RO:0004009 CL:0000034 ! has primary input stem cell [Term] id: GO:0017148 name: negative regulation of translation +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] is_a: GO:0006417 ! regulation of translation is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051248 ! negative regulation of protein metabolic process @@ -10910,6 +14642,7 @@ relationship: RO:0002212 GO:0006412 ! negatively regulates translation [Term] id: GO:0017157 name: regulation of exocytosis +def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation @@ -10919,22 +14652,45 @@ relationship: RO:0002211 GO:0006887 ! regulates exocytosis [Term] id: GO:0018958 name: phenol-containing compound metabolic process +def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] +comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. +xref: UM-BBD_pathwayID:phe is_a: GO:1901615 ! organic hydroxy compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33853 ! has primary input or output relationship: RO:0004007 CHEBI:33853 ! has primary input or output +[Term] +id: GO:0019098 +name: reproductive behavior +def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr] +is_a: GO:0007610 ! behavior +is_a: GO:0048609 ! multicellular organismal reproductive process +intersection_of: GO:0007610 ! behavior +intersection_of: GO:0048609 ! multicellular organismal reproductive process + [Term] id: GO:0019216 name: regulation of lipid metabolic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006629 ! regulates lipid metabolic process relationship: RO:0002211 GO:0006629 ! regulates lipid metabolic process +[Term] +id: GO:0019218 +name: regulation of steroid metabolic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] +is_a: GO:0019216 ! regulation of lipid metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0008202 ! regulates steroid metabolic process +relationship: RO:0002211 GO:0008202 ! regulates steroid metabolic process + [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process +def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound metabolic process @@ -10943,6 +14699,7 @@ relationship: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound m [Term] id: GO:0019222 name: regulation of metabolic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008152 ! regulates metabolic process @@ -10951,6 +14708,7 @@ relationship: RO:0002211 GO:0008152 ! regulates metabolic process [Term] id: GO:0019226 name: transmission of nerve impulse +def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194] is_a: GO:0050877 ! nervous system process relationship: BFO:0000050 GO:0007154 ! part of cell communication relationship: BFO:0000051 GO:0001508 ! has part action potential @@ -10959,6 +14717,7 @@ relationship: BFO:0000051 GO:0007268 ! has part chemical synaptic transmission [Term] id: GO:0019228 name: neuronal action potential +def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb] is_a: GO:0001508 ! action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron @@ -10968,19 +14727,71 @@ relationship: BFO:0000066 CL:0000540 ! occurs in neuron [Term] id: GO:0019233 name: sensory perception of pain +def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [GOC:curators] +xref: Wikipedia:Nociception is_a: GO:0007600 ! sensory perception +[Term] +id: GO:0019318 +name: hexose metabolic process +def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +is_a: GO:0008152 ! metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: RO:0004007 CHEBI:18133 ! has primary input or output +relationship: RO:0004007 CHEBI:18133 ! has primary input or output + +[Term] +id: GO:0019319 +name: hexose biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +is_a: GO:0009058 ! biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: RO:0004008 CHEBI:18133 ! has primary output +relationship: RO:0004008 CHEBI:18133 ! has primary output + +[Term] +id: GO:0019320 +name: hexose catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:18133 ! has primary input +relationship: RO:0004009 CHEBI:18133 ! has primary input + +[Term] +id: GO:0019336 +name: phenol-containing compound catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] +xref: MetaCyc:PHENOLDEG-PWY +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:33853 ! has primary input +relationship: RO:0004009 CHEBI:33853 ! has primary input + [Term] id: GO:0019538 name: protein metabolic process +def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +xref: Wikipedia:Protein_metabolism is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 PR:000000001 ! has primary input or output relationship: RO:0004007 PR:000000001 ! has primary input or output +[Term] +id: GO:0019614 +name: catechol-containing compound catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:33566 ! has primary input +relationship: RO:0004009 CHEBI:33566 ! has primary input + [Term] id: GO:0019725 name: cellular homeostasis +def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] is_a: GO:0042592 ! homeostatic process intersection_of: GO:0042592 ! homeostatic process intersection_of: BFO:0000066 CL:0000000 ! occurs in cell @@ -10989,24 +14800,40 @@ relationship: BFO:0000066 CL:0000000 ! occurs in cell relationship: RO:0002160 NCBITaxon:131567 ! cellular organisms relationship: RO:0002162 NCBITaxon:131567 {all_only="true"} ! cellular organisms +[Term] +id: GO:0019752 +name: carboxylic acid metabolic process +def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] +is_a: GO:0043436 ! oxoacid metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: RO:0004007 CHEBI:29067 ! has primary input or output +relationship: RO:0004007 CHEBI:29067 ! has primary input or output + [Term] id: GO:0019867 name: outer membrane +def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] is_a: GO:0016020 ! membrane [Term] id: GO:0019882 name: antigen processing and presentation +def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] +xref: Wikipedia:Antigen_presentation is_a: GO:0002376 ! immune system process [Term] id: GO:0019953 name: sexual reproduction +def: "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] +comment: Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. +xref: Wikipedia:Sexual_reproduction is_a: GO:0022414 ! reproductive process [Term] id: GO:0021501 name: prechordal plate formation +def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003063 ! results in formation of prechordal plate @@ -11016,6 +14843,7 @@ relationship: RO:0002297 UBERON:0003063 ! results in formation of prechordal pla [Term] id: GO:0021510 name: spinal cord development +def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002240 ! results in development of spinal cord @@ -11025,6 +14853,7 @@ relationship: RO:0002296 UBERON:0002240 ! results in development of spinal cord [Term] id: GO:0021514 name: ventral spinal cord interneuron differentiation +def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation @@ -11036,6 +14865,7 @@ relationship: RO:0002315 CL:0000099 ! results in acquisition of features of inte [Term] id: GO:0021515 name: cell differentiation in spinal cord +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002240 ! occurs in spinal cord @@ -11045,6 +14875,7 @@ relationship: BFO:0000066 UBERON:0002240 ! occurs in spinal cord [Term] id: GO:0021517 name: ventral spinal cord development +def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002257 ! results in development of ventral horn of spinal cord @@ -11054,6 +14885,7 @@ relationship: RO:0002296 UBERON:0002257 ! results in development of ventral horn [Term] id: GO:0021522 name: spinal cord motor neuron differentiation +def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation @@ -11064,12 +14896,14 @@ relationship: RO:0002315 CL:0011001 ! results in acquisition of features of spin [Term] id: GO:0021532 name: neural tube patterning +def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0003002 ! regionalization relationship: BFO:0000050 GO:0021915 ! part of neural tube development [Term] id: GO:0021533 name: cell differentiation in hindbrain +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain @@ -11081,6 +14915,7 @@ relationship: RO:0002162 NCBITaxon:89593 {all_only="true"} ! Craniata +relationship: RO:0002162 NCBITaxon:7742 {all_only="true"} ! Vertebrata + [Term] id: GO:1990768 name: gastric mucosal blood circulation +def: "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products." [PMID:10807413] is_a: GO:0008015 ! blood circulation intersection_of: GO:0008015 ! blood circulation intersection_of: BFO:0000066 UBERON:0004786 ! occurs in gastrointestinal system mucosa relationship: BFO:0000066 UBERON:0004786 ! occurs in gastrointestinal system mucosa +[Term] +id: GO:1990770 +name: small intestine smooth muscle contraction +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." [PMID:11991626] +is_a: GO:0006939 ! smooth muscle contraction +intersection_of: GO:0006939 ! smooth muscle contraction +intersection_of: BFO:0000066 UBERON:0002108 ! occurs in small intestine +relationship: BFO:0000050 GO:0014827 ! part of intestine smooth muscle contraction +relationship: BFO:0000066 UBERON:0002108 ! occurs in small intestine +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002162 NCBITaxon:7742 {all_only="true"} ! Vertebrata + [Term] id: GO:1990778 name: protein localization to cell periphery +def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0071944 ! has target end location cell periphery @@ -30226,14 +39325,25 @@ relationship: RO:0002339 GO:0071944 ! has target end location cell periphery [Term] id: GO:1990849 name: vacuolar localization +def: "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell." [PMID:26283797] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005773 ! has primary input vacuole relationship: RO:0004009 GO:0005773 ! has primary input vacuole +[Term] +id: GO:1990863 +name: acinar cell proliferation +def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538] +is_a: GO:0050673 ! epithelial cell proliferation +intersection_of: GO:0008283 ! cell population proliferation +intersection_of: RO:0012003 CL:0000622 ! acts on population of acinar cell +relationship: RO:0012003 CL:0000622 ! acts on population of acinar cell + [Term] id: GO:1990874 name: vascular associated smooth muscle cell proliferation +def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467] is_a: GO:0048659 ! smooth muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000359 ! acts on population of vascular associated smooth muscle cell @@ -30242,12 +39352,15 @@ relationship: RO:0012003 CL:0000359 ! acts on population of vascular associated [Term] id: GO:1990904 name: ribonucleoprotein complex +def: "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] +xref: Wikipedia:Ribonucleoprotein is_a: GO:0032991 ! protein-containing complex relationship: BFO:0000051 CHEBI:33697 ! has part [Term] id: GO:1990917 name: ooplasm +def: "The cytoplasm of an ovum." [PMID:19022436] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 CL:0000025 ! part of egg cell @@ -30256,6 +39369,7 @@ relationship: BFO:0000050 CL:0000025 ! part of egg cell [Term] id: GO:2000026 name: regulation of multicellular organismal development +def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation @@ -30265,6 +39379,7 @@ relationship: RO:0002211 GO:0007275 ! regulates multicellular organism developme [Term] id: GO:2000027 name: regulation of animal organ morphogenesis +def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis @@ -30273,6 +39388,7 @@ relationship: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis [Term] id: GO:2000035 name: regulation of stem cell division +def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0017145 ! regulates stem cell division @@ -30281,14 +39397,48 @@ relationship: RO:0002211 GO:0017145 ! regulates stem cell division [Term] id: GO:2000068 name: regulation of defense response to insect +def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol] is_a: GO:0031347 ! regulation of defense response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002213 ! regulates defense response to insect relationship: RO:0002211 GO:0002213 ! regulates defense response to insect +[Term] +id: GO:2000074 +name: regulation of type B pancreatic cell development +def: "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +is_a: GO:0060284 ! regulation of cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0003323 ! regulates type B pancreatic cell development +relationship: RO:0002211 GO:0003323 ! regulates type B pancreatic cell development + +[Term] +id: GO:2000077 +name: negative regulation of type B pancreatic cell development +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000074 ! regulation of type B pancreatic cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002212 GO:0003323 ! negatively regulates type B pancreatic cell development +relationship: RO:0002212 GO:0003323 ! negatively regulates type B pancreatic cell development + +[Term] +id: GO:2000078 +name: positive regulation of type B pancreatic cell development +def: "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000074 ! regulation of type B pancreatic cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002213 GO:0003323 ! positively regulates type B pancreatic cell development +relationship: RO:0002213 GO:0003323 ! positively regulates type B pancreatic cell development + [Term] id: GO:2000106 name: regulation of leukocyte apoptotic process +def: "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process @@ -30297,6 +39447,7 @@ relationship: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process [Term] id: GO:2000107 name: negative regulation of leukocyte apoptotic process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30306,6 +39457,7 @@ relationship: RO:0002212 GO:0071887 ! negatively regulates leukocyte apoptotic p [Term] id: GO:2000108 name: positive regulation of leukocyte apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30315,6 +39467,7 @@ relationship: RO:0002213 GO:0071887 ! positively regulates leukocyte apoptotic p [Term] id: GO:2000109 name: regulation of macrophage apoptotic process +def: "Any process that modulates the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30324,6 +39477,7 @@ relationship: RO:0002211 GO:0071888 ! regulates macrophage apoptotic process [Term] id: GO:2000110 name: negative regulation of macrophage apoptotic process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process is_a: GO:2000109 ! regulation of macrophage apoptotic process @@ -30334,6 +39488,7 @@ relationship: RO:0002212 GO:0071888 ! negatively regulates macrophage apoptotic [Term] id: GO:2000111 name: positive regulation of macrophage apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process is_a: GO:2000109 ! regulation of macrophage apoptotic process @@ -30344,6 +39499,7 @@ relationship: RO:0002213 GO:0071888 ! positively regulates macrophage apoptotic [Term] id: GO:2000114 name: regulation of establishment of cell polarity +def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030010 ! regulates establishment of cell polarity @@ -30352,6 +39508,7 @@ relationship: RO:0002211 GO:0030010 ! regulates establishment of cell polarity [Term] id: GO:2000136 name: regulation of cell proliferation involved in heart morphogenesis +def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061323 ! regulates cell proliferation involved in heart morphogenesis @@ -30360,6 +39517,7 @@ relationship: RO:0002211 GO:0061323 ! regulates cell proliferation involved in h [Term] id: GO:2000137 name: negative regulation of cell proliferation involved in heart morphogenesis +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation @@ -30369,6 +39527,7 @@ relationship: RO:0002212 GO:0061323 ! negatively regulates cell proliferation in [Term] id: GO:2000138 name: positive regulation of cell proliferation involved in heart morphogenesis +def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation @@ -30378,6 +39537,7 @@ relationship: RO:0002213 GO:0061323 ! positively regulates cell proliferation in [Term] id: GO:2000145 name: regulation of cell motility +def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation @@ -30387,6 +39547,7 @@ relationship: RO:0002211 GO:0048870 ! regulates cell motility [Term] id: GO:2000146 name: negative regulation of cell motility +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000145 ! regulation of cell motility @@ -30397,6 +39558,7 @@ relationship: RO:0002212 GO:0048870 ! negatively regulates cell motility [Term] id: GO:2000147 name: positive regulation of cell motility +def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000145 ! regulation of cell motility @@ -30407,6 +39569,7 @@ relationship: RO:0002213 GO:0048870 ! positively regulates cell motility [Term] id: GO:2000155 name: positive regulation of cilium-dependent cell motility +def: "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000147 ! positive regulation of cell motility intersection_of: GO:0065007 ! biological regulation @@ -30416,6 +39579,7 @@ relationship: RO:0002213 GO:0060285 ! positively regulates cilium-dependent cell [Term] id: GO:2000172 name: regulation of branching morphogenesis of a nerve +def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a nerve @@ -30424,6 +39588,7 @@ relationship: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a ner [Term] id: GO:2000173 name: negative regulation of branching morphogenesis of a nerve +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve @@ -30434,6 +39599,7 @@ relationship: RO:0002212 GO:0048755 ! negatively regulates branching morphogenes [Term] id: GO:2000174 name: regulation of pro-T cell differentiation +def: "Any process that modulates the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -30443,6 +39609,7 @@ relationship: RO:0002211 GO:0002572 ! regulates pro-T cell differentiation [Term] id: GO:2000175 name: negative regulation of pro-T cell differentiation +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation @@ -30453,6 +39620,7 @@ relationship: RO:0002212 GO:0002572 ! negatively regulates pro-T cell differenti [Term] id: GO:2000176 name: positive regulation of pro-T cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation @@ -30463,6 +39631,7 @@ relationship: RO:0002213 GO:0002572 ! positively regulates pro-T cell differenti [Term] id: GO:2000177 name: regulation of neural precursor cell proliferation +def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferation @@ -30471,6 +39640,7 @@ relationship: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferat [Term] id: GO:2000178 name: negative regulation of neural precursor cell proliferation +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -30480,6 +39650,7 @@ relationship: RO:0002212 GO:0061351 ! negatively regulates neural precursor cell [Term] id: GO:2000179 name: positive regulation of neural precursor cell proliferation +def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -30489,6 +39660,7 @@ relationship: RO:0002213 GO:0061351 ! positively regulates neural precursor cell [Term] id: GO:2000181 name: negative regulation of blood vessel morphogenesis +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901343 ! negative regulation of vasculature development intersection_of: GO:0065007 ! biological regulation @@ -30498,6 +39670,7 @@ relationship: RO:0002212 GO:0048514 ! negatively regulates blood vessel morphoge [Term] id: GO:2000194 name: regulation of female gonad development +def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol] is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation @@ -30507,6 +39680,7 @@ relationship: RO:0002211 GO:0008585 ! regulates female gonad development [Term] id: GO:2000195 name: negative regulation of female gonad development +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol] is_a: GO:1905940 ! negative regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0065007 ! biological regulation @@ -30516,15 +39690,48 @@ relationship: RO:0002212 GO:0008585 ! negatively regulates female gonad developm [Term] id: GO:2000196 name: positive regulation of female gonad development +def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol] is_a: GO:1905941 ! positive regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008585 ! positively regulates female gonad development relationship: RO:0002213 GO:0008585 ! positively regulates female gonad development +[Term] +id: GO:2000226 +name: regulation of pancreatic A cell differentiation +def: "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0003310 ! regulates pancreatic A cell differentiation +relationship: RO:0002211 GO:0003310 ! regulates pancreatic A cell differentiation + +[Term] +id: GO:2000227 +name: negative regulation of pancreatic A cell differentiation +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000226 ! regulation of pancreatic A cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002212 GO:0003310 ! negatively regulates pancreatic A cell differentiation +relationship: RO:0002212 GO:0003310 ! negatively regulates pancreatic A cell differentiation + +[Term] +id: GO:2000228 +name: positive regulation of pancreatic A cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000226 ! regulation of pancreatic A cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002213 GO:0003310 ! positively regulates pancreatic A cell differentiation +relationship: RO:0002213 GO:0003310 ! positively regulates pancreatic A cell differentiation + [Term] id: GO:2000241 name: regulation of reproductive process +def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022414 ! regulates reproductive process @@ -30533,6 +39740,7 @@ relationship: RO:0002211 GO:0022414 ! regulates reproductive process [Term] id: GO:2000242 name: negative regulation of reproductive process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation @@ -30542,6 +39750,7 @@ relationship: RO:0002212 GO:0022414 ! negatively regulates reproductive process [Term] id: GO:2000243 name: positive regulation of reproductive process +def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation @@ -30551,6 +39760,7 @@ relationship: RO:0002213 GO:0022414 ! positively regulates reproductive process [Term] id: GO:2000248 name: negative regulation of establishment or maintenance of neuroblast polarity +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity is_a: GO:0045769 ! negative regulation of asymmetric cell division @@ -30561,6 +39771,7 @@ relationship: RO:0002212 GO:0045196 ! negatively regulates establishment or main [Term] id: GO:2000269 name: regulation of fibroblast apoptotic process +def: "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process @@ -30569,6 +39780,7 @@ relationship: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process [Term] id: GO:2000270 name: negative regulation of fibroblast apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30578,6 +39790,7 @@ relationship: RO:0002212 GO:0044346 ! negatively regulates fibroblast apoptotic [Term] id: GO:2000271 name: positive regulation of fibroblast apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30587,6 +39800,7 @@ relationship: RO:0002213 GO:0044346 ! positively regulates fibroblast apoptotic [Term] id: GO:2000278 name: regulation of DNA biosynthetic process +def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071897 ! regulates DNA biosynthetic process @@ -30595,6 +39809,7 @@ relationship: RO:0002211 GO:0071897 ! regulates DNA biosynthetic process [Term] id: GO:2000279 name: negative regulation of DNA biosynthetic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0065007 ! biological regulation @@ -30604,6 +39819,7 @@ relationship: RO:0002212 GO:0071897 ! negatively regulates DNA biosynthetic proc [Term] id: GO:2000287 name: positive regulation of myotome development +def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000290 ! regulation of myotome development intersection_of: GO:0065007 ! biological regulation @@ -30613,6 +39829,7 @@ relationship: RO:0002213 GO:0061055 ! positively regulates myotome development [Term] id: GO:2000288 name: positive regulation of myoblast proliferation +def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation @@ -30622,6 +39839,7 @@ relationship: RO:0002213 GO:0051450 ! positively regulates myoblast proliferatio [Term] id: GO:2000290 name: regulation of myotome development +def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061055 ! regulates myotome development @@ -30630,14 +39848,48 @@ relationship: RO:0002211 GO:0061055 ! regulates myotome development [Term] id: GO:2000291 name: regulation of myoblast proliferation +def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051450 ! regulates myoblast proliferation relationship: RO:0002211 GO:0051450 ! regulates myoblast proliferation +[Term] +id: GO:2000292 +name: regulation of defecation +def: "Any process that modulates the frequency, rate or extent of defecation." [GOC:obol] +is_a: GO:0044058 ! regulation of digestive system process +is_a: GO:0044062 ! regulation of excretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0030421 ! regulates defecation +relationship: RO:0002211 GO:0030421 ! regulates defecation + +[Term] +id: GO:2000293 +name: negative regulation of defecation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." [GOC:obol] +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0060457 ! negative regulation of digestive system process +is_a: GO:2000292 ! regulation of defecation +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002212 GO:0030421 ! negatively regulates defecation +relationship: RO:0002212 GO:0030421 ! negatively regulates defecation + +[Term] +id: GO:2000294 +name: positive regulation of defecation +def: "Any process that activates or increases the frequency, rate or extent of defecation." [GOC:obol] +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0060456 ! positive regulation of digestive system process +is_a: GO:2000292 ! regulation of defecation +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002213 GO:0030421 ! positively regulates defecation +relationship: RO:0002213 GO:0030421 ! positively regulates defecation + [Term] id: GO:2000351 name: regulation of endothelial cell apoptotic process +def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process @@ -30646,6 +39898,7 @@ relationship: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic proce [Term] id: GO:2000352 name: negative regulation of endothelial cell apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30655,6 +39908,7 @@ relationship: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apop [Term] id: GO:2000353 name: positive regulation of endothelial cell apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30664,6 +39918,7 @@ relationship: RO:0002213 GO:0072577 ! positively regulates endothelial cell apop [Term] id: GO:2000374 name: regulation of oxygen metabolic process +def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072592 ! regulates oxygen metabolic process @@ -30672,6 +39927,7 @@ relationship: RO:0002211 GO:0072592 ! regulates oxygen metabolic process [Term] id: GO:2000375 name: negative regulation of oxygen metabolic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process." [GOC:mah] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process intersection_of: GO:0065007 ! biological regulation @@ -30681,6 +39937,7 @@ relationship: RO:0002212 GO:0072592 ! negatively regulates oxygen metabolic proc [Term] id: GO:2000376 name: positive regulation of oxygen metabolic process +def: "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process." [GOC:mah] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process intersection_of: GO:0065007 ! biological regulation @@ -30690,6 +39947,7 @@ relationship: RO:0002213 GO:0072592 ! positively regulates oxygen metabolic proc [Term] id: GO:2000380 name: regulation of mesoderm development +def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007498 ! regulates mesoderm development @@ -30698,6 +39956,7 @@ relationship: RO:0002211 GO:0007498 ! regulates mesoderm development [Term] id: GO:2000381 name: negative regulation of mesoderm development +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation @@ -30707,6 +39966,7 @@ relationship: RO:0002212 GO:0007498 ! negatively regulates mesoderm development [Term] id: GO:2000382 name: positive regulation of mesoderm development +def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation @@ -30716,6 +39976,7 @@ relationship: RO:0002213 GO:0007498 ! positively regulates mesoderm development [Term] id: GO:2000383 name: regulation of ectoderm development +def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007398 ! regulates ectoderm development @@ -30724,6 +39985,7 @@ relationship: RO:0002211 GO:0007398 ! regulates ectoderm development [Term] id: GO:2000384 name: negative regulation of ectoderm development +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation @@ -30733,6 +39995,7 @@ relationship: RO:0002212 GO:0007398 ! negatively regulates ectoderm development [Term] id: GO:2000385 name: positive regulation of ectoderm development +def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation @@ -30742,6 +40005,7 @@ relationship: RO:0002213 GO:0007398 ! positively regulates ectoderm development [Term] id: GO:2000401 name: regulation of lymphocyte migration +def: "Any process that modulates the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072676 ! regulates lymphocyte migration @@ -30750,6 +40014,7 @@ relationship: RO:0002211 GO:0072676 ! regulates lymphocyte migration [Term] id: GO:2000402 name: negative regulation of lymphocyte migration +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation @@ -30759,6 +40024,7 @@ relationship: RO:0002212 GO:0072676 ! negatively regulates lymphocyte migration [Term] id: GO:2000403 name: positive regulation of lymphocyte migration +def: "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation @@ -30768,6 +40034,7 @@ relationship: RO:0002213 GO:0072676 ! positively regulates lymphocyte migration [Term] id: GO:2000404 name: regulation of T cell migration +def: "Any process that modulates the frequency, rate or extent of T cell migration." [GOC:mah] is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072678 ! regulates T cell migration @@ -30776,6 +40043,7 @@ relationship: RO:0002211 GO:0072678 ! regulates T cell migration [Term] id: GO:2000405 name: negative regulation of T cell migration +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah] is_a: GO:2000402 ! negative regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0065007 ! biological regulation @@ -30785,6 +40053,7 @@ relationship: RO:0002212 GO:0072678 ! negatively regulates T cell migration [Term] id: GO:2000406 name: positive regulation of T cell migration +def: "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah] is_a: GO:2000403 ! positive regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0065007 ! biological regulation @@ -30794,6 +40063,7 @@ relationship: RO:0002213 GO:0072678 ! positively regulates T cell migration [Term] id: GO:2000471 name: regulation of hematopoietic stem cell migration +def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035701 ! regulates hematopoietic stem cell migration @@ -30802,6 +40072,7 @@ relationship: RO:0002211 GO:0035701 ! regulates hematopoietic stem cell migratio [Term] id: GO:2000472 name: negative regulation of hematopoietic stem cell migration +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration intersection_of: GO:0065007 ! biological regulation @@ -30811,6 +40082,7 @@ relationship: RO:0002212 GO:0035701 ! negatively regulates hematopoietic stem ce [Term] id: GO:2000473 name: positive regulation of hematopoietic stem cell migration +def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration intersection_of: GO:0065007 ! biological regulation @@ -30820,6 +40092,7 @@ relationship: RO:0002213 GO:0035701 ! positively regulates hematopoietic stem ce [Term] id: GO:2000495 name: regulation of cell proliferation involved in compound eye morphogenesis +def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035736 ! regulates cell proliferation involved in compound eye morphogenesis @@ -30828,6 +40101,7 @@ relationship: RO:0002211 GO:0035736 ! regulates cell proliferation involved in c [Term] id: GO:2000496 name: negative regulation of cell proliferation involved in compound eye morphogenesis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0065007 ! biological regulation @@ -30837,6 +40111,7 @@ relationship: RO:0002212 GO:0035736 ! negatively regulates cell proliferation in [Term] id: GO:2000497 name: positive regulation of cell proliferation involved in compound eye morphogenesis +def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0065007 ! biological regulation @@ -30846,6 +40121,7 @@ relationship: RO:0002213 GO:0035736 ! positively regulates cell proliferation in [Term] id: GO:2000508 name: regulation of dendritic cell chemotaxis +def: "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation @@ -30855,6 +40131,7 @@ relationship: RO:0002211 GO:0002407 ! regulates dendritic cell chemotaxis [Term] id: GO:2000509 name: negative regulation of dendritic cell chemotaxis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:2000508 ! regulation of dendritic cell chemotaxis @@ -30865,6 +40142,7 @@ relationship: RO:0002212 GO:0002407 ! negatively regulates dendritic cell chemot [Term] id: GO:2000510 name: positive regulation of dendritic cell chemotaxis +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:2000508 ! regulation of dendritic cell chemotaxis @@ -30875,6 +40153,7 @@ relationship: RO:0002213 GO:0002407 ! positively regulates dendritic cell chemot [Term] id: GO:2000527 name: regulation of myeloid dendritic cell chemotaxis +def: "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000508 ! regulation of dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002408 ! regulates myeloid dendritic cell chemotaxis @@ -30883,6 +40162,7 @@ relationship: RO:0002211 GO:0002408 ! regulates myeloid dendritic cell chemotaxi [Term] id: GO:2000528 name: negative regulation of myeloid dendritic cell chemotaxis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000509 ! negative regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation @@ -30892,6 +40172,7 @@ relationship: RO:0002212 GO:0002408 ! negatively regulates myeloid dendritic cel [Term] id: GO:2000529 name: positive regulation of myeloid dendritic cell chemotaxis +def: "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000510 ! positive regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation @@ -30901,6 +40182,7 @@ relationship: RO:0002213 GO:0002408 ! positively regulates myeloid dendritic cel [Term] id: GO:2000542 name: negative regulation of gastrulation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0045992 ! negative regulation of embryonic development intersection_of: GO:0065007 ! biological regulation @@ -30910,6 +40192,7 @@ relationship: RO:0002212 GO:0007369 ! negatively regulates gastrulation [Term] id: GO:2000543 name: positive regulation of gastrulation +def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0040019 ! positive regulation of embryonic development intersection_of: GO:0065007 ! biological regulation @@ -30919,6 +40202,7 @@ relationship: RO:0002213 GO:0007369 ! positively regulates gastrulation [Term] id: GO:2000547 name: regulation of dendritic cell dendrite assembly +def: "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097026 ! regulates dendritic cell dendrite assembly @@ -30927,6 +40211,7 @@ relationship: RO:0002211 GO:0097026 ! regulates dendritic cell dendrite assembly [Term] id: GO:2000548 name: negative regulation of dendritic cell dendrite assembly +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly intersection_of: GO:0065007 ! biological regulation @@ -30936,6 +40221,7 @@ relationship: RO:0002212 GO:0097026 ! negatively regulates dendritic cell dendri [Term] id: GO:2000549 name: positive regulation of dendritic cell dendrite assembly +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly intersection_of: GO:0065007 ! biological regulation @@ -30945,6 +40231,7 @@ relationship: RO:0002213 GO:0097026 ! positively regulates dendritic cell dendri [Term] id: GO:2000573 name: positive regulation of DNA biosynthetic process +def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0065007 ! biological regulation @@ -30954,6 +40241,7 @@ relationship: RO:0002213 GO:0071897 ! positively regulates DNA biosynthetic proc [Term] id: GO:2000647 name: negative regulation of stem cell proliferation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -30963,6 +40251,7 @@ relationship: RO:0002212 GO:0072089 ! negatively regulates stem cell proliferati [Term] id: GO:2000648 name: positive regulation of stem cell proliferation +def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -30972,6 +40261,7 @@ relationship: RO:0002213 GO:0072089 ! positively regulates stem cell proliferati [Term] id: GO:2000668 name: regulation of dendritic cell apoptotic process +def: "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097048 ! regulates dendritic cell apoptotic process @@ -30980,6 +40270,7 @@ relationship: RO:0002211 GO:0097048 ! regulates dendritic cell apoptotic process [Term] id: GO:2000669 name: negative regulation of dendritic cell apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process is_a: GO:2000668 ! regulation of dendritic cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30989,6 +40280,7 @@ relationship: RO:0002212 GO:0097048 ! negatively regulates dendritic cell apopto [Term] id: GO:2000670 name: positive regulation of dendritic cell apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process is_a: GO:2000668 ! regulation of dendritic cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30998,6 +40290,7 @@ relationship: RO:0002213 GO:0097048 ! positively regulates dendritic cell apopto [Term] id: GO:2000671 name: regulation of motor neuron apoptotic process +def: "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process @@ -31006,6 +40299,7 @@ relationship: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process [Term] id: GO:2000672 name: negative regulation of motor neuron apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -31015,15 +40309,46 @@ relationship: RO:0002212 GO:0097049 ! negatively regulates motor neuron apoptoti [Term] id: GO:2000673 name: positive regulation of motor neuron apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0043525 ! positive regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process relationship: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process +[Term] +id: GO:2000674 +name: regulation of type B pancreatic cell apoptotic process +def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0097050 ! regulates type B pancreatic cell apoptotic process +relationship: RO:0002211 GO:0097050 ! regulates type B pancreatic cell apoptotic process + +[Term] +id: GO:2000675 +name: negative regulation of type B pancreatic cell apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002212 GO:0097050 ! negatively regulates type B pancreatic cell apoptotic process +relationship: RO:0002212 GO:0097050 ! negatively regulates type B pancreatic cell apoptotic process + +[Term] +id: GO:2000676 +name: positive regulation of type B pancreatic cell apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002213 GO:0097050 ! positively regulates type B pancreatic cell apoptotic process +relationship: RO:0002213 GO:0097050 ! positively regulates type B pancreatic cell apoptotic process + [Term] id: GO:2000690 name: regulation of cardiac muscle cell myoblast differentiation +def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] is_a: GO:0045661 ! regulation of myoblast differentiation is_a: GO:0051890 ! regulation of cardioblast differentiation intersection_of: GO:0065007 ! biological regulation @@ -31033,6 +40358,7 @@ relationship: RO:0002211 GO:0060379 ! regulates cardiac muscle cell myoblast dif [Term] id: GO:2000691 name: negative regulation of cardiac muscle cell myoblast differentiation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] is_a: GO:0045662 ! negative regulation of myoblast differentiation is_a: GO:0051892 ! negative regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation @@ -31043,6 +40369,7 @@ relationship: RO:0002212 GO:0060379 ! negatively regulates cardiac muscle cell m [Term] id: GO:2000700 name: positive regulation of cardiac muscle cell myoblast differentiation +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] is_a: GO:0045663 ! positive regulation of myoblast differentiation is_a: GO:0051891 ! positive regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation @@ -31053,6 +40380,7 @@ relationship: RO:0002213 GO:0060379 ! positively regulates cardiac muscle cell m [Term] id: GO:2000725 name: regulation of cardiac muscle cell differentiation +def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] is_a: GO:0051153 ! regulation of striated muscle cell differentiation is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0065007 ! biological regulation @@ -31062,6 +40390,7 @@ relationship: RO:0002211 GO:0055007 ! regulates cardiac muscle cell differentiat [Term] id: GO:2000726 name: negative regulation of cardiac muscle cell differentiation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation @@ -31072,6 +40401,7 @@ relationship: RO:0002212 GO:0055007 ! negatively regulates cardiac muscle cell d [Term] id: GO:2000727 name: positive regulation of cardiac muscle cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation @@ -31082,6 +40412,7 @@ relationship: RO:0002213 GO:0055007 ! positively regulates cardiac muscle cell d [Term] id: GO:2000736 name: regulation of stem cell differentiation +def: "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048863 ! regulates stem cell differentiation @@ -31090,6 +40421,7 @@ relationship: RO:0002211 GO:0048863 ! regulates stem cell differentiation [Term] id: GO:2000737 name: negative regulation of stem cell differentiation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31099,6 +40431,7 @@ relationship: RO:0002212 GO:0048863 ! negatively regulates stem cell differentia [Term] id: GO:2000738 name: positive regulation of stem cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31108,6 +40441,7 @@ relationship: RO:0002213 GO:0048863 ! positively regulates stem cell differentia [Term] id: GO:2000790 name: regulation of mesenchymal cell proliferation involved in lung development +def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation involved in lung development @@ -31116,6 +40450,7 @@ relationship: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation i [Term] id: GO:2000791 name: negative regulation of mesenchymal cell proliferation involved in lung development +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation @@ -31127,6 +40462,7 @@ relationship: RO:0002212 GO:0060916 ! negatively regulates mesenchymal cell prol [Term] id: GO:2000792 name: positive regulation of mesenchymal cell proliferation involved in lung development +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process @@ -31138,6 +40474,7 @@ relationship: RO:0002213 GO:0060916 ! positively regulates mesenchymal cell prol [Term] id: GO:2000794 name: regulation of epithelial cell proliferation involved in lung morphogenesis +def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation involved in lung morphogenesis @@ -31146,6 +40483,7 @@ relationship: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation in [Term] id: GO:2000795 name: negative regulation of epithelial cell proliferation involved in lung morphogenesis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis intersection_of: GO:0065007 ! biological regulation @@ -31155,6 +40493,7 @@ relationship: RO:0002212 GO:0060502 ! negatively regulates epithelial cell proli [Term] id: GO:2000818 name: negative regulation of myoblast proliferation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation @@ -31164,6 +40503,7 @@ relationship: RO:0002212 GO:0051450 ! negatively regulates myoblast proliferatio [Term] id: GO:2000826 name: regulation of heart morphogenesis +def: "Any process that modulates the frequency, rate or extent of heart morphogenesis." [GOC:BHF] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003007 ! regulates heart morphogenesis @@ -31172,6 +40512,7 @@ relationship: RO:0002211 GO:0003007 ! regulates heart morphogenesis [Term] id: GO:2000831 name: regulation of steroid hormone secretion +def: "Any process that modulates the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion @@ -31182,6 +40523,7 @@ relationship: RO:0002211 GO:0035929 ! regulates steroid hormone secretion [Term] id: GO:2000832 name: negative regulation of steroid hormone secretion +def: "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process @@ -31193,6 +40535,7 @@ relationship: RO:0002212 GO:0035929 ! negatively regulates steroid hormone secre [Term] id: GO:2000833 name: positive regulation of steroid hormone secretion +def: "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process @@ -31204,6 +40547,7 @@ relationship: RO:0002213 GO:0035929 ! positively regulates steroid hormone secre [Term] id: GO:2000834 name: regulation of androgen secretion +def: "Any process that modulates the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035935 ! regulates androgen secretion @@ -31212,6 +40556,7 @@ relationship: RO:0002211 GO:0035935 ! regulates androgen secretion [Term] id: GO:2000835 name: negative regulation of androgen secretion +def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0065007 ! biological regulation @@ -31221,15 +40566,26 @@ relationship: RO:0002212 GO:0035935 ! negatively regulates androgen secretion [Term] id: GO:2000836 name: positive regulation of androgen secretion +def: "Any process that activates or increases the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035935 ! positively regulates androgen secretion relationship: RO:0002213 GO:0035935 ! positively regulates androgen secretion +[Term] +id: GO:2001012 +name: mesenchymal cell differentiation involved in renal system development +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +is_a: GO:0048762 ! mesenchymal cell differentiation +intersection_of: GO:0048762 ! mesenchymal cell differentiation +intersection_of: BFO:0000050 GO:0072001 ! part of renal system development +relationship: BFO:0000050 GO:0072001 ! part of renal system development + [Term] id: GO:2001014 name: regulation of skeletal muscle cell differentiation +def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentiation @@ -31238,6 +40594,7 @@ relationship: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentia [Term] id: GO:2001015 name: negative regulation of skeletal muscle cell differentiation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31247,6 +40604,7 @@ relationship: RO:0002212 GO:0035914 ! negatively regulates skeletal muscle cell [Term] id: GO:2001016 name: positive regulation of skeletal muscle cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31256,6 +40614,7 @@ relationship: RO:0002213 GO:0035914 ! positively regulates skeletal muscle cell [Term] id: GO:2001026 name: regulation of endothelial cell chemotaxis +def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation @@ -31265,6 +40624,7 @@ relationship: RO:0002211 GO:0035767 ! regulates endothelial cell chemotaxis [Term] id: GO:2001027 name: negative regulation of endothelial cell chemotaxis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010596 ! negative regulation of endothelial cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:2001026 ! regulation of endothelial cell chemotaxis @@ -31275,6 +40635,7 @@ relationship: RO:0002212 GO:0035767 ! negatively regulates endothelial cell chem [Term] id: GO:2001028 name: positive regulation of endothelial cell chemotaxis +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010595 ! positive regulation of endothelial cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:2001026 ! regulation of endothelial cell chemotaxis @@ -31285,6 +40646,7 @@ relationship: RO:0002213 GO:0035767 ! positively regulates endothelial cell chem [Term] id: GO:2001053 name: regulation of mesenchymal cell apoptotic process +def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097152 ! regulates mesenchymal cell apoptotic process @@ -31293,6 +40655,7 @@ relationship: RO:0002211 GO:0097152 ! regulates mesenchymal cell apoptotic proce [Term] id: GO:2001054 name: negative regulation of mesenchymal cell apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -31302,6 +40665,7 @@ relationship: RO:0002212 GO:0097152 ! negatively regulates mesenchymal cell apop [Term] id: GO:2001055 name: positive regulation of mesenchymal cell apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -31311,6 +40675,7 @@ relationship: RO:0002213 GO:0097152 ! positively regulates mesenchymal cell apop [Term] id: GO:2001141 name: regulation of RNA biosynthetic process +def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032774 ! regulates RNA biosynthetic process @@ -31319,6 +40684,7 @@ relationship: RO:0002211 GO:0032774 ! regulates RNA biosynthetic process [Term] id: GO:2001198 name: regulation of dendritic cell differentiation +def: "Any process that modulates the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097028 ! regulates dendritic cell differentiation @@ -31327,6 +40693,7 @@ relationship: RO:0002211 GO:0097028 ! regulates dendritic cell differentiation [Term] id: GO:2001199 name: negative regulation of dendritic cell differentiation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902106 ! negative regulation of leukocyte differentiation is_a: GO:2001198 ! regulation of dendritic cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31336,6 +40703,7 @@ relationship: RO:0002212 GO:0097028 ! negatively regulates dendritic cell differ [Term] id: GO:2001200 name: positive regulation of dendritic cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902107 ! positive regulation of leukocyte differentiation is_a: GO:2001198 ! regulation of dendritic cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31345,6 +40713,7 @@ relationship: RO:0002213 GO:0097028 ! positively regulates dendritic cell differ [Term] id: GO:2001204 name: regulation of osteoclast development +def: "Any process that modulates the frequency, rate or extent of osteoclast development." [GOC:obol] is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036035 ! regulates osteoclast development @@ -31353,6 +40722,7 @@ relationship: RO:0002211 GO:0036035 ! regulates osteoclast development [Term] id: GO:2001205 name: negative regulation of osteoclast development +def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development." [GOC:obol] is_a: GO:0045671 ! negative regulation of osteoclast differentiation is_a: GO:2001204 ! regulation of osteoclast development intersection_of: GO:0065007 ! biological regulation @@ -31362,6 +40732,7 @@ relationship: RO:0002212 GO:0036035 ! negatively regulates osteoclast developmen [Term] id: GO:2001206 name: positive regulation of osteoclast development +def: "Any process that activates or increases the frequency, rate or extent of osteoclast development." [GOC:obol] is_a: GO:0045672 ! positive regulation of osteoclast differentiation is_a: GO:2001204 ! regulation of osteoclast development intersection_of: GO:0065007 ! biological regulation @@ -31371,6 +40742,7 @@ relationship: RO:0002213 GO:0036035 ! positively regulates osteoclast developmen [Term] id: GO:2001212 name: regulation of vasculogenesis +def: "Any process that modulates the frequency, rate or extent of vasculogenesis." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001570 ! regulates vasculogenesis @@ -31379,6 +40751,7 @@ relationship: RO:0002211 GO:0001570 ! regulates vasculogenesis [Term] id: GO:2001213 name: negative regulation of vasculogenesis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0065007 ! biological regulation @@ -31388,6 +40761,7 @@ relationship: RO:0002212 GO:0001570 ! negatively regulates vasculogenesis [Term] id: GO:2001214 name: positive regulation of vasculogenesis +def: "Any process that activates or increases the frequency, rate or extent of vasculogenesis." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0065007 ! biological regulation @@ -31397,6 +40771,7 @@ relationship: RO:0002213 GO:0001570 ! positively regulates vasculogenesis [Term] id: GO:2001222 name: regulation of neuron migration +def: "Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001764 ! regulates neuron migration @@ -31407,6 +40782,7 @@ relationship: RO:0002211 GO:0001764 ! regulates neuron migration [Term] id: GO:2001223 name: negative regulation of neuron migration +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration." [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0065007 ! biological regulation @@ -31416,6 +40792,7 @@ relationship: RO:0002212 GO:0001764 ! negatively regulates neuron migration [Term] id: GO:2001224 name: positive regulation of neuron migration +def: "Any process that activates or increases the frequency, rate or extent of neuron migration." [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0065007 ! biological regulation @@ -31425,6 +40802,7 @@ relationship: RO:0002213 GO:0001764 ! positively regulates neuron migration [Term] id: GO:2001233 name: regulation of apoptotic signaling pathway +def: "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -31434,6 +40812,7 @@ relationship: RO:0002211 GO:0097190 ! regulates apoptotic signaling pathway [Term] id: GO:2001234 name: negative regulation of apoptotic signaling pathway +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway @@ -31444,6 +40823,7 @@ relationship: RO:0002212 GO:0097190 ! negatively regulates apoptotic signaling p [Term] id: GO:2001235 name: positive regulation of apoptotic signaling pathway +def: "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway @@ -31454,6 +40834,7 @@ relationship: RO:0002213 GO:0097190 ! positively regulates apoptotic signaling p [Term] id: GO:2001251 name: negative regulation of chromosome organization +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation @@ -31463,6 +40844,7 @@ relationship: RO:0002212 GO:0051276 ! negatively regulates chromosome organizati [Term] id: GO:2001252 name: positive regulation of chromosome organization +def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation @@ -31472,448 +40854,730 @@ relationship: RO:0002213 GO:0051276 ! positively regulates chromosome organizati [Term] id: NCBITaxon:1 name: root +xref: GC_ID:1 +xref: PMID:30365038 +xref: PMID:32761142 [Term] id: NCBITaxon:117570 name: Teleostomi +xref: GC_ID:1 is_a: NCBITaxon:7776 ! Gnathostomata [Term] id: NCBITaxon:117571 name: Euteleostomi +xref: GC_ID:1 is_a: NCBITaxon:117570 ! Teleostomi [Term] id: NCBITaxon:1206794 name: Ecdysozoa +xref: GC_ID:1 is_a: NCBITaxon:33317 ! Protostomia [Term] id: NCBITaxon:131209 name: Zygnemophyceae +xref: GC_ID:1 is_a: NCBITaxon:131221 ! Streptophytina [Term] id: NCBITaxon:131221 name: Streptophytina +xref: GC_ID:1 is_a: NCBITaxon:35493 ! Streptophyta [Term] id: NCBITaxon:131567 name: cellular organisms +xref: GC_ID:1 is_a: NCBITaxon:1 ! root [Term] id: NCBITaxon:1329799 name: Archelosauria +xref: GC_ID:1 +xref: PMID:22839753 +xref: PMID:25450099 is_a: NCBITaxon:32561 ! Sauria [Term] id: NCBITaxon:1338369 name: Dipnotetrapodomorpha +xref: GC_ID:1 is_a: NCBITaxon:8287 ! Sarcopterygii [Term] id: NCBITaxon:142796 name: Eumycetozoa +xref: GC_ID:1 +xref: PMID:11062127 +xref: PMID:9342353 is_a: NCBITaxon:2605435 ! Evosea +[Term] +id: NCBITaxon:1437010 +name: Boreoeutheria +xref: GC_ID:1 +xref: PMID:11743200 +xref: PMID:11791233 +is_a: NCBITaxon:9347 ! Eutheria + [Term] id: NCBITaxon:1437180 name: Acrogymnospermae +xref: GC_ID:1 is_a: NCBITaxon:58024 ! Spermatophyta [Term] id: NCBITaxon:1445966 name: Gnetidae +xref: GC_ID:1 is_a: NCBITaxon:3372 ! Gnetopsida [Term] id: NCBITaxon:147537 name: Saccharomycotina +xref: GC_ID:1 is_a: NCBITaxon:716545 ! saccharomyceta [Term] id: NCBITaxon:147554 name: Schizosaccharomycetes +xref: GC_ID:1 is_a: NCBITaxon:451866 ! Taphrinomycotina [Term] id: NCBITaxon:186623 name: Actinopteri +xref: GC_ID:1 is_a: NCBITaxon:7898 ! Actinopterygii [Term] id: NCBITaxon:197562 name: Pancrustacea +xref: GC_ID:1 +xref: PMID:10874751 +xref: PMID:11557979 is_a: NCBITaxon:197563 ! Mandibulata [Term] id: NCBITaxon:197563 name: Mandibulata +xref: GC_ID:1 +xref: PMID:11557979 +xref: PMID:9727836 is_a: NCBITaxon:6656 ! Arthropoda [Term] id: NCBITaxon:2 name: Bacteria +xref: GC_ID:11 +xref: PMID:10425795 +xref: PMID:10425796 +xref: PMID:10425797 +xref: PMID:10490293 +xref: PMID:10843050 +xref: PMID:10939651 +xref: PMID:10939673 +xref: PMID:10939677 +xref: PMID:11211268 +xref: PMID:11321083 +xref: PMID:11321113 +xref: PMID:11411719 +xref: PMID:11540071 +xref: PMID:11542017 +xref: PMID:11542087 +xref: PMID:11760965 +xref: PMID:12054223 +xref: PMID:2112744 +xref: PMID:270744 +xref: PMID:32628106 +xref: PMID:36748408 +xref: PMID:7520741 +xref: PMID:8123559 +xref: PMID:8186100 +xref: PMID:8590690 +xref: PMID:9103655 +xref: PMID:9336922 is_a: NCBITaxon:131567 ! cellular organisms [Term] id: NCBITaxon:2058185 name: Dictyosteliaceae +xref: GC_ID:1 +xref: PMID:29367151 is_a: NCBITaxon:2058949 ! Dictyosteliales [Term] id: NCBITaxon:2058949 name: Dictyosteliales +xref: GC_ID:1 +xref: PMID:29367151 is_a: NCBITaxon:33083 ! Dictyostelia +[Term] +id: NCBITaxon:207598 +name: Homininae +xref: GC_ID:1 +is_a: NCBITaxon:9604 ! Hominidae + [Term] id: NCBITaxon:2157 name: Archaea +xref: GC_ID:11 +xref: PMID:10425795 +xref: PMID:10425796 +xref: PMID:10425797 +xref: PMID:10490293 +xref: PMID:10843050 +xref: PMID:10939651 +xref: PMID:10939673 +xref: PMID:10939677 +xref: PMID:11211268 +xref: PMID:11321083 +xref: PMID:11321113 +xref: PMID:11411719 +xref: PMID:11540071 +xref: PMID:11541975 +xref: PMID:11542064 +xref: PMID:11542149 +xref: PMID:11760965 +xref: PMID:12054223 +xref: PMID:2112744 +xref: PMID:25527841 +xref: PMID:270744 +xref: PMID:32628106 +xref: PMID:36748408 +xref: PMID:8123559 +xref: PMID:8590690 +xref: PMID:9103655 +xref: PMID:9336922 is_a: NCBITaxon:131567 ! cellular organisms [Term] id: NCBITaxon:2605435 name: Evosea +xref: GC_ID:1 is_a: NCBITaxon:554915 ! Amoebozoa [Term] id: NCBITaxon:2611352 name: Discoba +xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:2684882 name: Zygnematophycidae +xref: GC_ID:1 is_a: NCBITaxon:131209 ! Zygnemophyceae [Term] id: NCBITaxon:2698737 name: Sar +xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:2759 name: Eukaryota +xref: GC_ID:1 +xref: PMID:23020233 +xref: PMID:30257078 is_a: NCBITaxon:131567 ! cellular organisms +[Term] +id: NCBITaxon:314146 +name: Euarchontoglires +xref: GC_ID:1 +xref: PMID:11214319 +xref: PMID:12082125 +xref: PMID:12878460 +xref: PMID:15522813 +is_a: NCBITaxon:1437010 ! Boreoeutheria + +[Term] +id: NCBITaxon:314293 +name: Simiiformes +xref: GC_ID:1 +is_a: NCBITaxon:376913 ! Haplorrhini + +[Term] +id: NCBITaxon:314295 +name: Hominoidea +xref: GC_ID:1 +is_a: NCBITaxon:9526 ! Catarrhini + [Term] id: NCBITaxon:3176 name: Zygnematales +xref: GC_ID:1 is_a: NCBITaxon:2684882 ! Zygnematophycidae [Term] id: NCBITaxon:3193 name: Embryophyta +xref: GC_ID:1 is_a: NCBITaxon:131221 ! Streptophytina [Term] id: NCBITaxon:32443 name: Teleostei +xref: GC_ID:1 is_a: NCBITaxon:41665 ! Neopterygii [Term] id: NCBITaxon:32523 name: Tetrapoda +xref: GC_ID:1 is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha [Term] id: NCBITaxon:32524 name: Amniota +xref: GC_ID:1 is_a: NCBITaxon:32523 ! Tetrapoda [Term] id: NCBITaxon:32525 name: Theria +xref: GC_ID:1 is_a: NCBITaxon:40674 ! Mammalia [Term] id: NCBITaxon:32561 name: Sauria +xref: GC_ID:1 is_a: NCBITaxon:8457 ! Sauropsida [Term] id: NCBITaxon:33083 name: Dictyostelia +xref: GC_ID:1 +xref: PMID:11062127 +xref: PMID:29367151 +xref: PMID:9342353 is_a: NCBITaxon:142796 ! Eumycetozoa [Term] id: NCBITaxon:33090 name: Viridiplantae +xref: GC_ID:1 +xref: PMID:16248873 +xref: PMID:30257078 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:3312 name: Coniferophyta +xref: GC_ID:1 is_a: NCBITaxon:1437180 ! Acrogymnospermae [Term] id: NCBITaxon:33154 name: Opisthokonta +xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:33208 name: Metazoa +xref: GC_ID:1 is_a: NCBITaxon:33154 ! Opisthokonta [Term] id: NCBITaxon:33213 name: Bilateria +xref: GC_ID:1 is_a: NCBITaxon:6072 ! Eumetazoa [Term] id: NCBITaxon:33317 name: Protostomia +xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria [Term] id: NCBITaxon:33511 name: Deuterostomia +xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria [Term] id: NCBITaxon:33630 name: Alveolata +xref: GC_ID:1 is_a: NCBITaxon:2698737 ! Sar [Term] id: NCBITaxon:33682 name: Euglenozoa +xref: GC_ID:1 is_a: NCBITaxon:2611352 ! Discoba [Term] id: NCBITaxon:3372 name: Gnetopsida +xref: GC_ID:1 is_a: NCBITaxon:1437180 ! Acrogymnospermae [Term] id: NCBITaxon:3378 name: Gnetales +xref: GC_ID:1 is_a: NCBITaxon:1445966 ! Gnetidae [Term] id: NCBITaxon:3398 name: Magnoliopsida +xref: GC_ID:1 +xref: PMID:25249442 is_a: NCBITaxon:58024 ! Spermatophyta [Term] id: NCBITaxon:34346 name: Schizosaccharomycetales +xref: GC_ID:1 is_a: NCBITaxon:147554 ! Schizosaccharomycetes [Term] id: NCBITaxon:35493 name: Streptophyta +xref: GC_ID:1 is_a: NCBITaxon:33090 ! Viridiplantae +[Term] +id: NCBITaxon:376913 +name: Haplorrhini +xref: GC_ID:1 +is_a: NCBITaxon:9443 ! Primates + [Term] id: NCBITaxon:38254 name: Glaucocystophyceae +xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:40674 name: Mammalia +xref: GC_ID:1 is_a: NCBITaxon:32524 ! Amniota [Term] id: NCBITaxon:41665 name: Neopterygii +xref: GC_ID:1 is_a: NCBITaxon:186623 ! Actinopteri [Term] id: NCBITaxon:436486 name: Dinosauria +xref: GC_ID:1 is_a: NCBITaxon:8492 ! Archosauria [Term] id: NCBITaxon:436489 name: Saurischia +xref: GC_ID:1 is_a: NCBITaxon:436486 ! Dinosauria [Term] id: NCBITaxon:436491 name: Theropoda +xref: GC_ID:1 is_a: NCBITaxon:436489 ! Saurischia [Term] id: NCBITaxon:436492 name: Coelurosauria +xref: GC_ID:1 is_a: NCBITaxon:436491 ! Theropoda [Term] id: NCBITaxon:451864 name: Dikarya +xref: GC_ID:1 +xref: PMID:15689432 +xref: PMID:16151185 +xref: PMID:17010206 +xref: PMID:17051209 +xref: PMID:17572334 is_a: NCBITaxon:4751 ! Fungi [Term] id: NCBITaxon:451866 name: Taphrinomycotina +xref: GC_ID:1 is_a: NCBITaxon:4890 ! Ascomycota [Term] id: NCBITaxon:4751 name: Fungi +xref: GC_ID:1 +xref: PMID:11062127 +xref: PMID:12684019 is_a: NCBITaxon:33154 ! Opisthokonta [Term] id: NCBITaxon:4890 name: Ascomycota +xref: GC_ID:1 +xref: PMID:17572334 is_a: NCBITaxon:451864 ! Dikarya [Term] id: NCBITaxon:4891 name: Saccharomycetes +xref: GC_ID:1 is_a: NCBITaxon:147537 ! Saccharomycotina [Term] id: NCBITaxon:4892 name: Saccharomycetales +xref: GC_ID:1 is_a: NCBITaxon:4891 ! Saccharomycetes [Term] id: NCBITaxon:4893 name: Saccharomycetaceae +xref: GC_ID:1 is_a: NCBITaxon:4892 ! Saccharomycetales [Term] id: NCBITaxon:4894 name: Schizosaccharomycetaceae +xref: GC_ID:1 is_a: NCBITaxon:34346 ! Schizosaccharomycetales [Term] id: NCBITaxon:4895 name: Schizosaccharomyces +xref: GC_ID:1 is_a: NCBITaxon:4894 ! Schizosaccharomycetaceae [Term] id: NCBITaxon:4896 name: Schizosaccharomyces pombe +xref: GC_ID:1 is_a: NCBITaxon:4895 ! Schizosaccharomyces [Term] id: NCBITaxon:4930 name: Saccharomyces +xref: GC_ID:1 is_a: NCBITaxon:4893 ! Saccharomycetaceae [Term] id: NCBITaxon:4932 name: Saccharomyces cerevisiae +xref: GC_ID:1 is_a: NCBITaxon:4930 ! Saccharomyces [Term] id: NCBITaxon:50557 name: Insecta +xref: GC_ID:1 is_a: NCBITaxon:6960 ! Hexapoda [Term] id: NCBITaxon:554915 name: Amoebozoa +xref: GC_ID:1 +xref: PMID:23020233 +xref: PMID:30257078 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:5782 name: Dictyostelium +xref: GC_ID:1 +xref: PMID:29367151 is_a: NCBITaxon:2058185 ! Dictyosteliaceae [Term] id: NCBITaxon:58023 name: Tracheophyta +xref: GC_ID:1 is_a: NCBITaxon:3193 ! Embryophyta [Term] id: NCBITaxon:58024 name: Spermatophyta +xref: GC_ID:1 is_a: NCBITaxon:78536 ! Euphyllophyta [Term] id: NCBITaxon:6072 name: Eumetazoa +xref: GC_ID:1 is_a: NCBITaxon:33208 ! Metazoa [Term] id: NCBITaxon:6656 name: Arthropoda +xref: GC_ID:1 is_a: NCBITaxon:88770 ! Panarthropoda [Term] id: NCBITaxon:6960 name: Hexapoda +xref: GC_ID:1 is_a: NCBITaxon:197562 ! Pancrustacea [Term] id: NCBITaxon:716545 name: saccharomyceta +xref: GC_ID:1 is_a: NCBITaxon:4890 ! Ascomycota [Term] id: NCBITaxon:7711 name: Chordata +xref: GC_ID:1 is_a: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:7742 name: Vertebrata +xref: GC_ID:1 is_a: NCBITaxon:89593 ! Craniata [Term] id: NCBITaxon:7776 name: Gnathostomata +xref: GC_ID:1 is_a: NCBITaxon:7742 ! Vertebrata [Term] id: NCBITaxon:78536 name: Euphyllophyta +xref: GC_ID:1 is_a: NCBITaxon:58023 ! Tracheophyta [Term] id: NCBITaxon:7898 name: Actinopterygii +xref: GC_ID:1 is_a: NCBITaxon:117571 ! Euteleostomi [Term] id: NCBITaxon:8287 name: Sarcopterygii +xref: GC_ID:1 is_a: NCBITaxon:117571 ! Euteleostomi [Term] id: NCBITaxon:8457 name: Sauropsida +xref: GC_ID:1 is_a: NCBITaxon:32524 ! Amniota [Term] id: NCBITaxon:8492 name: Archosauria +xref: GC_ID:1 is_a: NCBITaxon:1329799 ! Archelosauria [Term] id: NCBITaxon:8782 name: Aves +xref: GC_ID:1 is_a: NCBITaxon:436492 ! Coelurosauria [Term] id: NCBITaxon:88770 name: Panarthropoda +xref: GC_ID:1 is_a: NCBITaxon:1206794 ! Ecdysozoa [Term] id: NCBITaxon:89593 name: Craniata +xref: GC_ID:1 is_a: NCBITaxon:7711 ! Chordata +[Term] +id: NCBITaxon:9347 +name: Eutheria +xref: GC_ID:1 +is_a: NCBITaxon:32525 ! Theria + +[Term] +id: NCBITaxon:9443 +name: Primates +xref: GC_ID:1 +is_a: NCBITaxon:314146 ! Euarchontoglires + +[Term] +id: NCBITaxon:9526 +name: Catarrhini +xref: GC_ID:1 +is_a: NCBITaxon:314293 ! Simiiformes + +[Term] +id: NCBITaxon:9604 +name: Hominidae +xref: GC_ID:1 +is_a: NCBITaxon:314295 ! Hominoidea + +[Term] +id: NCBITaxon:9605 +name: Homo +xref: GC_ID:1 +is_a: NCBITaxon:207598 ! Homininae + +[Term] +id: NCBITaxon:9606 +name: Homo sapiens +xref: GC_ID:1 +is_a: NCBITaxon:9605 ! Homo + +[Term] +id: SO:0000001 +name: region +def: "A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids." [SO:ke] +is_a: SO:0000110 ! sequence_feature + +[Term] +id: SO:0000110 +name: sequence_feature +def: "Any extent of continuous biological sequence." [LAMHDI:mb, SO:ke] + +[Term] +id: SO:0000704 +name: gene +def: "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions." [SO:immuno_workshop] +comment: This term is mapped to MGED. Do not obsolete without consulting MGED ontology. A gene may be considered as a unit of inheritance. +xref: http://en.wikipedia.org/wiki/Gene "wiki" +is_a: SO:0001411 ! biological_region +relationship: member_of SO:0005855 ! gene_group + [Term] id: SO:0001260 name: sequence_collection +def: "A collection of discontinuous sequences." [SO:ke] + +[Term] +id: SO:0001411 +name: biological_region +def: "A region defined by its disposition to be involved in a biological process." [SO:cb] +is_a: SO:0000001 ! region + +[Term] +id: SO:0005855 +name: gene_group +def: "A collection of related genes." [SO:ma] +is_a: SO:0001411 ! biological_region [Term] id: UBERON:0000000 name: processual entity +def: "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity." [span:ProcessualEntity] +xref: BFO:0000003 disjoint_from: UBERON:0001062 ! anatomical entity -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000005 @@ -31925,9 +41589,44 @@ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000050 UBERON:0005726 ! part of chemosensory system relationship: RO:0002215 GO:0007606 ! capable of sensory perception of chemical stimulus +[Term] +id: UBERON:0000006 +name: islet of Langerhans +def: "The clusters of hormone-producing cells that are scattered throughout the pancreas." [MA:0000127, MESH:A03.734.414, MP:0005215] +xref: AAO:0010406 +xref: BTO:0000991 +xref: CALOHA:TS-0741 +xref: EFO:0000856 +xref: EMAPA:32927 +xref: EV:0100130 +xref: FMA:16016 +xref: GAID:324 +xref: MA:0000127 +xref: MAT:0000076 +xref: MESH:D007515 +xref: MIAA:0000076 +xref: NCIT:C12608 +xref: VHOG:0000646 +xref: Wikipedia:Islets_of_Langerhans +xref: XAO:0000159 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0034922 ! cell cluster +relationship: BFO:0000050 UBERON:0000016 ! part of endocrine pancreas +relationship: BFO:0000051 CL:0000168 ! has part insulin secreting cell +relationship: BFO:0000051 CL:0000172 ! has part somatostatin secreting cell +relationship: BFO:0000051 CL:0002067 ! has part type A enteroendocrine cell +relationship: RO:0002433 UBERON:0000016 ! endocrine pancreas + [Term] id: UBERON:0000009 name: submucosa +def: "A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]." [Wikipedia:Submucosa] +xref: BTO:0002107 +xref: FMA:85391 +xref: FMA:85392 +xref: NCIT:C13167 +xref: SCTID:68439008 +xref: Wikipedia:Submucosa is_a: UBERON:0004923 ! organ component layer relationship: BSPO:0001107 UBERON:0000344 ! mucosa relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -31936,13 +41635,58 @@ relationship: RO:0002473 UBERON:0002384 ! connective tissue [Term] id: UBERON:0000010 name: peripheral nervous system +def: "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GO:0007422] +xref: AAO:0000429 +xref: BAMS:PNS +xref: BILA:0000081 +xref: BIRNLEX:1111 +xref: BTO:0001028 +xref: CALOHA:TS-0808 +xref: EFO:0000891 +xref: EHDAA2:0001445 +xref: EHDAA:2893 +xref: EMAPA:16665 +xref: EV:0100335 +xref: FMA:9903 +xref: GAID:715 +xref: MA:0000218 +xref: MAT:0000338 +xref: MESH:D017933 +xref: MIAA:0000338 +xref: NCIT:C12465 +xref: neuronames:3232 +xref: SCTID:362292005 +xref: TAO:0000142 +xref: VHOG:0000399 +xref: Wikipedia:Peripheral_nervous_system +xref: XAO:0000178 +xref: ZFA:0000142 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0001016 ! part of nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000013 name: sympathetic nervous system +def: "The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]." [GO:0048485] +xref: AAO:0010487 +xref: BIRNLEX:2516 +xref: BTO:0001832 +xref: CALOHA:TS-2050 +xref: EFO:0000893 +xref: EHDAA2:0001971 +xref: EHDAA:3769 +xref: EMAPA:16985 +xref: FMA:9906 +xref: GAID:710 +xref: MA:0000225 +xref: MESH:D013564 +xref: MIAA:0000100 +xref: NCIT:C12795 +xref: SCTID:362484004 +xref: TAO:0001576 +xref: VHOG:0000384 +xref: Wikipedia:Sympathetic_nervous_system +xref: ZFA:0001576 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: RO:0002433 UBERON:0002410 ! autonomic nervous system @@ -31950,6 +41694,18 @@ relationship: RO:0002433 UBERON:0002410 ! autonomic nervous system [Term] id: UBERON:0000014 name: zone of skin +def: "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Skin] +xref: EHDAA:6530 +xref: EV:0100152 +xref: FMA:86166 +xref: GAID:933 +xref: MA:0000151 +xref: MAT:0000284 +xref: MESH:D012867 +xref: MIAA:0000284 +xref: SCTID:20795001 +xref: VHOG:0000860 +xref: Wikipedia:Skin is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034944 ! zone of organ relationship: BFO:0000050 UBERON:0002097 ! part of skin of body @@ -31959,14 +41715,78 @@ relationship: BFO:0000051 UBERON:0002067 ! has part dermis [Term] id: UBERON:0000015 name: non-material anatomical boundary +def: "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." [CARO:0000010] +comment: Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. +xref: AEO:0000192 +xref: CARO:0000010 +xref: FMA:50705 is_a: UBERON:0000466 ! immaterial anatomical entity -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 + +[Term] +id: UBERON:0000016 +name: endocrine pancreas +def: "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin." [GO:GO, http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000650 +xref: CALOHA:TS-1302 +xref: EFO:0002542 +xref: EMAPA:35305 +xref: EV:0100129 +xref: FMA:16018 +xref: MA:0001582 +xref: NCIT:C32509 +xref: SCTID:361339003 +xref: TAO:0001260 +xref: VHOG:0000049 +xref: Wikipedia:Islets_of_Langerhans +xref: ZFA:0001260 +is_a: UBERON:0000471 ! compound organ component +is_a: UBERON:0004119 ! endoderm-derived structure +relationship: BFO:0000050 UBERON:0000949 ! part of endocrine system +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: RO:0002202 UBERON:0003923 ! dorsal pancreatic bud +relationship: RO:0002215 GO:0030073 ! capable of insulin secretion +relationship: RO:0002215 GO:0070091 ! capable of glucagon secretion +relationship: RO:0002215 GO:0070253 ! capable of somatostatin secretion +relationship: RO:0002433 UBERON:0001264 ! pancreas +relationship: RO:0002473 UBERON:0000006 ! islet of Langerhans + +[Term] +id: UBERON:0000017 +name: exocrine pancreas +def: "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]." [GOC:GO, http://orcid.org/0000-0002-6601-2165] +xref: AAO:0010407 +xref: BTO:0000434 +xref: CALOHA:TS-1241 +xref: EMAPA:35328 +xref: EV:0100093 +xref: FMA:16017 +xref: MA:0002415 +xref: NCIT:C32546 +xref: SCTID:248202004 +xref: TAO:0001249 +xref: VHOG:0000048 +xref: Wikipedia:Exocrine_component_of_pancreas +xref: XAO:0000137 +xref: ZFA:0001249 +is_a: UBERON:0000409 ! serous gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005177 ! trunk region element +is_a: UBERON:0013765 ! digestive system element +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000051 UBERON:0001263 ! has part pancreatic acinus +relationship: BFO:0000051 UBERON:0007329 ! has part pancreatic duct +relationship: RO:0002202 UBERON:0003924 ! ventral pancreatic bud +relationship: RO:0002216 GO:0007586 ! capable of part of digestion +relationship: RO:0002433 UBERON:0001264 ! pancreas [Term] id: UBERON:0000018 name: compound eye +def: "A light sensing organ composed of ommatidia." [FB:gg, Wikipedia:Compound_eye] +xref: BTO:0001921 +xref: HAO:0000217 +xref: TGMA:0000024 +xref: Wikipedia:Compound_eye is_a: UBERON:0015165 ! multi-unit eye intersection_of: UBERON:0000970 ! eye intersection_of: RO:0002473 UBERON:0000971 ! ommatidium @@ -31976,6 +41796,21 @@ relationship: RO:0002473 UBERON:0000971 ! ommatidium [Term] id: UBERON:0000019 name: camera-type eye +def: "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid." [GO:0043010, https://orcid.org/0000-0002-6601-2165] +xref: AAO:0010340 +xref: BIRNLEX:1169 +xref: BTO:0004688 +xref: EHDAA2:0000484 +xref: EHDAA:936 +xref: EMAPA:16198 +xref: FMA:54448 +xref: MA:0000261 +xref: NCIT:C12401 +xref: SCTID:181143004 +xref: TAO:0000107 +xref: VHOG:0000275 +xref: XAO:0000179 +xref: ZFA:0000107 is_a: UBERON:0000047 ! simple eye is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -31990,6 +41825,22 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0000020 name: sense organ +def: "An organ that is capable of transducing sensory stimulus to the nervous system." [https://github.com/obophenotype/uberon/issues/549, https://orcid.org/0000-0002-6601-2165] +xref: AEO:0000094 +xref: BSA:0000121 +xref: BTO:0000202 +xref: CALOHA:TS-2043 +xref: EHDAA2:0001824 +xref: EHDAA:500 +xref: EMAPA:35955 +xref: GAID:63 +xref: HAO:0000930 +xref: MA:0000017 +xref: MESH:D012679 +xref: NCIT:C33224 +xref: SCTID:244485009 +xref: VHOG:0001407 +xref: WBbt:0006929 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception @@ -31999,6 +41850,8 @@ relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved [Term] id: UBERON:0000025 name: tube +def: "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported." [http://orcid.org/0000-0002-6601-2165] +xref: galen:Tube is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: RO:0000086 PATO:0002299 @@ -32008,12 +41861,34 @@ relationship: RO:0000086 PATO:0002299 [Term] id: UBERON:0000026 name: appendage +def: "Major subdivision of an organism that protrudes from the body[DOS, CARO]." [CARO:DOS] +xref: AEO:0000193 +xref: BILA:0000018 +xref: BTO:0001492 +xref: CARO:0010003 +xref: EFO:0000799 +xref: EHDAA2:0003193 +xref: EV:0100155 +xref: HAO:0000144 +xref: MAT:0000023 +xref: MESH:D005121 +xref: MIAA:0000023 +xref: NCIT:C61460 +xref: VSAO:0000075 +xref: Wikipedia:Appendage +xref: XAO:0000218 is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0000030 name: lamina propria +def: "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions." [Wikipedia:Lamina_propria] +xref: BTO:0002330 +xref: FMA:62517 +xref: NCIT:C32918 +xref: SCTID:298225002 +xref: Wikipedia:Lamina_propria is_a: UBERON:0004923 ! organ component layer relationship: BFO:0000050 UBERON:0000344 ! part of mucosa relationship: BSPO:0001107 UBERON:0000483 ! epithelium @@ -32022,6 +41897,11 @@ relationship: RO:0002473 UBERON:0011825 ! loose connective tissue [Term] id: UBERON:0000031 name: lamina propria of trachea +def: "A lamina propria that is part of a respiratory airway." [OBOL:automatic] +xref: EMAPA:35877 +xref: FMA:265157 +xref: MA:0001858 +xref: NCIT:C49305 is_a: UBERON:0004779 ! respiratory system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001005 ! part of respiratory airway @@ -32030,6 +41910,34 @@ relationship: BFO:0000050 UBERON:0000379 ! part of tracheal mucosa [Term] id: UBERON:0000033 name: head +def: "The head is the anterior-most division of the body [GO]." [GO:0060322, Wikipedia:Head] +xref: AAO:0010335 +xref: AEO:0000106 +xref: BILA:0000115 +xref: BIRNLEX:1230 +xref: BTO:0000282 +xref: CALOHA:TS-0436 +xref: EFO:0000964 +xref: EHDAA2:0003106 +xref: EMAPA:31858 +xref: FMA:7154 +xref: GAID:61 +xref: galen:Head +xref: HAO:0000397 +xref: MA:0000023 +xref: MAT:0000294 +xref: MESH:D006257 +xref: MIAA:0000294 +xref: NCIT:C12419 +xref: SCTID:302548004 +xref: SPD:0000016 +xref: TAO:0001114 +xref: TGMA:0000002 +xref: VHOG:0001644 +xref: WBbt:0005739 +xref: Wikipedia:Head +xref: XAO:0003024 +xref: ZFA:0001114 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region relationship: RO:0002160 NCBITaxon:33213 ! Bilateria @@ -32038,6 +41946,15 @@ relationship: RO:0002551 UBERON:0003129 {gci_filler="NCBITaxon:7776", gci_relati [Term] id: UBERON:0000042 name: serous membrane +def: "Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Serous_membrane] +xref: FMA:9581 +xref: GAID:19 +xref: MESH:D012704 +xref: NCIT:C13169 +xref: SCTID:362878009 +xref: TAO:0005425 +xref: Wikipedia:Serous_membrane +xref: ZFA:0005425 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000060 ! part of anatomical wall @@ -32047,6 +41964,25 @@ relationship: BFO:0000051 UBERON:0002384 ! has part connective tissue [Term] id: UBERON:0000043 name: tendon +def: "Dense regular connective tissue that connects muscle to bone[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000073, Wikipedia:Tendon] +xref: AEO:0000091 +xref: BTO:0001356 +xref: CALOHA:TS-1021 +xref: EHDAA2:0003091 +xref: EMAPA:35854 +xref: EV:0100149 +xref: FMA:9721 +xref: GAID:276 +xref: galen:Tendon +xref: MA:0000115 +xref: MESH:D013710 +xref: NCIT:C13045 +xref: SCTID:256667004 +xref: VHOG:0001286 +xref: VSAO:0000073 +xref: Wikipedia:Tendon +xref: XAO:0000173 +xref: ZFA:0005647 is_a: UBERON:0007846 ! dense regular connective tissue relationship: BFO:0000050 UBERON:0002204 ! part of musculoskeletal system relationship: BFO:0000051 CL:0000327 ! has part extracellular matrix secreting cell @@ -32057,35 +41993,108 @@ relationship: RO:0002176 UBERON:0001630 ! muscle organ [Term] id: UBERON:0000045 name: ganglion +def: "A biological tissue mass, most commonly a mass of nerve cell bodies." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Ganglion] +xref: AAO:0010426 +xref: AEO:0000135 +xref: BAMS:G +xref: BTO:0000497 +xref: CALOHA:TS-0397 +xref: EFO:0000899 +xref: EHDAA2:0003135 +xref: EHDAA:2897 +xref: EHDAA:4662 +xref: EHDAA:5621 +xref: EHDAA:918 +xref: EMAPA:32846 +xref: EV:0100372 +xref: FMA:5884 +xref: MA:0002406 +xref: MAT:0000207 +xref: MAT:0000343 +xref: MESH:D005724 +xref: MIAA:0000207 +xref: MIAA:0000343 +xref: NCIT:C12719 +xref: NLXANAT:100302 +xref: TAO:0000190 +xref: TGMA:0001016 +xref: VHOG:0000156 +xref: WBbt:0005189 +xref: Wikipedia:Ganglion +xref: XAO:0000209 +xref: ZFA:0000190 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002473 UBERON:0003714 ! neural tissue relationship: RO:0002495 UBERON:0003869 ! presumptive ganglion -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000047 name: simple eye +def: "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity." [Wikipedia:Eye#Simple_eyes] +xref: TGMA:0000729 +xref: Wikipedia:Eye#Simple_eyes is_a: UBERON:0000970 ! eye [Term] id: UBERON:0000055 name: vessel +def: "A tubular structure that contains, conveys body fluid, such as blood or lymph." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0004111 ! anatomical conduit relationship: channel_for UBERON:0006314 ! bodily fluid -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000058 name: duct +def: "A tubular structure that transports secreted or excreted substances." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm#ducts] +xref: AAO:0011123 +xref: FMA:30320 +xref: galen:Duct +xref: NCIT:C12948 +xref: SCTID:91726008 +xref: TAO:0005171 +xref: Wikipedia:Duct_(anatomy) +xref: XAO:0004000 +xref: ZFA:0005171 is_a: UBERON:0000063 ! organ subunit relationship: BFO:0000051 UBERON:0034969 ! has part epithelial layer of duct relationship: RO:0000086 PATO:0002299 relationship: RO:0002570 UBERON:0000463 ! organism substance +[Term] +id: UBERON:0000059 +name: large intestine +def: "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]." [ISBN:0073040584, Wikipedia:Large_intestine_(anatomy)] +xref: AAO:0010396 +xref: BTO:0000706 +xref: CALOHA:TS-1306 +xref: EFO:0000840 +xref: EMAPA:19252 +xref: EV:0100077 +xref: FMA:7201 +xref: GAID:306 +xref: galen:LargeIntestine +xref: MA:0000333 +xref: MESH:D007420 +xref: MIAA:0000046 +xref: NCIT:C12379 +xref: SCTID:181254001 +xref: VHOG:0000054 +xref: Wikipedia:Large_intestine_(anatomy) +xref: XAO:0000131 +is_a: UBERON:0004921 ! subdivision of digestive tract +is_a: UBERON:0013765 ! digestive system element +relationship: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0004907 ! part of lower digestive tract +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002433 UBERON:0000160 ! intestine + [Term] id: UBERON:0000060 name: anatomical wall +def: "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers." [FMA:82482] +xref: FMA:82482 +xref: galen:Wall is_a: UBERON:0000064 ! organ part relationship: BFO:0000051 UBERON:0004923 ! has part organ component layer relationship: RO:0002220 UBERON:0002553 ! adjacent to anatomical cavity @@ -32093,52 +42102,98 @@ relationship: RO:0002220 UBERON:0002553 ! adjacent to anatomical cavity [Term] id: UBERON:0000061 name: anatomical structure +def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." [CARO:0000003] +xref: AAO:0010825 +xref: AEO:0000003 +xref: BILA:0000003 +xref: CARO:0000003 +xref: EHDAA2:0003003 +xref: EMAPA:0 +xref: FMA:305751 +xref: FMA:67135 +xref: GAID:781 +xref: HAO:0000003 +xref: http://dbpedia.org/ontology/AnatomicalStructure +xref: MA:0003000 +xref: MESH:D000825 +xref: SCTID:362889002 +xref: TAO:0000037 +xref: TGMA:0001823 +xref: VHOG:0001759 +xref: XAO:0003000 +xref: ZFA:0000037 is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002496 UBERON:0000106 {gci_filler="NCBITaxon:33208", gci_relation="RO:0002162"} ! zygote stage relationship: RO:0002497 UBERON:0000071 ! death stage -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000062 name: organ +def: "Anatomical structure that performs a specific function or group of functions [WP]." [Wikipedia:Organ_(anatomy)] +xref: BIRNLEX:4 +xref: CARO:0020004 +xref: EFO:0000634 +xref: EMAPA:35949 +xref: ENVO:01000162 +xref: FMA:67498 +xref: MA:0003001 +xref: NCIT:C13018 +xref: SCTID:272625005 +xref: WBbt:0003760 +xref: Wikipedia:Organ_(anatomy) is_a: UBERON:0010000 ! multicellular anatomical structure disjoint_from: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0000467 ! part of anatomical system relationship: RO:0002002 UBERON:0006984 ! anatomical surface relationship: RO:0002215 GO:0008150 ! capable of biological_process relationship: RO:0002496 UBERON:0000111 {gci_filler="NCBITaxon:6072", gci_relation="RO:0002162"} ! organogenesis stage -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000063 name: organ subunit +def: "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:86140 is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0000064 name: organ part +def: "A multicellular structure that is a part of an organ." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0011124 +xref: BIRNLEX:16 +xref: EFO:0000635 +xref: FMA:82472 +xref: SCTID:113343008 +xref: SCTID:91717005 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000062 ! part of organ -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000065 name: respiratory tract +def: "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts." [https://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0001606 +xref: EHDAA:1568 +xref: EHDAA:2219 +xref: EMAPA:16737 +xref: FMA:265130 +xref: SCTID:361110005 +xref: VHOG:0000393 is_a: UBERON:0001005 ! respiratory airway is_a: UBERON:0004119 ! endoderm-derived structure relationship: RO:0002202 UBERON:0007026 ! presumptive gut relationship: RO:0002202 UBERON:0008947 ! respiratory primordium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000066 name: fully formed stage +def: "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage." [https://orcid.org/0000-0002-6601-2165] +xref: BilaDO:0000004 +xref: BTO:0001043 +xref: EFO:0001272 +xref: FBdv:00005369 +xref: WBls:0000041 +xref: XtroDO:0000084 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000092 ! part of post-embryonic stage @@ -32148,6 +42203,20 @@ relationship: BFO:0000063 UBERON:0000071 ! precedes death stage [Term] id: UBERON:0000068 name: embryo stage +def: "A life cycle stage that starts with fertilization and ends with the fully formed embryo." [http://orcid.org/0000-0002-6601-2165] +xref: BilaDO:0000002 +xref: EV:0300001 +xref: FBdv:00005289 +xref: FMA:72652 +xref: HsapDv:0000002 +xref: MmusDv:0000002 +xref: OGES:000000 +xref: OGES:000022 +xref: SCTID:296280003 +xref: WBls:0000003 +xref: WBls:0000092 +xref: WBls:0000102 +xref: XAO:1000012 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage disjoint_from: UBERON:0000092 ! post-embryonic stage @@ -32158,16 +42227,19 @@ relationship: RO:0002082 GO:0009790 ! embryo development [Term] id: UBERON:0000071 name: death stage +def: "End of the life of an organism." [XAO:0000437] +xref: XAO:0000437 +xref: XtroDO:0000085 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: RO:0002229 UBERON:0000104 ! life cycle -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000072 name: proximo-distal subdivision of respiratory tract +def: "An section of a respiratory tract." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:45660 +xref: MA:0000434 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube @@ -32177,6 +42249,10 @@ relationship: BFO:0000050 UBERON:0000065 ! part of respiratory tract [Term] id: UBERON:0000073 name: regional part of nervous system +def: "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS." [BIRNLEX:1157] +xref: BIRNLEX:1157 +xref: NCIT:C13040 +xref: SCTID:25087005 is_a: UBERON:0000481 ! multi-tissue structure intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system @@ -32185,6 +42261,11 @@ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system [Term] id: UBERON:0000075 name: subdivision of skeletal system +def: "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: FMA:85544 +xref: galen:ComplexSkeletalStructure +xref: NCIT:C34076 +xref: SCTID:118966000 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0001434 ! part of skeletal system relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -32193,6 +42274,18 @@ relationship: RO:0002473 UBERON:0004765 ! skeletal element [Term] id: UBERON:0000076 name: external ectoderm +def: "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm." [MGI:anna, MP:0012532] +xref: EHDAA2:0001968 +xref: EHDAA:1494 +xref: EHDAA:350 +xref: EHDAA:4784 +xref: EHDAA:4790 +xref: EHDAA:4796 +xref: EHDAA:7860 +xref: EMAPA:16096 +xref: FMA:87656 +xref: NCIT:C34309 +xref: Wikipedia:External_ectoderm is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm @@ -32200,6 +42293,7 @@ relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm [Term] id: UBERON:0000077 name: mixed endoderm/mesoderm-derived structure +def: "An anatomical structure that develops from the endoderm and the mesoderm." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000061 ! anatomical structure @@ -32209,6 +42303,7 @@ intersection_of: RO:0002202 UBERON:0000926 ! mesoderm [Term] id: UBERON:0000078 name: mixed ectoderm/mesoderm/endoderm-derived structure +def: "An anatomical structure that develops from the ectoderm, mesoderm and endoderm." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000061 ! anatomical structure @@ -32219,6 +42314,15 @@ intersection_of: RO:0002202 UBERON:0000926 ! mesoderm [Term] id: UBERON:0000085 name: morula +def: "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [MP:0012130] +xref: BTO:0001508 +xref: EHDAA2:0000005 +xref: FMA:292334 +xref: GAID:1295 +xref: MESH:D009028 +xref: NCIT:C34212 +xref: SCTID:361474003 +xref: Wikipedia:Morula is_a: UBERON:0000922 ! embryo relationship: BFO:0000050 UBERON:0004716 ! part of conceptus relationship: BFO:0000051 CL:0000353 ! has part blastoderm cell @@ -32229,15 +42333,38 @@ relationship: RO:0002492 UBERON:0000107 ! cleavage stage [Term] id: UBERON:0000086 name: zona pellucida +def: "A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes." [Wikipedia:Zona_pellucida] +xref: BTO:0003135 +xref: EHDAA2:0002220 +xref: EHDAA:31 +xref: EHDAA:62 +xref: EMAPA:16035 +xref: FMA:18674 +xref: GAID:410 +xref: MA:0001715 +xref: MESH:D015044 +xref: NCIT:C33896 +xref: TAO:0001111 +xref: Wikipedia:Zona_pellucida +xref: ZFA:0001111 is_a: UBERON:0005764 ! acellular membrane relationship: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000051 CHEBI:17089 ! has part relationship: RO:0002007 CL:0000023 ! bounding layer of oocyte -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000087 name: inner cell mass +def: "A mass of cells that develop into the body of the embryo and some extraembryonic tissues." [ISBN:0-683-40008-8, MGI:pvb] +xref: EFO:0000547 +xref: EHDAA2:0000830 +xref: EHDAA:40 +xref: EMAPA:16041 +xref: FMA:86557 +xref: NCIT:C13740 +xref: SCTID:361456007 +xref: VHOG:0000742 +xref: Wikipedia:Inner_cell_mass is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0000358 ! blastocyst relationship: RO:0002219 UBERON:0000088 ! trophoblast @@ -32245,6 +42372,17 @@ relationship: RO:0002219 UBERON:0000088 ! trophoblast [Term] id: UBERON:0000088 name: trophoblast +def: "The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta." [ISBN:0-683-40008-8, MP:0005031] +comment: Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast] +xref: BTO:0001079 +xref: CALOHA:TS-1070 +xref: EV:0100120 +xref: FMA:83029 +xref: GAID:1152 +xref: MESH:D014327 +xref: NCIT:C93292 +xref: SCTID:362839005 +xref: Wikipedia:Trophoblast is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000358 ! part of blastocyst relationship: RO:0002202 UBERON:0004345 ! trophectoderm @@ -32253,12 +42391,24 @@ relationship: RO:0002473 CL:0000351 ! trophoblast cell [Term] id: UBERON:0000091 name: bilaminar disc +def: "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc." [MP:0003886] +xref: FMA:293863 +xref: NCIT:C34112 +xref: Wikipedia:Bilaminar_disc is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0000087 ! inner cell mass [Term] id: UBERON:0000092 name: post-embryonic stage +def: "Stage succeeding embryo, including mature structure." [https://orcid.org/0000-0002-6601-2165] +xref: BilaDO:0000003 +xref: OGES:000010 +xref: OGES:000014 +xref: OGES:000024 +xref: WBls:0000022 +xref: WBls:0000093 +xref: WBls:0000103 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000062 UBERON:0000068 ! preceded by embryo stage @@ -32267,12 +42417,19 @@ relationship: RO:0002082 GO:0009791 ! post-embryonic development [Term] id: UBERON:0000094 name: membrane organ +def: "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]." [FMA:7145] +xref: FMA:7145 is_a: UBERON:0000062 ! organ relationship: RO:0002473 UBERON:0011823 ! dense connective tissue [Term] id: UBERON:0000095 name: cardiac neural crest +def: "Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]." [Wikipedia:Cardiac_neural_crest] +xref: TAO:0002173 +xref: Wikipedia:Cardiac_neural_crest +xref: XAO:0004190 +xref: ZFA:0001648 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0002342 ! part of neural crest @@ -32281,6 +42438,13 @@ relationship: RO:0002131 UBERON:0005428 ! overlaps vagal neural crest [Term] id: UBERON:0000101 name: lobe of lung +def: "A lung lobe is one of the rounded projections that compose the lung[GO]." [GOC:GO] +xref: EMAPA:36281 +xref: FMA:7311 +xref: galen:LobeOfLung +xref: MA:0003098 +xref: NCIT:C34021 +xref: SCTID:245524004 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0009912 ! anatomical lobe relationship: BFO:0000050 UBERON:0002048 ! part of lung @@ -32289,6 +42453,8 @@ relationship: RO:0002433 UBERON:0002048 ! lung [Term] id: UBERON:0000102 name: lung vasculature +def: "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]." [GOC:GO] +xref: FMA:73750 is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature @@ -32298,27 +42464,54 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: UBERON:0000104 name: life cycle +def: "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism." [https://orcid.org/0000-0002-6601-2165] +xref: FBdv:00000000 +xref: HsapDv:0000001 +xref: MmusDv:0000001 +xref: ncithesaurus:Life +xref: OGES:000011 is_a: BFO:0000003 is_a: UBERON:0000000 ! processual entity relationship: BFO:0000051 UBERON:0000105 ! has part life cycle stage relationship: RO:0002224 UBERON:0000106 {gci_filler="NCBITaxon:33208", gci_relation="RO:0002162"} ! starts with zygote stage relationship: RO:0002230 UBERON:0000071 ! ends with death stage -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000105 name: life cycle stage +def: "A spatiotemporal region encompassing some part of the life cycle of an organism." [https://orcid.org/0000-0002-6601-2165] +xref: BILS:0000105 +xref: EFO:0000399 +xref: FBdv:00007012 +xref: FMA:24120 +xref: HsapDv:0000000 +xref: MESH:D008018 +xref: MmusDv:0000000 +xref: ncithesaurus:Developmental_Stage +xref: OlatDv:0000010 +xref: PdumDv:0000090 +xref: WBls:0000002 +xref: XAO:1000000 +xref: ZFS:0000000 +xref: ZFS:0100000 is_a: UBERON:0000000 ! processual entity relationship: BFO:0000050 UBERON:0000104 ! part of life cycle -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000106 name: zygote stage +def: "A stage at which the organism is a single cell produced by means of sexual reproduction." [Wikipedia:Zygote] +xref: BilaDO:0000005 +xref: BILS:0000106 +xref: EFO:0001322 +xref: EHDAA:27 +xref: FBdv:00005288 +xref: NCIT:C12601 +xref: PdumDv:0000100 +xref: VHOG:0000745 +xref: Wikipedia:Zygote +xref: XAO:1000001 +xref: ZFS:0000001 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage @@ -32327,6 +42520,19 @@ relationship: RO:0002223 UBERON:0000104 ! life cycle [Term] id: UBERON:0000107 name: cleavage stage +def: "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula." [GO:0040016, Wikipedia:Cleavage_(embryo)] +xref: BilaDO:0000006 +xref: BILS:0000107 +xref: EFO:0001290 +xref: FBdv:00000054 +xref: MESH:D002970 +xref: MmusDv:0000004 +xref: OGES:000015 +xref: OGES:000020 +xref: PdumDv:0000200 +xref: Wikipedia:Cleavage_(embryo) +xref: XAO:1000004 +xref: ZFS:0000046 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage intersection_of: UBERON:0000105 ! life cycle stage @@ -32338,6 +42544,19 @@ relationship: RO:0002087 UBERON:0000106 ! immediately preceded by zygote stage [Term] id: UBERON:0000108 name: blastula stage +def: "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [Wikipedia:Blastula] +xref: BilaDO:0000007 +xref: BILS:0000108 +xref: EFO:0001282 +xref: HsapDv:0000006 +xref: MmusDv:0000007 +xref: OGES:000003 +xref: OGES:000016 +xref: OGES:000021 +xref: WBls:0000005 +xref: Wikipedia:Blastula +xref: XAO:1000003 +xref: ZFS:0000045 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage @@ -32346,6 +42565,18 @@ relationship: BFO:0000062 UBERON:0000107 ! preceded by cleavage stage [Term] id: UBERON:0000109 name: gastrula stage +def: "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GO:0007369] +xref: BilaDO:0000008 +xref: BILS:0000109 +xref: EFO:0001296 +xref: FBdv:00005317 +xref: HsapDv:0000010 +xref: MmusDv:0000013 +xref: OGES:000004 +xref: OGES:000019 +xref: WBls:0000010 +xref: XAO:1000005 +xref: ZFS:0000047 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage @@ -32356,6 +42587,12 @@ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0000110 name: neurula stage +def: "Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GO:0001841] +xref: BilaDO:0000009 +xref: BILS:0000110 +xref: HsapDv:0000012 +xref: MmusDv:0000017 +xref: XAO:1000006 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage @@ -32366,6 +42603,14 @@ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0000111 name: organogenesis stage +def: "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism." [Wikipedia:Organogenesis] +xref: BilaDO:0000010 +xref: BILS:0000111 +xref: HsapDv:0000015 +xref: MmusDv:0000018 +xref: OGES:000005 +xref: OGES:000032 +xref: Wikipedia:Organogenesis is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage @@ -32376,6 +42621,11 @@ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0000114 name: lung connective tissue +def: "The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin." [ISBN:0-683-40008-8, MGI:anna, MP:0002276, PMID:14635660] +xref: EMAPA:35521 +xref: FMA:27533 +xref: MA:0001782 +xref: SCTID:201609008 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003580 ! lower respiratory tract connective tissue is_a: UBERON:0003837 ! thoracic segment connective tissue @@ -32384,11 +42634,14 @@ intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002433 UBERON:0002048 ! lung relationship: RO:0002494 UBERON:0004883 ! lung mesenchyme -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000115 name: lung epithelium +def: "The epithelial layer of the lung." [MP:0006382] +xref: BTO:0001653 +xref: EMAPA:32860 +xref: MA:0001783 is_a: UBERON:0004815 ! lower respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -32399,6 +42652,8 @@ relationship: RO:0002433 UBERON:0002048 ! lung [Term] id: UBERON:0000117 name: respiratory tube +def: "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea." [GO:0030323, http://orcid.org/0000-0002-6601-2165] +xref: FMA:12224 is_a: UBERON:0000025 ! tube is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000025 ! tube @@ -32409,6 +42664,13 @@ relationship: BFO:0000051 UBERON:0000483 ! has part epithelium [Term] id: UBERON:0000118 name: lung bud +def: "Structure derived from foregut that becomes a lung[GO]." [GO:0060431, Wikipedia:Respiratory_bud] +xref: BTO:0001643 +xref: EHDAA2:0004089 +xref: NCIT:C34260 +xref: NCIT:C34282 +xref: SCTID:361427007 +xref: Wikipedia:Respiratory_bud is_a: UBERON:0005153 ! epithelial bud is_a: UBERON:0005911 ! endo-epithelium relationship: RO:0002202 UBERON:0005597 ! lung primordium @@ -32418,6 +42680,9 @@ relationship: RO:0002220 UBERON:0004872 ! adjacent to splanchnic layer of latera [Term] id: UBERON:0000122 name: neuron projection bundle +def: "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." [CARO:0001001, FBbt:00005099, FBC:DOS] +xref: CARO:0001001 +xref: NLX:147821 is_a: UBERON:0005162 ! multi cell part structure relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000051 GO:0043005 ! has part neuron projection @@ -32425,6 +42690,12 @@ relationship: BFO:0000051 GO:0043005 ! has part neuron projection [Term] id: UBERON:0000125 name: neural nucleus +def: "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO)." [NLX:28443] +xref: AEO:0000136 +xref: FMA:83686 +xref: NCIT:C13197 +xref: NLX:28443 +xref: Wikipedia:Nucleus_(neuroanatomy) is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: RO:0002160 NCBITaxon:7711 ! Chordata relationship: RO:0002473 UBERON:0002020 ! gray matter @@ -32432,6 +42703,11 @@ relationship: RO:0002473 UBERON:0002020 ! gray matter [Term] id: UBERON:0000126 name: cranial nerve nucleus +def: "Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves." [NLX:28532] +xref: FMA:54501 +xref: NLX:28532 +xref: SCTID:280160003 +xref: Wikipedia:Cranial_nerve_nucleus is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: extends_fibers_into UBERON:0001785 ! cranial nerve @@ -32453,17 +42729,139 @@ relationship: RO:0002160 NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0000158 name: membranous layer +xref: FMA:30322 +xref: FMA:82500 +xref: MESH:D008566 +xref: NCIT:C12749 is_a: UBERON:0004923 ! organ component layer relationship: RO:0002007 UBERON:0000064 ! bounding layer of organ part +[Term] +id: UBERON:0000159 +name: anal canal +def: "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus." [Wikipedia:Anal_canal] +xref: BTO:0001978 +xref: CALOHA:TS-2160 +xref: EMAPA:18256 +xref: FMA:15703 +xref: galen:AnalCanal +xref: MA:0000330 +xref: NCIT:C12375 +xref: SCTID:245438008 +xref: Wikipedia:Anal_canal +is_a: UBERON:0004111 ! anatomical conduit +is_a: UBERON:0004121 ! ectoderm-derived structure +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001353 ! part of anal region +relationship: channel_for UBERON:0001988 ! feces +relationship: RO:0002150 UBERON:0001052 ! rectum +relationship: RO:0002150 UBERON:0001245 ! anus +relationship: RO:0002202 UBERON:0011272 ! embryonic skin basal layer + +[Term] +id: UBERON:0000160 +name: intestine +def: "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine." [GOC:GO, Wikipedia:Intestine] +xref: AAO:0000246 +xref: ANISEED:1235303 +xref: BSA:0000093 +xref: BTO:0000648 +xref: CALOHA:TS-0490 +xref: EFO:0000834 +xref: EMAPA:32874 +xref: EV:0100071 +xref: FMA:7199 +xref: GAID:295 +xref: galen:Intestine +xref: MA:0000328 +xref: MA:0001524 +xref: MESH:D007422 +xref: MIAA:0000043 +xref: NCIT:C12736 +xref: SCTID:256876008 +xref: TAO:0001338 +xref: VHOG:0000056 +xref: WBbt:0005772 +xref: Wikipedia:Intestine +xref: XAO:0000129 +xref: ZFA:0001338 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system +relationship: RO:0002433 UBERON:0001007 ! digestive system + [Term] id: UBERON:0000161 name: orifice +def: "Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]." [FMA:3724] +xref: FMA:3724 +xref: SCTID:91837002 is_a: UBERON:0004111 ! anatomical conduit +[Term] +id: UBERON:0000162 +name: cloaca +def: "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures." [ISBN:0073040584, Wikipedia:Cloaca] +xref: AAO:0000095 +xref: GAID:1206 +xref: MESH:D002988 +xref: NCIT:C34127 +xref: SCTID:362857006 +xref: SCTID:370631000 +xref: VHOG:0001186 +xref: Wikipedia:Cloaca +xref: XAO:0000244 +xref: ZFA:0005781 +is_a: UBERON:0013522 ! subdivision of tube +relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract +relationship: BFO:0000050 UBERON:0004122 ! part of genitourinary system +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata + +[Term] +id: UBERON:0000163 +name: embryonic cloaca +def: "Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]." [MP:0010115, Wikipedia:Cloaca_(embryology)] +xref: EHDAA2:0000256 +xref: EHDAA:4895 +xref: EMAPA:27573 +xref: Wikipedia:Cloaca_(embryology) +is_a: UBERON:0000162 ! cloaca +relationship: BFO:0000050 UBERON:0000922 ! part of embryo +relationship: BFO:0000050 UBERON:0001008 ! part of renal system +relationship: BFO:0000050 UBERON:0012361 ! part of internal anal region +relationship: RO:0002254 UBERON:0003064 ! intermediate mesoderm + [Term] id: UBERON:0000165 name: mouth +def: "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract, Wikipedia:Mouth] +xref: AAO:0010355 +xref: BTO:0001090 +xref: BTO:0004698 +xref: CALOHA:TS-1315 +xref: EFO:0000825 +xref: EHDAA2:0001326 +xref: EHDAA:542 +xref: EMAPA:16262 +xref: FMA:49184 +xref: GAID:75 +xref: galen:Mouth +xref: http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg +xref: MA:0000341 +xref: MA:0002474 +xref: MAT:0000038 +xref: MESH:D009055 +xref: MIAA:0000038 +xref: SCTID:21082005 +xref: TADS:0000040 +xref: TAO:0000547 +xref: TAO:0000590 +xref: TGMA:0000131 +xref: VHOG:0000280 +xref: VHOG:0000812 +xref: Wikipedia:Mouth +xref: XAO:0003029 +xref: ZFA:0000547 +xref: ZFA:0000590 is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: BSPO:0001106 UBERON:0001555 ! digestive tract @@ -32474,6 +42872,8 @@ relationship: RO:0002202 UBERON:0035804 ! future mouth [Term] id: UBERON:0000166 name: oral opening +def: "The orifice that connects the mouth to the exterior of the body." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract] +xref: FMA:59806 is_a: UBERON:0000161 ! orifice relationship: BFO:0000050 UBERON:0000165 ! part of mouth relationship: RO:0002131 UBERON:0001004 {gci_filler="NCBITaxon:32523", gci_relation="BFO:0000050"} ! overlaps respiratory system @@ -32481,6 +42881,27 @@ relationship: RO:0002131 UBERON:0001004 {gci_filler="NCBITaxon:32523", gci_relat [Term] id: UBERON:0000167 name: oral cavity +def: "Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present)." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract, https://orcid.org/0000-0002-6601-2165, ISBN:0073040584] +xref: AAO:0000053 +xref: AAO:0000960 +xref: BSA:0000107 +xref: CALOHA:TS-1315 +xref: EFO:0001975 +xref: EHDAA2:0001324 +xref: EHDAA:6970 +xref: EMAPA:17411 +xref: EMAPA:18399 +xref: EV:0100057 +xref: FMA:20292 +xref: HAO:0000669 +xref: NCIT:C12421 +xref: SCTID:181220002 +xref: TAO:0001027 +xref: TGMA:0000102 +xref: VHOG:0000188 +xref: WBbt:0005255 +xref: XAO:0000126 +xref: ZFA:0001027 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000165 ! mouth @@ -32488,9 +42909,22 @@ relationship: BFO:0000050 UBERON:0000165 ! part of mouth relationship: RO:0002433 UBERON:0000165 ! mouth relationship: RO:0002572 UBERON:0000165 ! mouth +[Term] +id: UBERON:0000168 +name: proximal-distal subdivision of colon +def: "A section dividing a colon along a proximal-distal axis." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:222905 +is_a: UBERON:0004921 ! subdivision of digestive tract +intersection_of: UBERON:0013522 ! subdivision of tube +intersection_of: subdivision_of UBERON:0001155 ! colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon +relationship: subdivision_of UBERON:0001155 ! colon + [Term] id: UBERON:0000170 name: pair of lungs +def: "The pair of anatomical structures comprised of a left lung and right lung." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:68877 is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: RO:0002351 UBERON:0002167 ! right lung @@ -32501,40 +42935,128 @@ relationship: RO:0002351 UBERON:0002167 ! right lung relationship: RO:0002351 UBERON:0002167 {cardinality="1"} ! right lung relationship: RO:0002351 UBERON:0002168 ! left lung relationship: RO:0002351 UBERON:0002168 {cardinality="1"} ! left lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000171 name: respiration organ +def: "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [GO:0007585] +xref: SCTID:272626006 +xref: SPD:0000428 +xref: TGMA:0001247 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system +[Term] +id: UBERON:0000174 +name: excreta +def: "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity." [GO:0007588, http://orcid.org/0000-0002-6601-2165] +xref: AEO:0000184 +xref: BTO:0000491 +xref: EHDAA2_RETIRED:0003184 +xref: ENVO:02000022 +xref: FMA:9674 +xref: galen:Excretion +is_a: UBERON:0000463 ! organism substance +intersection_of: UBERON:0000463 ! organism substance +intersection_of: RO:0002353 GO:0007588 ! output of excretion +relationship: RO:0002353 GO:0007588 ! output of excretion + [Term] id: UBERON:0000178 name: blood +def: "A fluid that is composed of blood plasma and erythrocytes." [FMA:9670, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/9, Wikipedia:Blood] +xref: AAO:0000046 +xref: BTO:0000089 +xref: CALOHA:TS-0079 +xref: EFO:0000296 +xref: EHDAA2:0000176 +xref: EHDAA:418 +xref: EMAPA:16332 +xref: ENVO:02000027 +xref: EV:0100047 +xref: FMA:9670 +xref: GAID:965 +xref: galen:Blood +xref: MA:0000059 +xref: MESH:D001769 +xref: MIAA:0000315 +xref: NCIT:C12434 +xref: TAO:0000007 +xref: VHOG:0000224 +xref: Wikipedia:Blood +xref: XAO:0000124 +xref: ZFA:0000007 is_a: UBERON:0000179 ! haemolymphatic fluid relationship: BFO:0000050 UBERON:0002390 ! part of hematopoietic system relationship: BFO:0000051 CL:0000232 ! has part erythrocyte relationship: BFO:0000051 UBERON:0001969 ! has part blood plasma relationship: RO:0001025 UBERON:0002049 ! vasculature relationship: RO:0002495 UBERON:0006596 ! presumptive blood -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000179 name: haemolymphatic fluid +def: "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs." [http://orcid.org/0000-0002-6601-2165] +xref: CARO:0000081 is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system relationship: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa +[Term] +id: UBERON:0000209 +name: tetrapod frontal bone +def: "The bone forming the forehead and roof of the eye orbit." [ISBN:0-683-40008-8, MP:0000107, PMID:7914451, Wikipedia:Frontal_bone] +xref: AAO:0000206 +xref: EMAPA:19016 +xref: FMA:52734 +xref: GAID:226 +xref: MA:0001466 +xref: MESH:D005624 +xref: NCIT:C32635 +xref: SCTID:181793006 +xref: VSAO:0000208 +xref: Wikipedia:Frontal_bone +is_a: UBERON:0002514 ! intramembranous bone +is_a: UBERON:0008907 ! dermal bone +is_a: UBERON:0010428 ! flat bone +is_a: UBERON:0011164 ! neurocranium bone +relationship: BFO:0000050 UBERON:0003113 ! part of dermatocranium +relationship: RO:0002131 UBERON:0001697 ! overlaps orbit of skull + +[Term] +id: UBERON:0000220 +name: atlanto-occipital joint +def: "The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital." [Wikipedia:Atlanto-occipital_joint] +xref: FMA:24939 +xref: NCIT:C32158 +xref: ncithesaurus:Atlanto-occipital_Joint-Atlanto +xref: SCTID:361831006 +xref: Wikipedia:Atlanto-occipital_joint +is_a: UBERON:0002217 ! synovial joint +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0002217 ! synovial joint +intersection_of: RO:0002176 UBERON:0001092 ! vertebral bone 1 +intersection_of: RO:0002176 UBERON:0001676 ! occipital bone +relationship: BFO:0000050 UBERON:0011138 ! part of postcranial axial skeletal system +relationship: BSPO:0000126 UBERON:0006072 ! cervical region of vertebral column +relationship: RO:0002176 UBERON:0001092 ! vertebral bone 1 +relationship: RO:0002176 UBERON:0001676 ! occipital bone + [Term] id: UBERON:0000304 name: tendon sheath +def: "A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath." [Wikipedia:Tendon_sheath] +xref: BTO:0000051 +xref: FMA:45087 +xref: FMA:76715 +xref: NCIT:C96299 +xref: SCTID:361885006 +xref: Wikipedia:Tendon_sheath is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002007 UBERON:0000043 ! bounding layer of tendon @@ -32545,22 +43067,82 @@ relationship: RO:0002007 UBERON:0000043 ! bounding layer of tendon [Term] id: UBERON:0000307 name: blastula +def: "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [Wikipedia:Blastula] +xref: BILA:0000059 +xref: BTO:0000128 +xref: GAID:1294 +xref: MESH:D036703 +xref: OGEM:000006 +xref: Wikipedia:Blastula is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002491 UBERON:0000108 ! blastula stage relationship: RO:0002202 UBERON:0007010 ! cleaving embryo relationship: RO:0002491 UBERON:0000108 ! blastula stage +[Term] +id: UBERON:0000317 +name: colonic mucosa +def: "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000271 +xref: CALOHA:TS-0164 +xref: EFO:0003038 +xref: EMAPA:27375 +xref: FMA:14984 +xref: FMA:85388 +xref: MA:0003194 +xref: SCTID:362157008 +is_a: UBERON:0001207 ! mucosa of large intestine +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0000320 +name: duodenal mucosa +def: "A mucosa that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000367 +xref: CALOHA:TS-0213 +xref: EMAPA:27235 +xref: FMA:14942 +xref: MA:0003207 +xref: SCTID:362146003 +is_a: UBERON:0001204 ! mucosa of small intestine +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + [Term] id: UBERON:0000325 name: gastric gland +def: "The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin." [MGI:anna] +xref: BTO:0000503 +xref: EMAPA:27181 +xref: FMA:14919 is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003294 ! gland of foregut relationship: BFO:0000050 UBERON:0006924 ! part of stomach glandular epithelium +[Term] +id: UBERON:0000326 +name: pancreatic juice +def: "Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GO:0030157] +xref: BTO:0000504 +xref: CALOHA:TS-2235 +xref: FMA:62973 +xref: GAID:1166 +xref: MESH:D010189 +is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: RO:0003001 UBERON:0001264 ! produced by pancreas +relationship: RO:0003001 UBERON:0001264 ! produced by pancreas + [Term] id: UBERON:0000328 name: gut wall +def: "The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity)." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000547 +xref: FMA:45653 is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract @@ -32569,15 +43151,46 @@ relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: UBERON:0000332 name: yellow bone marrow +def: "Bone marrow in which the fat cells predominate in the meshes of the reticular network." [http://medical-dictionary.thefreedictionary.com/Yellow+Marrow] +xref: BTO:0000635 +xref: FMA:74596 +xref: SCTID:328639002 +xref: SCTID:5023006 is_a: UBERON:0002371 ! bone marrow intersection_of: UBERON:0002371 ! bone marrow intersection_of: RO:0002473 CL:0000136 ! adipocyte relationship: BFO:0000050 UBERON:0007195 ! part of stroma of bone marrow relationship: RO:0002473 CL:0000136 ! adipocyte +[Term] +id: UBERON:0000333 +name: intestinal gland +def: "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0000640 +xref: FMA:15052 +xref: SCTID:266297002 +is_a: UBERON:0003408 ! gland of digestive tract +intersection_of: UBERON:0002530 ! gland +intersection_of: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa +relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa + [Term] id: UBERON:0000344 name: mucosa +def: "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]." [Wikipedia:Mucous_membrane] +xref: AEO:0000199 +xref: BTO:0000886 +xref: CALOHA:TS-2031 +xref: EHDAA2_RETIRED:0003234 +xref: EV:0100382 +xref: FMA:85355 +xref: FMA:85358 +xref: GAID:297 +xref: galen:Mucosa +xref: MESH:D009092 +xref: NCIT:C13166 +xref: SCTID:361693009 +xref: Wikipedia:Mucous_membrane is_a: UBERON:0004923 ! organ component layer relationship: BFO:0000051 UBERON:0000483 ! has part epithelium relationship: BFO:0000051 UBERON:0002384 ! has part connective tissue @@ -32586,6 +43199,22 @@ relationship: RO:0002160 NCBITaxon:7711 ! Chordata [Term] id: UBERON:0000353 name: parenchyma +def: "Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues." [Wikipedia:Parenchyma] +xref: EHDAA:3015 +xref: EHDAA:3905 +xref: EHDAA:3999 +xref: EHDAA:4005 +xref: EHDAA:6899 +xref: EHDAA:6903 +xref: EHDAA:6994 +xref: EHDAA:8086 +xref: EHDAA:9182 +xref: EHDAA:9190 +xref: EHDAA:9196 +xref: EHDAA:9202 +xref: FMA:45732 +xref: NCIT:C74601 +xref: Wikipedia:Parenchyma is_a: UBERON:0000064 ! organ part disjoint_from: UBERON:0003891 ! stroma relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa @@ -32594,6 +43223,12 @@ relationship: RO:0002215 GO:0032501 ! capable of multicellular organismal proces [Term] id: UBERON:0000355 name: pharyngeal mucosa +def: "A mucosa that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001047 +xref: EMAPA:26957 +xref: FMA:55031 +xref: MA:0003143 +xref: SCTID:362121003 is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx @@ -32602,6 +43237,18 @@ relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx [Term] id: UBERON:0000358 name: blastocyst +def: "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]." [GO:0001824, Wikipedia:Blastocyst] +xref: BTO:0001099 +xref: CALOHA:TS-0076 +xref: EFO:0000295 +xref: EMAPA:36035 +xref: EV:0100394 +xref: FMA:83041 +xref: GAID:1153 +xref: MESH:D001755 +xref: NCIT:C13739 +xref: SCTID:308837009 +xref: Wikipedia:Blastocyst is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000307 ! part of blastula relationship: BFO:0000051 UBERON:0000087 ! has part inner cell mass @@ -32613,6 +43260,11 @@ relationship: RO:0002491 UBERON:0000108 ! blastula stage [Term] id: UBERON:0000361 name: red bone marrow +def: "The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream." [http://medical-dictionary.thefreedictionary.com/red+marrow] +xref: BTO:0001160 +xref: FMA:74595 +xref: SCTID:328538003 +xref: SCTID:75330005 is_a: UBERON:0002371 ! bone marrow intersection_of: UBERON:0002371 ! bone marrow intersection_of: RO:0002473 CL:0000988 ! hematopoietic cell @@ -32622,6 +43274,15 @@ relationship: RO:0002473 CL:0000988 ! hematopoietic cell [Term] id: UBERON:0000371 name: syncytiotrophoblast +def: "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated)." [http://embryology.med.unsw.edu.au/Notes/placenta5.htm, Wikipedia:Syncytiotrophoblast] +xref: BTO:0001335 +xref: EHDAA:129 +xref: EHDAA:91 +xref: EMAPA:16068 +xref: FMA:83040 +xref: NCIT:C33918 +xref: SCTID:256965005 +xref: Wikipedia:Syncytiotrophoblast is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004364 ! part of ectoplacental cone relationship: RO:0002473 CL:0000525 ! syncytiotrophoblast cell @@ -32629,13 +43290,28 @@ relationship: RO:0002473 CL:0000525 ! syncytiotrophoblast cell [Term] id: UBERON:0000377 name: maxillary nerve +def: "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses." [MP:0009799, Wikipedia:Maxillary_nerve] +xref: AAO:0010670 +xref: BTO:0001378 +xref: EHDAA2:0002087 +xref: EMAPA:17799 +xref: FMA:52724 +xref: GAID:836 +xref: MA:0001103 +xref: MESH:D008442 +xref: SCTID:280211001 +xref: VHOG:0001346 +xref: Wikipedia:Maxillary_nerve is_a: UBERON:0011779 ! nerve of head region relationship: RO:0002380 UBERON:0001645 ! trigeminal nerve -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000379 name: tracheal mucosa +def: "A mucosa that is part of a respiratory airway." [OBOL:automatic] +xref: BTO:0001390 +xref: FMA:7471 +xref: SCTID:660006 is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001005 ! part of respiratory airway @@ -32644,17 +43320,34 @@ relationship: BFO:0000050 UBERON:0001005 ! part of respiratory airway [Term] id: UBERON:0000383 name: musculature of body +def: "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]." [VSAO:0000033] +xref: AAO:0000307 +xref: BILA:0000088 +xref: BTO:0001369 +xref: BTO:0001485 +xref: EFO:0000801 +xref: FMA:72954 +xref: MA:0002888 +xref: MAT:0000025 +xref: MIAA:0000025 +xref: VSAO:0000033 +xref: XAO:0004042 is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: RO:0002473 UBERON:0001015 ! musculature relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa relationship: RO:0002215 GO:0003012 ! capable of muscle system process relationship: RO:0002473 UBERON:0001015 ! musculature -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000389 name: lens cortex +def: "Tissue that surrounds the lens nucleus." [http://www.thefreedictionary.com/lens+cortex] +xref: BTO:0001632 +xref: CALOHA:TS-0542 +xref: FMA:58970 +xref: MESH:D007904 +xref: SCTID:280626006 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000479 ! tissue @@ -32662,11 +43355,15 @@ intersection_of: RO:0002221 UBERON:0000390 ! lens nucleus relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: RO:0002202 UBERON:0005614 ! lens anterior epithelium relationship: RO:0002221 UBERON:0000390 ! lens nucleus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000390 name: lens nucleus +def: "The core of the crystalline lens, surrounded by the cortex." [BTO:0001633] +xref: BTO:0001633 +xref: FMA:58971 +xref: MESH:D007907 +xref: SCTID:280628007 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034944 ! zone of organ intersection_of: UBERON:0034944 ! zone of organ @@ -32674,11 +43371,31 @@ intersection_of: RO:0002219 UBERON:0000389 ! lens cortex relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: RO:0002202 UBERON:0005614 ! lens anterior epithelium relationship: RO:0002219 UBERON:0000389 ! lens cortex -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0000397 +name: colonic epithelium +def: "An epithelium that is part of a colon [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001709 +xref: CALOHA:TS-0163 +xref: EMAPA:18941 +xref: FMA:17302 +xref: MA:0003195 +xref: SCTID:42978003 +xref: TAO:0005128 +xref: ZFA:0005128 +is_a: UBERON:0001278 ! epithelium of large intestine +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon [Term] id: UBERON:0000409 name: serous gland +def: "A gland in which the principal secretory cells are serous secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] +xref: BTO:0001837 +xref: FMA:62889 +xref: Wikipedia:Serous_gland is_a: UBERON:0002365 ! exocrine gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: BFO:0000051 CL:0000313 ! has part serous secreting cell @@ -32689,23 +43406,67 @@ relationship: RO:0003000 UBERON:0007794 ! produces secretion of serous gland [Term] id: UBERON:0000410 name: bronchial mucosa +def: "A mucosa that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001846 +xref: FMA:62652 +xref: SCTID:30802009 is_a: UBERON:0000379 ! tracheal mucosa is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus +[Term] +id: UBERON:0000414 +name: mucous gland +def: "A gland in which the principal secretory cells are mucus secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] +xref: AAO:0010601 +xref: BTO:0001979 +xref: FMA:62888 +xref: Wikipedia:Mucous_gland +is_a: UBERON:0002365 ! exocrine gland +intersection_of: UBERON:0002365 ! exocrine gland +intersection_of: BFO:0000051 CL:0000319 ! has part mucus secreting cell +relationship: BFO:0000051 CL:0000319 ! has part mucus secreting cell +relationship: RO:0002215 GO:0070254 ! capable of mucus secretion +relationship: RO:0003000 UBERON:0000912 ! produces mucus + [Term] id: UBERON:0000415 name: artery wall +def: "An anatomical wall that is part of an artery [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0002009 +xref: FMA:14155 +xref: galen:ArterialWall is_a: UBERON:0035965 ! wall of blood vessel intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0001637 ! part of artery +[Term] +id: UBERON:0000440 +name: trabecula +def: "A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]." [GO:0060343, Wikipedia:Trabecula] +xref: BTO:0002501 +xref: FMA:85273 +xref: Wikipedia:Trabecula +is_a: UBERON:0000064 ! organ part +relationship: BFO:0000051 UBERON:0002384 ! has part connective tissue +relationship: RO:0000086 PATO:0001873 + [Term] id: UBERON:0000456 name: secretion of exocrine gland +def: "A portion of organism substance that is produced by exocrine glands." [http://orcid.org/0000-0002-6601-2165] +xref: AEO:0001005 +xref: BTO:0002977 +xref: BTO:0002979 +xref: EMAPA:36535 +xref: FMA:9675 +xref: galen:Secretion +xref: MA:0002504 +xref: MESH:D012634 +xref: NCIT:C34062 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0002365 ! produced by exocrine gland @@ -32714,73 +43475,224 @@ relationship: RO:0003001 UBERON:0002365 ! produced by exocrine gland [Term] id: UBERON:0000463 name: organism substance +def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010839 +xref: AEO:0000004 +xref: BILA:0000004 +xref: CALOHA:TS-2101 +xref: CARO:0000004 +xref: EHDAA2:0003004 +xref: EMAPA:35178 +xref: FMA:9669 +xref: galen:BodySubstance +xref: HAO:0000004 +xref: MA:0002450 +xref: NCIT:C13236 +xref: SPD:0000008 +xref: TAO:0001487 +xref: TGMA:0001824 +xref: VHOG:0001726 +xref: XAO:0004001 +xref: ZFA:0001487 is_a: UBERON:0000465 ! material anatomical entity relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: RO:0000086 PATO:0002198 -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000464 name: anatomical space +def: "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010110 +xref: AEO:0000005 +xref: BILA:0000005 +xref: CARO:0000005 +xref: EHDAA2:0003005 +xref: FMA:5897 +xref: HAO:0000005 +xref: NCIT:C94478 +xref: TAO:0001668 +xref: TGMA:0001825 +xref: VHOG:0001728 +xref: XAO:0003190 +xref: ZFA:0001643 is_a: UBERON:0000466 ! immaterial anatomical entity relationship: RO:0002219 UBERON:0000061 ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000465 name: material anatomical entity +def: "Anatomical entity that has mass." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010264 +xref: AEO:0000006 +xref: BILA:0000006 +xref: CARO:0000006 +xref: EHDAA2:0003006 +xref: FMA:67165 +xref: HAO:0000006 +xref: TAO:0001836 +xref: TGMA:0001826 +xref: VHOG:0001721 is_a: BFO:0000040 is_a: UBERON:0001062 ! anatomical entity disjoint_from: UBERON:0000466 ! immaterial anatomical entity -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000466 name: immaterial anatomical entity +def: "Anatomical entity that has no mass." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010265 +xref: AEO:0000007 +xref: BILA:0000007 +xref: CARO:0000007 +xref: EHDAA2:0003007 +xref: FMA:67112 +xref: HAO:0000007 +xref: TAO:0001835 +xref: TGMA:0001827 +xref: VHOG:0001727 is_a: BFO:0000141 is_a: UBERON:0001062 ! anatomical entity -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000467 name: anatomical system +def: "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." [CARO:0000011] +xref: AAO:0000007 +xref: AEO:0000011 +xref: BILA:0000011 +xref: BIRNLEX:14 +xref: BSA:0000049 +xref: CALOHA:TS-2088 +xref: CARO:0000011 +xref: EHDAA2:0003011 +xref: EHDAA:392 +xref: EMAPA:16103 +xref: EV:0100000 +xref: FMA:7149 +xref: galen:AnatomicalSystem +xref: HAO:0000011 +xref: MA:0000003 +xref: NCIT:C12919 +xref: SCTID:278195005 +xref: TAO:0001439 +xref: TGMA:0001831 +xref: VHOG:0001725 +xref: WBbt:0005746 +xref: WBbt:0005763 +xref: Wikipedia:Organ_system +xref: XAO:0003002 +xref: ZFA:0001439 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: BFO:0000051 UBERON:0000062 ! has part organ relationship: RO:0002496 UBERON:0000111 {gci_filler="NCBITaxon:6072", gci_relation="RO:0002162"} ! organogenesis stage -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000468 name: multicellular organism +def: "Anatomical structure that is an individual member of a species and consists of more than one cell." [CARO:0000012, http://orcid.org/0000-0001-9114-8737, Wikipedia:Multi-cellular_organism] +xref: AAO:0010026 +xref: AEO:0000191 +xref: BILA:0000012 +xref: BIRNLEX:18 +xref: BSA:0000038 +xref: BTO:0000042 +xref: CARO:0000012 +xref: EFO:0002906 +xref: EHDAA2:0003103 +xref: EHDAA2:0003191 +xref: EHDAA:1 +xref: EMAPA:25765 +xref: EV:0100016 +xref: FMA:256135 +xref: galen:Organism +xref: HAO:0000012 +xref: NCIT:C13041 +xref: ncithesaurus:Whole_Organism +xref: SCTID:243928005 +xref: TADS:0000001 +xref: TAO:0001094 +xref: TGMA:0001832 +xref: VHOG:0000671 +xref: WBbt:0007833 +xref: Wikipedia:Multi-cellular_organism +xref: XAO:0003004 +xref: ZFA:0001094 is_a: UBERON:0010000 ! multicellular anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 + +[Term] +id: UBERON:0000471 +name: compound organ component +def: "Multi-tissue structure that is part of a compound organ." [CARO:0000019, http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010017 +xref: AEO:0000019 +xref: BILA:0000019 +xref: CARO:0000019 +xref: EHDAA2:0003019 +xref: HAO:0000019 +xref: TAO:0001489 +xref: TGMA:0001835 +xref: XAO:0003039 +xref: ZFA:0001489 +is_a: UBERON:0000481 ! multi-tissue structure +relationship: BFO:0000050 UBERON:0003103 ! part of compound organ [Term] id: UBERON:0000474 name: female reproductive system +def: "The organs and associated structures associated with bearing offspring in a female animal." [http://orcid.org/0000-0002-6601-2165, MP:0001119, Wikipedia:Female_genitalia] +xref: BTO:0000083 +xref: CALOHA:TS-1303 +xref: EFO:0000969 +xref: EHDAA2:0000506 +xref: EHDAA:8116 +xref: EMAPA:17959 +xref: EV:0100110 +xref: FMA:45663 +xref: GAID:364 +xref: HAO:0000324 +xref: MA:0000381 +xref: MESH:D005836 +xref: MIAA:0000028 +xref: NCIT:C12402 +xref: SCTID:361386004 +xref: TGMA:0000635 +xref: VHOG:0000726 +xref: Wikipedia:Female_genitalia +xref: WikipediaCategory:Female_reproductive_system +xref: XAO:0000156 is_a: UBERON:0000990 ! reproductive system intersection_of: UBERON:0000990 ! reproductive system intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism relationship: BFO:0000050 UBERON:0003100 ! part of female organism -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000475 name: organism subdivision +def: "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." [CARO:0000032, CARO:DOS, http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010053 +xref: AEO:0000032 +xref: BILA:0000032 +xref: BIRNLEX:7 +xref: CALOHA:TS-2084 +xref: CARO:0000032 +xref: EFO:0000808 +xref: EHDAA2:0003032 +xref: EMAPA:36031 +xref: FMA:7153 +xref: galen:BodyPart +xref: HAO:0000032 +xref: MA:0002433 +xref: MAT:0000293 +xref: MESH:D001829 +xref: MIAA:0000293 +xref: NCIT:C32221 +xref: TAO:0001308 +xref: TGMA:0001840 +xref: VHOG:0001758 +xref: Wikipedia:Body_part +xref: XAO:0003013 +xref: ZFA:0001308 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: BFO:0000051 UBERON:0000075 {gci_filler="NCBITaxon:7742", gci_relation="BFO:0000050"} ! has part subdivision of skeletal system @@ -32790,29 +43702,52 @@ relationship: RO:0002131 UBERON:0001015 {gci_filler="NCBITaxon:6072", gci_relati relationship: RO:0002131 UBERON:0001016 {gci_filler="NCBITaxon:6072", gci_relation="RO:0002162"} ! overlaps nervous system relationship: RO:0002131 UBERON:0001434 {gci_filler="NCBITaxon:33213", gci_relation="RO:0002162"} ! overlaps skeletal system relationship: RO:0002131 UBERON:0002416 {gci_filler="NCBITaxon:6072", gci_relation="RO:0002162"} ! overlaps integumental system -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000476 name: acellular anatomical structure +def: "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010268 +xref: AEO:0000040 +xref: BILA:0000040 +xref: CARO:0000040 +xref: EHDAA2:0003040 +xref: FMA:63863 +xref: HAO:0000040 +xref: TAO:0000382 +xref: TGMA:0001841 +xref: XAO:0003162 +xref: ZFA:0000382 is_a: UBERON:0000061 ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000477 name: anatomical cluster +def: "Anatomical group whose component anatomical structures lie in close proximity to each other." [FBbt:00007277] +xref: VHOG:0001737 is_a: UBERON:0034923 ! disconnected anatomical group -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000478 name: extraembryonic structure +def: "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." [CARO:DOS, http://orcid.org/0000-0001-9114-8737, https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279] +comment: see also conceptus extraembryonic component in EHDAA2. +xref: AAO:0010020 +xref: AEO:0000042 +xref: BILA:0000042 +xref: CALOHA:TS-2119 +xref: CARO:0000042 +xref: EHDAA2:0003042 +xref: EHDAA:46 +xref: FMA:85537 +xref: HAO:0000042 +xref: NCIT:C34055 +xref: SCTID:314908006 +xref: TAO:0000020 +xref: TGMA:0001843 +xref: VHOG:0000292 +xref: XAO:0004005 +xref: ZFA:0000020 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component @@ -32822,26 +43757,77 @@ relationship: RO:0002491 UBERON:0000068 {gci_filler="NCBITaxon:6072", gci_relati [Term] id: UBERON:0000479 name: tissue +def: "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." [CARO:0000043] +xref: AAO:0000607 +xref: AAO:0010054 +xref: AEO:0000043 +xref: BILA:0000043 +xref: BIRNLEX:19 +xref: CALOHA:TS-2090 +xref: CARO:0000043 +xref: EHDAA2:0003043 +xref: EMAPA:35868 +xref: FMA:9637 +xref: galen:Tissue +xref: HAO:0000043 +xref: MA:0003002 +xref: MESH:D014024 +xref: NCIT:C12801 +xref: TAO:0001477 +xref: TGMA:0001844 +xref: VHOG:0001757 +xref: WBbt:0005729 +xref: XAO:0003040 +xref: ZFA:0001477 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: BFO:0000051 GO:0031012 ! has part extracellular matrix -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000481 name: multi-tissue structure +def: "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." [CARO:0000055, http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010048 +xref: AEO:0000055 +xref: BILA:0000055 +xref: CARO:0000055 +xref: EHDAA2:0003055 +xref: HAO:0000055 +xref: TAO:0001488 +xref: TGMA:0001847 +xref: VHOG:0001762 +xref: XAO:0003037 +xref: ZFA:0001488 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 NCBITaxon:6072 {gci_filler="NCBITaxon:6072", gci_relation="RO:0002162"} ! part of Eumetazoa relationship: BFO:0000051 UBERON:0000479 ! has part tissue -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000483 name: epithelium +def: "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." [http://orcid.org/0000-0001-9114-8737, Wikipedia:Epithelium] +comment: Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it? +xref: AAO:0000144 +xref: AAO:0010055 +xref: AEO:0000066 +xref: BILA:0000066 +xref: BTO:0000416 +xref: CALOHA:TS-0288 +xref: CARO:0000066 +xref: EHDAA2:0003066 +xref: EMAPA:32738 +xref: FMA:9639 +xref: GAID:402 +xref: HAO:0000066 +xref: MA:0003060 +xref: MESH:D004848 +xref: NCIT:C12710 +xref: SCTID:31610004 +xref: TAO:0001486 +xref: VHOG:0000387 +xref: Wikipedia:Epithelium +xref: XAO:0003045 +xref: ZFA:0001486 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002473 CL:0000066 ! epithelial cell @@ -32855,23 +43841,79 @@ relationship: RO:0002473 CL:0000066 ! epithelial cell [Term] id: UBERON:0000484 name: simple cuboidal epithelium +def: "Unilaminar epithelium that consists of a single layer of cuboidal cells." [http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_cuboidal_epithelium] +xref: AAO:0010064 +xref: AEO:0000067 +xref: BILA:0000067 +xref: CARO:0000067 +xref: EHDAA2:0003067 +xref: FMA:45566 +xref: HAO:0000067 +xref: NCIT:C33553 +xref: TAO:0001497 +xref: Wikipedia:Simple_cuboidal_epithelium +xref: XAO:0004009 +xref: ZFA:0001497 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0010077 ! cuboidal epithelium [Term] id: UBERON:0000485 name: simple columnar epithelium +def: "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]." [FMA:FMA, http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_columnar_epithelium] +xref: AAO:0010063 +xref: AEO:0000068 +xref: BILA:0000068 +xref: CARO:0000068 +xref: EHDAA2_RETIRED:0003068 +xref: FMA:45567 +xref: HAO:0000068 +xref: NCIT:C33552 +xref: SCTID:32210007 +xref: TAO:0001496 +xref: Wikipedia:Simple_columnar_epithelium +xref: XAO:0004008 +xref: ZFA:0001496 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0012274 ! columnar epithelium [Term] id: UBERON:0000486 name: multilaminar epithelium +def: "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]." [FMA:FMA, http://orcid.org/0000-0001-9114-8737, Wikipedia:Stratified_epithelium] +xref: AAO:0010059 +xref: AEO:0000069 +xref: BILA:0000069 +xref: BTO:0002074 +xref: CARO:0000069 +xref: EHDAA2:0003069 +xref: FMA:45562 +xref: HAO:0000069 +xref: NCIT:C33622 +xref: SCTID:309044005 +xref: TAO:0001494 +xref: Wikipedia:Stratified_epithelium +xref: XAO:0004006 +xref: ZFA:0001494 is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0000487 name: simple squamous epithelium +def: "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]." [FMA:45565, http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_squamous_epithelium] +xref: AAO:0010066 +xref: AEO:0000070 +xref: BILA:0000070 +xref: BTO:0002073 +xref: CARO:0000070 +xref: EHDAA2:0003070 +xref: FMA:45565 +xref: HAO:0000070 +xref: NCIT:C13178 +xref: TAO:0001498 +xref: Wikipedia:Simple_squamous_epithelium +xref: XAO:0004010 +xref: ZFA:0001498 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium @@ -32880,11 +43922,35 @@ intersection_of: BFO:0000051 CL:0000076 ! has part squamous epithelial cell [Term] id: UBERON:0000488 name: atypical epithelium +def: "Epithelium that consists of epithelial cells not arranged in one ore more layers." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010057 +xref: AEO:0000071 +xref: BILA:0000071 +xref: CARO:0000071 +xref: EHDAA2:0003071 +xref: FMA:61741 +xref: HAO:0000071 +xref: TAO:0001493 +xref: XAO:0004004 +xref: ZFA:0001493 is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0000489 name: cavitated compound organ +def: "Compound organ that contains one or more macroscopic anatomical spaces." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010016 +xref: AEO:0000072 +xref: BILA:0000072 +xref: CARO:0000072 +xref: EHDAA2:0003072 +xref: FMA:55671 +xref: HAO:0000072 +xref: TAO:0001490 +xref: TGMA:0001857 +xref: VHOG:0001730 +xref: XAO:0003165 +xref: ZFA:0001490 is_a: UBERON:0003103 ! compound organ intersection_of: UBERON:0003103 ! compound organ intersection_of: BFO:0000051 UBERON:0002553 ! has part anatomical cavity @@ -32893,11 +43959,49 @@ relationship: BFO:0000051 UBERON:0002553 ! has part anatomical cavity [Term] id: UBERON:0000490 name: unilaminar epithelium +def: "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]." [FMA:45561, http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010062 +xref: AEO:0000073 +xref: BILA:0000073 +xref: BTO:0002073 +xref: CARO:0000073 +xref: EHDAA2:0003073 +xref: FMA:45561 +xref: HAO:0000073 +xref: NCIT:C33554 +xref: SCTID:309043004 +xref: TAO:0001495 +xref: XAO:0004007 +xref: ZFA:0001495 is_a: UBERON:0000483 ! epithelium +[Term] +id: UBERON:0000912 +name: mucus +def: "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water." [Wikipedia:Mucus] +xref: CALOHA:TS-2144 +xref: ENVO:02000040 +xref: FMA:66938 +xref: GAID:1164 +xref: galen:Mucus +xref: MESH:D009093 +xref: NCIT:C13259 +xref: Wikipedia:Mucus +is_a: UBERON:0000456 ! secretion of exocrine gland +is_a: UBERON:0006314 ! bodily fluid +relationship: BFO:0000051 CHEBI:37395 ! has part +relationship: RO:0000086 PATO:0000998 +relationship: RO:0003001 UBERON:0000344 ! produced by mucosa + [Term] id: UBERON:0000915 name: thoracic segment of trunk +def: "Subdivision of trunk that lies between the head and the abdomen." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:35862 +xref: FMA:259209 +xref: MA:0000022 +xref: SCTID:302551006 +xref: Wikipedia:Thorax is_a: UBERON:0009569 ! subdivision of trunk is_a: UBERON:0011676 ! subdivision of organism along main body axis intersection_of: UBERON:0011676 ! subdivision of organism along main body axis @@ -32907,6 +44011,21 @@ relationship: RO:0002551 UBERON:0014477 ! thoracic skeleton [Term] id: UBERON:0000916 name: abdomen +def: "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000020 +xref: CALOHA:TS-0001 +xref: EFO:0000968 +xref: EMAPA:35102 +xref: EV:0100011 +xref: FMA:9577 +xref: GAID:16 +xref: galen:Abdomen +xref: MA:0000029 +xref: MAT:0000298 +xref: MESH:D000005 +xref: MIAA:0000298 +xref: SCTID:302553009 +xref: Wikipedia:Abdomen is_a: UBERON:0009569 ! subdivision of trunk relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -32914,6 +44033,31 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0000922 name: embryo +def: "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [BTO:0000379, FB:FBrf0039741, FB:FBrf0041814, GO:0009790, Wikipedia:Embryo] +xref: AAO:0011035 +xref: AEO:0000169 +xref: BILA:0000056 +xref: BSA:0000039 +xref: BTO:0000379 +xref: CALOHA:TS-0229 +xref: EFO:0001367 +xref: EHDAA2:0000002 +xref: EHDAA2_RETIRED:0003236 +xref: EHDAA:38 +xref: EMAPA:16039 +xref: FMA:69068 +xref: GAID:963 +xref: http://neurolex.org/wiki/Category\:Embryonic_organism +xref: MAT:0000226 +xref: MESH:D004622 +xref: MIAA:0000019 +xref: NCIT:C28147 +xref: OGEM:000001 +xref: SCTID:57991002 +xref: VHOG:0001766 +xref: Wikipedia:Embryo +xref: XAO:0000113 +xref: ZFA:0000103 is_a: UBERON:0000468 ! multicellular organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002489 UBERON:0000068 ! embryo stage @@ -32924,12 +44068,50 @@ relationship: RO:0002493 UBERON:0000068 ! embryo stage [Term] id: UBERON:0000923 name: germ layer +def: "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm." [https://github.com/obophenotype/uberon/issues/203, Wikipedia:Germ_layer] +comment: Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest] +xref: AAO:0000480 +xref: BILA:0000035 +xref: BTO:0000556 +xref: EMAPA:36033 +xref: FMA:69069 +xref: GAID:1303 +xref: MESH:D005855 +xref: NCIT:C12950 +xref: NCIT:C54105 +xref: TAO:0001122 +xref: VHOG:0001223 +xref: Wikipedia:Germ_layer +xref: XAO:0003011 +xref: ZFA:0001122 is_a: UBERON:0010316 ! germ layer / neural crest relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0000924 name: ectoderm +def: "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." [Wikipedia:Ectoderm] +xref: AAO:0000137 +xref: BILA:0000036 +xref: BTO:0000315 +xref: CALOHA:TS-0216 +xref: EFO:0000414 +xref: EHDAA2:0000428 +xref: EMAPA:16069 +xref: EV:0100003 +xref: FMA:69070 +xref: GAID:1304 +xref: MAT:0000155 +xref: MAT:0000173 +xref: MESH:D004475 +xref: MIAA:0000173 +xref: NCIT:C12703 +xref: SCTID:362851007 +xref: TAO:0000016 +xref: VHOG:0000153 +xref: Wikipedia:Ectoderm +xref: XAO:0000001 +xref: ZFA:0000016 is_a: UBERON:0000923 ! germ layer relationship: BFO:0000051 CL:0000221 ! has part ectodermal cell relationship: RO:0002495 UBERON:0006601 ! presumptive ectoderm @@ -32937,6 +44119,27 @@ relationship: RO:0002495 UBERON:0006601 ! presumptive ectoderm [Term] id: UBERON:0000925 name: endoderm +def: "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut." [Wikipedia:Endoderm] +xref: AAO:0000139 +xref: BILA:0000038 +xref: BTO:0000800 +xref: CALOHA:TS-0273 +xref: EFO:0002545 +xref: EHDAA2:0000436 +xref: EMAPA:16062 +xref: EV:0100005 +xref: FMA:69071 +xref: GAID:1305 +xref: MAT:0000175 +xref: MESH:D004707 +xref: MIAA:0000175 +xref: NCIT:C12706 +xref: SCTID:362855003 +xref: TAO:0000017 +xref: VHOG:0000154 +xref: Wikipedia:Endoderm +xref: XAO:0000090 +xref: ZFA:0000017 is_a: UBERON:0000923 ! germ layer relationship: BFO:0000051 CL:0000223 ! has part endodermal cell relationship: RO:0002495 UBERON:0006595 ! presumptive endoderm @@ -32944,6 +44147,30 @@ relationship: RO:0002495 UBERON:0006595 ! presumptive endoderm [Term] id: UBERON:0000926 name: mesoderm +def: "The middle germ layer of the embryo, between the endoderm and ectoderm." [Wikipedia:Mesoderm] +xref: AAO:0000304 +xref: BILA:0000037 +xref: BTO:0000839 +xref: CALOHA:TS-0623 +xref: EFO:0001981 +xref: EHDAA2:0001128 +xref: EHDAA:124 +xref: EHDAA:160 +xref: EHDAA:183 +xref: EMAPA:16083 +xref: EV:0100006 +xref: FMA:69072 +xref: GAID:522 +xref: MAT:0000174 +xref: MESH:D008648 +xref: MIAA:0000174 +xref: NCIT:C12750 +xref: SCTID:362854004 +xref: TAO:0000041 +xref: VHOG:0000152 +xref: Wikipedia:Mesoderm +xref: XAO:0000050 +xref: ZFA:0000041 is_a: UBERON:0000923 ! germ layer relationship: BFO:0000051 CL:0000222 ! has part mesodermal cell relationship: RO:0002495 UBERON:0006603 ! presumptive mesoderm @@ -32951,35 +44178,131 @@ relationship: RO:0002495 UBERON:0006603 ! presumptive mesoderm [Term] id: UBERON:0000930 name: stomodeum +def: "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/326, Wikipedia:Stomodeum] +xref: BTO:0004224 +xref: EHDAA2:0001929 +xref: EMAPA:16263 +xref: FMA:295846 +xref: NCIT:C34306 +xref: TAO:0001290 +xref: TGMA:0000135 +xref: Wikipedia:Stomodeum +xref: XAO:0000269 +xref: ZFA:0001290 is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm relationship: BFO:0000050 UBERON:0035804 ! part of future mouth relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa +[Term] +id: UBERON:0000931 +name: proctodeum +def: "Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract." [https://github.com/obophenotype/uberon/issues/685, https://sourceforge.net/p/fbbtdv/tickets/52, ZFA:0000066] +xref: AAO:0011087 +xref: EHDAA2:0000121 +xref: EMAPA:25038 +xref: NCIT:C34278 +xref: TAO:0000066 +xref: VHOG:0000139 +xref: Wikipedia:Proctodeum +xref: XAO:0001019 +xref: ZFA:0000066 +is_a: UBERON:0016566 ! pit +relationship: BFO:0000050 UBERON:0007026 ! part of presumptive gut +relationship: RO:0001025 UBERON:0012469 ! external anal region +relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa +relationship: RO:0002202 UBERON:0000924 ! ectoderm +relationship: RO:0002387 UBERON:0001353 ! anal region + [Term] id: UBERON:0000945 name: stomach +def: "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584, Wikipedia:Stomach] +xref: AAO:0000579 +xref: ANISEED:1235297 +xref: BTO:0001307 +xref: CALOHA:TS-0980 +xref: EFO:0000837 +xref: EHDAA2:0001915 +xref: EHDAA:2993 +xref: EMAPA:17021 +xref: EV:0100070 +xref: FMA:7148 +xref: GAID:293 +xref: galen:Stomach +xref: MA:0000353 +xref: MAT:0000051 +xref: MESH:D013270 +xref: MIAA:0000051 +xref: NCIT:C12391 +xref: SCTID:181246003 +xref: TAO:0002121 +xref: VHOG:0000408 +xref: Wikipedia:Stomach +xref: XAO:0000128 is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0010039 ! food storage organ relationship: BFO:0000050 UBERON:0001041 ! part of foregut relationship: RO:0002160 NCBITaxon:7776 ! Gnathostomata relationship: RO:0002215 GO:0001696 ! capable of gastric acid secretion relationship: RO:0002433 UBERON:0001007 ! digestive system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000947 name: aorta +def: "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MESH:A07.231.114.056, MP:0000272, Wikipedia:Aorta] +xref: AAO:0010213 +xref: BTO:0000135 +xref: CALOHA:TS-0046 +xref: EFO:0000265 +xref: EMAPA:18601 +xref: EV:0100027 +xref: FMA:3734 +xref: GAID:469 +xref: galen:Aorta +xref: MA:0000062 +xref: MAT:0000035 +xref: MESH:D001011 +xref: MIAA:0000035 +xref: NCIT:C12669 +xref: SCTID:181298001 +xref: VHOG:0001523 +xref: Wikipedia:Aorta +xref: XAO:0003010 is_a: UBERON:0003509 ! arterial blood vessel is_a: UBERON:0003519 ! thoracic cavity blood vessel is_a: UBERON:0013768 ! great vessel of heart relationship: BFO:0000050 UBERON:0010191 ! part of aortic system relationship: RO:0002170 UBERON:0002084 ! heart left ventricle -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000948 name: heart +def: "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Heart] +comment: Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 +xref: AAO:0010210 +xref: BILA:0000020 +xref: BTO:0000562 +xref: CALOHA:TS-0445 +xref: EFO:0000815 +xref: EHDAA2:0000738 +xref: EHDAA:420 +xref: EMAPA:16105 +xref: EV:0100018 +xref: FMA:7088 +xref: GAID:174 +xref: galen:Heart +xref: MA:0000072 +xref: MAT:0000036 +xref: MESH:D006321 +xref: MIAA:0000036 +xref: NCIT:C12727 +xref: SCTID:302509004 +xref: TAO:0000114 +xref: VHOG:0000276 +xref: Wikipedia:Heart +xref: XAO:0000064 +xref: ZFA:0000114 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0007100 ! primary circulatory organ @@ -32991,11 +44314,28 @@ relationship: BFO:0000051 UBERON:0004151 ! has part cardiac chamber relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002202 UBERON:0004141 ! heart tube relationship: RO:0002433 UBERON:0004535 ! cardiovascular system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000949 name: endocrine system +def: "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity." [NLM:endocrine+system, Wikipedia:Endocrine_system] +xref: AAO:0010279 +xref: CALOHA:TS-1301 +xref: EFO:0002969 +xref: EHDAA2:0002224 +xref: EMAPA:35306 +xref: EV:0100128 +xref: FMA:9668 +xref: GAID:439 +xref: MA:0000012 +xref: MESH:D004703 +xref: NCIT:C12705 +xref: SCTID:278876000 +xref: TAO:0001158 +xref: VHOG:0000098 +xref: Wikipedia:Endocrine_system +xref: XAO:0000158 +xref: ZFA:0001158 is_a: UBERON:0015204 ! glandular system disjoint_from: UBERON:0000990 ! reproductive system disjoint_from: UBERON:0001004 ! respiratory system @@ -33004,10 +44344,12 @@ disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa @@ -33017,20 +44359,56 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0000955 name: brain +def: "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Brain] +xref: AAO:0010478 +xref: ABA:Brain +xref: BAMS:Br +xref: BAMS:Brain +xref: BILA:0000135 +xref: BIRNLEX:796 +xref: BTO:0000142 +xref: CALOHA:TS-0095 +xref: DHBA:10155 +xref: EFO:0000302 +xref: EHDAA2:0000183 +xref: EHDAA:2641 +xref: EHDAA:6485 +xref: EMAPA:16894 +xref: EV:0100164 +xref: FMA:50801 +xref: GAID:571 +xref: galen:Brain +xref: HBA:4005 +xref: MA:0000168 +xref: MAT:0000098 +xref: MBA:8 +xref: MBA:997 +xref: MESH:D001921 +xref: MIAA:0000098 +xref: NCIT:C12439 +xref: PBA:3999 +xref: SCTID:258335003 +xref: TAO:0000008 +xref: VHOG:0000157 +xref: Wikipedia:Brain +xref: XAO:0000010 +xref: ZFA:0000008 is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BSPO:0000123 UBERON:0000468 ! multicellular organism relationship: RO:0002202 UBERON:0001049 {gci_filler="NCBITaxon:7711", gci_relation="BFO:0000050"} ! neural tube +relationship: RO:0002215 GO:0050890 {gci_filler="NCBITaxon:9606", gci_relation="BFO:0000050"} ! capable of cognition relationship: RO:0002433 UBERON:0001016 ! nervous system relationship: RO:0002473 CL:0002319 ! neural cell relationship: RO:0002492 UBERON:0000066 ! fully formed stage relationship: RO:0002495 UBERON:0006238 ! future brain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000957 name: lamina +def: "Any thin layer or plate." [Wikipedia:Lamina_of_the_vertebral_arch] +xref: Wikipedia:Lamina_of_the_vertebral_arch is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0000086 PATO:0002124 @@ -33039,15 +44417,25 @@ relationship: RO:0000086 PATO:0002124 [Term] id: UBERON:0000962 name: nerve of cervical vertebra +def: "The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]." [Wikipedia:Cervical_nerves] +comment: Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP] +xref: BAMS:cern +xref: FMA:5859 +xref: NCIT:C32299 +xref: neuronames:2351 +xref: NLXANAT:20090207 +xref: SCTID:360497008 +xref: Wikipedia:Cervical_nerves is_a: UBERON:0001780 ! spinal nerve intersection_of: UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0002726 ! cervical spinal cord relationship: extends_fibers_into UBERON:0002726 ! cervical spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000963 name: head sensillum +xref: MAT:0000204 +xref: MIAA:0000204 is_a: UBERON:0002536 ! arthropod sensillum intersection_of: UBERON:0002536 ! arthropod sensillum intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -33056,6 +44444,26 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0000964 name: cornea +def: "The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure." [ISBN:0-683-40008-8, MESH:A09.371.060.217, MP:0001312] +xref: AAO:0010344 +xref: BTO:0000286 +xref: CALOHA:TS-0171 +xref: EFO:0000377 +xref: EHDAA2:0000316 +xref: EHDAA:10199 +xref: EMAPA:17161 +xref: EV:0100341 +xref: FMA:58238 +xref: GAID:892 +xref: MA:0000266 +xref: MESH:D003315 +xref: NCIT:C12342 +xref: SCTID:181162001 +xref: TAO:0000640 +xref: VHOG:0000164 +xref: Wikipedia:Cornea +xref: XAO:0000180 +xref: ZFA:0000640 is_a: UBERON:0010000 ! multicellular anatomical structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: BFO:0000050 UBERON:0001801 ! part of anterior segment of eyeball @@ -33069,22 +44477,69 @@ relationship: RO:0002202 UBERON:0004348 ! optic eminence relationship: RO:0002202 UBERON:0005427 ! corneal primordium relationship: RO:0002256 UBERON:0005426 ! lens vesicle relationship: RO:0002433 UBERON:0001801 ! anterior segment of eyeball -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000965 name: lens of camera-type eye +def: "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lens_(anatomy)] +comment: The lens is avascular and nourished by diffusion from the aqueous and vitreous humors. +xref: AAO:0010348 +xref: BTO:0000723 +xref: CALOHA:TS-0545 +xref: EHDAA:9057 +xref: EMAPA:17838 +xref: EV:0100343 +xref: FMA:58241 +xref: MA:0000275 +xref: MAT:0000141 +xref: MESH:D007908 +xref: MIAA:0000141 +xref: NCIT:C12743 +xref: RETIRED_EHDAA2:0000975 +xref: SCTID:181169005 +xref: TAO:0000035 +xref: VHOG:0000169 +xref: Wikipedia:Lens_(anatomy) +xref: XAO:0000008 +xref: ZFA:0000035 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005389 ! transparent eye structure relationship: BFO:0000050 UBERON:0001801 ! part of anterior segment of eyeball relationship: RO:0002202 UBERON:0005426 ! lens vesicle relationship: RO:0002256 UBERON:0003902 ! retinal neural layer relationship: RO:0002433 UBERON:0001801 ! anterior segment of eyeball -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000966 name: retina +def: "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [Wikipedia:Retina, ZFIN:curator] +comment: Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods +xref: AAO:0010352 +xref: BAMS:R +xref: BIRNLEX:1153 +xref: BTO:0001175 +xref: CALOHA:TS-0865 +xref: EFO:0000832 +xref: EHDAA2:0001627 +xref: EHDAA:4757 +xref: EMAPA:17168 +xref: EV:0100348 +xref: FMA:58301 +xref: GAID:755 +xref: MA:0000276 +xref: MAT:0000142 +xref: MBA:304325711 +xref: MESH:D012160 +xref: MIAA:0000142 +xref: NCIT:C12343 +xref: neuronames:1862 +xref: NIFSTD_RETIRED:birnlex_1156 +xref: SCTID:181171005 +xref: TAO:0000152 +xref: VHOG:0000229 +xref: Wikipedia:Retina +xref: XAO:0000009 +xref: ZFA:0000152 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005388 ! photoreceptor array relationship: BFO:0000050 UBERON:0001802 ! part of posterior segment of eyeball @@ -33093,21 +44548,36 @@ relationship: BFO:0000051 CL:0000573 ! has part retinal cone cell relationship: BFO:0000051 CL:0000604 ! has part retinal rod cell relationship: BFO:0000051 CL:0000740 ! has part retinal ganglion cell relationship: RO:0002202 UBERON:0003072 ! optic cup -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000970 name: eye +def: "An organ that detects light." [https://orcid.org/0000-0002-6601-2165] +xref: BILA:0000017 +xref: BTO:0000439 +xref: CALOHA:TS-0309 +xref: EFO:0000827 +xref: EV:0100336 +xref: GAID:69 +xref: MAT:0000140 +xref: MESH:D005123 +xref: MIAA:0000140 +xref: Wikipedia:Eye is_a: UBERON:0000020 ! sense organ relationship: BFO:0000050 UBERON:0002104 ! part of visual system relationship: BFO:0000051 CL:0000149 ! has part visual pigment cell relationship: BFO:0000051 CL:0000210 ! has part photoreceptor cell relationship: RO:0002215 GO:0009584 ! capable of detection of visible light -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000971 name: ommatidium +def: "The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells." [PMID:21062451] +xref: BTO:0001922 +xref: HAO:0000666 +xref: MAT:0000143 +xref: MIAA:0000143 +xref: Wikipedia:Ommatidium is_a: UBERON:0000970 ! eye is_a: UBERON:0002536 ! arthropod sensillum relationship: BFO:0000050 UBERON:0000018 ! part of compound eye @@ -33115,6 +44585,23 @@ relationship: BFO:0000050 UBERON:0000018 ! part of compound eye [Term] id: UBERON:0000974 name: neck +def: "An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column." [http://orcid.org/0000-0002-6601-2165] +xref: AEO:0000108 +xref: BTO:0000420 +xref: CALOHA:TS-2045 +xref: EFO:0000967 +xref: EHDAA2:0003108 +xref: EMAPA:35587 +xref: FMA:7155 +xref: GAID:86 +xref: galen:Neck +xref: MA:0000024 +xref: MAT:0000297 +xref: MESH:D009333 +xref: MIAA:0000297 +xref: NCIT:C13063 +xref: SCTID:302550007 +xref: Wikipedia:Neck is_a: UBERON:0000475 ! organism subdivision relationship: anteriorly_connected_to UBERON:0000033 ! head relationship: BFO:0000050 UBERON:0000153 ! part of anterior region of body @@ -33123,6 +44610,19 @@ relationship: posteriorly_connected_to UBERON:0002100 ! trunk [Term] id: UBERON:0000977 name: pleura +def: "The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion)." [https://github.com/obophenotype/uberon/issues/1231, ISBN:0-683-40008-8, MP:0010820, UBERON:cjm, Wikipedia:Pulmonary_pleurae] +xref: BTO:0001791 +xref: CALOHA:TS-2081 +xref: EFO:0001980 +xref: EV:0100044 +xref: FMA:9583 +xref: GAID:360 +xref: MA:0000433 +xref: MESH:D010994 +xref: NCIT:C12469 +xref: SCTID:181609007 +xref: VHOG:0000394 +xref: Wikipedia:Pleura is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: UBERON:0000042 ! serous membrane @@ -33140,6 +44640,28 @@ relationship: RO:0002433 UBERON:0001004 ! respiratory system [Term] id: UBERON:0000982 name: skeletal joint +def: "Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000101, Wikipedia:Joint] +xref: AEO:0000182 +xref: BTO:0001686 +xref: CALOHA:TS-2023 +xref: EFO:0000948 +xref: EMAPA:35456 +xref: FMA:7490 +xref: GAID:102 +xref: galen:Joint +xref: MA:0000319 +xref: MAT:0000188 +xref: MESH:D007596 +xref: MIAA:0000188 +xref: NCIT:C13044 +xref: RETIRED_EHDAA2:0003182 +xref: SCTID:302536002 +xref: TAO:0000367 +xref: VHOG:0001276 +xref: VSAO:0000101 +xref: Wikipedia:Joint +xref: XAO:0000171 +xref: ZFA:0001596 is_a: UBERON:0004905 ! articulation union_of: UBERON:0002217 ! synovial joint union_of: UBERON:0011134 ! nonsynovial joint @@ -33150,17 +44672,64 @@ relationship: RO:0002433 UBERON:0001434 ! skeletal system [Term] id: UBERON:0000988 name: pons +def: "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum." [VHOG:0001176] +xref: BAMS:PONS +xref: BAMS:Pons +xref: BIRNLEX:733 +xref: BM:Pons +xref: BTO:0001101 +xref: CALOHA:TS-0813 +xref: DHBA:10661 +xref: EFO:0001394 +xref: EHDAA2:0004394 +xref: EMAPA:17563 +xref: EV:0100253 +xref: FMA:67943 +xref: GAID:578 +xref: HBA:9131 +xref: MA:0000204 +xref: MAT:0000115 +xref: MBA:771 +xref: MESH:D011149 +xref: MIAA:0000115 +xref: NCIT:C12511 +xref: SCTID:279103004 +xref: VHOG:0001176 +xref: Wikipedia:Pons is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001895 ! part of metencephalon relationship: BFO:0000050 UBERON:0002298 ! part of brainstem relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002433 UBERON:0001895 ! metencephalon relationship: RO:0002433 UBERON:0002298 ! brainstem -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000990 name: reproductive system +def: "Anatomical system that has as its parts the organs concerned with reproduction." [Wikipedia:Reproductive_system] +xref: AAO:0010258 +xref: BILA:0000103 +xref: BTO:0000081 +xref: CALOHA:TS-1318 +xref: EFO:0000809 +xref: EHDAA2:0001603 +xref: EHDAA:5923 +xref: EMAPA:17381 +xref: EV:0100100 +xref: FMA:7160 +xref: GAID:363 +xref: HAO:0000374 +xref: HAO:0000895 +xref: MA:0000326 +xref: MIAA:0000305 +xref: NCIT:C12841 +xref: SCTID:278875001 +xref: TAO:0000632 +xref: VHOG:0000182 +xref: WBbt:0005747 +xref: Wikipedia:Reproductive_system +xref: XAO:0000142 +xref: ZFA:0000632 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002216 GO:0022414 ! capable of part of reproductive process @@ -33170,20 +44739,40 @@ disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 UBERON:0000991 ! has part gonad relationship: RO:0002216 GO:0022414 ! capable of part of reproductive process relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000991 name: gonad +def: "Reproductive organ that produces and releases eggs (ovary) or sperm (testis)." [ISBN:0140512888, Wikipedia:Gonad, ZFA:0000413, ZFIN:curator] +xref: AAO:0000213 +xref: BILA:0000123 +xref: BSA:0000079 +xref: BTO:0000534 +xref: EMAPA:17383 +xref: FMA:18250 +xref: GAID:368 +xref: HAO:0000379 +xref: MA:0002420 +xref: MESH:D006066 +xref: NCIT:C12725 +xref: SCTID:304623008 +xref: TAO:0000413 +xref: VHOG:0000397 +xref: WBbt:0005175 +xref: Wikipedia:Gonad +xref: XAO:0003146 +xref: ZFA:0000413 is_a: UBERON:0003133 ! reproductive organ intersection_of: UBERON:0003133 ! reproductive organ intersection_of: BFO:0000051 CL:0000586 ! has part germ cell @@ -33194,6 +44783,29 @@ relationship: RO:0002202 UBERON:0005564 ! gonad primordium [Term] id: UBERON:0000992 name: ovary +def: "The gonad of a female organism which contains germ cells." [ISBN:0-683-40008-8, MP:0001126, Wikipedia:Ovary] +xref: AAO:0000371 +xref: BILA:0000125 +xref: BSA:0000080 +xref: BTO:0000975 +xref: CALOHA:TS-0730 +xref: EFO:0000973 +xref: EHDAA2:0001360 +xref: EHDAA:8124 +xref: EMAPA:17962 +xref: EV:0100111 +xref: FMA:7209 +xref: GAID:367 +xref: MA:0000384 +xref: MESH:D010053 +xref: MIAA:0000125 +xref: NCIT:C12404 +xref: SCTID:181464007 +xref: TAO:0000403 +xref: VHOG:0000251 +xref: Wikipedia:Ovary +xref: XAO:0000258 +xref: ZFA:0000403 is_a: UBERON:0000991 ! gonad is_a: UBERON:0003134 ! female reproductive organ intersection_of: UBERON:0000991 ! gonad @@ -33201,11 +44813,30 @@ intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system disjoint_from: UBERON:0009117 ! indifferent gonad relationship: RO:0002160 NCBITaxon:33208 ! Metazoa relationship: RO:0002202 UBERON:0009117 ! indifferent gonad -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001003 name: skin epidermis +def: "The outer epithelial layer of the skin that is superficial to the dermis." [http://orcid.org/0000-0002-6601-2165, ISBN:0073040584] +xref: AAO:0000143 +xref: BTO:0000404 +xref: CALOHA:TS-0283 +xref: EFO:0000954 +xref: EMAPA:17528 +xref: EV:0100153 +xref: FMA:70596 +xref: GAID:932 +xref: MA:0000153 +xref: MAT:0000154 +xref: MESH:D004817 +xref: MIAA:0000154 +xref: NCIT:C12708 +xref: SCTID:361694003 +xref: TAO:0000105 +xref: VHOG:0000077 +xref: Wikipedia:Epidermis_(skin) +xref: XAO:0000028 +xref: ZFA:0000105 is_a: UBERON:0007376 ! outer epithelium is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:0007376 ! outer epithelium @@ -33213,11 +44844,32 @@ intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: RO:0002220 UBERON:0002067 ! adjacent to dermis relationship: RO:0002285 UBERON:0003055 ! periderm -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001004 name: respiratory system +def: "Functional system which consists of structures involved in respiration." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Respiratory_system] +xref: AAO:0000541 +xref: BTO:0000203 +xref: CALOHA:TS-1319 +xref: EFO:0000804 +xref: EHDAA2:0001604 +xref: EHDAA:2203 +xref: EMAPA:16727 +xref: EV:0100036 +xref: FMA:7158 +xref: GAID:78 +xref: MA:0000327 +xref: MAT:0000030 +xref: MESH:D012137 +xref: MIAA:0000030 +xref: NCIT:C12779 +xref: SCTID:278197002 +xref: TAO:0000272 +xref: VHOG:0000202 +xref: Wikipedia:Respiratory_system +xref: XAO:0000117 +xref: ZFA:0000272 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system @@ -33226,21 +44878,25 @@ disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002160 NCBITaxon:33213 ! Bilateria relationship: RO:0002215 GO:0003016 ! capable of respiratory system process relationship: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001005 name: respiratory airway +def: "An airway through which respiratory air passes in organisms." [Wikipedia:Trachea] +xref: SCTID:361380005 +xref: Wikipedia:Trachea is_a: UBERON:0003103 ! compound organ is_a: UBERON:0004111 ! anatomical conduit relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -33249,6 +44905,27 @@ relationship: channel_for UBERON:0034874 ! air in respiratory system [Term] id: UBERON:0001007 name: digestive system +def: "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." [FB:gg, NLM:alimentary+system, Wikipedia:Digestive_system] +xref: AAO:0000129 +xref: BILA:0000082 +xref: BTO:0000058 +xref: CALOHA:TS-1293 +xref: EFO:0000793 +xref: FMA:7152 +xref: GAID:278 +xref: galen:DigestiveSystem +xref: MA:0002431 +xref: MAT:0000018 +xref: MESH:D004064 +xref: MIAA:0000018 +xref: ncithesaurus:Digestive_System +xref: SCTID:278859004 +xref: TADS:0000170 +xref: TAO:0000339 +xref: WBbt:0005748 +xref: Wikipedia:Digestive_system +xref: XAO:0000125 +xref: ZFA:0000339 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002215 GO:0022600 ! capable of digestive system process @@ -33256,47 +44933,126 @@ disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002215 GO:0022600 ! capable of digestive system process relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001008 +name: renal system +def: "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products." [DOI:10.1371/journal.pone.0099864, GO:0072001] +comment: EDITOR_NOTE In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here +xref: AAO:0010257 +xref: BILA:0000015 +xref: BTO:0001244 +xref: BTO:0003092 +xref: CALOHA:TS-1323 +xref: EFO:0000803 +xref: EHDAA2:0001601 +xref: EHDAA:5901 +xref: EMAPA:17366 +xref: EV:0100095 +xref: FMA:7159 +xref: GAID:391 +xref: galen:UrinaryTract +xref: MA:0000325 +xref: MAT:0000027 +xref: MESH:D014551 +xref: MIAA:0000027 +xref: NCIT:C12413 +xref: SCTID:362204003 +xref: TADS:0000162 +xref: TAO:0000163 +xref: VHOG:0000723 +xref: WBbt:0005736 +xref: Wikipedia:Excretory_system +xref: XAO:0000143 +xref: ZFA:0000163 +is_a: UBERON:8450002 ! excretory system +intersection_of: UBERON:8450002 ! excretory system +intersection_of: RO:0002215 GO:0097254 ! capable of renal tubular secretion +relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa +relationship: RO:0002215 GO:0097254 ! capable of renal tubular secretion +relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0001009 name: circulatory system +def: "Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]." [Wikipedia:Circulatory_system] +xref: AAO:0000959 +xref: CALOHA:TS-2103 +xref: VHOG:0001248 +xref: Wikipedia:Circulatory_system is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002160 NCBITaxon:33213 ! Bilateria relationship: RO:0002215 GO:0003013 ! capable of circulatory system process relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001013 name: adipose tissue +def: "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue." [http://orcid.org/0000-0002-6601-2165, MESH:A10.165.114, MGI:cwg, MP:0000003, Wikipedia:Adipose_tissue] +xref: AAO:0000001 +xref: AEO:000020 +xref: BTO:0001487 +xref: CALOHA:TS-0013 +xref: EFO:0000790 +xref: EHDAA2:0003120 +xref: EMAPA:35112 +xref: EV:0100381 +xref: FMA:20110 +xref: GAID:920 +xref: galen:FattyTissue +xref: MA:0000009 +xref: MAT:0000015 +xref: MESH:D000273 +xref: MIAA:0000015 +xref: NCIT:C12472 +xref: SCTID:55603005 +xref: TAO:0002134 +xref: VHOG:0001284 +xref: Wikipedia:Adipose_tissue +xref: XAO:0003049 +xref: ZFA:0005345 is_a: UBERON:0011822 ! dense irregular connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002473 CL:0000136 ! adipocyte disjoint_from: UBERON:0003714 ! neural tissue relationship: RO:0002473 CL:0000136 ! adipocyte -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001015 name: musculature +def: "A subdivision of the muscular system corresponding to a subdisivision of an organism." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Muscular_system] +xref: BTO:0000887 +xref: EFO:0001949 +xref: EMAPA:35577 +xref: FMA:32558 +xref: MA:0000165 +xref: NCIT:C13056 +xref: TAO:0000548 +xref: VSAO:0005038 +xref: WBbt:0005737 +xref: Wikipedia:Muscular_system +xref: ZFA:0000548 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0000383 ! part of musculature of body relationship: RO:0002473 UBERON:0001630 ! muscle organ @@ -33304,13 +45060,41 @@ relationship: RO:0002473 UBERON:0001630 ! muscle organ [Term] id: UBERON:0001016 name: nervous system +def: "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." [BIRNLEX:844, ISBN:0-14-051288-8, ISBN:3110148986, NLM:nervous+system, WB:rynl, Wikipedia:Nervous_system, ZFIN:curator] +xref: AAO:0000324 +xref: BILA:0000079 +xref: BIRNLEX:844 +xref: BTO:0001484 +xref: CALOHA:TS-1313 +xref: EFO:0000802 +xref: EHDAA2:0001246 +xref: EHDAA:826 +xref: EMAPA:16469 +xref: EV:0100162 +xref: FMA:7157 +xref: GAID:466 +xref: MA:0000016 +xref: MAT:0000026 +xref: MESH:D009420 +xref: MIAA:0000026 +xref: NCIT:C12755 +xref: neuronames:3236 +xref: SCTID:278196006 +xref: TAO:0000396 +xref: VHOG:0000402 +xref: WBbt:0005735 +xref: Wikipedia:Nervous_system +xref: XAO:0000177 +xref: ZFA:0000396 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 CL:0000540 ! has part neuron @@ -33319,35 +45103,115 @@ relationship: RO:0002215 GO:0050877 ! capable of nervous system process relationship: RO:0002473 CL:0002319 ! neural cell relationship: RO:0002492 UBERON:0000066 ! fully formed stage relationship: RO:0002495 UBERON:0016880 ! future nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001017 name: central nervous system +def: "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord." [GO:0021551, http://www.frontiersinzoology.com/content/7/1/29, https://sourceforge.net/p/geneontology/ontology-requests/11422/] +xref: AAO:0000090 +xref: BAMS:CNS +xref: BILA:0000080 +xref: BIRNLEX:1099 +xref: BTO:0000227 +xref: CALOHA:TS-0150 +xref: EFO:0000908 +xref: EHDAA2:0000225 +xref: EHDAA:828 +xref: EMAPA:16470 +xref: EMAPA:16754 +xref: EV:0100163 +xref: FMA:55675 +xref: GAID:570 +xref: MA:0000167 +xref: MAT:0000457 +xref: MESH:D002490 +xref: NCIT:C12438 +xref: neuronames:854 +xref: SCTID:278199004 +xref: TAO:0000012 +xref: VHOG:0000293 +xref: Wikipedia:Central_nervous_system +xref: XAO:0000215 +xref: ZFA:0000012 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002160 NCBITaxon:33213 ! Bilateria relationship: RO:0002495 UBERON:0016879 ! future central nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001021 name: nerve +def: "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures." [FBbt:00005105, http://orcid.org/0000-0002-6601-2165] +xref: AAO:0011070 +xref: AEO:0000137 +xref: BAMS:n +xref: BIRNLEX:1615 +xref: BSA:0000098 +xref: BTO:0000925 +xref: BTO:0001027 +xref: CALOHA:TS-0772 +xref: EHDAA2:0003137 +xref: EHDAA:2851 +xref: EHDAA:3776 +xref: EHDAA:4657 +xref: EMAPA:32808 +xref: EMAPA:32815 +xref: EV:0100371 +xref: FMA:65132 +xref: FMA:65239 +xref: GAID:747 +xref: GAID:758 +xref: galen:Nerve +xref: MA:0000217 +xref: MA:0000228 +xref: MESH:D010525 +xref: NCIT:C12466 +xref: NCIT:C12768 +xref: NLX:147826 +xref: SCTID:244457007 +xref: SCTID:256864008 +xref: TAO:0007009 +xref: VHOG:0000901 +xref: Wikipedia:Nervous_system +xref: XAO:0000204 +xref: XAO:0003047 +xref: ZFA:0007009 is_a: UBERON:0000122 ! neuron projection bundle relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system relationship: RO:0000086 PATO:0002045 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001027 name: sensory nerve +def: "A nerve that transmits from sensory receptors on the surface of the body to the central nervous system." [UBERON:cjm, Wikipedia:Sensory_nerve] +xref: AEO:0000201 +xref: EHDAA2:0003200 +xref: FMA:5868 +xref: Wikipedia:Sensory_nerve is_a: UBERON:0001021 ! nerve relationship: BFO:0000051 CL:0000526 ! has part afferent neuron [Term] id: UBERON:0001032 name: sensory system +def: "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information." [Wikipedia:Sensory_system] +xref: AAO:0000555 +xref: BAMS:SEN +xref: BILA:0000099 +xref: EFO:0000805 +xref: EHDAA2:0003094 +xref: EMAPA:16192 +xref: FMA:75259 +xref: MA:0002442 +xref: MAT:0000031 +xref: MIAA:0000031 +xref: NLXANAT:090816 +xref: TAO:0000282 +xref: VHOG:0001674 +xref: Wikipedia:Sensory_system +xref: XAO:0003194 +xref: ZFA:0000282 is_a: UBERON:0015203 ! non-connected functional system relationship: BFO:0000050 UBERON:0004456 ! part of entire sense organ system relationship: RO:0002131 UBERON:0001016 ! overlaps nervous system @@ -33356,6 +45220,20 @@ relationship: RO:0002216 GO:0007600 ! capable of part of sensory perception [Term] id: UBERON:0001040 name: yolk sac +def: "A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]." [Wikipedia:Yolk_sac] +xref: BTO:0001471 +xref: CALOHA:TS-1130 +xref: EFO:0003078 +xref: EHDAA2:0002212 +xref: EHDAA:164 +xref: EMAPA:16085 +xref: FMA:87180 +xref: GAID:1301 +xref: MESH:D015017 +xref: NCIT:C14128 +xref: SCTID:362845002 +xref: VHOG:0000830 +xref: Wikipedia:Yolk_sac is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0005631 ! extraembryonic membrane is_a: UBERON:0007499 ! epithelial sac @@ -33365,11 +45243,48 @@ relationship: RO:0002254 UBERON:0004872 ! splanchnic layer of lateral plate meso [Term] id: UBERON:0001041 name: foregut +def: "Anterior subdivision of a digestive tract." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0011042 +xref: BILA:0000085 +xref: BTO:0000507 +xref: EHDAA2:0000557 +xref: EHDAA:520 +xref: EMAPA:16548 +xref: FMA:45616 +xref: MA:0001526 +xref: NCIT:C34180 +xref: SCTID:361409009 +xref: TGMA:0001014 +xref: VHOG:0000285 +xref: Wikipedia:Foregut +xref: XAO:0000232 is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0001042 name: chordate pharynx +def: "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]." [http://www.feedexp.org] +comment: Consider generalizing to deuterostome pharynx +xref: AAO:0000967 +xref: BTO:0001049 +xref: CALOHA:TS-0785 +xref: EFO:0000836 +xref: EHDAA2:0001458 +xref: EHDAA:2947 +xref: EMAPA:16706 +xref: EV:0100065 +xref: FMA:46688 +xref: GAID:155 +xref: galen:Pharynx +xref: MA:0000432 +xref: MESH:D010614 +xref: NCIT:C12425 +xref: SCTID:181211006 +xref: TAO:0000056 +xref: VHOG:0000462 +xref: Wikipedia:Pharynx +xref: XAO:0003227 +xref: ZFA:0000056 is_a: UBERON:0006562 ! pharynx relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: distally_connected_to UBERON:0001043 {gci_filler="NCBITaxon:7742", gci_relation="BFO:0000050"} ! esophagus @@ -33381,41 +45296,216 @@ relationship: RO:0002551 UBERON:0008895 {gci_filler="NCBITaxon:89593", gci_relat [Term] id: UBERON:0001043 name: esophagus +def: "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993)." [http://www.rivm.nl/interspeciesinfo/inter/oesophagus/, Wikipedia:Esophagus] +xref: AAO:0000145 +xref: ANISEED:1235301 +xref: BTO:0000959 +xref: CALOHA:TS-0700 +xref: EFO:0000835 +xref: EHDAA2:0001285 +xref: EHDAA:2937 +xref: EMAPA:16833 +xref: EV:0100069 +xref: FMA:7131 +xref: GAID:291 +xref: galen:Esophagus +xref: MA:0000352 +xref: MAT:0000048 +xref: MESH:D004947 +xref: MIAA:0000048 +xref: NCIT:C12389 +xref: SCTID:181245004 +xref: TAO:0000204 +xref: VHOG:0000450 +xref: Wikipedia:Esophagus +xref: XAO:0000127 +xref: ZFA:0000204 is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0005178 ! thoracic cavity element is_a: UBERON:0013765 ! digestive system element relationship: BFO:0000050 UBERON:0004908 ! part of upper digestive tract relationship: proximally_connected_to UBERON:0001042 ! chordate pharynx relationship: RO:0002202 UBERON:0001041 ! foregut -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001045 +name: midgut +def: "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]." [GO:0007494, Wikipedia:Midgut] +xref: BILA:0000086 +xref: BTO:0000863 +xref: EFO:0001950 +xref: EHDAA2:0001185 +xref: EHDAA:983 +xref: EMAPA:16255 +xref: FMA:45617 +xref: MA:0001564 +xref: NCIT:C34210 +xref: SCTID:361410004 +xref: TGMA:0001036 +xref: VHOG:0000290 +xref: Wikipedia:Midgut +xref: XAO:0000103 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: proximally_connected_to UBERON:0001041 ! foregut + +[Term] +id: UBERON:0001046 +name: hindgut +def: "The caudalmost subdivision of a digestive tract." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0011052 +xref: BILA:0000087 +xref: BTO:0000510 +xref: EHDAA2:0000779 +xref: EHDAA:975 +xref: EMAPA:16715 +xref: FMA:45618 +xref: MA:0001527 +xref: NCIT:C34188 +xref: SCTID:362856002 +xref: TGMA:0001020 +xref: VHOG:0000459 +xref: Wikipedia:Hindgut +xref: XAO:0000104 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: proximally_connected_to UBERON:0001045 ! midgut +relationship: RO:0002202 UBERON:0003104 ! mesenchyme [Term] id: UBERON:0001048 name: primordium +def: "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]." [BTO:0001886, FB:DJS, FB:FBrf0089570, http://flybase.org/reports/FBrf0178740.html] +xref: AEO:0000171 +xref: BTO:0001886 +xref: EFO:0001652 +xref: EHDAA2:0003171 +xref: FMA:86589 +xref: MAT:0000482 +xref: NCIT:C34275 +xref: Wikipedia:Primordium +xref: XAO:0003043 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism [Term] id: UBERON:0001049 name: neural tube +def: "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]." [Wikipedia:Neural_tube] +xref: AAO:0010617 +xref: BTO:0001057 +xref: CALOHA:TS-2371 +xref: DHBA:10154 +xref: EHDAA2:0001254 +xref: EHDAA:2869 +xref: EHDAA:908 +xref: EMAPA:16164 +xref: EMAPA:16757 +xref: FMA:293882 +xref: MAT:0000069 +xref: MIAA:0000069 +xref: NCIT:C34226 +xref: neuronames:1365 +xref: SCTID:362852000 +xref: TAO:0001135 +xref: VHOG:0000307 +xref: Wikipedia:Neural_tube +xref: XAO:0003204 +xref: ZFA:0001135 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0016879 ! future central nervous system relationship: RO:0002202 UBERON:0005068 ! neural rod +[Term] +id: UBERON:0001052 +name: rectum +def: "The terminal portion of the intestinal tube, terminating with the anus." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MP:0000492] +xref: AAO:0010401 +xref: BTO:0001158 +xref: CALOHA:TS-1180 +xref: EFO:0000848 +xref: EHDAA2:0001592 +xref: EHDAA:5836 +xref: EMAPA:17896 +xref: EV:0100081 +xref: FMA:14544 +xref: GAID:311 +xref: galen:Rectum +xref: MA:0000336 +xref: MAT:0000050 +xref: MESH:D012007 +xref: MIAA:0000050 +xref: NCIT:C12390 +xref: SCTID:181261002 +xref: VHOG:0001751 +xref: Wikipedia:Rectum +xref: XAO:0000238 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract +relationship: BFO:0000050 UBERON:0012361 ! part of internal anal region +relationship: BSPO:0001108 UBERON:0000059 ! large intestine +relationship: RO:0002150 UBERON:0001159 ! sigmoid colon +relationship: RO:0002433 UBERON:0000059 ! large intestine + [Term] id: UBERON:0001062 name: anatomical entity +def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [FMA:62955, http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010841 +xref: AEO:0000000 +xref: BFO:0000004 +xref: BILA:0000000 +xref: BIRNLEX:6 +xref: CARO:0000000 +xref: EHDAA2:0002229 +xref: FMA:62955 +xref: HAO:0000000 +xref: MA:0000001 +xref: NCIT:C12219 +xref: TAO:0100000 +xref: TGMA:0001822 +xref: WBbt:0000100 +xref: XAO:0000000 +xref: ZFA:0100000 relationship: BFO:0000050 UBERON:0003942 {gci_relation="RO:0002216", gci_filler="GO:0050975"} ! part of somatosensory system relationship: BFO:0000050 UBERON:0003942 {gci_relation="RO:0002216", gci_filler="GO:0019233"} ! part of somatosensory system -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 + +[Term] +id: UBERON:0001064 +name: ventral pancreatic duct +def: "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla." [Wikipedia:Pancreatic_duct] +comment: EDITOR_NOTE in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue +xref: BTO:0002362 +xref: EHDAA2:0001396 +xref: EHDAA:6905 +xref: EMAPA:17510 +xref: FMA:16003 +xref: GAID:337 +xref: MA:0000126 +xref: MESH:D010183 +xref: NCIT:C12272 +xref: RETIRED_EHDAA2:0002177 +xref: SCTID:245385001 +xref: VHOG:0000256 +xref: Wikipedia:Pancreatic_duct +is_a: UBERON:0000025 ! tube +is_a: UBERON:0007329 ! pancreatic duct +relationship: channel_for UBERON:0001970 ! bile +relationship: channels_into UBERON:0004913 ! hepatopancreatic ampulla +relationship: RO:0002150 UBERON:0001174 ! common bile duct +relationship: RO:0002202 UBERON:0003924 ! ventral pancreatic bud [Term] id: UBERON:0001068 name: skin of back +def: "A zone of skin that is part of a back [Automatically generated definition]." [OBOL:automatic] +comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region +xref: EMAPA:36392 +xref: FMA:10462 +xref: FMA:22985 +xref: MA:0000498 +xref: SCTID:181492002 is_a: UBERON:0001085 ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum @@ -33424,36 +45514,100 @@ relationship: BFO:0000050 UBERON:0011270 ! part of dorsal trunk [Term] id: UBERON:0001070 name: external carotid artery +def: "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]." [MGI:anna] +xref: AAO:0010218 +xref: AAO:0010416 +xref: BTO:0004696 +xref: EFO:0001953 +xref: EHDAA2:0000461 +xref: EMAPA:18611 +xref: FMA:10635 +xref: GAID:480 +xref: MA:0001929 +xref: MESH:D002342 +xref: NCIT:C32551 +xref: SCTID:362044002 +xref: VHOG:0000265 +xref: Wikipedia:External_carotid_artery +xref: XAO:0000345 is_a: UBERON:0005396 ! carotid artery segment relationship: BFO:0000050 UBERON:0001530 ! part of common carotid artery plus branches relationship: RO:0002202 UBERON:0001530 ! common carotid artery plus branches relationship: RO:0002380 UBERON:0001530 ! common carotid artery plus branches -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001071 name: superficial cervical artery +def: "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery." [Wikipedia:Superficial_part_of_transverse_cervical_artery] +comment: The transverse cervical artery splits into two branches, a superficial one and a deep one[WP] +xref: FMA:10665 +xref: MA:0002052 +xref: NCIT:C53005 +xref: SCTID:161746006 +xref: Wikipedia:Superficial_part_of_transverse_cervical_artery is_a: UBERON:0012320 ! cervical artery intersection_of: UBERON:0012320 ! cervical artery intersection_of: BFO:0000050 UBERON:0035549 ! part of vasculature of integument relationship: BFO:0000050 UBERON:0035549 ! part of vasculature of integument relationship: RO:0002170 UBERON:0012324 ! transverse cervical artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001072 name: inferior vena cava +def: "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Inferior_vena_cava] +xref: AAO:0011083 +xref: BTO:0002682 +xref: EHDAA2:0000611 +xref: EMAPA:18416 +xref: FMA:10951 +xref: GAID:548 +xref: galen:InferiorVenaCava +xref: MA:0000480 +xref: MESH:D014682 +xref: NCIT:C12815 +xref: SCTID:181369003 +xref: VHOG:0001194 +xref: Wikipedia:Inferior_vena_cava +xref: XAO:0000388 is_a: UBERON:0004087 ! vena cava intersection_of: UBERON:0004087 ! vena cava intersection_of: RO:0002179 UBERON:0000154 ! posterior region of body relationship: channels_into UBERON:0002078 {gci_filler="NCBITaxon:40674", gci_relation="BFO:0000050"} ! right cardiac atrium relationship: RO:0002170 UBERON:0002078 ! right cardiac atrium relationship: RO:0002179 UBERON:0000154 ! posterior region of body -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001073 +name: ileocecal junction +def: "A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice." [http://www.medilexicon.com/medicaldictionary.php?t=46539] +xref: FMA:11338 +xref: MA:0000332 +xref: SCTID:264021000 +is_a: UBERON:8410024 ! intestinal junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0000059 ! large intestine +intersection_of: RO:0002176 UBERON:0002108 ! small intestine +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002176 UBERON:0000059 ! large intestine +relationship: RO:0002176 UBERON:0002108 ! small intestine [Term] id: UBERON:0001074 name: pericardial cavity +def: "A potential space between the visceral and parietal layers of the pericardium." [Wikipedia:Pericardium] +xref: BSA:0000091 +xref: EHDAA2:0001434 +xref: EMAPA:16131 +xref: EMAPA:16132 +xref: FMA:11350 +xref: galen:PericardialSpace +xref: MA:0000053 +xref: NCIT:C38662 +xref: SCTID:362027001 +xref: TAO:0002220 +xref: VHOG:0000556 +xref: Wikipedia:Pericardial_cavity +xref: ZFA:0001655 is_a: UBERON:0002323 ! coelemic cavity lumen is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity @@ -33467,6 +45621,14 @@ relationship: RO:0002572 UBERON:0002406 ! pericardial sac [Term] id: UBERON:0001081 name: endocardium of ventricle +def: "Endocardium that is part of the cardiac ventricle." [ZFIN:curator] +xref: EMAPA:32747 +xref: FMA:12148 +xref: MA:0000079 +xref: SCTID:192172004 +xref: TAO:0002247 +xref: VHOG:0000607 +xref: ZFA:0001615 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0002165 ! endocardium is_a: UBERON:0012275 ! meso-epithelium @@ -33478,6 +45640,10 @@ relationship: RO:0002433 UBERON:0002082 ! cardiac ventricle [Term] id: UBERON:0001082 name: epicardium of ventricle +def: "An epicardial layer that lines a cardiac ventricle." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:12150 +xref: TAO:0005058 +xref: ZFA:0005058 is_a: UBERON:0002348 ! epicardium intersection_of: UBERON:0002348 ! epicardium intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -33486,6 +45652,15 @@ relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle [Term] id: UBERON:0001083 name: myocardium of ventricle +def: "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer." [ZFIN:curator] +xref: EFO:0003088 +xref: EMAPA:32748 +xref: FMA:12151 +xref: MA:0000082 +xref: SCTID:192084000 +xref: TAO:0005061 +xref: VHOG:0000604 +xref: ZFA:0005061 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -33495,6 +45670,13 @@ relationship: RO:0002433 UBERON:0002082 ! cardiac ventricle [Term] id: UBERON:0001084 name: skin of head +def: "A zone of skin that is part of a head [Automatically generated definition]." [OBOL:automatic] +comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region +xref: FMA:12166 +xref: FMA:24756 +xref: MA:0000582 +xref: NCIT:C52757 +xref: SCTID:181484006 is_a: UBERON:0012180 ! head or neck skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -33503,6 +45685,13 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0001085 name: skin of trunk +def: "A zone of skin that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region +xref: FMA:12167 +xref: FMA:23093 +xref: MA:0000517 +xref: NCIT:C12295 +xref: SCTID:181489001 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -33511,6 +45700,13 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0001087 name: pleural fluid +def: "Transudate contained in the pleural cavity." [FMA:12273] +xref: BTO:0003080 +xref: FMA:12273 +xref: MA:0002532 +xref: MAT:0000500 +xref: ncithesaurus:Pleural_Fluid +xref: Wikipedia:Pleural_fluid is_a: UBERON:0036244 ! secretion of serous membrane intersection_of: UBERON:0007779 ! transudate intersection_of: RO:0001025 UBERON:0002402 ! pleural cavity @@ -33519,6 +45715,19 @@ relationship: RO:0001025 UBERON:0002402 ! pleural cavity [Term] id: UBERON:0001090 name: synovial fluid +def: "Joint fluid is a transudate of plasma that is actively secreted by synovial cells." [https://www.ncbi.nlm.nih.gov/books/NBK274/] +xref: BTO:0001339 +xref: CALOHA:TS-0996 +xref: ENVO:02000039 +xref: FMA:12277 +xref: GAID:265 +xref: galen:SynovialFluid +xref: MA:0002544 +xref: MESH:D013582 +xref: NCIT:C33718 +xref: TAO:0005154 +xref: Wikipedia:Synovial_fluid +xref: ZFA:0005154 is_a: UBERON:0007779 ! transudate is_a: UBERON:0007794 ! secretion of serous gland intersection_of: UBERON:0007779 ! transudate @@ -33527,9 +45736,74 @@ relationship: BFO:0000051 CHEBI:16336 ! has part relationship: RO:0001025 UBERON:0007617 ! synovial cavity of joint relationship: RO:0003001 CL:0000214 ! produced by synovial cell +[Term] +id: UBERON:0001092 +name: vertebral bone 1 +def: "The first vertebral bone in the vertebral column." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000709 +xref: EHDAA:10606 +xref: EMAPA:19431 +xref: FMA:12519 +xref: GAID:236 +xref: MA:0001421 +xref: MESH:D001270 +xref: NCIT:C32239 +xref: SCTID:181818007 +xref: TAO:0001167 +xref: Wikipedia:Atlas_(anatomy) +xref: ZFA:0001167 +is_a: UBERON:0002412 ! vertebra +relationship: BFO:0000050 UBERON:0006072 {gci_filler="NCBITaxon:32523", gci_relation="BFO:0000050"} ! part of cervical region of vertebral column +relationship: BSPO:0000096 UBERON:0001093 ! vertebral bone 2 + +[Term] +id: UBERON:0001093 +name: vertebral bone 2 +def: "The second vertebral bone in the vertebral column." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA:10608 +xref: EMAPA:19432 +xref: FMA:12520 +xref: GAID:237 +xref: MA:0001422 +xref: MESH:D001368 +xref: NCIT:C32240 +xref: SCTID:181819004 +xref: TAO:0001168 +xref: Wikipedia:Axis_(anatomy) +xref: ZFA:0001168 +is_a: UBERON:0002412 ! vertebra +relationship: anteriorly_connected_to UBERON:0001092 ! vertebral bone 1 +relationship: BFO:0000050 UBERON:0006072 {gci_filler="NCBITaxon:32523", gci_relation="BFO:0000050"} ! part of cervical region of vertebral column + +[Term] +id: UBERON:0001095 +name: caudal vertebra +def: "Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx)." [http://orcid.org/0000-0002-6601-2165] +comment: Taxon notes In zebrafish, Vertebra bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae +xref: EMAPA:18374 +xref: FMA:12527 +xref: galen:CoccygealVertebra +xref: MA:0000310 +xref: MA:0001420 +xref: NCIT:C32334 +xref: SCTID:361774004 +xref: TAO:0000326 +xref: Wikipedia:Caudal_vertebra +xref: XAO:0003079 +xref: ZFA:0000326 +is_a: UBERON:0002412 ! vertebra +is_a: UBERON:0004247 ! bone of dorsum +is_a: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002481 ! bone tissue + [Term] id: UBERON:0001096 name: wall of esophagus +def: "An anatomical wall that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35326 +xref: FMA:12611 +xref: MA:0002691 is_a: UBERON:0000328 ! gut wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -33538,15 +45812,127 @@ relationship: BFO:0000050 UBERON:0001043 ! part of esophagus [Term] id: UBERON:0001103 name: diaphragm +def: "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control." [MP:0002279] +xref: BTO:0000341 +xref: CALOHA:TS-0198 +xref: EFO:0000937 +xref: EHDAA2:0003495 +xref: EMAPA:17701 +xref: EV:0100376 +xref: FMA:13295 +xref: GAID:158 +xref: MA:0001904 +xref: MAT:0000502 +xref: MESH:D003964 +xref: NCIT:C12702 +xref: SCTID:181614006 +xref: VHOG:0000713 +xref: Wikipedia:Thoracid_diaphragm is_a: UBERON:0003830 ! thoracic segment muscle is_a: UBERON:0003831 ! respiratory system muscle relationship: RO:0002005 UBERON:0001884 ! phrenic nerve relationship: RO:0002160 NCBITaxon:40674 ! Mammalia relationship: RO:0002495 UBERON:0010084 ! future diaphragm +[Term] +id: UBERON:0001113 +name: lobe of liver +def: "Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe." [Wikipedia:Liver#Lobes] +xref: EMAPA:18306 +xref: FMA:13361 +xref: MA:0000360 +xref: NCIT:C49579 +xref: SCTID:245378000 +xref: Wikipedia:Liver#Lobes +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0009912 ! anatomical lobe +relationship: BFO:0000050 UBERON:0002107 ! part of liver + +[Term] +id: UBERON:0001114 +name: right lobe of liver +def: "The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]." [Wikipedia:Right_lobe_of_liver] +xref: EHDAA2:0001008 +xref: EHDAA:4001 +xref: EMAPA:18311 +xref: FMA:13362 +xref: MA:0000363 +xref: NCIT:C33481 +xref: SCTID:362182008 +xref: TAO:0005173 +xref: VHOG:0001424 +xref: Wikipedia:Right_lobe_of_liver +xref: ZFA:0005173 +is_a: UBERON:0001113 ! lobe of liver + +[Term] +id: UBERON:0001115 +name: left lobe of liver +def: "The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]." [Wikipedia:Left_lobe_of_liver] +xref: EHDAA2:0001000 +xref: EHDAA:3995 +xref: EMAPA:18307 +xref: FMA:13363 +xref: MA:0000361 +xref: NCIT:C32965 +xref: SCTID:362183003 +xref: TAO:0005172 +xref: VHOG:0001423 +xref: Wikipedia:Left_lobe_of_liver +xref: ZFA:0005172 +is_a: UBERON:0001113 ! lobe of liver + +[Term] +id: UBERON:0001130 +name: vertebral column +def: "Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]." [https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/tracker/?func=detail&aid=3530322&group_id=76834&atid=2257941, VSAO:0000185] +xref: AAO:0000699 +xref: AAO:0000734 +xref: BTO:0000818 +xref: EFO:0001369 +xref: EHDA:10119 +xref: EMAPA:35919 +xref: FMA:13478 +xref: GAID:106 +xref: galen:SpinalColumn +xref: MA:0002416 +xref: MESH:D013131 +xref: NCIT:C12998 +xref: NCIT:C33588 +xref: NIF_Subcellular:sao1145756102 +xref: SCTID:44300000 +xref: TAO:0001559 +xref: VHOG:0001142 +xref: VSAO:0000185 +xref: Wikipedia:Vertebral_column +xref: XAO:0003074 +xref: ZFA:0001559 +is_a: UBERON:0000075 ! subdivision of skeletal system +intersection_of: UBERON:0000075 ! subdivision of skeletal system +intersection_of: RO:0002473 UBERON:0010913 ! vertebral element +relationship: BFO:0000050 UBERON:0011138 ! part of postcranial axial skeletal system +relationship: protects UBERON:0002240 ! spinal cord +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002473 UBERON:0010913 ! vertebral element + [Term] id: UBERON:0001133 name: cardiac muscle tissue +def: "Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]." [ZFA:0005280] +xref: AAO:0010245 +xref: AEO:0000142 +xref: BILA:0000134 +xref: BTO:0000199 +xref: CALOHA:TS-0440 +xref: EHDAA2:0003142 +xref: EMAPA:32688 +xref: FMA:14068 +xref: galen:CardiacMuscle +xref: galen:CardiacMuscleTissue +xref: ncithesaurus:Heart_Muscle +xref: TAO:0005280 +xref: Wikipedia:Cardiac_muscle +xref: ZFA:0005280 is_a: UBERON:8600006 ! visceral striated muscle tissue intersection_of: UBERON:0002036 ! striated muscle tissue intersection_of: BFO:0000051 CL:0000746 ! has part cardiac muscle cell @@ -33558,6 +45944,13 @@ relationship: RO:0002473 CL:0000746 ! cardiac muscle cell [Term] id: UBERON:0001134 name: skeletal muscle tissue +def: "Muscle tissue that consists primarily of skeletal muscle fibers." [https://github.com/obophenotype/uberon/issues/324] +xref: EMAPA:32716 +xref: FMA:14069 +xref: MA:0002439 +xref: NCIT:C13050 +xref: SCTID:426215008 +xref: Wikipedia:Skeletal_striated_muscle is_a: UBERON:0002036 ! striated muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: RO:0002473 CL:0008002 ! skeletal muscle fiber @@ -33568,6 +45961,30 @@ relationship: RO:0002473 CL:0008002 ! skeletal muscle fiber [Term] id: UBERON:0001135 name: smooth muscle tissue +def: "Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]." [GO:0006939, Wikipedia:Smooth_muscle_tissue] +xref: AAO:0010244 +xref: AEO:0000141 +xref: BTO:0001260 +xref: CALOHA:TS-0943 +xref: EFO:0000889 +xref: EHDAA2:0003141 +xref: EMAPA:32717 +xref: EV:0100378 +xref: FMA:14070 +xref: GAID:167 +xref: galen:SmoothMuscle +xref: galen:SmoothMuscleTissue +xref: MA:0000166 +xref: MAT:0000303 +xref: MESH:D009130 +xref: MIAA:0000303 +xref: NCIT:C12437 +xref: TAO:0005274 +xref: VHOG:0001246 +xref: WBbt:0005781 +xref: Wikipedia:Smooth_muscle_tissue +xref: XAO:0000175 +xref: ZFA:0005274 is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: BFO:0000051 CL:0000192 ! has part smooth muscle cell @@ -33579,6 +45996,23 @@ relationship: RO:0002473 CL:0000192 ! smooth muscle cell [Term] id: UBERON:0001136 name: mesothelium +def: "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri)." [FMA:14074, Wikipedia:Mesothelium] +xref: AEO:0000111 +xref: BTO:0002422 +xref: CALOHA:TS-1183 +xref: EHDAA2_RETIRED:0003111 +xref: EHDAA:2331 +xref: EHDAA:2349 +xref: EHDAA:295 +xref: EHDAA:6073 +xref: EHDAA:640 +xref: EHDAA:646 +xref: EMAPA:32856 +xref: FMA:14074 +xref: MA:0000565 +xref: NCIT:C33105 +xref: SCTID:361918002 +xref: Wikipedia:Mesothelium is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000487 ! simple squamous epithelium @@ -33590,12 +46024,78 @@ relationship: RO:0002473 CL:0000077 ! mesothelial cell [Term] id: UBERON:0001137 name: dorsum +def: "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.." [BSPO:0000063, UBERONREF:0000006, Wikipedia:Dorsum_(anatomy)] +xref: BTO:0001713 +xref: CALOHA:TS-2223 +xref: EFO:0001405 +xref: FMA:14181 +xref: GAID:30 +xref: galen:Back +xref: MESH:D001415 +xref: NCIT:C13062 +xref: SCTID:123961009 +xref: Wikipedia:Dorsum_(anatomy) is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002160 NCBITaxon:33213 ! Bilateria +[Term] +id: UBERON:0001138 +name: superior mesenteric vein +def: "In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." [Wikipedia:Superior_mesenteric_vein] +xref: BTO:0002783 +xref: EHDAA2:0001951 +xref: EHDAA:5414 +xref: EMAPA:18643 +xref: FMA:14332 +xref: MA:0002179 +xref: NCIT:C33687 +xref: SCTID:278031001 +xref: VHOG:0000552 +xref: Wikipedia:Superior_mesenteric_vein +is_a: UBERON:0005617 ! mesenteric vein +intersection_of: UBERON:0005617 ! mesenteric vein +intersection_of: RO:0002179 UBERON:0002108 ! small intestine +relationship: BFO:0000050 UBERON:0005806 ! part of portal system +relationship: RO:0002170 UBERON:0001639 ! hepatic portal vein +relationship: RO:0002179 UBERON:0002108 ! small intestine +relationship: RO:0002202 UBERON:0005487 ! vitelline vein + +[Term] +id: UBERON:0001143 +name: hepatic vein +def: "Vein that carries blood away from the liver[ZFA]." [https://sourceforge.net/tracker/?func=detail&aid=3565355&group_id=76834&atid=1205376, Wikipedia:Hepatic_vein, ZFA:0000670] +xref: AAO:0010216 +xref: EMAPA:19221 +xref: FMA:14337 +xref: GAID:534 +xref: galen:HepaticVein +xref: MA:0003015 +xref: MESH:D006503 +xref: NCIT:C32736 +xref: SCTID:278191001 +xref: TAO:0000670 +xref: Wikipedia:Hepatic_vein +xref: XAO:0000387 +xref: ZFA:0000670 +is_a: UBERON:0013126 ! vein of abdomen +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001638 ! vein +intersection_of: RO:0002179 UBERON:0002107 ! liver +disjoint_from: UBERON:0001639 ! hepatic portal vein +relationship: BFO:0000050 UBERON:0006877 ! part of vasculature of liver +relationship: RO:0002179 UBERON:0002107 ! liver +relationship: RO:0002376 UBERON:0001072 ! inferior vena cava + [Term] id: UBERON:0001145 name: ovarian vein +def: "A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries." [Wikipedia:Ovarian_vein] +xref: EMAPA:18644 +xref: FMA:14346 +xref: MA:0002186 +xref: NCIT:C53058 +xref: SCTID:278193003 +xref: Wikipedia:Ovarian_vein is_a: UBERON:0001638 ! vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001638 ! vein @@ -33603,18 +46103,342 @@ intersection_of: RO:0002179 UBERON:0000992 ! ovary relationship: BSPO:0000126 UBERON:0000468 ! multicellular organism relationship: RO:0002179 UBERON:0000992 ! ovary +[Term] +id: UBERON:0001152 +name: cystic duct +def: "The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct." [ISBN:0-683-40008-8, MP:0009493] +xref: EHDAA2:0000333 +xref: EHDAA:3045 +xref: EMAPA:16841 +xref: FMA:14539 +xref: GAID:290 +xref: galen:CysticDuct +xref: MA:0000355 +xref: MESH:D003549 +xref: NCIT:C32421 +xref: SCTID:245398005 +xref: TAO:0005166 +xref: VHOG:0000213 +xref: Wikipedia:Cystic_duct +xref: ZFA:0005166 +is_a: UBERON:0003703 ! extrahepatic bile duct +intersection_of: UBERON:0000058 ! duct +intersection_of: RO:0002150 UBERON:0001174 ! common bile duct +intersection_of: RO:0002150 UBERON:0002110 ! gallbladder +disjoint_from: UBERON:0005171 ! hepatic duct +relationship: channels_into UBERON:0001174 ! common bile duct +relationship: RO:0002150 UBERON:0001174 ! common bile duct +relationship: RO:0002150 UBERON:0002110 ! gallbladder +relationship: RO:0002202 UBERON:0005604 ! extrahepatic part of hepatic duct + +[Term] +id: UBERON:0001155 +name: colon +def: "A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal." [http://orcid.org/0000-0002-2825-0621, http://orcid.org/0000-0002-6601-2165, Wikipedia:Colon_(anatomy), ZFIN:curator] +xref: AAO:0010400 +xref: BTO:0000269 +xref: CALOHA:TS-0158 +xref: EFO:0000361 +xref: EMAPA:18939 +xref: EV:0100079 +xref: FMA:14543 +xref: GAID:309 +xref: galen:Colon +xref: MA:0000335 +xref: MAP:0000001 +xref: MAT:0000526 +xref: MESH:D003106 +xref: NCIT:C12382 +xref: SCTID:302508007 +xref: TAO:0000706 +xref: VHOG:0000648 +xref: Wikipedia:Colon_(anatomy) +xref: XAO:0000243 +xref: ZFA:0000706 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002433 UBERON:0000059 ! large intestine + +[Term] +id: UBERON:0001159 +name: sigmoid colon +def: "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." [Wikipedia:Sigmoid_colon] +xref: BTO:0000645 +xref: CALOHA:TS-2044 +xref: EFO:0000846 +xref: EMAPA:36391 +xref: FMA:14548 +xref: galen:SigmoidColon +xref: MAT:0000314 +xref: MESH:D012809 +xref: MIAA:0000314 +xref: NCIT:C12384 +xref: NCIT:C33550 +xref: SCTID:362166007 +xref: Wikipedia:Sigmoid_colon +is_a: UBERON:0000168 ! proximal-distal subdivision of colon +relationship: RO:0002150 UBERON:0001052 ! rectum +relationship: RO:0002202 UBERON:0001046 ! hindgut + +[Term] +id: UBERON:0001161 +name: body of stomach +def: "The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]." [GO:0014845, Wikipedia:Body_of_stomach] +xref: BTO:0000505 +xref: EMAPA:35810 +xref: FMA:14560 +xref: galen:GastricCorpus +xref: MA:0002559 +xref: NCIT:C12258 +xref: SCTID:362140009 +xref: Wikipedia:Body_of_stomach +is_a: UBERON:0009870 ! zone of stomach + +[Term] +id: UBERON:0001165 +name: pyloric antrum +def: "The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells." [ISBN:0-683-40008-8, MP:0010790] +xref: BTO:0001732 +xref: EFO:0002555 +xref: EMAPA:17891 +xref: FMA:14579 +xref: GAID:332 +xref: galen:PyloricAntrum +xref: MA:0001624 +xref: MESH:D011706 +xref: NCIT:C12259 +xref: SCTID:362142001 +xref: Wikipedia:Pyloric_antrum +is_a: UBERON:0009870 ! zone of stomach +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000051 CL:0000502 ! has part type D enteroendocrine cell +relationship: BFO:0000051 CL:0000508 ! has part type G enteroendocrine cell +relationship: RO:0002150 UBERON:0001161 ! body of stomach +relationship: RO:0002433 UBERON:0001166 ! pylorus + +[Term] +id: UBERON:0001166 +name: pylorus +def: "The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum." [MGI:csmith, MP:0010785] +xref: BTO:0001146 +xref: EHDAA2:0001580 +xref: EHDAA:4860 +xref: EMAPA:17631 +xref: FMA:14581 +xref: GAID:333 +xref: galen:Pylorus +xref: MA:0002560 +xref: MESH:D011708 +xref: NCIT:C12260 +xref: SCTID:362143006 +xref: VHOG:0000420 +xref: Wikipedia:Pylorus +is_a: UBERON:0009870 ! zone of stomach +intersection_of: UBERON:0009870 ! zone of stomach +intersection_of: BFO:0000051 UBERON:0001165 ! has part pyloric antrum +intersection_of: BFO:0000051 UBERON:0008858 ! has part pyloric canal +intersection_of: BFO:0000051 UBERON:0008861 ! has part pyloric gastric gland +relationship: BFO:0000051 UBERON:0001165 ! has part pyloric antrum +relationship: BFO:0000051 UBERON:0008858 ! has part pyloric canal +relationship: BFO:0000051 UBERON:0008861 ! has part pyloric gastric gland +relationship: RO:0002433 UBERON:0000945 ! stomach + [Term] id: UBERON:0001167 name: wall of stomach +def: "The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between." [MGI:csmith, MP:0010783] +xref: EMAPA:35826 +xref: FMA:14582 +xref: galen:WallOfStomach +xref: MA:0002692 +xref: SCTID:279995000 is_a: UBERON:0000328 ! gut wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0000945 ! part of stomach relationship: RO:0002433 UBERON:0000945 ! stomach +[Term] +id: UBERON:0001168 +name: wall of small intestine +def: "An anatomical wall that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35785 +xref: FMA:14615 +xref: MA:0002696 +xref: NCIT:C33573 +is_a: UBERON:0001262 ! wall of intestine +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: UBERON:0001169 +name: wall of large intestine +def: "An anatomical wall that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35470 +xref: FMA:14619 +xref: MA:0002695 +is_a: UBERON:0001262 ! wall of intestine +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine + +[Term] +id: UBERON:0001170 +name: mesentery of small intestine +def: "The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]." [Wikipedia:Mesentery#Mesentery_.28proper.29] +xref: FMA:14643 +xref: MA:0001555 +xref: SCTID:245456008 +xref: Wikipedia:Mesentery#Mesentery_.28proper.29 +is_a: UBERON:0001206 ! serosa of small intestine +is_a: UBERON:0004854 ! gastrointestinal system mesentery +is_a: UBERON:0007826 ! peritoneal mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: UBERON:0001171 +name: portal lobule +def: "The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." [MP:0008992] +xref: FMA:14653 +xref: MA:0002498 +xref: NCIT:C33341 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0009911 ! lobule +relationship: BFO:0000050 UBERON:0001280 ! part of liver parenchyma +relationship: RO:0002433 UBERON:0001280 ! liver parenchyma + +[Term] +id: UBERON:0001172 +name: hepatic acinus +def: "The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids." [http://orcid.org/0000-0002-6601-2165, http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_acinus.html] +xref: EMAPA:35497 +xref: FMA:14654 +xref: MA:0002496 +xref: NCIT:C32992 +xref: SCTID:272214009 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0011858 ! acinus of exocrine gland +relationship: BFO:0000050 UBERON:0001280 ! part of liver parenchyma +relationship: RO:0002131 UBERON:0001171 ! overlaps portal lobule +relationship: RO:0002131 UBERON:0004647 ! overlaps liver lobule + +[Term] +id: UBERON:0001173 +name: biliary tree +def: "A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder." [DOI:10.1002/ar.20664] +comment: The path in many species is as follows: Bile canaliculi -> Canals of Hering (intralobar bile duct) -> interlobular bile ducts -> intrahepatic bile ducts -> left and right hepatic ducts merge to form -> common hepatic duct *exits liver* and joins -> cystic duct (from gall bladder) forming -> common bile duct -> joins with pancreatic duct -> forming ampulla of Vater -> enters duodenum [WP] +xref: AAO:0011020 +xref: EMAPA:35172 +xref: FMA:14665 +xref: SCTID:181267003 +xref: Wikipedia:Biliary_tract +xref: XAO:0000455 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0000062 ! organ +intersection_of: BFO:0000050 UBERON:0002294 ! part of biliary system +intersection_of: RO:0002473 UBERON:0002394 ! bile duct +relationship: BFO:0000050 UBERON:0002294 ! part of biliary system +relationship: BFO:0000051 UBERON:0001246 ! has part interlobular bile duct +relationship: BFO:0000051 UBERON:0001282 ! has part intralobular bile duct +relationship: BFO:0000051 UBERON:0003703 ! has part extrahepatic bile duct +relationship: RO:0002202 UBERON:0004912 ! biliary bud +relationship: RO:0002433 UBERON:0002423 ! hepatobiliary system +relationship: RO:0002473 UBERON:0002394 ! bile duct + +[Term] +id: UBERON:0001174 +name: common bile duct +def: "The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct." [MGI:csmith, MP:0009495] +xref: EHDAA2:0000303 +xref: EHDAA:3981 +xref: EMAPA:17201 +xref: FMA:14667 +xref: GAID:282 +xref: galen:CommonBileDuct +xref: MA:0001631 +xref: MESH:D003135 +xref: NCIT:C12698 +xref: SCTID:362199009 +xref: TAO:0005165 +xref: VHOG:0000214 +xref: Wikipedia:Common_bile_duct +xref: ZFA:0005165 +is_a: UBERON:0003703 ! extrahepatic bile duct +relationship: channels_into UBERON:0001064 ! ventral pancreatic duct +relationship: RO:0002150 UBERON:0001152 ! cystic duct +relationship: RO:0002150 UBERON:0001175 ! common hepatic duct + +[Term] +id: UBERON:0001175 +name: common hepatic duct +def: "Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]." [Wikipedia:Common_hepatic_duct, ZFIN:curator] +xref: EMAPA:19101 +xref: FMA:14668 +xref: GAID:286 +xref: MA:0002660 +xref: MESH:D006500 +xref: NCIT:C32356 +xref: SCTID:245403006 +xref: VHOG:0000220 +xref: Wikipedia:Common_hepatic_duct +is_a: UBERON:0003703 ! extrahepatic bile duct +relationship: BFO:0000050 UBERON:0005604 ! part of extrahepatic part of hepatic duct +relationship: channels_into UBERON:0001174 ! common bile duct +relationship: RO:0002150 UBERON:0001176 ! right hepatic duct +relationship: RO:0002150 UBERON:0001177 ! left hepatic duct +relationship: RO:0002495 UBERON:0010081 ! future common hepatic duct + +[Term] +id: UBERON:0001176 +name: right hepatic duct +def: "The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct." [http://www.medterms.com/script/main/art.asp?articlekey=26034] +xref: EHDAA2:0001727 +xref: EHDAA:3992 +xref: EMAPA:32797 +xref: FMA:14669 +xref: MA:0001639 +xref: NCIT:C33476 +xref: SCTID:245401008 +xref: VHOG:0000217 +is_a: UBERON:0003703 ! extrahepatic bile duct +intersection_of: UBERON:0003703 ! extrahepatic bile duct +intersection_of: RO:0002150 UBERON:0001114 ! right lobe of liver +relationship: BFO:0000050 UBERON:0005171 ! part of hepatic duct +relationship: RO:0002150 UBERON:0001114 ! right lobe of liver + +[Term] +id: UBERON:0001177 +name: left hepatic duct +def: "The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct." [http://www.medterms.com/script/main/art.asp?articlekey=26035] +xref: EHDAA2:0000941 +xref: EHDAA:3990 +xref: EMAPA:32795 +xref: FMA:14670 +xref: MA:0001638 +xref: NCIT:C32960 +xref: SCTID:245400009 +xref: VHOG:0000218 +is_a: UBERON:0003703 ! extrahepatic bile duct +intersection_of: UBERON:0003703 ! extrahepatic bile duct +intersection_of: RO:0002150 UBERON:0001115 ! left lobe of liver +relationship: BFO:0000050 UBERON:0005171 ! part of hepatic duct +relationship: RO:0002150 UBERON:0001115 ! left lobe of liver + [Term] id: UBERON:0001178 name: visceral peritoneum +def: "The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Peritoneum#Types] +xref: EMAPA:16592 +xref: FMA:14703 +xref: SCTID:362702003 +xref: TAO:0005132 +xref: VHOG:0001528 +xref: Wikipedia:Visceral_peritoneum +xref: ZFA:0005132 is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0022350 ! visceral serous membrane intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum @@ -33623,6 +46447,18 @@ relationship: BFO:0000050 UBERON:0002358 ! part of peritoneum [Term] id: UBERON:0001179 name: peritoneal cavity +def: "Anatomical cavity bounded by visceral and parietal peritoneum." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/86, Wikipedia:Peritoneal_cavity] +xref: BTO:0001782 +xref: EHDAA2:0001446 +xref: EMAPA:16138 +xref: FMA:14704 +xref: GAID:24 +xref: MA:0000054 +xref: MESH:D010529 +xref: NCIT:C12769 +xref: SCTID:181616008 +xref: VHOG:0000852 +xref: Wikipedia:Peritoneal_cavity is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002220 UBERON:0001178 ! adjacent to visceral peritoneum @@ -33637,16 +46473,75 @@ relationship: RO:0002572 UBERON:0035820 ! peritoneal sac [Term] id: UBERON:0001190 name: ovarian artery +def: "An artery that supplies an ovary." [OBOL:automatic] +xref: EMAPA:18620 +xref: FMA:14761 +xref: MA:0002012 +xref: NCIT:C33242 +xref: SCTID:244280002 +xref: Wikipedia:Ovarian_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0000992 ! ovary relationship: RO:0002170 UBERON:0001516 ! abdominal aorta relationship: RO:0002178 UBERON:0000992 ! ovary -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001193 +name: hepatic artery +def: "An artery that supplies the liver." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Hepatic_artery_proper] +xref: BTO:0004307 +xref: EMAPA:17859 +xref: FMA:14769 +xref: GAID:496 +xref: galen:HepaticArtery +xref: MA:0001963 +xref: MESH:D006499 +xref: NCIT:C32729 +xref: SCTID:76015000 +xref: TAO:0005161 +xref: ZFA:0005161 +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0002107 ! liver +relationship: RO:0002178 UBERON:0002107 ! liver + +[Term] +id: UBERON:0001194 +name: splenic artery +def: "An artery that supplies the spleen." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:19216 +xref: FMA:14773 +xref: GAID:510 +xref: galen:SplenicArtery +xref: MA:0001991 +xref: MA:0003177 +xref: MESH:D013157 +xref: NCIT:C33597 +xref: SCTID:244266009 +xref: Wikipedia:Splenic_artery +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0002106 ! spleen +disjoint_from: UBERON:0001640 ! celiac artery +relationship: RO:0002178 UBERON:0002106 ! spleen +relationship: RO:0002252 UBERON:0001640 ! celiac artery [Term] id: UBERON:0001199 name: mucosa of stomach +def: "The mucosal layer that lines the stomach." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0001308 +xref: CALOHA:TS-0404 +xref: EMAPA:35817 +xref: FMA:14907 +xref: GAID:321 +xref: galen:GastricMucosa +xref: MA:0002683 +xref: MESH:D005753 +xref: NCIT:C32656 +xref: SCTID:362131005 +xref: Wikipedia:Gastric_mucosa is_a: UBERON:0004786 ! gastrointestinal system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach @@ -33657,6 +46552,13 @@ relationship: RO:0002433 UBERON:0001167 ! wall of stomach [Term] id: UBERON:0001200 name: submucosa of stomach +def: "The fibrous connective tissue layer beneath the stomach mucosa." [MGI:csmith, MP:0010794] +xref: BTO:0002110 +xref: EMAPA:35825 +xref: FMA:14908 +xref: MA:0002685 +xref: NCIT:C32663 +xref: SCTID:52459002 is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach @@ -33666,15 +46568,356 @@ relationship: RO:0002433 UBERON:0001167 ! wall of stomach [Term] id: UBERON:0001201 name: serosa of stomach +def: "The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum." [MGI:csmith, MP:0010793] +xref: EMAPA:35822 +xref: FMA:14914 +xref: MA:0001626 +xref: NCIT:C32662 +xref: SCTID:1353004 is_a: UBERON:0004782 ! gastrointestinal system serosa intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0001167 ! part of wall of stomach relationship: BFO:0000050 UBERON:0001167 ! part of wall of stomach relationship: RO:0002433 UBERON:0001167 ! wall of stomach +[Term] +id: UBERON:0001202 +name: pyloric sphincter +def: "A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0011093 +xref: EMAPA:19251 +xref: FMA:14916 +xref: MA:0002952 +xref: NCIT:C33433 +xref: SCTID:268073008 +xref: VHOG:0001466 +xref: XAO:0000457 +is_a: UBERON:0011185 ! gastrointestinal sphincter +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: RO:0002150 UBERON:0008858 ! pyloric canal +relationship: RO:0002220 UBERON:0002114 ! adjacent to duodenum +relationship: RO:0002433 UBERON:0001166 ! pylorus + +[Term] +id: UBERON:0001204 +name: mucosa of small intestine +def: "A mucosa that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001259 +xref: CALOHA:TS-0941 +xref: EMAPA:35780 +xref: FMA:14933 +xref: MA:0002686 +xref: NCIT:C33568 +xref: SCTID:362144000 +is_a: UBERON:0001242 ! intestinal mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine +relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa + +[Term] +id: UBERON:0001205 +name: submucosa of small intestine +def: "Submucosal tissue in the small intestines." [Wikipedia:Small_intestinal_submucosa] +xref: BTO:0002112 +xref: FMA:14934 +xref: MA:0001562 +xref: NCIT:C33572 +xref: SCTID:691000 +xref: Wikipedia:Small_intestinal_submucosa +is_a: UBERON:0009566 ! intestinal submucosa +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine + +[Term] +id: UBERON:0001206 +name: serosa of small intestine +def: "A serous membrane that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14938 +xref: MA:0001558 +xref: SCTID:8266009 +is_a: UBERON:0001243 ! serosa of intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine +relationship: BFO:0000050 UBERON:0001243 ! part of serosa of intestine + +[Term] +id: UBERON:0001207 +name: mucosa of large intestine +def: "A mucosa that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: CALOHA:TS-2106 +xref: EMAPA:35467 +xref: FMA:14969 +xref: MA:0002688 +xref: NCIT:C32926 +is_a: UBERON:0001242 ! intestinal mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine +relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa + +[Term] +id: UBERON:0001208 +name: submucosa of large intestine +def: "A submucosa that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0002111 +xref: FMA:14970 +xref: MA:0002690 +xref: NCIT:C32930 +is_a: UBERON:0009566 ! intestinal submucosa +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine + +[Term] +id: UBERON:0001209 +name: serosa of large intestine +def: "A serous membrane that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14975 +xref: MA:0001546 +xref: NCIT:C32929 +is_a: UBERON:0001243 ! serosa of intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine +relationship: BFO:0000050 UBERON:0001243 ! part of serosa of intestine + +[Term] +id: UBERON:0001212 +name: duodenal gland +def: "A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]." [Wikipedia:Brunner's_glands] +xref: BTO:0002376 +xref: EMAPA:36522 +xref: FMA:15060 +xref: GAID:314 +xref: MA:0001551 +xref: MESH:D002011 +xref: NCIT:C13010 +xref: SCTID:41298001 +xref: Wikipedia:Brunner's_glands +is_a: UBERON:0003408 ! gland of digestive tract +is_a: UBERON:0011148 ! submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: RO:0001025 UBERON:0003332 ! submucosa of duodenum +relationship: RO:0002160 NCBITaxon:40674 ! Mammalia + +[Term] +id: UBERON:0001213 +name: intestinal villus +def: "The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold." [MGI:csmith, MGI:rbabiuk, MP:0008108] +xref: BTO:0003121 +xref: EMAPA:35784 +xref: FMA:15072 +xref: MA:0001563 +xref: NCIT:C33874 +xref: SCTID:23230007 +xref: TAO:0005125 +xref: Wikipedia:Intestinal_villus +xref: ZFA:0005125 +is_a: UBERON:0004923 ! organ component layer +relationship: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium +relationship: BFO:0000051 UBERON:0001981 ! has part blood vessel +relationship: BFO:0000051 UBERON:0012425 ! has part striated border microvillus layer + +[Term] +id: UBERON:0001215 +name: inferior mesenteric vein +def: "A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." [Wikipedia:Inferior_mesenteric_vein] +xref: BTO:0002782 +xref: EHDAA2:0000819 +xref: EHDAA:8712 +xref: EMAPA:18642 +xref: FMA:15391 +xref: MA:0002178 +xref: NCIT:C32782 +xref: SCTID:281055007 +xref: VHOG:0001118 +xref: Wikipedia:Inferior_mesenteric_vein +is_a: UBERON:0005617 ! mesenteric vein +intersection_of: UBERON:0005617 ! mesenteric vein +intersection_of: RO:0002179 UBERON:0000059 ! large intestine +relationship: RO:0002179 UBERON:0000059 ! large intestine +relationship: RO:0002376 UBERON:0003713 ! splenic vein + +[Term] +id: UBERON:0001238 +name: lamina propria of small intestine +def: "Lamina propria that is part_of the small intestine." [GOC:Obol] +xref: EMAPA:35779 +xref: FMA:15651 +xref: MA:0001554 +xref: NCIT:C49297 +xref: SCTID:63588008 +is_a: UBERON:0004780 ! gastrointestinal system lamina propria +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001204 ! part of mucosa of small intestine + +[Term] +id: UBERON:0001242 +name: intestinal mucosa +def: "Mucosal layer that lines the intestine." [UBERON:cjm] +xref: BTO:0000642 +xref: EMAPA:35440 +xref: FMA:15695 +xref: GAID:296 +xref: MA:0001537 +xref: MESH:D007413 +xref: NCIT:C49241 +xref: SCTID:362080002 +is_a: UBERON:0004786 ! gastrointestinal system mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine + +[Term] +id: UBERON:0001243 +name: serosa of intestine +def: "A serous membrane that is part of a wall of intestine [Automatically generated definition]." [OBOL:automatic] +xref: FMA:15701 +xref: MA:0001538 +is_a: UBERON:0004782 ! gastrointestinal system serosa +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine + +[Term] +id: UBERON:0001245 +name: anus +def: "Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts." [Wikipedia:Anus, ZFIN:curator] +xref: BTO:0001680 +xref: CALOHA:TS-2005 +xref: EV:0100082 +xref: FMA:15711 +xref: GAID:312 +xref: galen:Anus +xref: MA:0000331 +xref: NCIT:C43362 +xref: SCTID:181262009 +xref: TADS:0000066 +xref: TGMA:0001279 +xref: WBbt:0005364 +xref: Wikipedia:Anus +is_a: UBERON:0000161 ! orifice +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000161 ! orifice +intersection_of: BSPO:0001108 UBERON:0001555 ! digestive tract +relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract +relationship: BSPO:0001108 UBERON:0001555 ! digestive tract +relationship: RO:0002202 UBERON:0000931 ! proctodeum + +[Term] +id: UBERON:0001246 +name: interlobular bile duct +def: "The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad." [MP:0009500] +xref: FMA:15767 +xref: MA:0002668 +xref: NCIT:C32827 +xref: SCTID:83488001 +xref: Wikipedia:Interlobular_bile_ducts +is_a: UBERON:0003704 ! intrahepatic bile duct +relationship: BFO:0000050 UBERON:0001279 ! part of portal triad +relationship: RO:0002176 UBERON:0004058 ! biliary ductule +relationship: RO:0002176 UBERON:0014719 ! intralobular duct +relationship: RO:0002433 UBERON:0001279 ! portal triad + +[Term] +id: UBERON:0001262 +name: wall of intestine +def: "An anatomical wall that is part of a intestine [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000647 +xref: EMAPA:35444 +xref: FMA:15949 +xref: MA:0001525 +xref: MA:0002693 +xref: NCIT:C49478 +is_a: UBERON:0000328 ! gut wall +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0000160 ! part of intestine + +[Term] +id: UBERON:0001263 +name: pancreatic acinus +def: "The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct." [MP:0009145] +xref: EMAPA:35651 +xref: FMA:16011 +xref: MA:0002417 +xref: NCIT:C49268 +xref: SCTID:247604006 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0013232 ! serous acinus +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000050 UBERON:0007324 ! part of pancreatic lobule +relationship: RO:0002433 UBERON:0000017 ! exocrine pancreas +relationship: RO:0002473 CL:0002064 ! pancreatic acinar cell + +[Term] +id: UBERON:0001264 +name: pancreas +def: "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]." [GO:0031016] +xref: AAO:0010112 +xref: BTO:0000988 +xref: CALOHA:TS-0736 +xref: EFO:0000855 +xref: EHDAA2:0001367 +xref: EHDAA:6893 +xref: EMAPA:17503 +xref: EV:0100092 +xref: FMA:7198 +xref: GAID:334 +xref: galen:Pancreas +xref: MA:0000120 +xref: MAT:0000075 +xref: MESH:D010179 +xref: MIAA:0000075 +xref: NCIT:C12393 +xref: SCTID:181277001 +xref: TAO:0000140 +xref: VHOG:0000050 +xref: Wikipedia:Pancreas +xref: XAO:0000136 +xref: ZFA:0000140 +is_a: UBERON:0002075 ! viscus +relationship: BFO:0000051 UBERON:0000016 ! has part endocrine pancreas +relationship: BFO:0000051 UBERON:0000017 {gci_filler="NCBITaxon:89593", gci_relation="BFO:0000050"} ! has part exocrine pancreas +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002254 UBERON:0003923 ! dorsal pancreatic bud +relationship: RO:0002254 UBERON:0003924 ! ventral pancreatic bud + +[Term] +id: UBERON:0001265 +name: trabecula of spleen +def: "A trabecula that is part of a spleen." [OBOL:automatic] +xref: EMAPA:35808 +xref: FMA:16027 +xref: MA:0000758 +xref: NCIT:C33607 +xref: SCTID:61987002 +xref: Wikipedia:Trabeculae_of_spleen +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0000440 ! trabecula +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:1000024 ! part of parenchyma of spleen + [Term] id: UBERON:0001268 name: peritoneal fluid +def: "Transudate contained in the peritoneal cavity." [FMA:16515] +xref: BTO:0001031 +xref: EMAPA:35683 +xref: FMA:16515 +xref: MA:0002531 +xref: ncithesaurus:Peritoneal_Fluid +xref: Wikipedia:Peritoneal_fluid is_a: UBERON:0007779 ! transudate is_a: UBERON:0007794 ! secretion of serous gland is_a: UBERON:0036217 ! coelomic fluid @@ -33685,6 +46928,15 @@ relationship: RO:0001025 UBERON:0001179 ! peritoneal cavity [Term] id: UBERON:0001276 name: epithelium of stomach +def: "The epithelial layer of the stomach ." [MP:0000471] +xref: BTO:0000500 +xref: CALOHA:TS-2068 +xref: EHDAA2:0001918 +xref: EMAPA:17023 +xref: FMA:17091 +xref: MA:0001610 +xref: SCTID:64977002 +xref: VHOG:0001433 is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0004808 ! gastrointestinal system epithelium @@ -33694,9 +46946,155 @@ intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach relationship: RO:0002433 UBERON:0001199 ! mucosa of stomach +[Term] +id: UBERON:0001277 +name: intestinal epithelium +def: "Epithelial layer that lines the intestine." [UBERON:cjm] +xref: BTO:0000781 +xref: EMAPA:32873 +xref: FMA:17229 +xref: MA:0001536 +xref: NCIT:C49240 +xref: SCTID:266135004 +xref: TAO:0005124 +xref: Wikipedia:Intestinal_epithelium +xref: ZFA:0005124 +is_a: UBERON:0000485 ! simple columnar epithelium +is_a: UBERON:0003350 ! epithelium of mucosa +is_a: UBERON:0003929 ! digestive tract epithelium +is_a: UBERON:0004808 ! gastrointestinal system epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa +relationship: RO:0002433 UBERON:0000160 ! intestine + +[Term] +id: UBERON:0001278 +name: epithelium of large intestine +def: "An epithelium that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: CALOHA:TS-2105 +xref: EMAPA:35466 +xref: FMA:17301 +xref: MA:0001545 +is_a: UBERON:0001277 ! intestinal epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001207 ! part of mucosa of large intestine + +[Term] +id: UBERON:0001279 +name: portal triad +def: "A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MGI:csmith, MP:0008993] +xref: FMA:17523 +xref: MA:0002499 +xref: NCIT:C33342 +xref: SCTID:362192000 +xref: Wikipedia:Portal_triad +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0034921 ! multi organ part structure +relationship: BFO:0000050 UBERON:0001172 ! part of hepatic acinus +relationship: BFO:0000051 UBERON:0001193 ! has part hepatic artery +relationship: BFO:0000051 UBERON:0002017 ! has part portal vein +relationship: BFO:0000051 UBERON:0003704 ! has part intrahepatic bile duct +relationship: RO:0002433 UBERON:0001171 ! portal lobule + +[Term] +id: UBERON:0001280 +name: liver parenchyma +def: "The functional units of the liver including the lobules." [MP:0008986] +xref: AAO:0010405 +xref: EHDAA2:0001004 +xref: EHDAA:2201 +xref: EMAPA:17203 +xref: FMA:17540 +xref: MA:0000366 +xref: NCIT:C32735 +xref: SCTID:363535004 +xref: UMLS:C0736268 +xref: VHOG:0000539 +xref: XAO:0000454 +is_a: UBERON:0000353 ! parenchyma +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver +relationship: RO:0002202 UBERON:0008835 ! hepatic diverticulum +relationship: RO:0002433 UBERON:0002107 ! liver + +[Term] +id: UBERON:0001281 +name: hepatic sinusoid +def: "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers." [Wikipedia:Hepatic_sinusoid, ZFIN:curator] +xref: EHDAA2:0000999 +xref: EMAPA:17365 +xref: FMA:17543 +xref: MA:0000367 +xref: NCIT:C32733 +xref: SCTID:67435004 +xref: TAO:0005091 +xref: VHOG:0000708 +xref: Wikipedia:Hepatic_sinusoid +xref: ZFA:0005091 +is_a: UBERON:0003909 ! sinusoid +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0003909 ! sinusoid +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0004647 ! part of liver lobule +relationship: BFO:0000050 UBERON:0006877 ! part of vasculature of liver +relationship: RO:0002170 UBERON:0006841 ! central vein of liver +relationship: RO:0002226 UBERON:0001113 ! lobe of liver +relationship: RO:0002433 UBERON:0004647 ! liver lobule + +[Term] +id: UBERON:0001282 +name: intralobular bile duct +def: "The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule." [MGI:csmith, MP:0009499] +xref: FMA:17545 +xref: MA:0002669 +xref: NCIT:C32255 +xref: SCTID:227002 +xref: SCTID:269922006 +xref: Wikipedia:Canals_of_Hering +is_a: UBERON:0003704 ! intrahepatic bile duct +is_a: UBERON:0014716 ! interlobular duct +relationship: BFO:0000050 UBERON:0001172 ! part of hepatic acinus +relationship: BFO:0000050 UBERON:0004647 ! part of liver lobule +relationship: BFO:0000051 CL:0000182 ! has part hepatocyte +relationship: BFO:0000051 CL:1000488 ! has part cholangiocyte +relationship: RO:0002433 UBERON:0004647 ! liver lobule + +[Term] +id: UBERON:0001353 +name: anal region +def: "The anus and surrounding regions. Encompasses both internal and external regions, where present." [https://orcid.org/0000-0002-6601-2165] +xref: EFO:0000847 +xref: EHDAA2:0000122 +xref: EHDAA:2931 +xref: EMAPA:16831 +xref: MA:0000329 +xref: MAT:0000042 +xref: MIAA:0000042 +xref: NCIT:C32069 +xref: SCTID:362680001 +xref: VHOG:0000395 +xref: WBbt:0006919 +is_a: UBERON:0000475 ! organism subdivision +relationship: RO:0002131 UBERON:0006866 ! overlaps terminal part of digestive tract +relationship: RO:0002254 UBERON:0000931 ! proctodeum + [Term] id: UBERON:0001366 name: parietal peritoneum +def: "The outer layer of peritoneum that is attached to the abdominal and pelvic walls." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Peritoneum#Types] +xref: AAO:0010816 +xref: EMAPA:16591 +xref: FMA:21451 +xref: SCTID:362700006 +xref: TAO:0005131 +xref: VHOG:0001527 +xref: Wikipedia:Parietal_peritoneum +xref: ZFA:0005131 is_a: UBERON:0022351 ! parietal serous membrane intersection_of: UBERON:0022351 ! parietal serous membrane intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum @@ -33706,6 +47104,13 @@ relationship: RO:0002371 UBERON:0003697 ! abdominal wall [Term] id: UBERON:0001416 name: skin of abdomen +def: "A zone of skin that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] +xref: EFO:0000214 +xref: FMA:22988 +xref: FMA:23000 +xref: MA:0000523 +xref: NCIT:C52758 +xref: SCTID:361707007 is_a: UBERON:0003836 ! abdominal segment skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -33714,6 +47119,12 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0001417 name: skin of neck +def: "A zone of skin that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: FMA:23021 +xref: FMA:23022 +xref: MA:0000590 +xref: NCIT:C52756 +xref: SCTID:361705004 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -33722,6 +47133,11 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0001418 name: skin of thorax +def: "A zone of skin that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: FMA:23028 +xref: FMA:23029 +xref: MA:0000564 +xref: SCTID:281723000 is_a: UBERON:0001085 ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -33730,6 +47146,11 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0001421 name: pectoral girdle region +def: "An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions." [FMA:23217, https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: FMA:23217 +xref: galen:ShoulderGirdle +xref: SCTID:229759004 +xref: VSAO:0000305 is_a: UBERON:0007823 ! appendage girdle region is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0007823 ! appendage girdle region @@ -33742,16 +47163,33 @@ relationship: RO:0002551 UBERON:0007831 ! pectoral girdle skeleton [Term] id: UBERON:0001434 name: skeletal system +def: "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000027] +xref: AAO:0000566 +xref: BTO:0001486 +xref: CALOHA:TS-1320 +xref: EFO:0000806 +xref: EHDAA2:0003168 +xref: EMAPA:35773 +xref: FMA:23881 +xref: MA:0000018 +xref: NCIT:C12788 +xref: TAO:0000434 +xref: VHOG:0001254 +xref: VSAO:0000027 +xref: XAO:0003060 +xref: ZFA:0000434 is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: BFO:0000051 UBERON:0004288 ! has part skeleton intersection_of: BFO:0000051 UBERON:0004770 ! has part articular system disjoint_from: UBERON:0001474 ! bone element disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000050 UBERON:0002204 ! part of musculoskeletal system @@ -33762,12 +47200,28 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0001444 name: subdivision of head +xref: FMA:24218 +xref: SCTID:123852005 +xref: XAO:0000040 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0001456 name: face +def: "A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc)." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0003369 +xref: CALOHA:TS-2216 +xref: EMAPA:32763 +xref: FMA:24728 +xref: GAID:64 +xref: galen:Face +xref: HAO:0000316 +xref: MA:0002473 +xref: MESH:D005145 +xref: NCIT:C13071 +xref: SCTID:302549007 +xref: Wikipedia:Face is_a: UBERON:0001444 ! subdivision of head relationship: BFO:0000051 UBERON:0000018 {gci_filler="NCBITaxon:50557", gci_relation="BFO:0000050"} ! has part compound eye relationship: BFO:0000051 UBERON:0000165 ! has part mouth @@ -33778,6 +47232,11 @@ relationship: RO:0002551 UBERON:0011156 {gci_filler="NCBITaxon:7742", gci_relati [Term] id: UBERON:0001458 name: skin of lip +def: "A zone of skin that is part of a lip [Automatically generated definition]." [OBOL:automatic] +xref: FMA:24764 +xref: MA:0001579 +xref: NCIT:C12291 +xref: SCTID:244092005 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001833 ! part of lip @@ -33786,6 +47245,31 @@ relationship: BFO:0000050 UBERON:0001833 ! part of lip [Term] id: UBERON:0001474 name: bone element +def: "Skeletal element that is composed of bone tissue." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/277, PSPUB:0000170, VSAO:0000057] +xref: AAO:0000047 +xref: AEO:0000082 +xref: BTO:0000140 +xref: CALOHA:TS-0088 +xref: EFO:0000298 +xref: EHDAA2:0003082 +xref: EMAPA:32782 +xref: ENVO:00002039 +xref: EV:0100140 +xref: FMA:30317 +xref: FMA:5018 +xref: GAID:92 +xref: galen:Bone +xref: MA:0001459 +xref: MAT:0000299 +xref: MIAA:0000299 +xref: NCIT:C12366 +xref: SCTID:90780006 +xref: TAO:0001514 +xref: VHOG:0001190 +xref: VSAO:0000057 +xref: Wikipedia:Bone +xref: XAO:0000169 +xref: ZFA:0001514 is_a: UBERON:0004765 ! skeletal element intersection_of: UBERON:0004765 ! skeletal element intersection_of: RO:0002473 UBERON:0002481 ! bone tissue @@ -33797,6 +47281,16 @@ relationship: RO:0002473 UBERON:0002481 ! bone tissue [Term] id: UBERON:0001484 name: articular capsule +def: "An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]." [Wikipedia:Articular_capsule] +xref: FMA:34836 +xref: GAID:263 +xref: galen:JointCapsule +xref: MA:0001519 +xref: MESH:D017746 +xref: NCIT:C32259 +xref: NCIT:C84388 +xref: SCTID:182238002 +xref: Wikipedia:Articular_capsule is_a: UBERON:0000094 ! membrane organ intersection_of: UBERON:0000094 ! membrane organ intersection_of: BFO:0000051 UBERON:0007616 ! has part layer of synovial tissue @@ -33807,17 +47301,36 @@ relationship: RO:0002221 UBERON:0002217 ! synovial joint [Term] id: UBERON:0001496 name: ascending aorta +def: "The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]." [GO:0035905, Wikipedia:Ascending_aorta] +xref: EHDAA2:0000147 +xref: EHDAA:9828 +xref: EMAPA:17014 +xref: FMA:3736 +xref: MA:0002570 +xref: NCIT:C32150 +xref: SCTID:181299009 +xref: Wikipedia:Ascending_aorta is_a: UBERON:0001515 ! thoracic aorta relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta relationship: RO:0002202 UBERON:0005338 ! outflow tract aortic component relationship: RO:0002254 UBERON:0002061 ! truncus arteriosus relationship: RO:0002254 UBERON:0005432 ! aortic sac relationship: RO:0002433 UBERON:0001515 ! thoracic aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001508 name: arch of aorta +def: "The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery." [ISBN:0-683-40008-8, MP:0004113] +xref: BTO:0000157 +xref: EFO:0002526 +xref: EHDAA2:0000132 +xref: EMAPA:17613 +xref: FMA:3768 +xref: GAID:471 +xref: MA:0000475 +xref: SCTID:181300001 +xref: VHOG:0001196 +xref: Wikipedia:Arch_of_aorta is_a: UBERON:0001515 ! thoracic aorta relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta relationship: RO:0002170 UBERON:0001496 ! ascending aorta @@ -33825,21 +47338,38 @@ relationship: RO:0002202 UBERON:0003121 ! pharyngeal arch artery 4 relationship: RO:0002254 UBERON:0005432 ! aortic sac relationship: RO:0002254 UBERON:0005613 ! left dorsal aorta relationship: RO:0002433 UBERON:0001515 ! thoracic aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001514 name: descending aorta +def: "The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]." [GO:0035906, Wikipedia:Descending_aorta] +xref: EMAPA:18606 +xref: FMA:3784 +xref: MA:0002571 +xref: NCIT:C32455 +xref: SCTID:261399002 +xref: Wikipedia:Descending_aorta is_a: UBERON:0005800 ! section of aorta relationship: RO:0002170 UBERON:0001508 ! arch of aorta relationship: RO:0002202 UBERON:0005805 ! dorsal aorta relationship: RO:0002254 UBERON:0005613 ! left dorsal aorta relationship: RO:0002254 UBERON:0005622 ! right dorsal aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001515 name: thoracic aorta +def: "The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." [http://www.medterms.com, MP:0010468] +xref: BTO:0000157 +xref: EFO:0002525 +xref: EMAPA:18603 +xref: FMA:3786 +xref: GAID:471 +xref: galen:ThoracicAorta +xref: MA:0002569 +xref: MESH:D001013 +xref: NCIT:C33766 +xref: SCTID:302510009 +xref: Wikipedia:Thoracic_aorta is_a: UBERON:0005800 ! section of aorta intersection_of: UBERON:0005800 ! section of aorta intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -33849,139 +47379,318 @@ relationship: RO:0002433 UBERON:0000947 ! aorta [Term] id: UBERON:0001516 name: abdominal aorta +def: "Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]." [BTO:0002976, Wikipedia:Abdominal_aorta] +xref: BTO:0002976 +xref: EFO:0002524 +xref: EMAPA:17856 +xref: FMA:3789 +xref: GAID:470 +xref: galen:AbdominalAorta +xref: MA:0000474 +xref: MESH:D001012 +xref: NCIT:C32038 +xref: SCTID:244231007 +xref: Wikipedia:Abdominal_aorta is_a: UBERON:0005800 ! section of aorta relationship: BFO:0000050 UBERON:0001514 ! part of descending aorta relationship: RO:0002131 UBERON:0000916 ! overlaps abdomen relationship: RO:0002170 UBERON:0002345 ! descending thoracic aorta relationship: RO:0002433 UBERON:0001514 ! descending aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001529 name: brachiocephalic artery +def: "The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery." [MGI:csmith, MP:0010663] +xref: EFO:0002550 +xref: EHDAA2:0000835 +xref: EMAPA:17615 +xref: FMA:3932 +xref: GAID:476 +xref: galen:BrachioCephalicArtery +xref: MA:0001922 +xref: MESH:D016122 +xref: NCIT:C32814 +xref: SCTID:244244002 +xref: Wikipedia:Brachiocephalic_artery is_a: UBERON:0004573 ! systemic artery relationship: BFO:0000050 UBERON:0007204 ! part of brachiocephalic vasculature relationship: channels_from UBERON:0001508 ! arch of aorta relationship: RO:0002170 UBERON:0001508 ! arch of aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001530 name: common carotid artery plus branches +def: "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]." [Wikipedia:Common_carotid_artery] +xref: CALOHA:TS-0116 +xref: EHDAA2:0000217 +xref: EHDAA:7331 +xref: EMAPA:17855 +xref: FMA:3939 +xref: GAID:479 +xref: MA:0001926 +xref: MESH:D017536 +xref: NCIT:C32352 +xref: SCTID:362041005 +xref: VHOG:0000272 +xref: Wikipedia:Common_carotid_artery is_a: UBERON:0004573 ! systemic artery relationship: RO:0002170 UBERON:0001508 ! arch of aorta relationship: RO:0002202 UBERON:0004363 ! pharyngeal arch artery relationship: RO:0002488 UBERON:0000068 ! embryo stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001533 name: subclavian artery +def: "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584] +xref: AAO:0010232 +xref: EHDAA2:0001933 +xref: EHDAA:4357 +xref: EMAPA:17617 +xref: FMA:3951 +xref: GAID:511 +xref: MA:0002045 +xref: MESH:D013348 +xref: NCIT:C33643 +xref: SCTID:265790007 +xref: TAO:0005086 +xref: Wikipedia:Subclavian_artery +xref: XAO:0000365 +xref: ZFA:0005086 is_a: UBERON:0004573 ! systemic artery relationship: RO:0002131 UBERON:0000915 ! overlaps thoracic segment of trunk relationship: RO:0002170 UBERON:0001508 ! arch of aorta relationship: RO:0002178 UBERON:0004710 ! pectoral appendage relationship: RO:0002202 UBERON:0002457 ! intersomitic artery relationship: RO:0002202 UBERON:0005622 ! right dorsal aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001534 name: right subclavian artery +def: "The subclavian artery that supplies the right pectoral appendage." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0004514 +xref: FMA:3953 +xref: MA:0002047 +xref: NCIT:C33490 +xref: SCTID:244246000 +xref: Wikipedia:Subclavian_artery is_a: UBERON:0001533 ! subclavian artery is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001533 ! subclavian artery intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: RO:0002170 UBERON:0001529 ! brachiocephalic artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001555 name: digestive tract +def: "A tube extending from the mouth to the anus." [https://github.com/geneontology/go-ontology/issues/7549, Wikipedia:Talk\:Human_gastrointestinal_tract] +xref: AAO:0010023 +xref: BILA:0000083 +xref: BTO:0000511 +xref: BTO:0000545 +xref: EHDAA2:0000726 +xref: EHDAA:518 +xref: EMAPA:16247 +xref: FMA:45615 +xref: galen:AlimentaryTract +xref: MA:0000917 +xref: NCIT:C34082 +xref: TAO:0000112 +xref: TGMA:0001819 +xref: VHOG:0000309 +xref: WBbt:0005743 +xref: ZFA:0000112 is_a: UBERON:0000025 ! tube relationship: BFO:0000050 UBERON:0001007 ! part of digestive system relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa relationship: RO:0002176 UBERON:0000165 ! mouth relationship: RO:0002495 UBERON:0007026 ! presumptive gut -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001558 name: lower respiratory tract +def: "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lower_respiratory_tract] +xref: EHDAA2:0001036 +xref: EMAPA:16738 +xref: FMA:45662 +xref: MA:0000435 +xref: SCTID:281488008 +xref: VHOG:0000382 +xref: Wikipedia:Lower_respiratory_tract is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract relationship: BFO:0000051 UBERON:0000170 ! has part pair of lungs -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001584 name: left subclavian artery +def: "The subclavian artery that supplies the left pectoral appendage." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:4694 +xref: MA:0002046 +xref: NCIT:C32972 +xref: SCTID:244245001 +xref: Wikipedia:Subclavian_artery is_a: UBERON:0001533 ! subclavian artery is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001533 ! subclavian artery intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: channels_from UBERON:0001508 ! arch of aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001585 name: anterior vena cava +def: "A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Superior_vena_cava] +xref: BTO:0002683 +xref: EHDAA2:0001962 +xref: EHDAA:8726 +xref: EMAPA:18417 +xref: FMA:4720 +xref: GAID:549 +xref: galen:SuperiorVenaCava +xref: MA:0000481 +xref: MESH:D014683 +xref: NCIT:C12816 +xref: SCTID:181368006 +xref: VHOG:0001195 +xref: Wikipedia:Superior_vena_cava is_a: UBERON:0004087 ! vena cava intersection_of: UBERON:0004087 ! vena cava intersection_of: RO:0002179 UBERON:0000153 ! anterior region of body relationship: RO:0002170 UBERON:0002078 ! right cardiac atrium relationship: RO:0002179 UBERON:0000153 ! anterior region of body -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001586 name: internal jugular vein +def: "One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]." [Wikipedia:Internal_jugular_vein] +xref: AAO:0010236 +xref: EHDAA2:0000877 +xref: EHDAA:5407 +xref: EMAPA:17620 +xref: FMA:4724 +xref: galen:InternalJugularVein +xref: MA:0002157 +xref: NCIT:C32849 +xref: RETIRED_EHDAA2:0000878 +xref: SCTID:181372005 +xref: Wikipedia:Internal_jugular_vein +xref: XAO:0000382 is_a: UBERON:0004711 ! jugular vein relationship: RO:0002170 UBERON:0003711 ! brachiocephalic vein relationship: RO:0002179 UBERON:0000955 ! brain relationship: RO:0002179 UBERON:0001456 ! face -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001592 name: bronchial vein +def: "The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]." [Wikipedia:Bronchial_veins] +xref: EMAPA:36284 +xref: FMA:4749 +xref: MA:0002088 +xref: NCIT:C53031 +xref: SCTID:198293000 +xref: Wikipedia:Bronchial_veins is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0002185 ! bronchus relationship: RO:0002179 UBERON:0002185 ! bronchus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001605 name: ciliary muscle +def: "The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]." [Wikipedia:Ciliary_muscle] +xref: BTO:0000654 +xref: EMAPA:35240 +xref: FMA:49151 +xref: MA:0001269 +xref: NCIT:C32315 +xref: SCTID:280862009 +xref: Wikipedia:Ciliary_muscle is_a: UBERON:0003386 ! smooth muscle of eye is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0011222 ! intra-ocular muscle relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001606 name: muscle of iris +xref: FMA:49154 +xref: MA:0001287 +xref: SCTID:280888007 +xref: Wikipedia:Iris_muscle is_a: UBERON:0011222 ! intra-ocular muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000050 UBERON:0001769 ! part of iris +[Term] +id: UBERON:0001607 +name: sphincter pupillae +def: "A sphincter muscle that is part of the iris." [Wikipedia:Iris_sphincter_muscle] +xref: BTO:0000656 +xref: EMAPA:35788 +xref: FMA:49157 +xref: MA:0001289 +xref: NCIT:C33586 +xref: SCTID:280889004 +xref: Wikipedia:Iris_sphincter_muscle +is_a: UBERON:0001606 ! muscle of iris +is_a: UBERON:0004234 ! iris smooth muscle +is_a: UBERON:0007521 ! smooth muscle sphincter +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0001769 ! part of iris +relationship: RO:0002202 UBERON:0002346 ! neurectoderm +relationship: RO:0002372 UBERON:0001769 ! iris +relationship: RO:0002373 UBERON:0001769 ! iris +relationship: RO:0002568 UBERON:0001608 ! dilatator pupillae + +[Term] +id: UBERON:0001608 +name: dilatator pupillae +def: "A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]." [Wikipedia:Iris_dilator_muscle] +xref: BTO:0001371 +xref: EMAPA:35286 +xref: FMA:49158 +xref: MA:0001288 +xref: NCIT:C32463 +xref: SCTID:280890008 +xref: Wikipedia:Iris_dilator_muscle +is_a: UBERON:0004234 ! iris smooth muscle +relationship: RO:0002202 UBERON:0002346 ! neurectoderm +relationship: RO:0002372 UBERON:0001769 ! iris +relationship: RO:0002373 UBERON:0001769 ! iris +relationship: RO:0002568 UBERON:0001607 ! sphincter pupillae + [Term] id: UBERON:0001612 name: facial artery +def: "A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]." [Wikipedia:Facial_artery] +xref: EMAPA:19213 +xref: FMA:49549 +xref: MA:0001950 +xref: NCIT:C32578 +xref: SCTID:181328007 +xref: Wikipedia:Facial_artery is_a: UBERON:0035398 ! branch of external carotid artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0001456 ! face intersection_of: RO:0002252 UBERON:0001070 ! external carotid artery relationship: RO:0002178 UBERON:0001456 ! face -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001630 name: muscle organ +def: "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]." [GO:0007517] +xref: EV:0100146 +xref: FMA:5022 +xref: GAID:131 +xref: galen:Muscle +xref: MA:0000015 +xref: SCTID:71616004 +xref: TAO:0005145 +xref: VHOG:0001245 +xref: XAO:0000172 +xref: ZFA:0005145 is_a: UBERON:0000062 ! organ is_a: UBERON:0005090 ! muscle structure intersection_of: UBERON:0000062 ! organ @@ -33992,21 +47701,128 @@ relationship: RO:0002473 UBERON:0002385 ! muscle tissue [Term] id: UBERON:0001637 name: artery +def: "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." [AEO:JB] +xref: AAO:0010211 +xref: AEO:0000208 +xref: BTO:0000573 +xref: CALOHA:TS-0054 +xref: EFO:0000814 +xref: EHDAA2:0003253 +xref: EMAPA:35147 +xref: EV:0100026 +xref: FMA:50720 +xref: GAID:468 +xref: galen:Artery +xref: MA:0000064 +xref: MAT:0000034 +xref: MESH:D001158 +xref: MIAA:0000034 +xref: NCIT:C12372 +xref: SCTID:362877004 +xref: TAO:0000005 +xref: VHOG:0001251 +xref: Wikipedia:Artery +xref: XAO:0000114 +xref: ZFA:0000005 is_a: UBERON:0003509 ! arterial blood vessel relationship: channels_from UBERON:0000948 ! heart [Term] id: UBERON:0001638 name: vein +def: "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." [Wikipedia:Vein] +xref: AAO:0010212 +xref: AEO:0000209 +xref: BTO:0000234 +xref: CALOHA:TS-1108 +xref: EFO:0000816 +xref: EHDAA2:0003254 +xref: EMAPA:35906 +xref: EV:0100031 +xref: FMA:50723 +xref: GAID:492 +xref: galen:Vein +xref: MA:0000067 +xref: MAT:0000037 +xref: MESH:D014680 +xref: MIAA:0000037 +xref: NCIT:C12814 +xref: SCTID:181367001 +xref: TAO:0000082 +xref: VHOG:0001743 +xref: Wikipedia:Vein +xref: XAO:0000115 +xref: ZFA:0000082 is_a: UBERON:0003920 ! venous blood vessel intersection_of: UBERON:0003920 ! venous blood vessel intersection_of: channel_for UBERON:0013756 ! venous blood relationship: channel_for UBERON:0013756 ! venous blood relationship: channels_from UBERON:0001982 ! capillary +[Term] +id: UBERON:0001639 +name: hepatic portal vein +def: "A portal vein that transports nutrients from the digestive tract to the liver[Kardong]." [http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376, ISBN:0073040584, Wikipedia:Hepatic_portal_vein] +xref: AAO:0010214 +xref: FMA:50735 +xref: MA:0002132 +xref: TAO:0005090 +xref: VHOG:0000642 +xref: Wikipedia:Hepatic_portal_vein +xref: ZFA:0005090 +is_a: UBERON:0002017 ! portal vein +relationship: BFO:0000050 UBERON:0010194 ! part of hepatic portal system +relationship: channels_into UBERON:0002107 ! liver +relationship: RO:0002131 UBERON:0002107 ! overlaps liver + +[Term] +id: UBERON:0001640 +name: celiac artery +def: "The first major branch of the abdominal aorta." [Wikipedia:Celiac_artery] +comment: dorsal aorta in Kardong +xref: EHDAA2:0004519 +xref: EMAPA:35202 +xref: FMA:50737 +xref: GAID:483 +xref: MA:0001931 +xref: MESH:D002445 +xref: NCIT:C52846 +xref: SCTID:181340007 +xref: Wikipedia:Celiac_artery +is_a: UBERON:0012254 ! abdominal aorta artery +relationship: indirectly_supplies UBERON:0000160 ! intestine +relationship: indirectly_supplies UBERON:0000945 ! stomach +relationship: indirectly_supplies UBERON:0002106 ! spleen +relationship: indirectly_supplies UBERON:0002107 ! liver + [Term] id: UBERON:0001645 name: trigeminal nerve +def: "Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw)." [ISBN:0471209627, Wikipedia:Trigeminal_nerve] +xref: AAO:0010470 +xref: BAMS:5n +xref: BAMS:nV +xref: BAMS:Vn +xref: BIRNLEX:869 +xref: BM:VN +xref: BTO:0001072 +xref: EFO:0001402 +xref: EHDAA2:0002084 +xref: EHDAA:3738 +xref: EMAPA:17576 +xref: FMA:50866 +xref: GAID:726 +xref: MA:0001100 +xref: MBA:901 +xref: MESH:D014276 +xref: MFMO:0000093 +xref: NCIT:C12806 +xref: SCTID:362459002 +xref: TAO:0000697 +xref: VHOG:0000704 +xref: Wikipedia:Trigeminal_nerve +xref: XAO:0003092 +xref: ZFA:0000697 is_a: UBERON:0001785 ! cranial nerve intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0002925 ! trigeminal nucleus @@ -34018,40 +47834,81 @@ relationship: RO:0002134 UBERON:0000165 ! mouth relationship: RO:0002134 UBERON:0011648 ! jaw muscle relationship: RO:0002134 UBERON:1000021 ! skin of face relationship: RO:0002254 UBERON:0005239 ! basal plate metencephalon -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001651 name: right pulmonary artery +def: "The pulmonary artery that supplies the right lung." [UBERON:cjm] +xref: FMA:50872 +xref: galen:RightPulmonaryArtery +xref: MA:0002500 +xref: NCIT:C33489 +xref: SCTID:244235003 +xref: Wikipedia:Right_pulmonary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0002167 ! right lung relationship: RO:0002170 UBERON:0002333 ! pulmonary trunk relationship: RO:0002178 UBERON:0002167 ! right lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001652 name: left pulmonary artery +def: "The pulmonary artery that supplies the left lung." [UBERON:cjm] +xref: FMA:50873 +xref: galen:LeftPulmonaryArtery +xref: MA:0002032 +xref: NCIT:C32971 +xref: SCTID:244234004 +xref: Wikipedia:Left_pulmonary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0002168 ! left lung relationship: RO:0002170 UBERON:0002333 ! pulmonary trunk relationship: RO:0002178 UBERON:0002168 ! left lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001653 name: facial vein +def: "The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]." [Wikipedia:Facial_vein] +xref: AAO:0010513 +xref: EMAPA:19220 +xref: FMA:50874 +xref: MA:0002115 +xref: NCIT:C32579 +xref: SCTID:181374006 +xref: Wikipedia:Facial_vein is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009141 ! craniocervical region vein relationship: BFO:0000050 UBERON:0001456 ! part of face relationship: RO:0002376 UBERON:0001586 ! internal jugular vein -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001675 name: trigeminal ganglion +def: "The cranial ganglion that is associated with and extends fibers into the trigeminal nerve." [http://orcid.org/0000-0002-6601-2165, http://www.ncbi.nlm.nih.gov/books/NBK53171, https://github.com/obophenotype/uberon/issues/693] +xref: AAO:0011107 +xref: BAMS:5Gn +xref: BAMS:GV +xref: BTO:0001231 +xref: EFO:0000903 +xref: EHDAA2:0002085 +xref: EHDAA:2113 +xref: EMAPA:16797 +xref: FMA:52618 +xref: GAID:725 +xref: MA:0001080 +xref: MAT:0000511 +xref: MESH:D012668 +xref: NCIT:C62642 +xref: neuronames:1402 +xref: SCTID:244449009 +xref: TAO:0000295 +xref: VHOG:0000694 +xref: Wikipedia:Trigeminal_ganglion +xref: XAO:0000427 +xref: XAO:0000428 +xref: ZFA:0000295 is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0001800 ! sensory ganglion is_a: UBERON:0010313 ! neural crest-derived structure @@ -34063,6 +47920,15 @@ relationship: RO:0002495 UBERON:0006304 ! future trigeminal ganglion [Term] id: UBERON:0001676 name: occipital bone +def: "The bone at the lower, posterior part of the skull." [ISBN:0-683-40008-8, MP:0005269] +xref: EMAPA:25112 +xref: FMA:52735 +xref: GAID:227 +xref: MA:0001468 +xref: MESH:D009777 +xref: NCIT:C12757 +xref: SCTID:181796003 +xref: Wikipedia:Occipital_bone is_a: UBERON:0010428 ! flat bone is_a: UBERON:0011164 ! neurocranium bone relationship: BFO:0000050 UBERON:0005902 ! part of occipital region @@ -34071,21 +47937,110 @@ relationship: RO:0002131 UBERON:0003113 ! overlaps dermatocranium relationship: RO:0002160 NCBITaxon:117570 ! Teleostomi relationship: RO:0002202 UBERON:0003089 ! sclerotome relationship: RO:0002221 UBERON:0003687 ! foramen magnum -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001677 +name: sphenoid bone +def: "An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended." [Wikipedia:Sphenoid_bone] +xref: CALOHA:TS-2343 +xref: EMAPA:18340 +xref: FMA:52736 +xref: GAID:230 +xref: MA:0001472 +xref: MESH:D013100 +xref: NCIT:C12790 +xref: SCTID:272676008 +xref: Wikipedia:Sphenoid_bone +is_a: UBERON:0002513 ! endochondral bone +is_a: UBERON:0003462 ! facial bone +is_a: UBERON:0008193 ! pneumatized bone +is_a: UBERON:0015060 ! sphenoid endochondral element +intersection_of: UBERON:0015060 ! sphenoid endochondral element +intersection_of: RO:0002473 UBERON:0002481 ! bone tissue +relationship: RO:0002131 UBERON:0002241 ! overlaps chondrocranium +relationship: RO:0002131 UBERON:0003113 ! overlaps dermatocranium +relationship: RO:0002131 UBERON:0008895 ! overlaps splanchnocranium +relationship: RO:0002202 UBERON:0009193 ! sphenoid cartilage element + +[Term] +id: UBERON:0001679 +name: ethmoid bone +def: "A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]." [Wikipedia:Ethmoid_bone] +xref: BTO:0004140 +xref: EMAPA:19018 +xref: FMA:52740 +xref: GAID:212 +xref: MA:0001483 +xref: MESH:D005004 +xref: NCIT:C12711 +xref: SCTID:272674006 +xref: VHOG:0001317 +xref: Wikipedia:Ethmoid_bone +is_a: UBERON:0002513 ! endochondral bone +is_a: UBERON:0003462 ! facial bone +is_a: UBERON:0011164 ! neurocranium bone +relationship: BFO:0000050 UBERON:0002517 ! part of basicranium +relationship: BFO:0000050 UBERON:0011241 ! part of ethmoid region +relationship: RO:0002202 UBERON:0006227 ! ethmoid bone primordium +relationship: RO:0002433 UBERON:0011156 ! facial skeleton + +[Term] +id: UBERON:0001697 +name: orbit of skull +def: "Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball." [http://orcid.org/0000-0002-6601-2165, TAO:0001410, Wikipedia:Orbit_(anatomy)] +xref: BTO:0004687 +xref: FMA:53074 +xref: GAID:223 +xref: galen:Orbit +xref: MA:0002482 +xref: MESH:D009915 +xref: NCIT:C12347 +xref: TAO:0001410 +xref: Wikipedia:Orbit_(anatomy) +xref: XAO:0003171 +xref: ZFA:0001410 +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010912 ! subdivision of skeleton +is_a: UBERON:0015212 ! lateral structure +relationship: BFO:0000050 UBERON:0004088 ! part of orbital region +relationship: BFO:0000050 UBERON:0011156 ! part of facial skeleton +relationship: BSPO:0000126 UBERON:0011156 ! facial skeleton +relationship: RO:0001015 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0001703 name: neurocranium +def: "Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof." [PMID:11523816, TAO:MAH, Wikipedia:Neuroranium, ZFA:0001580] +xref: FMA:53672 +xref: MA:0000317 +xref: SCTID:361731002 +xref: TAO:0001580 +xref: Wikipedia:Neuroranium +xref: XAO:0003170 +xref: ZFA:0001580 is_a: UBERON:0011158 ! primary subdivision of skull relationship: BFO:0000050 UBERON:0003128 ! part of cranium relationship: protects UBERON:0000955 ! brain relationship: RO:0001015 UBERON:0000955 ! brain relationship: RO:0002202 UBERON:0004761 ! cartilaginous neurocranium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001708 name: jaw skeleton +def: "Subdivision of skeleton which includes upper and lower jaw skeletons." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Jaw] +xref: AAO:0000988 +xref: BTO:0001749 +xref: EMAPA:35455 +xref: FMA:54396 +xref: GAID:214 +xref: galen:Jaw +xref: MA:0001905 +xref: MESH:D007568 +xref: NCIT:C48821 +xref: SCTID:181811001 +xref: TAO:0001227 +xref: Wikipedia:Jaw +xref: ZFA:0001227 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton @@ -34097,9 +48052,46 @@ relationship: RO:0002160 NCBITaxon:7776 ! Gnathostomata relationship: RO:0002215 NBO:0000073 ! capable of relationship: RO:0002576 UBERON:0011595 ! jaw region +[Term] +id: UBERON:0001709 +name: upper jaw region +def: "Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Upper_jaw] +comment: See notes for jaw w.r.t skeletal element vs subdivision of head. +xref: AAO:0000620 +xref: EHDAA2:0002118 +xref: EHDAA2:0004607 +xref: EHDAA:8025 +xref: EMAPA:17924 +xref: FMA:59399 +xref: ncithesaurus:Upper_Jaw +xref: SCTID:362636001 +xref: VHOG:0000454 +xref: Wikipedia:Upper_jaw +is_a: UBERON:0000475 ! organism subdivision +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000475 ! organism subdivision +intersection_of: RO:0002551 UBERON:0003277 ! skeleton of upper jaw +disjoint_from: UBERON:0001710 ! lower jaw region +relationship: BFO:0000050 UBERON:0004089 ! part of midface +relationship: BFO:0000050 UBERON:0011595 ! part of jaw region +relationship: RO:0002551 UBERON:0003277 ! skeleton of upper jaw + [Term] id: UBERON:0001710 name: lower jaw region +def: "Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." [Wikipedia:Lower_jaw] +comment: See notes for jaw w.r.t skeletal element vs subdivision of head +xref: AAO:0000272 +xref: EFO:0003660 +xref: EHDAA2:0001018 +xref: EHDAA:7995 +xref: EMAPA:17906 +xref: FMA:59398 +xref: MESH:D008334 +xref: ncithesaurus:Lower_Jaw +xref: SCTID:362637005 +xref: VHOG:0000453 +xref: Wikipedia:Lower_jaw is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000475 ! organism subdivision @@ -34111,16 +48103,39 @@ relationship: RO:0002551 UBERON:0003278 ! skeleton of lower jaw [Term] id: UBERON:0001714 name: cranial ganglion +def: "The groups of nerve cell bodies associated with the twelve cranial nerves." [ISBN:0-683-40008-8, MGI:csmith, MP:0001081, PMID:9362461] +xref: BIRNLEX:2597 +xref: BTO:0000106 +xref: EFO:0000902 +xref: EMAPA:16659 +xref: FMA:54502 +xref: MA:0000213 +xref: MA:0000214 +xref: MAT:0000200 +xref: MIAA:0000200 +xref: SCTID:244448001 +xref: TAO:0000013 +xref: VHOG:0000076 +xref: Wikipedia:Cranial_nerve_ganglion +xref: XAO:0000027 +xref: ZFA:0000013 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0034713 ! cranial neuron projection bundle relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: extends_fibers_into UBERON:0034713 ! cranial neuron projection bundle -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001731 name: cavity of pharynx +def: "An anatomical space that is enclosed by a pharynx." [OBOL:automatic] +xref: AAO:0010435 +xref: BSA:0000113 +xref: BTO:0002097 +xref: EMAPA:18381 +xref: FMA:54935 +xref: SCTID:180543003 +xref: XAO:0000105 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0006562 ! pharynx @@ -34131,6 +48146,19 @@ relationship: RO:0002572 UBERON:0006562 ! pharynx [Term] id: UBERON:0001766 name: anterior chamber of eyeball +def: "The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens." [MESH:A09.371.060.067, MP:0005205] +xref: BTO:0002084 +xref: EHDAA2:0000129 +xref: EHDAA:9033 +xref: EMAPA:18231 +xref: FMA:58078 +xref: GAID:889 +xref: MA:0000262 +xref: MESH:D000867 +xref: NCIT:C12667 +xref: SCTID:181160009 +xref: VHOG:0001431 +xref: Wikipedia:Anterior_chamber_of_eyeball is_a: UBERON:0006311 ! chamber of eyeball relationship: BFO:0000050 UBERON:0001801 ! part of anterior segment of eyeball relationship: RO:0002433 UBERON:0001801 ! anterior segment of eyeball @@ -34138,6 +48166,16 @@ relationship: RO:0002433 UBERON:0001801 ! anterior segment of eyeball [Term] id: UBERON:0001768 name: uvea +def: "The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]." [MP:0005197, Wikipedia:Uvea] +xref: CALOHA:TS-2228 +xref: EMAPA:35901 +xref: FMA:58103 +xref: GAID:912 +xref: MA:0002480 +xref: MESH:D014602 +xref: NCIT:C12811 +xref: SCTID:280648000 +xref: Wikipedia:Uvea is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004923 ! organ component layer is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -34150,16 +48188,48 @@ relationship: RO:0002433 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0001769 name: iris +def: "The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye." [ISBN:0-683-40008-8, MP:0001322] +xref: AAO:0010347 +xref: BTO:0000653 +xref: CALOHA:TS-0491 +xref: EFO:0004245 +xref: EMAPA:19154 +xref: EV:0100345 +xref: FMA:58235 +xref: GAID:917 +xref: MA:0000273 +xref: MESH:D007498 +xref: NCIT:C12737 +xref: SCTID:181164000 +xref: TAO:0001238 +xref: VHOG:0000101 +xref: Wikipedia:Iris_(anatomy) +xref: XAO:0000185 +xref: ZFA:0001238 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0011892 ! part of anterior uvea relationship: RO:0002202 UBERON:0004128 ! optic vesicle relationship: RO:0002433 UBERON:0011892 ! anterior uvea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001772 name: corneal epithelium +def: "The smooth stratified squamous epithelium that covers the outer surface of the cornea." [MESH:A09.371.060.217.325, MGI:smb, MP:0006000] +xref: BTO:0000287 +xref: CALOHA:TS-0173 +xref: EFO:0001917 +xref: EHDAA2:0000319 +xref: EMAPA:17162 +xref: FMA:58263 +xref: GAID:895 +xref: MA:0001243 +xref: MESH:D019573 +xref: NCIT:C12928 +xref: SCTID:368825001 +xref: TAO:0002187 +xref: Wikipedia:Corneal_epithelium +xref: ZFA:0001683 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium @@ -34167,11 +48237,26 @@ intersection_of: RO:0002007 UBERON:0000964 ! bounding layer of cornea relationship: RO:0002007 UBERON:0000964 ! bounding layer of cornea relationship: RO:0002202 UBERON:0000076 ! external ectoderm relationship: RO:0002433 UBERON:0000964 ! cornea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001773 name: sclera +def: "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]." [Wikipedia:Sclera, ZFIN:ZDB-PUB-050701-15] +comment: Disease notes: implicated in rheumatoid arthritis. +xref: AAO:0010354 +xref: BTO:0001606 +xref: EMAPA:19027 +xref: EV:0100342 +xref: FMA:58269 +xref: GAID:911 +xref: MA:0000280 +xref: MESH:D012590 +xref: NCIT:C12784 +xref: SCTID:181163006 +xref: VHOG:0001274 +xref: Wikipedia:Sclera +xref: XAO:0000183 +xref: ZFA:0005563 is_a: UBERON:0000064 ! organ part is_a: UBERON:0010313 ! neural crest-derived structure relationship: BFO:0000050 UBERON:0012430 ! part of tunica fibrosa of eyeball @@ -34179,11 +48264,18 @@ relationship: BFO:0000051 CL:0000347 ! has part scleral cell relationship: RO:0000086 PATO:0000963 relationship: RO:0002202 UBERON:0003314 ! eye mesenchyme relationship: RO:0002433 UBERON:0000019 ! camera-type eye -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001774 name: skeletal muscle of trunk +def: "A skeletal muscle organ that is part of the trunk region." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000611 +xref: EMAPA:35888 +xref: FMA:58274 +xref: MA:0000514 +xref: TAO:0000473 +xref: XAO:0003230 +xref: ZFA:0000473 is_a: UBERON:0005177 ! trunk region element is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate @@ -34193,6 +48285,22 @@ relationship: BFO:0000050 UBERON:0004479 ! part of musculature of trunk [Term] id: UBERON:0001775 name: ciliary body +def: "The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes." [ISBN:0-683-40008-8, MP:0005099, Wikipedia:Ciliary_body] +xref: AAO:0010341 +xref: BTO:0000260 +xref: CALOHA:TS-0694 +xref: EMAPA:19065 +xref: EV:0100346 +xref: FMA:58295 +xref: GAID:916 +xref: MA:0000264 +xref: MESH:D002924 +xref: NCIT:C12345 +xref: neuronames:1571 +xref: SCTID:263340007 +xref: VHOG:0000102 +xref: Wikipedia:Ciliary_body +xref: XAO:0000186 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0011892 ! part of anterior uvea @@ -34200,11 +48308,25 @@ relationship: BFO:0000051 UBERON:0001605 ! has part ciliary muscle relationship: BFO:0000051 UBERON:0010427 ! has part ciliary processes relationship: RO:0002202 UBERON:0002346 ! neurectoderm relationship: RO:0002433 UBERON:0011892 ! anterior uvea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001776 name: optic choroid +def: "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." [Wikipedia:Choroid] +xref: BTO:0001829 +xref: CALOHA:TS-2054 +xref: EMAPA:19077 +xref: EV:0100347 +xref: FMA:58298 +xref: GAID:913 +xref: MA:0000263 +xref: MESH:D002829 +xref: NCIT:C12344 +xref: SCTID:181172003 +xref: TAO:0005229 +xref: VHOG:0001568 +xref: Wikipedia:Choroid +xref: ZFA:0005229 is_a: UBERON:0002203 ! vasculature of eye relationship: BFO:0000050 UBERON:0001768 ! part of uvea relationship: BFO:0000050 UBERON:0019207 ! part of chorioretinal region @@ -34213,11 +48335,23 @@ relationship: RO:0002220 UBERON:0000966 ! adjacent to retina relationship: RO:0002220 UBERON:0001773 ! adjacent to sclera relationship: RO:0002220 UBERON:0011892 ! adjacent to anterior uvea relationship: RO:0002433 UBERON:0001768 ! uvea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001777 name: substantia propria of cornea +def: "The lamellated connective tissue of the cornea between the Bowman and Descemet membranes." [ISBN:0-683-40008-8, MESH:A09.371.060.217.228, MP:0005300] +xref: CALOHA:TS-1138 +xref: EFO:0002514 +xref: EMAPA:17602 +xref: FMA:58306 +xref: GAID:893 +xref: MA:0001245 +xref: MESH:D003319 +xref: NCIT:C12699 +xref: SCTID:362511000 +xref: TAO:0002189 +xref: Wikipedia:Corneal_stroma +xref: ZFA:0001685 is_a: UBERON:0003891 ! stroma is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0003891 ! stroma @@ -34231,6 +48365,15 @@ relationship: RO:0002433 UBERON:0000964 ! cornea [Term] id: UBERON:0001778 name: ciliary epithelium +def: "A double layer covering the ciliary body that produces aqueous humor." [Wikipedia:Ciliary_body#Ciliary_epithelium] +xref: BTO:0001770 +xref: CALOHA:TS-0695 +xref: EMAPA:35239 +xref: FMA:58464 +xref: MA:0001238 +xref: NCIT:C32314 +xref: SCTID:280870004 +xref: Wikipedia:Ciliary_body#Ciliary_epithelium is_a: UBERON:0000488 ! atypical epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium @@ -34238,11 +48381,17 @@ intersection_of: BFO:0000050 UBERON:0001775 ! part of ciliary body relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body relationship: BFO:0000051 GO:0048770 ! has part pigment granule relationship: RO:0003000 UBERON:0001796 ! produces aqueous humor of eyeball -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001779 name: iris stroma +def: "The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae." [http://www.drugs.com/dict/stroma-of-iris.html, Wikipedia:Iris_stroma] +xref: EMAPA:35451 +xref: FMA:58526 +xref: MA:0002777 +xref: SCTID:280882008 +xref: Wikipedia:Iris_stroma +xref: ZFA:0005569 is_a: UBERON:0003891 ! stroma is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0003891 ! stroma @@ -34253,15 +48402,38 @@ relationship: RO:0002433 UBERON:0001769 ! iris [Term] id: UBERON:0001780 name: spinal nerve +def: "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]." [MESH:A08.800.800.720, MP:0001077] +xref: AAO:0011101 +xref: BAMS:spin +xref: BTO:0000870 +xref: EHDAA2:0001898 +xref: EMAPA:16989 +xref: FMA:5858 +xref: GAID:841 +xref: MA:0000233 +xref: MESH:D013127 +xref: NCIT:C12792 +xref: neuronames:1228 +xref: SCTID:361099009 +xref: VHOG:0000824 +xref: Wikipedia:Spinal_nerve +xref: XAO:0003101 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: extends_fibers_into UBERON:0002240 ! spinal cord relationship: extends_fibers_into UBERON:0002240 ! spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001781 name: layer of retina +def: "Any of the layers that make up the retina[MP]." [MP:0003727] +xref: AAO:0010353 +xref: EMAPA:35742 +xref: FMA:58617 +xref: MA:0001319 +xref: NCIT:C49328 +xref: SCTID:280657006 +xref: XAO:0000266 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0022303 ! nervous system cell part layer relationship: BFO:0000050 UBERON:0000966 ! part of retina @@ -34270,6 +48442,27 @@ relationship: RO:0002433 UBERON:0000966 ! retina [Term] id: UBERON:0001785 name: cranial nerve +def: "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord." [Wikipedia:Cranial_nerve] +xref: AAO:0000108 +xref: BAMS:cran +xref: BIRNLEX:1623 +xref: BTO:0001104 +xref: EHDAA2:0000323 +xref: EMAPA:17264 +xref: FMA:5865 +xref: GAID:802 +xref: MA:0000215 +xref: MBA:967 +xref: MESH:D003391 +xref: NCIT:C12700 +xref: neuronames:1227 +xref: SCTID:244447006 +xref: TAO:0000641 +xref: VHOG:0000279 +xref: Wikipedia:Cranial_nerve +xref: XAO:0000429 +xref: XAO:0003089 +xref: ZFA:0000641 is_a: UBERON:0011779 ! nerve of head region is_a: UBERON:0034713 ! cranial neuron projection bundle intersection_of: UBERON:0001021 ! nerve @@ -34277,11 +48470,24 @@ intersection_of: BSPO:0000096 UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0000955 ! brain relationship: BSPO:0000096 UBERON:0001780 ! spinal nerve relationship: RO:0002254 UBERON:0003099 ! cranial neural crest -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001796 name: aqueous humor of eyeball +def: "A thick watery refractive medium that fills the space between the lens and the cornea[WP]." [Wikipedia:Aqueous_humor] +xref: EHDAA2:0000139 +xref: EHDAA:10196 +xref: EMAPA:18232 +xref: ENVO:02000024 +xref: FMA:58819 +xref: GAID:890 +xref: MA:0001236 +xref: MESH:D001082 +xref: NCIT:C13190 +xref: SCTID:280587006 +xref: VHOG:0000548 +xref: Wikipedia:Aqueous_humor +xref: ZFA:0005564 is_a: UBERON:0006312 ! ocular refractive media is_a: UBERON:0006314 ! bodily fluid relationship: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball @@ -34290,15 +48496,31 @@ relationship: RO:0002433 UBERON:0001766 ! anterior chamber of eyeball [Term] id: UBERON:0001800 name: sensory ganglion +def: "The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells." [MP:0000960] +xref: AEO:0001000 +xref: BTO:0005630 +xref: EMAPA:36596 +xref: FMA:5885 +xref: MA:0002566 +xref: MESH:D017950 +xref: NCIT:C13060 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0001027 ! sensory nerve relationship: extends_fibers_into UBERON:0001027 ! sensory nerve -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001801 name: anterior segment of eyeball +def: "Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive)." [ISBN:0-683-40008-8, MESH:A09.371.060, MP:0005193] +xref: EMAPA:36594 +xref: FMA:58865 +xref: MA:0002484 +xref: MESH:D000869 +xref: NCIT:C12668 +xref: SCTID:280658001 +xref: Wikipedia:Anterior_segment_of_eyeball +xref: ZFA:0005566 is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye @@ -34308,6 +48530,14 @@ relationship: RO:0002433 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0001802 name: posterior segment of eyeball +def: "Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive)." [ISBN:0-683-40008-8, MP:0005195] +xref: EMAPA:36595 +xref: FMA:58868 +xref: MA:0002485 +xref: NCIT:C12906 +xref: SCTID:280659009 +xref: Wikipedia:Posterior_segment_of_eyeball +xref: ZFA:0005567 is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye @@ -34317,17 +48547,37 @@ relationship: RO:0002433 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0001803 name: epithelium of lens +def: "A layer of epithelial cells that is part of the eye." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0001873 +xref: CALOHA:TS-0543 +xref: EMAPA:32871 +xref: FMA:58871 +xref: MA:0001301 +xref: SCTID:362523006 +xref: TAO:0001326 +xref: Wikipedia:Lens_(anatomy)#Lens_Epithelium +xref: XAO:0004094 +xref: ZFA:0001326 is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: RO:0002433 UBERON:0000965 ! lens of camera-type eye -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001804 name: capsule of lens +def: "The elastic, clear, membrane-like structure, that is outer most layer of the lens." [MGI:smb, MP:0003236, PMID:15483628] +xref: EHDAA2:0000977 +xref: EMAPA:18237 +xref: FMA:58881 +xref: MA:0001300 +xref: NCIT:C32975 +xref: SCTID:244500004 +xref: VHOG:0000550 +xref: Wikipedia:Lens_(anatomy)#Lens_capsule +xref: ZFA:0005574 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005764 ! acellular membrane intersection_of: UBERON:0000476 ! acellular anatomical structure @@ -34341,16 +48591,35 @@ relationship: RO:0002202 UBERON:0005614 ! lens anterior epithelium [Term] id: UBERON:0001805 name: autonomic ganglion +def: "Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion." [Wikipedia:Autonomic_ganglion] +xref: AEO:0001001 +xref: CALOHA:TS-2340 +xref: EMAPA:18221 +xref: FMA:5889 +xref: MA:0000220 +xref: MESH:D005725 +xref: NCIT:C12720 +xref: Wikipedia:Autonomic_ganglion is_a: UBERON:0003338 ! ganglion of peripheral nervous system intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: extends_fibers_into UBERON:0034728 ! autonomic nerve -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001806 name: sympathetic ganglion +def: "A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia." [http://orcid.org/0000-0002-6601-2165, MP:0001008] +xref: AAO:0010773 +xref: BTO:0001333 +xref: CALOHA:TS-0994 +xref: EHDAA2:0001969 +xref: EMAPA:17157 +xref: FMA:5890 +xref: MA:0000226 +xref: NCIT:C12467 +xref: SCTID:362485003 +xref: Wikipedia:Sympathetic_ganglion is_a: UBERON:0001805 ! autonomic ganglion is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0000045 ! ganglion @@ -34363,14 +48632,56 @@ relationship: RO:0002433 UBERON:0000013 ! sympathetic nervous system [Term] id: UBERON:0001833 name: lip +def: "One of the two fleshy folds which surround the opening of the mouth." [http://www.medterms.com/script/main/art.asp?articlekey=9458, Wikipedia:Lip] +xref: BTO:0001647 +xref: CALOHA:TS-0558 +xref: EMAPA:32839 +xref: FMA:59816 +xref: GAID:76 +xref: galen:Lip +xref: MA:0000343 +xref: MESH:D008046 +xref: NCIT:C12220 +xref: SCTID:181221003 +xref: TAO:0007006 +xref: VHOG:0000677 +xref: Wikipedia:Lip +xref: ZFA:0007006 is_a: UBERON:0003102 ! surface structure relationship: BFO:0000050 UBERON:0000165 ! part of mouth relationship: RO:0002221 UBERON:0000166 ! oral opening relationship: RO:0002433 UBERON:0000165 ! mouth +[Term] +id: UBERON:0001834 +name: upper lip +def: "Lip that covers the upper portion of the mouth.[TAO]." [TAO:0001970, Wikipedia:Upper_lip] +xref: EMAPA:17925 +xref: FMA:59817 +xref: MA:0000919 +xref: SCTID:245776003 +xref: TAO:0001970 +xref: VHOG:0001750 +xref: Wikipedia:Upper_lip +xref: ZFA:0005226 +is_a: UBERON:0001833 ! lip +intersection_of: UBERON:0001833 ! lip +intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: RO:0002495 UBERON:0011592 ! future upper lip + [Term] id: UBERON:0001835 name: lower lip +def: "Lip that covers the lower portion of the mouth.[TAO]." [TAO:0002060, Wikipedia:Lower_lip] +xref: EMAPA:17909 +xref: FMA:59818 +xref: MA:0000921 +xref: NCIT:C94572 +xref: SCTID:245777007 +xref: TAO:0002060 +xref: Wikipedia:Lower_lip +xref: ZFA:0005225 is_a: UBERON:0001833 ! lip intersection_of: UBERON:0001833 ! lip intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region @@ -34380,26 +48691,79 @@ relationship: RO:0002202 UBERON:0011596 ! future lower lip [Term] id: UBERON:0001884 name: phrenic nerve +def: "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium." [VHOG:0000728] +xref: BAMS:phn +xref: BTO:0001063 +xref: EHDAA:4677 +xref: EMAPA:17813 +xref: FMA:6191 +xref: GAID:848 +xref: MA:0001170 +xref: MESH:D010791 +xref: NCIT:C52813 +xref: SCTID:280344009 +xref: VHOG:0000728 +xref: Wikipedia:Phrenic_nerve is_a: UBERON:0003443 ! thoracic cavity nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001103 ! diaphragm relationship: RO:0002134 UBERON:0001103 ! diaphragm relationship: RO:0002380 UBERON:0000962 ! nerve of cervical vertebra -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001891 name: midbrain +def: "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]." [GO:0030901] +xref: AAO:0010149 +xref: BAMS:MES +xref: BIRNLEX:1667 +xref: BM:MB +xref: BTO:0000138 +xref: CALOHA:TS-0630 +xref: DHBA:10648 +xref: DMBA:16649 +xref: EFO:0000919 +xref: EHDAA2:0001162 +xref: EHDAA:3694 +xref: EMAPA:16974 +xref: EV:0100242 +xref: FMA:61993 +xref: HBA:9001 +xref: MA:0000207 +xref: MAT:0000106 +xref: MBA:313 +xref: MESH:D008636 +xref: MIAA:0000106 +xref: NCIT:C12510 +xref: RETIRED_EHDAA2:0001104 +xref: SCTID:279099009 +xref: TAO:0000128 +xref: VHOG:0000069 +xref: Wikipedia:Midbrain +xref: XAO:0000014 +xref: ZFA:0000128 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: RO:0002254 UBERON:0003849 ! mesencephalic neural crest relationship: RO:0002433 UBERON:0000955 ! brain relationship: RO:0002495 UBERON:0009616 ! presumptive midbrain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001892 name: rhombomere +def: "A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]." [Wikipedia:Rhombomere, ZFIN:curator] +xref: DHBA:12664 +xref: EFO:0003617 +xref: EMAPA:16148 +xref: FMA:295666 +xref: MAT:0000272 +xref: MIAA:0000272 +xref: RETIRED_EHDAA2:0000669 +xref: TAO:0001064 +xref: VHOG:0000672 +xref: Wikipedia:Rhombomere +xref: XAO:0004079 +xref: ZFA:0001064 is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: BFO:0000050 UBERON:0007277 ! part of presumptive hindbrain @@ -34408,6 +48772,24 @@ relationship: BFO:0000050 UBERON:0007277 ! part of presumptive hindbrain [Term] id: UBERON:0001895 name: metencephalon +def: "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Metencephalon] +comment: the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]. +xref: BAMS:Met +xref: BIRNLEX:965 +xref: BTO:0000673 +xref: CALOHA:TS-2029 +xref: DHBA:10655 +xref: EHDAA2:0001149 +xref: EHDAA:5498 +xref: EMAPA:17071 +xref: FMA:62003 +xref: GAID:594 +xref: HBA:4833 +xref: MA:0000197 +xref: MESH:D020540 +xref: NCIT:C32741 +xref: VHOG:0000741 +xref: Wikipedia:Metencephalon is_a: UBERON:0004733 ! segmental subdivision of hindbrain relationship: RO:0002433 UBERON:0002028 ! hindbrain relationship: RO:0002495 UBERON:0010092 ! future metencephalon @@ -34415,6 +48797,35 @@ relationship: RO:0002495 UBERON:0010092 ! future metencephalon [Term] id: UBERON:0001896 name: medulla oblongata +def: "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]." [FMA:62004, GO:0021550, Wikipedia:Bone_marrow_of_ovary_oblongata] +xref: AAO:0010486 +xref: BAMS:Md +xref: BAMS:MY +xref: BIRNLEX:957 +xref: BM:Me +xref: BTO:0000041 +xref: CALOHA:TS-0607 +xref: DMBA:17352 +xref: EFO:0000924 +xref: EHDAA2:0001088 +xref: EHDAA:7588 +xref: EMAPA:17550 +xref: EV:0100275 +xref: FMA:62004 +xref: GAID:590 +xref: MA:0000206 +xref: MAT:0000111 +xref: MAT:0000367 +xref: MBA:354 +xref: MESH:D008526 +xref: MIAA:0000111 +xref: NCIT:C12442 +xref: SCTID:279104005 +xref: TAO:0000545 +xref: VHOG:0000181 +xref: Wikipedia:Bone_marrow_of_ovary_oblongata +xref: XAO:0003100 +xref: ZFA:0000545 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0002298 ! part of brainstem @@ -34422,22 +48833,56 @@ relationship: BFO:0000050 UBERON:0005290 ! part of myelencephalon relationship: RO:0002215 GO:0002027 ! capable of regulation of heart rate relationship: RO:0002215 GO:0043576 ! capable of regulation of respiratory gaseous exchange relationship: RO:0002215 GO:0044058 ! capable of regulation of digestive system process -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001901 name: epithelium of trachea +def: "The epithelial lining of the trachea which contains numerous ciliated cells." [ISBN:0-397-51047-0, MGI:cwg, MP:0002285] +xref: BTO:0001389 +xref: CALOHA:TS-1061 +xref: EHDAA2:0002069 +xref: EHDAA:5007 +xref: EMAPA:16855 +xref: EMAPA:18409 +xref: FMA:62015 +xref: MA:0001862 +xref: NCIT:C33797 +xref: VHOG:0001045 is_a: UBERON:0008397 ! tracheobronchial epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 UBERON:0003258 ! endoderm of foregut relationship: RO:0002433 UBERON:0003126 ! trachea -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001902 +name: epithelium of small intestine +def: "An epithelium that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001258 +xref: CALOHA:TS-2104 +xref: EMAPA:35778 +xref: FMA:62017 +xref: MA:0001553 +xref: SCTID:45480009 +xref: TAO:0005127 +xref: ZFA:0005127 +is_a: UBERON:0001277 ! intestinal epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001204 ! part of mucosa of small intestine +relationship: BFO:0000051 CL:0000164 ! has part enteroendocrine cell [Term] id: UBERON:0001915 name: endothelium of capillary +def: "An endothelium that is part of a capillary [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004954 +xref: CALOHA:TS-0112 +xref: EMAPA:36292 +xref: FMA:62114 +xref: MA:0000711 +xref: NCIT:C49215 is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001982 ! part of capillary @@ -34446,6 +48891,11 @@ relationship: BFO:0000050 UBERON:0001982 ! part of capillary [Term] id: UBERON:0001916 name: endothelium of arteriole +def: "An endothelium that is part of an arteriole [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36286 +xref: FMA:62115 +xref: MA:0000705 +xref: NCIT:C49192 is_a: UBERON:0004700 ! arterial system endothelium is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium @@ -34455,6 +48905,15 @@ relationship: BFO:0000050 UBERON:0001980 ! part of arteriole [Term] id: UBERON:0001917 name: endothelium of artery +def: "An endothelium that is part of an artery [Automatically generated definition]." [OBOL:automatic] +xref: AAO:0011013 +xref: BTO:0004757 +xref: EMAPA:35148 +xref: FMA:62116 +xref: MA:0000707 +xref: NCIT:C49194 +xref: VHOG:0001215 +xref: XAO:0000357 is_a: UBERON:0003915 ! endothelial tube is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004700 ! arterial system endothelium @@ -34465,6 +48924,11 @@ relationship: BFO:0000050 UBERON:0001637 ! part of artery [Term] id: UBERON:0001918 name: endothelium of venule +def: "An endothelium that is part of a venule [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36290 +xref: FMA:62117 +xref: MA:0000716 +xref: NCIT:C49319 is_a: UBERON:0004701 ! venous system endothelium is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium @@ -34474,6 +48938,15 @@ relationship: BFO:0000050 UBERON:0001979 ! part of venule [Term] id: UBERON:0001919 name: endothelium of vein +def: "An endothelium that is part of a vein [Automatically generated definition]." [OBOL:automatic] +xref: AAO:0011110 +xref: BTO:0004756 +xref: EMAPA:36288 +xref: FMA:62118 +xref: MA:0000712 +xref: NCIT:C49317 +xref: VHOG:0001216 +xref: XAO:0000358 is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004701 ! venous system endothelium intersection_of: UBERON:0001986 ! endothelium @@ -34483,15 +48956,37 @@ relationship: BFO:0000050 UBERON:0001638 ! part of vein [Term] id: UBERON:0001943 name: midbrain tegmentum +def: "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]." [FMA:FMA, ISBN:0471888893, Wikipedia:Midbrain_tegmentum] +comment: 'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum +xref: BAMS:MTg +xref: BIRNLEX:1200 +xref: BTO:0003388 +xref: DHBA:12195 +xref: EFO:0000921 +xref: EHDAA2:0004475 +xref: EMAPA:18215 +xref: FMA:62393 +xref: HBA:9002 +xref: MA:0000212 +xref: MAT:0000452 +xref: SCTID:362392007 +xref: TAO:0000160 +xref: VHOG:0001367 +xref: Wikipedia:Midbrain_tegmentum +xref: XAO:0004271 +xref: ZFA:0000160 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: BFO:0000050 UBERON:0002298 ! part of brainstem relationship: RO:0002202 UBERON:0010285 ! midbrain basal plate -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001948 name: regional part of spinal cord +def: "A multi-tissue structure that is part of a spinal cord." [OBOL:automatic] +xref: BIRNLEX:1496 +xref: NCIT:C33969 +xref: SCTID:244437008 is_a: UBERON:0000073 ! regional part of nervous system is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000481 ! multi-tissue structure @@ -34501,15 +48996,25 @@ relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord [Term] id: UBERON:0001955 name: epithelium of respiratory bronchiole +def: "An epithelium that is part of a respiratory bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35730 +xref: FMA:62498 +xref: MA:0001773 +xref: NCIT:C48943 is_a: UBERON:0002051 ! epithelium of bronchiole intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole relationship: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001956 name: cartilage of bronchus +def: "The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]." [MP:0010988] +xref: EMAPA:35192 +xref: FMA:62649 +xref: MA:0001835 +xref: NCIT:C49209 +xref: SCTID:278980009 is_a: UBERON:0003603 ! lower respiratory tract cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus @@ -34517,11 +49022,16 @@ relationship: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000051 CL:0019002 ! has part tracheobronchial chondrocyte relationship: RO:0002433 UBERON:0002185 ! bronchus relationship: RO:0002473 UBERON:0001994 ! hyaline cartilage tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001957 name: submucosa of bronchus +def: "A submucosa that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0002108 +xref: FMA:62653 +xref: MA:0001837 +xref: NCIT:C49214 +xref: SCTID:85546005 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa @@ -34531,15 +49041,32 @@ relationship: BFO:0000050 UBERON:0002185 ! part of bronchus [Term] id: UBERON:0001958 name: terminal bronchiole epithelium +def: "An epithelium that lines a terminal bronchiole." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:36283 +xref: FMA:62794 +xref: MA:0001774 +xref: NCIT:C33755 is_a: UBERON:0002051 ! epithelium of bronchiole intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole relationship: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001969 name: blood plasma +def: "The liquid component of blood, in which erythrocytes are suspended." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000131 +xref: CALOHA:TS-0800 +xref: EFO:0001905 +xref: EMAPA:35690 +xref: FMA:62970 +xref: GAID:1178 +xref: MA:0002501 +xref: MAT:0000052 +xref: MESH:D010949 +xref: MIAA:0000052 +xref: NCIT:C13356 +xref: Wikipedia:Blood_plasma is_a: UBERON:0000179 ! haemolymphatic fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: BFO:0000050 UBERON:0000178 ! part of blood @@ -34550,9 +49077,43 @@ relationship: BFO:0000050 UBERON:0000178 ! part of blood relationship: BFO:0000051 GO:0005577 ! has part fibrinogen complex relationship: RO:0002221 CL:0000232 ! erythrocyte +[Term] +id: UBERON:0001970 +name: bile +def: "Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium." [DOI:10.1002/cphy.c120027, Wikipedia:Bile] +xref: BTO:0000121 +xref: CALOHA:TS-1172 +xref: ENVO:02000023 +xref: FMA:62971 +xref: GAID:1157 +xref: galen:Bile +xref: MA:0002513 +xref: MESH:D001646 +xref: NCIT:C13192 +xref: Wikipedia:Bile +xref: ZFA:0005857 +is_a: UBERON:0000456 ! secretion of exocrine gland +is_a: UBERON:0006314 ! bodily fluid +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: RO:0003001 UBERON:0002107 ! produced by liver +relationship: BFO:0000051 CHEBI:16990 ! has part +relationship: BFO:0000051 CHEBI:22868 ! has part +relationship: BFO:0000051 CHEBI:36277 ! has part +relationship: RO:0000086 PATO:0001735 +relationship: RO:0002216 GO:0007586 ! capable of part of digestion +relationship: RO:0003001 UBERON:0002107 ! produced by liver + [Term] id: UBERON:0001971 name: gastric juice +xref: BTO:0000501 +xref: FMA:62972 +xref: GAID:1160 +xref: galen:GastricJuice +xref: MA:0002519 +xref: MESH:D005750 +xref: NCIT:C32661 +xref: Wikipedia:Gastric_juice is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0011953 ! produced by stomach glandular region @@ -34561,6 +49122,12 @@ relationship: RO:0003001 UBERON:0011953 ! produced by stomach glandular region [Term] id: UBERON:0001972 name: submucosa of esophagus +def: "A submucosa that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0002109 +xref: EMAPA:35325 +xref: FMA:62997 +xref: MA:0002724 +xref: SCTID:362128009 is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -34569,6 +49136,11 @@ relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus [Term] id: UBERON:0001974 name: lamina propria of esophagus +def: "A lamina propria that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:26987 +xref: FMA:63050 +xref: MA:0001568 +xref: NCIT:C49223 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -34577,6 +49149,10 @@ relationship: BFO:0000050 UBERON:0002469 ! part of esophagus mucosa [Term] id: UBERON:0001975 name: serosa of esophagus +def: "A serous membrane that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35322 +xref: FMA:63057 +xref: MA:0001571 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -34585,6 +49161,17 @@ relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus [Term] id: UBERON:0001976 name: epithelium of esophagus +def: "The epithelial layer that lines the luminal space of the esophagus." [ISBN:0-683-40008-8, MP:0000468] +xref: BTO:0001578 +xref: CALOHA:TS-0698 +xref: EFO:0003041 +xref: EHDAA2:0001287 +xref: EMAPA:16835 +xref: FMA:63063 +xref: MA:0001565 +xref: NCIT:C49221 +xref: TAO:0001499 +xref: ZFA:0001499 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium @@ -34592,18 +49179,55 @@ intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0002469 ! part of esophagus mucosa relationship: RO:0002433 UBERON:0001043 ! esophagus +[Term] +id: UBERON:0001978 +name: parenchyma of pancreas +xref: EMAPA:32925 +xref: FMA:63120 +xref: MA:0000724 +xref: SCTID:371401008 +xref: VHOG:0001430 +is_a: UBERON:0000353 ! parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: UBERON:0001979 name: venule +def: "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins." [MESH:A07.231.432.952, MP:0004125] +xref: BTO:0002626 +xref: EMAPA:35917 +xref: FMA:63130 +xref: MA:0000071 +xref: MESH:D014699 +xref: NCIT:C12818 +xref: SCTID:341687009 +xref: TAO:0005315 +xref: VHOG:0001765 +xref: Wikipedia:Venule +xref: ZFA:0005315 is_a: UBERON:0003920 ! venous blood vessel is_a: UBERON:8410081 ! blood microvessel relationship: RO:0002176 UBERON:0001638 ! vein relationship: RO:0002176 UBERON:0001982 ! capillary -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001980 name: arteriole +def: "The smallest division of the artery located between the muscular arteries and the capillaries[GO]." [GO:0014830] +xref: AAO:0010253 +xref: BTO:0001997 +xref: EMAPA:35146 +xref: FMA:63182 +xref: MA:0000063 +xref: MESH:D001160 +xref: NCIT:C12672 +xref: SCTID:337724002 +xref: TAO:0002138 +xref: VHOG:0001763 +xref: Wikipedia:Arteriole +xref: ZFA:0005255 is_a: UBERON:0003509 ! arterial blood vessel is_a: UBERON:8410081 ! blood microvessel intersection_of: UBERON:0001981 ! blood vessel @@ -34616,6 +49240,30 @@ relationship: RO:0002433 UBERON:0001637 ! artery [Term] id: UBERON:0001981 name: blood vessel +def: "A vessel through which blood circulates in the body." [BTO:0001102, Wikipedia:Blood_vessel] +xref: AAO:0011004 +xref: AEO:0000207 +xref: BTO:0001102 +xref: CALOHA:TS-0080 +xref: EFO:0000817 +xref: EHDAA2:0003252 +xref: EHDAA:240 +xref: EMAPA:32743 +xref: EMAPA:35993 +xref: FMA:50722 +xref: FMA:63183 +xref: GAID:169 +xref: MA:0000060 +xref: MAT:0000393 +xref: MESH:D001808 +xref: NCIT:C12679 +xref: NLXANAT:090901 +xref: SCTID:361097006 +xref: TAO:0002137 +xref: VHOG:0001250 +xref: Wikipedia:Blood_vessel +xref: XAO:0001011 +xref: ZFA:0005314 is_a: UBERON:0000055 ! vessel is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0004537 ! part of blood vasculature @@ -34626,22 +49274,49 @@ relationship: RO:0000086 PATO:0002045 relationship: RO:0002202 UBERON:0004872 ! splanchnic layer of lateral plate mesoderm relationship: RO:0002202 UBERON:0006965 ! vascular cord relationship: RO:0002216 GO:0008015 ! capable of part of blood circulation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001982 name: capillary +def: "Any of the smallest blood vessels connecting arterioles with venules." [https://github.com/obophenotype/uberon/issues/137, ISBN:0073040584, Wikipedia:Capillary] +xref: AAO:0010252 +xref: BTO:0002045 +xref: CALOHA:TS-2006 +xref: EFO:0001906 +xref: EMAPA:35198 +xref: EV:0100035 +xref: FMA:63194 +xref: MA:0000065 +xref: MESH:D002196 +xref: NCIT:C12685 +xref: NLXANAT:090902 +xref: TAO:0005250 +xref: VHOG:0001253 +xref: Wikipedia:Capillary +xref: XAO:0000116 +xref: ZFA:0005250 is_a: UBERON:8410081 ! blood microvessel intersection_of: UBERON:8410081 ! blood microvessel intersection_of: RO:0002176 UBERON:0001979 ! venule intersection_of: RO:0002176 UBERON:0001980 ! arteriole relationship: RO:0002176 UBERON:0001979 ! venule relationship: RO:0002176 UBERON:0001980 ! arteriole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001985 name: corneal endothelium +def: "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]." [Wikipedia:Corneal_endothelium] +xref: CALOHA:TS-0172 +xref: EMAPA:35935 +xref: FMA:63882 +xref: GAID:891 +xref: MA:0001242 +xref: MESH:D004728 +xref: NCIT:C12707 +xref: SCTID:368827009 +xref: TAO:0002186 +xref: Wikipedia:Corneal_endothelium +xref: ZFA:0001687 is_a: UBERON:0001986 ! endothelium is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0015808 ! eye epithelium @@ -34650,28 +49325,85 @@ intersection_of: BFO:0000050 UBERON:0000964 ! part of cornea relationship: BFO:0000050 UBERON:0000964 ! part of cornea relationship: RO:0002220 UBERON:0001766 ! adjacent to anterior chamber of eyeball relationship: RO:0002433 UBERON:0000964 ! cornea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001986 name: endothelium +def: "A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]." [FMA:63916, https://github.com/obophenotype/uberon/issues/225, MESH:A10.272.491] +comment: The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980) +xref: BTO:0000393 +xref: CALOHA:TS-0278 +xref: EFO:0002548 +xref: FMA:63916 +xref: GAID:520 +xref: galen:Endothelium +xref: MESH:D004727 +xref: NCIT:C12481 +xref: SCTID:27168002 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002473 CL:0000115 ! endothelial cell relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002473 CL:0000115 ! endothelial cell -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001988 +name: feces +def: "Portion of semisolid bodily waste discharged through the anus[MW,modified]." [http://www.merriam-webster.com/dictionary/feces, Wikipedia:Feces] +xref: BTO:0000440 +xref: CALOHA:TS-2345 +xref: ENVO:00002003 +xref: FMA:64183 +xref: GAID:1199 +xref: galen:Feces +xref: MA:0002509 +xref: MAT:0000053 +xref: MESH:D005243 +xref: MIAA:0000053 +xref: NCIT:C13234 +xref: Wikipedia:Feces +is_a: UBERON:0000174 ! excreta +intersection_of: UBERON:0000174 ! excreta +intersection_of: RO:0002353 GO:0030421 ! output of defecation +relationship: RO:0002353 GO:0030421 ! output of defecation [Term] id: UBERON:0001994 name: hyaline cartilage tissue +def: "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000094] +xref: EMAPA:35414 +xref: FMA:64783 +xref: MA:0000109 +xref: NCIT:C32746 +xref: SCTID:39298000 +xref: VSAO:0000094 +xref: Wikipedia:Hyaline_cartilage +xref: XAO:0004029 is_a: UBERON:0002418 ! cartilage tissue relationship: RO:0002473 GO:0005585 ! collagen type II trimer [Term] id: UBERON:0002012 name: pulmonary artery +def: "An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Pulmonary_artery] +xref: AAO:0010221 +xref: BTO:0000778 +xref: CALOHA:TS-0839 +xref: EFO:0001399 +xref: EHDAA2:0001575 +xref: EHDAA:4351 +xref: EMAPA:17008 +xref: FMA:66326 +xref: GAID:505 +xref: galen:PulmonaryArtery +xref: MA:0002031 +xref: MESH:D011651 +xref: NCIT:C12774 +xref: SCTID:181380003 +xref: VHOG:0000982 +xref: Wikipedia:Pulmonary_artery +xref: XAO:0004162 is_a: UBERON:0001637 ! artery is_a: UBERON:0013768 ! great vessel of heart intersection_of: UBERON:0001637 ! artery @@ -34684,11 +49416,27 @@ relationship: RO:0002178 UBERON:0002048 ! lung relationship: RO:0002202 UBERON:0002061 ! truncus arteriosus relationship: RO:0002202 UBERON:0003123 ! pharyngeal arch artery 6 relationship: RO:0002202 UBERON:0005339 ! outflow tract pulmonary component -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002016 name: pulmonary vein +def: "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]." [GO:0060577] +xref: AAO:0010521 +xref: BTO:0001799 +xref: CALOHA:TS-0840 +xref: EHDAA2:0001579 +xref: EHDAA:2629 +xref: EMAPA:18645 +xref: FMA:66643 +xref: GAID:543 +xref: galen:PulmonaryVein +xref: MA:0002206 +xref: MESH:D011667 +xref: NCIT:C12776 +xref: SCTID:430160002 +xref: VHOG:0001133 +xref: Wikipedia:Pulmonary_vein +xref: XAO:0000394 is_a: UBERON:0001638 ! vein is_a: UBERON:0013768 ! great vessel of heart intersection_of: UBERON:0001638 ! vein @@ -34697,27 +49445,111 @@ relationship: BFO:0000050 UBERON:0008886 ! part of pulmonary vascular system relationship: RO:0002170 UBERON:0002079 ! left cardiac atrium relationship: RO:0002179 UBERON:0002048 ! lung relationship: RO:0002202 UBERON:0002061 ! truncus arteriosus -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002017 +name: portal vein +def: "A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]." [BTO:0001792] +xref: BTO:0001792 +xref: CALOHA:TS-0814 +xref: EHDAA2:0001485 +xref: EHDAA:6510 +xref: EMAPA:17349 +xref: FMA:66645 +xref: GAID:540 +xref: galen:PortalVein +xref: MA:0002198 +xref: MESH:D011169 +xref: NCIT:C33343 +xref: SCTID:362064007 +xref: VHOG:0000656 +xref: XAO:0000392 +is_a: UBERON:0001638 ! vein +relationship: BFO:0000050 UBERON:0005806 ! part of portal system [Term] id: UBERON:0002020 name: gray matter +def: "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Gray_matter] +xref: AEO:0001012 +xref: EHDAA2:0003136 +xref: EHDAA2_RETIRED:0004658 +xref: FMA:67242 +xref: HBA:4006 +xref: MA:0001112 +xref: NCIT:C32695 +xref: neuronames:2869 +xref: TAO:0002197 +xref: VHOG:0001768 +xref: Wikipedia:Gray_matter +xref: ZFA:0001681 is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: RO:0002473 GO:0043025 ! neuronal cell body [Term] id: UBERON:0002028 name: hindbrain +def: "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]." [Wikipedia:Rhombencephalon, ZFA:0000029, ZFIN:curator] +xref: AAO:0010150 +xref: BAMS:HB +xref: BIRNLEX:942 +xref: BTO:0000672 +xref: CALOHA:TS-0457 +xref: DHBA:10653 +xref: DMBA:16808 +xref: EFO:0000923 +xref: EHDAA2:0000746 +xref: EHDAA:3514 +xref: EHDAA:6487 +xref: EMAPA:16916 +xref: FMA:67687 +xref: MA:0000195 +xref: MAT:0000107 +xref: MBA:1065 +xref: MESH:D012249 +xref: MIAA:0000107 +xref: NCIT:C40336 +xref: SCTID:303456008 +xref: TAO:0000029 +xref: VHOG:0000070 +xref: Wikipedia:Rhombencephalon +xref: XAO:0000015 +xref: ZFA:0000029 is_a: UBERON:0002616 ! regional part of brain relationship: RO:0002131 UBERON:0002298 ! overlaps brainstem relationship: RO:0002160 NCBITaxon:89593 ! Craniata relationship: RO:0002433 UBERON:0000955 ! brain relationship: RO:0002495 UBERON:0007277 ! presumptive hindbrain -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002029 +name: epithelium of gall bladder +def: "The simple columnar epithelial lining of the gall bladder." [MP:0009492] +xref: BTO:0001449 +xref: CALOHA:TS-1304 +xref: EMAPA:35370 +xref: FMA:67711 +xref: MA:0001632 +xref: NCIT:C49227 +is_a: UBERON:0000485 ! simple columnar epithelium +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0034932 ! epithelium of biliary system +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: RO:0002433 UBERON:0002110 ! gallbladder [Term] id: UBERON:0002031 name: epithelium of bronchus +def: "An epithelium that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001845 +xref: CALOHA:TS-1240 +xref: EFO:0000307 +xref: EMAPA:32691 +xref: FMA:67782 +xref: MA:0001839 +xref: NCIT:C32231 is_a: UBERON:0008397 ! tracheobronchial epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus @@ -34728,6 +49560,18 @@ relationship: RO:0002433 UBERON:0002185 ! bronchus [Term] id: UBERON:0002036 name: striated muscle tissue +def: "Muscle tissue that contains fibers that are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_muscle] +xref: AAO:0010762 +xref: AEO:0000140 +xref: CALOHA:TS-2047 +xref: EHDAA2:0003140 +xref: EMAPA:36390 +xref: FMA:67905 +xref: galen:StriatedMuscle +xref: MA:0002438 +xref: NCIT:C12436 +xref: WBbt:0005779 +xref: Wikipedia:Striated_muscle is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: RO:0002473 CL:0000737 ! striated muscle cell @@ -34736,6 +49580,16 @@ relationship: RO:0002473 CL:0000737 ! striated muscle cell [Term] id: UBERON:0002040 name: bronchial artery +def: "A systemic artery that supplies the lung with with oxygenated blood." [UBERON:cjm, Wikipedia:Bronchial_artery] +comment: Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung. +xref: EMAPA:18608 +xref: FMA:68109 +xref: GAID:477 +xref: MA:0001923 +xref: MESH:D001981 +xref: NCIT:C32230 +xref: SCTID:244247009 +xref: Wikipedia:Bronchial_artery is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0004573 ! systemic artery intersection_of: BFO:0000050 UBERON:0004571 ! part of systemic arterial system @@ -34743,11 +49597,22 @@ intersection_of: RO:0002178 UBERON:0002048 ! lung relationship: BFO:0000051 UBERON:0004848 ! has part respiratory system arterial endothelium relationship: BFO:0000051 UBERON:0012416 ! has part respiratory system arterial smooth muscle relationship: RO:0002178 UBERON:0002048 ! lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002047 name: pontine raphe nucleus +def: "The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]." [Wikipedia:Pontine_raphe_nucleus] +xref: BAMS:PnR +xref: BAMS:RA-PONS +xref: BAMS:RPn +xref: BIRNLEX:1110 +xref: DHBA:12471 +xref: DHBA:12475 +xref: FMA:68875 +xref: HBA:9159 +xref: MA:0001022 +xref: MBA:238 +xref: Wikipedia:Pontine_raphe_nucleus is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus relationship: BFO:0000050 UBERON:0003023 ! part of pontine tegmentum @@ -34756,6 +49621,29 @@ relationship: BFO:0000050 UBERON:0004684 ! part of raphe nuclei [Term] id: UBERON:0002048 name: lung +def: "Respiration organ that develops as an outpocketing of the esophagus." [http://orcid.org/0000-0002-6601-2165] +comment: Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP] +xref: AAO:0000275 +xref: AAO:0010567 +xref: BTO:0000763 +xref: CALOHA:TS-0568 +xref: EFO:0000934 +xref: EHDAA2:0001042 +xref: EHDAA:1554 +xref: EHDAA:2205 +xref: EMAPA:16728 +xref: EV:0100042 +xref: FMA:7195 +xref: GAID:345 +xref: galen:Lung +xref: MA:0000415 +xref: MAT:0000135 +xref: MESH:D008168 +xref: MIAA:0000135 +xref: NCIT:C12468 +xref: SCTID:181216001 +xref: Wikipedia:Lung +xref: XAO:0000119 is_a: UBERON:0000171 ! respiration organ is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005178 ! thoracic cavity element @@ -34765,20 +49653,39 @@ relationship: BSPO:0000126 UBERON:0000170 ! pair of lungs relationship: RO:0002160 NCBITaxon:7776 ! Gnathostomata relationship: RO:0002202 UBERON:0000118 ! lung bud relationship: RO:0002433 UBERON:0001004 ! respiratory system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002049 name: vasculature +def: "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face." [ZFA:0005249] +xref: BTO:0003718 +xref: FMA:69050 +xref: TAO:0005249 +xref: ZFA:0005249 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0007798 ! part of vascular system relationship: BFO:0000051 UBERON:0000179 ! has part haemolymphatic fluid relationship: RO:0002473 UBERON:0000055 ! vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002050 name: embryonic structure +def: "Anatomical structure that is part of an embryo." [BTO:0000174, ZFIN:curator] +xref: AAO:0000138 +xref: BILA:0000034 +xref: BTO:0000174 +xref: CALOHA:TS-2110 +xref: EFO:0000461 +xref: FMA:69067 +xref: GAID:407 +xref: MESH:D004628 +xref: NCIT:C13229 +xref: RETIRED_EHDAA2:0003169 +xref: SCTID:667009 +xref: TAO:0001105 +xref: VSAO:0000178 +xref: XAO:0003042 +xref: ZFA:0001105 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -34787,6 +49694,13 @@ relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: UBERON:0002051 name: epithelium of bronchiole +def: "An epithelium that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001866 +xref: CALOHA:TS-0570 +xref: EMAPA:32693 +xref: FMA:69077 +xref: MA:0001772 +xref: NCIT:C48942 is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0008397 ! tracheobronchial epithelium @@ -34797,11 +49711,14 @@ relationship: BFO:0000051 CL:0000158 ! has part club cell relationship: BFO:0000051 CL:0002145 ! has part ciliated columnar cell of tracheobronchial tree relationship: BFO:0000051 CL:1000271 ! has part lung ciliated cell relationship: RO:0002433 UBERON:0002186 ! bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002057 name: phrenic artery +def: "An artery that supplies the diaphragm." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:69330 +xref: MA:0002019 +xref: NCIT:C33320 is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0004573 ! systemic artery intersection_of: RO:0002178 UBERON:0001103 ! diaphragm @@ -34810,6 +49727,16 @@ relationship: RO:0002178 UBERON:0001103 ! diaphragm [Term] id: UBERON:0002061 name: truncus arteriosus +def: "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles." [Wikipedia:Truncus_arteriosus_(embryology)] +xref: EHDAA2:0004143 +xref: EMAPA:35887 +xref: FMA:70301 +xref: GAID:554 +xref: MA:0000103 +xref: MESH:D014338 +xref: NCIT:C34317 +xref: SCTID:308828009 +xref: Wikipedia:Truncus_arteriosus_(embryology) is_a: UBERON:0001637 ! artery is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003498 ! heart blood vessel @@ -34820,6 +49747,19 @@ relationship: RO:0002202 UBERON:0005432 ! aortic sac [Term] id: UBERON:0002062 name: endocardial cushion +def: "The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]." [GO:0003197, Wikipedia:Atrioventricular_cushions, ZFIN:curator] +comment: GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form +xref: EHDAA2:0000434 +xref: EHDAA2:0004028 +xref: EHDAA:2586 +xref: EMAPA:16696 +xref: FMA:70302 +xref: MA:0000078 +xref: TAO:0001317 +xref: VHOG:0000932 +xref: Wikipedia:Atrioventricular_cushions +xref: XAO:0004189 +xref: ZFA:0001317 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0009751 ! cardiac mesenchyme @@ -34829,6 +49769,18 @@ relationship: BFO:0000050 UBERON:0002165 ! part of endocardium [Term] id: UBERON:0002063 name: sinus venosus +def: "The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart." [PMID:20735616, Wikipedia:Sinus_venosus] +xref: AAO:0010505 +xref: EHDAA2:0001839 +xref: EHDAA:480 +xref: EMAPA:16237 +xref: FMA:70303 +xref: NCIT:C34299 +xref: NCIT:C34300 +xref: TAO:0000154 +xref: VHOG:0000177 +xref: Wikipedia:Sinus_venosus +xref: ZFA:0000154 is_a: UBERON:0004151 ! cardiac chamber relationship: BFO:0000050 UBERON:0002350 ! part of conducting system of heart relationship: RO:0002495 UBERON:0007278 ! presumptive sinus venosus @@ -34836,6 +49788,26 @@ relationship: RO:0002495 UBERON:0007278 ! presumptive sinus venosus [Term] id: UBERON:0002067 name: dermis +def: "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." [Wikipedia:Dermis, ZFIN:curator] +xref: AAO:0000128 +xref: BTO:0000294 +xref: CALOHA:TS-2076 +xref: EFO:0000953 +xref: EMAPA:17527 +xref: EV:0100154 +xref: FMA:70323 +xref: GAID:1321 +xref: MA:0000152 +xref: MAT:0000153 +xref: MESH:D020405 +xref: MIAA:0000153 +xref: NCIT:C12701 +xref: SCTID:361696001 +xref: TAO:0001119 +xref: VHOG:0000108 +xref: Wikipedia:Dermis +xref: XAO:0000217 +xref: ZFA:0001119 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013754 ! integumentary system layer @@ -34846,11 +49818,18 @@ relationship: BSPO:0000107 UBERON:0001003 ! skin epidermis relationship: BSPO:0000108 UBERON:0002072 ! hypodermis relationship: RO:0002473 UBERON:0002384 ! connective tissue relationship: RO:0002495 UBERON:0010083 ! future dermis -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002072 name: hypodermis +def: "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." [Wikipedia:Hypodermis] +xref: BTO:0001314 +xref: CALOHA:TS-2366 +xref: FMA:70544 +xref: NCIT:C33645 +xref: TAO:0001136 +xref: Wikipedia:Hypodermis +xref: ZFA:0001136 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013754 ! integumentary system layer relationship: BFO:0000050 UBERON:0002199 ! part of integument @@ -34858,11 +49837,23 @@ relationship: BSPO:0000107 UBERON:0002067 ! dermis relationship: BSPO:0000108 UBERON:0001015 ! musculature relationship: RO:0002473 UBERON:0001013 ! adipose tissue relationship: RO:0002473 UBERON:0011825 ! loose connective tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002075 name: viscus +def: "An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen." [BTO:0001491, https://github.com/obophenotype/mouse-anatomy-ontology/issues/14, Wikipedia:Viscus] +xref: AAO:0010386 +xref: BTO:0001491 +xref: EHDAA:512 +xref: EMAPA:16245 +xref: FMA:7085 +xref: MA:0000019 +xref: MESH:D014781 +xref: NCIT:C28287 +xref: RETIRED_EHDAA2:0002201 +xref: SCTID:118760003 +xref: Wikipedia:Viscus +xref: XAO:0003034 is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0000062 ! organ intersection_of: RO:0001025 UBERON:0002323 ! coelemic cavity lumen @@ -34871,26 +49862,62 @@ relationship: RO:0001025 UBERON:0002323 ! coelemic cavity lumen [Term] id: UBERON:0002078 name: right cardiac atrium +def: "A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Right_atrium] +xref: AAO:0010248 +xref: BTO:0001703 +xref: EHDAA2:0000290 +xref: EMAPA:17321 +xref: FMA:7096 +xref: galen:RightAtrium +xref: MA:0000075 +xref: NCIT:C12868 +xref: SCTID:244383003 +xref: VHOG:0000328 +xref: Wikipedia:Right_atrium +xref: XAO:0003192 is_a: UBERON:0002081 ! cardiac atrium is_a: UBERON:0035554 ! right cardiac chamber intersection_of: UBERON:0002081 ! cardiac atrium intersection_of: BSPO:0000121 UBERON:0000948 ! heart relationship: RO:0002170 UBERON:0004537 ! blood vasculature -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002079 name: left cardiac atrium +def: "A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Left_atrium] +xref: AAO:0010247 +xref: BTO:0001702 +xref: EHDAA2:0000275 +xref: EMAPA:17315 +xref: FMA:7097 +xref: galen:LeftAtrium +xref: MA:0000074 +xref: NCIT:C12869 +xref: SCTID:244387002 +xref: VHOG:0000369 +xref: Wikipedia:Left_atrium +xref: XAO:0003191 is_a: UBERON:0002081 ! cardiac atrium is_a: UBERON:0035553 ! left cardiac chamber intersection_of: UBERON:0002081 ! cardiac atrium intersection_of: BSPO:0000120 UBERON:0000948 ! heart relationship: RO:0002170 UBERON:0004537 ! blood vasculature -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002080 name: heart right ventricle +def: "A cardiac ventricle that is in the right side of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0001630 +xref: CALOHA:TS-0443 +xref: EHDAA2:0000196 +xref: EMAPA:17340 +xref: FMA:7098 +xref: galen:RightVentricle +xref: MA:0000093 +xref: NCIT:C12870 +xref: SCTID:244384009 +xref: VHOG:0000717 +xref: Wikipedia:Right_ventricle is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035554 ! right cardiac chamber intersection_of: UBERON:0002082 ! cardiac ventricle @@ -34898,11 +49925,31 @@ intersection_of: BSPO:0000121 UBERON:0000948 ! heart relationship: RO:0002170 UBERON:0004537 ! blood vasculature relationship: RO:0002202 UBERON:0009889 ! secondary heart field relationship: RO:0002254 UBERON:0004706 ! bulbus cordis -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002081 name: cardiac atrium +def: "Cardiac chamber in which blood enters the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Heart_atrium] +xref: AAO:0010246 +xref: BTO:0000903 +xref: CALOHA:TS-0437 +xref: EFO:0000277 +xref: EHDAA2:0000154 +xref: EHDAA:1265 +xref: EMAPA:16688 +xref: EV:0100019 +xref: FMA:7099 +xref: GAID:555 +xref: galen:Atrium +xref: MA:0000073 +xref: MAT:0000496 +xref: MESH:D006325 +xref: NCIT:C12728 +xref: SCTID:261405004 +xref: TAO:0000471 +xref: VHOG:0000175 +xref: Wikipedia:Heart_atrium +xref: ZFA:0000471 is_a: UBERON:0004151 ! cardiac chamber relationship: RO:0002433 UBERON:0000948 ! heart relationship: RO:0002495 UBERON:0010227 ! future cardiac atrium @@ -34910,6 +49957,28 @@ relationship: RO:0002495 UBERON:0010227 ! future cardiac atrium [Term] id: UBERON:0002082 name: cardiac ventricle +def: "Cardiac chamber through which blood leaves the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Ventricle_(heart)] +xref: AAO:0010249 +xref: BTO:0000862 +xref: CALOHA:TS-0444 +xref: EFO:0000317 +xref: EHDAA2:0004164 +xref: EHDAA:1912 +xref: EMAPA:17331 +xref: EV:0100020 +xref: FMA:7100 +xref: GAID:568 +xref: galen:Ventricle +xref: MA:0000091 +xref: MAT:0000497 +xref: MESH:D006352 +xref: NCIT:C12730 +xref: SCTID:277699000 +xref: TAO:0000009 +xref: VHOG:0000435 +xref: Wikipedia:Ventricle_(heart) +xref: XAO:0003193 +xref: ZFA:0000009 is_a: UBERON:0004151 ! cardiac chamber relationship: RO:0002433 UBERON:0000948 ! heart relationship: RO:0002495 UBERON:0006283 ! future cardiac ventricle @@ -34917,6 +49986,18 @@ relationship: RO:0002495 UBERON:0006283 ! future cardiac ventricle [Term] id: UBERON:0002084 name: heart left ventricle +def: "A cardiac ventricle that is in the left side of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0001629 +xref: CALOHA:TS-0439 +xref: EHDAA2:0002178 +xref: EMAPA:17337 +xref: FMA:7101 +xref: galen:LeftVentricle +xref: MA:0000092 +xref: NCIT:C12871 +xref: SCTID:244385005 +xref: VHOG:0000718 +xref: Wikipedia:Left_ventricle is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035553 ! left cardiac chamber intersection_of: UBERON:0002082 ! cardiac ventricle @@ -34924,11 +50005,21 @@ intersection_of: BSPO:0000120 UBERON:0000948 ! heart relationship: RO:0002150 UBERON:0000947 ! aorta relationship: RO:0002170 UBERON:0004537 ! blood vasculature relationship: RO:0002202 UBERON:0004140 ! primary heart field -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002085 name: interatrial septum +def: "A cardiac septum that divides the left and right atria of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0000838 +xref: EHDAA:1896 +xref: EMAPA:17011 +xref: FMA:7108 +xref: galen:InteratrialSeptum +xref: MA:0000084 +xref: NCIT:C32818 +xref: SCTID:362016003 +xref: VHOG:0000385 +xref: Wikipedia:Interatrial_septum is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: RO:0002220 UBERON:0002078 ! adjacent to right cardiac atrium @@ -34939,6 +50030,21 @@ relationship: RO:0002220 UBERON:0002079 ! adjacent to left cardiac atrium [Term] id: UBERON:0002090 name: postcranial axial skeleton +def: "The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]." [https://sourceforge.net/tracker/?func=detail&aid=2983975&group_id=76834&atid=974957, https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=2983977&group_id=76834, ZFA:0000317] +comment: previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed. +xref: AAO:0000034 +xref: EFO:0000942 +xref: EHDAA2:0000161 +xref: EHDAA:5049 +xref: FMA:71221 +xref: MA:0002986 +xref: MAT:0000148 +xref: MIAA:0000148 +xref: TAO:0000317 +xref: VHOG:0000317 +xref: VSAO:0000093 +xref: XAO:0003073 +xref: ZFA:0000317 is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0005944 ! part of axial skeleton plus cranial skeleton relationship: BFO:0000050 UBERON:0011138 ! part of postcranial axial skeletal system @@ -34947,37 +50053,98 @@ relationship: RO:0002202 UBERON:0003089 ! sclerotome [Term] id: UBERON:0002091 name: appendicular skeleton +def: "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003, Wikipedia:Appendicular_skeleton] +xref: AAO:0000747 +xref: EFO:0000951 +xref: EMAPA:32729 +xref: FMA:71222 +xref: MA:0000290 +xref: MAT:0000278 +xref: MIAA:0000278 +xref: NCIT:C49477 +xref: SCTID:322050006 +xref: VSAO:0000076 +xref: Wikipedia:Appendicular_skeleton +xref: XAO:0003166 is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0011249 ! part of appendicular skeletal system relationship: RO:0002131 UBERON:0000026 ! overlaps appendage relationship: RO:0002160 NCBITaxon:7776 ! Gnathostomata relationship: RO:0002433 UBERON:0001434 ! skeletal system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002094 name: interventricular septum +def: "Cardiac septum which separates the right ventricle from the left ventricle.[FMA]." [FMA:7133] +xref: BTO:0002483 +xref: EFO:0001956 +xref: EHDAA:2603 +xref: EMAPA:17333 +xref: FMA:7133 +xref: galen:InterventricularSeptum +xref: MA:0000085 +xref: NCIT:C32874 +xref: SCTID:362019005 +xref: VHOG:0000386 +xref: Wikipedia:Interventricular_septum is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: RO:0002220 UBERON:0002080 ! adjacent to heart right ventricle intersection_of: RO:0002220 UBERON:0002084 ! adjacent to heart left ventricle relationship: RO:0002220 UBERON:0002080 ! adjacent to heart right ventricle relationship: RO:0002220 UBERON:0002084 ! adjacent to heart left ventricle -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002095 +name: mesentery +def: "Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon." [FMA:7144, https://github.com/obophenotype/uberon/issues/85, Wikipedia:Mesentery, Wikipedia:Mesentery#Mesentery_.28general.29] +xref: AAO:0011061 +xref: BTO:0001380 +xref: EV:0100083 +xref: FMA:7144 +xref: GAID:21 +xref: galen:Mesentery +xref: MESH:D008643 +xref: NCIT:C33103 +xref: SCTID:362707009 +xref: Wikipedia:Mesentery#Mesentery_.28general.29 +is_a: UBERON:0000042 ! serous membrane +relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0002097 name: skin of body +def: "The organ covering the body that consists of the dermis and epidermis." [UBERON:cjm] +xref: BTO:0001253 +xref: CALOHA:TS-0934 +xref: EFO:0000962 +xref: EHDAA2:0001844 +xref: EMAPA:17525 +xref: FMA:7163 +xref: galen:Skin +xref: MESH:D012867 +xref: MFMO:0000099 +xref: NCIT:C12470 +xref: SCTID:181469002 +xref: Wikipedia:Skin +xref: XAO:0000023 is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0002199 ! part of integument relationship: RO:0002202 UBERON:0011272 ! embryonic skin basal layer relationship: RO:0002473 UBERON:0000014 ! zone of skin -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002099 name: cardiac septum +def: "The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles." [MESH:A07.541.459] +xref: EMAPA:35400 +xref: FMA:7180 +xref: GAID:562 +xref: MA:0000083 +xref: MESH:D006346 +xref: NCIT:C49485 +xref: SCTID:362014000 is_a: UBERON:0003037 ! septum is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003037 ! septum @@ -34989,6 +50156,25 @@ relationship: RO:0002433 UBERON:0000948 ! heart [Term] id: UBERON:0002100 name: trunk +def: "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present." [TAO:0001115, UBERONREF:0000006, Wikipedia:Torso] +xref: AAO:0010339 +xref: BILA:0000116 +xref: BTO:0001493 +xref: CALOHA:TS-1071 +xref: EFO:0000966 +xref: EMAPA:31857 +xref: FMA:7181 +xref: galen:Trunk +xref: MA:0000004 +xref: MAT:0000296 +xref: MIAA:0000296 +xref: NCIT:C33816 +xref: SCTID:262225004 +xref: TAO:0001115 +xref: Wikipedia:Torso +xref: XAO:0000054 +xref: XAO:0003025 +xref: ZFA:0001115 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: BFO:0000050 UBERON:0013702 ! part of body proper relationship: BFO:0000051 UBERON:0000915 {gci_filler="NCBITaxon:7742", gci_relation="BFO:0000050"} ! has part thoracic segment of trunk @@ -34997,18 +50183,181 @@ relationship: BFO:0000051 UBERON:0000916 {gci_filler="NCBITaxon:7742", gci_relat [Term] id: UBERON:0002104 name: visual system +def: "The sensory system subserving the sense of vision." [NIFSTD:FMAID_7191] +xref: AAO:0000632 +xref: BILA:0000140 +xref: EMAPA:36003 +xref: FMA:7191 +xref: http://uri.neuinfo.org/nif/nifstd/FMAID_7191 +xref: MA:0002444 +xref: NCIT:C12888 +xref: SCTID:281831001 +xref: TAO:0001127 +xref: Wikipedia:Visual_system +xref: XAO:0003198 +xref: ZFA:0001127 is_a: UBERON:0001032 ! sensory system relationship: RO:0002216 GO:0007601 ! capable of part of visual perception [Term] id: UBERON:0002105 name: vestibulo-auditory system +def: "Sensory system responsible for the perception of spatial orientation and auditory stimuli." [ZFA:0001138] +xref: AAO:0000631 +xref: FMA:78500 +xref: TAO:0001138 +xref: XAO:0003195 +xref: ZFA:0001138 is_a: UBERON:0001032 ! sensory system relationship: RO:0002216 GO:0007605 ! capable of part of sensory perception of sound +[Term] +id: UBERON:0002106 +name: spleen +def: "The organ that functions to filter blood and to store red corpuscles and platelets." [ISBN:0-683-40008-8, MP:0000689] +xref: AAO:0010395 +xref: BTO:0001281 +xref: CALOHA:TS-0956 +xref: EFO:0000869 +xref: EMAPA:18767 +xref: EV:0100055 +xref: FMA:7196 +xref: GAID:1289 +xref: galen:Spleen +xref: MA:0000141 +xref: MAT:0000085 +xref: MESH:D013154 +xref: MIAA:0000085 +xref: NCIT:C12432 +xref: SCTID:181279003 +xref: TAO:0000436 +xref: VHOG:0000120 +xref: Wikipedia:Spleen +xref: XAO:0000328 +xref: ZFA:0000436 +is_a: UBERON:0004177 ! hemopoietic organ +is_a: UBERON:0005057 ! immune organ +is_a: UBERON:0017672 ! abdominal viscera +relationship: RO:0002160 NCBITaxon:7776 ! Gnathostomata +relationship: RO:0002202 UBERON:0006293 ! spleen primordium + +[Term] +id: UBERON:0002107 +name: liver +def: "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." [BTO:0000759, Wikipedia:Liver] +xref: AAO:0010111 +xref: BTO:0000759 +xref: CALOHA:TS-0564 +xref: EFO:0000887 +xref: EHDAA2:0000997 +xref: EHDAA:2197 +xref: EMAPA:16846 +xref: EV:0100089 +xref: FMA:7197 +xref: GAID:288 +xref: galen:Liver +xref: MA:0000358 +xref: MAT:0000097 +xref: MESH:D008099 +xref: MIAA:0000097 +xref: NCIT:C12392 +xref: SCTID:181268008 +xref: TAO:0000123 +xref: VHOG:0000257 +xref: Wikipedia:Liver +xref: XAO:0000133 +xref: ZFA:0000123 +is_a: UBERON:0002365 ! exocrine gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005172 ! abdomen element +is_a: UBERON:0006925 ! digestive system gland +relationship: BFO:0000050 UBERON:0002423 ! part of hepatobiliary system +relationship: BFO:0000051 UBERON:0004647 ! has part liver lobule +relationship: RO:0002131 UBERON:0002405 ! overlaps immune system +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002202 UBERON:0004161 ! septum transversum +relationship: RO:0002202 UBERON:0008836 ! liver bud +relationship: RO:0002433 UBERON:0002423 ! hepatobiliary system +relationship: RO:0003000 UBERON:0001970 ! produces bile +relationship: site_of GO:0002384 ! hepatic immune response +relationship: site_of GO:0005978 ! glycogen biosynthetic process +relationship: site_of GO:0005980 ! glycogen catabolic process + +[Term] +id: UBERON:0002108 +name: small intestine +def: "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]." [ISBN:0073040584, Wikipedia:Small_intestine] +xref: AAO:0010397 +xref: BTO:0000651 +xref: CALOHA:TS-0942 +xref: EFO:0000841 +xref: EMAPA:32834 +xref: EV:0100072 +xref: FMA:7200 +xref: GAID:313 +xref: galen:SmallIntestine +xref: MA:0000337 +xref: MAT:0000047 +xref: MESH:D007421 +xref: MIAA:0000047 +xref: NCIT:C12386 +xref: SCTID:181250005 +xref: TAO:0001323 +xref: VHOG:0000055 +xref: Wikipedia:Small_intestine +xref: XAO:0000130 +xref: ZFA:0001323 +is_a: UBERON:0004921 ! subdivision of digestive tract +is_a: UBERON:0013765 ! digestive system element +relationship: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002433 UBERON:0000160 ! intestine + +[Term] +id: UBERON:0002110 +name: gallbladder +def: "An organ that aids digestion and stores bile produced by the liver[WP]." [Wikipedia:Gallbladder] +comment: Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988) +xref: AAO:0010114 +xref: BTO:0000493 +xref: CALOHA:TS-0394 +xref: EFO:0000853 +xref: EHDAA2:0000699 +xref: EHDAA:8062 +xref: EMAPA:17202 +xref: EV:0100090 +xref: FMA:7202 +xref: galen:Gallbladder +xref: MA:0000356 +xref: MAT:0000072 +xref: MESH:D005704 +xref: MIAA:0000072 +xref: NCIT:C12377 +xref: SCTID:181269000 +xref: TAO:0000208 +xref: VHOG:0000221 +xref: Wikipedia:Gallbladder +xref: XAO:0000135 +xref: ZFA:0000208 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0013765 ! digestive system element +is_a: UBERON:0017672 ! abdominal viscera +is_a: UBERON:0018707 ! bladder organ +relationship: BFO:0000050 UBERON:0002294 ! part of biliary system +relationship: RO:0002202 UBERON:0004912 ! biliary bud +relationship: RO:0002202 UBERON:0006242 ! gallbladder primordium +relationship: RO:0002433 UBERON:0001173 ! biliary tree + [Term] id: UBERON:0002111 name: artery smooth muscle tissue +def: "A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000087 +xref: CALOHA:TS-1198 +xref: EMAPA:36285 +xref: FMA:72024 +xref: MA:0000708 +xref: NCIT:C49195 is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -35018,15 +50367,52 @@ relationship: BFO:0000050 UBERON:0001637 ! part of artery [Term] id: UBERON:0002112 name: smooth muscle of esophagus +def: "A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35323 +xref: FMA:72025 +xref: MA:0001573 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0003832 ! part of esophagus muscle relationship: RO:0002433 UBERON:0001043 ! esophagus +[Term] +id: UBERON:0002114 +name: duodenum +def: "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one)." [ISBN:0815318960, Wikipedia:Duodenum] +xref: AAO:0010402 +xref: BTO:0000365 +xref: CALOHA:TS-0214 +xref: EFO:0000851 +xref: EMAPA:18852 +xref: EV:0100073 +xref: FMA:7206 +xref: GAID:284 +xref: galen:Duodenum +xref: MA:0000338 +xref: MAT:0000044 +xref: MESH:D004386 +xref: MIAA:0000044 +xref: NCIT:C12263 +xref: SCTID:181247007 +xref: VHOG:0000052 +xref: Wikipedia:Duodenum +xref: XAO:0000236 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BSPO:0001106 UBERON:0002108 ! small intestine +relationship: RO:0002150 UBERON:0001166 ! pylorus +relationship: RO:0002433 UBERON:0002108 ! small intestine + [Term] id: UBERON:0002118 name: right ovary +def: "An ovary that is part of a right side of organism [Automatically generated definition]." [OBOL:automatic] +xref: FMA:7213 +xref: MA:0001705 +xref: NCIT:C33487 +xref: SCTID:280123002 is_a: UBERON:0000992 ! ovary is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000992 ! ovary @@ -35036,6 +50422,11 @@ relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0002119 name: left ovary +def: "An ovary that is part of a left side of organism [Automatically generated definition]." [OBOL:automatic] +xref: FMA:7214 +xref: MA:0001704 +xref: NCIT:C32969 +xref: SCTID:280124008 is_a: UBERON:0000992 ! ovary is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000992 ! ovary @@ -35045,6 +50436,18 @@ relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0002128 name: superior olivary complex +def: "A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system." [ISBN:0-19-502694-2, Wikipedia:Superior_olivary_complex] +xref: BAMS:SOC +xref: BIRNLEX:1307 +xref: DHBA:12462 +xref: EMAPA:35840 +xref: EV:0100263 +xref: FMA:72247 +xref: HBA:9177 +xref: MA:0001026 +xref: MBA:398 +xref: VHOG:0001381 +xref: Wikipedia:Superior_olivary_complex is_a: UBERON:0007245 ! nuclear complex of neuraxis is_a: UBERON:0019263 ! gray matter of hindbrain relationship: BFO:0000050 UBERON:0003023 ! part of pontine tegmentum @@ -35053,6 +50456,27 @@ relationship: BFO:0000050 UBERON:0016490 ! part of auditory system [Term] id: UBERON:0002148 name: locus ceruleus +def: "The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]." [GAID:577, GO:0021703, Wikipedia:Locus_ceruleus] +xref: BAMS:CAE +xref: BAMS:LC +xref: BIRNLEX:905 +xref: BM:Pons-LC +xref: BTO:0001408 +xref: DHBA:12819 +xref: DMBA:16972 +xref: EFO:0001963 +xref: EMAPA:35502 +xref: FMA:72478 +xref: GAID:577 +xref: HBA:9148 +xref: MA:0001017 +xref: MBA:147 +xref: MESH:D008125 +xref: NCIT:C97333 +xref: SCTID:369016004 +xref: TAO:0000539 +xref: Wikipedia:Locus_ceruleus +xref: ZFA:0000539 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus is_a: UBERON:8440015 ! noradrenergic cell groups @@ -35062,6 +50486,18 @@ relationship: RO:0002215 GO:0048243 ! capable of norepinephrine secretion [Term] id: UBERON:0002149 name: superior salivatory nucleus +def: "Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703)." [BIRNLEX:1131] +xref: BAMS:SSN +xref: BAMS:SuS +xref: BIRNLEX:1131 +xref: DHBA:12435 +xref: EHDAA2:0004646 +xref: FMA:72482 +xref: HBA:9194 +xref: MA:0001027 +xref: MBA:462 +xref: SCTID:369028007 +xref: Wikipedia:Superior_salivatory_nucleus is_a: UBERON:0000126 ! cranial nerve nucleus is_a: UBERON:0004133 ! salivatory nucleus is_a: UBERON:0007635 ! nucleus of medulla oblongata @@ -35071,6 +50507,29 @@ relationship: RO:0002495 UBERON:0010125 ! future superior salivatory nucleus [Term] id: UBERON:0002165 name: endocardium +def: "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]." [GO:0003157] +comment: fixed in GO to reflect FMA. See email to David/Varsha June 18 2010 +xref: AAO:0010408 +xref: BTO:0000387 +xref: CALOHA:TS-2075 +xref: EFO:0000821 +xref: EHDAA2:0004153 +xref: EMAPA:17868 +xref: EMAPA:32686 +xref: EV:0100021 +xref: FMA:7280 +xref: GAID:550 +xref: galen:Endocardium +xref: MA:0000076 +xref: MAT:0000455 +xref: MESH:D004699 +xref: NCIT:C13004 +xref: SCTID:362013006 +xref: TAO:0001320 +xref: VHOG:0000084 +xref: Wikipedia:Endocardium +xref: XAO:0000066 +xref: ZFA:0001320 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0005983 ! heart layer relationship: BFO:0000051 UBERON:0005316 ! has part endocardial endothelium @@ -35079,6 +50538,14 @@ relationship: RO:0002495 UBERON:0007280 ! presumptive endocardium [Term] id: UBERON:0002166 name: endocardium of atrium +def: "Endocardium that is part of the atrium." [ZFIN:curator] +xref: EMAPA:32745 +xref: FMA:7284 +xref: MA:0000077 +xref: SCTID:192001005 +xref: TAO:0002169 +xref: VHOG:0000606 +xref: ZFA:0001614 is_a: UBERON:0002165 ! endocardium intersection_of: UBERON:0002165 ! endocardium intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium @@ -35088,6 +50555,16 @@ relationship: RO:0002433 UBERON:0002081 ! cardiac atrium [Term] id: UBERON:0002167 name: right lung +def: "Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]." [FMA:FMA, Wikipedia:Right_lung] +xref: EHDAA2:0001730 +xref: EHDAA:4969 +xref: EMAPA:17661 +xref: FMA:7309 +xref: MA:0000426 +xref: NCIT:C33483 +xref: SCTID:361967000 +xref: VHOG:0000301 +xref: Wikipedia:Right_lung is_a: UBERON:0002048 ! lung intersection_of: UBERON:0002048 ! lung intersection_of: BSPO:0000121 UBERON:0000170 ! pair of lungs @@ -35096,6 +50573,16 @@ relationship: BSPO:0000121 UBERON:0000170 ! pair of lungs [Term] id: UBERON:0002168 name: left lung +def: "Lung which consists of the left upper lobe and left lower lobe.[FMA]." [FMA:FMA, Wikipedia:Left_lung] +xref: EHDAA2:0000943 +xref: EHDAA:4947 +xref: EMAPA:17653 +xref: FMA:7310 +xref: MA:0000425 +xref: NCIT:C32967 +xref: SCTID:361982005 +xref: VHOG:0000618 +xref: Wikipedia:Left_lung is_a: UBERON:0002048 ! lung intersection_of: UBERON:0002048 ! lung intersection_of: BSPO:0000120 UBERON:0000170 ! pair of lungs @@ -35104,6 +50591,14 @@ relationship: BSPO:0000120 UBERON:0000170 ! pair of lungs [Term] id: UBERON:0002169 name: alveolar sac +def: "The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters." [MP:0010902, Wikipedia:Alveolar_sac] +xref: BTO:0000061 +xref: EMAPA:35119 +xref: FMA:7317 +xref: MA:0000418 +xref: NCIT:C32057 +xref: SCTID:361964007 +xref: Wikipedia:Alveolar_sac is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0000117 ! respiratory tube is_a: UBERON:0007499 ! epithelial sac @@ -35117,21 +50612,57 @@ relationship: RO:0002433 UBERON:0008874 ! pulmonary acinus [Term] id: UBERON:0002173 name: pulmonary alveolar duct +def: "The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli." [ISBN:0-683-40008-8, MGI:cwg, MP:0002271] +xref: EMAPA:32694 +xref: FMA:7341 +xref: MA:0000417 +xref: NCIT:C32056 +xref: Wikipedia:Alveolar_duct is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0006524 ! part of alveolar system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002185 name: bronchus +def: "The upper conducting airways of the lung; these airways arise from the terminus of the trachea." [ISBN:0-397-51047-0, MESH:A04.411.125, MGI:cwg, MP:0002264] +xref: BTO:0001340 +xref: CALOHA:TS-1229 +xref: EFO:0000932 +xref: EMAPA:32689 +xref: EV:0100041 +xref: FMA:7409 +xref: GAID:346 +xref: MA:0000436 +xref: MAT:0000133 +xref: MESH:D001980 +xref: MIAA:0000133 +xref: NCIT:C12683 +xref: SCTID:181215002 +xref: VHOG:0000262 +xref: Wikipedia:Bronchus +xref: XAO:0000121 is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: RO:0001025 UBERON:0002224 ! thoracic cavity -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002186 name: bronchiole +def: "The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching." [ISBN:0-397-51047-0, MGI:cwg, MP:0002267] +comment: In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole. {xref="https://github.com/obophenotype/uberon/issues/2795"} +xref: BTO:0002375 +xref: CALOHA:TS-2003 +xref: EHDAA:8171 +xref: EHDAA:8183 +xref: EHDAA:8199 +xref: EHDAA:8221 +xref: EMAPA:32697 +xref: FMA:7410 +xref: MA:0000422 +xref: NCIT:C12684 +xref: SCTID:278982001 +xref: VHOG:0000675 +xref: Wikipedia:Bronchiole is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002380 UBERON:0007196 ! tracheobronchial tree @@ -35139,53 +50670,91 @@ relationship: RO:0002380 UBERON:0007196 ! tracheobronchial tree [Term] id: UBERON:0002187 name: terminal bronchiole +def: "A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls." [ISBN:0-397-51047-0, MGI:cwg, MP:0002268, PMID:16543587] +xref: BTO:0003223 +xref: EMAPA:36282 +xref: FMA:7411 +xref: MA:0000424 +xref: NCIT:C33754 +xref: SCTID:278981008 +xref: Wikipedia:Terminal_bronchiole is_a: UBERON:0002186 ! bronchiole relationship: BFO:0000050 UBERON:0010369 ! part of secondary pulmonary lobule relationship: distally_connected_to UBERON:0002188 ! respiratory bronchiole relationship: distally_connected_to UBERON:0008874 ! pulmonary acinus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002188 name: respiratory bronchiole +def: "A bronchiole that is the first segment of the respiratory zone." [ISBN:0123813611, Wikipedia:Respiratory_bronchiole] +xref: BTO:0003222 +xref: EMAPA:35729 +xref: FMA:7412 +xref: MA:0000423 +xref: NCIT:C33465 +xref: SCTID:128517006 +xref: Wikipedia:Respiratory_bronchiole is_a: UBERON:0002186 ! bronchiole relationship: BFO:0000050 UBERON:0008874 ! part of pulmonary acinus relationship: distally_connected_to UBERON:0002173 ! pulmonary alveolar duct relationship: proximally_connected_to UBERON:0002187 ! terminal bronchiole relationship: RO:0002433 UBERON:0008874 ! pulmonary acinus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002190 name: subcutaneous adipose tissue +def: "A portion of adipose tissue that is part of the hypodermis, beneath the dermis." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0004042 +xref: EMAPA:35829 +xref: FMA:74315 +xref: MA:0000473 is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: RO:0002433 UBERON:0002072 ! hypodermis -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002193 name: hemolymphoid system +def: "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs." [http://orcid.org/0000-0002-6601-2165] +xref: CALOHA:TS-2018 +xref: EHDAA2:0004615 +xref: EMAPA:18765 +xref: FMA:74562 +xref: MA:0000013 is_a: UBERON:0000467 ! anatomical system relationship: RO:0002160 NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0002199 name: integument +def: "The dermis, epidermis and hypodermis." [Wikipedia:Integument] +xref: AAO:0000239 +xref: BTO:0000634 +xref: FMA:74657 +xref: galen:Integument +xref: TAO:0000368 +xref: VSAO:0000029 +xref: Wikipedia:Integument +xref: ZFA:0000368 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002416 ! part of integumental system relationship: BFO:0000051 UBERON:0002072 ! has part hypodermis relationship: BFO:0000051 UBERON:0002097 ! has part skin of body relationship: RO:0002007 UBERON:0000468 ! bounding layer of multicellular organism relationship: RO:0002160 NCBITaxon:7711 ! Chordata -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002200 name: vasculature of head +def: "Vasculature that is part of a head [Automatically generated definition]." [OBOL:automatic] +xref: EFO:0003656 +xref: FMA:74710 +xref: TAO:0001267 +xref: XAO:0004152 +xref: ZFA:0001267 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -35194,6 +50763,10 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0002201 name: vasculature of trunk +def: "A vasculature that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +xref: FMA:74712 +xref: TAO:0005024 +xref: ZFA:0005024 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -35202,32 +50775,59 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0002202 name: submucosa of trachea +def: "A submucosa that is part of a trachea." [OBOL:automatic] +xref: BTO:0002115 +xref: EMAPA:35879 +xref: FMA:7472 +xref: MA:0001860 +xref: NCIT:C49307 +xref: SCTID:4419000 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002203 name: vasculature of eye +def: "Vasculature that is part of the eye region." [https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726, OBOL:automatic] +xref: FMA:74743 +xref: SCTID:123846009 +xref: TAO:0007057 +xref: ZFA:0007057 is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: RO:0002202 UBERON:0003314 ! eye mesenchyme -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002204 name: musculoskeletal system +def: "Anatomical system that consists of the muscular and skeletal systems." [https://github.com/obophenotype/uberon/issues/77, VSAO:0000031, VSAO:curator] +xref: AAO:0010546 +xref: CALOHA:TS-1311 +xref: EMAPA:32714 +xref: EV:0100139 +xref: FMA:7482 +xref: GAID:98 +xref: MA:0002418 +xref: MESH:D009141 +xref: NCIT:C12754 +xref: SCTID:278858007 +xref: VHOG:0001275 +xref: VSAO:0000031 +xref: Wikipedia:Musculoskeletal_system +xref: XAO:0000168 is_a: UBERON:0000467 ! anatomical system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 UBERON:0000383 ! has part musculature of body @@ -35239,6 +50839,14 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0002213 name: cartilaginous joint +def: "Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]." [FMA:FMA, Wikipedia:Cartilaginous_joint] +xref: EMAPA:36581 +xref: FMA:7496 +xref: MA:0000320 +xref: SCTID:58442004 +xref: TAO:0005155 +xref: Wikipedia:Cartilaginous_joint +xref: ZFA:0005155 is_a: UBERON:0011134 ! nonsynovial joint intersection_of: UBERON:0011134 ! nonsynovial joint intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue @@ -35247,6 +50855,18 @@ relationship: RO:0002473 UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0002217 name: synovial joint +def: "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]." [FMA:7501, Wikipedia:Synovial_joint] +xref: AEO:0000183 +xref: CALOHA:TS-2138 +xref: EHDAA2:0003183 +xref: FMA:7501 +xref: galen:SynovialJoint +xref: MA:0000322 +xref: NCIT:C32461 +xref: SCTID:113234001 +xref: TAO:0005153 +xref: Wikipedia:Synovial_joint +xref: ZFA:0005153 is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002219 UBERON:0001484 ! articular capsule @@ -35257,6 +50877,15 @@ relationship: RO:0002219 UBERON:0001484 ! articular capsule [Term] id: UBERON:0002224 name: thoracic cavity +def: "The part of the coelemic cavity lumen that is enclosed by the walls of the thorax." [UBERON:cjm, Wikipedia:Thoracic_cavity] +xref: EMAPA:36497 +xref: FMA:7565 +xref: GAID:93 +xref: MA:0000032 +xref: MESH:D035423 +xref: NCIT:C12905 +xref: SCTID:243949006 +xref: Wikipedia:Thoracic_cavity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen @@ -35267,6 +50896,34 @@ relationship: RO:0002572 UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0002240 name: spinal cord +def: "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO)." [BIRNLEX:1709] +xref: AAO:0010151 +xref: BAMS:SP +xref: BAMS:Spinal +xref: BIRNLEX:1709 +xref: BM:SpC +xref: BTO:0001279 +xref: CALOHA:TS-0953 +xref: DHBA:12890 +xref: DMBA:17651 +xref: EFO:0000110 +xref: EHDAA2:0001255 +xref: EHDAA:2863 +xref: EMAPA:17577 +xref: EV:0100316 +xref: FMA:7647 +xref: GAID:695 +xref: MA:0000216 +xref: MAT:0000183 +xref: MESH:D013116 +xref: MIAA:0000183 +xref: NCIT:C12464 +xref: SCTID:180959008 +xref: TAO:0000075 +xref: VHOG:0000601 +xref: Wikipedia:Spinal_cord +xref: XAO:0000020 +xref: ZFA:0000075 is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005174 ! dorsal region element @@ -35276,17 +50933,39 @@ relationship: BFO:0000051 CL:0005000 ! has part spinal cord interneuron relationship: RO:0002202 UBERON:0003076 ! posterior neural tube relationship: RO:0002254 UBERON:0003853 ! spinal cord neural crest relationship: RO:0002495 UBERON:0006241 ! future spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002241 name: chondrocranium +def: "Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]." [http://medical-dictionary.thefreedictionary.com/chondrocranium, Wikipedia:Chondrocranium] +xref: AAO:0010169 +xref: EHDAA2:0000243 +xref: EMAPA:17681 +xref: TAO:0001424 +xref: VHOG:0000288 +xref: Wikipedia:Chondrocranium +xref: ZFA:0001424 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system relationship: RO:0002131 UBERON:0001703 ! overlaps neurocranium [Term] id: UBERON:0002257 name: ventral horn of spinal cord +def: "The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]." [GO:0021517, https://sourceforge.net/tracker/?group_id=36855&atid=440764, MP:0005112, Wikipedia:Anterior_horn_of_spinal_cord] +xref: BAMS:VH +xref: BIRNLEX:2668 +xref: BTO:0005151 +xref: EMAPA:18575 +xref: EMAPA:35794 +xref: FMA:256541 +xref: MA:0001134 +xref: NCIT:C33859 +xref: neuronames:1751 +xref: SCTID:279443000 +xref: TAO:0000702 +xref: VHOG:0001288 +xref: Wikipedia:Anterior_horn_of_spinal_cord +xref: ZFA:0000702 is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0016550 ! spinal cord column relationship: BFO:0000050 UBERON:0002315 ! part of gray matter of spinal cord @@ -35297,12 +50976,89 @@ relationship: RO:0002433 UBERON:0002315 ! gray matter of spinal cord [Term] id: UBERON:0002275 name: reticular formation +def: "A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 )." [NeuroNames:1223] +xref: BAMS:RET +xref: EMAPA:35188 +xref: FMA:77719 +xref: MA:0003185 +xref: MESH:D012154 +xref: neuronames:1223 +xref: NLX:143558 +xref: SCTID:361552007 +xref: Wikipedia:Reticular_formation is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002298 ! part of brainstem +[Term] +id: UBERON:0002294 +name: biliary system +def: "Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree)." [Wikipedia:Biliary_system] +xref: FMA:79646 +xref: GAID:279 +xref: MA:0001273 +xref: MESH:D001659 +xref: NCIT:C12678 +xref: SCTID:361354009 +xref: Wikipedia:Biliary_system +is_a: UBERON:0011216 ! organ system subdivision +intersection_of: UBERON:0011216 ! organ system subdivision +intersection_of: BFO:0000051 UBERON:0001173 ! has part biliary tree +intersection_of: RO:0002215 GO:0006699 ! capable of bile acid biosynthetic process +intersection_of: RO:0002215 GO:0015721 ! capable of bile acid and bile salt transport +disjoint_from: UBERON:0002330 ! exocrine system +disjoint_from: UBERON:0002390 ! hematopoietic system +disjoint_from: UBERON:0002405 ! immune system +disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system +disjoint_from: UBERON:0004456 ! entire sense organ system +disjoint_from: UBERON:8450002 ! excretory system +relationship: BFO:0000050 UBERON:0002423 ! part of hepatobiliary system +relationship: BFO:0000051 UBERON:0001173 ! has part biliary tree +relationship: RO:0002215 GO:0006699 ! capable of bile acid biosynthetic process +relationship: RO:0002215 GO:0015721 ! capable of bile acid and bile salt transport + +[Term] +id: UBERON:0002296 +name: dorsal mesentery +def: "The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]." [Wikipedia:Dorsal_mesentery, Wikipedia:Mesentery#Development, ZFIN:curator] +xref: EHDAA2:0004560 +xref: EHDAA:3019 +xref: EHDAA:3033 +xref: EHDAA:3921 +xref: EHDAA:3934 +xref: EHDAA:3957 +xref: EHDAA:3971 +xref: FMA:79795 +xref: SCTID:308823000 +xref: TAO:0005130 +xref: Wikipedia:Mesentery#Development +xref: ZFA:0005130 +is_a: UBERON:0006598 ! presumptive structure +relationship: BFO:0000050 UBERON:0009664 ! part of gut mesentery +relationship: RO:0002387 UBERON:0002095 ! mesentery + [Term] id: UBERON:0002298 name: brainstem +def: "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]." [ISBN:0471888893, MP:0005277, Wikipedia:Brainstem, ZFA:0001707] +comment: 'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions). +xref: BAMS:BS +xref: BIRNLEX:1565 +xref: BTO:0000146 +xref: CALOHA:TS-0093 +xref: EFO:0001962 +xref: EMAPA:32678 +xref: EV:0100241 +xref: FMA:79876 +xref: MA:0000169 +xref: MBA:343 +xref: MESH:D001933 +xref: NCIT:C12441 +xref: SCTID:180925009 +xref: TAO:0002156 +xref: VHOG:0001457 +xref: Wikipedia:Brainstem +xref: ZFA:0001707 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000051 UBERON:0001896 ! has part medulla oblongata relationship: BFO:0000051 UBERON:0001943 ! has part midbrain tegmentum @@ -35312,6 +51068,18 @@ relationship: RO:0002433 UBERON:0000955 ! brain [Term] id: UBERON:0002299 name: alveolus of lung +def: "Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]." [Wikipedia:Pulmonary_alveolus] +xref: BTO:0000060 +xref: CALOHA:TS-0031 +xref: EFO:0001985 +xref: EMAPA:32682 +xref: FMA:7318 +xref: GAID:349 +xref: MA:0000420 +xref: MESH:D011650 +xref: SCTID:361364000 +xref: VHOG:0001445 +xref: Wikipedia:Pulmonary_alveolus is_a: UBERON:0003215 ! alveolus is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0003215 ! alveolus @@ -35321,11 +51089,19 @@ relationship: BFO:0000050 UBERON:0008874 ! part of pulmonary acinus relationship: BFO:0000067 GO:0007585 ! respiratory gaseous exchange by respiratory system relationship: RO:0002160 NCBITaxon:40674 ! Mammalia relationship: RO:0002433 UBERON:0008874 ! pulmonary acinus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002302 name: myocardium of atrium +def: "The atrial part of middle layer of the heart, comprised of involuntary muscle." [ISBN:0-683-40008-8, MP:0010493] +xref: EFO:0003087 +xref: EMAPA:32746 +xref: FMA:83509 +xref: MA:0000081 +xref: SCTID:191910002 +xref: TAO:0001374 +xref: VHOG:0000602 +xref: ZFA:0001374 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium @@ -35335,6 +51111,13 @@ relationship: RO:0002433 UBERON:0002081 ! cardiac atrium [Term] id: UBERON:0002308 name: nucleus of brain +def: "A neural nucleus that is part of the brain." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:35185 +xref: FMA:83840 +xref: MA:0000811 +xref: NCIT:C49346 +xref: SCTID:426465002 +xref: ZFA:0005575 is_a: UBERON:0000125 ! neural nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: BFO:0000050 UBERON:0000955 ! part of brain @@ -35343,6 +51126,16 @@ relationship: BFO:0000050 UBERON:0003528 ! part of brain gray matter [Term] id: UBERON:0002315 name: gray matter of spinal cord +def: "The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue." [MP:0008503] +xref: BAMS:Scgrey +xref: DHBA:146035048 +xref: EMAPA:35792 +xref: FMA:256580 +xref: MA:0000002 +xref: NCIT:C32696 +xref: neuronames:2619 +xref: NLXANAT:100204 +xref: SCTID:279441003 is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord @@ -35352,6 +51145,18 @@ relationship: RO:0002433 UBERON:0002240 ! spinal cord [Term] id: UBERON:0002323 name: coelemic cavity lumen +def: "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities." [BTO:0001707] +comment: EDITOR_NOTE check the FMA placement here; ncit placement of body cavity here probably not correct +xref: AEO:0000186 +xref: BTO:0001707 +xref: EHDAA2:0000267 +xref: FMA:85006 +xref: galen:BodyCavity +xref: NCIT:C25444 +xref: RETIRED_EHDAA2:0003186 +xref: SCTID:361348008 +xref: TAO:0001438 +xref: ZFA:0001438 is_a: UBERON:0002553 ! anatomical cavity relationship: RO:0002494 UBERON:0003886 ! future coelemic cavity lumen relationship: RO:0002572 UBERON:0011997 ! coelom @@ -35359,16 +51164,42 @@ relationship: RO:0002572 UBERON:0011997 ! coelom [Term] id: UBERON:0002324 name: muscle of back +def: "Any muscle organ that is part of a back [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35161 +xref: FMA:85216 +xref: MA:0000496 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005174 ! dorsal region element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0004469 ! part of musculature of back -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002328 name: notochord +def: "A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube." [http://tolweb.org/Chordata/2499, https://github.com/obophenotype/uberon/issues/25, https://github.com/obophenotype/uberon/issues/271, ISBN:0815318960, Wikipedia:Notochord] +comment: The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB] +xref: AAO:0000327 +xref: BTO:0001768 +xref: CALOHA:TS-0690 +xref: EHDAA2:0001277 +xref: EHDAA:1241 +xref: EHDAA:6021 +xref: EMAPA:16191 +xref: EV:0100002 +xref: FMA:85521 +xref: GAID:1311 +xref: http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg +xref: MAT:0000281 +xref: MESH:D009672 +xref: NCIT:C12463 +xref: SCTID:308820002 +xref: TAO:0000135 +xref: VHOG:0000199 +xref: VSAO:0000032 +xref: Wikipedia:Notochord +xref: XAO:0000055 +xref: ZFA:0000135 is_a: UBERON:0000062 ! organ is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure @@ -35386,6 +51217,26 @@ relationship: RO:0003000 PR:000014841 ! produces [Term] id: UBERON:0002329 name: somite +def: "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm." [DOI:10.1111/j.1439-0426.2012.01987.x, Wikipedia:Somite] +comment: When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248] +xref: AAO:0010569 +xref: AEO:0001015 +xref: BTO:0001558 +xref: EHDAA2:0003436 +xref: EHDAA:366 +xref: EHDAA:699 +xref: EMAPA:31169 +xref: FMA:85522 +xref: GAID:1306 +xref: MAT:0000068 +xref: MESH:D019170 +xref: MIAA:0000068 +xref: NCIT:C34302 +xref: TAO:0000155 +xref: VHOG:0000191 +xref: Wikipedia:Somite +xref: XAO:0000058 +xref: ZFA:0000155 is_a: UBERON:0005423 ! developing anatomical structure is_a: UBERON:0007503 ! epithelial vesicle relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -35394,10 +51245,20 @@ relationship: RO:0002202 UBERON:0003059 ! presomitic mesoderm [Term] id: UBERON:0002330 name: exocrine system +def: "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]." [Wikipedia:Exocrine_gland] +xref: CALOHA:TS-2057 +xref: EHDAA2:0002225 +xref: EMAPA:35329 +xref: FMA:85539 +xref: MA:0002411 +xref: NCIT:C12957 +xref: Wikipedia:Exocrine_gland +xref: WikipediaCategory:Exocrine_system is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa @@ -35407,16 +51268,29 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0002333 name: pulmonary trunk +def: "An arterial trunk which is continuous with the heart and branches into the pulmonary arteries." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0001576 +xref: EHDAA:9831 +xref: EMAPA:17015 +xref: FMA:8612 +xref: galen:PulmonaryTrunk +xref: MA:0002033 +xref: NCIT:C116918 +xref: VHOG:0001134 is_a: UBERON:0001637 ! artery relationship: BFO:0000050 UBERON:0008886 ! part of pulmonary vascular system relationship: RO:0002150 UBERON:0000948 ! heart relationship: RO:0002150 UBERON:0002080 {gci_filler="NCBITaxon:40674", gci_relation="BFO:0000050"} ! heart right ventricle relationship: RO:0002170 UBERON:0002080 ! heart right ventricle -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002338 name: lamina propria of bronchus +def: "A lamina propria that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35194 +xref: FMA:86619 +xref: MA:0001836 +xref: NCIT:C49212 is_a: UBERON:0000031 ! lamina propria of trachea is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000030 ! lamina propria @@ -35426,6 +51300,25 @@ relationship: BFO:0000050 UBERON:0000410 ! part of bronchial mucosa [Term] id: UBERON:0002342 name: neural crest +def: "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]." [MP:0009846] +comment: Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. +xref: AAO:0010578 +xref: BTO:0001764 +xref: CALOHA:TS-0676 +xref: EHDAA2:0004419 +xref: EMAPA:32737 +xref: FMA:86666 +xref: GAID:1310 +xref: MAT:0000066 +xref: MESH:D009432 +xref: MIAA:0000066 +xref: NCIT:C34222 +xref: neuronames:1366 +xref: SCTID:361462002 +xref: VHOG:0000057 +xref: Wikipedia:Neural_crest +xref: XAO:0000048 +xref: ZFA:0000045 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010316 ! germ layer / neural crest @@ -35439,6 +51332,11 @@ relationship: RO:0002488 UBERON:0000110 ! neurula stage [Term] id: UBERON:0002343 name: abdomen musculature +def: "Set of all muscles in abdomen." [OBOL:automatic] +xref: FMA:71294 +xref: FMA:86917 +xref: TAO:0001327 +xref: ZFA:0001327 is_a: UBERON:0004479 ! musculature of trunk intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -35447,35 +51345,112 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0002345 name: descending thoracic aorta +def: "The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." [MP:0009868] +xref: EFO:0002527 +xref: EMAPA:18605 +xref: FMA:87217 +xref: MA:0002572 +xref: SCTID:181301002 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0001514 ! part of descending aorta relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta relationship: RO:0002433 UBERON:0001514 ! descending aorta relationship: RO:0002433 UBERON:0001515 ! thoracic aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002346 name: neurectoderm +def: "Embryonic ectoderm that gives rise to nervous tissue." [Wikipedia:Neuroectoderm] +xref: AAO:0011074 +xref: BILA:0000039 +xref: CALOHA:TS-1212 +xref: EHDAA2:0001248 +xref: EHDAA:1498 +xref: EHDAA:255 +xref: EMAPA:16073 +xref: EV:0100004 +xref: FMA:87657 +xref: MAT:0000176 +xref: MIAA:0000176 +xref: NCIT:C34228 +xref: TAO:0001120 +xref: VHOG:0000150 +xref: Wikipedia:Neuroectoderm +xref: XAO:0000042 +xref: ZFA:0001120 is_a: UBERON:0000923 ! germ layer is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000051 CL:0000133 ! has part neurectodermal cell +[Term] +id: UBERON:0002347 +name: thoracic vertebra +def: "A thoracic vertebra endochondral element that is composed primarily of a bone tissue." [OBOL:automatic] +xref: EMAPA:18011 +xref: FMA:9139 +xref: GAID:244 +xref: MA:0000314 +xref: MESH:D013904 +xref: NCIT:C12798 +xref: SCTID:181821009 +xref: Wikipedia:Thoracic_vertebrae +is_a: UBERON:0002412 ! vertebra +is_a: UBERON:0003827 ! thoracic segment bone +is_a: UBERON:0004247 ! bone of dorsum +is_a: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002481 ! bone tissue +relationship: RO:0002202 UBERON:0013507 ! thoracic vertebra cartilage element + [Term] id: UBERON:0002348 name: epicardium +def: "A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart." [http://orcid.org/0000-0002-6601-2165] +comment: EDITOR_NOTE TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer. +xref: AAO:0010409 +xref: EHDAA2:0002202 +xref: FMA:9461 +xref: galen:Epicardium +xref: NCIT:C13164 +xref: TAO:0005057 +xref: VHOG:0000119 +xref: Wikipedia:Epicardium +xref: XAO:0000316 +xref: ZFA:0005057 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0002425 ! part of visceral serous pericardium relationship: RO:0002202 UBERON:0004160 ! proepicardium relationship: RO:0002371 UBERON:0002349 ! myocardium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002349 name: myocardium +def: "The middle layer of the heart, comprised mainly of striated cardiac muscle fibers." [ISBN:0-683-40008-8, MP:0005329] +comment: EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium +xref: AAO:0010410 +xref: BSA:0000089 +xref: BTO:0000901 +xref: CALOHA:TS-0440 +xref: EFO:0000819 +xref: EHDAA2:0004150 +xref: EV:0100022 +xref: FMA:9462 +xref: GAID:173 +xref: galen:Myocardium +xref: MA:0000164 +xref: MAT:0000453 +xref: MESH:D009206 +xref: NCIT:C12371 +xref: RETIRED_EHDAA2:0001220 +xref: SCTID:362012001 +xref: TAO:0001319 +xref: VHOG:0000083 +xref: Wikipedia:Myocardium +xref: XAO:0000065 +xref: ZFA:0001319 is_a: UBERON:0005983 ! heart layer is_a: UBERON:0018260 ! layer of muscle tissue intersection_of: UBERON:0005983 ! heart layer @@ -35487,6 +51462,18 @@ relationship: RO:0002473 UBERON:0001133 ! cardiac muscle tissue [Term] id: UBERON:0002350 name: conducting system of heart +def: "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]." [GO:0003161] +xref: EFO:0003909 +xref: EHDAA2:0004185 +xref: EMAPA:35428 +xref: EV:0100025 +xref: FMA:9476 +xref: MA:0000094 +xref: MESH:D006329 +xref: SCTID:281489000 +xref: TAO:0005063 +xref: VHOG:0001271 +xref: ZFA:0005063 is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 ! conducting tissue of heart relationship: BFO:0000051 CL:0002068 ! has part Purkinje myocyte @@ -35499,6 +51486,20 @@ relationship: RO:0002433 UBERON:0000948 ! heart [Term] id: UBERON:0002351 name: sinoatrial node +def: "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]." [GO:0003163, Wikipedia:Sinoatrial_node] +comment: WP:Heart states: "The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.". Note however that ZFA has SA node. +xref: BTO:0004358 +xref: EHDAA2:0004184 +xref: EMAPA:35772 +xref: FMA:9477 +xref: GAID:561 +xref: MA:0000097 +xref: MESH:D012849 +xref: NCIT:C33555 +xref: SCTID:277687007 +xref: TAO:0005069 +xref: Wikipedia:Sinoatrial_node +xref: ZFA:0005069 is_a: UBERON:0003379 ! cardiac muscle of right atrium is_a: UBERON:0010131 ! conducting tissue of heart relationship: BFO:0000050 UBERON:0002350 ! part of conducting system of heart @@ -35506,11 +51507,26 @@ relationship: RO:0002162 NCBITaxon:7742 ! Vertebrata relationship: RO:0002215 GO:0002027 ! capable of regulation of heart rate relationship: RO:0002216 GO:0060048 ! capable of part of cardiac muscle contraction relationship: RO:0002433 UBERON:0002350 ! conducting system of heart -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002352 name: atrioventricular node +def: "An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles." [UBERON:cjm, Wikipedia:Atrioventricular_node] +xref: BTO:0005689 +xref: EFO:0000276 +xref: EHDAA2:0004183 +xref: EMAPA:35153 +xref: FMA:9478 +xref: GAID:558 +xref: MA:0000095 +xref: MAT:0000498 +xref: MESH:D001283 +xref: NCIT:C32161 +xref: SCTID:277688002 +xref: TAO:0005070 +xref: VHOG:0001474 +xref: Wikipedia:Atrioventricular_node +xref: ZFA:0005070 is_a: UBERON:0004491 ! cardiac muscle tissue of interatrial septum is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 ! conducting tissue of heart @@ -35518,11 +51534,19 @@ relationship: BFO:0000050 UBERON:0002350 ! part of conducting system of heart relationship: RO:0002170 UBERON:0002085 ! interatrial septum relationship: RO:0002170 UBERON:0005979 ! crista terminalis relationship: RO:0002433 UBERON:0002350 ! conducting system of heart -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002354 name: cardiac Purkinje fiber +def: "The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GO:0003165] +xref: BTO:0001735 +xref: EMAPA:35718 +xref: FMA:9492 +xref: GAID:560 +xref: MA:0000096 +xref: MESH:D011690 +xref: NCIT:C33430 +xref: Wikipedia:Purkinje_fiber is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BFO:0000050 UBERON:8000009 ! part of Purkinje fiber network @@ -35532,6 +51556,12 @@ relationship: RO:0002433 UBERON:0002350 ! conducting system of heart [Term] id: UBERON:0002357 name: serous pericardium +def: "Serous membrane which is divided into parietal and visceral serous pericardium." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Serous_pericardium] +xref: EMAPA:19030 +xref: FMA:9582 +xref: MA:0002739 +xref: SCTID:243954002 +xref: Wikipedia:Serous_pericardium is_a: UBERON:0000042 ! serous membrane relationship: BFO:0000050 UBERON:0002406 ! part of pericardial sac relationship: BFO:0000051 UBERON:0002408 ! has part parietal serous pericardium @@ -35541,6 +51571,22 @@ relationship: RO:0002371 UBERON:0002359 ! fibrous pericardium [Term] id: UBERON:0002358 name: peritoneum +def: "A serous membrane that lines the peritoneal cavity[VHOG,modified]." [VHOG:0001257] +xref: AAO:0010814 +xref: BTO:0001472 +xref: CALOHA:TS-2072 +xref: EV:0100087 +xref: FMA:9584 +xref: GAID:18 +xref: galen:Peritoneum +xref: MA:0000449 +xref: MESH:D010537 +xref: NCIT:C12770 +xref: TAO:0005120 +xref: VHOG:0001257 +xref: Wikipedia:Peritoneum +xref: XAO:0000139 +xref: ZFA:0005120 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0035820 ! part of peritoneal sac @@ -35550,6 +51596,12 @@ relationship: BFO:0000050 UBERON:0035820 ! part of peritoneal sac [Term] id: UBERON:0002359 name: fibrous pericardium +def: "Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]." [FMA:9586] +xref: EMAPA:19029 +xref: FMA:9586 +xref: MA:0002738 +xref: SCTID:243953008 +xref: Wikipedia:Fibrous_pericardium is_a: UBERON:0000094 ! membrane organ is_a: UBERON:0005181 ! thoracic segment organ relationship: BFO:0000050 UBERON:0002407 ! part of pericardium @@ -35559,6 +51611,19 @@ relationship: RO:0002473 UBERON:0006815 ! areolar connective tissue [Term] id: UBERON:0002365 name: exocrine gland +def: "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas." [Wikipedia:Exocrine_gland] +xref: AEO:0000097 +xref: BTO:0000765 +xref: CALOHA:TS-2012 +xref: EHDAA2:0003097 +xref: EMAPA:35327 +xref: FMA:9596 +xref: GAID:34 +xref: MA:0002564 +xref: MESH:D005088 +xref: NCIT:C12712 +xref: SCTID:115976003 +xref: Wikipedia:Exocrine_gland is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002330 ! part of exocrine system @@ -35568,6 +51633,19 @@ relationship: BFO:0000051 UBERON:0000058 ! has part duct [Term] id: UBERON:0002368 name: endocrine gland +def: "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]." [Wikipedia:Endocrine_gland] +xref: AEO:0000098 +xref: BTO:0001488 +xref: CALOHA:TS-1300 +xref: EHDAA2:0003098 +xref: EMAPA:35999 +xref: FMA:9602 +xref: GAID:335 +xref: MA:0002563 +xref: MESH:D004702 +xref: NCIT:C12704 +xref: SCTID:40818001 +xref: Wikipedia:Endocrine_gland is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000949 ! part of endocrine system @@ -35577,6 +51655,26 @@ relationship: RO:0002215 GO:0046879 ! capable of hormone secretion [Term] id: UBERON:0002371 name: bone marrow +def: "The soft tissue that fills the cavities of bones." [MGI:cwg, MP:0002397] +xref: AAO:0011007 +xref: BTO:0000141 +xref: BTO:0000829 +xref: CALOHA:TS-0087 +xref: EFO:0000868 +xref: EMAPA:32760 +xref: EV:0100046 +xref: FMA:9608 +xref: GAID:1287 +xref: galen:BoneMarrow +xref: MA:0000134 +xref: MAT:0000084 +xref: MESH:D001853 +xref: MIAA:0000084 +xref: NCIT:C12431 +xref: SCTID:421320006 +xref: VHOG:0001218 +xref: Wikipedia:Bone_marrow +xref: XAO:0000123 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000479 ! tissue @@ -35587,11 +51685,21 @@ relationship: BFO:0000050 UBERON:0002390 ! part of hematopoietic system relationship: BFO:0000050 UBERON:0002405 ! part of immune system relationship: BFO:0000051 CL:0002092 ! has part bone marrow cell relationship: BFO:0000051 UBERON:0012429 ! has part hematopoietic tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002376 name: cranial muscle +def: "Any skeletal muscle that is part of the head region." [http://orcid.org/0000-0002-6601-2165] +comment: defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984) +xref: AAO:0000107 +xref: BTO:0000021 +xref: EFO:0003524 +xref: EHDAA2:0000322 +xref: EMAPA:18172 +xref: FMA:9616 +xref: MA:0000578 +xref: SCTID:244718003 +xref: ZFA:0001652 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010959 ! craniocervical muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate @@ -35600,38 +51708,83 @@ intersection_of: RO:0002371 UBERON:0003129 ! skull relationship: BFO:0000050 UBERON:0004461 ! part of skeletal musculature of head relationship: RO:0002202 UBERON:0006904 ! head mesenchyme from mesoderm relationship: RO:0002371 UBERON:0003129 ! skull -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002377 name: muscle of neck +def: "Any muscle that is part of the cervical (neck) region." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:9617 +xref: GAID:149 +xref: MA:0000587 +xref: MESH:D009334 +xref: NCIT:C33163 is_a: UBERON:0010959 ! craniocervical muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0004465 ! part of musculature of neck -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002378 name: muscle of abdomen +def: "Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis." [Wikipedia:Abdominal_muscle] +xref: BTO:0001261 +xref: EMAPA:35103 +xref: FMA:9620 +xref: GAID:89 +xref: MA:0000520 +xref: MESH:D000009 +xref: NCIT:C32040 +xref: SCTID:361352008 +xref: Wikipedia:Abdominal_muscle is_a: UBERON:0003833 ! abdominal segment muscle is_a: UBERON:0005172 ! abdomen element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0002343 ! part of abdomen musculature relationship: BFO:0000050 UBERON:0003697 ! part of abdominal wall -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002384 name: connective tissue +def: "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/23, PSPUB:0000170, VSAO:0000017] +xref: AAO:0000098 +xref: BTO:0000421 +xref: CALOHA:TS-2009 +xref: EFO:0000952 +xref: EMAPA:35251 +xref: FMA:9640 +xref: GAID:100 +xref: galen:ConnectiveTissue +xref: MA:0000011 +xref: MAT:0000301 +xref: MESH:D003238 +xref: MIAA:0000301 +xref: NCIT:C12374 +xref: SCTID:361919005 +xref: TAO:0001641 +xref: VSAO:0000017 +xref: XAO:0001017 +xref: ZFA:0001632 is_a: UBERON:0000479 ! tissue relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002385 name: muscle tissue +def: "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." [GO:0060537, https://sourceforge.net/tracker/index.php?func=detail&aid=2801266&group_id=36855&atid=440764, Wikipedia:Muscle_tissue] +comment: Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach. +xref: AAO:0000306 +xref: AEO:0000122 +xref: CALOHA:TS-0642 +xref: EHDAA2:0003122 +xref: EMAPA:32715 +xref: FMA:9641 +xref: galen:MuscleTissue +xref: MA:0002437 +xref: MESH:D009132 +xref: NCIT:C12435 +xref: SCTID:91727004 +xref: Wikipedia:Muscle_tissue is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000479 ! tissue @@ -35645,20 +51798,97 @@ relationship: RO:0002473 CL:0000187 ! muscle cell [Term] id: UBERON:0002390 name: hematopoietic system +def: "Anatomical system that is involved in the production of hematopoietic cells." [Wikipedia:Haematopoiesis] +xref: AAO:0011002 +xref: BTO:0000570 +xref: CALOHA:TS-0449 +xref: EFO:0000798 +xref: EMAPA:35402 +xref: EV:0100045 +xref: FMA:9667 +xref: GAID:1008 +xref: MA:0002434 +xref: MAT:0000022 +xref: MESH:D006413 +xref: MIAA:0000022 +xref: NCIT:C12909 +xref: SCTID:362587009 +xref: TAO:0005023 +xref: VHOG:0001624 +xref: Wikipedia:Haematopoiesis +xref: XAO:0000122 +xref: ZFA:0005023 is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004120 ! mesoderm-derived structure disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system relationship: RO:0002160 NCBITaxon:7711 ! Chordata relationship: RO:0002202 UBERON:0003061 ! blood island -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002394 +name: bile duct +def: "Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Bile_duct] +xref: AAO:0011019 +xref: BTO:0000122 +xref: CALOHA:TS-0075 +xref: EMAPA:35171 +xref: EV:0100091 +xref: FMA:9706 +xref: GAID:280 +xref: MA:0000354 +xref: MESH:D001652 +xref: NCIT:C12376 +xref: SCTID:276157007 +xref: TAO:0001100 +xref: VHOG:0000212 +xref: Wikipedia:Bile_duct +xref: XAO:0000134 +xref: ZFA:0001100 +is_a: UBERON:0000025 ! tube +is_a: UBERON:0003928 ! digestive system duct +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000058 ! duct +intersection_of: BFO:0000050 UBERON:0001173 ! part of biliary tree +relationship: BFO:0000050 UBERON:0001173 ! part of biliary tree +relationship: channel_for UBERON:0001970 ! bile +relationship: RO:0002202 UBERON:0008835 ! hepatic diverticulum +relationship: RO:0002433 UBERON:0001173 ! biliary tree + +[Term] +id: UBERON:0002396 +name: vomer +def: "The triangular flat bone of the nasal septum." [ISBN:0-683-40008-8, MP:0000098] +xref: AAO:0000633 +xref: FMA:9710 +xref: MA:0001496 +xref: NCIT:C33888 +xref: SCTID:272678009 +xref: TAO:0000308 +xref: Wikipedia:Vomer +xref: ZFA:0000308 +is_a: UBERON:0008001 ! irregular bone +is_a: UBERON:0011597 ! bone of upper jaw +is_a: UBERON:0012071 ! palate bone +relationship: BFO:0000050 UBERON:0011085 ! part of palatoquadrate arch +relationship: RO:0002433 UBERON:0011156 ! facial skeleton [Term] id: UBERON:0002400 name: parietal pleura +def: "The outer serous membrane of the pulmonary pleural." [UBERON:cjm, Wikipedia:Pulmonary_pleurae] +comment: the part of the pleura external to the visceral pleura. It lines the inner surface of the chest wall, covers the diaphragm, and is reflected over the structures occupying the middle of the thorax +xref: EMAPA:16776 +xref: FMA:9733 +xref: MA:0002488 +xref: NCIT:C33273 +xref: SCTID:361998003 +xref: VHOG:0001495 +xref: Wikipedia:Parietal_pleura is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -35672,6 +51902,14 @@ relationship: RO:0002433 UBERON:0000977 ! pleura [Term] id: UBERON:0002401 name: visceral pleura +def: "The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs." [UBERON:cjm, Wikipedia:Pulmonary_pleurae] +xref: EHDAA2:0002205 +xref: EMAPA:16777 +xref: FMA:9734 +xref: MA:0002489 +xref: NCIT:C33881 +xref: SCTID:361997008 +xref: VHOG:0001496 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0004923 ! organ component layer @@ -35682,11 +51920,23 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002220 UBERON:0002048 ! adjacent to lung relationship: RO:0002371 UBERON:0008946 ! lung parenchyma relationship: RO:0002433 UBERON:0000977 ! pleura -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002402 name: pleural cavity +def: "The fluid-filled cavity that lies between the visceral and parietal pleurae." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Pleural_cavity] +xref: BTO:0004422 +xref: EHDAA2:0001475 +xref: EMAPA:16773 +xref: EMAPA:16774 +xref: FMA:9740 +xref: GAID:95 +xref: MA:0000055 +xref: MESH:D035422 +xref: NCIT:C12840 +xref: SCTID:361999006 +xref: VHOG:0000581 +xref: Wikipedia:Pleural_cavity is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0009778 ! pleural sac @@ -35698,18 +51948,37 @@ relationship: RO:0002572 UBERON:0009778 ! pleural sac [Term] id: UBERON:0002405 name: immune system +def: "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." [Wikipedia:Immune_system] +xref: AAO:0011003 +xref: BILA:0000104 +xref: BTO:0005810 +xref: FMA:9825 +xref: GAID:328 +xref: MA:0002711 +xref: MESH:D007107 +xref: NCIT:C12735 +xref: SCTID:362590003 +xref: TAO:0001159 +xref: VHOG:0001247 +xref: Wikipedia:Immune_system +xref: XAO:0003152 +xref: ZFA:0001159 is_a: UBERON:0015203 ! non-connected functional system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: protects UBERON:0000468 ! multicellular organism relationship: RO:0002215 GO:0002376 ! capable of immune system process relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002406 name: pericardial sac +def: "A double-walled sac containing the heart and the roots of the great vessels." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Pericardium] +xref: FMA:9868 +xref: RETIRED_EHDAA2:0001443 +xref: SCTID:361326002 is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0005906 ! serous sac intersection_of: UBERON:0005906 ! serous sac @@ -35723,16 +51992,46 @@ relationship: RO:0002219 UBERON:0002359 ! fibrous pericardium [Term] id: UBERON:0002407 name: pericardium +def: "The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Pericardium] +xref: AAO:0010817 +xref: BSA:0000090 +xref: BTO:0000717 +xref: CALOHA:TS-0761 +xref: EFO:0000820 +xref: EHDAA:5376 +xref: EV:0100023 +xref: FMA:9869 +xref: GAID:569 +xref: galen:Pericardium +xref: MA:0000099 +xref: MAT:0000454 +xref: MESH:D010496 +xref: NCIT:C13005 +xref: RETIRED_EHDAA2:0001443 +xref: SCTID:181295003 +xref: VHOG:0001280 +xref: Wikipedia:Pericardium +xref: XAO:0004182 +xref: ZFA:0000054 is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0015410 ! part of heart plus pericardium relationship: BFO:0000051 UBERON:0002359 ! has part fibrous pericardium relationship: BFO:0000051 UBERON:0002406 ! has part pericardial sac relationship: RO:0002221 UBERON:0002349 ! myocardium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002408 name: parietal serous pericardium +def: "Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA:3422 +xref: EHDAA:5378 +xref: EMAPA:19031 +xref: FMA:9870 +xref: MA:0000483 +xref: NCIT:C94500 +xref: SCTID:243956000 +xref: VHOG:0000537 +xref: Wikipedia:Parietal_pericardium is_a: UBERON:0022351 ! parietal serous membrane intersection_of: UBERON:0022351 ! parietal serous membrane intersection_of: BFO:0000050 UBERON:0002357 ! part of serous pericardium @@ -35741,6 +52040,11 @@ relationship: BFO:0000050 UBERON:0002357 ! part of serous pericardium [Term] id: UBERON:0002409 name: pericardial fluid +def: "Transudate contained in the pericardial cavity.[FMA]." [FMA:9887, Wikipedia:Pericardial_fluid] +xref: BTO:0001016 +xref: FMA:9887 +xref: MA:0002530 +xref: Wikipedia:Pericardial_fluid is_a: UBERON:0007794 ! secretion of serous gland is_a: UBERON:0036217 ! coelomic fluid intersection_of: UBERON:0000463 ! organism substance @@ -35751,32 +52055,173 @@ relationship: RO:0003001 UBERON:0002425 ! produced by visceral serous pericardiu [Term] id: UBERON:0002410 name: autonomic nervous system +def: "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." [GO:0048483] +xref: AAO:0000033 +xref: BIRNLEX:1123 +xref: BTO:0002507 +xref: CALOHA:TS-2001 +xref: EHDA:10095 +xref: EHDAA2:0000158 +xref: EHDAA:3767 +xref: EMAPA:16984 +xref: FMA:65553 +xref: GAID:706 +xref: MA:0000219 +xref: MESH:D001341 +xref: NCIT:C12673 +xref: neuronames:2054 +xref: SCTID:362481007 +xref: TAO:0001574 +xref: VHOG:0000396 +xref: Wikipedia:Autonomic_nervous_system +xref: ZFA:0001574 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002433 UBERON:0001016 ! nervous system +[Term] +id: UBERON:0002412 +name: vertebra +def: "The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, http://orcid.org/0000-0002-6601-2165, VSAO:0000184] +xref: AAO:0000691 +xref: CALOHA:TS-2352 +xref: EFO:0001371 +xref: EMAPA:32740 +xref: FMA:9914 +xref: galen:Vertebra +xref: MA:0000309 +xref: NCIT:C12933 +xref: SCTID:181817002 +xref: TAO:0001189 +xref: Wikipedia:Vertebra +xref: XAO:0004019 +xref: ZFA:0001189 +is_a: UBERON:0002513 ! endochondral bone +is_a: UBERON:0008001 ! irregular bone +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: RO:0002473 UBERON:0002481 ! bone tissue +relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column +relationship: RO:0002202 UBERON:0011094 ! vertebra cartilage element + +[Term] +id: UBERON:0002413 +name: cervical vertebra +def: "A vertebra that is located in the cervical region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:17674 +xref: FMA:9915 +xref: GAID:235 +xref: galen:CervicalVertebra +xref: MA:0000311 +xref: MESH:D002574 +xref: NCIT:C12693 +xref: SCTID:181820005 +xref: Wikipedia:Cervical_vertebrae +xref: XAO:0003076 +is_a: UBERON:0003458 ! neck bone +is_a: UBERON:0004247 ! bone of dorsum +is_a: UBERON:0004451 ! trunk or cervical vertebra +is_a: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002481 ! bone tissue +relationship: RO:0002202 UBERON:0013505 ! cervical vertebra cartilage element + +[Term] +id: UBERON:0002415 +name: tail +def: "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail." [AEO:0000109, Wikipedia:Tail] +xref: AEO:0000109 +xref: BILA:0000117 +xref: BTO:0001348 +xref: EFO:0000963 +xref: EHDAA:9198 +xref: GAID:1245 +xref: MAT:0000094 +xref: MESH:D013623 +xref: MIAA:0000094 +xref: WBbt:0005741 +xref: Wikipedia:Tail +is_a: UBERON:0011676 ! subdivision of organism along main body axis +relationship: BFO:0000050 UBERON:0000154 ! part of posterior region of body +relationship: RO:0002160 NCBITaxon:33213 ! Bilateria + [Term] id: UBERON:0002416 name: integumental system +def: "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle." [CARO:0002001, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/29] +xref: AEO:0000154 +xref: BILA:0000118 +xref: CALOHA:TS-1299 +xref: CARO:0002001 +xref: EFO:0000807 +xref: EHDAA2:0000836 +xref: EHDAA2_RETIRED:0003154 +xref: EHDAA:6520 +xref: EMAPA:17524 +xref: EV:0100151 +xref: FMA:72979 +xref: galen:Surface +xref: HAO:0000421 +xref: MA:0000014 +xref: MAT:0000033 +xref: MESH:D034582 +xref: MIAA:0000033 +xref: NCIT:C12907 +xref: SCTID:361692004 +xref: TADS:0000108 +xref: VHOG:0000403 +xref: Wikipedia:Integumentary_system +xref: XAO:0000176 is_a: UBERON:0000467 ! anatomical system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 UBERON:0007376 ! has part outer epithelium relationship: RO:0002007 UBERON:0000468 ! bounding layer of multicellular organism relationship: RO:0002219 UBERON:0013514 ! space surrounding organism relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002417 name: abdominal segment of trunk +def: "The abdominal segment of the torso." [Wikipedia:Lumbar] +xref: EMAPA:35104 +xref: FMA:259211 +xref: MA:0000021 +xref: SCTID:362875007 +xref: Wikipedia:Lumbar is_a: UBERON:0009569 ! subdivision of trunk is_a: UBERON:0011676 ! subdivision of organism along main body axis [Term] id: UBERON:0002418 name: cartilage tissue +def: "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/37, https://sourceforge.net/p/obo/vertebrate-skeletal-anatomy-vsao-term-requests/5, PSPUB:0000170, VSAO:0000040] +comment: Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W] +xref: AAO:0000060 +xref: AEO:0000087 +xref: BTO:0000206 +xref: EFO:0000949 +xref: EHDAA2:0003087 +xref: EMAPA:32730 +xref: EV:0100141 +xref: FMA:37377 +xref: GAID:99 +xref: galen:Cartilage +xref: MA:0000104 +xref: MAT:0000189 +xref: MESH:D002356 +xref: MIAA:0000189 +xref: NCIT:C12373 +xref: NCIT:C32268 +xref: SCTID:309312004 +xref: TAO:0001501 +xref: VHOG:0001207 +xref: VSAO:0000040 +xref: Wikipedia:Cartilage +xref: XAO:0000170 +xref: ZFA:0005622 is_a: UBERON:0004755 ! skeletal tissue relationship: BFO:0000051 CHEBI:18085 ! has part relationship: BFO:0000051 CL:0000138 ! has part chondrocyte @@ -35786,6 +52231,11 @@ relationship: RO:0002433 UBERON:0001434 ! skeletal system [Term] id: UBERON:0002419 name: skin gland +def: "A gland that is part of a skin of body [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35774 +xref: FMA:71878 +xref: MA:0000146 +xref: SCTID:110485007 is_a: UBERON:0003297 ! gland of integumental system is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0006003 ! integumentary adnexa @@ -35793,9 +52243,54 @@ intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000050 UBERON:0002097 ! part of skin of body +[Term] +id: UBERON:0002423 +name: hepatobiliary system +def: "The part of the digestive system that contains the liver and the biliary system." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0011056 +xref: CALOHA:TS-1308 +xref: EFO:0000800 +xref: EHDAA2:0000998 +xref: EHDAA:2189 +xref: EMAPA:16840 +xref: EV:0100088 +xref: MA:0000324 +xref: MAT:0000024 +xref: MIAA:0000024 +xref: NCIT:C43612 +xref: TAO:0000036 +xref: VHOG:0000294 +xref: Wikipedia:Hepatobiliary_system +xref: XAO:0000132 +xref: ZFA:0000036 +is_a: UBERON:0011216 ! organ system subdivision +disjoint_from: UBERON:0004456 ! entire sense organ system +disjoint_from: UBERON:8450002 ! excretory system +relationship: BFO:0000050 UBERON:0001007 ! part of digestive system +relationship: BFO:0000051 UBERON:0002107 ! has part liver +relationship: BFO:0000051 UBERON:0002294 ! has part biliary system +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002215 GO:0061007 ! capable of hepaticobiliary system process +relationship: RO:0002492 UBERON:0000066 ! fully formed stage + [Term] id: UBERON:0002424 name: oral epithelium +def: "An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0010357 +xref: BTO:0001775 +xref: CALOHA:TS-0715 +xref: EHDAA2:0001325 +xref: EHDAA:2187 +xref: EMAPA:16839 +xref: EMAPA:26942 +xref: FMA:265152 +xref: MA:0000344 +xref: NCIT:C49595 +xref: TAO:0000816 +xref: VHOG:0000187 +xref: XAO:0003201 +xref: ZFA:0000816 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium @@ -35806,6 +52301,13 @@ relationship: RO:0002220 UBERON:0000167 ! adjacent to oral cavity [Term] id: UBERON:0002425 name: visceral serous pericardium +def: "Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]." [Wikipedia:Visceral_pericardium] +xref: EMAPA:19032 +xref: FMA:84882 +xref: MA:0000484 +xref: SCTID:243955001 +xref: VHOG:0000538 +xref: Wikipedia:Visceral_pericardium is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0022350 ! visceral serous membrane intersection_of: BFO:0000050 UBERON:0002357 ! part of serous pericardium @@ -35817,6 +52319,11 @@ relationship: RO:0002433 UBERON:0002407 ! pericardium [Term] id: UBERON:0002443 name: choroidal blood vessel +def: "A blood vessel that is part of a choroid [Automatically generated definition]." [OBOL:automatic] +comment: cannot find singular in FMA, using Set class +xref: EMAPA:17828 +xref: FMA:76550 +xref: MA:0001237 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001981 ! blood vessel @@ -35826,20 +52333,63 @@ relationship: BFO:0000050 UBERON:0001776 ! part of optic choroid [Term] id: UBERON:0002457 name: intersomitic artery +def: "The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries." [MP:0010662] +xref: EHDAA2:0000882 +xref: EHDAA:4340 +xref: EMAPA:17616 +xref: MA:0001985 +xref: SCTID:360401001 +xref: TAO:0001061 +xref: VHOG:0000225 +xref: XAO:0004165 +xref: ZFA:0001061 is_a: UBERON:0001637 ! artery is_a: UBERON:0014907 ! intersomitic vessel [Term] id: UBERON:0002458 name: spinal artery +def: "Arteries that supply the spinal cord." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Spinal_artery] +xref: EHDAA2:0001890 +xref: EHDAA:4355 +xref: EMAPA:18241 +xref: MA:0002043 +xref: NCIT:C33587 +xref: SCTID:244228006 +xref: TAO:0000682 +xref: Wikipedia:Spinal_artery +xref: ZFA:0000682 is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0002240 ! spinal cord relationship: RO:0002178 UBERON:0002240 ! spinal cord +[Term] +id: UBERON:0002466 +name: intestine secretion +def: "Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine." [Wikipedia:Succus_entericus] +xref: BTO:0000644 +xref: FMA:62974 +xref: GAID:1162 +xref: MA:0002515 +xref: MESH:D007419 +xref: NCIT:C32875 +xref: Wikipedia:Succus_entericus +is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: RO:0003001 UBERON:0000160 ! produced by intestine +relationship: RO:0003001 UBERON:0000160 ! produced by intestine + [Term] id: UBERON:0002469 name: esophagus mucosa +def: "A mucosa that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0002859 +xref: EMAPA:26981 +xref: FMA:62996 +xref: MA:0002680 +xref: NCIT:C32538 +xref: SCTID:362127004 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -35848,6 +52398,18 @@ relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus [Term] id: UBERON:0002481 name: bone tissue +def: "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000047] +xref: CALOHA:TS-2011 +xref: EMAPA:35179 +xref: FMA:224804 +xref: galen:BoneTissue +xref: MA:0002780 +xref: MESH:D001842 +xref: NCIT:C13076 +xref: VSAO:0000047 +xref: Wikipedia:Bone_tissue +xref: XAO:0004040 +xref: ZFA:0005621 is_a: UBERON:0004755 ! skeletal tissue disjoint_from: UBERON:0005090 ! muscle structure relationship: BFO:0000050 UBERON:0001474 ! part of bone element @@ -35856,6 +52418,10 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0002506 name: iris epithelium +def: "An epithelium that is part of a iris [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35447 +xref: FMA:58517 +xref: MA:0002826 is_a: UBERON:0000488 ! atypical epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium @@ -35863,11 +52429,34 @@ intersection_of: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000051 GO:0048770 ! has part pigment granule relationship: RO:0002433 UBERON:0001769 ! iris -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002511 +name: trabecula carnea +def: "The supporting bundles of muscular fibers lining the walls of the ventricles of the heart." [MGI:monikat, MP:0004067] +xref: EMAPA:18626 +xref: FMA:7269 +xref: MA:0002831 +xref: SCTID:118755002 +xref: Wikipedia:Trabeculae_carneae +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle +relationship: RO:0002473 UBERON:0001133 ! cardiac muscle tissue [Term] id: UBERON:0002513 name: endochondral bone +def: "Replacement bone that forms within cartilage." [GO:0001958, GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/54, VSAO:0000145] +xref: AAO:0010776 +xref: AEO:0000083 +xref: BTO:0002157 +xref: EHDAA2:0003083 +xref: FMA:24321 +xref: TAO:0001591 +xref: VSAO:0000145 +xref: XAO:0004018 +xref: ZFA:0001591 is_a: UBERON:0001474 ! bone element is_a: UBERON:0010363 ! endochondral element intersection_of: UBERON:0001474 ! bone element @@ -35879,13 +52468,43 @@ relationship: RO:0002285 UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0002514 name: intramembranous bone +def: "Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]." [GO:0001957, https://github.com/obophenotype/uberon/issues/267, Wikipedia:Intramembranous_ossification] +xref: EMAPA:36615 +xref: TAO:0001644 +xref: Wikipedia:Intramembranous_ossification +xref: ZFA:0001635 is_a: UBERON:0001474 ! bone element relationship: RO:0002202 UBERON:0003104 ! mesenchyme relationship: RO:0002353 GO:0001957 ! output of intramembranous ossification +[Term] +id: UBERON:0002517 +name: basicranium +def: "The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof." [Wikipedia:Base_of_skull] +comment: The skull base is formed from a series of cartilages either side of, and rostral to, the notochord, whose tip lies just caudal to the pituitary gland. It is closely associated with the sensory capsules, which partially or completely sur- round the olfactory epithelium, the eye, and the inner ear[PMID:11523816] +xref: FMA:52801 +xref: MA:0002840 +xref: MESH:D019291 +xref: MFMO:0000044 +xref: NCIT:C12493 +xref: SCTID:181890004 +xref: Wikipedia:Base_of_skull +is_a: UBERON:0000075 ! subdivision of skeletal system +relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium +relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium +relationship: RO:0002433 UBERON:0003128 ! cranium + [Term] id: UBERON:0002521 name: elastic tissue +def: "Connective tissue composed of elastic fibers." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:20113 +xref: GAID:926 +xref: MA:0002853 +xref: MESH:D004547 +xref: NCIT:C32495 +xref: SCTID:27197004 +xref: Wikipedia:Elastic_fiber is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002473 GO:0071953 ! elastic fiber @@ -35895,6 +52514,17 @@ relationship: RO:0002473 GO:0071953 ! elastic fiber [Term] id: UBERON:0002522 name: tunica media +def: "The middle layer of an artery or vein. [WP,unvetted]." [Wikipedia:Tunica_media] +comment: May be composed of smooth muscle and elastic tissue +xref: BTO:0002011 +xref: EMAPA:36298 +xref: FMA:55590 +xref: GAID:170 +xref: MA:0002855 +xref: MESH:D017540 +xref: NCIT:C33821 +xref: SCTID:61695000 +xref: Wikipedia:Tunica_media is_a: UBERON:0004797 ! blood vessel layer relationship: BFO:0000051 UBERON:0002521 ! has part elastic tissue relationship: BFO:0000051 UBERON:0004237 ! has part blood vessel smooth muscle @@ -35903,6 +52533,17 @@ relationship: RO:0002219 UBERON:0005734 ! tunica adventitia of blood vessel [Term] id: UBERON:0002523 name: tunica intima +def: "The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]." [ISBN:0073040584, NCIT:C33820, Wikipedia:Tunica_intima] +xref: BTO:0002012 +xref: EMAPA:36297 +xref: FMA:55589 +xref: GAID:523 +xref: MA:0002861 +xref: MESH:D017539 +xref: NCIT:C33820 +xref: SCTID:8361002 +xref: SCTID:87483006 +xref: Wikipedia:Tunica_intima is_a: UBERON:0004923 ! organ component layer relationship: BFO:0000051 UBERON:0001986 ! has part endothelium relationship: RO:0002219 UBERON:0002522 ! tunica media @@ -35911,6 +52552,25 @@ relationship: RO:0002220 UBERON:0010161 ! adjacent to lumen of blood vessel [Term] id: UBERON:0002530 name: gland +def: "An organ that functions as a secretory or excretory organ." [MGI:csmith, MP:0002163] +xref: AAO:0000212 +xref: AEO:0000096 +xref: BTO:0000522 +xref: EFO:0000797 +xref: EHDAA2:0003096 +xref: EHDAA:2161 +xref: EMAPA:18425 +xref: FMA:7146 +xref: FMA:86294 +xref: galen:Gland +xref: HAO:0000375 +xref: MA:0003038 +xref: MAT:0000021 +xref: MIAA:0000021 +xref: NCIT:C13319 +xref: SCTID:134358001 +xref: Wikipedia:Gland +xref: WikipediaCategory:Glands is_a: UBERON:0000062 ! organ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa relationship: RO:0002215 GO:0046903 ! capable of secretion @@ -35919,12 +52579,46 @@ relationship: RO:0003000 UBERON:0000463 ! produces organism substance [Term] id: UBERON:0002532 name: epiblast (generic) +def: "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]." [Wikipedia:Epiblast, ZFIN:curator] +xref: BTO:0004593 +xref: FMA:296704 +xref: MAT:0000067 +xref: MIAA:0000067 +xref: VHOG:0000243 +xref: Wikipedia:Epiblast is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000051 CL:0000352 ! has part epiblast cell +[Term] +id: UBERON:0002533 +name: post-anal tail bud +def: "The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node." [BTO:0001445] +xref: AAO:0011104 +xref: BTO:0001445 +xref: EFO:0002748 +xref: EHDAA2:0001976 +xref: EHDAA:1595 +xref: EMAPA:16580 +xref: MAT:0000070 +xref: MIAA:0000070 +xref: TAO:0000077 +xref: VHOG:0000201 +xref: XAO:0000107 +xref: ZFA:0000077 +is_a: UBERON:0002050 ! embryonic structure +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata + [Term] id: UBERON:0002536 name: arthropod sensillum +def: "Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt]." [FBbt:00007152, Wikipedia:Sensillum] +xref: BTO:0001237 +xref: EFO:0000939 +xref: HAO:0000933 +xref: MAT:0000163 +xref: MIAA:0000163 +xref: TGMA:0000540 +xref: Wikipedia:Sensillum is_a: UBERON:0000020 ! sense organ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002160 NCBITaxon:6656 ! Arthropoda @@ -35932,6 +52626,24 @@ relationship: RO:0002160 NCBITaxon:6656 ! Arthropoda [Term] id: UBERON:0002539 name: pharyngeal arch +def: "One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches." [http://orcid.org/0000-0002-6601-2165, PMID:16313389, ZFA:yb] +xref: AAO:0010359 +xref: BTO:0001785 +xref: EFO:0000959 +xref: EHDAA:571 +xref: EMAPA:16117 +xref: FMA:293015 +xref: GAID:1292 +xref: MAT:0000242 +xref: MESH:D001934 +xref: MIAA:0000242 +xref: NCIT:C34249 +xref: SCTID:308766004 +xref: TAO:0001306 +xref: VHOG:0000155 +xref: Wikipedia:Pharyngeal_arch +xref: XAO:0000096 +xref: ZFA:0001306 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0010188 ! protuberance is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -35943,6 +52655,12 @@ relationship: RO:0002256 UBERON:0007690 ! early pharyngeal endoderm [Term] id: UBERON:0002546 name: cranial placode +def: "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic." [http://www.ncbi.nlm.nih.gov/books/NBK53175/, https://github.com/obophenotype/uberon/issues/135, https://github.com/seger/aao/issues/4, https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/p/obo/xenopus-anatomy-xao-term-requests/11/] +xref: AAO:0010466 +xref: EFO:0001650 +xref: MAT:0000369 +xref: MIAA:0000369 +xref: XAO:0000305 is_a: UBERON:0005085 ! ectodermal placode relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -35950,12 +52668,43 @@ relationship: RO:0002160 NCBITaxon:7711 ! Chordata [Term] id: UBERON:0002553 name: anatomical cavity +def: "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina." [FMA:67552] +xref: BIRNLEX:1011 +xref: FMA:67552 +xref: galen:Cavity +xref: MA:0002447 +xref: NCIT:C34007 is_a: UBERON:0000464 ! anatomical space relationship: RO:0001015 UBERON:0000463 ! organism substance +[Term] +id: UBERON:0002558 +name: organ cavity +xref: BIRNLEX:1019 +xref: FMA:12237 +xref: SCTID:362606005 +is_a: UBERON:0002553 ! anatomical cavity + +[Term] +id: UBERON:0002561 +name: lumen of central nervous system +def: "The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube." [https://orcid.org/0000-0002-6601-2165] +xref: BIRNLEX:1029 +xref: FMA:75007 +is_a: UBERON:0002558 ! organ cavity +intersection_of: UBERON:0002558 ! organ cavity +intersection_of: RO:0002572 UBERON:0001017 ! central nervous system +relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system +relationship: RO:0002572 UBERON:0001017 ! central nervous system + [Term] id: UBERON:0002616 name: regional part of brain +def: "Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia." [BIRNLEX:1167] +xref: BIRNLEX:1167 +xref: FMA:55676 +xref: NCIT:C13031 +xref: SCTID:384763002 is_a: UBERON:0000073 ! regional part of nervous system is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000481 ! multi-tissue structure @@ -35966,16 +52715,36 @@ relationship: RO:0002473 UBERON:0003714 ! neural tissue [Term] id: UBERON:0002726 name: cervical spinal cord +def: "A spinal cord segment that adjacent_to a cervical region." [OBOL:automatic] +xref: BIRNLEX:1499 +xref: FMA:71166 +xref: MA:0003081 +xref: NCIT:C12892 +xref: neuronames:1654 +xref: SCTID:180960003 is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: RO:0002220 UBERON:0005434 ! adjacent to cervical region relationship: RO:0002160 NCBITaxon:8287 ! Sarcopterygii relationship: RO:0002220 UBERON:0005434 ! adjacent to cervical region -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002925 name: trigeminal nucleus +def: "A nucleus of brain that is part of a trigeminal nuclear complex." [OBOL:automatic] +xref: BM:V +xref: BTO:0001074 +xref: CALOHA:TS-2077 +xref: EMAPA:35883 +xref: EV:0100271 +xref: FMA:71247 +xref: GAID:604 +xref: http://uri.neuinfo.org/nif/nifstd/nifext_11 +xref: MA:0001028 +xref: MESH:D014278 +xref: NCIT:C12807 +xref: SCTID:280164007 +xref: VHOG:0001353 is_a: UBERON:0000126 ! cranial nerve nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0007641 ! part of trigeminal nuclear complex @@ -35985,6 +52754,14 @@ relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve [Term] id: UBERON:0003023 name: pontine tegmentum +def: "Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133)." [BIRNLEX:923] +xref: BAMS:PTg +xref: BIRNLEX:923 +xref: DHBA:12416 +xref: FMA:71108 +xref: HBA:9135 +xref: SCTID:362401009 +xref: Wikipedia:Pontine_tegmentum is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0000988 ! part of pons @@ -35992,26 +52769,49 @@ relationship: BFO:0000051 UBERON:0002047 ! has part pontine raphe nucleus relationship: BFO:0000051 UBERON:0002128 ! has part superior olivary complex relationship: BFO:0000051 UBERON:0002148 ! has part locus ceruleus relationship: BFO:0000051 UBERON:0002149 ! has part superior salivatory nucleus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003037 name: septum +def: "A wall, dividing a cavity or structure into smaller ones[WP]." [Wikipedia:Septum] +comment: general anatomical term in FMA +xref: AAO:0011127 +xref: FMA:86461 +xref: Wikipedia:Septum is_a: UBERON:0000061 ! anatomical structure relationship: RO:0001025 UBERON:0002553 ! anatomical cavity [Term] id: UBERON:0003038 name: thoracic spinal cord +def: "The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]." [Wikipedia:Thoracic_spinal_cord] +xref: BIRNLEX:966 +xref: FMA:71167 +xref: MA:0003082 +xref: NCIT:C12894 +xref: neuronames:1718 +xref: SCTID:278750009 +xref: Wikipedia:Thoracic_spinal_cord is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of trunk -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003052 name: midbrain-hindbrain boundary +def: "The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate." [GO:0021555] +xref: AAO:0011064 +xref: DMBA:16810 +xref: EHDAA2:0004395 +xref: EHDAA:5789 +xref: EMAPA:32857 +xref: NCIT:C93172 +xref: neuronames:2076 +xref: TAO:0000042 +xref: VHOG:0000649 +xref: XAO:0000016 +xref: ZFA:0000042 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction @@ -36025,6 +52825,15 @@ relationship: RO:0002495 UBERON:0009615 ! midbrain hindbrain boundary neural pla [Term] id: UBERON:0003055 name: periderm +def: "The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm." [ISBN:9780878932504, PMID:25133425, PMID:35582825] +xref: EHDAA2:0001846 +xref: EHDAA:6538 +xref: FMA:295662 +xref: NCIT:C34247 +xref: TAO:0001185 +xref: VHOG:0001680 +xref: XAO:0000029 +xref: ZFA:0001185 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0007376 ! outer epithelium is_a: UBERON:3000961 ! external integument structure @@ -36032,6 +52841,12 @@ is_a: UBERON:3000961 ! external integument structure [Term] id: UBERON:0003056 name: pre-chordal neural plate +def: "The portion of neural plate anterior to the mid-hindbrain junction." [XB:curator] +xref: AAO:0011084 +xref: TAO:0007016 +xref: VHOG:0001200 +xref: XAO:0000045 +xref: ZFA:0007016 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0003075 ! part of neural plate @@ -36040,6 +52855,11 @@ relationship: BSPO:0000096 UBERON:0009615 ! midbrain hindbrain boundary neural p [Term] id: UBERON:0003057 name: chordal neural plate +def: "The portion of neural plate posterior to the mid-hindbrain junction." [XB:curator] +xref: TAO:0007017 +xref: VHOG:0001201 +xref: XAO:0000046 +xref: ZFA:0007017 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003075 ! part of neural plate relationship: BSPO:0000099 UBERON:0009615 ! midbrain hindbrain boundary neural plate @@ -36047,6 +52867,15 @@ relationship: BSPO:0000099 UBERON:0009615 ! midbrain hindbrain boundary neural p [Term] id: UBERON:0003059 name: presomitic mesoderm +def: "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form." [ZFIN:curator] +xref: AAO:0011086 +xref: EFO:0001982 +xref: EMAPA:16189 +xref: EMAPA:16752 +xref: TAO:0000279 +xref: VHOG:0000559 +xref: XAO:0000057 +xref: ZFA:0000279 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: RO:0002387 UBERON:0002329 ! somite @@ -36058,6 +52887,17 @@ relationship: RO:0002495 UBERON:0007282 ! presumptive segmental plate [Term] id: UBERON:0003061 name: blood island +def: "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]." [Wikipedia:Blood_island_of_umbilical_vesicle] +xref: AAO:0011006 +xref: EFO:0003489 +xref: EHDAA:207 +xref: NCIT:C34113 +xref: TAO:0000094 +xref: TE:E5.11.2.0.0.0.4 +xref: VHOG:0000085 +xref: Wikipedia:Blood_island_of_umbilical_vesicle +xref: XAO:0000067 +xref: ZFA:0000094 is_a: UBERON:0006598 ! presumptive structure relationship: RO:0002202 UBERON:0003081 ! lateral plate mesoderm relationship: RO:0002387 UBERON:0002390 ! hematopoietic system @@ -36065,6 +52905,16 @@ relationship: RO:0002387 UBERON:0002390 ! hematopoietic system [Term] id: UBERON:0003063 name: prechordal plate +def: "A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue." [ISBN:0838580343, MP:0004387] +xref: AAO:0011085 +xref: EHDAA2:0001493 +xref: EHDAA:181 +xref: FMA:295532 +xref: TAO:0000060 +xref: VHOG:0000086 +xref: Wikipedia:Prechordal_plate +xref: XAO:0000079 +xref: ZFA:0000060 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003068 ! part of axial mesoderm relationship: RO:0002494 UBERON:0034878 ! prechordal mesoderm @@ -36072,6 +52922,18 @@ relationship: RO:0002494 UBERON:0034878 ! prechordal mesoderm [Term] id: UBERON:0003064 name: intermediate mesoderm +def: "The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:curators, Wikipedia:Intermediate_mesoderm] +xref: AAO:0010575 +xref: EMAPA:16056 +xref: EMAPA:16178 +xref: FMA:293147 +xref: NCIT:C34193 +xref: SCTID:361476001 +xref: TAO:0001206 +xref: VHOG:0000087 +xref: Wikipedia:Intermediate_mesoderm +xref: XAO:0000085 +xref: ZFA:0001206 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm relationship: BFO:0000050 UBERON:0005256 ! part of trunk mesenchyme @@ -36082,12 +52944,26 @@ relationship: RO:0002220 UBERON:0003081 ! adjacent to lateral plate mesoderm [Term] id: UBERON:0003067 name: dorsolateral placode +def: "Lateral neurogenic placodes positioned dorsal of the epibranchial placodes." [ZFIN:curator] +comment: The only remaining dorsolateral placode in land vertebrates is the otic/octaval placode +xref: TAO:0001310 +xref: VHOG:0000103 +xref: XAO:0000187 +xref: ZFA:0001310 is_a: UBERON:0009955 ! neurogenic placode relationship: BSPO:0000098 UBERON:0003078 ! epibranchial placode [Term] id: UBERON:0003068 name: axial mesoderm +def: "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GO:0048318, Wikipedia:Chordamesoderm] +xref: AAO:0011017 +xref: EFO:0003647 +xref: TAO:0001204 +xref: VHOG:0000107 +xref: Wikipedia:Chordamesoderm +xref: XAO:0000205 +xref: ZFA:0001204 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -36096,12 +52972,27 @@ relationship: RO:0002202 UBERON:0000926 ! mesoderm [Term] id: UBERON:0003070 name: trigeminal placode complex +def: "A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/693, PMID:22512454] +xref: EFO:0003433 +xref: EHDAA2:0004209 +xref: TAO:0000162 +xref: VHOG:0000109 +xref: XAO:0000225 +xref: ZFA:0000162 is_a: UBERON:0003067 ! dorsolateral placode relationship: RO:0002385 UBERON:0003942 ! somatosensory system [Term] id: UBERON:0003071 name: eye primordium +def: "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles." [GO:0046619, ZFA:0000570] +xref: AAO:0011038 +xref: EFO:0003541 +xref: EHDAA2:0004431 +xref: TAO:0000570 +xref: XAO:0000227 +xref: XAO:0004090 +xref: ZFA:0000570 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0001048 ! primordium is_a: UBERON:0005291 ! embryonic tissue @@ -36116,6 +53007,16 @@ relationship: RO:0002387 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0003072 name: optic cup +def: "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]." [MP:0004269, Wikipedia:Optic_cup_(embryology), ZFA:0001202] +xref: BTO:0005351 +xref: EHDAA2:0001303 +xref: EHDAA:2912 +xref: EMAPA:16674 +xref: NCIT:C34233 +xref: SCTID:308789007 +xref: TAO:0001202 +xref: VHOG:0000167 +xref: ZFA:0001202 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0010312 ! part of immature eye @@ -36125,6 +53026,19 @@ relationship: RO:0002256 UBERON:0003073 ! lens placode [Term] id: UBERON:0003073 name: lens placode +def: "A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]." [Wikipedia:Lens_placode, ZFIN:curator] +xref: AAO:0011055 +xref: EFO:0003494 +xref: EHDAA2:0000982 +xref: EHDAA:2908 +xref: EMAPA:16672 +xref: FMA:296767 +xref: NCIT:C34202 +xref: TAO:0000122 +xref: VHOG:0000166 +xref: Wikipedia:Lens_placode +xref: XAO:0000240 +xref: ZFA:0000122 is_a: UBERON:0002546 ! cranial placode is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0010312 ! immature eye @@ -36138,6 +53052,23 @@ relationship: RO:0002387 UBERON:0000965 ! lens of camera-type eye [Term] id: UBERON:0003075 name: neural plate +def: "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]." [ISBN:0815318960, OMD:neural+plate, Wikipedia:Neural_plate, ZFIN:curator] +xref: AAO:0011072 +xref: BTO:0001765 +xref: DHBA:10153 +xref: DMBA:15565 +xref: EHDAA:346 +xref: EHDAA:902 +xref: EMAPA:35593 +xref: FMA:293879 +xref: NCIT:C34225 +xref: neuronames:1362 +xref: RETIRED_EHDAA2:0001252 +xref: TAO:0000132 +xref: VHOG:0000068 +xref: Wikipedia:Neural_plate +xref: XAO:0000249 +xref: ZFA:0000132 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0016879 ! future central nervous system @@ -36148,6 +53079,11 @@ relationship: RO:0002495 UBERON:0007284 ! presumptive neural plate [Term] id: UBERON:0003076 name: posterior neural tube +xref: AAO:0011082 +xref: TAO:0007037 +xref: VHOG:0001383 +xref: XAO:0000250 +xref: ZFA:0007037 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: RO:0002202 UBERON:0003057 ! chordal neural plate @@ -36155,6 +53091,19 @@ relationship: RO:0002202 UBERON:0003057 ! chordal neural plate [Term] id: UBERON:0003077 name: paraxial mesoderm +def: "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]." [GO:0048339, https://github.com/obophenotype/uberon/issues/30] +xref: AAO:0010568 +xref: EFO:0003515 +xref: EMAPA:16183 +xref: EMAPA:16751 +xref: FMA:293145 +xref: NCIT:C34244 +xref: SCTID:361475002 +xref: TAO:0000255 +xref: VHOG:0000114 +xref: Wikipedia:Paraxial_mesoderm +xref: XAO:0000259 +xref: ZFA:0000255 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0015212 ! lateral structure @@ -36165,6 +53114,14 @@ relationship: RO:0002495 UBERON:0007285 ! presumptive paraxial mesoderm [Term] id: UBERON:0003078 name: epibranchial placode +def: "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia." [VHOG:0000117] +xref: AAO:0011036 +xref: EFO:0003455 +xref: FMA:293968 +xref: TAO:0001294 +xref: VHOG:0000117 +xref: XAO:0000284 +xref: ZFA:0001294 is_a: UBERON:0009955 ! neurogenic placode relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system relationship: RO:0002202 UBERON:0000076 ! external ectoderm @@ -36173,6 +53130,11 @@ relationship: RO:0002385 UBERON:0002410 ! autonomic nervous system [Term] id: UBERON:0003080 name: anterior neural tube +xref: AAO:0011012 +xref: TAO:0007038 +xref: VHOG:0001384 +xref: XAO:0000307 +xref: ZFA:0007038 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: RO:0002202 UBERON:0003056 ! pre-chordal neural plate @@ -36180,6 +53142,19 @@ relationship: RO:0002202 UBERON:0003056 ! pre-chordal neural plate [Term] id: UBERON:0003081 name: lateral plate mesoderm +def: "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]." [MP:0010117, Wikipedia:Lateral_plate_mesoderm] +xref: AAO:0010574 +xref: EHDAA2:0000919 +xref: EHDAA:379 +xref: EMAPA:16179 +xref: FMA:293149 +xref: NCIT:C34199 +xref: SCTID:361477005 +xref: TAO:0000121 +xref: VHOG:0000118 +xref: Wikipedia:Lateral_plate_mesoderm +xref: XAO:0000311 +xref: ZFA:0000121 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -36191,6 +53166,24 @@ relationship: RO:0002221 UBERON:0003887 ! intraembryonic coelom [Term] id: UBERON:0003082 name: myotome +def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells." [AEO:0001018] +xref: AAO:0011067 +xref: AEO:0001018 +xref: BTO:0000742 +xref: EHDAA2_RETIRED:0003431 +xref: EHDAA:1721 +xref: EHDAA:1727 +xref: EHDAA:1733 +xref: EHDAA:1739 +xref: EMAPA:32841 +xref: FMA:295658 +xref: NCIT:C34214 +xref: SCTID:344535001 +xref: TAO:0001056 +xref: VHOG:0001244 +xref: Wikipedia:Myotome +xref: XAO:0000315 +xref: ZFA:0001056 is_a: UBERON:0017650 ! developing mesenchymal structure relationship: RO:0002202 UBERON:0004290 ! dermomyotome relationship: RO:0002433 UBERON:0001630 ! muscle organ @@ -36198,6 +53191,15 @@ relationship: RO:0002433 UBERON:0001630 ! muscle organ [Term] id: UBERON:0003083 name: trunk neural crest +def: "Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]." [ISBN:0815318960, Wikipedia:Trunk_neural_crest] +xref: AAO:0010582 +xref: EFO:0003605 +xref: EHDAA2:0001901 +xref: TAO:0001024 +xref: VHOG:0000062 +xref: Wikipedia:Trunk_neural_crest +xref: XAO:0000319 +xref: ZFA:0001024 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -36207,15 +53209,53 @@ relationship: BFO:0000051 CL:0000011 ! has part migratory trunk neural crest cel [Term] id: UBERON:0003084 name: heart primordium +def: "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone." [ZFIN:curator] +xref: AAO:0011044 +xref: BTO:0001887 +xref: NCIT:C34276 +xref: TAO:0000028 +xref: XAO:0000336 +xref: ZFA:0000028 is_a: UBERON:0001048 ! primordium relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system relationship: RO:0002202 UBERON:0003081 ! lateral plate mesoderm relationship: RO:0002202 UBERON:0004140 ! primary heart field relationship: RO:0002202 UBERON:0007005 ! cardiogenic splanchnic mesoderm +[Term] +id: UBERON:0003086 +name: caudal artery +def: "Extension of the dorsal aorta in the tail." [Wikipedia:Caudal_artery, ZFIN:curator] +xref: AAO:0011023 +xref: EFO:0003472 +xref: TAO:0000011 +xref: VHOG:0000123 +xref: Wikipedia:Caudal_artery +xref: XAO:0000364 +xref: ZFA:0000011 +is_a: UBERON:0001637 ! artery +is_a: UBERON:0003524 ! tail blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +intersection_of: RO:0002252 UBERON:0005805 ! dorsal aorta +relationship: BFO:0000050 UBERON:2001073 ! part of axial vasculature +relationship: RO:0002252 UBERON:0005805 ! dorsal aorta + [Term] id: UBERON:0003089 name: sclerotome +def: "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]." [https://github.com/obophenotype/uberon/issues/316, Wikipedia:Sclerotome, XB:curator] +xref: AAO:0010571 +xref: AEO:0000212 +xref: EHDAA2:0003439 +xref: EMAPA:31159 +xref: FMA:295652 +xref: NCIT:C34287 +xref: TAO:0001080 +xref: VHOG:0000680 +xref: Wikipedia:Sclerotome +xref: XAO:0000397 +xref: ZFA:0001080 is_a: UBERON:0005856 ! developing mesenchymal condensation is_a: UBERON:0007530 ! migrating mesenchyme population relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -36224,6 +53264,16 @@ relationship: RO:0002202 UBERON:0002329 ! somite [Term] id: UBERON:0003099 name: cranial neural crest +def: "Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage." [MGI:anna] +xref: AAO:0010580 +xref: EFO:0003645 +xref: EHDAA2:0004420 +xref: EMAPA:16091 +xref: TAO:0001194 +xref: VHOG:0000063 +xref: Wikipedia:Cranial_neural_crest +xref: XAO:0001001 +xref: ZFA:0001194 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -36233,22 +53283,69 @@ relationship: BFO:0000051 CL:0000008 ! has part migratory cranial neural crest c [Term] id: UBERON:0003100 name: female organism +def: "Gonochoristic organism that can produce female gametes." [CARO:0000028] +xref: AAO:0010030 +xref: BILA:0000028 +xref: CARO:0000028 +xref: FMA:67812 +xref: HAO:0000028 +xref: SCTID:362608006 +xref: TAO:0000303 +xref: TGMA:0001839 +xref: XAO:0003005 +xref: ZFA:0000303 is_a: UBERON:0000468 ! multicellular organism [Term] id: UBERON:0003102 name: surface structure +def: "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/24] +xref: AAO:0010337 +xref: AEO_RETIRED:0000010 +xref: EHDAA2_RETIRED:0003010 +xref: galen:SurfaceRegion +xref: TAO:0000292 +xref: VSAO:0000001 +xref: Wikipedia:Surface_structure +xref: XAO:0003028 +xref: ZFA:0000292 is_a: UBERON:0000061 ! anatomical structure relationship: RO:0002220 UBERON:0013514 ! adjacent to space surrounding organism [Term] id: UBERON:0003103 name: compound organ +def: "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types." [CARO:0000024] +xref: AAO:0010015 +xref: AEO:0000024 +xref: BILA:0000024 +xref: CARO:0000024 +xref: EHDAA2:0003024 +xref: HAO:0000024 +xref: TADS:0000598 +xref: TAO:0000496 +xref: TGMA:0001837 +xref: VHOG:0001723 +xref: XAO:0003041 +xref: ZFA:0000496 is_a: UBERON:0000062 ! organ [Term] id: UBERON:0003104 name: mesenchyme +def: "Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme." [https://archive.org/details/invertebratesnde00brus/page/n240/mode/2up, https://en.wikipedia.org/wiki/Mesenchyme, https://github.com/obophenotype/uberon/issues/1641] +xref: AAO:0010427 +xref: AEO:0000145 +xref: BTO:0001393 +xref: CALOHA:TS-0620 +xref: EHDAA2:0003145 +xref: EV:0100007 +xref: NCIT:C13301 +xref: TAO:0000393 +xref: VHOG:0000170 +xref: Wikipedia:Mesenchyme +xref: XAO:0003046 +xref: ZFA:0000393 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002473 CL:0008019 ! mesenchymal cell @@ -36257,9 +53354,30 @@ relationship: RO:0002254 UBERON:0000926 {gci_filler="NCBITaxon:7711", gci_relati relationship: RO:0002328 GO:0032502 ! developmental process relationship: RO:0002473 CL:0008019 ! mesenchymal cell +[Term] +id: UBERON:0003112 +name: olfactory region +def: "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ." [TAO:0000351] +xref: AAO:0010206 +xref: EFO:0003525 +xref: NCIT:C98765 +xref: TAO:0000351 +xref: XAO:0003172 +xref: ZFA:0000351 +is_a: UBERON:0034921 ! multi organ part structure +relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium +relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium + [Term] id: UBERON:0003113 name: dermatocranium +def: "Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]." [Wikipedia:Skull_roof, ZFA:0000863] +xref: AAO:0010154 +xref: TAO:0000863 +xref: VHOG:0001665 +xref: Wikipedia:Skull_roof +xref: XAO:0003169 +xref: ZFA:0000863 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system relationship: BFO:0000050 UBERON:0010364 ! part of dermal skeleton relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -36267,16 +53385,47 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0003115 name: pharyngeal arch 4 +def: "Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus." [MP:0006340] +xref: AAO:0010366 +xref: EHDAA2:0000086 +xref: EHDAA:1663 +xref: EMAPA:16760 +xref: FMA:293035 +xref: SCTID:308770007 +xref: TAO:0001599 +xref: VHOG:0000299 +xref: XAO:0000449 +xref: ZFA:0001607 is_a: UBERON:0002539 ! pharyngeal arch [Term] id: UBERON:0003117 name: pharyngeal arch 6 +def: "The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles." [MP:0006347] +xref: AAO:0010368 +xref: EHDAA2:0004075 +xref: EMAPA:32766 +xref: FMA:293047 +xref: SCTID:308772004 +xref: TAO:0001601 +xref: VHOG:0001205 +xref: XAO:0000453 +xref: ZFA:0001609 is_a: UBERON:0002539 ! pharyngeal arch [Term] id: UBERON:0003118 name: pharyngeal arch artery 1 +def: "The vessels formed within the first pair of branchial arches in embryogenesis." [MP:0010355] +xref: AAO:0010415 +xref: EHDAA2:0000007 +xref: EMAPA:16202 +xref: EMAPA:16685 +xref: SCTID:308774003 +xref: TAO:0005005 +xref: VHOG:0000149 +xref: XAO:0000342 +xref: ZFA:0005005 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 @@ -36286,6 +53435,16 @@ relationship: RO:0002433 UBERON:0004362 ! pharyngeal arch 1 [Term] id: UBERON:0003121 name: pharyngeal arch artery 4 +def: "The vessels formed within the fourth pair of branchial arches in embryogenesis." [MP:0006354] +comment: proximal right subclavian +xref: AAO:0010420 +xref: EHDAA2:0000087 +xref: EMAPA:17004 +xref: SCTID:308777005 +xref: TAO:0005008 +xref: Wikipedia:Aortic_arches#Arch_4 +xref: XAO:0000355 +xref: ZFA:0005008 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 @@ -36294,6 +53453,16 @@ relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 [Term] id: UBERON:0003123 name: pharyngeal arch artery 6 +def: "The vessels formed within the sixth pair of branchial arches in embryogenesis." [MP:0006355] +xref: AAO:0010422 +xref: EHDAA2:0000102 +xref: EMAPA:17005 +xref: SCTID:308779008 +xref: TAO:0005016 +xref: VHOG:0000144 +xref: Wikipedia:Aortic_arches#Arch_6 +xref: XAO:0000353 +xref: ZFA:0005016 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 @@ -36302,23 +53471,65 @@ relationship: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 [Term] id: UBERON:0003126 name: trachea +def: "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." [GO:0060438, Wikipedia:Vertebrate_trachea] +xref: AAO:0010140 +xref: BTO:0001388 +xref: CALOHA:TS-1060 +xref: EFO:0000935 +xref: EHDAA2:0002066 +xref: EHDAA:3078 +xref: EMAPA:16853 +xref: EV:0100040 +xref: FMA:7394 +xref: GAID:361 +xref: MA:0000441 +xref: MAT:0000137 +xref: MESH:D014132 +xref: MIAA:0000137 +xref: NCIT:C12428 +xref: SCTID:181213009 +xref: VHOG:0000371 +xref: Wikipedia:Vertebrate_trachea +xref: XAO:0000118 is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: RO:0001025 UBERON:0002224 ! thoracic cavity relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002202 UBERON:0008947 ! respiratory primordium relationship: RO:0002433 UBERON:0001004 ! respiratory system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003128 name: cranium +def: "Upper portion of the skull that excludes the mandible (when present in the organism)." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Cranium_(anatomy)] +xref: BTO:0001328 +xref: EFO:0000831 +xref: EHDAA:6029 +xref: FMA:71325 +xref: MA:0000316 +xref: MAT:0000340 +xref: MIAA:0000340 +xref: SCTID:181889008 +xref: VHOG:0000334 +xref: Wikipedia:Cranium_(anatomy) is_a: UBERON:0000075 ! subdivision of skeletal system -property_value: RO:0002175 NCBITaxon:7762 [Term] id: UBERON:0003129 name: skull +def: "Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]." [http://sourceforge.net/tracker/?func=detail&aid=2962656&group_id=76834&atid=1205376, PMID:11523816, Wikipedia:Skull] +xref: BTO:0001295 +xref: CALOHA:TS-2344 +xref: EHDAA2:0000325 +xref: EMAPA:17680 +xref: FMA:46565 +xref: GAID:82 +xref: galen:Skull +xref: MESH:D012886 +xref: NCIT:C12789 +xref: SCTID:110530005 +xref: Wikipedia:Skull +xref: WikipediaCategory:Skull is_a: UBERON:0000075 ! subdivision of skeletal system is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0000033 ! part of head @@ -36330,6 +53541,13 @@ relationship: RO:0002160 NCBITaxon:89593 ! Craniata [Term] id: UBERON:0003133 name: reproductive organ +def: "An organ involved in reproduction." [UBERON:xp] +xref: MA:0001752 +xref: MESH:D005835 +xref: NCIT:C25177 +xref: SCTID:128181006 +xref: TGMA:0000591 +xref: WBbt:0008422 is_a: UBERON:0000062 ! organ is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000062 ! organ @@ -36339,6 +53557,9 @@ relationship: RO:0002216 GO:0022414 ! capable of part of reproductive process [Term] id: UBERON:0003134 name: female reproductive organ +def: "A female organ involved in reproduction." [UBERON:xp] +xref: EMAPA:28540 +xref: MA:0000544 is_a: UBERON:0003133 ! reproductive organ intersection_of: UBERON:0003133 ! reproductive organ intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism @@ -36347,19 +53568,42 @@ relationship: BFO:0000050 UBERON:0000474 ! part of female reproductive system [Term] id: UBERON:0003215 name: alveolus +def: "Organ part that has the form of a hollow cavity[WP]." [Wikipedia:Alveolus] +xref: EFO:0002513 +xref: FMA:82493 +xref: NCIT:C12986 +xref: Wikipedia:Alveolus is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0003218 name: ovary septum +def: "Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]." [GO:0080126] is_a: UBERON:0003037 ! septum intersection_of: UBERON:0003037 ! septum intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary +[Term] +id: UBERON:0003235 +name: epithelium of upper jaw +def: "An epithelium that is part of a upper jaw [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0002119 +xref: EHDAA:8027 +xref: EMAPA:18971 +is_a: UBERON:0035037 ! jaw epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region + [Term] id: UBERON:0003236 name: epithelium of lower jaw +def: "An epithelium that is part of a lower jaw [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001019 +xref: EHDAA:7999 +xref: EMAPA:35516 +xref: VHOG:0000802 is_a: UBERON:0035037 ! jaw epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region @@ -36368,6 +53612,11 @@ relationship: BFO:0000050 UBERON:0001710 ! part of lower jaw region [Term] id: UBERON:0003257 name: yolk sac endoderm +def: "The portion of the yolk sac that is derived from endoderm and lines the yolk sac." [UBERON:cjm] +xref: EHDAA2:0002215 +xref: EHDAA:166 +xref: EMAPA:16086 +xref: VHOG:0000626 is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0005911 ! endo-epithelium @@ -36379,6 +53628,9 @@ relationship: RO:0002007 UBERON:0001040 ! bounding layer of yolk sac [Term] id: UBERON:0003258 name: endoderm of foregut +def: "An endoderm that is part of a foregut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0004568 +xref: EHDAA:524 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0015833 ! foregut epithelium @@ -36386,18 +53638,81 @@ intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut intersection_of: RO:0002202 UBERON:0000925 ! endoderm +[Term] +id: UBERON:0003259 +name: endoderm of midgut +def: "An endoderm that is part of a midgut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA:987 +xref: EMAPA:16257 +xref: RETIRED_EHDAA2:0001194 +xref: VHOG:0001080 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0003352 ! epithelium of midgut +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000490 ! unilaminar epithelium +intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut +intersection_of: RO:0002202 UBERON:0000925 ! endoderm + +[Term] +id: UBERON:0003260 +name: endoderm of hindgut +def: "An endoderm that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA:979 +xref: RETIRED_EHDAA2:0000781 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0003353 ! epithelium of hindgut +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000490 ! unilaminar epithelium +intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut +intersection_of: RO:0002202 UBERON:0000925 ! endoderm + [Term] id: UBERON:0003269 name: skeletal muscle tissue of eye +def: "A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000486 +xref: EHDAA:2923 +xref: EMAPA:17844 is_a: UBERON:0001134 ! skeletal muscle tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye +[Term] +id: UBERON:0003277 +name: skeleton of upper jaw +def: "A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000622 +xref: EHDAA2:0002128 +xref: EHDAA:8041 +xref: EMAPA:17927 +xref: FMA:54397 +xref: MA:0001908 +xref: VHOG:0000429 +xref: XAO:0003087 +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010912 ! subdivision of skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: RO:0002576 UBERON:0001709 ! upper jaw region +relationship: BFO:0000050 UBERON:0001708 ! part of jaw skeleton +relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: RO:0002576 UBERON:0001709 ! upper jaw region + [Term] id: UBERON:0003278 name: skeleton of lower jaw +def: "A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000274 +xref: EHDAA2:0004606 +xref: EHDAA:8005 +xref: EMAPA:17910 +xref: FMA:54398 +xref: MA:0001906 +xref: TAO:0001273 +xref: VHOG:0000428 +xref: XAO:0003084 +xref: ZFA:0001273 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton @@ -36410,15 +53725,81 @@ relationship: RO:0002576 UBERON:0001710 ! lower jaw region [Term] id: UBERON:0003279 name: endothelium of trachea +def: "An endothelium that is part of a trachea." [OBOL:automatic] +xref: EHDAA:3082 +xref: RETIRED_EHDAA2:0002068 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001901 ! epithelium of trachea is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea +[Term] +id: UBERON:0003281 +name: mesentery of stomach +def: "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum." [http://medical-dictionary.thefreedictionary.com/mesogastrium] +xref: EHDAA2:0001922 +xref: EHDAA:2999 +xref: EMAPA:17024 +xref: MA:0001617 +xref: SCTID:261623000 +xref: VHOG:0000358 +is_a: UBERON:0004854 ! gastrointestinal system mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach +relationship: BFO:0000050 UBERON:0000945 ! part of stomach +relationship: RO:0002433 UBERON:0000945 ! stomach + +[Term] +id: UBERON:0003282 +name: mesentery of heart +def: "A mesentery that surrounds the heart." [MA:th] +xref: EHDAA:432 +xref: EMAPA:16212 +xref: RETIRED_EHDAA2:0000739 +xref: VHOG:0000353 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0000948 ! part of heart +relationship: BFO:0000050 UBERON:0000948 ! part of heart + +[Term] +id: UBERON:0003283 +name: mesentery of oesophagus +def: "A mesentery that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001288 +xref: EHDAA:2943 +xref: EMAPA:16836 +xref: MA:0001569 +xref: VHOG:0000415 +is_a: UBERON:0001975 ! serosa of esophagus +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus + +[Term] +id: UBERON:0003284 +name: mesentery of midgut +def: "A mesentery that is part of a midgut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001202 +xref: EHDAA:3031 +xref: EMAPA:16721 +xref: EMAPA:17039 +xref: EMAPA:17197 +xref: VHOG:0000413 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut +relationship: BFO:0000050 UBERON:0001045 ! part of midgut + [Term] id: UBERON:0003294 name: gland of foregut +def: "A gland that is part of a foregut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000567 +xref: EHDAA:950 +xref: EMAPA:16557 +xref: VHOG:0000650 is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut @@ -36427,6 +53808,11 @@ relationship: BFO:0000050 UBERON:0001041 ! part of foregut [Term] id: UBERON:0003295 name: pharyngeal gland +def: "Racemose mucous glands beneath the mucous membrane of the pharynx." [http://www.biology-online.org/dictionary/] +xref: BTO:0004849 +xref: EHDAA2:0001461 +xref: EHDAA:2967 +xref: FMA:55075 is_a: UBERON:0003408 ! gland of digestive tract is_a: UBERON:0036225 ! respiratory system gland intersection_of: UBERON:0002530 ! gland @@ -36436,6 +53822,11 @@ relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx [Term] id: UBERON:0003297 name: gland of integumental system +def: "A gland that is part of a integumental system [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000837 +xref: EMAPA:17758 +xref: MA:0000144 +xref: VHOG:0000654 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system @@ -36444,6 +53835,9 @@ relationship: BFO:0000050 UBERON:0002416 ! part of integumental system [Term] id: UBERON:0003304 name: mesoderm blood island +def: "A blood island that is part of a mesoderm." [OBOL:automatic] +xref: EHDAA2:0003241 +xref: EHDAA:170 is_a: UBERON:0003061 ! blood island is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007503 ! epithelial vesicle @@ -36456,6 +53850,11 @@ relationship: BFO:0000050 UBERON:0007798 ! part of vascular system [Term] id: UBERON:0003314 name: eye mesenchyme +def: "Mesenchyme that is part of a developing camera-type eye." [OBOL:automatic] +xref: EHDAA2:0000485 +xref: EHDAA:2910 +xref: EMAPA:16673 +xref: VHOG:0001084 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0009891 ! facial mesenchyme intersection_of: UBERON:0003104 ! mesenchyme @@ -36466,32 +53865,161 @@ relationship: RO:0002202 UBERON:0009920 ! optic neural crest [Term] id: UBERON:0003315 name: mesenchyme of ovary +def: "Mesenchyme that is part of a developing ovary [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001362 +xref: EHDAA:8128 +xref: VHOG:0001441 is_a: UBERON:0003855 ! gonad mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003316 name: mesenchyme of yolk sac +def: "The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme." [UBERON:cjm] +xref: EHDAA2:0002216 +xref: EHDAA:168 +xref: EHDAA:205 +xref: EMAPA:16087 +xref: EMAPA:16267 +xref: VHOG:0000503 +xref: VHOG:0000617 is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001040 ! part of yolk sac relationship: BFO:0000050 UBERON:0001040 ! part of yolk sac +[Term] +id: UBERON:0003323 +name: mesenchyme of upper jaw +def: "Mesenchyme that is part of a developing upper jaw [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0002124 +xref: EHDAA:8031 +xref: EMAPA:17929 +xref: VHOG:0001099 +is_a: UBERON:0009891 ! facial mesenchyme +is_a: UBERON:0034995 ! jaw mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: RO:0002202 UBERON:0009526 ! maxillary process mesenchyme + [Term] id: UBERON:0003324 name: mesenchyme of lower jaw +def: "Mesenchyme that is part of a developing lower jaw [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001024 +xref: EHDAA:8003 +xref: EMAPA:17916 +xref: VHOG:0001069 is_a: UBERON:0034995 ! jaw mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: RO:0002202 UBERON:0006905 ! mandibular process mesenchyme +[Term] +id: UBERON:0003329 +name: submucosa of anal canal +def: "A submucosa that is part of an anal canal [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27217 +xref: EMAPA:27227 +xref: EMAPA:27535 +xref: FMA:85399 +xref: SCTID:7892006 +is_a: UBERON:0001208 ! submucosa of large intestine +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal + +[Term] +id: UBERON:0003330 +name: submucosa of rectum +def: "The submucous layer of the wall of the rectum." [BTO:0002114] +xref: BTO:0002114 +xref: EMAPA:27083 +xref: FMA:15034 +xref: SCTID:71683001 +is_a: UBERON:0001208 ! submucosa of large intestine +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + +[Term] +id: UBERON:0003331 +name: submucosa of colon +def: "A submucosa that is part of a colon [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27379 +xref: FMA:14985 +xref: MA:0003200 +xref: SCTID:61647009 +is_a: UBERON:0001208 ! submucosa of large intestine +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0003332 +name: submucosa of duodenum +def: "A submucosa that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27027 +xref: EMAPA:27097 +xref: EMAPA:27239 +xref: FMA:14943 +xref: MA:0003213 +xref: SCTID:76519004 +is_a: UBERON:0001205 ! submucosa of small intestine +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + +[Term] +id: UBERON:0003334 +name: serosa of rectum +def: "A serous membrane that is part of a rectum [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27087 +xref: FMA:15039 +is_a: UBERON:0001209 ! serosa of large intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + +[Term] +id: UBERON:0003335 +name: serosa of colon +def: "A serous membrane that is part of a colon [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27387 +xref: FMA:14990 +xref: MA:0003199 +xref: SCTID:90132000 +is_a: UBERON:0001209 ! serosa of large intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0003336 +name: serosa of duodenum +def: "A serous membrane that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27247 +xref: FMA:14948 +xref: MA:0003212 +xref: SCTID:1236009 +is_a: UBERON:0001206 ! serosa of small intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + [Term] id: UBERON:0003338 name: ganglion of peripheral nervous system +def: "A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO)." [BIRNLEX:2548] +xref: BIRNLEX:2548 +xref: BTO:0001123 +xref: EMAPA:32814 +xref: MA:0001161 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system @@ -36500,23 +54028,60 @@ relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system [Term] id: UBERON:0003339 name: ganglion of central nervous system +def: "A ganglion that is part of a central nervous system [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000227 +xref: EMAPA:16658 +xref: FMA:83843 is_a: UBERON:0000045 ! ganglion is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system +[Term] +id: UBERON:0003342 +name: mucosa of anal canal +def: "A mucosa that is part of an anal canal [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27531 +xref: FMA:74654 +xref: NCIT:C60784 +xref: SCTID:362170004 +is_a: UBERON:0001207 ! mucosa of large intestine +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal + [Term] id: UBERON:0003343 name: mucosa of oral region +def: "A mucosa that is part of a oral opening [Automatically generated definition]." [OBOL:automatic] +xref: SCTID:362083000 is_a: UBERON:0003729 ! mouth mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000166 ! part of oral opening relationship: BFO:0000050 UBERON:0000166 ! part of oral opening +[Term] +id: UBERON:0003346 +name: mucosa of rectum +def: "A mucosa that is part of a rectum [Automatically generated definition]." [OBOL:automatic] +xref: CALOHA:TS-2107 +xref: EMAPA:27081 +xref: FMA:15033 +xref: MA:0003218 +xref: SCTID:362167003 +is_a: UBERON:0001207 ! mucosa of large intestine +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + [Term] id: UBERON:0003350 name: epithelium of mucosa +def: "A layer of epithelial cells on the surface of the mucosa." [BTO:0003752] +comment: lies on top of lamina propria +xref: BTO:0003752 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000344 ! part of mucosa @@ -36525,6 +54090,15 @@ relationship: BFO:0000050 UBERON:0000344 ! part of mucosa [Term] id: UBERON:0003351 name: pharyngeal epithelium +def: "An epithelium that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] +xref: BSA:0000112 +xref: BTO:0005240 +xref: EMAPA:16708 +xref: MA:0002725 +xref: RETIRED_EHDAA2:0001460 +xref: TAO:0001174 +xref: XAO:0003202 +xref: ZFA:0001174 is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0005911 ! endo-epithelium @@ -36533,9 +54107,53 @@ intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: RO:0002202 UBERON:0007690 ! early pharyngeal endoderm +[Term] +id: UBERON:0003352 +name: epithelium of midgut +def: "An epithelium that is part of a midgut." [OBOL:automatic] +xref: BTO:0005053 +xref: EHDAA2:0001195 +xref: EMAPA:16569 +xref: MA:0003205 +is_a: UBERON:0003929 ! digestive tract epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut +relationship: BFO:0000050 UBERON:0001045 ! part of midgut + +[Term] +id: UBERON:0003353 +name: epithelium of hindgut +def: "An epithelium that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000782 +xref: EMAPA:16717 +xref: MA:0003206 +is_a: UBERON:0003929 ! digestive tract epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut +relationship: BFO:0000050 UBERON:0001046 ! part of hindgut + +[Term] +id: UBERON:0003354 +name: epithelium of rectum +def: "An epithelium that is part of a rectum [Automatically generated definition]." [OBOL:automatic] +xref: CALOHA:TS-2066 +xref: EHDAA2:0001594 +xref: EMAPA:17898 +xref: FMA:17510 +xref: MA:0003219 +xref: VHOG:0001037 +is_a: UBERON:0001278 ! epithelium of large intestine +is_a: UBERON:0016885 ! epithelium of terminal part of digestive tract +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + [Term] id: UBERON:0003364 name: epithelium of right lung +def: "An epithelium that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:17663 +xref: MA:0003132 is_a: UBERON:0000115 ! lung epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -36544,6 +54162,9 @@ relationship: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0003365 name: epithelium of left lung +def: "An epithelium that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:17655 +xref: MA:0003131 is_a: UBERON:0000115 ! lung epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung @@ -36552,6 +54173,10 @@ relationship: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0003372 name: pectoral appendage bud ectoderm +def: "An unilaminar epithelium that surrounds a pectoral appendage bud." [OBOL:automatic] +xref: EHDAA2:0002134 +xref: EMAPA:16407 +xref: VHOG:0001047 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium @@ -36565,15 +54190,26 @@ relationship: RO:0002202 UBERON:0000076 ! external ectoderm [Term] id: UBERON:0003379 name: cardiac muscle of right atrium +def: "A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0004155 +xref: EMAPA:17326 +xref: FMA:7282 +xref: SCTID:362018002 +xref: VHOG:0001227 is_a: UBERON:0004490 ! cardiac muscle tissue of atrium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium relationship: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003380 name: cardiac muscle of left atrium +def: "A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0004154 +xref: EMAPA:17320 +xref: FMA:7285 +xref: SCTID:189936008 +xref: VHOG:0001225 is_a: UBERON:0004490 ! cardiac muscle tissue of atrium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium @@ -36582,6 +54218,10 @@ relationship: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium [Term] id: UBERON:0003381 name: cardiac muscle of right ventricle +def: "A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:17342 +xref: FMA:83452 +xref: VHOG:0001236 is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle @@ -36590,6 +54230,10 @@ relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle [Term] id: UBERON:0003382 name: cardiac muscle of left ventricle +def: "A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:17339 +xref: FMA:83453 +xref: VHOG:0001234 is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle @@ -36598,15 +54242,21 @@ relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle [Term] id: UBERON:0003383 name: cardiac muscle tissue of interventricular septum +def: "A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0004158 +xref: EMAPA:17335 +xref: FMA:84084 +xref: VHOG:0000999 is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum is_a: UBERON:0004667 ! interventricular septum muscular part intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003384 name: skeletal muscle tissue of pharynx +def: "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18963 is_a: UBERON:0004830 ! respiratory system skeletal muscle intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx @@ -36615,6 +54265,9 @@ relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx [Term] id: UBERON:0003386 name: smooth muscle of eye +def: "Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi." [MGI:cwg, MP:0005247] +xref: EMAPA:18807 +xref: MA:0001268 is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -36625,16 +54278,23 @@ relationship: RO:0002433 UBERON:0001015 ! musculature [Term] id: UBERON:0003387 name: smooth muscle of trachea +def: "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001391 +xref: EMAPA:19192 +xref: FMA:262010 +xref: MA:0001863 +xref: NCIT:C49306 is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002433 UBERON:0003126 ! trachea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003388 name: mesothelium of pericardial cavity +def: "A mesothelium that is part of a pericardium [Automatically generated definition]." [OBOL:automatic] +xref: RETIRED_EHDAA2:0001436 is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: BFO:0000050 UBERON:0002407 ! part of pericardium @@ -36643,6 +54303,8 @@ relationship: BFO:0000050 UBERON:0002407 ! part of pericardium [Term] id: UBERON:0003389 name: mesothelium of diaphragm +def: "A mesothelium that is part of a diaphragm [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18429 is_a: UBERON:0001136 ! mesothelium is_a: UBERON:0004807 ! respiratory system epithelium intersection_of: UBERON:0001136 ! mesothelium @@ -36652,14 +54314,76 @@ relationship: BFO:0000050 UBERON:0001103 ! part of diaphragm [Term] id: UBERON:0003390 name: mesothelium of pleural cavity +def: "A mesothelium that is part of a pleural cavity [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0003155 +xref: EHDAA2:0001476 +xref: EMAPA:16775 +xref: FMA:18148 is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: RO:0001025 UBERON:0002402 ! pleural cavity relationship: RO:0001025 UBERON:0002402 ! pleural cavity +[Term] +id: UBERON:0003393 +name: mesentery of urinary system +def: "A mesentery that is part of a urinary system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:17367 +xref: MA:0003233 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001008 ! part of renal system +relationship: BFO:0000050 UBERON:0001008 ! part of renal system + +[Term] +id: UBERON:0003394 +name: mesentery of hindgut +def: "A mesentery that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:16718 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut +relationship: BFO:0000050 UBERON:0001046 ! part of hindgut + +[Term] +id: UBERON:0003395 +name: mesentery of rectum +def: "A mesentery that is part of a rectum [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18664 +is_a: UBERON:0003334 ! serosa of rectum +is_a: UBERON:0004854 ! gastrointestinal system mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum + +[Term] +id: UBERON:0003396 +name: mesentery of colon +def: "A mesentery that is part of a colon [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18942 +xref: FMA:14645 +xref: SCTID:245457004 +is_a: UBERON:0003335 ! serosa of colon +is_a: UBERON:0004854 ! gastrointestinal system mesentery +is_a: UBERON:0007826 ! peritoneal mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0003397 +name: mesentery of duodenum +def: "A mesentery that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:19081 +is_a: UBERON:0001170 ! mesentery of small intestine +is_a: UBERON:0003336 ! serosa of duodenum +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum + [Term] id: UBERON:0003406 name: cartilage of respiratory system +def: "A cartilage element that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18694 +xref: MA:0001818 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -36668,6 +54392,9 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003408 name: gland of digestive tract +def: "A gland that is part of a digestive tract [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18815 +xref: MA:0003202 is_a: UBERON:0002530 ! gland is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0002530 ! gland @@ -36677,6 +54404,12 @@ relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: UBERON:0003413 name: pectoral appendage bud mesenchyme +def: "Mesenchyme that is part of a pectoral appendage bud." [OBOL:automatic] +xref: EHDAA2:0002135 +xref: EHDAA:1703 +xref: EMAPA:16408 +xref: TAO:0000789 +xref: ZFA:0000789 is_a: UBERON:0010329 ! paired limb/fin bud mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005419 ! part of pectoral appendage bud @@ -36686,6 +54419,8 @@ relationship: RO:0002202 UBERON:0005729 ! pectoral appendage field [Term] id: UBERON:0003426 name: dermis adipose tissue +def: "An adipose tissue that is part of a dermis [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000798 is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003585 ! dermis connective tissue intersection_of: UBERON:0001013 ! adipose tissue @@ -36694,6 +54429,8 @@ intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis [Term] id: UBERON:0003429 name: abdomen nerve +def: "A nerve that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000521 is_a: UBERON:0003825 ! nerve of abdominal segment intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -36702,6 +54439,8 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0003430 name: neck nerve +def: "A nerve that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000588 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -36710,6 +54449,9 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0003438 name: iris nerve +def: "Any nerve that innervates the iris." [UBERON:cjm] +xref: EMAPA:35449 +xref: MA:0001291 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001769 ! iris @@ -36718,6 +54460,8 @@ relationship: RO:0002134 UBERON:0001769 ! iris [Term] id: UBERON:0003439 name: nerve of trunk region +def: "A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk)." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000515 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -36726,14 +54470,33 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0003443 name: thoracic cavity nerve +def: "A nerve that is located in a thoracic cavity [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000556 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0001025 UBERON:0002224 ! thoracic cavity relationship: RO:0001025 UBERON:0002224 ! thoracic cavity +[Term] +id: UBERON:0003452 +name: trabecula carnea cardiac muscle tissue +def: "A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36573 +xref: FMA:84428 +xref: MA:0002833 +is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle +intersection_of: UBERON:0001133 ! cardiac muscle tissue +intersection_of: BFO:0000050 UBERON:0002511 ! part of trabecula carnea +relationship: BFO:0000050 UBERON:0002511 ! part of trabecula carnea + [Term] id: UBERON:0003457 name: head bone +def: "A bone that is part of a head [Automatically generated definition]." [OBOL:automatic] +comment: Different sources vary regarding which bones are craniofacial; e.g. hyoid bone +xref: EMAPA:35996 +xref: MA:0000576 +xref: SCTID:118646007 is_a: UBERON:0007914 ! bone of craniocervical region intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -36742,6 +54505,8 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0003458 name: neck bone +def: "A bone that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000584 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -36750,6 +54515,13 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0003462 name: facial bone +def: "A bone that is part of a facial skeleton [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:19019 +xref: EMAPA:35924 +xref: MA:0001482 +xref: MA:0003159 +xref: NCIT:C63706 +xref: SCTID:181799005 is_a: UBERON:0003457 ! head bone is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001474 ! bone element @@ -36759,6 +54531,10 @@ relationship: BFO:0000050 UBERON:0011156 ! part of facial skeleton [Term] id: UBERON:0003463 name: trunk bone +def: "A bone that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36583 +xref: MA:0000512 +xref: SCTID:427358002 is_a: UBERON:0001474 ! bone element is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0001474 ! bone element @@ -36767,25 +54543,49 @@ intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0003469 name: respiratory system artery +def: "An artery that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001804 is_a: UBERON:0001637 ! artery is_a: UBERON:0003643 ! respiratory system arterial blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system +[Term] +id: UBERON:0003470 +name: artery of upper lip +def: "The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose." [Wikipedia:Superior_labial_artery] +xref: FMA:49570 +xref: MA:0001917 +xref: SCTID:145137009 +xref: Wikipedia:Superior_labial_artery +is_a: UBERON:0003496 ! head blood vessel +is_a: UBERON:0009657 ! artery of lip +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0001834 ! upper lip +relationship: RO:0002178 UBERON:0001834 ! upper lip +relationship: RO:0002252 UBERON:0001612 ! facial artery + [Term] id: UBERON:0003471 name: artery of lower lip +def: "The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery." [Wikipedia:Inferior_labial_artery] +xref: FMA:49567 +xref: MA:0001916 +xref: SCTID:145036002 +xref: Wikipedia:Inferior_labial_artery is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009657 ! artery of lip intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0001835 ! lower lip relationship: RO:0002178 UBERON:0001835 ! lower lip relationship: RO:0002252 UBERON:0001612 ! facial artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003473 name: thoracic cavity artery +def: "An artery that is part of a thoracic cavity[cjm]." [https://sourceforge.net/tracker/index.php?func=detail&aid=3317815&group_id=76834&atid=1205376] +xref: MA:0001902 +xref: MESH:D013895 is_a: UBERON:0001637 ! artery is_a: UBERON:0003519 ! thoracic cavity blood vessel intersection_of: UBERON:0001637 ! artery @@ -36794,31 +54594,68 @@ intersection_of: RO:0001025 UBERON:0002224 ! thoracic cavity [Term] id: UBERON:0003476 name: respiratory system venous blood vessel +def: "A vein that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001809 +xref: MA:0001810 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0001004 ! respiratory system relationship: RO:0002179 UBERON:0001004 ! respiratory system +[Term] +id: UBERON:0003477 +name: vein of upper lip +def: "The inferior labial vein is the vein receiving blood from the upper lip." [Wikipedia:Superior_labial_vein] +xref: FMA:52538 +xref: MA:0002255 +xref: SCTID:422755007 +xref: Wikipedia:Superior_labial_vein +is_a: UBERON:0013136 ! vein of lip +intersection_of: UBERON:0001638 ! vein +intersection_of: RO:0002179 UBERON:0001834 ! upper lip +relationship: RO:0002179 UBERON:0001834 ! upper lip + [Term] id: UBERON:0003478 name: vein of lower lip +def: "The inferior labial vein is the vein receiving blood from the lower lip." [Wikipedia:Inferior_labial_vein] +xref: FMA:52541 +xref: MA:0002253 +xref: SCTID:422955002 +xref: Wikipedia:Inferior_labial_vein is_a: UBERON:0013136 ! vein of lip intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0001835 ! lower lip relationship: RO:0002179 UBERON:0001835 ! lower lip -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003479 name: thoracic cavity vein +def: "A vein that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001903 is_a: UBERON:0001638 ! vein is_a: UBERON:0003519 ! thoracic cavity blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: RO:0001025 UBERON:0002224 ! thoracic cavity +[Term] +id: UBERON:0003481 +name: tail vein +def: "A vein that is part of a tail [Automatically generated definition]." [OBOL:automatic, Wikipedia:Tail_vein] +xref: AAO:0011105 +xref: MA:0002233 +xref: Wikipedia:Tail_vein +xref: XAO:0000393 +is_a: UBERON:0001638 ! vein +is_a: UBERON:0003524 ! tail blood vessel +intersection_of: UBERON:0001638 ! vein +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:0003489 name: respiratory system capillary endothelium +def: "An endothelium of capillary that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001808 is_a: UBERON:0001915 ! endothelium of capillary is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001915 ! endothelium of capillary @@ -36828,6 +54665,8 @@ relationship: BFO:0000050 UBERON:0003526 ! part of respiratory system capillary [Term] id: UBERON:0003494 name: respiratory system venule +def: "A venule that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001813 is_a: UBERON:0001979 ! venule is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001979 ! venule @@ -36836,6 +54675,8 @@ intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003495 name: respiratory system arteriole +def: "An arteriole that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001803 is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003643 ! respiratory system arterial blood vessel intersection_of: UBERON:0001980 ! arteriole @@ -36845,6 +54686,10 @@ relationship: BFO:0000050 UBERON:0003469 ! part of respiratory system artery [Term] id: UBERON:0003496 name: head blood vessel +def: "A blood vessel that is part of a head [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36610 +xref: MA:0000575 +xref: SCTID:127865000 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -36853,6 +54698,8 @@ relationship: BFO:0000050 UBERON:0011362 ! part of cranial blood vasculature [Term] id: UBERON:0003497 name: abdomen blood vessel +def: "A blood vessel that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000518 is_a: UBERON:0003835 ! abdominal segment blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -36861,6 +54708,9 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0003498 name: heart blood vessel +def: "A blood vessel that is part of a heart [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35397 +xref: MA:0002483 is_a: UBERON:0003834 ! thoracic segment blood vessel is_a: UBERON:0005985 ! coronary vessel intersection_of: UBERON:0001981 ! blood vessel @@ -36870,6 +54720,9 @@ relationship: BFO:0000050 UBERON:0018674 ! part of heart vasculature [Term] id: UBERON:0003499 name: brain blood vessel +def: "A blood vessel that is part of a brain [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35182 +xref: MA:0002769 is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001981 ! blood vessel @@ -36879,6 +54732,9 @@ relationship: BFO:0000050 UBERON:0008998 ! part of vasculature of brain [Term] id: UBERON:0003500 name: corneal blood vessel +def: "A blood vessel that is part of a cornea [Automatically generated definition]." [https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/tracker/index.php?func=detail&aid=3564332&group_id=36855&atid=440764] +xref: EMAPA:36611 +xref: MA:0001241 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001981 ! blood vessel @@ -36888,6 +54744,13 @@ relationship: BFO:0000050 UBERON:0000964 ! part of cornea [Term] id: UBERON:0003501 name: retina blood vessel +def: "A blood vessel that is part of a retina [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36520 +xref: GAID:509 +xref: MA:0001317 +xref: MESH:D012171 +xref: SCTID:280692003 +xref: XAO:0004153 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001981 ! blood vessel @@ -36898,6 +54761,8 @@ relationship: RO:0002433 UBERON:0000966 ! retina [Term] id: UBERON:0003502 name: neck blood vessel +def: "A blood vessel that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000583 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -36906,6 +54771,10 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0003504 name: respiratory system blood vessel +def: "A blood vessel that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35731 +xref: EMAPA:35995 +xref: MA:0001799 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -36914,6 +54783,9 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003505 name: trachea blood vessel +def: "A blood vessel that is part of a trachea." [OBOL:automatic] +xref: EMAPA:35874 +xref: MA:0001852 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001981 ! blood vessel @@ -36923,6 +54795,10 @@ relationship: BFO:0000050 UBERON:0003126 ! part of trachea [Term] id: UBERON:0003509 name: arterial blood vessel +def: "A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta." [https://orcid.org/0000-0002-6601-2165] +comment: only in MA - supertype of artery, arteriole, aorta. +xref: EMAPA:35144 +xref: MA:0000061 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0004572 ! part of arterial system @@ -36931,6 +54807,8 @@ relationship: BFO:0000050 UBERON:0004572 ! part of arterial system [Term] id: UBERON:0003511 name: iris blood vessel +def: "A blood vessel that is part of a iris [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001290 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001981 ! blood vessel @@ -36940,6 +54818,9 @@ relationship: BFO:0000050 UBERON:0004118 ! part of vasculature of iris [Term] id: UBERON:0003512 name: lung blood vessel +def: "A blood vessel that is part of a lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:32867 +xref: MA:0002457 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003504 ! respiratory system blood vessel is_a: UBERON:0003834 ! thoracic segment blood vessel @@ -36951,6 +54832,8 @@ relationship: RO:0002433 UBERON:0002048 ! lung [Term] id: UBERON:0003513 name: trunk blood vessel +def: "A blood vessel that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000511 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -36959,14 +54842,29 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0003519 name: thoracic cavity blood vessel +def: "A blood vessel that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000554 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: RO:0001025 UBERON:0002224 ! thoracic cavity relationship: RO:0001025 UBERON:0002224 ! thoracic cavity +[Term] +id: UBERON:0003524 +name: tail blood vessel +def: "A blood vessel that is part of a tail [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35848 +xref: MA:0000695 +is_a: UBERON:0001981 ! blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:0003526 name: respiratory system capillary +def: "A capillary that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001807 is_a: UBERON:0001982 ! capillary is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001982 ! capillary @@ -36975,14 +54873,34 @@ intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003528 name: brain gray matter +def: "A gray matter that is part of a brain [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35184 +xref: MA:0000810 +xref: NCIT:C49333 is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain +[Term] +id: UBERON:0003534 +name: tail skin +def: "A zone of skin that is part of a tail [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36502 +xref: MA:0000700 +xref: SCTID:67214004 +is_a: UBERON:0000014 ! zone of skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:0003536 name: right lung alveolar duct +def: "An alveolar duct that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35819 +xref: MA:0001785 +xref: NCIT:C49277 is_a: UBERON:0002173 ! pulmonary alveolar duct intersection_of: UBERON:0002173 ! pulmonary alveolar duct intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -36991,6 +54909,11 @@ relationship: BFO:0000050 UBERON:0006526 ! part of right lung alveolar system [Term] id: UBERON:0003537 name: left lung alveolar duct +def: "An alveolar duct that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +comment: Mice have 1 left lobe +xref: EMAPA:19183 +xref: MA:0001776 +xref: NCIT:C49250 is_a: UBERON:0002173 ! pulmonary alveolar duct intersection_of: UBERON:0002173 ! pulmonary alveolar duct intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung @@ -36999,6 +54922,11 @@ relationship: BFO:0000050 UBERON:0006525 ! part of left lung alveolar system [Term] id: UBERON:0003538 name: right lung bronchiole +def: "A bronchiole that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35425 +xref: MA:0001787 +xref: NCIT:C49279 +xref: SCTID:200089000 is_a: UBERON:0002186 ! bronchiole intersection_of: UBERON:0002186 ! bronchiole intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -37007,6 +54935,11 @@ relationship: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0003539 name: left lung bronchiole +def: "A bronchiole that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:19000 +xref: MA:0001778 +xref: NCIT:C49252 +xref: SCTID:200484003 is_a: UBERON:0002186 ! bronchiole intersection_of: UBERON:0002186 ! bronchiole intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung @@ -37015,6 +54948,10 @@ relationship: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0003540 name: right lung terminal bronchiole +def: "A terminal bronchiole that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36638 +xref: MA:0001789 +xref: NCIT:C49294 is_a: UBERON:0002187 ! terminal bronchiole is_a: UBERON:0003538 ! right lung bronchiole intersection_of: UBERON:0002187 ! terminal bronchiole @@ -37023,6 +54960,10 @@ intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0003541 name: left lung terminal bronchiole +def: "A terminal bronchiole that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36636 +xref: MA:0001780 +xref: NCIT:C49255 is_a: UBERON:0002187 ! terminal bronchiole is_a: UBERON:0003539 ! left lung bronchiole intersection_of: UBERON:0002187 ! terminal bronchiole @@ -37031,6 +54972,10 @@ intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0003542 name: right lung respiratory bronchiole +def: "A respiratory bronchiole that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36637 +xref: MA:0001788 +xref: NCIT:C49285 is_a: UBERON:0002188 ! respiratory bronchiole is_a: UBERON:0003538 ! right lung bronchiole intersection_of: UBERON:0002188 ! respiratory bronchiole @@ -37039,6 +54984,10 @@ intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0003543 name: left lung respiratory bronchiole +def: "A respiratory bronchiole that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36635 +xref: MA:0001779 +xref: NCIT:C49254 is_a: UBERON:0002188 ! respiratory bronchiole is_a: UBERON:0003539 ! left lung bronchiole intersection_of: UBERON:0002188 ! respiratory bronchiole @@ -37047,6 +54996,8 @@ intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0003566 name: head connective tissue +def: "A portion of connective tissue that is part of a head [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000577 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -37056,6 +55007,8 @@ relationship: RO:0002494 UBERON:0005253 ! head mesenchyme [Term] id: UBERON:0003567 name: abdomen connective tissue +def: "A portion of connective tissue that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000519 is_a: UBERON:0003838 ! abdominal segment connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -37064,6 +55017,8 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0003568 name: neck connective tissue +def: "A portion of connective tissue that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000585 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -37072,6 +55027,10 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0003570 name: respiratory system connective tissue +def: "A portion of connective tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35968 +xref: EMAPA:35977 +xref: MA:0001814 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -37080,16 +55039,20 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003571 name: trachea connective tissue +def: "A portion of connective tissue that is part of a trachea." [OBOL:automatic] +xref: EMAPA:35876 +xref: MA:0001853 is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002494 UBERON:0009505 ! mesenchyme of trachea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003580 name: lower respiratory tract connective tissue +def: "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002409 is_a: UBERON:0003570 ! respiratory system connective tissue is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0002384 ! connective tissue @@ -37099,6 +55062,9 @@ relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract [Term] id: UBERON:0003585 name: dermis connective tissue +def: "A portion of connective tissue that is part of a dermis [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36509 +xref: MA:0000799 is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002384 ! connective tissue @@ -37109,6 +55075,8 @@ relationship: RO:0002202 UBERON:0004016 ! dermatome [Term] id: UBERON:0003586 name: trunk connective tissue +def: "A portion of connective tissue that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000513 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -37117,6 +55085,11 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0003592 name: bronchus connective tissue +def: "A portion of connective tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:32690 +xref: EMAPA:35193 +xref: MA:0001831 +xref: NCIT:C49210 is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus @@ -37125,14 +55098,29 @@ relationship: BFO:0000050 UBERON:0002185 ! part of bronchus [Term] id: UBERON:0003593 name: thoracic cavity connective tissue +def: "A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000555 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0001025 UBERON:0002224 ! thoracic cavity relationship: RO:0001025 UBERON:0002224 ! thoracic cavity +[Term] +id: UBERON:0003599 +name: tail connective tissue +def: "A portion of connective tissue that is part of a tail [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:16749 +xref: MA:0000697 +is_a: UBERON:0002384 ! connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:0003601 name: neck cartilage +def: "A cartilage that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000586 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -37141,6 +55129,9 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0003603 name: lower respiratory tract cartilage +def: "A cartilage that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001819 +xref: NCIT:C49256 is_a: UBERON:0003406 ! cartilage of respiratory system is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0007844 ! cartilage element @@ -37150,16 +55141,25 @@ relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract [Term] id: UBERON:0003604 name: trachea cartilage +def: "The ring-shaped cartilaginous structures that support the trachea." [http://orcid.org/0000-0002-6601-2165, J:97123, MGI:smb, MP:0003120] +xref: EMAPA:18699 +xref: EMAPA:35875 +xref: FMA:7434 +xref: MA:0001857 +xref: NCIT:C49304 +xref: SCTID:278979006 +xref: Wikipedia:Tracheal_rings is_a: UBERON:0003603 ! lower respiratory tract cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 UBERON:0007267 ! trachea pre-cartilage rings -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003605 name: eye skin gland +def: "A skin gland that is part of a camera-type eye [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002451 is_a: UBERON:0002419 ! skin gland is_a: UBERON:0004859 ! eye gland is_a: UBERON:0015152 ! gland of ocular region @@ -37170,6 +55170,8 @@ relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye [Term] id: UBERON:0003609 name: aorta elastic tissue +def: "The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall." [MP:0009862] +xref: MA:0002859 is_a: UBERON:0003614 ! blood vessel elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta @@ -37178,6 +55180,8 @@ relationship: BFO:0000050 UBERON:0000947 ! part of aorta [Term] id: UBERON:0003610 name: heart elastic tissue +def: "The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers." [MP:0009863] +xref: MA:0002858 is_a: UBERON:0003613 ! cardiovascular system elastic tissue is_a: UBERON:0003837 ! thoracic segment connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure @@ -37188,6 +55192,8 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: UBERON:0003611 name: respiratory system elastic tissue +def: "An elastic tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001820 is_a: UBERON:0002521 ! elastic tissue is_a: UBERON:0003570 ! respiratory system connective tissue intersection_of: UBERON:0002521 ! elastic tissue @@ -37197,6 +55203,8 @@ relationship: BFO:0000050 UBERON:0004777 ! part of respiratory system submucosa [Term] id: UBERON:0003613 name: cardiovascular system elastic tissue +def: "An elastic tissue that is part of a circulatory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002857 is_a: UBERON:0002521 ! elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0001009 ! part of circulatory system @@ -37205,6 +55213,9 @@ relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system [Term] id: UBERON:0003614 name: blood vessel elastic tissue +def: "Elastic tissue layer that lines a blood vessel layer." [http://orcid.org/0000-0002-6601-2165, https://sourceforge.net/p/obo/mammalian-phenotype-requests/2026/] +xref: EMAPA:36300 +xref: MA:0002856 is_a: UBERON:0003613 ! cardiovascular system elastic tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002521 ! elastic tissue @@ -37214,6 +55225,8 @@ relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel [Term] id: UBERON:0003615 name: lung elastic tissue +def: "Elastic tissue that is part of a lung [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002860 is_a: UBERON:0000114 ! lung connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue @@ -37222,6 +55235,9 @@ intersection_of: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: UBERON:0003616 name: bronchus elastic tissue +def: "An elastic tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001838 +xref: NCIT:C49211 is_a: UBERON:0003592 ! bronchus connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue @@ -37231,16 +55247,22 @@ relationship: BFO:0000050 UBERON:0001957 ! part of submucosa of bronchus [Term] id: UBERON:0003617 name: trachea elastic tissue +def: "An elastic tissue that is part of a trachea [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001861 is_a: UBERON:0003571 ! trachea connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0002202 ! part of submucosa of trachea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003618 name: aorta tunica media +def: "The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers." [MP:0009873] +xref: EMAPA:35138 +xref: FMA:74433 +xref: MA:0002903 +xref: SCTID:48467007 is_a: UBERON:0002522 ! tunica media intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta @@ -37250,6 +55272,12 @@ relationship: RO:0002433 UBERON:0004663 ! aorta wall [Term] id: UBERON:0003619 name: aorta tunica intima +def: "The innermost layer of the aorta, containing the endothelium and an inner elastic membrane." [MP:0009872] +xref: BTO:0005553 +xref: EMAPA:35137 +xref: FMA:74419 +xref: MA:0002904 +xref: SCTID:362031007 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004797 ! blood vessel layer intersection_of: UBERON:0002523 ! tunica intima @@ -37260,14 +55288,41 @@ relationship: RO:0002433 UBERON:0004663 ! aorta wall [Term] id: UBERON:0003643 name: respiratory system arterial blood vessel +def: "An arterial blood vessel that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001800 is_a: UBERON:0003504 ! respiratory system blood vessel is_a: UBERON:0003509 ! arterial blood vessel intersection_of: UBERON:0003509 ! arterial blood vessel intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system +[Term] +id: UBERON:0003665 +name: post-anal tail muscle +def: "A muscle organ that attaches to a tail vertebra [Automatically generated definition]." [OBOL:automatic] +xref: AAO:0000081 +xref: BTO:0001905 +xref: MA:0000699 +xref: SCTID:113230005 +is_a: UBERON:0004518 ! muscle of vertebral column +intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate +intersection_of: RO:0002371 UBERON:0001095 ! caudal vertebra +relationship: RO:0002131 UBERON:0007812 ! overlaps post-anal tail +relationship: RO:0002371 UBERON:0001095 ! caudal vertebra + [Term] id: UBERON:0003684 name: abdominal cavity +def: "The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity)." [UBERON:cjm] +xref: EFO:0000213 +xref: EMAPA:36505 +xref: FMA:12266 +xref: GAID:17 +xref: galen:AbdominalCavity +xref: MA:0003057 +xref: MESH:D034841 +xref: NCIT:C12664 +xref: SCTID:361294009 +xref: Wikipedia:Abdominal_cavity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen @@ -37278,31 +55333,131 @@ relationship: RO:0002572 UBERON:0000916 ! abdomen [Term] id: UBERON:0003687 name: foramen magnum +def: "In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]." [Wikipedia:Foramen_magnum] +comment: Design pattern notes: check whether this fits the foramen design pattern +xref: AAO:0010826 +xref: FMA:75306 +xref: GAID:228 +xref: MESH:D005539 +xref: NCIT:C12495 +xref: SCTID:244679008 +xref: TAO:0002045 +xref: Wikipedia:Foramen_magnum +xref: ZFA:0005387 is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0013685 ! foramen of skull intersection_of: RO:0002570 UBERON:0001896 ! medulla oblongata relationship: RO:0001025 UBERON:0001676 ! occipital bone relationship: RO:0002570 UBERON:0001896 ! medulla oblongata +[Term] +id: UBERON:0003694 +name: atlanto-axial joint +def: "The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas." [Wikipedia:Atlanto-axial_joint] +xref: FMA:25524 +xref: GAID:250 +xref: MESH:D001268 +xref: NCIT:C32157 +xref: SCTID:361832004 +xref: Wikipedia:Atlanto-axial_joint +is_a: UBERON:0000982 ! skeletal joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: RO:0002176 UBERON:0001092 ! vertebral bone 1 +intersection_of: RO:0002176 UBERON:0001093 ! vertebral bone 2 +relationship: BFO:0000050 UBERON:0011138 ! part of postcranial axial skeletal system +relationship: RO:0002176 UBERON:0001092 ! vertebral bone 1 +relationship: RO:0002176 UBERON:0001093 ! vertebral bone 2 + [Term] id: UBERON:0003697 name: abdominal wall +def: "The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles." [ncithesaurus:Abdominal_Wall] +xref: FMA:10429 +xref: FMA:259054 +xref: GAID:26 +xref: MESH:D034861 +xref: NCIT:C77608 +xref: SCTID:181613000 +xref: Wikipedia:Abdominal_wall is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0000916 ! part of abdomen +[Term] +id: UBERON:0003703 +name: extrahepatic bile duct +def: "Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct." [MESH:A03.159.183.079] +xref: FMA:14678 +xref: GAID:281 +xref: MA:0002659 +xref: MESH:D017734 +xref: NCIT:C32573 +xref: SCTID:276158002 +is_a: UBERON:0002394 ! bile duct + +[Term] +id: UBERON:0003704 +name: intrahepatic bile duct +def: "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct." [MESH:A03.159.183.158] +xref: FMA:15766 +xref: GAID:287 +xref: MA:0001630 +xref: MESH:D001653 +xref: NCIT:C12677 +xref: SCTID:362193005 +xref: TAO:0005169 +xref: ZFA:0005169 +is_a: UBERON:0002394 ! bile duct +intersection_of: UBERON:0002394 ! bile duct +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver +relationship: RO:0002433 UBERON:0002107 ! liver + [Term] id: UBERON:0003711 name: brachiocephalic vein +def: "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava." [Wikipedia:Brachiocephalic_vein] +xref: EHDAA2:0000182 +xref: EHDAA:9868 +xref: FMA:4723 +xref: GAID:529 +xref: galen:BrachiocephalicVein +xref: MESH:D016121 +xref: NCIT:C32816 +xref: SCTID:181371003 +xref: Wikipedia:Brachiocephalic_vein is_a: UBERON:0001638 ! vein relationship: BFO:0000050 UBERON:0007204 ! part of brachiocephalic vasculature relationship: RO:0002170 UBERON:0001585 ! anterior vena cava -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0003713 +name: splenic vein +def: "A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein." [ncithesaurus:Splenic_Vein] +xref: FMA:14331 +xref: GAID:541 +xref: galen:SplenicVein +xref: MA:0002164 +xref: MESH:D013162 +xref: NCIT:C33608 +xref: SCTID:278029005 +xref: Wikipedia:Splenic_vein +is_a: UBERON:0001638 ! vein +relationship: RO:0002170 UBERON:0001639 ! hepatic portal vein [Term] id: UBERON:0003714 name: neural tissue +def: "Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature." [FMA:9642] +xref: AAO:0000325 +xref: AEO:0000123 +xref: EHDAA2:0003123 +xref: FMA:9642 +xref: GAID:609 +xref: MESH:D009417 +xref: NCIT:C13052 +xref: SCTID:91728009 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000051 CL:0000125 ! has part glial cell @@ -37315,30 +55470,60 @@ relationship: BFO:0000051 CL:0000540 ! has part neuron [Term] id: UBERON:0003715 name: splanchnic nerve +def: "The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia." [MP:0008318] +xref: BAMS:spn +xref: FMA:5883 +xref: GAID:800 +xref: MESH:D013153 +xref: SCTID:264198001 +xref: Wikipedia:Splanchnic_nerves is_a: UBERON:0034729 ! sympathetic nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0000916 ! abdomen relationship: RO:0002134 UBERON:0000916 ! abdomen relationship: RO:0002433 UBERON:0000013 ! sympathetic nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003726 name: thoracic nerve +def: "The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls." [MESH:A08.800.800.720.800] +xref: FMA:5860 +xref: GAID:857 +xref: MESH:D013900 +xref: neuronames:1725 +xref: SCTID:360498003 +xref: Wikipedia:Thoracic_nerves is_a: UBERON:0001780 ! spinal nerve intersection_of: UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0003038 ! thoracic spinal cord relationship: extends_fibers_into UBERON:0003038 ! thoracic spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003727 name: intercostal nerve +def: "The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]." [Wikipedia:Intercostal_nerves] +xref: EMAPA:18227 +xref: FMA:6028 +xref: GAID:858 +xref: MESH:D007367 +xref: NCIT:C32825 +xref: SCTID:279568001 +xref: Wikipedia:Intercostal_nerves is_a: UBERON:0001780 ! spinal nerve [Term] id: UBERON:0003729 name: mouth mucosa +def: "A mucous membrane that lines the mouth." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0002860 +xref: CALOHA:TS-0716 +xref: EMAPA:26937 +xref: FMA:59660 +xref: GAID:951 +xref: MA:0002794 +xref: MESH:D009061 +xref: NCIT:C77637 +xref: Wikipedia:Oral_mucosa is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000165 ! part of mouth @@ -37351,6 +55536,10 @@ relationship: RO:0002433 UBERON:0001007 ! digestive system [Term] id: UBERON:0003824 name: nerve of thoracic segment +def: "A nerve that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000562 +xref: MESH:D013900 +xref: SCTID:359876006 is_a: UBERON:0003439 ! nerve of trunk region intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -37359,6 +55548,8 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0003825 name: nerve of abdominal segment +def: "A nerve that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000528 is_a: UBERON:0003439 ! nerve of trunk region intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -37367,6 +55558,9 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003827 name: thoracic segment bone +def: "A bone that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000559 +xref: SCTID:426649006 is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0001474 ! bone element @@ -37375,6 +55569,8 @@ intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0003828 name: abdominal segment bone +def: "A bone that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000525 is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0001474 ! bone element @@ -37383,6 +55579,8 @@ intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003830 name: thoracic segment muscle +def: "Any muscle organ that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000561 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate @@ -37392,6 +55590,9 @@ relationship: BFO:0000050 UBERON:0004464 ! part of musculature of thorax [Term] id: UBERON:0003831 name: respiratory system muscle +def: "Any muscle organ that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35733 +xref: MA:0001828 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -37400,6 +55601,10 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003832 name: esophagus muscle +def: "Any muscle organ that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:26983 +xref: MA:0002682 +xref: SCTID:360961009 is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0013765 ! digestive system element @@ -37410,6 +55615,8 @@ relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus [Term] id: UBERON:0003833 name: abdominal segment muscle +def: "A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000527 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate @@ -37418,6 +55625,8 @@ intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003834 name: thoracic segment blood vessel +def: "A blood vessel that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000558 is_a: UBERON:0003513 ! trunk blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -37426,6 +55635,8 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0003835 name: abdominal segment blood vessel +def: "A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000524 is_a: UBERON:0003513 ! trunk blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -37434,6 +55645,9 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003836 name: abdominal segment skin +def: "A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: FMA:264898 +xref: MA:0000530 is_a: UBERON:0001085 ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -37442,6 +55656,8 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003837 name: thoracic segment connective tissue +def: "A portion of connective tissue that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000560 is_a: UBERON:0003586 ! trunk connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -37450,6 +55666,8 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0003838 name: abdominal segment connective tissue +def: "A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000526 is_a: UBERON:0003586 ! trunk connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -37458,6 +55676,14 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003842 name: neural tube lumen +def: "An anatomical space that surrounded_by a neural tube." [OBOL:automatic] +xref: AAO:0011073 +xref: EHDAA2:0001269 +xref: EHDAA:2889 +xref: EHDAA:914 +xref: EMAPA:16167 +xref: VHOG:0001119 +xref: XAO:0000252 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001049 ! neural tube @@ -37467,6 +55693,12 @@ relationship: RO:0002572 UBERON:0001049 ! neural tube [Term] id: UBERON:0003848 name: gonadal vein +def: "In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]." [Wikipedia:Gonadal_vein] +xref: EHDAA2:0000719 +xref: EHDAA:8703 +xref: SCTID:278192008 +xref: VHOG:0001340 +xref: Wikipedia:Gonadal_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002371 UBERON:0000991 ! gonad @@ -37475,6 +55707,13 @@ relationship: RO:0002371 UBERON:0000991 ! gonad [Term] id: UBERON:0003849 name: mesencephalic neural crest +def: "A neural crest that has_potential_to_developmentally_contribute_to a midbrain." [OBOL:automatic] +xref: EFO:0003591 +xref: EHDAA2:0001101 +xref: EHDAA:360 +xref: TAO:0000935 +xref: VHOG:0000796 +xref: ZFA:0000935 is_a: UBERON:0002342 ! neural crest is_a: UBERON:0003099 ! cranial neural crest intersection_of: UBERON:0002342 ! neural crest @@ -37484,6 +55723,13 @@ relationship: RO:0002385 UBERON:0001891 ! midbrain [Term] id: UBERON:0003852 name: rhombencephalon neural crest +def: "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain." [OBOL:automatic] +xref: EHDAA2:0001628 +xref: EHDAA:362 +xref: EMAPA:35747 +xref: TAO:0007063 +xref: VHOG:0001210 +xref: ZFA:0007063 is_a: UBERON:0002342 ! neural crest is_a: UBERON:0003099 ! cranial neural crest intersection_of: UBERON:0002342 ! neural crest @@ -37493,6 +55739,11 @@ relationship: RO:0002385 UBERON:0002028 ! hindbrain [Term] id: UBERON:0003853 name: spinal cord neural crest +def: "A neural crest that has_potential_to_developmentally_contribute_to a spinal cord." [OBOL:automatic] +xref: EHDAA:696 +xref: EMAPA:16163 +xref: EMAPA:16881 +xref: VHOG:0001006 is_a: UBERON:0002342 ! neural crest intersection_of: UBERON:0002342 ! neural crest intersection_of: RO:0002385 UBERON:0002240 ! spinal cord @@ -37501,6 +55752,11 @@ relationship: RO:0002385 UBERON:0002240 ! spinal cord [Term] id: UBERON:0003854 name: spinal cord neural plate +def: "A neural plate that develops_from a future spinal cord." [OBOL:automatic] +xref: FMA:312957 +xref: TAO:0007021 +xref: VHOG:0000439 +xref: ZFA:0007021 is_a: UBERON:0003075 ! neural plate intersection_of: UBERON:0003075 ! neural plate intersection_of: RO:0002202 UBERON:0006241 ! future spinal cord @@ -37509,6 +55765,11 @@ relationship: RO:0002202 UBERON:0006241 ! future spinal cord [Term] id: UBERON:0003855 name: gonad mesenchyme +def: "Mesenchyme that is part of a developing gonad [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA:5012 +xref: EMAPA:16858 +xref: EMAPA:17385 +xref: VHOG:0001090 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003104 ! mesenchyme @@ -37518,6 +55779,7 @@ relationship: BFO:0000050 UBERON:0000991 ! part of gonad [Term] id: UBERON:0003869 name: presumptive ganglion +def: "A presumptive structure that has the potential to develop into a ganglion." [OBOL:automatic] is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0000045 ! ganglion @@ -37526,6 +55788,7 @@ relationship: RO:0002387 UBERON:0000045 ! ganglion [Term] id: UBERON:0003886 name: future coelemic cavity lumen +def: "An anatomical cavity that has the potential to develop into a coelemic cavity lumen." [OBOL:automatic] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002387 UBERON:0002323 ! coelemic cavity lumen @@ -37537,6 +55800,12 @@ relationship: RO:0002492 UBERON:0000111 ! organogenesis stage [Term] id: UBERON:0003887 name: intraembryonic coelom +def: "The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom." [MGI:anna, MP:0012187] +xref: EHDAA:251 +xref: EMAPA:16088 +xref: NCIT:C34195 +xref: VHOG:0000316 +xref: Wikipedia:Intraembryonic_coelom is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0011997 ! part of coelom relationship: RO:0002202 UBERON:0003081 ! lateral plate mesoderm @@ -37544,13 +55813,44 @@ relationship: RO:0002202 UBERON:0003081 ! lateral plate mesoderm [Term] id: UBERON:0003891 name: stroma +def: "Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:81494 +xref: NCIT:C67387 is_a: UBERON:0000064 ! organ part relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa relationship: RO:0002473 UBERON:0002384 ! connective tissue +[Term] +id: UBERON:0003894 +name: liver primordium +def: "A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum." [ISBN:3211492755] +xref: AAO:0011058 +xref: BTO:0003391 +xref: EFO:0002577 +xref: EFO:0003428 +xref: EHDAA2:0000744 +xref: EHDAA:973 +xref: EMAPA:16847 +xref: NCIT:C34277 +xref: TAO:0000124 +xref: XAO:0003266 +xref: ZFA:0000124 +is_a: UBERON:0000485 ! simple columnar epithelium +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0006598 ! presumptive structure +is_a: UBERON:0009497 ! epithelium of foregut-midgut junction +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0002107 ! liver +relationship: BFO:0000050 UBERON:0009550 ! part of endoderm of foregut-midgut junction +relationship: RO:0002202 UBERON:0001041 ! foregut +relationship: RO:0002387 UBERON:0002107 ! liver + [Term] id: UBERON:0003898 name: skeletal muscle tissue of trunk +def: "A portion of skeletal muscle tissue in the trunk." [http://orcid.org/0000-0002-6601-2165] +xref: SCTID:244848007 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -37560,22 +55860,45 @@ relationship: BFO:0000050 UBERON:0013700 ! part of axial musculature [Term] id: UBERON:0003902 name: retinal neural layer +def: "The part of the retina that contains neurons and photoreceptor cells[GO]." [GO:0003407] +xref: AAO:0011095 +xref: BTO:0000929 +xref: CALOHA:TS-0685 +xref: EHDAA2:0001253 +xref: EHDAA:4763 +xref: EMAPA:17171 +xref: EMAPA:18590 +xref: FMA:58628 +xref: MA:0000277 +xref: NCIT:C33166 +xref: TAO:0000046 +xref: VHOG:0000535 +xref: XAO:0003216 +xref: ZFA:0000046 is_a: UBERON:0001781 ! layer of retina intersection_of: UBERON:0001781 ! layer of retina intersection_of: RO:0002495 UBERON:0005425 ! presumptive neural retina relationship: BFO:0000051 CL:0000210 ! has part photoreceptor cell relationship: RO:0002256 UBERON:0005426 ! lens vesicle relationship: RO:0002495 UBERON:0005425 ! presumptive neural retina -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003909 name: sinusoid +def: "Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]." [Wikipedia:Sinusoid_(blood_vessel)] +xref: FMA:63131 +xref: SCTID:340163004 +xref: TAO:0005261 +xref: Wikipedia:Sinusoid_(blood_vessel) +xref: ZFA:0005261 is_a: UBERON:2005260 ! fenestrated capillary [Term] id: UBERON:0003914 name: epithelial tube +def: "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GO:0060562, PMID:12526790] +xref: AEO:0000114 +xref: EHDAA2:0003114 is_a: UBERON:0000025 ! tube is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium @@ -37584,6 +55907,7 @@ intersection_of: RO:0000086 PATO:0002299 [Term] id: UBERON:0003915 name: endothelial tube +def: "Any endothelium that has the quality of being cylindrical [Automatically generated definition]." [OBOL:automatic] is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003914 ! epithelial tube intersection_of: UBERON:0001986 ! endothelium @@ -37592,15 +55916,99 @@ intersection_of: RO:0000086 PATO:0002299 [Term] id: UBERON:0003920 name: venous blood vessel +def: "A blood vessel that carries blood from the capillaries toward the heart." [http://www.thefreedictionary.com/venous+blood+vessel] +comment: Compare to: vein +xref: EMAPA:35932 +xref: FMA:86188 +xref: MA:0000066 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0004582 ! part of venous system relationship: BFO:0000050 UBERON:0004582 ! part of venous system -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0003921 +name: pancreas primordium +def: "Embryonic structure that develops into pancreatic bud." [Wikipedia:Pancreas#Embryological_development] +xref: EFO:0002579 +xref: EFO:0003434 +xref: EHDAA2:0001382 +xref: EHDAA:2163 +xref: EMAPA:17066 +xref: FMA:79792 +xref: TAO:0000254 +xref: XAO:0001101 +xref: ZFA:0000254 +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0001264 ! pancreas +relationship: BFO:0000050 UBERON:0007026 ! part of presumptive gut +relationship: RO:0002202 UBERON:0000925 ! endoderm +relationship: RO:0002387 UBERON:0001264 ! pancreas + +[Term] +id: UBERON:0003922 +name: pancreatic epithelial bud +def: "The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]." [PMID:16417468, Wikipedia:Pancreatic_bud] +xref: EFO:0003470 +xref: EMAPA:35645 +xref: NCIT:C34242 +xref: SCTID:360398004 +xref: TAO:0001390 +xref: Wikipedia:Pancreatic_bud +xref: ZFA:0001390 +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0007499 ! epithelial sac +relationship: BFO:0000050 UBERON:0003921 ! part of pancreas primordium +relationship: RO:0002202 UBERON:0001041 ! foregut +relationship: RO:0002202 UBERON:0001555 ! digestive tract +relationship: RO:0002202 UBERON:0002114 ! duodenum +relationship: RO:0002202 UBERON:0009497 ! epithelium of foregut-midgut junction + +[Term] +id: UBERON:0003923 +name: dorsal pancreatic bud +def: "Pancreatic bud that gives rise to the accessory pancreatic duct." [Wikipedia:Pancreatic_bud] +xref: AAO:0011031 +xref: EFO:0003465 +xref: EHDAA2:0001385 +xref: EMAPA:17067 +xref: SCTID:361435005 +xref: TAO:0001370 +xref: VHOG:0001428 +xref: Wikipedia:Pancreatic_bud +xref: XAO:0000467 +xref: ZFA:0001370 +is_a: UBERON:0003922 ! pancreatic epithelial bud +relationship: BFO:0000050 UBERON:0010375 ! part of pancreas dorsal primordium +relationship: RO:0002202 UBERON:0001045 ! midgut + +[Term] +id: UBERON:0003924 +name: ventral pancreatic bud +def: "Pancreatic bud that gives rise to the major pancreatic duct." [Wikipedia:Pancreatic_bud] +xref: AAO:0011111 +xref: EFO:0003464 +xref: EHDAA2:0001389 +xref: EMAPA:17256 +xref: SCTID:361437002 +xref: TAO:0001369 +xref: VHOG:0001429 +xref: Wikipedia:Pancreatic_bud +xref: XAO:0001103 +xref: ZFA:0001369 +is_a: UBERON:0003922 ! pancreatic epithelial bud +relationship: BFO:0000050 UBERON:0010376 ! part of pancreas ventral primordium +relationship: RO:0002202 UBERON:0008835 ! hepatic diverticulum [Term] id: UBERON:0003928 name: digestive system duct +def: "A duct that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] +xref: TAO:0005162 +xref: ZFA:0005162 is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system @@ -37609,6 +56017,15 @@ relationship: BFO:0000050 UBERON:0001007 ! part of digestive system [Term] id: UBERON:0003929 name: digestive tract epithelium +def: "An epithelium that lines the lumen of the digestive tract." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000956 +xref: EHDAA2:0004567 +xref: EMAPA:32928 +xref: MA:0003201 +xref: NCIT:C12963 +xref: TAO:0005123 +xref: XAO:0003200 +xref: ZFA:0005123 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract @@ -37617,6 +56034,10 @@ relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: UBERON:0003932 name: cartilage element of chondrocranium +def: "A cartilage element of chondrocranium. Example: neurocranial trabecula." [https://orcid.org/0000-0002-6601-2165] +xref: EFO:0003690 +xref: TAO:0001461 +xref: ZFA:0001461 is_a: UBERON:0003933 ! cranial cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0002241 ! part of chondrocranium @@ -37625,6 +56046,9 @@ relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium [Term] id: UBERON:0003933 name: cranial cartilage +def: "A cartilage element that is part of the cranial skeleton." [https://orcid.org/0000-0002-6601-2165, ZFA:0001458] +xref: TAO:0001458 +xref: ZFA:0001458 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system @@ -37633,6 +56057,8 @@ relationship: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system [Term] id: UBERON:0003937 name: reproductive gland +def: "Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction." [MP:0000653] +xref: MA:0001751 is_a: UBERON:0002530 ! gland is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0002530 ! gland @@ -37641,6 +56067,10 @@ intersection_of: BFO:0000050 UBERON:0000990 ! part of reproductive system [Term] id: UBERON:0003942 name: somatosensory system +def: "The sensory system for the sense of touch and pain." [NLXANAT:090818] +xref: neuronames:2887 +xref: NLXANAT:090818 +xref: Wikipedia:Somatosensory_system is_a: UBERON:0001032 ! sensory system relationship: RO:0002216 GO:0019233 ! capable of part of sensory perception of pain relationship: RO:0002216 GO:0050975 ! capable of part of sensory perception of touch @@ -37648,6 +56078,7 @@ relationship: RO:0002216 GO:0050975 ! capable of part of sensory perception of t [Term] id: UBERON:0003952 name: anterior stroma of cornea +def: "The anterior segment of the lamellated connective tissue layer of the cornea." [MP:0003093] is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002384 ! connective tissue @@ -37655,11 +56086,11 @@ intersection_of: BSPO:0000123 UBERON:0001777 ! substantia propria of cornea relationship: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea relationship: BSPO:0000123 UBERON:0001777 ! substantia propria of cornea relationship: RO:0002433 UBERON:0001777 ! substantia propria of cornea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003953 name: posterior stroma of cornea +def: "The posterior segment of the lamellated connective tissue layer of the cornea." [MP:0003094] is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002384 ! connective tissue @@ -37671,6 +56102,7 @@ relationship: RO:0002433 UBERON:0001777 ! substantia propria of cornea [Term] id: UBERON:0003967 name: cutaneous elastic tissue +def: "The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity." [MP:0008418] is_a: UBERON:0002521 ! elastic tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0002521 ! elastic tissue @@ -37681,15 +56113,20 @@ relationship: RO:0002433 UBERON:0000014 ! zone of skin [Term] id: UBERON:0003975 name: internal female genitalia +def: "The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina." [MP:0009209] +comment: TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 +xref: BTO:0003099 +xref: FMA:45654 +xref: SCTID:303518005 is_a: UBERON:0003134 ! female reproductive organ is_a: UBERON:0004175 ! internal genitalia intersection_of: UBERON:0004175 ! internal genitalia intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004015 name: embryonic-extraembryonic boundary +def: "The connection between the embryo proper and extraembryonic tissues." [MP:0003890] is_a: UBERON:0000015 ! non-material anatomical boundary intersection_of: UBERON:0000015 ! non-material anatomical boundary intersection_of: RO:0002220 UBERON:0000478 ! adjacent to extraembryonic structure @@ -37700,12 +56137,26 @@ relationship: RO:0002220 UBERON:0002050 ! adjacent to embryonic structure [Term] id: UBERON:0004016 name: dermatome +def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells." [AEO:0001017, AEO:JB] +xref: AAO:0011028 +xref: AEO:0001017 +xref: EHDAA2_RETIRED:0003428 +xref: EHDAA:1719 +xref: EHDAA:1725 +xref: EHDAA:1731 +xref: EHDAA:1737 +xref: EMAPA:32838 +xref: FMA:295656 +xref: NCIT:C61572 +xref: Wikipedia:Dermatome_(embryology) +xref: XAO:0000220 is_a: UBERON:0017650 ! developing mesenchymal structure relationship: RO:0002202 UBERON:0004290 ! dermomyotome [Term] id: UBERON:0004022 name: germinal neuroepithelium +def: "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0004261] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0034706 ! proliferating neuroepithelium @@ -37714,9 +56165,27 @@ relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: RO:0002007 UBERON:0001049 ! bounding layer of neural tube relationship: RO:0002220 UBERON:0003842 ! adjacent to neural tube lumen +[Term] +id: UBERON:0004058 +name: biliary ductule +def: "One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]." [BTO:0002840, MP:0009494] +xref: BTO:0002840 +xref: TAO:0005164 +xref: ZFA:0005164 +is_a: UBERON:0000025 ! tube +is_a: UBERON:0004119 ! endoderm-derived structure +relationship: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002394 ! part of bile duct +relationship: RO:0002220 UBERON:0001175 ! adjacent to common hepatic duct + [Term] id: UBERON:0004060 name: neural tube ventricular layer +def: "The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009689] +xref: EMAPA:17152 +xref: EMAPA:35362 +xref: EMAPA_RETIRED:16783 +xref: MA:0003193 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0034706 ! proliferating neuroepithelium @@ -37727,6 +56196,10 @@ relationship: RO:0002495 UBERON:0004022 ! germinal neuroepithelium [Term] id: UBERON:0004061 name: neural tube mantle layer +def: "The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009690] +xref: EMAPA:17148 +xref: EMAPA:35360 +xref: neuronames:1367 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0034707 ! differentiating neuroepithelium @@ -37738,6 +56211,9 @@ relationship: RO:0002220 UBERON:0004062 ! adjacent to neural tube marginal layer [Term] id: UBERON:0004062 name: neural tube marginal layer +def: "The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009691] +xref: EMAPA:17151 +xref: neuronames:1368 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005162 ! multi cell part structure relationship: BFO:0000050 UBERON:0001049 ! part of neural tube @@ -37747,6 +56223,12 @@ relationship: RO:0002220 UBERON:0004061 ! adjacent to neural tube mantle layer [Term] id: UBERON:0004064 name: neural tube basal plate +def: "The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009693, Wikipedia:Basal_plate_(neural_tube)] +xref: AAO:0010561 +xref: EFO:0001904 +xref: NCIT:C34111 +xref: neuronames:1372 +xref: Wikipedia:Basal_plate_(neural_tube) is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0004061 ! part of neural tube mantle layer @@ -37755,21 +56237,82 @@ relationship: BSPO:0000102 UBERON:0005478 ! sulcus limitans of neural tube relationship: RO:0002256 UBERON:0002328 ! notochord relationship: RO:0002433 UBERON:0004061 ! neural tube mantle layer +[Term] +id: UBERON:0004066 +name: frontonasal prominence +def: "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout." [MP:0009901] +xref: EHDAA2:0000578 +xref: EHDAA:4778 +xref: EMAPA:16681 +xref: FMA:293101 +xref: NCIT:C34182 +xref: SCTID:361486000 +xref: VHOG:0001319 +xref: Wikipedia:Frontonasal_prominence +is_a: UBERON:0009292 ! embryonic nasal process +relationship: BSPO:0005001 UBERON:0000033 ! head + +[Term] +id: UBERON:0004068 +name: medial nasal prominence +def: "The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it." [MP:0009903, Wikipedia:Medial_nasal_prominence] +xref: EHDAA2:0001076 +xref: EHDAA:4792 +xref: EMAPA:16808 +xref: FMA:295858 +xref: SCTID:308877001 +xref: VHOG:0000804 +xref: Wikipedia:Medial_nasal_prominence +is_a: UBERON:0009292 ! embryonic nasal process +relationship: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence +relationship: BSPO:0000126 UBERON:0008816 ! embryonic head +relationship: RO:0002202 UBERON:0004066 ! frontonasal prominence + [Term] id: UBERON:0004087 name: vena cava +def: "Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Venae_cavae] +xref: AAO:0010215 +xref: BTO:0001438 +xref: EMAPA:18415 +xref: FMA:321896 +xref: GAID:547 +xref: MA:0000068 +xref: MESH:D014684 +xref: NCIT:C12817 +xref: SCTID:244405007 +xref: Wikipedia:Venae_cavae is_a: UBERON:0003479 ! thoracic cavity vein is_a: UBERON:0013768 ! great vessel of heart [Term] id: UBERON:0004088 name: orbital region +def: "The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:260119 +is_a: UBERON:0001444 ! subdivision of head +relationship: BFO:0000050 UBERON:0001456 ! part of face + +[Term] +id: UBERON:0004089 +name: midface +def: "The middle of the face including the nose and its associated bony structures[MW]." [HP:0000309, http://www.merriam-webster.com/medical/midface] +xref: FMA:285406 +xref: MA:0001910 is_a: UBERON:0001444 ! subdivision of head relationship: BFO:0000050 UBERON:0001456 ! part of face +relationship: RO:0002160 NCBITaxon:89593 ! Craniata +relationship: RO:0002433 UBERON:0001456 ! face [Term] id: UBERON:0004111 name: anatomical conduit +def: "Any tube, opening or passage that connects two distinct anatomical spaces." [http://orcid.org/0000-0002-6601-2165] +xref: AEO:0000080 +xref: EHDAA2:0003080 +xref: FMA:242873 +xref: SCTID:346902003 +xref: Wikipedia:Foramen is_a: UBERON:0010000 ! multicellular anatomical structure intersection_of: UBERON:0010000 ! multicellular anatomical structure intersection_of: BFO:0000051 UBERON:0013686 ! has part anatomical conduit space @@ -37777,13 +56320,12 @@ intersection_of: RO:0002570 UBERON:0000061 ! anatomical structure relationship: BFO:0000051 UBERON:0013686 ! has part anatomical conduit space relationship: RO:0002176 UBERON:0000464 {cardinality="2"} ! anatomical space relationship: RO:0002570 UBERON:0000061 ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0004118 name: vasculature of iris +def: "A vasculature that is part of a iris [Automatically generated definition]." [OBOL:automatic] +xref: ZFA:0005568 is_a: UBERON:0002203 ! vasculature of eye intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001769 ! part of iris @@ -37792,6 +56334,7 @@ relationship: BFO:0000050 UBERON:0001769 ! part of iris [Term] id: UBERON:0004119 name: endoderm-derived structure +def: "An anatomical structure that develops (entirely or partially) from the endoderm." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0000925 ! endoderm @@ -37800,6 +56343,7 @@ relationship: RO:0002202 UBERON:0000925 ! endoderm [Term] id: UBERON:0004120 name: mesoderm-derived structure +def: "An anatomical structure that develops (entirely or partially) from the mesoderm." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0000926 ! mesoderm @@ -37808,14 +56352,93 @@ relationship: RO:0002202 UBERON:0000926 ! mesoderm [Term] id: UBERON:0004121 name: ectoderm-derived structure +def: "An anatomical structure that develops (entirely or partially) from the ectoderm." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0000924 ! ectoderm relationship: RO:0002202 UBERON:0000924 ! ectoderm +[Term] +id: UBERON:0004122 +name: genitourinary system +def: "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction." [VHOG:0000286] +xref: AAO:0000624 +xref: BILA:0000122 +xref: BTO:0003091 +xref: EFO:0003864 +xref: EHDAA:1013 +xref: EMAPA:16367 +xref: EV:0100094 +xref: FMA:280610 +xref: GAID:362 +xref: galen:GenitoUrinarySystem +xref: MESH:D014566 +xref: NCIT:C12810 +xref: SCTID:278861008 +xref: VHOG:0000286 +xref: XAO:0000140 +is_a: UBERON:0000467 ! anatomical system +intersection_of: UBERON:0000467 ! anatomical system +intersection_of: BFO:0000051 UBERON:0000990 ! has part reproductive system +intersection_of: BFO:0000051 UBERON:0001008 ! has part renal system +relationship: BFO:0000051 UBERON:0000990 ! has part reproductive system +relationship: BFO:0000051 UBERON:0001008 ! has part renal system +relationship: RO:0002492 UBERON:0000066 ! fully formed stage + +[Term] +id: UBERON:0004123 +name: myocardial layer +def: "Any of the layers of the myocardium. Example: compact layer, trabecular layer." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000080 +is_a: UBERON:0005983 ! heart layer +intersection_of: UBERON:0004923 ! organ component layer +intersection_of: layer_part_of UBERON:0002349 ! myocardium +relationship: BFO:0000050 UBERON:0002349 ! part of myocardium +relationship: layer_part_of UBERON:0002349 ! myocardium + +[Term] +id: UBERON:0004124 +name: myocardium trabecular layer +def: "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA]." [ZFA:0005059] +xref: EFO:0003706 +xref: MA:0002866 +xref: TAO:0005059 +xref: ZFA:0005059 +is_a: UBERON:0004123 ! myocardial layer +intersection_of: UBERON:0004123 ! myocardial layer +intersection_of: RO:0002220 UBERON:0002165 ! adjacent to endocardium +intersection_of: RO:0002473 GO:0036194 ! muscle cell projection +relationship: RO:0002220 UBERON:0002165 ! adjacent to endocardium +relationship: RO:0002473 GO:0036194 ! muscle cell projection + +[Term] +id: UBERON:0004126 +name: trabecular layer of ventricle +def: "A myocardium trabecular layer that is part of a cardiac ventricle." [OBOL:automatic] +xref: FMA:83511 +xref: TAO:0005060 +xref: ZFA:0005060 +is_a: UBERON:0004124 ! myocardium trabecular layer +intersection_of: UBERON:0004124 ! myocardium trabecular layer +intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle +relationship: BFO:0000050 UBERON:0001083 ! part of myocardium of ventricle + [Term] id: UBERON:0004128 name: optic vesicle +def: "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]." [GO:0003404, Wikipedia:Optic_vesicles] +comment: Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 "Developmental Biology"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288] +xref: AAO:0011039 +xref: EHDAA2:0001320 +xref: EMAPA:16540 +xref: FMA:293357 +xref: NCIT:C34236 +xref: SCTID:362864008 +xref: TAO:0000050 +xref: VHOG:0000165 +xref: Wikipedia:Optic_vesicles +xref: XAO:0000228 +xref: ZFA:0000050 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0010312 ! part of immature eye @@ -37826,6 +56449,7 @@ relationship: RO:0002256 UBERON:0004880 ! chordamesoderm [Term] id: UBERON:0004133 name: salivatory nucleus +def: "Missing definition for term UBERON:0004133. Please replace it using linked reference." [GO:0021751] is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus relationship: BFO:0000050 UBERON:0000988 ! part of pons @@ -37833,12 +56457,18 @@ relationship: BFO:0000050 UBERON:0000988 ! part of pons [Term] id: UBERON:0004139 name: cardiogenic plate +def: "The first recognizable structure derived from the heart field." [GO:0003142] +xref: EHDAA2:0000215 +xref: EMAPA:16106 +xref: VHOG:0000975 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0003084 ! heart primordium [Term] id: UBERON:0004140 name: primary heart field +def: "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [GO:0003138, GOC:mtg_heart, GOC:rl] +xref: XAO:0004185 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -37849,6 +56479,14 @@ relationship: BFO:0000050 UBERON:0036146 ! part of cardiopharyngeal field [Term] id: UBERON:0004141 name: heart tube +def: "An epithelial tube that will give rise to the mature heart." [GO:0003143, GOC:mtg_heart] +xref: AAO:0010411 +xref: EFO:0003526 +xref: EMAPA:32685 +xref: NCIT:C34161 +xref: TAO:0000360 +xref: XAO:0000337 +xref: ZFA:0000360 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0012275 ! meso-epithelium @@ -37857,6 +56495,8 @@ relationship: RO:0002495 UBERON:0005498 ! primitive heart tube [Term] id: UBERON:0004142 name: outflow tract septum +def: "The outflow tract septum is a partition in the outflow tract." [GO:0003148] +xref: XAO:0004141 is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract @@ -37865,6 +56505,14 @@ relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract [Term] id: UBERON:0004145 name: outflow tract +def: "The outflow tract is the portion of the heart through which blood flows into the arteries." [GO:0003151] +xref: EHDAA2:0001351 +xref: EHDAA:464 +xref: EHDAA:798 +xref: EMAPA:16346 +xref: MA:0000100 +xref: VHOG:0000670 +xref: XAO:0004139 is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000948 ! part of heart @@ -37875,6 +56523,7 @@ relationship: channels_into UBERON:0001637 ! artery [Term] id: UBERON:0004146 name: His-Purkinje system +def: "The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GO:0003164, https://github.com/geneontology/go-ontology/issues/12451] is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BFO:0000050 UBERON:0002350 ! part of conducting system of heart @@ -37883,6 +56532,15 @@ relationship: RO:0002160 NCBITaxon:32523 ! Tetrapoda [Term] id: UBERON:0004148 name: cardiac vein +def: "Vein of heart that drains the myocardium." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0004507 +xref: FMA:12846 +xref: galen:CoronaryVein +xref: NCIT:C12878 +xref: NCIT:C12882 +xref: SCTID:277726009 +xref: Wikipedia:Coronary_circulation +xref: ZFA:0005814 is_a: UBERON:0003498 ! heart blood vessel is_a: UBERON:0005194 ! thoracic vein is_a: UBERON:0013140 ! systemic vein @@ -37894,6 +56552,10 @@ relationship: RO:0002179 UBERON:0002349 ! myocardium [Term] id: UBERON:0004151 name: cardiac chamber +def: "A cardiac chamber surrounds an enclosed cavity within the heart." [GO:0003205] +comment: generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus +xref: FMA:7095 +xref: SCTID:276456008 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000948 ! part of heart @@ -37901,6 +56563,9 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: UBERON:0004160 name: proepicardium +def: "An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium." [GO:0003342, http://en.wiktionary.org/wiki/proepicardium] +xref: EMAPA:36025 +xref: ZFA:0005808 is_a: UBERON:0003104 ! mesenchyme relationship: BFO:0000050 UBERON:0004161 ! part of septum transversum relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system @@ -37908,6 +56573,15 @@ relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system [Term] id: UBERON:0004161 name: septum transversum +def: "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]." [VHOG:0000019, Wikipedia:Septum_transversum] +xref: EHDAA2:0001829 +xref: EHDAA:736 +xref: EMAPA:16318 +xref: FMA:295593 +xref: NCIT:C34296 +xref: SCTID:308819008 +xref: VHOG:0000019 +xref: Wikipedia:Septum_transversum is_a: UBERON:0003104 ! mesenchyme relationship: BFO:0000050 UBERON:0002100 ! part of trunk relationship: RO:0001025 UBERON:0002323 ! coelemic cavity lumen @@ -37915,17 +56589,28 @@ relationship: RO:0001025 UBERON:0002323 ! coelemic cavity lumen [Term] id: UBERON:0004175 name: internal genitalia +def: "The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [GO:0035260] +comment: TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 +xref: FMA:45652 is_a: UBERON:0003133 ! reproductive organ -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004176 name: external genitalia +def: "The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [GO:0035261] +comment: TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 +xref: FMA:45643 +xref: SCTID:362207005 is_a: UBERON:0003133 ! reproductive organ [Term] id: UBERON:0004177 name: hemopoietic organ +def: "Organ that is part of the hematopoietic system." [GOC:Obol] +xref: BTO:0004605 +xref: FMA:7143 +xref: MA:0000747 +xref: SCTID:361338006 is_a: UBERON:0000062 ! organ is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000062 ! organ @@ -37935,6 +56620,13 @@ relationship: BFO:0000050 UBERON:0002390 ! part of hematopoietic system [Term] id: UBERON:0004178 name: aorta smooth muscle tissue +def: "The nonstriated, involuntary muscle tissue located in the wall of the aorta." [MGI:csmith, MP:0009865] +xref: BTO:0001685 +xref: CALOHA:TS-0048 +xref: EFO:0002775 +xref: EMAPA:35135 +xref: MA:0000702 +xref: NCIT:C49191 is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -37944,6 +56636,8 @@ relationship: BFO:0000050 UBERON:0000947 ! part of aorta [Term] id: UBERON:0004185 name: endodermal part of digestive tract +def: "A portions of the gut that is derived from endoderm." [GO:0061031] +xref: EMAPA:32930 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract @@ -37953,14 +56647,48 @@ intersection_of: RO:0002202 UBERON:0000925 ! endoderm [Term] id: UBERON:0004215 name: back nerve +def: "A nerve that is part of a back [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000497 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0001137 ! part of dorsum +[Term] +id: UBERON:0004220 +name: large intestine smooth muscle +def: "A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35469 +xref: MA:0001547 +is_a: UBERON:0004221 ! intestine smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine +relationship: RO:0002131 UBERON:0011198 ! overlaps muscle layer of large intestine + +[Term] +id: UBERON:0004221 +name: intestine smooth muscle +def: "A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000643 +xref: EMAPA:35441 +xref: EMAPA:35443 +xref: MA:0001539 +xref: NCIT:C49243 +is_a: UBERON:0004226 ! gastrointestinal system smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine +relationship: RO:0002131 UBERON:0012367 ! overlaps muscle layer of intestine +relationship: RO:0002433 UBERON:0000160 ! intestine + [Term] id: UBERON:0004222 name: stomach smooth muscle +def: "A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001818 +xref: EMAPA:35823 +xref: MA:0001627 is_a: UBERON:0004226 ! gastrointestinal system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach @@ -37969,6 +56697,10 @@ relationship: BFO:0000050 UBERON:0001167 ! part of wall of stomach [Term] id: UBERON:0004225 name: respiratory system smooth muscle +def: "A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001660 +xref: EMAPA:35734 +xref: MA:0001830 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -37977,14 +56709,30 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0004226 name: gastrointestinal system smooth muscle +def: "A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35117 +xref: MA:0001523 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system +[Term] +id: UBERON:0004231 +name: anal region smooth muscle +def: "A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001532 +is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region +relationship: BFO:0000050 UBERON:0001353 ! part of anal region + [Term] id: UBERON:0004233 name: lower respiratory tract smooth muscle +def: "A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35520 +xref: MA:0002410 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004225 ! respiratory system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -37994,6 +56742,11 @@ relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract [Term] id: UBERON:0004234 name: iris smooth muscle +def: "A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000655 +xref: EMAPA:35448 +xref: FMA:312338 +xref: MA:0001270 is_a: UBERON:0003386 ! smooth muscle of eye intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001769 ! part of iris @@ -38002,6 +56755,10 @@ relationship: BFO:0000050 UBERON:0001606 ! part of muscle of iris [Term] id: UBERON:0004236 name: arteriole smooth muscle +def: "A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36287 +xref: FMA:312251 +xref: MA:0000706 is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -38011,25 +56768,76 @@ relationship: BFO:0000050 UBERON:0001980 ! part of arteriole [Term] id: UBERON:0004237 name: blood vessel smooth muscle +def: "Smooth muscle found within, and composing the majority of the wall of blood vessels." [Wikipedia:Vascular_smooth_muscle] +xref: BTO:0001431 +xref: CALOHA:TS-1107 +xref: EMAPA:35177 +xref: MA:0000710 +xref: MESH:D009131 +xref: NCIT:C33853 +xref: TAO:0005321 +xref: Wikipedia:Vascular_smooth_muscle +xref: ZFA:0005321 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004238 +name: spleen smooth muscle +def: "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35807 +xref: MA:0000757 +is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + +[Term] +id: UBERON:0004239 +name: small intestine smooth muscle +def: "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35783 +xref: MA:0001559 +is_a: UBERON:0004221 ! intestine smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine +relationship: RO:0002131 UBERON:0011201 ! overlaps muscle layer of small intestine + +[Term] +id: UBERON:0004240 +name: gallbladder smooth muscle +def: "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35373 +xref: MA:0001635 +xref: NCIT:C49483 +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder [Term] id: UBERON:0004242 name: bronchus smooth muscle +def: "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004401 +xref: EMAPA:35195 +xref: MA:0001840 +xref: NCIT:C49213 is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000051 CL:0002598 ! has part bronchial smooth muscle cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004246 name: outflow tract smooth muscle +def: "A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000492 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract @@ -38038,6 +56846,8 @@ relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract [Term] id: UBERON:0004247 name: bone of dorsum +def: "A bone that is part of the dorsal region of an animal." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000494 is_a: UBERON:0001474 ! bone element is_a: UBERON:0005174 ! dorsal region element intersection_of: UBERON:0001474 ! bone element @@ -38046,6 +56856,11 @@ intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0004253 name: skin muscle +def: "Any muscle organ that is part of a skin of body [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18187 +xref: EMAPA:35776 +xref: MA:0002710 +xref: MA:0003139 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system @@ -38055,6 +56870,8 @@ relationship: RO:0001025 UBERON:0002097 ! skin of body [Term] id: UBERON:0004258 name: back blood vessel +def: "A blood vessel that is part of a back [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000493 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum @@ -38063,6 +56880,11 @@ relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0004265 name: outflow tract myocardium +def: "A myocardium that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001358 +xref: EMAPA:35623 +xref: MA:0000489 +xref: VHOG:0000603 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract @@ -38071,6 +56893,8 @@ relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract [Term] id: UBERON:0004267 name: back connective tissue +def: "A portion of connective tissue that is part of a back [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000495 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum @@ -38079,6 +56903,8 @@ relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0004271 name: outflow tract pericardium +def: "A pericardium that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000491 is_a: UBERON:0002407 ! pericardium is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002407 ! pericardium @@ -38088,6 +56914,10 @@ relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract [Term] id: UBERON:0004277 name: eye muscle +def: "A muscle that is part of the eye region." [OBOL:automatic] +xref: AAO:0000156 +xref: EMAPA:35335 +xref: MA:0000271 is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001630 ! muscle organ @@ -38098,15 +56928,40 @@ relationship: RO:0002433 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0004288 name: skeleton +def: "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body." [VSAO:0000026] +xref: AEO:0000168 +xref: EHDAA2:0001843 +xref: EHDAA:5047 +xref: EMAPA:17213 +xref: FMA:23875 +xref: GAID:177 +xref: galen:Skeleton +xref: MA:0003006 +xref: MAT:0000032 +xref: MESH:D012863 +xref: MIAA:0000032 +xref: SCTID:361378004 +xref: VSAO:0000026 +xref: Wikipedia:Skeleton +xref: XAO:0004053 is_a: UBERON:0034925 ! anatomical collection disjoint_from: UBERON:0004770 ! articular system relationship: BFO:0000050 UBERON:0001434 ! part of skeletal system relationship: RO:0002351 UBERON:0004765 ! skeletal element -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004290 name: dermomyotome +def: "The bilaminar epithelium formed from the myotome and dermatome." [AEO:0000214] +xref: AAO:0010572 +xref: AEO:0000214 +xref: EHDAA2:0003259 +xref: EMAPA:31109 +xref: FMA:295654 +xref: NCIT:C34140 +xref: TAO:0001513 +xref: VHOG:0000676 +xref: ZFA:0001513 is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0016888 ! transitional anatomical structure relationship: BFO:0000051 CL:0000075 ! has part columnar/cuboidal epithelial cell @@ -38115,12 +56970,19 @@ relationship: RO:0002202 UBERON:0002329 ! somite [Term] id: UBERON:0004291 name: heart rudiment +def: "A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GO:0003313] +xref: TAO:0000115 +xref: ZFA:0000115 is_a: UBERON:0012275 ! meso-epithelium relationship: RO:0002202 UBERON:0004139 ! cardiogenic plate [Term] id: UBERON:0004292 name: cardiac skeleton +def: "Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart." [GO:0003204, Wikipedia:Cardiac_skeleton] +xref: EMAPA:36645 +xref: FMA:9496 +xref: Wikipedia:Cardiac_skeleton is_a: UBERON:0003837 ! thoracic segment connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000948 ! part of heart @@ -38130,6 +56992,8 @@ relationship: RO:0002220 UBERON:0002082 ! adjacent to cardiac ventricle [Term] id: UBERON:0004297 name: respiratory system blood vessel smooth muscle +def: "A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001806 is_a: UBERON:0004225 ! respiratory system smooth muscle is_a: UBERON:0004237 ! blood vessel smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -38139,6 +57003,12 @@ relationship: BFO:0000050 UBERON:0003504 ! part of respiratory system blood vess [Term] id: UBERON:0004345 name: trophectoderm +def: "Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition." [MP:0005028] +xref: BTO:0001840 +xref: EHDAA2:0002091 +xref: EHDAA:56 +xref: EMAPA:16046 +xref: VHOG:0000979 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005292 ! extraembryonic tissue relationship: BFO:0000050 UBERON:0005631 ! part of extraembryonic membrane @@ -38148,12 +57018,25 @@ relationship: RO:0002202 UBERON:0000085 ! morula [Term] id: UBERON:0004348 name: optic eminence +def: "The embryonic structure that gives rise to the corneal ectoderm." [MP:0006305] +xref: EHDAA:938 +xref: EMAPA:16322 +xref: RETIRED_EHDAA2:0001308 +xref: VHOG:0001296 is_a: UBERON:0006598 ! presumptive structure relationship: RO:0002387 UBERON:0000964 ! cornea [Term] id: UBERON:0004356 name: apical ectodermal ridge +def: "Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]." [MP:0001676, Wikipedia:Apical_ectodermal_ridge] +xref: AAO:0010760 +xref: EMAPA:32744 +xref: NCIT:C34109 +xref: TAO:0002146 +xref: Wikipedia:Apical_ectodermal_ridge +xref: XAO:0004121 +xref: ZFA:0001702 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm relationship: BFO:0000050 UBERON:0004357 ! part of paired limb/fin bud @@ -38165,6 +57048,9 @@ relationship: RO:0003000 PR:000007499 ! produces [Term] id: UBERON:0004357 name: paired limb/fin bud +def: "An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." [https://orcid.org/0000-0002-6601-2165, ISBN:9780878932504, MP:0005650] +comment: Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056] +xref: VHOG:0001258 is_a: UBERON:0003102 ! surface structure is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000051 UBERON:0004356 ! has part apical ectodermal ridge @@ -38174,11 +57060,39 @@ relationship: RO:0002387 UBERON:0004708 ! paired limb/fin [Term] id: UBERON:0004362 name: pharyngeal arch 1 +def: "The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0010364 +xref: CALOHA:TS-2089 +xref: EHDAA2:0000006 +xref: EHDAA:573 +xref: EMAPA:16118 +xref: FMA:293019 +xref: MFMO:0000095 +xref: NCIT:C34175 +xref: SCTID:308767008 +xref: TAO:0001595 +xref: VHOG:0000296 +xref: Wikipedia:First_pharyngeal_arch +xref: XAO:0000097 +xref: ZFA:0001612 is_a: UBERON:0002539 ! pharyngeal arch [Term] id: UBERON:0004363 name: pharyngeal arch artery +def: "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]." [MP:0002672] +xref: AAO:0010414 +xref: EFO:0003695 +xref: EHDAA2:0000186 +xref: EHDAA:398 +xref: EHDAA:7327 +xref: EMAPA:16684 +xref: NCIT:C32123 +xref: TAO:0005004 +xref: VHOG:0000122 +xref: Wikipedia:Aortic_arches +xref: XAO:0000341 +xref: ZFA:0005004 is_a: UBERON:0003469 ! respiratory system artery is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0006598 ! presumptive structure @@ -38191,12 +57105,17 @@ relationship: RO:0002433 UBERON:0002539 ! pharyngeal arch [Term] id: UBERON:0004364 name: ectoplacental cone +def: "Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta." [MP:0001717, PMID:19829370] +xref: BTO:0001715 +xref: EMAPA:16059 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000088 ! part of trophoblast [Term] id: UBERON:0004365 name: vitelline blood vessel +def: "Blood vessel that is connected to the yolk sac." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:36494 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: RO:0002170 UBERON:0001040 ! yolk sac @@ -38206,6 +57125,18 @@ relationship: RO:0002170 UBERON:0001040 ! yolk sac [Term] id: UBERON:0004367 name: Descemet's membrane +def: "A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]." [https://github.com/obophenotype/uberon/issues/15, MP:0004285] +comment: The strong, resistant, thin, noncellular fourth layer of the cornea, located between the endothelium (from which it is secreted) and the stroma. (Cline et al., Dictionary of Visual Science, 4th ed) +xref: EMAPA:18804 +xref: FMA:58309 +xref: GAID:894 +xref: MA:0001246 +xref: MESH:D003886 +xref: NCIT:C32454 +xref: SCTID:281076002 +xref: TAO:0002157 +xref: Wikipedia:Descemet%27s_membrane +xref: ZFA:0001686 is_a: UBERON:0005769 ! basement membrane of epithelium is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0005769 ! basement membrane of epithelium @@ -38221,6 +57152,14 @@ relationship: RO:0003001 UBERON:0001985 ! produced by corneal endothelium [Term] id: UBERON:0004370 name: anterior limiting lamina of cornea +def: "A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane." [ncithesaurus:Bowman_s_Membrane] +xref: FMA:58273 +xref: MA:0001240 +xref: NCIT:C32226 +xref: SCTID:281075003 +xref: TAO:0002155 +xref: Wikipedia:Bowman%27s_membrane +xref: ZFA:0001684 is_a: UBERON:0005769 ! basement membrane of epithelium is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0005769 ! basement membrane of epithelium @@ -38232,6 +57171,8 @@ relationship: RO:0002371 UBERON:0001772 ! corneal epithelium [Term] id: UBERON:0004374 name: vitelline vasculature +def: "Vascular network that is connected to the yolk sac." [http://orcid.org/0000-0002-6601-2165] +xref: Wikipedia:Vitelline_circulation is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: RO:0002170 UBERON:0001040 ! yolk sac @@ -38240,15 +57181,33 @@ relationship: RO:0002170 UBERON:0001040 ! yolk sac [Term] id: UBERON:0004375 name: bone of free limb or fin +def: "A bone that is part of an appendage [Automatically generated definition]." [OBOL:automatic] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010740 ! bone of appendage girdle complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0004708 ! part of paired limb/fin relationship: BFO:0000050 UBERON:0011582 ! part of paired limb/fin skeleton +[Term] +id: UBERON:0004451 +name: trunk or cervical vertebra +def: "A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra." [UBERONREF:0000006] +xref: MA:0002869 +xref: XAO:0003077 +is_a: UBERON:0002412 ! vertebra +intersection_of: UBERON:0002412 ! vertebra +intersection_of: BSPO:0000096 UBERON:0001095 ! caudal vertebra +union_of: UBERON:0002413 ! cervical vertebra +union_of: UBERON:0011677 ! trunk vertebra +relationship: BSPO:0000096 UBERON:0001095 ! caudal vertebra + [Term] id: UBERON:0004455 name: neurula embryo +def: "An embryo at the neurula stage." [http://orcid.org/0000-0002-6601-2165] +xref: BILA:0000061 +xref: BTO:0001766 +xref: NCIT:C34229 is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002491 UBERON:0000110 ! neurula stage @@ -38258,6 +57217,8 @@ relationship: RO:0002491 UBERON:0000110 ! neurula stage [Term] id: UBERON:0004456 name: entire sense organ system +def: "Sum of all sensory systems in an organism." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:78499 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002131 UBERON:0001016 ! overlaps nervous system @@ -38266,6 +57227,10 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0004461 name: skeletal musculature of head +def: "Any collection of skeletal muscles that is part of a head [Automatically generated definition]." [OBOL:automatic] +comment: This class is restricted to skeletal muscles that attach to the cranial skeleton. This seems to be consistent with FMA and EMAPA usage. Note that by definition this excludes invertebrate head musculature. It corresponds to the individual muscle organ term UBERON:0002376 +xref: EMAPA:18171 +xref: FMA:71287 is_a: UBERON:0008229 ! craniocervical region musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -38278,6 +57243,9 @@ relationship: RO:0002371 UBERON:0003129 ! skull [Term] id: UBERON:0004464 name: musculature of thorax +def: "Any collection of muscles that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000508 +xref: FMA:71293 is_a: UBERON:0004479 ! musculature of trunk intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -38286,14 +57254,30 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0004465 name: musculature of neck +def: "Any collection of muscles that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: AAO:0000091 +xref: EMAPA:36050 +xref: FMA:71290 +xref: MESH:D009334 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck +[Term] +id: UBERON:0004468 +name: set of muscles of vertebral column +xref: FMA:33061 +is_a: UBERON:0001015 ! musculature +intersection_of: UBERON:0001015 ! musculature +intersection_of: RO:0002371 UBERON:0001130 ! vertebral column +relationship: RO:0002371 UBERON:0001130 ! vertebral column + [Term] id: UBERON:0004469 name: musculature of back +def: "Any collection of muscles that is part of a back [Automatically generated definition]." [OBOL:automatic] +xref: FMA:71291 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum @@ -38302,6 +57286,9 @@ relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0004471 name: musculature of pectoral girdle +def: "A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0000423 +xref: FMA:33519 is_a: UBERON:0014793 ! musculature of pectoral complex intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region @@ -38310,6 +57297,8 @@ relationship: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region [Term] id: UBERON:0004473 name: musculature of face +def: "Any collection of muscles that is part of a face." [OBOL:automatic] +xref: FMA:71288 is_a: UBERON:0008229 ! craniocervical region musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001456 ! part of face @@ -38318,6 +57307,10 @@ relationship: BFO:0000050 UBERON:0001456 ! part of face [Term] id: UBERON:0004479 name: musculature of trunk +def: "Any collection of muscles that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +xref: AAO:0011572 +xref: EFO:0003531 +xref: FMA:50187 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -38326,6 +57319,8 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0004490 name: cardiac muscle tissue of atrium +def: "A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]." [OBOL:automatic] +xref: FMA:7283 is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium @@ -38334,6 +57329,8 @@ relationship: BFO:0000050 UBERON:0002302 ! part of myocardium of atrium [Term] id: UBERON:0004491 name: cardiac muscle tissue of interatrial septum +def: "A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]." [OBOL:automatic] +xref: FMA:84083 is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002085 ! part of interatrial septum @@ -38342,6 +57339,8 @@ relationship: BFO:0000050 UBERON:0002085 ! part of interatrial septum [Term] id: UBERON:0004492 name: cardiac muscle tissue of cardiac septum +def: "A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]." [OBOL:automatic] +xref: FMA:226279 is_a: UBERON:0001133 ! cardiac muscle tissue intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002099 ! part of cardiac septum @@ -38350,6 +57349,9 @@ relationship: BFO:0000050 UBERON:0002099 ! part of cardiac septum [Term] id: UBERON:0004493 name: cardiac muscle tissue of myocardium +def: "A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]." [OBOL:automatic] +xref: FMA:261726 +xref: MA:0002441 is_a: UBERON:0001133 ! cardiac muscle tissue intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002349 ! part of myocardium @@ -38358,6 +57360,8 @@ relationship: BFO:0000050 UBERON:0002349 ! part of myocardium [Term] id: UBERON:0004495 name: skeletal muscle tissue of diaphragm +def: "A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition]." [OBOL:automatic] +xref: FMA:261898 is_a: UBERON:0003898 ! skeletal muscle tissue of trunk is_a: UBERON:0004830 ! respiratory system skeletal muscle intersection_of: UBERON:0001134 ! skeletal muscle tissue @@ -38367,35 +57371,50 @@ relationship: BFO:0000050 UBERON:0001103 ! part of diaphragm [Term] id: UBERON:0004515 name: smooth muscle tissue of bronchiole +def: "A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:261045 is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002186 ! part of bronchiole relationship: BFO:0000050 UBERON:0002186 ! part of bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004516 name: smooth muscle tissue of terminal bronchiole +def: "A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:261051 is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole relationship: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole relationship: BFO:0000051 CL:4033017 ! has part bronchiolar smooth muscle cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004517 name: smooth muscle tissue of respiratory bronchiole +def: "A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:261055 is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole relationship: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole relationship: BFO:0000051 CL:4033017 ! has part bronchiolar smooth muscle cell -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004518 +name: muscle of vertebral column +def: "A muscle that is attached to a vertebra of the vertebral column." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:22594 +is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate +intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate +intersection_of: RO:0002371 UBERON:0002412 ! vertebra +relationship: RO:0002371 UBERON:0002412 ! vertebra [Term] id: UBERON:0004521 name: vasculature of muscle organ +def: "A vasculature that is part of a muscle organ [Automatically generated definition]." [OBOL:automatic] +xref: FMA:87123 is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001630 ! part of muscle organ @@ -38404,14 +57423,61 @@ relationship: BFO:0000050 UBERON:0001630 ! part of muscle organ [Term] id: UBERON:0004522 name: vasculature of musculoskeletal system +def: "A vasculature that is part of a musculoskeletal system [Automatically generated definition]." [OBOL:automatic] +xref: FMA:239607 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002204 ! part of musculoskeletal system relationship: BFO:0000050 UBERON:0002204 ! part of musculoskeletal system +[Term] +id: UBERON:0004525 +name: cardiac muscle tissue of trabecula carnea of right ventricle +def: "A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]." [OBOL:automatic] +xref: FMA:84429 +is_a: UBERON:0003381 ! cardiac muscle of right ventricle +is_a: UBERON:0003452 ! trabecula carnea cardiac muscle tissue +intersection_of: UBERON:0003452 ! trabecula carnea cardiac muscle tissue +intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle +relationship: BFO:0000050 UBERON:0006570 ! part of trabecula carnea of right ventricle + +[Term] +id: UBERON:0004526 +name: cardiac muscle tissue of trabecula carnea of left ventricle +def: "A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]." [OBOL:automatic] +xref: FMA:84430 +is_a: UBERON:0003382 ! cardiac muscle of left ventricle +is_a: UBERON:0003452 ! trabecula carnea cardiac muscle tissue +intersection_of: UBERON:0003452 ! trabecula carnea cardiac muscle tissue +intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle +relationship: BFO:0000050 UBERON:0006571 ! part of trabecula carnea of left ventricle + [Term] id: UBERON:0004535 name: cardiovascular system +def: "Anatomical system that has as its parts the heart and blood vessels." [BTO:0000088] +xref: AAO:0011001 +xref: BILA:0000016 +xref: BTO:0000088 +xref: CALOHA:TS-1297 +xref: EFO:0000791 +xref: EHDAA:394 +xref: EMAPA:16104 +xref: EV:0100017 +xref: FMA:7161 +xref: GAID:467 +xref: MA:0000010 +xref: MAT:0000016 +xref: MESH:D002319 +xref: MIAA:0000016 +xref: NCIT:C12686 +xref: SCTID:278198007 +xref: TAO:0000010 +xref: VHOG:0000302 +xref: WikipediaCategory:Cardiovascular_system +xref: XAO:0000100 +xref: XAO:0001010 +xref: ZFA:0000010 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: BFO:0000050 UBERON:0001009 ! part of circulatory system @@ -38420,20 +57486,26 @@ intersection_of: BFO:0000051 UBERON:0001981 ! has part blood vessel relationship: BFO:0000050 UBERON:0001009 ! part of circulatory system relationship: BFO:0000051 UBERON:0000948 ! has part heart relationship: BFO:0000051 UBERON:0001981 ! has part blood vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004537 name: blood vasculature +def: "A vascular network consisting of blood vessels." [https://orcid.org/0000-0002-6601-2165] +xref: TAO:0001079 +xref: ZFA:0001079 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: RO:0002473 UBERON:0001981 ! blood vessel relationship: RO:0002473 UBERON:0001981 ! blood vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004548 name: left eye +def: "An eye that is part of a left side of organism [Automatically generated definition]." [OBOL:automatic] +xref: FMA:12515 +xref: MA:0002949 +xref: NCIT:C119334 +xref: SCTID:362503005 is_a: UBERON:0000970 ! eye is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000970 ! eye @@ -38443,6 +57515,11 @@ relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0004549 name: right eye +def: "An eye that is part of a right side of organism [Automatically generated definition]." [OBOL:automatic] +xref: FMA:12514 +xref: MA:0002950 +xref: NCIT:C119333 +xref: SCTID:362502000 is_a: UBERON:0000970 ! eye is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000970 ! eye @@ -38452,50 +57529,110 @@ relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0004571 name: systemic arterial system +def: "The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Systemic_circulation#Arteries] +xref: FMA:45623 +xref: Wikipedia:Systemic_circulation#Arteries is_a: UBERON:0007798 ! vascular system relationship: BFO:0000050 UBERON:0004572 ! part of arterial system [Term] id: UBERON:0004572 name: arterial system +def: "The part of the cardiovascular system consisting of all arteries." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0004690 +xref: EHDAA2:0000143 +xref: EHDAA:396 +xref: EMAPA:16201 +xref: EMAPA:16371 +xref: MA:0002719 +xref: SCTID:362030008 +xref: VHOG:0000273 is_a: UBERON:0007798 ! vascular system relationship: RO:0002351 UBERON:0001637 ! artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004573 name: systemic artery +def: "An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Artery#Systemic_arteries] +xref: FMA:66464 +xref: Wikipedia:Artery#Systemic_arteries is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0004571 ! part of systemic arterial system relationship: BFO:0000050 UBERON:0004571 ! part of systemic arterial system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004581 name: systemic venous system +def: "The part of the venous system that drains the general body tissues[Kardong]." [ISBN:0073040584, Wikipedia:Systemic_venous_system] +xref: FMA:45626 +xref: Wikipedia:Systemic_venous_system is_a: UBERON:0002049 ! vasculature relationship: BFO:0000050 UBERON:0004582 ! part of venous system [Term] id: UBERON:0004582 name: venous system +def: "The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0004692 +xref: EHDAA2:0002171 +xref: EHDAA:486 +xref: EMAPA:16240 +xref: MA:0002720 +xref: NCIT:C33858 +xref: SCTID:362060003 +xref: VHOG:0000277 is_a: UBERON:0007798 ! vascular system relationship: RO:0002473 UBERON:0001638 ! vein -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004590 +name: sphincter muscle +def: "A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [Wikipedia:Sphincter] +xref: FMA:75004 +xref: NCIT:C28381 +xref: Wikipedia:Sphincter +is_a: UBERON:0001630 ! muscle organ [Term] id: UBERON:0004638 name: blood vessel endothelium +def: "An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0000766 +xref: CALOHA:TS-2155 +xref: EMAPA:35176 +xref: MA:0000709 +xref: NCIT:C53395 +xref: TAO:0005257 +xref: ZFA:0005257 is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004647 +name: liver lobule +def: "The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein." [ISBN:0-683-40008-8, MP:0008987] +xref: EMAPA:35499 +xref: FMA:14471 +xref: MA:0002494 +xref: NCIT:C32732 +xref: SCTID:362194004 +xref: Wikipedia:Lobules_of_liver +is_a: UBERON:0000064 ! organ part +is_a: UBERON:0004119 ! endoderm-derived structure +relationship: BFO:0000050 UBERON:0001280 ! part of liver parenchyma +relationship: BFO:0000051 CL:0000182 ! has part hepatocyte +relationship: RO:0002433 UBERON:0001280 ! liver parenchyma [Term] id: UBERON:0004663 name: aorta wall +def: "An anatomical wall that is part of an aorta, enclosing the luminal space." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:35139 +xref: FMA:14156 +xref: MA:0002901 is_a: UBERON:0035965 ! wall of blood vessel intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta @@ -38505,6 +57642,11 @@ relationship: RO:0002433 UBERON:0000947 ! aorta [Term] id: UBERON:0004664 name: aorta tunica adventitia +def: "The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers." [ISBN:0-683-40008-8, MP:0009871] +xref: EMAPA:35136 +xref: FMA:14283 +xref: MA:0002902 +xref: SCTID:24996002 is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta @@ -38514,6 +57656,13 @@ relationship: RO:0002433 UBERON:0004663 ! aorta wall [Term] id: UBERON:0004666 name: interventricular septum membranous part +def: "The membranous portion of the wall between the two lower chambers of the heart." [MP:0008823] +xref: EHDAA2:0004596 +xref: EMAPA:18246 +xref: FMA:7135 +xref: MA:0002939 +xref: SCTID:278228007 +xref: VHOG:0000927 is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0005983 ! heart layer is_a: UBERON:0010313 ! neural crest-derived structure @@ -38526,6 +57675,13 @@ relationship: RO:0002433 UBERON:0002094 ! interventricular septum [Term] id: UBERON:0004667 name: interventricular septum muscular part +def: "The muscular portion of the wall between the two lower chambers of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Interventricular_septum#Portions] +xref: EHDAA2:0000885 +xref: EHDAA:2607 +xref: EMAPA:18247 +xref: FMA:7134 +xref: MA:0002940 +xref: RETIRED_EHDAA2:0000888 is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum @@ -38535,6 +57691,19 @@ relationship: RO:0002433 UBERON:0002094 ! interventricular septum [Term] id: UBERON:0004684 name: raphe nuclei +def: "The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane." [https://sourceforge.net/tracker/?func=detail&aid=3248146&group_id=36855&atid=440764, NLXANAT:20090205] +comment: we treat NR obscurus, NR magnus etc as parts of the raphe nuclei. This is consistent with treatment in FMA, where the class is 'set of raphe nuclei' +xref: BAMS:RA +xref: EMAPA:35721 +xref: FMA:84017 +xref: MA:0003147 +xref: MESH:D011903 +xref: NCIT:C97335 +xref: neuronames:2495 +xref: NLXANAT:20090205 +xref: TAO:0001429 +xref: Wikipedia:Raphe_nuclei +xref: ZFA:0001429 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002275 ! part of reticular formation relationship: RO:0002215 GO:0001820 ! capable of serotonin secretion @@ -38542,13 +57711,20 @@ relationship: RO:0002215 GO:0001820 ! capable of serotonin secretion [Term] id: UBERON:0004688 name: costo-cervical trunk +def: "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]." [Wikipedia:Costocervical_trunk] +xref: FMA:10636 +xref: MA:0001939 +xref: SCTID:244225009 +xref: Wikipedia:Costocervical_trunk is_a: UBERON:0001637 ! artery relationship: RO:0002170 UBERON:0001533 ! subclavian artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004695 name: arterial system smooth muscle +def: "A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36503 +xref: MA:0000704 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0004572 ! part of arterial system @@ -38557,6 +57733,9 @@ relationship: BFO:0000050 UBERON:0004572 ! part of arterial system [Term] id: UBERON:0004696 name: venous system smooth muscle +def: "A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36613 +xref: MA:0000715 is_a: UBERON:0004237 ! blood vessel smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0004582 ! part of venous system @@ -38566,6 +57745,9 @@ relationship: BFO:0000050 UBERON:0004582 ! part of venous system [Term] id: UBERON:0004698 name: vena cava endothelium +def: "An endothelium that is part of a vena cava [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000713 +xref: NCIT:C49318 is_a: UBERON:0001919 ! endothelium of vein intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004087 ! part of vena cava @@ -38574,6 +57756,9 @@ relationship: BFO:0000050 UBERON:0004087 ! part of vena cava [Term] id: UBERON:0004699 name: outflow tract endothelium +def: "An endothelium that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000490 +xref: VHOG:0001524 is_a: UBERON:0008307 ! heart endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract @@ -38582,6 +57767,10 @@ relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract [Term] id: UBERON:0004700 name: arterial system endothelium +def: "An endothelium that is part of an arterial system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35145 +xref: MA:0000703 +xref: NCIT:C49329 is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004572 ! part of arterial system @@ -38590,6 +57779,10 @@ relationship: BFO:0000050 UBERON:0004572 ! part of arterial system [Term] id: UBERON:0004701 name: venous system endothelium +def: "An endothelium that is part of a venous system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35907 +xref: MA:0000714 +xref: NCIT:C49320 is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004582 ! part of venous system @@ -38598,6 +57791,9 @@ relationship: BFO:0000050 UBERON:0004582 ! part of venous system [Term] id: UBERON:0004702 name: respiratory system blood vessel endothelium +def: "A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35732 +xref: MA:0001805 is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004807 ! respiratory system epithelium intersection_of: UBERON:0004638 ! blood vessel endothelium @@ -38607,12 +57803,23 @@ relationship: BFO:0000050 UBERON:0003504 ! part of respiratory system blood vess [Term] id: UBERON:0004706 name: bulbus cordis +def: "A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches." [ISBN:0-683-40008-8, MP:0010568] +xref: EHDAA2:0000197 +xref: EHDAA:438 +xref: EHDAA:768 +xref: EMAPA:16333 +xref: FMA:70300 +xref: NCIT:C34114 +xref: SCTID:361525002 +xref: Wikipedia:Bulbus_cordis is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: UBERON:0004708 name: paired limb/fin +def: "An appendage that is part of an appendage girdle complex." [https://github.com/geneontology/go-ontology/issues/9029, UBERON:cjm] +xref: VSAO:0000067 is_a: UBERON:0000026 ! appendage intersection_of: UBERON:0000026 ! appendage intersection_of: BFO:0000050 UBERON:0010707 ! part of appendage girdle complex @@ -38628,6 +57835,9 @@ relationship: RO:0002551 UBERON:0011582 ! paired limb/fin skeleton [Term] id: UBERON:0004710 name: pectoral appendage +def: "Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues." [VSAO:0000150-modified] +xref: VHOG:0001753 +xref: VSAO:0000125 is_a: UBERON:0004708 ! paired limb/fin intersection_of: UBERON:0004708 ! paired limb/fin intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex @@ -38639,6 +57849,16 @@ relationship: RO:0002551 UBERON:0007272 ! pectoral appendage skeleton [Term] id: UBERON:0004711 name: jugular vein +def: "The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava." [Wikipedia:Jugular_vein] +xref: BTO:0001744 +xref: CALOHA:TS-0497 +xref: EMAPA:18638 +xref: GAID:536 +xref: MA:0002154 +xref: MESH:D007601 +xref: NCIT:C12738 +xref: SCTID:244403000 +xref: Wikipedia:Jugular_vein is_a: UBERON:0001638 ! vein relationship: BFO:0000050 UBERON:0000974 {gci_filler="NCBITaxon:8287", gci_relation="RO:0002162"} ! part of neck relationship: RO:0002179 UBERON:0000033 ! head @@ -38646,6 +57866,14 @@ relationship: RO:0002179 UBERON:0000033 ! head [Term] id: UBERON:0004716 name: conceptus +def: "The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]." [BTO:0003834, Wikipedia:Conceptus] +xref: AEO:0000194 +xref: BTO:0003834 +xref: EHDAA2:0000001 +xref: EHDAA2:0003235 +xref: EMAPA:36040 +xref: NCIT:C34131 +xref: Wikipedia:Conceptus is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000051 UBERON:0002050 ! has part embryonic structure relationship: BFO:0000051 UBERON:0016887 ! has part entire extraembryonic component @@ -38656,6 +57884,11 @@ relationship: RO:0002493 UBERON:0000068 ! embryo stage [Term] id: UBERON:0004731 name: neuromere +def: "A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres)." [DOI:10.1016/j.tins.2013.06.004, https://github.com/obophenotype/uberon/issues/318] +xref: NLX:147842 +xref: TAO:0001328 +xref: Wikipedia:Neuromere +xref: ZFA:0001328 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: UBERON:0004732 ! segmental subdivision of nervous system @@ -38665,6 +57898,7 @@ relationship: BFO:0000050 UBERON:0001049 ! part of neural tube [Term] id: UBERON:0004732 name: segmental subdivision of nervous system +def: "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres." [FBbt:00005140, http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000063 ! organ subunit intersection_of: UBERON:0000063 ! organ subunit intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system @@ -38673,6 +57907,8 @@ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system [Term] id: UBERON:0004733 name: segmental subdivision of hindbrain +def: "An organ subunit that is part of a hindbrain [Automatically generated definition]." [OBOL:automatic] +xref: FMA:61998 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: UBERON:0000063 ! organ subunit @@ -38682,6 +57918,17 @@ relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain [Term] id: UBERON:0004734 name: gastrula +def: "Organism at the gastrula stage." [Wikipedia:Gastrula, Wikipedia:Trilaminar_blastocyst] +xref: BILA:0000060 +xref: BTO:0001403 +xref: FMA:293108 +xref: GAID:1302 +xref: MESH:D005775 +xref: MIAA:0000179 +xref: NCIT:C34057 +xref: NCIT:C34058 +xref: Wikipedia:Gastrula +xref: Wikipedia:Trilaminar_blastocyst is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002491 UBERON:0000109 ! gastrula stage @@ -38691,6 +57938,13 @@ relationship: RO:0002491 UBERON:0000109 ! gastrula stage [Term] id: UBERON:0004755 name: skeletal tissue +def: "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/134, PSPUB:0000170, VSAO:0000015] +comment: Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from +xref: MA:0003047 +xref: SCTID:309311006 +xref: VSAO:0000015 +xref: XAO:0004038 +xref: ZFA:0005619 is_a: UBERON:0002384 ! connective tissue relationship: BFO:0000050 UBERON:0004765 ! part of skeletal element relationship: RO:0002202 CL:0007001 ! skeletogenic cell @@ -38698,6 +57952,7 @@ relationship: RO:0002202 CL:0007001 ! skeletogenic cell [Term] id: UBERON:0004756 name: dermal skeletal element +def: "Dermis-derived entity that is made of skeletal tissue." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/206] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004765 ! skeletal element intersection_of: UBERON:0004765 ! skeletal element @@ -38706,9 +57961,35 @@ intersection_of: RO:0002202 UBERON:0002067 ! dermis relationship: BFO:0000051 UBERON:0004755 ! has part skeletal tissue relationship: RO:0002202 UBERON:0002067 ! dermis +[Term] +id: UBERON:0004760 +name: gland of anal canal +def: "A gland that is part of an anal canal [Automatically generated definition]." [OBOL:automatic, Wikipedia:Anal_gland] +xref: EMAPA:27221 +xref: EMAPA:27233 +xref: EMAPA:27543 +xref: FMA:15720 +xref: FMA:15724 +xref: NCIT:C32068 +xref: SCTID:245448005 +xref: Wikipedia:Anal_gland +is_a: UBERON:0003408 ! gland of digestive tract +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0002530 ! gland +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal + [Term] id: UBERON:0004761 name: cartilaginous neurocranium +def: "The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]." [Wikipedia:Chondrocranium] +xref: AAO:0000094 +xref: EHDAA:6031 +xref: FMA:76621 +xref: NCIT:C34121 +xref: SCTID:155540009 +xref: Wikipedia:Chondrocranium +xref: XAO:0003059 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000051 UBERON:0002418 ! has part cartilage tissue relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -38717,6 +57998,9 @@ relationship: RO:0002202 UBERON:0009617 ! head paraxial mesoderm [Term] id: UBERON:0004764 name: intramembranous bone tissue +def: "Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]." [GO:0001957, Wikipedia:Intramembranous_ossification] +xref: MA:0002837 +xref: Wikipedia:Intramembranous_ossification is_a: UBERON:0002481 ! bone tissue intersection_of: UBERON:0002481 ! bone tissue intersection_of: RO:0002353 GO:0001957 ! output of intramembranous ossification @@ -38727,21 +58011,30 @@ relationship: RO:0002353 GO:0001957 ! output of intramembranous ossification [Term] id: UBERON:0004765 name: skeletal element +def: "Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0011129 +xref: galen:SkeletalStructure +xref: TAO:0001890 +xref: VSAO:0000128 +xref: XAO:0004012 +xref: ZFA:0005494 is_a: UBERON:0000062 ! organ relationship: BFO:0000050 UBERON:0001434 ! part of skeletal system [Term] id: UBERON:0004766 name: cranial bone +def: "A bone that is part of a cranium." [UBERON:automatic] +xref: SCTID:181792001 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0003128 ! part of cranium relationship: BFO:0000050 UBERON:0003128 ! part of cranium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004768 name: bone of lower jaw +def: "Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0012360 ! bone of jaw intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region @@ -38750,6 +58043,12 @@ relationship: BFO:0000050 UBERON:0003278 ! part of skeleton of lower jaw [Term] id: UBERON:0004770 name: articular system +def: "Anatomical system that consists of all the joints of the body." [VSAO:0000181] +xref: EMAPA:35150 +xref: FMA:23878 +xref: MA:0003007 +xref: SCTID:361827000 +xref: VSAO:0000181 is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: RO:0002351 UBERON:0000982 ! skeletal joint @@ -38762,6 +58061,8 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0004777 name: respiratory system submucosa +def: "A submucosa that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001822 is_a: UBERON:0000009 ! submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -38770,6 +58071,8 @@ relationship: BFO:0000050 UBERON:0003570 ! part of respiratory system connective [Term] id: UBERON:0004779 name: respiratory system lamina propria +def: "A lamina propria that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001821 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -38779,22 +58082,59 @@ relationship: BFO:0000050 UBERON:0004785 ! part of respiratory system mucosa [Term] id: UBERON:0004780 name: gastrointestinal system lamina propria +def: "A lamina propria that is part of a gastrointestinal system." [OBOL:automatic] +xref: MA:0001899 +xref: NCIT:C49299 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0004786 ! part of gastrointestinal system mucosa +[Term] +id: UBERON:0004781 +name: gallbladder lamina propria +def: "A lamina propria that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35371 +xref: FMA:278594 +xref: MA:0001633 +xref: NCIT:C49228 +is_a: UBERON:0000030 ! lamina propria +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0005033 ! part of mucosa of gallbladder + [Term] id: UBERON:0004782 name: gastrointestinal system serosa +def: "A serous membrane that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001522 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system +[Term] +id: UBERON:0004783 +name: gallbladder serosa +def: "A serous membrane that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35372 +xref: FMA:14659 +xref: MA:0001634 +xref: SCTID:362197006 +is_a: UBERON:0000042 ! serous membrane +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder + [Term] id: UBERON:0004784 name: heart ventricle wall +def: "An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]." [OBOL:automatic] +xref: FMA:13884 +xref: MA:0002791 +xref: NCIT:C119295 is_a: UBERON:0037144 ! wall of heart intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -38803,6 +58143,12 @@ relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle [Term] id: UBERON:0004785 name: respiratory system mucosa +def: "The mucous membrane lining the respiratory tract." [MESH:A04.760, MGI:cwg, MP:0002277] +xref: BTO:0000973 +xref: FMA:302092 +xref: GAID:304 +xref: MA:0001827 +xref: MESH:D020545 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -38811,6 +58157,13 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0004786 name: gastrointestinal system mucosa +def: "A mucosa that is part of a gastrointestinal system." [OBOL:automatic] +comment: The gut mucosa of amphioxus has insulin-secreting cells. http://www.ncbi.nlm.nih.gov/pubmed/16417468 +xref: BTO:0000546 +xref: BTO:0005568 +xref: EMAPA:36591 +xref: MA:0001521 +xref: SCTID:410433007 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system @@ -38821,17 +58174,69 @@ relationship: BFO:0000051 CL:0000696 ! has part PP cell relationship: BFO:0000051 CL:0002067 ! has part type A enteroendocrine cell relationship: RO:0002220 UBERON:0006909 ! adjacent to lumen of digestive tract +[Term] +id: UBERON:0004790 +name: skin mucous gland +def: "A mucous gland that is part of the skin." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:35775 +xref: MA:0000148 +is_a: UBERON:0000414 ! mucous gland +is_a: UBERON:0007771 ! epidermis gland +is_a: UBERON:0019319 ! exocrine gland of integumental system +intersection_of: UBERON:0000414 ! mucous gland +intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body + +[Term] +id: UBERON:0004792 +name: secretion of endocrine pancreas +def: "A secretion that is part of a endocrine pancreas [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002517 +xref: NCIT:C33255 +is_a: UBERON:0004795 ! pancreas secretion +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: BFO:0000050 UBERON:0000016 ! part of endocrine pancreas +relationship: BFO:0000050 UBERON:0000016 ! part of endocrine pancreas + +[Term] +id: UBERON:0004793 +name: secretion of exocrine pancreas +def: "A secretion that is part of a exocrine pancreas [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002518 +xref: NCIT:C33256 +is_a: UBERON:0004795 ! pancreas secretion +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas + [Term] id: UBERON:0004794 name: esophagus secretion +def: "A secretion that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: FMA:79662 +xref: MA:0002514 +xref: NCIT:C52555 is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus +[Term] +id: UBERON:0004795 +name: pancreas secretion +def: "A secretion that is part of a pancreas [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002516 +xref: NCIT:C13270 +is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: UBERON:0004797 name: blood vessel layer +def: "Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:36296 +xref: MA:0002854 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -38841,6 +58246,12 @@ relationship: BFO:0000050 UBERON:0035965 ! part of wall of blood vessel [Term] id: UBERON:0004802 name: respiratory tract epithelium +def: "The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi." [ISBN:0-683-40008-8, MGI:anna, MP:0010942] +xref: BTO:0000419 +xref: CALOHA:TS-0023 +xref: EMAPA:32827 +xref: MA:0001480 +xref: SCTID:321764001 is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0010499 ! pseudostratified ciliated columnar epithelium @@ -38852,6 +58263,10 @@ relationship: RO:0002433 UBERON:0001004 ! respiratory system [Term] id: UBERON:0004807 name: respiratory system epithelium +def: "An epithelium that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: CALOHA:TS-0023 +xref: EMAPA:32826 +xref: MA:0001823 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -38860,6 +58275,9 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0004808 name: gastrointestinal system epithelium +def: "An epithelium that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:32683 +xref: MA:0001520 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system @@ -38868,14 +58286,37 @@ relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointe [Term] id: UBERON:0004815 name: lower respiratory tract epithelium +def: "An epithelium that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001481 is_a: UBERON:0004802 ! respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract +[Term] +id: UBERON:0004820 +name: bile duct epithelium +def: "Any epithelium that lines one of the bile ducts." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000417 +xref: MA:0001629 +xref: NCIT:C43616 +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0034932 ! epithelium of biliary system +is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0002394 ! part of bile duct +relationship: BFO:0000050 UBERON:0002394 ! part of bile duct +relationship: BFO:0000051 CL:1000488 ! has part cholangiocyte + [Term] id: UBERON:0004821 name: pulmonary alveolus epithelium +def: "The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO]." [BTO:0003511, MP:0010898] +xref: BTO:0003511 +xref: EMAPA:35121 +xref: FMA:63915 +xref: MA:0001771 +xref: NCIT:C12867 is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0000487 ! simple squamous epithelium intersection_of: UBERON:0000483 ! epithelium @@ -38885,9 +58326,37 @@ relationship: BFO:0000051 CL:0002062 ! has part pulmonary alveolar type 1 cell relationship: RO:0002433 UBERON:0000115 ! lung epithelium relationship: RO:0002433 UBERON:0002299 ! alveolus of lung +[Term] +id: UBERON:0004822 +name: extrahepatic bile duct epithelium +def: "An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000742 +xref: EHDAA:3051 +xref: MA:0002661 +xref: NCIT:C43618 +is_a: UBERON:0004820 ! bile duct epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0003703 ! part of extrahepatic bile duct +relationship: BFO:0000050 UBERON:0003703 ! part of extrahepatic bile duct + +[Term] +id: UBERON:0004823 +name: intrahepatic bile duct epithelium +def: "An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000743 +xref: EHDAA:3053 +xref: MA:0002662 +xref: NCIT:C43617 +is_a: UBERON:0004820 ! bile duct epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0003704 ! part of intrahepatic bile duct +relationship: BFO:0000050 UBERON:0003704 ! part of intrahepatic bile duct + [Term] id: UBERON:0004830 name: respiratory system skeletal muscle +def: "A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001829 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -38896,42 +58365,78 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0004831 name: esophagus skeletal muscle +def: "A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +comment: Most muscle tissue lining the digestive tract is smooth, but part of the externa of the esophagus is skeletal +xref: EMAPA:36523 +xref: MA:0001572 is_a: UBERON:0003898 ! skeletal muscle tissue of trunk intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0003832 ! part of esophagus muscle +[Term] +id: UBERON:0004832 +name: anal region skeletal muscle +def: "A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001530 +is_a: UBERON:0001134 ! skeletal muscle tissue +intersection_of: UBERON:0001134 ! skeletal muscle tissue +intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region +relationship: BFO:0000050 UBERON:0001353 ! part of anal region + [Term] id: UBERON:0004833 name: lip skeletal muscle +def: "A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001578 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001833 ! part of lip relationship: BFO:0000050 UBERON:0001833 ! part of lip +[Term] +id: UBERON:0004834 +name: hepatic duct smooth muscle +def: "Smooth muscle tissue in all or part of a hepatic duct." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0001640 +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0005171 ! part of hepatic duct +relationship: BFO:0000050 UBERON:0005171 ! part of hepatic duct + [Term] id: UBERON:0004848 name: respiratory system arterial endothelium +def: "An endothelium of artery that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001801 is_a: UBERON:0001917 ! endothelium of artery is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001917 ! endothelium of artery intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003469 ! part of respiratory system artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004849 name: respiratory system venous endothelium +def: "An endothelium of vein that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001811 is_a: UBERON:0001919 ! endothelium of vein is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001919 ! endothelium of vein intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003476 ! part of respiratory system venous blood vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004851 name: aorta endothelium +def: "The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall." [MGI:csmith, MP:0009864] +xref: BTO:0000394 +xref: CALOHA:TS-0047 +xref: EFO:0002597 +xref: EMAPA:35134 +xref: MA:0000701 +xref: NCIT:C49190 is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004700 ! arterial system endothelium intersection_of: UBERON:0001986 ! endothelium @@ -38941,14 +58446,37 @@ relationship: BFO:0000050 UBERON:0000947 ! part of aorta [Term] id: UBERON:0004852 name: cardiovascular system endothelium +def: "An endothelium that is part of the cardiovascular system." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0001853 +xref: EMAPA:35201 +xref: GAID:519 +xref: MA:0000717 +xref: MESH:D004730 +xref: NCIT:C13053 +xref: TAO:0002171 +xref: VHOG:0001217 +xref: XAO:0000356 +xref: ZFA:0001639 is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004535 ! part of cardiovascular system relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system +[Term] +id: UBERON:0004854 +name: gastrointestinal system mesentery +def: "A mesentery that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001900 +is_a: UBERON:0002095 ! mesentery +is_a: UBERON:0004782 ! gastrointestinal system serosa +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system + [Term] id: UBERON:0004857 name: skeletal muscle connective tissue +def: "A connective tissue that surrounds a skeletal muscle tissue." [OBOL:automatic] +xref: MA:0002868 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002221 UBERON:0001134 ! skeletal muscle tissue @@ -38957,6 +58485,10 @@ relationship: RO:0002221 UBERON:0001134 ! skeletal muscle tissue [Term] id: UBERON:0004859 name: eye gland +def: "A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid." [http://orcid.org/0000-0002-6601-2165] +comment: Examples: harderian gland, accessory lacrimal gland, gland of Moll, gland of Zeis, nictitating membrane glands +xref: EMAPA:35334 +xref: MA:0000267 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000970 ! part of eye @@ -38965,6 +58497,10 @@ relationship: BFO:0000050 UBERON:0000970 ! part of eye [Term] id: UBERON:0004861 name: right lung alveolus +def: "An alveolus that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35997 +xref: MA:0001786 +xref: NCIT:C49278 is_a: UBERON:0002299 ! alveolus of lung intersection_of: UBERON:0003215 ! alveolus intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -38973,6 +58509,10 @@ relationship: BFO:0000050 UBERON:0006526 ! part of right lung alveolar system [Term] id: UBERON:0004862 name: left lung alveolus +def: "An alveolus that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:19182 +xref: MA:0001777 +xref: NCIT:C49251 is_a: UBERON:0002299 ! alveolus of lung intersection_of: UBERON:0003215 ! alveolus intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung @@ -38981,22 +58521,52 @@ relationship: BFO:0000050 UBERON:0006525 ! part of left lung alveolar system [Term] id: UBERON:0004864 name: vasculature of retina +def: "A vasculature that is part of a retina [Automatically generated definition]." [OBOL:automatic] +xref: FMA:76552 +xref: MESH:D012171 is_a: UBERON:0002203 ! vasculature of eye is_a: UBERON:0036302 ! vasculature of central nervous system plus retina intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000966 ! part of retina relationship: BFO:0000050 UBERON:0000966 ! part of retina -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004867 +name: orbital cavity +def: "Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000343 +xref: FMA:84961 +xref: SCTID:280541000 +xref: Wikipedia:Orbit_(anatomy) +xref: ZFA:0005558 +is_a: UBERON:0002553 ! anatomical cavity +intersection_of: UBERON:0002553 ! anatomical cavity +intersection_of: RO:0002572 UBERON:0001697 ! orbit of skull +relationship: RO:0002572 UBERON:0001697 ! orbit of skull [Term] id: UBERON:0004872 name: splanchnic layer of lateral plate mesoderm +def: "Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]." [Wikipedia:Lateral_plate_mesoderm#Division_into_layers] +xref: AAO:0011102 +xref: BILA:0000044 +xref: FMA:295568 +xref: Wikipedia:Lateral_plate_mesoderm#Division_into_layers +xref: XAO:0000276 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm [Term] id: UBERON:0004873 name: splanchnopleure +def: "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]." [Wikipedia:Splanchnopleure] +xref: EHDAA2:0001903 +xref: EHDAA:383 +xref: EMAPA:16181 +xref: FMA:295564 +xref: NCIT:C34303 +xref: VHOG:0000558 +xref: Wikipedia:Splanchnopleure is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm relationship: RO:0002131 UBERON:0000925 ! overlaps endoderm @@ -39004,6 +58574,14 @@ relationship: RO:0002131 UBERON:0000925 ! overlaps endoderm [Term] id: UBERON:0004874 name: somatopleure +def: "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]." [Wikipedia:Somatopleure] +xref: EHDAA2:0001847 +xref: EHDAA:381 +xref: EMAPA:16180 +xref: FMA:295566 +xref: NCIT:C34301 +xref: VHOG:0000557 +xref: Wikipedia:Somatopleure is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm relationship: RO:0002131 UBERON:0000924 ! overlaps ectoderm @@ -39011,6 +58589,11 @@ relationship: RO:0002131 UBERON:0000924 ! overlaps ectoderm [Term] id: UBERON:0004880 name: chordamesoderm +def: "The central region of trunk mesoderm. This tissue forms the notochord." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0000478 +xref: EFO:0003426 +xref: TAO:0000091 +xref: ZFA:0000091 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003068 ! part of axial mesoderm relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -39018,17 +58601,24 @@ relationship: RO:0002160 NCBITaxon:7711 ! Chordata [Term] id: UBERON:0004883 name: lung mesenchyme +def: "The mass of tissue made up of mesenchymal cells in the lung." [GO:0060484] +xref: EMAPA:32866 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002202 UBERON:0003081 ! lateral plate mesoderm -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004893 name: interalveolar septum +def: "A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung." [LG:0012625, Wikipedia:Alveolar_septum] +xref: BTO:0003149 +xref: EMAPA:35433 +xref: MA:0000421 +xref: NCIT:C49473 +xref: Wikipedia:Alveolar_septum is_a: UBERON:0003037 ! septum is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0003037 ! septum @@ -39039,6 +58629,13 @@ relationship: RO:0002220 UBERON:0002299 ! adjacent to alveolus of lung [Term] id: UBERON:0004894 name: alveolar wall +def: "A wall that contains the alveoli." [LG:0012626, MP:0010903] +xref: BTO:0002543 +xref: EMAPA:35120 +xref: FMA:14117 +xref: MA:0002568 +xref: NCIT:C13085 +xref: SCTID:361965008 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall @@ -39049,6 +58646,9 @@ relationship: RO:0002433 UBERON:0002299 ! alveolus of lung [Term] id: UBERON:0004895 name: alveolar smooth muscle +def: "Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus." [LG:0012628] +xref: EMAPA:35122 +xref: MA:0002759 is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002299 ! part of alveolus of lung @@ -39057,6 +58657,11 @@ relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung [Term] id: UBERON:0004904 name: neuron projection bundle connecting eye with brain +def: "A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila." [http://orcid.org/0000-0002-6601-2165] +comment: for the vertebrate-specific structure, see UBERON:0000941 (cranial nerve II) +xref: BTO:0000966 +xref: EV:0100351 +xref: TADS:0000232 is_a: UBERON:0000122 ! neuron projection bundle intersection_of: UBERON:0000122 ! neuron projection bundle intersection_of: extends_fibers_into UBERON:0000955 ! brain @@ -39064,32 +58669,56 @@ intersection_of: extends_fibers_into UBERON:0005388 ! photoreceptor array relationship: BFO:0000050 UBERON:0002104 ! part of visual system relationship: extends_fibers_into UBERON:0000955 ! brain relationship: extends_fibers_into UBERON:0005388 ! photoreceptor array -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004905 name: articulation +def: "Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0004770 ! part of articular system [Term] id: UBERON:0004906 name: ectodermal part of digestive tract +def: "A portion of the gut that is derived from ectoderm." [GO:0007439] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract intersection_of: RO:0002202 UBERON:0000924 ! ectoderm +[Term] +id: UBERON:0004907 +name: lower digestive tract +def: "The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]." [Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract] +xref: FMA:49179 +xref: galen:LowerGastrointestinalTract +xref: NCIT:C33010 +xref: SCTID:279973004 +xref: Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system +relationship: RO:0002202 UBERON:0001046 ! hindgut + [Term] id: UBERON:0004908 name: upper digestive tract +def: "The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum." [Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract] +xref: FMA:49177 +xref: galen:UpperGastrointestinalTract +xref: NCIT:C33837 +xref: SCTID:181244000 +xref: Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract is_a: UBERON:0004921 ! subdivision of digestive tract relationship: RO:0002202 UBERON:0001041 ! foregut [Term] id: UBERON:0004909 name: epithelium of gonad +def: "An epithelium surrounding a gonad." [OBOL:automatic] +xref: EHDAA:4032 +xref: EHDAA:5931 +xref: NCIT:C32676 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000483 ! epithelium @@ -39099,24 +58728,104 @@ relationship: BFO:0000050 UBERON:0000991 ! part of gonad [Term] id: UBERON:0004911 name: epithelium of female gonad +def: "An epithelium surrounding an ovary." [OBOL:automatic] +xref: BTO:0003661 is_a: UBERON:0004909 ! epithelium of gonad intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary +[Term] +id: UBERON:0004912 +name: biliary bud +xref: EHDAA2:0000171 +xref: EMAPA:16561 +xref: EMAPA_RETIRED:16565 +xref: VHOG:0001351 +is_a: UBERON:0004185 ! endodermal part of digestive tract +is_a: UBERON:0007499 ! epithelial sac +is_a: UBERON:0009497 ! epithelium of foregut-midgut junction +is_a: UBERON:0009854 ! digestive tract diverticulum +relationship: BFO:0000050 UBERON:0002423 ! part of hepatobiliary system +relationship: RO:0002202 UBERON:0004161 ! septum transversum + +[Term] +id: UBERON:0004913 +name: hepatopancreatic ampulla +def: "A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct." [Wikipedia:Ampulla_of_Vater] +xref: CALOHA:TS-2348 +xref: FMA:15076 +xref: GAID:283 +xref: galen:AmpullaOfVater +xref: MESH:D014670 +xref: NCIT:C13011 +xref: SCTID:362200007 +xref: TAO:0005167 +xref: Wikipedia:Ampulla_of_Vater +xref: ZFA:0005167 +is_a: UBERON:0002394 ! bile duct +intersection_of: UBERON:0000058 ! duct +intersection_of: BFO:0000050 UBERON:0001174 ! part of common bile duct +intersection_of: BFO:0000050 UBERON:0004914 ! part of duodenal papilla +relationship: BFO:0000050 UBERON:0001174 ! part of common bile duct +relationship: BFO:0000050 UBERON:0004914 ! part of duodenal papilla + +[Term] +id: UBERON:0004914 +name: duodenal papilla +def: "One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct." [http://medical-dictionary.thefreedictionary.com/duodenal+papilla] +xref: EMAPA:18662 +xref: FMA:15953 +xref: MA:0003107 +xref: NCIT:C119578 +xref: SCTID:245389007 +is_a: UBERON:0034944 ! zone of organ +relationship: BFO:0000050 UBERON:0000320 ! part of duodenal mucosa + +[Term] +id: UBERON:0004915 +name: sphincter of hepatopancreatic ampulla +def: "Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]." [Wikipedia:Sphincter_of_ampulla] +xref: EMAPA:18663 +xref: FMA:15077 +xref: GAID:285 +xref: MESH:D009803 +xref: NCIT:C13065 +xref: SCTID:181271000 +xref: Wikipedia:Sphincter_of_ampulla +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0011185 ! gastrointestinal sphincter +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0004913 ! part of hepatopancreatic ampulla +relationship: BFO:0000050 UBERON:0004913 ! part of hepatopancreatic ampulla + +[Term] +id: UBERON:0004916 +name: anal sphincter +def: "A sphincter muscle that is part of a anal region." [OBOL:automatic] +xref: EMAPA:36052 +is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region +relationship: BFO:0000050 UBERON:0001353 ! part of anal region +relationship: RO:0002216 GO:0030421 ! capable of part of defecation + [Term] id: UBERON:0004921 name: subdivision of digestive tract +def: "A proximal-distal subdivision of the digestive tract." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:71131 is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: subdivision_of UBERON:0001555 ! digestive tract relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: subdivision_of UBERON:0001555 ! digestive tract -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004923 name: organ component layer +def: "A part of a wall of an organ that forms a layer." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:82485 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000060 ! part of anatomical wall relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa @@ -39124,32 +58833,276 @@ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0004924 name: submucosa of pharynx +def: "The tissue underlying the tunica mucosa of the pharynx." [BTO:0002113] +xref: BTO:0002113 +xref: FMA:75144 +xref: SCTID:19594009 is_a: UBERON:0004777 ! respiratory system submucosa is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx +[Term] +id: UBERON:0004926 +name: submucosa of cystic duct +def: "A submucosa that is part of a cystic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18013 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001152 ! part of cystic duct +relationship: BFO:0000050 UBERON:0001152 ! part of cystic duct + +[Term] +id: UBERON:0004932 +name: submucosa of sigmoid colon +def: "A submucosa that is part of a sigmoid colon [Automatically generated definition]." [OBOL:automatic] +xref: FMA:15027 +is_a: UBERON:0003331 ! submucosa of colon +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon +relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon + +[Term] +id: UBERON:0004934 +name: submucosa of body of stomach +def: "A submucosa that is part of a body of stomach [Automatically generated definition]." [OBOL:automatic] +xref: FMA:17059 +is_a: UBERON:0001200 ! submucosa of stomach +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001161 ! part of body of stomach +relationship: BFO:0000050 UBERON:0001161 ! part of body of stomach + +[Term] +id: UBERON:0004936 +name: submucosa of pyloric antrum +def: "A submucosa that is part of a pyloric antrum [Automatically generated definition]." [OBOL:automatic] +xref: FMA:17060 +is_a: UBERON:0004937 ! submucosa of pylorus +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001165 ! part of pyloric antrum +relationship: BFO:0000050 UBERON:0001165 ! part of pyloric antrum + +[Term] +id: UBERON:0004937 +name: submucosa of pylorus +def: "A submucosa that is part of a pylorus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27201 +xref: FMA:17462 +is_a: UBERON:0001200 ! submucosa of stomach +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus + +[Term] +id: UBERON:0004938 +name: submucosa of biliary tree +def: "A submucosa that is part of a biliary tree [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18009 +is_a: UBERON:0000009 ! submucosa +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001173 ! part of biliary tree +relationship: BFO:0000050 UBERON:0001173 ! part of biliary tree + +[Term] +id: UBERON:0004939 +name: submucosa of common bile duct +def: "A submucosa that is part of a common bile duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18011 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001174 ! part of common bile duct +relationship: BFO:0000050 UBERON:0001174 ! part of common bile duct + +[Term] +id: UBERON:0004940 +name: submucosa of common hepatic duct +def: "A submucosa that is part of a common hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18014 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001175 ! part of common hepatic duct +relationship: BFO:0000050 UBERON:0001175 ! part of common hepatic duct + +[Term] +id: UBERON:0004941 +name: submucosa of right hepatic duct +def: "A submucosa that is part of a right hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18015 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001176 ! part of right hepatic duct +relationship: BFO:0000050 UBERON:0001176 ! part of right hepatic duct + +[Term] +id: UBERON:0004942 +name: submucosa of left hepatic duct +def: "A submucosa that is part of a left hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18017 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001177 ! part of left hepatic duct +relationship: BFO:0000050 UBERON:0001177 ! part of left hepatic duct + [Term] id: UBERON:0004952 name: submucosa of bronchiole +def: "A submucosa that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:62775 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0002186 ! part of bronchiole relationship: BFO:0000050 UBERON:0002186 ! part of bronchiole +[Term] +id: UBERON:0004988 +name: mucosa of cystic duct +def: "A mucosa that is part of a cystic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14690 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001152 ! part of cystic duct +relationship: BFO:0000050 UBERON:0001152 ! part of cystic duct + +[Term] +id: UBERON:0004993 +name: mucosa of sigmoid colon +def: "A mucosa that is part of a sigmoid colon [Automatically generated definition]." [OBOL:automatic] +xref: FMA:15026 +is_a: UBERON:0000317 ! colonic mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon +relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon + +[Term] +id: UBERON:0004995 +name: mucosa of body of stomach +def: "A mucosa that is part of a body of stomach [Automatically generated definition]." [OBOL:automatic] +xref: FMA:17054 +is_a: UBERON:0001199 ! mucosa of stomach +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001161 ! part of body of stomach +relationship: BFO:0000050 UBERON:0001161 ! part of body of stomach + +[Term] +id: UBERON:0004997 +name: mucosa of pyloric antrum +def: "A mucosa that is part of a pyloric antrum [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004107 +xref: FMA:17055 +is_a: UBERON:0004998 ! mucosa of pylorus +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001165 ! part of pyloric antrum +relationship: BFO:0000050 UBERON:0001165 ! part of pyloric antrum +relationship: BFO:0000050 UBERON:0004998 ! part of mucosa of pylorus + +[Term] +id: UBERON:0004998 +name: mucosa of pylorus +def: "A mucosa that is part of a pylorus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004110 +xref: EMAPA:27199 +xref: FMA:17461 +is_a: UBERON:0001199 ! mucosa of stomach +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus + +[Term] +id: UBERON:0004999 +name: mucosa of biliary tree +def: "A mucosa that is part of a biliary tree [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14695 +is_a: UBERON:0000344 ! mucosa +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001173 ! part of biliary tree +relationship: BFO:0000050 UBERON:0001173 ! part of biliary tree + +[Term] +id: UBERON:0005000 +name: mucosa of common bile duct +def: "A mucosa that is part of a common bile duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14688 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001174 ! part of common bile duct +relationship: BFO:0000050 UBERON:0001174 ! part of common bile duct + +[Term] +id: UBERON:0005001 +name: mucosa of common hepatic duct +def: "A mucosa that is part of a common hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14691 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001175 ! part of common hepatic duct +relationship: BFO:0000050 UBERON:0001175 ! part of common hepatic duct + +[Term] +id: UBERON:0005002 +name: mucosa of right hepatic duct +def: "A mucosa that is part of a right hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14692 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001176 ! part of right hepatic duct +relationship: BFO:0000050 UBERON:0001176 ! part of right hepatic duct + +[Term] +id: UBERON:0005003 +name: mucosa of left hepatic duct +def: "A mucosa that is part of a left hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14693 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001177 ! part of left hepatic duct +relationship: BFO:0000050 UBERON:0001177 ! part of left hepatic duct + +[Term] +id: UBERON:0005031 +name: mucosa of upper lip +def: "A mucosa that is part of a upper lip [Automatically generated definition]." [OBOL:automatic] +xref: FMA:59832 +xref: NCIT:C12224 +xref: SCTID:362088009 +is_a: UBERON:0036294 ! mucosa of lip +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001834 ! part of upper lip +relationship: BFO:0000050 UBERON:0001834 ! part of upper lip + [Term] id: UBERON:0005032 name: mucosa of lower lip +def: "A mucosa that is part of a lower lip [Automatically generated definition]." [OBOL:automatic] +xref: FMA:59833 +xref: NCIT:C12225 +xref: SCTID:362089001 is_a: UBERON:0036294 ! mucosa of lip intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001835 ! part of lower lip relationship: BFO:0000050 UBERON:0001835 ! part of lower lip +[Term] +id: UBERON:0005033 +name: mucosa of gallbladder +def: "A mucosa that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14662 +xref: SCTID:362196002 +is_a: UBERON:0000344 ! mucosa +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder + [Term] id: UBERON:0005039 name: mucosa of bronchiole +def: "A mucosa that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:62774 +xref: SCTID:10887006 is_a: UBERON:0000379 ! tracheal mucosa is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000344 ! mucosa @@ -39159,6 +59112,8 @@ relationship: BFO:0000050 UBERON:0002186 ! part of bronchiole [Term] id: UBERON:0005040 name: mucosa of terminal bronchiole +def: "A mucosa that is part of a terminal bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:263232 is_a: UBERON:0005039 ! mucosa of bronchiole intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole @@ -39167,6 +59122,8 @@ relationship: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole [Term] id: UBERON:0005041 name: mucosa of respiratory bronchiole +def: "A mucosa that is part of a respiratory bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:263238 is_a: UBERON:0005039 ! mucosa of bronchiole intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole @@ -39175,17 +59132,23 @@ relationship: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole [Term] id: UBERON:0005056 name: external female genitalia +def: "An external genitalia that is part of a female reproductive system [Automatically generated definition]." [OBOL:automatic] +comment: TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 +xref: BTO:0003100 +xref: EMAPA:30984 +xref: FMA:45649 +xref: galen:FemaleExternalGenitalia +xref: SCTID:362234008 is_a: UBERON:0003134 ! female reproductive organ is_a: UBERON:0004176 ! external genitalia intersection_of: UBERON:0004176 ! external genitalia intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system disjoint_from: UBERON:0009196 ! indifferent external genitalia -property_value: RO:0002175 NCBITaxon:50557 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005057 name: immune organ +def: "An organ that is part of a immune system [Automatically generated definition]." [OBOL:automatic] is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002405 ! part of immune system @@ -39194,6 +59157,9 @@ relationship: BFO:0000050 UBERON:0002405 ! part of immune system [Term] id: UBERON:0005058 name: hemolymphoid system gland +def: "A gland that is part of a hemolymphoid system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18766 +xref: MA:0002962 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system @@ -39202,12 +59168,29 @@ relationship: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system [Term] id: UBERON:0005061 name: neural groove +def: "The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds." [GO:0001842, http://orcid.org/0000-0002-6601-2165, Wikipedia:Neural_groove] +xref: AAO:0011071 +xref: EMAPA:35594 +xref: FMA:295624 +xref: NCIT:C34224 +xref: neuronames:1363 +xref: SCTID:361463007 +xref: Wikipedia:Neural_groove +xref: XAO:0000248 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003075 ! part of neural plate [Term] id: UBERON:0005062 name: neural fold +def: "One of the two elevated edges of the neural groove[GO,MP]." [GO:0001842, MP:0011256, Wikipedia:Neural_fold] +xref: EHDAA2:0001249 +xref: FMA:295618 +xref: NCIT:C34223 +xref: neuronames:1364 +xref: SCTID:361461009 +xref: Wikipedia:Neural_fold +xref: XAO:0004087 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005157 ! epithelial fold is_a: UBERON:0005291 ! embryonic tissue @@ -39216,15 +59199,38 @@ is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0005061 ! part of neural groove relationship: BSPO:0000126 UBERON:0005061 ! neural groove +[Term] +id: UBERON:0005064 +name: left ventricular trabecular myocardium +def: "Missing definition for term UBERON:0005064. Please replace it using linked reference." [GO:0003225] +is_a: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle +relationship: BFO:0000050 UBERON:0003382 ! part of cardiac muscle of left ventricle + +[Term] +id: UBERON:0005066 +name: right ventricular trabecular myocardium +def: "Missing definition for term UBERON:0005066. Please replace it using linked reference." [GO:0003227] +is_a: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle +relationship: BFO:0000050 UBERON:0003381 ! part of cardiac muscle of right ventricle + [Term] id: UBERON:0005068 name: neural rod +def: "A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]." [GO:0014024, ZFA:0000133] +xref: EFO:0003498 +xref: TAO:0000133 +xref: ZFA:0000133 is_a: UBERON:0016879 ! future central nervous system relationship: RO:0002202 UBERON:0007135 ! neural keel [Term] id: UBERON:0005076 name: hindbrain-spinal cord boundary +def: "An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord." [OBOL:automatic] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction @@ -39237,6 +59243,10 @@ relationship: RO:0002220 UBERON:0002240 ! adjacent to spinal cord [Term] id: UBERON:0005082 name: tube lumen +def: "A hole in a tube[GO]." [GO:0060609] +xref: AEO:0000078 +xref: EHDAA2:0004618 +xref: RETIRED_EHDAA2:0003078 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002219 UBERON:0000025 ! tube @@ -39245,6 +59255,8 @@ relationship: RO:0002219 UBERON:0000025 ! tube [Term] id: UBERON:0005085 name: ectodermal placode +def: "An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]." [GO:0060788] +xref: AEO:0000218 is_a: UBERON:0001048 ! primordium is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm @@ -39252,6 +59264,8 @@ relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm [Term] id: UBERON:0005090 name: muscle structure +def: "Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]." [GO:0061061] +xref: FMA:30316 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000051 CL:0000187 ! has part muscle cell relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa @@ -39259,17 +59273,25 @@ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0005092 name: right horn of sinus venosus +xref: EHDAA2:0001841 +xref: EHDAA:484 +xref: EMAPA:16239 +xref: FMA:70318 +xref: VHOG:0000489 is_a: UBERON:0002050 ! embryonic structure relationship: BSPO:0000121 UBERON:0002063 ! sinus venosus [Term] id: UBERON:0005153 name: epithelial bud +def: "A bud is a protrusion that forms from an epithelial sheet by localized folding." [GO:0060572] +xref: BTO:0001639 is_a: UBERON:0005157 ! epithelial fold [Term] id: UBERON:0005156 name: reproductive structure +def: "Any anatomical structure that is part of the reproductive system." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0010000 ! multicellular anatomical structure intersection_of: UBERON:0010000 ! multicellular anatomical structure intersection_of: BFO:0000050 UBERON:0000990 ! part of reproductive system @@ -39278,11 +59300,13 @@ relationship: BFO:0000050 UBERON:0000990 ! part of reproductive system [Term] id: UBERON:0005157 name: epithelial fold +def: "An epithelial sheet bent on a linear axis." [GO:0060571] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0005158 name: parenchyma of central nervous system +def: "The functional tissue of the central nervous system consisting of neurons and glial cells." [CL:tm, https://github.com/obophenotype/uberon/issues/8] is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000353 ! parenchyma @@ -39292,18 +59316,44 @@ relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system [Term] id: UBERON:0005162 name: multi cell part structure +def: "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part." [CARO:0001000] +xref: AAO:0011000 +xref: CARO:0001000 +xref: FMA:83115 is_a: UBERON:0000061 ! anatomical structure relationship: RO:0002473 GO:0005575 ! cellular_component [Term] id: UBERON:0005169 name: interstitial tissue +def: "Connective tissue between the cellular elements of a structure." [http://medical-dictionary.thefreedictionary.com/tissue] +xref: FMA:86301 +xref: SCTID:85293002 is_a: UBERON:0003891 ! stroma -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0005171 +name: hepatic duct +def: "Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion)." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0000741 +xref: EHDAA:3049 +xref: EMAPA:16843 +xref: FMA:71891 +xref: galen:HepaticDuct +xref: MA:0000357 +xref: NCIT:C32730 +xref: SCTID:245399002 +xref: VHOG:0000219 +is_a: UBERON:0002394 ! bile duct +relationship: RO:0002176 UBERON:0001174 ! common bile duct +relationship: RO:0002176 UBERON:0002107 ! liver [Term] id: UBERON:0005172 name: abdomen element +def: "An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000522 +xref: SCTID:272631008 is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -39312,6 +59362,8 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0005173 name: abdominal segment element +def: "An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000529 is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -39320,6 +59372,8 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0005174 name: dorsal region element +def: "An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0001901 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum @@ -39328,6 +59382,8 @@ relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0005177 name: trunk region element +def: "An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000516 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -39336,6 +59392,8 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0005178 name: thoracic cavity element +def: "An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000557 is_a: UBERON:0002075 ! viscus is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0000062 ! organ @@ -39345,6 +59403,8 @@ relationship: RO:0001025 UBERON:0002224 ! thoracic cavity [Term] id: UBERON:0005181 name: thoracic segment organ +def: "An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000563 is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -39353,14 +59413,77 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0005194 name: thoracic vein +def: "A vein that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002235 +xref: NCIT:C53142 +xref: SCTID:281472008 is_a: UBERON:0001638 ! vein is_a: UBERON:0003834 ! thoracic segment blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk +[Term] +id: UBERON:0005203 +name: trachea gland +def: "A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen." [http://medical-dictionary.thefreedictionary.com/tracheal+glands, https://github.com/obophenotype/uberon/issues/1197, ISBN:1451113412, MGI:Anna, PMID:15973734] +xref: EMAPA:36574 +xref: FMA:7473 +xref: MA:0002937 +xref: SCTID:197423006 +is_a: UBERON:8410077 ! airway submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea +intersection_of: BFO:0000051 CL:0000159 ! has part seromucus secreting cell +relationship: BFO:0000050 UBERON:0003126 ! part of trachea + +[Term] +id: UBERON:0005221 +name: liver right lobe parenchyma +def: "A parenchyma that is part of a right lobe of liver [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001010 +xref: EMAPA:18317 +xref: FMA:71657 +xref: VHOG:0000840 +is_a: UBERON:0001280 ! liver parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: BFO:0000050 UBERON:0001114 ! part of right lobe of liver + +[Term] +id: UBERON:0005222 +name: liver left lobe parenchyma +def: "A parenchyma that is part of a left lobe of liver [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001002 +xref: EMAPA:18310 +xref: FMA:71658 +xref: VHOG:0000839 +is_a: UBERON:0001280 ! liver parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: BFO:0000050 UBERON:0001115 ! part of left lobe of liver + +[Term] +id: UBERON:0005233 +name: medial-nasal process ectoderm +def: "An ectoderm that is part of a medial nasal prominence [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001078 +xref: EMAPA:16809 +xref: FMA:312675 +xref: VHOG:0000803 +is_a: UBERON:0000924 ! ectoderm +is_a: UBERON:0014702 ! frontonasal process epithelium +intersection_of: UBERON:0000924 ! ectoderm +intersection_of: BFO:0000050 UBERON:0004068 ! part of medial nasal prominence +relationship: BFO:0000050 UBERON:0004068 ! part of medial nasal prominence + [Term] id: UBERON:0005234 name: optic eminence ectoderm +def: "An ectoderm that is part of a optic eminence [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA:940 +xref: EMAPA:16539 +xref: RETIRED_EHDAA2:0001309 +xref: VHOG:0001105 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0004348 ! part of optic eminence @@ -39369,11 +59492,19 @@ relationship: BFO:0000050 UBERON:0004348 ! part of optic eminence [Term] id: UBERON:0005239 name: basal plate metencephalon +xref: EHDAA2:0001154 +xref: EMAPA:17078 +xref: VHOG:0000320 is_a: UBERON:0004064 ! neural tube basal plate [Term] id: UBERON:0005243 name: interventricular septum endocardium +def: "An endocardium that is part of a interventricular septum [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000886 +xref: EHDAA2:0000887 +xref: FMA:83584 +xref: VHOG:0000615 is_a: UBERON:0002165 ! endocardium intersection_of: UBERON:0002165 ! endocardium intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum @@ -39382,6 +59513,9 @@ relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum [Term] id: UBERON:0005248 name: bulbus cordis myocardium +def: "A myocardium that is part of a bulbus cordis [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36488 +xref: VHOG:0000609 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0004706 ! part of bulbus cordis @@ -39390,6 +59524,8 @@ relationship: BFO:0000050 UBERON:0004706 ! part of bulbus cordis [Term] id: UBERON:0005250 name: stomatodeum gland +def: "A gland that is part of a stomodeum." [OBOL:automatic] +xref: VHOG:0000658 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000930 ! part of stomodeum @@ -39398,6 +59534,10 @@ relationship: BFO:0000050 UBERON:0000930 ! part of stomodeum [Term] id: UBERON:0005251 name: yolk sac cavity +def: "An anatomical cavity that is part of a yolk sac [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:16055 +xref: FMA:63942 +xref: VHOG:0000843 is_a: UBERON:0002553 ! anatomical cavity is_a: UBERON:0007473 ! lumen of epithelial sac is_a: UBERON:0012466 ! extraembryonic cavity @@ -39408,6 +59548,16 @@ relationship: RO:0002572 UBERON:0001040 ! yolk sac [Term] id: UBERON:0005253 name: head mesenchyme +def: "Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells." [ISBN:0683400088, MP:0011260] +xref: EFO:0003492 +xref: EHDAA2:0000732 +xref: EHDAA:179 +xref: EMAPA:16098 +xref: EMAPA_RETIRED:16269 +xref: FMA:76622 +xref: TAO:0000113 +xref: VHOG:0000332 +xref: ZFA:0000113 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme @@ -39418,6 +59568,14 @@ relationship: BFO:0000050 UBERON:0009142 ! part of entire embryonic mesenchyme [Term] id: UBERON:0005256 name: trunk mesenchyme +def: "Mesenchyme that is part of a developing trunk." [OBOL:automatic] +xref: EFO:0003485 +xref: EHDAA2:0002092 +xref: EHDAA:377 +xref: EMAPA:16177 +xref: TAO:0000081 +xref: VHOG:0000281 +xref: ZFA:0000081 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme @@ -39429,12 +59587,26 @@ relationship: BFO:0000050 UBERON:0009142 ! part of entire embryonic mesenchyme [Term] id: UBERON:0005290 name: myelencephalon +def: "The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]." [BTO:0000758, Wikipedia:Myelencephalon] +xref: BTO:0000758 +xref: CALOHA:TS-0607 +xref: CALOHA:TS-2365 +xref: DHBA:10662 +xref: EHDAA2:0001207 +xref: EHDAA:5526 +xref: EMAPA:17082 +xref: HBA:9512 +xref: MA:0000205 +xref: VHOG:0000456 +xref: Wikipedia:Myelencephalon is_a: UBERON:0004733 ! segmental subdivision of hindbrain relationship: RO:0002495 UBERON:0010096 ! future myelencephalon [Term] id: UBERON:0005291 name: embryonic tissue +def: "A portion of tissue that is part of an embryo." [OBOL:automatic] +xref: CALOHA:TS-2100 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -39443,6 +59615,12 @@ relationship: BFO:0000050 UBERON:0002050 ! part of embryonic structure [Term] id: UBERON:0005292 name: extraembryonic tissue +def: "Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0003360 +xref: CALOHA:TS-2119 +xref: EFO:0001406 +xref: MAT:0000061 +xref: MIAA:0000061 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component @@ -39451,6 +59629,8 @@ relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic compone [Term] id: UBERON:0005316 name: endocardial endothelium +def: "The endothelial lining of the endocardium." [UBERON:cjm] +xref: FMA:83596 is_a: UBERON:0008307 ! heart endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0002165 ! part of endocardium @@ -39459,6 +59639,8 @@ relationship: BFO:0000050 UBERON:0002165 ! part of endocardium [Term] id: UBERON:0005317 name: pulmonary artery endothelium +def: "An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]." [GO:0061155] +xref: BTO:0000137 is_a: UBERON:0001917 ! endothelium of artery intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery @@ -39467,6 +59649,8 @@ relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery [Term] id: UBERON:0005334 name: oral lamina propria +def: "A lamina propria that is part of a mucosa of oral region." [OBOL:automatic] +xref: EMAPA:26947 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0003343 ! part of mucosa of oral region @@ -39475,6 +59659,10 @@ relationship: BFO:0000050 UBERON:0003343 ! part of mucosa of oral region [Term] id: UBERON:0005337 name: outflow tract of ventricle +def: "A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]." [Wikipedia:Ventricular_outflow_tract] +xref: FMA:13225 +xref: Wikipedia:Ventricular_outflow_tract +xref: XAO:0004140 is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -39483,6 +59671,11 @@ relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle [Term] id: UBERON:0005338 name: outflow tract aortic component +def: "An outflow tract that is part of a aorta." [OBOL:automatic] +xref: EHDAA2:0001353 +xref: EMAPA:17329 +xref: MA:0000101 +xref: VHOG:0001394 is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta @@ -39491,11 +59684,17 @@ relationship: BFO:0000050 UBERON:0000947 ! part of aorta [Term] id: UBERON:0005339 name: outflow tract pulmonary component +xref: EHDAA2:0001359 +xref: EHDAA:4401 +xref: EMAPA:17330 +xref: MA:0000102 +xref: VHOG:0001395 is_a: UBERON:0004145 ! outflow tract [Term] id: UBERON:0005388 name: photoreceptor array +def: "An array of photoreceptors and any supporting cells found in an eye." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0000970 ! part of eye @@ -39507,6 +59706,7 @@ relationship: RO:0002473 CL:0000210 ! photoreceptor cell [Term] id: UBERON:0005389 name: transparent eye structure +def: "A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0000970 ! part of eye relationship: RO:0000086 PATO:0000964 @@ -39514,11 +59714,35 @@ relationship: RO:0000086 PATO:0000964 [Term] id: UBERON:0005396 name: carotid artery segment +def: "One of: the common carotid artery, or its branches, the external and internal carotid arteries." [https://sourceforge.net/tracker/?func=detail&aid=3486870&group_id=76834&atid=994764, Wikipedia:Carotid_artery] +xref: AAO:0010217 +xref: BTO:0000168 +xref: CALOHA:TS-0116 +xref: EFO:0000818 +xref: EHDAA:6385 +xref: EMAPA:18609 +xref: EV:0100379 +xref: FMA:70504 +xref: GAID:478 +xref: galen:CarotidArtery +xref: MA:0001925 +xref: MAT:0000501 +xref: MESH:D002339 +xref: NCIT:C12687 +xref: SCTID:362040006 +xref: SCTID:69105007 +xref: TAO:0000097 +xref: VHOG:0000266 +xref: Wikipedia:Carotid_artery +xref: ZFA:0000097 is_a: UBERON:0004573 ! systemic artery [Term] id: UBERON:0005398 name: female reproductive gland +def: "A sex gland that is part of a female reproductive system." [OBOL:automatic] +xref: BTO:0000254 +xref: MA:0000383 is_a: UBERON:0003937 ! reproductive gland intersection_of: UBERON:0003937 ! reproductive gland intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system @@ -39527,6 +59751,20 @@ relationship: BFO:0000050 UBERON:0003134 ! part of female reproductive organ [Term] id: UBERON:0005409 name: alimentary part of gastrointestinal system +def: "The part of the digestive system that excludes the hepatobiliary system." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000058 +xref: CALOHA:TS-0407 +xref: EHDAA2:0000110 +xref: EHDAA:514 +xref: EMAPA:16246 +xref: FMA:71132 +xref: GAID:294 +xref: galen:GastrointestinalTract +xref: MA:0000323 +xref: MESH:D041981 +xref: NCIT:C12378 +xref: SCTID:373871007 +xref: VHOG:0000412 is_a: UBERON:0000467 ! anatomical system relationship: BFO:0000050 UBERON:0001007 ! part of digestive system relationship: RO:0002492 UBERON:0000066 ! fully formed stage @@ -39534,6 +59772,13 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0005419 name: pectoral appendage bud +def: "A limb bud that develops into a forelimb or pectoral fin." [OBOL:automatic] +comment: at this time we have no need to name a more specific 'pectoral fin bud' class, but we may in future +xref: EFO:0003430 +xref: TAO:0000141 +xref: VHOG:0001754 +xref: VHOG_RETIRED:0001259 +xref: ZFA:0000141 is_a: UBERON:0004357 ! paired limb/fin bud intersection_of: UBERON:0004357 ! paired limb/fin bud intersection_of: RO:0002387 UBERON:0004710 ! pectoral appendage @@ -39544,6 +59789,14 @@ relationship: RO:0002387 UBERON:0004710 ! pectoral appendage [Term] id: UBERON:0005421 name: pectoral appendage apical ectodermal ridge +def: "An apical ectodermal ridge that is part of a pectoral appendage bud." [OBOL:automatic] +xref: EFO:0003487 +xref: EHDAA2:0000138 +xref: EMAPA:16778 +xref: TAO:0000085 +xref: TAO:0000736 +xref: VHOG:0001064 +xref: ZFA:0000085 is_a: UBERON:0004356 ! apical ectodermal ridge intersection_of: UBERON:0004356 ! apical ectodermal ridge intersection_of: BFO:0000050 UBERON:0005419 ! part of pectoral appendage bud @@ -39553,15 +59806,23 @@ relationship: RO:0002202 UBERON:0003372 ! pectoral appendage bud ectoderm [Term] id: UBERON:0005423 name: developing anatomical structure +xref: AEO:0000125 +xref: CALOHA:TS-2122 +xref: EHDAA2:0003125 +xref: FMA:292313 +xref: MIAA:0000019 is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002215 GO:0032502 ! capable of developmental process -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0005425 name: presumptive neural retina +def: "Portion of tissue that is the inner layer of the optic cup and will become the neural retina." [ZFIN:curator] +xref: EHDAA2:0001304 +xref: EMAPA:16675 +xref: TAO:0001071 +xref: VHOG:0000490 +xref: ZFA:0001071 is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0010312 ! immature eye intersection_of: UBERON:0006598 ! presumptive structure @@ -39572,6 +59833,14 @@ relationship: RO:0002387 UBERON:0003902 ! retinal neural layer [Term] id: UBERON:0005426 name: lens vesicle +def: "Portion of tissue that gives rise to the lens." [https://sourceforge.net/tracker/?func=detail&atid=994726&aid=3514998&group_id=76834, ZFIN:curator] +xref: EHDAA2:0000983 +xref: EHDAA:4737 +xref: EMAPA:17163 +xref: SCTID:361510002 +xref: TAO:0002205 +xref: VHOG:0001163 +xref: ZFA:0001679 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: RO:0002202 UBERON:0003073 ! lens placode @@ -39579,6 +59848,9 @@ relationship: RO:0002202 UBERON:0003073 ! lens placode [Term] id: UBERON:0005427 name: corneal primordium +def: "Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea." [ZFIN:ZDB-PUB-061010-3] +xref: TAO:0002188 +xref: ZFA:0001688 is_a: UBERON:0000479 ! tissue is_a: UBERON:0001048 ! primordium is_a: UBERON:0010312 ! immature eye @@ -39588,6 +59860,13 @@ relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye [Term] id: UBERON:0005428 name: vagal neural crest +def: "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]." [ZFIN:curator] +xref: EHDAA2:0002156 +xref: EHDAA:669 +xref: TAO:0000818 +xref: VHOG:0001208 +xref: XAO:0004191 +xref: ZFA:0000818 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0002342 ! part of neural crest @@ -39595,6 +59874,13 @@ relationship: BFO:0000050 UBERON:0002342 ! part of neural crest [Term] id: UBERON:0005432 name: aortic sac +def: "The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates." [MP:0012510] +xref: EHDAA2:0004145 +xref: EHDAA:9826 +xref: EMAPA:36461 +xref: FMA:71008 +xref: RETIRED_EHDAA2:0000133 +xref: SCTID:361527005 is_a: UBERON:0001637 ! artery is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003498 ! heart blood vessel @@ -39604,13 +59890,55 @@ relationship: RO:0002202 UBERON:0004363 ! pharyngeal arch artery [Term] id: UBERON:0005434 name: cervical region +xref: FMA:24219 +xref: SCTID:123958008 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: BFO:0000050 UBERON:0000974 ! part of neck relationship: RO:0002160 NCBITaxon:8287 ! Sarcopterygii +[Term] +id: UBERON:0005436 +name: common hepatic artery +def: "In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:." [Wikipedia:Common_hepatic_artery] +xref: EHDAA2:0000308 +xref: EHDAA:8570 +xref: FMA:14771 +xref: galen:CommonHepaticArtery +xref: MA:0003094 +xref: SCTID:244263001 +xref: Wikipedia:Common_hepatic_artery +is_a: UBERON:0004573 ! systemic artery +relationship: RO:0002252 UBERON:0001640 ! celiac artery + +[Term] +id: UBERON:0005446 +name: foramen rotundum +def: "The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa." [Wikipedia:Foramen_rotundum] +xref: AAO:0000194 +xref: EHDAA2:0000552 +xref: EHDAA:10629 +xref: EMAPA:18712 +xref: FMA:53154 +xref: SCTID:369439002 +xref: VHOG:0001543 +xref: Wikipedia:Foramen_rotundum +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0013685 ! foramen of skull +intersection_of: UBERON:0013685 ! foramen of skull +intersection_of: BFO:0000050 UBERON:0001677 ! part of sphenoid bone +intersection_of: RO:0002570 UBERON:0000377 ! maxillary nerve +relationship: BFO:0000050 UBERON:0001677 ! part of sphenoid bone +relationship: RO:0002570 UBERON:0000377 ! maxillary nerve + [Term] id: UBERON:0005460 name: left vitelline vein +def: "A vitelline vein that is in the left side of a multicellular organism." [OBOL:automatic] +xref: EHDAA2:0000971 +xref: EMAPA:16380 +xref: EMAPA:16698 +xref: FMA:70307 +xref: SCTID:361446008 is_a: UBERON:0005487 ! vitelline vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0005487 ! vitelline vein @@ -39620,6 +59948,12 @@ relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0005472 name: right vitelline vein +def: "A vitelline vein that is in the right side of a multicellular organism." [OBOL:automatic] +xref: EHDAA2:0001766 +xref: EMAPA:16381 +xref: EMAPA:16699 +xref: FMA:70306 +xref: SCTID:361445007 is_a: UBERON:0005487 ! vitelline vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0005487 ! vitelline vein @@ -39629,12 +59963,27 @@ relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0005478 name: sulcus limitans of neural tube +def: "A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]." [http://medical-dictionary.thefreedictionary.com/Sulcus+limitans, http://www.ncbi.nlm.nih.gov/books/NBK10047] +xref: BAMS:slim +xref: BAMS:slm +xref: neuronames:629 is_a: UBERON:0006846 ! surface groove relationship: BFO:0000050 UBERON:0005496 ! part of neural tube lateral wall [Term] id: UBERON:0005487 name: vitelline vein +def: "The paired veins that carry blood from the yolk sac back to the embryo." [MGI:csmith, MP:0010666] +xref: EMAPA:36021 +xref: FMA:70305 +xref: NCIT:C34329 +xref: RETIRED_EHDAA2:0002209 +xref: SCTID:2730004 +xref: SCTID:308832003 +xref: VHOG:0000401 +xref: Wikipedia:Vitelline_veins +xref: XAO:0000376 +xref: XAO:0004147 is_a: UBERON:0004365 ! vitelline blood vessel is_a: UBERON:0013140 ! systemic vein intersection_of: UBERON:0001638 ! vein @@ -39644,18 +59993,45 @@ relationship: RO:0002179 UBERON:0001040 ! yolk sac [Term] id: UBERON:0005496 name: neural tube lateral wall +def: "Portion of tissue on the side of the lumen of the neural tube." [ZFA:0001435] +xref: EHDAA2:0001257 +xref: EHDAA:2873 +xref: EHDAA:912 +xref: EMAPA:16166 +xref: TAO:0001435 +xref: VHOG:0000513 +xref: ZFA:0001435 is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001049 ! part of neural tube [Term] id: UBERON:0005497 name: non-neural ectoderm +comment: Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998). +xref: EFO:0003643 +xref: EHDAA:257 +xref: EMAPA:16074 +xref: RETIRED_EHDAA2:0001273 +xref: TAO:0001178 +xref: VHOG:0001372 +xref: XAO:0004091 +xref: ZFA:0001178 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0005498 name: primitive heart tube +def: "Multi-tissue structure that arises from the heart rudiment and will become the heart tube." [ZFA:0000149] +xref: EHDAA2:0001512 +xref: EHDAA:424 +xref: EHDAA:436 +xref: EMAPA:16215 +xref: FMA:321916 +xref: SCTID:361522004 +xref: TAO:0000149 +xref: Wikipedia:Primitive_heart_tube +xref: ZFA:0000149 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000922 ! part of embryo @@ -39664,6 +60040,9 @@ relationship: RO:0002202 UBERON:0004291 ! heart rudiment [Term] id: UBERON:0005501 name: rhombomere lateral wall +def: "A neural tube lateral wall that is part of a rhombomere." [OBOL:automatic] +xref: EMAPA:32819 +xref: EMAPA:35364 is_a: UBERON:0005496 ! neural tube lateral wall intersection_of: UBERON:0005496 ! neural tube lateral wall intersection_of: BFO:0000050 UBERON:0001892 ! part of rhombomere @@ -39672,6 +60051,14 @@ relationship: BFO:0000050 UBERON:0001892 ! part of rhombomere [Term] id: UBERON:0005563 name: trigeminal neural crest +def: "Cranial neural crest which gives rise to the trigeminal ganglion." [ZFA:0000080] +xref: EFO:0003484 +xref: EHDAA2:0002083 +xref: EHDAA:667 +xref: EMAPA:16170 +xref: TAO:0000080 +xref: VHOG:0000269 +xref: ZFA:0000080 is_a: UBERON:0003099 ! cranial neural crest is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0007530 ! migrating mesenchyme population @@ -39680,6 +60067,14 @@ relationship: BFO:0000050 UBERON:0007213 ! part of mesenchyme derived from head [Term] id: UBERON:0005564 name: gonad primordium +def: "Portion of tissue that gives rise to the immature gonad." [ZFA:0001262] +xref: EFO:0003651 +xref: EHDAA:5927 +xref: EMAPA:17204 +xref: RETIRED_EHDAA2:0002148 +xref: TAO:0001262 +xref: WBbt:0008366 +xref: ZFA:0001262 is_a: UBERON:0001048 ! primordium relationship: BFO:0000050 UBERON:0000990 ! part of reproductive system relationship: RO:0002387 UBERON:0000991 ! gonad @@ -39687,6 +60082,10 @@ relationship: RO:0002387 UBERON:0000991 ! gonad [Term] id: UBERON:0005594 name: head somite +def: "Somite located in the head region, caudal to the otic vesicle." [PMID:11830559] +xref: EHDAA2:0003437 +xref: EMAPA:16172 +xref: XAO:0000313 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0002329 ! somite is_a: UBERON:0005291 ! embryonic tissue @@ -39698,6 +60097,11 @@ relationship: RO:0002202 UBERON:0009617 ! head paraxial mesoderm [Term] id: UBERON:0005597 name: lung primordium +def: "A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum." [XAO:0001002] +xref: AAO:0011059 +xref: EFO:0002578 +xref: EMAPA:36007 +xref: XAO:0001002 is_a: UBERON:0001048 ! primordium relationship: BFO:0000050 UBERON:0008947 ! part of respiratory primordium relationship: RO:0002202 UBERON:0001041 ! foregut @@ -39706,14 +60110,50 @@ relationship: RO:0002387 UBERON:0000170 ! pair of lungs [Term] id: UBERON:0005598 name: trunk somite +def: "A somite that is part of a trunk." [OBOL:automatic] +xref: AAO:0010385 +xref: EHDAA2:0003438 +xref: EMAPA:16184 +xref: XAO:0000314 is_a: UBERON:0002329 ! somite intersection_of: UBERON:0002329 ! somite intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk +[Term] +id: UBERON:0005602 +name: dorsal mesogastrium +def: "The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum." [Wikipedia:Dorsal_mesentery] +xref: EHDAA2:0000416 +xref: EHDAA:3001 +xref: EMAPA:17025 +xref: MA:0001618 +xref: NCIT:C34142 +xref: VHOG:0000352 +xref: Wikipedia:Dorsal_mesentery +is_a: UBERON:0003281 ! mesentery of stomach +relationship: BFO:0000050 UBERON:0002296 ! part of dorsal mesentery +relationship: BFO:0000050 UBERON:0003281 ! part of mesentery of stomach + +[Term] +id: UBERON:0005604 +name: extrahepatic part of hepatic duct +xref: EMAPA:16844 +xref: MA:0001636 +xref: VHOG:0000215 +is_a: UBERON:0002394 ! bile duct +relationship: BFO:0000050 UBERON:0003703 ! part of extrahepatic bile duct +relationship: BFO:0000050 UBERON:0005171 ! part of hepatic duct + [Term] id: UBERON:0005613 name: left dorsal aorta +xref: EHDAA2:0000936 +xref: EHDAA:404 +xref: EMAPA:16205 +xref: MA:0000478 +xref: SCTID:361403005 +xref: VHOG:0000484 is_a: UBERON:0000947 ! aorta is_a: UBERON:0003513 ! trunk blood vessel relationship: BFO:0000050 UBERON:0005805 ! part of dorsal aorta @@ -39721,6 +60161,17 @@ relationship: BFO:0000050 UBERON:0005805 ! part of dorsal aorta [Term] id: UBERON:0005614 name: lens anterior epithelium +def: "A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0000984 +xref: EHDAA:9059 +xref: EMAPA:17304 +xref: EMAPA:17839 +xref: FMA:70612 +xref: MA:0001302 +xref: NCIT:C33641 +xref: RETIRED_EHDAA2:0000976 +xref: SCTID:362521008 +xref: VHOG:0001425 is_a: UBERON:0001803 ! epithelium of lens intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye @@ -39728,9 +60179,53 @@ intersection_of: RO:0002220 UBERON:0001804 ! adjacent to capsule of lens relationship: RO:0002220 UBERON:0000389 ! adjacent to lens cortex relationship: RO:0002220 UBERON:0001804 ! adjacent to capsule of lens +[Term] +id: UBERON:0005616 +name: mesenteric artery +def: "Arteries which arise from the abdominal aorta and distribute to most of the intestines." [MESH:A07.231.114.565, Wikipedia:Mesenteric_artery] +xref: BTO:0000779 +xref: EHDAA2:0001123 +xref: EHDAA:4343 +xref: EMAPA:17312 +xref: MA:0002003 +xref: MESH:D008638 +xref: NCIT:C52975 +xref: SCTID:281084003 +xref: VHOG:0001117 +xref: Wikipedia:Mesenteric_artery +xref: XAO:0000370 +is_a: UBERON:0012254 ! abdominal aorta artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0000160 ! intestine +relationship: RO:0002178 UBERON:0000160 ! intestine + +[Term] +id: UBERON:0005617 +name: mesenteric vein +def: "A vein that returns blood from the intestines." [MESH:A07.231.908.670.385, Wikipedia:Mesenteric_vein] +xref: BTO:0002781 +xref: EHDAA:4442 +xref: EMAPA:17348 +xref: MA:0002177 +xref: MESH:D008642 +xref: NCIT:C53055 +xref: RETIRED_EHDAA2:0001125 +xref: SCTID:304045008 +xref: Wikipedia:Mesenteric_vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: RO:0002179 UBERON:0000160 ! intestine +relationship: RO:0002179 UBERON:0000160 ! intestine + [Term] id: UBERON:0005622 name: right dorsal aorta +xref: EHDAA2:0001720 +xref: EHDAA:406 +xref: EMAPA:16206 +xref: MA:0000479 +xref: SCTID:361404004 +xref: VHOG:0000485 is_a: UBERON:0000947 ! aorta is_a: UBERON:0003513 ! trunk blood vessel relationship: BFO:0000050 UBERON:0005805 ! part of dorsal aorta @@ -39738,12 +60233,30 @@ relationship: BFO:0000050 UBERON:0005805 ! part of dorsal aorta [Term] id: UBERON:0005631 name: extraembryonic membrane +def: "Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo." [ISBN:0073040584] +xref: EHDAA2:0004714 +xref: FMA:305915 +xref: SCTID:362840007 is_a: UBERON:0000158 ! membranous layer relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component +[Term] +id: UBERON:0005637 +name: pyloric region epithelium +def: "An epithelium that is part of a pylorus." [OBOL:automatic] +xref: EHDAA2:0001582 +xref: EMAPA:17633 +xref: RETIRED_EHDAA2:0001927 +is_a: UBERON:0001276 ! epithelium of stomach +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus + [Term] id: UBERON:0005638 name: anterior chamber epithelium +def: "An epithelium that is part of a anterior chamber of eyeball." [OBOL:automatic] +xref: EHDAA2:0000130 is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball @@ -39752,6 +60265,10 @@ relationship: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball [Term] id: UBERON:0005656 name: lens vesicle epithelium +def: "An epithelium that is part of a lens vesicle." [OBOL:automatic] +xref: EHDAA2:0000987 +xref: EMAPA:17165 +xref: VHOG:0000532 is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0005426 ! part of lens vesicle @@ -39760,6 +60277,13 @@ relationship: BFO:0000050 UBERON:0005426 ! part of lens vesicle [Term] id: UBERON:0005662 name: 4th arch ectoderm +def: "An ectoderm that is part of a pharyngeal arch 4." [OBOL:automatic] +xref: EHDAA2:0004032 +xref: EMAPA:16762 +xref: EMAPA:16764 +xref: EMAPA:16768 +xref: RETIRED_EHDAA2:0000094 +xref: VHOG:0001095 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 @@ -39768,6 +60292,13 @@ relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 [Term] id: UBERON:0005666 name: 4th arch endoderm +def: "An endoderm that is part of a pharyngeal arch 4." [OBOL:automatic] +xref: EHDAA2:0004033 +xref: EMAPA:16765 +xref: EMAPA:16767 +xref: EMAPA:16769 +xref: RETIRED_EHDAA2:0000095 +xref: VHOG:0001092 is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 @@ -39776,6 +60307,12 @@ relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 [Term] id: UBERON:0005669 name: peritoneal cavity mesothelium +def: "A mesothelium that is part of a peritoneal cavity." [OBOL:automatic] +xref: BTO:0003156 +xref: EHDAA2:0001447 +xref: EMAPA:16139 +xref: FMA:18147 +xref: SCTID:34073007 is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: RO:0001025 UBERON:0001179 ! peritoneal cavity @@ -39784,6 +60321,8 @@ relationship: RO:0001025 UBERON:0001179 ! peritoneal cavity [Term] id: UBERON:0005672 name: right lung endothelium +def: "An endothelium that is part of a right lung." [OBOL:automatic] +xref: EHDAA2:0001755 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003364 ! epithelium of right lung @@ -39793,15 +60332,35 @@ intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0005673 name: left lung endothelium +def: "An endothelium that is part of a left lung." [OBOL:automatic] +xref: EHDAA2:0000961 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003365 ! epithelium of left lung intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung +[Term] +id: UBERON:0005685 +name: midgut dorsal mesentery +def: "A dorsal mesentery that is part of a midgut." [OBOL:automatic] +xref: EMAPA:16722 +xref: EMAPA:17040 +xref: EMAPA:18671 +xref: RETIRED_EHDAA2:0001187 +xref: SCTID:361434009 +is_a: UBERON:0002296 ! dorsal mesentery +intersection_of: UBERON:0002296 ! dorsal mesentery +intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut +relationship: BFO:0000050 UBERON:0001045 ! part of midgut + [Term] id: UBERON:0005688 name: lens vesicle cavity +def: "An anatomical cavity that is part of a lens vesicle." [OBOL:automatic] +xref: EHDAA2:0000986 +xref: EMAPA:17164 +xref: VHOG:0000531 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0005426 ! lens vesicle @@ -39811,6 +60370,12 @@ relationship: RO:0002572 UBERON:0005426 ! lens vesicle [Term] id: UBERON:0005691 name: 4th arch mesenchyme +def: "Mesenchyme that is part of a pharyngeal arch 4." [OBOL:automatic] +xref: EHDAA2:0000096 +xref: EHDAA:1677 +xref: EMAPA:16770 +xref: FMA:295702 +xref: VHOG:0001052 is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 @@ -39819,15 +60384,48 @@ relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 [Term] id: UBERON:0005702 name: optic eminence mesenchyme +def: "Mesenchyme that is part of a optic eminence." [OBOL:automatic] +xref: EHDAA:942 +xref: EMAPA:16324 +xref: RETIRED_EHDAA2:0001310 +xref: VHOG:0001073 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004348 ! part of optic eminence relationship: BFO:0000050 UBERON:0004348 ! part of optic eminence +[Term] +id: UBERON:0005711 +name: foregut duodenum mesentery +def: "A mesentery of duodenum that is part of a foregut." [OBOL:automatic] +xref: EHDAA2:0000564 +is_a: UBERON:0003397 ! mesentery of duodenum +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0003397 ! mesentery of duodenum +intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut +relationship: BFO:0000050 UBERON:0001041 ! part of foregut +relationship: RO:0002202 UBERON:0011642 ! oral epithelium from ectoderm + +[Term] +id: UBERON:0005712 +name: midgut duodenum mesentery +def: "A mesentery of duodenum that is part of a midgut." [OBOL:automatic] +xref: EHDAA2:0001193 +is_a: UBERON:0003284 ! mesentery of midgut +is_a: UBERON:0003397 ! mesentery of duodenum +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0003397 ! mesentery of duodenum +intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut +relationship: RO:0002202 UBERON:0011642 ! oral epithelium from ectoderm + [Term] id: UBERON:0005720 name: hindbrain venous system +def: "A venous system that is part of a hindbrain." [OBOL:automatic] +xref: EHDAA2:0000776 +xref: EMAPA:18632 +xref: VHOG:0001322 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004582 ! venous system intersection_of: UBERON:0004582 ! venous system @@ -39837,6 +60435,7 @@ relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain [Term] id: UBERON:0005726 name: chemosensory system +xref: BILA:0000139 is_a: UBERON:0001032 ! sensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: RO:0002215 GO:0007606 ! capable of sensory perception of chemical stimulus @@ -39845,6 +60444,11 @@ relationship: RO:0002215 GO:0007606 ! capable of sensory perception of chemical [Term] id: UBERON:0005728 name: extraembryonic mesoderm +xref: EHDAA2:0000474 +xref: EMAPA:31862 +xref: EMAPA:31863 +xref: FMA:296719 +xref: VHOG:0000616 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue @@ -39854,6 +60458,9 @@ relationship: RO:0002202 UBERON:0008780 ! inner cell mass derived epiblast [Term] id: UBERON:0005729 name: pectoral appendage field +def: "A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme." [OBOL:automatic] +xref: TAO:0001453 +xref: ZFA:0001453 is_a: UBERON:0005732 ! paired limb/fin field is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0005732 ! paired limb/fin field @@ -39863,6 +60470,7 @@ relationship: RO:0002387 UBERON:0003413 ! pectoral appendage bud mesenchyme [Term] id: UBERON:0005732 name: paired limb/fin field +def: "A ring of cells capable of forming a limb or paired fin[Gilbert,modified]." [ISBN:9780878932504] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -39875,6 +60483,12 @@ relationship: RO:0002385 UBERON:0004357 ! paired limb/fin bud [Term] id: UBERON:0005734 name: tunica adventitia of blood vessel +def: "The outermost layer of a blood vessel, composed mainly of fibrous tissue." [ISBN:0073040584, Wikipedia:Tunica_externa_(vessels)] +xref: BTO:0002010 +xref: EMAPA:36299 +xref: NCIT:C33818 +xref: SCTID:61066005 +xref: Wikipedia:Tunica_externa_(vessels) is_a: UBERON:0004797 ! blood vessel layer is_a: UBERON:0005742 ! adventitia relationship: RO:0000086 PATO:0002462 @@ -39883,6 +60497,12 @@ relationship: RO:0002473 UBERON:0011824 ! fibrous connective tissue [Term] id: UBERON:0005740 name: tunica intima of artery +def: "A tunica intima that is part of a artery." [OBOL:automatic] +xref: EMAPA:36293 +xref: EV:0100028 +xref: FMA:14272 +xref: galen:IntimaOfArtery +xref: SCTID:40022005 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004797 ! blood vessel layer intersection_of: UBERON:0002523 ! tunica intima @@ -39892,13 +60512,22 @@ relationship: BFO:0000050 UBERON:0000415 ! part of artery wall [Term] id: UBERON:0005742 name: adventitia +def: "An outermost connective tissue covering of an organ, vessel, or other structure[WP]." [Wikipedia:Adventitia] +xref: BTO:0002010 +xref: FMA:45635 +xref: SCTID:30180000 +xref: Wikipedia:Adventitia is_a: UBERON:0004923 ! organ component layer relationship: RO:0002473 UBERON:0002384 ! connective tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005744 name: bone foramen +def: "Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves." [TAO:curator] +xref: AAO:0010438 +xref: TAO:0001736 +xref: VHOG:0001760 +xref: ZFA:0005386 is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element @@ -39907,17 +60536,23 @@ relationship: BFO:0000050 UBERON:0001474 ! part of bone element [Term] id: UBERON:0005764 name: acellular membrane +def: "An acellular anatomical structure that is the bounding layer of a anatomical structure." [OBOL:automatic] +xref: FMA:63871 is_a: UBERON:0000476 ! acellular anatomical structure intersection_of: UBERON:0000476 ! acellular anatomical structure intersection_of: RO:0002007 UBERON:0000061 ! bounding layer of anatomical structure relationship: RO:0002007 UBERON:0000061 ! bounding layer of anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0005769 name: basement membrane of epithelium +def: "An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Basement_membrane] +xref: AAO:0010596 +xref: FMA:63872 +xref: GAID:915 +xref: NCIT:C13191 +xref: SCTID:68989006 +xref: Wikipedia:Basement_membrane is_a: UBERON:0005764 ! acellular membrane relationship: BFO:0000050 UBERON:0000483 ! part of epithelium relationship: BFO:0000051 GO:0005587 ! has part collagen type IV trimer @@ -39928,6 +60563,10 @@ relationship: RO:0002473 GO:0005604 ! basement membrane [Term] id: UBERON:0005800 name: section of aorta +def: "Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle." [ncithesaurus:Aortic_Segment] +xref: FMA:13087 +xref: NCIT:C34027 +xref: SCTID:119203005 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0000947 ! part of aorta @@ -39935,20 +60574,64 @@ relationship: BFO:0000050 UBERON:0000947 ! part of aorta [Term] id: UBERON:0005805 name: dorsal aorta +def: "The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GO:0035907, https://sourceforge.net/p/geneontology/ontology-requests/8525/] +xref: AAO:0011029 +xref: BTO:0004673 +xref: EHDAA:402 +xref: EMAPA:18606 +xref: SCTID:338637006 +xref: TAO:0000014 +xref: VHOG:0000264 +xref: Wikipedia:Dorsal_aorta +xref: XAO:0000051 +xref: ZFA:0000014 is_a: UBERON:0000947 ! aorta is_a: UBERON:0003513 ! trunk blood vessel relationship: BFO:0000050 UBERON:0002201 ! part of vasculature of trunk relationship: RO:0002202 UBERON:0001917 ! endothelium of artery relationship: RO:0002202 UBERON:0003064 ! intermediate mesoderm +[Term] +id: UBERON:0005806 +name: portal system +def: "In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]." [Wikipedia:Portal_venous_system] +xref: FMA:45628 +xref: MESH:D011168 +xref: NCIT:C33344 +xref: SCTID:362063001 +xref: Wikipedia:Portal_venous_system +is_a: UBERON:0002049 ! vasculature + [Term] id: UBERON:0005844 name: spinal cord segment +xref: BIRNLEX:2665 +xref: FMA:62420 +xref: MA:0003080 +xref: SCTID:278748001 is_a: UBERON:0001948 ! regional part of spinal cord +[Term] +id: UBERON:0005845 +name: caudal segment of spinal cord +def: "A spinal cord segment that adjacent_to a caudal region." [OBOL:automatic] +comment: for spinal cord segments, we treat coccygeal/caudal as synonyms - we only differentiate where bone is concerned +xref: FMA:256635 +xref: MA:0003084 +xref: neuronames:1656 +xref: SCTID:278753006 +is_a: UBERON:0005844 ! spinal cord segment +intersection_of: UBERON:0005844 ! spinal cord segment +intersection_of: RO:0002220 UBERON:0006071 ! adjacent to caudal region +relationship: RO:0002220 UBERON:0006071 ! adjacent to caudal region + [Term] id: UBERON:0005856 name: developing mesenchymal condensation +def: "A delimited region of dense mesenchyme within looser mesenchyme." [AEO:0000148] +xref: AEO:0000148 +xref: EHDAA2_RETIRED:0003148 +xref: EHDAA:8979 is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0011585 ! cell condensation relationship: RO:0002473 CL:0000335 ! mesenchyme condensation cell @@ -39956,6 +60639,12 @@ relationship: RO:0002473 CL:0000335 ! mesenchyme condensation cell [Term] id: UBERON:0005863 name: cartilaginous condensation +def: "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." [GO:curator] +xref: AEO:0000147 +xref: EHDAA2_RETIRED:0003147 +xref: EMAPA:32731 +xref: VSAO:0000092 +xref: XAO:0004022 is_a: UBERON:0005856 ! developing mesenchymal condensation relationship: BFO:0000050 UBERON:0004288 ! part of skeleton relationship: RO:0002202 UBERON:0005866 ! pre-cartilage condensation @@ -39963,6 +60652,8 @@ relationship: RO:0002202 UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0005865 name: pre-muscle condensation +xref: AEO:0000149 +xref: EHDAA2_RETIRED:0003149 is_a: UBERON:0005856 ! developing mesenchymal condensation intersection_of: UBERON:0005856 ! developing mesenchymal condensation intersection_of: RO:0002473 CL:0000680 ! muscle precursor cell @@ -39973,6 +60664,10 @@ relationship: RO:0002473 CL:0000680 ! muscle precursor cell [Term] id: UBERON:0005866 name: pre-cartilage condensation +def: "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts." [AEO:0000150, AEO:JB] +xref: AEO:0000150 +xref: EHDAA2:0003150 +xref: EMAPA:32736 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005856 ! developing mesenchymal condensation relationship: BFO:0000050 UBERON:0004288 ! part of skeleton @@ -39981,19 +60676,53 @@ relationship: RO:0002387 UBERON:0007844 ! cartilage element [Term] id: UBERON:0005867 name: mandibular prominence +def: "The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip." [ISBN:0-683-40008-8, MP:0010939] +xref: EHDAA2:0001061 +xref: EHDAA:5871 +xref: EMAPA:17355 +xref: FMA:293051 +xref: NCIT:C34204 +xref: Wikipedia:Mandibular_prominence is_a: UBERON:0012314 ! embryonic facial prominence relationship: BFO:0000050 UBERON:0000166 ! part of oral opening relationship: RO:0002202 UBERON:0007237 ! 1st arch mandibular component +[Term] +id: UBERON:0005868 +name: maxillary prominence +def: "The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw." [ISBN:0-683-40008-8, MP:0010940] +xref: EHDAA2:0001070 +xref: EHDAA:5877 +xref: EMAPA:17359 +xref: FMA:293049 +xref: NCIT:C34206 +xref: SCTID:346355001 +xref: Wikipedia:Maxillary_prominence +is_a: UBERON:0002050 ! embryonic structure +relationship: RO:0002202 UBERON:0007238 ! 1st arch maxillary component + [Term] id: UBERON:0005902 name: occipital region +def: "Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles." [TAO:0001414, UBERONREF:0000007] +xref: AAO:0010199 +xref: BTO:0004675 +xref: FMA:49187 +xref: neuronames:2431 +xref: SCTID:362618001 +xref: TAO:0001414 +xref: XAO:0003173 +xref: ZFA:0001414 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0003128 ! part of cranium [Term] id: UBERON:0005906 name: serous sac +def: "Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]." [FMA:9689, https://github.com/obophenotype/uberon/issues/86] +comment: See notes for serous membrane +xref: FMA:9689 +xref: SCTID:362890006 is_a: UBERON:0000062 ! organ relationship: BFO:0000051 UBERON:0000042 ! has part serous membrane relationship: BFO:0000051 UBERON:0002553 ! has part anatomical cavity @@ -40001,6 +60730,8 @@ relationship: BFO:0000051 UBERON:0002553 ! has part anatomical cavity [Term] id: UBERON:0005911 name: endo-epithelium +def: "Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]." [FMA:69065] +xref: FMA:69065 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000483 ! epithelium @@ -40009,16 +60740,36 @@ intersection_of: RO:0002202 UBERON:0000925 ! endoderm [Term] id: UBERON:0005944 name: axial skeleton plus cranial skeleton +def: "Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]." [FMA:71221, https://github.com/obophenotype/uberon/issues/44, https://github.com/obophenotype/uberon/wiki/The-axial-skeleton, VSAO:0000056, Wikipedia:Axial_skeleton] +xref: AAO:0000963 +xref: EMAPA:17214 +xref: MA:0000308 +xref: NCIT:C32172 +xref: SCTID:361725000 +xref: VSAO:0000056 +xref: Wikipedia:Axial_skeleton +xref: XAO:0004011 is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0011137 ! part of axial skeletal system relationship: RO:0002170 UBERON:0002091 {gci_filler="NCBITaxon:7776", gci_relation="BFO:0000050"} ! appendicular skeleton relationship: RO:0002202 UBERON:0003089 ! sclerotome relationship: RO:0002433 UBERON:0001434 ! skeletal system -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0005945 +name: neurocranial trabecula +xref: EFO:0003677 +xref: TAO:0001321 +xref: ZFA:0001321 +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0003932 ! cartilage element of chondrocranium +relationship: BFO:0000050 UBERON:0003112 ! part of olfactory region [Term] id: UBERON:0005946 name: outflow tract of atrium +def: "An outflow tract that is part of a cardiac atrium." [OBOL:automatic] +xref: FMA:14141 is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium @@ -40028,6 +60779,10 @@ relationship: RO:0002150 UBERON:0002082 ! cardiac ventricle [Term] id: UBERON:0005953 name: outflow part of right ventricle +def: "Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk." [MP:0010428] +xref: FMA:7216 +xref: NCIT:C61368 +xref: SCTID:244379003 is_a: UBERON:0005337 ! outflow tract of ventricle intersection_of: UBERON:0005337 ! outflow tract of ventricle intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle @@ -40038,6 +60793,10 @@ relationship: RO:0002202 UBERON:0009889 ! secondary heart field [Term] id: UBERON:0005956 name: outflow part of left ventricle +def: "Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta." [MP:0010429] +xref: FMA:9473 +xref: SCTID:264070001 +xref: Wikipedia:Aortic_vestibule is_a: UBERON:0005337 ! outflow tract of ventricle intersection_of: UBERON:0005337 ! outflow tract of ventricle intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle @@ -40046,6 +60805,8 @@ relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle [Term] id: UBERON:0005965 name: outflow part of right atrium +def: "Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA]." [FMA:9550, FMA:FMA] +xref: FMA:9550 is_a: UBERON:0005946 ! outflow tract of atrium intersection_of: UBERON:0005946 ! outflow tract of atrium intersection_of: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium @@ -40054,6 +60815,8 @@ relationship: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium [Term] id: UBERON:0005966 name: outflow part of left atrium +def: "An outflow tract of atrium that is part of a left atrium." [OBOL:automatic] +xref: FMA:9551 is_a: UBERON:0005946 ! outflow tract of atrium intersection_of: UBERON:0005946 ! outflow tract of atrium intersection_of: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium @@ -40062,6 +60825,10 @@ relationship: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium [Term] id: UBERON:0005979 name: crista terminalis +def: "The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium." [MP:0010495] +xref: FMA:9236 +xref: SCTID:277693004 +xref: Wikipedia:Crista_terminalis is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium @@ -40070,6 +60837,7 @@ relationship: RO:0002433 UBERON:0002078 ! right cardiac atrium [Term] id: UBERON:0005983 name: heart layer +def: "The laminar structure of the heart." [MP:0010545] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -40080,6 +60848,9 @@ relationship: RO:0002433 UBERON:0000948 ! heart [Term] id: UBERON:0005985 name: coronary vessel +def: "Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation." [MP:0010551] +xref: MESH:D003331 +xref: Wikipedia:Coronary_circulation is_a: UBERON:0000055 ! vessel is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000055 ! vessel @@ -40087,9 +60858,26 @@ intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002433 UBERON:0000948 ! heart +[Term] +id: UBERON:0005988 +name: atrium myocardial trabecula +def: "The supporting bundles of muscular fibers lining the walls of the atrial myocardium." [MP:0010581, ZFA:0005810] +xref: ZFA:0005810 +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0000440 ! trabecula +intersection_of: BFO:0000050 UBERON:0002302 ! part of myocardium of atrium +relationship: BFO:0000050 UBERON:0002302 ! part of myocardium of atrium +relationship: BFO:0000050 UBERON:0004124 ! part of myocardium trabecular layer +relationship: RO:0002433 UBERON:0002302 ! myocardium of atrium + [Term] id: UBERON:0005989 name: atrioventricular septum +def: "The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve." [MP:0010592] +xref: FMA:7136 +xref: SCTID:280151006 +xref: Wikipedia:Atrioventricular_septum is_a: UBERON:0002099 ! cardiac septum is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002099 ! cardiac septum @@ -40102,6 +60890,11 @@ relationship: RO:0002220 UBERON:0002084 ! adjacent to heart left ventricle [Term] id: UBERON:0006002 name: vitelline artery +def: "The paired arteries that carry blood to the yolk sac from the dorsal aorta." [MP:0010664, Wikipedia:Vitelline_arteries] +comment: Development notes:; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult[MP:0010664] +xref: EHDAA2:0002208 +xref: EMAPA:16207 +xref: Wikipedia:Vitelline_arteries is_a: UBERON:0001637 ! artery is_a: UBERON:0004365 ! vitelline blood vessel intersection_of: UBERON:0001637 ! artery @@ -40112,6 +60905,8 @@ relationship: RO:0002252 UBERON:0005805 ! dorsal aorta [Term] id: UBERON:0006003 name: integumentary adnexa +def: "Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers." [http://code.google.com/p/caro2/issues/detail?id=5, http://orcid.org/0000-0002-6601-2165] +xref: Wikipedia:Skin_appendage is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002416 ! part of integumental system @@ -40124,9 +60919,101 @@ intersection_of: BSPO:0000122 UBERON:0000033 ! head relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: BSPO:0000122 UBERON:0000033 ! head +[Term] +id: UBERON:0006068 +name: bone of tail +def: "A bone that is part of a post-anal tail." [OBOL:automatic] +xref: EMAPA:18042 +xref: MA:0000696 +is_a: UBERON:0001474 ! bone element +intersection_of: UBERON:0001474 ! bone element +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + +[Term] +id: UBERON:0006071 +name: caudal region +def: "Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this." [http://orcid.org/0000-0002-6601-2165] +xref: XAO:0000087 +is_a: UBERON:0011676 ! subdivision of organism along main body axis +relationship: BFO:0000050 UBERON:0000154 ! part of posterior region of body +relationship: BSPO:0000099 UBERON:0001245 ! anus +relationship: RO:0002551 UBERON:0006076 ! caudal region of vertebral column + +[Term] +id: UBERON:0006072 +name: cervical region of vertebral column +def: "That portion of the spine comprising the cervical vertebrae. The neck area of the spine." [http://medical-dictionary.thefreedictionary.com/] +xref: AAO:0000092 +xref: BTO:0004148 +xref: EHDAA2:0000238 +xref: EHDAA:5051 +xref: EMAPA:17215 +xref: FMA:24138 +xref: MA:0003154 +xref: NCIT:C69313 +xref: SCTID:260488005 +is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: subdivision_of UBERON:0005434 ! cervical region +relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton +relationship: BFO:0000050 UBERON:0012477 ! part of dorsal part of neck +relationship: subdivision_of UBERON:0005434 ! cervical region + +[Term] +id: UBERON:0006073 +name: thoracic region of vertebral column +def: "That part of the spine comprising the thoracic vertebrae." [http://medical-dictionary.thefreedictionary.com/] +xref: BTO:0004150 +xref: EHDAA:5063 +xref: EMAPA:17396 +xref: FMA:9140 +xref: MA:0003155 +xref: NCIT:C69315 +xref: SCTID:243931006 +is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: subdivision_of UBERON:0000915 ! thoracic segment of trunk +relationship: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of trunk +relationship: BFO:0000050 UBERON:0014477 ! part of thoracic skeleton +relationship: subdivision_of UBERON:0000915 ! thoracic segment of trunk + +[Term] +id: UBERON:0006076 +name: caudal region of vertebral column +def: "Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae." [UBERONREF:0000006] +xref: AAO:0000082 +xref: EMAPA:18043 +xref: MA:0003158 +is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: subdivision_of UBERON:0006071 ! caudal region +relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton +relationship: BFO:0000050 UBERON:0006071 ! part of caudal region +relationship: subdivision_of UBERON:0006071 ! caudal region + +[Term] +id: UBERON:0006077 +name: subdivision of vertebral column +def: "A collection of all skeletal elements in some subdivision of the vertebral column." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:16201 +is_a: UBERON:0000075 ! subdivision of skeletal system +intersection_of: UBERON:0000075 ! subdivision of skeletal system +intersection_of: subdivision_of UBERON:0001130 ! vertebral column +relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column +relationship: BFO:0000050 UBERON:0001137 ! part of dorsum +relationship: subdivision_of UBERON:0001130 ! vertebral column + [Term] id: UBERON:0006207 name: aortico-pulmonary spiral septum +def: "The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions." [MP:0010650, Wikipedia:Aorticopulmonary_septum] +xref: CALOHA:TS-2409 +xref: EHDAA2:0000136 +xref: EHDAA:2592 +xref: EMAPA:16827 +xref: VHOG:0000502 +xref: Wikipedia:Aorticopulmonary_septum is_a: UBERON:0004142 ! outflow tract septum is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002099 ! cardiac septum @@ -40139,6 +61026,14 @@ relationship: RO:0002220 UBERON:0005805 ! adjacent to dorsal aorta [Term] id: UBERON:0006211 name: buccopharyngeal membrane +def: "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx." [MP:0012521] +xref: EHDAA2:0000189 +xref: EHDAA:536 +xref: EMAPA:16259 +xref: FMA:313607 +xref: SCTID:361412007 +xref: VHOG:0000380 +xref: Wikipedia:Buccopharyngeal_membrane is_a: UBERON:0003037 ! septum relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0006264 ! part of mouth-foregut junction @@ -40150,12 +61045,69 @@ relationship: RO:0002254 UBERON:0000925 ! endoderm [Term] id: UBERON:0006218 name: common atrial chamber +xref: EHDAA:1267 +xref: EMAPA:16342 +xref: RETIRED_EHDAA2:0000268 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium +[Term] +id: UBERON:0006227 +name: ethmoid bone primordium +xref: EHDAA2:0000456 +xref: EHDAA:8363 +xref: EMAPA:18023 +xref: FMA:312597 +is_a: UBERON:0001048 ! primordium +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0001679 ! ethmoid bone +relationship: BFO:0000050 UBERON:0002517 ! part of basicranium +relationship: BFO:0000050 UBERON:0011241 ! part of ethmoid region +relationship: RO:0002202 UBERON:0007213 ! mesenchyme derived from head neural crest +relationship: RO:0002387 UBERON:0001679 ! ethmoid bone + +[Term] +id: UBERON:0006235 +name: foregut-midgut junction +def: "An anatomical junctions that overlaps the foregut and midgut." [OBOL:automatic] +xref: EHDAA2:0000569 +xref: EHDAA:526 +xref: EMAPA:16363 +xref: VHOG:0000291 +is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0001041 ! foregut +intersection_of: RO:0002176 UBERON:0001045 ! midgut +relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract +relationship: RO:0002176 UBERON:0001041 ! foregut +relationship: RO:0002176 UBERON:0001045 ! midgut + +[Term] +id: UBERON:0006236 +name: tetrapod frontal bone primordium +xref: EHDAA2:0000577 +xref: EHDAA:9540 +xref: EMAPA:18017 +xref: FMA:312589 +is_a: UBERON:0001048 ! primordium +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0000209 ! tetrapod frontal bone +relationship: RO:0002387 UBERON:0000209 ! tetrapod frontal bone + [Term] id: UBERON:0006238 name: future brain +def: "The embryonic precursor of the brain." [NLX:94995] +xref: BAMS:Enc +xref: BTO:0004726 +xref: EFO:0003431 +xref: EHDAA:300 +xref: EHDAA:830 +xref: EMAPA:16089 +xref: FMA:312967 +xref: RETIRED_EHDAA2:0000591 +xref: TAO:0000146 +xref: ZFA:0000146 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0002346 ! part of neurectoderm relationship: RO:0002387 UBERON:0000955 ! brain @@ -40163,6 +61115,10 @@ relationship: RO:0002387 UBERON:0000955 ! brain [Term] id: UBERON:0006239 name: future central tendon +def: "A tendon that has the potential to develop into a central tendon." [OBOL:automatic] +xref: EHDAA2:0000593 +xref: EHDAA:4118 +xref: EMAPA:25035 is_a: UBERON:0000043 ! tendon is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure @@ -40175,14 +61131,42 @@ relationship: RO:0002387 UBERON:0006670 ! central tendon of diaphragm [Term] id: UBERON:0006241 name: future spinal cord +xref: EFO:0003438 +xref: EHDAA2:0000674 +xref: EHDAA:898 +xref: EMAPA:16092 +xref: EMAPA:16755 +xref: TAO:0000417 +xref: ZFA:0000417 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: RO:0002387 UBERON:0001049 ! neural tube relationship: RO:0002387 UBERON:0002240 ! spinal cord +[Term] +id: UBERON:0006242 +name: gallbladder primordium +def: "A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops." [ISBN:0815318960, XAO:0004205] +xref: EHDAA2:0000700 +xref: EHDAA:3047 +xref: EMAPA:16713 +xref: XAO:0004205 +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0002110 ! gallbladder +relationship: BFO:0000050 UBERON:0004912 ! part of biliary bud +relationship: RO:0002202 UBERON:0001152 ! cystic duct +relationship: RO:0002387 UBERON:0002110 ! gallbladder + [Term] id: UBERON:0006264 name: mouth-foregut junction +def: "An anatomical junctions that overlaps the mouth and foregut." [OBOL:automatic] +xref: EHDAA:534 +xref: EMAPA:16258 +xref: RETIRED_EHDAA2:0001205 +xref: VHOG:0000592 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002131 UBERON:0000165 ! overlaps mouth @@ -40194,6 +61178,12 @@ relationship: RO:0002131 UBERON:0001041 ! overlaps foregut [Term] id: UBERON:0006267 name: notochordal plate +def: "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord." [VHOG:0001212] +xref: EHDAA2:0001278 +xref: EHDAA:264 +xref: EMAPA:16101 +xref: NCIT:C34231 +xref: VHOG:0001212 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue @@ -40203,13 +61193,41 @@ relationship: RO:0002202 UBERON:0006268 ! notochordal process [Term] id: UBERON:0006268 name: notochordal process +def: "A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot." [http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/05embryonicperiod.htm] +comment: The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. +xref: EHDAA2:0001279 +xref: EHDAA:224 +xref: EMAPA:16102 +xref: FMA:293135 +xref: NCIT:C34232 +xref: VHOG:0001213 is_a: UBERON:0005423 ! developing anatomical structure relationship: RO:0002160 NCBITaxon:7711 ! Chordata relationship: RO:0002202 UBERON:0000924 ! ectoderm +[Term] +id: UBERON:0006271 +name: orbital fissure +def: "Either of two openings transmitting nerves and blood vessels to or from the orbit." [http://www.merriam-webster.com/medical/orbital%20fissure] +xref: EHDAA2:0001328 +xref: EHDAA:10648 +xref: EMAPA:18717 +xref: SCTID:280546005 +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0013685 ! foramen of skull +intersection_of: UBERON:0013685 ! foramen of skull +intersection_of: BFO:0000050 UBERON:0001697 ! part of orbit of skull +relationship: BFO:0000050 UBERON:0001697 ! part of orbit of skull + [Term] id: UBERON:0006279 name: pleuroperitoneal canal +def: "Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity." [ISBN:0124020607, VHOG:0001505] +xref: EHDAA2:0001481 +xref: EHDAA:4128 +xref: EMAPA:17707 +xref: SCTID:361413002 +xref: VHOG:0001505 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003914 ! epithelial tube @@ -40223,14 +61241,44 @@ relationship: RO:0002176 UBERON:0002402 ! pleural cavity [Term] id: UBERON:0006283 name: future cardiac ventricle +def: "Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle." [ZFA:0001719] +comment: The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum[WP] +xref: EHDAA2:0001531 +xref: EMAPA:16350 +xref: FMA:71006 +xref: NCIT:C34160 +xref: SCTID:361524003 +xref: TAO:0002231 +xref: Wikipedia:Embryonic_ventricle +xref: ZFA:0001719 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0004141 ! part of heart tube relationship: BFO:0000050 UBERON:0005498 ! part of primitive heart tube relationship: RO:0002387 UBERON:0002082 ! cardiac ventricle +[Term] +id: UBERON:0006293 +name: spleen primordium +def: "A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]." [ISBN:0123747295, MP:0011263] +xref: EHDAA2:0001904 +xref: EHDAA:3003 +xref: EMAPA:18535 +xref: XAO:0000326 +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0002050 ! embryonic structure +is_a: UBERON:0003104 ! mesenchyme +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005291 ! embryonic tissue +relationship: BFO:0000050 UBERON:0005602 ! part of dorsal mesogastrium +relationship: RO:0002202 UBERON:0004872 ! splanchnic layer of lateral plate mesoderm + [Term] id: UBERON:0006304 name: future trigeminal ganglion +comment: See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/13 and https://github.com/obophenotype/uberon/issues/693 -- consider merging into trigeminal ganglion, as this complicates the model +xref: EHDAA:924 +xref: EMAPA:16663 +xref: RETIRED_EHDAA2:0002089 is_a: UBERON:0003869 ! presumptive ganglion relationship: RO:0002202 UBERON:0005563 ! trigeminal neural crest relationship: RO:0002387 UBERON:0001675 ! trigeminal ganglion @@ -40239,6 +61287,12 @@ relationship: RO:0002494 UBERON:0003070 ! trigeminal placode complex [Term] id: UBERON:0006311 name: chamber of eyeball +def: "A segment of the eyeball that is filled with refractive media." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0002085 +xref: FMA:58071 +xref: MA:0002459 +xref: NCIT:C32301 +xref: SCTID:280540004 is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000063 ! organ subunit @@ -40250,12 +61304,21 @@ relationship: RO:0001015 UBERON:0006312 ! ocular refractive media [Term] id: UBERON:0006312 name: ocular refractive media +def: "Body substance in a liquid or semi-solid state in the eyeball which serves to refract light." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0001911 is_a: UBERON:0000463 ! organism substance relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye [Term] id: UBERON:0006314 name: bodily fluid +def: "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not." [MESH:A12.207, Wikipedia:Body_fluid] +xref: BIRNLEX:20 +xref: FMA:280556 +xref: GAID:266 +xref: galen:BodyFluid +xref: MESH:D001826 +xref: Wikipedia:Body_fluid is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0000086 PATO:0001548 @@ -40264,6 +61327,9 @@ relationship: RO:0000086 PATO:0001548 [Term] id: UBERON:0006331 name: brainstem nucleus +def: "A nucleus of brain that is part of a brainstem." [OBOL:automatic] +xref: EMAPA:32790 +xref: MA:0000821 is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0002298 ! part of brainstem @@ -40272,6 +61338,11 @@ relationship: BFO:0000050 UBERON:0002298 ! part of brainstem [Term] id: UBERON:0006347 name: communicating artery +def: "An artery that connects two larger arteries." [ncithesaurus:Communicating_Artery] +comment: Grouping for anterior and posterior +xref: EMAPA:18598 +xref: MA:0001938 +xref: NCIT:C52851 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002176 UBERON:0001637 {cardinality="2"} ! artery @@ -40280,6 +61351,11 @@ relationship: RO:0002176 UBERON:0001637 ! artery [Term] id: UBERON:0006518 name: right lung lobe +def: "A lobe of lung that is part of a right lung." [OBOL:automatic] +xref: EMAPA:35155 +xref: MA:0001791 +xref: NCIT:C48944 +xref: SCTID:272654004 is_a: UBERON:0000101 ! lobe of lung intersection_of: UBERON:0000101 ! lobe of lung intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -40288,6 +61364,11 @@ relationship: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0006524 name: alveolar system +def: "System pertaining to a bronchus and alveoli." [BTO:0000136] +xref: BTO:0000136 +xref: CALOHA:TS-1296 +xref: EMAPA:32692 +xref: MA:0000416 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002048 ! part of lung @@ -40296,6 +61377,8 @@ relationship: RO:0002433 UBERON:0002048 ! lung [Term] id: UBERON:0006525 name: left lung alveolar system +xref: EMAPA:19001 +xref: MA:0001775 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002168 ! part of left lung @@ -40304,6 +61387,8 @@ relationship: BFO:0000050 UBERON:0006524 ! part of alveolar system [Term] id: UBERON:0006526 name: right lung alveolar system +xref: EMAPA:35717 +xref: MA:0001784 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002167 ! part of right lung @@ -40312,6 +61397,8 @@ relationship: BFO:0000050 UBERON:0006524 ! part of alveolar system [Term] id: UBERON:0006535 name: skin secretion +def: "A portion of organism substance that secreted_by a zone of skin." [OBOL:automatic] +xref: MA:0002537 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0000014 ! produced by zone of skin @@ -40320,6 +61407,8 @@ relationship: RO:0003001 UBERON:0000014 ! produced by zone of skin [Term] id: UBERON:0006537 name: female reproductive gland secretion +def: "A portion of organism substance that is secreted by a female reproductive gland." [UBERON:cjm] +xref: MA:0002510 is_a: UBERON:0022293 ! reproductive gland secretion intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0005398 ! produced by female reproductive gland @@ -40328,20 +61417,39 @@ relationship: RO:0003001 UBERON:0005398 ! produced by female reproductive gland [Term] id: UBERON:0006538 name: respiratory system fluid/secretion +def: "A portion of organism substance that secreted_by a respiratory system." [OBOL:automatic] +xref: EMAPA:36550 +xref: MA:0002533 +xref: NCIT:C13722 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0001004 ! produced by respiratory system relationship: RO:0003001 UBERON:0001004 ! produced by respiratory system +[Term] +id: UBERON:0006555 +name: excretory tube +def: "A tube that is part of a excretory system." [OBOL:automatic] +is_a: UBERON:0000025 ! tube +intersection_of: UBERON:0000025 ! tube +intersection_of: BFO:0000050 UBERON:0001008 ! part of renal system +relationship: BFO:0000050 UBERON:0001008 ! part of renal system + [Term] id: UBERON:0006562 name: pharynx +def: "The pharynx is the part of the digestive system immediately posterior to the mouth[GO]." [GO:0060465] +xref: MAT:0000049 +xref: MESH:D010614 +xref: MIAA:0000049 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: RO:0002160 NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0006563 name: tunica media of pulmonary trunk +def: "Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA]." [FMA:85030, FMA:FMA] +xref: FMA:85030 is_a: UBERON:0007239 ! tunica media of artery intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0002333 ! part of pulmonary trunk @@ -40350,26 +61458,77 @@ relationship: BFO:0000050 UBERON:0002333 ! part of pulmonary trunk [Term] id: UBERON:0006566 name: left ventricle myocardium +def: "A myocardium that is part of a left ventricle of a heart." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:9558 +xref: MA:0002983 +xref: SCTID:362021000 is_a: UBERON:0001083 ! myocardium of ventricle intersection_of: UBERON:0001083 ! myocardium of ventricle intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: RO:0002150 UBERON:0003618 ! aorta tunica media -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006567 name: right ventricle myocardium +def: "A myocardium that is part of a right ventricle of a heart." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:9535 +xref: MA:0002984 +xref: SCTID:362020004 is_a: UBERON:0001083 ! myocardium of ventricle intersection_of: UBERON:0001083 ! myocardium of ventricle intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: RO:0002150 UBERON:0006563 ! tunica media of pulmonary trunk -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0006570 +name: trabecula carnea of right ventricle +def: "A trabecula carnea that is part of a heart right ventricle." [OBOL:automatic] +xref: FMA:7270 +xref: SCTID:192373001 +is_a: UBERON:0002511 ! trabecula carnea +intersection_of: UBERON:0002511 ! trabecula carnea +intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle +relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle + +[Term] +id: UBERON:0006571 +name: trabecula carnea of left ventricle +def: "A trabecula carnea that is part of a heart left ventricle." [OBOL:automatic] +xref: FMA:7271 +xref: SCTID:190344008 +is_a: UBERON:0002511 ! trabecula carnea +intersection_of: UBERON:0002511 ! trabecula carnea +intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle +relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle + +[Term] +id: UBERON:0006574 +name: pectinate line +def: "The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:." [Wikipedia:Pectinate_line] +xref: EMAPA:19159 +xref: FMA:75383 +xref: NCIT:C34245 +xref: SCTID:245445008 +xref: Wikipedia:Pectinate_line +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:8410024 ! intestinal junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0000931 ! proctodeum +intersection_of: RO:0002176 UBERON:0001046 ! hindgut +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: RO:0002176 UBERON:0000931 ! proctodeum +relationship: RO:0002176 UBERON:0001046 ! hindgut [Term] id: UBERON:0006595 name: presumptive endoderm +def: "Presumptive structure of the blastula that will develop into endoderm." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000471 +xref: EFO:0003437 +xref: TAO:0000416 +xref: ZFA:0000416 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: BFO:0000050 UBERON:0000307 ! part of blastula @@ -40381,6 +61540,10 @@ relationship: RO:0002387 UBERON:0000925 ! endoderm [Term] id: UBERON:0006596 name: presumptive blood +xref: AAO:0000468 +xref: EFO:0003439 +xref: TAO:0000568 +xref: ZFA:0000568 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0000178 ! blood @@ -40389,6 +61552,10 @@ relationship: RO:0002387 UBERON:0000178 ! blood [Term] id: UBERON:0006598 name: presumptive structure +def: "Portion of embryonic tissue determined by fate mapping to become a structure." [GOC:CVS, GOC:YMB, ZFA:0001116] +xref: AAO:0000479 +xref: TAO:0001116 +xref: ZFA:0001116 is_a: UBERON:0002050 ! embryonic structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -40398,6 +61565,12 @@ relationship: RO:0002387 UBERON:0000061 ! anatomical structure [Term] id: UBERON:0006601 name: presumptive ectoderm +def: "Presumptive structure of the blastula that will develop into ectoderm." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000470 +xref: EFO:0003466 +xref: TAO:0001376 +xref: XAO:0004132 +xref: ZFA:0001376 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: BFO:0000050 UBERON:0000307 ! part of blastula @@ -40409,6 +61582,11 @@ relationship: RO:0002387 UBERON:0000924 ! ectoderm [Term] id: UBERON:0006603 name: presumptive mesoderm +def: "Presumptive structure of the blastula that will develop into mesoderm." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000476 +xref: EFO:0003467 +xref: TAO:0001377 +xref: ZFA:0001377 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: BFO:0000050 UBERON:0000307 ! part of blastula @@ -40417,9 +61595,27 @@ relationship: BFO:0000050 UBERON:0000307 ! part of blastula relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa relationship: RO:0002387 UBERON:0000926 ! mesoderm +[Term] +id: UBERON:0006660 +name: muscular coat +def: "A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis." [Wikipedia:Muscular_layer] +xref: BTO:0004838 +xref: SCTID:86915006 +xref: Wikipedia:Muscular_layer +is_a: UBERON:0018260 ! layer of muscle tissue +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002220 UBERON:0000009 ! adjacent to submucosa + [Term] id: UBERON:0006670 name: central tendon of diaphragm +def: "The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers." [MGI:csmith, MP:0012061] +xref: EMAPA:17702 +xref: FMA:58279 +xref: NCIT:C34119 +xref: SCTID:244943002 +xref: VHOG:0001399 +xref: Wikipedia:Central_tendon_of_diaphragm is_a: UBERON:0000043 ! tendon is_a: UBERON:0003570 ! respiratory system connective tissue is_a: UBERON:0003837 ! thoracic segment connective tissue @@ -40430,14 +61626,39 @@ relationship: RO:0002495 UBERON:0006239 ! future central tendon [Term] id: UBERON:0006677 name: surface of epithelium +def: "An anatomical boundary that adjacent_to a epithelium." [OBOL:automatic] +xref: FMA:70997 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: RO:0002007 UBERON:0000483 ! bounding layer of epithelium relationship: RO:0002007 UBERON:0000483 ! bounding layer of epithelium +[Term] +id: UBERON:0006686 +name: spinal vein +def: "A vein that is part of a vertebral column." [OBOL:automatic] +xref: EMAPA:18255 +xref: FMA:76735 +xref: MA:0002108 +xref: SCTID:181376008 +xref: Wikipedia:Spinal_veins +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: BFO:0000050 UBERON:0001130 ! part of vertebral column +relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column + [Term] id: UBERON:0006761 name: corneo-scleral junction +def: "The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm." [MP:0013477] +comment: This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343 +xref: EFO:0001403 +xref: FMA:58342 +xref: GAID:896 +xref: MESH:D016850 +xref: SCTID:63716004 +xref: Wikipedia:Corneal_limbus +xref: ZFA:0005570 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction @@ -40446,11 +61667,14 @@ intersection_of: RO:0002176 UBERON:0001773 ! sclera relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: RO:0002176 UBERON:0000964 ! cornea relationship: RO:0002176 UBERON:0001773 ! sclera -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006799 name: glandular epithelium +def: "An epithelium that is composed primarily of secretory cells." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0002991 +xref: NCIT:C43370 +xref: NCIT:C45715 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002473 CL:0000150 ! glandular epithelial cell @@ -40459,14 +61683,30 @@ relationship: RO:0002473 CL:0000150 ! glandular epithelial cell [Term] id: UBERON:0006815 name: areolar connective tissue +def: "Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand." [FMA:63897] +xref: AAO:0000027 +xref: FMA:63897 +xref: SCTID:68477002 is_a: UBERON:0011825 ! loose connective tissue relationship: BFO:0000050 UBERON:0000030 ! part of lamina propria relationship: BFO:0000051 CL:1000303 ! has part fibroblast of areolar connective tissue relationship: protects UBERON:0000062 ! organ +[Term] +id: UBERON:0006828 +name: trabecula carnea of atrium +def: "The supporting bundles of muscular fibers lining the walls of the atria[MP]." [MP:0010581] +is_a: UBERON:0002511 ! trabecula carnea +intersection_of: UBERON:0002511 ! trabecula carnea +intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium +relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium + [Term] id: UBERON:0006833 name: lumen of trachea +def: "An anatomical space that surrounded_by a trachea." [OBOL:automatic] +xref: FMA:7469 +xref: SCTID:197486000 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0003126 ! trachea @@ -40476,6 +61716,9 @@ relationship: RO:0002572 UBERON:0003126 ! trachea [Term] id: UBERON:0006834 name: uterus or analog +def: "A subdivision of a the reproductive tract in a female organism that is the site of embryo development." [http://orcid.org/0000-0002-6601-2165] +xref: TADS:0000421 +xref: WBbt:0006760 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube @@ -40484,23 +61727,78 @@ relationship: BFO:0000050 UBERON:0000474 ! part of female reproductive system relationship: RO:0002160 NCBITaxon:33208 ! Metazoa relationship: site_of GO:0009790 ! embryo development +[Term] +id: UBERON:0006841 +name: central vein of liver +def: "Vein that is central to a lobule in the liver." [ZFA:0005168] +xref: FMA:17544 +xref: NCIT:C32281 +xref: SCTID:272023004 +xref: TAO:0005168 +xref: Wikipedia:Central_veins_of_liver +xref: ZFA:0005168 +is_a: UBERON:0013126 ! vein of abdomen +is_a: UBERON:0015796 ! liver blood vessel +relationship: BFO:0000050 UBERON:0004647 ! part of liver lobule + [Term] id: UBERON:0006846 name: surface groove +def: "A furrow or an incomplete tube." [AEO:0000161, AEO:JB, https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/4] +comment: Surface groove is modelled as immaterial - see https://github.com/obophenotype/uberon/issues/2667 for discussion +xref: AEO:0000161 +xref: EHDAA2_RETIRED:0003161 is_a: UBERON:0000466 ! immaterial anatomical entity relationship: RO:0000086 PATO:0002255 +[Term] +id: UBERON:0006866 +name: terminal part of digestive tract +def: "The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus." [http://orcid.org/0000-0002-6601-2165] +xref: WBbt:0005773 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: RO:0002150 UBERON:0001245 ! anus +relationship: RO:0002202 UBERON:0001046 ! hindgut + [Term] id: UBERON:0006876 name: vasculature of organ +def: "A vasculature that is part of a organ." [OBOL:automatic] +xref: FMA:74612 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000062 ! part of organ relationship: BFO:0000050 UBERON:0000062 ! part of organ +[Term] +id: UBERON:0006877 +name: vasculature of liver +def: "A vasculature that is part of a liver." [OBOL:automatic] +xref: EHDAA2:0003454 +xref: EMAPA:35501 +xref: FMA:73748 +is_a: UBERON:0002201 ! vasculature of trunk +is_a: UBERON:0006876 ! vasculature of organ +intersection_of: UBERON:0002049 ! vasculature +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: UBERON:0006904 name: head mesenchyme from mesoderm +def: "A head mesenchyme that develops_from a mesoderm." [OBOL:automatic] +xref: AAO:0011051 +xref: EFO:0003337 +xref: EFO:0003603 +xref: EHDAA2:0001118 +xref: EHDAA:655 +xref: EMAPA:16099 +xref: EMAPA_RETIRED:16270 +xref: FMA:293859 +xref: TAO:0000998 +xref: VHOG:0000185 +xref: XAO:0000053 +xref: ZFA:0000998 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005253 ! head mesenchyme intersection_of: UBERON:0005253 ! head mesenchyme @@ -40510,6 +61808,11 @@ relationship: RO:0002202 UBERON:0003063 ! prechordal plate [Term] id: UBERON:0006905 name: mandibular process mesenchyme +def: "Mesenchyme that is part of a mandibular prominence." [OBOL:automatic] +xref: EHDAA2:0001062 +xref: EHDAA:5861 +xref: EHDAA:5873 +xref: EMAPA:17357 is_a: UBERON:0005253 ! head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005867 ! part of mandibular prominence @@ -40518,6 +61821,10 @@ relationship: BFO:0000050 UBERON:0005867 ! part of mandibular prominence [Term] id: UBERON:0006909 name: lumen of digestive tract +def: "An anatomical space that surrounded_by a digestive tract." [OBOL:automatic] +xref: BTO:0000349 +xref: EMAPA:32908 +xref: FMA:45677 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001555 ! digestive tract @@ -40527,6 +61834,10 @@ relationship: RO:0002572 UBERON:0001555 ! digestive tract [Term] id: UBERON:0006913 name: lip epithelium +def: "An epithelium that is part of a lip." [OBOL:automatic] +xref: BTO:0004468 +xref: TAO:0005334 +xref: ZFA:0005334 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001833 ! part of lip @@ -40535,6 +61846,11 @@ relationship: BFO:0000050 UBERON:0001833 ! part of lip [Term] id: UBERON:0006914 name: squamous epithelium +def: "An epithelium characterised by its most superficial layer consisting of squamous epithelial cells." [Wikipedia:Squamous_epithelium] +xref: BTO:0002072 +xref: NCIT:C12848 +xref: SCTID:40118003 +xref: Wikipedia:Squamous_epithelium is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000051 CL:0000076 ! has part squamous epithelial cell @@ -40543,6 +61859,10 @@ relationship: BFO:0000051 CL:0000076 ! has part squamous epithelial cell [Term] id: UBERON:0006915 name: stratified squamous epithelium +def: "Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]." [FMA:45563, Wikipedia:Stratified_squamous_epithelium] +xref: FMA:45563 +xref: NCIT:C13180 +xref: Wikipedia:Stratified_squamous_epithelium is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0000486 ! multilaminar epithelium @@ -40551,6 +61871,12 @@ intersection_of: BFO:0000051 CL:0000076 ! has part squamous epithelial cell [Term] id: UBERON:0006920 name: esophagus squamous epithelium +def: "A squamous epithelium that is part of a esophagus." [OBOL:automatic] +xref: BTO:0003635 +xref: CALOHA:TS-1250 +xref: EMAPA:35324 +xref: MA:0001567 +xref: NCIT:C49222 is_a: UBERON:0001976 ! epithelium of esophagus is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0006914 ! squamous epithelium @@ -40559,6 +61885,9 @@ intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus [Term] id: UBERON:0006921 name: stomach squamous epithelium +def: "A squamous epithelium that is part of a stomach." [OBOL:automatic] +xref: EMAPA:35824 +xref: MA:0001611 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0001276 ! epithelium of stomach intersection_of: UBERON:0006914 ! squamous epithelium @@ -40567,6 +61896,10 @@ intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: UBERON:0006924 name: stomach glandular epithelium +def: "A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands." [ISBN:0073040584] +xref: EMAPA:35814 +xref: FMA:63458 +xref: MA:0002784 is_a: UBERON:0001276 ! epithelium of stomach is_a: UBERON:0006929 ! glandular columnar epithelium intersection_of: UBERON:0006799 ! glandular epithelium @@ -40577,6 +61910,9 @@ relationship: BFO:0000051 UBERON:0000325 ! has part gastric gland [Term] id: UBERON:0006925 name: digestive system gland +def: "Any gland that is part of the digestive system." [UBERON:cjm] +xref: AAO:0000130 +xref: BTO:0000345 is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0002368 ! endocrine gland @@ -40585,6 +61921,9 @@ intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system [Term] id: UBERON:0006929 name: glandular columnar epithelium +def: "Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]." [FMA:64800] +xref: FMA:64800 +xref: NCIT:C13182 is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0006799 ! glandular epithelium intersection_of: UBERON:0000485 ! simple columnar epithelium @@ -40593,6 +61932,7 @@ intersection_of: RO:0002473 CL:0000150 ! glandular epithelial cell [Term] id: UBERON:0006930 name: glandular cuboidal epithelium +xref: FMA:66809 is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0006799 ! glandular epithelium intersection_of: UBERON:0000484 ! simple cuboidal epithelium @@ -40601,6 +61941,9 @@ intersection_of: RO:0002473 CL:0000150 ! glandular epithelial cell [Term] id: UBERON:0006931 name: stomach glandular region mucosa +def: "Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:27167 +xref: MA:0001614 is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0001199 ! mucosa of stomach intersection_of: BFO:0000050 UBERON:0011953 ! part of stomach glandular region @@ -40609,6 +61952,10 @@ relationship: BFO:0000050 UBERON:0011953 ! part of stomach glandular region [Term] id: UBERON:0006934 name: sensory epithelium +def: "Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue." [BTO:0000314] +xref: CALOHA:TS-0682 +xref: FMA:62410 +xref: SCTID:309045006 is_a: UBERON:0000488 ! atypical epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000051 CL:0000098 ! has part sensory epithelial cell @@ -40618,17 +61965,28 @@ relationship: BFO:0000051 CL:0000098 ! has part sensory epithelial cell [Term] id: UBERON:0006960 name: ovary stroma +def: "The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis." [Wikipedia:Stroma_of_ovary] +xref: CALOHA:TS-1246 +xref: EMAPA:28880 +xref: FMA:18626 +xref: MA:0002991 +xref: NCIT:C33638 +xref: SCTID:259306002 +xref: Wikipedia:Stroma_of_ovary is_a: UBERON:0003891 ! stroma is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000051 CL:0002095 ! has part hilus cell of ovary -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006965 name: vascular cord +def: "The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]." [GO:0072360, ZFA:0005077] +xref: EFO:0003709 +xref: TAO:0005077 +xref: ZFA:0005077 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0014903 ! part of primordial vasculature relationship: BFO:0000051 CL:0000115 ! has part endothelial cell @@ -40638,6 +61996,8 @@ relationship: site_of GO:0048754 ! branching morphogenesis of an epithelial tube [Term] id: UBERON:0006966 name: coronary capillary +def: "A capillary that is part of the coronary system." [http://orcid.org/0000-0002-6601-2165] +xref: ZFA:0005813 is_a: UBERON:0001982 ! capillary is_a: UBERON:0003498 ! heart blood vessel intersection_of: UBERON:0001982 ! capillary @@ -40646,11 +62006,28 @@ intersection_of: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: UBERON:0006984 name: anatomical surface +def: "A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n." [CARO:0001002] +comment: Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism. +xref: BILA:0000010 +xref: CARO:0001002 +xref: EHDAA2_RETIRED:0003192 +xref: FMA:24137 +xref: NCIT:C34022 is_a: UBERON:0010199 ! bona-fide anatomical boundary [Term] id: UBERON:0007005 name: cardiogenic splanchnic mesoderm +def: "The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]." [http://www.drugs.com/dict/cardiogenic-mesoderm.html, https://github.com/obophenotype/insect_neuroanatomy_ontology/issues/7, XAO:0000235] +xref: AAO:0011021 +xref: BILA:0000051 +xref: EFO:0000315 +xref: EHDAA2:0000214 +xref: EHDAA:385 +xref: FMA:293143 +xref: SCTID:360387000 +xref: VHOG:0001641 +xref: XAO:0000235 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0004140 ! part of primary heart field @@ -40661,6 +62038,8 @@ relationship: RO:0002256 UBERON:0009881 ! anterior lateral plate mesoderm [Term] id: UBERON:0007010 name: cleaving embryo +def: "Organism at the cleavage stage." [OBOL:automatic] +xref: BILA:0000058 is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002489 UBERON:0000107 ! cleavage stage @@ -40671,6 +62050,9 @@ relationship: RO:0002493 UBERON:0000107 ! cleavage stage [Term] id: UBERON:0007026 name: presumptive gut +xref: BILA:0000084 +xref: NCIT:C34268 +xref: SCTID:360394002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001555 ! digestive tract @@ -40682,6 +62064,7 @@ relationship: RO:0002488 UBERON:0000109 ! gastrula stage [Term] id: UBERON:0007037 name: mechanosensory system +xref: BILA:0000142 is_a: UBERON:0001032 ! sensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: RO:0002215 GO:0050954 ! capable of sensory perception of mechanical stimulus @@ -40690,12 +62073,20 @@ relationship: RO:0002215 GO:0050954 ! capable of sensory perception of mechanica [Term] id: UBERON:0007098 name: mandibular neural crest +def: "Cranial neural crest that migrates into the mandibular arch." [ZFA:0007064] +xref: TAO:0007064 +xref: XAO:0000024 +xref: ZFA:0007064 is_a: UBERON:0003099 ! cranial neural crest relationship: BFO:0000050 UBERON:0003852 ! part of rhombencephalon neural crest [Term] id: UBERON:0007100 name: primary circulatory organ +def: "A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]." [GO:0007507] +comment: Gene notes: Bmp, Nkx, Gata +xref: http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg +xref: TADS:0000147 is_a: UBERON:0015228 ! circulatory organ intersection_of: UBERON:0015228 ! circulatory organ intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation @@ -40705,6 +62096,12 @@ relationship: RO:0002215 GO:0008015 ! capable of blood circulation [Term] id: UBERON:0007134 name: trunk ganglion +def: "Ganglion which is located in the trunk." [ZFIN:curator] +xref: EFO:0000901 +xref: MAT:0000344 +xref: MIAA:0000344 +xref: TAO:0001573 +xref: ZFA:0001573 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -40713,12 +62110,92 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0007135 name: neural keel +def: "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section." [ZFIN:ZDB-PUB-961014-576] +xref: EFO:0003497 +xref: TAO:0000131 +xref: ZFA:0000131 is_a: UBERON:0016879 ! future central nervous system relationship: RO:0002202 UBERON:0003075 ! neural plate +[Term] +id: UBERON:0007144 +name: embryonic post-anal tail +def: "An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:16748 +xref: FMA:85540 +is_a: UBERON:0002050 ! embryonic structure +relationship: RO:0002494 UBERON:0002533 ! post-anal tail bud + +[Term] +id: UBERON:0007147 +name: lumen of midgut +def: "An anatomical cavity that surrounded_by a midgut." [OBOL:automatic] +xref: EMAPA:18377 +xref: FMA:54366 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0001045 ! midgut +relationship: BFO:0000050 UBERON:0001045 ! part of midgut +relationship: RO:0002572 UBERON:0001045 ! midgut + +[Term] +id: UBERON:0007148 +name: lumen of hindgut +def: "An anatomical cavity that surrounded_by a hindgut." [OBOL:automatic] +xref: EMAPA:18396 +xref: FMA:54367 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0001046 ! hindgut +relationship: BFO:0000050 UBERON:0001046 ! part of hindgut +relationship: RO:0002572 UBERON:0001046 ! hindgut + +[Term] +id: UBERON:0007158 +name: lumen of anal canal +def: "An anatomical cavity that surrounded_by a anal canal." [OBOL:automatic] +xref: EMAPA:18836 +xref: FMA:17357 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0000159 ! anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: RO:0002572 UBERON:0000159 ! anal canal + +[Term] +id: UBERON:0007159 +name: lumen of colon +def: "An anatomical cavity that surrounded_by a colon." [OBOL:automatic] +xref: EMAPA:18945 +xref: FMA:18374 +xref: SCTID:362156004 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0001155 ! colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon +relationship: RO:0002572 UBERON:0001155 ! colon + +[Term] +id: UBERON:0007177 +name: lamina propria of mucosa of colon +def: "A lamina propria that is part of a colonic mucosa." [OBOL:automatic] +xref: EMAPA:27395 +xref: FMA:15657 +xref: MA:0003196 +xref: SCTID:113284008 +is_a: UBERON:0011189 ! lamina propria of large intestine +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: BFO:0000050 UBERON:0000317 ! part of colonic mucosa +relationship: BFO:0000050 UBERON:0000317 ! part of colonic mucosa + [Term] id: UBERON:0007188 name: mesothelium of serous pericardium +def: "A mesothelium that is part of a serous pericardium." [OBOL:automatic] +xref: BTO:0003157 +xref: EMAPA:16133 +xref: FMA:18149 +xref: SCTID:67300002 is_a: UBERON:0003388 ! mesothelium of pericardial cavity intersection_of: UBERON:0001136 ! mesothelium intersection_of: BFO:0000050 UBERON:0002357 ! part of serous pericardium @@ -40727,6 +62204,10 @@ relationship: BFO:0000050 UBERON:0002357 ! part of serous pericardium [Term] id: UBERON:0007195 name: stroma of bone marrow +def: "The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis." [Wikipedia:Bone_marrow#Stroma] +xref: CALOHA:TS-0085 +xref: FMA:21426 +xref: Wikipedia:Bone_marrow#Stroma is_a: UBERON:0003891 ! stroma is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003891 ! stroma @@ -40739,22 +62220,35 @@ relationship: BFO:0000051 UBERON:0003909 ! has part sinusoid [Term] id: UBERON:0007196 name: tracheobronchial tree +def: "The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells." [Wikipedia:Tracheobronchial_tree] +xref: FMA:7393 +xref: NCIT:C117875 +xref: SCTID:361384001 +xref: Wikipedia:Tracheobronchial_tree is_a: UBERON:0000062 ! organ is_a: UBERON:0004119 ! endoderm-derived structure relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract relationship: BFO:0000051 UBERON:0002185 ! has part bronchus relationship: BFO:0000051 UBERON:0003126 ! has part trachea relationship: BFO:0000051 UBERON:0007592 ! has part ciliated columnar epithelium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007204 name: brachiocephalic vasculature +def: "The vasculature consisting of brachiocephalic arteries and veins." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002049 ! vasculature [Term] id: UBERON:0007213 name: mesenchyme derived from head neural crest +def: "Mesenchyme that develops_from a cranial neural crest." [OBOL:automatic] +xref: EFO:0003572 +xref: EHDAA2:0000735 +xref: EMAPA:16169 +xref: EMAPA:16271 +xref: EMAPA_RETIRED:16271 +xref: TAO:0000787 +xref: ZFA:0000787 is_a: UBERON:0005253 ! head mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest intersection_of: UBERON:0003104 ! mesenchyme @@ -40764,6 +62258,11 @@ relationship: RO:0002202 UBERON:0003099 ! cranial neural crest [Term] id: UBERON:0007214 name: mesenchyme derived from trunk neural crest +def: "Mesenchyme that develops_from a trunk neural crest." [OBOL:automatic] +xref: EHDAA2:0002093 +xref: EMAPA:16182 +xref: TAO:0000999 +xref: ZFA:0000999 is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest intersection_of: UBERON:0003104 ! mesenchyme @@ -40773,12 +62272,31 @@ relationship: RO:0002202 UBERON:0003083 ! trunk neural crest [Term] id: UBERON:0007237 name: 1st arch mandibular component +xref: EHDAA2:0000031 +xref: EHDAA:583 +xref: EMAPA:16382 +xref: VHOG:0000510 +is_a: UBERON:0002050 ! embryonic structure +relationship: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 + +[Term] +id: UBERON:0007238 +name: 1st arch maxillary component +xref: EHDAA2:0000038 +xref: EHDAA:595 +xref: EMAPA:16388 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 [Term] id: UBERON:0007239 name: tunica media of artery +def: "A tunica media that is part of a artery." [OBOL:automatic] +xref: EMAPA:36294 +xref: EV:0100029 +xref: FMA:14273 +xref: NCIT:C49321 +xref: SCTID:84300001 is_a: UBERON:0002522 ! tunica media intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0001637 ! part of artery @@ -40787,6 +62305,11 @@ relationship: BFO:0000050 UBERON:0000415 ! part of artery wall [Term] id: UBERON:0007240 name: tunica adventitia of artery +def: "A tunica adventitia that is part of a artery." [OBOL:automatic] +xref: EMAPA:36295 +xref: EV:0100030 +xref: FMA:14274 +xref: SCTID:113261001 is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: BFO:0000050 UBERON:0001637 ! part of artery @@ -40796,6 +62319,11 @@ relationship: BFO:0000051 CL:1000306 ! has part fibroblast of tunica adventitia [Term] id: UBERON:0007241 name: tunica adventitia of vein +def: "A tunica adventitia that is part of a vein." [OBOL:automatic] +xref: EMAPA:36310 +xref: EV:0100034 +xref: FMA:14355 +xref: SCTID:13202006 is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: BFO:0000050 UBERON:0001638 ! part of vein @@ -40804,6 +62332,11 @@ relationship: BFO:0000050 UBERON:0001638 ! part of vein [Term] id: UBERON:0007242 name: tunica intima of vein +def: "A tunica intima that is part of a vein." [OBOL:automatic] +xref: EMAPA:36308 +xref: EV:0100032 +xref: FMA:14353 +xref: SCTID:2436009 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004797 ! blood vessel layer intersection_of: UBERON:0002523 ! tunica intima @@ -40813,6 +62346,11 @@ relationship: BFO:0000050 UBERON:0001638 ! part of vein [Term] id: UBERON:0007243 name: tunica media of vein +def: "A tunica media that is part of a vein." [OBOL:automatic] +xref: EMAPA:36309 +xref: EV:0100033 +xref: FMA:14354 +xref: SCTID:42049001 is_a: UBERON:0002522 ! tunica media intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0001638 ! part of vein @@ -40821,6 +62359,9 @@ relationship: BFO:0000050 UBERON:0001638 ! part of vein [Term] id: UBERON:0007245 name: nuclear complex of neuraxis +def: "Gray matter of the central nervous system which is a collection of clustered nuclei." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:256381 +xref: FMA:84059 is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: RO:0002473 UBERON:0000125 ! neural nucleus @@ -40829,6 +62370,9 @@ relationship: RO:0002473 UBERON:0000125 ! neural nucleus [Term] id: UBERON:0007247 name: nucleus of superior olivary complex +def: "Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:72246 +xref: SCTID:369024009 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus intersection_of: UBERON:0002308 ! nucleus of brain @@ -40838,6 +62382,9 @@ relationship: BFO:0000050 UBERON:0002128 ! part of superior olivary complex [Term] id: UBERON:0007267 name: trachea pre-cartilage rings +def: "A pre-cartilage condensation that is part of a trachea." [OBOL:automatic] +xref: EHDAA2:0002070 +xref: EHDAA:7082 is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0009505 ! mesenchyme of trachea intersection_of: UBERON:0005866 ! pre-cartilage condensation @@ -40847,6 +62394,10 @@ relationship: RO:0002202 UBERON:0009505 ! mesenchyme of trachea [Term] id: UBERON:0007269 name: pectoral appendage musculature +def: "Any collection of muscles that is part of a pectoral appendage." [OBOL:automatic] +xref: EFO:0003540 +xref: TAO:0000563 +xref: ZFA:0000563 is_a: UBERON:0007271 ! appendage musculature is_a: UBERON:0014793 ! musculature of pectoral complex intersection_of: UBERON:0001015 ! musculature @@ -40856,6 +62407,9 @@ relationship: BFO:0000050 UBERON:0004710 ! part of pectoral appendage [Term] id: UBERON:0007271 name: appendage musculature +def: "Any collection of muscles that is part of an appendage." [OBOL:automatic] +xref: TAO:0000207 +xref: ZFA:0000207 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000026 ! part of appendage @@ -40864,6 +62418,8 @@ relationship: BFO:0000050 UBERON:0000026 ! part of appendage [Term] id: UBERON:0007272 name: pectoral appendage skeleton +def: "Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle." [VSAO:0005000, VSAO:NI] +xref: VSAO:0005000 is_a: UBERON:0011582 ! paired limb/fin skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0004710 ! pectoral appendage @@ -40874,6 +62430,15 @@ relationship: RO:0002576 UBERON:0004710 ! pectoral appendage [Term] id: UBERON:0007277 name: presumptive hindbrain +def: "The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure." [Wikipedia:Rhombencephalon] +xref: BAMS:HB +xref: CALOHA:TS-2118 +xref: EFO:0003440 +xref: EHDAA2:0001630 +xref: FMA:295640 +xref: TAO:0000569 +xref: Wikipedia:Rhombencephalon +xref: ZFA:0000569 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002028 ! hindbrain @@ -40885,6 +62450,9 @@ relationship: RO:0002387 UBERON:0002028 ! hindbrain [Term] id: UBERON:0007278 name: presumptive sinus venosus +def: "Portion of tissue that is part of the heart tube and will become the sinus venosus." [ZFA:0001722] +xref: TAO:0002234 +xref: ZFA:0001722 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002063 ! sinus venosus @@ -40894,6 +62462,9 @@ relationship: RO:0002387 UBERON:0002063 ! sinus venosus [Term] id: UBERON:0007280 name: presumptive endocardium +def: "A presumptive structure that has the potential to develop into a endocardium." [OBOL:automatic] +xref: TAO:0002233 +xref: ZFA:0001724 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002165 ! endocardium @@ -40904,6 +62475,11 @@ relationship: RO:0002387 UBERON:0002165 ! endocardium [Term] id: UBERON:0007281 name: presumptive midbrain hindbrain boundary +def: "Embryonic structure that gives rise to the midbrain hindbrain boundary." [ZFA:0001187] +xref: EFO:0003446 +xref: TAO:0001187 +xref: XAO:0004086 +xref: ZFA:0001187 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003052 ! midbrain-hindbrain boundary @@ -40913,6 +62489,10 @@ relationship: RO:0002387 UBERON:0003052 ! midbrain-hindbrain boundary [Term] id: UBERON:0007282 name: presumptive segmental plate +def: "A presumptive structure that has the potential to develop into a presomitic mesoderm." [OBOL:automatic] +xref: EFO:0003421 +xref: TAO:0000053 +xref: ZFA:0000053 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003059 ! presomitic mesoderm @@ -40922,6 +62502,10 @@ relationship: RO:0002387 UBERON:0003059 ! presomitic mesoderm [Term] id: UBERON:0007284 name: presumptive neural plate +def: "A presumptive structure that has the potential to develop into a neural plate." [OBOL:automatic] +xref: EFO:0003424 +xref: TAO:0000063 +xref: ZFA:0000063 is_a: UBERON:0016879 ! future central nervous system intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003075 ! neural plate @@ -40932,6 +62516,11 @@ relationship: RO:0002387 UBERON:0003075 ! neural plate [Term] id: UBERON:0007285 name: presumptive paraxial mesoderm +def: "The part of the blastula that has the potential to develop into a paraxial mesoderm." [https://github.com/obophenotype/uberon/issues/1277, UBERON:cjm] +xref: EFO:0003443 +xref: TAO:0000591 +xref: XAO:0004134 +xref: ZFA:0000591 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0000307 ! part of blastula relationship: RO:0002387 UBERON:0003077 ! paraxial mesoderm @@ -40939,6 +62528,9 @@ relationship: RO:0002387 UBERON:0003077 ! paraxial mesoderm [Term] id: UBERON:0007300 name: pectoral appendage blood vessel +def: "A blood vessel that is part of a pectoral appendage." [OBOL:automatic] +xref: TAO:0005301 +xref: ZFA:0005301 is_a: UBERON:0007301 ! appendage blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage @@ -40947,6 +62539,9 @@ relationship: BFO:0000050 UBERON:0004710 ! part of pectoral appendage [Term] id: UBERON:0007301 name: appendage blood vessel +def: "A blood vessel that is part of a limb/fin." [OBOL:automatic] +xref: TAO:0005299 +xref: ZFA:0005299 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000026 ! part of appendage @@ -40955,6 +62550,9 @@ relationship: BFO:0000050 UBERON:0007304 ! part of appendage vasculature [Term] id: UBERON:0007302 name: pectoral appendage vasculature +def: "A vasculature that is part of a pectoral appendage." [OBOL:automatic] +xref: TAO:0005096 +xref: ZFA:0005096 is_a: UBERON:0007304 ! appendage vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage @@ -40963,6 +62561,9 @@ relationship: BFO:0000050 UBERON:0004710 ! part of pectoral appendage [Term] id: UBERON:0007303 name: pharyngeal vasculature +def: "A vasculature that is part of a chordate pharynx." [OBOL:automatic] +xref: TAO:0005003 +xref: ZFA:0005003 is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx @@ -40971,14 +62572,68 @@ relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx [Term] id: UBERON:0007304 name: appendage vasculature +def: "A vasculature that is part of a limb/fin." [OBOL:automatic] +xref: TAO:0005095 +xref: ZFA:0005095 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000026 ! part of appendage relationship: BFO:0000050 UBERON:0000026 ! part of appendage +[Term] +id: UBERON:0007324 +name: pancreatic lobule +def: "A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans." [ISBN:0123813611] +xref: FMA:16012 +xref: MA:0000721 +is_a: UBERON:0000064 ! organ part +is_a: UBERON:0004119 ! endoderm-derived structure +relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000051 UBERON:0001263 ! has part pancreatic acinus +relationship: BFO:0000051 UBERON:0014719 ! has part intralobular duct + +[Term] +id: UBERON:0007329 +name: pancreatic duct +def: "A duct that collects and carries secretions of the exocrine pancreas to the intestine." [GOC:cvs, GOC:ymb, https://github.com/obophenotype/uberon/issues/1250, https://orcid.org/0000-0002-2244-7917, https://orcid.org/0000-0002-6601-2165, https://orcid.org/0000-0002-9900-7880, Wikipedia:Pancreatic_duct] +xref: EHDAA:9194 +xref: EMAPA:32952 +xref: FMA:10419 +xref: MA:0000124 +xref: SCTID:181278006 +xref: TAO:0001372 +xref: VHOG:0000254 +xref: Wikipedia:Pancreatic_duct +xref: ZFA:0001372 +is_a: UBERON:0003928 ! digestive system duct +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000058 ! duct +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +intersection_of: RO:0002170 UBERON:0000160 ! intestine +relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: RO:0002170 UBERON:0000160 ! intestine +relationship: RO:0002202 UBERON:0003922 ! pancreatic epithelial bud +relationship: RO:0002433 UBERON:0000017 ! exocrine pancreas + +[Term] +id: UBERON:0007375 +name: roof of mouth +def: "A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones." [https://orcid.org/0000-0002-6601-2165] +xref: CALOHA:TS-2212 +xref: Wikipedia:Palate +is_a: UBERON:0000481 ! multi-tissue structure +relationship: BFO:0000050 UBERON:0000033 ! part of head + [Term] id: UBERON:0007376 name: outer epithelium +def: "The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]." [GO:0008544] +xref: BSA:0000073 +xref: BTO:0000313 +xref: HAO:0000298 +xref: TADS:0000109 +xref: WBbt:0005733 +xref: Wikipedia:Epidermis_(zoology) is_a: UBERON:0003102 ! surface structure is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium @@ -40991,6 +62646,10 @@ relationship: RO:0002202 UBERON:0007383 ! enveloping layer of ectoderm [Term] id: UBERON:0007383 name: enveloping layer of ectoderm +def: "Outermost layer of cells surrounding the embryo." [http://orcid.org/0000-0002-6601-2165] +xref: EFO:0003425 +xref: TAO:0000086 +xref: ZFA:0000086 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium @@ -41000,6 +62659,9 @@ relationship: RO:0002202 UBERON:0000076 ! external ectoderm [Term] id: UBERON:0007389 name: paired limb/fin cartilage +def: "A cartilage tissue that is part of a paired limb or fin." [http://orcid.org/0000-0002-6601-2165] +xref: TAO:0001543 +xref: ZFA:0001543 is_a: UBERON:0002418 ! cartilage tissue intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: BFO:0000050 UBERON:0004708 ! part of paired limb/fin @@ -41009,6 +62671,9 @@ relationship: BFO:0000050 UBERON:0004708 ! part of paired limb/fin [Term] id: UBERON:0007390 name: pectoral appendage cartilage tissue +def: "A cartilage tissue that is part of a pectoral appendage." [OBOL:automatic] +xref: TAO:0000257 +xref: ZFA:0000257 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007389 ! paired limb/fin cartilage intersection_of: UBERON:0002418 ! cartilage tissue @@ -41019,6 +62684,9 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0007414 name: nucleus of midbrain tegmentum +def: "A nucleus of brain that spans a midbrain tegmentum." [OBOL:automatic] +xref: FMA:258768 +xref: ZFA:0005577 is_a: UBERON:0000125 ! neural nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: RO:0002131 UBERON:0001943 ! overlaps midbrain tegmentum @@ -41027,6 +62695,8 @@ relationship: RO:0002131 UBERON:0001943 ! overlaps midbrain tegmentum [Term] id: UBERON:0007473 name: lumen of epithelial sac +def: "The space within an epithelial sphere." [AEO:JB] +xref: AEO:0000079 is_a: UBERON:0012467 ! enclosed anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0007499 ! epithelial sac @@ -41035,6 +62705,9 @@ relationship: RO:0002572 UBERON:0007499 ! epithelial sac [Term] id: UBERON:0007475 name: matrix-based tissue +def: "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified." [AEO:JB] +xref: AEO:0000081 +xref: EHDAA2:0003081 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002473 GO:0031012 ! extracellular matrix @@ -41043,6 +62716,9 @@ relationship: RO:0002473 GO:0031012 ! extracellular matrix [Term] id: UBERON:0007499 name: epithelial sac +def: "An epithelial tube that is open at one end only." [AEO:JB, UBERONREF:0000001] +xref: AEO:0000115 +xref: EHDAA2:0003115 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0009856 ! sac intersection_of: UBERON:0000483 ! epithelium @@ -41051,22 +62727,59 @@ intersection_of: RO:0000086 PATO:0001987 [Term] id: UBERON:0007500 name: epithelial tube open at both ends +def: "An epithelial tube open at both ends that allows fluid flow." [AEO:JB, UBERONREF:0000001] +xref: AEO_RETIRED:0000116 +xref: RETIRED_EHDAA2:0003116 is_a: UBERON:0003914 ! epithelial tube [Term] id: UBERON:0007503 name: epithelial vesicle +def: "A closed epithelium with a lumen." [AEO:JB] +xref: AEO:0000119 +xref: EHDAA2:0003119 is_a: UBERON:0000483 ! epithelium +[Term] +id: UBERON:0007521 +name: smooth muscle sphincter +def: "A ring of smooth muscle cells whose contraction closes the opening of the ring." [AEO:JB] +xref: AEO:0000143 +xref: EHDAA2:0003143 +xref: SCTID:362915001 +is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000051 CL:0000192 ! has part smooth muscle cell +relationship: BFO:0000051 CL:0000192 ! has part smooth muscle cell +relationship: RO:0002473 UBERON:0001135 ! smooth muscle tissue + +[Term] +id: UBERON:0007522 +name: striated muscle sphincter +def: "A ring of striated muscle cells whose contraction closes the opening of the ring." [AEO:JB] +xref: AEO:0000144 +xref: EHDAA2:0003144 +is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000051 CL:0000737 ! has part striated muscle cell +relationship: BFO:0000051 CL:0000737 ! has part striated muscle cell +relationship: RO:0002473 UBERON:0002036 ! striated muscle tissue + [Term] id: UBERON:0007524 name: dense mesenchyme tissue +def: "Mesenchyme with little extracellular matrix." [AEO:JB] +xref: AEO:0000146 +xref: EHDAA2:0003146 is_a: UBERON:0003104 ! mesenchyme relationship: BFO:0000051 CL:0000057 ! has part fibroblast [Term] id: UBERON:0007530 name: migrating mesenchyme population +def: "Mesenchymal cells that are migrating." [AEO:JB] +xref: AEO:0000152 +xref: EHDAA2:0003152 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0000056 GO:0016477 ! participates in cell migration @@ -41075,6 +62788,8 @@ relationship: RO:0000056 GO:0016477 ! participates in cell migration [Term] id: UBERON:0007592 name: ciliated columnar epithelium +def: "Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]." [FMA:64798] +xref: FMA:64798 is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0007601 ! ciliated epithelium intersection_of: UBERON:0000485 ! simple columnar epithelium @@ -41083,6 +62798,7 @@ intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell [Term] id: UBERON:0007601 name: ciliated epithelium +def: "Epithelium bearing vibratile cilia on the free surface." [http://medical-dictionary.thefreedictionary.com/ciliated+epithelium] is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell @@ -41091,6 +62807,10 @@ relationship: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell [Term] id: UBERON:0007616 name: layer of synovial tissue +def: "A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]." [BTO:0001338, http://www.britannica.com/EBchecked/topic/578563/synovial-tissue] +xref: BTO:0001338 +xref: CALOHA:TS-0998 +xref: FMA:66762 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: RO:0003000 UBERON:0001090 ! produces synovial fluid @@ -41100,6 +62820,8 @@ relationship: RO:0003000 UBERON:0001090 ! produces synovial fluid [Term] id: UBERON:0007617 name: synovial cavity of joint +def: "An anatomical cavity that surrounded_by a synovial joint." [OBOL:automatic] +xref: FMA:11356 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002217 ! synovial joint @@ -41108,6 +62830,9 @@ relationship: RO:0002572 UBERON:0002217 ! synovial joint [Term] id: UBERON:0007625 name: pigment epithelium of eye +def: "Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules." [MP:0005200] +xref: GAID:907 +xref: MESH:D010857 is_a: UBERON:0019304 ! sensory organ epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000970 ! part of eye @@ -41116,6 +62841,9 @@ relationship: BFO:0000050 UBERON:0000970 ! part of eye [Term] id: UBERON:0007635 name: nucleus of medulla oblongata +def: "A neural nucleus that is part of a medulla oblongata." [OBOL:automatic] +xref: FMA:258772 +xref: SCTID:304943004 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus intersection_of: UBERON:0000125 ! neural nucleus @@ -41125,6 +62853,15 @@ relationship: BFO:0000050 UBERON:0001896 ! part of medulla oblongata [Term] id: UBERON:0007641 name: trigeminal nuclear complex +def: "The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]." [Wikipedia:Trigeminal_nerve_nuclei] +xref: BIRNLEX:4096 +xref: BM:V +xref: CALOHA:TS-2077 +xref: DHBA:266441713 +xref: FMA:71248 +xref: HBA:9203 +xref: neuronames:2021 +xref: Wikipedia:Trigeminal_nerve_nuclei is_a: UBERON:0007245 ! nuclear complex of neuraxis relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve relationship: RO:0002131 UBERON:0003023 ! overlaps pontine tegmentum @@ -41132,21 +62869,42 @@ relationship: RO:0002131 UBERON:0003023 ! overlaps pontine tegmentum [Term] id: UBERON:0007651 name: anatomical junction +def: "An anatomical structure that connects two structures." [http://code.google.com/p/caro2/issues/detail?id=15] +xref: FMA:5898 +xref: SCTID:91833003 is_a: UBERON:0000061 ! anatomical structure relationship: RO:0002176 UBERON:0000061 {minCardinality="2"} ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 + +[Term] +id: UBERON:0007652 +name: esophageal sphincter +def: "A sphincter that is part of an esophagus." [http://orcid.org/0000-0002-6601-2165] +xref: SCTID:277765007 +is_a: UBERON:0003832 ! esophagus muscle +is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus [Term] id: UBERON:0007688 name: anlage +def: "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue." [FBbt:00005426, http://flybase.org/reports/FBrf0178740.html] +xref: AEO:0000170 +xref: EFO:0001649 +xref: EHDAA2:0003170 +xref: Wikipedia:Anlage_(biology) is_a: UBERON:0000479 ! tissue is_a: UBERON:0005423 ! developing anatomical structure [Term] id: UBERON:0007690 name: early pharyngeal endoderm +comment: relation conflict: ZFA vs EHDAA2. Note EHDAA2 term renamed to 'early PA endoderm' +xref: EFO:0003626 +xref: EHDAA2:0001457 +xref: EHDAA:962 +xref: TAO:0001104 +xref: ZFA:0001104 is_a: UBERON:0003258 ! endoderm of foregut is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0009722 ! part of entire pharyngeal arch endoderm @@ -41154,6 +62912,7 @@ relationship: BFO:0000050 UBERON:0009722 ! part of entire pharyngeal arch endode [Term] id: UBERON:0007719 name: bone of reproductive organ +def: "A bone that is part of a reproductive organ." [https://github.com/obophenotype/uberon/issues/1158, OBOL:automatic] is_a: UBERON:0001474 ! bone element is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001474 ! bone element @@ -41163,6 +62922,8 @@ relationship: BFO:0000050 UBERON:0003133 ! part of reproductive organ [Term] id: UBERON:0007771 name: epidermis gland +def: "A gland that is part of a epidermis." [OBOL:automatic] +xref: FMA:59153 is_a: UBERON:0002419 ! skin gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis @@ -41171,6 +62932,11 @@ relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis [Term] id: UBERON:0007779 name: transudate +def: "Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces." [http://medical-dictionary.thefreedictionary.com/transudate] +xref: FMA:12276 +xref: GAID:1195 +xref: MESH:D005122 +xref: ncithesaurus:Transudate is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: filtered_through UBERON:0001982 ! capillary @@ -41183,6 +62949,8 @@ relationship: RO:0002494 UBERON:0001969 ! blood plasma [Term] id: UBERON:0007794 name: secretion of serous gland +def: "Any fluid produced by a serous gland." [UBERON:cjm] +xref: Wikipedia:Serous_fluid is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid @@ -41192,13 +62960,22 @@ relationship: RO:0003001 UBERON:0000409 ! produced by serous gland [Term] id: UBERON:0007798 name: vascular system +def: "Anatomical system that consists of all blood and lymph vessels." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0001085 +xref: CALOHA:TS-2053 +xref: EHDAA2:0004520 +xref: EMAPA:35905 +xref: MA:0002718 +xref: NCIT:C33854 is_a: UBERON:0000467 ! anatomical system relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007808 name: adipose tissue of abdominal region +def: "Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots." [CALOHA:paula, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/259, MGI:csmith] +xref: CALOHA:TS-0002 +xref: EFO:0003771 is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003567 ! abdomen connective tissue intersection_of: UBERON:0001013 ! adipose tissue @@ -41207,6 +62984,15 @@ intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0007811 name: craniocervical region +def: "The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae." [https://orcid.org/0000-0002-6601-2165] +xref: CALOHA:TS-2356 +xref: EV:0100009 +xref: FMA:280881 +xref: galen:HeadAndNeck +xref: MA:0000006 +xref: NCIT:C12418 +xref: SCTID:361355005 +xref: WikipediaCategory:Head_and_neck is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0000153 ! part of anterior region of body relationship: BFO:0000050 UBERON:0013702 ! part of body proper @@ -41214,9 +63000,30 @@ relationship: BFO:0000051 UBERON:0000033 ! has part head relationship: BFO:0000051 UBERON:0000974 {gci_filler="NCBITaxon:32523", gci_relation="BFO:0000050"} ! has part neck relationship: BFO:0000051 UBERON:0006562 ! has part pharynx +[Term] +id: UBERON:0007812 +name: post-anal tail +def: "A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0010338 +xref: MA:0000008 +xref: NCIT:C77663 +xref: TAO:0001117 +xref: XAO:0003026 +xref: ZFA:0001117 +is_a: UBERON:0002415 ! tail +intersection_of: UBERON:0002415 ! tail +intersection_of: BFO:0000050 UBERON:0006071 ! part of caudal region +relationship: BFO:0000050 UBERON:0006071 ! part of caudal region +relationship: RO:0002160 NCBITaxon:7711 ! Chordata +relationship: RO:0002216 GO:0007626 ! capable of part of locomotory behavior +relationship: RO:0002494 UBERON:0007144 ! embryonic post-anal tail + [Term] id: UBERON:0007823 name: appendage girdle region +def: "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: FMA:24874 +xref: VSAO:0000303 is_a: UBERON:0000475 ! organism subdivision intersection_of: UBERON:0000475 ! organism subdivision intersection_of: RO:0002551 UBERON:0010719 ! girdle skeleton @@ -41224,9 +63031,26 @@ relationship: BFO:0000050 UBERON:0010707 ! part of appendage girdle complex relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002551 UBERON:0010719 ! girdle skeleton +[Term] +id: UBERON:0007826 +name: peritoneal mesentery +def: "Mesentery that is located in the peritoneum." [UBERON:cjm] +xref: FMA:20570 +xref: TAO:0005129 +xref: XAO:0000138 +xref: ZFA:0005129 +is_a: UBERON:0002095 ! mesentery +is_a: UBERON:0002358 ! peritoneum +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum +relationship: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum + [Term] id: UBERON:0007828 name: girdle bone/zone +def: "A bone that is part of a appendage girdle region." [OBOL:automatic] +xref: EMAPA:35379 +xref: MA:0000291 is_a: UBERON:0010740 ! bone of appendage girdle complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0007823 ! part of appendage girdle region @@ -41235,16 +63059,33 @@ relationship: BFO:0000050 UBERON:0010719 ! part of girdle skeleton [Term] id: UBERON:0007829 name: pectoral girdle bone +def: "A bone that is part of a pectoral girdle region." [OBOL:automatic] +xref: EMAPA:35669 +xref: MA:0000292 is_a: UBERON:0007828 ! girdle bone/zone is_a: UBERON:0010741 ! bone of pectoral complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region relationship: BFO:0000050 UBERON:0007831 ! part of pectoral girdle skeleton -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007831 name: pectoral girdle skeleton +def: "A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons." [Wikipedia:Pectoral_girdle] +xref: AAO:0000422 +xref: AAO:0000754 +xref: EFO:0000946 +xref: EHDAA2:0001420 +xref: FMA:24141 +xref: MAT:0000181 +xref: MIAA:0000181 +xref: NCIT:C33547 +xref: TAO:0000407 +xref: VHOG:0001156 +xref: VSAO:0000156 +xref: Wikipedia:Pectoral_girdle +xref: XAO:0003063 +xref: ZFA:0000407 is_a: UBERON:0010719 ! girdle skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region @@ -41256,12 +63097,26 @@ relationship: RO:0002576 UBERON:0001421 ! pectoral girdle region [Term] id: UBERON:0007842 name: membrane bone +def: "Bone element that arises as a result of intramembranous ossification." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/267, VSAO:0000023] +xref: AEO:0000085 +xref: EHDAA2:0003085 +xref: TAO:0001645 +xref: VSAO:0000023 +xref: XAO:0004014 +xref: ZFA:0001636 is_a: UBERON:0001474 ! bone element relationship: RO:0002353 GO:0001957 ! output of intramembranous ossification [Term] id: UBERON:0007844 name: cartilage element +def: "Skeletal element that is composed of cartilage tissue and may be permanent or transient." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000000] +xref: AAO:0011130 +xref: CALOHA:TS-0118 +xref: FMA:55107 +xref: VSAO:0000000 +xref: XAO:0004013 +xref: ZFA:0001501 is_a: UBERON:0004765 ! skeletal element intersection_of: UBERON:0004765 ! skeletal element intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue @@ -41272,6 +63127,8 @@ relationship: RO:0002473 UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0007845 name: regular connective tissue +def: "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue." [FMA:20103] +xref: FMA:20103 is_a: UBERON:0002384 ! connective tissue disjoint_from: UBERON:0011821 ! irregular connective tissue relationship: BFO:0000051 CL:0000057 ! has part fibroblast @@ -41281,6 +63138,13 @@ relationship: BFO:0000051 UBERON:0011860 ! has part collection of collagen fibri [Term] id: UBERON:0007846 name: dense regular connective tissue +def: "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts)." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000050] +xref: FMA:64781 +xref: NCIT:C33453 +xref: SCTID:22560007 +xref: VSAO:0000050 +xref: Wikipedia:Dense_regular_connective_tissue +xref: XAO:0004030 is_a: UBERON:0007845 ! regular connective tissue is_a: UBERON:0011823 ! dense connective tissue intersection_of: UBERON:0007845 ! regular connective tissue @@ -41290,14 +63154,28 @@ intersection_of: RO:0002473 UBERON:0011860 ! collection of collagen fibrils [Term] id: UBERON:0007914 name: bone of craniocervical region +def: "A bone that is part of a craniocervical region." [OBOL:automatic] +xref: MA:0000569 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region +[Term] +id: UBERON:0008001 +name: irregular bone +def: "The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid." [Wikipedia:Irregular_bone] +xref: FMA:7477 +xref: NCIT:C32881 +xref: SCTID:421560006 +xref: Wikipedia:Irregular_bone +is_a: UBERON:0001474 ! bone element + [Term] id: UBERON:0008114 name: joint of girdle +def: "A skeletal joint that is part of a appendage girdle region." [OBOL:automatic] +xref: MA:0001505 is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: BFO:0000050 UBERON:0007823 ! part of appendage girdle region @@ -41308,14 +63186,31 @@ relationship: RO:0002176 UBERON:0007828 ! girdle bone/zone [Term] id: UBERON:0008115 name: surface of cartilage +def: "An anatomical surface that is part of a cartilage element." [OBOL:automatic] +xref: FMA:76668 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: RO:0002007 UBERON:0007844 ! bounding layer of cartilage element relationship: RO:0002007 UBERON:0007844 ! bounding layer of cartilage element +[Term] +id: UBERON:0008193 +name: pneumatized bone +def: "A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]." [http://www.medilexicon.com/medicaldictionary.php?t=11303] +xref: FMA:7478 +xref: galen:PneumaticBone +xref: SCTID:333008005 +xref: Wikipedia:Skeletal_pneumaticity +is_a: UBERON:0001474 ! bone element +intersection_of: UBERON:0001474 ! bone element +intersection_of: BFO:0000051 UBERON:0010528 ! has part pneumatic cavity of bone +relationship: BFO:0000051 UBERON:0010528 ! has part pneumatic cavity of bone + [Term] id: UBERON:0008196 name: muscle of pectoral girdle +def: "Any muscle organ that is part of a pectoral girdle region." [OBOL:automatic] +xref: FMA:37347 is_a: UBERON:0010891 ! pectoral complex muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region @@ -41324,6 +63219,10 @@ relationship: BFO:0000050 UBERON:0004471 ! part of musculature of pectoral girdl [Term] id: UBERON:0008229 name: craniocervical region musculature +def: "Musculature system of the pharyngeal and head regions." [ZFA:0000328, ZFA:curator] +xref: MA:0000571 +xref: TAO:0000328 +xref: ZFA:0000328 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region @@ -41332,6 +63231,10 @@ relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region [Term] id: UBERON:0008231 name: dorsal thoracic segment of trunk +def: "Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax." [FMA:24217] +xref: FMA:24217 +xref: MA:0000028 +xref: SCTID:362666008 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0011270 ! part of dorsal trunk @@ -41339,6 +63242,9 @@ relationship: BFO:0000050 UBERON:0011270 ! part of dorsal trunk [Term] id: UBERON:0008243 name: upper back muscle +def: "A muscle of back that is part of a dorsal thoracic segment of trunk." [OBOL:automatic] +xref: MA:0000508 +xref: SCTID:305071003 is_a: UBERON:0002324 ! muscle of back is_a: UBERON:0003830 ! thoracic segment muscle intersection_of: UBERON:0002324 ! muscle of back @@ -41348,6 +63254,8 @@ relationship: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of tr [Term] id: UBERON:0008307 name: heart endothelium +def: "An endothelium that is part of a heart [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004293 is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0000948 ! part of heart @@ -41356,14 +63264,42 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: UBERON:0008339 name: microvascular endothelium +xref: BTO:0003122 is_a: UBERON:0004638 ! blood vessel endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:8410081 ! part of blood microvessel relationship: BFO:0000050 UBERON:8410081 ! part of blood microvessel +[Term] +id: UBERON:0008342 +name: intestinal villus of duodenum +def: "An intestinal villus in the duodenum." [OBOL:automatic] +xref: FMA:63300 +is_a: UBERON:0001213 ! intestinal villus +intersection_of: UBERON:0001213 ! intestinal villus +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0000320 ! part of duodenal mucosa + +[Term] +id: UBERON:0008346 +name: duodenal epithelium +def: "An epithelium that is part of a duodenum." [OBOL:automatic] +xref: CALOHA:TS-2087 +xref: EMAPA:19078 +xref: FMA:17231 +xref: MA:0003208 +xref: SCTID:66036002 +is_a: UBERON:0013636 ! epithelium of intestinal villus +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0008342 ! part of intestinal villus of duodenum + [Term] id: UBERON:0008397 name: tracheobronchial epithelium +def: "Epithelium pertaining to the trachea and bronchi." [Dorlands_Medical_Dictionary:MerckMedicus] +xref: BTO:0002925 +xref: CALOHA:TS-1063 is_a: UBERON:0004815 ! lower respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree @@ -41372,6 +63308,13 @@ relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree [Term] id: UBERON:0008780 name: inner cell mass derived epiblast +def: "An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers." [MP:0003886] +comment: The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5. +xref: EHDAA2:0000444 +xref: EHDAA:42 +xref: EHDAA:75 +xref: EMAPA:16050 +xref: NCIT:C34164 is_a: UBERON:0002532 ! epiblast (generic) intersection_of: UBERON:0002532 ! epiblast (generic) intersection_of: RO:0002202 UBERON:0000087 ! inner cell mass @@ -41381,6 +63324,10 @@ relationship: RO:0002202 UBERON:0000087 ! inner cell mass [Term] id: UBERON:0008814 name: pharyngeal arch system +def: "A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]." [GO:0060037, GOC:dph] +xref: EHDAA2:0000187 +xref: FMA:293041 +xref: NCIT:C34248 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0009145 ! part of pharyngeal region of foregut @@ -41389,6 +63336,9 @@ relationship: RO:0002160 NCBITaxon:7711 ! Chordata [Term] id: UBERON:0008816 name: embryonic head +def: "A head that is part of a embryo." [OBOL:automatic] +xref: CALOHA:TS-0246 +xref: FMA:293011 is_a: UBERON:0000033 ! head intersection_of: UBERON:0000033 ! head intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -41397,6 +63347,7 @@ relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: UBERON:0008823 name: neural tube derived brain +def: "A brain that develops_from a neural tube." [https://github.com/obophenotype/uberon/issues/338, OBOL:automatic] is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0000955 ! brain intersection_of: UBERON:0000955 ! brain @@ -41407,24 +63358,106 @@ relationship: RO:0002202 UBERON:0001049 ! neural tube [Term] id: UBERON:0008826 name: pulmonary surfactant +def: "A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein)." [Wikipedia:Pulmonary_surfactant] +xref: EMAPA:36551 +xref: FMA:62780 +xref: MA:0002534 +xref: NCIT:C13273 +xref: Wikipedia:Pulmonary_surfactant is_a: UBERON:0006538 ! respiratory system fluid/secretion intersection_of: UBERON:0006538 ! respiratory system fluid/secretion intersection_of: RO:0003001 CL:0002063 ! produced by pulmonary alveolar type 2 cell relationship: BFO:0000051 CHEBI:6495 ! has part relationship: RO:0003001 CL:0002063 ! produced by pulmonary alveolar type 2 cell +[Term] +id: UBERON:0008835 +name: hepatic diverticulum +def: "An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts." [http://www.stembook.org/node/512, MP:MP] +xref: AAO:0011057 +xref: EHDAA2:0000740 +xref: EHDAA:1530 +xref: NCIT:C34187 +xref: Wikipedia:Hepatic_diverticulum +xref: XAO:0000101 +is_a: UBERON:0004185 ! endodermal part of digestive tract +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0007499 ! epithelial sac +is_a: UBERON:0009497 ! epithelium of foregut-midgut junction +is_a: UBERON:0009854 ! digestive tract diverticulum +relationship: BFO:0000050 UBERON:0004161 ! part of septum transversum +relationship: RO:0002202 UBERON:0003894 ! liver primordium + +[Term] +id: UBERON:0008836 +name: liver bud +xref: BTO:0001642 +is_a: UBERON:0004185 ! endodermal part of digestive tract +is_a: UBERON:0007499 ! epithelial sac +is_a: UBERON:0009497 ! epithelium of foregut-midgut junction +is_a: UBERON:0009854 ! digestive tract diverticulum +relationship: RO:0002202 UBERON:0008835 ! hepatic diverticulum + [Term] id: UBERON:0008851 name: ectoplacental cavity +def: "Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals." [http://www.medilexicon.com/medicaldictionary.php?s=epamniotic+cavity, MP:0011207] +xref: EMAPA:16080 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0004364 ! ectoplacental cone relationship: BFO:0000050 UBERON:0004364 ! part of ectoplacental cone relationship: RO:0002572 UBERON:0004364 ! ectoplacental cone +[Term] +id: UBERON:0008856 +name: stomach muscularis externa +def: "The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines." [MP:0010779] +xref: FMA:14909 +xref: SCTID:362132003 +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0018261 ! muscular coat of digestive tract +is_a: UBERON:0034933 ! layer of smooth muscle tissue +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001167 ! part of wall of stomach +relationship: BFO:0000050 UBERON:0004222 ! part of stomach smooth muscle +relationship: RO:0002433 UBERON:0001135 ! smooth muscle tissue +relationship: RO:0002433 UBERON:0001167 ! wall of stomach + +[Term] +id: UBERON:0008858 +name: pyloric canal +def: "The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter." [MP:0010791, Wikipedia:Pyloric_canal] +xref: FMA:14580 +xref: SCTID:245417002 +xref: Wikipedia:Pyloric_canal +is_a: UBERON:0009870 ! zone of stomach +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: RO:0002150 UBERON:0001165 ! pyloric antrum +relationship: RO:0002150 UBERON:0001202 ! pyloric sphincter +relationship: RO:0002433 UBERON:0001166 ! pylorus + +[Term] +id: UBERON:0008861 +name: pyloric gastric gland +def: "The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]." [MP:0010797, Wikipedia:Pyloric_gland] +xref: EMAPA:27211 +xref: FMA:14922 +xref: NCIT:C33431 +xref: SCTID:70710007 +xref: Wikipedia:Pyloric_gland +is_a: UBERON:0000325 ! gastric gland +is_a: UBERON:0000414 ! mucous gland +intersection_of: UBERON:0000325 ! gastric gland +intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000050 UBERON:0004998 ! part of mucosa of pylorus +relationship: RO:0000086 PATO:0002299 +relationship: RO:0002433 UBERON:0001166 ! pylorus + [Term] id: UBERON:0008870 name: pulmonary alveolar parenchyma +def: "The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages." [MP:0010901] is_a: UBERON:0008946 ! lung parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0002299 ! part of alveolus of lung @@ -41433,20 +63466,26 @@ relationship: BFO:0000051 CL:0002062 ! has part pulmonary alveolar type 1 cell relationship: BFO:0000051 CL:0002063 ! has part pulmonary alveolar type 2 cell relationship: BFO:0000051 CL:0009089 ! has part lung pericyte relationship: RO:0002433 UBERON:0006524 ! alveolar system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008874 name: pulmonary acinus +def: "The largest lung subunit in which all airways participate in gas exchange, and it is composed of the parenchyma of the respiratory bronchioles, alveolar ducts, and alveoli." [MP:0010911, PMID:2014492, PMID:3382030, Wikipedia:Acinus#The_Lungs] +xref: FMA:7313 +xref: NCIT:C33426 +xref: SCTID:361365004 +xref: Wikipedia:Acinus#The_Lungs is_a: BFO:0000004 is_a: UBERON:0001062 ! anatomical entity relationship: BFO:0000050 UBERON:0010369 ! part of secondary pulmonary lobule relationship: RO:0002170 UBERON:0002187 ! terminal bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008876 name: hypodermis skeletal muscle layer +def: "Any skeletal muscle organ in the hypodermis / superficial fascia." [ISBN:0123813611, MP:0011157] +xref: EMAPA:18188 +xref: MA:0003140 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004253 ! skin muscle is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate @@ -41461,24 +63500,40 @@ relationship: RO:0002433 UBERON:0002072 ! hypodermis [Term] id: UBERON:0008886 name: pulmonary vascular system +def: "The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins." [ISBN:0073040584, Wikipedia:Pulmonary_circulation] +xref: FMA:45621 +xref: Wikipedia:Pulmonary_circulation is_a: UBERON:0007798 ! vascular system relationship: BFO:0000051 UBERON:0002012 ! has part pulmonary artery relationship: BFO:0000051 UBERON:0002016 ! has part pulmonary vein -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008895 name: splanchnocranium +def: "Subdivision of endoskeleton derived from pharyngeal arches." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584, Wikipedia:Facial_skeleton] +xref: AAO:0010157 +xref: TAO:0001216 +xref: VHOG:0000315 +xref: VSAO:0000149 +xref: Wikipedia:Facial_skeleton +xref: XAO:0003176 +xref: ZFA:0001216 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system disjoint_from: UBERON:0011156 ! facial skeleton relationship: RO:0002131 UBERON:0011156 {gci_filler="NCBITaxon:89593", gci_relation="BFO:0000050"} ! overlaps facial skeleton relationship: RO:0002202 UBERON:0002539 ! pharyngeal arch relationship: RO:0002254 UBERON:0003099 ! cranial neural crest -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008907 name: dermal bone +def: "Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/267, VSAO:0000130] +xref: AAO:0010769 +xref: TAO:0001590 +xref: VSAO:0000130 +xref: Wikipedia:Dermal_bone +xref: XAO:0004015 +xref: ZFA:0001590 is_a: UBERON:0004756 ! dermal skeletal element is_a: UBERON:0007842 ! membrane bone intersection_of: UBERON:0001474 ! bone element @@ -41488,6 +63543,11 @@ relationship: BFO:0000050 UBERON:0010364 ! part of dermal skeleton [Term] id: UBERON:0008909 name: perichordal bone +def: "Bone element that is adjacent to the notochord." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000307] +xref: AAO:0010777 +xref: TAO:0001639 +xref: VSAO:0000307 +xref: ZFA:0001629 is_a: UBERON:0012075 ! replacement bone intersection_of: UBERON:0001474 ! bone element intersection_of: RO:0002220 UBERON:0002328 ! adjacent to notochord @@ -41496,6 +63556,11 @@ relationship: RO:0002220 UBERON:0002328 ! adjacent to notochord [Term] id: UBERON:0008946 name: lung parenchyma +def: "A parenchyma that is part of a lung." [OBOL:automatic] +xref: EMAPA:35522 +xref: FMA:27360 +xref: MA:0003168 +xref: SCTID:201712001 is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000353 ! parenchyma @@ -41505,6 +63570,8 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: UBERON:0008947 name: respiratory primordium +xref: EHDAA2:0004069 +xref: NCIT:C34283 is_a: UBERON:0001048 ! primordium relationship: BFO:0000050 UBERON:0003258 ! part of endoderm of foregut relationship: RO:0002387 UBERON:0001004 ! respiratory system @@ -41512,14 +63579,44 @@ relationship: RO:0002387 UBERON:0001004 ! respiratory system [Term] id: UBERON:0008951 name: left lung lobe +def: "A lobe of lung that is part of a left lung." [OBOL:automatic] +xref: EHDAA:2981 +xref: NCIT:C48945 +xref: SCTID:272655003 is_a: UBERON:0000101 ! lobe of lung intersection_of: UBERON:0000101 ! lobe of lung intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung relationship: BFO:0000050 UBERON:0002168 ! part of left lung +[Term] +id: UBERON:0008989 +name: submucosal esophageal gland +def: "One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed." [BTO:0003634, Wikipedia:Esophageal_glands] +xref: BTO:0003634 +xref: FMA:9404 +xref: NCIT:C32536 +xref: SCTID:322749003 +xref: Wikipedia:Esophageal_glands +is_a: UBERON:0003408 ! gland of digestive tract +is_a: UBERON:0005178 ! thoracic cavity element +is_a: UBERON:0011148 ! submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus +relationship: BFO:0000050 UBERON:0001043 ! part of esophagus +relationship: RO:0001025 UBERON:0001972 ! submucosa of esophagus + [Term] id: UBERON:0008998 name: vasculature of brain +def: "System pertaining to blood vessels in the brain." [BTO:0003840] +xref: BTO:0003840 +xref: EFO:0003491 +xref: EMAPA:35186 +xref: FMA:242007 +xref: FMA:61935 +xref: SCTID:362029003 +xref: TAO:0000099 +xref: ZFA:0000099 is_a: UBERON:0006876 ! vasculature of organ is_a: UBERON:0036303 ! vasculature of central nervous system relationship: BFO:0000050 UBERON:0000955 ! part of brain @@ -41527,6 +63624,9 @@ relationship: BFO:0000050 UBERON:0000955 ! part of brain [Term] id: UBERON:0009015 name: upper back skin +def: "A zone of skin that is part of a dorsal thoracic segment of trunk." [OBOL:automatic] +xref: MA:0000510 +xref: SCTID:304890003 is_a: UBERON:0001068 ! skin of back is_a: UBERON:0001418 ! skin of thorax intersection_of: UBERON:0000014 ! zone of skin @@ -41536,6 +63636,10 @@ relationship: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of tr [Term] id: UBERON:0009030 name: left pulmonary vein +def: "Vein that drains left lung and returns blood to the heart." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0002207 +xref: NCIT:C48946 +xref: SCTID:304057004 is_a: UBERON:0002016 ! pulmonary vein intersection_of: UBERON:0002016 ! pulmonary vein intersection_of: RO:0002179 UBERON:0002168 ! left lung @@ -41544,6 +63648,10 @@ relationship: RO:0002179 UBERON:0002168 ! left lung [Term] id: UBERON:0009032 name: right pulmonary vein +def: "Vein that drains right lung and returns blood to the heart." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0002208 +xref: NCIT:C48947 +xref: SCTID:304056008 is_a: UBERON:0002016 ! pulmonary vein intersection_of: UBERON:0002016 ! pulmonary vein intersection_of: RO:0002179 UBERON:0002167 ! right lung @@ -41552,22 +63660,35 @@ relationship: RO:0002179 UBERON:0002167 ! right lung [Term] id: UBERON:0009117 name: indifferent gonad +def: "A gonad prior to differentiating into a definitive testis or ovary." [http://www.medterms.com/script/main/art.asp?articlekey=8981] +comment: typically part of the embryo - however, in male tammar wallabies the gonads are indifferent at the neonatal stage[8827321] +xref: EHDAA2:0000716 +xref: NCIT:C34192 is_a: UBERON:0000991 ! gonad relationship: BFO:0000050 UBERON:0009196 ! part of indifferent external genitalia [Term] id: UBERON:0009127 name: epibranchial ganglion +def: "Cranial ganglion which develops from an epibranchial placode." [PMID:20133851, ZFIN:curator] +comment: Epibranchial ganglia orchestrate the development of the cranial neurogenic crest +xref: TAO:0001555 +xref: ZFA:0001555 is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: RO:0002202 UBERON:0003078 ! epibranchial placode relationship: RO:0002202 UBERON:0003078 ! epibranchial placode -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009129 name: right atrium endocardium +def: "Endocardium that is part of the right atrium." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0000274 +xref: FMA:7281 +xref: NCIT:C102339 +xref: SCTID:3194006 +xref: VHOG:0001228 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0002166 ! endocardium of atrium is_a: UBERON:0005291 ! embryonic tissue @@ -41581,6 +63702,13 @@ relationship: RO:0002202 UBERON:0005092 ! right horn of sinus venosus [Term] id: UBERON:0009133 name: pleuroperitoneal membrane +def: "A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities." [http://medical-dictionary.thefreedictionary.com/pleuroperitoneal+membrane, Wikipedia:Pleuroperitoneal] +xref: EHDAA2:0001483 +xref: EMAPA:17709 +xref: NCIT:C34256 +xref: SCTID:361429005 +xref: VHOG:0000757 +xref: Wikipedia:Pleuroperitoneal is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue relationship: RO:0002220 UBERON:0001179 ! adjacent to peritoneal cavity @@ -41589,6 +63717,9 @@ relationship: RO:0002220 UBERON:0002402 ! adjacent to pleural cavity [Term] id: UBERON:0009141 name: craniocervical region vein +def: "A vein that is part of a craniocervical region." [OBOL:automatic] +xref: EHDAA2:0004542 +xref: SCTID:32945007 is_a: UBERON:0013140 ! systemic vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region @@ -41597,6 +63728,10 @@ relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region [Term] id: UBERON:0009142 name: entire embryonic mesenchyme +def: "Sum total of mesenchyme in the embryo." [https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/7] +xref: EHDAA2:0001113 +xref: EHDAA:177 +xref: EMAPA:16097 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: RO:0002254 UBERON:0000926 ! mesoderm @@ -41605,18 +63740,76 @@ relationship: RO:0002473 UBERON:0003104 ! mesenchyme [Term] id: UBERON:0009145 name: pharyngeal region of foregut +xref: EMAPA:16549 +xref: RETIRED_EHDAA2:0001454 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0001041 ! part of foregut +[Term] +id: UBERON:0009191 +name: sphenoid bone pre-cartilage condensation +def: "A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] +xref: EHDAA2:0003446 +xref: EMAPA:18015 +is_a: UBERON:0000481 ! multi-tissue structure +is_a: UBERON:0005866 ! pre-cartilage condensation +is_a: UBERON:0009891 ! facial mesenchyme +is_a: UBERON:0014387 ! mesenchyme derived from neural crest +is_a: UBERON:0015060 ! sphenoid endochondral element +intersection_of: UBERON:0015060 ! sphenoid endochondral element +intersection_of: RO:0002473 UBERON:0005866 ! pre-cartilage condensation +relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium +relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium +relationship: RO:0002473 UBERON:0005866 ! pre-cartilage condensation + +[Term] +id: UBERON:0009193 +name: sphenoid cartilage element +def: "A sphenoid endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] +xref: EHDAA2:0001888 +is_a: UBERON:0003932 ! cartilage element of chondrocranium +is_a: UBERON:0005863 ! cartilaginous condensation +is_a: UBERON:0009891 ! facial mesenchyme +is_a: UBERON:0014387 ! mesenchyme derived from neural crest +is_a: UBERON:0015060 ! sphenoid endochondral element +intersection_of: UBERON:0015060 ! sphenoid endochondral element +intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue +relationship: RO:0002202 UBERON:0009191 ! sphenoid bone pre-cartilage condensation + [Term] id: UBERON:0009196 name: indifferent external genitalia +xref: EHDAA2:0004021 is_a: UBERON:0004176 ! external genitalia relationship: BFO:0000050 UBERON:0000922 ! part of embryo +[Term] +id: UBERON:0009204 +name: medial nasal process mesenchyme +def: "Mesenchyme that is part of a medial nasal prominence." [OBOL:automatic] +xref: EHDAA2:0001077 +xref: EMAPA:16810 +xref: FMA:312659 +is_a: UBERON:0009501 ! mesenchyme of fronto-nasal process +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0004068 ! part of medial nasal prominence +relationship: BFO:0000050 UBERON:0004068 ! part of medial nasal prominence + +[Term] +id: UBERON:0009292 +name: embryonic nasal process +xref: EHDAA2:0000581 +xref: EHDAA:4776 +xref: EMAPA:16680 +xref: SCTID:308881001 +is_a: UBERON:0012314 ! embryonic facial prominence + [Term] id: UBERON:0009479 name: ectoderm of buccopharyngeal membrane +def: "An ectoderm that is part of a buccopharyngeal membrane." [OBOL:automatic] +xref: EHDAA2:0000190 +xref: EMAPA:16260 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane @@ -41625,14 +63818,43 @@ relationship: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane [Term] id: UBERON:0009480 name: endoderm of buccopharyngeal membrane +def: "An endoderm that is part of a buccopharyngeal membrane." [OBOL:automatic] +xref: EHDAA2:0000191 +xref: EMAPA:16261 is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane relationship: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane +[Term] +id: UBERON:0009482 +name: associated mesenchyme of foregut-midgut junction +def: "Mesenchyme that is part of a foregut-midgut junction." [OBOL:automatic] +xref: EHDAA2:0000570 +xref: EMAPA:16364 +is_a: UBERON:0003104 ! mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction + +[Term] +id: UBERON:0009483 +name: mesentery of foregut-midgut junction +def: "A mesentery that is part of a foregut-midgut junction." [OBOL:automatic] +xref: EHDAA2:0000575 +xref: EMAPA:16365 +xref: VHOG:0000430 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction + [Term] id: UBERON:0009494 name: pharyngeal arch mesenchymal region +def: "A portion of mesenchymal tissue associated with an individual pharyngeal arch." [https://orcid.org/0000-0002-6601-2165] +xref: EMAPA:32755 +xref: FMA:295694 is_a: UBERON:0005253 ! head mesenchyme is_a: UBERON:0007524 ! dense mesenchyme tissue intersection_of: UBERON:0003104 ! mesenchyme @@ -41641,9 +63863,51 @@ relationship: BFO:0000050 UBERON:0002539 ! part of pharyngeal arch relationship: BFO:0000050 UBERON:0010046 ! part of entire pharyngeal arch associated mesenchyme relationship: RO:0002254 UBERON:0003099 ! cranial neural crest +[Term] +id: UBERON:0009497 +name: epithelium of foregut-midgut junction +def: "An epithelium that is part of a foregut-midgut junction." [OBOL:automatic] +xref: EHDAA2:0000573 +xref: EMAPA:16564 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0003929 ! digestive tract epithelium +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: BFO:0000050 UBERON:0003929 ! part of digestive tract epithelium +relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: RO:0002202 UBERON:0009550 ! endoderm of foregut-midgut junction + +[Term] +id: UBERON:0009501 +name: mesenchyme of fronto-nasal process +def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head." [MP:0011266] +xref: EHDAA2:0004109 +xref: EMAPA:16683 +xref: FMA:295821 +is_a: UBERON:0007213 ! mesenchyme derived from head neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence +relationship: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence +relationship: RO:0002202 UBERON:0007213 ! mesenchyme derived from head neural crest + +[Term] +id: UBERON:0009503 +name: mesenchyme of hindgut +def: "Mesenchyme that is part of a developing hindgut." [OBOL:automatic] +xref: EHDAA2:0000780 +xref: EMAPA:16716 +is_a: UBERON:0003104 ! mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut +relationship: BFO:0000050 UBERON:0001046 ! part of hindgut + [Term] id: UBERON:0009505 name: mesenchyme of trachea +def: "Mesenchyme that is part of a developing trachea." [OBOL:automatic] +xref: EHDAA2:0002067 +xref: EMAPA:16854 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0007524 ! dense mesenchyme tissue intersection_of: UBERON:0003104 ! mesenchyme @@ -41651,15 +63915,108 @@ intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 UBERON:0002539 ! pharyngeal arch +[Term] +id: UBERON:0009521 +name: anal membrane endodermal component +def: "An endoderm that is part of a anal region." [OBOL:automatic] +xref: EHDAA2:0004020 +xref: EMAPA:17177 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000490 ! unilaminar epithelium +intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region +intersection_of: RO:0002202 UBERON:0000925 ! endoderm +relationship: BFO:0000050 UBERON:0001353 ! part of anal region + +[Term] +id: UBERON:0009526 +name: maxillary process mesenchyme +def: "Mesenchyme that is part of a maxillary prominence." [OBOL:automatic] +xref: EHDAA2:0001071 +xref: EMAPA:17361 +xref: FMA:312691 +is_a: UBERON:0003104 ! mesenchyme +is_a: UBERON:0005291 ! embryonic tissue +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0005868 ! part of maxillary prominence +relationship: BFO:0000050 UBERON:0005868 ! part of maxillary prominence + +[Term] +id: UBERON:0009548 +name: hepatic sinusoid of left of lobe of liver +def: "A hepatic sinusoid that is part of a left lobe of liver." [OBOL:automatic] +xref: EHDAA2:0001001 +xref: EMAPA:18309 +xref: VHOG:0000709 +is_a: UBERON:0001281 ! hepatic sinusoid +intersection_of: UBERON:0001281 ! hepatic sinusoid +intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: RO:0002226 UBERON:0001115 ! left lobe of liver + +[Term] +id: UBERON:0009549 +name: hepatic sinusoid of right of lobe of liver +def: "A hepatic sinusoid that is part of a right lobe of liver." [OBOL:automatic] +xref: EHDAA2:0001009 +xref: EMAPA:18316 +xref: VHOG:0000710 +is_a: UBERON:0001281 ! hepatic sinusoid +intersection_of: UBERON:0001281 ! hepatic sinusoid +intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: RO:0002226 UBERON:0001114 ! right lobe of liver + +[Term] +id: UBERON:0009550 +name: endoderm of foregut-midgut junction +def: "An endoderm that is part of a foregut-midgut junction." [OBOL:automatic] +xref: EHDAA2:0000572 +xref: EMAPA:18403 +is_a: UBERON:0000925 ! endoderm +intersection_of: UBERON:0000925 ! endoderm +intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction + +[Term] +id: UBERON:0009566 +name: intestinal submucosa +def: "A submucosa that is part of a intestine." [OBOL:automatic] +xref: FMA:15696 +is_a: UBERON:0018257 ! submucosa of digestive tract +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine + +[Term] +id: UBERON:0009568 +name: trunk region of vertebral column +def: "Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions." [UBERONREF:0000006] +xref: FMA:72066 +xref: NCIT:C92597 +xref: SCTID:281699004 +is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk +intersection_of: subdivision_of UBERON:0002100 ! trunk +relationship: BFO:0000050 UBERON:0002100 ! part of trunk +relationship: subdivision_of UBERON:0002100 ! trunk + [Term] id: UBERON:0009569 name: subdivision of trunk +xref: FMA:25054 +xref: SCTID:22943007 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0009570 name: spinal cord sulcus limitans +def: "A sulcus limitans of neural tube that is part of a future spinal cord." [OBOL:automatic] +xref: EHDAA2:0001265 +xref: EMAPA:17584 +xref: VHOG:0001548 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord @@ -41668,6 +64025,9 @@ relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord [Term] id: UBERON:0009576 name: medulla oblongata sulcus limitans +def: "A sulcus limitans of neural tube that is part of a future medulla oblongata." [OBOL:automatic] +xref: EHDAA2:0001100 +xref: EMAPA:17561 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0001896 ! part of medulla oblongata @@ -41677,6 +64037,9 @@ relationship: RO:0002202 UBERON:0009578 ! myelencephalon sulcus limitans [Term] id: UBERON:0009577 name: metencephalon sulcus limitans +def: "A sulcus limitans of neural tube that is part of a future metencephalon." [OBOL:automatic] +xref: EHDAA2:0001161 +xref: EMAPA:17567 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0010092 ! part of future metencephalon @@ -41685,6 +64048,8 @@ relationship: BFO:0000050 UBERON:0010092 ! part of future metencephalon [Term] id: UBERON:0009578 name: myelencephalon sulcus limitans +def: "A sulcus limitans of neural tube that is part of a future myelencephalon." [OBOL:automatic] +xref: EHDAA2:0001945 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0010096 ! part of future myelencephalon @@ -41693,6 +64058,9 @@ relationship: BFO:0000050 UBERON:0010096 ! part of future myelencephalon [Term] id: UBERON:0009581 name: midbrain mantle layer +xref: EHDAA2:0001172 +xref: EMAPA:16977 +xref: VHOG:0000910 is_a: UBERON:0004061 ! neural tube mantle layer intersection_of: UBERON:0004061 ! neural tube mantle layer intersection_of: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain @@ -41701,6 +64069,8 @@ relationship: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain [Term] id: UBERON:0009583 name: spinal cord mantle layer +xref: EMAPA:17580 +xref: VHOG:0000911 is_a: UBERON:0004061 ! neural tube mantle layer intersection_of: UBERON:0004061 ! neural tube mantle layer intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord @@ -41709,6 +64079,9 @@ relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord [Term] id: UBERON:0009584 name: 1st arch mandibular mesenchyme +def: "Mesenchyme that is part of a 1st arch mandibular component." [OBOL:automatic] +xref: EHDAA2:0000034 +xref: EMAPA:16385 is_a: UBERON:0010042 ! 1st arch mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0007237 ! part of 1st arch mandibular component @@ -41717,6 +64090,10 @@ relationship: BFO:0000050 UBERON:0007237 ! part of 1st arch mandibular component [Term] id: UBERON:0009602 name: left lung associated mesenchyme +def: "Mesenchyme that is part of a developing left lung." [OBOL:automatic] +xref: EHDAA2:0000944 +xref: EMAPA:16730 +xref: EMAPA:17654 is_a: UBERON:0004883 ! lung mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung @@ -41725,6 +64102,9 @@ relationship: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0009603 name: right lung associated mesenchyme +def: "Mesenchyme that is part of a developing right lung." [OBOL:automatic] +xref: EHDAA2:0001739 +xref: EMAPA:17662 is_a: UBERON:0004883 ! lung mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -41733,6 +64113,9 @@ relationship: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0009611 name: midbrain neural plate +def: "A neural plate that develops_from a presumptive midbrain." [OBOL:automatic] +xref: TAO:0007019 +xref: ZFA:0007019 is_a: UBERON:0003075 ! neural plate relationship: BFO:0000050 UBERON:0003056 ! part of pre-chordal neural plate relationship: RO:0002202 UBERON:0009616 ! presumptive midbrain @@ -41740,6 +64123,9 @@ relationship: RO:0002202 UBERON:0009616 ! presumptive midbrain [Term] id: UBERON:0009614 name: hindbrain neural plate +def: "A neural plate that develops_from a presumptive hindbrain." [OBOL:automatic] +xref: TAO:0007022 +xref: ZFA:0007022 is_a: UBERON:0003075 ! neural plate relationship: BFO:0000050 UBERON:0003057 ! part of chordal neural plate relationship: RO:0002202 UBERON:0007277 ! presumptive hindbrain @@ -41747,6 +64133,8 @@ relationship: RO:0002202 UBERON:0007277 ! presumptive hindbrain [Term] id: UBERON:0009615 name: midbrain hindbrain boundary neural plate +xref: TAO:0007044 +xref: ZFA:0007044 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0003075 ! part of neural plate relationship: RO:0002495 UBERON:0007281 ! presumptive midbrain hindbrain boundary @@ -41754,6 +64142,14 @@ relationship: RO:0002495 UBERON:0007281 ! presumptive midbrain hindbrain boundar [Term] id: UBERON:0009616 name: presumptive midbrain +def: "A presumptive structure that has the potential to develop into a midbrain." [OBOL:automatic] +xref: BAMS:MES +xref: EFO:0003432 +xref: EHDAA2:0000615 +xref: EMAPA:16140 +xref: TAO:0000148 +xref: Wikipedia:Mesencephalon +xref: ZFA:0000148 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001891 ! midbrain @@ -41765,6 +64161,10 @@ relationship: RO:0002387 UBERON:0001891 ! midbrain [Term] id: UBERON:0009617 name: head paraxial mesoderm +def: "Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles." [PMID:21610022] +xref: EHDAA2:0000736 +xref: EHDAA:364 +xref: EMAPA:16171 is_a: UBERON:0005253 ! head mesenchyme relationship: BFO:0000050 UBERON:0003077 ! part of paraxial mesoderm relationship: BFO:0000050 UBERON:0005253 ! part of head mesenchyme @@ -41772,19 +64172,36 @@ relationship: BFO:0000050 UBERON:0005253 ! part of head mesenchyme [Term] id: UBERON:0009618 name: trunk paraxial mesoderm +xref: EHDAA2:0002094 is_a: UBERON:0005256 ! trunk mesenchyme relationship: BFO:0000050 UBERON:0003077 ! part of paraxial mesoderm relationship: BFO:0000050 UBERON:0005256 ! part of trunk mesenchyme +[Term] +id: UBERON:0009621 +name: tail somite +def: "A somite that is part of a tail." [OBOL:automatic] +xref: AAO:0010383 +xref: EMAPA:16860 +xref: XAO:0003143 +is_a: UBERON:0002329 ! somite +intersection_of: UBERON:0002329 ! somite +intersection_of: BFO:0000050 UBERON:0002415 ! part of tail +relationship: BFO:0000050 UBERON:0002415 ! part of tail + [Term] id: UBERON:0009644 name: trachea non-cartilage connective tissue +xref: EMAPA:35878 +xref: MA:0001859 is_a: UBERON:0003571 ! trachea connective tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009652 name: bronchus basement membrane +def: "A basement membrane that is part of a bronchus." [OBOL:automatic] +xref: MA:0001832 +xref: NCIT:C49208 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0015329 ! respiratory system basement membrane intersection_of: UBERON:0005769 ! basement membrane of epithelium @@ -41794,6 +64211,9 @@ relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus [Term] id: UBERON:0009653 name: trachea basement membrane +def: "A basement membrane that is part of a trachea." [OBOL:automatic] +xref: MA:0001854 +xref: NCIT:C49302 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0015329 ! respiratory system basement membrane intersection_of: UBERON:0005769 ! basement membrane of epithelium @@ -41804,6 +64224,8 @@ relationship: BFO:0000050 UBERON:0009644 ! part of trachea non-cartilage connect [Term] id: UBERON:0009657 name: artery of lip +xref: MA:0001987 +xref: NCIT:C52947 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0001833 ! lip @@ -41812,6 +64234,10 @@ relationship: RO:0002178 UBERON:0001833 ! lip [Term] id: UBERON:0009661 name: midbrain nucleus +def: "Nucleus located in the midbrain." [ZFIN:curator] +xref: SCTID:279285003 +xref: TAO:0002209 +xref: ZFA:0001665 is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain @@ -41820,14 +64246,83 @@ relationship: BFO:0000050 UBERON:0001891 ! part of midbrain [Term] id: UBERON:0009662 name: hindbrain nucleus +def: "Nucleus located within the hindbrain." [ZFIN:curator] +xref: TAO:0002177 +xref: ZFA:0001658 is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain +[Term] +id: UBERON:0009664 +name: gut mesentery +xref: EHDAA2:0004566 +xref: EMAPA:32911 +xref: MA:0003203 +is_a: UBERON:0002095 ! mesentery +relationship: RO:0001025 UBERON:0001179 ! peritoneal cavity + +[Term] +id: UBERON:0009669 +name: embryonic cloacal lumen +def: "An anatomical space that surrounded_by a embryonic cloaca." [OBOL:automatic] +xref: EHDAA2:0004586 +is_a: UBERON:0012463 ! cloacal lumen +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0000163 ! embryonic cloaca +relationship: BFO:0000050 UBERON:0000163 ! part of embryonic cloaca +relationship: RO:0002219 UBERON:0009846 ! embryonic cloacal epithelium +relationship: RO:0002572 UBERON:0000163 ! embryonic cloaca + +[Term] +id: UBERON:0009670 +name: rectal lumen +def: "An anatomical space that surrounded_by a rectum." [OBOL:automatic] +xref: EHDAA2:0004587 +xref: EMAPA:18388 +xref: FMA:14598 +xref: SCTID:259740004 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0001052 ! rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0012465 ! part of lumen of terminal part of digestive tract +relationship: RO:0002202 UBERON:0009669 ! embryonic cloacal lumen +relationship: RO:0002572 UBERON:0001052 ! rectum + +[Term] +id: UBERON:0009708 +name: dorsal pancreas +xref: EHDAA2:0001371 +is_a: UBERON:0002365 ! exocrine gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005177 ! trunk region element +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: RO:0002202 UBERON:0010375 ! pancreas dorsal primordium +relationship: RO:0002254 UBERON:0003923 ! dorsal pancreatic bud + +[Term] +id: UBERON:0009709 +name: ventral pancreas +xref: EHDAA2:0001393 +is_a: UBERON:0002365 ! exocrine gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005177 ! trunk region element +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: RO:0002202 UBERON:0010376 ! pancreas ventral primordium +relationship: RO:0002254 UBERON:0003924 ! ventral pancreatic bud + [Term] id: UBERON:0009712 name: endocardium of right ventricle +def: "Any endocardium that is part of the right ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0002188 +xref: EMAPA:17341 +xref: FMA:9536 +xref: NCIT:C102343 +xref: SCTID:8911002 +xref: VHOG:0001235 is_a: UBERON:0001081 ! endocardium of ventricle intersection_of: UBERON:0001081 ! endocardium of ventricle intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle @@ -41838,6 +64333,12 @@ relationship: RO:0002371 UBERON:0006567 ! right ventricle myocardium [Term] id: UBERON:0009713 name: endocardium of left ventricle +def: "Any endocardium that is part of the left ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0002182 +xref: EMAPA:17338 +xref: FMA:9559 +xref: SCTID:191004004 +xref: VHOG:0001233 is_a: UBERON:0001081 ! endocardium of ventricle intersection_of: UBERON:0001081 ! endocardium of ventricle intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle @@ -41847,6 +64348,7 @@ relationship: RO:0002371 UBERON:0006566 ! left ventricle myocardium [Term] id: UBERON:0009715 name: stomodeal lumen +def: "An anatomical cavity that surrounded_by a stomodeum." [OBOL:automatic] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000930 ! stomodeum @@ -41855,6 +64357,9 @@ relationship: RO:0002572 UBERON:0000930 ! stomodeum [Term] id: UBERON:0009722 name: entire pharyngeal arch endoderm +xref: EHDAA2:0004621 +xref: EMAPA:32754 +xref: FMA:293087 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0015833 ! foregut epithelium @@ -41864,15 +64369,31 @@ relationship: BFO:0000050 UBERON:0008814 ! part of pharyngeal arch system [Term] id: UBERON:0009751 name: cardiac mesenchyme +def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures." [MP:0011264] +xref: EHDAA2:0004162 +xref: EMAPA:36438 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart +[Term] +id: UBERON:0009752 +name: pancreas mesenchyme +def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas." [MP:0011265] +xref: EFO:0002557 +xref: EMAPA:26220 +is_a: UBERON:0003104 ! mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: UBERON:0009758 name: abdominal ganglion +def: "A ganglion that is part of a abdominal segment of trunk." [OBOL:automatic] +xref: SCTID:280508003 is_a: UBERON:0007134 ! trunk ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -41881,6 +64402,10 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0009778 name: pleural sac +def: "A serous sac that has the pleura and the pleural cavity as parts." [https://github.com/obophenotype/uberon/issues/86] +xref: EHDAA2:0004737 +xref: FMA:9690 +xref: SCTID:361996004 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005906 ! serous sac is_a: UBERON:0015212 ! lateral structure @@ -41895,6 +64420,9 @@ relationship: BSPO:0000126 UBERON:0001004 ! respiratory system [Term] id: UBERON:0009842 name: glandular acinus +def: "The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form." [Wikipedia:Acinus] +xref: FMA:55588 +xref: Wikipedia:Acinus is_a: UBERON:0034922 ! cell cluster intersection_of: UBERON:0034922 ! cell cluster intersection_of: BFO:0000050 UBERON:0002530 ! part of gland @@ -41904,9 +64432,24 @@ relationship: BFO:0000050 UBERON:0002530 ! part of gland relationship: BFO:0000051 CL:0000151 ! has part secretory cell relationship: RO:0000086 PATO:0002422 +[Term] +id: UBERON:0009846 +name: embryonic cloacal epithelium +def: "An epithelium that is part of a embryonic cloaca." [OBOL:automatic] +xref: EHDAA2:0004585 +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0009521 ! anal membrane endodermal component +is_a: UBERON:0012481 ! cloacal epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000163 ! part of embryonic cloaca +relationship: BFO:0000050 UBERON:0000163 ! part of embryonic cloaca +relationship: BFO:0000050 UBERON:0003929 ! part of digestive tract epithelium +relationship: RO:0002202 UBERON:0003353 ! epithelium of hindgut + [Term] id: UBERON:0009854 name: digestive tract diverticulum +def: "Branch or outpocketing of the digestive tract." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0009856 ! sac intersection_of: UBERON:0009856 ! sac @@ -41915,6 +64458,7 @@ intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: UBERON:0009856 name: sac +xref: galen:Diverticulum is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0000086 PATO:0001987 @@ -41923,6 +64467,12 @@ relationship: RO:0000086 PATO:0001987 [Term] id: UBERON:0009870 name: zone of stomach +def: "A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland." [ISBN:0073040584, Wikipedia:Stomach#Sections] +xref: EMAPA:35821 +xref: FMA:14558 +xref: MA:0002561 +xref: SCTID:245415005 +xref: Wikipedia:Stomach#Sections is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0034944 ! zone of organ intersection_of: UBERON:0034944 ! zone of organ @@ -41932,6 +64482,9 @@ relationship: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: UBERON:0009881 name: anterior lateral plate mesoderm +xref: EFO:0003704 +xref: TAO:0005041 +xref: ZFA:0005041 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm @@ -41939,6 +64492,8 @@ relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm [Term] id: UBERON:0009889 name: secondary heart field +def: "A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." [GO:0003139, GOC:mtg_heart, GOC:rl] +xref: XAO:0004186 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -41951,6 +64506,9 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0009891 name: facial mesenchyme +def: "Mesenchyme that is part of a developing face." [OBOL:automatic] +xref: EMAPA:35337 +xref: FMA:302884 is_a: UBERON:0005253 ! head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001456 ! part of face @@ -41959,16 +64517,24 @@ relationship: BFO:0000050 UBERON:0001456 ! part of face [Term] id: UBERON:0009911 name: lobule +xref: FMA:45737 +xref: NCIT:C12990 is_a: UBERON:0000063 ! organ subunit [Term] id: UBERON:0009912 name: anatomical lobe +def: "A portion of an organ, such as the liver, lung, breast, or brain." [ncithesaurus:Lobe] +xref: FMA:45728 +xref: NCIT:C13393 +xref: UMLS:C0796494 is_a: UBERON:0000063 ! organ subunit [Term] id: UBERON:0009920 name: optic neural crest +xref: EHDAA2:0001315 +xref: EHDAA:1122 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0007530 ! migrating mesenchyme population relationship: BFO:0000050 UBERON:0007213 ! part of mesenchyme derived from head neural crest @@ -41976,6 +64542,8 @@ relationship: BFO:0000050 UBERON:0007213 ! part of mesenchyme derived from head [Term] id: UBERON:0009953 name: post-embryonic organism +def: "A multicellular organism that existence_starts_with a post-embryonic stage." [OBOL:automatic] +xref: MA:0002405 is_a: UBERON:0000468 ! multicellular organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002489 UBERON:0000092 ! post-embryonic stage @@ -41984,6 +64552,12 @@ relationship: RO:0002489 UBERON:0000092 ! post-embryonic stage [Term] id: UBERON:0009955 name: neurogenic placode +def: "Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia." [http://orcid.org/0000-0002-6601-2165, PMID:11523831] +xref: EFO:0003460 +xref: TAO:0001309 +xref: Wikipedia:Neurogenic_placodes +xref: XAO:0004620 +xref: ZFA:0001309 is_a: UBERON:0002546 ! cranial placode intersection_of: UBERON:0005085 ! ectodermal placode intersection_of: RO:0002385 CL:0000540 ! neuron @@ -41995,21 +64569,35 @@ relationship: RO:0002385 CL:0000540 ! neuron relationship: RO:0002385 UBERON:0001714 ! cranial ganglion relationship: RO:0002385 UBERON:0001785 ! cranial nerve +[Term] +id: UBERON:0009970 +name: epithelium of pancreatic duct +def: "An epithelium that is part of a pancreatic duct." [OBOL:automatic] +xref: EFO:0002556 +xref: FMA:67681 +is_a: UBERON:0010371 ! ecto-epithelium +is_a: UBERON:0013697 ! exocrine pancreas epithelium +is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0007329 ! part of pancreatic duct +relationship: BFO:0000050 UBERON:0007329 ! part of pancreatic duct + [Term] id: UBERON:0010000 name: multicellular anatomical structure +def: "An anatomical structure that has more than one cell as a part." [CARO:0010000] +xref: CARO:0010000 is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0000086 PATO:0001993 relationship: BFO:0000051 CL:0000000 ! has part cell relationship: RO:0000086 PATO:0001993 -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0010009 name: aggregate regional part of brain +def: "A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]." [NLXANAT:20090509] +xref: NLXANAT:20090509 is_a: UBERON:0034923 ! disconnected anatomical group intersection_of: UBERON:0034923 ! disconnected anatomical group intersection_of: BFO:0000050 UBERON:0000955 ! part of brain @@ -42020,6 +64608,10 @@ relationship: RO:0002351 UBERON:0002616 ! regional part of brain [Term] id: UBERON:0010031 name: 6th arch mesenchyme +def: "Mesenchyme that is part of a pharyngeal arch 6." [OBOL:automatic] +xref: EHDAA2:0004076 +xref: EMAPA:32765 +xref: FMA:318209 is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 @@ -42028,6 +64620,10 @@ relationship: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 [Term] id: UBERON:0010039 name: food storage organ +def: "An organ of the digestive tract that is capable of retaining and storing food." [https://orcid.org/0000-0002-6601-2165] +xref: BSA:0000123 +xref: TADS:0000172 +xref: TGMA:0001041 is_a: UBERON:0013765 ! digestive system element relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system @@ -42035,14 +64631,31 @@ relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointe [Term] id: UBERON:0010042 name: 1st arch mesenchyme +def: "Mesenchyme that is part of a pharyngeal arch 1." [OBOL:automatic] +xref: EMAPA:16128 is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 relationship: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 +[Term] +id: UBERON:0010045 +name: 1st arch maxillary mesenchyme +def: "Mesenchyme that is part of a 1st arch maxillary component." [OBOL:automatic] +xref: EHDAA2:0000041 +xref: EMAPA:16391 +is_a: UBERON:0010042 ! 1st arch mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0007238 ! part of 1st arch maxillary component +relationship: BFO:0000050 UBERON:0007238 ! part of 1st arch maxillary component + [Term] id: UBERON:0010046 name: entire pharyngeal arch associated mesenchyme +def: "The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells." [https://orcid.org/0000-0002-6601-2165, XAO:0004524] +xref: EHDAA2:0001459 +xref: EMAPA:16550 +xref: XAO:0004524 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue relationship: BFO:0000050 UBERON:0008814 ! part of pharyngeal arch system @@ -42051,6 +64664,12 @@ relationship: RO:0002254 UBERON:0003099 ! cranial neural crest [Term] id: UBERON:0010047 name: oral gland +def: "Gland of the epithelium lining the oral cavity. The most common are the salivary glands." [ISBN:0073040584] +xref: EHDAA2:0001327 +xref: EHDAA:2181 +xref: EMAPA:16572 +xref: EMAPA:16723 +xref: VHOG:0000652 is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland @@ -42060,11 +64679,30 @@ relationship: BFO:0000050 UBERON:0000165 ! part of mouth [Term] id: UBERON:0010077 name: cuboidal epithelium +def: "An epithelium consisting of cuboidal epithelial cells." [Wikipedia:Cuboidal_epithelium] +xref: NCIT:C32415 +xref: Wikipedia:Cuboidal_epithelium is_a: UBERON:0000483 ! epithelium +[Term] +id: UBERON:0010081 +name: future common hepatic duct +def: "An extrahepatic bile duct that has the potential to develop into a common hepatic duct." [OBOL:automatic] +xref: EHDAA2:0000595 +is_a: UBERON:0003703 ! extrahepatic bile duct +is_a: UBERON:0003914 ! epithelial tube +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0034932 ! epithelium of biliary system +intersection_of: UBERON:0003703 ! extrahepatic bile duct +intersection_of: RO:0002387 UBERON:0001175 ! common hepatic duct +relationship: RO:0002202 UBERON:0005604 ! extrahepatic part of hepatic duct +relationship: RO:0002387 UBERON:0001175 ! common hepatic duct + [Term] id: UBERON:0010083 name: future dermis +def: "Mesenchyme that has the potential to develop into a dermis." [OBOL:automatic] +xref: EHDAA2:0000598 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002387 UBERON:0002067 ! dermis @@ -42076,6 +64714,8 @@ relationship: RO:0002387 UBERON:0002067 ! dermis [Term] id: UBERON:0010084 name: future diaphragm +def: "A structure that will develop into a diaphragm." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0000599 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001103 ! diaphragm @@ -42087,6 +64727,8 @@ relationship: RO:0002387 UBERON:0001103 ! diaphragm [Term] id: UBERON:0010092 name: future metencephalon +def: "A developing anatomical structure that has the potential to develop into a metencephalon." [OBOL:automatic] +xref: EHDAA2:0000623 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001895 ! metencephalon @@ -42096,6 +64738,8 @@ relationship: RO:0002387 UBERON:0001895 ! metencephalon [Term] id: UBERON:0010096 name: future myelencephalon +def: "A developing anatomical structure that has the potential to develop into a myelencephalon." [OBOL:automatic] +xref: EHDAA2:0000640 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0005290 ! myelencephalon @@ -42105,6 +64749,8 @@ relationship: RO:0002387 UBERON:0005290 ! myelencephalon [Term] id: UBERON:0010125 name: future superior salivatory nucleus +def: "A gray matter that has the potential to develop into a superior salivatory nucleus." [OBOL:automatic] +xref: EHDAA2:0004644 is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: RO:0002387 UBERON:0002149 ! superior salivatory nucleus @@ -42113,30 +64759,73 @@ relationship: RO:0002387 UBERON:0002149 ! superior salivatory nucleus [Term] id: UBERON:0010131 name: conducting tissue of heart +def: "Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0004528 +xref: FMA:83378 is_a: UBERON:0001133 ! cardiac muscle tissue [Term] id: UBERON:0010136 name: epithelial sheet +def: "An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GO:0002011] is_a: UBERON:0000483 ! epithelium +[Term] +id: UBERON:0010152 +name: skin mucus +def: "A mucous secretion that is produced by glands in the epidermis." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0000912 ! mucus +intersection_of: UBERON:0000912 ! mucus +intersection_of: RO:0003001 UBERON:0004790 ! produced by skin mucous gland +relationship: RO:0003001 UBERON:0004790 ! produced by skin mucous gland + [Term] id: UBERON:0010161 name: lumen of blood vessel +def: "An anatomical cavity that surrounded_by a blood vessel." [OBOL:automatic] +xref: FMA:312610 +xref: SCTID:91747007 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001981 ! blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: RO:0002572 UBERON:0001981 ! blood vessel +[Term] +id: UBERON:0010162 +name: post-anal tail tip +def: "The distal end of the tail." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0002848 +xref: XAO:0004057 +is_a: UBERON:0011676 ! subdivision of organism along main body axis +intersection_of: UBERON:0011676 ! subdivision of organism along main body axis +intersection_of: BSPO:0001108 UBERON:0007812 ! post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BSPO:0001108 UBERON:0007812 ! post-anal tail + +[Term] +id: UBERON:0010183 +name: liver trabecula +def: "A trabecula that is part of a liver." [GO:0060344, OBOL:automatic] +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000440 ! trabecula +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: UBERON:0010188 name: protuberance +def: "A roughly circular bulge in a surface." [EHDAA2:0003250] +xref: AEO:0000205 +xref: EHDAA2:0003250 +xref: FMA:82506 is_a: UBERON:0034944 ! zone of organ [Term] id: UBERON:0010191 name: aortic system +xref: EHDAA2:0004512 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0004571 ! part of systemic arterial system relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -42144,19 +64833,49 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0010192 name: genital artery +def: "One of the laterally paired arteries that supply the gonads." [ISBN:0073040584, Wikipedia:Gonadal_artery] +xref: Wikipedia:Gonadal_artery is_a: UBERON:0012254 ! abdominal aorta artery intersection_of: UBERON:0004573 ! systemic artery intersection_of: RO:0002178 UBERON:0000991 ! gonad relationship: RO:0002178 UBERON:0000991 ! gonad +[Term] +id: UBERON:0010194 +name: hepatic portal system +def: "A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver." [ISBN:0073040584] +xref: AAO:0010225 +is_a: UBERON:0005806 ! portal system +relationship: RO:0002176 UBERON:0001555 ! digestive tract +relationship: RO:0002176 UBERON:0002107 ! liver + [Term] id: UBERON:0010199 name: bona-fide anatomical boundary +def: "An anatomical boundary that corresponds to some physical discontinuity." [CARO:0001004] +comment: One might argue that all boundaries are actually fiat in the sense that there must be some fiat element at a fine enough scale of granularity. This ontology choses to ignore this issue as below the level of granularity relevant to anatomy. (DOS121102) +xref: CARO:0001004 is_a: UBERON:0000466 ! immaterial anatomical entity +[Term] +id: UBERON:0010204 +name: tail vasculature +def: "A vasculature that is part of a post-anal tail." [OBOL:automatic] +xref: TAO:0005037 +xref: XAO:0004151 +xref: ZFA:0005037 +is_a: UBERON:0002049 ! vasculature +intersection_of: UBERON:0002049 ! vasculature +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:0010227 name: future cardiac atrium +def: "Multi-tissue structure that is part of the heart tube and will become the cardiac atrium." [ZFA:0001718] +xref: FMA:71005 +xref: TAO:0002228 +xref: ZFA:0001718 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0004141 ! part of heart tube relationship: RO:0002387 UBERON:0002081 ! cardiac atrium @@ -42164,6 +64883,12 @@ relationship: RO:0002387 UBERON:0002081 ! cardiac atrium [Term] id: UBERON:0010230 name: eyeball of camera-type eye +def: "The core globe-shaped component of the camera-type eye." [UBERON:cjm] +xref: FMA:12513 +xref: MIAA:0000283 +xref: SCTID:244486005 +xref: VHOG:0001616 +xref: Wikipedia:Globe_(human_eye) is_a: UBERON:0000020 ! sense organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye @@ -42172,6 +64897,10 @@ relationship: RO:0002433 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0010243 name: merocrine gland +def: "An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged." [MGI:anna, MP:0013544, Wikipedia:Merocrine] +xref: BTO:0002324 +xref: MA:0003041 +xref: Wikipedia:Merocrine is_a: UBERON:0002365 ! exocrine gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: RO:0002215 GO:0006887 ! capable of exocytosis @@ -42180,6 +64909,8 @@ relationship: RO:0002215 GO:0006887 ! capable of exocytosis [Term] id: UBERON:0010252 name: 1st arch mandibular mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000037 is_a: UBERON:0009584 ! 1st arch mandibular mesenchyme is_a: UBERON:0010259 ! 1st arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme @@ -42189,9 +64920,26 @@ relationship: BFO:0000050 UBERON:0009584 ! part of 1st arch mandibular mesenchym relationship: BFO:0000050 UBERON:0010258 ! part of mesenchyme from rhombencephalic neural crest relationship: RO:0002202 UBERON:0007098 ! mandibular neural crest +[Term] +id: UBERON:0010253 +name: 1st arch maxillary mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000044 +is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme +is_a: UBERON:0010259 ! 1st arch mesenchyme from neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0010045 ! part of 1st arch maxillary mesenchyme +intersection_of: RO:0002202 UBERON:0002342 ! neural crest +relationship: BFO:0000050 UBERON:0010045 ! part of 1st arch maxillary mesenchyme +relationship: BFO:0000050 UBERON:0010258 ! part of mesenchyme from rhombencephalic neural crest + [Term] id: UBERON:0010256 name: 4th arch mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000098 +xref: EMAPA:16772 +xref: VHOG:0000580 is_a: UBERON:0005691 ! 4th arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest @@ -42204,6 +64952,8 @@ relationship: BFO:0000050 UBERON:0010258 ! part of mesenchyme from rhombencephal [Term] id: UBERON:0010257 name: 6th arch mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004077 is_a: UBERON:0010031 ! 6th arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest @@ -42216,6 +64966,8 @@ relationship: BFO:0000050 UBERON:0010258 ! part of mesenchyme from rhombencephal [Term] id: UBERON:0010258 name: mesenchyme from rhombencephalic neural crest +def: "Mesenchyme that develops_from a rhombencephalon neural crest." [OBOL:automatic] +xref: EHDAA2:0004423 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002202 UBERON:0003852 ! rhombencephalon neural crest @@ -42225,6 +64977,8 @@ relationship: RO:0002202 UBERON:0003852 ! rhombencephalon neural crest [Term] id: UBERON:0010259 name: 1st arch mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme." [OBOL:automatic] +xref: EMAPA:16129 is_a: UBERON:0010042 ! 1st arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest @@ -42233,9 +64987,25 @@ intersection_of: BFO:0000050 UBERON:0010042 ! part of 1st arch mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! neural crest relationship: BFO:0000050 UBERON:0010042 ! part of 1st arch mesenchyme +[Term] +id: UBERON:0010276 +name: space in vertebral column +def: "Any anatomical space that is part of a vertebral column." [OBOL:automatic] +xref: AAO:0000700 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: BFO:0000050 UBERON:0001130 ! part of vertebral column +relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column + [Term] id: UBERON:0010285 name: midbrain basal plate +def: "Portion of tissue that is dorsolateral to the floor plate and part of the midbrain." [ZFA:0000761] +xref: DHBA:12322 +xref: EFO:0003567 +xref: EHDAA2:0004375 +xref: TAO:0000761 +xref: ZFA:0000761 is_a: UBERON:0002020 ! gray matter relationship: BFO:0000050 UBERON:0009581 ! part of midbrain mantle layer relationship: BFO:0000050 UBERON:0010286 ! part of midbrain neural tube @@ -42243,6 +65013,9 @@ relationship: BFO:0000050 UBERON:0010286 ! part of midbrain neural tube [Term] id: UBERON:0010286 name: midbrain neural tube +def: "Portion of neural tube that gives rise to the midbrain." [ZFA:0007039] +xref: TAO:0007039 +xref: ZFA:0007039 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0003080 ! part of anterior neural tube @@ -42250,6 +65023,7 @@ relationship: BFO:0000050 UBERON:0003080 ! part of anterior neural tube [Term] id: UBERON:0010291 name: layer of sclera +xref: Wikipedia:Sclera#Histology is_a: UBERON:0004923 ! organ component layer is_a: UBERON:0010313 ! neural crest-derived structure relationship: BFO:0000050 UBERON:0001773 ! part of sclera @@ -42257,6 +65031,7 @@ relationship: BFO:0000050 UBERON:0001773 ! part of sclera [Term] id: UBERON:0010294 name: scleral endothelium +def: "An endothelium that is part of a sclera." [OBOL:automatic] is_a: UBERON:0001986 ! endothelium is_a: UBERON:0010291 ! layer of sclera is_a: UBERON:0015808 ! eye epithelium @@ -42266,6 +65041,10 @@ intersection_of: BFO:0000050 UBERON:0001773 ! part of sclera [Term] id: UBERON:0010295 name: substantia propria of sclera +def: "A stroma that is part of a sclera." [OBOL:automatic] +xref: FMA:58365 +xref: NCIT:C33652 +xref: SCTID:368851004 is_a: UBERON:0003891 ! stroma is_a: UBERON:0010291 ! layer of sclera intersection_of: UBERON:0003891 ! stroma @@ -42274,6 +65053,7 @@ intersection_of: BFO:0000050 UBERON:0001773 ! part of sclera [Term] id: UBERON:0010299 name: scleral mesenchyme +def: "Mesenchyme surrounding the developing optic cup which develops into the sclera." [https://orcid.org/0000-0002-6601-2165, PMID:16496288] is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002387 UBERON:0001773 ! sclera @@ -42283,6 +65063,7 @@ relationship: RO:0002387 UBERON:0001773 ! sclera [Term] id: UBERON:0010303 name: extraembryonic epithelium +def: "An epithelium that is part of a extraembryonic structure." [OBOL:automatic] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005292 ! extraembryonic tissue intersection_of: UBERON:0000483 ! epithelium @@ -42292,6 +65073,9 @@ relationship: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure [Term] id: UBERON:0010312 name: immature eye +def: "Developing anatomical structure that develops into the eyeball and associated structures." [ZFA:0001678] +xref: TAO:0002201 +xref: ZFA:0001678 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: RO:0002254 UBERON:0003071 ! eye primordium @@ -42301,6 +65085,7 @@ relationship: RO:0002254 UBERON:0003071 ! eye primordium [Term] id: UBERON:0010313 name: neural crest-derived structure +def: "An anatomical structure that develops from the neural crest." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000061 ! anatomical structure @@ -42310,6 +65095,7 @@ relationship: RO:0002202 UBERON:0002342 ! neural crest [Term] id: UBERON:0010314 name: structure with developmental contribution from neural crest +def: "An anatomical structure that has some part that develops from the neural crest." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002254 UBERON:0002342 ! neural crest @@ -42325,6 +65111,7 @@ relationship: RO:0002202 UBERON:0002532 ! epiblast (generic) [Term] id: UBERON:0010321 name: skeletal element of eye region +def: "A skeletal element that is part of a orbital region." [OBOL:automatic] is_a: UBERON:0004765 ! skeletal element is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0004765 ! skeletal element @@ -42335,6 +65122,14 @@ relationship: BFO:0000050 UBERON:0011156 ! part of facial skeleton [Term] id: UBERON:0010323 name: cranial skeletal system +def: "Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000049] +xref: AAO:0000109 +xref: AAO:0000971 +xref: AAO:0010185 +xref: TAO:0000737 +xref: VSAO:0000049 +xref: XAO:0003075 +xref: ZFA:0000737 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0011137 ! part of axial skeletal system relationship: RO:0002160 NCBITaxon:89593 ! Craniata @@ -42342,6 +65137,7 @@ relationship: RO:0002160 NCBITaxon:89593 ! Craniata [Term] id: UBERON:0010329 name: paired limb/fin bud mesenchyme +def: "Mesenchyme that is part of a limb/fin bud." [OBOL:automatic] is_a: UBERON:0010377 ! mesenchyme from somatopleure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004357 ! part of paired limb/fin bud @@ -42351,6 +65147,7 @@ relationship: RO:0002202 UBERON:0010377 ! mesenchyme from somatopleure [Term] id: UBERON:0010333 name: extraembryonic membrane mesenchyme +def: "Mesenchyme that is part of a extraembryonic membrane." [OBOL:automatic] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005292 ! extraembryonic tissue @@ -42359,9 +65156,37 @@ intersection_of: BFO:0000050 UBERON:0005631 ! part of extraembryonic membrane relationship: BFO:0000050 UBERON:0005631 ! part of extraembryonic membrane relationship: RO:0002202 UBERON:0005728 ! extraembryonic mesoderm +[Term] +id: UBERON:0010334 +name: maxillary process mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004601 +is_a: UBERON:0009526 ! maxillary process mesenchyme +is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0009526 ! part of maxillary process mesenchyme +intersection_of: RO:0002202 UBERON:0002342 ! neural crest +relationship: BFO:0000050 UBERON:0009526 ! part of maxillary process mesenchyme +relationship: RO:0002202 UBERON:0010253 ! 1st arch maxillary mesenchyme from neural crest + +[Term] +id: UBERON:0010335 +name: maxillary process mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004602 +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0009526 ! maxillary process mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0009526 ! part of maxillary process mesenchyme +intersection_of: RO:0002202 UBERON:0006904 ! head mesenchyme from mesoderm +relationship: BFO:0000050 UBERON:0009526 ! part of maxillary process mesenchyme +relationship: RO:0002202 UBERON:0010338 ! 1st arch maxillary mesenchyme from head mesenchyme + [Term] id: UBERON:0010336 name: mandibular process mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004603 is_a: UBERON:0006905 ! mandibular process mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest intersection_of: UBERON:0003104 ! mesenchyme @@ -42373,6 +65198,8 @@ relationship: RO:0002202 UBERON:0010252 ! 1st arch mandibular mesenchyme from ne [Term] id: UBERON:0010337 name: mandibular process mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004604 is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0006905 ! mandibular process mesenchyme intersection_of: UBERON:0003104 ! mesenchyme @@ -42381,9 +65208,23 @@ intersection_of: RO:0002202 UBERON:0006904 ! head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0006905 ! part of mandibular process mesenchyme relationship: RO:0002202 UBERON:0010339 ! 1st arch mandibular mesenchyme from head mesenchyme +[Term] +id: UBERON:0010338 +name: 1st arch maxillary mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000043 +is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme +is_a: UBERON:0010341 ! 1st arch mesenchyme from head mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0010045 ! part of 1st arch maxillary mesenchyme +intersection_of: RO:0002202 UBERON:0006904 ! head mesenchyme from mesoderm +relationship: BFO:0000050 UBERON:0010045 ! part of 1st arch maxillary mesenchyme + [Term] id: UBERON:0010339 name: 1st arch mandibular mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000036 is_a: UBERON:0009584 ! 1st arch mandibular mesenchyme is_a: UBERON:0010341 ! 1st arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme @@ -42394,6 +65235,8 @@ relationship: BFO:0000050 UBERON:0009584 ! part of 1st arch mandibular mesenchym [Term] id: UBERON:0010341 name: 1st arch mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme." [OBOL:automatic] +xref: EMAPA:16130 is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0010042 ! 1st arch mesenchyme is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme @@ -42405,6 +65248,9 @@ relationship: BFO:0000050 UBERON:0010042 ! part of 1st arch mesenchyme [Term] id: UBERON:0010345 name: 4th arch mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000097 +xref: EMAPA:16771 is_a: UBERON:0005691 ! 4th arch mesenchyme is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme @@ -42416,6 +65262,8 @@ relationship: BFO:0000050 UBERON:0005691 ! part of 4th arch mesenchyme [Term] id: UBERON:0010347 name: 6th arch mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004078 is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0010031 ! 6th arch mesenchyme is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme @@ -42427,6 +65275,8 @@ relationship: BFO:0000050 UBERON:0010031 ! part of 6th arch mesenchyme [Term] id: UBERON:0010359 name: pharyngeal arch mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme." [OBOL:automatic] +comment: Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0014387 ! mesenchyme derived from neural crest intersection_of: UBERON:0003104 ! mesenchyme @@ -42437,6 +65287,8 @@ relationship: BFO:0000050 UBERON:0010046 ! part of entire pharyngeal arch associ [Term] id: UBERON:0010360 name: pharyngeal arch mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme." [OBOL:automatic] +comment: Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -42449,6 +65301,10 @@ relationship: RO:0002202 UBERON:0006904 ! head mesenchyme from mesoderm [Term] id: UBERON:0010362 name: endoskeleton +def: "Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000037] +xref: VSAO:0000037 +xref: Wikipedia:Endoskeleton +xref: XAO:0004026 is_a: UBERON:0010912 ! subdivision of skeleton relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002473 UBERON:0010522 ! replacement element @@ -42456,17 +65312,28 @@ relationship: RO:0002473 UBERON:0010522 ! replacement element [Term] id: UBERON:0010363 name: endochondral element +def: "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000139] +xref: VSAO:0000139 +xref: XAO:0004017 +xref: ZFA:0005620 is_a: UBERON:0004765 ! skeletal element [Term] id: UBERON:0010364 name: dermal skeleton +def: "Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000035] +comment: This ontology covers metazoa, so we do not use exoskeleton as primary label, as in VSAO +xref: VSAO:0000035 +xref: XAO:0004025 is_a: UBERON:0010912 ! subdivision of skeleton relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0010368 name: pulmonary lobule +def: "The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa." [ncithesaurus:Pulmonary_Lobule] +xref: FMA:75739 +xref: NCIT:C33428 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0009911 ! lobule intersection_of: UBERON:0009911 ! lobule @@ -42476,22 +65343,51 @@ relationship: BFO:0000050 UBERON:8600017 ! part of bronchopulmonary segment [Term] id: UBERON:0010369 name: secondary pulmonary lobule +def: "A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa." [PMID:3259815] +xref: FMA:7414 is_a: UBERON:0010368 ! pulmonary lobule relationship: BFO:0000050 UBERON:0008946 ! part of lung parenchyma -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010371 name: ecto-epithelium +def: "Epithelium composed of cells that develops from the ectoderm[FMA,modified]." [FMA:69064] +xref: FMA:69064 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002202 UBERON:0000924 ! ectoderm relationship: RO:0002473 CL:0002077 ! ecto-epithelial cell +[Term] +id: UBERON:0010375 +name: pancreas dorsal primordium +xref: EHDAA2:0001384 +xref: FMA:79793 +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0009708 ! dorsal pancreas +relationship: BFO:0000050 UBERON:0003921 ! part of pancreas primordium +relationship: RO:0002387 UBERON:0009708 ! dorsal pancreas + +[Term] +id: UBERON:0010376 +name: pancreas ventral primordium +xref: EHDAA2:0001387 +xref: FMA:79794 +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0009709 ! ventral pancreas +relationship: BFO:0000050 UBERON:0003921 ! part of pancreas primordium +relationship: RO:0002387 UBERON:0009709 ! ventral pancreas + [Term] id: UBERON:0010377 name: mesenchyme from somatopleure +def: "Mesenchyme that develops_from a somatopleure." [OBOL:automatic] +xref: EHDAA2:0001120 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue @@ -42504,6 +65400,8 @@ relationship: RO:0002202 UBERON:0004874 ! somatopleure [Term] id: UBERON:0010378 name: mesenchyme from splanchnopleure +def: "Mesenchyme that develops_from a splanchnopleure." [OBOL:automatic] +xref: EHDAA2:0001122 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue @@ -42513,9 +65411,41 @@ intersection_of: RO:0002202 UBERON:0004873 ! splanchnopleure relationship: BFO:0000050 UBERON:0009142 ! part of entire embryonic mesenchyme relationship: RO:0002202 UBERON:0004873 ! splanchnopleure +[Term] +id: UBERON:0010399 +name: spleen trabecular artery +def: "One of the branches of the splenic artery[MP]." [MP:0002354, Wikipedia:Trabecular_arteries] +xref: MA:0000759 +xref: NCIT:C49775 +xref: Wikipedia:Trabecular_arteries +is_a: UBERON:0001637 ! artery +is_a: UBERON:0003497 ! abdomen blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen +relationship: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen +relationship: RO:0002252 UBERON:0001194 ! splenic artery +relationship: RO:0002433 UBERON:0002106 ! spleen + +[Term] +id: UBERON:0010400 +name: spleen trabecular vein +def: "One of the veins that feed the splenic vein." [MP:0002228, Wikipedia:Trabecular_veins] +xref: MA:0000760 +xref: NCIT:C49779 +xref: Wikipedia:Trabecular_veins +is_a: UBERON:0013126 ! vein of abdomen +intersection_of: UBERON:0001638 ! vein +intersection_of: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen +relationship: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen +relationship: RO:0002170 UBERON:0003713 ! splenic vein +relationship: RO:0002433 UBERON:0002106 ! spleen + [Term] id: UBERON:0010409 name: ocular surface region +def: "The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms." [MP:0013754] +xref: EMAPA:35336 +xref: MA:0002486 is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye @@ -42524,6 +65454,10 @@ relationship: BSPO:0000108 UBERON:0022288 ! surface of eyeball [Term] id: UBERON:0010427 name: ciliary processes +def: "The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens." [Wikipedia:Ciliary_processes] +xref: FMA:76551 +xref: SCTID:280860001 +xref: Wikipedia:Ciliary_processes is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body @@ -42531,17 +65465,32 @@ relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body [Term] id: UBERON:0010428 name: flat bone +def: "A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow." [Wikipedia:Flat_bone] +comment: Examples: cranium, the ilium, sternum, rib cage, the sacrum and the scapula; the occipital, parietal, frontal, nasal, lacrimal, vomer, scapula, os coxC&, sternum, and ribs +xref: FMA:7476 +xref: galen:FlatBone +xref: NCIT:C32616 +xref: SCTID:332907008 +xref: Wikipedia:Flat_bone is_a: UBERON:0001474 ! bone element relationship: RO:0000086 PATO:0000407 [Term] id: UBERON:0010498 name: pseudostratified columnar epithelium +def: "A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels." [http://medical-dictionary.thefreedictionary.com/pseudostratified+epithelium, Wikipedia:Pseudostratified_columnar_epithelium] +xref: FMA:45572 +xref: NCIT:C33419 +xref: NCIT:C49316 +xref: Wikipedia:Pseudostratified_columnar_epithelium is_a: UBERON:0000485 ! simple columnar epithelium [Term] id: UBERON:0010499 name: pseudostratified ciliated columnar epithelium +def: "Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile." [NCIT:NCIT] +xref: FMA:13146 +xref: NCIT:C13181 is_a: UBERON:0007592 ! ciliated columnar epithelium is_a: UBERON:0010498 ! pseudostratified columnar epithelium intersection_of: UBERON:0010498 ! pseudostratified columnar epithelium @@ -42550,18 +65499,46 @@ intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell [Term] id: UBERON:0010522 name: replacement element +def: "Skeletal element that forms as a replacement or substitution of another element or tissue." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000135] +xref: VSAO:0000135 +xref: XAO:0004016 +xref: ZFA:0005624 is_a: UBERON:0004765 ! skeletal element relationship: BFO:0000050 UBERON:0010362 ! part of endoskeleton [Term] id: UBERON:0010523 name: microcirculatory vessel +def: "A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses." [http://orcid.org/0000-0002-6601-2165, MESH:A07.231.432, ZFA:0005251] +xref: MESH:D055806 +xref: TAO:0005251 +xref: ZFA:0005251 is_a: UBERON:0000055 ! vessel relationship: BFO:0000050 UBERON:0002049 ! part of vasculature +[Term] +id: UBERON:0010527 +name: cavity of bone organ +def: "An organ cavity that surrounded_by a bone." [OBOL:automatic] +xref: FMA:24021 +is_a: UBERON:0002558 ! organ cavity +intersection_of: UBERON:0002558 ! organ cavity +intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element +relationship: BFO:0000050 UBERON:0001474 ! part of bone element + +[Term] +id: UBERON:0010528 +name: pneumatic cavity of bone +xref: FMA:24028 +is_a: UBERON:0010527 ! cavity of bone organ +relationship: BFO:0000050 UBERON:0008193 ! part of pneumatized bone + [Term] id: UBERON:0010707 name: appendage girdle complex +def: "An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." [https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton, https://orcid.org/0000-0002-6601-2165] +xref: FMA:7182 +xref: VSAO:0000214 is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000468 ! multicellular organism @@ -42571,6 +65548,10 @@ relationship: RO:0002328 GO:0040011 ! locomotion [Term] id: UBERON:0010708 name: pectoral complex +def: "Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle." [VSAO:0000213] +xref: FMA:7183 +xref: SCTID:110716002 +xref: VSAO:0000213 is_a: UBERON:0010707 ! appendage girdle complex intersection_of: UBERON:0010707 ! appendage girdle complex intersection_of: BFO:0000051 UBERON:0001421 ! has part pectoral girdle region @@ -42581,6 +65562,9 @@ relationship: RO:0002551 UBERON:0012475 ! skeleton of pectoral complex [Term] id: UBERON:0010719 name: girdle skeleton +def: "The subdivision of the skeleton of either the pectoral or pelvic girdle." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0010686 +xref: VSAO:0000302 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0007823 ! appendage girdle region @@ -42592,6 +65576,9 @@ relationship: RO:0002576 UBERON:0007823 ! appendage girdle region [Term] id: UBERON:0010740 name: bone of appendage girdle complex +def: "A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle)." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: EMAPA:35494 +xref: MA:0000688 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0010707 ! part of appendage girdle complex @@ -42602,6 +65589,9 @@ relationship: RO:0002433 UBERON:0002091 ! appendicular skeleton [Term] id: UBERON:0010741 name: bone of pectoral complex +def: "A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: EMAPA:35933 +xref: MA:0000612 is_a: UBERON:0010740 ! bone of appendage girdle complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex @@ -42610,6 +65600,11 @@ relationship: BFO:0000050 UBERON:0010708 ! part of pectoral complex [Term] id: UBERON:0010891 name: pectoral complex muscle +def: "A muscle of a pectoral girdle, pectoral fin or anterior limb." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0010687 +xref: EMAPA:32624 +xref: FMA:9621 +xref: MA:0000615 is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex @@ -42618,13 +65613,28 @@ relationship: BFO:0000050 UBERON:0014793 ! part of musculature of pectoral compl [Term] id: UBERON:0010912 name: subdivision of skeleton +def: "Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: FMA:23879 +xref: SCTID:129140006 +xref: VSAO:0000042 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0000075 ! part of subdivision of skeletal system relationship: BFO:0000050 UBERON:0004288 ! part of skeleton +[Term] +id: UBERON:0010913 +name: vertebral element +def: "Skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/294, VSAO:0000184] +xref: VHOG:0001143 +xref: VSAO:0000184 +is_a: UBERON:0004765 ! skeletal element +relationship: RO:0002202 UBERON:0003089 ! sclerotome + [Term] id: UBERON:0010959 name: craniocervical muscle +def: "Any muscle organ that is part of either the head or the neck." [http://orcid.org/0000-0002-6601-2165] +xref: NCIT:C32716 is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region @@ -42633,15 +65643,60 @@ relationship: BFO:0000050 UBERON:0008229 ! part of craniocervical region muscula [Term] id: UBERON:0011004 name: pharyngeal arch cartilage +def: "A cartilage element that is part of a splanchnocranium." [OBOL:automatic] +xref: EFO:0003689 +xref: TAO:0001460 +xref: ZFA:0001460 is_a: UBERON:0003933 ! cranial cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0008895 ! part of splanchnocranium relationship: BFO:0000050 UBERON:0008895 ! part of splanchnocranium relationship: RO:0002202 UBERON:0002539 ! pharyngeal arch +[Term] +id: UBERON:0011085 +name: palatoquadrate arch +def: "The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG]." [https://github.com/obophenotype/uberon/issues/153, VHOG:0000511] +xref: EFO:0003659 +xref: TAO:0001272 +xref: ZFA:0001272 +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010912 ! subdivision of skeleton +relationship: BFO:0000050 UBERON:0003277 ! part of skeleton of upper jaw +relationship: BFO:0000050 UBERON:0008895 ! part of splanchnocranium +relationship: RO:0002202 UBERON:0004362 ! pharyngeal arch 1 + +[Term] +id: UBERON:0011094 +name: vertebra cartilage element +def: "The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, http://orcid.org/0000-0002-6601-2165, VSAO:0000184] +xref: EMAPA:32669 +xref: VHOG:0000584 +is_a: UBERON:0007844 ! cartilage element +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue +relationship: RO:0002202 UBERON:0011095 ! vertebra pre-cartilage condensation +relationship: RO:0002387 UBERON:0002412 ! vertebra + +[Term] +id: UBERON:0011095 +name: vertebra pre-cartilage condensation +def: "The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, http://orcid.org/0000-0002-6601-2165, VSAO:0000184] +xref: EMAPA:32671 +xref: VHOG:0000582 +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: RO:0002473 UBERON:0005866 ! pre-cartilage condensation +relationship: RO:0002387 UBERON:0002412 ! vertebra +relationship: RO:0002473 UBERON:0005866 ! pre-cartilage condensation + [Term] id: UBERON:0011108 name: synovial joint of pectoral girdle +def: "A synovial joint that is part of a pectoral girdle region." [OBOL:automatic] +xref: FMA:35243 +xref: SCTID:303080001 is_a: UBERON:0002217 ! synovial joint is_a: UBERON:0008114 ! joint of girdle intersection_of: UBERON:0002217 ! synovial joint @@ -42652,23 +65707,48 @@ relationship: RO:0002176 UBERON:0007829 ! pectoral girdle bone [Term] id: UBERON:0011134 name: nonsynovial joint +def: "Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis." [FMA:7491] +xref: FMA:7491 is_a: UBERON:0000982 ! skeletal joint [Term] id: UBERON:0011137 name: axial skeletal system +def: "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:7483 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000051 UBERON:0000982 ! has part skeletal joint [Term] id: UBERON:0011138 name: postcranial axial skeletal system +def: "Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints." [https://github.com/obophenotype/uberon/issues/44, https://orcid.org/0000-0002-6601-2165] +xref: FMA:302077 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: RO:0002202 UBERON:0003089 ! sclerotome +[Term] +id: UBERON:0011148 +name: submucosal gland +def: "Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue." [BTO:0003751, Wikipedia:Submucosal_glands] +xref: BTO:0003751 +xref: Wikipedia:Submucosal_glands +is_a: UBERON:0000414 ! mucous gland +intersection_of: UBERON:0000414 ! mucous gland +intersection_of: RO:0001025 UBERON:0000009 ! submucosa +relationship: RO:0001025 UBERON:0000009 ! submucosa +relationship: RO:0002150 UBERON:0003350 ! epithelium of mucosa + [Term] id: UBERON:0011156 name: facial skeleton +def: "Subdivision of skull that consists of the facial bones." [http://www.bartleby.com/107/37.html, https://orcid.org/0000-0002-6601-2165, MP:0005274, Wikipedia:Facial_skeleton] +xref: EHDAA2:0002206 +xref: EHDAA:8361 +xref: EMAPA:18022 +xref: FMA:53673 +xref: MA:0000318 +xref: Wikipedia:Facial_skeleton is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011158 ! primary subdivision of skull relationship: BFO:0000050 UBERON:0001456 ! part of face @@ -42676,6 +65756,8 @@ relationship: BFO:0000050 UBERON:0001456 ! part of face [Term] id: UBERON:0011158 name: primary subdivision of skull +def: "The skull can be divided into two: the neurocranium and the facial skeleton." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:54964 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0003129 ! part of skull @@ -42688,15 +65770,77 @@ relationship: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system [Term] id: UBERON:0011164 name: neurocranium bone +def: "A bone that is part of a neurocranium [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35238 +xref: MA:0001478 +xref: SCTID:120229002 is_a: UBERON:0003457 ! head bone is_a: UBERON:0004766 ! cranial bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001703 ! part of neurocranium relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium +[Term] +id: UBERON:0011171 +name: joint connecting upper and lower jaws +def: "Synovial joint that articulates bones of upper and lower jaw." [http://evolution.berkeley.edu/evolibrary/article/evograms_05, https://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0002217 ! synovial joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: RO:0002176 UBERON:0003277 ! skeleton of upper jaw +intersection_of: RO:0002176 UBERON:0003278 ! skeleton of lower jaw +relationship: RO:0002176 UBERON:0003277 ! skeleton of upper jaw +relationship: RO:0002176 UBERON:0003278 ! skeleton of lower jaw + +[Term] +id: UBERON:0011185 +name: gastrointestinal sphincter +def: "A sphincter muscle that is part of the gastrointestinal system." [OBOL:automatic] +xref: NCIT:C32669 +is_a: UBERON:0004590 ! sphincter muscle +is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system +relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system + +[Term] +id: UBERON:0011189 +name: lamina propria of large intestine +def: "A lamina propria that is part of a large intestine." [OBOL:automatic] +xref: FMA:15654 +xref: NCIT:C49298 +is_a: UBERON:0004780 ! gastrointestinal system lamina propria +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001207 ! part of mucosa of large intestine + +[Term] +id: UBERON:0011198 +name: muscle layer of large intestine +def: "A muscle layer that is part of a large intestine." [OBOL:automatic] +xref: FMA:14971 +xref: NCIT:C32927 +is_a: UBERON:0012367 ! muscle layer of intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine + +[Term] +id: UBERON:0011201 +name: muscle layer of small intestine +def: "A muscle layer that is part of a small intestine." [OBOL:automatic] +xref: FMA:14932 +xref: NCIT:C33569 +xref: SCTID:362145004 +is_a: UBERON:0012367 ! muscle layer of intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine + [Term] id: UBERON:0011215 name: central nervous system cell part cluster +def: "A multi cell part structure that is part of a central nervous system." [OBOL:automatic] +xref: FMA:83143 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005162 ! multi cell part structure intersection_of: UBERON:0005162 ! multi cell part structure @@ -42706,16 +65850,18 @@ relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system [Term] id: UBERON:0011216 name: organ system subdivision +def: "A subdivision of an anatomical system." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:67509 +xref: SCTID:91690000 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000467 ! part of anatomical system -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011222 name: intra-ocular muscle +xref: AAO:0010038 +xref: EMAPA:18808 +xref: FMA:49150 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004277 ! eye muscle relationship: BFO:0000050 UBERON:0003386 ! part of smooth muscle of eye @@ -42723,6 +65869,11 @@ relationship: BFO:0000050 UBERON:0003386 ! part of smooth muscle of eye [Term] id: UBERON:0011233 name: synovial membrane of synovial tendon sheath +def: "Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa." [FMA:45087, Wikipedia:Synovial_sheath] +comment: Alternate def: A synovial sheath is a layer of a tendon sheath containing tendons in the hand and foot. They lie internal to the fibrous tendon sheaths. An example is the common synovial sheath for the flexor tendons. [Wikipedia:Synovial_sheath] +xref: BTO:0001823 +xref: FMA:40878 +xref: Wikipedia:Synovial_sheath is_a: UBERON:0007616 ! layer of synovial tissue intersection_of: UBERON:0007616 ! layer of synovial tissue intersection_of: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath @@ -42731,6 +65882,7 @@ relationship: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath [Term] id: UBERON:0011234 name: fibrous membrane of synovial tendon sheath +xref: FMA:40877 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath @@ -42738,9 +65890,21 @@ intersection_of: RO:0002473 UBERON:0011824 ! fibrous connective tissue relationship: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath relationship: RO:0002473 UBERON:0011824 ! fibrous connective tissue +[Term] +id: UBERON:0011241 +name: ethmoid region +def: "The most anterior region of the braincase. Provides structural support for peripheral olfactory organ." [http://palaeos.com/vertebrates/bones/braincase/ethmoid.html, UBERONREF:0000007] +xref: AAO:0000986 +is_a: UBERON:0034921 ! multi organ part structure +relationship: BFO:0000050 UBERON:0003112 ! part of olfactory region +relationship: RO:0002254 UBERON:0005945 ! neurocranial trabecula + [Term] id: UBERON:0011249 name: appendicular skeletal system +def: "Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:7484 +xref: VSAO:0000306 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000051 UBERON:0000982 ! has part skeletal joint relationship: BFO:0000051 UBERON:0002091 ! has part appendicular skeleton @@ -42748,12 +65912,18 @@ relationship: BFO:0000051 UBERON:0002091 ! has part appendicular skeleton [Term] id: UBERON:0011270 name: dorsal trunk +def: "The part of the trunk that is in the dorsum[cjm]." [UBERONREF:0000006, Wikipedia:Human_back] +xref: EMAPA:35162 +xref: FMA:25056 +xref: MA:0000020 +xref: Wikipedia:Human_back is_a: UBERON:0009569 ! subdivision of trunk relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0011272 name: embryonic skin basal layer +xref: EHDAA2:0001845 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0010371 ! ecto-epithelium relationship: BFO:0000050 UBERON:0002199 ! part of integument @@ -42762,6 +65932,9 @@ relationship: RO:0002202 UBERON:0000076 ! external ectoderm [Term] id: UBERON:0011362 name: cranial blood vasculature +def: "A blood vasculature that is part of a head." [OBOL:automatic] +xref: TAO:0005297 +xref: ZFA:0005297 is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0004537 ! blood vasculature intersection_of: UBERON:0004537 ! blood vasculature @@ -42770,12 +65943,18 @@ intersection_of: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0011565 name: lumen of gastrointestinal system +xref: FMA:54364 +xref: SCTID:432899004 is_a: UBERON:0002553 ! anatomical cavity relationship: BFO:0000050 UBERON:0001007 ! part of digestive system [Term] id: UBERON:0011566 name: lumen of esophagus +def: "An anatomical cavity that is part of a esophagus." [OBOL:automatic] +xref: EMAPA:18380 +xref: FMA:9398 +xref: SCTID:322648002 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001043 ! esophagus @@ -42786,6 +65965,8 @@ relationship: RO:0002572 UBERON:0001043 ! esophagus [Term] id: UBERON:0011582 name: paired limb/fin skeleton +def: "The collection of all skeletal elements in an individual limb or fin." [https://orcid.org/0000-0002-6601-2165] +xref: VSAO:0000301 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton @@ -42798,11 +65979,26 @@ relationship: RO:0002576 UBERON:0004708 ! paired limb/fin [Term] id: UBERON:0011585 name: cell condensation +def: "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995)." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000006] +xref: VSAO:0000006 +xref: XAO:0004021 is_a: UBERON:0000061 ! anatomical structure +[Term] +id: UBERON:0011592 +name: future upper lip +xref: EHDAA2:0002120 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0003235 ! epithelium of upper jaw +relationship: RO:0002202 UBERON:0004068 ! medial nasal prominence +relationship: RO:0002202 UBERON:0005868 ! maxillary prominence + [Term] id: UBERON:0011595 name: jaw region +def: "A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:32905 +xref: NCIT:C114916 is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000475 ! organism subdivision @@ -42814,13 +66010,25 @@ relationship: RO:0002551 UBERON:0001708 ! jaw skeleton [Term] id: UBERON:0011596 name: future lower lip +xref: EHDAA2:0001020 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003236 ! epithelium of lower jaw relationship: RO:0002202 UBERON:0005867 ! mandibular prominence +[Term] +id: UBERON:0011597 +name: bone of upper jaw +def: "Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species)." [https://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0012360 ! bone of jaw +intersection_of: UBERON:0001474 ! bone element +intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: BFO:0000050 UBERON:0003277 ! part of skeleton of upper jaw + [Term] id: UBERON:0011642 name: oral epithelium from ectoderm +def: "An epithelium that develops_from a ectoderm and is part of a oral epithelium." [OBOL:automatic] +xref: EHDAA2:0004137 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0002424 ! oral epithelium is_a: UBERON:0010371 ! ecto-epithelium @@ -42833,18 +66041,39 @@ relationship: RO:0002202 UBERON:0009479 ! ectoderm of buccopharyngeal membrane [Term] id: UBERON:0011648 name: jaw muscle +xref: AAO:0000247 +xref: EFO:0003511 +xref: TAO:0000236 +xref: XAO:0003269 +xref: ZFA:0000236 is_a: UBERON:0002376 ! cranial muscle relationship: RO:0002216 GO:0071626 ! capable of part of mastication [Term] id: UBERON:0011676 name: subdivision of organism along main body axis +def: "A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0013701 ! part of main body axis +[Term] +id: UBERON:0011677 +name: trunk vertebra +def: "A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly." [UBERONREF:0000006] +is_a: UBERON:0003463 ! trunk bone +is_a: UBERON:0004247 ! bone of dorsum +is_a: UBERON:0004451 ! trunk or cervical vertebra +intersection_of: UBERON:0002412 ! vertebra +intersection_of: BFO:0000050 UBERON:0009568 ! part of trunk region of vertebral column +relationship: BFO:0000050 UBERON:0009568 ! part of trunk region of vertebral column + [Term] id: UBERON:0011695 name: embryonic cardiovascular system +def: "A cardiovascular system that is part of a conceptus." [OBOL:automatic] +xref: EHDAA2:0000216 +xref: FMA:305965 +xref: NCIT:C34148 is_a: UBERON:0004535 ! cardiovascular system intersection_of: UBERON:0004535 ! cardiovascular system intersection_of: BFO:0000050 UBERON:0004716 ! part of conceptus @@ -42853,15 +66082,30 @@ relationship: BFO:0000050 UBERON:0004716 ! part of conceptus [Term] id: UBERON:0011772 name: lower jaw opening +def: "An anatomical space that is part of a bone of lower jaw." [OBOL:automatic] +xref: AAO:0000273 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0004768 ! bone of lower jaw relationship: BFO:0000050 UBERON:0004768 ! part of bone of lower jaw relationship: RO:0002572 UBERON:0004768 ! bone of lower jaw +[Term] +id: UBERON:0011773 +name: upper jaw opening +def: "An anatomical space that is part of a bone of upper jaw." [OBOL:automatic] +xref: AAO:0000621 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0011597 ! bone of upper jaw +relationship: BFO:0000050 UBERON:0011597 ! part of bone of upper jaw +relationship: RO:0002572 UBERON:0011597 ! bone of upper jaw + [Term] id: UBERON:0011777 name: nucleus of spinal cord +def: "A neural nucleus that is part of the spinal cord." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:77011 is_a: UBERON:0000125 ! neural nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord @@ -42870,6 +66114,7 @@ relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord [Term] id: UBERON:0011779 name: nerve of head region +def: "A nerve that is part of a head." [OBOL:automatic] is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -42878,11 +66123,15 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0011814 name: non-neurogenic ectodermal placode +def: "Ectodermal placode that does not develop into a component of the nervous system." [http://orcid.org/0000-0002-6601-2165, PMID:11523831] is_a: UBERON:0005085 ! ectodermal placode [Term] id: UBERON:0011820 name: atrioventricular region +def: "An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0004149 +xref: FMA:85125 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction @@ -42892,16 +66141,21 @@ intersection_of: RO:0002176 UBERON:0002082 ! cardiac ventricle relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002176 UBERON:0002081 ! cardiac atrium relationship: RO:0002176 UBERON:0002082 ! cardiac ventricle -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011821 name: irregular connective tissue +def: "Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium." [FMA:20107] +xref: FMA:20107 is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0011822 name: dense irregular connective tissue +def: "Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium." [FMA:20109, Wikipedia:Dense_irregular_connective_tissue] +xref: FMA:20109 +xref: NCIT:C32882 +xref: Wikipedia:Dense_irregular_connective_tissue is_a: UBERON:0011821 ! irregular connective tissue is_a: UBERON:0011823 ! dense connective tissue intersection_of: UBERON:0011821 ! irregular connective tissue @@ -42912,6 +66166,10 @@ relationship: BFO:0000051 GO:0071953 ! has part elastic fiber [Term] id: UBERON:0011823 name: dense connective tissue +def: "Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets." [Wikipedia:Dense_connective_tissue] +xref: AAO:0000121 +xref: NCIT:C32450 +xref: Wikipedia:Dense_connective_tissue is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002473 UBERON:0011860 ! collection of collagen fibrils @@ -42921,16 +66179,23 @@ relationship: RO:0002473 UBERON:0011860 ! collection of collagen fibrils [Term] id: UBERON:0011824 name: fibrous connective tissue +xref: FMA:75634 +xref: SCTID:363130003 is_a: UBERON:0011822 ! dense irregular connective tissue [Term] id: UBERON:0011825 name: loose connective tissue +def: "Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue." [FMA:19783] +xref: FMA:19783 +xref: NCIT:C33007 +xref: Wikipedia:Loose_connective_tissue is_a: UBERON:0011821 ! irregular connective tissue [Term] id: UBERON:0011858 name: acinus of exocrine gland +def: "An acinus that is part of a exocrine gland." [OBOL:automatic] is_a: UBERON:0009842 ! glandular acinus intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0002365 ! part of exocrine gland @@ -42939,6 +66204,10 @@ relationship: BFO:0000050 UBERON:0002365 ! part of exocrine gland [Term] id: UBERON:0011860 name: collection of collagen fibrils +xref: FMA:63212 +xref: MESH:D024022 +xref: NCIT:C32339 +xref: NIF_Subcellular:sao7547390221 is_a: UBERON:0000476 ! acellular anatomical structure relationship: RO:0002473 GO:0005581 ! collagen trimer relationship: RO:0002473 GO:0098643 ! banded collagen fibril @@ -42946,6 +66215,7 @@ relationship: RO:0002473 GO:0098643 ! banded collagen fibril [Term] id: UBERON:0011861 name: aorta collagen fibril +def: "The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011640] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils @@ -42956,6 +66226,7 @@ relationship: RO:0002433 UBERON:0004664 ! aorta tunica adventitia [Term] id: UBERON:0011862 name: pulmonary collagen fibril +def: "The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011641] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils @@ -42966,6 +66237,7 @@ relationship: RO:0002433 UBERON:0002048 ! lung [Term] id: UBERON:0011863 name: bone collagen fibril +def: "The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011642] is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element @@ -42974,6 +66246,7 @@ relationship: BFO:0000050 UBERON:0001474 ! part of bone element [Term] id: UBERON:0011864 name: tendon collagen fibril +def: "The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011643] is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils intersection_of: BFO:0000050 UBERON:0000043 ! part of tendon @@ -42983,6 +66256,7 @@ relationship: RO:0002433 UBERON:0000043 ! tendon [Term] id: UBERON:0011865 name: corneal stroma collagen fibril +def: "The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011650] is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils @@ -42990,9 +66264,22 @@ intersection_of: BFO:0000050 UBERON:0001777 ! part of substantia propria of corn relationship: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea relationship: RO:0002433 UBERON:0001777 ! substantia propria of cornea +[Term] +id: UBERON:0011878 +name: muscle layer of esophagus +def: "A muscle layer that is part of a wall of esophagus." [OBOL:automatic] +xref: FMA:62998 +is_a: UBERON:0018261 ! muscular coat of digestive tract +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus +relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus +relationship: BFO:0000051 UBERON:0001134 ! has part skeletal muscle tissue + [Term] id: UBERON:0011892 name: anterior uvea +def: "Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris." [MP:0005194] +xref: SCTID:280656002 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001768 ! part of uvea @@ -43004,6 +66291,10 @@ relationship: RO:0002433 UBERON:0001801 ! anterior segment of eyeball [Term] id: UBERON:0011899 name: epimysium +def: "Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous." [Wikipedia:Epimysium] +xref: FMA:9726 +xref: NCIT:C32527 +xref: Wikipedia:Epimysium is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0011822 ! dense irregular connective tissue relationship: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue @@ -43013,6 +66304,9 @@ relationship: RO:0002150 UBERON:0000043 ! tendon [Term] id: UBERON:0011919 name: yolk sac blood island +def: "Masses of developing blood cells attached to endothelium in the yolk sac." [MP:0011204] +xref: EHDAA2:0000177 +xref: EMAPA:16115 is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0003061 ! blood island intersection_of: UBERON:0003061 ! blood island @@ -43023,34 +66317,94 @@ relationship: RO:0002202 UBERON:0003316 ! mesenchyme of yolk sac [Term] id: UBERON:0011953 name: stomach glandular region +def: "A region of the stomach that is lined with glandular epithelium." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:17623 +xref: MA:0001613 +xref: NCIT:C77661 +xref: SCTID:27633001 is_a: UBERON:0009870 ! zone of stomach intersection_of: UBERON:0009870 ! zone of stomach intersection_of: BFO:0000051 UBERON:0006924 ! has part stomach glandular epithelium relationship: BFO:0000051 UBERON:0006924 ! has part stomach glandular epithelium +[Term] +id: UBERON:0011955 +name: left hepatic vein +def: "A hepatic vein that is part of a left lobe of liver." [OBOL:automatic] +xref: FMA:14339 +xref: MA:0003032 +xref: SCTID:55188000 +is_a: UBERON:0001143 ! hepatic vein +intersection_of: UBERON:0001143 ! hepatic vein +intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: BFO:0000050 UBERON:0001115 ! part of left lobe of liver + +[Term] +id: UBERON:0011956 +name: right hepatic vein +def: "A hepatic vein that is part of a right lobe of liver." [OBOL:automatic] +xref: FMA:14338 +xref: MA:0003034 +xref: SCTID:18135006 +is_a: UBERON:0001143 ! hepatic vein +intersection_of: UBERON:0001143 ! hepatic vein +intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: BFO:0000050 UBERON:0001114 ! part of right lobe of liver + [Term] id: UBERON:0011997 name: coelom +def: "The aggregate of the coelemic cavity lumen plus the membranes that line the lumen." [UBERON:cjm, Wikipedia:Body_cavity, Wikipedia:Coelom] +xref: EHDAA2:0004731 +xref: Wikipedia:Coelom is_a: UBERON:0000481 ! multi-tissue structure relationship: RO:0002160 NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0012054 name: myocoele +def: "The cavity within a myotome." [http://medical-dictionary.thefreedictionary.com/myocoele] +xref: EMAPA:31134 +xref: VHOG:0001283 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0003082 ! myotome relationship: RO:0002572 UBERON:0003082 ! myotome +[Term] +id: UBERON:0012071 +name: palate bone +def: "Any bone that is part of a palate." [https://orcid.org/0000-0002-6601-2165] +xref: NCIT:C33248 +is_a: UBERON:0003457 ! head bone +is_a: UBERON:0008907 ! dermal bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: BFO:0000050 UBERON:0007375 ! part of roof of mouth +relationship: BFO:0000050 UBERON:0012072 ! part of palatal part of dermatocranium + +[Term] +id: UBERON:0012072 +name: palatal part of dermatocranium +is_a: UBERON:0000075 ! subdivision of skeletal system +relationship: BFO:0000050 UBERON:0003113 ! part of dermatocranium +relationship: BFO:0000050 UBERON:0007375 ! part of roof of mouth + [Term] id: UBERON:0012075 name: replacement bone +def: "Bone that forms as a replacement of another structural tissue." [ZFA:0001628] +xref: AAO:0010768 +xref: TAO:0001637 +xref: ZFA:0001628 is_a: UBERON:0001474 ! bone element is_a: UBERON:0010522 ! replacement element [Term] id: UBERON:0012082 name: bronchial lumen +def: "An anatomical cavity that is part of a bronchus." [OBOL:automatic] +xref: FMA:62646 +xref: SCTID:199401001 is_a: UBERON:0000464 ! anatomical space relationship: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: RO:0002572 UBERON:0002185 ! bronchus @@ -43058,6 +66412,9 @@ relationship: RO:0002572 UBERON:0002185 ! bronchus [Term] id: UBERON:0012172 name: stomach primordium +def: "A primordium that has the potential to develop into a stomach." [OBOL:automatic] +xref: EFO:0002580 +xref: NCIT:C34305 is_a: UBERON:0001048 ! primordium intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0000945 ! stomach @@ -43067,6 +66424,9 @@ relationship: RO:0002387 UBERON:0000945 ! stomach [Term] id: UBERON:0012180 name: head or neck skin +def: "A zone of skin that is part of a craniocervical region." [OBOL:automatic] +xref: MA:0000574 +xref: NCIT:C12294 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region @@ -43075,6 +66435,9 @@ relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region [Term] id: UBERON:0012193 name: phrenic vein +def: "The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins." [ncithesaurus:Phrenic_Vein] +xref: MA:0002194 +xref: NCIT:C53062 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0001103 ! diaphragm @@ -43083,6 +66446,8 @@ relationship: RO:0002179 UBERON:0001103 ! diaphragm [Term] id: UBERON:0012254 name: abdominal aorta artery +def: "An artery that originates from the abdominal aorta." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Abdominal_aorta#Branches] +xref: SCTID:281470000 is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002380 UBERON:0001516 ! abdominal aorta @@ -43091,12 +66456,16 @@ relationship: RO:0002380 UBERON:0001516 ! abdominal aorta [Term] id: UBERON:0012274 name: columnar epithelium +def: "An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]." [Wikipedia:Columnar_epithelium] +xref: Wikipedia:Columnar_epithelium is_a: UBERON:0000483 ! epithelium relationship: BFO:0000051 CL:0000075 ! has part columnar/cuboidal epithelial cell [Term] id: UBERON:0012275 name: meso-epithelium +def: "Epithelium that derives from the mesoderm. [Automatically generated definition]." [OBOL:automatic] +xref: FMA:86452 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000483 ! epithelium @@ -43105,6 +66474,9 @@ intersection_of: RO:0002202 UBERON:0000926 ! mesoderm [Term] id: UBERON:0012314 name: embryonic facial prominence +def: "One of five swellings formed during the development of the face." [http://www.indiana.edu/~anat550/hnanim/face/face.html] +xref: FMA:293103 +xref: SCTID:89066004 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -43112,6 +66484,8 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0012320 name: cervical artery +def: "An artery of the neck." [https://orcid.org/0000-0002-6601-2165] +xref: NCIT:C52850 is_a: UBERON:0001637 ! artery is_a: UBERON:0003502 ! neck blood vessel intersection_of: UBERON:0001637 ! artery @@ -43120,31 +66494,65 @@ intersection_of: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0012321 name: deep cervical artery +def: "The deep cervical artery (Profunda cervicalis) is an artery of the neck." [Wikipedia:Deep_cervical_artery] +xref: FMA:10659 +xref: SCTID:244223002 +xref: Wikipedia:Deep_cervical_artery is_a: UBERON:0012320 ! cervical artery intersection_of: UBERON:0012320 ! cervical artery intersection_of: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: RO:0002252 UBERON:0004688 ! costo-cervical trunk -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012324 name: transverse cervical artery +def: "The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery." [Wikipedia:Transverse_cervical_artery] +xref: FMA:10664 +xref: MA:0001936 +xref: SCTID:244224008 +xref: Wikipedia:Transverse_cervical_artery is_a: UBERON:0012320 ! cervical artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012360 name: bone of jaw +def: "A bone element that is part of a jaw region." [OBOL:automatic] +xref: EMAPA:35453 +xref: MA:0003130 +xref: SCTID:369003004 is_a: UBERON:0003462 ! facial bone is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0011595 ! part of jaw region relationship: BFO:0000050 UBERON:0001708 ! part of jaw skeleton +[Term] +id: UBERON:0012361 +name: internal anal region +xref: EHDAA2:0004588 +is_a: UBERON:0000481 ! multi-tissue structure +relationship: BFO:0000050 UBERON:0001353 ! part of anal region + +[Term] +id: UBERON:0012367 +name: muscle layer of intestine +def: "A muscle layer that is part of an intestine." [OBOL:automatic] +xref: FMA:15697 +is_a: UBERON:0018261 ! muscular coat of digestive tract +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine + [Term] id: UBERON:0012375 name: subserosa +def: "A layer of tissue between the muscularis and serosa." [Wikipedia:Subserosa] +comment: Contains nerves, blood vessels, lymphatics and lymph nodes +xref: FMA:45636 +xref: NCIT:C94494 +xref: SCTID:2255006 +xref: Wikipedia:Subserosa is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002220 UBERON:0000042 ! adjacent to serous membrane @@ -43152,30 +66560,54 @@ intersection_of: RO:0002473 UBERON:0006815 ! areolar connective tissue relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002220 UBERON:0000042 ! adjacent to serous membrane relationship: RO:0002473 UBERON:0006815 ! areolar connective tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012416 name: respiratory system arterial smooth muscle +xref: MA:0001802 is_a: UBERON:0004297 ! respiratory system blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003643 ! part of respiratory system arterial blood vessel relationship: BFO:0000050 UBERON:0003643 ! part of respiratory system arterial blood vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012418 name: respiratory system venous smooth muscle +def: "A smooth muscle tissue that is part of a respiratory system venous blood vessel." [OBOL:automatic] +xref: MA:0001812 is_a: UBERON:0004696 ! venous system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003476 ! part of respiratory system venous blood vessel relationship: BFO:0000050 UBERON:0003476 ! part of respiratory system venous blood vessel -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0012423 +name: layer of microvilli +def: "A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]." [GO:0005902, Wikipedia:Microvillus] +xref: FMA:67296 +xref: MESH:D008871 +xref: NCIT:C33112 +xref: Wikipedia:Microvillus +is_a: UBERON:0005162 ! multi cell part structure +relationship: RO:0002473 GO:0005902 ! microvillus + +[Term] +id: UBERON:0012425 +name: striated border microvillus layer +def: "A microvillus layer that is striated and found in the intestine." [http://medical-dictionary.thefreedictionary.com/striated+border, http://orcid.org/0000-0002-6601-2165] +xref: FMA:70978 +xref: NCIT:C33634 +is_a: UBERON:0012423 ! layer of microvilli +relationship: BFO:0000050 UBERON:0000160 ! part of intestine [Term] id: UBERON:0012429 name: hematopoietic tissue +def: "Blood-forming tissue, consisting of reticular fibers and cells." [http://encyclopedia2.thefreedictionary.com/hematopoietic+tissue] +xref: CALOHA:TS-2142 +xref: FMA:14073 +xref: NCIT:C13051 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0034769 ! lymphomyeloid tissue intersection_of: UBERON:0000479 ! tissue @@ -43186,6 +66618,10 @@ relationship: site_of GO:0030097 ! hemopoiesis [Term] id: UBERON:0012430 name: tunica fibrosa of eyeball +def: "The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth." [Wikipedia:Fibrous_tunic_of_eyeball] +xref: FMA:58102 +xref: SCTID:361318005 +xref: Wikipedia:Fibrous_tunic_of_eyeball is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004923 ! organ component layer is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -43193,9 +66629,44 @@ relationship: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye relationship: BFO:0000051 UBERON:0000964 ! has part cornea relationship: BFO:0000051 UBERON:0001773 ! has part sclera +[Term] +id: UBERON:0012463 +name: cloacal lumen +def: "An anatomical space that is enclosed by a cloaca." [OBOL:automatic] +xref: TAO:0000330 +xref: ZFA:0000330 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0000162 ! cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0012465 ! part of lumen of terminal part of digestive tract +relationship: RO:0002572 UBERON:0000162 ! cloaca + +[Term] +id: UBERON:0012464 +name: cloacal vent +def: "The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0000161 ! orifice +intersection_of: UBERON:0000161 ! orifice +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012465 +name: lumen of terminal part of digestive tract +def: "An anatomical space that is enclosed by a terminal part of digestive tract." [OBOL:automatic] +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0006866 ! terminal part of digestive tract +relationship: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract +relationship: RO:0002572 UBERON:0006866 ! terminal part of digestive tract + [Term] id: UBERON:0012466 name: extraembryonic cavity +xref: EHDAA2:0000472 +xref: EMAPA:16054 +xref: VHOG:0000767 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component @@ -43204,14 +66675,25 @@ relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic compone [Term] id: UBERON:0012467 name: enclosed anatomical space +def: "An anatomical space with no opening to another space or to the exterior." [AEO:0000222] +xref: AEO:0000222 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0000086 PATO:0000608 relationship: RO:0000086 PATO:0000608 +[Term] +id: UBERON:0012469 +name: external anal region +xref: EHDAA2:0004589 +is_a: UBERON:0000481 ! multi-tissue structure +relationship: BFO:0000050 UBERON:0001353 ! part of anal region + [Term] id: UBERON:0012475 name: skeleton of pectoral complex +def: "The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:24139 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0010708 ! pectoral complex @@ -43219,17 +66701,161 @@ relationship: BFO:0000050 UBERON:0002091 ! part of appendicular skeleton relationship: BFO:0000050 UBERON:0010708 ! part of pectoral complex relationship: RO:0002576 UBERON:0010708 ! pectoral complex +[Term] +id: UBERON:0012477 +name: dorsal part of neck +def: "The posterior region of the neck, including the suboccipital region." [MP:0012723] +xref: BTO:0000957 +xref: FMA:24189 +xref: SCTID:182326009 +xref: SCTID:304036007 +is_a: UBERON:0005434 ! cervical region +relationship: BFO:0000050 UBERON:0001137 ! part of dorsum +relationship: BSPO:0015101 UBERON:0000974 ! neck + +[Term] +id: UBERON:0012478 +name: cloacal gland +def: "A gland that is part of a cloaca." [OBOL:automatic] +is_a: UBERON:0003408 ! gland of digestive tract +intersection_of: UBERON:0002530 ! gland +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012480 +name: cloacal mucosa +def: "A mucosa that is part of a cloaca [Automatically generated definition]." [OBOL:automatic] +is_a: UBERON:0000344 ! mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012481 +name: cloacal epithelium +def: "An epithelium that is part of a cloaca." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:27577 +xref: EMAPA:36070 +xref: ZFA:0005783 +is_a: UBERON:0003929 ! digestive tract epithelium +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012482 +name: submucosa of cloaca +def: "A submucosa that is part of a cloaca [Automatically generated definition]." [OBOL:automatic] +is_a: UBERON:0018257 ! submucosa of digestive tract +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012483 +name: serosa of cloaca +def: "A serous membrane that is part of a cloaca [Automatically generated definition]." [OBOL:automatic] +is_a: UBERON:0000042 ! serous membrane +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012485 +name: cloacal villus +is_a: UBERON:0012423 ! layer of microvilli +intersection_of: UBERON:0012423 ! layer of microvilli +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012486 +name: muscle layer of cloaca +def: "A muscular coat that is part of a cloaca." [OBOL:automatic] +is_a: UBERON:0018261 ! muscular coat of digestive tract +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012488 +name: muscle layer of duodenum +def: "A muscular coat that is part of a duodenum." [OBOL:automatic] +xref: FMA:14944 +xref: SCTID:362147007 +is_a: UBERON:0011201 ! muscle layer of small intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + +[Term] +id: UBERON:0012489 +name: muscle layer of colon +def: "A muscular coat that is part of a colon." [OBOL:automatic] +xref: EMAPA:27383 +xref: FMA:14986 +xref: MA:0003198 +xref: SCTID:362158003 +is_a: UBERON:0011198 ! muscle layer of large intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0012490 +name: muscle layer of anal canal +def: "A muscular coat that is part of a anal canal." [OBOL:automatic] +xref: FMA:15708 +xref: SCTID:362171000 +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0011198 ! muscle layer of large intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal + [Term] id: UBERON:0012504 name: adventitia of esophagus +def: "An adventitia that is part of a esophagus." [OBOL:automatic] +xref: FMA:63006 +xref: SCTID:85950006 is_a: UBERON:0005742 ! adventitia intersection_of: UBERON:0005742 ! adventitia intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus +[Term] +id: UBERON:0012650 +name: gastroduodenal junction +def: "An anatomical junction that connects a stomach and connects a duodenum." [OBOL:automatic] +xref: FMA:17046 +xref: SCTID:264014000 +is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0000945 ! stomach +intersection_of: RO:0002176 UBERON:0002114 ! duodenum +relationship: BFO:0000050 UBERON:0000945 ! part of stomach +relationship: RO:0002176 UBERON:0000945 ! stomach +relationship: RO:0002176 UBERON:0002114 ! duodenum + +[Term] +id: UBERON:0012651 +name: mucosa of gastroduodenal junction +def: "A mucosa that is part of a gastroduodenal junction." [OBOL:automatic] +xref: BTO:0005415 +is_a: UBERON:0001199 ! mucosa of stomach +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0012650 ! part of gastroduodenal junction +relationship: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach +relationship: BFO:0000050 UBERON:0012650 ! part of gastroduodenal junction + [Term] id: UBERON:0013126 name: vein of abdomen +def: "A vein that is part of a abdomen." [OBOL:automatic] +xref: SCTID:281473003 is_a: UBERON:0001638 ! vein is_a: UBERON:0003497 ! abdomen blood vessel intersection_of: UBERON:0001638 ! vein @@ -43238,6 +66864,8 @@ intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0013127 name: pulmonary venous system +def: "The part of the venous system that drains the lungs[Kardong]." [ISBN:0073040584, Wikipedia:Pulmonary_venous_system] +xref: Wikipedia:Pulmonary_venous_system is_a: UBERON:0002049 ! vasculature relationship: BFO:0000050 UBERON:0004582 ! part of venous system relationship: channels_from UBERON:0000102 ! lung vasculature @@ -43245,6 +66873,8 @@ relationship: channels_from UBERON:0000102 ! lung vasculature [Term] id: UBERON:0013136 name: vein of lip +def: "A vein that drains a lip." [OBOL:automatic] +xref: SCTID:367664002 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0001833 ! lip @@ -43254,14 +66884,40 @@ relationship: RO:0002376 UBERON:0001653 ! facial vein [Term] id: UBERON:0013140 name: systemic vein +def: "Any vein within the general circulation that transports blood back to the right atrium of the heart." [ncithesaurus:Systemic_Vein] +xref: FMA:66644 +xref: NCIT:C33719 +xref: SCTID:244389004 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0004581 ! part of systemic venous system relationship: BFO:0000050 UBERON:0004581 ! part of systemic venous system +[Term] +id: UBERON:0013158 +name: foregut-midgut junction gland +def: "A gland that is part of a foregut-midgut junction." [OBOL:automatic] +xref: EHDAA2:0000574 +xref: EMAPA:17065 +is_a: UBERON:0003408 ! gland of digestive tract +intersection_of: UBERON:0002530 ! gland +intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction + +[Term] +id: UBERON:0013212 +name: anal sac gland secretion +def: "A bodily secretion that is produced by a gland of anal sac." [OBOL:automatic] +is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: RO:0003001 UBERON:0004760 ! produced by gland of anal canal +relationship: RO:0003001 UBERON:0004760 ! produced by gland of anal canal + [Term] id: UBERON:0013232 name: serous acinus +def: "The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] +xref: FMA:86279 is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0000409 ! part of serous gland @@ -43271,6 +66927,13 @@ relationship: RO:0002473 CL:0000313 ! serous secreting cell [Term] id: UBERON:0013411 name: cranial cavity +def: "Anatomical cavity that is the lumen of the skull and contains the brain." [UBERON:cjm] +xref: FMA:9644 +xref: MA:0003061 +xref: NCIT:C77638 +xref: neuronames:2806 +xref: SCTID:264452006 +xref: Wikipedia:Cranial_cavity is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0003129 ! skull @@ -43280,15 +66943,99 @@ relationship: RO:0002572 UBERON:0003129 ! skull [Term] id: UBERON:0013479 name: lung endothelium +def: "A blood vessel endothelium that is part of a lung [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004128 +xref: CALOHA:TS-0573 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0004638 ! blood vessel endothelium intersection_of: BFO:0000050 UBERON:0002048 ! part of lung +[Term] +id: UBERON:0013501 +name: cloacal sphincter +def: "A sphincter muscle that is part of a cloaca." [OBOL:automatic] +comment: the muscles of the cloacal sphincter specialise into the perineal muscles in mammals (Gegenbaur, 1883; Popowsky, 1899; Nishi, 1938). +xref: NCIT:C34129 +is_a: UBERON:0004590 ! sphincter muscle +is_a: UBERON:0014783 ! cloacal muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0013503 +name: caudal vertebra cartilage element +def: "A caudal vertebra endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] +xref: EHDAA2:0000260 +xref: EMAPA:18044 +is_a: UBERON:0011094 ! vertebra cartilage element +is_a: UBERON:0018142 ! caudal vertebra endochondral element +is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue +relationship: RO:0002202 UBERON:0013504 ! caudal vertebra pre-cartilage condensation +relationship: RO:0002387 UBERON:0001095 ! caudal vertebra + +[Term] +id: UBERON:0013504 +name: caudal vertebra pre-cartilage condensation +def: "A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] +xref: EMAPA:18045 +is_a: UBERON:0011095 ! vertebra pre-cartilage condensation +is_a: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: RO:0002473 UBERON:0005866 ! pre-cartilage condensation + +[Term] +id: UBERON:0013505 +name: cervical vertebra cartilage element +def: "A cervical vertebra endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] +xref: EHDAA2:0000240 +is_a: UBERON:0003601 ! neck cartilage +is_a: UBERON:0011094 ! vertebra cartilage element +is_a: UBERON:0015007 ! cervical vertebra endochondral element +is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue +relationship: RO:0002202 UBERON:0013506 ! cervical vertebra pre-cartilage condensation +relationship: RO:0002387 UBERON:0002413 ! cervical vertebra + +[Term] +id: UBERON:0013506 +name: cervical vertebra pre-cartilage condensation +def: "A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] +is_a: UBERON:0011095 ! vertebra pre-cartilage condensation +is_a: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: RO:0002473 UBERON:0005866 ! pre-cartilage condensation + +[Term] +id: UBERON:0013507 +name: thoracic vertebra cartilage element +def: "A thoracic vertebra endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] +xref: EHDAA2:0002014 +is_a: UBERON:0011094 ! vertebra cartilage element +is_a: UBERON:0015008 ! thoracic vertebra endochondral element +is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue +relationship: RO:0002202 UBERON:0013508 ! thoracic vertebra pre-cartilage condensation +relationship: RO:0002387 UBERON:0002347 ! thoracic vertebra + +[Term] +id: UBERON:0013508 +name: thoracic vertebra pre-cartilage condensation +def: "A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] +is_a: UBERON:0011095 ! vertebra pre-cartilage condensation +is_a: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: RO:0002473 UBERON:0005866 ! pre-cartilage condensation + [Term] id: UBERON:0013514 name: space surrounding organism +def: "The space that surrounds an organism." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002221 UBERON:0000468 ! multicellular organism @@ -43306,15 +67053,33 @@ relationship: subdivision_of UBERON:0000025 ! tube [Term] id: UBERON:0013525 name: stomach lumen +def: "The anatomical space that is enclosed by a stomach." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:18395 +xref: FMA:14585 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000945 ! stomach relationship: BFO:0000050 UBERON:0011565 ! part of lumen of gastrointestinal system relationship: RO:0002572 UBERON:0000945 ! stomach +[Term] +id: UBERON:0013636 +name: epithelium of intestinal villus +def: "An epithelium that is part of a intestinal villus." [OBOL:automatic] +xref: FMA:63587 +is_a: UBERON:0001902 ! epithelium of small intestine +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus +relationship: BFO:0000050 UBERON:0001213 ! part of intestinal villus +relationship: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine + [Term] id: UBERON:0013685 name: foramen of skull +def: "Anatomical space that is an opening in a bone of the skull." [http://orcid.org/0000-0002-6601-2165, TAO:curator] +xref: FMA:53165 +xref: SCTID:276742007 +xref: Wikipedia:Foramina_of_the_skull is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0005744 ! bone foramen intersection_of: BFO:0000050 UBERON:0003129 ! part of skull @@ -43323,25 +67088,51 @@ relationship: BFO:0000050 UBERON:0003129 ! part of skull [Term] id: UBERON:0013686 name: anatomical conduit space +def: "An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]." [FMA:9338, http://orcid.org/0000-0002-6601-2165] +xref: FMA:9338 is_a: UBERON:0000464 ! anatomical space relationship: RO:0002176 UBERON:0000464 {cardinality="2"} ! anatomical space relationship: RO:0002572 UBERON:0004111 ! anatomical conduit -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0013694 name: brain endothelium +def: "Vascular endothelium found in blood vessels of the blood-brain-barrier." [CALOHA:TS-0092] +xref: BTO:0001852 +xref: BTO:0003248 +xref: CALOHA:TS-0092 is_a: UBERON:0001986 ! endothelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain +[Term] +id: UBERON:0013695 +name: colon endothelium +def: "Vascular endothelium found in colon blood vessels." [CALOHA:TS-0162] +xref: CALOHA:TS-0162 +is_a: UBERON:0000397 ! colonic epithelium +is_a: UBERON:0001986 ! endothelium +intersection_of: UBERON:0001986 ! endothelium +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0013697 +name: exocrine pancreas epithelium +def: "Epithelium lining the exocrine pancreas." [CALOHA:TS-2108] +xref: CALOHA:TS-2108 +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas + [Term] id: UBERON:0013700 name: axial musculature +def: "Musculature of the head and neck, spine, and ribs." [HP:0003327] +xref: EHDAA2:0000159 +xref: EMAPA:18166 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0013701 ! part of main body axis @@ -43352,18 +67143,26 @@ relationship: RO:0002371 UBERON:0005944 ! axial skeleton plus cranial skeleton [Term] id: UBERON:0013701 name: main body axis +def: "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0013702 name: body proper +def: "The region of the organism associated with the visceral organs." [AEO:0000103] +xref: AEO:0000103 +xref: BTO:0001489 +xref: FMA:231424 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0013701 ! part of main body axis [Term] id: UBERON:0013704 name: notochordal canal +def: "A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily." [http://medical-dictionary.thefreedictionary.com/notochordal+canal] +xref: FMA:293127 +xref: NCIT:C34230 is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0004111 ! anatomical conduit @@ -43373,6 +67172,8 @@ relationship: BFO:0000050 UBERON:0006268 ! part of notochordal process [Term] id: UBERON:0013727 name: notochordal fluid +def: "Fluid contained within the notochordal canal." [http://animaldiversity.org/accounts/Latimeria_chalumnae/, http://orcid.org/0000-0002-6601-2165] +comment: Distinct feature of coelocanths is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid intersection_of: BFO:0000050 UBERON:0036242 ! part of post-embryonic notochord @@ -43383,6 +67184,8 @@ relationship: RO:0001025 UBERON:0013704 ! notochordal canal [Term] id: UBERON:0013754 name: integumentary system layer +def: "An organ component layer that is part of a integumental system." [OBOL:automatic] +xref: SCTID:314820002 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system @@ -43391,6 +67194,8 @@ relationship: BFO:0000050 UBERON:0002416 ! part of integumental system [Term] id: UBERON:0013755 name: arterial blood +def: "A blood that is part of a artery." [OBOL:automatic] +xref: FMA:83066 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: RO:0001025 UBERON:0001637 ! artery @@ -43399,6 +67204,8 @@ relationship: RO:0001025 UBERON:0001637 ! artery [Term] id: UBERON:0013756 name: venous blood +def: "A blood that is part of a vein." [OBOL:automatic] +xref: FMA:83067 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: RO:0001025 UBERON:0001638 ! vein @@ -43407,6 +67214,9 @@ relationship: RO:0001025 UBERON:0001638 ! vein [Term] id: UBERON:0013757 name: capillary blood +def: "A blood that is part of a capillary." [OBOL:automatic] +xref: FMA:263901 +xref: NCIT:C32212 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: RO:0001025 UBERON:0001982 ! capillary @@ -43415,6 +67225,8 @@ relationship: RO:0001025 UBERON:0001982 ! capillary [Term] id: UBERON:0013765 name: digestive system element +def: "Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements." [http://orcid.org/0000-0002-6601-2165] +xref: SCTID:272627002 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system @@ -43423,11 +67235,19 @@ relationship: BFO:0000050 UBERON:0001007 ! part of digestive system [Term] id: UBERON:0013768 name: great vessel of heart +def: "Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart." [Wikipedia:Great_vessels] +comment: Groupings may vary - typically pulmonary vessels and aorta and vena cavae +xref: EMAPA:36460 +xref: SCTID:304066000 +xref: Wikipedia:Great_vessels is_a: UBERON:0001981 ! blood vessel [Term] id: UBERON:0014387 name: mesenchyme derived from neural crest +def: "Mesenchyme that develops_from the neural crest[Automatically generated definition]." [https://github.com/obophenotype/uberon/issues/248, OBOL:automatic] +xref: EMAPA:32735 +xref: FMA:293883 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0003104 ! mesenchyme @@ -43436,6 +67256,7 @@ intersection_of: RO:0002202 UBERON:0002342 ! neural crest [Term] id: UBERON:0014398 name: respiratory muscle +def: "Muscle that is part of the respiratory system." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0003831 ! respiratory system muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: RO:0002216 GO:0007585 ! capable of part of respiratory gaseous exchange by respiratory system @@ -43445,15 +67266,30 @@ relationship: RO:0002473 UBERON:0001134 ! skeletal muscle tissue [Term] id: UBERON:0014399 name: sinusoidal space +def: "An anatomical space that is enclosed by a sinusoid." [OBOL:automatic] +xref: FMA:63133 is_a: UBERON:0010161 ! lumen of blood vessel intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0003909 ! sinusoid relationship: BFO:0000050 UBERON:0003909 ! part of sinusoid relationship: RO:0002572 UBERON:0003909 ! sinusoid +[Term] +id: UBERON:0014400 +name: hepatic sinusoidal space +def: "A sinusoidal space that is part of a hepatic sinusoid." [OBOL:automatic] +xref: FMA:262090 +is_a: UBERON:0014399 ! sinusoidal space +intersection_of: UBERON:0014399 ! sinusoidal space +intersection_of: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid +relationship: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid + [Term] id: UBERON:0014402 name: sex-specific anatomical structure +def: "A part of the body present only in a specific gender." [AEO:0000174, AEO:JB] +xref: AEO:0000174 +xref: WBbt:0005752 is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002353 GO:0007548 ! output of sex differentiation @@ -43462,6 +67298,8 @@ relationship: RO:0002353 GO:0007548 ! output of sex differentiation [Term] id: UBERON:0014404 name: female anatomical structure +def: "A part of the body present only in females." [AEO:0000176, AEO:JB] +xref: AEO:0000176 is_a: UBERON:0014402 ! sex-specific anatomical structure intersection_of: UBERON:0014402 ! sex-specific anatomical structure intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism @@ -43470,6 +67308,9 @@ relationship: BFO:0000050 UBERON:0003100 ! part of female organism [Term] id: UBERON:0014454 name: visceral abdominal adipose tissue +def: "Subcutaneous adipose tissue that is located in the peritoneal cavity." [CALOHA:paula, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/259, MGI:csmith] +xref: BTO:0004041 +xref: CALOHA:TS-2405 is_a: UBERON:0007808 ! adipose tissue of abdominal region intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -43481,6 +67322,8 @@ relationship: RO:0002007 UBERON:0002075 ! bounding layer of viscus [Term] id: UBERON:0014455 name: subcutaneous abdominal adipose tissue +def: "Subcutaneous adipose tissue that is located in the abdominal region." [CALOHA:paula, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/259, MGI:csmith] +xref: CALOHA:TS-2406 is_a: UBERON:0002190 ! subcutaneous adipose tissue is_a: UBERON:0007808 ! adipose tissue of abdominal region intersection_of: UBERON:0001013 ! adipose tissue @@ -43490,50 +67333,91 @@ intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis [Term] id: UBERON:0014477 name: thoracic skeleton +def: "Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Rib_cage] +xref: EHDAA2:0002013 +xref: FMA:77169 +xref: Wikipedia:Thoracic_skeleton is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014610 name: thoracic spinal cord ventral horn +def: "A ventral horn of spinal cord that is part of a thoracic spinal cord." [OBOL:automatic] +xref: BIRNLEX:1410 +xref: SCTID:367876000 is_a: UBERON:0002257 ! ventral horn of spinal cord intersection_of: UBERON:0002257 ! ventral horn of spinal cord intersection_of: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord relationship: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014613 name: cervical spinal cord gray matter +def: "A gray matter of spinal cord that is part of a cervical spinal cord." [OBOL:automatic] +xref: BIRNLEX:1521 +xref: SCTID:362438009 is_a: UBERON:0002315 ! gray matter of spinal cord intersection_of: UBERON:0002315 ! gray matter of spinal cord intersection_of: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord relationship: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014621 name: cervical spinal cord ventral horn +def: "A ventral horn of spinal cord that is part of a cervical spinal cord." [OBOL:automatic] +xref: BIRNLEX:1680 +xref: SCTID:174363005 is_a: UBERON:0002257 ! ventral horn of spinal cord intersection_of: UBERON:0002257 ! ventral horn of spinal cord intersection_of: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord relationship: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014636 name: thoracic spinal cord gray matter +def: "A gray matter of spinal cord that is part of a thoracic spinal cord." [OBOL:automatic] +xref: BIRNLEX:980 +xref: SCTID:362441000 is_a: UBERON:0002315 ! gray matter of spinal cord intersection_of: UBERON:0002315 ! gray matter of spinal cord intersection_of: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord relationship: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0014702 +name: frontonasal process epithelium +def: "An epithelium that is part of a frontonasal prominence." [OBOL:automatic] +xref: EHDAA2:0004108 +xref: EMAPA:32918 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence +relationship: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence +relationship: RO:0002202 UBERON:0000076 ! external ectoderm + +[Term] +id: UBERON:0014703 +name: anal membrane ectodermal component +def: "A unilaminar epithelium that develops_from a ectoderm and is part of a anal region." [OBOL:automatic] +xref: EHDAA2:0004019 +xref: EMAPA:25040 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000490 ! unilaminar epithelium +intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region +intersection_of: RO:0002202 UBERON:0000924 ! ectoderm +relationship: BFO:0000050 UBERON:0001353 ! part of anal region [Term] id: UBERON:0014704 name: pleuroperitoneal canal lumen +def: "An anatomical space that is enclosed by a pleuroperitoneal canal." [OBOL:automatic] +xref: EHDAA2:0004736 +xref: EMAPA:25034 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0006279 ! pleuroperitoneal canal @@ -43543,26 +67427,42 @@ relationship: RO:0002572 UBERON:0006279 ! pleuroperitoneal canal [Term] id: UBERON:0014716 name: interlobular duct +def: "A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory." [ncithesaurus:Interlobular_Duct] +xref: NCIT:C32828 +xref: UMLS:C1512857 +xref: Wikipedia:Interlobular_ducts is_a: UBERON:0035050 ! excretory duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue intersection_of: RO:0002170 UBERON:0009911 ! lobule relationship: BFO:0000050 UBERON:0002384 ! part of connective tissue relationship: RO:0002170 UBERON:0009911 ! lobule -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0014717 +name: mucous acinus +def: "The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] +xref: FMA:86278 +is_a: UBERON:0011858 ! acinus of exocrine gland +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: BFO:0000050 UBERON:0000414 ! part of mucous gland +relationship: BFO:0000050 UBERON:0000414 ! part of mucous gland +relationship: RO:0002473 CL:0000319 ! mucus secreting cell [Term] id: UBERON:0014719 name: intralobular duct +def: "A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular." [http://www.siumed.edu/~dking2/intro/glands.htm] +xref: SCTID:205214009 is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0009911 ! part of lobule relationship: BFO:0000050 UBERON:0009911 ! part of lobule -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014720 name: interlobar duct +def: "A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory." [http://www.siumed.edu/~dking2/intro/glands.htm] is_a: UBERON:0035050 ! excretory duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue @@ -43573,6 +67473,9 @@ relationship: RO:0002176 UBERON:0009912 ! anatomical lobe [Term] id: UBERON:0014776 name: midbrain neuromere +def: "A neuromere that is part of the presumptive midbrain." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0004352 +xref: FMA:61997 is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain @@ -43581,14 +67484,29 @@ relationship: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain [Term] id: UBERON:0014777 name: spinal neuromere +def: "A neuromere that is part of the presumptive spinal cord." [http://orcid.org/0000-0002-6601-2165] +xref: TAO:0001332 +xref: ZFA:0001332 is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord +[Term] +id: UBERON:0014783 +name: cloacal muscle +def: "Any muscle organ that is part of a cloaca." [OBOL:automatic] +is_a: UBERON:0001630 ! muscle organ +is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0001630 ! muscle organ +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + [Term] id: UBERON:0014793 name: musculature of pectoral complex +def: "Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin." [OBOL:automatic] +xref: FMA:71296 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex @@ -43597,6 +67515,7 @@ relationship: BFO:0000050 UBERON:0010708 ! part of pectoral complex [Term] id: UBERON:0014794 name: pectoral appendage muscle +def: "Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin)." [OBOL:automatic] is_a: UBERON:0010891 ! pectoral complex muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage @@ -43605,6 +67524,26 @@ relationship: BFO:0000050 UBERON:0007269 ! part of pectoral appendage musculatur [Term] id: UBERON:0014892 name: skeletal muscle organ, vertebrate +def: "A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles)." [GOC:dos] +xref: AAO:0011099 +xref: BTO:0001103 +xref: CALOHA:TS-0933 +xref: EFO:0000888 +xref: EHDAA:5035 +xref: EHDAA:5043 +xref: EHDAA:5978 +xref: EHDAA:5984 +xref: EMAPA:35988 +xref: EV:0100377 +xref: GAID:141 +xref: MA:0003148 +xref: MAT:0000302 +xref: MESH:D018482 +xref: MIAA:0000302 +xref: TAO:0005277 +xref: VHOG:0000319 +xref: XAO:0000174 +xref: ZFA:0005277 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: RO:0002103 CL:0000100 ! motor neuron @@ -43617,11 +67556,14 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002202 UBERON:0003082 ! myotome relationship: RO:0002219 UBERON:0011899 ! epimysium relationship: RO:0002473 UBERON:0001134 ! skeletal muscle tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014903 name: primordial vasculature +def: "A portion of tissue that will develop into vasculature." [ZFA:0005076, ZFA:curator] +xref: EFO:0003708 +xref: TAO:0005076 +xref: ZFA:0005076 is_a: UBERON:0001048 ! primordium intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0002049 ! vasculature @@ -43631,18 +67573,64 @@ relationship: RO:0002387 UBERON:0002049 ! vasculature [Term] id: UBERON:0014907 name: intersomitic vessel +def: "One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites." [MGI:anna] +xref: EFO:0003664 +xref: TAO:0001285 +xref: XAO:0004075 +xref: ZFA:0001285 is_a: UBERON:0001981 ! blood vessel relationship: RO:0002202 UBERON:0005805 ! dorsal aorta +[Term] +id: UBERON:0015007 +name: cervical vertebra endochondral element +def: "A vertebral endochondral element in the cervical region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0005174 ! dorsal region element +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: BFO:0000050 UBERON:0006072 ! part of cervical region of vertebral column +union_of: UBERON:0002413 ! cervical vertebra +union_of: UBERON:0013505 ! cervical vertebra cartilage element +union_of: UBERON:0013506 ! cervical vertebra pre-cartilage condensation +relationship: BFO:0000050 UBERON:0006072 ! part of cervical region of vertebral column + +[Term] +id: UBERON:0015008 +name: thoracic vertebra endochondral element +def: "A vertebral endochondral element in the thoracic region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0005174 ! dorsal region element +is_a: UBERON:0005181 ! thoracic segment organ +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: BFO:0000050 UBERON:0006073 ! part of thoracic region of vertebral column +union_of: UBERON:0002347 ! thoracic vertebra +union_of: UBERON:0013507 ! thoracic vertebra cartilage element +union_of: UBERON:0013508 ! thoracic vertebra pre-cartilage condensation +relationship: BFO:0000050 UBERON:0006073 ! part of thoracic region of vertebral column + +[Term] +id: UBERON:0015060 +name: sphenoid endochondral element +def: "A sphenoid bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010363 ! endochondral element +union_of: UBERON:0001677 ! sphenoid bone +union_of: UBERON:0009191 ! sphenoid bone pre-cartilage condensation +union_of: UBERON:0009193 ! sphenoid cartilage element +relationship: BFO:0000050 UBERON:0011156 ! part of facial skeleton + [Term] id: UBERON:0015128 name: subepicardial layer of epicardium +xref: FMA:83105 is_a: UBERON:0007188 ! mesothelium of serous pericardium relationship: BFO:0000050 UBERON:0002348 ! part of epicardium [Term] id: UBERON:0015129 name: epicardial fat +def: "Visceral intrapericardial fat contiguous with the myocardial surface." [DOI:10.5935/abc.20130138] +xref: FMA:9871 is_a: UBERON:0003837 ! thoracic segment connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0035814 ! pericardial fat @@ -43658,6 +67646,7 @@ relationship: RO:0002473 CL:1000309 ! epicardial adipocyte [Term] id: UBERON:0015152 name: gland of ocular region +def: "A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/614] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0004088 ! part of orbital region @@ -43666,6 +67655,7 @@ relationship: BFO:0000050 UBERON:0035639 ! part of ocular adnexa [Term] id: UBERON:0015165 name: multi-unit eye +def: "An eye consisting of multiple light-sensing organs." [http://orcid.org/0000-0002-6601-2165, PMID:21062451] is_a: UBERON:0000970 ! eye intersection_of: UBERON:0000970 ! eye intersection_of: RO:0002473 UBERON:0000020 ! sense organ @@ -43674,6 +67664,10 @@ relationship: RO:0002473 UBERON:0000020 ! sense organ [Term] id: UBERON:0015178 name: somite border +def: "A region of somite adjacent to presomitic mesoderm." [http://orcid.org/0000-0002-6601-2165] +xref: TAO:0001462 +xref: XAO:0004074 +xref: ZFA:0001462 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: BFO:0000050 UBERON:0002329 ! part of somite @@ -43684,6 +67678,8 @@ relationship: RO:0002220 UBERON:0003059 ! adjacent to presomitic mesoderm [Term] id: UBERON:0015179 name: somite boundary epithelium +def: "Epithelium located in the intersomitic region." [XAO:0004077, XAO:EJS] +xref: XAO:0004077 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0015178 ! part of somite border @@ -43692,11 +67688,15 @@ relationship: BFO:0000050 UBERON:0015178 ! part of somite border [Term] id: UBERON:0015203 name: non-connected functional system +def: "An anatomical group whose component structures share a common function." [AEO:0000093, AEO:JB, FBbt:00007278, FBC:DOS] +xref: AEO:0000093 is_a: UBERON:0034923 ! disconnected anatomical group [Term] id: UBERON:0015204 name: glandular system +def: "A non-connected functional system that is composed primarily of a gland." [OBOL:automatic] +xref: EHDAA2:0002223 is_a: UBERON:0015203 ! non-connected functional system intersection_of: UBERON:0015203 ! non-connected functional system intersection_of: RO:0002473 UBERON:0002530 ! gland @@ -43705,6 +67705,7 @@ relationship: RO:0002473 UBERON:0002530 ! gland [Term] id: UBERON:0015212 name: lateral structure +def: "Any structure that is placed on one side of the left-right axis of a bilaterian." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: BSPO:0000126 UBERON:0000465 ! material anatomical entity @@ -43714,13 +67715,38 @@ relationship: RO:0002160 NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0015228 name: circulatory organ +def: "A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0003103 ! compound organ relationship: BFO:0000050 UBERON:0001009 ! part of circulatory system relationship: RO:0000086 PATO:0001690 +[Term] +id: UBERON:0015280 +name: pancreas left lobe +def: "A pancreatic lobule that is in_the_left_side_of a exocrine pancreas." [OBOL:automatic] +xref: MA:0000722 +is_a: UBERON:0007324 ! pancreatic lobule +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0007324 ! pancreatic lobule +intersection_of: BSPO:0000120 UBERON:0000017 ! exocrine pancreas +relationship: BSPO:0000120 UBERON:0000017 ! exocrine pancreas + +[Term] +id: UBERON:0015281 +name: pancreas right lobe +def: "A pancreatic lobule that is in_the_right_side_of a exocrine pancreas." [OBOL:automatic] +xref: MA:0000723 +is_a: UBERON:0007324 ! pancreatic lobule +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0007324 ! pancreatic lobule +intersection_of: BSPO:0000121 UBERON:0000017 ! exocrine pancreas +relationship: BSPO:0000121 UBERON:0000017 ! exocrine pancreas + [Term] id: UBERON:0015329 name: respiratory system basement membrane +def: "A basement membrane of epithelium that is part of a respiratory system." [OBOL:automatic] +xref: MA:0001815 is_a: UBERON:0005769 ! basement membrane of epithelium intersection_of: UBERON:0005769 ! basement membrane of epithelium intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -43729,26 +67755,105 @@ relationship: BFO:0000050 UBERON:0003570 ! part of respiratory system connective [Term] id: UBERON:0015410 name: heart plus pericardium +xref: MA:0002449 is_a: UBERON:0005178 ! thoracic cavity element relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0015480 +name: proper hepatic artery +def: "The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery." [Wikipedia:Hepatic_artery_proper] +xref: FMA:14772 +xref: MA:0003095 +xref: SCTID:244262006 +xref: Wikipedia:Hepatic_artery_proper +is_a: UBERON:0001193 ! hepatic artery +relationship: RO:0002252 UBERON:0005436 ! common hepatic artery + +[Term] +id: UBERON:0015481 +name: left hepatic artery +def: "A hepatic artery that is part of a left lobe of liver." [OBOL:automatic] +xref: FMA:14779 +xref: MA:0003096 +is_a: UBERON:0001193 ! hepatic artery +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001193 ! hepatic artery +intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: RO:0002170 UBERON:0015480 ! proper hepatic artery + +[Term] +id: UBERON:0015482 +name: right hepatic artery +def: "A hepatic artery that is part of a right lobe of liver." [OBOL:automatic] +xref: FMA:14778 +xref: MA:0003097 +is_a: UBERON:0001193 ! hepatic artery +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001193 ! hepatic artery +intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: RO:0002170 UBERON:0015480 ! proper hepatic artery + +[Term] +id: UBERON:0015485 +name: choledocho-duodenal junction +def: "Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla." [http://medical-dictionary.thefreedictionary.com/choledochoduodenal+junction] +xref: MA:0003108 +is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0002114 ! duodenum +intersection_of: RO:0002176 UBERON:0002394 ! bile duct +relationship: RO:0002176 UBERON:0002114 ! duodenum +relationship: RO:0002176 UBERON:0002394 ! bile duct + +[Term] +id: UBERON:0015716 +name: anal canal epithelium +def: "An epithelium that is part of a anal canal." [OBOL:automatic] +xref: EMAPA:18835 +xref: FMA:17511 +is_a: UBERON:0001278 ! epithelium of large intestine +is_a: UBERON:0014703 ! anal membrane ectodermal component +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal [Term] id: UBERON:0015757 name: heterogeneous tissue +xref: FMA:62798 is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0015783 name: smooth muscle layer in fatty layer of subcutaneous tissue +def: "A smooth muscle tissue that is part of a hypodermis." [OBOL:automatic] +xref: FMA:77862 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: BFO:0000050 UBERON:0002072 ! part of hypodermis +[Term] +id: UBERON:0015796 +name: liver blood vessel +def: "A blood vessel that is part of a liver." [OBOL:automatic] +xref: EMAPA:35498 +xref: MA:0003137 +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0003497 ! abdomen blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: UBERON:0015808 name: eye epithelium +def: "An epithelium that is part of a camera-type eye." [OBOL:automatic] +xref: EMAPA:35957 +xref: MA:0003162 is_a: UBERON:0007625 ! pigment epithelium of eye is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium @@ -43758,23 +67863,41 @@ relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye [Term] id: UBERON:0015833 name: foregut epithelium +def: "An epithelium that is part of a foregut." [OBOL:automatic] +xref: EMAPA:32922 +xref: MA:0003204 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut relationship: BFO:0000050 UBERON:0001041 ! part of foregut +[Term] +id: UBERON:0015834 +name: duodenum lamina propria +def: "A lamina propria that is part of a duodenum." [OBOL:automatic] +xref: EMAPA:27255 +xref: FMA:15972 +xref: MA:0003209 +is_a: UBERON:0001238 ! lamina propria of small intestine +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0008342 ! part of intestinal villus of duodenum + [Term] id: UBERON:0016405 name: pulmonary capillary +def: "A capillary that is part of a lung." [OBOL:automatic] +xref: FMA:14121 is_a: UBERON:0003512 ! lung blood vessel is_a: UBERON:0003526 ! respiratory system capillary intersection_of: UBERON:0001982 ! capillary intersection_of: BFO:0000050 UBERON:0002048 ! part of lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0016458 name: esophageal hiatus +def: "A hole in the diaphragm through which the esophagus passes." [HP:0002036] +xref: FMA:58289 is_a: UBERON:0000161 ! orifice intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0001103 ! part of diaphragm @@ -43782,9 +67905,28 @@ intersection_of: RO:0002570 UBERON:0001043 ! esophagus relationship: BFO:0000050 UBERON:0001103 ! part of diaphragm relationship: RO:0002570 UBERON:0001043 ! esophagus +[Term] +id: UBERON:0016478 +name: liver stroma +def: "A stroma that is part of a liver." [OBOL:automatic] +xref: FMA:17553 +is_a: UBERON:0003891 ! stroma +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0003891 ! stroma +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: UBERON:0016490 name: auditory system +def: "Is the sensory system for the sense of hearing." [NLXANAT:090817] +xref: EMAPA:36002 +xref: FMA:7192 +xref: MA:0002443 +xref: NCIT:C12889 +xref: neuronames:2888 +xref: NLXANAT:090817 +xref: Wikipedia:Auditory_system is_a: UBERON:0007037 ! mechanosensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: RO:0002215 GO:0007605 ! capable of sensory perception of sound @@ -43794,14 +67936,31 @@ relationship: RO:0002215 GO:0007605 ! capable of sensory perception of sound [Term] id: UBERON:0016509 name: cavity of right ventricle +def: "Luminal space of the right ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:26047 +xref: FMA:9291 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002080 ! heart right ventricle relationship: RO:0002572 UBERON:0002080 ! heart right ventricle +[Term] +id: UBERON:0016512 +name: lumen of duodenum +def: "An anatomical space that is part of a duodenum." [OBOL:automatic] +xref: EMAPA:19080 +xref: FMA:14589 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + [Term] id: UBERON:0016513 name: cavity of left atrium +def: "Luminal space of the left atrium of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:26011 +xref: FMA:9465 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002079 ! left cardiac atrium @@ -43810,6 +67969,9 @@ relationship: RO:0002572 UBERON:0002079 ! left cardiac atrium [Term] id: UBERON:0016514 name: cavity of left ventricle +def: "Luminal space of the left ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:26038 +xref: FMA:9466 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002084 ! heart left ventricle @@ -43818,6 +67980,9 @@ relationship: RO:0002572 UBERON:0002084 ! heart left ventricle [Term] id: UBERON:0016522 name: cavity of right atrium +def: "Luminal space of the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:26020 +xref: FMA:11359 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002078 ! right cardiac atrium @@ -43826,6 +67991,9 @@ relationship: RO:0002572 UBERON:0002078 ! right cardiac atrium [Term] id: UBERON:0016545 name: pharyngeal ectoderm +def: "The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches." [http://orcid.org/0000-0002-6601-2165, PMID:23020903] +xref: TAO:0001379 +xref: ZFA:0001379 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003351 ! pharyngeal epithelium is_a: UBERON:0005291 ! embryonic tissue @@ -43837,6 +68005,8 @@ relationship: BFO:0000050 UBERON:0000076 ! part of external ectoderm [Term] id: UBERON:0016548 name: central nervous system gray matter layer +def: "A layer of of the central nervous system that is part of gray matter." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:83142 is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: RO:0002473 UBERON:0002020 ! gray matter @@ -43848,18 +68018,60 @@ name: spinal cord column is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord +[Term] +id: UBERON:0016552 +name: phlegm +def: "Mucus produced in the respiratory tract." [http://orcid.org/0000-0002-6601-2165] +xref: NCIT:C93171 +xref: UMLS:C0225378 +is_a: UBERON:0000912 ! mucus +intersection_of: UBERON:0000912 ! mucus +intersection_of: RO:0003001 UBERON:0000065 ! produced by respiratory tract +relationship: RO:0003001 UBERON:0000065 ! produced by respiratory tract + +[Term] +id: UBERON:0016553 +name: respiratory system mucus +def: "Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm)." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Nasal_mucus#Respiratory_system] +is_a: UBERON:0000912 ! mucus +intersection_of: UBERON:0000912 ! mucus +intersection_of: RO:0003001 UBERON:0004785 ! produced by respiratory system mucosa +relationship: RO:0003001 UBERON:0004785 ! produced by respiratory system mucosa + +[Term] +id: UBERON:0016566 +name: pit +def: "An roughly circular indentation in a surface." [AEO:0000204, AEO:JB] +xref: AEO:0000204 +is_a: UBERON:0036215 ! anatomical surface region + [Term] id: UBERON:0016570 name: lamina of gray matter of spinal cord +xref: FMA:68861 +xref: http://neurolex.org/wiki/Category\:Rexed_spinal_cord_parcellation_scheme_region +xref: Wikipedia:Rexed_laminae is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: BFO:0000050 UBERON:0002315 ! part of gray matter of spinal cord relationship: BFO:0000050 UBERON:0002315 ! part of gray matter of spinal cord +[Term] +id: UBERON:0016854 +name: dorsal part of optic cup +def: "The dorsal region of the optic cup that gives rise to the dorsal part of the retina." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0000481 ! multi-tissue structure +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000481 ! multi-tissue structure +intersection_of: BSPO:0015101 UBERON:0003072 ! optic cup +relationship: BFO:0000050 UBERON:0003072 ! part of optic cup +relationship: BSPO:0015101 UBERON:0003072 ! optic cup + [Term] id: UBERON:0016879 name: future central nervous system +def: "Primordium that develops into the central nervous system." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001017 ! central nervous system @@ -43871,15 +68083,41 @@ relationship: RO:0002387 UBERON:0001017 ! central nervous system [Term] id: UBERON:0016880 name: future nervous system +def: "Primordium that develops into the nervous system." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000477 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001016 ! nervous system relationship: RO:0002387 UBERON:0001016 ! nervous system relationship: RO:0002496 UBERON:0000111 ! organogenesis stage +[Term] +id: UBERON:0016885 +name: epithelium of terminal part of digestive tract +def: "Epithelium lining the distalmost portion of the digestive tract." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0005445 +xref: WBbt:0005800 +is_a: UBERON:0003929 ! digestive tract epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract +relationship: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract + +[Term] +id: UBERON:0016886 +name: muscle tissue of terminal part of digestive tract +def: "Any muscle tissue of the distalmost portion of the digestive tract." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0002385 ! muscle tissue +intersection_of: UBERON:0002385 ! muscle tissue +intersection_of: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract +relationship: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract + [Term] id: UBERON:0016887 name: entire extraembryonic component +def: "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism." [AEO:0000195, AEO:JB] +xref: AEO:0000195 +xref: EHDAA2:0000003 +xref: EMAPA:16042 is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0004716 ! part of conceptus relationship: RO:0002220 UBERON:0002050 ! adjacent to embryonic structure @@ -43888,11 +68126,15 @@ relationship: RO:0002491 UBERON:0000068 ! embryo stage [Term] id: UBERON:0016888 name: transitional anatomical structure +def: "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development." [AEO:0000132, AEO:JB] +xref: AEO:0000132 is_a: UBERON:0005423 ! developing anatomical structure [Term] id: UBERON:0017650 name: developing mesenchymal structure +def: "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure." [AEO:0001016, AEO:JB] +xref: AEO:0001016 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: RO:0002473 UBERON:0003104 ! mesenchyme @@ -43901,30 +68143,94 @@ relationship: RO:0002473 UBERON:0003104 ! mesenchyme [Term] id: UBERON:0017672 name: abdominal viscera +def: "A viscus that is part of a abdomen." [OBOL:automatic] +xref: FMA:32413 +xref: FMA:67355 is_a: UBERON:0002075 ! viscus is_a: UBERON:0005172 ! abdomen element intersection_of: UBERON:0002075 ! viscus intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen +[Term] +id: UBERON:0018111 +name: muscle layer of rectum +def: "A muscle layer that is part of the rectum." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:15035 +is_a: UBERON:0011198 ! muscle layer of large intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + +[Term] +id: UBERON:0018112 +name: rectum smooth muscle tissue +def: "Any portion of smooth muscle tissue that is part of the rectum." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0004220 ! large intestine smooth muscle +is_a: UBERON:0004231 ! anal region smooth muscle +is_a: UBERON:0016886 ! muscle tissue of terminal part of digestive tract +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + [Term] id: UBERON:0018135 name: fibrocollagenous connective tissue +xref: FMA:83521 is_a: UBERON:0011824 ! fibrous connective tissue intersection_of: UBERON:0011824 ! fibrous connective tissue intersection_of: RO:0000086 PATO:0002462 relationship: RO:0000086 PATO:0002462 +[Term] +id: UBERON:0018142 +name: caudal vertebra endochondral element +def: "Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx)." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0005174 ! dorsal region element +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: BFO:0000050 UBERON:0006076 ! part of caudal region of vertebral column +union_of: UBERON:0001095 ! caudal vertebra +union_of: UBERON:0013503 ! caudal vertebra cartilage element +union_of: UBERON:0013504 ! caudal vertebra pre-cartilage condensation +relationship: BFO:0000050 UBERON:0006076 ! part of caudal region of vertebral column + [Term] id: UBERON:0018150 name: skin of lower lip +def: "A zone of skin that is part of a lower lip." [OBOL:automatic] +xref: FMA:24767 +xref: SCTID:281630002 is_a: UBERON:0001458 ! skin of lip intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001835 ! part of lower lip relationship: BFO:0000050 UBERON:0001835 ! part of lower lip +[Term] +id: UBERON:0018151 +name: skin of upper lip +def: "A zone of skin that is part of a upper lip." [OBOL:automatic] +xref: FMA:24765 +xref: SCTID:281629007 +is_a: UBERON:0001458 ! skin of lip +is_a: UBERON:1000021 ! skin of face +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: BFO:0000050 UBERON:0001834 ! part of upper lip +relationship: BFO:0000050 UBERON:0001834 ! part of upper lip + +[Term] +id: UBERON:0018234 +name: stroma of pancreas +def: "A stroma that is part of a pancreas." [OBOL:automatic] +xref: FMA:63121 +is_a: UBERON:0003891 ! stroma +intersection_of: UBERON:0003891 ! stroma +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: UBERON:0018239 name: rhombomere boundary +def: "A boundary delimiting a rhombomere." [GO:0021654] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction @@ -43935,14 +68241,16 @@ relationship: RO:0002176 UBERON:0001892 ! rhombomere [Term] id: UBERON:0018254 name: skeletal musculature +xref: EHDAA2:0001842 +xref: EMAPA:35578 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0000383 ! part of musculature of body relationship: RO:0002473 UBERON:0014892 ! skeletal muscle organ, vertebrate -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0018257 name: submucosa of digestive tract +def: "Any portion of submucosa that lines the digestive tract." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000009 ! submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract @@ -43951,14 +68259,55 @@ relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: UBERON:0018260 name: layer of muscle tissue +def: "Any organ component layer that consists of muscle tissue." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:45634 +xref: NCIT:C75444 +xref: UMLS:C0225358 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002473 UBERON:0002385 ! muscle tissue relationship: RO:0002473 UBERON:0002385 ! muscle tissue +[Term] +id: UBERON:0018261 +name: muscular coat of digestive tract +def: "A muscular coat that is part of a digestive tract." [OBOL:automatic] +is_a: UBERON:0006660 ! muscular coat +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract +relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract +relationship: RO:0002216 GO:0030432 ! capable of part of peristalsis + +[Term] +id: UBERON:0018415 +name: ethmoid foramen +def: "An bone foramen in the ethmoid bone." [http://orcid.org/0000-0002-6601-2165] +comment: Taxon nodes: In humans, refers to anterior or posterior ethmoid foramina +xref: Wikipedia:Ethmoidal_foramina +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0013685 ! foramen of skull +intersection_of: UBERON:0004111 ! anatomical conduit +intersection_of: BFO:0000050 UBERON:0001679 ! part of ethmoid bone +relationship: BFO:0000050 UBERON:0001679 ! part of ethmoid bone + +[Term] +id: UBERON:0018543 +name: lumen of intestine +def: "The anatomical space within the intestine." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:14586 +xref: TADS:0000495 +xref: WBbt:0005791 +xref: ZFA:0005807 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0000160 ! intestine +relationship: RO:0002572 UBERON:0000160 ! intestine + [Term] id: UBERON:0018544 name: trigeminal nerve muscle +def: "Muscle innervated by the trigeminal nerve (Cranial Nerve V)." [MFMO:0000072] +xref: MFMO:0000072 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: RO:0002005 UBERON:0001645 ! trigeminal nerve @@ -43968,6 +68317,7 @@ relationship: RO:0002202 UBERON:0004362 ! pharyngeal arch 1 [Term] id: UBERON:0018649 name: cardiac muscle tissue of ventricle +xref: FMA:83450 is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -43976,15 +68326,39 @@ relationship: BFO:0000050 UBERON:0001083 ! part of myocardium of ventricle [Term] id: UBERON:0018674 name: heart vasculature +def: "An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart." [ZFA:0005811, ZFA:CVS] +xref: FMA:73747 +xref: ZFA:0005811 is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart +[Term] +id: UBERON:0018692 +name: dorsal side of post-anal tail +is_a: UBERON:0034929 ! external soft tissue zone +intersection_of: UBERON:0034929 ! external soft tissue zone +intersection_of: BSPO:0015101 UBERON:0007812 ! post-anal tail +relationship: BFO:0000050 UBERON:0001137 ! part of dorsum +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BSPO:0015101 UBERON:0007812 ! post-anal tail + +[Term] +id: UBERON:0018707 +name: bladder organ +def: "A membranous sac in animals that serves as the receptacle of a liquid or contains gas." [BTO:0000123] +xref: BTO:0000123 +is_a: UBERON:0000489 ! cavitated compound organ +is_a: UBERON:0009856 ! sac +relationship: RO:0000086 PATO:0002468 +relationship: RO:0001015 UBERON:0000463 ! organism substance + [Term] id: UBERON:0019042 name: reproductive system mucosa +xref: BTO:0002439 is_a: UBERON:0000344 ! mucosa is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000344 ! mucosa @@ -43993,6 +68367,8 @@ intersection_of: BFO:0000050 UBERON:0000990 ! part of reproductive system [Term] id: UBERON:0019143 name: intramuscular adipose tissue +def: "Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes." [BTO:0004043] +xref: BTO:0004043 is_a: UBERON:0001013 ! adipose tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0014892 ! part of skeletal muscle organ, vertebrate @@ -44001,14 +68377,31 @@ relationship: BFO:0000050 UBERON:0014892 ! part of skeletal muscle organ, verteb [Term] id: UBERON:0019189 name: carotid artery endothelium +xref: BTO:0004626 is_a: UBERON:0001917 ! endothelium of artery intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0005396 ! part of carotid artery segment relationship: BFO:0000050 UBERON:0005396 ! part of carotid artery segment +[Term] +id: UBERON:0019190 +name: mucous gland of lung +xref: BTO:0004638 +xref: FMA:13119 +xref: SCTID:88410004 +is_a: UBERON:0000414 ! mucous gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005181 ! thoracic segment organ +is_a: UBERON:0036225 ! respiratory system gland +intersection_of: UBERON:0000414 ! mucous gland +intersection_of: BFO:0000050 UBERON:0002048 ! part of lung +relationship: BFO:0000050 UBERON:0002048 ! part of lung + [Term] id: UBERON:0019204 name: skin epithelium +def: "Any region of epithelium that is part of a skin region." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0004382 is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000014 ! part of zone of skin @@ -44017,6 +68410,8 @@ relationship: BFO:0000050 UBERON:0000014 ! part of zone of skin [Term] id: UBERON:0019207 name: chorioretinal region +def: "The part of the eye that consists of both the retina and the optic choroid." [http://orcid.org/0000-0002-6601-2165, UBERON:drseb] +xref: SCTID:110701000 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -44027,24 +68422,28 @@ relationship: BFO:0000051 UBERON:0001776 ! has part optic choroid [Term] id: UBERON:0019263 name: gray matter of hindbrain +xref: DHBA:10654 +xref: FMA:268630 is_a: UBERON:0003528 ! brain gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0019267 name: gray matter of midbrain +xref: DHBA:10649 +xref: FMA:83913 is_a: UBERON:0003528 ! brain gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: BFO:0000050 UBERON:0001891 ! part of midbrain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0019304 name: sensory organ epithelium +xref: EMAPA:35952 +xref: MA:0003174 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000020 ! part of sense organ @@ -44053,6 +68452,7 @@ relationship: BFO:0000050 UBERON:0000020 ! part of sense organ [Term] id: UBERON:0019319 name: exocrine gland of integumental system +def: "An exocrine gland that is part of a integumental system." [GOC:dos, http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003297 ! gland of integumental system intersection_of: UBERON:0002365 ! exocrine gland @@ -44061,14 +68461,27 @@ intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system [Term] id: UBERON:0022288 name: surface of eyeball +xref: FMA:58315 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: RO:0002007 UBERON:0010230 ! bounding layer of eyeball of camera-type eye relationship: RO:0002007 UBERON:0010230 ! bounding layer of eyeball of camera-type eye +[Term] +id: UBERON:0022292 +name: splenic arteriole +xref: NCIT:C33596 +xref: SCTID:282511007 +is_a: UBERON:0001980 ! arteriole +is_a: UBERON:0003497 ! abdomen blood vessel +intersection_of: UBERON:0001980 ! arteriole +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + [Term] id: UBERON:0022293 name: reproductive gland secretion +def: "A portion of organism substance that is secreted by a reproductive gland." [UBERON:cjm] is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0003937 ! produced by reproductive gland @@ -44077,6 +68490,8 @@ relationship: RO:0003001 UBERON:0003937 ! produced by reproductive gland [Term] id: UBERON:0022303 name: nervous system cell part layer +def: "Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]." [NLX:149357] +xref: NLX:149357 is_a: UBERON:0005162 ! multi cell part structure intersection_of: UBERON:0005162 ! multi cell part structure intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system @@ -44087,6 +68502,8 @@ relationship: RO:0000086 PATO:0002124 [Term] id: UBERON:0022350 name: visceral serous membrane +def: "Serous membrane layer that is adjacent to and lines an organ." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:15860 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -44098,6 +68515,9 @@ relationship: RO:0002220 UBERON:0000062 ! adjacent to organ [Term] id: UBERON:0022351 name: parietal serous membrane +def: "Serous membrane layer that lines to a body cavity." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:15859 +xref: MA:0002448 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -44109,6 +68529,8 @@ relationship: RO:0002220 UBERON:0002553 ! adjacent to anatomical cavity [Term] id: UBERON:0022361 name: lung field +def: "A specific region of the foregut into the area in which the lung will develop." [GOC:dph, GOC:mtg_lung] +xref: SCTID:34922002 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0007688 ! anlage intersection_of: UBERON:0007688 ! anlage @@ -44119,23 +68541,34 @@ relationship: RO:0002387 UBERON:0002048 ! lung [Term] id: UBERON:0034705 name: developing neuroepithelium +def: "An embryonic or larval epithelium that is committed to form part of the nervous system." [AEO:0001008, AEO:JB] +xref: AEO:0001008 +xref: BTO:0000314 +xref: EHDAA2_RETIRED:0004654 +xref: FMA:64807 is_a: UBERON:0000483 ! epithelium relationship: BFO:0000050 UBERON:0001016 ! part of nervous system [Term] id: UBERON:0034706 name: proliferating neuroepithelium +def: "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells." [AEO:0001009] +xref: AEO:0001009 is_a: UBERON:0034705 ! developing neuroepithelium [Term] id: UBERON:0034707 name: differentiating neuroepithelium +def: "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells." [AEO:0001010] +xref: AEO:0001010 is_a: UBERON:0034705 ! developing neuroepithelium relationship: BFO:0000051 CL:0000031 ! has part neuroblast (sensu Vertebrata) [Term] id: UBERON:0034709 name: hindbrain marginal layer +xref: DHBA:12694 +xref: EMAPA:32916 is_a: UBERON:0004062 ! neural tube marginal layer is_a: UBERON:0011215 ! central nervous system cell part cluster intersection_of: UBERON:0004062 ! neural tube marginal layer @@ -44145,6 +68578,8 @@ relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain [Term] id: UBERON:0034710 name: spinal cord ventricular layer +xref: EHDAA2:0001267 +xref: EMAPA:17585 is_a: UBERON:0004060 ! neural tube ventricular layer intersection_of: UBERON:0004060 ! neural tube ventricular layer intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord @@ -44154,40 +68589,48 @@ relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord [Term] id: UBERON:0034713 name: cranial neuron projection bundle +def: "Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain." [http://orcid.org/0000-0002-6601-2165, ISBN:0471888893] is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000033 ! head relationship: extends_fibers_into UBERON:0000955 ! brain relationship: RO:0002160 NCBITaxon:89593 ! Craniata -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0034728 name: autonomic nerve +def: "The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa." [Wikipedia:Autonomic_nerve] +xref: FMA:5866 +xref: MESH:D017776 +xref: SCTID:276145003 +xref: Wikipedia:Autonomic_nerve is_a: UBERON:0011779 ! nerve of head region relationship: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: extends_fibers_into UBERON:0001805 ! autonomic ganglion relationship: RO:0002380 UBERON:0036264 ! zygomaticotemporal nerve -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0034729 name: sympathetic nerve +xref: SCTID:181098007 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system relationship: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system relationship: extends_fibers_into UBERON:0001806 ! sympathetic ganglion -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0034769 name: lymphomyeloid tissue +xref: FMA:79770 +xref: NCIT:C41168 is_a: UBERON:0015757 ! heterogeneous tissue [Term] id: UBERON:0034873 name: bodily gas +def: "Any substance in the body or expelled from the body that is in a gaseous state." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:84580 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0000086 PATO:0001547 @@ -44196,6 +68639,8 @@ relationship: RO:0000086 PATO:0001547 [Term] id: UBERON:0034874 name: air in respiratory system +def: "Any portion of gas located in a part of the respiratory system that is composed primarily of air." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:84581 is_a: UBERON:0034947 ! gas in respiratory system intersection_of: UBERON:0034873 ! bodily gas intersection_of: RO:0001025 UBERON:0001004 ! respiratory system @@ -44205,6 +68650,7 @@ relationship: RO:0002473 CHEBI:25805 [Term] id: UBERON:0034878 name: prechordal mesoderm +def: "The area of axial mesoderm that develops into the prechordal plate." [MGI:anna] is_a: UBERON:0002050 ! embryonic structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0003068 ! part of axial mesoderm @@ -44215,6 +68661,10 @@ relationship: RO:0002387 UBERON:0003063 ! prechordal plate [Term] id: UBERON:0034903 name: left atrium endocardium +def: "Endocardium that is part of the left atrium." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:7286 +xref: SCTID:190064008 +xref: VHOG:0001226 is_a: UBERON:0002166 ! endocardium of atrium intersection_of: UBERON:0002165 ! endocardium intersection_of: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium @@ -44231,44 +68681,41 @@ relationship: RO:0002572 UBERON:0002530 ! gland [Term] id: UBERON:0034921 name: multi organ part structure +def: "An multicellular anatomical structure that has subparts of multiple organs as a part." [CARO:0020001] +xref: CARO:0020001 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: RO:0002473 UBERON:0000064 ! organ part -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0034922 name: cell cluster +def: "A cluster of cells, largely surrounded by a morphological boundary." [CARO:0020002] +xref: CARO:0020002 +xref: FMA:62807 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: RO:0002219 UBERON:0000015 ! non-material anatomical boundary -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0034923 name: disconnected anatomical group +def: "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other." [CARO:0020000] +xref: CARO:0020000 is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0000086 PATO:0010001 relationship: RO:0002180 UBERON:0000061 {minCardinality="2"} ! has component anatomical structure relationship: RO:0002473 UBERON:0000061 ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0034925 name: anatomical collection +def: "A collection of anatomical structures that are alike in terms of their morphology or developmental origin." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002351 UBERON:0000061 ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0034929 name: external soft tissue zone +def: "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000475 ! part of organism subdivision relationship: BFO:0000051 UBERON:0000014 ! has part zone of skin @@ -44276,9 +68723,20 @@ relationship: BFO:0000051 UBERON:0001015 ! has part musculature relationship: BFO:0000051 UBERON:0001021 ! has part nerve relationship: BFO:0000051 UBERON:0002049 ! has part vasculature +[Term] +id: UBERON:0034932 +name: epithelium of biliary system +def: "The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts." [BTO:0001513, http://orcid.org/0000-0002-6601-2165, MGI:cs] +xref: BTO:0001513 +is_a: UBERON:0000483 ! epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0002294 ! part of biliary system +relationship: BFO:0000050 UBERON:0002294 ! part of biliary system + [Term] id: UBERON:0034933 name: layer of smooth muscle tissue +def: "Any organ component layer that consists of smooth muscle tissue." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0018260 ! layer of muscle tissue intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002473 UBERON:0001135 ! smooth muscle tissue @@ -44287,11 +68745,33 @@ relationship: RO:0002473 UBERON:0001135 ! smooth muscle tissue [Term] id: UBERON:0034944 name: zone of organ +xref: FMA:55268 is_a: UBERON:0000064 ! organ part +[Term] +id: UBERON:0034945 +name: excreted gas +def: "Any gaseous product of an excretory process." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0000174 ! excreta +is_a: UBERON:0034873 ! bodily gas +intersection_of: UBERON:0034873 ! bodily gas +intersection_of: RO:0002353 GO:0007588 ! output of excretion + +[Term] +id: UBERON:0034946 +name: gas excreted from digestive tract +def: "Any excreted gas that is produced by the digestive tract." [http://orcid.org/0000-0002-6601-2165] +comment: In mammals, mostly produced as a byproduct of bacterial fermentation in the gastrointestinal (GI) tract, especially the colon, and excreted through the rectum +xref: FMA:78440 +is_a: UBERON:0034945 ! excreted gas +intersection_of: UBERON:0034945 ! excreted gas +intersection_of: RO:0003001 UBERON:0001555 ! produced by digestive tract +relationship: RO:0003001 UBERON:0001555 ! produced by digestive tract + [Term] id: UBERON:0034947 name: gas in respiratory system +def: "Any portion of gas located in a part of the respiratory system." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0034873 ! bodily gas intersection_of: UBERON:0034873 ! bodily gas intersection_of: RO:0001025 UBERON:0001004 ! respiratory system @@ -44300,6 +68780,8 @@ relationship: RO:0001025 UBERON:0001004 ! respiratory system [Term] id: UBERON:0034969 name: epithelial layer of duct +xref: NCIT:C25787 +xref: UMLS:C1512086 is_a: UBERON:0003914 ! epithelial tube intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000058 ! part of duct @@ -44308,6 +68790,9 @@ relationship: BFO:0000050 UBERON:0000058 ! part of duct [Term] id: UBERON:0034995 name: jaw mesenchyme +def: "Mesenchyme that is part of a developing jaw [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:32907 +xref: EMAPA:35454 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0011595 ! part of jaw region @@ -44316,11 +68801,22 @@ relationship: BFO:0000050 UBERON:0011595 ! part of jaw region [Term] id: UBERON:0035037 name: jaw epithelium +xref: EMAPA:32904 +xref: MA:0003220 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0011595 ! part of jaw region relationship: BFO:0000050 UBERON:0011595 ! part of jaw region +[Term] +id: UBERON:0035039 +name: rectal artery +xref: SCTID:277967008 +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0001052 ! rectum +relationship: RO:0002178 UBERON:0001052 ! rectum + [Term] id: UBERON:0035050 name: excretory duct @@ -44329,6 +68825,7 @@ is_a: UBERON:0000058 ! duct [Term] id: UBERON:0035118 name: material entity in digestive tract +def: "Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included." [https://github.com/EnvironmentOntology/envo/issues/110] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0001025 UBERON:0006909 ! lumen of digestive tract @@ -44337,6 +68834,11 @@ relationship: RO:0001025 UBERON:0006909 ! lumen of digestive tract [Term] id: UBERON:0035159 name: entire surface of organism +def: "Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface." [FMA:61695] +xref: FMA:61695 +xref: NCIT:C29667 +xref: SCTID:261060002 +xref: UMLS:C0489451 is_a: UBERON:0006984 ! anatomical surface intersection_of: UBERON:0006984 ! anatomical surface intersection_of: RO:0002221 UBERON:0000468 ! multicellular organism @@ -44345,6 +68847,10 @@ relationship: RO:0002221 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0035398 name: branch of external carotid artery +xref: FMA:70505 +xref: NCIT:C32552 +xref: SCTID:244216003 +xref: UMLS:C0447038 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002252 UBERON:0001070 ! external carotid artery @@ -44353,6 +68859,11 @@ relationship: RO:0002252 UBERON:0001070 ! external carotid artery [Term] id: UBERON:0035539 name: esophageal artery +def: "Any of several arteries that arise from the aorta and supply blood to the esophagus." [ncithesaurus:Esophageal_Artery] +xref: FMA:4149 +xref: NCIT:C32535 +xref: SCTID:56548006 +xref: UMLS:C0226294 is_a: UBERON:0003834 ! thoracic segment blood vessel is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0001637 ! artery @@ -44360,29 +68871,46 @@ intersection_of: RO:0002178 UBERON:0001043 ! esophagus relationship: RO:0002170 UBERON:0002345 ! descending thoracic aorta relationship: RO:0002178 UBERON:0001043 ! esophagus relationship: RO:0002380 UBERON:0001515 ! thoracic aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035546 name: uveal vein +xref: FMA:51797 +xref: SCTID:149683007 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0001768 ! uvea relationship: RO:0002179 UBERON:0001768 ! uvea +[Term] +id: UBERON:0035548 +name: colic artery +xref: SCTID:77852007 +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0001155 ! colon +relationship: RO:0002178 UBERON:0001155 ! colon + [Term] id: UBERON:0035549 name: vasculature of integument +def: "The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:225275 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: RO:0001025 UBERON:0002199 ! integument relationship: RO:0001025 UBERON:0002199 ! integument relationship: RO:0002216 GO:0001659 ! capable of part of temperature homeostasis -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035550 name: superficial vein +def: "Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers." [ncithesaurus:Superficial_Vein] +xref: FMA:76719 +xref: NCIT:C33666 +xref: SCTID:341382008 +xref: UMLS:C0226513 +xref: Wikipedia:Superficial_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0035549 ! part of vasculature of integument @@ -44391,6 +68919,7 @@ relationship: BFO:0000050 UBERON:0035549 ! part of vasculature of integument [Term] id: UBERON:0035551 name: deep vasculature +def: "The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BSPO:0000107 UBERON:0002199 ! integument @@ -44399,6 +68928,12 @@ relationship: BSPO:0000107 UBERON:0002199 ! integument [Term] id: UBERON:0035552 name: deep vein +def: "A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery." [ncithesaurus:Deep_Vein] +xref: FMA:76718 +xref: NCIT:C32444 +xref: SCTID:341484008 +xref: UMLS:C0226514 +xref: Wikipedia:Deep_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0035551 ! part of deep vasculature @@ -44407,6 +68942,9 @@ relationship: BFO:0000050 UBERON:0035551 ! part of deep vasculature [Term] id: UBERON:0035553 name: left cardiac chamber +def: "Any chamber of the left side of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:7166 +xref: SCTID:362008007 is_a: UBERON:0004151 ! cardiac chamber is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0004151 ! cardiac chamber @@ -44416,6 +68954,9 @@ relationship: BSPO:0000120 UBERON:0000948 ! heart [Term] id: UBERON:0035554 name: right cardiac chamber +def: "Any chamber of the right side of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:7165 +xref: SCTID:362007002 is_a: UBERON:0004151 ! cardiac chamber is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0004151 ! cardiac chamber @@ -44425,12 +68966,20 @@ relationship: BSPO:0000121 UBERON:0000948 ! heart [Term] id: UBERON:0035639 name: ocular adnexa +def: "The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva." [HPO:pr, http://medical-dictionary.thefreedictionary.com/ocular+adnexa, https://github.com/obophenotype/uberon/issues/1132, UBERON:cjm] +xref: FMA:76554 +xref: NCIT:C32574 +xref: SCTID:120612006 +xref: UMLS:C0229243 +xref: Wikipedia:Accessory_visual_structures is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0004088 ! part of orbital region [Term] id: UBERON:0035763 name: cavity of cardiac chamber +xref: EHDAA2:0004181 +xref: FMA:9464 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0004151 ! cardiac chamber @@ -44440,6 +68989,9 @@ relationship: RO:0002572 UBERON:0004151 ! cardiac chamber [Term] id: UBERON:0035767 name: intrapulmonary bronchus +xref: FMA:223208 +xref: NCIT:C12930 +xref: UMLS:C1512970 is_a: UBERON:0002185 ! bronchus intersection_of: UBERON:0002185 ! bronchus intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -44448,14 +69000,28 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: UBERON:0035804 name: future mouth +def: "The primordial mouth region of the developing head." [MP:0003119] +xref: FMA:293105 is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0007026 ! part of presumptive gut relationship: BFO:0000051 UBERON:0000925 ! has part endoderm relationship: BFO:0000051 UBERON:0000930 ! has part stomodeum +[Term] +id: UBERON:0035805 +name: muscle layer of sigmoid colon +def: "A muscle layer that is part of the sigmoid colon." [https://github.com/obophenotype/uberon/issues/1162] +xref: FMA:15028 +is_a: UBERON:0012489 ! muscle layer of colon +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon +relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon + [Term] id: UBERON:0035809 name: serous cavity +xref: FMA:12241 +xref: SCTID:304404008 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0005906 ! serous sac @@ -44464,6 +69030,9 @@ relationship: RO:0002572 UBERON:0005906 ! serous sac [Term] id: UBERON:0035814 name: pericardial fat +def: "The sum of epicardial and paracardial fat deposits." [DOI:10.5935/abc.20130138] +xref: SCTID:42267001 +xref: ZFA:0005765 is_a: UBERON:0035818 ! visceral fat intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002221 UBERON:0000948 ! heart @@ -44472,6 +69041,7 @@ relationship: RO:0002221 UBERON:0000948 ! heart [Term] id: UBERON:0035815 name: paracardial fat +def: "Fat deposits in the mediastinum outside the parietal pericardium ." [DOI:10.5935/abc.20130138] is_a: UBERON:0035814 ! pericardial fat intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002220 UBERON:0002408 ! adjacent to parietal serous pericardium @@ -44481,6 +69051,7 @@ relationship: RO:0002220 UBERON:0002408 ! adjacent to parietal serous pericardiu [Term] id: UBERON:0035818 name: visceral fat +def: "Any fat deposit surrounding a visceral organ." [UBERON:cjm] is_a: UBERON:0001013 ! adipose tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002221 UBERON:0000062 ! organ @@ -44489,6 +69060,9 @@ relationship: RO:0002221 UBERON:0000062 ! organ [Term] id: UBERON:0035819 name: abdominopelvic cavity +def: "The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity." [UBERON:cjm] +xref: FMA:12267 +xref: Wikipedia:Abdominopelvic_cavity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen @@ -44499,6 +69073,9 @@ relationship: RO:0002572 UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0035820 name: peritoneal sac +def: "A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity." [https://github.com/obophenotype/uberon/issues/86] +xref: EMAPA:16137 +xref: FMA:9908 is_a: UBERON:0002075 ! viscus is_a: UBERON:0005906 ! serous sac relationship: BFO:0000051 UBERON:0001179 ! has part peritoneal cavity @@ -44508,6 +69085,8 @@ relationship: RO:0001025 UBERON:0003684 ! abdominal cavity [Term] id: UBERON:0035965 name: wall of blood vessel +xref: BTO:0004378 +xref: FMA:67473 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall @@ -44518,6 +69097,7 @@ relationship: RO:0002473 UBERON:0004797 ! blood vessel layer [Term] id: UBERON:0036072 name: respiratory primordium epithelium +xref: EHDAA2:0004070 is_a: UBERON:0004185 ! endodermal part of digestive tract is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0007499 ! epithelial sac @@ -44531,6 +69111,7 @@ relationship: RO:0002202 UBERON:0007690 ! early pharyngeal endoderm [Term] id: UBERON:0036073 name: respiratory primordium mesenchyme +xref: EHDAA2:0004071 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme @@ -44541,6 +69122,7 @@ relationship: RO:0002202 UBERON:0004873 ! splanchnopleure [Term] id: UBERON:0036146 name: cardiopharyngeal field +def: "An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles." [http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1, https://orcid.org/0000-0003-3308-6245] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -44549,23 +69131,39 @@ is_a: UBERON:0007688 ! anlage [Term] id: UBERON:0036186 name: fibroelastic connective tissue +xref: FMA:83520 is_a: UBERON:0002521 ! elastic tissue is_a: UBERON:0011824 ! fibrous connective tissue intersection_of: UBERON:0011824 ! fibrous connective tissue intersection_of: RO:0002473 GO:0071953 ! elastic fiber +[Term] +id: UBERON:0036214 +name: rectosigmoid junction +def: "An anatomical junction that is between the sigmoid colon and rectum." [https://github.com/obophenotype/uberon/issues/1319, https://www.cdc.gov/cancer/npcr/pdf/abstracting/colon.pdf, NCIT:C54188] +xref: NCIT:C54188 +xref: SCTID:245429006 +is_a: UBERON:8410024 ! intestinal junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0001052 ! rectum +intersection_of: RO:0002176 UBERON:0001159 ! sigmoid colon +relationship: RO:0002176 UBERON:0001052 ! rectum +relationship: RO:0002176 UBERON:0001159 ! sigmoid colon + [Term] id: UBERON:0036215 name: anatomical surface region +def: "Material anatomical entity that forms the outermost boundary of an anatomical structure." [https://github.com/obophenotype/uberon/issues/1324] +xref: AAO:0010270 +xref: ZFA:0005594 is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002007 UBERON:0000061 ! bounding layer of anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0036217 name: coelomic fluid +def: "A bodily fluid that is located in the coelom." [https://github.com/obophenotype/uberon/issues/1326, PMID:10874572] +xref: BTO:0001708 is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid intersection_of: RO:0001025 UBERON:0011997 ! coelom @@ -44574,6 +69172,7 @@ relationship: RO:0001025 UBERON:0011997 ! coelom [Term] id: UBERON:0036225 name: respiratory system gland +def: "Any gland that is part os the respiratory system." [UBERON:cjm] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -44582,19 +69181,17 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0036242 name: post-embryonic notochord +def: "A notochord that has persisted beyond the embryonic stage." [UBERON:cjm] is_a: UBERON:0002328 ! notochord intersection_of: UBERON:0002328 ! notochord intersection_of: BFO:0000050 UBERON:0009953 ! part of post-embryonic organism relationship: BFO:0000050 UBERON:0009953 ! part of post-embryonic organism -property_value: RO:0002175 NCBITaxon:118072 -property_value: RO:0002175 NCBITaxon:7737 -property_value: RO:0002175 NCBITaxon:7746 -property_value: RO:0002175 NCBITaxon:7878 -property_value: RO:0002175 NCBITaxon:8292 [Term] id: UBERON:0036244 name: secretion of serous membrane +def: "A transudate found in the serous sac." [FMA:20932] +xref: FMA:20932 is_a: UBERON:0007779 ! transudate intersection_of: UBERON:0007779 ! transudate intersection_of: filtered_through UBERON:0000042 ! serous membrane @@ -44604,6 +69201,7 @@ relationship: RO:0001025 UBERON:0005906 ! serous sac [Term] id: UBERON:0036253 name: orifice of skull +xref: FMA:53133 is_a: UBERON:0000161 ! orifice intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0003129 ! part of skull @@ -44612,12 +69210,18 @@ relationship: BFO:0000050 UBERON:0003129 ! part of skull [Term] id: UBERON:0036264 name: zygomaticotemporal nerve +def: "The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit." [Wikipedia:Zygomaticotemporal_nerve] +xref: FMA:52972 +xref: SCTID:280243001 +xref: Wikipedia:Zygomaticotemporal_nerve is_a: UBERON:0011779 ! nerve of head region relationship: RO:0002380 UBERON:0000377 ! maxillary nerve [Term] id: UBERON:0036285 name: wall of left ventricle +def: "Wall of ventricle which is continuous with the wall of aorta." [FMA:9556] +xref: FMA:9556 is_a: UBERON:0004784 ! heart ventricle wall intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle @@ -44626,6 +69230,8 @@ relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle [Term] id: UBERON:0036286 name: wall of right ventricle +def: "Wall of ventricle which is continuous with the wall of pulmonary trunk." [FMA:9533] +xref: FMA:9533 is_a: UBERON:0004784 ! heart ventricle wall intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle @@ -44634,6 +69240,7 @@ relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle [Term] id: UBERON:0036288 name: anterior wall of left ventricle +xref: FMA:9560 is_a: UBERON:0036285 ! wall of left ventricle intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BSPO:0000123 UBERON:0002084 ! heart left ventricle @@ -44643,6 +69250,8 @@ relationship: BSPO:0000123 UBERON:0002084 ! heart left ventricle [Term] id: UBERON:0036289 name: anterior wall of right ventricle +def: "Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle." [FMA:9553] +xref: FMA:9553 is_a: UBERON:0036286 ! wall of right ventricle intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BSPO:0000123 UBERON:0002080 ! heart right ventricle @@ -44651,6 +69260,7 @@ relationship: BSPO:0000123 UBERON:0002080 ! heart right ventricle [Term] id: UBERON:0036290 name: myocardium of anterior wall of left ventricle +xref: FMA:87177 is_a: UBERON:0006566 ! left ventricle myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0036288 ! part of anterior wall of left ventricle @@ -44659,6 +69269,7 @@ relationship: BFO:0000050 UBERON:0036288 ! part of anterior wall of left ventric [Term] id: UBERON:0036291 name: myocardium of anterior wall of right ventricle +xref: FMA:260877 is_a: UBERON:0006567 ! right ventricle myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0036289 ! part of anterior wall of right ventricle @@ -44667,11 +69278,24 @@ relationship: BFO:0000050 UBERON:0036289 ! part of anterior wall of right ventri [Term] id: UBERON:0036294 name: mucosa of lip +def: "A mucosa that is part of a lip region [Automatically generated definition]." [OBOL:automatic] +xref: NCIT:C12226 is_a: UBERON:0003729 ! mouth mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001833 ! part of lip relationship: BFO:0000050 UBERON:0001833 ! part of lip +[Term] +id: UBERON:0036301 +name: vasculature of spleen +xref: FMA:225251 +xref: SCTID:297287005 +is_a: UBERON:0002201 ! vasculature of trunk +is_a: UBERON:0006876 ! vasculature of organ +intersection_of: UBERON:0002049 ! vasculature +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + [Term] id: UBERON:0036302 name: vasculature of central nervous system plus retina @@ -44682,14 +69306,26 @@ union_of: UBERON:0036303 ! vasculature of central nervous system [Term] id: UBERON:0036303 name: vasculature of central nervous system +xref: FMA:259905 is_a: UBERON:0036302 ! vasculature of central nervous system plus retina intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system +[Term] +id: UBERON:0036343 +name: wall of gallbladder +xref: FMA:14657 +is_a: UBERON:0003697 ! abdominal wall +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder + [Term] id: UBERON:0036351 name: wall of brachiocephalic artery +xref: FMA:15089 is_a: UBERON:0000415 ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery @@ -44698,14 +69334,27 @@ relationship: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery [Term] id: UBERON:0036352 name: wall of subclavian artery +xref: FMA:15090 is_a: UBERON:0000415 ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001533 ! part of subclavian artery relationship: BFO:0000050 UBERON:0001533 ! part of subclavian artery +[Term] +id: UBERON:0036362 +name: wall of anal canal +xref: FMA:15704 +is_a: UBERON:0001169 ! wall of large intestine +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal + [Term] id: UBERON:0036422 name: wall of pulmonary artery +xref: FMA:18211 is_a: UBERON:0000415 ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery @@ -44714,6 +69363,7 @@ relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery [Term] id: UBERON:0036553 name: wall of synovial tendon sheath +xref: FMA:231590 is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall @@ -44723,15 +69373,28 @@ relationship: BFO:0000050 UBERON:0000304 ! part of tendon sheath [Term] id: UBERON:0036925 name: wall of eyeball +xref: FMA:58098 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye relationship: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye +[Term] +id: UBERON:0037089 +name: wall of orbit +xref: FMA:63144 +is_a: UBERON:0000060 ! anatomical wall +is_a: UBERON:0000075 ! subdivision of skeletal system +is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0001697 ! part of orbit of skull +relationship: BFO:0000050 UBERON:0001697 ! part of orbit of skull + [Term] id: UBERON:0037094 name: wall of common carotid artery +xref: FMA:66284 is_a: UBERON:0000415 ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001530 ! part of common carotid artery plus branches @@ -44740,6 +69403,8 @@ relationship: BFO:0000050 UBERON:0001530 ! part of common carotid artery plus br [Term] id: UBERON:0037144 name: wall of heart +def: "Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees." [FMA:7274] +xref: FMA:7274 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall @@ -44748,9 +69413,43 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002371 UBERON:0002406 ! pericardial sac relationship: RO:0002371 UBERON:0004292 ! cardiac skeleton +[Term] +id: UBERON:0039222 +name: cystic artery +def: "An artery that supplies oxygenated blood to the cystic duct." [http://orcid.org/0000-0002-6601-2165, https://en.wikipedia.org/wiki/Cystic_artery] +xref: FMA:14835 +is_a: UBERON:0001637 ! artery +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0001152 ! cystic duct +relationship: BFO:0000050 UBERON:0015482 ! part of right hepatic artery +relationship: RO:0002178 UBERON:0001152 ! cystic duct + +[Term] +id: UBERON:0039228 +name: sigmoid vein +xref: FMA:15395 +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: RO:0002179 UBERON:0001159 ! sigmoid colon +relationship: RO:0002179 UBERON:0001159 ! sigmoid colon +relationship: RO:0002376 UBERON:0001215 ! inferior mesenteric vein + +[Term] +id: UBERON:0039261 +name: pancreatic artery +xref: FMA:70471 +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0001264 ! pancreas +relationship: RO:0002178 UBERON:0001264 ! pancreas +relationship: RO:0002252 UBERON:0001194 ! splenic artery + [Term] id: UBERON:0039856 name: right ovarian vein +def: "Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament." [FMA:14342] +xref: FMA:14342 is_a: UBERON:0001145 ! ovarian vein intersection_of: UBERON:0001145 ! ovarian vein intersection_of: RO:0002179 UBERON:0002118 ! right ovary @@ -44760,6 +69459,8 @@ relationship: RO:0002376 UBERON:0001072 ! inferior vena cava [Term] id: UBERON:0039857 name: left ovarian vein +def: "Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament." [FMA:14347] +xref: FMA:14347 is_a: UBERON:0001145 ! ovarian vein intersection_of: UBERON:0001145 ! ovarian vein intersection_of: RO:0002179 UBERON:0002119 ! left ovary @@ -44768,22 +69469,47 @@ relationship: RO:0002179 UBERON:0002119 ! left ovary [Term] id: UBERON:1000021 name: skin of face +def: "A zone of skin that is part of the face." [https://github.com/obophenotype/uberon/issues/34, UBERON:EJS] +xref: EMAPA:36657 +xref: FMA:24758 +xref: NCIT:C33561 +xref: SCTID:361703006 is_a: UBERON:0001084 ! skin of head intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001456 ! part of face relationship: BFO:0000050 UBERON:0001456 ! part of face +[Term] +id: UBERON:1000024 +name: parenchyma of spleen +def: "A parenchyma that is part of a spleen." [OBOL:automatic] +xref: FMA:16029 +is_a: UBERON:0000353 ! parenchyma +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + [Term] id: UBERON:1100000 name: digestive tract junction +def: "An anatomical junction between two parts of the digestive tract." [https://orcid.org/0000-0002-7073-9172] is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0004921 ! subdivision of digestive tract relationship: RO:0002176 UBERON:0004921 ! subdivision of digestive tract +[Term] +id: UBERON:2001073 +name: axial vasculature +xref: ZFA:0001073 +is_a: UBERON:0002049 ! vasculature + [Term] id: UBERON:2001457 name: postcranial axial cartilage +def: "Cartilage which is part of the axial skeleton." [ZFIN:curator] +xref: ZFA:0001457 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton @@ -44792,17 +69518,27 @@ relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton [Term] id: UBERON:2005260 name: fenestrated capillary +def: "Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse." [Wikipedia:Capillary#Types, Wikipedia:Fenestra_(histology)] +xref: FMA:63196 +xref: NCIT:C32595 +xref: TAO:0005260 +xref: Wikipedia:Capillary#Types +xref: ZFA:0005260 is_a: UBERON:0001982 ! capillary is_a: UBERON:0004638 ! blood vessel endothelium [Term] id: UBERON:2007013 name: preplacodal ectoderm +def: "Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes." [ZFIN:curator] +xref: ZFA:0007013 is_a: UBERON:0005497 ! non-neural ectoderm [Term] id: UBERON:3000961 name: external integument structure +def: "Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument." [AAO:EJS] +comment: Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305 is_a: UBERON:0003102 ! surface structure intersection_of: UBERON:0003102 ! surface structure intersection_of: BFO:0000050 UBERON:0002199 ! part of integument @@ -44811,6 +69547,7 @@ relationship: BFO:0000050 UBERON:0002199 ! part of integument [Term] id: UBERON:3000972 name: head external integument structure +def: "Dermal, epidermal, glandular and pigment structures of the external head integument." [AAO:EJS] is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:3000961 ! external integument structure intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -44819,14 +69556,25 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:3000977 name: body external integument structure +def: "Dermal, epidermal, glandular and pigment structures of the body integument." [AAO:EJS] is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:3000961 ! external integument structure intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk +[Term] +id: UBERON:3000982 +name: tail external integument structure +def: "Dermal, epidermal, glandular and pigment structures of the tail integument." [AAO:EJS] +is_a: UBERON:3000961 ! external integument structure +intersection_of: UBERON:3000961 ! external integument structure +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:3010200 name: vasculature of respiratory integument +def: "Blood vessels in respiratory skin." [AAO:EJS] is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -44836,6 +69584,7 @@ relationship: BFO:0000050 UBERON:0002199 ! part of integument [Term] id: UBERON:4200230 name: surface of bone +def: "An anatomical surface that is part of a bone." [PHENOSCAPE] is_a: UBERON:0006984 ! anatomical surface intersection_of: UBERON:0006984 ! anatomical surface intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element @@ -44852,6 +69601,7 @@ relationship: BFO:0000050 NCBITaxon:88770 ! part of Panarthropoda [Term] id: UBERON:8000006 name: left side of back +def: "Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane." [https://microbiomedb.org/] is_a: UBERON:0001137 ! dorsum is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001137 ! dorsum @@ -44861,6 +69611,7 @@ relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism [Term] id: UBERON:8000007 name: right side of back +def: "Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane." [https://microbiomedb.org/] is_a: UBERON:0001137 ! dorsum is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001137 ! dorsum @@ -44870,35 +69621,185 @@ relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism [Term] id: UBERON:8000009 name: Purkinje fiber network +def: "A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles." [PMID:26786210] is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system relationship: BFO:0000051 UBERON:0002354 ! has part cardiac Purkinje fiber +[Term] +id: UBERON:8400021 +name: liver serosa +def: "Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact." [https://medical-dictionary.thefreedictionary.com/serosa+of+liver, https://orcid.org/0000-0002-0449-2730] +is_a: UBERON:0000042 ! serous membrane +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + +[Term] +id: UBERON:8400023 +name: liver subserosa +def: "Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson." [FMA:15812, https://medical-dictionary.thefreedictionary.com/subserosa+of+liver, https://orcid.org/0000-0002-0449-2730] +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0012375 ! subserosa +intersection_of: UBERON:0012375 ! subserosa +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + +[Term] +id: UBERON:8410001 +name: small intestine venule +def: "Venule of villus of small intestine." [https://orcid.org/0000-0003-4183-8865] +is_a: UBERON:0001979 ! venule +intersection_of: UBERON:0001979 ! venule +intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus +relationship: BFO:0000050 UBERON:0001213 ! part of intestinal villus + +[Term] +id: UBERON:8410004 +name: small intestine arteriole +def: "Arteriole of villus of small intestine." [http://orcid.org/0000-0003-4183-8865] +is_a: UBERON:0001980 ! arteriole +intersection_of: UBERON:0001980 ! arteriole +intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus +relationship: BFO:0000050 UBERON:0001213 ! part of intestinal villus + +[Term] +id: UBERON:8410008 +name: venule of anorectum +def: "A venule that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: UBERON:0001979 ! venule +intersection_of: UBERON:0001979 ! venule +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: UBERON:8410009 +name: arteriole of anorectum +def: "An arteriole that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: UBERON:0001980 ! arteriole +intersection_of: UBERON:0001980 ! arteriole +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: UBERON:8410015 +name: arteriole of colon +def: "An arteriole located in the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] +is_a: UBERON:0001980 ! arteriole +intersection_of: UBERON:0001980 ! arteriole +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:8410024 +name: intestinal junction +def: "An anatomical junction between two parts of the intestine." [https://orcid.org/0000-0002-7073-9172] +is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +intersection_of: RO:0002176 UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0000160 ! part of intestine + +[Term] +id: UBERON:8410043 +name: bronchus submucosal gland +def: "A submucosal gland located in a bronchus." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] +is_a: UBERON:8410077 ! airway submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus +relationship: BFO:0000050 UBERON:0002185 ! part of bronchus + +[Term] +id: UBERON:8410048 +name: venule of colon +def: "A venule located in the colon." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] +is_a: UBERON:0001979 ! venule +intersection_of: UBERON:0001979 ! venule +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:8410050 +name: anorectum +def: "A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus." [DOI:10.1007/978-3-319-26938-2_8, DOI:10.1148/rg.2015150037, http://orcid.org/0000-0002-6826-8770, http://orcid.org/0000-0003-3440-1876, PMID:29742860] +is_a: UBERON:0004921 ! subdivision of digestive tract +intersection_of: UBERON:0004921 ! subdivision of digestive tract +intersection_of: BFO:0000051 UBERON:0000159 ! has part anal canal +intersection_of: BFO:0000051 UBERON:0001052 ! has part rectum +intersection_of: BFO:0000051 UBERON:0001245 ! has part anus +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000051 UBERON:0000159 ! has part anal canal +relationship: BFO:0000051 UBERON:0001052 ! has part rectum +relationship: BFO:0000051 UBERON:0001245 ! has part anus + +[Term] +id: UBERON:8410056 +name: capillary of anorectum +def: "A capillary that is part of the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: UBERON:0001982 ! capillary +intersection_of: UBERON:0001982 ! capillary +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: UBERON:8410057 +name: capillary of colon +def: "A capillary that is part of the colon." [http://orcid.org/0000-0003-3440-1876] +is_a: UBERON:0001982 ! capillary +intersection_of: UBERON:0001982 ! capillary +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:8410068 +name: capillary of small intestine +def: "A capillary that is part of a small intestine." [http://orcid.org/0000-0003-3440-1876] +is_a: UBERON:0001982 ! capillary +intersection_of: UBERON:0001982 ! capillary +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: UBERON:8410077 +name: airway submucosal gland +def: "A submucosal gland found in a respiratory tract." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] +xref: EFO:0010666 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0011148 ! submucosal gland +is_a: UBERON:0036225 ! respiratory system gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: BFO:0000050 UBERON:0000065 ! part of respiratory tract +relationship: BFO:0000050 UBERON:0000065 ! part of respiratory tract + [Term] id: UBERON:8410081 name: blood microvessel +def: "Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins." [http://orcid.org/0000-0002-7073-9172, Wikipedia:Microcirculation] is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0010523 ! microcirculatory vessel [Term] id: UBERON:8440015 name: noradrenergic cell groups +def: "Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin)." [WikipediaVersioned:Noradrenergic_cell_groups&oldid=965992184] is_a: UBERON:0002616 ! regional part of brain relationship: RO:0002473 CL:0000459 ! noradrenergic cell [Term] id: UBERON:8450002 name: excretory system +def: "An anatomical system that eliminates waste products that arise as a result of metabolic activity." [GO:0007588] is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002215 GO:0046903 ! capable of secretion relationship: RO:0002215 GO:0046903 ! capable of secretion -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:8480001 name: capillary of brain +def: "A capillary that is part of the brain." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0001982 ! capillary is_a: UBERON:0003499 ! brain blood vessel intersection_of: UBERON:0001982 ! capillary @@ -44907,6 +69808,7 @@ intersection_of: BFO:0000050 UBERON:0000955 ! part of brain [Term] id: UBERON:8480002 name: thoracic aorta smooth muscle tissue +def: "A portion of smooth muscle tissue that is part of the thoracic aorta." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0004178 ! aorta smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001515 ! part of thoracic aorta @@ -44915,6 +69817,7 @@ relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta [Term] id: UBERON:8480025 name: skin of clavicle region +def: "A zone of skin that is above the clavicle zone in the pectoral girdle region." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region @@ -44923,6 +69826,7 @@ relationship: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region [Term] id: UBERON:8480029 name: skin of external genitalia +def: "A zone of skin that is part of the external genitalia." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0000014 ! zone of skin is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000014 ! zone of skin @@ -44932,6 +69836,7 @@ relationship: BFO:0000050 UBERON:0004176 ! part of external genitalia [Term] id: UBERON:8480074 name: skin of gonad +def: "A zone of skin part of some gonad." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0000014 ! zone of skin is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000014 ! zone of skin @@ -44941,27 +69846,41 @@ relationship: BFO:0000050 UBERON:0000991 ! part of gonad [Term] id: UBERON:8600004 name: visceral muscle tissue +def: "A muscle tissue that is associated with soft internal organs (viscera)." [BTO:0002780, CLAO:0001295] +comment: It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated. {xref="https://en.wikipedia.org/wiki/Smooth_muscle", xref="FBbt:00005070", comment="PMID:8720463"} is_a: UBERON:0002385 ! muscle tissue relationship: RO:0002473 CL:0008007 ! visceral muscle cell [Term] id: UBERON:8600006 name: visceral striated muscle tissue +def: "A striated muscle tissue that is associated with soft internal organs (viscera)." [https://pressbooks.pub/rbtallitsch/chapter/chapter-6-muscle-tissue/, PMID:8720463] is_a: UBERON:0002036 ! striated muscle tissue is_a: UBERON:8600004 ! visceral muscle tissue +[Term] +id: UBERON:8600012 +name: submucosal gland acinus +def: "A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium." [PMID:17394068, PMID:17707699, PMID:25648514, PMID:30864819] +is_a: UBERON:0014717 ! mucous acinus +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: BFO:0000050 UBERON:0011148 ! part of submucosal gland +relationship: BFO:0000050 UBERON:0011148 ! part of submucosal gland + [Term] id: UBERON:8600017 name: bronchopulmonary segment +def: "A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface." [doi:10.1016/j.mpaic.2008.09.022, FMA:7312, PMID:18271171, PMID:33620799] +comment: A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung. {xref="doi:10.1016/j.mpaic.2008.09.022", xref="PMID:18271171"} is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004119 ! endoderm-derived structure relationship: BFO:0000050 UBERON:0000101 ! part of lobe of lung relationship: RO:0002433 UBERON:0000101 ! lobe of lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:8600024 name: pulmonary venule +def: "A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa." [PMID:22283705, PMID:30247823] is_a: UBERON:0003494 ! respiratory system venule is_a: UBERON:0003512 ! lung blood vessel is_a: UBERON:0005194 ! thoracic vein @@ -44971,28 +69890,103 @@ relationship: BFO:0000050 UBERON:0013127 ! part of pulmonary venous system relationship: RO:0002170 UBERON:0002016 ! pulmonary vein relationship: RO:0002179 UBERON:0016405 ! pulmonary capillary +[Term] +id: http://identifiers.org/ensembl/ENSG00000038945 +name: MSR1 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000050730 +name: TNIP3 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000100292 +name: HMOX1 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000131471 +name: AOC3 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000137804 +name: NUSAP1 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000139329 +name: LUM +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000163735 +name: CXCL5 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000164120 +name: HPGD +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000166803 +name: PCLAF +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000168079 +name: SCARA5 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000170323 +name: FABP4 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000171848 +name: RRM2 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000174807 +name: CD248 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000175063 +name: UBE2C +is_a: SO:0000704 ! gene + [Typedef] id: BFO:0000050 name: part of +xref: BFO:0000050 is_transitive: true inverse_of: BFO:0000051 ! has part [Typedef] id: BFO:0000051 name: has part +xref: BFO:0000051 is_transitive: true [Typedef] id: BFO:0000062 name: preceded by +xref: BFO:0000062 [Typedef] id: BFO:0000063 name: precedes +xref: BFO:0000063 [Typedef] id: BFO:0000066 name: occurs in +xref: BFO:0000066 transitive_over: BFO:0000050 ! part of [Typedef] @@ -45007,36 +70001,44 @@ name: lacks_plasma_membrane_part id: GOREL:0002003 name: results in distribution of name: results_in_distribution_of +xref: GOREL:0002003 [Typedef] id: GOREL:0002004 name: results in fission of name: results_in_fission_of +xref: GOREL:0002004 is_a: RO:0000057 ! has participant [Typedef] id: RO:0000053 name: bearer of +xref: RO:0000053 [Typedef] id: RO:0000056 name: participates in +xref: RO:0000056 [Typedef] id: RO:0000057 name: has participant +xref: RO:0000057 [Typedef] id: RO:0002007 name: bounding layer of +xref: RO:0002007 [Typedef] id: RO:0002087 name: immediately preceded by +xref: RO:0002087 [Typedef] id: RO:0002131 name: overlaps +xref: RO:0002131 [Typedef] id: RO:0002162 @@ -45045,157 +70047,203 @@ holds_over_chain: extends_fibers_into RO:0002162 [Typedef] id: RO:0002180 name: has component +xref: RO:0002180 [Typedef] id: RO:0002211 name: regulates +xref: RO:0002211 is_transitive: true [Typedef] id: RO:0002212 name: negatively regulates +xref: RO:0002212 is_a: RO:0002211 ! regulates [Typedef] id: RO:0002213 name: positively regulates +xref: RO:0002213 holds_over_chain: RO:0002212 RO:0002212 is_a: RO:0002211 ! regulates [Typedef] id: RO:0002215 name: capable of +xref: RO:0002215 [Typedef] id: RO:0002216 name: capable of part of +xref: RO:0002216 [Typedef] id: RO:0002220 name: adjacent to +xref: RO:0002220 [Typedef] id: RO:0002224 name: starts with +xref: RO:0002224 [Typedef] id: RO:0002230 name: ends with +xref: RO:0002230 [Typedef] id: RO:0002231 name: has start location +xref: RO:0002231 [Typedef] id: RO:0002232 name: has end location +xref: RO:0002232 [Typedef] id: RO:0002295 name: results in developmental progression of +xref: RO:0002295 [Typedef] id: RO:0002296 name: results in development of +xref: RO:0002296 [Typedef] id: RO:0002297 name: results in formation of +xref: RO:0002297 [Typedef] id: RO:0002298 name: results in morphogenesis of +xref: RO:0002298 [Typedef] id: RO:0002299 name: results in maturation of +xref: RO:0002299 [Typedef] id: RO:0002315 name: results in acquisition of features of +xref: RO:0002315 + +[Typedef] +id: RO:0002332 +name: regulates levels of +xref: RO:0002332 [Typedef] id: RO:0002338 name: has target start location +xref: RO:0002338 [Typedef] id: RO:0002339 name: has target end location +xref: RO:0002339 [Typedef] id: RO:0002341 name: results in transport along +xref: RO:0002341 [Typedef] id: RO:0002342 name: results in transport across +xref: RO:0002342 [Typedef] id: RO:0002343 name: results in growth of +xref: RO:0002343 [Typedef] id: RO:0002344 name: results in transport to from or in +xref: RO:0002344 [Typedef] id: RO:0002353 name: output of +xref: RO:0002353 [Typedef] id: RO:0002565 name: results in movement of +xref: RO:0002565 [Typedef] id: RO:0002588 name: results in assembly of +xref: RO:0002588 [Typedef] id: RO:0002590 name: results in disassembly of +xref: RO:0002590 [Typedef] id: RO:0002592 name: results in organization of +xref: RO:0002592 is_a: RO:0000057 ! has participant [Typedef] id: RO:0002608 name: process has causal agent +xref: RO:0002608 [Typedef] id: RO:0003000 name: produces +xref: RO:0003000 [Typedef] id: RO:0003001 name: produced by +xref: RO:0003001 [Typedef] id: RO:0004007 name: has primary input or output +xref: RO:0004007 [Typedef] id: RO:0004008 name: has primary output +xref: RO:0004008 [Typedef] id: RO:0004009 name: has primary input +xref: RO:0004009 [Typedef] id: RO:0012003 name: acts on population of +xref: RO:0012003 is_a: RO:0000057 ! has participant [Typedef] id: RO:0012008 name: results in fusion of +xref: RO:0012008 is_a: RO:0002592 ! results in organization of +[Typedef] +id: RO:0015004 +name: has characterizing marker set + [Typedef] id: anteriorly_connected_to name: anteriorly connected to +def: "x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000099 is_a: RO:0002170 is_a: transitively_anteriorly_connected_to ! transitively anteriorly connected to @@ -45219,6 +70267,7 @@ is_transitive: true [Typedef] id: distally_connected_to name: distally connected to +def: "x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000100 is_a: RO:0002170 is_a: transitively_distally_connected_to ! transitively distally connected to @@ -45227,6 +70276,7 @@ inverse_of: proximally_connected_to ! proximally connected to [Typedef] id: extends_fibers_into name: extends_fibers_into +def: "X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y" [https://orcid.org/0000-0002-7073-9172] is_symmetric: true is_a: RO:0002170 @@ -45234,10 +70284,23 @@ is_a: RO:0002170 id: filtered_through name: filtered through def: "Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity." [] +comment: Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed + +[Typedef] +id: indirectly_supplies +name: indirectly_supplies +def: "a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s." [] +is_transitive: true + +[Typedef] +id: layer_part_of +name: layer part of +is_a: BFO:0000050 ! part of [Typedef] id: posteriorly_connected_to name: posteriorly connected to +def: "x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000096 is_a: RO:0002170 @@ -45248,6 +70311,7 @@ name: protects [Typedef] id: proximally_connected_to name: proximally connected to +def: "x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000097 is_a: RO:0002170 is_a: transitively_proximally_connected_to ! transitively proximally connected to @@ -45260,6 +70324,7 @@ def: "c site_of p if c is the bearer of a disposition that is realized by a proc [Typedef] id: subdivision_of name: subdivision of +comment: placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B [Typedef] id: transitively_anteriorly_connected_to diff --git a/clm-full.owl b/clm-full.owl index 6a4ad6f..83d398c 100644 --- a/clm-full.owl +++ b/clm-full.owl @@ -8,13 +8,14 @@ xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" - xmlns:dcterms="http://purl.org/dc/terms/"> + xmlns:dcterms="http://purl.org/dc/terms/" + xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + None Cell Markers Ontology - 2024-07-26 + 2024-07-29 @@ -42,12 +43,6 @@ - - - - - - @@ -102,6 +97,20 @@ + + + + database_cross_reference + + + + + + + + + + + BFO:0000062 preceded by @@ -143,6 +155,7 @@ + BFO:0000063 precedes @@ -155,6 +168,7 @@ + BFO:0000066 occurs in @@ -256,6 +270,24 @@ + + + + + + + + + + + + + + + + + + @@ -275,6 +307,7 @@ + GOREL:0002003 results in distribution of results_in_distribution_of @@ -285,6 +318,7 @@ + GOREL:0002004 results in fission of results_in_fission_of @@ -294,6 +328,7 @@ + RO:0000053 bearer of @@ -302,6 +337,7 @@ + RO:0000056 participates in @@ -310,6 +346,7 @@ + RO:0000057 has participant @@ -348,6 +385,7 @@ + RO:0002007 bounding layer of @@ -362,6 +400,7 @@ + RO:0002087 immediately preceded by @@ -388,6 +427,7 @@ + RO:0002131 overlaps @@ -449,6 +489,7 @@ + RO:0002180 has component @@ -470,6 +511,7 @@ + RO:0002211 regulates @@ -479,6 +521,7 @@ + RO:0002212 negatively regulates @@ -492,6 +535,7 @@ + RO:0002213 positively regulates @@ -500,6 +544,7 @@ + RO:0002215 capable of @@ -508,6 +553,7 @@ + RO:0002216 capable of part of @@ -522,6 +568,7 @@ + RO:0002220 adjacent to @@ -542,11 +589,18 @@ + RO:0002224 starts with + + + + + + @@ -556,6 +610,7 @@ + RO:0002230 ends with @@ -564,6 +619,7 @@ + RO:0002231 has start location @@ -572,6 +628,7 @@ + RO:0002232 has end location @@ -610,6 +667,7 @@ + RO:0002295 results in developmental progression of @@ -618,6 +676,7 @@ + RO:0002296 results in development of @@ -626,6 +685,7 @@ + RO:0002297 results in formation of @@ -634,6 +694,7 @@ + RO:0002298 results in morphogenesis of @@ -642,6 +703,7 @@ + RO:0002299 results in maturation of @@ -650,6 +712,7 @@ + RO:0002315 results in acquisition of features of @@ -661,9 +724,19 @@ + + + + RO:0002332 + regulates levels of + + + + + RO:0002338 has target start location @@ -672,6 +745,7 @@ + RO:0002339 has target end location @@ -680,6 +754,7 @@ + RO:0002341 results in transport along @@ -688,6 +763,7 @@ + RO:0002342 results in transport across @@ -696,6 +772,7 @@ + RO:0002343 results in growth of @@ -704,6 +781,7 @@ + RO:0002344 results in transport to from or in @@ -718,6 +796,7 @@ + RO:0002353 output of @@ -729,6 +808,12 @@ + + + + + + @@ -834,11 +919,18 @@ + RO:0002565 results in movement of + + + + + + @@ -860,6 +952,7 @@ + RO:0002588 results in assembly of @@ -868,6 +961,7 @@ + RO:0002590 results in disassembly of @@ -877,6 +971,7 @@ + RO:0002592 results in organization of @@ -885,6 +980,7 @@ + RO:0002608 process has causal agent @@ -893,6 +989,7 @@ + RO:0003000 produces @@ -901,6 +998,7 @@ + RO:0003001 produced by @@ -909,6 +1007,7 @@ + RO:0004007 has primary input or output @@ -917,6 +1016,7 @@ + RO:0004008 has primary output @@ -925,6 +1025,7 @@ + RO:0004009 has primary input @@ -934,6 +1035,7 @@ + RO:0012003 acts on population of @@ -943,11 +1045,20 @@ + RO:0012008 results in fusion of + + + + has characterizing marker set + + + + @@ -960,14 +1071,27 @@ + + + + + + + x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. anteriorly connected to + + + + x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. + http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -1006,8 +1130,15 @@ + x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y. distally connected to + + + + x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y. + http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -1016,8 +1147,15 @@ + X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y extends_fibers_into + + + + X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y + https://orcid.org/0000-0002-7073-9172 + @@ -1025,18 +1163,45 @@ Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity. + Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed filtered through + + + + + a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s. + indirectly_supplies + + + + + + + + + layer part of + + + + + x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. posteriorly connected to + + + + x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. + http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -1054,8 +1219,15 @@ + x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y. proximally connected to + + + + x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y. + http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -1071,6 +1243,7 @@ + placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B subdivision of @@ -1114,87 +1287,129 @@ - + - + + + MSR1 + - + - + + + TNIP3 + - + - + + + HMOX1 + - + - + + + AOC3 + - + - + + + NUSAP1 + - + - + + + LUM + - + - + + + CXCL5 + - + - + + + HPGD + - + - + + + PCLAF + - + - + + + SCARA5 + - + - + + + FABP4 + - + - + + + RRM2 + - + - + + + CD248 + - + - + + + UBE2C + @@ -1252,18 +1467,36 @@ + + + + + + + + + + + + + + + + + + @@ -1276,12 +1509,24 @@ + + + + + + + + + + + + @@ -1320,18 +1565,36 @@ + + + + + + + + + + + + + + + + + + @@ -1386,18 +1649,36 @@ + + + + + + + + + + + + + + + + + + @@ -1406,6 +1687,36 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1442,6 +1753,12 @@ + + + + + + @@ -1456,9 +1773,7 @@ - - root node - + @@ -1472,11 +1787,40 @@ + + + + + + + A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. + CALOHA:TS-2035 + FMA:68646 + GO:0005623 + KUPO:0000002 + MESH:D002477 + VHOG:0001533 + WBbt:0004017 + XAO:0003012 + A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26. + The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). cell + + + + A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. + CARO:mah + + + + + A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26. + https://doi.org/10.5281/zenodo.11165918 + @@ -1501,8 +1845,15 @@ + Any fibroblast that is derived from the neural crest. neural crest derived fibroblast + + + + Any fibroblast that is derived from the neural crest. + https://orcid.org/0000-0001-5208-3432 + @@ -1523,8 +1874,15 @@ + Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception. neuronal receptor cell + + + + Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception. + FBC:Autogenerated + @@ -1532,8 +1890,15 @@ + A cell found in the embryo before the formation of all the gem layers is complete. early embryonic cell (metazoa) + + + + A cell found in the embryo before the formation of all the gem layers is complete. + GOC:tfm + @@ -1541,8 +1906,16 @@ + Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination. migratory cranial neural crest cell + + + + Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination. + ZFA:0007091 + https://orcid.org/0000-0001-5208-3432 + @@ -1550,8 +1923,16 @@ + Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination. migratory trunk neural crest cell + + + + Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination. + ZFA:0007095 + https://orcid.org/0000-0001-5208-3432 + @@ -1571,8 +1952,15 @@ + A stem cell that is the precursor of gametes. germ line stem cell + + + + A stem cell that is the precursor of gametes. + doi:10.1016/j.stem.2012.05.016 + @@ -1597,8 +1985,20 @@ + Female germ cell is a germ cell that supports female gamete production. + MA:0000388 + VHOG:0001530 + ncithesaurus:Egg female germ cell + + + + Female germ cell is a germ cell that supports female gamete production. + GOC:tfm + PMID:11023867 + PMID:20454446 + @@ -1618,8 +2018,15 @@ + A stem cell that is the precursor of female gametes. female germ line stem cell + + + + A stem cell that is the precursor of female gametes. + doi:10.1016/j.stem.2012.05.016 + @@ -1641,8 +2048,21 @@ + A female germ cell that has entered meiosis. + BTO:0000964 + CALOHA:TS-0711 + FMA:18644 + MESH:D009865 + WBbt:0006797 oocyte + + + + A female germ cell that has entered meiosis. + GOC:tfm + ISBN:0721662544 + @@ -1674,8 +2094,17 @@ + An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes. + FMA:83673 oogonial cell + + + + An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes. + GOC:tfm + ISBN:0721662544 + @@ -1696,8 +2125,21 @@ + A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization. + BTO:0000369 + BTO:0003801 + CALOHA:TS-2191 + FMA:67343 + MESH:D010063 egg cell + + + + A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization. + GOC:tfm + ISBN:0721662544 + @@ -1722,8 +2164,15 @@ + A smooth muscle cell derived from the neural crest. smooth muscle cell neural crest derived + + + + A smooth muscle cell derived from the neural crest. + https://orcid.org/0000-0001-5208-3432 + @@ -1755,8 +2204,15 @@ + Any neuron that develops from some migratory neural crest cell. neural crest derived neuron + + + + Any neuron that develops from some migratory neural crest cell. + FBC:Autogenerated + @@ -1771,8 +2227,18 @@ + A cell that will develop into a neuron often after a migration phase. + BTO:0000930 + FMA:70563 neuroblast (sensu Vertebrata) + + + + A cell that will develop into a neuron often after a migration phase. + GOC:NV + http://en.wikipedia.org/wiki/Neuroblast + @@ -1803,9 +2269,19 @@ - + A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + CALOHA:TS-2086 + FMA:63368 + This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. stem cell + + + + A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + GOC:tfm + MESH:D013234 + @@ -1834,8 +2310,16 @@ + A stem cell that self-renews as well as give rise to a single mature cell type. + FMA:70569 single fate stem cell + + + + A stem cell that self-renews as well as give rise to a single mature cell type. + GOC:tfm + @@ -1992,9 +2476,25 @@ - + A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. + BTO:0000725 + CALOHA:TS-0448 + FMA:86475 + MESH:D006412 + VHOG:0001485 + Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. hematopoietic stem cell + + + + A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. + GOC:add + GOC:dsd + GOC:tfm + PMID:19022770 + http://en.wikipedia.org/wiki/Hematopoietic_stem_cell + @@ -2009,8 +2509,17 @@ + A progenitor cell committed to the erythroid lineage. + BTO:0004911 erythroid progenitor cell + + + + A progenitor cell committed to the erythroid lineage. + GOC:add + ISBN:0721601464 + @@ -2024,8 +2533,17 @@ + A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. + Originally this term had some plant germ line cell children. germ line cell + + + + A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. + GOC:tfm + ISBN:0721662544 + @@ -2091,8 +2609,21 @@ + A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus. + CALOHA:TS-1195 + FMA:83553 + Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. monoblast + + + + A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus. + GOC:add + PMID:1104740 + http://en.wikipedia.org/wiki/Monoblast + http://www.copewithcytokines.de + @@ -2121,8 +2652,16 @@ + A stem cell that can give rise to multiple lineages of cells. + FMA:84789 multi fate stem cell + + + + A stem cell that can give rise to multiple lineages of cells. + GOC:add + @@ -2133,9 +2672,19 @@ - + A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. + BTO:0004730 + This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). common myeloid progenitor + + + + A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. + GOC:add + ISBN:0878932437 + MESH:D023461 + @@ -2174,9 +2723,21 @@ - + A progenitor cell committed to the megakaryocyte and erythroid lineages. + MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. megakaryocyte-erythroid progenitor cell + + + + A progenitor cell committed to the megakaryocyte and erythroid lineages. + GOC:add + GOC:dsd + GOC:tfm + MESH:D055015 + PMID:16647566 + http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell + @@ -2202,9 +2763,20 @@ - + A oligopotent progenitor cell committed to the lymphoid lineage. + CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. common lymphoid progenitor + + + + A oligopotent progenitor cell committed to the lymphoid lineage. + GOC:add + GOC:dsd + GOC:tfm + PMID:10407577 + PMID:16551251 + @@ -2212,8 +2784,18 @@ + A stem cell from which all cells of the body can form. + FMA:84790 + MESH:D039901 totipotent stem cell + + + + A stem cell from which all cells of the body can form. + GOC:add + GOC:tfm + @@ -2221,8 +2803,18 @@ + A precursor cell with a limited number of potential fates. + BTO:0000125 + FMA:84782 + define using PATO mulit-potent or oligopotent? non-terminally differentiated cell + + + + A precursor cell with a limited number of potential fates. + SANBI:mhl + @@ -2230,8 +2822,21 @@ + A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. + BTO:0000222 + CALOHA:TS-0650 + FMA:70335 + VHOG:0001529 myoblast + + + + A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. + GOC:tfm + MESH:D032446 + PMID:21849021 + @@ -2246,9 +2851,23 @@ - + A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. + BTO:0000452 + CALOHA:TS-0362 + FMA:63877 + NCIT:C12482 + VHOG:0001482 + These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. fibroblast + + + + A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. + ISBN:0517223651 + MESH:D005347 + http://en.wikipedia.org/wiki/Fibroblast + @@ -2270,8 +2889,19 @@ + Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell. + BTO:0003607 + FMA:66783 chondroblast + + + + Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell. + GOC:tfm + GO_REF:0000034 + ISBN:0618947256 + @@ -2296,8 +2926,17 @@ + A cell that has a filiform extrusion of the cell surface. + VHOG:0001532 + XAO:0000031 ciliated cell + + + + A cell that has a filiform extrusion of the cell surface. + GOC:tfm + @@ -2312,9 +2951,22 @@ - + A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. + BTO:0000414 + CALOHA:TS-2026 + CARO:0000077 + FMA:66768 + WBbt:0003672 epithelial cell + + + + A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. + FB:ma + GOC:tfm + MESH:D004847 + @@ -2334,8 +2986,16 @@ + An epithelial cell that has a cilia. + FMA:70605 ciliated epithelial cell + + + + An epithelial cell that has a cilia. + GOC:tfm + @@ -2360,8 +3020,15 @@ + An epithelial cell that is part of a duct. duct epithelial cell + + + + An epithelial cell that is part of a duct. + https://orcid.org/0000-0001-5208-3432 + @@ -2401,9 +3068,15 @@ - + An endothelial cell that lines the vasculature. blood vessel endothelial cell + + + + An endothelial cell that lines the vasculature. + GOC:tfm + @@ -2411,9 +3084,16 @@ - + A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. columnar/cuboidal epithelial cell + + + + A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. + GO:0002065 + https://orcid.org/0000-0001-5208-3432 + @@ -2421,6 +3101,7 @@ + CALOHA:TS-1249 squamous epithelial cell @@ -2432,9 +3113,17 @@ - + A flattened epithelial cell of mesenchymal origin that lines the serous cavity. + FMA:66773 mesothelial cell + + + + A flattened epithelial cell of mesenchymal origin that lines the serous cavity. + GOC:tfm + ISBN:0721662544 + @@ -2459,8 +3148,15 @@ + A cell which moves among different tissues of the body, via blood, lymph, or other medium. circulating cell + + + + A cell which moves among different tissues of the body, via blood, lymph, or other medium. + GOC:add + @@ -2485,8 +3181,18 @@ + A cell found predominately in the blood. + FMA:62844 + MESH:D001773 blood cell + + + + A cell found predominately in the blood. + GOC:add + GOC:tfm + @@ -2511,8 +3217,50 @@ + An epithelial cell of the lung. + BTO:0004299 epithelial cell of lung + + + + An epithelial cell of the lung. + https://orcid.org/0000-0001-5208-3432 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the pancreas. + BTO:0000028 + epithelial cell of pancreas + + + + + An epithelial cell of the pancreas. + GOC:tfm + @@ -2543,9 +3291,22 @@ - + A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. + BTO:0000782 + CALOHA:TS-1001 + FMA:62870 + MESH:D013601 + VHOG:0001479 T cell + + + + A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. + GOC:add + GOC:tfm + ISBN:0781735149 + @@ -2652,8 +3413,26 @@ + A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. + BTO:0000968 + CALOHA:TS-0721 + FMA:66781 + MESH:D010010 + Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. osteoclast + + + + A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. + GOC:add + GOC:tfm + GO_REF:0000031 + ISBN:0781735149 + PMID:10428500 + PMID:15055519 + PMID:17380158 + @@ -2753,9 +3532,22 @@ - + A leukocyte with abundant granules in the cytoplasm. + BTO:0000539 + BTO:0001026 + CALOHA:TS-0422 + FMA:62854 granulocyte + + + + A leukocyte with abundant granules in the cytoplasm. + GOC:amm + GOC:tfm + MESH:D006098 + http://en.wikipedia.org/wiki/Granulocyte + @@ -2791,8 +3583,19 @@ + A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells. + BTO:0004301 + The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). sensory epithelial cell + + + + A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells. + GOC:tfm + ISBN:0517223651 + ISBN:0721662544 + @@ -2800,9 +3603,19 @@ - + Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. + BTO:0003811 + FMA:67313 + WBbt:0005113 interneuron + + + + Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. + GOC:tfm + MESH:D007395 + @@ -2810,9 +3623,19 @@ - + An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. + BTO:0000312 + FMA:83617 + WBbt:0005409 motor neuron + + + + An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. + MESH:D009046 + PMID:16875686 + @@ -2837,9 +3660,19 @@ - + Any neuron having a sensory function; an afferent neuron conveying sensory impulses. + BTO:0001037 + FMA:84649 + MESH:D011984 + WBbt:0005759 sensory neuron + + + + Any neuron having a sensory function; an afferent neuron conveying sensory impulses. + ISBN:0721662544 + @@ -2864,8 +3697,16 @@ + A neuron whose cell body is within an autonomic ganglion. + FMA:80121 autonomic neuron + + + + A neuron whose cell body is within an autonomic ganglion. + GOC:tfm + @@ -2885,9 +3726,18 @@ - + A vertebrate phagocyte with a single nucleus. + BTO:0001433 mononuclear phagocyte + + + + A vertebrate phagocyte with a single nucleus. + GOC:add + GOC:tfm + ISBN:0781735149 + @@ -2902,9 +3752,23 @@ - + An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm. + BTO:0001176 + CALOHA:TS-0278 + FMA:66772 + From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. endothelial cell + + + + An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm. + GOC:tfm + MESH:D042783 + PMID:21275341 + http://en.wikipedia.org/wiki/Endothelial_cell + https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855 + @@ -2934,9 +3798,19 @@ - + A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. + BTO:0002606 + CALOHA:TS-0415 + FMA:54536 + Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 glial cell + + + + A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. + MESH:D009457 + @@ -2944,8 +3818,16 @@ + Ectoderm destined to be nervous tissue. neurectodermal cell + + + + Ectoderm destined to be nervous tissue. + GOC:tfm + ISBN:068340007X + @@ -2954,8 +3836,27 @@ + A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. + BTO:0002625 + BTO:0003298 + FMA:70546 + Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. mesenchymal stem cell + + + + A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. + FB:ma + GOC:dsd + PMCID:PMC2613570 + PMID:10102814 + PMID:16923606 + PMID:17986482 + PMID:19960544 + http://en.wikipedia.org/wiki/Mesenchymal_stem_cell + http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells + @@ -2971,9 +3872,18 @@ - + A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides. + BTO:0000443 + CALOHA:TS-0012 + FMA:63880 adipocyte + + + + A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides. + MESH:D017667 + @@ -2994,8 +3904,19 @@ + Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell. + BTO:0000249 + CALOHA:TS-0138 + FMA:66782 chondrocyte + + + + Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell. + GO_REF:0000034 + MESH:D019902 + @@ -3020,8 +3941,17 @@ + A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. + Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. professional antigen presenting cell + + + + A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. + GOC:add + ISBN:0781735149 + @@ -3029,8 +3959,16 @@ + A pigment cell is a cell that contains pigment granules. + VHOG:0001678 pigment cell + + + + A pigment cell is a cell that contains pigment granules. + GOC:tfm + @@ -3054,8 +3992,17 @@ + A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. + CALOHA:TS-2085 + FMA:86494 glandular epithelial cell + + + + A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. + GOC:tfm + @@ -3080,8 +4027,18 @@ + A cell that specializes in controlled release of one or more substances. + BTO:0003659 + FMA:86916 secretory cell + + + + A cell that specializes in controlled release of one or more substances. + GOC:tfm + ISBN:0721662544 + @@ -3106,8 +4063,16 @@ + A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct. + FMA:16014 exocrine cell + + + + A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct. + ISBN:0198547684 + @@ -3116,8 +4081,15 @@ + A cell that secretes glycosaminoglycans. glycosaminoglycan secreting cell + + + + A cell that secretes glycosaminoglycans. + GOC:tfm + @@ -3142,8 +4114,15 @@ + Any secretory cell that is capable of some protein secretion. protein secreting cell + + + + Any secretory cell that is capable of some protein secretion. + FBC:Autogenerated + @@ -3168,8 +4147,16 @@ + A cell that specializes in secretion of surfactant in the alveoli of the lung. surfactant secreting cell + + + + A cell that specializes in secretion of surfactant in the alveoli of the lung. + GOC:tfm + ISBN:0721662544 + @@ -3185,9 +4172,22 @@ - + A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium. + BTO:0004811 + FMA:14119 club cell + + + + A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium. + DOI:10.1183/09031936.00146609 + DOI:10.1378/chest.12-2762 + GOC:tfm + PMID:28128362 + PMID:29874100 + PMID:7905712 + @@ -3247,9 +4247,16 @@ - + A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. + FMA:83809 endocrine cell + + + + A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. + MESH:D055098 + @@ -3258,8 +4265,19 @@ + An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. + BTO:0003865 + FMA:62930 + MESH:D019858 enteroendocrine cell + + + + An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. + GOC:tfm + SANBI:mhl + @@ -3280,9 +4298,29 @@ - + A neuron that is capable of some hormone secretion in response to neuronal signals. + BTO:0002691 + FMA:83810 + The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. + +The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. neuroendocrine cell + + + + A neuron that is capable of some hormone secretion in response to neuronal signals. + MESH:D055099 + + + + + The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. + +The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. + PMID:5342440 + https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073 + @@ -3307,8 +4345,102 @@ + Any secretory cell that is capable of some peptide hormone secretion. peptide hormone secreting cell + + + + Any secretory cell that is capable of some peptide hormone secretion. + FBC:Autogenerated + + + + + + + + + + + + + + + + + + + + + + + + + + + Any secretory cell that is capable of some insulin secretion. + BTO:0000783 + insulin secreting cell + + + + + Any secretory cell that is capable of some insulin secretion. + FBC:Autogenerated + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A cell that secretes insulin and is located towards the center of the islets of Langerhans. + BTO:0000783 + EV:0200009 + FMA:70586 + MA:0002419 + ncithesaurus:Beta_Cell + Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. + type B pancreatic cell + + + + + A cell that secretes insulin and is located towards the center of the islets of Langerhans. + GOC:tfm + ISBN:0517223651 + http://en.wikipedia.org/wiki/Pancreatic_b_cell + @@ -3333,8 +4465,60 @@ + A cell that secretes glucagon. + FMA:84045 glucagon secreting cell + + + + A cell that secretes glucagon. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon. + BTO:0000990 + FMA:70585 + MESH:D050416 + pancreatic A cell + + + + + A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon. + GOC:tfm + ISBN:0721662544 + @@ -3359,8 +4543,58 @@ + Any secretory cell that is capable of some somatostatin secretion. somatostatin secreting cell + + + + Any secretory cell that is capable of some somatostatin secretion. + FBC:Autogenerated + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin. + BTO:0000803 + FMA:70587 + pancreatic D cell + + + + + A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin. + FMA:0517223651 + GOC:tfm + @@ -3385,8 +4619,65 @@ + Any secretory cell that is capable of some steroid hormone secretion. steroid hormone secreting cell + + + + Any secretory cell that is capable of some steroid hormone secretion. + FBC:Autogenerated + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. + BTO:0000575 + CALOHA:TS-0454 + FMA:14515 + Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. + hepatocyte + + + + + The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. + GOC:tfm + ISBN:0412046911 + MESH:D022781 + PMID:19717280 + http://en.wikipedia.org/wiki/Hepatocyte + @@ -3394,8 +4685,15 @@ + A cell whose primary function is to shorten. contractile cell + + + + A cell whose primary function is to shorten. + FB:ma + @@ -3411,8 +4709,20 @@ + A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. + BTO:0000888 + BTO:0000902 + CALOHA:TS-2032 + FMA:67328 + WBbt:0003675 muscle cell + + + + A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. + MESH:D032342 + @@ -3437,9 +4747,18 @@ - + A somatic cell located in skeletal muscle. + BTO:0004392 + CALOHA:TS-2158 + FMA:9727 cell of skeletal muscle + + + + A somatic cell located in skeletal muscle. + GOC:tfm + @@ -3454,9 +4773,20 @@ - + A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast). + BTO:0004576 + CALOHA:TS-2159 + FMA:14072 smooth muscle cell + + + + A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast). + MESH:D032389 + PMID:9315361 + http://en.wikipedia.org/wiki/Smooth_muscle_cell + @@ -3492,6 +4822,7 @@ A cell that is capable of detection of a stimulus involved in sensory perception. + MESH:D011984 sensory receptor cell @@ -3518,8 +4849,15 @@ + A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. chemoreceptor cell + + + + A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. + MESH:D002628 + @@ -3544,8 +4882,18 @@ + A cell specialized to detect and transduce light. + BTO:0001060 + CALOHA:TS-0868 + FMA:86740 photoreceptor cell + + + + A cell specialized to detect and transduce light. + MESH:D010786 + @@ -3553,8 +4901,15 @@ + A cell whose function is determined by the generation or the reception of an electric signal. electrically active cell + + + + A cell whose function is determined by the generation or the reception of an electric signal. + FB:ma + @@ -3562,8 +4917,15 @@ + A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism. lining cell + + + + A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism. + JB:jb + @@ -3579,6 +4941,7 @@ A cell located in the synovial joint. + CALOHA:TS-0995 synovial cell @@ -3588,8 +4951,15 @@ + A cell whose primary function is to prevent the transport of stuff across compartments. barrier cell + + + + A cell whose primary function is to prevent the transport of stuff across compartments. + JB:jb + @@ -3614,8 +4984,15 @@ + A cell that moves by its own activities. motile cell + + + + A cell that moves by its own activities. + FB:ma + @@ -3629,8 +5006,16 @@ + A cell of the outer of the three germ layers of the embryo. + FMA:72549 ectodermal cell + + + + A cell of the outer of the three germ layers of the embryo. + MESH:D004475 + @@ -3644,8 +5029,16 @@ + A cell of the middle germ layer of the embryo. + FMA:72554 mesodermal cell + + + + A cell of the middle germ layer of the embryo. + MESH:D008648 + @@ -3659,8 +5052,16 @@ + A cell of the inner of the three germ layers of the embryo. + FMA:72555 endodermal cell + + + + A cell of the inner of the three germ layers of the embryo. + MESH:D004707 + @@ -3685,8 +5086,16 @@ + A cell with a single nucleus. single nucleate cell + + + + A cell with a single nucleus. + FB:ma + GOC:tfm + @@ -3711,8 +5120,17 @@ + A cell with more than one nucleus. + AEO:0000203 + WBbt:0008074 multinucleate cell + + + + A cell with more than one nucleus. + FB:ma + @@ -3773,9 +5191,19 @@ - + A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. + BTO:0000424 + CALOHA:TS-0290 + FMA:81100 erythrocyte + + + + A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. + GOC:tfm + MESH:D004912 + @@ -3802,8 +5230,19 @@ + Any cell capable of ingesting particulate matter via phagocytosis. + BTO:0001044 + FMA:83806 + MESH:D010586 phagocyte + + + + Any cell capable of ingesting particulate matter via phagocytosis. + GOC:add + ISBN:0721601464 + @@ -3844,9 +5283,25 @@ - + A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. + BTO:0000801 + CALOHA:TS-0587 + FMA:63261 + FMA:83585 + MESH:D008264 + Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. macrophage + + + + A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. + GOC:add + GOC:tfm + GO_REF:0000031 + PMID:16213494 + PMID:1919437 + @@ -3871,8 +5326,16 @@ + Any cell that only exists in Eukaryota. + MESH:D005057 eukaryotic cell + + + + Any cell that only exists in Eukaryota. + FBC:Autogenerated + @@ -3897,8 +5360,15 @@ + Any cell that only exists in Eumycetozoa. Eumycetozoan cell + + + + Any cell that only exists in Eumycetozoa. + FBC:Autogenerated + @@ -3923,9 +5393,15 @@ - + Any photoreceptor cell that is part of some eye. eye photoreceptor cell + + + + Any photoreceptor cell that is part of some eye. + FBC:Autogenerated + @@ -3933,8 +5409,15 @@ + A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. structural cell + + + + A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. + TAIR:sr + @@ -3964,8 +5447,18 @@ + A mature sexual reproductive cell having a single set of unpaired chromosomes. + CALOHA:TS-0395 + FMA:18649 gamete + + + + A mature sexual reproductive cell having a single set of unpaired chromosomes. + GOC:tfm + ISBN:0721662544 + @@ -4005,8 +5498,17 @@ + An epithelial cell found in the trachea. + FMA:74793 + This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' tracheal epithelial cell + + + + An epithelial cell found in the trachea. + GOC:tfm + @@ -4014,8 +5516,53 @@ + Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid. + BTO:0003687 + FMA:62511 serous secreting cell + + + + Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid. + GOC:tfm + ISBN:0517223651 + ISBN:0721662544 + + + + + + + + + + + + + + + + + + + + + + + + + + Any secretory cell that is capable of some mucus secretion. + BTO:0003689 + mucus secreting cell + + + + + Any secretory cell that is capable of some mucus secretion. + FBC:Autogenerated + @@ -4030,8 +5577,20 @@ + An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates. + BTO:0000395 + CALOHA:TS-2168 + FMA:62499 pulmonary alveolar epithelial cell + + + + An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates. + GOC:tfm + PMID:20054144 + PMID:29463737 + @@ -4039,8 +5598,15 @@ + A cell that is specialised to accumulate a particular substance(s). stuff accumulating cell + + + + A cell that is specialised to accumulate a particular substance(s). + FB:ma + @@ -4074,8 +5640,15 @@ + Any cell that is capable of some oxygen transport. oxygen accumulating cell + + + + Any cell that is capable of some oxygen transport. + FBC:Autogenerated + @@ -4091,8 +5664,16 @@ + A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. + FMA:86667 migratory neural crest cell + + + + A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. + doi:10.1016/j.stem.2015.02.017 + @@ -4100,8 +5681,16 @@ + A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors. mesenchyme condensation cell + + + + A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors. + GOC:tfm + PMID:5025404 + @@ -4133,8 +5722,15 @@ + A cell of the sclera of the eye. scleral cell + + + + A cell of the sclera of the eye. + GOC:add + @@ -4166,8 +5762,15 @@ + A structural cell that is part of optic choroid. choroidal cell of the eye + + + + A structural cell that is part of optic choroid. + GOC:add + @@ -4192,8 +5795,15 @@ + Any cell that is part of some extraembryonic structure. extraembryonic cell + + + + Any cell that is part of some extraembryonic structure. + FBC:Autogenerated + @@ -4207,8 +5817,17 @@ + A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. + FMA:83028 trophoblast cell + + + + A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. + GOC:tfm + MESH:D014327 + @@ -4216,8 +5835,16 @@ + A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation. epiblast cell + + + + A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation. + GOC:tfm + ISBN:0618947256 + @@ -4225,8 +5852,17 @@ + An undifferentiated cell produced by early cleavages of the fertilized egg (zygote). + BTO:0001473 + FMA:72551 blastoderm cell + + + + An undifferentiated cell produced by early cleavages of the fertilized egg (zygote). + MESH:D001756 + @@ -4246,8 +5882,50 @@ + A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell. + FMA:86767 + Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. multi-potent skeletal muscle stem cell + + + + A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell. + PMID:18282570 + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. + sphincter associated smooth muscle cell + + + + + A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. + GOC:cjm + @@ -4273,9 +5951,16 @@ - + A smooth muscle cell associated with the vasculature. vascular associated smooth muscle cell + + + + A smooth muscle cell associated with the vasculature. + GOC:dsd + GOC:tfm + @@ -4300,8 +5985,20 @@ + An epithelial cell of the integument (the outer layer of an organism). + BTO:0001470 + CALOHA:TS-0283 + FMA:62411 + MESH:D000078404 epidermal cell + + + + An epithelial cell of the integument (the outer layer of an organism). + Flybase:dsj + MA:ma + @@ -4328,8 +6025,18 @@ + Diploid cell produced by the fusion of sperm cell nucleus and egg cell. + BTO:0000854 + EHDAA2:0004546 + FMA:72395 animal zygote + + + + Diploid cell produced by the fusion of sperm cell nucleus and egg cell. + ISBN:0471245208 + @@ -4346,8 +6053,15 @@ + A cell whose function is determined by its response to an electric signal. electrically responsive cell + + + + A cell whose function is determined by its response to an electric signal. + FB:ma + @@ -4372,8 +6086,15 @@ + Any interneuron that has its soma located in some ganglion. ganglion interneuron + + + + Any interneuron that has its soma located in some ganglion. + FBC:Autogenerated + @@ -4393,9 +6114,16 @@ - + An interneuron that has its cell body in a central nervous system. + Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system. CNS interneuron + + + + An interneuron that has its cell body in a central nervous system. + doi:10.1016/B978-0-12-817424-1.00001-X + @@ -4403,8 +6131,50 @@ + A cell that initiates an electrical signal and passes that signal to another cell. electrically signaling cell + + + + A cell that initiates an electrical signal and passes that signal to another cell. + FB:ma + + + + + + + + + + + + + + + + + + + + + + + + + + A cell that contains more than two haploid sets of chromosomes. + polyploid cell + + + + + A cell that contains more than two haploid sets of chromosomes. + FB:ma + PMID:32646579 + https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy + @@ -4429,8 +6199,25 @@ + A cell whose nucleus contains a single haploid genome. haploid cell + + + + A cell whose nucleus contains a single haploid genome. + FB:ma + GOC:tfm + + + + + + + + + endopolyploid cell + @@ -4548,9 +6335,20 @@ - + A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative). + BTO:0002042 + CALOHA:TS-0194 + FMA:83036 + MESH:D003713 dendritic cell + + + + A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative). + GOC:add + ISBN:0781735149 + @@ -4584,8 +6382,16 @@ + A cell type that secretes 5-Hydroxytryptamine (serotonin). serotonin secreting cell + + + + A cell type that secretes 5-Hydroxytryptamine (serotonin). + GOC:tfm + PMID:19630576 + @@ -4610,8 +6416,16 @@ + A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. noradrenergic cell + + + + A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. + GOC:tfm + ISBN:068340007X + @@ -4619,8 +6433,15 @@ + A cell whose primary function is to protect the organism. defensive cell + + + + A cell whose primary function is to protect the organism. + JB:jb + @@ -4645,8 +6466,15 @@ + A photoreceptor cell that detects visible light. visible light photoreceptor cell + + + + A photoreceptor cell that detects visible light. + GOC:tfm + @@ -4661,9 +6489,113 @@ - + A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. + BTO:0002064 + FMA:83624 stromal cell + + + + A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. + GOC:tfm + MESH:D017154 + + + + + + + + + + A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. + FMA:62935 + type D enteroendocrine cell + + + + + A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. + MESH:D019864 + + + + + + + + + An endorphine cell that secretes enkephalin. + enkephalin secreting cell + + + + + An endorphine cell that secretes enkephalin. + GO:tfm + + + + + + + + + A peptide hormone secreting cell that secretes endorphin. + endorphin secreting cell + + + + + A peptide hormone secreting cell that secretes endorphin. + GO:tfm + + + + + + + + + + + + + + + + + + An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli. + BTO:0004108 + FMA:67609 + type G enteroendocrine cell + + + + + An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli. + GOC:tfm + ISBN:0517223651 + MESH:D019863 + + + + + + + + + A peptide hormone secreting cell that secretes gastrin. + gastrin secreting cell + + + + + A peptide hormone secreting cell that secretes gastrin. + GO:tfm + @@ -4693,8 +6625,17 @@ + A precursor cell destined to differentiate into cardiac muscle cell. + FMA:84797 cardiac muscle myoblast + + + + A precursor cell destined to differentiate into cardiac muscle cell. + GOC:tfm + MESH:D032386 + @@ -4719,8 +6660,17 @@ + A precursor cell destined to differentiate into smooth muscle myocytes. + FMA:84798 smooth muscle myoblast + + + + A precursor cell destined to differentiate into smooth muscle myocytes. + GOC:tfm + MESH:D032390 + @@ -4752,8 +6702,16 @@ + A myoblast that differentiates into skeletal muscle fibers. + FMA:84799 skeletal muscle myoblast + + + + A myoblast that differentiates into skeletal muscle fibers. + SANBI:mhl + @@ -4768,8 +6726,15 @@ + A phagocyte in vertebrates that is able to phagocytosis. phagocyte (sensu Vertebrata) + + + + A phagocyte in vertebrates that is able to phagocytosis. + GOC:tfm + @@ -4794,8 +6759,15 @@ + Any cell that only exists in Fungi. fungal cell + + + + Any cell that only exists in Fungi. + FBC:Autogenerated + @@ -4821,9 +6793,17 @@ - + A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy. + FMA:83043 syncytiotrophoblast cell + + + + A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy. + GOC:tfm + ISBN:0323052908 + @@ -4831,9 +6811,17 @@ - + A neuron which conveys sensory information centrally from the periphery. + FMA:87653 afferent neuron + + + + A neuron which conveys sensory information centrally from the periphery. + GOC:tfm + MESH:D009475 + @@ -4841,8 +6829,15 @@ + A neuron which sends impulses peripherally to activate muscles or secretory cells. efferent neuron + + + + A neuron which sends impulses peripherally to activate muscles or secretory cells. + MESH:D009476 + @@ -4858,9 +6853,22 @@ - + The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. + BTO:0000938 + CALOHA:TS-0683 + FMA:54527 + VHOG:0001483 + WBbt:0003679 + These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. neuron + + + + The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. + MESH:D009474 + http://en.wikipedia.org/wiki/Neuron + @@ -4916,9 +6924,23 @@ - + A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + BTO:0000775 + CALOHA:TS-0583 + FMA:62863 + MESH:D008214 + VHOG:0001535 + Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) lymphocyte + + + + A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + GOC:add + ISBN:0683073696 + ISBN:0781735149 + @@ -5094,8 +7116,17 @@ + An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. + FMA:83518 proerythroblast + + + + An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. + ISBN:0721601464 + PMID:1638021 + @@ -5140,8 +7171,17 @@ + A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers. + FMA:83505 basophilic erythroblast + + + + A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers. + GOC:tfm + ISBN:0721601464 + @@ -5192,8 +7232,16 @@ + A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers. + FMA:83506 polychromatophilic erythroblast + + + + A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers. + ISBN:0721601464 + @@ -5234,8 +7282,16 @@ + The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated. + FMA:84646 orthochromatic erythroblast + + + + The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated. + ISBN:0721601464 + @@ -5397,9 +7453,22 @@ - + The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative). + BTO:0001164 + CALOHA:TS-0610 + FMA:84235 + MESH:D055016 + Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. megakaryocyte progenitor cell + + + + The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative). + GOC:dsd + GOC:tfm + ISBN:0721601464 + @@ -5420,9 +7489,22 @@ - + A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release. + BTO:0000843 + CALOHA:TS-0611 + FMA:83555 + Megakaryocytes are reportedly CD181-positive and CD182-positive. megakaryocyte + + + + A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release. + ISBN:0721601464 + MESH:D008533 + PMID:31043076 + http://en.wikipedia.org/wiki/Megakaryocyte + @@ -5514,9 +7596,27 @@ - + A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. + Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. granulocyte monocyte progenitor cell + + + + A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. + GOC:amm + GOC:dsd + GOC:tfm + GO_REF:0000031 + ISBN:0721601464 + MESH:D055014 + PMCID:PMC2213186 + PMCID:PMC548021 + PMID:16551251 + PMID:16647566 + http://en.wikipedia.org/wiki/CFU-GM + http://www.copewithcytokines.de + @@ -5667,8 +7767,21 @@ + An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. + BTO:0001173 + CALOHA:TS-0864 + MESH:D012156 reticulocyte + + + + An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. + GOC:add + GOC:tfm + PMID:15946868 + PMID:2037622 + @@ -5714,9 +7827,19 @@ - + A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules. + BTO:0004657 + FMA:83551 + Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. promonocyte + + + + A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules. + GOC:tfm + ISBN:0721601464 + @@ -5742,8 +7865,16 @@ + An erythrocyte having a nucleus. nucleate erythrocyte + + + + An erythrocyte having a nucleus. + GOC:add + GOc:tfm + @@ -5795,8 +7926,18 @@ + A mesenchymal stem cell capable of developing into blood vessel endothelium. + These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. angioblastic mesenchymal cell + + + + A mesenchymal stem cell capable of developing into blood vessel endothelium. + GOC:dsd + GOC:tfm + PMID:12768659 + @@ -5822,8 +7963,15 @@ + A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field. cardiac mesenchymal cell + + + + A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field. + PMID:18816864 + @@ -5837,9 +7985,18 @@ - + One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. + BTO:0001036 + CALOHA:TS-0866 + FMA:67748 retinal cone cell + + + + One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. + MESH:D017949 + @@ -5865,9 +8022,18 @@ - + An epithelial cell of the cornea. + BTO:0004298 + CALOHA:TS-0173 + FMA:70551 corneal epithelial cell + + + + An epithelial cell of the cornea. + GOC:tfm + @@ -5924,9 +8090,20 @@ - + Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells. + BTO:0000876 + CALOHA:TS-0638 + FMA:62864 + Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. monocyte + + + + Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells. + GO_REF:0000031 + MESH:D009000 + @@ -6030,15 +8207,42 @@ + + + + + + - + A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative. + BTO:0000802 + CALOHA:TS-0030 + FMA:83023 + A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8. + Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. alveolar macrophage + + + + A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative. + GOC:ana + GOC:dsd + GOC:tfm + GO_REF:0000031 + MESH:D016676 + + + + + A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8. + https://doi.org/10.5281/zenodo.11165918 + @@ -6052,8 +8256,19 @@ + The reproductive cell in multicellular organisms. + BTO:0000535 + NCIT:C12597 + VHOG:0001534 + WBbt:0006796 germ cell + + + + The reproductive cell in multicellular organisms. + MESH:D005854 + @@ -6078,8 +8293,15 @@ + A steroid hormone secreting cell that secretes androgen. androgen secreting cell + + + + A steroid hormone secreting cell that secretes androgen. + GOC:tfm + @@ -6093,9 +8315,44 @@ - + One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. + BTO:0001024 + CALOHA:TS-0870 + FMA:67747 retinal rod cell + + + + One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. + MESH:D017948 + + + + + + + + + + + + + + + + A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). + FMA:83625 + MESH:D061354 + acinar cell + + + + + A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). + GOC:tfm + http://www.copewithcytokines.de + @@ -6103,8 +8360,50 @@ + A cell whose primary function is to support other cell types. + BTO:0002315 supporting cell + + + + A cell whose primary function is to support other cell types. + FB:ma + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues. + fenestrated endothelial cell + + + + + An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues. + DOI:10.1007/978-3-211-99390-3_133 + @@ -6112,8 +8411,15 @@ + An extracellular matrix secreting cell that secretes collagen. collagen secreting cell + + + + An extracellular matrix secreting cell that secretes collagen. + GOC:tfm + @@ -6124,9 +8430,24 @@ - + An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. + BTO:0002441 + FMA:63174 + Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A. pericyte + + + + An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. + GOC:dsd + GOC:tfm + ISBN:0721662544 + MESH:D020286 + PMID:16807374 + PMID:17986482 + PMID:20024907 + @@ -6156,8 +8477,17 @@ + A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells. + FMA:70567 primordial germ cell + + + + A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells. + GOC:tfm + PMID:1381289 + @@ -6166,8 +8496,15 @@ + A mature sexual reproductive cell of the female germline. female gamete + + + + A mature sexual reproductive cell of the female germline. + GOC:tfm + @@ -6199,8 +8536,15 @@ + A non-terminally differentiated cell that is capable of developing into a muscle cell. muscle precursor cell + + + + A non-terminally differentiated cell that is capable of developing into a muscle cell. + GOC:add + @@ -6209,8 +8553,19 @@ + A cell that stores and secretes pancreatic polypeptide hormone. + FMA:62938 + FMA:83409 PP cell + + + + A cell that stores and secretes pancreatic polypeptide hormone. + GOC:tfm + JB:jb + PMID:15153415 + @@ -6236,8 +8591,18 @@ + Epithelial cells derived from neural plate and neural crest. + BTO:0004301 + FMA:70557 + The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). neurecto-epithelial cell + + + + Epithelial cells derived from neural plate and neural crest. + GOC:tfm + @@ -6262,8 +8627,17 @@ + A stem cell that can give rise to cell types of the body other than those of the germ-line. + CALOHA:TS-2086 + MESH:D053687 somatic stem cell + + + + A stem cell that can give rise to cell types of the body other than those of the germ-line. + GO:0048103 + @@ -6299,8 +8673,19 @@ + Muscle cell which has as its direct parts myofilaments organized into sarcomeres. + BTO:0002916 + CALOHA:TS-2157 + FMA:86936 striated muscle cell + + + + Muscle cell which has as its direct parts myofilaments organized into sarcomeres. + GOC:tfm + ISBN:0721662544 + @@ -6351,9 +8736,22 @@ - + An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + BTO:0000751 + CALOHA:TS-0549 + FMA:62852 + MESH:D007962 + NCIT:C12529 leukocyte + + + + An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + GOC:add + GOC:tfm + ISBN:978-0-323-05290-0 + @@ -6367,9 +8765,18 @@ - + The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve. + BTO:0001800 + FMA:67765 + MESH:D012165 retinal ganglion cell + + + + The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve. + GOC:dph + @@ -6419,9 +8826,24 @@ - + Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. + BTO:0001539 + CALOHA:TS-0115 + FMA:14067 + MESH:D032383 + This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. cardiac muscle cell + + + + Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. + GOC:mtg_cardiacconduct_nov11 + GOC:tfm + ISBN:0323052908 + PMID:22426062 + PMID:4711263 + @@ -6447,8 +8869,18 @@ + A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. + BTO:0001441 + CALOHA:TS-0647 + MESH:D022423 myeloid cell + + + + A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. + GOC:add + @@ -6456,9 +8888,20 @@ - + A immature or mature cell in the lineage leading to and including erythrocytes. + CALOHA:TS-0290 + FMA:62845 + FMA:83516 + Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. erythroid lineage cell + + + + A immature or mature cell in the lineage leading to and including erythrocytes. + GOC:add + GOC:tfm + @@ -6620,8 +9063,21 @@ + A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers. + BTO:0001571 + CALOHA:TS-0289 + FMA:83504 + MESH:D004900 erythroblast + + + + A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers. + GOC:add + ISBN:0721601464 + PMID:18174176 + @@ -6641,8 +9097,15 @@ + A cell of the monocyte, granulocyte, or mast cell lineage. myeloid leukocyte + + + + A cell of the monocyte, granulocyte, or mast cell lineage. + GOC:add + @@ -6662,8 +9125,21 @@ + A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts. + Morphology: mononuclear, highly vesicular. mononuclear osteoclast + + + + A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts. + GOC:add + GOC:tfm + PMID:12713016 + PMID:15055519 + PMID:17380158 + PMID:9415452 + @@ -6689,8 +9165,18 @@ + A specialized multinuclear osteoclast associated with the absorption and removal of bone. + Morphology: multinucleated, highly vesicular. multinuclear osteoclast + + + + A specialized multinuclear osteoclast associated with the absorption and removal of bone. + GOC:add + PMID:12713016 + PMID:9415452 + @@ -6726,8 +9212,20 @@ + A dendritic cell of the myeloid lineage. + BTO:0004721 + These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). myeloid dendritic cell + + + + A dendritic cell of the myeloid lineage. + GOC:add + PMID:10449155 + PMID:17332250 + PMID:9521319 + @@ -6747,8 +9245,16 @@ + A phagocyte formed by the fusion of mononuclear phagocytes. multinucleated phagocyte + + + + A phagocyte formed by the fusion of mononuclear phagocytes. + GOC:add + GOC:tfm + @@ -6779,8 +9285,16 @@ + A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage. pro-T cell + + + + A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage. + GOC:add + ISBN:0781735149 + @@ -6842,8 +9356,20 @@ + The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow. + BTO:0000187 + FMA:83524 myeloblast + + + + The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow. + GOC:add + ISBN:0721601464 + http://en.wikipedia.org/wiki/Myeloblast + http://www.cap.org + @@ -7016,9 +9542,20 @@ - + A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans. + BTO:0000725 + CALOHA:TS-0448 + Markers differ between mouse and human. hematopoietic multipotent progenitor cell + + + + A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans. + GOC:add + GOC:tfm + PMID:19022770 + @@ -7045,8 +9582,20 @@ + A progenitor cell restricted to the lymphoid lineage. + BTO:0004731 + CALOHA:TS-2025 + FMA:70338 + Note that this is a class of cell types, not an identified single cell type. lymphoid lineage restricted progenitor cell + + + + A progenitor cell restricted to the lymphoid lineage. + GOC:add + GOC:tfm + @@ -7072,9 +9621,21 @@ - + A progenitor cell restricted to the myeloid lineage. + BTO:0004730 + CALOHA:TS-2099 + FMA:70339 + Note that this is a class of cell types, not an identified single cell type. myeloid lineage restricted progenitor cell + + + + A progenitor cell restricted to the myeloid lineage. + GOC:add + GOC:tfm + PMID:19022770 + @@ -7094,8 +9655,18 @@ + A leukocyte with a single non-segmented nucleus in the mature form. + BTO:0000878 + CALOHA:TS-0768 + FMA:86713 mononuclear cell + + + + A leukocyte with a single non-segmented nucleus in the mature form. + GOC:add + @@ -7174,9 +9745,21 @@ - + A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes. + Markers: CCR2+CXCCR1<low> (human, mouse, rat). classical monocyte + + + + A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes. + GOC:add + GO_REF:0000031 + PMID:16322748 + PMID:18303997 + PMID:20628149 + PMID:20870168 + @@ -7237,8 +9820,22 @@ + A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive. + FMA:84643 + FMA:84645 + Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). elicited macrophage + + + + A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive. + GOC:add + GOC:ana + GOC:tfm + GO_REF:0000031 + PMID:15771589 + @@ -7263,8 +9860,18 @@ + A macrophage that suppresses immune responses. + Markers: May express: IL10, TGFbeta. suppressor macrophage + + + + A macrophage that suppresses immune responses. + GOC:add + GOC:tfm + PMID:20402419 + @@ -7289,8 +9896,19 @@ + A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. + FMA:84642 + FMA:84644 tissue-resident macrophage + + + + A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. + GOC:ana + GO_REF:0000031 + PMID:19770654 + @@ -7316,8 +9934,16 @@ + A tissue-resident macrophage found in the central nervous system. central nervous system macrophage + + + + A tissue-resident macrophage found in the central nervous system. + GO_REF:0000031 + PMID:16322748 + @@ -7393,9 +10019,21 @@ - + A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative. + Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. early lymphoid progenitor + + + + A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative. + GOC:add + GOC:dsd + GOC:pam + GOC:tfm + GO_REF:0000031 + PMID:19022770 + @@ -7403,8 +10041,20 @@ + A cell of a hematopoietic lineage. + BTO:0000574 + CALOHA:TS-2017 + FMA:70366 + FMA:83598 hematopoietic cell + + + + A cell of a hematopoietic lineage. + GOC:add + GO_REF:0000031 + @@ -7429,9 +10079,19 @@ - + Conventional dendritic cell is a dendritic cell that is CD11c-high. + FMA:84191 + Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. conventional dendritic cell + + + + Conventional dendritic cell is a dendritic cell that is CD11c-high. + GOC:amm + GO_REF:0000031 + PMID:17850486 + @@ -7447,6 +10107,7 @@ + Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617). CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor @@ -7556,8 +10217,21 @@ + A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative. + Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617). Kit and Sca1-positive hematopoietic stem cell + + + + A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative. + GOC:add + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:17952047 + PMID:19022770 + @@ -7573,6 +10247,7 @@ + Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor @@ -7590,6 +10265,7 @@ + Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). CD115-positive monocyte OR common dendritic progenitor @@ -7654,8 +10330,21 @@ + A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive. + These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617). CD34-positive, CD38-positive common lymphoid progenitor + + + + A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive. + GOC:add + GOC:amm + GOC:tfm + GO_REF:0000031 + PMCID:PMC2346585 + PMID:19022770 + @@ -7698,8 +10387,19 @@ + CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive. + These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). CD115-positive monocyte + + + + CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive. + GOC:add + GOC:amm + GO_REF:0000031 + PMID:17952047 + @@ -7772,8 +10472,22 @@ + A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low. + Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617). Kit-positive, CD34-positive common myeloid progenitor + + + + A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low. + GOC:add + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:1261582 + PMID:17952047 + http://www.immgen.org/index_content.html + @@ -7872,8 +10586,25 @@ + CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive. + CALOHA:TS-0448 + Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617). CD34-positive, CD38-negative hematopoietic stem cell + + + + CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive. + GOC:add + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:10430905 + PMID:11750107 + PMID:16551251 + PMID:20024907 + PMID:9389721 + @@ -7965,8 +10696,21 @@ + A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low. + Markers are associated with mouse cells. Kit-positive, Sca1-positive common lymphoid progenitor + + + + A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low. + GOC:add + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:17952047 + http://www.immgen.org/index_content.html + @@ -8048,8 +10792,20 @@ + A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative. + Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617). CD34-positive, CD38-positive common myeloid progenitor + + + + A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative. + GOC:add + GOC:amm + GO_REF:0000031 + PMCID:PMC2626675 + PMID:16551251 + @@ -8101,8 +10857,18 @@ + CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative. + These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617). CD7-negative lymphoid progenitor cell + + + + CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative. + GOC:amm + GO_REF:0000031 + PMID:16551251 + @@ -8153,8 +10919,20 @@ + CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative. + These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). CD7-positive lymphoid progenitor cell + + + + CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative. + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:16551251 + PMID:19491395 + @@ -8326,8 +11104,21 @@ + Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers. + Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). common dendritic progenitor + + + + Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers. + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:16551251 + PMID:17922016 + PMID:19286519 + @@ -8343,6 +11134,7 @@ + Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617). CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor @@ -8369,9 +11161,16 @@ - + A connective tissue cell found in bone. bone cell + + + + A connective tissue cell found in bone. + GOC:add + GO_REF:0000034 + @@ -8426,9 +11225,17 @@ - + A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20. + This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. CD14-positive monocyte + + + + A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20. + GOC:add + PMID:22343568 + @@ -8508,8 +11315,23 @@ + A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1. + CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. common myeloid progenitor, CD34-positive + + + + A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1. + GOC:add + GOC:dsd + GOC:tfm + ISBN:0878932437 + PMCID:PMC2212039 + PMID:10724173 + PMID:16551251 + PMID:16647566 + @@ -8648,8 +11470,16 @@ + A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. hematopoietic oligopotent progenitor cell, lineage-negative + + + + A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. + GOC:tfm + PMID:19022770 + @@ -8794,8 +11624,17 @@ + A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative). + BTO:0004911 erythroid progenitor cell, mammalian + + + + A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative). + GOC:add + ISBN:0721601464 + @@ -8896,8 +11735,19 @@ + An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative. + Markers found on mouse cells. Kit-positive erythroid progenitor cell + + + + An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative. + GOC:ak + GOC:tfm + PMID:19805084 + http://www.immgen.org/index_content.html + @@ -8942,8 +11792,18 @@ + A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative. + Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. CD34-positive, CD38-positive granulocyte monocyte progenitor + + + + A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative. + GOC:tfm + PMID:12615892 + PMID:19022770 + @@ -9044,8 +11904,21 @@ + A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative. + Markers are found on mouse cells. Kit-positive granulocyte monocyte progenitor + + + + A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative. + GOC:tfm + PMID:12615892 + PMID:16322423 + PMID:19022770 + PMID:19273628 + http://www.immgen.org/index_content.html + @@ -9086,8 +11959,19 @@ + An erythroid progenitor cell that is CD34-positive and is GlyA-negative. + FMA:83517 + Cell markers associated with human cells. CD34-positive, GlyA-negative erythroid progenitor cell + + + + An erythroid progenitor cell that is CD34-positive and is GlyA-negative. + GOC:ak + GOC:tfm + PMID:19621348 + @@ -9128,8 +12012,18 @@ + A proerythoblast that is CD34-negative and GlyA-negative. + Cell surface markers are associated with human cells. CD34-negative, GlyA-negative proerythroblast + + + + A proerythoblast that is CD34-negative and GlyA-negative. + GOC:ak + GOC:tfm + PMID:19621348 + @@ -9184,8 +12078,18 @@ + A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative. + Markers are associated with human cell type. CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell + + + + A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative. + GOC:tfm + PMID:12615892 + PMID:190227700 + @@ -9270,8 +12174,19 @@ + A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low. + Markers are associated with mouse cells. Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell + + + + A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low. + GOC:tfm + PMID:12615892 + PMID:19022770 + http://www.immgen.org/index_content.html + @@ -9314,8 +12229,16 @@ + A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. macrophage dendritic cell progenitor + + + + A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. + GOC:tfm + PMID:19273628 + @@ -9497,8 +12420,15 @@ + A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha. pre-conventional dendritic cell + + + + A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha. + GOC:tfm + @@ -9559,8 +12489,17 @@ + A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative. + Markers are associated with mouse cells. Kit-positive macrophage dendritic cell progenitor + + + + A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative. + GOC:tfm + PMID:19273628 + @@ -9631,8 +12570,18 @@ + A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive. + Markers are associated with mouse cells. Kit-low proerythroblast + + + + A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive. + GOC:ak + GOC:tfm + PMID:19805084 + @@ -9673,8 +12622,18 @@ + A basophilic erythroblast that is GlyA-positive. + Markers are associated with human cells. GlyA-positive basophilic erythroblast + + + + A basophilic erythroblast that is GlyA-positive. + GOC:ak + GOC:tfm + PMID:1638021 + @@ -9735,8 +12694,18 @@ + A basophilic erythroblast that is Lyg 76-high and is Kit-negative. + Cell surface markers are associated with mouse cells. Kit-negative, Ly-76 high basophilic erythroblast + + + + A basophilic erythroblast that is Lyg 76-high and is Kit-negative. + GOC:ak + GOC:tfm + PMID:19805084 + @@ -9797,8 +12766,17 @@ + A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative. Kit-negative, Ly-76 high polychromatophilic erythroblast + + + + A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative. + GOC:ak + GOC:tfm + PMID:19805084 + @@ -9839,8 +12817,18 @@ + A polychromatiic erythroblast that is Gly-A-positive and CD71-low. + Cell surface markers are associated with human cells. CD71-low, GlyA-positive polychromatic erythroblast + + + + A polychromatiic erythroblast that is Gly-A-positive and CD71-low. + GOC:ak + GOC:tfm + PMID:1638021 + @@ -9911,8 +12899,18 @@ + An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative. + Cell surface markers associated with mouse cells. Kit-negative, Ly-76 high orthochromatophilic erythroblasts + + + + An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative. + GOC:ak + GOC:tfm + PMID:19805084 + @@ -9953,8 +12951,18 @@ + An erythroblast that is GlyA-positive and CD71-negative. + Markers associated with human cells. CD71-negative, GlyA-positive orthochromatic erythroblast + + + + An erythroblast that is GlyA-positive and CD71-negative. + GOC:ak + GOC:tfm + PMID:1638021 + @@ -9987,8 +12995,16 @@ + A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. hematopoietic lineage restricted progenitor cell + + + + A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. + GOC:tfm + PMID:19022770 + @@ -10020,8 +13036,18 @@ + A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. + This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). hematopoietic oligopotent progenitor cell + + + + A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. + GOC:tfm + PMID:19022770 + https://orcid.org/0000-0001-5208-3432 + @@ -10066,8 +13092,18 @@ + A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative. + Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low. short term hematopoietic stem cell + + + + A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative. + GOC:tfm + PMID:15572596 + PMID:19022770 + @@ -10116,8 +13152,18 @@ + A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative. + Markers are associated with mouse cells. long term hematopoietic stem cell + + + + A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative. + GOC:tfm + PMID:15572596 + PMID:17582345 + @@ -10178,8 +13224,17 @@ + A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative. + Markers are associated with mouse cells. Slamf1-negative multipotent progenitor cell + + + + A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative. + GOC:tfm + PMID:19022770 + @@ -10231,8 +13286,17 @@ + A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive. + Markers are associated with mouse cells. Slamf1-positive multipotent progenitor cell + + + + A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive. + GOC:tfm + PMID:19022770 + @@ -10287,8 +13351,18 @@ + A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative. + Cell markers are associated with human hematopoietic multipotent progenitor cells. CD34-positive, CD38-negative multipotent progenitor cell + + + + A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative. + GOC:tfm + PMID:18371405 + PMID:19022770 + @@ -10313,9 +13387,20 @@ - + A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange. + BTO:0000780 + FMA:62500 pulmonary alveolar type 1 cell + + + + A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange. + GOC:tfm + PMID:20054144 + PMID:29463737 + http://www.copewithcytokines.de + @@ -10346,9 +13431,67 @@ - + A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli. + BTO:0000538 + FMA:62501 pulmonary alveolar type 2 cell + + + + A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli. + GOC:tfm + ISBN:0412046911 + PMID:36138472 + PMID:8540632 + http://www.copewithcytokines.de + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules. + BTO:0000028 + CALOHA:TS-0737 + FMA:63032 + pancreatic acinar cell + + + + + A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules. + GOC:tfm + ISBN:0517223651 + PMID:20395539 + http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells + @@ -10368,8 +13511,17 @@ + An enteroendocrine cell that produces glucagon. + FMA:62939 type A enteroendocrine cell + + + + An enteroendocrine cell that produces glucagon. + GOC:tfm + ISBN:0412046911 + @@ -10377,9 +13529,19 @@ - + Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter. + BTO:0001032 + FMA:14146 Purkinje myocyte + + + + Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter. + FMA:0412046911 + GOC:tfm + PMID:19939742 + @@ -10387,8 +13549,18 @@ + A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery. + BTO:0004190 + FMA:67101 nodal myocyte + + + + A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery. + FMA:67101 + GOC:tfm + @@ -10396,8 +13568,17 @@ + Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes. + FMA:67142 transitional myocyte + + + + Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes. + FMA:67142 + GOC:tfm + @@ -10406,8 +13587,17 @@ + The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides). + FMA:67111 myocardial endocrine cell + + + + The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides). + FMA:67111 + GOC:tfm + @@ -10433,8 +13623,17 @@ + An epithelial cell derived from endoderm. + FMA:69075 endo-epithelial cell + + + + An epithelial cell derived from endoderm. + FMA:69075 + GOC:tfm + @@ -10460,8 +13659,17 @@ + An epithelial cell derived from ectoderm. + FMA:69074 ecto-epithelial cell + + + + An epithelial cell derived from ectoderm. + FMA:69074 + GOC:tfm + @@ -10487,8 +13695,111 @@ + Epithelial cell derived from mesoderm or mesenchyme. + FMA:69076 meso-epithelial cell + + + + Epithelial cell derived from mesoderm or mesenchyme. + FMA:69076 + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH. + FMA:63099 + pancreatic ductal cell + + + + + Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH. + FMA:63099 + GOC:tfm + PMID:14740223 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types. + FMA:62455 + pancreatic centro-acinar cell + + + + + A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types. + GOC:tfm + PMID:12142741 + PMID:20018761 + PMID:8185160 + @@ -10496,8 +13807,17 @@ + A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart. + FMA:67968 specialized cardiac myocyte + + + + A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart. + FMA:67968 + GOC:tfm + @@ -10522,8 +13842,54 @@ + A leukocyte that lacks granules. + FMA:62855 nongranular leukocyte + + + + A leukocyte that lacks granules. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise. + BTO:0003914 + FMA:86573 + Some argue this cell type is of mesenchymal origin. + interstitial cell of Cajal + + + + + This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise. + GOC:tfm + PMID:16460275 + PMID:19520112 + @@ -10548,8 +13914,20 @@ + A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. + BTO:0004850 + FMA:83621 + MESH:D001854 + MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. bone marrow cell + + + + A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. + GOC:tfm + ISBN:0618947256 + @@ -10558,9 +13936,17 @@ - + A cell in the hilum of the ovary that produces androgens. + FMA:18710 hilus cell of ovary + + + + A cell in the hilum of the ovary that produces androgens. + GOC:tfm + ISBN:068340007X + @@ -10585,8 +13971,16 @@ + A stomal cell of the ovary + FMA:72299 stromal cell of ovary + + + + A stomal cell of the ovary + GOC:tfm + @@ -10594,8 +13988,21 @@ + An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. + BTO:0001854 + CALOHA:TS-1106 + FMA:67755 + These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. endothelial cell of vascular tree + + + + An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. + GOC:dsd + GOC:tfm + PMID:12768659 + @@ -10621,9 +14028,18 @@ - + An endothelial cell found in capillaries. + BTO:0004956 + CALOHA:TS-0112 + FMA:67756 capillary endothelial cell + + + + An endothelial cell found in capillaries. + GOC:tfm + @@ -10639,9 +14055,17 @@ - + A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree. + FMA:70542 ciliated columnar cell of tracheobronchial tree + + + + A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree. + GOC:tfm + ISBN:0517223651 + @@ -10649,8 +14073,16 @@ + Epithelial cells derived from general body ectoderm and ectoderm placodes. + FMA:70556 general ecto-epithelial cell + + + + Epithelial cells derived from general body ectoderm and ectoderm placodes. + GOC:tfm + @@ -10675,8 +14107,16 @@ + An epithelial cell found in the lining of the stomach. + FMA:62948 epithelial cell of stomach + + + + An epithelial cell found in the lining of the stomach. + GOC:tfm + @@ -10701,8 +14141,16 @@ + A mucous cell in the epithelium of the stomach. + FMA:63464 mucous cell of stomach + + + + A mucous cell in the epithelium of the stomach. + GOC:tfm + @@ -10729,8 +14177,17 @@ + A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit. + FMA:62953 stem cell of gastric gland + + + + A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit. + GOC:tfm + ISBN:0517223651 + @@ -10755,8 +14212,16 @@ + A cell involved in the formation of a granulocyte. + FMA:83519 granulocytopoietic cell + + + + A cell involved in the formation of a granulocyte. + GOC:tfm + @@ -10781,8 +14246,51 @@ + A cell involved in the formation of a monocyte (monopoiesis). + FMA:83552 monopoietic cell + + + + A cell involved in the formation of a monocyte (monopoiesis). + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes). + FMA:86577 + hepatic stem cell + + + + + A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes). + GOC:tfm + PMID:26798363 + @@ -10807,8 +14315,16 @@ + An epithelial cell of the tracheobronchial tree. + FMA:66816 epithelial cell of tracheobronchial tree + + + + An epithelial cell of the tracheobronchial tree. + GOC:tfm + @@ -10816,8 +14332,17 @@ + An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells. + FMA:69060 intermediate epitheliocyte + + + + An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells. + GOC:tfm + ISBN:0517223651 + @@ -10832,8 +14357,17 @@ + A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye. + FMA:70950 vertebrate lens cell + + + + A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye. + GOC:tfm + ISBN:0721662544 + @@ -10859,9 +14393,18 @@ - + A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. + FMA:67559 lens epithelial cell + + + + A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. + GOC:tfm + ISBN:0721662544 + http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium + @@ -10881,8 +14424,16 @@ + A fibroblast in the bone marrow. + FMA:84377 marrow fibroblast + + + + A fibroblast in the bone marrow. + GOC:tfm + @@ -10912,8 +14463,16 @@ + A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis. + FMA:84467 pulmonary interstitial fibroblast + + + + A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis. + GOC:tfm + @@ -10938,8 +14497,58 @@ + A cell containing at least one nucleus. + FMA:67513 nucleate cell + + + + A cell containing at least one nucleus. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells. + FMA:70611 + smooth muscle cell of sphincter of pupil + + + + + A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells. + GOC:tfm + ISBN:0721662544 + ISBN:0721694128 + @@ -10965,8 +14574,18 @@ + A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells). + BTO:0002669 + FMA:86711 + MESH:D000072916 peripheral blood stem cell + + + + A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells). + GOC:tfm + @@ -10991,8 +14610,16 @@ + An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. epithelial cell of alimentary canal + + + + An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. + GOC:tfm + ISBN:0721662544 + @@ -11017,8 +14644,85 @@ + An epithelial cell of the esophagus. + FMA:63071 epithelial cell of esophagus + + + + An epithelial cell of the esophagus. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the large intestine. + BTO:0004297 + FMA:256157 + epithelial cell of large intestine + + + + + An epithelial cell of the large intestine. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the small intestine. + FMA:256159 + epithelial cell of small intestine + + + + + An epithelial cell of the small intestine. + GOC:tfm + @@ -11043,9 +14747,17 @@ - + An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver. + FMA:63134 endothelial cell of sinusoid + + + + An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver. + GOC:tfm + ISBN:0618947256 + @@ -11065,8 +14777,145 @@ + A type of enteroendocrine cell found in the stomach that secretes glucagon. + FMA:83411 type A cell of stomach + + + + A type of enteroendocrine cell found in the stomach that secretes glucagon. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + A D cell located in the colon. + FMA:268744 + type D cell of colon + + + + + A D cell located in the colon. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + A type D cell of the small intestine. + FMA:268736 + type D cell of small intestine + + + + + A type D cell of the small intestine. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + A type D cell found in the stomach. + FMA:83410 + type D cell of stomach + + + + + A type D cell found in the stomach. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A PP cell located in the islets of the pancreas. + BTO:0000805 + FMA:70588 + MESH:D050418 + The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. + pancreatic PP cell + + + + + A PP cell located in the islets of the pancreas. + GOC:tfm + @@ -11091,8 +14940,16 @@ + An epithelial cell of a skin gland. + FMA:70657 epithelial cell of skin gland + + + + An epithelial cell of a skin gland. + GOC:tfm + @@ -11117,8 +14974,18 @@ + A cell that is part of the nervous system. + CALOHA:TS-2040 + FMA:70333 neural cell + + + + A cell that is part of the nervous system. + GOC:tfm + ISBN:0618947256 + @@ -11143,8 +15010,19 @@ + A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. + CALOHA:TS-2096 + FMA:63875 + MESH:D003239 connective tissue cell + + + + A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. + GOC:tfm + ISBN:0618947256 + @@ -11152,8 +15030,18 @@ + A cell of the embryo. + CALOHA:TS-0263 + FMA:82840 + WBbt:0007028 embryonic cell (metazoa) + + + + A cell of the embryo. + FMA:0618947256 + @@ -11178,8 +15066,16 @@ + An epithelial cell of the bronchus. + BTO:0002922 bronchial epithelial cell + + + + An epithelial cell of the bronchus. + GOC:tfm + @@ -11199,9 +15095,16 @@ - + A ciliated cell of the bronchus. ciliated cell of the bronchus + + + + A ciliated cell of the bronchus. + GOC:tfm + PMID:18757316 + @@ -11232,8 +15135,16 @@ + An adipocyte derived from a neural crest cell. neural crest derived adipocyte + + + + An adipocyte derived from a neural crest cell. + GOC:tfm + PMID:17507398 + @@ -11258,9 +15169,36 @@ - + An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin. + FMA:75621 endocardial cell + + + + An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin. + GOC:tfm + ISSN:0452-3458 + + + + + + + + + A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1. + progenitor cell of endocrine pancreas + + + + + A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1. + GOC:tfm + PMID:20025937 + PMID:20217494 + PMID:22728667 + @@ -11285,8 +15223,16 @@ + A hematopoietic stem cell that exists during embryogenesis. gestational hematopoietic stem cell + + + + A hematopoietic stem cell that exists during embryogenesis. + GOC:tfm + ISBN:978-60327-246-6 + @@ -11311,9 +15257,16 @@ - + A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate. keratocyte + + + + A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate. + GOC:tfm + ISBN:9780702029585 + @@ -11338,8 +15291,16 @@ + An endo-epithelial cell of the respiratory tract. + BTO:0004533 respiratory epithelial cell + + + + An endo-epithelial cell of the respiratory tract. + GOC:tfm + @@ -11373,8 +15334,18 @@ + A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. myotube + + + + A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. + GOC:dos + GOC:tfm + ISBN:0323052908 + PMID:22274696 + @@ -11409,8 +15380,19 @@ + A CD14-positive monocyte that is also CD16-positive and CCR2-negative. + This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+). CD14-positive, CD16-positive monocyte + + + + A CD14-positive monocyte that is also CD16-positive and CCR2-negative. + GOC:tfm + PMID:20628149 + PMID:21937707 + PMID:22343568 + @@ -11430,8 +15412,18 @@ + A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles. nucleated reticulocyte + + + + A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles. + GOC:tfm + PMID:18182572 + PMID:9011180 + PMID:9046052 + @@ -11466,8 +15458,16 @@ + Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive. Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell + + + + Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive. + GOC:tfm + http://www.immgen.org/index_content.html + @@ -11510,8 +15510,16 @@ + A F4/80-negative dendritic cell located in adipose tissue. adipose dendritic cell + + + + A F4/80-negative dendritic cell located in adipose tissue. + GOC:tfm + http://www.immgen.org/index_content.html + @@ -11536,8 +15544,16 @@ + An adipose dendritic cell that is SIRPa-positive. SIRPa-positive adipose dendritic cell + + + + An adipose dendritic cell that is SIRPa-positive. + GOC:tfm + http://www.immgen.org/index_content.html + @@ -11562,8 +15578,16 @@ + An adipose dendritic cell that is SIRPa-negative. SIRPa-negative adipose dendritic cell + + + + An adipose dendritic cell that is SIRPa-negative. + GOC:tfm + http://www.immgen.org/index_content.html + @@ -11588,8 +15612,16 @@ + A conventional dendritic cell that expresses CD11b (ITGAM). CD11b-positive dendritic cell + + + + A conventional dendritic cell that expresses CD11b (ITGAM). + GOC:tfm + http://www.immgen.org/index_content.html + @@ -11614,8 +15646,20 @@ + A cell located in the heart, including both muscle and non muscle cells. + BTO:0001539 + CALOHA:TS-0115 + FMA:83808 + FMA:84791 + From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. cardiocyte + + + + A cell located in the heart, including both muscle and non muscle cells. + GOC:tfm + @@ -11641,8 +15685,50 @@ + A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc + BTO:0002441 + FMA:84639 adventitial cell + + + + A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell of the intestine. + enteric smooth muscle cell + + + + + A smooth muscle cell of the intestine. + GOC:tfm + @@ -11667,9 +15753,49 @@ - + An adipocyte that is part of subcutaneous adipose tissue. subcutaneous adipocyte + + + + An adipocyte that is part of subcutaneous adipose tissue. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes. + intrahepatic cholangiocyte + + + + + An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes. + GOC:tfm + PMID:23720296 + @@ -11694,8 +15820,16 @@ + A smooth muscle cell of the aorta. + BTO:0004577 aortic smooth muscle cell + + + + A smooth muscle cell of the aorta. + GOC:tfm + @@ -11715,8 +15849,15 @@ + A mesenchymal stem cell that is part of the bone marrow. mesenchymal stem cell of the bone marrow + + + + A mesenchymal stem cell that is part of the bone marrow. + GOC:tfm + @@ -11741,9 +15882,17 @@ - + An endothelial cell that is part of the vein. + FMA:62104 + KUPO:0001099 vein endothelial cell + + + + An endothelial cell that is part of the vein. + GOC:tfm + @@ -11751,8 +15900,16 @@ + An endothelial progenitor cell that participates in angiogenesis during development. + See CL:0002619. embryonic blood vessel endothelial progenitor cell + + + + An endothelial progenitor cell that participates in angiogenesis during development. + GOC:tfm + @@ -11777,8 +15934,15 @@ + A fibroblast of the aortic adventitia. fibroblast of the aortic adventitia + + + + A fibroblast of the aortic adventitia. + GOC:tfm + @@ -11804,8 +15968,15 @@ + A fibroblast that is part of the heart. fibroblast of cardiac tissue + + + + A fibroblast that is part of the heart. + GOC:tfm + @@ -11830,8 +16001,15 @@ + Any skin fibroblast that is part of some dermis. fibroblast of dermis + + + + Any skin fibroblast that is part of some dermis. + FBC:Autogenerated + @@ -11856,8 +16034,17 @@ + A fibroblast that is part of lung. + BTO:0000764 + CALOHA:TS-0575 fibroblast of lung + + + + A fibroblast that is part of lung. + GOC:tfm + @@ -11882,9 +16069,48 @@ - + A fibroblast of pulmonary artery. fibroblast of pulmonary artery + + + + A fibroblast of pulmonary artery. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the intestine. + intestinal epithelial cell + + + + + An epithelial cell of the intestine. + GOC:tfm + @@ -11909,8 +16135,110 @@ + A mesenchymal stem cell of adipose tissue. mesenchymal stem cell of adipose tissue + + + + A mesenchymal stem cell of adipose tissue. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + A mesenchymal stem cell of liver. + hepatic mesenchymal stem cell + + + + + A mesenchymal stem cell of liver. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + A mesenchymal stem cell of the vertebrae. + vertebral mesenchymal stem cell + + + + + A mesenchymal stem cell of the vertebrae. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A stromal cell of the pancreas. + stromal cell of pancreas + + + + + A stromal cell of the pancreas. + GOC:tfm + @@ -11936,8 +16264,15 @@ + A pericyte of the central nervous system. central nervous system pericyte + + + + A pericyte of the central nervous system. + GOC:tfm + @@ -11963,9 +16298,15 @@ - + A blood vessel endothelial cell that is part of the retina. retinal blood vessel endothelial cell + + + + A blood vessel endothelial cell that is part of the retina. + GOC:tfm + @@ -11990,8 +16331,15 @@ + A smooth muscle cell of the bachiocephalic vasculature. smooth muscle cell of the brachiocephalic vasculature + + + + A smooth muscle cell of the bachiocephalic vasculature. + GOC:tfm + @@ -12017,8 +16365,15 @@ + A vascular associated smooth muscle cell of the brain vasculature. smooth muscle cell of the brain vasculature + + + + A vascular associated smooth muscle cell of the brain vasculature. + GOC:tfm + @@ -12043,9 +16398,16 @@ - + A smooth muscle of the pulmonary artery. + BTO:0003336 smooth muscle cell of the pulmonary artery + + + + A smooth muscle of the pulmonary artery. + GOC:tfm + @@ -12070,8 +16432,15 @@ + A smooth muscle cell of the subclavian artery. smooth muscle cell of the subclavian artery + + + + A smooth muscle cell of the subclavian artery. + GOC:tfm + @@ -12096,8 +16465,15 @@ + Smooth muscle cell of the carotid artery. smooth muscle cell of the carotid artery + + + + Smooth muscle cell of the carotid artery. + GOC:tfm + @@ -12122,9 +16498,16 @@ - + Any smooth muscle cell that is part of some bronchus. + BTO:0004402 bronchial smooth muscle cell + + + + Any smooth muscle cell that is part of some bronchus. + FBC:Autogenerated + @@ -12149,8 +16532,15 @@ + A smooth muscle cell of the esophagus. smooth muscle cell of the esophagus + + + + A smooth muscle cell of the esophagus. + GOC:tfm + @@ -12175,8 +16565,15 @@ + A smooth muscle cell of the trachea. smooth muscle cell of trachea + + + + A smooth muscle cell of the trachea. + GOC:tfm + @@ -12202,8 +16599,15 @@ + A neuron of the raphe nuclei. raphe nuclei neuron + + + + A neuron of the raphe nuclei. + GOC:tfm + @@ -12229,8 +16633,15 @@ + A neuron of the ventral spinal cord. neuron of the ventral spinal cord + + + + A neuron of the ventral spinal cord. + GOC:tfm + @@ -12255,9 +16666,17 @@ - + A fibroblast of skin. + BTO:0001255 + CALOHA:TS-0935 skin fibroblast + + + + A fibroblast of skin. + GOC:tfm + @@ -12282,8 +16701,15 @@ + Any epithelial cell that is part of some lower respiratory tract epithelium. epithelial cell of lower respiratory tract + + + + Any epithelial cell that is part of some lower respiratory tract epithelium. + FBC:Autogenerated + @@ -12291,8 +16717,15 @@ + A squamous shaped endothelial cell. squamous endothelial cell + + + + A squamous shaped endothelial cell. + GOC:dos + @@ -12312,8 +16745,45 @@ + A glandular epithelial cell of the esophagus. + FMA:86548 glandular cell of esophagus + + + + A glandular epithelial cell of the esophagus. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + A glandular epithelial cell of the large intestine. + FMA:87194 + glandular cell of the large intestine + + + + + A glandular epithelial cell of the large intestine. + GOC:tfm + @@ -12333,8 +16803,17 @@ + A glandular epithelial cell that is part of the stomach. + CALOHA:TS-1284 + FMA:86554 glandular cell of stomach + + + + A glandular epithelial cell that is part of the stomach. + GOC:tfm + @@ -12359,8 +16838,16 @@ + A myocardial endocrine cell that is part of the atrium. + FMA:83389 myocardial endocrine cell of atrium + + + + A myocardial endocrine cell that is part of the atrium. + GOC:tfm + @@ -12368,8 +16855,17 @@ + A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart. + Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. cardioblast + + + + A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart. + GOC:tfm + PMID:19745164 + @@ -12384,8 +16880,17 @@ + A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. retinal progenitor cell + + + + A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. + GOC:tfm + PMID:20959166 + PMID:21148186 + @@ -12400,8 +16905,46 @@ + A neuroblast derived from a neural crest cell. neural crest derived neuroblast + + + + A neuroblast derived from a neural crest cell. + GOC:tfm + PMID:17407019 + + + + + + + + + + + + + + + + + + + + + A PP cell found in intestine. + PP cell of intestine + + + + + A PP cell found in intestine. + GOC:tfm + PMID:2420136 + PMID:728970 + @@ -12426,8 +16969,16 @@ + A CNS interneuron located in the spinal cord. + Is_a interneuron, part_of UBERON:0002240. spinal cord interneuron + + + + A CNS interneuron located in the spinal cord. + CL:CVS + @@ -12435,8 +16986,35 @@ + A ciliated epithelial cell with many cilia. multi-ciliated epithelial cell + + + + A ciliated epithelial cell with many cilia. + CL:CVS + + + + + + + + + Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation. + hepatoblast + + + + + Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation. + GOC:CVS + PMID:18356246 + PMID:20483998 + PMID:26798363 + https://orcid.org/0000-0003-1940-6740 + @@ -12444,8 +17022,16 @@ + Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized). + Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) skeletogenic cell + + + + Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized). + GO_REF:0000034 + @@ -12466,8 +17052,15 @@ + Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. premigratory neural crest cell + + + + Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. + UBERONREF:0000002 + @@ -12475,8 +17068,15 @@ + Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells. prechondroblast + + + + Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells. + GO_REF:0000034 + @@ -12484,8 +17084,15 @@ + Any muscle cell in which the fibers are not organised into sarcomeres. non-striated muscle cell + + + + Any muscle cell in which the fibers are not organised into sarcomeres. + GOC:DOS + @@ -12493,8 +17100,15 @@ + Any hematopoietic cell that is a precursor of some other hematopoietic cell type. hematopoietic precursor cell + + + + Any hematopoietic cell that is a precursor of some other hematopoietic cell type. + GOC:dos + @@ -12532,8 +17146,17 @@ + A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + MESH:D018485 skeletal muscle fiber + + + + A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:tfm + ISBN:0323052908 + @@ -12558,8 +17181,15 @@ + A muscle cell that is part of some visceral muscle. visceral muscle cell + + + + A muscle cell that is part of some visceral muscle. + GOC:dos + @@ -12587,8 +17217,15 @@ + A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods. striated visceral muscle cell + + + + A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods. + GOC:dos + @@ -12621,8 +17258,15 @@ + A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods. transversely striated visceral muscle cell + + + + A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods. + GOC:dos + @@ -12646,8 +17290,16 @@ + A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers. + The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins. adult skeletal muscle myoblast + + + + A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers. + PMID:23303905 + @@ -12668,7 +17320,6 @@ A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration. - mesenchymal cell @@ -12696,8 +17347,43 @@ + A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves. endocardial cushion cell + + + + A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves. + PMID:18816864 + + + + + + + + + + + + + + + + + + + + + An endocrine cell that is part of the pancreas. + pancreatic endocrine cell + + + + + An endocrine cell that is part of the pancreas. + GOC:dos + @@ -12722,8 +17408,15 @@ + Any neuron that is capable of part of some visual perception. visual system neuron + + + + Any neuron that is capable of part of some visual perception. + FBC:Autogenerated + @@ -12731,9 +17424,15 @@ - + Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation. mural cell + + + + Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation. + Wiki:Mural_cell&oldid=930603194 + @@ -12759,8 +17458,15 @@ + Any vascular associated smooth muscle cell that is part of some microcirculatory vessel. microcirculation associated smooth muscle cell + + + + Any vascular associated smooth muscle cell that is part of some microcirculatory vessel. + FBC:Autogenerated + @@ -12785,8 +17491,16 @@ + A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord. sensory neuron of spinal nerve + + + + A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord. + GOC:nv + GOC:pr + @@ -12832,6 +17546,8 @@ Any cell in the compound eye, a light sensing organ composed of ommatidia. + GOC:pr + PMID:12021768 compound eye retinal cell @@ -12858,8 +17574,503 @@ + Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + PMID:10702418 retinal cell + + + + Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + GOC:pr + + + + + + + + + + + + + + + + + + + + + An enteroendocrine cell that is located in the small intestine. + enteroendocrine cell of small intestine + + + + + An enteroendocrine cell that is located in the small intestine. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A lymphocyte that resides in the lamina propria of the large intestine. + This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. + lymphocyte of large intestine lamina propria + + + + + A lymphocyte that resides in the lamina propria of the large intestine. + https://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A stromal cell found in the lamina propria of the large intestine. + stromal cell of lamina propria of large intestine + + + + + A stromal cell found in the lamina propria of the large intestine. + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A stromal cell found in the lamina propria of the small intestine. + stromal cell of lamina propria of small intestine + + + + + A stromal cell found in the lamina propria of the small intestine. + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + A mesothelial cell that is part of the small intestine. + mesothelial cell of small intestine + + + + + A mesothelial cell that is part of the small intestine. + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + A mesothelial cell that is part of the colon. + mesothelial cell of colon + + + + + A mesothelial cell that is part of the colon. + http://orcid.org/0000-0003-3440-1876 + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A macrophage that is located in the colon. + This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. + colon macrophage + + + + + A macrophage that is located in the colon. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A stromal cell found in the lamina propria of the colon. + stromal cell of lamina propria of colon + + + + + A stromal cell found in the lamina propria of the colon. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + An enteroendocrine cell that is located in the colon. + enteroendocrine cell of colon + + + + + An enteroendocrine cell that is located in the colon. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response. + This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. + lymphocyte of small intestine lamina propria + + + + + A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response. + PMID:26551552 + https://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A macrophage that is located in the anorectum. + This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. + anorectum macrophage + + + + + A macrophage that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A T cell that is located in the anorectum. + This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. + T cell of anorectum + + + + + A T cell that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is located in the anorectum. + smooth muscle cell of anorectum + + + + + A smooth muscle cell that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A stromal cell found in the lamina propria of the anorectum. + stromal cell of anorectum lamina propria + + + + + A stromal cell found in the lamina propria of the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + + An enteroendocrine cell that is located in the anorectum. + enteroendocrine cell of anorectum + + + + + An enteroendocrine cell that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + @@ -12884,9 +18095,53 @@ - + A pericyte cell that is part of a lung. + EFO:0010669 lung pericyte + + + + A pericyte cell that is part of a lung. + https://orcid.org/0000-0003-3440-1876 + https://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell that is part of a hepatic portal vein. + EFO:0010704 + endothelial cell of hepatic portal vein + + + + + An endothelial cell that is part of a hepatic portal vein. + PMID:30348985 + https://orcid.org/0000-0003-3440-1876 + https://orcid.org/0000-0003-4183-8865 + @@ -12911,8 +18166,52 @@ + A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development. embryonic skeletal muscle fiber + + + + A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development. + PMID:32094117 + PMID:7196501 + http://orcid.org/0000-0003-2034-601X + + + + + + + + + + + + + + + + + + + + + + + + + + A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen. + hepatic portal fibroblast + + + + + A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen. + PMID:20209607 + PMID:24814904 + https://orcid.org/0000-0001-7655-4833 + @@ -12960,6 +18259,8 @@ An epithelial cell that is part_of a alveolus of lung. + MESH:D056809 + May be merged with pneumocyte in future epithelial cell of alveolus of lung @@ -13003,8 +18304,15 @@ + Any blood vessel endothelial cell that is part of some heart. cardiac blood vessel endothelial cell + + + + Any blood vessel endothelial cell that is part of some heart. + FBC:Autogenerated + @@ -13029,8 +18337,15 @@ + Any cell that is part of some His-Purkinje system. His-Purkinje system cell + + + + Any cell that is part of some His-Purkinje system. + FBC:Autogenerated + @@ -13056,9 +18371,15 @@ - + Any endothelial cell that is part of some heart. cardiac endothelial cell + + + + Any endothelial cell that is part of some heart. + FBC:Autogenerated + @@ -13085,8 +18406,15 @@ + Any photoreceptor cell that is part of some camera-type eye. camera-type eye photoreceptor cell + + + + Any photoreceptor cell that is part of some camera-type eye. + FBC:Autogenerated + @@ -13095,6 +18423,7 @@ A zygote in a plant or an animal. + MESH:D015053 zygote @@ -13122,8 +18451,15 @@ + Any glial cell that is part of some heart. cardiac glial cell + + + + Any glial cell that is part of some heart. + FBC:Autogenerated + @@ -13148,8 +18484,16 @@ + Any myoblast that develops into some cardiac muscle cell. + MESH:D032386 cardiac myoblast + + + + Any myoblast that develops into some cardiac muscle cell. + FBC:Autogenerated + @@ -13174,8 +18518,17 @@ + A neuron that has its soma in the heart. + This term is used in 3 GO terms that were created as part of the heart development focus project. cardiac neuron + + + + A neuron that has its soma in the heart. + PMID:12486170 + PMID:29265764 + @@ -13201,8 +18554,15 @@ + A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. spinal cord motor neuron + + + + A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. + GOC:nv + @@ -13227,8 +18587,16 @@ + A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites. paraxial cell + + + + A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites. + GOC:NV + PMID:11687492 + @@ -13237,8 +18605,16 @@ + A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. neural crest cell + + + + A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. + https://orcid.org/0000-0001-5208-3432 + https://orcid.org/0000-0002-9900-7880 + @@ -13346,8 +18722,16 @@ + A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses. progenitor cell + + + + A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses. + ISBN:978-1-62808-994-3 + https://doi.org/10.1016/B978-0-12-409503-8.00002-0 + @@ -13367,8 +18751,16 @@ + Any fibroblast that is part of skeletal muscle tissue. skeletal muscle fibroblast + + + + Any fibroblast that is part of skeletal muscle tissue. + PMID:28369879 + https://orcid.org/0000-0001-6164-0667 + @@ -13388,8 +18780,49 @@ + Any microvascular endothelial cell that is part of the dermis. dermal microvascular endothelial cell + + + + Any microvascular endothelial cell that is part of the dermis. + BTO:0004574 + CL:patterns/cellPartOfAnatomicalEntity + + + + + + + + + + + + + + + + + + + + + + + + + + Epithelial cell that is part of the colon epithelium. + colon epithelial cell + + + + + Epithelial cell that is part of the colon epithelium. + GOC:NV + @@ -13414,8 +18847,16 @@ + A cell that, by division or terminal differentiation, can give rise to other cell types. + Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. precursor cell + + + + A cell that, by division or terminal differentiation, can give rise to other cell types. + GOC:dos + @@ -13440,8 +18881,15 @@ + Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain. neutrophillic cytoplasm + + + + Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain. + GOC:add + @@ -13466,8 +18914,15 @@ + Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain. acidophilic cytoplasm + + + + Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain. + GOC:add + @@ -13492,8 +18947,15 @@ + Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions. basophilic cytoplasm + + + + Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions. + GOC:tfm + @@ -13518,8 +18980,15 @@ + Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions. polychromatophilic cytoplasm + + + + Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions. + GOC:tfm + @@ -13572,7 +19041,6 @@ Any chondrocyte that is part of the tracheobronchial tree. - tracheobronchial chondrocyte @@ -13599,9 +19067,15 @@ - + A smooth muscle cell that is part of any blood vessel. blood vessel smooth muscle cell + + + + A smooth muscle cell that is part of any blood vessel. + PMID:9108778 + @@ -13626,9 +19100,116 @@ - + A smooth muscle cell that is part of the tracheobronchial tree. tracheobronchial smooth muscle cell + + + + A smooth muscle cell that is part of the tracheobronchial tree. + PMID:10853867 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes. + extrahepatic cholangiocyte + + + + + An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes. + PMID:23720296 + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid. + EFO:0010705 + endothelial cell of periportal hepatic sinusoid + + + + + An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid. + PMID:27423426 + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid. + EFO:0010706 + endothelial cell of pericentral hepatic sinusoid + + + + + An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid. + PMID:27423426 + @@ -13649,8 +19230,15 @@ + Any neuroendocrine cell that is part of some stomach. stomach neuroendocrine cell + + + + Any neuroendocrine cell that is part of some stomach. + FBC:Autogenerated + @@ -13686,9 +19274,17 @@ - + A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. lung neuroendocrine cell + + + + A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. + PMID:33355253 + doi:10.3109/01902148209069653 + doi:10.7554/eLife.78216 + @@ -13713,9 +19309,15 @@ - + Any ciliated cell that is part of some lung. lung ciliated cell + + + + Any ciliated cell that is part of some lung. + FBC:Autogenerated + @@ -13740,8 +19342,15 @@ + Any secretory cell that is part of some lung. lung secretory cell + + + + Any secretory cell that is part of some lung. + FBC:Autogenerated + @@ -13754,6 +19363,210 @@ + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the small intestine. + FMA:15050 + smooth muscle cell of small intestine + + + + + A smooth muscle cell that is part of the small intestine. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the duodenum. + FMA:15058 + smooth muscle fiber of duodenum + + + + + A smooth muscle cell that is part of the duodenum. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the large intestine. + FMA:15653 + smooth muscle cell of large intestine + + + + + A smooth muscle cell that is part of the large intestine. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the colon. + FMA:15663 + smooth muscle cell of colon + + + + + A smooth muscle cell that is part of the colon. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the sigmoid colon. + FMA:17521 + smooth muscle cell of sigmoid colon + + + + + A smooth muscle cell that is part of the sigmoid colon. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the rectum. + FMA:17522 + smooth muscle cell of rectum + + + + + A smooth muscle cell that is part of the rectum. + GOC:tfm + + + + @@ -13775,8 +19588,16 @@ + A fibroblast that is part of the areolar connective tissue. + FMA:261279 fibroblast of areolar connective tissue + + + + A fibroblast that is part of the areolar connective tissue. + GOC:tfm + @@ -13802,8 +19623,16 @@ + A fibroblast that is part of the tunica adventitia of artery. + FMA:261285 fibroblast of tunica adventitia of artery + + + + A fibroblast that is part of the tunica adventitia of artery. + GOC:tfm + @@ -13834,8 +19663,16 @@ + A fibroblast that is part of the dense regular elastic tissue. + FMA:261287 fibroblast of dense regular elastic tissue + + + + A fibroblast that is part of the dense regular elastic tissue. + GOC:tfm + @@ -13850,9 +19687,16 @@ - + An adipocyte that is part of the epicardial fat. + FMA:261293 epicardial adipocyte + + + + An adipocyte that is part of the epicardial fat. + GOC:tfm + @@ -13877,8 +19721,16 @@ + An adipocyte that is part of the epicardial fat of right ventricle. + FMA:261297 adipocyte of epicardial fat of right ventricle + + + + An adipocyte that is part of the epicardial fat of right ventricle. + GOC:tfm + @@ -13903,8 +19755,16 @@ + An adipocyte that is part of the epicardial fat of left ventricle. + FMA:261300 adipocyte of epicardial fat of left ventricle + + + + An adipocyte that is part of the epicardial fat of left ventricle. + GOC:tfm + @@ -13929,9 +19789,16 @@ - + A serous secreting cell that is part of the epithelium of trachea. + FMA:263078 serous cell of epithelium of trachea + + + + A serous secreting cell that is part of the epithelium of trachea. + GOC:tfm + @@ -13956,9 +19823,16 @@ - + A serous secreting cell that is part of the epithelium of bronchus. + FMA:263080 serous cell of epithelium of bronchus + + + + A serous secreting cell that is part of the epithelium of bronchus. + GOC:tfm + @@ -13984,8 +19858,16 @@ + A serous secreting cell that is part of the epithelium of terminal bronchiole. + FMA:263082 serous cell of epithelium of terminal bronchiole + + + + A serous secreting cell that is part of the epithelium of terminal bronchiole. + GOC:tfm + @@ -14011,8 +19893,16 @@ + A transitional myocyte that is part of the interatrial septum. + FMA:263152 transitional myocyte of interatrial septum + + + + A transitional myocyte that is part of the interatrial septum. + GOC:tfm + @@ -14038,8 +19928,16 @@ + A transitional myocyte that is part of the interventricular septum. + FMA:263154 transitional myocyte of interventricular septum + + + + A transitional myocyte that is part of the interventricular septum. + GOC:tfm + @@ -14065,8 +19963,53 @@ + A Purkinje myocyte that is part of the interventricular septum. + FMA:263182 Purkinje myocyte of interventricular septum + + + + A Purkinje myocyte that is part of the interventricular septum. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates. + BTO:000125 + FMA:62911 + endothelial cell of hepatic sinusoid + + + + + An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates. + GOC:tfm + PMID:3926620 + @@ -14092,8 +20035,17 @@ + A muscle cell that is part of the sinoatrial node. + FMA:67102 myocyte of sinoatrial node + + + + A muscle cell that is part of the sinoatrial node. + FMA:67102 + GOC:tfm + @@ -14120,8 +20072,17 @@ + A muscle cell that is part of the atrioventricular node. + FMA:67106 myocyte of atrioventricular node + + + + A muscle cell that is part of the atrioventricular node. + FMA:67106 + GOC:tfm + @@ -14146,9 +20107,17 @@ - + An endothelial cell that is part of the arteriole. + FMA:67760 + KUPO:0001097 endothelial cell of arteriole + + + + An endothelial cell that is part of the arteriole. + GOC:tfm + @@ -14173,9 +20142,18 @@ - + A blood vessel endothelial cell that is part of an arterial endothelium. + BTO:0004758 + FMA:67761 + KUPO:0001095 endothelial cell of artery + + + + A blood vessel endothelial cell that is part of an arterial endothelium. + GOC:tfm + @@ -14200,9 +20178,50 @@ - + An endothelial cell that is part of the venule. + FMA:67762 endothelial cell of venule + + + + An endothelial cell that is part of the venule. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell that is part of the gallbladder. + FMA:67780 + epithelial cell of gallbladder + + + + + An epithelial cell that is part of the gallbladder. + GOC:tfm + @@ -14227,8 +20246,16 @@ + A somatic stem cell that is part of the epidermis. + FMA:70541 stem cell of epidermis + + + + A somatic stem cell that is part of the epidermis. + GOC:tfm + @@ -14253,8 +20280,16 @@ + A smooth muscle cell that is part of the ciliary body. + FMA:70610 ciliary muscle cell + + + + A smooth muscle cell that is part of the ciliary body. + GOC:tfm + @@ -14279,8 +20314,16 @@ + A mesothelial cell that is part of the anterior chamber of eyeball. + FMA:70615 mesothelial cell of anterior chamber of eye + + + + A mesothelial cell that is part of the anterior chamber of eyeball. + GOC:tfm + @@ -14305,8 +20348,16 @@ + A mesothelial cell that is part of the parietal peritoneum. + FMA:72142 mesothelial cell of parietal peritoneum + + + + A mesothelial cell that is part of the parietal peritoneum. + GOC:tfm + @@ -14331,9 +20382,16 @@ - + A mesothelial cell that is part of the visceral peritoneum. + FMA:72143 mesothelial cell of visceral peritoneum + + + + A mesothelial cell that is part of the visceral peritoneum. + GOC:tfm + @@ -14353,8 +20411,16 @@ + A transitional myocyte that is part of the sinoatrial node. + FMA:83384 transitional myocyte of sinoatrial node + + + + A transitional myocyte that is part of the sinoatrial node. + GOC:tfm + @@ -14374,8 +20440,16 @@ + A Purkinje myocyte that is part of the atrioventricular node. + FMA:83386 Purkinje myocyte of atrioventricular node + + + + A Purkinje myocyte that is part of the atrioventricular node. + GOC:tfm + @@ -14401,8 +20475,79 @@ + A myocardial endocrine cell that is part of the interventricular septum. + FMA:83390 myocardial endocrine cell of interventricular septum + + + + A myocardial endocrine cell that is part of the interventricular septum. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. + FMA:86481 + cholangiocyte + + + + + An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. + GOC:tfm + PMID:16550043 + PMID:18356246 + @@ -14427,8 +20572,16 @@ + A mesothelial cell that is part of the peritoneum. + FMA:86736 mesothelial cell of peritoneum + + + + A mesothelial cell that is part of the peritoneum. + GOC:tfm + @@ -14453,8 +20606,16 @@ + A mesothelial cell that is part of the pleura. + FMA:86737 mesothelial cell of pleura + + + + A mesothelial cell that is part of the pleura. + GOC:tfm + @@ -14479,8 +20640,16 @@ + A mesothelial cell that is part of the parietal pleura. + FMA:86738 mesothelial cell of parietal pleura + + + + A mesothelial cell that is part of the parietal pleura. + GOC:tfm + @@ -14505,9 +20674,78 @@ - + A mesothelial cell that is part of the visceral pleura. + FMA:86739 mesothelial cell of visceral pleura + + + + A mesothelial cell that is part of the visceral pleura. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the exocrine pancreas. + FMA:70986 + epithelial cell of exocrine pancreas + + + + + An epithelial cell of the exocrine pancreas. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract. + intestinal enteroendocrine cell + + + + + The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract. + MP:0010802 + @@ -14532,8 +20770,15 @@ + Any endothelial cell of vascular tree that is part of some lung. lung endothelial cell + + + + Any endothelial cell of vascular tree that is part of some lung. + FBC:Autogenerated + @@ -14558,9 +20803,51 @@ - + Any endothelial cell of vascular tree that is part of some pulmonary artery. + BTO:0001141 pulmonary artery endothelial cell + + + + Any endothelial cell of vascular tree that is part of some pulmonary artery. + FBC:Autogenerated + + + + + + + + + + + + + + + + + + + + + + + + + + A vascular endothelial cell found in colon blood vessels. + CALOHA:TS-2397 + colon endothelial cell + + + + + A vascular endothelial cell found in colon blood vessels. + NPX:PDR + https://orcid.org/0000-0001-5208-3432 + @@ -14586,8 +20873,223 @@ + Squamous cell of oral epithelium. + CALOHA:TS-1252 oral mucosa squamous cell + + + + Squamous cell of oral epithelium. + NPX:PDR + + + + + + + + + + + + + + + + + + + + + Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells. + CALOHA:TS-1274 + colon glandular cell + + + + + Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells. + NPX:PDR + + + + + + + + + + + + + + + + + + + + + + + + + + Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell. + CALOHA:TS-1275 + duodenum glandular cell + + + + + Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell. + NPX:PDR + + + + + + + + + + + + + + + + + + + + + + + + + + + Glandular cell of gallbladder epithelium. + CALOHA:TS-1278 + gallbladder glandular cell + + + + + Glandular cell of gallbladder epithelium. + NPX:PDR + + + + + + + + + + + + + + + + + + + + + + + + + + Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells. + CALOHA:TS-1281 + rectum glandular cell + + + + + Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells. + NPX:PDR + + + + + + + + + + + + + + + + + + + + + + + + + + + A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) . + CALOHA:TS-1286 + FMA:86928 + small intestine glandular cell + + + + + A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) . + NCI_Thesaurus:Small_Intestinal_Glandular_Cell + NPX:PDR + + + + + + + + + + + + + + + + + + + + + + + + + + + + Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts. + BTO:0000028 + CALOHA:TS-1242 + pancreas exocrine glandular cell + + + + + Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts. + HPA:HPA + NPX:PDR + @@ -14612,8 +21114,17 @@ + Circulating macrophages and tissue macrophages (alveolar macrophages) of lung. + CALOHA:TS-0576 lung macrophage + + + + Circulating macrophages and tissue macrophages (alveolar macrophages) of lung. + HPA:HPA + NPX:PDR + @@ -14638,8 +21149,16 @@ + Fibroblast from muscle organ. + CALOHA:TS-0643 muscle fibroblast + + + + Fibroblast from muscle organ. + NPX:PDR + @@ -14665,8 +21184,16 @@ + Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes. + CALOHA:TS-2109 bone marrow hematopoietic cell + + + + Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes. + NPX:PDR + @@ -14692,8 +21219,15 @@ + A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood. peripheral blood mononuclear cell + + + + A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood. + GOC:TermGenie + @@ -14718,8 +21252,15 @@ + Any blood vessel endothelial cell that is part of a microvascular endothelium. microvascular endothelial cell + + + + Any blood vessel endothelial cell that is part of a microvascular endothelium. + GOC:TermGenie + @@ -14744,8 +21285,15 @@ + Any blood vessel endothelial cell that is part of a dermis. dermis blood vessel endothelial cell + + + + Any blood vessel endothelial cell that is part of a dermis. + GOC:TermGenie + @@ -14770,8 +21318,15 @@ + Any skin fibroblast that is part of a skin of abdomen. fibroblast of skin of abdomen + + + + Any skin fibroblast that is part of a skin of abdomen. + GOC:TermGenie + @@ -14791,8 +21346,15 @@ + Any lung endothelial cell that is part of a microvascular endothelium. lung microvascular endothelial cell + + + + Any lung endothelial cell that is part of a microvascular endothelium. + GOC:TermGenie + @@ -14817,8 +21379,15 @@ + Any photoreceptor cell that is part of a compound eye. compound eye photoreceptor cell + + + + Any photoreceptor cell that is part of a compound eye. + GOC:TermGenie + @@ -14843,8 +21412,15 @@ + Any native cell that is part of a inner cell mass. inner cell mass cell + + + + Any native cell that is part of a inner cell mass. + GOC:TermGenie + @@ -14869,8 +21445,15 @@ + Any native cell that is part of a cardiac septum. cardiac septum cell + + + + Any native cell that is part of a cardiac septum. + GOC:TermGenie + @@ -14895,8 +21478,15 @@ + Any neuron that is part of a central nervous system. central nervous system neuron + + + + Any neuron that is part of a central nervous system. + GOC:TermGenie + @@ -14921,9 +21511,17 @@ - + A neuron that is part of a peripheral nervous system. + FMA:84664 peripheral nervous system neuron + + + + A neuron that is part of a peripheral nervous system. + GOC:TermGenie + ISBN:0721662544 + @@ -14948,8 +21546,15 @@ + Any fibroblast that is part of a embryo. embryonic fibroblast + + + + Any fibroblast that is part of a embryo. + GOC:TermGenie + @@ -14974,8 +21579,15 @@ + Any pericyte cell that is part of a brain. brain pericyte + + + + Any pericyte cell that is part of a brain. + GOC:TermGenie + @@ -15001,8 +21613,15 @@ + Any microvascular endothelial cell that is part of a brain. brain microvascular endothelial cell + + + + Any microvascular endothelial cell that is part of a brain. + GOC:TermGenie + @@ -15027,8 +21646,15 @@ + Any cardiac muscle cell that is part of a cardiac ventricle. ventricular cardiac muscle cell + + + + Any cardiac muscle cell that is part of a cardiac ventricle. + GOC:TermGenie + @@ -15054,8 +21680,116 @@ + Any motor neuron that is part of a brainstem. brainstem motor neuron + + + + Any motor neuron that is part of a brainstem. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + Any fibroblast that is part of a spleen. + splenic fibroblast + + + + + Any fibroblast that is part of a spleen. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + Any endothelial cell that is part of a spleen. + http://www.sciencellonline.com/site/productInformation.php?keyword=5500 + splenic endothelial cell + + + + + Any endothelial cell that is part of a spleen. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + Any dendritic cell that is part of a liver. + http://www.jleukbio.org/content/66/2/322.abstract + liver dendritic cell + + + + + Any dendritic cell that is part of a liver. + GOC:TermGenie + @@ -15080,8 +21814,16 @@ + Any fibroblast that is part of a female gonad. + http://www.sciencellonline.com/site/productInformation.php?keyword=7330 ovarian fibroblast + + + + Any fibroblast that is part of a female gonad. + GOC:TermGenie + @@ -15106,8 +21848,16 @@ + Any epithelial cell that is part of a female gonad. + http://www.sciencellonline.com/site/productInformation.php?keyword=7310 ovarian surface epithelial cell + + + + Any epithelial cell that is part of a female gonad. + GOC:TermGenie + @@ -15132,9 +21882,16 @@ - + Any fibroblast that is part of a cardiac ventricle. + http://www.sciencellonline.com/site/productInformation.php?keyword=6310 cardiac ventricle fibroblast + + + + Any fibroblast that is part of a cardiac ventricle. + GOC:TermGenie + @@ -15159,9 +21916,16 @@ - + Any fibroblast that is part of a cardiac atrium. + http://www.sciencellonline.com/site/productInformation.php?keyword=6320 cardiac atrium fibroblast + + + + Any fibroblast that is part of a cardiac atrium. + GOC:TermGenie + @@ -15186,8 +21950,50 @@ + Any fibroblast that is part of a pericardium. + http://www.sciencellonline.com/site/productInformation.php?keyword=6430 pericardium fibroblast + + + + Any fibroblast that is part of a pericardium. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + Any fibroblast that is part of a gallbladder. + http://www.sciencellonline.com/site/productInformation.php?keyword=5430 + gallbladder fibroblast + + + + + Any fibroblast that is part of a gallbladder. + GOC:TermGenie + @@ -15212,8 +22018,16 @@ + Any fibroblast that is part of a optic choroid. + http://www.sciencellonline.com/site/productInformation.php?keyword=6620 optic choroid fibroblast + + + + Any fibroblast that is part of a optic choroid. + GOC:TermGenie + @@ -15239,8 +22053,16 @@ + Any microvascular endothelial cell that is part of a adipose tissue. + http://www.sciencellonline.com/site/productInformation.php?keyword=7200 adipose microvascular endothelial cell + + + + Any microvascular endothelial cell that is part of a adipose tissue. + GOC:TermGenie + @@ -15265,8 +22087,49 @@ + Any migratory neural crest cell that is part of a cardiac neural crest. migratory cardiac neural crest cell + + + + Any migratory neural crest cell that is part of a cardiac neural crest. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + Any leukocyte that is part of a spleen. + Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. + splenocyte + + + + + Any leukocyte that is part of a spleen. + GOC:TermGenie + @@ -15291,8 +22154,15 @@ + Any mesenchymal stem cell of adipose tissue that is part of an abdomen. mesenchymal stem cell of abdominal adipose tissue + + + + Any mesenchymal stem cell of adipose tissue that is part of an abdomen. + GOC:TermGenie + @@ -15317,8 +22187,15 @@ + Any fibroblast of lung that is part of a bronchus. bronchus fibroblast of lung + + + + Any fibroblast of lung that is part of a bronchus. + GOC:TermGenie + @@ -15344,8 +22221,16 @@ + A ciliated epithelial cell of the esophagus. ciliated epithelial cell of esophagus + + + + A ciliated epithelial cell of the esophagus. + GOC:CellBLAST + PMID:29802404 + @@ -15365,8 +22250,16 @@ + Peripheral sensory neuron. peripheral sensory neuron + + + + Peripheral sensory neuron. + GOC:CellBLAST + PMID:30096314 + @@ -15391,9 +22284,15 @@ - + A cell that is part of the brain vasculature. brain vascular cell + + + + A cell that is part of the brain vasculature. + DOI:10.1101/2022.10.12.511898 + @@ -15419,9 +22318,15 @@ - + A GABAergic inhibitory neuron that is derived from the midbrain. midbrain-derived inhibitory neuron + + + + A GABAergic inhibitory neuron that is derived from the midbrain. + DOI:10.1101/2022.10.12.511898 + @@ -15446,8 +22351,15 @@ + A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli. somatosensory neuron + + + + A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli. + PMID:22865660 + @@ -15490,9 +22402,35 @@ - + + + + + + + A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets. + A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7. alveolar type 1 fibroblast cell + + + + A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets. + PMID:22268140 + PMID:26706109 + PMID:28886382 + PMID:29489752 + PMID:30675802 + PMID:33624948 + PMID:33707239 + PMID:9074756 + + + + + A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7. + https://doi.org/10.5281/zenodo.11165918 + @@ -15507,9 +22445,33 @@ - + + + + + + + A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia. + A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85. alveolar adventitial fibroblast + + + + A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia. + PMID:26706109 + PMID:28886382 + PMID:29752282 + PMID:30675802 + PMID:33208946 + PMID:33624948 + + + + + A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85. + https://doi.org/10.5281/zenodo.11165918 + @@ -15529,8 +22491,15 @@ + A lymphocyte located in blood. blood lymphocyte + + + + A lymphocyte located in blood. + + @@ -15555,8 +22524,15 @@ + Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. "Interstitial cell" is a morphological term and refers to a variety of cells with differing origins and phenotypes. interstitial cell + + + + Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. "Interstitial cell" is a morphological term and refers to a variety of cells with differing origins and phenotypes. + PMID:24987007 + @@ -15581,8 +22557,51 @@ + A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium. respiratory ciliated cell + + + + A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium. + PMID:18757316 + PMID:21364219 + + + + + + + + + + + + + + + + + + + + + + + + + + + A(n) serous secreting cell that is part of a(n) bronchus submucosal gland. + serous secreting cell of bronchus submucosal gland + + + + + A(n) serous secreting cell that is part of a(n) bronchus submucosal gland. + PMID:5487122 + PMID:9651178 + @@ -15607,9 +22626,15 @@ - + A(n) vein endothelial cell that is part of a(n) respiratory system. vein endothelial cell of respiratory system + + + + A(n) vein endothelial cell that is part of a(n) respiratory system. + PMID:34030460 + @@ -15634,9 +22659,16 @@ - + A smooth muscle cell that is part of a bronchiole. bronchiolar smooth muscle cell + + + + A smooth muscle cell that is part of a bronchiole. + ISBN:9781260462982 + PMID:15347627 + @@ -15662,9 +22694,123 @@ - + A megakaryocyte that is resident in the lung connective tissue. lung megakaryocyte + + + + A megakaryocyte that is resident in the lung connective tissue. + PMID:33351116 + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucus secreting cell that is part of a submucosal gland of the trachea. + mucus secreting cell of trachea gland + + + + + A mucus secreting cell that is part of a submucosal gland of the trachea. + PMID:18931053 + PMID:29656943 + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucus secreting cell of a submucosal gland of the bronchus. + mucus secreting cell of bronchus submucosal gland + + + + + A mucus secreting cell of a submucosal gland of the bronchus. + PMID:19965983 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucus secreting cell of a submucosal gland of the tracheobronchial tree. + mucus secreting cell of tracheobronchial tree submucosal gland + + + + + A mucus secreting cell of a submucosal gland of the tracheobronchial tree. + PMID:30864819 + @@ -15678,9 +22824,28 @@ - + + + + + + + An alveolar macrophage that expresses CCL3. + A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67. CCL3-positive alveolar macrophage + + + + An alveolar macrophage that expresses CCL3. + PMID:37291214 + + + + + A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67. + https://doi.org/10.5281/zenodo.11165918 + @@ -15688,9 +22853,28 @@ - + + + + + + + An alveolar macrophage that expresses metallothionein. + A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41. metallothionein-positive alveolar macrophage + + + + An alveolar macrophage that expresses metallothionein. + PMID:37291214 + + + + + A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41. + https://doi.org/10.5281/zenodo.11165918 + @@ -15715,8 +22899,49 @@ + A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics. perivascular cell + + + + A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics. + PMID:24928499 + PMID:27889329 + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell that is part of a central vein of liver. + endothelial cell of central vein of liver + + + + + An endothelial cell that is part of a central vein of liver. + PMID:28287163 + @@ -15729,11 +22954,11 @@ - + - + @@ -15753,11 +22978,11 @@ - + - + @@ -15777,11 +23002,11 @@ - + - + @@ -15801,11 +23026,11 @@ - + - + @@ -15825,11 +23050,11 @@ - + - + @@ -15849,19 +23074,19 @@ - + - + - + - + @@ -15876,8 +23101,15 @@ + Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity. fetal pre-type II pulmonary alveolar epithelial cell + + + + Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity. + PMID:1316350 + @@ -15902,8 +23134,15 @@ + Any mesenchymal stem cell of adipose tissue that is part of an orbital region. mesenchymal stem cell of orbital adipose tissue + + + + Any mesenchymal stem cell of adipose tissue that is part of an orbital region. + + @@ -15955,8 +23194,17 @@ + The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. vacuole inheritance + + + + The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. + GOC:mcc + PMID:10873824 + PMID:14616069 + @@ -15982,8 +23230,16 @@ + The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. mitotic sister chromatid segregation + + + + The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. + GOC:ai + GOC:jl + @@ -16008,8 +23264,15 @@ + The lipid bilayer surrounding any of the compartments of the Golgi apparatus. Golgi membrane + + + + The lipid bilayer surrounding any of the compartments of the Golgi apparatus. + GOC:mah + @@ -16035,8 +23298,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. microtubule cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. + GOC:mah + @@ -16061,8 +23331,16 @@ + A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. nuclear chromosome + + + + A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. + GOC:dph + GOC:mah + @@ -16087,8 +23365,48 @@ + The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. polysaccharide biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + polysaccharide catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + PMID:33139480 + @@ -16125,8 +23443,18 @@ + Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. + Wikipedia:Mitosis + Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. mitotic cell cycle + + + + Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. + GOC:mah + ISBN:0815316194 + @@ -16151,8 +23479,15 @@ + The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. nuclear division + + + + The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. + GOC:mah + @@ -16177,8 +23512,16 @@ + A ribosome contained within a subcellular membrane-bounded organelle. organellar ribosome + + + + A ribosome contained within a subcellular membrane-bounded organelle. + GOC:mah + GOC:mcc + @@ -16186,8 +23529,15 @@ + A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. lytic vacuole + + + + A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. + GOC:krc + @@ -16213,8 +23563,15 @@ + The joining of 2 or more lipid bilayer membranes that surround the nucleus. nuclear membrane fusion + + + + The joining of 2 or more lipid bilayer membranes that surround the nucleus. + GOC:elh + @@ -16246,8 +23603,16 @@ + The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. + Wikipedia:Karyogamy karyogamy + + + + The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. + GOC:elh + @@ -16267,8 +23632,16 @@ + The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. syncytium formation by plasma membrane fusion + + + + The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. + GOC:mtg_muscle + GOC:tb + @@ -16282,8 +23655,18 @@ + The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. + NIF_Subcellular:sao1615953555 + Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. chromatin + + + + The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. + GOC:elh + PMID:20404130 + @@ -16291,8 +23674,17 @@ + A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. + NIF_Subcellular:sao445485807 + Wikipedia:Euchromatin euchromatin + + + + A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. + PMID:32017156 + @@ -16300,8 +23692,17 @@ + A compact and highly condensed form of chromatin that is refractory to transcription. + NIF_Subcellular:sao581845896 + Wikipedia:Heterochromatin heterochromatin + + + + A compact and highly condensed form of chromatin that is refractory to transcription. + PMID:32017156 + @@ -16310,8 +23711,16 @@ + The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. sister chromatid segregation + + + + The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. + GOC:ai + GOC:elh + @@ -16336,8 +23745,18 @@ + The developmental process in which the size or shape of a cell is generated and organized. cell morphogenesis + + + + The developmental process in which the size or shape of a cell is generated and organized. + GOC:clt + GOC:dph + GOC:go_curators + GOC:tb + @@ -16362,8 +23781,17 @@ + The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). skeletal system development + + + + The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). + GOC:dph + GOC:jid + GOC:tb + @@ -16388,8 +23816,18 @@ + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + Wikipedia:Ossification + Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. ossification + + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:mtg_mpo + PMID:17572649 + @@ -16423,8 +23861,19 @@ + A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. + Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. action potential + + + + A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. + GOC:dph + GOC:go_curators + GOC:tb + ISBN:978-0-07-139011-8 + @@ -16455,8 +23904,16 @@ + Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. + Wikipedia:Angiogenesis angiogenesis + + + + Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. + ISBN:0878932453 + @@ -16464,8 +23921,18 @@ + Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. + Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. cilium or flagellum-dependent cell motility + + + + Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. + GOC:cilia + GOC:hjd + GOC:krc + @@ -16509,8 +23976,15 @@ + The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. oocyte growth + + + + The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. + https://www.ncbi.nlm.nih.gov/books/NBK279054/ + @@ -16554,8 +24028,17 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. + Wikipedia:Oocyte_maturation oocyte maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. + GOC:devbiol + https://www.ncbi.nlm.nih.gov/books/NBK279054/ + @@ -16581,8 +24064,15 @@ + Any process that modulates the frequency, rate, extent or direction of cell growth. regulation of cell growth + + + + Any process that modulates the frequency, rate, extent or direction of cell growth. + GOC:go_curators + @@ -16607,8 +24097,15 @@ + Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time. regulation of cell growth by extracellular stimulus + + + + Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time. + GOC:dph + @@ -16639,8 +24136,16 @@ + The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. blood vessel development + + + + The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. + GOC:hjd + UBERON:0001981 + @@ -16665,8 +24170,15 @@ + The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. branching involved in blood vessel morphogenesis + + + + The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. + GOC:dph + @@ -16697,8 +24209,16 @@ + The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. + Wikipedia:Vasculogenesis vasculogenesis + + + + The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. + PMID:8999798 + @@ -16718,8 +24238,15 @@ + A process that results in a parallel arrangement of microtubules. microtubule bundle formation + + + + A process that results in a parallel arrangement of microtubules. + GOC:dph + @@ -16750,8 +24277,56 @@ + The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. + Wikipedia:Eye_development eye development + + + + The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. + GOC:jid + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. + urogenital system development + + + + + The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. + GOC:go_curators + @@ -16759,8 +24334,16 @@ + A homeostatic process in which an organism modulates its internal body temperature. + Wikipedia:Thermoregulation temperature homeostasis + + + + A homeostatic process in which an organism modulates its internal body temperature. + GOC:jl + @@ -16769,8 +24352,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. + Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. response to hypoxia + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. + GOC:hjd + @@ -16778,8 +24369,16 @@ + Cell migration that is accomplished by extension and retraction of a pseudopodium. + Note that this term refers to a mode of migration rather than to any particular cell type. ameboidal-type cell migration + + + + Cell migration that is accomplished by extension and retraction of a pseudopodium. + GOC:dph + @@ -16810,8 +24409,16 @@ + The nucleus of the female germ cell, a reproductive cell in females. female germ cell nucleus + + + + The nucleus of the female germ cell, a reproductive cell in females. + CL:0000021 + GOC:hjd + @@ -16842,8 +24449,50 @@ + Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). formation of translation initiation ternary complex + + + + Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). + GOC:hjd + + + + + + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of glucose within a cell. + intracellular glucose homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of glucose within a cell. + GOC:dph + GOC:go_curators + GOC:tb + @@ -16852,8 +24501,15 @@ + The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. gastric acid secretion + + + + The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:hjd + @@ -16873,8 +24529,16 @@ + The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. embryonic development via the syncytial blastoderm + + + + The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. + GOC:go_curators + GOC:mtg_sensu + @@ -16894,8 +24558,16 @@ + The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. in utero embryonic development + + + + The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. + GOC:go_curators + GOC:mtg_sensu + @@ -16926,8 +24598,15 @@ + The formation of the ectoderm, mesoderm and endoderm during gastrulation. formation of primary germ layer + + + + The formation of the ectoderm, mesoderm and endoderm during gastrulation. + GOC:go_curators + @@ -16958,8 +24637,15 @@ + The formation of ectoderm during gastrulation. ectoderm formation + + + + The formation of ectoderm during gastrulation. + GOC:go_curators + @@ -16990,8 +24676,15 @@ + The formation of the endoderm during gastrulation. endoderm formation + + + + The formation of the endoderm during gastrulation. + GOC:go_curators + @@ -17022,8 +24715,15 @@ + The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. mesoderm formation + + + + The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:go_curators + @@ -17054,8 +24754,15 @@ + The initial developmental process that will lead to the formation of an eye. lens placode formation + + + + The initial developmental process that will lead to the formation of an eye. + GOC:dph + @@ -17098,8 +24805,16 @@ + The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. compound eye morphogenesis + + + + The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. + GOC:dph + GOC:mtg_sensu + @@ -17130,8 +24845,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. compound eye photoreceptor cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. + GOC:go_curators + @@ -17162,8 +24884,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. eye photoreceptor cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. + GOC:go_curators + @@ -17194,8 +24923,18 @@ + The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. neural crest cell migration + + + + The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. + GOC:ascb_2009 + GOC:dph + GOC:tb + ISBN:0878932437 + @@ -17234,8 +24973,16 @@ + The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. + Wikipedia:Somitogenesis somitogenesis + + + + The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. + ISBN:0721662544 + @@ -17244,8 +24991,15 @@ + The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. morphogenesis of a branching structure + + + + The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. + ISBN:0721662544 + @@ -17276,8 +25030,18 @@ + The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. + Wikipedia:Neural_development#Neuron_migration + Wikipedia:Neuron_migration neuron migration + + + + The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. + CL:0000540 + GOC:go_curators + @@ -17308,8 +25072,17 @@ + The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell. establishment of lymphocyte polarity + + + + The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell. + GOC:mgi_curators + PMID:11244041 + PMID:12615889 + @@ -17340,8 +25113,17 @@ + The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. establishment of T cell polarity + + + + The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. + GOC:mgi_curators + PMID:11244041 + PMID:12615889 + @@ -17366,8 +25148,16 @@ + The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. myeloid dendritic cell activation + + + + The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + GOC:mgi_curators + ISBN:0781735149 + @@ -17388,8 +25178,15 @@ + A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell. cell activation + + + + A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell. + GOC:mgi_curators + @@ -17427,8 +25224,17 @@ + The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. + Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. leukocyte homeostasis + + + + The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. + GOC:add + ISBN:0781735149 + @@ -17457,8 +25263,16 @@ + The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus. T cell homeostatic proliferation + + + + The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus. + GOC:mgi_curators + ISBN:0781735149 + @@ -17467,8 +25281,17 @@ + The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. cytokine production + + + + The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:add + ISBN:0781735149 + @@ -17546,8 +25369,16 @@ + Any process that modulates the frequency, rate, or extent of production of a cytokine. regulation of cytokine production + + + + Any process that modulates the frequency, rate, or extent of production of a cytokine. + GOC:add + ISBN:0781735149 + @@ -17574,8 +25405,16 @@ + Any process that stops, prevents, or reduces the rate of production of a cytokine. negative regulation of cytokine production + + + + Any process that stops, prevents, or reduces the rate of production of a cytokine. + GOC:add + ISBN:0781735149 + @@ -17602,8 +25441,16 @@ + Any process that activates or increases the frequency, rate or extent of production of a cytokine. positive regulation of cytokine production + + + + Any process that activates or increases the frequency, rate or extent of production of a cytokine. + GOC:add + ISBN:0781735149 + @@ -17623,8 +25470,17 @@ + The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. serotonin secretion + + + + The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. + GOC:ef + ISBN:0198506732 + ISBN:0781735149 + @@ -17667,8 +25523,18 @@ + The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. blastocyst development + + + + The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17699,8 +25565,18 @@ + The initial formation of a blastocyst from a solid ball of cells known as a morula. + See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. blastocyst formation + + + + The initial formation of a blastocyst from a solid ball of cells known as a morula. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17731,8 +25607,18 @@ + The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. inner cell mass cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17763,8 +25649,18 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. trophectodermal cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17796,8 +25692,18 @@ + The morphogenesis of trophectoderm cells. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. trophectodermal cellular morphogenesis + + + + The morphogenesis of trophectoderm cells. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17828,8 +25734,18 @@ + An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. blastocyst growth + + + + An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17860,8 +25776,19 @@ + The proliferation of cells in the inner cell mass. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. inner cell mass cell proliferation + + + + The proliferation of cells in the inner cell mass. + GOC:dph + GOC:isa_complete + ISBN:0124020607 + ISBN:0198542771 + @@ -17892,8 +25819,18 @@ + The proliferation of cells in the trophectoderm. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. trophectodermal cell proliferation + + + + The proliferation of cells in the trophectoderm. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17922,8 +25859,16 @@ + A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. epithelial to mesenchymal transition + + + + A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. + GOC:dph + PMID:14701881 + @@ -17937,8 +25882,16 @@ + The morphogenesis of an embryonic epithelium into a tube-shaped structure. embryonic epithelial tube formation + + + + The morphogenesis of an embryonic epithelium into a tube-shaped structure. + GOC:dph + ISBN:0824072820 + @@ -17969,8 +25922,16 @@ + The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. neural plate morphogenesis + + + + The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. + GOC:dph + ISBN:0878932437 + @@ -18001,8 +25962,18 @@ + The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. neural plate development + + + + The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. + GOC:dph + GOC:ef + ISBN:0878932437 + ISBN:0878932585 + @@ -18033,8 +26004,17 @@ + The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + Wikipedia:Neurulation neural tube formation + + + + The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + GOC:dph + ISBN:0878932437 + @@ -18067,8 +26047,16 @@ + The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. neural fold formation + + + + The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. + GOC:dph + ISBN:0878932437 + @@ -18093,8 +26081,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. + defined as response to Saccharomycotina (true yeasts). This excludes fission yeast. response to yeast + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. + PMID:14707091 + @@ -18125,8 +26121,15 @@ + The progression of an endothelial cell over time, from its formation to the mature structure. endothelial cell development + + + + The progression of an endothelial cell over time, from its formation to the mature structure. + GOC:dph + @@ -18157,8 +26160,57 @@ + The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. endothelial cell morphogenesis + + + + The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. + GOC:ascb_2009 + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. + liver development + + + + + The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. + GOC:add + ISBN:068340007X + @@ -18172,8 +26224,16 @@ + A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. tissue homeostasis + + + + A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. + GOC:add + GOC:isa_complete + @@ -18198,8 +26258,16 @@ + The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. endothelial cell proliferation + + + + The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. + GOC:add + ISBN:0781735149 + @@ -18224,8 +26292,15 @@ + Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. regulation of endothelial cell proliferation + + + + Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. + GOC:add + @@ -18251,8 +26326,15 @@ + Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. negative regulation of endothelial cell proliferation + + + + Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. + GOC:add + @@ -18278,8 +26360,15 @@ + Any process that activates or increases the rate or extent of endothelial cell proliferation. positive regulation of endothelial cell proliferation + + + + Any process that activates or increases the rate or extent of endothelial cell proliferation. + GOC:add + @@ -18310,8 +26399,16 @@ + The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. vasculature development + + + + The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. + GOC:dph + UBERON:0002409 + @@ -18342,8 +26439,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. blood vessel maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. + GOC:dph + @@ -18351,8 +26455,17 @@ + Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. + Wikipedia:Intramembranous_ossification + An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. intramembranous ossification + + + + Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. + ISBN:0878932437 + @@ -18383,8 +26496,18 @@ + The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. morphogenesis of an epithelium + + + + The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. + GOC:dph + GOC:jl + GOC:tb + ISBN:0198506732 + @@ -18409,8 +26532,15 @@ + The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. morphogenesis of an epithelial sheet + + + + The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. + GOC:jl + @@ -18418,8 +26548,17 @@ + Any process that modulates the frequency or rate of heart contraction. regulation of heart rate + + + + Any process that modulates the frequency or rate of heart contraction. + GOC:dph + GOC:tb + PMID:10358008 + @@ -18446,8 +26585,15 @@ + Any process that activates or increases the rate of neuroblast proliferation. positive regulation of neuroblast proliferation + + + + Any process that activates or increases the rate of neuroblast proliferation. + GOC:dph + @@ -18473,8 +26619,15 @@ + The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. positive regulation of mesenchymal cell proliferation + + + + The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. + GOC:dph + @@ -18505,8 +26658,15 @@ + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. chondrocyte differentiation + + + + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. + GOC:dph + @@ -18537,8 +26697,15 @@ + The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. chondrocyte development + + + + The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + GOC:dph + @@ -18569,8 +26736,15 @@ + The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. epithelial cell development + + + + The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. + GOC:dph + @@ -18595,8 +26769,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. columnar/cuboidal epithelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. + GOC:dph + @@ -18627,8 +26808,15 @@ + The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. columnar/cuboidal epithelial cell development + + + + The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. + GOC:dph + @@ -18653,8 +26841,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. glandular epithelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. + GOC:dph + @@ -18685,8 +26880,15 @@ + The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. glandular epithelial cell development + + + + The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. + GOC:dph + @@ -18717,8 +26919,15 @@ + The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. columnar/cuboidal epithelial cell maturation + + + + The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. + GOC:dph + @@ -18749,8 +26958,15 @@ + The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. epithelial cell maturation + + + + The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. + GOC:dph + @@ -18781,8 +26997,15 @@ + The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. glandular epithelial cell maturation + + + + The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. + GOC:dph + @@ -18813,8 +27036,19 @@ + The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. optic cup morphogenesis involved in camera-type eye development + + + + The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. + GOC:dph + GOC:mtg_sensu + GOC:sdb_2009 + GOC:tb + ISBN:0878932437 + @@ -18842,8 +27076,16 @@ + Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells. inhibition of neuroepithelial cell differentiation + + + + Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells. + GOC:dph + PMID:16678814 + @@ -18863,8 +27105,17 @@ + A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. regulation of respiratory gaseous exchange by nervous system process + + + + A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. + GOC:dph + GOC:tb + PMID:12458206 + @@ -18895,8 +27146,16 @@ + The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. lens development in camera-type eye + + + + The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. + GOC:dph + ISBN:0582064333 + @@ -18933,8 +27192,16 @@ + The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. lens morphogenesis in camera-type eye + + + + The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. + GOC:dph + GOC:mtg_sensu + @@ -18959,8 +27226,16 @@ + The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. osteoclast proliferation + + + + The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. + CL:0000092 + GOC:hjd + @@ -18985,8 +27260,15 @@ + A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism. defense response to insect + + + + A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism. + GOC:add + @@ -19006,8 +27288,16 @@ + The movement of an immune cell in response to an external stimulus contributing to an inflammatory response. leukocyte chemotaxis involved in inflammatory response + + + + The movement of an immune cell in response to an external stimulus contributing to an inflammatory response. + GOC:add + ISBN:0781735149 + @@ -19027,8 +27317,16 @@ + The movement of an immune cell in response to an external stimulus a part of an immune response. leukocyte chemotaxis involved in immune response + + + + The movement of an immune cell in response to an external stimulus a part of an immune response. + GOC:add + ISBN:0781735149 + @@ -19059,8 +27357,18 @@ + The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. hematopoietic progenitor cell differentiation + + + + The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. + GOC:add + GOC:rl + ISBN:0781735149 + PMID:16551251 + @@ -19080,8 +27388,35 @@ + An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). + Wikipedia:Adaptive_immune_system adaptive immune response + + + + An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). + GOC:add + GO_REF:0000022 + ISBN:0781735149 + + + + + + + + + An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. + organ or tissue specific immune response + + + + + An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. + GOC:jal + GO_REF:0000022 + @@ -19089,8 +27424,17 @@ + Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. immune effector process + + + + Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19115,8 +27459,19 @@ + The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. lymphocyte homeostasis + + + + The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. + GOC:add + PMID:15826826 + PMID:16319493 + PMID:16551252 + PMID:16551262 + @@ -19142,8 +27497,16 @@ + The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. myeloid cell homeostasis + + + + The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. + CL:0000763 + GOC:add + @@ -19169,8 +27532,17 @@ + A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. cell activation involved in immune response + + + + A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19190,8 +27562,16 @@ + A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. endothelial cell activation involved in immune response + + + + A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19216,8 +27596,16 @@ + A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response. leukocyte activation involved in inflammatory response + + + + A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response. + GOC:add + ISBN:0781735149 + @@ -19242,8 +27630,16 @@ + A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. myeloid leukocyte activation + + + + A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. + GOC:add + ISBN:0781735149 + @@ -19252,8 +27648,16 @@ + A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. myeloid cell activation involved in immune response + + + + A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19273,8 +27677,16 @@ + The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. myeloid dendritic cell activation involved in immune response + + + + The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19294,8 +27706,17 @@ + The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. monocyte activation involved in immune response + + + + The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + PMID:16551245 + @@ -19321,8 +27742,16 @@ + A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. macrophage activation involved in immune response + + + + A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19342,8 +27771,16 @@ + The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response. myeloid dendritic cell differentiation involved in immune response + + + + The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response. + GOC:add + ISBN:0781735149 + @@ -19363,8 +27800,16 @@ + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. lymphocyte activation involved in immune response + + + + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19384,8 +27829,16 @@ + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. T cell activation involved in immune response + + + + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19405,8 +27858,17 @@ + The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. T cell differentiation involved in immune response + + + + The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. + GOC:add + ISBN:0781735149 + @@ -19426,8 +27888,16 @@ + The expansion of a T cell population by cell division as part of an immune response. T cell proliferation involved in immune response + + + + The expansion of a T cell population by cell division as part of an immune response. + GOC:add + ISBN:0781735149 + @@ -19452,8 +27922,16 @@ + The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. myeloid progenitor cell differentiation + + + + The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. + GOC:add + PMID:16551264 + @@ -19478,8 +27956,17 @@ + The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. lymphoid progenitor cell differentiation + + + + The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. + GOC:add + PMID:16551251 + PMID:16551264 + @@ -19487,8 +27974,17 @@ + The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. serotonin production involved in inflammatory response + + + + The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. + GOC:add + ISBN:0781735149 + PMID:16730260 + @@ -19508,8 +28004,16 @@ + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. leukocyte activation involved in immune response + + + + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19535,8 +28039,18 @@ + The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. cytokine production involved in immune response + + + + The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19556,8 +28070,17 @@ + Any process that contributes to cytokine production by a T cell. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. T cell cytokine production + + + + Any process that contributes to cytokine production by a T cell. + GOC:add + ISBN:0781735149 + @@ -19583,8 +28106,17 @@ + Any process that contributes to cytokine production by a dendritic cell. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. dendritic cell cytokine production + + + + Any process that contributes to cytokine production by a dendritic cell. + GOC:add + ISBN:0781735149 + @@ -19611,8 +28143,17 @@ + Any process that contributes to cytokine production by a myeloid dendritic cell. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. myeloid dendritic cell cytokine production + + + + Any process that contributes to cytokine production by a myeloid dendritic cell. + GOC:add + ISBN:0781735149 + @@ -19646,8 +28187,65 @@ + Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. + Wikipedia:Immune_system + Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). immune system process + + + + Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. + GOC:add + GO_REF:0000022 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An immune response taking place in the liver. + hepatic immune response + + + + + An immune response taking place in the liver. + GOC:jal + GO_REF:0000022 + ISBN:0781735149 + @@ -19672,8 +28270,18 @@ + The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex. MHC protein complex assembly + + + + The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex. + GOC:add + ISBN:0781735149 + PMID:15771591 + PMID:15928678 + @@ -19698,8 +28306,17 @@ + The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex. MHC class II protein complex assembly + + + + The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex. + GOC:add + ISBN:0781735149 + PMID:15771591 + @@ -19719,8 +28336,19 @@ + The movement of a dendritic cell in response to an external stimulus. dendritic cell chemotaxis + + + + The movement of a dendritic cell in response to an external stimulus. + CL:0000451 + GOC:add + ISBN:0781735149 + PMID:15814331 + PMID:16056255 + @@ -19746,8 +28374,18 @@ + The movement of a myeloid dendritic cell in response to an external stimulus. myeloid dendritic cell chemotaxis + + + + The movement of a myeloid dendritic cell in response to an external stimulus. + GOC:add + ISBN:0781735149 + PMID:15814331 + PMID:16056255 + @@ -19756,8 +28394,18 @@ + The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. production of molecular mediator of immune response + + + + The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19782,8 +28430,16 @@ + The regulated release of serotonin by a cell as part of an inflammatory response. serotonin secretion involved in inflammatory response + + + + The regulated release of serotonin by a cell as part of an inflammatory response. + GOC:add + ISBN:0781735149 + @@ -19820,8 +28476,17 @@ + Any process involved in the carrying out of an immune response by a leukocyte. leukocyte mediated immunity + + + + Any process involved in the carrying out of an immune response by a leukocyte. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19846,8 +28511,17 @@ + Any process involved in the carrying out of an immune response by a myeloid leukocyte. myeloid leukocyte mediated immunity + + + + Any process involved in the carrying out of an immune response by a myeloid leukocyte. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19872,8 +28546,17 @@ + Any process involved in the carrying out of an immune response by a lymphocyte. lymphocyte mediated immunity + + + + Any process involved in the carrying out of an immune response by a lymphocyte. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19899,8 +28582,17 @@ + Any process involved in the carrying out of an immune response by a T cell. T cell mediated immunity + + + + Any process involved in the carrying out of an immune response by a T cell. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19931,8 +28623,17 @@ + The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. T cell antigen processing and presentation + + + + The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + PMID:11417857 + PMID:15120183 + @@ -19940,8 +28641,18 @@ + An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + + + + An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. + GOC:add + GOC:mtg_sensu + ISBN:0781735149 + ISBN:1405196831 + @@ -19966,8 +28677,17 @@ + The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. dendritic cell antigen processing and presentation + + + + The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + ISBN:0781735149 + PMID:15771591 + @@ -19992,8 +28712,17 @@ + The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. myeloid dendritic cell antigen processing and presentation + + + + The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + ISBN:0781735149 + PMID:15771591 + @@ -20018,8 +28747,16 @@ + The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. monocyte antigen processing and presentation + + + + The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + PMID:11200054 + @@ -20044,8 +28781,17 @@ + The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. macrophage antigen processing and presentation + + + + The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + ISBN:0781735149 + PMID:15771591 + @@ -20053,8 +28799,19 @@ + The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + + + + The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. + GOC:add + ISBN:0781735149 + PMID:15531770 + PMID:15771591 + PMID:16153240 + @@ -20080,8 +28837,16 @@ + The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. immune system development + + + + The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. + GOC:add + GOC:dph + @@ -20112,8 +28877,17 @@ + The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. leukocyte differentiation + + + + The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + CL:0000738 + GOC:add + PMID:16551264 + @@ -20139,8 +28913,20 @@ + The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response. leukocyte migration involved in immune response + + + + The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response. + GOC:add + ISBN:0781735149 + PMID:14680625 + PMID:14708592 + PMID:7507411 + PMID:8600538 + @@ -20165,8 +28951,20 @@ + The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. leukocyte migration involved in inflammatory response + + + + The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. + GOC:add + ISBN:0781735149 + PMID:14680625 + PMID:14708592 + PMID:7507411 + PMID:8600538 + @@ -20180,8 +28978,18 @@ + The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. production of molecular mediator involved in inflammatory response + + + + The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:add + GOC:dph + GOC:tb + ISBN:0781735149 + @@ -20201,8 +29009,16 @@ + The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. cytokine production involved in inflammatory response + + + + The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. + GOC:add + ISBN:0781735149 + @@ -20229,8 +29045,17 @@ + The movement of a monocyte in response to an external stimulus. monocyte chemotaxis + + + + The movement of a monocyte in response to an external stimulus. + GOC:add + PMID:11696603 + PMID:15173832 + @@ -20261,8 +29086,16 @@ + The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed. pro-T cell differentiation + + + + The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed. + GOC:add + ISBN:0781735149 + @@ -20288,8 +29121,16 @@ + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. myeloid leukocyte differentiation + + + + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. + GOC:add + PMID:16551251 + @@ -20314,8 +29155,15 @@ + Any process that modulates the frequency, rate, or extent of antigen processing and presentation. regulation of antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of antigen processing and presentation. + GOC:add + @@ -20341,8 +29189,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation. negative regulation of antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation. + GOC:add + @@ -20368,8 +29223,15 @@ + Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. positive regulation of antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. + GOC:add + @@ -20394,8 +29256,15 @@ + Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + + + + Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. + GOC:add + @@ -20421,8 +29290,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. + GOC:add + @@ -20448,8 +29324,15 @@ + Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + + + + Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. + GOC:add + @@ -20474,8 +29357,15 @@ + Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation. regulation of dendritic cell antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation. + GOC:add + @@ -20501,8 +29391,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation. negative regulation of dendritic cell antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation. + GOC:add + @@ -20528,8 +29425,15 @@ + Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation. positive regulation of dendritic cell antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation. + GOC:add + @@ -20554,8 +29458,15 @@ + Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. regulation of myeloid dendritic cell antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. + GOC:add + @@ -20581,8 +29492,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. negative regulation of myeloid dendritic cell antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. + GOC:add + @@ -20608,8 +29526,15 @@ + Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. positive regulation of myeloid dendritic cell antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. + GOC:add + @@ -20634,8 +29559,15 @@ + Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation. regulation of monocyte antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation. + GOC:add + @@ -20661,8 +29593,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation. negative regulation of monocyte antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation. + GOC:add + @@ -20688,8 +29627,15 @@ + Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation. positive regulation of monocyte antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation. + GOC:add + @@ -20714,8 +29660,15 @@ + Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation. regulation of macrophage antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation. + GOC:add + @@ -20741,8 +29694,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation. negative regulation of macrophage antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation. + GOC:add + @@ -20768,8 +29728,15 @@ + Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation. positive regulation of macrophage antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation. + GOC:add + @@ -20795,8 +29762,15 @@ + Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation. regulation of T cell antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation. + GOC:add + @@ -20823,8 +29797,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation. negative regulation of T cell antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation. + GOC:add + @@ -20851,8 +29832,15 @@ + Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation. positive regulation of T cell antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation. + GOC:add + @@ -20877,8 +29865,15 @@ + Any process that modulates the frequency, rate, or extent of an immune system process. regulation of immune system process + + + + Any process that modulates the frequency, rate, or extent of an immune system process. + GOC:add + @@ -20904,8 +29899,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. negative regulation of immune system process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. + GOC:add + @@ -20931,8 +29933,15 @@ + Any process that activates or increases the frequency, rate, or extent of an immune system process. positive regulation of immune system process + + + + Any process that activates or increases the frequency, rate, or extent of an immune system process. + GOC:add + @@ -20958,8 +29967,15 @@ + Any process that modulates the frequency, rate, or extent of leukocyte migration. regulation of leukocyte migration + + + + Any process that modulates the frequency, rate, or extent of leukocyte migration. + GOC:add + @@ -20986,8 +30002,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. negative regulation of leukocyte migration + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. + GOC:add + @@ -21014,8 +30037,15 @@ + Any process that activates or increases the frequency, rate, or extent of leukocyte migration. positive regulation of leukocyte migration + + + + Any process that activates or increases the frequency, rate, or extent of leukocyte migration. + GOC:add + @@ -21041,8 +30071,15 @@ + Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. regulation of leukocyte chemotaxis + + + + Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. + GOC:add + @@ -21069,8 +30106,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. negative regulation of leukocyte chemotaxis + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. + GOC:add + @@ -21097,8 +30141,15 @@ + Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. positive regulation of leukocyte chemotaxis + + + + Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. + GOC:add + @@ -21124,8 +30175,15 @@ + Any process that modulates the frequency, rate, or extent of leukocyte activation. regulation of leukocyte activation + + + + Any process that modulates the frequency, rate, or extent of leukocyte activation. + GOC:add + @@ -21152,8 +30210,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation. negative regulation of leukocyte activation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation. + GOC:add + @@ -21180,8 +30245,15 @@ + Any process that activates or increases the frequency, rate, or extent of leukocyte activation. positive regulation of leukocyte activation + + + + Any process that activates or increases the frequency, rate, or extent of leukocyte activation. + GOC:add + @@ -21206,8 +30278,15 @@ + Any process that modulates the frequency, rate, or extent of an immune effector process. regulation of immune effector process + + + + Any process that modulates the frequency, rate, or extent of an immune effector process. + GOC:add + @@ -21233,8 +30312,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. negative regulation of immune effector process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. + GOC:add + @@ -21260,8 +30346,15 @@ + Any process that activates or increases the frequency, rate, or extent of an immune effector process. positive regulation of immune effector process + + + + Any process that activates or increases the frequency, rate, or extent of an immune effector process. + GOC:add + @@ -21287,8 +30380,15 @@ + Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. regulation of production of molecular mediator of immune response + + + + Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. + GOC:add + @@ -21315,8 +30415,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. negative regulation of production of molecular mediator of immune response + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. + GOC:add + @@ -21343,8 +30450,15 @@ + Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. positive regulation of production of molecular mediator of immune response + + + + Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. + GOC:add + @@ -21369,8 +30483,15 @@ + Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. regulation of leukocyte mediated immunity + + + + Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. + GOC:add + @@ -21396,8 +30517,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. negative regulation of leukocyte mediated immunity + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. + GOC:add + @@ -21423,8 +30551,15 @@ + Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. positive regulation of leukocyte mediated immunity + + + + Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. + GOC:add + @@ -21449,8 +30584,15 @@ + Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. regulation of lymphocyte mediated immunity + + + + Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. + GOC:add + @@ -21476,8 +30618,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. negative regulation of lymphocyte mediated immunity + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. + GOC:add + @@ -21503,8 +30652,15 @@ + Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. positive regulation of lymphocyte mediated immunity + + + + Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. + GOC:add + @@ -21530,8 +30686,15 @@ + Any process that modulates the frequency, rate, or extent of T cell mediated immunity. regulation of T cell mediated immunity + + + + Any process that modulates the frequency, rate, or extent of T cell mediated immunity. + GOC:add + @@ -21558,8 +30721,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. negative regulation of T cell mediated immunity + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. + GOC:add + @@ -21586,8 +30756,15 @@ + Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. positive regulation of T cell mediated immunity + + + + Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. + GOC:add + @@ -21613,8 +30790,15 @@ + Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. regulation of cytokine production involved in immune response + + + + Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. + GOC:add + @@ -21641,8 +30825,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. negative regulation of cytokine production involved in immune response + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. + GOC:add + @@ -21669,8 +30860,15 @@ + Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. positive regulation of cytokine production involved in immune response + + + + Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. + GOC:add + @@ -21696,8 +30894,15 @@ + Any process that modulates the frequency, rate, or extent of T cell cytokine production. regulation of T cell cytokine production + + + + Any process that modulates the frequency, rate, or extent of T cell cytokine production. + GOC:add + @@ -21724,8 +30929,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production. negative regulation of T cell cytokine production + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production. + GOC:add + @@ -21752,8 +30964,15 @@ + Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. positive regulation of T cell cytokine production + + + + Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. + GOC:add + @@ -21779,8 +30998,15 @@ + Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production. regulation of dendritic cell cytokine production + + + + Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production. + GOC:add + @@ -21807,8 +31033,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production. negative regulation of dendritic cell cytokine production + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production. + GOC:add + @@ -21835,8 +31068,15 @@ + Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production. positive regulation of dendritic cell cytokine production + + + + Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production. + GOC:add + @@ -21862,8 +31102,15 @@ + Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production. regulation of myeloid dendritic cell cytokine production + + + + Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production. + GOC:add + @@ -21890,8 +31137,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production. negative regulation of myeloid dendritic cell cytokine production + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production. + GOC:add + @@ -21919,8 +31173,15 @@ + Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production. positive regulation of myeloid dendritic cell cytokine production + + + + Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production. + GOC:add + @@ -21946,8 +31207,15 @@ + Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. regulation of myeloid leukocyte differentiation + + + + Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. + GOC:add + @@ -21974,8 +31242,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. negative regulation of myeloid leukocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. + GOC:add + @@ -22002,8 +31277,15 @@ + Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. positive regulation of myeloid leukocyte differentiation + + + + Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. + GOC:add + @@ -22023,8 +31305,15 @@ + The controlled release of a peptide from a cell or a tissue. peptide secretion + + + + The controlled release of a peptide from a cell or a tissue. + GOC:add + @@ -22050,8 +31339,15 @@ + Any process that modulates the frequency, rate, or extent of peptide secretion. regulation of peptide secretion + + + + Any process that modulates the frequency, rate, or extent of peptide secretion. + GOC:add + @@ -22077,8 +31373,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. negative regulation of peptide secretion + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. + GOC:add + @@ -22104,8 +31407,15 @@ + Any process that activates or increases the frequency, rate, or extent of peptide secretion. positive regulation of peptide secretion + + + + Any process that activates or increases the frequency, rate, or extent of peptide secretion. + GOC:add + @@ -22130,8 +31440,15 @@ + Any process that modulates the frequency, rate, or extent of an adaptive immune response. regulation of adaptive immune response + + + + Any process that modulates the frequency, rate, or extent of an adaptive immune response. + GOC:add + @@ -22157,8 +31474,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. negative regulation of adaptive immune response + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. + GOC:add + @@ -22184,8 +31508,15 @@ + Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. positive regulation of adaptive immune response + + + + Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. + GOC:add + @@ -22222,8 +31553,16 @@ + Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + + + + Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. + GOC:add + GOC:mtg_sensu + @@ -22249,8 +31588,16 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. + GOC:add + GOC:mtg_sensu + @@ -22276,8 +31623,16 @@ + Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + + + + Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. + GOC:add + GOC:mtg_sensu + @@ -22302,8 +31657,16 @@ + Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of response to biotic stimulus + + + + Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. + GOC:add + @@ -22329,8 +31692,16 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of response to biotic stimulus + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. + GOC:add + @@ -22356,8 +31727,16 @@ + Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of response to biotic stimulus + + + + Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. + GOC:add + @@ -22382,8 +31761,15 @@ + Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. regulation of myeloid leukocyte mediated immunity + + + + Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. + GOC:add + @@ -22409,8 +31795,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity. negative regulation of myeloid leukocyte mediated immunity + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity. + GOC:add + @@ -22436,8 +31829,15 @@ + Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. positive regulation of myeloid leukocyte mediated immunity + + + + Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. + GOC:add + @@ -22468,8 +31868,15 @@ + The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move. tendon sheath development + + + + The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move. + PMID:20696843 + @@ -22477,8 +31884,16 @@ + The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. regionalization + + + + The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. + GOC:dph + GOC:isa_complete + @@ -22495,8 +31910,16 @@ + A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. developmental process involved in reproduction + + + + A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. + GOC:dph + GOC:isa_complete + @@ -22527,8 +31950,16 @@ + The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. heart morphogenesis + + + + The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + GOC:dph + GOC:isa_complete + @@ -22536,8 +31967,15 @@ + A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. system process + + + + A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. + GOC:mtg_cardio + @@ -22568,8 +32006,16 @@ + A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. skeletal muscle contraction + + + + A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. + GOC:mtg_cardio + GOC:mtg_muscle + @@ -22577,8 +32023,15 @@ + A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. muscle system process + + + + A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. + GOC:mtg_cardio + @@ -22586,8 +32039,34 @@ + A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. + Wikipedia:Circulatory_system circulatory system process + + + + A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. + GOC:mtg_cardio + + + + + + + + + A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). + renal system process + + + + + A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). + GOC:cjm + GOC:mtg_cardio + GOC:mtg_kidney_jan10 + @@ -22595,8 +32074,15 @@ + A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. heart process + + + + A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + GOC:mtg_cardio + @@ -22610,8 +32096,17 @@ + A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. respiratory system process + + + + A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. + GOC:dph + GOC:mtg_cardio + GOC:tb + @@ -22620,8 +32115,15 @@ + The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. detection of oxygen + + + + The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. + GOC:mtg_cardio + @@ -22656,8 +32158,15 @@ + Any process that mediates the transfer of information from mesodermal cells to endodermal cells. mesodermal-endodermal cell signaling + + + + Any process that mediates the transfer of information from mesodermal cells to endodermal cells. + GOC:mtg_heart + @@ -22692,8 +32201,15 @@ + Any process that mediates the transfer of information from endodermal cells to mesodermal cells. endodermal-mesodermal cell signaling + + + + Any process that mediates the transfer of information from endodermal cells to mesodermal cells. + GOC:mtg_heart + @@ -22724,8 +32240,15 @@ + The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field. cardiogenic plate morphogenesis + + + + The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field. + GOC:mtg_heart + @@ -22769,8 +32292,15 @@ + The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. embryonic heart tube morphogenesis + + + + The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. + GOC:mtg_heart + @@ -22801,8 +32331,15 @@ + The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. embryonic heart tube formation + + + + The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. + GOC:mtg_heart + @@ -22810,8 +32347,15 @@ + The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis. embryonic heart tube formation via epithelial folding + + + + The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis. + GOC:mtg_heart + @@ -22837,8 +32381,15 @@ + The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation. neural crest cell migration involved in heart formation + + + + The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation. + GOC:mtg_heart + @@ -22869,8 +32420,15 @@ + The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. outflow tract septum morphogenesis + + + + The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. + GOC:mtg_heart + @@ -22901,8 +32459,15 @@ + The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. membranous septum morphogenesis + + + + The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. + GOC:mtg_heart + @@ -22933,8 +32498,15 @@ + The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. muscular septum morphogenesis + + + + The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. + GOC:mtg_heart + @@ -22965,8 +32537,16 @@ + The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. outflow tract morphogenesis + + + + The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. + GOC:mtg_heart + UBERON:0004145 + @@ -22992,8 +32572,15 @@ + The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation. morphogenesis of an epithelial fold involved in embryonic heart tube formation + + + + The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation. + GOC:mtg_heart + @@ -23018,8 +32605,17 @@ + Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. regulation of animal organ formation + + + + Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. + GOC:dph + GOC:mtg_heart + GOC:tb + @@ -23050,8 +32646,15 @@ + The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. endocardium development + + + + The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:mtg_heart + @@ -23076,8 +32679,15 @@ + The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. endothelium development + + + + The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. + GOC:mtg_heart + @@ -23108,8 +32718,15 @@ + The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. morphogenesis of an endothelium + + + + The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. + GOC:mtg_heart + @@ -23140,8 +32757,15 @@ + The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. endocardium morphogenesis + + + + The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:mtg_heart + @@ -23166,8 +32790,15 @@ + The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. cardiac conduction system development + + + + The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. + GOC:mtg_heart + @@ -23198,8 +32829,15 @@ + The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system. atrioventricular node development + + + + The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system. + GOC:mtg_heart + @@ -23230,8 +32868,15 @@ + The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. sinoatrial node development + + + + The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. + GOC:mtg_heart + @@ -23262,8 +32907,15 @@ + The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. His-Purkinje system development + + + + The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. + GOC:mtg_heart + @@ -23294,8 +32946,16 @@ + The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. Purkinje myocyte development + + + + The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_heart + @@ -23326,8 +32986,16 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle. Purkinje myocyte differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle. + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_heart + @@ -23353,8 +33021,15 @@ + The process in which the anatomical structures of veins of the heart are generated and organized. coronary vein morphogenesis + + + + The process in which the anatomical structures of veins of the heart are generated and organized. + GOC:mtg_heart + @@ -23385,8 +33060,15 @@ + The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. endocardial cushion development + + + + The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. + GOC:mtg_heart + @@ -23423,8 +33105,15 @@ + The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. endocardial cushion morphogenesis + + + + The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. + GOC:mtg_heart + @@ -23455,8 +33144,15 @@ + The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart. cardiac skeleton development + + + + The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart. + GOC:mtg_heart + @@ -23487,8 +33183,15 @@ + The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. cardiac chamber development + + + + The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. + GOC:mtg_heart + @@ -23525,8 +33228,15 @@ + The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. cardiac chamber morphogenesis + + + + The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. + GOC:mtg_heart + @@ -23557,8 +33267,15 @@ + The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. cardiac chamber formation + + + + The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. + GOC:mtg_heart + @@ -23589,8 +33306,15 @@ + The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. cardiac ventricle morphogenesis + + + + The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. + GOC:mtg_heart + @@ -23621,8 +33345,15 @@ + The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. cardiac atrium morphogenesis + + + + The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. + GOC:mtg_heart + @@ -23653,8 +33384,15 @@ + The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. cardiac atrium formation + + + + The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. + GOC:mtg_heart + @@ -23685,8 +33423,15 @@ + The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. cardiac ventricle formation + + + + The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. + GOC:mtg_heart + @@ -23711,8 +33456,15 @@ + The process in which the left cardiac atrium is generated and organized. cardiac left atrium morphogenesis + + + + The process in which the left cardiac atrium is generated and organized. + GOC:mtg_heart + @@ -23737,8 +33489,15 @@ + The process in which the right cardiac atrium is generated and organized. cardiac right atrium morphogenesis + + + + The process in which the right cardiac atrium is generated and organized. + GOC:mtg_heart + @@ -23763,8 +33522,15 @@ + The process in which the left cardiac ventricle is generated and organized. cardiac left ventricle morphogenesis + + + + The process in which the left cardiac ventricle is generated and organized. + GOC:mtg_heart + @@ -23789,8 +33555,15 @@ + The process in which the right cardiac ventricle is generated and organized. cardiac right ventricle morphogenesis + + + + The process in which the right cardiac ventricle is generated and organized. + GOC:mtg_heart + @@ -23821,8 +33594,15 @@ + The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts. cardiac left atrium formation + + + + The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts. + GOC:mtg_heart + @@ -23853,8 +33633,15 @@ + The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts. cardiac right atrium formation + + + + The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts. + GOC:mtg_heart + @@ -23885,8 +33672,15 @@ + The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts. cardiac left ventricle formation + + + + The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts. + GOC:mtg_heart + @@ -23917,8 +33711,15 @@ + The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts. cardiac right ventricle formation + + + + The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts. + GOC:mtg_heart + @@ -23949,8 +33750,15 @@ + The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized. left ventricular cardiac muscle tissue morphogenesis + + + + The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized. + GOC:mtg_heart + @@ -23981,8 +33789,117 @@ + The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized. right ventricular cardiac muscle tissue morphogenesis + + + + The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized. + GOC:mtg_heart + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. + ventricular trabecula myocardium morphogenesis + + + + + The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. + GOC:mtg_heart + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized. + left ventricular trabecular myocardium morphogenesis + + + + + The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized. + GOC:mtg_heart + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the anatomical structures of the right ventricular myocardium are generated and organized. + right ventricular trabecular myocardium morphogenesis + + + + + The process in which the anatomical structures of the right ventricular myocardium are generated and organized. + GOC:mtg_heart + @@ -24007,8 +33924,15 @@ + The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure. atrial cardiac muscle tissue development + + + + The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure. + GOC:mtg_heart + @@ -24033,8 +33957,15 @@ + The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. ventricular cardiac muscle tissue development + + + + The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. + GOC:mtg_heart + @@ -24059,8 +33990,15 @@ + The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. cardiac atrium development + + + + The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. + GOC:mtg_heart + @@ -24085,8 +34023,15 @@ + The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. cardiac ventricle development + + + + The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. + GOC:mtg_heart + @@ -24111,8 +34056,15 @@ + The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. sinus venosus development + + + + The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. + GOC:mtg_heart + @@ -24143,8 +34095,15 @@ + The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. sinus venosus morphogenesis + + + + The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. + GOC:mtg_heart + @@ -24175,8 +34134,15 @@ + The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. sinus venosus formation + + + + The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. + GOC:mtg_heart + @@ -24207,8 +34173,15 @@ + Developmental growth that contributes to the shaping of the heart. growth involved in heart morphogenesis + + + + Developmental growth that contributes to the shaping of the heart. + GOC:mtg_heart + @@ -24234,8 +34207,15 @@ + The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart. cardiac muscle tissue growth involved in heart morphogenesis + + + + The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart. + GOC:mtg_heart + @@ -24272,8 +34252,15 @@ + The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle. heart capillary growth + + + + The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle. + GOC:mtg_heart + @@ -24299,8 +34286,15 @@ + The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract. cardiac neural crest cell migration involved in outflow tract morphogenesis + + + + The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract. + GOC:mtg_heart + @@ -24325,8 +34319,15 @@ + The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. cardioblast migration + + + + The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. + GOC:mtg_heart + @@ -24357,8 +34358,16 @@ + The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. endocardial cushion formation + + + + The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. + GOC:mtg_heart + PMID:15797462 + @@ -24383,8 +34392,15 @@ + The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. cell migration involved in endocardial cushion formation + + + + The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. + GOC:mtg_heart + @@ -24409,8 +34425,16 @@ + Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries. apoptotic process involved in outflow tract morphogenesis + + + + Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries. + GOC:mtg_apoptosis + GOC:mtg_heart + @@ -24435,8 +34459,16 @@ + Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. apoptotic process involved in endocardial cushion morphogenesis + + + + Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. + GOC:mtg_apoptosis + GOC:mtg_heart + @@ -24461,8 +34493,16 @@ + Any apoptotic process that contributes to the shaping of the heart. apoptotic process involved in heart morphogenesis + + + + Any apoptotic process that contributes to the shaping of the heart. + GOC:mtg_apoptosis + GOC:mtg_heart + @@ -24493,8 +34533,15 @@ + The progression of a cardiac septum over time, from its initial formation to the mature structure. cardiac septum development + + + + The progression of a cardiac septum over time, from its initial formation to the mature structure. + GOC:mtg_heart + @@ -24525,8 +34572,15 @@ + The progression of the ventricular septum over time from its formation to the mature structure. ventricular septum development + + + + The progression of the ventricular septum over time from its formation to the mature structure. + GOC:mtg_heart + @@ -24557,8 +34611,15 @@ + The progression of the atrial septum over time, from its initial formation to the mature structure. atrial septum development + + + + The progression of the atrial septum over time, from its initial formation to the mature structure. + GOC:mtg_heart + @@ -24589,8 +34650,15 @@ + The process in which an endocardial cushion cell becomes a cell of a cardiac septum. cardiac septum cell differentiation + + + + The process in which an endocardial cushion cell becomes a cell of a cardiac septum. + GOC:mtg_heart + @@ -24598,8 +34666,15 @@ + The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development. physiological muscle hypertrophy + + + + The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development. + GOC:mtg_heart + @@ -24607,8 +34682,15 @@ + The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. cardiac muscle hypertrophy + + + + The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. + GOC:mtg_heart + @@ -24623,8 +34705,178 @@ + The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart. physiological cardiac muscle hypertrophy + + + + The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_heart + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + type B pancreatic cell differentiation + + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + CL:0000169 + GOC:dph + PMID:11076772 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. + pancreatic A cell differentiation + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. + GOC:dph + PMID:11076772 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin. + pancreatic D cell differentiation + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin. + GOC:dph + PMID:11076772 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. + pancreatic PP cell differentiation + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. + GOC:dph + PMID:11076772 + @@ -24655,8 +34907,15 @@ + The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. heart rudiment development + + + + The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. + GOC:mtg_heart + @@ -24688,8 +34947,15 @@ + The process in which the anatomical structures of the heart rudiment are generated and organized. heart rudiment morphogenesis + + + + The process in which the anatomical structures of the heart rudiment are generated and organized. + GOC:mtg_heart + @@ -24720,8 +34986,172 @@ + The developmental process pertaining to the initial formation of the heart rudiment. heart rudiment formation + + + + The developmental process pertaining to the initial formation of the heart rudiment. + GOC:mtg_heart + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon. + pancreatic A cell development + + + + + The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + type B pancreatic cell development + + + + + The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + CL:0000169 + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin. + pancreatic D cell development + + + + + The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. + pancreatic PP cell development + + + + + The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. + GOC:dph + @@ -24918,8 +35348,17 @@ + The directed, self-propelled movement of a cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. cilium movement + + + + The directed, self-propelled movement of a cilium. + GOC:dph + GOC:jl + @@ -24950,8 +35389,16 @@ + The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum. proepicardium development + + + + The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum. + GOC:dph + PMID:18722343 + @@ -24976,8 +35423,16 @@ + The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme. septum transversum development + + + + The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme. + GOC:dph + PMID:18722343 + @@ -25009,8 +35464,16 @@ + The process in which the anatomical structure of the pericardium is generated and organized. pericardium morphogenesis + + + + The process in which the anatomical structure of the pericardium is generated and organized. + GOC:dph + PMID:18722343 + @@ -25036,8 +35499,16 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. cardiac endothelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. + GOC:dph + PMID:18722343 + @@ -25062,8 +35533,16 @@ + Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. regulation of cilium movement + + + + Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + GOC:dph + @@ -25089,8 +35568,16 @@ + Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. positive regulation of cilium movement + + + + Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + GOC:dph + @@ -25116,8 +35603,16 @@ + Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. negative regulation of cilium movement + + + + Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + GOC:dph + @@ -25142,8 +35637,15 @@ + The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. brainstem development + + + + The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. + GOC:dph + @@ -25194,8 +35696,17 @@ + The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell. establishment of cell polarity involved in ameboidal cell migration + + + + The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25220,8 +35731,17 @@ + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell. establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration + + + + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25246,8 +35766,17 @@ + The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation. establishment of cell polarity involved in gastrulation cell migration + + + + The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25272,8 +35801,17 @@ + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation. establishment or maintenance of cytoskeleton polarity involved in gastrulation + + + + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25298,8 +35836,17 @@ + The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation. epithelial cell morphogenesis involved in gastrulation + + + + The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25330,8 +35877,17 @@ + The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. epithelial cell morphogenesis + + + + The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25368,8 +35924,17 @@ + The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. optic vesicle formation + + + + The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25401,8 +35966,17 @@ + The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. optic vesicle morphogenesis + + + + The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25433,8 +36007,17 @@ + The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. neural retina development + + + + The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25459,8 +36042,17 @@ + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye. cell motility involved in camera-type eye morphogenesis + + + + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25485,8 +36077,17 @@ + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. chondrocyte differentiation involved in endochondral bone morphogenesis + + + + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25511,8 +36112,17 @@ + The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized. chondrocyte morphogenesis involved in endochondral bone morphogenesis + + + + The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25537,8 +36147,17 @@ + The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. endochondral bone growth + + + + The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25563,8 +36182,385 @@ + The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. chondrocyte development involved in endochondral bone morphogenesis + + + + The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. + GOC:ascb_2009 + GOC:dph + GOC:tb + + + + + + + + + + + A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. + Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. + molecular_function + + + + + A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. + GOC:pdt + + + + + + + + + Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. + Wikipedia:Enzyme + catalytic activity + + + + + Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. + GOC:vw + ISBN:0198506732 + + + + + + + + + Catalysis of the hydrolysis of ester linkages within nucleic acids. + Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. + nuclease activity + + + + + Catalysis of the hydrolysis of ester linkages within nucleic acids. + ISBN:0198547684 + + + + + + + + + + + + + + + + Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. + Reactome:R-HSA-211247 + Reactome:R-HSA-5685994 + Reactome:R-HSA-6785986 + DNA nuclease activity + + + + + Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. + GOC:mah + ISBN:0198547684 + + + + + Reactome:R-HSA-211247 + Cleavage of DNA by DFF40 + + + + + Reactome:R-HSA-5685994 + Long-range resection of DNA DSBs by EXO1 or DNA2 + + + + + Reactome:R-HSA-6785986 + DNA nucleases unhook the interstrand crosslink (ICL) + + + + + + + + + Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells. + Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. + transporter activity + + + + + Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells. + GOC:ai + GOC:dgf + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. + amine transmembrane transporter activity + + + + + Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. + GOC:mtg_transport + ISBN:0198506732 + ISBN:0815340729 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the directed movement of lipids into, out of or within a cell, or between cells. + Reactome:R-HSA-1369028 + Reactome:R-HSA-1369052 + Reactome:R-HSA-174786 + Reactome:R-HSA-5682285 + Reactome:R-HSA-5682311 + Reactome:R-HSA-5683672 + Reactome:R-HSA-5683714 + Reactome:R-HSA-5688397 + Reactome:R-HSA-6801250 + Reactome:R-HSA-8848053 + Reactome:R-HSA-8866329 + lipid transporter activity + + + + + Enables the directed movement of lipids into, out of or within a cell, or between cells. + GOC:ai + + + + + Reactome:R-HSA-1369028 + ABCAs mediate lipid efflux + + + + + Reactome:R-HSA-1369052 + ABCAs mediate lipid influx + + + + + Reactome:R-HSA-174786 + ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex + + + + + Reactome:R-HSA-5682285 + ABCA12 transports lipids from cytosol to extracellular region + + + + + Reactome:R-HSA-5682311 + Defective ABCA12 does not transport lipids from cytosol to extracellular region + + + + + Reactome:R-HSA-5683672 + Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body + + + + + Reactome:R-HSA-5683714 + ABCA3 transports PC, PG from ER membrane to lamellar body + + + + + Reactome:R-HSA-5688397 + Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body + + + + + Reactome:R-HSA-6801250 + TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane + + + + + Reactome:R-HSA-8848053 + ABCA5 transports CHOL from lysosomal lumen to cytosol + + + + + Reactome:R-HSA-8866329 + MTTP lipidates APOB-100, forming a pre-VLDL + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage. + organic acid transmembrane transporter activity + + + + + Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. + Reactome:R-HSA-499981 + Reactome:R-HSA-5653873 + glucose transmembrane transporter activity + + + + + Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. + GOC:ai + GOC:mtg_transport + ISBN:0815340729 + + + + + Reactome:R-HSA-499981 + Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 + + + + + Reactome:R-HSA-5653873 + SLC2A1 tetramer transports Glc from cytosol to Golgi lumen + @@ -25573,8 +36569,17 @@ + A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). + NIF_Subcellular:sao1337158144 + Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. cellular_component + + + + A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). + GOC:pdt + @@ -25582,8 +36587,17 @@ + The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. + Wikipedia:Extracellular + Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. extracellular region + + + + The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. + GOC:go_curators + @@ -25597,8 +36611,15 @@ + A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. fibrinogen complex + + + + A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. + ISBN:0198547684 + @@ -25618,8 +36639,20 @@ + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. + Wikipedia:Collagen collagen trimer + + + + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. + GOC:dos + GOC:mah + ISBN:0721639976 + PMID:19693541 + PMID:21421911 + @@ -25645,8 +36678,17 @@ + Any triple helical collagen trimer that forms fibrils. fibrillar collagen trimer + + + + Any triple helical collagen trimer that forms fibrils. + GOC:mah + ISBN:0721639976 + PMID:21421911 + @@ -25654,8 +36696,16 @@ + A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. + Wikipedia:Collagen_type_II collagen type II trimer + + + + A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. + ISBN:0721639976 + @@ -25664,8 +36714,18 @@ + A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. + Wikipedia:Collagen_type_IV collagen type IV trimer + + + + A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. + ISBN:0721639976 + PMID:19693541 + PMID:21421911 + @@ -25673,8 +36733,18 @@ + A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. + Wikipedia:Basement_membrane + Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. basement membrane + + + + A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. + ISBN:0198547684 + PMID:22505934 + @@ -25688,8 +36758,17 @@ + That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. + NIF_Subcellular:sao1425028079 + Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. extracellular space + + + + That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. + ISBN:0198547684 + @@ -25703,8 +36782,16 @@ + A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. + Wikipedia:Intracellular intracellular anatomical structure + + + + A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. + ISBN:0198506732 + @@ -25731,8 +36818,17 @@ + A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. + NIF_Subcellular:sao1702920020 + Wikipedia:Cell_nucleus nucleus + + + + A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. + GOC:go_curators + @@ -25752,8 +36848,16 @@ + The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). + Wikipedia:Nuclear_envelope nuclear envelope + + + + The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). + ISBN:0198547684 + @@ -25785,8 +36889,16 @@ + The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. + NIF_Subcellular:sao1617136075 nuclear outer membrane + + + + The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. + ISBN:0198547684 + @@ -25794,8 +36906,17 @@ + A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. + Wikipedia:Chromosome + Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. chromosome + + + + A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. + ISBN:0198547684 + @@ -25809,8 +36930,17 @@ + A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. + NIF_Subcellular:sao1820400233 + Wikipedia:Nucleolus nucleolus + + + + A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. + ISBN:0198506732 + @@ -25824,8 +36954,16 @@ + The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + Wikipedia:Cytoplasm cytoplasm + + + + The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + ISBN:0198547684 + @@ -25859,8 +36997,18 @@ + A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. + NIF_Subcellular:sao585356902 + Wikipedia:Lysosome lysosome + + + + A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. + GOC:mah + ISBN:0198506732 + @@ -25917,8 +37065,15 @@ + The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. lysosomal membrane + + + + The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. + GOC:ai + @@ -25926,8 +37081,17 @@ + A lysosome before it has fused with a vesicle or vacuole. + NIF_Subcellular:sao1140587416 primary lysosome + + + + A lysosome before it has fused with a vesicle or vacuole. + GOC:jl + ISBN:0815316194 + @@ -25941,8 +37105,17 @@ + A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. + Wikipedia:Vacuole vacuole + + + + A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. + GOC:mtg_sensu + ISBN:0198506732 + @@ -25973,8 +37146,15 @@ + The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. vacuolar membrane + + + + The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. + GOC:ai + @@ -25999,8 +37179,15 @@ + The volume enclosed within the vacuolar membrane. vacuolar lumen + + + + The volume enclosed within the vacuolar membrane. + ISBN:0198506732 + @@ -26032,8 +37219,18 @@ + A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. + NIF_Subcellular:sao451912436 + Wikipedia:Golgi_apparatus + Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. Golgi apparatus + + + + A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. + ISBN:0198506732 + @@ -26041,8 +37238,17 @@ + Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. + NIF_Subcellular:sao819927218 + Note that this definition includes vesicles that are transiently associated with the Golgi. Golgi-associated vesicle + + + + Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. + GOC:mah + @@ -26068,8 +37274,17 @@ + An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. + NIF_Subcellular:sao1429207766 + Wikipedia:Ribosome ribosome + + + + An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. + ISBN:0198506732 + @@ -26077,8 +37292,18 @@ + A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. + Wikipedia:Cytoskeleton cytoskeleton + + + + A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. + GOC:mah + PMID:16959967 + PMID:27419875 + @@ -26092,8 +37317,17 @@ + Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. + NIF_Subcellular:sao1846835077 + Wikipedia:Microtubule microtubule + + + + Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. + ISBN:0879693568 + @@ -26118,8 +37352,16 @@ + A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. axonemal microtubule + + + + A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. + GOC:cilia + ISBN:0815316194 + @@ -26144,8 +37386,15 @@ + Any microtubule in the nucleus of a cell. nuclear microtubule + + + + Any microtubule in the nucleus of a cell. + GOC:mah + @@ -26170,8 +37419,15 @@ + Any microtubule in the cytoplasm of a cell. cytoplasmic microtubule + + + + Any microtubule in the cytoplasm of a cell. + GOC:mah + @@ -26185,8 +37441,20 @@ + A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. + FMA:63850 + NIF_Subcellular:sao1588493326 + Wikipedia:Actin actin filament + + + + A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. + GOC:mah + ISBN:0198506732 + PMID:10666339 + @@ -26200,8 +37468,17 @@ + The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. + NIF_Subcellular:sao1663586795 + Wikipedia:Cell_membrane plasma membrane + + + + The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. + ISBN:0716731363 + @@ -26247,8 +37524,18 @@ + Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. + NIF_Subcellular:sao671419673 + Wikipedia:Microvillus + Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. microvillus + + + + Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. + ISBN:0815316194 + @@ -26256,8 +37543,22 @@ + A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. + NIF_Subcellular:sao1922892319 cell-cell junction + + + + A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. + GOC:aruk + GOC:bc + GOC:dgh + GOC:hb + GOC:mah + PMID:21422226 + PMID:28096264 + @@ -26440,8 +37741,26 @@ + A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. + FMA:67181 + NIF_Subcellular:sao787716553 + Wikipedia:Cilium + Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. cilium + + + + A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. + GOC:cilia + GOC:curators + GOC:kmv + GOC:vw + ISBN:0198547684 + PMID:16824949 + PMID:17009929 + PMID:20144998 + @@ -26467,8 +37786,19 @@ + The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. + Wikipedia:Axoneme + Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. axoneme + + + + The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. + GOC:bf + GOC:cilia + ISBN:0198547684 + @@ -26493,8 +37823,17 @@ + The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. + Wikipedia:Cell_cortex cell cortex + + + + The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. + GOC:mah + ISBN:0815316194 + @@ -26519,8 +37858,17 @@ + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + Wikipedia:Carbohydrate_metabolism carbohydrate metabolic process + + + + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + GOC:mah + ISBN:0198506732 + @@ -26545,8 +37893,257 @@ + The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. polysaccharide metabolic process + + + + The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + ISBN:0198547684 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. + glycogen metabolic process + + + + + The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + MetaCyc:GLYCOGENSYNTH-PWY + MetaCyc:PWY-5067 + MetaCyc:PWY-7900 + glycogen biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + regulation of glycogen biosynthetic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + MetaCyc:GLYCOCAT-PWY + MetaCyc:PWY-5941 + MetaCyc:PWY-7662 + glycogen catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + regulation of glycogen catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. + glucose metabolic process + + + + + The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. + glucose catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. + GOC:ai + @@ -26571,8 +38168,133 @@ + The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. glycosaminoglycan biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. + ISBN:0192800981 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. + glycosaminoglycan catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. + ISBN:0192800981 + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. + organic acid metabolic process + + + + + The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. + ISBN:0198506732 + + + + + + + + + The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. + generation of precursor metabolites and energy + + + + + The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. + MetaCyc:GLUCONEO-PWY + Wikipedia:Gluconeogenesis + gluconeogenesis + + + + + The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. + MetaCyc:GLUCONEO-PWY + @@ -26597,8 +38319,64 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. regulation of carbohydrate metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. + regulation of gluconeogenesis + + + + + Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. + GOC:go_curators + + + + + + + + + The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. + energy reserve metabolic process + + + + + The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. + GOC:mah + @@ -26623,8 +38401,15 @@ + Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. nucleobase-containing compound metabolic process + + + + Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:ai + @@ -26649,8 +38434,95 @@ + Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. DNA metabolic process + + + + Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. + DNA catabolic process + + + + + The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. + GOC:go_curators + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. + DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). + apoptotic DNA fragmentation + + + + + The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. + GOC:dph + GOC:mah + GOC:mtg_apoptosis + GOC:tb + ISBN:0721639976 + PMID:15723341 + PMID:23379520 + @@ -26675,8 +38547,48 @@ + The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. chromatin organization + + + + The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. + PMID:20404130 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. + RNA catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. + ISBN:0198506732 + @@ -26684,8 +38596,15 @@ + A process in which RNA is transported to, or maintained in, a specific location. RNA localization + + + + A process in which RNA is transported to, or maintained in, a specific location. + GOC:ai + @@ -26739,8 +38658,16 @@ + The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. + Wikipedia:Translation_(genetics) translation + + + + The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. + GOC:go_curators + @@ -26760,8 +38687,15 @@ + The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. translational initiation + + + + The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. + ISBN:019879276X + @@ -26775,8 +38709,15 @@ + The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. translational elongation + + + + The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. + GOC:ems + @@ -26790,8 +38731,16 @@ + The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). translational termination + + + + The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). + GOC:hjd + ISBN:019879276X + @@ -26817,8 +38766,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. regulation of translation + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. + GOC:isa_complete + @@ -26843,8 +38799,15 @@ + Any process that modulates the frequency, rate or extent of translational initiation. regulation of translational initiation + + + + Any process that modulates the frequency, rate or extent of translational initiation. + GOC:go_curators + @@ -26869,8 +38832,15 @@ + Any process that modulates the frequency, rate, extent or accuracy of translational elongation. regulation of translational elongation + + + + Any process that modulates the frequency, rate, extent or accuracy of translational elongation. + GOC:go_curators + @@ -26896,8 +38866,49 @@ + Any process that modulates the frequency, rate or extent of translational termination. regulation of translational termination + + + + Any process that modulates the frequency, rate or extent of translational termination. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + glycoprotein catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:go_curators + ISBN:0198506732 + @@ -26922,8 +38933,15 @@ + The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. peptide metabolic process + + + + The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. + GOC:go_curators + @@ -26931,8 +38949,16 @@ + The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. biogenic amine metabolic process + + + + The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. + GOC:jl + ISBN:0395825172 + @@ -26958,8 +38984,16 @@ + The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. catecholamine metabolic process + + + + The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:jl + ISBN:0198506732 + @@ -26984,8 +39018,132 @@ + The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. + Wikipedia:Lipid_metabolism lipid metabolic process + + + + The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. + GOC:ma + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. + Wikipedia:Steroid_metabolisms#Steroid_biosynthesis + steroid biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. + bile acid biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + steroid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:go_curators + @@ -26993,8 +39151,19 @@ + The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. + Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. transport + + + + The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. + GOC:dos + GOC:dph + GOC:jl + GOC:mah + @@ -27019,8 +39188,15 @@ + The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. monoatomic ion transport + + + + The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + GOC:ai + @@ -27045,8 +39221,15 @@ + The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. serotonin transport + + + + The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. + GOC:ai + @@ -27071,8 +39254,15 @@ + The transport of substances that occurs outside cells. extracellular transport + + + + The transport of substances that occurs outside cells. + GOC:go_curators + @@ -27103,8 +39293,48 @@ + The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. lipid transport + + + + The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + intracellular monoatomic ion homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + GOC:mah + @@ -27134,8 +39364,15 @@ + The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. intracellular protein transport + + + + The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. + GOC:mah + @@ -27167,8 +39404,18 @@ + A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. + Wikipedia:Exocytosis exocytosis + + + + A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. + GOC:mah + ISBN:0716731363 + PMID:22323285 + @@ -27176,8 +39423,16 @@ + The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. post-Golgi vesicle-mediated transport + + + + The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. + GOC:ai + GOC:mah + @@ -27207,8 +39462,15 @@ + The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. Golgi to plasma membrane transport + + + + The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. + ISBN:0716731363 + @@ -27248,8 +39510,15 @@ + The directed movement of substances from the Golgi to the vacuole. Golgi to vacuole transport + + + + The directed movement of substances from the Golgi to the vacuole. + GOC:ai + @@ -27276,8 +39545,19 @@ + A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle. + Wikipedia:Endocytosis endocytosis + + + + A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle. + GOC:mah + ISBN:0198506732 + ISBN:0716731363 + Wikipedia:Endocytosis + @@ -27292,8 +39572,16 @@ + The evagination of a membrane, resulting in formation of a vesicle. vesicle budding from membrane + + + + The evagination of a membrane, resulting in formation of a vesicle. + GOC:jid + GOC:tb + @@ -27313,8 +39601,16 @@ + The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. vesicle targeting + + + + The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. + GOC:mah + PMID:17335816 + @@ -27346,8 +39642,15 @@ + Fusion of the membrane of a transport vesicle with its target membrane. vesicle fusion + + + + Fusion of the membrane of a transport vesicle with its target membrane. + GOC:jid + @@ -27381,8 +39684,16 @@ + A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. + Wikipedia:Phagocytosis phagocytosis + + + + A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. + ISBN:0198506732 + @@ -27466,8 +39777,24 @@ + A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. + Wikipedia:Apoptosis apoptotic process + + + + A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. + GOC:cjm + GOC:dhl + GOC:ecd + GOC:go_curators + GOC:mtg_apoptosis + GOC:tb + ISBN:0198506732 + PMID:18846107 + PMID:21494263 + @@ -27492,8 +39819,18 @@ + The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. cellular component disassembly involved in execution phase of apoptosis + + + + The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. + GOC:dph + GOC:mah + GOC:mtg_apoptosis + GOC:tb + @@ -27501,8 +39838,16 @@ + Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage. inflammatory cell apoptotic process + + + + Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage. + GOC:jl + GOC:mtg_apoptosis + @@ -27516,8 +39861,16 @@ + The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). + Wikipedia:Chemotaxis chemotaxis + + + + The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). + ISBN:0198506732 + @@ -27531,8 +39884,18 @@ + A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. + Wikipedia:Muscle_contraction muscle contraction + + + + A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. + GOC:ef + GOC:mtg_muscle + ISBN:0198506732 + @@ -27557,8 +39920,15 @@ + Any process that modulates the frequency, rate or extent of muscle contraction. regulation of muscle contraction + + + + Any process that modulates the frequency, rate or extent of muscle contraction. + GOC:go_curators + @@ -27583,8 +39953,18 @@ + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. smooth muscle contraction + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. + GOC:ef + GOC:jl + GOC:mtg_muscle + ISBN:0198506732 + @@ -27609,8 +39989,15 @@ + Any process that modulates the frequency, rate or extent of smooth muscle contraction. regulation of smooth muscle contraction + + + + Any process that modulates the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators + @@ -27624,8 +40011,17 @@ + A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. striated muscle contraction + + + + A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. + GOC:jl + GOC:mtg_muscle + ISBN:0198506732 + @@ -27650,8 +40046,15 @@ + Any process that modulates the frequency, rate or extent of striated muscle contraction. regulation of striated muscle contraction + + + + Any process that modulates the frequency, rate or extent of striated muscle contraction. + GOC:go_curators + @@ -27677,8 +40080,15 @@ + The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. syncytium formation + + + + The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. + ISBN:0198506732 + @@ -27686,8 +40096,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to stress + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + GOC:mah + @@ -27695,8 +40113,15 @@ + Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. defense response + + + + Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. + GOC:go_curators + @@ -27716,8 +40141,17 @@ + The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. + Wikipedia:Inflammation inflammatory response + + + + The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. + GO_REF:0000022 + ISBN:0198506732 + @@ -27726,8 +40160,16 @@ + Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. immune response + + + + Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. + GOC:add + GO_REF:0000022 + @@ -27752,8 +40194,16 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. organelle organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + GOC:mah + @@ -27778,8 +40228,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. nucleus organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. + GOC:dph + GOC:ems + GOC:jl + GOC:mah + @@ -27816,8 +40276,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. nuclear envelope organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. + GOC:dph + GOC:ems + GOC:jl + GOC:mah + @@ -27842,8 +40312,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus. nucleolus organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus. + GOC:dph + GOC:jid + GOC:jl + GOC:mah + @@ -27874,8 +40354,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. plasma membrane organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. + GOC:dph + GOC:jl + GOC:mah + @@ -27900,8 +40389,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. + GOC:dph + GOC:jl + GOC:mah + @@ -27932,8 +40430,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. actin filament organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. + GOC:mah + @@ -27958,8 +40463,15 @@ + Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. microtubule-based process + + + + Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. + GOC:mah + @@ -27967,8 +40479,16 @@ + A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. microtubule-based movement + + + + A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. + GOC:cjm + ISBN:0815316194 + @@ -27994,8 +40514,15 @@ + The removal of tubulin heterodimers from one or both ends of a microtubule. microtubule depolymerization + + + + The removal of tubulin heterodimers from one or both ends of a microtubule. + ISBN:0815316194 + @@ -28009,8 +40536,18 @@ + The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). + Wikipedia:Microtubule_nucleation microtubule nucleation + + + + The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). + GOC:go_curators + ISBN:0815316194 + PMID:12517712 + @@ -28037,8 +40574,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. negative regulation of microtubule depolymerization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. + GOC:mah + ISBN:0815316194 + @@ -28065,8 +40610,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme. negative regulation of axonemal microtubule depolymerization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme. + GOC:dph + GOC:mah + @@ -28091,8 +40644,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. cytoplasm organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + GOC:curators + GOC:dph + GOC:jl + GOC:mah + @@ -28123,8 +40686,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. Golgi organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. + GOC:dph + GOC:jl + GOC:mah + @@ -28149,8 +40721,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. vacuole organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. + GOC:mah + @@ -28175,8 +40754,49 @@ + The directed movement of substances into, out of or within a vacuole. vacuolar transport + + + + The directed movement of substances into, out of or within a vacuole. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. + protein catabolic process in the vacuole + + + + + The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. + GOC:mah + GOC:vw + @@ -28227,8 +40847,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. lysosome organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. + GOC:mah + @@ -28279,8 +40906,15 @@ + The directed movement of substances into, out of or within a lysosome. lysosomal transport + + + + The directed movement of substances into, out of or within a lysosome. + GOC:ai + @@ -28305,8 +40939,15 @@ + The aggregation, arrangement and bonding together of a set of components to form a junction between cells. cell-cell junction assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a junction between cells. + GOC:ai + @@ -28314,8 +40955,17 @@ + The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. + Wikipedia:Cell_cycle cell cycle + + + + The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. + GOC:go_curators + GOC:mtg_cell_cycle + @@ -28323,8 +40973,19 @@ + The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. + Wikipedia:Chromosome_segregation chromosome segregation + + + + The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. + GOC:jl + GOC:mah + GOC:mtg_cell_cycle + GOC:vw + @@ -28350,8 +41011,16 @@ + The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. mitotic chromosome condensation + + + + The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. + GOC:mah + ISBN:0815316194 + @@ -28371,8 +41040,16 @@ + The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis. mitotic nuclear membrane disassembly + + + + The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis. + GOC:bf + PMID:32848252 + @@ -28399,8 +41076,15 @@ + Any process that modulates the frequency, rate or extent of mitosis. regulation of mitotic nuclear division + + + + Any process that modulates the frequency, rate or extent of mitosis. + GOC:go_curators + @@ -28421,8 +41105,15 @@ + The directed movement of the nucleus to a specific location within a cell. nuclear migration + + + + The directed movement of the nucleus to a specific location within a cell. + GOC:ai + @@ -28430,8 +41121,19 @@ + A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell. + Wikipedia:Mitosis#Endomitosis + Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins. endomitotic cell cycle + + + + A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell. + GOC:curators + GOC:dos + GOC:expert_vm + @@ -28486,8 +41188,19 @@ + A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. + Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. female meiotic nuclear division + + + + A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. + GOC:dph + GOC:ems + GOC:mah + GOC:vw + @@ -28495,8 +41208,16 @@ + Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + Wikipedia:Cell_signaling cell communication + + + + Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:mah + @@ -28504,8 +41225,17 @@ + The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. + Wikipedia:Cell_adhesion cell adhesion + + + + The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. + GOC:hb + GOC:pf + @@ -28548,8 +41278,15 @@ + The attachment of a leukocyte to another cell via adhesion molecules. leukocyte cell-cell adhesion + + + + The attachment of a leukocyte to another cell via adhesion molecules. + GOC:go_curators + @@ -28575,8 +41312,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. negative regulation of cell adhesion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. + GOC:go_curators + @@ -28584,8 +41328,15 @@ + Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. establishment or maintenance of cell polarity + + + + Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. + GOC:mah + @@ -28612,8 +41363,18 @@ + The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. + Wikipedia:Signal_transduction + Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. signal transduction + + + + The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. + GOC:go_curators + GOC:mtg_signaling_feb11 + @@ -28622,8 +41383,16 @@ + Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. cell-cell signaling + + + + Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. + GOC:dos + GOC:mah + @@ -28637,8 +41406,17 @@ + The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. + Wikipedia:Neurotransmission chemical synaptic transmission + + + + The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. + GOC:jl + MeSH:D009435 + @@ -28664,8 +41442,19 @@ + The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + Note that this term was 'developmental process'. multicellular organism development + + + + The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:dph + GOC:ems + GOC:isa_complete + GOC:tb + @@ -28679,8 +41468,16 @@ + The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. gamete generation + + + + The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. + GOC:ems + GOC:mtg_sensu + @@ -28713,8 +41510,15 @@ + The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. germ cell development + + + + The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. + GOC:go_curators + @@ -28722,8 +41526,16 @@ + Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. female gamete generation + + + + Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. + GOC:dph + ISBN:0198506732 + @@ -28750,8 +41562,16 @@ + Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster. germarium-derived egg chamber formation + + + + Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster. + GOC:mtg_sensu + ISBN:0879694238 + @@ -28783,8 +41603,19 @@ + The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster. oocyte construction + + + + The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster. + GOC:dph + GOC:ems + GOC:mtg_sensu + GOC:tb + ISBN:0198506732 + @@ -28830,8 +41661,16 @@ + The union of male and female gametes to form a zygote. single fertilization + + + + The union of male and female gametes to form a zygote. + GOC:ems + GOC:mtg_sensu + @@ -28862,8 +41701,17 @@ + The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm. + Wikipedia:Egg_activation egg activation + + + + The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm. + GOC:bf + PMID:9630751 + @@ -28888,8 +41736,17 @@ + Any process that modulates the rate or extent of progress through the mitotic cell cycle. regulation of mitotic cell cycle + + + + Any process that modulates the rate or extent of progress through the mitotic cell cycle. + GOC:dph + GOC:go_curators + GOC:tb + @@ -28898,8 +41755,16 @@ + The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. blastoderm segmentation + + + + The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. + ISBN:0879694238 + http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm + @@ -28925,8 +41790,17 @@ + A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + Wikipedia:Gastrulation gastrulation + + + + A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + GOC:curators + ISBN:9780878933846 + @@ -28940,8 +41814,17 @@ + Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. pattern specification process + + + + Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. + GOC:go_curators + GOC:isa_complete + ISBN:0521436125 + @@ -28966,8 +41849,16 @@ + The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. ectoderm development + + + + The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. + GOC:dph + GOC:tb + @@ -28992,8 +41883,15 @@ + The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. nervous system development + + + + The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. + GOC:dgh + @@ -29036,8 +41934,17 @@ + The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. neuroblast proliferation + + + + The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. + GOC:ai + GOC:mtg_sensu + GOC:sart + @@ -29064,8 +41971,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. negative regulation of neuroblast proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. + GOC:ai + @@ -29102,8 +42016,16 @@ + A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. neuroblast activation + + + + A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. + GOC:go_curators + GOC:mtg_sensu + @@ -29134,8 +42056,16 @@ + The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). + Wikipedia:Synaptogenesis synapse assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). + GOC:mah + @@ -29166,8 +42096,18 @@ + The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. + Wikipedia:Neural_development central nervous system development + + + + The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. + GOC:bf + GOC:jid + ISBN:0582227089 + @@ -29204,8 +42144,18 @@ + The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). brain development + + + + The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). + GOC:dph + GOC:jid + GOC:tb + UBERON:0000955 + @@ -29236,8 +42186,16 @@ + The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. peripheral nervous system development + + + + The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. + GOC:go_curators + UBERON:0000010 + @@ -29262,8 +42220,15 @@ + The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. sensory organ development + + + + The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. + GOC:go_curators + @@ -29294,8 +42259,15 @@ + The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm. ectodermal digestive tract development + + + + The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm. + GOC:curators + @@ -29326,8 +42298,60 @@ + The process in which the anatomical structures of the foregut are generated and organized. foregut morphogenesis + + + + The process in which the anatomical structures of the foregut are generated and organized. + GOC:jid + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the anatomical structures of the hindgut are generated and organized. + hindgut morphogenesis + + + + + The process in which the anatomical structures of the hindgut are generated and organized. + GOC:jid + @@ -29352,8 +42376,50 @@ + The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. endoderm development + + + + The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. + midgut development + + + + + The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. + GOC:jid + UBERON:0001045 + @@ -29378,8 +42444,16 @@ + The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. mesoderm development + + + + The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. + GOC:dph + GOC:tb + @@ -29412,8 +42486,15 @@ + The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. gonadal mesoderm development + + + + The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. + GOC:ai + @@ -29444,9 +42525,17 @@ - + The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + Wikipedia:Heart_development heart development + + + + The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + GOC:jid + UBERON:0000948 + @@ -29472,8 +42561,16 @@ + The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. muscle organ development + + + + The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. + GOC:jid + ISBN:0198506732 + @@ -29504,8 +42601,15 @@ + The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. skeletal muscle tissue development + + + + The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. + GOC:mtg_muscle + @@ -29530,8 +42634,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. neuromuscular junction development + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. + GOC:mtg_OBO2OWL_2013 + @@ -29539,8 +42650,16 @@ + The establishment of the sex of an organism by physical differentiation. + Wikipedia:Sexual_differentiation sex differentiation + + + + The establishment of the sex of an organism by physical differentiation. + GOC:ai + @@ -29561,8 +42680,16 @@ + The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. + Wikipedia:Gestation female pregnancy + + + + The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. + ISBN:0192800825 + @@ -29582,8 +42709,16 @@ + Attachment of the blastocyst to the uterine lining. embryo implantation + + + + Attachment of the blastocyst to the uterine lining. + GOC:isa_complete + PMID:10882512 + @@ -29591,8 +42726,15 @@ + The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. respiratory gaseous exchange by respiratory system + + + + The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. + ISBN:0198506732 + @@ -29600,8 +42742,54 @@ + The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + Wikipedia:Digestion digestion + + + + The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:isa_complete + ISBN:0198506732 + + + + + + + + + The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. + Wikipedia:Excretion + excretion + + + + + The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. + ISBN:0192801023 + + + + + + + + + + The controlled release of a fluid by a cell or tissue in an animal. + body fluid secretion + + + + + The controlled release of a fluid by a cell or tissue in an animal. + GOC:ai + GOC:dph + GOC:mah + GOC:tb + @@ -29609,8 +42797,17 @@ + The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + Wikipedia:Perception sensory perception + + + + The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + GOC:dph + @@ -29618,8 +42815,16 @@ + The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. + Wikipedia:Visual_perception visual perception + + + + The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. + GOC:ai + @@ -29627,8 +42832,16 @@ + The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. + Wikipedia:Hearing_(sense) sensory perception of sound + + + + The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. + GOC:ai + @@ -29636,8 +42849,72 @@ + The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. sensory perception of chemical stimulus + + + + The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. + Wikipedia:Behavior + 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. +2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). + behavior + + + + + The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. + GOC:ems + GOC:jl + ISBN:0395448956 + PMID:20160973 + + + + + + + + + The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. + locomotory behavior + + + + + The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. + GOC:dph + @@ -29645,8 +42922,16 @@ + The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. blood circulation + + + + The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. + GOC:mtg_heart + ISBN:0192800825 + @@ -29671,8 +42956,17 @@ + Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. regulation of heart contraction + + + + Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. + GOC:dph + GOC:go_curators + GOC:tb + @@ -29697,8 +42991,20 @@ + The orderly movement of mesodermal cells from one site to another. mesodermal cell migration + + + + The orderly movement of mesodermal cells from one site to another. + GOC:ascb_2009 + GOC:dph + GOC:mah + GOC:sat + GOC:tb + PMID:25119047 + @@ -29727,8 +43033,16 @@ + The directed movement of organelles or molecules along microtubules in neuron projections. + Wikipedia:Axoplasmic_transport axo-dendritic transport + + + + The directed movement of organelles or molecules along microtubules in neuron projections. + ISBN:0815316194 + @@ -29753,8 +43067,15 @@ + Any process in which a protein is transported to, or maintained in, a specific location. protein localization + + + + Any process in which a protein is transported to, or maintained in, a specific location. + GOC:ai + @@ -29762,8 +43083,17 @@ + A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. + Wikipedia:Biological_process + Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. biological_process + + + + A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. + GOC:pdt + @@ -29772,8 +43102,87 @@ + The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. + Wikipedia:Metabolism + Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. metabolic process + + + + The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. + GOC:go_curators + ISBN:0198547684 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + Wikipedia:Steroid_metabolism + steroid metabolic process + + + + + The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + ISBN:0198547684 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + bile acid metabolic process + + + + + The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + GOC:go_curators + @@ -29781,8 +43190,18 @@ + Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). + This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. cell death + + + + Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). + GOC:mah + GOC:mtg_apoptosis + PMID:25236395 + @@ -29816,8 +43235,17 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. cell population proliferation + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + GOC:mah + GOC:mb + @@ -29849,8 +43277,15 @@ + Any process that activates or increases the rate or extent of cell proliferation. positive regulation of cell population proliferation + + + + Any process that activates or increases the rate or extent of cell proliferation. + GOC:go_curators + @@ -29882,8 +43317,193 @@ + Any process that stops, prevents or reduces the rate or extent of cell proliferation. negative regulation of cell population proliferation + + + + Any process that stops, prevents or reduces the rate or extent of cell proliferation. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a protein from one side of a membrane to the other. + Reactome:R-HSA-1268022 + Reactome:R-HSA-1299475 + Reactome:R-HSA-184269 + Reactome:R-HSA-3149434 + Reactome:R-HSA-5205661 + Reactome:R-HSA-5210943 + Reactome:R-HSA-5210947 + Reactome:R-HSA-5228406 + Reactome:R-HSA-5229111 + Reactome:R-HSA-5244404 + Reactome:R-HSA-5244428 + Reactome:R-HSA-5244506 + Reactome:R-HSA-5246514 + Reactome:R-HSA-5250616 + Reactome:R-HSA-5250884 + Reactome:R-HSA-5250972 + Reactome:R-HSA-5336420 + Reactome:R-HSA-9636375 + Reactome:R-HSA-9698930 + Reactome:R-HSA-9698933 + protein transmembrane transporter activity + + + + + Enables the transfer of a protein from one side of a membrane to the other. + GOC:jl + + + + + Reactome:R-HSA-1268022 + TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space + + + + + Reactome:R-HSA-1299475 + TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix + + + + + Reactome:R-HSA-184269 + Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex + + + + + Reactome:R-HSA-3149434 + Transport of GAG to the Plasma Membrane + + + + + Reactome:R-HSA-5205661 + Pink1 is recruited from the cytoplasm to the mitochondria + + + + + Reactome:R-HSA-5210943 + pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) + + + + + Reactome:R-HSA-5210947 + pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) + + + + + Reactome:R-HSA-5228406 + tetX HC transports tetX LC from target cell endosome membrane into cytosol + + + + + Reactome:R-HSA-5229111 + AP4 transports APP from trans-Golgi network to endosome lumen + + + + + Reactome:R-HSA-5244404 + botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5244428 + botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5244506 + botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5246514 + botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol + + + + + Reactome:R-HSA-5250616 + botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5250884 + botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5250972 + botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5336420 + DT fragment B transports DT fragment A from target cell endosome membrane + + + + + Reactome:R-HSA-9636375 + SecA2 transports SapM from cytoplasm to cytosol + + + + + Reactome:R-HSA-9698930 + HCMV C Nucleocapsid Translocation + + + + + Reactome:R-HSA-9698933 + HCMV B Nucleocapsid Translocation + @@ -29926,8 +43546,16 @@ + The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. glial cell migration + + + + The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. + GOC:jl + GOC:mtg_sensu + @@ -29958,8 +43586,16 @@ + The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form. germ cell migration + + + + The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form. + GOC:bf + GOC:jl + @@ -29967,8 +43603,16 @@ + The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. + Wikipedia:Asymmetric_cell_division asymmetric cell division + + + + The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. + PMID:11672519 + @@ -30000,8 +43644,16 @@ + The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. gonad development + + + + The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. + GOC:ems + ISBN:0198506732 + @@ -30035,8 +43687,16 @@ + The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. epidermis development + + + + The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. + GOC:go_curators + UBERON:0001003 + @@ -30093,8 +43753,17 @@ + The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. female gonad development + + + + The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. + GOC:dph + GOC:jid + GOC:tb + @@ -30125,8 +43794,16 @@ + The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. photoreceptor cell morphogenesis + + + + The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. + GOC:jid + GOC:mah + @@ -30151,8 +43828,15 @@ + The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. lipid biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + GOC:go_curators + @@ -30177,8 +43861,103 @@ + The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. carbohydrate transport + + + + The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. + Note that this term is not intended for use in annotating lateral movement within membranes. + hexose transmembrane transport + + + + + The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. + GOC:vw + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. + Wikipedia:Catabolism + catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. + ISBN:0198547684 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + macromolecule catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + @@ -30186,8 +43965,17 @@ + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + Wikipedia:Anabolism biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + GOC:curators + ISBN:0198547684 + @@ -30213,8 +44001,16 @@ + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. macromolecule biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + @@ -30239,8 +44035,16 @@ + The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. glycoprotein metabolic process + + + + The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:go_curators + ISBN:0198506732 + @@ -30265,8 +44069,83 @@ + The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. glycoprotein biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:go_curators + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + glucan biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. + glucan catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. + GOC:go_curators + @@ -30287,8 +44166,15 @@ + The controlled release of proteins from a cell. protein secretion + + + + The controlled release of proteins from a cell. + GOC:ai + @@ -30313,8 +44199,16 @@ + The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. amine metabolic process + + + + The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + GOC:jl + ISBN:0198506732 + @@ -30339,8 +44233,50 @@ + The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. amine biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + amine catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + GOC:jl + ISBN:0198506732 + @@ -30348,8 +44284,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. + Note that 'radiation' refers to electromagnetic radiation of any wavelength. response to radiation + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. + GOC:jl + Wikipedia:Electromagnetic_radiation + @@ -30374,8 +44319,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. response to light stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. + GOC:go_curators + ISBN:0582227089 + @@ -30416,8 +44369,17 @@ + The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). + Wikipedia:Fertilisation fertilization + + + + The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). + GOC:tb + ISBN:0198506732 + @@ -30426,8 +44388,15 @@ + The series of events in which an external stimulus is received by a cell and converted into a molecular signal. detection of external stimulus + + + + The series of events in which an external stimulus is received by a cell and converted into a molecular signal. + GOC:hb + @@ -30436,8 +44405,15 @@ + The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. detection of abiotic stimulus + + + + The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. + GOC:hb + @@ -30447,8 +44423,15 @@ + The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. detection of light stimulus + + + + The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. + GOC:go_curators + @@ -30456,8 +44439,16 @@ + The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. detection of visible light + + + + The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. + GOC:go_curators + ISBN:0198506732 + @@ -30471,8 +44462,15 @@ + The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. detection of chemical stimulus + + + + The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. + GOC:jl + @@ -30480,8 +44478,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to external stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. + GOC:hb + @@ -30489,8 +44495,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to biotic stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. + GOC:hb + @@ -30515,8 +44529,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. response to bacterium + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. + GOC:hb + @@ -30541,8 +44562,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. response to fungus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. + GOC:hb + @@ -30550,8 +44578,32 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to abiotic stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. + GOC:hb + + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. + response to toxic substance + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. + GOC:lr + @@ -30567,8 +44619,17 @@ + The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. + Wikipedia:Morphogenesis anatomical structure morphogenesis + + + + The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. + GOC:go_curators + ISBN:0521436125 + @@ -30593,8 +44654,16 @@ + The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. catechol-containing compound metabolic process + + + + The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. + GOC:sm + ISBN:0198547684 + @@ -30619,8 +44688,15 @@ + The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. catechol-containing compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. + GOC:go_curators + @@ -30628,8 +44704,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to endogenous stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. + GOC:sm + @@ -30689,8 +44773,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. response to hormone + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. + GOC:jl + @@ -30715,8 +44806,81 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. response to carbohydrate + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. + response to hexose + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. + response to glucose + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. + GOC:jl + @@ -30741,8 +44905,15 @@ + Any process that modulates the frequency, rate or extent of asymmetric cell division. regulation of asymmetric cell division + + + + Any process that modulates the frequency, rate or extent of asymmetric cell division. + GOC:lr + @@ -30767,8 +44938,18 @@ + The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + Wikipedia:Embryogenesis embryo development + + + + The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + GOC:go_curators + GOC:isa_complete + GOC:mtg_sensu + @@ -30782,8 +44963,15 @@ + The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. post-embryonic development + + + + The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. + GOC:go_curators + @@ -30803,8 +44991,17 @@ + The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. embryo development ending in birth or egg hatching + + + + The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. + GOC:go_curators + GOC:isa_complete + GOC:mtg_sensu + @@ -30818,8 +45015,16 @@ + The process that results in the patterns of cell differentiation that will arise in an embryo. embryonic pattern specification + + + + The process that results in the patterns of cell differentiation that will arise in an embryo. + GOC:go_curators + ISBN:0521436125 + @@ -30862,8 +45067,18 @@ + Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. animal organ morphogenesis + + + + Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:dgh + GOC:go_curators + ISBN:0471245208 + ISBN:0721662544 + @@ -31030,8 +45245,16 @@ + The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. + Wikipedia:Histogenesis tissue development + + + + The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. + ISBN:0471245208 + @@ -31056,8 +45279,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. regulation of biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators + @@ -31083,8 +45313,15 @@ + Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. negative regulation of biosynthetic process + + + + Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators + @@ -31110,8 +45347,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. positive regulation of biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators + @@ -31137,8 +45381,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. negative regulation of metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators + @@ -31164,8 +45415,116 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. positive regulation of metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. + regulation of catabolic process + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + negative regulation of catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + positive regulation of catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators + @@ -31196,8 +45555,19 @@ + The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. epidermal cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. + GOC:dph + GOC:go_curators + GOC:mtg_sensu + GOC:sdb_2009 + GOC:tb + @@ -31206,8 +45576,15 @@ + The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. hormone transport + + + + The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:tb + @@ -31215,8 +45592,18 @@ + The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. anterior/posterior pattern specification + + + + The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. + GOC:dph + GOC:go_curators + GOC:isa_complete + GOC:tb + @@ -31243,8 +45630,15 @@ + Any process that modulates the frequency, rate or extent of signal transduction. regulation of signal transduction + + + + Any process that modulates the frequency, rate or extent of signal transduction. + GOC:sm + @@ -31272,8 +45666,15 @@ + Any process that activates or increases the frequency, rate or extent of signal transduction. positive regulation of signal transduction + + + + Any process that activates or increases the frequency, rate or extent of signal transduction. + GOC:sm + @@ -31301,8 +45702,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. negative regulation of signal transduction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. + GOC:sm + @@ -31310,8 +45718,17 @@ + Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. cellular process + + + + Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:go_curators + GOC:isa_complete + @@ -31343,8 +45760,16 @@ + The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. oocyte differentiation + + + + The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. + GOC:go_curators + GOC:mtg_sensu + @@ -31387,8 +45812,16 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. glial cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. + GOC:go_curators + GOC:mtg_sensu + @@ -31414,8 +45847,15 @@ + The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. cardioblast differentiation + + + + The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. + GOC:go_curators + @@ -31435,8 +45875,15 @@ + Compaction of chromatin structure prior to meiosis in eukaryotic cells. meiotic chromosome condensation + + + + Compaction of chromatin structure prior to meiosis in eukaryotic cells. + PMID:10072401 + @@ -31461,8 +45908,15 @@ + The division of the zygote into two daughter cells that will adopt developmentally distinct potentials. zygote asymmetric cell division + + + + The division of the zygote into two daughter cells that will adopt developmentally distinct potentials. + GOC:tb + @@ -31494,8 +45948,17 @@ + The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. formation of animal organ boundary + + + + The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. + GOC:dph + GOC:isa_complete + PMID:9611175 + @@ -31520,8 +45983,16 @@ + The process in which the anatomical structures of the soma are generated and organized. body morphogenesis + + + + The process in which the anatomical structures of the soma are generated and organized. + GOC:ems + ISBN:0140512888 + @@ -31546,8 +46017,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to organonitrogen compound + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. + PMID:9869419 + @@ -31572,8 +46051,16 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. endomembrane system organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. + GOC:mah + GOC:sm + @@ -31581,8 +46068,15 @@ + The infolding of a membrane. membrane invagination + + + + The infolding of a membrane. + GOC:tb + @@ -31608,8 +46102,16 @@ + Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. regulation of cell fate commitment + + + + Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. + GOC:dph + GOC:tb + @@ -31635,8 +46137,16 @@ + Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. negative regulation of cell fate commitment + + + + Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. + GOC:dph + GOC:tb + @@ -31662,8 +46172,16 @@ + Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. positive regulation of cell fate commitment + + + + Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. + GOC:dph + GOC:tb + @@ -31688,8 +46206,16 @@ + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. mesenchymal cell proliferation + + + + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:dph + GOC:tb + @@ -31714,8 +46240,16 @@ + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. regulation of mesenchymal cell proliferation + + + + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:dph + GOC:tb + @@ -31723,8 +46257,18 @@ + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. + Wikipedia:Gene_expression gene expression + + + + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. + GOC:txnOH-2018 + PMID:25934543 + PMID:31580950 + @@ -31749,8 +46293,17 @@ + Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + Wikipedia:Regulation_of_gene_expression + This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. regulation of gene expression + + + + Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + GOC:txnOH-2018 + @@ -31776,8 +46329,16 @@ + Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. regulation of gastrulation + + + + Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. + GOC:dph + GOC:tb + @@ -31802,8 +46363,15 @@ + Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells. epidermal cell division + + + + Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells. + PMID:17450124 + @@ -31828,8 +46396,15 @@ + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis. regulation of epidermal cell division + + + + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis. + PMID:17450124 + @@ -31875,8 +46450,15 @@ + The movement of substances between cells. intercellular transport + + + + The movement of substances between cells. + GOC:dhl + @@ -31901,8 +46483,16 @@ + Any process that modulates the frequency, rate or extent of membrane disassembly. regulation of membrane disassembly + + + + Any process that modulates the frequency, rate or extent of membrane disassembly. + GOC:dph + GOC:tb + @@ -31928,8 +46518,16 @@ + Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. regulation of macromolecule biosynthetic process + + + + Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -31956,8 +46554,16 @@ + Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. positive regulation of macromolecule biosynthetic process + + + + Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -31984,8 +46590,16 @@ + Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. negative regulation of macromolecule biosynthetic process + + + + Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -32010,8 +46624,16 @@ + Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. regulation of glycoprotein biosynthetic process + + + + Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:dph + GOC:tb + @@ -32037,8 +46659,16 @@ + Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. positive regulation of glycoprotein biosynthetic process + + + + Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:dph + GOC:tb + @@ -32064,8 +46694,16 @@ + Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. negative regulation of glycoprotein biosynthetic process + + + + Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:dph + GOC:tb + @@ -32090,8 +46728,121 @@ + Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. regulation of cell cycle process + + + + Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + regulation of cellular ketone metabolic process + + + + + Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. + regulation of ketone biosynthetic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells. + regulation of ketone catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells. + GOC:dph + GOC:tb + @@ -32116,8 +46867,17 @@ + Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. regulation of endothelial cell migration + + + + Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. + GOC:BHF + GOC:dph + GOC:tb + @@ -32143,8 +46903,17 @@ + Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. positive regulation of endothelial cell migration + + + + Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. + GOC:BHF + GOC:dph + GOC:tb + @@ -32170,8 +46939,17 @@ + Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. negative regulation of endothelial cell migration + + + + Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. + GOC:BHF + GOC:dph + GOC:tb + @@ -32197,8 +46975,16 @@ + Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. positive regulation of macromolecule metabolic process + + + + Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -32224,8 +47010,16 @@ + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. negative regulation of macromolecule metabolic process + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -32233,8 +47027,16 @@ + Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. post-transcriptional regulation of gene expression + + + + Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. + GOC:dph + GOC:tb + @@ -32260,8 +47062,16 @@ + Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. regulation of cardiac muscle hypertrophy + + + + Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. + GOC:dph + GOC:tb + @@ -32286,8 +47096,16 @@ + Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. regulation of cardiac muscle adaptation + + + + Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. + GOC:dph + GOC:tb + @@ -32313,8 +47131,17 @@ + Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. positive regulation of cardiac muscle hypertrophy + + + + Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. + GOC:BHF + GOC:dph + GOC:tb + @@ -32340,8 +47167,17 @@ + Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. negative regulation of cardiac muscle hypertrophy + + + + Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. + GOC:BHF + GOC:dph + GOC:tb + @@ -32367,8 +47203,17 @@ + Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. positive regulation of cardiac muscle adaptation + + + + Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. + GOC:BHF + GOC:dph + GOC:tb + @@ -32394,8 +47239,17 @@ + Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. negative regulation of cardiac muscle adaptation + + + + Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. + GOC:BHF + GOC:dph + GOC:tb + @@ -32421,8 +47275,18 @@ + The activation of endogenous cellular processes that result in the death of a cell as part of its development. + This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. programmed cell death involved in cell development + + + + The activation of endogenous cellular processes that result in the death of a cell as part of its development. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32448,8 +47312,15 @@ + Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). positive regulation of gene expression + + + + Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + GOC:txnOH-2018 + @@ -32475,8 +47346,16 @@ + Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. negative regulation of gene expression + + + + Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + GOC:txnOH-2018 + @@ -32507,8 +47386,18 @@ + The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism. epithelial cell migration + + + + The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism. + GOC:BHF + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -32534,8 +47423,17 @@ + Any process that modulates the frequency, rate or extent of epithelial cell migration. regulation of epithelial cell migration + + + + Any process that modulates the frequency, rate or extent of epithelial cell migration. + GOC:BHF + GOC:dph + GOC:tb + @@ -32562,8 +47460,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. negative regulation of epithelial cell migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. + GOC:BHF + GOC:dph + GOC:tb + @@ -32589,8 +47496,17 @@ + Any process that activates or increases the frequency, rate or extent of epithelial cell migration. positive regulation of epithelial cell migration + + + + Any process that activates or increases the frequency, rate or extent of epithelial cell migration. + GOC:BHF + GOC:dph + GOC:tb + @@ -32616,8 +47532,16 @@ + Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. positive regulation of organelle organization + + + + Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + GOC:dph + GOC:tb + @@ -32643,8 +47567,16 @@ + Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. negative regulation of organelle organization + + + + Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + GOC:dph + GOC:tb + @@ -32669,8 +47601,16 @@ + Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. regulation of cell communication + + + + Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb + @@ -32696,8 +47636,16 @@ + Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. positive regulation of cell communication + + + + Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb + @@ -32723,8 +47671,16 @@ + Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. negative regulation of cell communication + + + + Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb + @@ -32750,8 +47706,17 @@ + Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. negative regulation of muscle cell apoptotic process + + + + Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32788,8 +47753,18 @@ + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. muscle cell apoptotic process + + + + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. + CL:0000187 + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32814,8 +47789,18 @@ + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations. striated muscle cell apoptotic process + + + + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations. + CL:0000737 + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32840,8 +47825,18 @@ + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. cardiac muscle cell apoptotic process + + + + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. + CL:0000746 + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32866,8 +47861,17 @@ + Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. regulation of muscle cell apoptotic process + + + + Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32893,8 +47897,17 @@ + Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. positive regulation of muscle cell apoptotic process + + + + Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32919,8 +47932,17 @@ + Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. regulation of striated muscle cell apoptotic process + + + + Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32946,8 +47968,17 @@ + Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. positive regulation of striated muscle cell apoptotic process + + + + Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32973,8 +48004,19 @@ + Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. negative regulation of striated muscle cell apoptotic process + + + + Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. + GOC:BHF + GOC:dph + GOC:mtg_apoptosis + GOC:rl + GOC:tb + @@ -32999,8 +48041,17 @@ + Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. regulation of cardiac muscle cell apoptotic process + + + + Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -33026,8 +48077,17 @@ + Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. positive regulation of cardiac muscle cell apoptotic process + + + + Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -33053,8 +48113,19 @@ + Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. negative regulation of cardiac muscle cell apoptotic process + + + + Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. + GOC:BHF + GOC:dph + GOC:mtg_apoptosis + GOC:rl + GOC:tb + @@ -33085,8 +48156,16 @@ + The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. ectodermal cell differentiation + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:dph + GOC:tb + @@ -33112,8 +48191,16 @@ + Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. negative regulation of norepinephrine secretion + + + + Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. + GOC:dph + GOC:tb + @@ -33139,8 +48226,87 @@ + Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. positive regulation of norepinephrine secretion + + + + Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + regulation of collagen catabolic process + + + + + Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + GOC:BHF + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + negative regulation of collagen catabolic process + + + + + Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + GOC:BHF + GOC:dph + GOC:tb + @@ -33165,8 +48331,16 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. regulation of collagen metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:dph + GOC:tb + @@ -33192,8 +48366,16 @@ + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. negative regulation of collagen metabolic process + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:dph + GOC:tb + @@ -33219,8 +48401,16 @@ + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. positive regulation of collagen metabolic process + + + + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:dph + GOC:tb + @@ -33245,8 +48435,17 @@ + Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. regulation of extracellular matrix disassembly + + + + Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. + GOC:BHF + GOC:dph + GOC:tb + @@ -33272,8 +48471,17 @@ + Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. negative regulation of extracellular matrix disassembly + + + + Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. + GOC:BHF + GOC:dph + GOC:tb + @@ -33298,8 +48506,17 @@ + Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. regulation of epithelial to mesenchymal transition + + + + Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. + GOC:BHF + GOC:dph + GOC:tb + @@ -33326,8 +48543,17 @@ + Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. positive regulation of epithelial to mesenchymal transition + + + + Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. + GOC:BHF + GOC:dph + GOC:tb + @@ -33354,8 +48580,17 @@ + Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. negative regulation of epithelial to mesenchymal transition + + + + Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. + GOC:BHF + GOC:dph + GOC:tb + @@ -33381,8 +48616,17 @@ + Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. positive regulation of cell development + + + + Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + GOC:BHF + GOC:dph + GOC:tb + @@ -33408,8 +48652,17 @@ + Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. negative regulation of cell development + + + + Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + GOC:BHF + GOC:dph + GOC:tb + @@ -33435,8 +48688,17 @@ + Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. regulation of macrophage chemotaxis + + + + Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. + GOC:BHF + GOC:dph + GOC:tb + @@ -33464,8 +48726,17 @@ + Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. positive regulation of macrophage chemotaxis + + + + Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. + GOC:BHF + GOC:dph + GOC:tb + @@ -33492,8 +48763,17 @@ + Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. negative regulation of macrophage chemotaxis + + + + Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. + GOC:BHF + GOC:dph + GOC:tb + @@ -33518,8 +48798,17 @@ + Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. fibroblast migration + + + + Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. + GOC:BHF + GOC:dph + GOC:tb + @@ -33544,8 +48833,16 @@ + Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. regulation of fibroblast migration + + + + Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. + GOC:dph + GOC:tb + @@ -33571,8 +48868,17 @@ + Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. positive regulation of fibroblast migration + + + + Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. + GOC:BHF + GOC:dph + GOC:tb + @@ -33598,8 +48904,16 @@ + Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. negative regulation of fibroblast migration + + + + Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. + GOC:dph + GOC:tb + @@ -33625,8 +48939,16 @@ + Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. positive regulation of cell morphogenesis + + + + Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. + GOC:dph + GOC:tb + @@ -33652,16 +48974,33 @@ + Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. negative regulation of cell morphogenesis + + + + Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. + GOC:dph + GOC:tb + + Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. regulation of hormone levels + + + + Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. + GOC:BHF + GOC:dph + GOC:tb + @@ -33681,8 +49020,16 @@ + The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. T cell chemotaxis + + + + The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. + GOC:dph + GOC:tb + @@ -33708,8 +49055,16 @@ + Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. regulation of T cell chemotaxis + + + + Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. + GOC:dph + GOC:tb + @@ -33736,8 +49091,123 @@ + Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. positive regulation of T cell chemotaxis + + + + Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. + GOC:BHF + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + regulation of glucose transmembrane transport + + + + + Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + positive regulation of glucose transmembrane transport + + + + + Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:BHF + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + negative regulation of glucose transmembrane transport + + + + + Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:BHF + GOC:dph + GOC:tb + @@ -33762,8 +49232,16 @@ + Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. regulation of myotube differentiation + + + + Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:dph + GOC:tb + @@ -33789,8 +49267,16 @@ + Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. positive regulation of myotube differentiation + + + + Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:dph + GOC:tb + @@ -33816,8 +49302,16 @@ + Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. negative regulation of myotube differentiation + + + + Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:dph + GOC:tb + @@ -33854,8 +49348,18 @@ + The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. retina layer formation + + + + The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. + GOC:ascb_2009 + GOC:dph + GOC:tb + PMID:1270266 + @@ -33880,8 +49384,157 @@ + Any process in which a lipid is transported to, or maintained in, a specific location. lipid localization + + + + Any process in which a lipid is transported to, or maintained in, a specific location. + GOC:BHF + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + positive regulation of steroid biosynthetic process + + + + + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + negative regulation of steroid biosynthetic process + + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:BHF + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + regulation of glucose metabolic process + + + + + Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + GOC:BHF + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + positive regulation of glucose metabolic process + + + + + Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + GOC:BHF + GOC:tb + @@ -33907,8 +49560,16 @@ + The cellular component assembly that is part of the initial shaping of the component during its developmental progression. cellular component assembly involved in morphogenesis + + + + The cellular component assembly that is part of the initial shaping of the component during its developmental progression. + GOC:dph + GOC:tb + @@ -33933,8 +49594,19 @@ + The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. macrophage cytokine production + + + + The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:BHF + GOC:dph + GOC:rl + GOC:tb + @@ -33959,8 +49631,16 @@ + Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. regulation of macrophage cytokine production + + + + Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:BHF + GOC:rl + @@ -33986,8 +49666,16 @@ + Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. negative regulation of macrophage cytokine production + + + + Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:BHF + GOC:rl + @@ -34013,8 +49701,16 @@ + Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization. regulation of cytoplasmic microtubule depolymerization + + + + Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization. + GOC:dph + GOC:tb + @@ -34040,8 +49736,16 @@ + The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule. cytoplasmic microtubule depolymerization + + + + The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule. + GOC:dph + GOC:tb + @@ -34067,8 +49771,50 @@ + Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. negative regulation of cell cycle process + + + + Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + regulation of glucan biosynthetic process + + + + + Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + GOC:dph + GOC:tb + @@ -34093,8 +49839,16 @@ + Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. regulation of microtubule nucleation + + + + Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. + GOC:dph + GOC:tb + @@ -34121,8 +49875,17 @@ + The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. transport along microtubule + + + + The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. + GOC:dph + GOC:mah + GOC:tb + @@ -34147,8 +49910,16 @@ + Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). regulation of neuron projection development + + + + Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). + GOC:dph + GOC:tb + @@ -34174,8 +49945,16 @@ + Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). positive regulation of neuron projection development + + + + Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). + GOC:dph + GOC:tb + @@ -34201,8 +49980,16 @@ + Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). negative regulation of neuron projection development + + + + Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). + GOC:dph + GOC:tb + @@ -34227,8 +50014,18 @@ + A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. + Wikipedia:Programmed_cell_death + Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. programmed cell death + + + + A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. + GOC:lr + GOC:mtg_apoptosis + @@ -34254,8 +50051,16 @@ + A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. + Wikipedia:Endomembrane_system endomembrane system + + + + A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. + GOC:lh + @@ -34280,8 +50085,17 @@ + The lipid bilayer surrounding any membrane-bounded vesicle in the cell. + NIF_Subcellular:sao1153182838 vesicle membrane + + + + The lipid bilayer surrounding any membrane-bounded vesicle in the cell. + GOC:mah + GOC:vesicle + @@ -34312,8 +50126,16 @@ + The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. glial cell proliferation + + + + The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. + GOC:ef + ISBN:0878932585 + @@ -34338,8 +50160,15 @@ + Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. regulation of gliogenesis + + + + Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. + GOC:ef + @@ -34365,8 +50194,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. negative regulation of gliogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. + GOC:ef + @@ -34392,8 +50228,15 @@ + Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. positive regulation of gliogenesis + + + + Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. + GOC:ef + @@ -34424,8 +50267,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. neuroblast differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. + GOC:ef + ISBN:0878932585 + @@ -34456,8 +50307,16 @@ + The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron. neuroblast development + + + + The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron. + GOC:ef + ISBN:0878932585 + @@ -34471,8 +50330,17 @@ + The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. primary neural tube formation + + + + The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. + GOC:ef + ISBN:0878932585 + PMID:15327780 + @@ -34515,8 +50383,16 @@ + The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. neural rod formation + + + + The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. + GOC:dh + GOC:ef + @@ -34547,8 +50423,16 @@ + The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts. neural keel formation + + + + The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts. + GOC:dh + GOC:ef + @@ -34585,8 +50469,16 @@ + The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. notochord formation + + + + The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. + GOC:dh + GOC:ef + @@ -34618,8 +50510,16 @@ + The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. neural crest formation + + + + The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. + GOC:dh + GOC:ef + @@ -34650,8 +50550,16 @@ + The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. mesenchymal cell development + + + + The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:dh + GOC:ef + @@ -34682,8 +50590,16 @@ + The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. neural crest cell development + + + + The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:dh + GOC:ef + @@ -34709,8 +50625,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. neural crest cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. + GOC:dh + GOC:ef + @@ -34736,8 +50660,15 @@ + Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. regulation of neuron maturation + + + + Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. + GOC:ef + @@ -34763,8 +50694,15 @@ + Any process that activates or increases the frequency, rate or extent of neuron maturation. positive regulation of neuron maturation + + + + Any process that activates or increases the frequency, rate or extent of neuron maturation. + GOC:ef + @@ -34790,8 +50728,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation. negative regulation of neuron maturation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation. + GOC:ef + @@ -34816,8 +50761,15 @@ + Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. regulation of norepinephrine secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. + GOC:ef + @@ -34843,8 +50795,15 @@ + Any process that modulates the frequency, rate or extent of the regulated release of serotonin. regulation of serotonin secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + @@ -34871,8 +50830,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. negative regulation of serotonin secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + @@ -34899,8 +50865,15 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. positive regulation of serotonin secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + @@ -34925,8 +50898,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. response to amine + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. + GOC:ef + @@ -34951,8 +50931,17 @@ + The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. striated muscle tissue development + + + + The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. + CL:0000737 + GOC:dph + GOC:mtg_muscle + @@ -34977,8 +50966,15 @@ + Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. regulation of skeletal muscle adaptation + + + + Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. + GOC:mtg_muscle + @@ -34998,8 +50994,15 @@ + The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. skeletal muscle hypertrophy + + + + The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. + GOC:mtg_muscle + @@ -35025,8 +51028,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. negative regulation of muscle hypertrophy + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. + GOC:mtg_muscle + @@ -35052,8 +51062,15 @@ + Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. positive regulation of muscle hypertrophy + + + + Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. + GOC:mtg_muscle + @@ -35078,8 +51095,15 @@ + Any process that modulates the frequency, rate or extent of muscle hypertrophy. regulation of muscle hypertrophy + + + + Any process that modulates the frequency, rate or extent of muscle hypertrophy. + GOC:mtg_muscle + @@ -35106,8 +51130,15 @@ + Any process that activates or increases the frequency, rate or extent of muscle adaptation. positive regulation of muscle adaptation + + + + Any process that activates or increases the frequency, rate or extent of muscle adaptation. + GOC:mtg_muscle + @@ -35134,8 +51165,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. negative regulation of muscle adaptation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. + GOC:mtg_muscle + @@ -35160,8 +51198,15 @@ + Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. smooth muscle adaptation + + + + Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. + GOC:mtg_muscle + @@ -35187,8 +51232,15 @@ + Any process that modulates the frequency, rate or extent of somitogenesis. regulation of somitogenesis + + + + Any process that modulates the frequency, rate or extent of somitogenesis. + GOC:mtg_muscle + @@ -35213,8 +51265,16 @@ + The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. muscle cell migration + + + + The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. + CL:0000187 + GOC:mtg_muscle + @@ -35239,8 +51299,69 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle contraction. regulation of skeletal muscle contraction + + + + Any process that modulates the frequency, rate or extent of skeletal muscle contraction. + GOC:ef + GOC:mtg_muscle + + + + + + + + + A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. + phasic smooth muscle contraction + + + + + A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. + GOC:mtg_muscle + + + + + + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. + intestine smooth muscle contraction + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. + GOC:mtg_muscle + MA:0001539 + MSH:D007422 + + + + + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract). + gastro-intestinal system smooth muscle contraction + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract). + GOC:mtg_muscle + MA:0001523 + MSH:D041981 + @@ -35265,8 +51386,17 @@ + The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. striated muscle cell proliferation + + + + The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. + CL:0000737 + GOC:ef + GOC:mtg_muscle + @@ -35291,8 +51421,17 @@ + The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. skeletal muscle cell proliferation + + + + The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. + CL:0000188 + GOC:ef + GOC:mtg_muscle + @@ -35317,8 +51456,17 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. regulation of skeletal muscle cell proliferation + + + + Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. + CL:0000188 + GOC:ef + GOC:mtg_muscle + @@ -35344,8 +51492,17 @@ + Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation. positive regulation of skeletal muscle cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation. + CL:0000188 + GOC:ef + GOC:mtg_muscle + @@ -35371,8 +51528,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation. negative regulation of skeletal muscle cell proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation. + CL:0000188 + GOC:ef + GOC:mtg_muscle + @@ -35398,8 +51564,17 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes. regulation of skeletal muscle contraction via regulation of action potential + + + + Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_muscle + @@ -35424,8 +51599,16 @@ + The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. skeletal myofibril assembly + + + + The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. + GOC:ef + GOC:mtg_muscle + @@ -35450,8 +51633,17 @@ + The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. myoblast division + + + + The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:ef + GOC:mtg_muscle + @@ -35476,8 +51668,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. response to stimulus involved in regulation of muscle adaptation + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. + GOC:ef + GOC:mtg_muscle + @@ -35502,8 +51702,15 @@ + The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. cardiac muscle adaptation + + + + The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. + GOC:mtg_muscle + @@ -35528,8 +51735,15 @@ + Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. striated muscle adaptation + + + + Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. + GOC:mtg_muscle + @@ -35549,8 +51763,15 @@ + The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy. smooth muscle hypertrophy + + + + The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy. + GOC:mtg_muscle + @@ -35564,8 +51785,16 @@ + The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. + Wikipedia:Muscle_hypertrophy muscle hypertrophy + + + + The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. + GOC:mtg_muscle + @@ -35590,8 +51819,15 @@ + The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. striated muscle hypertrophy + + + + The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. + GOC:mtg_muscle + @@ -35616,8 +51852,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. myotube differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:mtg_muscle + @@ -35648,8 +51891,15 @@ + The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. myotube cell development + + + + The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:mtg_muscle + @@ -35674,8 +51924,16 @@ + The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism. smooth muscle cell migration + + + + The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism. + CL:0000192 + GOC:mtg_muscle + @@ -35700,8 +51958,16 @@ + Any process that modulates the frequency, rate or extent of smooth muscle cell migration. regulation of smooth muscle cell migration + + + + Any process that modulates the frequency, rate or extent of smooth muscle cell migration. + CL:0000192 + GOC:mtg_muscle + @@ -35727,8 +51993,16 @@ + Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. positive regulation of smooth muscle cell migration + + + + Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. + CL:0000192 + GOC:mtg_muscle + @@ -35754,8 +52028,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. negative regulation of smooth muscle cell migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. + CL:0000192 + GOC:mtg_muscle + @@ -35775,8 +52057,327 @@ + The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. protein transport + + + + The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of an ion from one side of a membrane to the other. + monoatomic ion transmembrane transporter activity + + + + + Enables the transfer of an ion from one side of a membrane to the other. + GOC:dgf + GOC:mtg_transport + ISBN:0815340729 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. + RHEA:28695 + Reactome:R-HSA-2752067 + bicarbonate transmembrane transporter activity + + + + + Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. + GOC:ai + + + + + Reactome:R-HSA-2752067 + BESTs transport cytosolic HCO3- to extracellular region + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + Reactome:R-HSA-194079 + Reactome:R-HSA-194083 + Reactome:R-HSA-194130 + Reactome:R-HSA-5661184 + Reactome:R-HSA-5661198 + Reactome:R-HSA-9733964 + bile acid transmembrane transporter activity + + + + + Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + GOC:ai + + + + + Reactome:R-HSA-194079 + SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol + + + + + Reactome:R-HSA-194083 + SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol + + + + + Reactome:R-HSA-194130 + Transport (influx) of bile salts and acids by OATP-A + + + + + Reactome:R-HSA-5661184 + Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) + + + + + Reactome:R-HSA-5661198 + Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) + + + + + Reactome:R-HSA-9733964 + SLC51A:SLC51B transports bile salts from cytosol to extracellular region + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of carbohydrate from one side of a membrane to the other. + carbohydrate transmembrane transporter activity + + + + + Enables the transfer of carbohydrate from one side of a membrane to the other. + GOC:jl + GOC:mtg_transport + ISBN:0815340729 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. + Reactome:R-HSA-189242 + Reactome:R-HSA-5638222 + hexose transmembrane transporter activity + + + + + Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. + GOC:ai + GOC:mtg_transport + ISBN:0815340729 + + + + + Reactome:R-HSA-189242 + SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region + + + + + Reactome:R-HSA-5638222 + Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + polysaccharide transmembrane transporter activity + + + + + Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GOC:ai + GOC:mtg_transport + ISBN:0815340729 + @@ -35784,8 +52385,17 @@ + The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. actin cytoskeleton + + + + The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. + GOC:jl + ISBN:0395825172 + ISBN:0815316194 + @@ -35793,8 +52403,16 @@ + The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. microtubule cytoskeleton + + + + The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. + GOC:jl + ISBN:0395825172 + @@ -35802,8 +52420,15 @@ + The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. gas transport + + + + The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -35828,8 +52453,119 @@ + The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. oxygen transport + + + + The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + bicarbonate transport + + + + + The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:krc + + + + + + + + + + + + + + + + + + + + + + + + + + The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + monocarboxylic acid transport + + + + + The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:krc + + + + + + + + + + + + + + + + + + + + + + + + + + + + The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + bile acid and bile salt transport + + + + + The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:dph + GOC:krc + PMID:12663868 + PMID:14699511 + @@ -35860,8 +52596,15 @@ + The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. polysaccharide transport + + + + The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GOC:ai + @@ -35886,8 +52629,15 @@ + The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. peptide transport + + + + The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -35912,8 +52662,49 @@ + The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. amine transport + + + + The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + organic acid transport + + + + + The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + ISBN:0198506732 + @@ -35938,8 +52729,15 @@ + The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. organic hydroxy compound transport + + + + The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. + GOC:ai + @@ -35966,8 +52764,15 @@ + The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. protein-DNA complex transport + + + + The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -35992,8 +52797,16 @@ + The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. norepinephrine transport + + + + The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. + GOC:ai + ISBN:0198506732 + @@ -36018,8 +52831,70 @@ + The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. nucleobase-containing compound transport + + + + The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. + nucleobase-containing compound transmembrane transporter activity + + + + + Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. + GOC:ai + + + + + + + + + The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. + energy derivation by oxidation of organic compounds + + + + + The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. + GOC:mah + @@ -36028,8 +52903,53 @@ + A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. + Wikipedia:Biological_membrane + Wikipedia:Transmembrane_protein membrane + + + + A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. + GOC:dos + GOC:mah + ISBN:0815316194 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + Wikipedia:Lipid_catabolism + lipid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + GOC:go_curators + @@ -36054,8 +52974,17 @@ + A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. cellular component organization + + + + A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. + GOC:ai + GOC:jl + GOC:mah + @@ -36081,8 +53010,15 @@ + The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. cell growth + + + + The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. + GOC:ai + @@ -36107,8 +53043,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. vesicle organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. + GOC:mah + @@ -36133,8 +53076,118 @@ + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. carbohydrate biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + carbohydrate catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. + organic acid biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. + organic acid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. + ISBN:0198506732 + @@ -36159,8 +53212,17 @@ + Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. regulation of membrane potential in photoreceptor cell + + + + Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. + GOC:dph + GOC:hb + GOC:tb + @@ -36185,8 +53247,15 @@ + The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. RNA metabolic process + + + + The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. + ISBN:0198506732 + @@ -36212,8 +53281,17 @@ + A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. vesicle-mediated transport + + + + A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. + GOC:ai + GOC:mah + ISBN:08789310662000 + @@ -36239,8 +53317,15 @@ + Any process that modulates the frequency, rate or extent of striated muscle development. regulation of striated muscle tissue development + + + + Any process that modulates the frequency, rate or extent of striated muscle development. + GOC:go_curators + @@ -36265,8 +53350,15 @@ + The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. female meiosis chromosome segregation + + + + The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. + GOC:ai + @@ -36301,8 +53393,16 @@ + Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster. oocyte microtubule cytoskeleton organization + + + + Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster. + GOC:mtg_sensu + PMID:11231123 + @@ -36311,8 +53411,15 @@ + The process in which the anatomical structures of embryonic epithelia are generated and organized. morphogenesis of embryonic epithelium + + + + The process in which the anatomical structures of embryonic epithelia are generated and organized. + GOC:jl + @@ -36326,8 +53433,20 @@ + The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. + Wikipedia:Cell_migration cell migration + + + + The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. + GOC:cjm + GOC:dph + GOC:ems + GOC:pf + Wikipedia:Cell_migration + @@ -36353,8 +53472,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. negative regulation of angiogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. + GOC:go_curators + @@ -36405,8 +53531,134 @@ + The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. + Wikipedia:Sarcoplasm sarcoplasm + + + + The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. + ISBN:0198547684 + + + + + + + + + Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. + EC:3.-.-.- + Reactome:R-HSA-1236938 + Reactome:R-HSA-2029475 + Reactome:R-HSA-5694583 + Reactome:R-HSA-5695964 + Reactome:R-HSA-6786190 + Reactome:R-HSA-6788295 + Reactome:R-HSA-8938314 + Reactome:R-HSA-8952137 + hydrolase activity + + + + + Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. + ISBN:0198506732 + + + + + Reactome:R-HSA-1236938 + Partial proteolysis of antigen in phagolysosomes + + + + + Reactome:R-HSA-2029475 + Production of AA by iPLA2 upon FCGR activation + + + + + Reactome:R-HSA-5694583 + ABHD4 hydrolyses NAPE + + + + + Reactome:R-HSA-5695964 + ABHD14B hydrolyses PNPB + + + + + Reactome:R-HSA-6786190 + CMBL hydrolyses OM to OLMS + + + + + Reactome:R-HSA-6788295 + HDHD1:Mg2+ dephosphorylates PURIDP + + + + + Reactome:R-HSA-8938314 + ENPPs hydrolyse CoA-SH to PPANT, PAP + + + + + Reactome:R-HSA-8952137 + Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate + + + + + + + + + Catalysis of the hydrolysis of any ester bond. + EC:3.1.-.- + Reactome:R-HSA-162729 + Reactome:R-HSA-9023617 + Reactome:R-HSA-9023619 + Reactome:R-HSA-9749609 + hydrolase activity, acting on ester bonds + + + + + Catalysis of the hydrolysis of any ester bond. + GOC:jl + + + + + Reactome:R-HSA-162729 + uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid + + + + + Reactome:R-HSA-9023617 + Butyrylcholinesterase hydrolyzes acyl Ghrelin + + + + + Reactome:R-HSA-9023619 + Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin + + + + + Reactome:R-HSA-9749609 + BCHE hydrolyzes ASA- + @@ -36432,8 +53684,16 @@ + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. nucleologenesis + + + + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. + GOC:jl + ISBN:0198506732 + @@ -36458,8 +53718,16 @@ + The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. stem cell division + + + + The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. + GOC:jid + ISBN:0582227089 + @@ -36486,8 +53754,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. negative regulation of translation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. + GOC:isa_complete + @@ -36513,8 +53788,15 @@ + Any process that modulates the frequency, rate or extent of exocytosis. regulation of exocytosis + + + + Any process that modulates the frequency, rate or extent of exocytosis. + GOC:go_curators + @@ -36539,8 +53821,43 @@ + The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + UM-BBD_pathwayID:phe + Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. phenol-containing compound metabolic process + + + + The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + The specific behavior of an organism that is associated with reproduction. + reproductive behavior + + + + + The specific behavior of an organism that is associated with reproduction. + GOC:jl + GOC:pr + @@ -36565,8 +53882,48 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. regulation of lipid metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. + regulation of steroid metabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators + @@ -36591,8 +53948,15 @@ + Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. regulation of nucleobase-containing compound metabolic process + + + + Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:go_curators + @@ -36617,8 +53981,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. regulation of metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators + @@ -36644,8 +54015,16 @@ + The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. transmission of nerve impulse + + + + The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. + GOC:curators + ISBN:0815316194 + @@ -36676,8 +54055,17 @@ + An action potential that occurs in a neuron. neuronal action potential + + + + An action potential that occurs in a neuron. + GOC:dph + GOC:isa_complete + GOC:tb + @@ -36685,8 +54073,149 @@ + The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. + Wikipedia:Nociception sensory perception of pain + + + + The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. + GOC:curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + hexose metabolic process + + + + + The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + hexose biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + hexose catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + MetaCyc:PHENOLDEG-PWY + phenol-containing compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + ISBN:0198506732 + @@ -36711,8 +54240,50 @@ + The chemical reactions and pathways involving a protein. Includes protein modification. + Wikipedia:Protein_metabolism + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. protein metabolic process + + + + The chemical reactions and pathways involving a protein. Includes protein modification. + GOC:ma + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. + catechol-containing compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. + GOC:go_curators + @@ -36750,8 +54321,50 @@ + Any process involved in the maintenance of an internal steady state at the level of the cell. cellular homeostasis + + + + Any process involved in the maintenance of an internal steady state at the level of the cell. + GOC:isa_complete + GOC:jl + ISBN:0395825172 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). + carboxylic acid metabolic process + + + + + The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). + ISBN:0198506732 + @@ -36759,8 +54372,15 @@ + The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. outer membrane + + + + The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. + GOC:go_curators + @@ -36768,8 +54388,20 @@ + The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + Wikipedia:Antigen_presentation antigen processing and presentation + + + + The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + PMID:15771591 + PMID:15928678 + @@ -36777,8 +54409,17 @@ + A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). + Wikipedia:Sexual_reproduction + Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. sexual reproduction + + + + A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). + Wikipedia:Sexual_reproduction + @@ -36809,8 +54450,19 @@ + The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. prechordal plate formation + + + + The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -36841,8 +54493,19 @@ + The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. spinal cord development + + + + The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -36878,8 +54541,20 @@ + The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. ventral spinal cord interneuron differentiation + + + + The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:11262869 + @@ -36910,8 +54585,20 @@ + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. cell differentiation in spinal cord + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:11262869 + @@ -36942,8 +54629,19 @@ + The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. ventral spinal cord development + + + + The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -36975,8 +54673,20 @@ + The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. spinal cord motor neuron differentiation + + + + The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:11262869 + @@ -36990,8 +54700,19 @@ + The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. neural tube patterning + + + + The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -37034,8 +54755,19 @@ + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. cell differentiation in hindbrain + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -37078,8 +54810,19 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. cell proliferation in hindbrain + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -37122,8 +54865,19 @@ + The orderly movement of a cell that will reside in the hindbrain. cell migration in hindbrain + + + + The orderly movement of a cell that will reside in the hindbrain. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -37148,8 +54902,20 @@ + The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. cranial nerve development + + + + The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37180,8 +54946,20 @@ + The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. rhombomere development + + + + The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37219,8 +54997,21 @@ + The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. midbrain-hindbrain boundary initiation + + + + The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. + GOC:cls + GOC:dgh + GOC:dph + GOC:isa_complete + GOC:jid + GO_REF:0000021 + PMID:15541513 + @@ -37251,8 +55042,20 @@ + The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. pons development + + + + The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37283,8 +55086,20 @@ + The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. medulla oblongata development + + + + The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37315,8 +55130,20 @@ + The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. central nervous system morphogenesis + + + + The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0582227089 + @@ -37347,8 +55174,20 @@ + The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. midbrain-hindbrain boundary morphogenesis + + + + The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:15541513 + @@ -37379,8 +55218,20 @@ + The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. central nervous system formation + + + + The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0582227089 + @@ -37405,8 +55256,20 @@ + The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. trigeminal nerve development + + + + The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37437,8 +55300,20 @@ + The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. hindbrain morphogenesis + + + + The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37469,8 +55344,20 @@ + The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. hindbrain formation + + + + The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37507,8 +55394,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. hindbrain maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37545,8 +55444,20 @@ + The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. medulla oblongata morphogenesis + + + + The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37583,8 +55494,20 @@ + The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. medulla oblongata formation + + + + The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37621,8 +55544,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. medulla oblongata maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37659,8 +55594,20 @@ + The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. pons morphogenesis + + + + The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37697,8 +55644,20 @@ + The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. pons formation + + + + The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37735,8 +55694,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. pons maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37767,8 +55738,20 @@ + The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. rhombomere morphogenesis + + + + The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37799,8 +55782,20 @@ + The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. rhombomere formation + + + + The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37831,8 +55826,20 @@ + The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. cranial nerve morphogenesis + + + + The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37863,8 +55870,20 @@ + The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. cranial nerve formation + + + + The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37895,8 +55914,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. cranial nerve maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37927,8 +55958,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. central nervous system maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0582227089 + @@ -37959,8 +56002,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. trigeminal nerve maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37991,8 +56046,20 @@ + The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. trigeminal nerve morphogenesis + + + + The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38023,8 +56090,20 @@ + The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. trigeminal nerve formation + + + + The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38055,8 +56134,19 @@ + The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. rhombomere boundary formation + + + + The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38087,8 +56177,19 @@ + The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. nerve development + + + + The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38119,8 +56220,19 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state. nerve maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38128,8 +56240,19 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. developmental maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38160,8 +56283,20 @@ + The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. locus ceruleus development + + + + The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38198,8 +56333,20 @@ + The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. locus ceruleus morphogenesis + + + + The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38236,8 +56383,20 @@ + The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. locus ceruleus formation + + + + The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38274,8 +56433,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. locus ceruleus maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38306,8 +56477,20 @@ + The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. superior olivary nucleus development + + + + The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38344,8 +56527,20 @@ + The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. superior olivary nucleus morphogenesis + + + + The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38382,8 +56577,20 @@ + The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. superior olivary nucleus formation + + + + The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38420,8 +56627,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. superior olivary nucleus maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38452,8 +56671,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. midbrain-hindbrain boundary maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:15541513 + @@ -38484,8 +56715,20 @@ + The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure. salivary nucleus development + + + + The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure. + GOC:cls + GOC:curators + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38510,8 +56753,20 @@ + The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. superior salivary nucleus development + + + + The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. + GOC:cls + GOC:curators + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38542,8 +56797,19 @@ + The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. glial cell development + + + + The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38557,8 +56823,20 @@ + The process in which the neural tube is divided into specific regions along the rostrocaudal axis. rostrocaudal neural tube patterning + + + + The process in which the neural tube is divided into specific regions along the rostrocaudal axis. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:11262869 + @@ -38589,8 +56867,20 @@ + The process whose specific outcome is the formation of the hindbrain-spinal cord boundary. hindbrain-spinal cord boundary formation + + + + The process whose specific outcome is the formation of the hindbrain-spinal cord boundary. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:11262869 + @@ -38628,8 +56918,19 @@ + The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. neural tube development + + + + The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38660,8 +56961,19 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. central nervous system neuron differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38692,8 +57004,19 @@ + The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. central nervous system neuron development + + + + The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38724,8 +57047,22 @@ + The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. neural plate formation + + + + The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0878932437 + ISBN:0878932585 + PMID:15806586 + @@ -38734,8 +57071,19 @@ + The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate. neural plate anterior/posterior regionalization + + + + The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38749,8 +57097,21 @@ + Generation of cells within the nervous system. + Wikipedia:Neurogenesis neurogenesis + + + + Generation of cells within the nervous system. + GOC:cls + GOC:curators + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38775,8 +57136,19 @@ + The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. central nervous system vasculogenesis + + + + The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38807,8 +57179,20 @@ + The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. rhombomere cell migration + + + + The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:15629700 + @@ -38839,8 +57223,20 @@ + The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. metencephalon development + + + + The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. + GOC:cls + GOC:curators + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38865,8 +57261,16 @@ + The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. cell cycle process + + + + The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. + GOC:isa_complete + GOC:mtg_cell_cycle + @@ -38874,8 +57278,16 @@ + The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. membrane docking + + + + The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. + GOC:isa_complete + PMID:27875684 + @@ -38900,8 +57312,15 @@ + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. regulation of cell-cell adhesion + + + + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. + GOC:isa_complete + @@ -38927,8 +57346,15 @@ + Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. negative regulation of cell-cell adhesion + + + + Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. + GOC:isa_complete + @@ -38954,8 +57380,15 @@ + Any process that activates or increases the rate or extent of cell adhesion to another cell. positive regulation of cell-cell adhesion + + + + Any process that activates or increases the rate or extent of cell adhesion to another cell. + GOC:isa_complete + @@ -38981,8 +57414,16 @@ + A cellular process that results in the breakdown of a cellular component. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular component disassembly + + + + A cellular process that results in the breakdown of a cellular component. + GOC:isa_complete + @@ -38999,8 +57440,15 @@ + A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. cellular process involved in reproduction in multicellular organism + + + + A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. + GOC:isa_complete + @@ -39008,8 +57456,17 @@ + A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + Wikipedia:Reproduction reproductive process + + + + A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + GOC:dph + GOC:isa_complete + @@ -39034,8 +57491,17 @@ + A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. digestive system process + + + + A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:isa_complete + GOC:jid + GOC:mtg_cardio + @@ -39060,8 +57526,15 @@ + Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. regulation of anatomical structure morphogenesis + + + + Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. + GOC:mah + @@ -39086,8 +57559,15 @@ + Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. regulation of cell morphogenesis + + + + Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. + GOC:isa_complete + @@ -39118,8 +57598,15 @@ + The aggregation, arrangement and bonding together of a cellular component. cellular component assembly + + + + The aggregation, arrangement and bonding together of a cellular component. + GOC:isa_complete + @@ -39150,8 +57637,15 @@ + The process in which the anatomical structures of a gland are generated and organized. gland morphogenesis + + + + The process in which the anatomical structures of a gland are generated and organized. + GOC:isa_complete + @@ -39159,8 +57653,16 @@ + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. ribonucleoprotein complex biogenesis + + + + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. + GOC:isa_complete + GOC:mah + @@ -39186,8 +57688,15 @@ + A process that results in the breakdown of the extracellular matrix. extracellular matrix disassembly + + + + A process that results in the breakdown of the extracellular matrix. + GOC:jid + @@ -39219,8 +57728,175 @@ + The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. protein-RNA complex assembly + + + + The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. + Reactome:R-HSA-1236947 + Reactome:R-HSA-429036 + Reactome:R-HSA-434650 + Reactome:R-HSA-5638209 + Reactome:R-HSA-5671707 + Reactome:R-HSA-6784434 + Reactome:R-HSA-6784436 + transmembrane transporter activity + + + + + Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. + GOC:jid + GOC:mtg_transport + ISBN:0815340729 + + + + + Reactome:R-HSA-1236947 + Egress of internalized antigen to the cytosol via sec61 + + + + + Reactome:R-HSA-429036 + SLC2A9 transports Fru, Glc, urate + + + + + Reactome:R-HSA-434650 + MATEs mediate extrusion of xenobiotics + + + + + Reactome:R-HSA-5638209 + Defective SLC2A9 does not transport Fru, Glc, urate + + + + + Reactome:R-HSA-5671707 + Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA + + + + + Reactome:R-HSA-6784434 + An unknown carrier transports cytosolic glyoxylate to the peroxisome + + + + + Reactome:R-HSA-6784436 + An unknown carrier transports mitochondrial glyoxylate to the cytosol + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a macromolecule from one side of a membrane to the other. + macromolecule transmembrane transporter activity + + + + + Enables the transfer of a macromolecule from one side of a membrane to the other. + GOC:mtg_transport + ISBN:0815340729 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of transmembrane transporter activity. + regulation of transmembrane transporter activity + + + + + Any process that modulates the frequency, rate or extent of transmembrane transporter activity. + GOC:dph + GOC:mtg_cardio + GOC:mtg_transport + @@ -39245,8 +57921,15 @@ + Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. signal transduction involved in regulation of gene expression + + + + Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. + GOC:mtg_signal + @@ -39271,8 +57954,15 @@ + Any process that modulates the frequency, rate or extent of a signaling process. regulation of signaling + + + + Any process that modulates the frequency, rate or extent of a signaling process. + GOC:mtg_signal + @@ -39280,8 +57970,18 @@ + The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. + Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. signaling + + + + The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. + GOC:mtg_signal + GOC:mtg_signaling_feb11 + GOC:signaling + @@ -39307,8 +58007,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. positive regulation of signaling + + + + Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. + GOC:mtg_signal + @@ -39334,8 +58041,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. negative regulation of signaling + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. + GOC:mtg_signal + @@ -39360,8 +58074,15 @@ + The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. signal release + + + + The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. + GOC:mtg_signal + @@ -39369,8 +58090,15 @@ + The specification and formation of anisotropic intracellular organization or cell growth patterns. establishment of cell polarity + + + + The specification and formation of anisotropic intracellular organization or cell growth patterns. + GOC:mah + @@ -39395,8 +58123,16 @@ + The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. + Wikipedia:Myofibril myofibril + + + + The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. + ISBN:0815316194 + @@ -39410,8 +58146,16 @@ + The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + Wikipedia:Sarcomere sarcomere + + + + The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + ISBN:0815316194 + @@ -39436,8 +58180,15 @@ + Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. actin filament-based process + + + + Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. + GOC:mah + @@ -39462,8 +58213,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. cell projection organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. + GOC:jl + GOC:mah + PMID:16318917 + @@ -39489,8 +58249,17 @@ + Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. cell projection assembly + + + + Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. + GOC:jl + GOC:mah + PMID:18391171 + @@ -39516,8 +58285,16 @@ + Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. microvillus assembly + + + + Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. + GOC:mah + ISBN:0815316194 + @@ -39543,8 +58320,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. actin cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. + GOC:dph + GOC:jl + GOC:mah + @@ -39552,8 +58338,16 @@ + Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. actin filament-based movement + + + + Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. + GOC:BHF + GOC:mah + @@ -39578,8 +58372,15 @@ + Movement of a vesicle along an actin filament, mediated by motor proteins. vesicle transport along actin filament + + + + Movement of a vesicle along an actin filament, mediated by motor proteins. + GOC:mah + @@ -39613,8 +58414,21 @@ + A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. + Wikipedia:Cell_junction cell junction + + + + A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. + GOC:aruk + GOC:bc + GOC:mah + ISBN:0198506732 + PMID:26820516 + PMID:28096264 + @@ -39640,8 +58454,62 @@ + The regulated release of a peptide hormone from a cell. peptide hormone secretion + + + + The regulated release of a peptide hormone from a cell. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. + insulin secretion + + + + + The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. + GOC:mah + ISBN:0198506732 + @@ -39678,8 +58546,17 @@ + The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. + Wikipedia:Haematopoiesis hemopoiesis + + + + The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. + GOC:dgh + ISBN:0198506732 + @@ -39705,8 +58582,17 @@ + The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. lymphocyte differentiation + + + + The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + CL:0000542 + GOC:go_curators + @@ -39737,8 +58623,16 @@ + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. myeloid cell differentiation + + + + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. + GOC:add + ISBN:0781735149 + @@ -39764,8 +58658,15 @@ + Any process that modulates the frequency, rate or extent of endocytosis. regulation of endocytosis + + + + Any process that modulates the frequency, rate or extent of endocytosis. + GOC:go_curators + @@ -39779,8 +58680,18 @@ + Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. + NIF_Subcellular:sao885490876 + Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. transport vesicle + + + + Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. + GOC:mah + PMID:22160157 + @@ -39820,8 +58731,17 @@ + A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. + Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. secretory granule + + + + A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. + GOC:mah + ISBN:0198506732 + @@ -39846,8 +58766,16 @@ + The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. + Wikipedia:Cellular_differentiation cell differentiation + + + + The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. + ISBN:0198506732 + @@ -39872,8 +58800,50 @@ + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. regulation of cell adhesion + + + + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + Wikipedia:Protein_catabolism + This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. + protein catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + GOC:mah + @@ -39904,8 +58874,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuron. neuron differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuron. + GOC:mah + @@ -39931,8 +58908,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. extracellular matrix organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. + GOC:mah + @@ -39984,8 +58968,16 @@ + Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. collagen fibril organization + + + + Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. + GOC:mah + ISBN:0815316194 + @@ -40010,8 +59002,15 @@ + The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. glycosaminoglycan metabolic process + + + + The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. + ISBN:0192800981 + @@ -40036,8 +59035,16 @@ + The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. hyaluronan metabolic process + + + + The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. + GOC:mah + ISBN:0198506732 + @@ -40062,8 +59069,51 @@ + The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. hyaluronan biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. + GOC:mah + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. + MetaCyc:PWY-7645 + hyaluronan catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. + GOC:mah + ISBN:0198506732 + @@ -40089,8 +59139,18 @@ + The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. + Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. T cell differentiation + + + + The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. + GOC:jid + GOC:mah + GO_REF:0000022 + @@ -40121,8 +59181,16 @@ + The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. + Wikipedia:Erythropoiesis erythrocyte differentiation + + + + The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. + GOC:mah + @@ -40147,8 +59215,15 @@ + The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. megakaryocyte differentiation + + + + The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. + GOC:mah + @@ -40174,8 +59249,15 @@ + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. monocyte differentiation + + + + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. + GOC:mah + @@ -40201,8 +59283,16 @@ + The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. macrophage differentiation + + + + The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. + GOC:add + ISBN:0781735149 + @@ -40235,8 +59325,15 @@ + Formation of myofibrils, the repeating units of striated muscle. myofibril assembly + + + + Formation of myofibrils, the repeating units of striated muscle. + GOC:mah + @@ -40244,8 +59341,16 @@ + The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. chromosome condensation + + + + The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. + GOC:mah + ISBN:0815316194 + @@ -40253,8 +59358,16 @@ + Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. apoptotic nuclear changes + + + + Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. + GOC:mah + GOC:mtg_apoptosis + @@ -40268,8 +59381,16 @@ + The compaction of chromatin during apoptosis. + Wikipedia:Pyknosis apoptotic chromosome condensation + + + + The compaction of chromatin during apoptosis. + GOC:mah + @@ -40294,8 +59415,19 @@ + The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. nuclear fragmentation involved in apoptotic nuclear change + + + + The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. + GOC:dph + GOC:mah + GOC:mtg_apoptosis + GOC:tb + ISBN:0721639976 + @@ -40320,8 +59452,15 @@ + Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. regulation of ossification + + + + Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators + @@ -40347,8 +59486,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. negative regulation of ossification + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators + @@ -40375,8 +59521,15 @@ + Any process that activates or increases the frequency, rate, extent or direction of cell growth. positive regulation of cell growth + + + + Any process that activates or increases the frequency, rate, extent or direction of cell growth. + GOC:go_curators + @@ -40403,8 +59556,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. negative regulation of cell growth + + + + Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. + GOC:go_curators + @@ -40424,8 +59584,16 @@ + A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. + The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. external encapsulating structure + + + + A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. + GOC:go_curators + @@ -40450,8 +59618,18 @@ + The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. osteoclast differentiation + + + + The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. + CL:0000092 + GOC:add + ISBN:0781735149 + PMID:12161749 + @@ -40477,8 +59655,15 @@ + The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract. respiratory tube development + + + + The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract. + GOC:jid + @@ -40515,8 +59700,16 @@ + The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. lung development + + + + The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. + GOC:jid + UBERON:0002048 + @@ -40567,8 +59760,15 @@ + Any process that modulates the frequency, rate or extent of cell migration. regulation of cell migration + + + + Any process that modulates the frequency, rate or extent of cell migration. + GOC:go_curators + @@ -40594,8 +59794,15 @@ + Any process that activates or increases the frequency, rate or extent of cell migration. positive regulation of cell migration + + + + Any process that activates or increases the frequency, rate or extent of cell migration. + GOC:go_curators + @@ -40621,8 +59828,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. negative regulation of cell migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. + GOC:go_curators + @@ -40648,8 +59862,50 @@ + The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. membrane disassembly + + + + The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. + GOC:mah + + + + + + + + + + The expulsion of feces from the rectum. + Wikipedia:Defecation + defecation + + + + + The expulsion of feces from the rectum. + GOC:mah + + + + + + + + + A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. + Wikipedia:Peristalsis + peristalsis + + + + + A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. + ISBN:0198506732 + @@ -40675,8 +59931,16 @@ + The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. nuclear migration along microtubule + + + + The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. + GOC:mah + GOC:sgd_curators + @@ -40701,8 +59965,82 @@ + The contractile fiber of smooth muscle cells. smooth muscle contractile fiber + + + + The contractile fiber of smooth muscle cells. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. + bile acid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. + collagen catabolic process + + + + + The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. + GOC:mah + ISBN:0815316194 + @@ -40722,8 +60060,16 @@ + The movement of a leukocyte in response to an external stimulus. leukocyte chemotaxis + + + + The movement of a leukocyte in response to an external stimulus. + GOC:add + GOC:jl + @@ -40755,8 +60101,15 @@ + The lipid bilayer surrounding a transport vesicle. transport vesicle membrane + + + + The lipid bilayer surrounding a transport vesicle. + GOC:mah + @@ -40781,8 +60134,15 @@ + The lipid bilayer surrounding a cytoplasmic vesicle. cytoplasmic vesicle membrane + + + + The lipid bilayer surrounding a cytoplasmic vesicle. + GOC:mah + @@ -40814,8 +60174,15 @@ + The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. Golgi-associated vesicle membrane + + + + The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. + GOC:mah + @@ -40847,8 +60214,15 @@ + The lipid bilayer surrounding a secretory granule. secretory granule membrane + + + + The lipid bilayer surrounding a secretory granule. + GOC:mah + @@ -40873,8 +60247,15 @@ + The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. cytoskeleton-dependent intracellular transport + + + + The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. + GOC:mah + @@ -40917,8 +60298,16 @@ + Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber. oocyte localization involved in germarium-derived egg chamber formation + + + + Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber. + GOC:mtg_sensu + PMID:10449356 + @@ -40943,8 +60332,16 @@ + The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. granulocyte differentiation + + + + The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. + GOC:ecd + http://life.nthu.edu.tw/~g864204/dict-search1.htm + @@ -40969,8 +60366,15 @@ + Any process that modulates the frequency, rate or extent of granulocyte differentiation. regulation of granulocyte differentiation + + + + Any process that modulates the frequency, rate or extent of granulocyte differentiation. + GOC:mah + @@ -40996,8 +60400,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation. negative regulation of granulocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation. + GOC:mah + @@ -41023,8 +60434,15 @@ + Any process that activates or increases the frequency, rate or extent of granulocyte differentiation. positive regulation of granulocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of granulocyte differentiation. + GOC:mah + @@ -41055,8 +60473,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. epithelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. + GOC:ecd + PMID:11839751 + @@ -41082,8 +60508,15 @@ + Any process that modulates the frequency, rate or extent of epithelial cell differentiation. regulation of epithelial cell differentiation + + + + Any process that modulates the frequency, rate or extent of epithelial cell differentiation. + GOC:mah + @@ -41109,8 +60542,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. negative regulation of epithelial cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. + GOC:mah + @@ -41136,8 +60576,15 @@ + Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. positive regulation of epithelial cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. + GOC:mah + @@ -41162,8 +60609,15 @@ + Any process that modulates the frequency or rate of myeloid dendritic cell activation. regulation of myeloid dendritic cell activation + + + + Any process that modulates the frequency or rate of myeloid dendritic cell activation. + GOC:mah + @@ -41189,8 +60643,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation. negative regulation of myeloid dendritic cell activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation. + GOC:mah + @@ -41216,8 +60677,15 @@ + Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation. positive regulation of myeloid dendritic cell activation + + + + Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation. + GOC:mah + @@ -41248,8 +60716,16 @@ + The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). midbrain development + + + + The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). + PMID:4975589 + PMID:4992177 + @@ -41280,8 +60756,16 @@ + The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). hindbrain development + + + + The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). + PMID:4975589 + PMID:4992177 + @@ -41306,8 +60790,15 @@ + The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. notochord development + + + + The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. + GOC:dgh + @@ -41344,8 +60835,15 @@ + The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. midbrain-hindbrain boundary development + + + + The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. + GOC:dgh + @@ -41365,8 +60863,15 @@ + Any collagen trimer that passes through a lipid bilayer membrane. transmembrane collagen trimer + + + + Any collagen trimer that passes through a lipid bilayer membrane. + ISBN:0721639976 + @@ -41375,8 +60880,15 @@ + Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. establishment or maintenance of microtubule cytoskeleton polarity + + + + Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. + GOC:mah + @@ -41385,8 +60897,15 @@ + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures. establishment or maintenance of cytoskeleton polarity + + + + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures. + GOC:mah + @@ -41400,8 +60919,20 @@ + A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. + Note that we deem cilia and microtubule-based flagella to be equivalent. intraciliary transport particle + + + + A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. + GOC:cilia + GOC:kmv + PMID:14570576 + PMID:22118932 + PMID:23945166 + @@ -41411,8 +60942,152 @@ + A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. + NIF_Subcellular:nlx_subcell_20090513 + Wikipedia:Extracellular_matrix extracellular matrix + + + + A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. + GOC:BHF + GOC:mah + GOC:rph + NIF_Subcellular:nlx_subcell_20090513 + PMID:21123617 + PMID:28089324 + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones. + Wikipedia:Pancreas + pancreas development + + + + + The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones. + GOC:cvs + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. + exocrine pancreas development + + + + + The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. + GOC:cvs + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. + endocrine pancreas development + + + + + The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. + GOC:cvs + @@ -41433,8 +61108,15 @@ + The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. nuclear migration along microfilament + + + + The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. + GOC:mah + @@ -41459,8 +61141,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. + Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. actomyosin structure organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. + GOC:dph + GOC:jl + GOC:mah + @@ -41468,8 +61160,17 @@ + Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. + NIF_Subcellular:sao772007592 dense core granule + + + + Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. + NIF_Subcellular:sao772007592 + PMID:14690495 + @@ -41478,8 +61179,16 @@ + The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. embryonic camera-type eye development + + + + The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. + GOC:mah + GOC:mtg_sensu + @@ -41504,8 +61213,17 @@ + A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. + NIF_Subcellular:sao830981606 organelle membrane + + + + A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. + GOC:dos + GOC:mah + @@ -41513,8 +61231,15 @@ + Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. microtubule polymerization or depolymerization + + + + Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. + GOC:mah + @@ -41539,8 +61264,15 @@ + Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. regulation of microtubule polymerization or depolymerization + + + + Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. + GOC:mah + @@ -41566,8 +61298,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. negative regulation of microtubule polymerization or depolymerization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. + GOC:mah + @@ -41593,8 +61332,15 @@ + Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. positive regulation of microtubule polymerization or depolymerization + + + + Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. + GOC:mah + @@ -41620,8 +61366,15 @@ + Any process that modulates the frequency, rate or extent of microtubule polymerization. regulation of microtubule polymerization + + + + Any process that modulates the frequency, rate or extent of microtubule polymerization. + GOC:mah + @@ -41647,8 +61400,15 @@ + Any process that modulates the frequency, rate or extent of microtubule depolymerization. regulation of microtubule depolymerization + + + + Any process that modulates the frequency, rate or extent of microtubule depolymerization. + GOC:mah + @@ -41675,8 +61435,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. negative regulation of microtubule polymerization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. + GOC:mah + @@ -41703,8 +61470,15 @@ + Any process that activates or increases the frequency, rate or extent of microtubule polymerization. positive regulation of microtubule polymerization + + + + Any process that activates or increases the frequency, rate or extent of microtubule polymerization. + GOC:mah + @@ -41731,8 +61505,15 @@ + Any process that activates or increases the frequency, rate or extent of microtubule depolymerization. positive regulation of microtubule depolymerization + + + + Any process that activates or increases the frequency, rate or extent of microtubule depolymerization. + GOC:mah + @@ -41758,8 +61539,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. cytoplasmic microtubule organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. + GOC:mah + @@ -41810,8 +61598,18 @@ + A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). developmental induction + + + + A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). + GOC:cjm + GOC:dph + GOC:mah + PMID:24503535 + @@ -41819,8 +61617,16 @@ + A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. + Wikipedia:Pseudopod pseudopodium + + + + A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. + ISBN:0198506732 + @@ -41845,8 +61651,15 @@ + The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). neuron projection development + + + + The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). + GOC:mah + @@ -41860,8 +61673,15 @@ + The area of a motile cell closest to the direction of movement. cell leading edge + + + + The area of a motile cell closest to the direction of movement. + GOC:pg + @@ -41892,8 +61712,16 @@ + The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. cell projection membrane + + + + The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. + GOC:krc + GOC:mah + @@ -41913,8 +61741,15 @@ + The portion of the plasma membrane surrounding the leading edge of a motile cell. leading edge membrane + + + + The portion of the plasma membrane surrounding the leading edge of a motile cell. + GOC:mah + @@ -41939,8 +61774,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement. pseudopodium organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement. + GOC:pg + @@ -41966,8 +61808,18 @@ + The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane. pseudopodium assembly + + + + The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane. + GOC:dph + GOC:mah + GOC:pg + GOC:tb + @@ -41993,8 +61845,15 @@ + The myosin-based contraction and retraction of a pseudopodium. pseudopodium retraction + + + + The myosin-based contraction and retraction of a pseudopodium. + GOC:pg + @@ -42020,8 +61879,15 @@ + Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. regulation of pseudopodium assembly + + + + Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. + GOC:pg + @@ -42047,8 +61913,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia. negative regulation of pseudopodium assembly + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia. + GOC:pg + @@ -42074,8 +61947,15 @@ + Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. positive regulation of pseudopodium assembly + + + + Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. + GOC:pg + @@ -42101,8 +61981,16 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of cellular metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah + @@ -42129,8 +62017,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of cellular metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah + @@ -42157,8 +62053,16 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of cellular metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah + @@ -42184,8 +62088,16 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of cellular biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah + @@ -42212,8 +62124,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of cellular biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah + @@ -42240,8 +62160,123 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of cellular biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + regulation of cellular catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + negative regulation of cellular catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + positive regulation of cellular catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah + @@ -42267,8 +62302,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. negative regulation of protein-containing complex assembly + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. + GOC:mah + @@ -42295,8 +62337,15 @@ + Any process that activates or increases the frequency, rate or extent of protein complex assembly. positive regulation of protein-containing complex assembly + + + + Any process that activates or increases the frequency, rate or extent of protein complex assembly. + GOC:mah + @@ -42322,8 +62371,15 @@ + Any process that modulates the frequency, rate or extent of vesicle fusion. regulation of vesicle fusion + + + + Any process that modulates the frequency, rate or extent of vesicle fusion. + GOC:mah + @@ -42350,8 +62406,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. negative regulation of vesicle fusion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. + GOC:mah + @@ -42378,8 +62441,15 @@ + Any process that activates or increases the frequency, rate or extent of vesicle fusion. positive regulation of vesicle fusion + + + + Any process that activates or increases the frequency, rate or extent of vesicle fusion. + GOC:mah + @@ -42404,8 +62474,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. regulation of cell projection organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. + GOC:mah + @@ -42431,8 +62508,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. negative regulation of cell projection organization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. + GOC:mah + @@ -42458,8 +62542,15 @@ + Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. positive regulation of cell projection organization + + + + Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. + GOC:mah + @@ -42484,8 +62575,15 @@ + Any process that modulates the frequency, rate or extent of a defense response. regulation of defense response + + + + Any process that modulates the frequency, rate or extent of a defense response. + GOC:mah + @@ -42511,8 +62609,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. negative regulation of defense response + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. + GOC:mah + @@ -42538,8 +62643,15 @@ + Any process that activates or increases the frequency, rate or extent of a defense response. positive regulation of defense response + + + + Any process that activates or increases the frequency, rate or extent of a defense response. + GOC:mah + @@ -42564,8 +62676,18 @@ + A vesicle found in the cytoplasm of a cell. + NIF_Subcellular:sao180601769 cytoplasmic vesicle + + + + A vesicle found in the cytoplasm of a cell. + GOC:ai + GOC:mah + GOC:vesicles + @@ -42590,8 +62712,15 @@ + A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. protein-containing complex localization + + + + A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. + GOC:mah + @@ -42616,8 +62745,20 @@ + A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. motile cilium + + + + A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. + GOC:cilia + GOC:dgh + GOC:kmv + PMID:17009929 + PMID:20144998 + PMID:22118931 + @@ -42652,8 +62793,18 @@ + The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. + NIF_Subcellular:sao1124888485 + Wikipedia:Neuromuscular_junction + In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. neuromuscular junction + + + + The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. + GOC:nln + @@ -42678,8 +62829,17 @@ + Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. regulation of nervous system process + + + + Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. + GOC:dph + GOC:mah + GOC:tb + @@ -42705,8 +62865,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. negative regulation of nervous system process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. + GOC:dph + GOC:mah + GOC:tb + @@ -42732,8 +62901,17 @@ + Any process that activates or increases the frequency, rate or extent of a neurophysiological process. positive regulation of nervous system process + + + + Any process that activates or increases the frequency, rate or extent of a neurophysiological process. + GOC:dph + GOC:mah + GOC:tb + @@ -42758,8 +62936,17 @@ + Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. + NIF_Subcellular:sao1687101204 nuclear membrane + + + + Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. + GOC:mah + GOC:pz + @@ -42779,8 +62966,16 @@ + A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. organelle envelope + + + + A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. + GOC:mah + GOC:pz + @@ -42810,8 +63005,15 @@ + The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope. organelle outer membrane + + + + The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope. + GOC:mah + @@ -42820,8 +63022,16 @@ + The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. membrane-enclosed lumen + + + + The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. + GOC:add + GOC:mah + @@ -42835,8 +63045,16 @@ + The volume enclosed by the nuclear inner membrane. nuclear lumen + + + + The volume enclosed by the nuclear inner membrane. + GOC:mah + GOC:pz + @@ -42844,8 +63062,87 @@ + Any small, fluid-filled, spherical organelle enclosed by membrane. + NIF_Subcellular:sao221389602 + Wikipedia:Vesicle_(biology) vesicle + + + + Any small, fluid-filled, spherical organelle enclosed by membrane. + GOC:mah + GOC:pz + GOC:vesicles + + + + + + + + + + + + + + + + + + + + + + + + + + Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + locomotion involved in locomotory behavior + + + + + Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. + positive regulation of insulin secretion + + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. + GOC:mah + @@ -42874,8 +63171,15 @@ + Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. negative regulation of translational initiation in response to stress + + + + Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. + GOC:mah + @@ -42904,8 +63208,15 @@ + Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress. positive regulation of translational initiation in response to stress + + + + Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress. + GOC:mah + @@ -42913,8 +63224,19 @@ + A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. + Wikipedia:Bleb_(cell_biology) bleb + + + + A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. + GOC:mtg_apoptosis + PMID:12083798 + PMID:16624291 + Wikipedia:Bleb_(cell_biology) + @@ -42939,8 +63261,227 @@ + The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. bleb assembly + + + + The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. + GOC:mah + GOC:mtg_apoptosis + PMID:12083798 + PMID:16624291 + Wikipedia:Bleb_(cell_biology) + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + regulation of nuclease activity + + + + + Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + regulation of deoxyribonuclease activity + + + + + Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + negative regulation of nuclease activity + + + + + Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + positive regulation of nuclease activity + + + + + Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + negative regulation of deoxyribonuclease activity + + + + + Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + positive regulation of deoxyribonuclease activity + + + + + Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + GOC:mah + @@ -42965,8 +63506,16 @@ + Any process that modulates the frequency, rate or extent of a response to an external stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of response to external stimulus + + + + Any process that modulates the frequency, rate or extent of a response to an external stimulus. + GOC:mah + @@ -42992,8 +63541,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of response to external stimulus + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. + GOC:mah + @@ -43019,8 +63576,16 @@ + Any process that activates, maintains or increases the rate of a response to an external stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of response to external stimulus + + + + Any process that activates, maintains or increases the rate of a response to an external stimulus. + GOC:mah + @@ -43051,8 +63616,15 @@ + The lipid bilayer surrounding a dense core granule. dense core granule membrane + + + + The lipid bilayer surrounding a dense core granule. + GOC:mah + @@ -43078,8 +63650,15 @@ + Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. regulation of actin filament bundle assembly + + + + Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. + GOC:mah + @@ -43106,8 +63685,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. negative regulation of actin filament bundle assembly + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. + GOC:mah + @@ -43135,8 +63721,15 @@ + Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. positive regulation of actin filament bundle assembly + + + + Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. + GOC:mah + @@ -43161,8 +63754,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of nucleobase-containing compound transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43188,8 +63788,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of nucleobase-containing compound transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43215,8 +63822,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of nucleobase-containing compound transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43241,8 +63855,15 @@ + Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. secretory granule localization + + + + Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. + GOC:mah + @@ -43267,8 +63888,15 @@ + Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell. dense core granule localization + + + + Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell. + GOC:mah + @@ -43293,8 +63921,15 @@ + Any process that modulates the frequency, rate or extent of the process of creating protein polymers. regulation of protein polymerization + + + + Any process that modulates the frequency, rate or extent of the process of creating protein polymers. + GOC:mah + @@ -43320,8 +63955,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. negative regulation of protein polymerization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. + GOC:mah + @@ -43347,8 +63989,15 @@ + Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. positive regulation of protein polymerization + + + + Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. + GOC:mah + @@ -43374,8 +64023,15 @@ + Any process that modulates the frequency, rate or extent of chondrocyte differentiation. regulation of chondrocyte differentiation + + + + Any process that modulates the frequency, rate or extent of chondrocyte differentiation. + GOC:mah + @@ -43402,8 +64058,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. negative regulation of chondrocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. + GOC:mah + @@ -43430,8 +64093,48 @@ + Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. positive regulation of chondrocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell. + intracellular oxygen homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell. + GOC:rph + @@ -43455,8 +64158,15 @@ + The directed movement of lipids within cells. intracellular lipid transport + + + + The directed movement of lipids within cells. + GOC:mah + @@ -43482,8 +64192,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of lipid transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43510,8 +64227,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of lipid transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43538,8 +64262,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of lipid transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43565,8 +64296,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. regulation of intracellular lipid transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. + GOC:mah + @@ -43593,8 +64331,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells. negative regulation of intracellular lipid transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells. + GOC:mah + @@ -43621,8 +64366,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells. positive regulation of intracellular lipid transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells. + GOC:mah + @@ -43648,8 +64400,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. regulation of intracellular transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. + GOC:mah + @@ -43676,8 +64435,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. negative regulation of intracellular transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. + GOC:mah + @@ -43704,8 +64470,224 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. positive regulation of intracellular transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the activity of a transporter. + regulation of transporter activity + + + + + Any process that modulates the activity of a transporter. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the activity of a transporter. + negative regulation of transporter activity + + + + + Any process that stops or reduces the activity of a transporter. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the activity of a transporter. + positive regulation of transporter activity + + + + + Any process that activates or increases the activity of a transporter. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the activity of an ion transporter. + regulation of monoatomic ion transmembrane transporter activity + + + + + Any process that modulates the activity of an ion transporter. + GOC:mah + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the activity of an ion transporter. + negative regulation of ion transmembrane transporter activity + + + + + Any process that stops or reduces the activity of an ion transporter. + GOC:mah + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the activity of an ion transporter. + positive regulation of ion transmembrane transporter activity + + + + + Any process that activates or increases the activity of an ion transporter. + GOC:mah + GOC:tb + @@ -43730,8 +64712,15 @@ + Any process in which a lysosome is transported to, and/or maintained in, a specific location. lysosome localization + + + + Any process in which a lysosome is transported to, and/or maintained in, a specific location. + GOC:mah + @@ -43751,8 +64740,15 @@ + An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. actin filament bundle + + + + An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. + GOC:mah + @@ -43864,8 +64860,19 @@ + Any biological process, occurring at the level of a multicellular organism, pertinent to its function. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. multicellular organismal process + + + + Any biological process, occurring at the level of a multicellular organism, pertinent to its function. + GOC:curators + GOC:dph + GOC:isa_complete + GOC:tb + @@ -43873,8 +64880,15 @@ + A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. developmental process + + + + A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. + GOC:isa_complete + @@ -43925,8 +64939,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. microvillus organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. + GOC:mah + @@ -43951,8 +64972,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. regulation of microvillus organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. + GOC:mah + @@ -43978,8 +65006,15 @@ + A process that modulates the formation of a microvillus. regulation of microvillus assembly + + + + A process that modulates the formation of a microvillus. + GOC:mah + @@ -44011,8 +65046,15 @@ + The portion of the plasma membrane surrounding a neuron projection. neuron projection membrane + + + + The portion of the plasma membrane surrounding a neuron projection. + GOC:mah + @@ -44038,8 +65080,15 @@ + The directed movement of a protein from one location to another within a lipid bilayer. protein transport within lipid bilayer + + + + The directed movement of a protein from one location to another within a lipid bilayer. + GOC:mah + @@ -44064,8 +65113,83 @@ + The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. + Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. RNA biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. + GOC:mah + GOC:txnOH + + + + + + + + + + + + + + + + + + + + + + + + + + The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. + bile acid secretion + + + + + The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. + GOC:ecd + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). + monocarboxylic acid metabolic process + + + + + The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). + GOC:vk + @@ -44090,8 +65214,16 @@ + The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. ribosome disassembly + + + + The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. + GOC:mah + GOC:vk + @@ -44116,8 +65248,80 @@ + All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. plasma membrane bounded cell projection cytoplasm + + + + All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. + GOC:krc + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. + response to insulin + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. + GOC:mah + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. + cellular response to insulin stimulus + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. + GOC:mah + ISBN:0198506732 + @@ -44142,8 +65346,15 @@ + Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion. regulation of karyogamy + + + + Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion. + GOC:mah + @@ -44168,8 +65379,15 @@ + Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. regulation of establishment or maintenance of cell polarity + + + + Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. + GOC:mah + @@ -44194,8 +65412,15 @@ + Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. regulation of localization + + + + Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. + GOC:mah + @@ -44220,8 +65445,17 @@ + Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. regulation of protein localization + + + + Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. + GOC:dph + GOC:mah + GOC:tb + @@ -44247,8 +65481,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. regulation of polysaccharide metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. + GOC:mah + @@ -44275,8 +65516,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. regulation of polysaccharide biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. + GOC:mah + @@ -44301,8 +65549,116 @@ + Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. regulation of microtubule-based process + + + + Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + regulation of organic acid transport + + + + + Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + negative regulation of organic acid transport + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + positive regulation of organic acid transport + + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -44311,8 +65667,33 @@ + The controlled release of a substance by a cell. + Wikipedia:Secretion secretion by cell + + + + The controlled release of a substance by a cell. + GOC:mah + + + + + + + + + + The controlled release of a substance by a tissue. + secretion by tissue + + + + + The controlled release of a substance by a tissue. + GOC:mah + @@ -44337,8 +65718,15 @@ + The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. mononuclear cell proliferation + + + + The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. + GOC:add + @@ -44363,8 +65751,15 @@ + Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. regulation of mononuclear cell proliferation + + + + Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. + GOC:add + @@ -44390,8 +65785,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. negative regulation of mononuclear cell proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. + GOC:add + @@ -44417,8 +65819,15 @@ + Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. positive regulation of mononuclear cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. + GOC:add + @@ -44444,8 +65853,15 @@ + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. regulation of actin cytoskeleton organization + + + + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. + GOC:mah + @@ -44470,8 +65886,16 @@ + The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). collagen metabolic process + + + + The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). + GOC:mah + ISBN:0198506732 + @@ -44496,8 +65920,16 @@ + The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). collagen biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). + GOC:mah + ISBN:0198506732 + @@ -44522,8 +65954,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. regulation of collagen biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:mah + @@ -44549,8 +65988,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. negative regulation of collagen biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:mah + @@ -44576,8 +66022,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. positive regulation of collagen biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:mah + @@ -44602,8 +66055,15 @@ + Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. regulation of actin filament-based process + + + + Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. + GOC:mah + @@ -44629,8 +66089,15 @@ + The disaggregation of a protein-containing macromolecular complex into its constituent components. protein-containing complex disassembly + + + + The disaggregation of a protein-containing macromolecular complex into its constituent components. + GOC:mah + @@ -44656,8 +66123,15 @@ + The disaggregation of a protein-DNA complex into its constituent components. protein-DNA complex disassembly + + + + The disaggregation of a protein-DNA complex into its constituent components. + GOC:mah + @@ -44683,8 +66157,15 @@ + The disaggregation of a protein-RNA complex into its constituent components. protein-RNA complex disassembly + + + + The disaggregation of a protein-RNA complex into its constituent components. + GOC:mah + @@ -44692,8 +66173,17 @@ + The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system. cellular anatomical entity morphogenesis + + + + The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system. + GOC:dph + GOC:mah + GOC:tb + @@ -44708,8 +66198,17 @@ + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. + A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. protein-containing complex + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. + GOC:dos + GOC:mah + @@ -44723,8 +66222,16 @@ + A macromolecular complex containing both protein and DNA molecules. + Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. protein-DNA complex + + + + A macromolecular complex containing both protein and DNA molecules. + GOC:mah + @@ -44732,8 +66239,16 @@ + A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin. Fc receptor complex + + + + A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin. + GOC:add + ISBN:0781735149 + @@ -44741,8 +66256,18 @@ + A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG. Fc-gamma receptor III complex + + + + A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG. + GOC:add + ISBN:0781735149 + PMID:11244038 + PMID:12413532 + @@ -44767,8 +66292,16 @@ + The expansion of a muscle cell population by cell division. muscle cell proliferation + + + + The expansion of a muscle cell population by cell division. + CL:0000187 + GOC:mah + @@ -44793,8 +66326,20 @@ + Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. myeloid cell apoptotic process + + + + Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. + CL:0000763 + GOC:add + GOC:mtg_apoptosis + PMID:11292031 + PMID:15330259 + PMID:17133093 + @@ -44819,8 +66364,16 @@ + Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. regulation of myeloid cell apoptotic process + + + + Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. + GOC:add + GOC:mtg_apoptosis + @@ -44846,8 +66399,16 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. negative regulation of myeloid cell apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. + GOC:add + GOC:mtg_apoptosis + @@ -44873,8 +66434,16 @@ + Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process. positive regulation of myeloid cell apoptotic process + + + + Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process. + GOC:add + GOC:mtg_apoptosis + @@ -44882,8 +66451,15 @@ + Any process in which a macromolecule is transported to, or maintained in, a specific location. macromolecule localization + + + + Any process in which a macromolecule is transported to, or maintained in, a specific location. + GOC:mah + @@ -44908,8 +66484,15 @@ + Any process in which a polysaccharide is transported to, or maintained in, a specific location. polysaccharide localization + + + + Any process in which a polysaccharide is transported to, or maintained in, a specific location. + GOC:mah + @@ -44934,8 +66517,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. regulation of organelle organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + GOC:mah + @@ -44960,8 +66550,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. regulation of chromosome organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. + GOC:mah + @@ -44987,8 +66584,15 @@ + Any process that modulates the frequency, rate or extent of sister chromatid segregation. regulation of sister chromatid segregation + + + + Any process that modulates the frequency, rate or extent of sister chromatid segregation. + GOC:mah + @@ -45015,8 +66619,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation. negative regulation of sister chromatid segregation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation. + GOC:mah + @@ -45041,8 +66652,15 @@ + Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis. regulation of mitotic sister chromatid segregation + + + + Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis. + GOC:mah + @@ -45068,8 +66686,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis. negative regulation of mitotic sister chromatid segregation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis. + GOC:mah + @@ -45078,8 +66703,15 @@ + The deposition or aggregation of coloring matter in a cell. cellular pigmentation + + + + The deposition or aggregation of coloring matter in a cell. + GOC:mtg_MIT_16mar07 + @@ -45105,8 +66737,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. regulation of intracellular protein transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. + GOC:mah + @@ -45131,8 +66770,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. regulation of amine metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. + GOC:mah + @@ -45158,8 +66804,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. negative regulation of amine metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. + GOC:mah + @@ -45185,8 +66838,116 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. positive regulation of amine metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + regulation of amine catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + negative regulation of amine catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + positive regulation of amine catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + GOC:mah + @@ -45217,8 +66978,16 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. cell proliferation in midbrain + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. + GOC:dgf + GO_REF:0000021 + @@ -45249,8 +67018,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. secretory granule organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. + GOC:mah + @@ -45275,8 +67051,15 @@ + A process in which a protein is transported to, or maintained in, a location within an organelle. protein localization to organelle + + + + A process in which a protein is transported to, or maintained in, a location within an organelle. + GOC:mah + @@ -45301,8 +67084,15 @@ + A process in which a protein is transported to, or maintained in, a location within a secretory granule. protein localization to secretory granule + + + + A process in which a protein is transported to, or maintained in, a location within a secretory granule. + GOC:mah + @@ -45331,8 +67121,48 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. T cell secretory granule organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. + carbohydrate homeostasis + + + + + A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. + GOC:mah + @@ -45359,8 +67189,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. negative regulation of catecholamine secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. + GOC:mah + @@ -45387,8 +67224,15 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. positive regulation of catecholamine secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. + GOC:mah + @@ -45413,8 +67257,15 @@ + A process in which a ribosome is transported to, and/or maintained in, a specific location. ribosome localization + + + + A process in which a ribosome is transported to, and/or maintained in, a specific location. + GOC:mah + @@ -45439,8 +67290,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. response to glucagon + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. + GOC:sl + @@ -45465,8 +67323,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. response to lipid + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. + GOC:sl + @@ -45491,8 +67356,15 @@ + A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. protein localization to Golgi apparatus + + + + A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. + GOC:mah + @@ -45517,8 +67389,17 @@ + Any process of regulating the production and elimination of erythrocytes within an organism. erythrocyte homeostasis + + + + Any process of regulating the production and elimination of erythrocytes within an organism. + GOC:add + PMID:10694114 + PMID:14754397 + @@ -45543,8 +67424,15 @@ + Any process that modulates the frequency, rate, or extent of tissue remodeling. regulation of tissue remodeling + + + + Any process that modulates the frequency, rate, or extent of tissue remodeling. + GOC:add + @@ -45570,8 +67458,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. negative regulation of tissue remodeling + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. + GOC:add + @@ -45597,8 +67492,15 @@ + Any process that activates or increases the frequency, rate, or extent of tissue remodeling. positive regulation of tissue remodeling + + + + Any process that activates or increases the frequency, rate, or extent of tissue remodeling. + GOC:add + @@ -45622,8 +67524,16 @@ + The process in which a carbohydrate is transported across a membrane. + Note that this term is not intended for use in annotating lateral movement within membranes. carbohydrate transmembrane transport + + + + The process in which a carbohydrate is transported across a membrane. + GOC:mah + @@ -45647,8 +67557,16 @@ + A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + Note that this term is not intended for use in annotating lateral movement within membranes. monoatomic ion transmembrane transport + + + + A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + GOC:mah + @@ -45675,8 +67593,15 @@ + Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. negative regulation of syncytium formation by plasma membrane fusion + + + + Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. + GOC:mah + @@ -45701,8 +67626,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. regulation of amide metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. + GOC:mah + @@ -45728,8 +67660,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. negative regulation of amide metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. + GOC:mah + @@ -45755,8 +67694,116 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. positive regulation of amide metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + regulation of amide catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + negative regulation of amide catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + positive regulation of amide catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + GOC:mah + @@ -45781,8 +67828,15 @@ + A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. cell junction assembly + + + + A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. + GOC:mah + @@ -45807,8 +67861,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. cell junction organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. + GOC:dph + GOC:jl + GOC:mah + @@ -45833,8 +67896,17 @@ + Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system. glial cell apoptotic process + + + + Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system. + CL:0000125 + GOC:mtg_apoptosis + GOC:sart + @@ -45859,8 +67931,16 @@ + Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. regulation of glial cell apoptotic process + + + + Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. + GOC:mah + GOC:mtg_apoptosis + @@ -45886,8 +67966,16 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process. negative regulation of glial cell apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process. + GOC:mah + GOC:mtg_apoptosis + @@ -45913,8 +68001,16 @@ + Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process. positive regulation of glial cell apoptotic process + + + + Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process. + GOC:mah + GOC:mtg_apoptosis + @@ -45939,8 +68035,19 @@ + Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. smooth muscle cell apoptotic process + + + + Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. + CL:0000192 + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + GOC:rl + @@ -45965,8 +68072,17 @@ + Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. regulation of smooth muscle cell apoptotic process + + + + Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + GOC:rl + @@ -45992,8 +68108,17 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. negative regulation of smooth muscle cell apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + GOC:rl + @@ -46019,8 +68144,17 @@ + Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process. positive regulation of smooth muscle cell apoptotic process + + + + Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + GOC:rl + @@ -46045,8 +68179,17 @@ + The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. glycoprotein transport + + + + The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:BHF + GOC:mah + GOC:rl + @@ -46075,8 +68218,16 @@ + The process in which a solute is transported from one side of the vacuolar membrane to the other. + Note that this term is not intended for use in annotating lateral movement within membranes. vacuolar transmembrane transport + + + + The process in which a solute is transported from one side of the vacuolar membrane to the other. + GOC:mah + @@ -46101,8 +68252,15 @@ + Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. protein localization to chromosome + + + + Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. + GOC:mah + @@ -46127,8 +68285,15 @@ + A process in which a protein transports or maintains the localization of another protein to the nucleus. protein localization to nucleus + + + + A process in which a protein transports or maintains the localization of another protein to the nucleus. + GOC:ecd + @@ -46153,8 +68318,48 @@ + The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. nucleobase-containing compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. + nucleobase-containing compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:mah + @@ -46180,8 +68385,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. regulation of transmembrane transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. + GOC:mah + @@ -46208,8 +68420,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. negative regulation of transmembrane transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. + GOC:mah + @@ -46236,8 +68455,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. positive regulation of transmembrane transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. + GOC:mah + @@ -46263,8 +68489,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. regulation of monoatomic ion transmembrane transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. + GOC:mah + @@ -46291,8 +68524,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. negative regulation of monoatomic ion transmembrane transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. + GOC:mah + @@ -46319,8 +68559,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. positive regulation of monoatomic ion transmembrane transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. + GOC:mah + @@ -46345,8 +68592,17 @@ + The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion. + Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer. basement membrane disassembly + + + + The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion. + GOC:sart + PMID:17301221 + @@ -46384,8 +68640,15 @@ + The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. embryonic heart tube development + + + + The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. + GOC:go_curators + @@ -46416,8 +68679,15 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. cardiocyte differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. + GOC:bf + @@ -46449,8 +68719,19 @@ + The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. + Note that cilia and eukaryotic flagella are deemed to be equivalent. axoneme assembly + + + + The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. + GOC:bf + GOC:cilia + GOC:jl + ISBN:0815316194 + @@ -46481,8 +68762,15 @@ + The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. appendage morphogenesis + + + + The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. + ISBN:0582227089 + @@ -46514,8 +68802,15 @@ + The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. genitalia morphogenesis + + + + The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. + GOC:bf + @@ -46546,8 +68841,15 @@ + Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. tube formation + + + + Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. + GOC:bf + @@ -46578,8 +68880,17 @@ + The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex. syncytial nuclear migration + + + + The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex. + GOC:bf + ISBN:0879694238 + PMID:8314839 + @@ -46605,8 +68916,15 @@ + Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. ectopic germ cell programmed cell death + + + + Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. + PMID:12814944 + @@ -46637,8 +68955,16 @@ + The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. tube morphogenesis + + + + The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + GOC:bf + PMID:14624839 + @@ -46663,8 +68989,16 @@ + The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. internal genitalia morphogenesis + + + + The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. + PMID:24793987 + PMID:25247640 + @@ -46689,8 +69023,16 @@ + The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. external genitalia morphogenesis + + + + The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. + PMID:24793987 + PMID:25247640 + @@ -46722,8 +69064,15 @@ + The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals. gonad morphogenesis + + + + The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals. + ISBN:0198612001 + @@ -46749,8 +69098,18 @@ + The increase in size or mass of an entire multicellular organism, as opposed to cell growth. multicellular organism growth + + + + The increase in size or mass of an entire multicellular organism, as opposed to cell growth. + GOC:bf + GOC:curators + GOC:dph + GOC:tb + @@ -46776,8 +69135,17 @@ + The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. organ growth + + + + The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. + GOC:bf + ISBN:0471245208 + ISBN:0721662544 + @@ -46802,8 +69170,16 @@ + Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. endocrine system development + + + + Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. + GOC:bf + Wikipedia:Development_of_the_endocrine_system + @@ -46828,8 +69204,16 @@ + Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. exocrine system development + + + + Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. + GOC:bf + Wikipedia:Exocrine_gland + @@ -46837,8 +69221,17 @@ + The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. + Wikipedia:Segmentation_(biology) segmentation + + + + The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. + PMID:10611687 + PMID:9706689 + @@ -46852,8 +69245,15 @@ + Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. trunk segmentation + + + + Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. + PMID:1360402 + @@ -46884,8 +69284,15 @@ + The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. tube development + + + + The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. + PMID:12526790 + @@ -46910,8 +69317,16 @@ + A process in which a protein is transported to, or maintained at, a microtubule. protein localization to microtubule + + + + A process in which a protein is transported to, or maintained at, a microtubule. + GOC:bf + GOC:lb + @@ -46936,8 +69351,15 @@ + Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. protein localization to synapse + + + + Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. + GOC:bf + @@ -46962,8 +69384,15 @@ + The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes. cell migration involved in vasculogenesis + + + + The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes. + GOC:dgh + @@ -46988,8 +69417,18 @@ + The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. intracellular signal transduction + + + + The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. + GOC:bf + GOC:jl + GOC:signaling + ISBN:3527303782 + @@ -47021,8 +69460,16 @@ + The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. azurophil granule membrane + + + + The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. + GOC:bf + PMID:17152095 + @@ -47042,8 +69489,129 @@ + The directed movement of a protein to a specific location within the extracellular region. establishment of protein localization to extracellular region + + + + The directed movement of a protein to a specific location within the extracellular region. + GOC:BHF + GOC:bf + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). + intrahepatic bile duct development + + + + + The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). + GOC:bf + PMID:20614624 + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct. + cystic duct development + + + + + The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct. + PMID:20614624 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine. + enteric smooth muscle cell differentiation + + + + + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine. + CL:0002504 + GOC:BHF + @@ -47068,8 +69636,17 @@ + The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. hematopoietic stem cell migration + + + + The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. + CL:0000037 + GOC:BHF + PMID:20234092 + @@ -47095,8 +69672,17 @@ + The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. monocyte homeostasis + + + + The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. + CL:0000576 + GOC:BHF + PMID:18832716 + @@ -47121,8 +69707,16 @@ + The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly. intraciliary transport involved in cilium assembly + + + + The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly. + GOC:bf + GOC:cilia + @@ -47147,8 +69741,16 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis. cell proliferation involved in compound eye morphogenesis + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis. + GOC:bf + GOC:sart + @@ -47168,8 +69770,86 @@ + The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). endothelial cell chemotaxis + + + + The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). + CL:0000115 + GOC:BHF + + + + + + + + + + + + + + + + + + + + + + + + + + The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus. + insulin secretion involved in cellular response to glucose stimulus + + + + + The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus. + GOC:bf + GOC:yaf + PMID:8492079 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + positive regulation of insulin secretion involved in cellular response to glucose stimulus + + + + + Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + GOC:bf + GOC:yaf + @@ -47200,8 +69880,16 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells). angioblast cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells). + CL:0000566 + GOC:yaf + @@ -47238,8 +69926,62 @@ + A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. egg coat + + + + A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. + PMID:16944418 + PMID:17163408 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates. + cloaca development + + + + + The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates. + GOC:dgh + ISBN:0582227089 + @@ -47270,8 +70012,17 @@ + The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. megakaryocyte development + + + + The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. + CL:0000556 + GOC:BHF + GOC:vk + @@ -47285,8 +70036,18 @@ + A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. + Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone. ciliary transition zone + + + + A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. + GOC:cilia + GOC:kmv + PMID:21422230 + @@ -47311,8 +70072,16 @@ + The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. enteroendocrine cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. + CL:0000164 + GOC:bf + @@ -47343,8 +70112,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. vascular associated smooth muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. + GOC:sl + PMID:16151017 + PMID:18267954 + @@ -47369,8 +70147,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta. aortic smooth muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta. + GOC:sl + @@ -47395,8 +70180,19 @@ + The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. aorta development + + + + The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. + GOC:bf + GOC:dgh + MA:0000062 + UBERON:0000947 + Wikipedia:Aorta + @@ -47427,8 +70223,19 @@ + The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. ascending aorta development + + + + The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. + GOC:bf + GOC:dgh + MA:0002570 + UBERON:0001496 + Wikipedia:Ascending_aorta + @@ -47459,8 +70266,19 @@ + The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. descending aorta development + + + + The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. + GOC:bf + GOC:dgh + MA:0002571 + UBERON:0001514 + Wikipedia:Descending_aorta + @@ -47485,8 +70303,19 @@ + The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. dorsal aorta development + + + + The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. + GOC:bf + GOC:dgh + UBERON:0005805 + Wikipedia:Aorta + ZFA:0000014 + @@ -47517,8 +70346,19 @@ + The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. aorta morphogenesis + + + + The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. + GOC:bf + GOC:dgh + MA:0000062 + UBERON:0000947 + Wikipedia:Aorta + @@ -47555,8 +70395,19 @@ + The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. ascending aorta morphogenesis + + + + The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. + GOC:bf + GOC:dgh + MA:0002570 + UBERON:0001496 + Wikipedia:Ascending_aorta + @@ -47593,8 +70444,19 @@ + The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. descending aorta morphogenesis + + + + The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. + GOC:bf + GOC:dgh + MA:0002571 + UBERON:0001514 + Wikipedia:Descending_aorta + @@ -47625,8 +70487,19 @@ + The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. dorsal aorta morphogenesis + + + + The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. + GOC:bf + GOC:dgh + UBERON:0005805 + Wikipedia:Aorta + ZFA:0000014 + @@ -47657,8 +70530,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. skeletal muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. + CL:0000188 + GOC:BHF + GOC:vk + @@ -47684,8 +70566,15 @@ + The regulated release of any steroid that acts as a hormone into the circulatory system. steroid hormone secretion + + + + The regulated release of any steroid that acts as a hormone into the circulatory system. + GOC:sl + @@ -47693,8 +70582,15 @@ + The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates. androgen secretion + + + + The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates. + GOC:sl + @@ -47725,8 +70621,17 @@ + The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. endodermal cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. + CL:0000223 + GOC:yaf + PMID:17624332 + @@ -47751,8 +70656,17 @@ + The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. tendon development + + + + The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. + GOC:yaf + PMID:21412429 + UBERON:0000043 + @@ -47783,8 +70697,17 @@ + The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts. tendon formation + + + + The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts. + GOC:yaf + PMID:17567668 + UBERON:0000043 + @@ -47816,8 +70739,17 @@ + The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. osteoclast development + + + + The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. + CL:0000092 + GOC:bf + GOC:yaf + @@ -47825,8 +70757,15 @@ + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. direct ossification + + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. + GO_REF:0000034 + @@ -47857,8 +70796,16 @@ + The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. germ cell proliferation + + + + The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. + CL:0000586 + GOC:kmv + @@ -47883,8 +70830,18 @@ + The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. dendritic cell homeostasis + + + + The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. + CL:0000451 + GOC:uh + PMID:12570827 + PMID:19176316 + @@ -47915,8 +70872,16 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes. osteoclast maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes. + CL:0000092 + GOC:pg + @@ -47941,8 +70906,18 @@ + A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. muscle cell projection + + + + A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. + CL:0000187 + GOC:kmv + PMID:15930100 + PMID:22464329 + @@ -47967,8 +70942,18 @@ + The portion of the plasma membrane surrounding a muscle cell projection. muscle cell projection membrane + + + + The portion of the plasma membrane surrounding a muscle cell projection. + CL:0000187 + GOC:kmv + PMID:15930100 + PMID:22464329 + @@ -47993,8 +70978,16 @@ + The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. granulocyte activation + + + + The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + CL:0000094 + GOC:nhn + @@ -48002,8 +70995,51 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. + This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. response to decreased oxygen levels + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. + GOC:al + + + + + + + + + + + + + + + + + + + + + + + + + + Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules. + hepatocyte homeostasis + + + + + Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules. + CL:0000182 + GOC:nhn + PMID:19878874 + @@ -48028,8 +71064,17 @@ + Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells. epidermal stem cell homeostasis + + + + Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells. + CL:1000428 + GOC:nhn + PMID:17666529 + @@ -48054,8 +71099,64 @@ + The movement of a dendritic cell within or between different tissues and organs of the body. dendritic cell migration + + + + The movement of a dendritic cell within or between different tissues and organs of the body. + CL:0000451 + GOC:nhn + PMID:19339990 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. + post-anal tail morphogenesis + + + + + The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. + GOC:bf + GOC:kmv + Wikipedia:Chordate + @@ -48069,8 +71170,16 @@ + The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. somatodendritic compartment + + + + The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. + GOC:PARL + GOC:pad + @@ -48101,8 +71210,18 @@ + The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo. trunk neural crest cell migration + + + + The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo. + GOC:PARL + GOC:bf + GOC:mat + PMID:2387238 + @@ -48133,8 +71252,17 @@ + The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane. Golgi membrane fusion + + + + The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane. + GOC:PARL + GOC:bf + PMID:12473691 + @@ -48154,8 +71282,17 @@ + The increase in size or mass of an entire organism, a part of an organism or a cell. + See also the biological process term 'cell growth ; GO:0016049'. growth + + + + The increase in size or mass of an entire organism, a part of an organism or a cell. + GOC:bf + GOC:ma + @@ -48180,8 +71317,16 @@ + Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. regulation of growth + + + + Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. + GOC:ems + GOC:mah + @@ -48215,8 +71360,15 @@ + Self-propelled movement of a cell or organism from one location to another. locomotion + + + + Self-propelled movement of a cell or organism from one location to another. + GOC:dgh + @@ -48241,8 +71393,15 @@ + Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. regulation of locomotion + + + + Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. + GOC:ems + @@ -48268,8 +71427,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. negative regulation of locomotion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. + GOC:go_curators + @@ -48295,8 +71461,17 @@ + Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. regulation of multicellular organism growth + + + + Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. + GOC:dph + GOC:ems + GOC:tb + @@ -48323,8 +71498,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. negative regulation of multicellular organism growth + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. + GOC:dph + GOC:ems + GOC:tb + @@ -48338,8 +71522,16 @@ + The first few specialized divisions of an activated animal egg. embryonic cleavage + + + + The first few specialized divisions of an activated animal egg. + GOC:clt + ISBN:0070524300 + @@ -48365,8 +71557,15 @@ + Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. positive regulation of locomotion + + + + Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. + GOC:go_curators + @@ -48393,8 +71592,17 @@ + Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. positive regulation of multicellular organism growth + + + + Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. + GOC:dph + GOC:go_curators + GOC:tb + @@ -48421,8 +71629,15 @@ + Any process that activates or increases the frequency, rate or extent of embryonic development. positive regulation of embryonic development + + + + Any process that activates or increases the frequency, rate or extent of embryonic development. + GOC:go_curators + @@ -48449,8 +71664,16 @@ + Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. regulation of meiotic nuclear division + + + + Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. + GOC:ems + GOC:ma + @@ -48458,8 +71681,15 @@ + Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. regulation of development, heterochronic + + + + Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. + PMID:9442909 + @@ -48484,8 +71714,16 @@ + The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. gliogenesis + + + + The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. + GOC:dgh + GOC:jid + @@ -48516,8 +71754,17 @@ + Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. glial cell growth + + + + Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. + GOC:dph + GOC:isa_complete + GOC:jid + @@ -48543,8 +71790,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. regulation of catecholamine metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. + GOC:go_curators + @@ -48752,8 +72006,21 @@ + The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. + Wikipedia:Intraflagellar_transport + Note that we deem cilium and microtubule-based flagellum to be equivalent. intraciliary transport + + + + The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. + GOC:cilia + GOC:kmv + PMID:17981739 + PMID:18180368 + PMID:22869374 + @@ -48778,8 +72045,16 @@ + The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). cell migration involved in gastrulation + + + + The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). + GOC:jl + PMID:16099638 + @@ -48810,8 +72085,16 @@ + The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. germ-line stem cell division + + + + The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. + GOC:jid + PMID:2279698 + @@ -48837,8 +72120,15 @@ + The expansion of a T cell population by cell division. Follows T cell activation. T cell proliferation + + + + The expansion of a T cell population by cell division. Follows T cell activation. + GOC:jl + @@ -48865,8 +72155,15 @@ + Any process that activates or increases the rate or extent of T cell proliferation. positive regulation of T cell proliferation + + + + Any process that activates or increases the rate or extent of T cell proliferation. + GOC:ai + @@ -48892,8 +72189,15 @@ + Any process that activates or increases the rate or extent of resting T cell proliferation. positive regulation of T cell homeostatic proliferation + + + + Any process that activates or increases the rate or extent of resting T cell proliferation. + GOC:jl + @@ -48918,8 +72222,16 @@ + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. T cell activation + + + + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. + GOC:mgi_curators + ISBN:0781735149 + @@ -48944,8 +72256,17 @@ + A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. macrophage activation + + + + A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + GOC:mgi_curators + ISBN:0781735149 + PMID:14506301 + @@ -48970,8 +72291,16 @@ + The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. monocyte activation + + + + The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + GOC:mgi_curators + ISBN:0781735149 + @@ -48996,8 +72325,18 @@ + The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. endothelial cell activation + + + + The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + GOC:mgi_curators + ISBN:0781735149 + PMID:12851652 + PMID:14581484 + @@ -49048,8 +72387,15 @@ + Any process that modulates the frequency, rate or extent of cell proliferation. regulation of cell population proliferation + + + + Any process that modulates the frequency, rate or extent of cell proliferation. + GOC:jl + @@ -49075,8 +72421,15 @@ + Any process that modulates the frequency, rate or extent of T cell proliferation. regulation of T cell proliferation + + + + Any process that modulates the frequency, rate or extent of T cell proliferation. + GOC:jl + @@ -49103,8 +72456,15 @@ + Any process that stops, prevents or reduces the rate or extent of T cell proliferation. negative regulation of T cell proliferation + + + + Any process that stops, prevents or reduces the rate or extent of T cell proliferation. + GOC:jl + @@ -49129,8 +72489,15 @@ + The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. lipoprotein metabolic process + + + + The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. + ISBN:0198506732 + @@ -49155,8 +72522,48 @@ + The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. lipoprotein biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. + lipoprotein catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. + ISBN:0198506732 + @@ -49170,8 +72577,196 @@ + The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. nuclear outer membrane-endoplasmic reticulum membrane network + + + + The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. + GOC:bf + GOC:jl + GOC:mah + GOC:mcc + GOC:pr + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + regulation of protein catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + GOC:go_curators + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. + negative regulation of protein catabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. + GOC:TermGenie + GOC:kmv + GOC:obol + GO_REF:0000058 + PMID:24785082 + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + cellular ketone metabolic process + + + + + The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:jl + ISBN:0787650153 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + ketone biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + ketone catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:go_curators + @@ -49196,8 +72791,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to chemical + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + GOC:jl + @@ -49205,8 +72808,17 @@ + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. ribosome biogenesis + + + + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. + GOC:ma + PMID:26404467 + Wikipedia:Ribosome_biogenesis + @@ -49237,8 +72849,16 @@ + The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. ribosome assembly + + + + The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. + GOC:ma + PMID:30467428 + @@ -49252,8 +72872,17 @@ + The directed movement of a motile cell or organism in response to an external stimulus. + Wikipedia:Taxis taxis + + + + The directed movement of a motile cell or organism in response to an external stimulus. + GOC:jl + ISBN:0192801023 + @@ -49266,8 +72895,18 @@ + Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. regulation of membrane potential + + + + Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. + GOC:jl + GOC:mtg_cardio + GOC:tb + ISBN:0198506732 + @@ -49276,8 +72915,34 @@ + The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. biogenic amine biosynthetic process + + + + The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. + GOC:jl + ISBN:0395825172 + + + + + + + + + The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. + cellular biogenic amine catabolic process + + + + + The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. + GOC:go_curators + GOC:jl + ISBN:0198506732 + @@ -49302,8 +72967,16 @@ + The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. norepinephrine metabolic process + + + + The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. + GOC:jl + ISBN:0198506732 + @@ -49328,8 +73001,51 @@ + The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. norepinephrine biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. + Wikipedia:Norepinephrine#Degradation + norepinephrine catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. + GOC:jl + ISBN:0198506732 + @@ -49354,8 +73070,51 @@ + The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + Wikipedia:Catecholamines catecholamine biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + catecholamine catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:jl + ISBN:0198506732 + @@ -49380,8 +73139,17 @@ + The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + Wikipedia:Serotonin serotonin biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + GOC:jl + ISBN:0198506732 + @@ -49409,8 +73177,50 @@ + The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. serotonin metabolic process + + + + The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + serotonin catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + GOC:jl + ISBN:0198506732 + @@ -49435,8 +73245,16 @@ + The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. indole-containing compound metabolic process + + + + The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. + GOC:jl + GOC:mah + @@ -49462,8 +73280,48 @@ + The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. indole-containing compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. + indole-containing compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. + GOC:jl + @@ -49494,8 +73352,15 @@ + Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. photoreceptor cell development + + + + Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. + GOC:go_curators + @@ -49526,8 +73391,16 @@ + Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. eye photoreceptor cell development + + + + Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. + GOC:jl + ISBN:0192800981 + @@ -49553,8 +73426,15 @@ + Any process that modulates the frequency, rate or extent of eye photoreceptor development. regulation of eye photoreceptor cell development + + + + Any process that modulates the frequency, rate or extent of eye photoreceptor development. + GOC:jl + @@ -49581,8 +73461,15 @@ + Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. positive regulation of eye photoreceptor cell development + + + + Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. + GOC:jl + @@ -49608,8 +73495,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development. negative regulation of eye photoreceptor cell development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development. + GOC:jl + @@ -49640,8 +73534,16 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. neuron maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. + GOC:dph + GOC:jl + @@ -49650,8 +73552,75 @@ + Primary lysosomal granule readily stainable with a Romanowsky stain. azurophil granule + + + + Primary lysosomal granule readily stainable with a Romanowsky stain. + GOC:jl + PMID:17152095 + PMID:28717070 + PMID:5914694 + WIKIPEDIA:Azurophilic_granule + + + + + + + + + A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. + zymogen granule + + + + + A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The lipid bilayer surrounding a zymogen granule. + zymogen granule membrane + + + + + The lipid bilayer surrounding a zymogen granule. + GOC:jl + @@ -49659,8 +73628,49 @@ + Any biological process involved in the maintenance of an internal steady state. homeostatic process + + + + Any biological process involved in the maintenance of an internal steady state. + GOC:jl + ISBN:0395825172 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. + glucose homeostasis + + + + + Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. + GOC:go_curators + @@ -49668,8 +73678,19 @@ + A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. MHC protein complex + + + + A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. + GOC:add + GOC:jl + ISBN:0781735149 + PMID:15928678 + PMID:16153240 + @@ -49677,8 +73698,18 @@ + A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. MHC class II protein complex + + + + A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. + GOC:add + GOC:jl + ISBN:0120781859 + PMID:15928678 + @@ -49692,8 +73723,15 @@ + Any complex of actin, myosin, and accessory proteins. actomyosin + + + + Any complex of actin, myosin, and accessory proteins. + GOC:go_curators + @@ -49718,8 +73756,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. retinal cone cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. + GOC:go_curators + @@ -49750,8 +73795,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. + CL:0000187 + GOC:go_curators + @@ -49771,8 +73824,15 @@ + Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. defense response to bacterium + + + + Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. + GOC:jl + @@ -49797,8 +73857,56 @@ + The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. amide transport + + + + The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. + amide transmembrane transporter activity + + + + + Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. + GOC:jl + ISBN:0198506732 + @@ -49818,8 +73926,16 @@ + The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. lipoprotein transport + + + + The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + ISBN:0198506732 + @@ -49870,8 +73986,17 @@ + Any process that modulates the occurrence or rate of cell death by apoptotic process. + This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. regulation of apoptotic process + + + + Any process that modulates the occurrence or rate of cell death by apoptotic process. + GOC:jl + GOC:mtg_apoptosis + @@ -49885,8 +74010,16 @@ + A prolongation or process extending from a cell, e.g. a flagellum or axon. cell projection + + + + A prolongation or process extending from a cell, e.g. a flagellum or axon. + GOC:jl + PMID:16318917 + @@ -49913,8 +74046,15 @@ + Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. regulation of Golgi to plasma membrane protein transport + + + + Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. + GOC:jl + @@ -49941,8 +74081,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. negative regulation of Golgi to plasma membrane protein transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. + GOC:jl + @@ -49969,8 +74116,15 @@ + Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. positive regulation of Golgi to plasma membrane protein transport + + + + Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. + GOC:jl + @@ -49999,8 +74153,15 @@ + The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. Golgi to plasma membrane protein transport + + + + The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. + ISBN:0716731363 + @@ -50051,8 +74212,17 @@ + A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. + NIF_Subcellular:sao867568886 neuron projection + + + + A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. + GOC:jl + PMID:3077060 + @@ -50072,8 +74242,15 @@ + The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. chordate embryonic development + + + + The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. + GOC:mtg_sensu + @@ -50124,8 +74301,16 @@ + The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. camera-type eye development + + + + The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. + GOC:go_curators + GOC:mtg_sensu + @@ -50152,8 +74337,17 @@ + The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. + Wikipedia:Dendritic_cell myeloid dendritic cell differentiation + + + + The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. + CL:0000782 + GOC:jl + @@ -50178,8 +74372,18 @@ + The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. + NIF_Subcellular:sao1044911821 + Wikipedia:Soma_(biology) + Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. neuronal cell body + + + + The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. + GOC:go_curators + @@ -50204,8 +74408,17 @@ + The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. + Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus. T cell homeostasis + + + + The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. + GOC:mgi_curators + ISBN:0781735149 + @@ -50230,8 +74443,15 @@ + Any process that modulates the frequency or rate of macrophage activation. regulation of macrophage activation + + + + Any process that modulates the frequency or rate of macrophage activation. + GOC:jl + @@ -50257,8 +74477,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation. negative regulation of macrophage activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation. + GOC:jl + @@ -50284,8 +74511,15 @@ + Any process that stimulates, induces or increases the rate of macrophage activation. positive regulation of macrophage activation + + + + Any process that stimulates, induces or increases the rate of macrophage activation. + GOC:jl + @@ -50310,8 +74544,16 @@ + The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. peptide biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. + GOC:dph + GOC:jl + @@ -50336,8 +74578,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. extracellular structure organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. + GOC:ai + GOC:dph + GOC:jl + GOC:mah + @@ -50363,8 +74615,17 @@ + Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. + This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. positive regulation of apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. + GOC:jl + GOC:mtg_apoptosis + @@ -50396,8 +74657,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. + This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. negative regulation of apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. + GOC:jl + GOC:mtg_apoptosis + @@ -50422,8 +74692,15 @@ + Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. regulation of programmed cell death + + + + Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. + GOC:jl + @@ -50449,8 +74726,15 @@ + Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. positive regulation of programmed cell death + + + + Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. + GOC:jl + @@ -50476,8 +74760,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. negative regulation of programmed cell death + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. + GOC:jl + @@ -50502,8 +74793,90 @@ + The nucleus of a germ cell, a reproductive cell in multicellular organisms. germ cell nucleus + + + + The nucleus of a germ cell, a reproductive cell in multicellular organisms. + CL:0000586 + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the activity of an enzyme. + positive regulation of catalytic activity + + + + + Any process that activates or increases the activity of an enzyme. + GOC:ebc + GOC:jl + GOC:tb + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the activity of an enzyme. + negative regulation of catalytic activity + + + + + Any process that stops or reduces the activity of an enzyme. + GOC:ebc + GOC:jl + GOC:tb + GOC:vw + @@ -50511,8 +74884,87 @@ + Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid. surfactant homeostasis + + + + Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid. + PMID:23708874 + PMID:9751757 + + + + + + + + + + + + + + + + + + + + + + + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine. + hindgut contraction + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine. + GOC:jl + GOC:mtg_muscle + UBERON:0001046 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + regulation of hindgut contraction + + + + + Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + GOC:jl + UBERON:0001046 + @@ -50538,8 +74990,15 @@ + Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location. regulation of translation by machinery localization + + + + Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location. + GOC:jl + @@ -50564,8 +75023,48 @@ + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. macromolecule metabolic process + + + + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. + peptide catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. + GOC:jl + @@ -50574,8 +75073,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. response to external biotic stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. + GOC:go_curators + @@ -50583,8 +75089,17 @@ + Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. + NIF_Subcellular:sao1539965131 + Wikipedia:Organelle organelle + + + + Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. + GOC:go_curators + @@ -50610,8 +75125,16 @@ + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + NIF_Subcellular:sao414196390 membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + GOC:go_curators + @@ -50619,8 +75142,16 @@ + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. + NIF_Subcellular:sao1456184038 non-membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. + GOC:go_curators + @@ -50646,8 +75177,15 @@ + Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. intracellular organelle + + + + Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + GOC:go_curators + @@ -50672,8 +75210,16 @@ + Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. extracellular organelle + + + + Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. + GOC:jl + PMID:9914479 + @@ -50693,8 +75239,15 @@ + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. intracellular membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + GOC:go_curators + @@ -50714,8 +75267,15 @@ + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. intracellular non-membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. + GOC:go_curators + @@ -50740,8 +75300,16 @@ + The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. organelle lumen + + + + The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. + GOC:jl + GOC:mah + @@ -50767,8 +75335,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. negative regulation of protein-containing complex disassembly + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. + GOC:jl + @@ -50794,8 +75369,15 @@ + Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. positive regulation of protein-containing complex disassembly + + + + Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. + GOC:jl + @@ -50820,8 +75402,15 @@ + Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. regulation of protein-containing complex disassembly + + + + Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. + GOC:jl + @@ -50852,8 +75441,16 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. erythrocyte maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. + GOC:devbiol + GOC:jl + @@ -50879,8 +75476,15 @@ + Any process that modulates the frequency, rate or extent of protein complex assembly. regulation of protein-containing complex assembly + + + + Any process that modulates the frequency, rate or extent of protein complex assembly. + GOC:jl + @@ -50906,8 +75510,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. regulation of carbohydrate biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. + GOC:jl + @@ -50927,8 +75538,15 @@ + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. extracellular non-membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. + GOC:jl + @@ -50953,8 +75571,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of monoatomic ion transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + @@ -50980,8 +75605,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of monoatomic ion transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + @@ -51007,8 +75639,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of monoatomic ion transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + @@ -51041,8 +75680,16 @@ + Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. contractile muscle fiber + + + + Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. + GOC:go_curators + ISBN:0815316194 + @@ -51073,8 +75720,16 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus. nucleate erythrocyte maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus. + GOC:devbiol + GOC:jl + @@ -51099,8 +75754,15 @@ + The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. nucleate erythrocyte differentiation + + + + The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. + GOC:jl + @@ -51125,8 +75787,116 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. response to peptide hormone + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. + PMID:11027914 + PMID:15134857 + Wikipedia:Peptide_hormone + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). + oxoacid metabolic process + + + + + The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). + Wikipedia:Oxyacid + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. + regulation of generation of precursor metabolites and energy + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. + regulation of carbohydrate catabolic process + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. + GOC:mlg + @@ -51146,8 +75916,15 @@ + The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. pigmentation + + + + The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. + GOC:jl + @@ -51162,8 +75939,18 @@ + A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. muscle adaptation + + + + A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. + GOC:mtg_muscle + PMID:11181628 + PMID:11449884 + PMID:12605307 + @@ -51188,8 +75975,18 @@ + Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. skeletal muscle adaptation + + + + Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. + GOC:mtg_muscle + PMID:11181628 + PMID:11449884 + PMID:12605307 + @@ -51215,8 +76012,16 @@ + Any process that modulates the frequency, rate or extent of muscle adaptation. regulation of muscle adaptation + + + + Any process that modulates the frequency, rate or extent of muscle adaptation. + GOC:go_curators + GOC:mtg_muscle + @@ -51241,8 +76046,16 @@ + Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. regulation of neuron apoptotic process + + + + Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. + GOC:go_curators + GOC:mtg_apoptosis + @@ -51268,8 +76081,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. negative regulation of neuron apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. + GOC:go_curators + GOC:mtg_apoptosis + @@ -51295,8 +76116,16 @@ + Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. positive regulation of neuron apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. + GOC:go_curators + GOC:mtg_apoptosis + @@ -51321,8 +76150,15 @@ + The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. blood vessel endothelial cell migration + + + + The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. + PMID:11166264 + @@ -51347,8 +76183,15 @@ + Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. regulation of blood vessel endothelial cell migration + + + + Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. + GOC:go_curators + @@ -51374,8 +76217,15 @@ + Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. positive regulation of blood vessel endothelial cell migration + + + + Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. + GOC:go_curators + @@ -51401,8 +76251,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. negative regulation of blood vessel endothelial cell migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. + GOC:go_curators + @@ -51427,8 +76284,15 @@ + The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. endothelial cell migration + + + + The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. + GOC:go_curators + @@ -51453,8 +76317,15 @@ + Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. regulation of respiratory gaseous exchange + + + + Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. + GOC:jl + @@ -51531,8 +76402,16 @@ + The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. skin development + + + + The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. + GOC:jl + UBERON:0002097 + @@ -51563,8 +76442,16 @@ + The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. skin morphogenesis + + + + The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. + GOC:jl + UBERON:0002097 + @@ -51589,8 +76476,16 @@ + The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. amide metabolic process + + + + The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. + GOC:curators + @@ -51616,8 +76511,48 @@ + The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. amide biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. + GOC:curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. + amide catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. + GOC:curators + @@ -51642,8 +76577,17 @@ + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state. ossification involved in bone maturation + + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state. + GOC:dph + GOC:mah + GOC:mtg_mpo + @@ -51668,8 +76612,16 @@ + The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli. ossification involved in bone remodeling + + + + The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli. + GOC:mtg_mpo + GO_REF:0000034 + @@ -51694,8 +76646,48 @@ + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. protein-containing complex organization + + + + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. + glucan metabolic process + + + + + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. + GOC:jl + @@ -51720,8 +76712,15 @@ + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. regulation of system process + + + + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. + GOC:jl + @@ -51746,8 +76745,15 @@ + Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. regulation of digestive system process + + + + Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:jl + @@ -51772,8 +76778,49 @@ + Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. regulation of endocrine process + + + + Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. + regulation of excretion + + + + + Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. + GOC:jl + @@ -51799,8 +76846,15 @@ + Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. regulation of respiratory system process + + + + Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. + GOC:jl + @@ -51808,8 +76862,16 @@ + A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. cellular component biogenesis + + + + A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. + GOC:jl + GOC:mah + @@ -51834,8 +76896,15 @@ + Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. regulation of cellular component biogenesis + + + + Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. + GOC:jl + @@ -51860,8 +76929,16 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. regulation of vacuole organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. + GOC:jl + GOC:mah + @@ -51887,8 +76964,15 @@ + Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. positive regulation of cellular component biogenesis + + + + Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. + GOC:jl + @@ -51914,8 +76998,16 @@ + Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. positive regulation of vacuole organization + + + + Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. + GOC:jl + GOC:mah + @@ -51940,8 +77032,81 @@ + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. membrane biogenesis + + + + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + negative regulation of molecular function + + + + + Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GO:jl + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + positive regulation of molecular function + + + + + Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GO:jl + @@ -51955,8 +77120,15 @@ + A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). translation initiation ternary complex + + + + A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). + GOC:jl + @@ -51965,8 +77137,16 @@ + The chemical reactions and pathways by which individual cells transform chemical substances. + This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. cellular metabolic process + + + + The chemical reactions and pathways by which individual cells transform chemical substances. + GOC:go_curators + @@ -51974,8 +77154,33 @@ + The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + Wikipedia:Primary_metabolite primary metabolic process + + + + The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + GOC:go_curators + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + cellular catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:jl + @@ -51984,8 +77189,108 @@ + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. cellular biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas. + intestinal lipid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas. + GOC:jl + PMID:7018485 + + + + + + + + + The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. + Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. + small molecule metabolic process + + + + + The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. + GOC:curators + GOC:pde + GOC:vw + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. + Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. + small molecule catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. + GOC:curators + GOC:vw + + + + + + + + + + The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. + Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. + small molecule biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. + GOC:curators + GOC:pde + GOC:vw + @@ -52025,8 +77330,53 @@ + The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. + FBbt:00005107 + FMA:67301 + Wikipedia:Cell_body + Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. cell body + + + + The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. + type B pancreatic cell proliferation + + + + + The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. + GOC:jl + GOC:yaf + @@ -52051,8 +77401,18 @@ + Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. fibroblast apoptotic process + + + + Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. + CL:0000057 + GOC:jl + GOC:mtg_apoptosis + GOC:yaf + @@ -52077,8 +77437,15 @@ + A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. protein localization to cytoskeleton + + + + A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. + GOC:jl + @@ -52112,8 +77479,15 @@ + Any process evolved to enable an interaction with an organism of a different species. biological process involved in interspecies interaction between organisms + + + + Any process evolved to enable an interaction with an organism of a different species. + GOC:cc + @@ -52138,8 +77512,21 @@ + The aggregation, arrangement and bonding together of a set of components to form a motile cilium. motile cilium assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a motile cilium. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000079 + PMID:19776033 + PMID:21129373 + ZFIN:dsf + @@ -52164,8 +77551,16 @@ + The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. dendritic cell proliferation + + + + The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. + CL:0000451 + PMID:18469816 + @@ -52190,8 +77585,16 @@ + A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage. chondrocyte activation + + + + A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage. + CL:0000138 + GOC:jl + @@ -52199,8 +77602,15 @@ + A biological process that directly contributes to the process of producing new individuals, involving another organism. multi-organism reproductive process + + + + A biological process that directly contributes to the process of producing new individuals, involving another organism. + GOC:jl + @@ -52208,8 +77618,15 @@ + A multicellular organism process which involves another multicellular organism of the same or different species. multi-multicellular organism process + + + + A multicellular organism process which involves another multicellular organism of the same or different species. + GOC:jl + @@ -52247,8 +77664,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + Note that we deem cilium and microtubule-based flagellum to be equivalent. cilium organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + GOC:cilia + GOC:jl + @@ -52273,8 +77699,15 @@ + Any process in which a lipoprotein is transported to, or maintained in, a specific location. lipoprotein localization + + + + Any process in which a lipoprotein is transported to, or maintained in, a specific location. + GOC:jl + @@ -52294,8 +77727,15 @@ + A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane. lipoprotein localization to membrane + + + + A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane. + GOC:jl + @@ -52320,8 +77760,15 @@ + A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. lipoprotein localization to outer membrane + + + + A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. + GOC:jl + @@ -52347,8 +77794,16 @@ + The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. plasma membrane fusion + + + + The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. + GOC:elh + GOC:mtg_muscle + @@ -52373,8 +77828,15 @@ + Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). regulation of bone resorption + + + + Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). + GOC:ai + @@ -52400,8 +77862,16 @@ + The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. meiotic chromosome segregation + + + + The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. + GOC:ai + GOC:mah + @@ -52421,8 +77891,15 @@ + The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. development of primary sexual characteristics + + + + The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. + GOC:ai + @@ -52436,8 +77913,16 @@ + The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. + Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. cell fate commitment + + + + The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. + ISBN:0716731185 + @@ -52462,8 +77947,17 @@ + Signaling at long or short range between cells that results in the commitment of a cell to a certain fate. cell-cell signaling involved in cell fate commitment + + + + Signaling at long or short range between cells that results in the commitment of a cell to a certain fate. + GOC:dph + GOC:go_curators + GOC:tb + @@ -52489,8 +77983,15 @@ + The directed movement of a protein to a specific location. establishment of protein localization + + + + The directed movement of a protein to a specific location. + GOC:bf + @@ -52504,8 +78005,19 @@ + Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. establishment or maintenance of neuroblast polarity + + + + Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. + GOC:bf + GOC:mah + GOC:mtg_sensu + PMID:19375318 + PMID:20066083 + @@ -52531,8 +78043,16 @@ + The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. establishment of neuroblast polarity + + + + The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. + GOC:bf + GOC:mtg_sensu + @@ -52552,8 +78072,21 @@ + The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. + NIF_Subcellular:sao914572699 + Wikipedia:Chemical_synapse synapse + + + + The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. + GOC:aruk + ISBN:0198506732 + PMID:24619342 + PMID:29383328 + PMID:31998110 + @@ -52584,8 +78117,15 @@ + The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. sarcomere organization + + + + The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + GOC:bf + @@ -52610,8 +78150,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. cell-cell junction organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. + GOC:ai + GOC:dph + GOC:jl + GOC:mah + @@ -52636,8 +78186,16 @@ + The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions. CD4 biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions. + GOC:go_curators + ISBN:0198506732 + @@ -52662,8 +78220,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. regulation of CD4 production + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. + GOC:go_curators + @@ -52689,8 +78254,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. positive regulation of CD4 production + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. + GOC:go_curators + @@ -52716,8 +78288,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. negative regulation of CD4 production + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. + GOC:go_curators + @@ -52742,8 +78321,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. external encapsulating structure organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. + GOC:ai + GOC:dph + GOC:jl + GOC:mah + @@ -52781,8 +78370,16 @@ + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. + Wikipedia:Immunologic_activation leukocyte activation + + + + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. + GOC:add + @@ -52807,8 +78404,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. fat cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. + CL:0000136 + GOC:go_curators + @@ -52839,8 +78444,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. myoblast differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. + CL:0000056 + GOC:go_curators + GOC:mtg_muscle + @@ -52871,8 +78485,16 @@ + The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. endothelial cell differentiation + + + + The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. + CL:0000115 + GOC:go_curators + @@ -52886,8 +78508,17 @@ + The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. + Wikipedia:Bone_resorption bone resorption + + + + The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. + GOC:mah + PMID:10968780 + @@ -52913,8 +78544,16 @@ + Any process that modulates the frequency, rate or extent of T cell differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. regulation of T cell differentiation + + + + Any process that modulates the frequency, rate or extent of T cell differentiation. + GOC:go_curators + @@ -52941,8 +78580,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. negative regulation of T cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. + GOC:go_curators + @@ -52969,8 +78616,16 @@ + Any process that activates or increases the frequency, rate or extent of T cell differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. positive regulation of T cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of T cell differentiation. + GOC:go_curators + @@ -52996,8 +78651,15 @@ + Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. regulation of cell differentiation + + + + Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. + GOC:go_curators + @@ -53024,8 +78686,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. negative regulation of cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. + GOC:go_curators + @@ -53052,8 +78721,15 @@ + Any process that activates or increases the frequency, rate or extent of cell differentiation. positive regulation of cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of cell differentiation. + GOC:go_curators + @@ -53078,8 +78754,15 @@ + Any process that modulates the frequency, rate or extent of adipocyte differentiation. regulation of fat cell differentiation + + + + Any process that modulates the frequency, rate or extent of adipocyte differentiation. + GOC:go_curators + @@ -53105,8 +78788,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. negative regulation of fat cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. + GOC:go_curators + @@ -53132,8 +78822,15 @@ + Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. positive regulation of fat cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. + GOC:go_curators + @@ -53158,8 +78855,15 @@ + Any process that modulates the frequency, rate or extent of endothelial cell differentiation. regulation of endothelial cell differentiation + + + + Any process that modulates the frequency, rate or extent of endothelial cell differentiation. + GOC:go_curators + @@ -53185,8 +78889,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. negative regulation of endothelial cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. + GOC:go_curators + @@ -53212,8 +78923,15 @@ + Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. positive regulation of endothelial cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. + GOC:go_curators + @@ -53239,8 +78957,15 @@ + Any process that modulates the frequency, rate or extent of epidermal cell differentiation. regulation of epidermal cell differentiation + + + + Any process that modulates the frequency, rate or extent of epidermal cell differentiation. + GOC:go_curators + @@ -53267,8 +78992,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. negative regulation of epidermal cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. + GOC:go_curators + @@ -53295,8 +79027,15 @@ + Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. positive regulation of epidermal cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. + GOC:go_curators + @@ -53322,8 +79061,16 @@ + Any process that modulates the frequency, rate or extent of lymphocyte differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. regulation of lymphocyte differentiation + + + + Any process that modulates the frequency, rate or extent of lymphocyte differentiation. + GOC:go_curators + @@ -53350,8 +79097,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. negative regulation of lymphocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. + GOC:go_curators + @@ -53378,8 +79133,16 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. positive regulation of lymphocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. + GOC:go_curators + @@ -53404,8 +79167,15 @@ + Any process that modulates the frequency, rate or extent of myeloid cell differentiation. regulation of myeloid cell differentiation + + + + Any process that modulates the frequency, rate or extent of myeloid cell differentiation. + GOC:go_curators + @@ -53431,8 +79201,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. negative regulation of myeloid cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. + GOC:go_curators + @@ -53458,8 +79235,15 @@ + Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. positive regulation of myeloid cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. + GOC:go_curators + @@ -53484,8 +79268,15 @@ + Any process that modulates the frequency, rate or extent of erythrocyte differentiation. regulation of erythrocyte differentiation + + + + Any process that modulates the frequency, rate or extent of erythrocyte differentiation. + GOC:go_curators + @@ -53511,8 +79302,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation. negative regulation of erythrocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation. + GOC:go_curators + @@ -53538,8 +79336,15 @@ + Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. positive regulation of erythrocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. + GOC:go_curators + @@ -53564,8 +79369,15 @@ + Any process that modulates the frequency, rate or extent of macrophage differentiation. regulation of macrophage differentiation + + + + Any process that modulates the frequency, rate or extent of macrophage differentiation. + GOC:go_curators + @@ -53591,8 +79403,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation. negative regulation of macrophage differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation. + GOC:go_curators + @@ -53618,8 +79437,15 @@ + Any process that activates or increases the frequency, rate or extent of macrophage differentiation. positive regulation of macrophage differentiation + + + + Any process that activates or increases the frequency, rate or extent of macrophage differentiation. + GOC:go_curators + @@ -53644,8 +79470,15 @@ + Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. regulation of megakaryocyte differentiation + + + + Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. + GOC:go_curators + @@ -53671,8 +79504,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. negative regulation of megakaryocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. + GOC:go_curators + @@ -53698,8 +79538,15 @@ + Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. positive regulation of megakaryocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. + GOC:go_curators + @@ -53724,8 +79571,15 @@ + Any process that modulates the frequency, rate or extent of monocyte differentiation. regulation of monocyte differentiation + + + + Any process that modulates the frequency, rate or extent of monocyte differentiation. + GOC:go_curators + @@ -53751,8 +79605,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation. negative regulation of monocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation. + GOC:go_curators + @@ -53778,8 +79639,15 @@ + Any process that activates or increases the frequency, rate or extent of monocyte differentiation. positive regulation of monocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of monocyte differentiation. + GOC:go_curators + @@ -53804,8 +79672,17 @@ + Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. regulation of myoblast differentiation + + + + Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:go_curators + GOC:mtg_muscle + @@ -53831,8 +79708,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. negative regulation of myoblast differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:go_curators + GOC:mtg_muscle + @@ -53858,8 +79744,17 @@ + Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. positive regulation of myoblast differentiation + + + + Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:go_curators + GOC:mtg_muscle + @@ -53896,8 +79791,15 @@ + Any process that modulates the frequency, rate or extent of neuron differentiation. regulation of neuron differentiation + + + + Any process that modulates the frequency, rate or extent of neuron differentiation. + GOC:go_curators + @@ -53923,8 +79825,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. negative regulation of neuron differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. + GOC:go_curators + @@ -53950,8 +79859,15 @@ + Any process that activates or increases the frequency, rate or extent of neuron differentiation. positive regulation of neuron differentiation + + + + Any process that activates or increases the frequency, rate or extent of neuron differentiation. + GOC:go_curators + @@ -53976,8 +79892,15 @@ + Any process that modulates the frequency, rate or extent of osteoclast differentiation. regulation of osteoclast differentiation + + + + Any process that modulates the frequency, rate or extent of osteoclast differentiation. + GOC:go_curators + @@ -54003,8 +79926,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. negative regulation of osteoclast differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. + GOC:go_curators + @@ -54030,8 +79960,15 @@ + Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. positive regulation of osteoclast differentiation + + + + Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. + GOC:go_curators + @@ -54056,8 +79993,15 @@ + Any process that modulates the frequency, rate or extent of epidermis development. regulation of epidermis development + + + + Any process that modulates the frequency, rate or extent of epidermis development. + GOC:go_curators + @@ -54083,8 +80027,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. negative regulation of epidermis development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. + GOC:go_curators + @@ -54110,8 +80061,15 @@ + Any process that activates or increases the frequency, rate or extent of epidermis development. positive regulation of epidermis development + + + + Any process that activates or increases the frequency, rate or extent of epidermis development. + GOC:go_curators + @@ -54136,8 +80094,15 @@ + Any process that modulates the frequency, rate or extent of glia cell differentiation. regulation of glial cell differentiation + + + + Any process that modulates the frequency, rate or extent of glia cell differentiation. + GOC:go_curators + @@ -54163,8 +80128,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. negative regulation of glial cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. + GOC:go_curators + @@ -54190,8 +80162,119 @@ + Any process that activates or increases the frequency, rate or extent of glia cell differentiation. positive regulation of glial cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of glia cell differentiation. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + negative regulation of glycogen biosynthetic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. + negative regulation of gluconeogenesis + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of gluconeogenesis. + positive regulation of gluconeogenesis + + + + + Any process that activates or increases the frequency, rate or extent of gluconeogenesis. + GOC:go_curators + @@ -54218,8 +80301,51 @@ + Any process that activates or increases the frequency, rate or extent of the formation of a cilium. positive regulation of cilium assembly + + + + Any process that activates or increases the frequency, rate or extent of the formation of a cilium. + GOC:cilia + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + positive regulation of glycogen biosynthetic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators + @@ -54246,8 +80372,51 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. positive regulation of translation + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. + GOC:dph + GOC:go_curators + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + positive regulation of protein catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + GOC:go_curators + @@ -54273,8 +80442,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. negative regulation of action potential + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:go_curators + @@ -54300,8 +80476,15 @@ + Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. positive regulation of action potential + + + + Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:go_curators + @@ -54327,8 +80510,15 @@ + Any process that modulates the frequency, rate or extent of angiogenesis. regulation of angiogenesis + + + + Any process that modulates the frequency, rate or extent of angiogenesis. + GOC:go_curators + @@ -54354,8 +80544,15 @@ + Any process that activates or increases angiogenesis. positive regulation of angiogenesis + + + + Any process that activates or increases angiogenesis. + GOC:go_curators + @@ -54381,8 +80578,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division. negative regulation of asymmetric cell division + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division. + GOC:go_curators + @@ -54408,8 +80612,15 @@ + Any process that activates or increases the frequency, rate or extent of asymmetric cell division. positive regulation of asymmetric cell division + + + + Any process that activates or increases the frequency, rate or extent of asymmetric cell division. + GOC:go_curators + @@ -54435,8 +80646,15 @@ + Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. positive regulation of ossification + + + + Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators + @@ -54462,8 +80680,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. negative regulation of bone resorption + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. + GOC:go_curators + @@ -54489,8 +80714,15 @@ + Any process that activates or increases the frequency, rate or extent of bone resorption. positive regulation of bone resorption + + + + Any process that activates or increases the frequency, rate or extent of bone resorption. + GOC:go_curators + @@ -54516,8 +80748,15 @@ + Any process that activates or increases the frequency, rate or extent of cell adhesion. positive regulation of cell adhesion + + + + Any process that activates or increases the frequency, rate or extent of cell adhesion. + GOC:go_curators + @@ -54543,8 +80782,17 @@ + Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. negative regulation of cell cycle + + + + Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. + GOC:dph + GOC:go_curators + GOC:tb + @@ -54570,8 +80818,15 @@ + Any process that activates or increases the rate or extent of progression through the cell cycle. positive regulation of cell cycle + + + + Any process that activates or increases the rate or extent of progression through the cell cycle. + GOC:go_curators + @@ -54598,8 +80853,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. negative regulation of endocytosis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. + GOC:go_curators + @@ -54626,8 +80888,85 @@ + Any process that activates or increases the frequency, rate or extent of endocytosis. positive regulation of endocytosis + + + + Any process that activates or increases the frequency, rate or extent of endocytosis. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + negative regulation of glycogen catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + positive regulation of glycogen catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators + @@ -54653,8 +80992,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. negative regulation of heart contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. + GOC:go_curators + @@ -54680,8 +81026,15 @@ + Any process that activates or increases the frequency, rate or extent of heart contraction. positive regulation of heart contraction + + + + Any process that activates or increases the frequency, rate or extent of heart contraction. + GOC:go_curators + @@ -54707,8 +81060,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. negative regulation of lipid metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators + @@ -54734,8 +81094,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. positive regulation of lipid metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators + @@ -54763,8 +81130,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. negative regulation of meiotic nuclear division + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. + GOC:go_curators + @@ -54792,8 +81166,15 @@ + Any process that activates or increases the frequency, rate or extent of meiosis. positive regulation of meiotic nuclear division + + + + Any process that activates or increases the frequency, rate or extent of meiosis. + GOC:go_curators + @@ -54821,8 +81202,17 @@ + Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. negative regulation of mitotic nuclear division + + + + Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. + GOC:dph + GOC:go_curators + GOC:tb + @@ -54849,8 +81239,15 @@ + Any process that activates or increases the frequency, rate or extent of mitosis. positive regulation of mitotic nuclear division + + + + Any process that activates or increases the frequency, rate or extent of mitosis. + GOC:go_curators + @@ -54877,8 +81274,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development. negative regulation of striated muscle tissue development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development. + GOC:go_curators + @@ -54905,8 +81309,15 @@ + Any process that activates or increases the frequency, rate or extent of striated muscle development. positive regulation of striated muscle tissue development + + + + Any process that activates or increases the frequency, rate or extent of striated muscle development. + GOC:go_curators + @@ -54932,8 +81343,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. negative regulation of translational elongation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. + GOC:go_curators + @@ -54959,8 +81377,15 @@ + Any process that activates or increases the frequency, rate or extent of translational elongation. positive regulation of translational elongation + + + + Any process that activates or increases the frequency, rate or extent of translational elongation. + GOC:go_curators + @@ -54987,8 +81412,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination. negative regulation of translational termination + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination. + GOC:go_curators + @@ -55015,8 +81447,15 @@ + Any process that activates or increases the frequency, rate or extent of translational termination. positive regulation of translational termination + + + + Any process that activates or increases the frequency, rate or extent of translational termination. + GOC:go_curators + @@ -55042,8 +81481,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. negative regulation of carbohydrate metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + GOC:go_curators + @@ -55069,8 +81515,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. positive regulation of carbohydrate metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + GOC:go_curators + @@ -55096,8 +81549,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. negative regulation of catecholamine metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. + GOC:go_curators + @@ -55123,8 +81583,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. positive regulation of catecholamine metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. + GOC:go_curators + @@ -55150,8 +81617,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. negative regulation of exocytosis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. + GOC:go_curators + @@ -55177,8 +81651,15 @@ + Any process that activates or increases the frequency, rate or extent of exocytosis. positive regulation of exocytosis + + + + Any process that activates or increases the frequency, rate or extent of exocytosis. + GOC:go_curators + @@ -55204,8 +81685,15 @@ + Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. negative regulation of growth + + + + Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. + GOC:go_curators + @@ -55231,8 +81719,15 @@ + Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. positive regulation of growth + + + + Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. + GOC:go_curators + @@ -55258,8 +81753,17 @@ + Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. negative regulation of mitotic cell cycle + + + + Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. + GOC:dph + GOC:go_curators + GOC:tb + @@ -55285,8 +81789,17 @@ + Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. positive regulation of mitotic cell cycle + + + + Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. + GOC:dph + GOC:go_curators + GOC:tb + @@ -55312,8 +81825,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. negative regulation of muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. + GOC:go_curators + @@ -55339,8 +81859,15 @@ + Any process that activates or increases the frequency, rate or extent of muscle contraction. positive regulation of muscle contraction + + + + Any process that activates or increases the frequency, rate or extent of muscle contraction. + GOC:go_curators + @@ -55366,8 +81893,15 @@ + Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. negative regulation of nucleobase-containing compound metabolic process + + + + Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:go_curators + @@ -55393,8 +81927,83 @@ + Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. positive regulation of nucleobase-containing compound metabolic process + + + + Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. + negative regulation of steroid metabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. + positive regulation of steroid metabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators + @@ -55420,8 +82029,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. negative regulation of translational initiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. + GOC:go_curators + @@ -55447,8 +82063,15 @@ + Any process that activates or increases the frequency, rate or extent of translational initiation. positive regulation of translational initiation + + + + Any process that activates or increases the frequency, rate or extent of translational initiation. + GOC:go_curators + @@ -55474,8 +82097,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. negative regulation of smooth muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators + @@ -55501,8 +82131,15 @@ + Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. positive regulation of smooth muscle contraction + + + + Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators + @@ -55528,8 +82165,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. negative regulation of striated muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. + GOC:go_curators + @@ -55555,8 +82199,15 @@ + Any process that activates or increases the frequency, rate or extent of striated muscle contraction. positive regulation of striated muscle contraction + + + + Any process that activates or increases the frequency, rate or extent of striated muscle contraction. + GOC:go_curators + @@ -55583,8 +82234,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. negative regulation of embryonic development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. + GOC:go_curators + @@ -55609,8 +82267,15 @@ + Any process that modulates the frequency, rate or extent of embryonic development. regulation of embryonic development + + + + Any process that modulates the frequency, rate or extent of embryonic development. + GOC:go_curators + @@ -55635,8 +82300,15 @@ + Any process that modulates the frequency, rate or extent of resting T cell proliferation. regulation of T cell homeostatic proliferation + + + + Any process that modulates the frequency, rate or extent of resting T cell proliferation. + GOC:go_curators + @@ -55662,8 +82334,15 @@ + Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation. negative regulation of T cell homeostatic proliferation + + + + Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation. + GOC:go_curators + @@ -55688,8 +82367,82 @@ + The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. phenol-containing compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + carboxylic acid biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + carboxylic acid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + ISBN:0198506732 + @@ -55714,8 +82467,16 @@ + The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. photoreceptor cell differentiation + + + + The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. + GOC:ai + ISBN:0198506732 + @@ -55740,8 +82501,15 @@ + Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. regulation of photoreceptor cell differentiation + + + + Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. + GOC:go_curators + @@ -55768,8 +82536,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. negative regulation of photoreceptor cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. + GOC:go_curators + @@ -55796,8 +82571,15 @@ + Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. positive regulation of photoreceptor cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. + GOC:go_curators + @@ -55811,8 +82593,15 @@ + The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. development of primary female sexual characteristics + + + + The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. + GOC:ai + @@ -55843,8 +82632,15 @@ + Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. retinal rod cell development + + + + Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. + ISBN:0198506732 + @@ -55875,8 +82671,15 @@ + Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. retinal cone cell development + + + + Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. + ISBN:0198506732 + @@ -55902,8 +82705,16 @@ + Any process that modulates the frequency, rate or extent of growth of an organ of an organism. regulation of organ growth + + + + Any process that modulates the frequency, rate or extent of growth of an organ of an organism. + GOC:bf + GOC:tb + @@ -55930,8 +82741,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. negative regulation of organ growth + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. + GOC:bf + GOC:tb + @@ -55958,8 +82777,16 @@ + Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. positive regulation of organ growth + + + + Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. + GOC:bf + GOC:tb + @@ -55984,8 +82811,16 @@ + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. lymphocyte activation + + + + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. + GOC:mgi_curators + ISBN:0781735149 + @@ -56011,8 +82846,15 @@ + The expansion of a lymphocyte population by cell division. lymphocyte proliferation + + + + The expansion of a lymphocyte population by cell division. + GOC:ai + @@ -56026,8 +82868,15 @@ + The establishment of the sex of a female organism by physical differentiation. female sex differentiation + + + + The establishment of the sex of a female organism by physical differentiation. + GOC:bf + @@ -56041,8 +82890,15 @@ + Programmed cell death that occurs in the developing retina. retinal cell programmed cell death + + + + Programmed cell death that occurs in the developing retina. + GOC:bf + @@ -56073,8 +82929,15 @@ + Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium. compound eye retinal cell programmed cell death + + + + Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium. + PMID:12006672 + @@ -56100,8 +82963,16 @@ + Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina. regulation of retinal cell programmed cell death + + + + Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina. + GOC:ai + GOC:tb + @@ -56126,8 +82997,15 @@ + Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. regulation of compound eye retinal cell programmed cell death + + + + Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. + GOC:ai + @@ -56154,8 +83032,16 @@ + Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina. positive regulation of retinal cell programmed cell death + + + + Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina. + GOC:ai + GOC:tb + @@ -56182,8 +83068,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina. negative regulation of retinal cell programmed cell death + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina. + GOC:ai + GOC:tb + @@ -56209,8 +83103,15 @@ + Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. positive regulation of compound eye retinal cell programmed cell death + + + + Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. + GOC:ai + @@ -56236,8 +83137,50 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. negative regulation of compound eye retinal cell programmed cell death + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. + negative regulation of insulin secretion + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. + GOC:ai + @@ -56288,8 +83231,17 @@ + The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. muscle cell cellular homeostasis + + + + The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. + GOC:mah + PMID:3091429 + PMID:7781901 + @@ -56297,8 +83249,15 @@ + The controlled release of acid by a cell or a tissue. acid secretion + + + + The controlled release of acid by a cell or a tissue. + GOC:ai + @@ -56330,8 +83289,16 @@ + The addition of tubulin heterodimers to one or both ends of a microtubule. microtubule polymerization + + + + The addition of tubulin heterodimers to one or both ends of a microtubule. + GOC:ai + GOC:go_curators + @@ -56339,8 +83306,16 @@ + The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. + Wikipedia:Bone_remodeling bone remodeling + + + + The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. + GOC:curators + @@ -56383,8 +83358,15 @@ + Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. regulation of bone remodeling + + + + Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. + GOC:ai + @@ -56410,8 +83392,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. negative regulation of bone remodeling + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. + GOC:ai + @@ -56437,8 +83426,15 @@ + Any process that activates or increases the frequency, rate or extent of bone remodeling. positive regulation of bone remodeling + + + + Any process that activates or increases the frequency, rate or extent of bone remodeling. + GOC:ai + @@ -56447,8 +83443,15 @@ + The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. hormone secretion + + + + The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. + ISBN:0198506732 + @@ -56476,8 +83479,15 @@ + Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. regulation of hormone secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai + @@ -56505,8 +83515,15 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. positive regulation of hormone secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai + @@ -56534,8 +83551,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. negative regulation of hormone secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai + @@ -56562,8 +83586,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. positive regulation of lipid biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai + @@ -56589,8 +83620,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. regulation of lipid biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai + @@ -56598,8 +83636,15 @@ + The controlled release of a substance by a cell or a tissue. secretion + + + + The controlled release of a substance by a cell or a tissue. + GOC:ai + @@ -56626,8 +83671,94 @@ + The directed movement of substances within a cell. intracellular transport + + + + The directed movement of substances within a cell. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + carboxylic acid transport + + + + + The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + Reactome:R-HSA-390347 + carboxylic acid transmembrane transporter activity + + + + + Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + GOC:ai + + + + + Reactome:R-HSA-390347 + Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane + @@ -56651,8 +83782,16 @@ + The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. vesicle transport along microtubule + + + + The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. + GOC:ecd + GOC:rl + @@ -56661,8 +83800,15 @@ + The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. embryonic eye morphogenesis + + + + The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. + GOC:jid + @@ -56670,8 +83816,15 @@ + The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. developmental pigmentation + + + + The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. + ISBN:0582227089 + @@ -56696,8 +83849,17 @@ + Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. regulation of developmental pigmentation + + + + Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. + GOC:dph + GOC:jid + GOC:tb + @@ -56723,8 +83885,17 @@ + Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. negative regulation of developmental pigmentation + + + + Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. + GOC:dph + GOC:jid + GOC:tb + @@ -56750,8 +83921,17 @@ + Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. positive regulation of developmental pigmentation + + + + Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. + GOC:dph + GOC:jid + GOC:tb + @@ -56776,8 +83956,16 @@ + The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. somatic stem cell division + + + + The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. + GOC:jid + ISBN:0582227089 + @@ -56820,8 +84008,16 @@ + The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. female germ-line stem cell asymmetric division + + + + The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. + GOC:jid + GOC:mtg_sensu + @@ -56846,8 +84042,15 @@ + The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. fibroblast proliferation + + + + The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. + GOC:jid + @@ -56872,8 +84075,15 @@ + Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. regulation of fibroblast proliferation + + + + Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. + GOC:jid + @@ -56899,8 +84109,15 @@ + Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. positive regulation of fibroblast proliferation + + + + Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. + GOC:jid + @@ -56926,8 +84143,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. negative regulation of fibroblast proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. + GOC:jid + @@ -56952,8 +84176,17 @@ + The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. Golgi vesicle transport + + + + The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. + GOC:jid + ISBN:0716731363 + PMID:10219233 + @@ -56994,8 +84227,17 @@ + The evagination of the Golgi membrane, resulting in formation of a vesicle. Golgi vesicle budding + + + + The evagination of the Golgi membrane, resulting in formation of a vesicle. + GOC:jid + ISBN:0716731363 + PMID:10219233 + @@ -57036,8 +84278,18 @@ + The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. vesicle targeting, to, from or within Golgi + + + + The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. + GOC:jid + GOC:mah + ISBN:0716731363 + PMID:10219233 + @@ -57062,8 +84314,18 @@ + Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus. regulation of vesicle targeting, to, from or within Golgi + + + + Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus. + GOC:jid + GOC:mah + ISBN:0716731363 + PMID:10219233 + @@ -57084,8 +84346,16 @@ + The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. norepinephrine secretion + + + + The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. + GOC:ef + GOC:jid + @@ -57105,8 +84375,15 @@ + The movement of a macrophage in response to an external stimulus. macrophage chemotaxis + + + + The movement of a macrophage in response to an external stimulus. + GOC:jid + @@ -57126,8 +84403,17 @@ + The directed movement of a lymphocyte in response to an external stimulus. lymphocyte chemotaxis + + + + The directed movement of a lymphocyte in response to an external stimulus. + GOC:hjd + GOC:jid + PMID:12391252 + @@ -57152,8 +84438,17 @@ + Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. elastic fiber assembly + + + + Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. + GOC:jid + PMID:10841810 + PMID:12615674 + @@ -57195,8 +84490,15 @@ + The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. vesicle fusion with Golgi apparatus + + + + The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. + GOC:jid + @@ -57221,8 +84523,15 @@ + The creation of a single organelle from two or more organelles. organelle fusion + + + + The creation of a single organelle from two or more organelles. + GOC:jid + @@ -57247,8 +84556,15 @@ + The creation of two or more organelles by division of one organelle. organelle fission + + + + The creation of two or more organelles by division of one organelle. + GOC:jid + @@ -57279,8 +84595,16 @@ + The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. lung alveolus development + + + + The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. + GOC:mtg_lung + PMID:9751757 + @@ -57305,8 +84629,15 @@ + The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei. nuclear membrane fusion involved in karyogamy + + + + The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei. + GOC:jid + @@ -57314,8 +84645,15 @@ + The partitioning of organelles between daughter cells at cell division. organelle inheritance + + + + The partitioning of organelles between daughter cells at cell division. + GOC:jid + @@ -57341,8 +84679,16 @@ + The partitioning of Golgi apparatus between daughter cells at cell division. Golgi inheritance + + + + The partitioning of Golgi apparatus between daughter cells at cell division. + GOC:jid + PMID:12851069 + @@ -57367,8 +84713,15 @@ + The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. axial mesoderm development + + + + The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. + GOC:dgh + @@ -57399,8 +84752,15 @@ + The process in which the anatomical structures of the axial mesoderm are generated and organized. axial mesoderm morphogenesis + + + + The process in which the anatomical structures of the axial mesoderm are generated and organized. + GOC:go_curators + @@ -57431,8 +84791,15 @@ + The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. axial mesoderm formation + + + + The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:dgh + @@ -57463,8 +84830,15 @@ + The process in which the anatomical structures of the mesoderm are generated and organized. mesoderm morphogenesis + + + + The process in which the anatomical structures of the mesoderm are generated and organized. + GOC:go_curators + @@ -57495,8 +84869,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. mesodermal cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. + GOC:dgh + @@ -57522,8 +84903,15 @@ + The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. paraxial mesoderm development + + + + The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. + GOC:dgh + @@ -57555,8 +84943,15 @@ + The process in which the anatomical structures of the paraxial mesoderm are generated and organized. paraxial mesoderm morphogenesis + + + + The process in which the anatomical structures of the paraxial mesoderm are generated and organized. + GOC:go_curators + @@ -57587,8 +84982,15 @@ + The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. paraxial mesoderm formation + + + + The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:dgh + @@ -57614,8 +85016,15 @@ + The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. lateral mesoderm development + + + + The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. + GOC:go_curators + @@ -57647,8 +85056,15 @@ + The process in which the anatomical structures of the lateral mesoderm are generated and organized. lateral mesoderm morphogenesis + + + + The process in which the anatomical structures of the lateral mesoderm are generated and organized. + GOC:go_curators + @@ -57679,8 +85095,15 @@ + The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts. lateral mesoderm formation + + + + The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:jid + @@ -57705,8 +85128,15 @@ + The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. intermediate mesoderm development + + + + The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. + GOC:dgh + @@ -57737,8 +85167,15 @@ + The process in which the anatomical structures of the intermediate mesoderm are generated and organized. intermediate mesoderm morphogenesis + + + + The process in which the anatomical structures of the intermediate mesoderm are generated and organized. + GOC:go_curators + @@ -57769,8 +85206,15 @@ + The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts. intermediate mesoderm formation + + + + The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:dgh + @@ -57802,8 +85246,15 @@ + The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place. cell development + + + + The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place. + GOC:go_curators + @@ -57835,8 +85286,15 @@ + The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state. cell maturation + + + + The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state. + GOC:go_curators + @@ -57874,8 +85332,18 @@ + The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. + Wikipedia:Oogenesis oogenesis + + + + The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. + GOC:kmv + GOC:mtg_sensu + GOC:pr + @@ -57906,8 +85374,17 @@ + The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. autonomic nervous system development + + + + The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. + FMA:9905 + GOC:jid + GOC:sr + @@ -57938,8 +85415,17 @@ + The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. sympathetic nervous system development + + + + The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. + FMA:9906 + GOC:jid + GOC:sr + @@ -57948,8 +85434,18 @@ + The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. regulation of timing of cell differentiation + + + + The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. + GOC:bf + GOC:dph + GOC:jid + GOC:tb + @@ -57957,8 +85453,17 @@ + Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + Wikipedia:Organogenesis animal organ development + + + + Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:dph + GOC:jid + @@ -57989,8 +85494,15 @@ + The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. blood vessel morphogenesis + + + + The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. + GOC:jid + @@ -58015,8 +85527,15 @@ + Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. positive regulation of biological process + + + + Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:jid + @@ -58041,8 +85560,85 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. negative regulation of biological process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:jid + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + positive regulation of behavior + + + + + Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:jid + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + negative regulation of behavior + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:jid + GOC:pr + @@ -58068,8 +85664,15 @@ + Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. positive regulation of cellular process + + + + Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:jid + @@ -58095,8 +85698,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. negative regulation of cellular process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:jid + @@ -58110,8 +85720,51 @@ + The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. hematopoietic or lymphoid organ development + + + + The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. + GOC:add + GOC:rl + ISBN:0781735149 + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. + spleen development + + + + + The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. + GOC:add + ISBN:0781735149 + @@ -58143,8 +85796,16 @@ + The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. bone marrow development + + + + The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. + GOC:add + ISBN:0781735149 + @@ -58169,8 +85830,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. response to steroid hormone + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. + GOC:go_curators + @@ -58201,8 +85869,17 @@ + The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. digestive tract morphogenesis + + + + The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. + GOC:dph + GOC:go_curators + PMID:12618131 + @@ -58217,8 +85894,15 @@ + Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. embryonic organ morphogenesis + + + + Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:jid + @@ -58249,8 +85933,15 @@ + The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. digestive tract development + + + + The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. + GOC:go_curators + @@ -58285,8 +85976,15 @@ + Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. embryonic organ development + + + + Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:jid + @@ -58317,8 +86015,15 @@ + The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. notochord morphogenesis + + + + The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. + GOC:jid + @@ -58343,8 +86048,15 @@ + Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. regulation of post-embryonic development + + + + Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid + @@ -58371,8 +86083,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. negative regulation of post-embryonic development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid + @@ -58399,8 +86118,15 @@ + Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. positive regulation of post-embryonic development + + + + Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid + @@ -58425,8 +86151,16 @@ + Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of response to stimulus + + + + Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid + @@ -58452,8 +86186,16 @@ + Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of response to stimulus + + + + Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid + @@ -58479,8 +86221,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of response to stimulus + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid + @@ -58495,8 +86245,16 @@ + The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. developmental cell growth + + + + The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. + GOC:go_curators + GOC:isa_complete + @@ -58521,8 +86279,15 @@ + The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. developmental growth + + + + The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. + GOC:go_curators + @@ -58553,8 +86318,16 @@ + The process in which the anatomical structures of the eye are generated and organized. eye morphogenesis + + + + The process in which the anatomical structures of the eye are generated and organized. + GOC:jid + GOC:mtg_sensu + @@ -58585,8 +86358,16 @@ + The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. camera-type eye morphogenesis + + + + The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. + GOC:jid + GOC:mtg_sensu + @@ -58606,8 +86387,16 @@ + The process in which the anatomical structures of the eye are generated and organized during embryonic development. embryonic camera-type eye morphogenesis + + + + The process in which the anatomical structures of the eye are generated and organized during embryonic development. + GOC:jid + GOC:mtg_sensu + @@ -58621,8 +86410,16 @@ + The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. embryonic morphogenesis + + + + The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. + GOC:jid + GOC:mtg_sensu + @@ -58653,8 +86450,15 @@ + The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. oocyte development + + + + The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:go_curators + @@ -58698,8 +86502,15 @@ + The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte. oocyte morphogenesis + + + + The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte. + GOC:go_curators + @@ -58714,8 +86525,17 @@ + The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. reproductive structure development + + + + The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. + GOC:dph + GOC:isa_complete + GOC:jid + @@ -58723,8 +86543,17 @@ + The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. multicellular organismal reproductive process + + + + The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. + GOC:dph + GOC:jid + GOC:tb + @@ -58755,8 +86584,17 @@ + The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. myoblast development + + + + The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:dph + GOC:mtg_muscle + @@ -58787,8 +86625,17 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. myoblast maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:dph + GOC:mtg_muscle + @@ -58819,8 +86666,17 @@ + The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. skeletal muscle tissue growth + + + + The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. + GOC:lm + PMID:15726494 + PMID:15907921 + @@ -58845,8 +86701,17 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle growth. regulation of skeletal muscle tissue growth + + + + Any process that modulates the frequency, rate or extent of skeletal muscle growth. + GOC:lm + PMID:15726494 + PMID:15907921 + @@ -58872,8 +86737,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth. negative regulation of skeletal muscle tissue growth + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth. + GOC:lm + PMID:15726494 + PMID:15907921 + @@ -58900,8 +86774,17 @@ + Any process that activates, maintains or increases the rate of skeletal muscle growth. positive regulation of skeletal muscle tissue growth + + + + Any process that activates, maintains or increases the rate of skeletal muscle growth. + GOC:lm + PMID:15726494 + PMID:15907921 + @@ -58926,8 +86809,15 @@ + Any process that modulates the frequency, rate or extent of muscle development. regulation of muscle organ development + + + + Any process that modulates the frequency, rate or extent of muscle development. + GOC:go_curators + @@ -58954,8 +86844,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. negative regulation of muscle organ development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. + GOC:go_curators + @@ -58982,8 +86879,15 @@ + Any process that activates, maintains or increases the rate of muscle development. positive regulation of muscle organ development + + + + Any process that activates, maintains or increases the rate of muscle development. + GOC:go_curators + @@ -59009,8 +86913,15 @@ + Any process that modulates the frequency, rate or extent of developmental growth. regulation of developmental growth + + + + Any process that modulates the frequency, rate or extent of developmental growth. + GOC:go_curators + @@ -59037,8 +86948,15 @@ + Any process that activates, maintains or increases the rate of developmental growth. positive regulation of developmental growth + + + + Any process that activates, maintains or increases the rate of developmental growth. + GOC:go_curators + @@ -59065,8 +86983,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. negative regulation of developmental growth + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. + GOC:go_curators + @@ -59091,8 +87016,15 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. regulation of skeletal muscle tissue development + + + + Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. + GOC:go_curators + @@ -59118,8 +87050,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. negative regulation of skeletal muscle tissue development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. + GOC:go_curators + @@ -59145,8 +87084,15 @@ + Any process that activates, maintains or increases the rate of skeletal muscle tissue development. positive regulation of skeletal muscle tissue development + + + + Any process that activates, maintains or increases the rate of skeletal muscle tissue development. + GOC:go_curators + @@ -59177,8 +87123,15 @@ + The process in which the anatomical structures of muscle are generated and organized. muscle organ morphogenesis + + + + The process in which the anatomical structures of muscle are generated and organized. + GOC:jid + @@ -59209,8 +87162,16 @@ + The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. animal organ formation + + + + The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. + GOC:dph + GOC:jid + @@ -59224,8 +87185,18 @@ + The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. anatomical structure formation involved in morphogenesis + + + + The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GOC:dph + GOC:jid + GOC:tb + @@ -59250,8 +87221,17 @@ + The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population. smooth muscle cell proliferation + + + + The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population. + CL:0000192 + GOC:ebc + PMID:1840698 + @@ -59276,8 +87256,16 @@ + Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. regulation of smooth muscle cell proliferation + + + + Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. + CL:0000192 + GOC:ebc + @@ -59303,8 +87291,16 @@ + Any process that activates or increases the rate or extent of smooth muscle cell proliferation. positive regulation of smooth muscle cell proliferation + + + + Any process that activates or increases the rate or extent of smooth muscle cell proliferation. + CL:0000192 + GOC:ebc + @@ -59330,8 +87326,16 @@ + Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. negative regulation of smooth muscle cell proliferation + + + + Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. + CL:0000192 + GOC:ebc + @@ -59362,8 +87366,15 @@ + The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. neuron development + + + + The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + GOC:dph + @@ -59388,8 +87399,16 @@ + The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. cell morphogenesis involved in neuron differentiation + + + + The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. + GOC:dph + GOC:tb + @@ -59397,8 +87416,15 @@ + The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. generation of neurons + + + + The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. + GOC:nln + @@ -59429,8 +87455,18 @@ + The process in which the anatomical structures of the skeleton are generated and organized. skeletal system morphogenesis + + + + The process in which the anatomical structures of the skeleton are generated and organized. + GOC:dph + GOC:dsf + GOC:jid + GOC:tb + @@ -59461,8 +87497,16 @@ + The process in which the anatomical structures of a tissue are generated and organized. tissue morphogenesis + + + + The process in which the anatomical structures of a tissue are generated and organized. + GOC:dph + GOC:jid + @@ -59493,8 +87537,16 @@ + The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. epidermis morphogenesis + + + + The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. + GOC:jid + UBERON:0001003 + @@ -59525,8 +87577,16 @@ + The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. system development + + + + The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. + GOC:dph + GOC:jid + @@ -59551,8 +87611,15 @@ + The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. gland development + + + + The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. + GOC:jid + @@ -59583,8 +87650,16 @@ + The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. appendage development + + + + The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. + GOC:jid + GOC:rc + @@ -59615,8 +87690,17 @@ + The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. cardiac muscle tissue development + + + + The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. + GOC:dph + GOC:jid + GOC:lm + @@ -59647,8 +87731,19 @@ + The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. skeletal muscle fiber development + + + + The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. + GOC:dph + GOC:ef + GOC:jid + GOC:lm + GOC:mtg_muscle + @@ -59674,8 +87769,18 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. regulation of skeletal muscle fiber development + + + + Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. + GOC:dph + GOC:jid + GOC:mtg_muscle + GOC:sm + @@ -59703,8 +87808,18 @@ + Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. positive regulation of skeletal muscle fiber development + + + + Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. + GOC:dph + GOC:jid + GOC:lm + GOC:mtg_muscle + @@ -59731,8 +87846,18 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. negative regulation of skeletal muscle fiber development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. + GOC:dph + GOC:jid + GOC:lm + GOC:mtg_muscle + @@ -59757,8 +87882,17 @@ + The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. smooth muscle tissue development + + + + The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. + GOC:dph + GOC:jid + GOC:lm + @@ -59783,8 +87917,17 @@ + The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye. compound eye development + + + + The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye. + GOC:jid + GOC:mtg_sensu + Wikipedia:Eye + @@ -59815,8 +87958,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. pigment granule organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. + GOC:rc + @@ -59842,8 +87992,17 @@ + The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. branching morphogenesis of an epithelial tube + + + + The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. + GOC:dgh + GOC:dph + GOC:jid + @@ -59874,8 +88033,17 @@ + The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). branching morphogenesis of a nerve + + + + The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). + GOC:dgh + GOC:dph + GOC:jid + @@ -59906,8 +88074,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. mesenchymal cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. + GOC:dph + GOC:jid + @@ -59915,8 +88091,16 @@ + A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. pigment granule + + + + A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. + GOC:jid + GOC:mh + @@ -59924,8 +88108,15 @@ + The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. tissue remodeling + + + + The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. + GOC:ebc + @@ -59956,8 +88147,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. animal organ maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. + GOC:curators + @@ -59972,8 +88170,15 @@ + The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. genitalia development + + + + The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. + GOC:jid + @@ -60004,8 +88209,15 @@ + The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. neuron projection morphogenesis + + + + The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. + GOC:mah + @@ -60036,8 +88248,15 @@ + The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. erythrocyte development + + + + The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. + GOC:devbiol + @@ -60068,8 +88287,15 @@ + The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. nucleate erythrocyte development + + + + The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + GOC:devbiol + @@ -60100,8 +88326,16 @@ + The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. artery morphogenesis + + + + The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. + GOC:dsf + PMID:16740480 + @@ -60132,8 +88366,16 @@ + The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. venous blood vessel morphogenesis + + + + The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. + GOC:dsf + PMID:16740480 + @@ -60164,8 +88406,16 @@ + The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). brain morphogenesis + + + + The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). + GOC:dgh + GOC:jid + @@ -60190,8 +88440,15 @@ + The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. anatomical structure development + + + + The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GO_REF:0000021 + @@ -60216,8 +88473,15 @@ + The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. neural nucleus development + + + + The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. + GO_REF:0000021 + @@ -60249,8 +88513,15 @@ + The process in which the anatomical structures of a cell projection are generated and organized. cell projection morphogenesis + + + + The process in which the anatomical structures of a cell projection are generated and organized. + GO_REF:0000021 + @@ -60275,8 +88546,15 @@ + The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. formation of anatomical boundary + + + + The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GO_REF:0000021 + @@ -60327,8 +88605,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + Wikipedia:Stem_cell_differentiation stem cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + CL:0000034 + GOC:isa_complete + @@ -60359,8 +88646,16 @@ + The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. stem cell development + + + + The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. + CL:0000034 + GOC:isa_complete + @@ -60369,8 +88664,15 @@ + A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. cellular developmental process + + + + A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. + GOC:isa_complete + @@ -60404,8 +88706,18 @@ + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. cell motility + + + + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. + GOC:dgh + GOC:dph + GOC:isa_complete + GOC:mlg + @@ -60414,8 +88726,15 @@ + Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. multicellular organismal-level homeostasis + + + + Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. + GOC:isa_complete + @@ -60423,8 +88742,15 @@ + Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. homeostasis of number of cells + + + + Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. + GOC:isa_complete + @@ -60433,8 +88759,48 @@ + Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. homeostasis of number of cells within a tissue + + + + Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. + GOC:isa_complete + + + + + + + + + + + + + + + + + + + + + + + + + + Any biological process involved in the maintenance of an internal steady state of a chemical. + chemical homeostasis + + + + + Any biological process involved in the maintenance of an internal steady state of a chemical. + GOC:isa_complete + @@ -60459,8 +88825,15 @@ + The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. sensory system development + + + + The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. + GOC:dgh + @@ -60491,8 +88864,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. peripheral nervous system neuron differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. + GOC:dgh + @@ -60523,8 +88903,15 @@ + The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. peripheral nervous system neuron development + + + + The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. + GOC:dgh + @@ -60549,8 +88936,15 @@ + Any process in which a chromosome is transported to, or maintained in, a specific location. chromosome localization + + + + Any process in which a chromosome is transported to, or maintained in, a specific location. + GOC:ai + @@ -60570,8 +88964,16 @@ + The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. catecholamine secretion + + + + The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:ai + GOC:ef + @@ -60597,8 +88999,15 @@ + Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. regulation of catecholamine secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. + GOC:ai + @@ -60624,8 +89033,15 @@ + The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RNA transport + + + + The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -60651,8 +89067,15 @@ + Any process that modulates the frequency, rate or extent of lymphocyte proliferation. regulation of lymphocyte proliferation + + + + Any process that modulates the frequency, rate or extent of lymphocyte proliferation. + GOC:ai + @@ -60679,8 +89102,15 @@ + Any process that activates or increases the rate or extent of lymphocyte proliferation. positive regulation of lymphocyte proliferation + + + + Any process that activates or increases the rate or extent of lymphocyte proliferation. + GOC:ai + @@ -60707,8 +89137,15 @@ + Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. negative regulation of lymphocyte proliferation + + + + Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. + GOC:ai + @@ -60733,8 +89170,15 @@ + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. epithelial cell proliferation + + + + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. + ISBN:0721662544 + @@ -60759,8 +89203,15 @@ + Any process that modulates the frequency, rate or extent of epithelial cell proliferation. regulation of epithelial cell proliferation + + + + Any process that modulates the frequency, rate or extent of epithelial cell proliferation. + GOC:ai + @@ -60786,8 +89237,15 @@ + Any process that activates or increases the rate or extent of epithelial cell proliferation. positive regulation of epithelial cell proliferation + + + + Any process that activates or increases the rate or extent of epithelial cell proliferation. + GOC:ai + @@ -60813,8 +89271,15 @@ + Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. negative regulation of epithelial cell proliferation + + + + Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. + GOC:ai + @@ -60840,8 +89305,15 @@ + Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. regulation of protein secretion + + + + Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai + @@ -60868,8 +89340,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. negative regulation of protein secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai + @@ -60896,8 +89375,15 @@ + Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. positive regulation of protein secretion + + + + Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai + @@ -60923,8 +89409,15 @@ + Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. regulation of inflammatory response + + + + Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. + GOC:ai + @@ -60951,8 +89444,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. negative regulation of inflammatory response + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. + GOC:ai + @@ -60979,8 +89479,15 @@ + Any process that activates or increases the frequency, rate or extent of the inflammatory response. positive regulation of inflammatory response + + + + Any process that activates or increases the frequency, rate or extent of the inflammatory response. + GOC:ai + @@ -61005,8 +89512,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. regulation of lipoprotein metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. + GOC:ai + @@ -61032,8 +89546,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. positive regulation of lipoprotein metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. + GOC:ai + @@ -61059,8 +89580,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. negative regulation of lipoprotein metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. + GOC:ai + @@ -61111,8 +89639,15 @@ + Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. regulation of phagocytosis + + + + Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. + GOC:ai + @@ -61138,8 +89673,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. negative regulation of phagocytosis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. + GOC:ai + @@ -61165,8 +89707,15 @@ + Any process that activates or increases the frequency, rate or extent of phagocytosis. positive regulation of phagocytosis + + + + Any process that activates or increases the frequency, rate or extent of phagocytosis. + GOC:ai + @@ -61192,8 +89741,15 @@ + Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. regulation of neurogenesis + + + + Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. + GOC:ai + @@ -61220,8 +89776,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. negative regulation of neurogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. + GOC:ai + @@ -61248,8 +89811,15 @@ + Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. positive regulation of neurogenesis + + + + Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. + GOC:ai + @@ -61275,8 +89845,15 @@ + Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. regulation of immune response + + + + Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai + @@ -61303,8 +89880,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. negative regulation of immune response + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai + @@ -61331,8 +89915,15 @@ + Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. positive regulation of immune response + + + + Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai + @@ -61357,8 +89948,51 @@ + Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. regulation of biological process + + + + Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:ai + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the activity of an enzyme. + regulation of catalytic activity + + + + + Any process that modulates the activity of an enzyme. + GOC:ai + GOC:ebc + GOC:vw + @@ -61383,8 +90017,15 @@ + Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). regulation of developmental process + + + + Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:go_curators + @@ -61409,8 +90050,116 @@ + Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. regulation of cellular process + + + + Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + regulation of behavior + + + + + Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:go_curators + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the regulated release of insulin. + regulation of insulin secretion + + + + + Any process that modulates the frequency, rate or extent of the regulated release of insulin. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + monoatomic ion homeostasis + + + + + Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + GOC:ai + @@ -61429,8 +90178,15 @@ + Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). regulation of synapse structure or activity + + + + Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). + GOC:ai + @@ -61455,8 +90211,15 @@ + Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. modulation of chemical synaptic transmission + + + + Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. + GOC:ai + @@ -61483,8 +90246,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. negative regulation of synaptic transmission + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. + GOC:ai + @@ -61511,8 +90281,15 @@ + Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. positive regulation of synaptic transmission + + + + Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. + GOC:ai + @@ -61543,8 +90320,17 @@ + Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). regulation of synapse organization + + + + Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). + GOC:ai + GOC:dph + GOC:tb + @@ -61569,8 +90355,50 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). synapse organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). + GOC:ai + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + regulation of steroid biosynthetic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:ai + @@ -61590,8 +90418,15 @@ + Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. defense response to fungus + + + + Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. + GOC:ai + @@ -61616,8 +90451,15 @@ + Any process that modulates the frequency, rate or extent of T cell activation. regulation of T cell activation + + + + Any process that modulates the frequency, rate or extent of T cell activation. + GOC:ai + @@ -61669,8 +90511,15 @@ + Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. regulation of cell activation + + + + Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. + GOC:ai + @@ -61697,8 +90546,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. negative regulation of cell activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. + GOC:ai + @@ -61725,8 +90581,15 @@ + Any process that activates or increases the frequency, rate or extent of activation. positive regulation of cell activation + + + + Any process that activates or increases the frequency, rate or extent of activation. + GOC:ai + @@ -61753,8 +90616,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. negative regulation of T cell activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. + GOC:ai + @@ -61845,8 +90715,15 @@ + Any process that activates or increases the frequency, rate or extent of T cell activation. positive regulation of T cell activation + + + + Any process that activates or increases the frequency, rate or extent of T cell activation. + GOC:ai + @@ -61883,8 +90760,33 @@ + A organ system process carried out by any of the organs or tissues of neurological system. nervous system process + + + + A organ system process carried out by any of the organs or tissues of neurological system. + GOC:ai + GOC:mtg_cardio + + + + + + + + Any process that modulates the levels of body fluids. + regulation of body fluid levels + + + + + Any process that modulates the levels of body fluids. + GOC:ai + GOC:dph + GOC:tb + @@ -61892,8 +90794,17 @@ + Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. multicellular organismal movement + + + + Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. + GOC:dph + GOC:mtg_muscle + GOC:tb + @@ -61902,9 +90813,15 @@ - + The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. musculoskeletal movement + + + + The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. + GOC:dph + @@ -61912,8 +90829,32 @@ + The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. endocrine process + + + + The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + ISBN:0721662544 + + + + + + + + + The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. + Wikipedia:Cognition + cognition + + + + + The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. + ISBN:0721619908 + @@ -61921,8 +90862,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. + GOC:ai + GOC:bf + @@ -61960,8 +90910,20 @@ + The movement of a leukocyte within or between different tissues and organs of the body. leukocyte migration + + + + The movement of a leukocyte within or between different tissues and organs of the body. + GOC:add + ISBN:0781735149 + PMID:14680625 + PMID:14708592 + PMID:7507411 + PMID:8600538 + @@ -61969,8 +90931,15 @@ + Any process pertaining to the functions of the nervous and muscular systems of an organism. neuromuscular process + + + + Any process pertaining to the functions of the nervous and muscular systems of an organism. + GOC:ai + @@ -61995,8 +90964,18 @@ + The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. + Wikipedia:Transduction_(physiology) detection of stimulus involved in sensory perception + + + + The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + GOC:dph + @@ -62022,8 +91001,16 @@ + The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. detection of chemical stimulus involved in sensory perception + + + + The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. + GOC:ai + GOC:dos + @@ -62049,8 +91036,16 @@ + The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. detection of light stimulus involved in visual perception + + + + The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + @@ -62076,8 +91071,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. regulation of chemotaxis + + + + Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. + GOC:ai + @@ -62104,8 +91106,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. positive regulation of chemotaxis + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. + GOC:ai + @@ -62132,8 +91141,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. negative regulation of chemotaxis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. + GOC:ai + @@ -62164,8 +91180,16 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. + Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. pigment cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. + GOC:dgh + @@ -62190,8 +91214,15 @@ + Any process that modulates the frequency, rate or extent of pigmented cell differentiation. regulation of pigment cell differentiation + + + + Any process that modulates the frequency, rate or extent of pigmented cell differentiation. + GOC:ai + @@ -62218,8 +91249,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation. negative regulation of pigment cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation. + GOC:ai + @@ -62246,8 +91284,15 @@ + Any process that activates or increases the frequency, rate or extent of pigment cell differentiation. positive regulation of pigment cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of pigment cell differentiation. + GOC:ai + @@ -62255,8 +91300,15 @@ + The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. sensory perception of light stimulus + + + + The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + @@ -62264,8 +91316,15 @@ + The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. sensory perception of mechanical stimulus + + + + The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + @@ -62291,8 +91350,16 @@ + The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. detection of light stimulus involved in sensory perception + + + + The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. + GOC:ai + GOC:dos + @@ -62312,8 +91379,15 @@ + The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. detection of chemical stimulus involved in sensory perception of pain + + + + The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. + GOC:ai + @@ -62321,8 +91395,117 @@ + The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). + Wikipedia:Touch sensory perception of touch + + + + The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + regulation of lipid catabolic process + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + negative regulation of lipid catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + positive regulation of lipid catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + GOC:ai + @@ -62348,8 +91531,15 @@ + The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. actin filament bundle assembly + + + + The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. + GOC:ai + @@ -62374,8 +91564,100 @@ + The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. DNA transport + + + + The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. + Reactome:R-HSA-203906 + RNA transmembrane transporter activity + + + + + Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. + GOC:ai + + + + + Reactome:R-HSA-203906 + Exportin complex translocates pre-miRNA to cytosol + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other. + DNA transmembrane transporter activity + + + + + Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other. + GOC:ai + @@ -62400,8 +91682,15 @@ + Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. regulation of secretion + + + + Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai + @@ -62427,8 +91716,15 @@ + Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. positive regulation of secretion + + + + Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai + @@ -62454,8 +91750,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. negative regulation of secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai + @@ -62480,8 +91783,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -62507,8 +91817,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -62534,8 +91851,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -62560,8 +91884,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. regulation of DNA metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. + GOC:ai + @@ -62587,8 +91918,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. negative regulation of DNA metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. + GOC:ai + @@ -62614,8 +91952,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. positive regulation of DNA metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. + GOC:ai + @@ -62642,8 +91987,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. negative regulation of lipid biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai + @@ -62663,8 +92015,15 @@ + The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs. meiotic nuclear membrane disassembly + + + + The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs. + GOC:bf + @@ -62695,8 +92054,15 @@ + The controlled breakdown of the nuclear membranes, for example during cellular division. nuclear membrane disassembly + + + + The controlled breakdown of the nuclear membranes, for example during cellular division. + GOC:ai + @@ -62722,8 +92088,15 @@ + Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). negative regulation of developmental process + + + + Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:ai + @@ -62749,8 +92122,15 @@ + Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). positive regulation of developmental process + + + + Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:ai + @@ -62775,8 +92155,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. regulation of cellular component organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + GOC:ai + @@ -62802,8 +92189,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. negative regulation of cellular component organization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + GOC:ai + @@ -62829,8 +92223,15 @@ + Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. positive regulation of cellular component organization + + + + Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + GOC:ai + @@ -62855,8 +92256,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. smooth muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. + CL:0000192 + GOC:ai + @@ -62881,8 +92290,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. striated muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. + CL:0000737 + GOC:ai + @@ -62907,8 +92324,16 @@ + Any process that modulates the frequency, rate or extent of muscle cell differentiation. regulation of muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of muscle cell differentiation. + CL:0000187 + GOC:ai + @@ -62934,8 +92359,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. negative regulation of muscle cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. + CL:0000187 + GOC:ai + @@ -62961,8 +92394,16 @@ + Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. positive regulation of muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. + CL:0000187 + GOC:ai + @@ -62987,8 +92428,16 @@ + Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. regulation of smooth muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. + CL:0000192 + GOC:ai + @@ -63014,8 +92463,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation. negative regulation of smooth muscle cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation. + CL:0000192 + GOC:ai + @@ -63041,8 +92498,16 @@ + Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. positive regulation of smooth muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. + CL:0000192 + GOC:ai + @@ -63067,8 +92532,16 @@ + Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. regulation of striated muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. + CL:0000737 + GOC:ai + @@ -63094,8 +92567,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. negative regulation of striated muscle cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. + CL:0000737 + GOC:ai + @@ -63121,8 +92602,16 @@ + Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. positive regulation of striated muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. + CL:0000737 + GOC:ai + @@ -63151,8 +92640,16 @@ + The directed movement of substances into, out of, or within the nucleus. + Wikipedia:Nuclear_transport nuclear transport + + + + The directed movement of substances into, out of, or within the nucleus. + GOC:ai + @@ -63160,8 +92657,16 @@ + Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. localization + + + + Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. + GOC:ai + GOC:dos + @@ -63198,8 +92703,17 @@ + The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + Wikipedia:Chondrogenesis cartilage development + + + + The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:cjm + PMID:23251424 + @@ -63226,8 +92740,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of protein transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -63253,8 +92774,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of protein transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -63281,8 +92809,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of protein transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -63290,8 +92825,16 @@ + Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. establishment of localization + + + + Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. + GOC:ai + GOC:dos + @@ -63305,8 +92848,15 @@ + The directed movement of RNA to a specific location. establishment of RNA localization + + + + The directed movement of RNA to a specific location. + GOC:ai + @@ -63331,8 +92881,17 @@ + Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. regulation of multicellular organismal process + + + + Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai + GOC:dph + GOC:tb + @@ -63358,8 +92917,15 @@ + Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. positive regulation of multicellular organismal process + + + + Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai + @@ -63385,8 +92951,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. negative regulation of multicellular organismal process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai + @@ -63411,8 +92984,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. regulation of protein metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. + GOC:ai + @@ -63438,8 +93018,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. positive regulation of protein metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. + GOC:ai + @@ -63465,8 +93052,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. negative regulation of protein metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. + GOC:ai + @@ -63491,8 +93085,15 @@ + Any process that modulates the frequency, rate or extent of lymphocyte activation. regulation of lymphocyte activation + + + + Any process that modulates the frequency, rate or extent of lymphocyte activation. + GOC:ai + @@ -63518,8 +93119,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. negative regulation of lymphocyte activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. + GOC:ai + @@ -63545,8 +93153,15 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte activation. positive regulation of lymphocyte activation + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte activation. + GOC:ai + @@ -63571,8 +93186,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. regulation of RNA metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. + GOC:ai + @@ -63598,8 +93220,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. negative regulation of RNA metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. + GOC:ai + @@ -63625,8 +93254,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. positive regulation of RNA metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. + GOC:ai + @@ -63634,8 +93270,15 @@ + The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. protein polymerization + + + + The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. + GOC:ai + @@ -63643,8 +93286,15 @@ + The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. protein depolymerization + + + + The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. + GOC:ai + @@ -63669,8 +93319,18 @@ + A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. chromosome organization + + + + A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. + GOC:ai + GOC:dph + GOC:jl + GOC:mah + @@ -63678,8 +93338,19 @@ + The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. + Wikipedia:Cell_division + Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. cell division + + + + The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. + GOC:di + GOC:go_curators + GOC:pr + @@ -63704,8 +93375,15 @@ + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. regulation of cell division + + + + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. + GOC:go_curators + @@ -63726,8 +93404,15 @@ + The directed movement of a chromosome to a specific location. establishment of chromosome localization + + + + The directed movement of a chromosome to a specific location. + GOC:ai + @@ -63771,8 +93456,118 @@ + Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. + Wikipedia:Meiosis + Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. meiotic cell cycle + + + + Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. + regulation of hydrolase activity + + + + + Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. + positive regulation of hydrolase activity + + + + + Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. + negative regulation of hydrolase activity + + + + + Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. + GOC:ai + @@ -63797,8 +93592,55 @@ + Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. neuron apoptotic process + + + + Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. + CL:0000540 + GOC:mtg_apoptosis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. + detoxification of nitrogen compound + + + + + Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. + GOC:ai + @@ -63824,8 +93666,17 @@ + Any process that modulates the rate or extent of progression through the meiotic cell cycle. regulation of meiotic cell cycle + + + + Any process that modulates the rate or extent of progression through the meiotic cell cycle. + GOC:ai + GOC:dph + GOC:tb + @@ -63852,8 +93703,17 @@ + Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. positive regulation of meiotic cell cycle + + + + Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. + GOC:ai + GOC:dph + GOC:tb + @@ -63880,8 +93740,17 @@ + Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. negative regulation of meiotic cell cycle + + + + Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. + GOC:ai + GOC:dph + GOC:tb + @@ -63906,8 +93775,17 @@ + The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. myoblast proliferation + + + + The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:ai + GOC:mtg_muscle + @@ -63932,8 +93810,17 @@ + The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. myoblast migration + + + + The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:ai + GOC:mtg_muscle + @@ -63963,8 +93850,15 @@ + The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. vesicle fusion with vacuole + + + + The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. + GOC:ai + @@ -63989,8 +93883,15 @@ + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. regulation of cytoskeleton organization + + + + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. + GOC:ai + @@ -64016,8 +93917,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. negative regulation of cytoskeleton organization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. + GOC:ai + @@ -64043,8 +93951,15 @@ + Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. positive regulation of cytoskeleton organization + + + + Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. + GOC:ai + @@ -64052,8 +93967,18 @@ + The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. detection of stimulus + + + + The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. + GOC:add + GOC:ai + GOC:dph + GOC:mah + @@ -64081,8 +94006,15 @@ + The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. norepinephrine uptake + + + + The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. + GOC:ai + @@ -64107,8 +94039,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. regulation of norepinephrine uptake + + + + Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. + GOC:ai + @@ -64134,8 +94073,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. negative regulation of norepinephrine uptake + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. + GOC:ai + @@ -64161,8 +94107,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell. positive regulation of norepinephrine uptake + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell. + GOC:ai + @@ -64199,8 +94152,15 @@ + Any process in which an organelle is transported to, and/or maintained in, a specific location. organelle localization + + + + Any process in which an organelle is transported to, and/or maintained in, a specific location. + GOC:ai + @@ -64209,8 +94169,17 @@ + A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular localization + + + + A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. + GOC:tb + GOC:vw + @@ -64235,8 +94204,15 @@ + Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. Golgi localization + + + + Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. + GOC:ai + @@ -64261,8 +94237,15 @@ + Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. nucleus localization + + + + Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. + GOC:ai + @@ -64287,8 +94270,15 @@ + Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. vesicle localization + + + + Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. + GOC:ai + @@ -64331,8 +94321,18 @@ + Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. establishment of localization in cell + + + + Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. + GOC:ai + GOC:dos + GOC:dph + GOC:tb + @@ -64353,8 +94353,15 @@ + The directed movement of a vesicle to a specific location. establishment of vesicle localization + + + + The directed movement of a vesicle to a specific location. + GOC:ai + @@ -64374,8 +94381,15 @@ + The directed movement of an organelle to a specific location. establishment of organelle localization + + + + The directed movement of an organelle to a specific location. + GOC:ai + @@ -64400,8 +94414,15 @@ + Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. localization within membrane + + + + Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. + GOC:ai + @@ -64427,8 +94448,15 @@ + Any process in which a cell is transported to, and/or maintained in, a specific location. localization of cell + + + + Any process in which a cell is transported to, and/or maintained in, a specific location. + GOC:ai + @@ -64449,8 +94477,15 @@ + The directed movement of the Golgi to a specific location. establishment of Golgi localization + + + + The directed movement of the Golgi to a specific location. + GOC:ai + @@ -64459,8 +94494,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. response to other organism + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. + GOC:ai + @@ -64469,8 +94511,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular response to stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. + GOC:bf + GOC:jl + @@ -64495,8 +94546,17 @@ + Any process that modulates the rate or extent of progression through the cell cycle. regulation of cell cycle + + + + Any process that modulates the rate or extent of progression through the cell cycle. + GOC:ai + GOC:dph + GOC:tb + @@ -64522,8 +94582,15 @@ + Any process that activates or increases the frequency, rate or extent of cell division. positive regulation of cell division + + + + Any process that activates or increases the frequency, rate or extent of cell division. + GOC:ai + @@ -64549,8 +94616,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. negative regulation of cell division + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. + GOC:ai + @@ -64575,8 +94649,15 @@ + Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. regulation of nuclear division + + + + Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + GOC:ai + @@ -64602,8 +94683,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. negative regulation of nuclear division + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + GOC:ai + @@ -64629,8 +94717,15 @@ + Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. positive regulation of nuclear division + + + + Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + GOC:ai + @@ -64661,8 +94756,15 @@ + Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. pigment granule localization + + + + Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. + GOC:ai + @@ -64688,8 +94790,15 @@ + Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. regulation of cardioblast differentiation + + + + Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. + GOC:ai + @@ -64716,8 +94825,15 @@ + Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. positive regulation of cardioblast differentiation + + + + Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. + GOC:ai + @@ -64744,8 +94860,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. negative regulation of cardioblast differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. + GOC:ai + @@ -64766,8 +94889,15 @@ + The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. pigment granule transport + + + + The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -64781,8 +94911,15 @@ + The directed movement of a pigment granule to a specific location. establishment of pigment granule localization + + + + The directed movement of a pigment granule to a specific location. + GOC:ai + @@ -64807,8 +94944,15 @@ + Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. regulation of sensory perception of pain + + + + Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. + GOC:ai + @@ -64833,8 +94977,15 @@ + Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. regulation of sensory perception + + + + Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. + GOC:ai + @@ -64859,8 +95010,16 @@ + The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. catecholamine transport + + + + The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:ai + ISBN:0198506732 + @@ -64885,8 +95044,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of amine transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -64912,8 +95078,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of amine transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -64939,8 +95112,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of amine transport + + + + Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -64977,8 +95157,15 @@ + Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. regulation of nervous system development + + + + Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai + @@ -65005,8 +95192,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. negative regulation of nervous system development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai + @@ -65033,8 +95227,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. positive regulation of nervous system development + + + + Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai + @@ -65059,8 +95260,16 @@ + Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. regulation of synapse assembly + + + + Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. + GOC:ai + GOC:pr + @@ -65087,8 +95296,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. negative regulation of synapse assembly + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. + GOC:ai + GOC:pr + @@ -65115,8 +95332,16 @@ + Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. positive regulation of synapse assembly + + + + Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. + GOC:ai + GOC:pr + @@ -65142,8 +95367,15 @@ + Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. regulation of transmission of nerve impulse + + + + Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. + GOC:ai + @@ -65170,8 +95402,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. negative regulation of transmission of nerve impulse + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. + GOC:ai + @@ -65198,8 +95437,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. positive regulation of transmission of nerve impulse + + + + Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. + GOC:ai + @@ -65224,8 +95470,15 @@ + Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. regulation of chromosome segregation + + + + Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. + GOC:ai + @@ -65251,8 +95504,15 @@ + Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. positive regulation of chromosome segregation + + + + Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. + GOC:ai + @@ -65278,8 +95538,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. negative regulation of chromosome segregation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. + GOC:ai + @@ -65310,8 +95577,16 @@ + The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. muscle cell development + + + + The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. + CL:0000187 + GOC:devbiol + @@ -65342,8 +95617,16 @@ + The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. striated muscle cell development + + + + The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. + CL:0000737 + GOC:devbiol + @@ -65374,8 +95657,15 @@ + The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. cardiac myofibril assembly + + + + The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. + GOC:devbiol + @@ -65406,8 +95696,15 @@ + The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. cardiac cell development + + + + The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. + GOC:devbiol + @@ -65439,8 +95736,16 @@ + The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. cardiac muscle cell differentiation + + + + The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. + GOC:devbiol + GOC:mtg_heart + @@ -65477,8 +95782,15 @@ + The process in which the anatomical structures of cardiac muscle tissue are generated and organized. cardiac muscle tissue morphogenesis + + + + The process in which the anatomical structures of cardiac muscle tissue are generated and organized. + GOC:devbiol + @@ -65515,8 +95827,15 @@ + The process in which the anatomical structure of cardiac atrium muscle is generated and organized. atrial cardiac muscle tissue morphogenesis + + + + The process in which the anatomical structure of cardiac atrium muscle is generated and organized. + GOC:devbiol + @@ -65553,8 +95872,15 @@ + The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. ventricular cardiac muscle tissue morphogenesis + + + + The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. + GOC:devbiol + @@ -65586,8 +95912,16 @@ + The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. cardiac muscle cell development + + + + The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. + GOC:devbiol + GOC:mtg_heart + @@ -65624,8 +95958,15 @@ + The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. cardiac muscle tissue growth + + + + The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. + GOC:devbiol + @@ -65651,8 +95992,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. regulation of cardiac muscle fiber development + + + + Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. + GOC:vk + @@ -65679,8 +96027,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development. negative regulation of cardiac muscle fiber development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development. + GOC:vk + @@ -65707,8 +96062,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development. positive regulation of cardiac muscle fiber development + + + + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development. + GOC:vk + @@ -65733,8 +96095,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle growth. regulation of cardiac muscle tissue growth + + + + Any process that modulates the frequency, rate or extent of cardiac muscle growth. + GOC:vk + @@ -65760,8 +96129,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. negative regulation of cardiac muscle tissue growth + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. + GOC:vk + @@ -65787,8 +96163,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth. positive regulation of cardiac muscle tissue growth + + + + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth. + GOC:vk + @@ -65813,8 +96196,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. regulation of cardiac muscle tissue development + + + + Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. + GOC:vk + @@ -65840,8 +96230,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. positive regulation of cardiac muscle tissue development + + + + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. + GOC:vk + @@ -65867,8 +96264,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. negative regulation of cardiac muscle tissue development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. + GOC:vk + @@ -65899,8 +96303,16 @@ + The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. neuroblast division + + + + The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. + PMID:11163136 + PMID:11250167 + @@ -65921,8 +96333,44 @@ + The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. asymmetric neuroblast division + + + + The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. + GOC:dph + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell. + intracellular chemical homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell. + GOC:isa_complete + GOC:jid + @@ -65948,8 +96396,51 @@ + The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. + Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. transmembrane transport + + + + The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. + GOC:dph + GOC:jid + + + + + + + + + + + + + + + + + + + + + + + + + + Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. + lipid homeostasis + + + + + Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. + GOC:BHF + GOC:rl + @@ -65974,8 +96465,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. response to lipoprotein particle + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. + GOC:BHF + GOC:rl + @@ -66020,8 +96519,15 @@ + The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex. Golgi to secretory granule transport + + + + The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex. + GOC:curators + @@ -66072,8 +96578,15 @@ + The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Golgi to transport vesicle transport + + + + The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. + GOC:jid + @@ -66099,8 +96612,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle contraction. regulation of cardiac muscle contraction + + + + Any process that modulates the frequency, rate or extent of cardiac muscle contraction. + GOC:ecd + @@ -66127,8 +96647,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. negative regulation of cardiac muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. + GOC:ecd + @@ -66153,8 +96680,49 @@ + The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. digestive system development + + + + The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:jid + + + + + + + + + + + + + + + + + + + + + + + + + + The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. + roof of mouth development + + + + + The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. + GOC:dph + ISBN:0721662544 + @@ -66185,8 +96753,15 @@ + The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. pharyngeal system development + + + + The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. + GOC:dph + @@ -66217,8 +96792,17 @@ + The expansion of a cardiac muscle cell population by cell division. cardiac muscle cell proliferation + + + + The expansion of a cardiac muscle cell population by cell division. + GOC:dph + GOC:rph + PMID:11161571 + @@ -66249,8 +96833,18 @@ + The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. pericardium development + + + + The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. + GOC:dph + GOC:rph + PMID:15138308 + PMID:16376438 + @@ -66285,8 +96879,17 @@ + The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. retina development in camera-type eye + + + + The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + GOC:bf + GOC:dph + ISBN:0815340729 + @@ -66323,8 +96926,17 @@ + The process in which the anatomical structure of the retina is generated and organized. retina morphogenesis in camera-type eye + + + + The process in which the anatomical structure of the retina is generated and organized. + GOC:bf + GOC:dph + GOC:mtg_sensu + @@ -66350,8 +96962,16 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. regulation of cardiac muscle cell proliferation + + + + Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. + GOC:dph + GOC:rph + @@ -66378,8 +96998,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. negative regulation of cardiac muscle cell proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. + GOC:dph + GOC:rph + @@ -66406,8 +97034,16 @@ + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. positive regulation of cardiac muscle cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. + GOC:dph + GOC:rph + @@ -66421,8 +97057,15 @@ + The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. heart contraction + + + + The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. + GOC:dph + @@ -66453,8 +97096,15 @@ + Muscle contraction of cardiac muscle tissue. cardiac muscle contraction + + + + Muscle contraction of cardiac muscle tissue. + GOC:dph + @@ -66489,8 +97139,15 @@ + A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. embryonic process involved in female pregnancy + + + + A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. + GOC:dph + @@ -66516,8 +97173,15 @@ + Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. regulation of syncytium formation by plasma membrane fusion + + + + Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. + GOC:dph + @@ -66544,8 +97208,15 @@ + Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. positive regulation of syncytium formation by plasma membrane fusion + + + + Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. + GOC:dph + @@ -66577,8 +97248,18 @@ + The portion of the plasma membrane surrounding a cilium. + Note that cilia and eukaryotic flagella are deemed to be equivalent. ciliary membrane + + + + The portion of the plasma membrane surrounding a cilium. + GOC:cilia + GOC:dph + GOC:rph + @@ -66603,8 +97284,18 @@ + The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. + Wikipedia:Limb_development limb development + + + + The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. + GOC:dgh + GOC:dph + PMID:11487378 + @@ -66635,8 +97326,17 @@ + Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. endocardium formation + + + + Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:bf + GOC:dph + PMID:17722983 + @@ -66662,8 +97362,19 @@ + The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. hematopoietic stem cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + GOC:BHF + GOC:bf + GOC:dph + GOC:rl + PMID:15378083 + @@ -66700,8 +97411,17 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. camera-type eye photoreceptor cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -66726,8 +97446,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell. retinal rod cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell. + GOC:dph + @@ -66756,8 +97483,17 @@ + A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. mesenchymal to epithelial transition + + + + A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -66765,8 +97501,15 @@ + A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. anatomical structure homeostasis + + + + A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GOC:dph + @@ -66791,8 +97534,16 @@ + Any process that modulates the frequency, rate or extent of glial cell proliferation. regulation of glial cell proliferation + + + + Any process that modulates the frequency, rate or extent of glial cell proliferation. + GOC:dph + GOC:tb + @@ -66819,8 +97570,17 @@ + Any process that activates or increases the rate or extent of glial cell proliferation. positive regulation of glial cell proliferation + + + + Any process that activates or increases the rate or extent of glial cell proliferation. + GOC:dph + GOC:sl + GOC:tb + @@ -66847,8 +97607,17 @@ + Any process that stops or decreases the rate or extent of glial cell proliferation. negative regulation of glial cell proliferation + + + + Any process that stops or decreases the rate or extent of glial cell proliferation. + GOC:dph + GOC:sl + GOC:tb + @@ -66873,8 +97642,16 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. regulation of macromolecule metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -67104,8 +97881,24 @@ + The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + Note that we deem cilium and microtubule-based flagellum to be equivalent. cilium assembly + + + + The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + GOC:BHF + GOC:cilia + GOC:dph + GOC:kmv + GOC:pr + GOC:vw + ISBN:0198506732 + PMID:13978319 + PMID:27350441 + @@ -67130,8 +97923,17 @@ + Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. regulation of oocyte development + + + + Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:dph + GOC:tb + PMID:2394318 + @@ -67158,8 +97960,16 @@ + Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. positive regulation of oocyte development + + + + Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:dph + GOC:tb + @@ -67186,8 +97996,16 @@ + Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. negative regulation of oocyte development + + + + Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:dph + GOC:tb + @@ -67212,8 +98030,16 @@ + Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. regulation of cell development + + + + Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + GOC:dph + GOC:tb + @@ -67227,8 +98053,21 @@ + Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent. cilium-dependent cell motility + + + + Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + GOC:cilia + GOC:dgh + GOC:dph + GOC:krc + GOC:mlg + GOC:mtg_cambridge_2013 + @@ -67253,8 +98092,17 @@ + Movement of cilia mediated by motor proteins that contributes to the movement of a cell. cilium movement involved in cell motility + + + + Movement of cilia mediated by motor proteins that contributes to the movement of a cell. + GOC:BHF + GOC:dph + GOC:tb + @@ -67280,8 +98128,17 @@ + Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility. regulation of cilium movement involved in cell motility + + + + Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility. + GOC:BHF + GOC:dph + GOC:tb + @@ -67307,8 +98164,17 @@ + Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. regulation of sarcomere organization + + + + Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + GOC:BHF + GOC:dph + GOC:tb + @@ -67336,8 +98202,17 @@ + Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. positive regulation of sarcomere organization + + + + Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + GOC:BHF + GOC:dph + GOC:tb + @@ -67366,8 +98241,17 @@ + Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. negative regulation of sarcomere organization + + + + Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + GOC:BHF + GOC:dph + GOC:tb + @@ -67392,8 +98276,15 @@ + The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. head development + + + + The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. + GOC:dph + @@ -67430,8 +98321,15 @@ + The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. head morphogenesis + + + + The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. + GOC:dph + @@ -67462,8 +98360,15 @@ + The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. face development + + + + The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. + GOC:dph + @@ -67500,8 +98405,15 @@ + The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. face morphogenesis + + + + The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. + GOC:dph + @@ -67533,8 +98445,15 @@ + The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). cell chemotaxis + + + + The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). + GOC:dph + @@ -67560,8 +98479,184 @@ + Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. regulation of cellular localization + + + + Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + trabecula formation + + + + + The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod. + liver trabecula formation + + + + + The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod. + spleen trabecula formation + + + + + The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. + heart trabecula formation + + + + + The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. + GOC:dph + @@ -67592,8 +98687,15 @@ + The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. bone development + + + + The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. + GOC:dph + @@ -67630,8 +98732,15 @@ + The process in which bones are generated and organized. bone morphogenesis + + + + The process in which bones are generated and organized. + GOC:dph + @@ -67656,8 +98765,16 @@ + The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. endochondral bone morphogenesis + + + + The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. + GOC:dph + PMID:11680679 + @@ -67682,8 +98799,15 @@ + The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. cartilage development involved in endochondral bone morphogenesis + + + + The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. + GOC:dph + @@ -67708,8 +98832,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. response to ammonium ion + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:23509267 + @@ -67735,8 +98868,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. cardiac muscle cell myoblast differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. + GOC:dph + GOC:tb + @@ -67762,8 +98903,18 @@ + The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules. axonemal microtubule depolymerization + + + + The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules. + GOC:cilia + GOC:dph + GOC:krc + GOC:tb + @@ -67800,8 +98951,16 @@ + The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. cardiac septum morphogenesis + + + + The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. + GOC:dph + GOC:mtg_heart + @@ -67832,8 +98991,15 @@ + The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. ventricular septum morphogenesis + + + + The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. + GOC:dph + @@ -67870,8 +99036,16 @@ + The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. atrial septum morphogenesis + + + + The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. + GOC:dph + GOC:mtg_heart + @@ -67908,8 +99082,18 @@ + The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. aorta smooth muscle tissue morphogenesis + + + + The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. + GOC:bf + GOC:dgh + GOC:dph + Wikipedia:Aorta + @@ -67940,8 +99124,15 @@ + The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. muscle tissue morphogenesis + + + + The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. + GOC:dph + @@ -67972,8 +99163,16 @@ + The increase in size or mass of the heart. heart growth + + + + The increase in size or mass of the heart. + GOC:dph + GOC:tb + @@ -67999,8 +99198,16 @@ + Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. regulation of heart growth + + + + Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. + GOC:dph + GOC:tb + @@ -68026,8 +99233,17 @@ + Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. positive regulation of heart growth + + + + Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. + GOC:BHF + GOC:dph + GOC:tb + @@ -68058,8 +99274,15 @@ + The process in which the anatomical structures of the lung are generated and organized. lung morphogenesis + + + + The process in which the anatomical structures of the lung are generated and organized. + GOC:dph + @@ -68090,8 +99313,16 @@ + The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs. lung vasculature development + + + + The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs. + GOC:dph + GOC:mtg_lung + @@ -68122,8 +99353,16 @@ + The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs. lung connective tissue development + + + + The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs. + GOC:dph + GOC:mtg_lung + @@ -68154,8 +99393,16 @@ + The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. lung epithelium development + + + + The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. + GOC:dph + GOC:mtg_lung + @@ -68180,8 +99427,16 @@ + The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. epithelium development + + + + The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. + GOC:dph + GOC:mtg_lung + @@ -68209,8 +99464,16 @@ + The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds. primary lung bud formation + + + + The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds. + GOC:dph + GOC:mtg_lung + @@ -68241,8 +99504,15 @@ + The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs. bronchus development + + + + The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs. + GOC:dph + @@ -68274,8 +99544,15 @@ + The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs. bronchus morphogenesis + + + + The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs. + GOC:dph + @@ -68306,8 +99583,16 @@ + The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. bronchiole development + + + + The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. + GOC:dph + GOC:mtg_lung + @@ -68338,8 +99623,15 @@ + The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. bronchiole morphogenesis + + + + The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. + GOC:dph + @@ -68370,8 +99662,15 @@ + The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. lung growth + + + + The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. + GOC:dph + @@ -68402,8 +99701,15 @@ + The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. trachea development + + + + The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. + GOC:dph + @@ -68434,8 +99740,15 @@ + The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. trachea morphogenesis + + + + The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. + GOC:dph + @@ -68466,8 +99779,15 @@ + The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches. trachea formation + + + + The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches. + GOC:dph + @@ -68492,8 +99812,88 @@ + The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. epithelial tube branching involved in lung morphogenesis + + + + The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. + GOC:dph + GOC:mtg_lung + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + positive regulation of hindgut contraction + + + + + Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + negative regulation of hindgut contraction + + + + + Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + GOC:dph + GOC:tb + @@ -68520,8 +99920,16 @@ + Any process that increases the frequency, rate or extent of cardiac muscle contraction. positive regulation of cardiac muscle contraction + + + + Any process that increases the frequency, rate or extent of cardiac muscle contraction. + GOC:dph + GOC:tb + @@ -68547,8 +99955,16 @@ + Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. regulation of gastric acid secretion + + + + Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb + @@ -68575,8 +99991,16 @@ + Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. positive regulation of gastric acid secretion + + + + Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb + @@ -68603,8 +100027,16 @@ + Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. negative regulation of gastric acid secretion + + + + Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb + @@ -68630,8 +100062,16 @@ + Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. positive regulation of digestive system process + + + + Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:dph + GOC:tb + @@ -68657,8 +100097,16 @@ + Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. negative regulation of digestive system process + + + + Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:dph + GOC:tb + @@ -68683,8 +100131,16 @@ + The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect. right lung development + + + + The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect. + GOC:dph + GOC:mtg_lung + @@ -68709,8 +100165,16 @@ + The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect. left lung development + + + + The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect. + GOC:dph + GOC:mtg_lung + @@ -68741,8 +100205,15 @@ + The process in which anatomical structures of the left lung are generated and organized. left lung morphogenesis + + + + The process in which anatomical structures of the left lung are generated and organized. + GOC:dph + @@ -68773,8 +100244,16 @@ + The process in which anatomical structures of the right lung are generated and organized. right lung morphogenesis + + + + The process in which anatomical structures of the right lung are generated and organized. + GOC:dph + GOC:mtg_lung + @@ -68805,8 +100284,15 @@ + The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung. lung lobe development + + + + The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung. + GOC:dph + @@ -68843,8 +100329,15 @@ + The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung. lung lobe morphogenesis + + + + The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung. + GOC:dph + @@ -68875,8 +100368,15 @@ + The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung. lung lobe formation + + + + The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung. + GOC:dph + @@ -68907,8 +100407,16 @@ + The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth. pharynx development + + + + The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth. + GOC:dph + GOC:rk + @@ -68934,8 +100442,15 @@ + Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). negative regulation of fertilization + + + + Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). + GOC:dph + @@ -68960,8 +100475,15 @@ + The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg. prevention of polyspermy + + + + The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg. + GOC:dph + @@ -68975,8 +100497,16 @@ + The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. lung cell differentiation + + + + The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:dph + GOC:mtg_lung + @@ -69007,8 +100537,15 @@ + The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. mesenchyme development + + + + The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. + GOC:dph + @@ -69033,8 +100570,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles. club cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles. + GOC:dph + GOC:mtg_lung + PMID:28144783 + @@ -69066,8 +100612,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. lung epithelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. + GOC:dph + @@ -69093,8 +100646,16 @@ + Any process that modulates the rate, frequency, or extent of cell projection assembly. regulation of cell projection assembly + + + + Any process that modulates the rate, frequency, or extent of cell projection assembly. + GOC:dph + GOC:tb + @@ -69119,8 +100680,16 @@ + Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure. cell-cell signaling involved in lung development + + + + Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure. + GOC:dph + GOC:mtg_lung + @@ -69140,8 +100709,16 @@ + Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung. mesenchymal-epithelial cell signaling involved in lung development + + + + Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung. + GOC:dph + GOC:mtg_lung + @@ -69176,8 +100753,15 @@ + Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell. mesenchymal-endodermal cell signaling + + + + Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell. + GOC:dph + @@ -69203,8 +100787,15 @@ + Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. positive regulation of epithelial cell proliferation involved in lung morphogenesis + + + + Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. + GOC:dph + @@ -69235,8 +100826,15 @@ + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. epithelial cell proliferation involved in lung morphogenesis + + + + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. + GOC:dph + @@ -69261,8 +100859,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles. type I pneumocyte differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles. + GOC:dph + GOC:mtg_lung + ISBN:0721662544 + @@ -69287,8 +100894,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies. type II pneumocyte differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies. + GOC:dph + GOC:mtg_lung + ISBN:0721662544 + @@ -69319,8 +100935,16 @@ + The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. bronchus cartilage development + + + + The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + GOC:mtg_lung + @@ -69357,8 +100981,15 @@ + The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs. bronchus cartilage morphogenesis + + + + The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs. + GOC:dph + @@ -69389,8 +101020,15 @@ + The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. trachea cartilage development + + + + The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + @@ -69427,8 +101065,15 @@ + The process in which the anatomical structures of cartilage in the trachea are generated and organized. trachea cartilage morphogenesis + + + + The process in which the anatomical structures of cartilage in the trachea are generated and organized. + GOC:dph + @@ -69460,8 +101105,15 @@ + The process in which the anatomical structures of cartilage are generated and organized. cartilage morphogenesis + + + + The process in which the anatomical structures of cartilage are generated and organized. + GOC:dph + @@ -69486,8 +101138,15 @@ + The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. muscle tissue development + + + + The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. + GOC:dph + @@ -69512,8 +101171,15 @@ + The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. skeletal muscle organ development + + + + The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. + GOC:dph + @@ -69570,8 +101236,15 @@ + The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs. diaphragm development + + + + The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs. + GOC:dph + @@ -69628,8 +101301,15 @@ + The process in which the anatomical structures of the diaphragm are generated and organized. diaphragm morphogenesis + + + + The process in which the anatomical structures of the diaphragm are generated and organized. + GOC:dph + @@ -69654,8 +101334,15 @@ + The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. respiratory system development + + + + The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. + GOC:dph + @@ -69680,8 +101367,15 @@ + The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. developmental growth involved in morphogenesis + + + + The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. + GOC:dph + @@ -69706,8 +101400,16 @@ + Any apoptotic process that contributes to the shaping of an anatomical structure. apoptotic process involved in morphogenesis + + + + Any apoptotic process that contributes to the shaping of an anatomical structure. + GOC:dph + GOC:mtg_apoptosis + @@ -69733,8 +101435,15 @@ + The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. epithelial tube morphogenesis + + + + The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + GOC:dph + @@ -69759,8 +101468,16 @@ + The process in which epiblast cells acquire specialized features of neuroepithelial cells. neuroepithelial cell differentiation + + + + The process in which epiblast cells acquire specialized features of neuroepithelial cells. + GOC:dph + GOC:tb + @@ -69785,8 +101502,15 @@ + The morphogenetic process in which an epithelial sheet bends along a linear axis. morphogenesis of an epithelial fold + + + + The morphogenetic process in which an epithelial sheet bends along a linear axis. + GOC:dph + @@ -69811,8 +101535,133 @@ + The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding. morphogenesis of an epithelial bud + + + + The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. + intestinal epithelial cell maturation + + + + + The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. + GOC:dph + PMID:18824147 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. + intestinal epithelial cell differentiation + + + + + The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. + intestinal epithelial cell development + + + + + The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. + GOC:dph + @@ -69837,8 +101686,15 @@ + The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart. pulmonary vein morphogenesis + + + + The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart. + GOC:dph + @@ -69863,8 +101719,15 @@ + The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart. superior vena cava morphogenesis + + + + The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart. + GOC:dph + @@ -69889,8 +101752,15 @@ + The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type. cell fate commitment involved in pattern specification + + + + The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type. + GOC:dph + @@ -69921,8 +101791,15 @@ + The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes. chondroblast differentiation + + + + The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes. + GOC:dph + @@ -69953,8 +101830,15 @@ + The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. adipose tissue development + + + + The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. + GOC:dph + @@ -69979,8 +101863,16 @@ + Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. regulation of chromosome condensation + + + + Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. + GOC:dph + GOC:tb + @@ -70006,8 +101898,16 @@ + Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. regulation of vesicle-mediated transport + + + + Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. + GOC:dph + GOC:tb + @@ -70032,8 +101932,16 @@ + Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. regulation of microtubule-based movement + + + + Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. + GOC:dph + GOC:tb + @@ -70068,8 +101976,15 @@ + Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted. mesenchymal-epithelial cell signaling + + + + Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted. + GOC:dph + @@ -70104,8 +102019,15 @@ + Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted. epithelial-mesenchymal cell signaling + + + + Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted. + GOC:dph + @@ -70131,8 +102053,15 @@ + Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. regulation of morphogenesis of a branching structure + + + + Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. + GOC:dph + @@ -70157,8 +102086,15 @@ + Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue. regulation of cell proliferation involved in tissue homeostasis + + + + Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue. + GOC:dph + @@ -70183,8 +102119,15 @@ + Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue. regulation of apoptosis involved in tissue homeostasis + + + + Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue. + GOC:dph + @@ -70209,8 +102152,15 @@ + Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue. regulation of cell differentiation involved in tissue homeostasis + + + + Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue. + GOC:dph + @@ -70241,8 +102191,17 @@ + The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. ectodermal placode formation + + + + The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70267,8 +102226,17 @@ + The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. cell fate commitment involved in formation of primary germ layer + + + + The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70299,8 +102267,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. blood vessel endothelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70325,8 +102302,17 @@ + The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. artery development + + + + The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70351,8 +102337,17 @@ + The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. venous blood vessel development + + + + The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70377,8 +102372,17 @@ + The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries. arterial endothelial cell differentiation + + + + The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70403,8 +102407,17 @@ + The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins. venous endothelial cell differentiation + + + + The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70412,8 +102425,17 @@ + The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate. neural plate pattern specification + + + + The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70422,8 +102444,17 @@ + The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. neural plate regionalization + + + + The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70437,8 +102468,17 @@ + The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. embryonic camera-type eye formation + + + + The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70464,8 +102504,16 @@ + Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. positive regulation of macrophage cytokine production + + + + Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:dph + GOC:tb + @@ -70496,8 +102544,15 @@ + The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. heart formation + + + + The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. + GOC:mtg_heart + @@ -70522,8 +102577,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. mesenchymal cell differentiation involved in lung development + + + + The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. + GOC:dph + @@ -70548,8 +102610,15 @@ + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. mesenchymal cell proliferation involved in lung development + + + + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:dph + @@ -70574,8 +102643,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. cardiac pacemaker cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_heart + @@ -70606,8 +102683,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node. sinoatrial node cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node. + GOC:mtg_heart + @@ -70639,8 +102723,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node. atrioventricular node cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node. + GOC:mtg_heart + @@ -70671,8 +102762,16 @@ + The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. cardiac pacemaker cell development + + + + The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_heart + @@ -70703,8 +102802,15 @@ + The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state. atrioventricular node cell development + + + + The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state. + GOC:mtg_heart + @@ -70735,8 +102841,15 @@ + The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. sinoatrial node cell development + + + + The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. + GOC:mtg_heart + @@ -70767,8 +102880,15 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles. His-Purkinje system cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles. + GOC:mtg_heart + @@ -70799,8 +102919,15 @@ + The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. His-Purkinje system cell development + + + + The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. + GOC:mtg_heart + @@ -70825,8 +102952,15 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. cardiac fibroblast cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. + GOC:mtg_heart + @@ -70857,8 +102991,15 @@ + The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. cardiac fibroblast cell development + + + + The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. + GOC:mtg_heart + @@ -70890,8 +103031,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart. cardiac neuron differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart. + GOC:mtg_heart + @@ -70917,8 +103065,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels. cardiac blood vessel endothelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels. + GOC:mtg_heart + @@ -70944,8 +103099,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart. cardiac glial cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart. + GOC:mtg_heart + @@ -70977,8 +103139,15 @@ + The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell. cardiac glial cell development + + + + The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell. + GOC:mtg_heart + @@ -71009,8 +103178,15 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. endocardial cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:mtg_heart + @@ -71042,8 +103218,15 @@ + The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. endocardial cell development + + + + The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. + GOC:mtg_heart + @@ -71075,8 +103258,15 @@ + The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state. cardiac neuron development + + + + The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state. + GOC:mtg_heart + @@ -71101,8 +103291,15 @@ + The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. cell migration involved in heart development + + + + The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. + GOC:mtg_heart + @@ -71127,8 +103324,15 @@ + The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells. cell migration involved in heart formation + + + + The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells. + GOC:mtg_heart + @@ -71159,8 +103363,15 @@ + The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. coronary vasculature development + + + + The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. + GOC:mtg_heart + @@ -71191,8 +103402,15 @@ + The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. coronary vasculature morphogenesis + + + + The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. + GOC:mtg_heart + @@ -71217,8 +103435,15 @@ + Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels. angiogenesis involved in coronary vascular morphogenesis + + + + Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels. + GOC:mtg_heart + @@ -71243,8 +103468,15 @@ + The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes. vasculogenesis involved in coronary vascular morphogenesis + + + + The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes. + GOC:mtg_heart + @@ -71270,8 +103502,15 @@ + The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart. cell migration involved in coronary vasculogenesis + + + + The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart. + GOC:mtg_heart + @@ -71296,8 +103535,15 @@ + The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels. cell migration involved in coronary angiogenesis + + + + The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels. + GOC:mtg_heart + @@ -71311,8 +103557,217 @@ + The regulated release of a hormone into the circulatory system. endocrine hormone secretion + + + + The regulated release of a hormone into the circulatory system. + GOC:dph + + + + + + + + + An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + hepaticobiliary system process + + + + + An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + hepaticobiliary system development + + + + + The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine. + common bile duct development + + + + + The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine. + PMID:20614624 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile. + gallbladder development + + + + + The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct. + hepatic duct development + + + + + The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct. + GOC:dph + PMID:20614624 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes. + hepatoblast differentiation + + + + + The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes. + GOC:dph + PMID:15226394 + @@ -71337,8 +103792,16 @@ + A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. membrane organization + + + + A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. + GOC:dph + GOC:tb + @@ -71363,8 +103826,17 @@ + The membrane organization process that joins two lipid bilayers to form a single membrane. + Wikipedia:Lipid_bilayer_fusion membrane fusion + + + + The membrane organization process that joins two lipid bilayers to form a single membrane. + GOC:dph + GOC:tb + @@ -71395,8 +103867,16 @@ + The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium. visceral serous pericardium development + + + + The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium. + GOC:dph + GOC:yaf + @@ -71421,8 +103901,15 @@ + Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. regulation of cartilage development + + + + Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + @@ -71449,8 +103936,15 @@ + Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. positive regulation of cartilage development + + + + Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + @@ -71477,8 +103971,15 @@ + Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. negative regulation of cartilage development + + + + Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + @@ -71509,8 +104010,16 @@ + The process in which a female gonad is generated and organized. female gonad morphogenesis + + + + The process in which a female gonad is generated and organized. + GOC:BHF + GOC:dph + @@ -71536,8 +104045,16 @@ + Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. regulation of branching involved in lung morphogenesis + + + + Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. + GOC:dph + GOC:yaf + @@ -71564,8 +104081,16 @@ + Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. positive regulation of branching involved in lung morphogenesis + + + + Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. + GOC:dph + GOC:yaf + @@ -71592,8 +104117,16 @@ + Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. negative regulation of branching involved in lung morphogenesis + + + + Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. + GOC:dph + GOC:yaf + @@ -71624,8 +104157,15 @@ + The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. cell growth involved in cardiac muscle cell development + + + + The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. + GOC:dph + @@ -71651,8 +104191,15 @@ + Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. regulation of cell growth involved in cardiac muscle cell development + + + + Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. + GOC:dph + @@ -71681,8 +104228,15 @@ + Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. positive regulation of cell growth involved in cardiac muscle cell development + + + + Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. + GOC:dph + @@ -71711,8 +104265,15 @@ + Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. negative regulation of cell growth involved in cardiac muscle cell development + + + + Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. + GOC:dph + @@ -71743,8 +104304,15 @@ + The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. somite development + + + + The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. + GOC:dph + @@ -71775,8 +104343,15 @@ + The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. dermatome development + + + + The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. + GOC:dph + @@ -71807,8 +104382,15 @@ + The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle. myotome development + + + + The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle. + GOC:dph + @@ -71839,8 +104421,15 @@ + The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. sclerotome development + + + + The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. + GOC:dph + @@ -71877,8 +104466,15 @@ + The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. muscle structure development + + + + The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. + GOC:dph + @@ -71909,8 +104505,15 @@ + The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina. iris morphogenesis + + + + The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina. + GOC:dph + @@ -71941,8 +104544,15 @@ + The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes. ciliary body morphogenesis + + + + The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes. + GOC:dph + @@ -71967,8 +104577,15 @@ + Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. regulation of neural retina development + + + + Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. + GOC:dph + @@ -71994,8 +104611,15 @@ + Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. positive regulation of neural retina development + + + + Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. + GOC:dph + @@ -72021,8 +104645,15 @@ + Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. negative regulation of neural retina development + + + + Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. + GOC:dph + @@ -72053,8 +104684,15 @@ + The progression of the right horn of the sinus venosus from its formation to the mature structure. right horn of sinus venosus development + + + + The progression of the right horn of the sinus venosus from its formation to the mature structure. + GOC:dph + @@ -72079,8 +104717,16 @@ + Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. positive regulation of myeloid leukocyte cytokine production involved in immune response + + + + Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. + GOC:BHF + GOC:dph + @@ -72088,8 +104734,16 @@ + Any process that contributes to cytokine production by a myeloid cell. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. myeloid leukocyte cytokine production + + + + Any process that contributes to cytokine production by a myeloid cell. + GOC:dph + @@ -72115,8 +104769,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. lung neuroendocrine cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. + GOC:dph + PMID:9126746 + @@ -72142,8 +104804,15 @@ + The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. neuroendocrine cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. + GOC:dph + @@ -72175,8 +104844,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium. stomach neuroendocrine cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium. + GOC:dph + PMID:18173746 + @@ -72202,8 +104879,15 @@ + Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. regulation of stomach neuroendocrine cell differentiation + + + + Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. + GOC:dph + @@ -72230,8 +104914,15 @@ + Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. negative regulation of stomach neuroendocrine cell differentiation + + + + Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. + GOC:dph + @@ -72256,8 +104947,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells. dense core granule organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells. + GOC:dph + @@ -72277,8 +104975,87 @@ + Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ. epithelial-mesenchymal cell signaling involved in lung development + + + + Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized. + pancreas morphogenesis + + + + + Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the branches of the pancreas are generated and organized. + branching involved in pancreas morphogenesis + + + + + The process in which the branches of the pancreas are generated and organized. + GOC:dph + @@ -72304,8 +105081,51 @@ + Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. negative regulation of heart growth + + + + Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. + GOC:dph + GOC:hjd + + + + + + + + + + + + + + + + + + + + + + + + + + + + The morphogenetic process in which the foregut region specified to become the pancreas forms a bud. + pancreatic bud formation + + + + + The morphogenetic process in which the foregut region specified to become the pancreas forms a bud. + GOC:dph + @@ -72314,8 +105134,15 @@ + The process in which the anatomical structures of a branched epithelium are generated and organized. morphogenesis of a branching epithelium + + + + The process in which the anatomical structures of a branched epithelium are generated and organized. + GOC:dph + @@ -72340,8 +105167,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part. lung secretory cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part. + GOC:dph + @@ -72366,8 +105200,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells. lung ciliated cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells. + GOC:cilia + GOC:dph + GOC:krc + @@ -72398,8 +105241,15 @@ + The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. endocardial endothelium development + + + + The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:dph + @@ -72424,8 +105274,15 @@ + A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. extracellular matrix organization involved in endocardium development + + + + A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:dph + @@ -72456,8 +105313,55 @@ + The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea. trachea submucosa development + + + + The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea. + GOC:dph + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection. + trachea gland development + + + + + The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection. + GOC:dph + @@ -72483,8 +105387,16 @@ + The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. endothelial tube morphogenesis + + + + The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. + GOC:dph + GOC:yaf + @@ -72515,8 +105427,16 @@ + The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery. pulmonary artery endothelial tube morphogenesis + + + + The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery. + GOC:dph + GOC:yaf + @@ -72541,8 +105461,86 @@ + The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs. pulmonary artery morphogenesis + + + + The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs. + GOC:dph + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + regulation of insulin secretion involved in cellular response to glucose stimulus + + + + + Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + GOC:BHF + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + negative regulation of insulin secretion involved in cellular response to glucose stimulus + + + + + Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + GOC:BHF + GOC:dph + @@ -72568,8 +105566,16 @@ + Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. regulation of chondrocyte development + + + + Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + GOC:BHF + GOC:dph + @@ -72596,8 +105602,16 @@ + Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. negative regulation of chondrocyte development + + + + Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + GOC:BHF + GOC:dph + @@ -72622,8 +105636,16 @@ + Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. regulation of dermatome development + + + + Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. + GOC:BHF + GOC:dph + @@ -72649,8 +105671,16 @@ + Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. positive regulation of dermatome development + + + + Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. + GOC:BHF + GOC:dph + @@ -72676,8 +105706,16 @@ + Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. negative regulation of dermatome development + + + + Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. + GOC:BHF + GOC:dph + @@ -72703,8 +105741,16 @@ + Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. positive regulation of sclerotome development + + + + Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. + GOC:BHF + GOC:dph + @@ -72729,8 +105775,15 @@ + Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. regulation of sclerotome development + + + + Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. + GOC:dph + @@ -72761,8 +105814,16 @@ + The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. retina vasculature development in camera-type eye + + + + The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. + GOC:BHF + GOC:dph + @@ -72793,8 +105854,16 @@ + The process in which the vasculature of the retina is generated and organized. retina vasculature morphogenesis in camera-type eye + + + + The process in which the vasculature of the retina is generated and organized. + GOC:BHF + GOC:dph + @@ -72825,8 +105894,15 @@ + The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. cornea development in camera-type eye + + + + The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. + GOC:dph + @@ -72852,8 +105928,16 @@ + The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. retinal blood vessel morphogenesis + + + + The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. + GOC:BHF + GOC:dph + @@ -72873,8 +105957,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches. cardiac neural crest cell differentiation involved in heart development + + + + The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches. + GOC:dph + GOC:mtg_heart + PMID:19705442 + @@ -72899,8 +105992,16 @@ + The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart. cardiac neural crest cell development involved in heart development + + + + The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart. + GOC:dph + GOC:mtg_heart + @@ -72925,8 +106026,16 @@ + The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract. cardiac neural crest cell development involved in outflow tract morphogenesis + + + + The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract. + GOC:dph + GOC:mtg_heart + @@ -72951,8 +106060,16 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart. cell proliferation involved in heart morphogenesis + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart. + GOC:dph + GOC:mtg_heart + @@ -72977,8 +106094,16 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract. cell proliferation involved in outflow tract morphogenesis + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract. + GOC:dph + GOC:mtg_heart + @@ -72986,8 +106111,15 @@ + Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. cardiac conduction + + + + Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. + GOC:dph + @@ -73012,8 +106144,17 @@ + The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart. cell adhesion involved in heart morphogenesis + + + + The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart. + GOC:dph + GOC:mtg_heart + PMID:16860783 + @@ -73038,8 +106179,17 @@ + Any process that modulates the extent of cell adhesion contributing to the shaping of the heart. regulation of cell adhesion involved in heart morphogenesis + + + + Any process that modulates the extent of cell adhesion contributing to the shaping of the heart. + GOC:dph + GOC:mtg_heart + PMID:16860783 + @@ -73047,8 +106197,82 @@ + The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. neural precursor cell proliferation + + + + The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. + GOC:dph + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + trabecula morphogenesis + + + + + The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + heart trabecula morphogenesis + + + + + The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + GOC:dph + @@ -73068,8 +106292,15 @@ + The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart. fibroblast proliferation involved in heart morphogenesis + + + + The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart. + GOC:dph + @@ -73094,8 +106325,15 @@ + The progression of a connective tissue over time, from its formation to the mature structure. connective tissue development + + + + The progression of a connective tissue over time, from its formation to the mature structure. + GOC:BHF + @@ -73126,8 +106364,49 @@ + Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst. trophoblast cell migration + + + + Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction. + interstitial cell of Cajal differentiation + + + + + The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction. + GOC:dph + @@ -73152,8 +106431,15 @@ + The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. reproductive system development + + + + The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. + GOC:dph + @@ -73178,8 +106464,48 @@ + A process in which a protein is transported to, or maintained in, a location within a lysosome. protein localization to lysosome + + + + A process in which a protein is transported to, or maintained in, a location within a lysosome. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation. + regulation of type B pancreatic cell proliferation + + + + + Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation. + GOC:dph + @@ -73204,8 +106530,16 @@ + Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. hematopoietic stem cell homeostasis + + + + Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. + GOC:dph + PMID:21508411 + @@ -73398,8 +106732,15 @@ + A process in which a protein is transported to, or maintained in, a location within a cilium. protein localization to cilium + + + + A process in which a protein is transported to, or maintained in, a location within a cilium. + GOC:dph + @@ -73430,8 +106771,15 @@ + The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. myeloid cell development + + + + The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. + GOC:dph + @@ -73457,8 +106805,16 @@ + The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. macrophage homeostasis + + + + The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. + GOC:dph + PMID:21727904 + @@ -73483,8 +106839,52 @@ + A cellular process that results in the breakdown of a cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. cilium disassembly + + + + A cellular process that results in the breakdown of a cilium. + GOC:cilia + GOC:dph + PMID:17604723 + PMID:27350441 + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut. + hindgut development + + + + + The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut. + GOC:dph + @@ -73515,8 +106915,15 @@ + The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. ganglion development + + + + The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. + GOC:dph + @@ -73547,8 +106954,16 @@ + The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. sympathetic ganglion development + + + + The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. + GOC:BHF + GOC:rl + @@ -73579,8 +106994,15 @@ + The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. cranial ganglion development + + + + The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. + GOC:dph + @@ -73605,8 +107027,15 @@ + The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure. trigeminal ganglion development + + + + The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure. + GOC:dph + @@ -73637,8 +107066,15 @@ + The process in which the anatomical structures of ganglion are generated and organized. ganglion morphogenesis + + + + The process in which the anatomical structures of ganglion are generated and organized. + GOC:dph + @@ -73669,8 +107105,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state. ganglion maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state. + GOC:dph + @@ -73701,8 +107144,15 @@ + The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts. ganglion formation + + + + The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts. + GOC:dph + @@ -73739,8 +107189,15 @@ + The process in which the anatomical structure of a trigeminal ganglion is generated and organized. trigeminal ganglion morphogenesis + + + + The process in which the anatomical structure of a trigeminal ganglion is generated and organized. + GOC:dph + @@ -73777,8 +107234,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state. trigeminal ganglion maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state. + GOC:dph + @@ -73815,8 +107279,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state. cranial ganglion maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state. + GOC:dph + @@ -73853,8 +107324,15 @@ + The process in which the anatomical structure of a cranial ganglion is generated and organized. cranial ganglion morphogenesis + + + + The process in which the anatomical structure of a cranial ganglion is generated and organized. + GOC:dph + @@ -73885,8 +107363,15 @@ + The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts. cranial ganglion formation + + + + The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts. + GOC:dph + @@ -73917,8 +107402,15 @@ + The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts. trigeminal ganglion formation + + + + The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts. + GOC:dph + @@ -73943,8 +107435,48 @@ + A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. actin filament bundle organization + + + + A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism. + colon epithelial cell migration + + + + + The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism. + GOC:dph + @@ -73969,8 +107501,48 @@ + The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism. corneal epithelial cell migration + + + + The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism. + intestinal epithelial cell migration + + + + + The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism. + GOC:dph + @@ -74001,8 +107573,17 @@ + The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. pharyngeal arch artery morphogenesis + + + + The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. + GOC:BHF + GOC:dph + PMID:20122914 + @@ -74028,8 +107609,18 @@ + Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling. secretory granule maturation + + + + Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling. + GOC:PARL + GOC:bf + GOC:dph + PMID:16618809 + @@ -74054,8 +107645,15 @@ + Any process that modulates the frequency, rate or extent of neuroblast migration. regulation of neuroblast migration + + + + Any process that modulates the frequency, rate or extent of neuroblast migration. + PMID:23149556 + @@ -74081,8 +107679,15 @@ + Any process that activates or increases the frequency, rate or extent of neuroblast migration. positive regulation of neuroblast migration + + + + Any process that activates or increases the frequency, rate or extent of neuroblast migration. + PMID:23149556 + @@ -74108,8 +107713,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration. negative regulation of neuroblast migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration. + PMID:23149556 + @@ -74140,8 +107752,17 @@ + A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. glial cell activation + + + + A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + GOC:aruk + GOC:bc + PMID:18723082 + @@ -74166,8 +107787,15 @@ + A process in which a protein is transported to or maintained in a location within the somatodendritic compartment. protein localization to somatodendritic compartment + + + + A process in which a protein is transported to or maintained in a location within the somatodendritic compartment. + PMID:18341993 + @@ -74191,8 +107819,16 @@ + The directed movement of a protein to a specific location in a plasma membrane. establishment of protein localization to plasma membrane + + + + The directed movement of a protein to a specific location in a plasma membrane. + GOC:dph + GOC:vw + @@ -74217,8 +107853,15 @@ + The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone. replacement bone morphogenesis + + + + The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone. + PMID:29852585 + @@ -74243,8 +107886,16 @@ + The process in which bone which forms superficially in the organism are generated and organized. dermal bone morphogenesis + + + + The process in which bone which forms superficially in the organism are generated and organized. + PMID:12588850 + PMID:15003632 + @@ -74269,8 +107920,116 @@ + The process in which bone which forms deep in the organism are generated and organized. membrane bone morphogenesis + + + + The process in which bone which forms deep in the organism are generated and organized. + PMID:14579374 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the rate, frequency or extent of a small molecule metabolic process. + regulation of small molecule metabolic process + + + + + Any process that modulates the rate, frequency or extent of a small molecule metabolic process. + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. + positive regulation of small molecule metabolic process + + + + + Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. + negative regulation of small molecule metabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. + GOC:vw + @@ -74290,8 +108049,17 @@ + An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. collagen-containing extracellular matrix + + + + An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. + GOC:BHF + GOC:rph + PMID:21123617 + @@ -74318,8 +108086,15 @@ + Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis. positive regulation of mitotic sister chromatid segregation + + + + Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis. + PMID:12773390 + @@ -74350,8 +108125,15 @@ + The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. stomach development + + + + The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. + PMID:11967278 + @@ -74376,8 +108158,15 @@ + The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. detection of stimulus involved in sensory perception of pain + + + + The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. + PMID:19837031 + @@ -74402,8 +108191,15 @@ + Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell. protein localization to postsynapse + + + + Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell. + PMID:31189538 + @@ -74431,8 +108227,16 @@ + The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. + Note that this term is not intended for use in annotating lateral movement within membranes. intracellular protein transmembrane transport + + + + The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. + GOC:isa_complete + @@ -74458,8 +108262,15 @@ + The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. protein-containing complex assembly + + + + The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. + GOC:jl + @@ -74485,8 +108296,15 @@ + The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. protein-DNA complex assembly + + + + The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. + GOC:jl + @@ -74494,8 +108312,52 @@ + Any process that modulates a measurable attribute of any biological process, quality or function. biological regulation + + + + Any process that modulates a measurable attribute of any biological process, quality or function. + GOC:dph + GOC:isa_complete + GOC:mah + GOC:pr + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + regulation of molecular function + + + + + Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GOC:isa_complete + @@ -74515,8 +108377,15 @@ + Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. extracellular membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. + GOC:isa_complete + @@ -74541,8 +108410,15 @@ + An organelle lumen that is part of an intracellular organelle. intracellular organelle lumen + + + + An organelle lumen that is part of an intracellular organelle. + GOC:mah + @@ -74567,8 +108443,16 @@ + The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. neuron cellular homeostasis + + + + The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. + GOC:BHF + GOC:mah + @@ -74582,8 +108466,23 @@ + A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. extracellular exosome + + + + A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. + GOC:BHF + GOC:mah + GOC:vesicles + PMID:15908444 + PMID:17641064 + PMID:19442504 + PMID:19498381 + PMID:22418571 + PMID:24009894 + @@ -74608,8 +108507,16 @@ + The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). glucagon secretion + + + + The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). + GOC:BHF + GOC:rl + @@ -74634,8 +108541,16 @@ + Any process that modulates the frequency, rate or extent of the regulated release of glucagon. regulation of glucagon secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah + @@ -74661,8 +108576,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. negative regulation of glucagon secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah + @@ -74688,8 +108611,16 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. positive regulation of glucagon secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah + @@ -74697,8 +108628,15 @@ + A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. anchoring junction + + + + A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. + ISBN:0815332181 + @@ -74718,8 +108656,15 @@ + A process of chromosome organization that is involved in a meiotic cell cycle. chromosome organization involved in meiotic cell cycle + + + + A process of chromosome organization that is involved in a meiotic cell cycle. + GOC:mah + @@ -74739,8 +108684,16 @@ + The directed movement of a protein to a specific location on a chromosome. establishment of protein localization to chromosome + + + + The directed movement of a protein to a specific location on a chromosome. + GOC:BHF + GOC:mah + @@ -74765,8 +108718,16 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. regulation of establishment of protein localization + + + + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. + GOC:BHF + GOC:mah + @@ -74791,8 +108752,16 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. regulation of establishment of protein localization to chromosome + + + + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. + GOC:BHF + GOC:mah + @@ -74817,8 +108786,19 @@ + Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). lymphocyte apoptotic process + + + + Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + CL:0000542 + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74843,8 +108823,18 @@ + Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). regulation of lymphocyte apoptotic process + + + + Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74870,8 +108860,18 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). negative regulation of lymphocyte apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74897,8 +108897,18 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). positive regulation of lymphocyte apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74923,8 +108933,18 @@ + Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. T cell apoptotic process + + + + Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. + CL:0000084 + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74949,8 +108969,17 @@ + Any process that modulates the occurrence or rate of T cell death by apoptotic process. regulation of T cell apoptotic process + + + + Any process that modulates the occurrence or rate of T cell death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74976,8 +109005,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. negative regulation of T cell apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -75003,8 +109041,17 @@ + Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. positive regulation of T cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -75029,8 +109076,156 @@ + The regulated release of somatostatin from secretory granules in the D cells of the pancreas. somatostatin secretion + + + + The regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. + mucus secretion + + + + + The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. + GOC:add + ISBN:068340007X + ISBN:0721662544 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + regulation of mucus secretion + + + + + Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + negative regulation of mucus secretion + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + positive regulation of mucus secretion + + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + @@ -75061,8 +109256,15 @@ + The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate. pigment cell development + + + + The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate. + GOC:cvs + @@ -75087,8 +109289,16 @@ + The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. fat cell proliferation + + + + The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. + GOC:mah + GOC:sl + @@ -75113,8 +109323,16 @@ + Any process that modulates the frequency, rate or extent of fat cell proliferation. regulation of fat cell proliferation + + + + Any process that modulates the frequency, rate or extent of fat cell proliferation. + GOC:mah + GOC:sl + @@ -75140,8 +109358,16 @@ + Any process that stops or decreases the rate or extent of fat cell proliferation. negative regulation of fat cell proliferation + + + + Any process that stops or decreases the rate or extent of fat cell proliferation. + GOC:mah + GOC:sl + @@ -75167,8 +109393,162 @@ + Any process that activates or increases the rate or extent of fat cell proliferation. positive regulation of fat cell proliferation + + + + Any process that activates or increases the rate or extent of fat cell proliferation. + GOC:mah + GOC:sl + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. + hepatocyte differentiation + + + + + The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. + CL:0000182 + PMID:7588884 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of hepatocyte differentiation. + regulation of hepatocyte differentiation + + + + + Any process that modulates the frequency, rate or extent of hepatocyte differentiation. + GOC:mah + GOC:sl + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or decreases the rate or extent of hepatocyte differentiation. + negative regulation of hepatocyte differentiation + + + + + Any process that stops or decreases the rate or extent of hepatocyte differentiation. + GOC:mah + GOC:sl + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the rate or extent of hepatocyte differentiation. + positive regulation of hepatocyte differentiation + + + + + Any process that activates or increases the rate or extent of hepatocyte differentiation. + GOC:mah + GOC:sl + @@ -75188,8 +109568,16 @@ + A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. exocytic vesicle + + + + A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. + GOC:kad + GOC:mah + @@ -75197,8 +109585,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. response to oxygen levels + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. + GOC:BHF + GOC:mah + @@ -75207,8 +109603,16 @@ + The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. detection of hypoxia + + + + The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. + GOC:BHF + GOC:mah + @@ -75234,8 +109638,15 @@ + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. regulation of microtubule cytoskeleton organization + + + + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. + GOC:mah + @@ -75260,8 +109671,17 @@ + The directed movement of a substance from one side of an epithelium to the other. transepithelial transport + + + + The directed movement of a substance from one side of an epithelium to the other. + GOC:mah + GOC:yaf + ISBN:0716731363 + @@ -75286,8 +109706,16 @@ + The directed movement of ammonium ions from one side of an epithelium to the other. transepithelial ammonium transport + + + + The directed movement of ammonium ions from one side of an epithelium to the other. + GOC:mah + GOC:yaf + @@ -75324,8 +109752,15 @@ + The expansion of a leukocyte population by cell division. leukocyte proliferation + + + + The expansion of a leukocyte population by cell division. + GOC:add + @@ -75350,8 +109785,16 @@ + Any process that modulates the frequency, rate or extent of leukocyte proliferation. regulation of leukocyte proliferation + + + + Any process that modulates the frequency, rate or extent of leukocyte proliferation. + GOC:add + GOC:mah + @@ -75377,8 +109820,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. negative regulation of leukocyte proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. + GOC:add + GOC:mah + @@ -75404,8 +109855,16 @@ + Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. positive regulation of leukocyte proliferation + + + + Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. + GOC:add + GOC:mah + @@ -75414,8 +109873,15 @@ + Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. cellular macromolecule localization + + + + Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. + GOC:mah + @@ -75440,8 +109906,233 @@ + The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. + Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer. basement membrane assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + regulation of bile acid biosynthetic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + negative regulation of bile acid biosynthetic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + positive regulation of bile acid biosynthetic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + regulation of glycogen metabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + negative regulation of glycogen metabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + positive regulation of glycogen metabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah + @@ -75450,8 +110141,16 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular response to chemical stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + GOC:mah + @@ -75476,8 +110175,15 @@ + The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. organelle assembly + + + + The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + GOC:mah + @@ -75508,8 +110214,16 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. bone maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. + GOC:dph + GOC:mah + @@ -75534,8 +110248,15 @@ + Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. protein localization to chromatin + + + + Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. + GOC:mah + @@ -75555,8 +110276,15 @@ + The directed movement of a protein to a part of a chromosome that is organized into chromatin. establishment of protein localization to chromatin + + + + The directed movement of a protein to a part of a chromosome that is organized into chromatin. + GOC:mah + @@ -75576,8 +110304,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. cellular response to ammonium ion + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:23509267 + @@ -75597,8 +110334,72 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. cellular response to carbohydrate stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. + GOC:mah + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. + cellular response to hexose stimulus + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. + cellular response to glucose stimulus + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. + GOC:mah + @@ -75618,8 +110419,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. cellular response to peptide hormone stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. + GOC:mah + @@ -75639,8 +110447,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. cellular response to glucagon stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. + GOC:mah + @@ -75660,8 +110475,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. cellular response to steroid hormone stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. + GOC:mah + @@ -75681,8 +110503,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. cellular response to lipid + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. + GOC:mah + @@ -75703,8 +110532,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. cellular response to organonitrogen compound + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. + GOC:mah + @@ -75724,8 +110560,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. cellular response to amine stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. + GOC:mah + @@ -75756,8 +110599,19 @@ + The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. hematopoietic stem cell proliferation + + + + The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. + CL:0000037 + GOC:BHF + GOC:add + GOC:mah + GOC:rl + @@ -75765,8 +110619,16 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular response to endogenous stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. + GOC:mah + @@ -75786,8 +110648,15 @@ + The movement of a granulocyte in response to an external stimulus. granulocyte chemotaxis + + + + The movement of a granulocyte in response to an external stimulus. + GOC:rph + @@ -75812,8 +110681,15 @@ + Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. regulation of granulocyte chemotaxis + + + + Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. + GOC:mah + @@ -75839,8 +110715,15 @@ + Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. negative regulation of granulocyte chemotaxis + + + + Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. + GOC:mah + @@ -75866,8 +110749,15 @@ + Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. positive regulation of granulocyte chemotaxis + + + + Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. + GOC:mah + @@ -75875,8 +110765,15 @@ + The process of biting and mashing food with the teeth prior to swallowing. mastication + + + + The process of biting and mashing food with the teeth prior to swallowing. + GOC:gvg + @@ -75896,8 +110793,15 @@ + The directed movement of a smooth muscle cell in response to an external stimulus. smooth muscle cell chemotaxis + + + + The directed movement of a smooth muscle cell in response to an external stimulus. + GOC:mah + @@ -75923,8 +110827,15 @@ + Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis. regulation of smooth muscle cell chemotaxis + + + + Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis. + GOC:mah + @@ -75951,8 +110862,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis. negative regulation of smooth muscle cell chemotaxis + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis. + GOC:mah + @@ -75979,8 +110897,15 @@ + Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis. positive regulation of smooth muscle cell chemotaxis + + + + Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis. + GOC:mah + @@ -76005,8 +110930,15 @@ + The movement of a mononuclear cell within or between different tissues and organs of the body. mononuclear cell migration + + + + The movement of a mononuclear cell within or between different tissues and organs of the body. + GOC:mah + @@ -76031,8 +110963,15 @@ + Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. regulation of mononuclear cell migration + + + + Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. + GOC:mah + @@ -76058,8 +110997,15 @@ + Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. negative regulation of mononuclear cell migration + + + + Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. + GOC:mah + @@ -76085,8 +111031,15 @@ + Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. positive regulation of mononuclear cell migration + + + + Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. + GOC:mah + @@ -76111,8 +111064,15 @@ + Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. protein localization to extracellular region + + + + Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. + GOC:mah + @@ -76143,8 +111103,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. anatomical structure maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. + GOC:mah + @@ -76169,8 +111136,15 @@ + The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. ectodermal placode development + + + + The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. + GOC:mah + @@ -76201,8 +111175,15 @@ + The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. ectodermal placode morphogenesis + + + + The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. + GOC:mah + @@ -76227,8 +111208,15 @@ + The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. nitrogen compound transport + + + + The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -76260,8 +111248,15 @@ + The aggregation, arrangement and bonding together of a set of components to form a membrane. membrane assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a membrane. + GOC:mah + @@ -76286,8 +111281,16 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. + Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer. basement membrane organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. + GOC:mah + @@ -76318,8 +111321,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. nuclear membrane organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. + GOC:mah + @@ -76344,8 +111354,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane. nuclear outer membrane organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane. + GOC:mah + @@ -76369,8 +111386,17 @@ + The process in which a protein is transported across a membrane. + Note that this term is not intended for use in annotating lateral movement within membranes. protein transmembrane transport + + + + The process in which a protein is transported across a membrane. + GOC:mah + GOC:vw + @@ -76395,8 +111421,15 @@ + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. protein-DNA complex organization + + + + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. + GOC:mah + @@ -76421,8 +111454,15 @@ + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. protein-RNA complex organization + + + + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. + GOC:mah + @@ -76430,8 +111470,16 @@ + A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular component organization or biogenesis + + + + A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. + GOC:mah + @@ -76456,8 +111504,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. response to catecholamine + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. + GOC:BHF + GOC:mah + @@ -76477,8 +111533,16 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. cellular response to catecholamine stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. + GOC:BHF + GOC:mah + @@ -76503,8 +111567,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. + Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. response to norepinephrine + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. + GOC:BHF + GOC:mah + @@ -76524,8 +111597,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. + Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. cellular response to norepinephrine stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. + GOC:BHF + GOC:mah + @@ -76562,8 +111644,19 @@ + Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). leukocyte apoptotic process + + + + Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + CL:0000738 + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + @@ -76590,8 +111683,19 @@ + Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). macrophage apoptotic process + + + + Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues. + CL:0000235 + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + @@ -76616,8 +111720,15 @@ + The biosynthetic process resulting in the formation of DNA. DNA biosynthetic process + + + + The biosynthetic process resulting in the formation of DNA. + GOC:mah + @@ -76625,8 +111736,15 @@ + The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. cell periphery + + + + The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. + GOC:pdt + @@ -76640,8 +111758,17 @@ + An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. elastic fiber + + + + An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. + GOC:BHF + GOC:mah + PMID:20236620 + @@ -76672,8 +111799,53 @@ + The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. extracellular exosome assembly + + + + The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. + GOC:mah + GOC:tfm + PMID:19442504 + PMID:27462458 + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels. + renal system development + + + + + The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels. + GOC:mtg_kidney_jan10 + GOC:yaf + PMID:6996269 + @@ -76704,8 +111876,15 @@ + The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. stem cell proliferation + + + + The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + GOC:mtg_kidney_jan10 + @@ -76730,8 +111909,15 @@ + Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. regulation of stem cell proliferation + + + + Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + GOC:mtg_kidney_jan10 + @@ -76768,8 +111954,15 @@ + The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. mesenchyme morphogenesis + + + + The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. + GOC:mtg_kidney_jan10 + @@ -76800,8 +111993,15 @@ + The developmental process pertaining to the initial formation of an epithelial tube. epithelial tube formation + + + + The developmental process pertaining to the initial formation of an epithelial tube. + GOC:mtg_kidney_jan10 + @@ -76827,8 +112027,82 @@ + Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. negative regulation of mesenchymal cell proliferation + + + + Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:mtg_kidney_jan10 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + monocarboxylic acid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + monocarboxylic acid biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + GOC:mah + @@ -76853,8 +112127,16 @@ + The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. circulatory system development + + + + The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. + GOC:mah + UBERON:0001009 + @@ -76885,8 +112167,17 @@ + The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis. vascular cord development + + + + The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis. + GOC:mah + PMID:7084422 + ZFA:0005077 + @@ -76910,8 +112201,15 @@ + The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. organelle transport along microtubule + + + + The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. + GOC:mah + @@ -76940,8 +112238,16 @@ + The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. + Note that this term is not intended for use in annotating lateral movement within membranes. ammonium transmembrane transport + + + + The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. + GOC:mah + @@ -76966,8 +112272,131 @@ + A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. fibroblast activation + + + + A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. + CL:0000057 + GOC:BHF + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + These processes continue to 60 DPA in Gossypium spp. + type B pancreatic cell maturation + + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + CL:0000169 + GOC:BHF + + + + + + + + + + + + + + + + + + + + + + + + + + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver. + epithelial cell proliferation involved in liver morphogenesis + + + + + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver. + GOC:BHF + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the anatomical structures of the liver are generated and organized. + liver morphogenesis + + + + + The process in which the anatomical structures of the liver are generated and organized. + GOC:mah + @@ -76992,8 +112421,18 @@ + Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. endothelial cell apoptotic process + + + + Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. + CL:0000115 + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + @@ -77018,8 +112457,15 @@ + The chemical reactions and pathways involving diatomic oxygen (O2). oxygen metabolic process + + + + The chemical reactions and pathways involving diatomic oxygen (O2). + GOC:mah + @@ -77039,8 +112485,15 @@ + The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. establishment of protein localization to organelle + + + + The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. + GOC:mah + @@ -77060,8 +112513,15 @@ + A process in which a protein is transported to, or maintained in, a specific location in a membrane. protein localization to membrane + + + + A process in which a protein is transported to, or maintained in, a specific location in a membrane. + GOC:mah + @@ -77096,8 +112556,15 @@ + A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. protein localization to plasma membrane + + + + A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. + GOC:mah + @@ -77122,8 +112589,15 @@ + A process in which a protein is transported to, or maintained at, a location in a vacuole. protein localization to vacuole + + + + A process in which a protein is transported to, or maintained at, a location in a vacuole. + GOC:ecd + @@ -77143,8 +112617,15 @@ + The directed movement of a protein to a specific location in a vacuole. establishment of protein localization to vacuole + + + + The directed movement of a protein to a specific location in a vacuole. + GOC:mah + @@ -77169,8 +112650,17 @@ + The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. multinuclear osteoclast differentiation + + + + The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. + CL:0000779 + GOC:mah + PMID:12713016 + @@ -77195,8 +112685,17 @@ + The movement of a lymphocyte within or between different tissues and organs of the body. lymphocyte migration + + + + The movement of a lymphocyte within or between different tissues and organs of the body. + CL:0000542 + GOC:BHF + GOC:mah + @@ -77221,8 +112720,17 @@ + The movement of a T cell within or between different tissues and organs of the body. T cell migration + + + + The movement of a T cell within or between different tissues and organs of the body. + CL:0000084 + GOC:BHF + GOC:mah + @@ -77247,8 +112755,15 @@ + A process in which a protein is transported to, or maintained in, the cell cortex. protein localization to cell cortex + + + + A process in which a protein is transported to, or maintained in, the cell cortex. + GOC:mah + @@ -77273,8 +112788,15 @@ + A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. protein localization to microtubule cytoskeleton + + + + A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. + GOC:mah + @@ -77299,8 +112821,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. regulation of primary metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + PMID:19211694 + @@ -77325,8 +112854,16 @@ + Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of response to stress + + + + Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + GOC:dhl + @@ -77351,8 +112888,16 @@ + Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). regulation of fertilization + + + + Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). + GOC:DHL + PMID:20478994 + @@ -77377,8 +112922,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. lytic vacuole organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. + PMID:20729380 + @@ -77404,8 +112956,15 @@ + The aggregation, arrangement and bonding together of the extracellular matrix. extracellular matrix assembly + + + + The aggregation, arrangement and bonding together of the extracellular matrix. + GOC:jl + @@ -77430,8 +112989,16 @@ + An action potential that occurs in a cardiac muscle cell. cardiac muscle cell action potential + + + + An action potential that occurs in a cardiac muscle cell. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77462,8 +113029,16 @@ + An action potential that occurs in a sinoatrial node cardiac muscle cell. SA node cell action potential + + + + An action potential that occurs in a sinoatrial node cardiac muscle cell. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77494,8 +113069,16 @@ + An action potential that occurs in an atrioventricular node cardiac muscle cell. AV node cell action potential + + + + An action potential that occurs in an atrioventricular node cardiac muscle cell. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77526,8 +113109,16 @@ + An action potential that occurs in a Purkinje myocyte. Purkinje myocyte action potential + + + + An action potential that occurs in a Purkinje myocyte. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77536,8 +113127,16 @@ + Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. SA node cell to atrial cardiac muscle cell signaling + + + + Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77557,8 +113156,16 @@ + Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. cell-cell signaling involved in cardiac conduction + + + + Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77567,8 +113174,16 @@ + Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. AV node cell to bundle of His cell signaling + + + + Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77604,8 +113219,16 @@ + Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell. Purkinje myocyte to ventricular cardiac muscle cell signaling + + + + Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77630,8 +113253,16 @@ + Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. cell communication involved in cardiac conduction + + + + Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77639,8 +113270,16 @@ + The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. AV node cell to bundle of His cell communication + + + + The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77648,8 +113287,16 @@ + The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Purkinje myocyte to ventricular cardiac muscle cell communication + + + + The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77657,8 +113304,16 @@ + The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. SA node cell to atrial cardiac muscle cell communication + + + + The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77684,8 +113339,16 @@ + Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. regulation of monocyte chemotaxis + + + + Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. + GOC:dph + GOC:tb + @@ -77712,8 +113375,16 @@ + Any process that increases the frequency, rate, or extent of monocyte chemotaxis. positive regulation of monocyte chemotaxis + + + + Any process that increases the frequency, rate, or extent of monocyte chemotaxis. + GOC:dph + GOC:tb + @@ -77740,8 +113411,16 @@ + Any process that decreases the frequency, rate, or extent of monocyte chemotaxis. negative regulation of monocyte chemotaxis + + + + Any process that decreases the frequency, rate, or extent of monocyte chemotaxis. + GOC:dph + GOC:tb + @@ -77767,8 +113446,16 @@ + Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. positive regulation of microtubule nucleation + + + + Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. + GOC:dph + GOC:tb + @@ -77794,8 +113481,16 @@ + Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. positive regulation of cell cycle process + + + + Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + GOC:dph + GOC:tb + @@ -77820,8 +113515,16 @@ + Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. regulation of ribosome biogenesis + + + + Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. + GOC:dph + GOC:tb + @@ -77847,8 +113550,16 @@ + Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. positive regulation of ribosome biogenesis + + + + Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. + GOC:dph + GOC:tb + @@ -77874,8 +113585,16 @@ + Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. negative regulation of ribosome biogenesis + + + + Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. + GOC:dph + GOC:tb + @@ -77900,8 +113619,16 @@ + Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of peptide transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:dph + GOC:tb + @@ -77927,8 +113654,16 @@ + Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. positive regulation of extracellular matrix disassembly + + + + Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. + GOC:dph + GOC:tb + @@ -77936,8 +113671,17 @@ + The process in which the population of cells that make up a tissue undergo directed movement. tissue migration + + + + The process in which the population of cells that make up a tissue undergo directed movement. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -77945,8 +113689,17 @@ + The process in which the population of cells that make up an epithelium undergo directed movement. epithelium migration + + + + The process in which the population of cells that make up an epithelium undergo directed movement. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -77966,8 +113719,17 @@ + Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. regulation of actin cytoskeleton organization by cell-cell adhesion + + + + Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -77987,8 +113749,17 @@ + The directed movement of a protein to a specific location in a membrane. establishment of protein localization to membrane + + + + The directed movement of a protein to a specific location in a membrane. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78013,8 +113784,17 @@ + The specification and formation of anisotropic intracellular organization of an epithelial cell. establishment of epithelial cell polarity + + + + The specification and formation of anisotropic intracellular organization of an epithelial cell. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78046,8 +113826,17 @@ + A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance. Golgi disassembly + + + + A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78062,8 +113851,17 @@ + The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. Golgi reassembly + + + + The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78088,8 +113886,17 @@ + Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division. regulation of Golgi inheritance + + + + Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78120,8 +113927,17 @@ + The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte. chondrocyte morphogenesis + + + + The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78147,8 +113963,17 @@ + The joining of two lipid bilayers to form a single organelle membrane. organelle membrane fusion + + + + The joining of two lipid bilayers to form a single organelle membrane. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78173,8 +113998,16 @@ + Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. regulation of muscle system process + + + + Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. + GOC:dph + GOC:tb + @@ -78199,8 +114032,15 @@ + Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. regulation of somatostatin secretion + + + + Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF + @@ -78226,8 +114066,15 @@ + Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. positive regulation of somatostatin secretion + + + + Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF + @@ -78253,8 +114100,15 @@ + Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. negative regulation of somatostatin secretion + + + + Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF + @@ -78280,8 +114134,15 @@ + Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. regulation of peptide hormone secretion + + + + Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb + @@ -78308,8 +114169,15 @@ + Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. positive regulation of peptide hormone secretion + + + + Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb + @@ -78336,8 +114204,15 @@ + Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. negative regulation of peptide hormone secretion + + + + Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb + @@ -78362,8 +114237,15 @@ + Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. regulation of osteoclast proliferation + + + + Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. + GOC:tb + @@ -78389,8 +114271,15 @@ + Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. positive regulation of osteoclast proliferation + + + + Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. + GOC:tb + @@ -78416,8 +114305,15 @@ + Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. negative regulation of osteoclast proliferation + + + + Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. + GOC:tb + @@ -78443,8 +114339,15 @@ + Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. regulation of neural crest formation + + + + Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. + GOC:tb + @@ -78470,8 +114373,15 @@ + Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. positive regulation of neural crest formation + + + + Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. + GOC:tb + @@ -78497,8 +114407,15 @@ + Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. negative regulation of neural crest formation + + + + Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. + GOC:tb + @@ -78525,8 +114442,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. positive regulation of intracellular protein transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. + GOC:tb + @@ -78553,8 +114477,159 @@ + Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. negative regulation of intracellular protein transport + + + + Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + regulation of locomotion involved in locomotory behavior + + + + + Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + positive regulation of locomotion involved in locomotory behavior + + + + + Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + negative regulation of locomotion involved in locomotory behavior + + + + + Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. + acinar cell differentiation + + + + + The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. + GOC:dph + GOC:tb + @@ -78579,8 +114654,15 @@ + A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. protein localization to nuclear envelope + + + + A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. + GOC:tb + @@ -78619,8 +114701,16 @@ + The directed movement of catecholamine into a cell. catecholamine uptake + + + + The directed movement of catecholamine into a cell. + GOC:dph + GOC:tb + @@ -78645,8 +114735,16 @@ + The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism. mesenchymal cell migration + + + + The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism. + GOC:dph + GOC:tb + @@ -78677,8 +114775,16 @@ + Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. sensory organ morphogenesis + + + + Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:kmv + ISBN:978-0199210893 + @@ -78703,8 +114809,16 @@ + A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus. RNA localization to nucleus + + + + A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus. + GOC:mah + PMID:26305931 + @@ -78729,8 +114843,15 @@ + Any membrane that is part of a pigment granule. pigment granule membrane + + + + Any membrane that is part of a pigment granule. + PMID:11294610 + @@ -78755,8 +114876,19 @@ + All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". ciliary plasm + + + + All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. + GOC:BHF + GOC:cilia + GOC:dos + PMID:17895364 + @@ -78781,8 +114913,18 @@ + Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. + Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals. dendritic cell dendrite assembly + + + + Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. + CL:0000451 + GOC:BHF + PMID:12200351 + @@ -78807,8 +114949,17 @@ + The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. + Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. dendritic cell differentiation + + + + The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. + CL:0000451 + GOC:pr + @@ -78833,8 +114984,18 @@ + Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. dendritic cell apoptotic process + + + + Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. + CL:0000451 + GOC:BHF + GOC:mtg_apoptosis + PMID:15059845 + @@ -78859,8 +115020,54 @@ + Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. motor neuron apoptotic process + + + + Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. + CL:0000100 + GOC:BHF + GOC:mtg_apoptosis + PMID:14523086 + + + + + + + + + + + + + + + + + + + + + + + + + + Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. + type B pancreatic cell apoptotic process + + + + + Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. + CL:0000169 + GOC:BHF + GOC:mtg_apoptosis + PMID:16087305 + @@ -78885,8 +115092,16 @@ + A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. synaptic membrane + + + + A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. + GOC:BHF + PMID:20410104 + @@ -78917,8 +115132,15 @@ + The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. vascular associated smooth muscle cell development + + + + The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. + GOC:BHF + @@ -78943,8 +115165,18 @@ + Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. mesenchymal cell apoptotic process + + + + Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. + CL:0000134 + GOC:mtg_apoptosis + GOC:yaf + PMID:18231833 + @@ -78969,8 +115201,17 @@ + The chemical reactions and pathways involving the ammonium ion. ammonium ion metabolic process + + + + The chemical reactions and pathways involving the ammonium ion. + GOC:dhl + GOC:tb + PMID:14671018 + @@ -78984,8 +115225,16 @@ + The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. + This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. apoptotic signaling pathway + + + + The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. + GOC:mtg_apoptosis + @@ -79005,8 +115254,16 @@ + A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. execution phase of apoptosis + + + + A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. + GOC:mtg_apoptosis + PMID:21760595 + @@ -79037,8 +115294,149 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. lysosomal membrane organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. + GOC:yaf + PMID:20544854 + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. + cellular response to toxic substance + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. + GOC:pr + + + + + + + + + + The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. + renal tubular secretion + + + + + The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. + GOC:rph + PMID:25287933 + Wikipedia:Renal_secretion#Secretion + + + + + + + + + + + + + + + + + + + + + + + + + + Any biological process involved in the maintenance of an internal steady state of ammonium. + ammonium homeostasis + + + + + Any biological process involved in the maintenance of an internal steady state of ammonium. + GOC:yaf + PMID:12695560 + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell. + intracellular ammonium homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell. + GOC:yaf + PMID:12695560 + + + + + + + + + + + + + + + + + + + + + + + + + + Any apoptotic process in a hepatocyte, the main structural component of the liver. + hepatocyte apoptotic process + + + + + Any apoptotic process in a hepatocyte, the main structural component of the liver. + CL:0000182 + GOC:jc + GOC:mtg_apoptosis + PMID:15856020 + @@ -79063,8 +115461,15 @@ + Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin. protein localization to heterochromatin + + + + Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin. + GOC:mah + @@ -79089,8 +115494,15 @@ + A prolongation or process extending from a glial cell. glial cell projection + + + + A prolongation or process extending from a glial cell. + GOC:mc + @@ -79115,8 +115527,17 @@ + The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron. neuroblast migration + + + + The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron. + CL:0000031 + GOC:jc + PMID:15543145 + @@ -79136,8 +115557,16 @@ + An arrangement of closely apposed microtubules running parallel to each other. + NIF_Subcellular:sao1872343973 microtubule bundle + + + + An arrangement of closely apposed microtubules running parallel to each other. + NIF_Subcellular:sao1872343973 + @@ -79162,8 +115591,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. supramolecular fiber organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. + GOC:pr + @@ -79189,8 +115625,17 @@ + Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina. retinal rod cell apoptotic process + + + + Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina. + CL:0000604 + GOC:jc + PMID:17202487 + @@ -79216,8 +115661,16 @@ + Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina. retinal cone cell apoptotic process + + + + Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina. + CL:0000573 + GOC:jc + @@ -79242,8 +115695,17 @@ + The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. motor neuron migration + + + + The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. + CL:0000100 + GOC:yaf + PMID:20711475 + @@ -79268,8 +115730,17 @@ + The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. spinal cord motor neuron migration + + + + The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. + CL:0011001 + GOC:yaf + PMID:20711475 + @@ -79294,8 +115765,18 @@ + A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. dendritic cell dendrite + + + + A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. + CL:0000451 + GOC:BHF + GOC:cjm + PMID:12200351 + @@ -79320,8 +115801,16 @@ + A cardiac myofibril is a myofibril specific to cardiac muscle cells. cardiac myofibril + + + + A cardiac myofibril is a myofibril specific to cardiac muscle cells. + GOC:cjm + GOC:devbiol + @@ -79346,8 +115835,17 @@ + The movement of a myeloid leukocyte within or between different tissues and organs of the body. myeloid leukocyte migration + + + + The movement of a myeloid leukocyte within or between different tissues and organs of the body. + GOC:cvs + PMID:22342843 + PMID:24157461 + @@ -79372,8 +115870,17 @@ + The movement of a granulocyte within or between different tissues and organs of the body. granulocyte migration + + + + The movement of a granulocyte within or between different tissues and organs of the body. + GOC:cvs + PMID:24163421 + PMID:24193336 + @@ -79398,8 +115905,16 @@ + The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage. lymphoid lineage cell migration + + + + The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage. + GOC:pr + PMID:22342843 + @@ -79425,8 +115940,17 @@ + Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. vacuole fusion + + + + Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. + GOC:pr + GOC:vw + Wikipedia:Vacuole + @@ -79446,8 +115970,15 @@ + Any vesicle that is part of the intracellular region. intracellular vesicle + + + + Any vesicle that is part of the intracellular region. + GOC:vesicles + @@ -79461,8 +115992,21 @@ + The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane. + Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella. ciliary basal body-plasma membrane docking + + + + The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane. + GOC:cilia + PMID:13978319 + PMID:23348840 + PMID:23530209 + PMID:25686250 + PMID:26981235 + @@ -79476,8 +116020,19 @@ + The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. vesicle targeting, trans-Golgi to periciliary membrane compartment + + + + The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. + GOC:cilia + PMID:20106869 + PMID:23351793 + PMID:24814148 + PMID:26485645 + @@ -79485,8 +116040,18 @@ + The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. extracellular exosome biogenesis + + + + The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. + GOC:PARL + GOC:bf + PMID:19442504 + PMID:25392495 + @@ -79515,8 +116080,16 @@ + A neuromuscular junction in which the target muscle cell is a myotube. + In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes. neuromuscular junction of myotube + + + + A neuromuscular junction in which the target muscle cell is a myotube. + GOC:dos + @@ -79542,8 +116115,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract. skeletal muscle fiber differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract. + GOC:dos + @@ -79568,8 +116148,16 @@ + The lipid bilayer that forms the outer-most layer of an organelle. + Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. bounding membrane of organelle + + + + The lipid bilayer that forms the outer-most layer of an organelle. + GOC:dos + @@ -79594,8 +116182,16 @@ + A membrane that is a (regional) part of the plasma membrane. + Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. plasma membrane region + + + + A membrane that is a (regional) part of the plasma membrane. + GOC:dos + @@ -79603,8 +116199,15 @@ + The attachment of one cell to another cell via adhesion molecules. cell-cell adhesion + + + + The attachment of one cell to another cell via adhesion molecules. + GOC:dos + @@ -79629,8 +116232,15 @@ + Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. protein complex involved in cell-cell adhesion + + + + Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. + GOC:dos + @@ -79655,8 +116265,15 @@ + Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell. protein complex involved in cell adhesion + + + + Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell. + GOC:dos + @@ -79681,8 +116298,15 @@ + A collagen trimer that forms networks. network-forming collagen trimer + + + + A collagen trimer that forms networks. + PMID:21421911 + @@ -79691,8 +116315,16 @@ + A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). banded collagen fibril + + + + A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). + GOC:dos + PMID:21421911 + @@ -79712,8 +116344,15 @@ + A complex of collagen trimers such as a fibril or collagen network. complex of collagen trimers + + + + A complex of collagen trimers such as a fibril or collagen network. + GOC:dos + @@ -79722,8 +116361,16 @@ + A supramolecular complex that consists of collagen triple helices associated to form a network. collagen network + + + + A supramolecular complex that consists of collagen triple helices associated to form a network. + GOC:dos + PMID:21421911 + @@ -79748,8 +116395,16 @@ + Any collagen timer that is part of a basement membrane. basement membrane collagen trimer + + + + Any collagen timer that is part of a basement membrane. + GOC:dos + PMID:21421911 + @@ -79794,8 +116449,15 @@ + The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. import into cell + + + + The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. + GOC:dos + @@ -79815,8 +116477,16 @@ + Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity. asymmetric stem cell division + + + + Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity. + GOC:dos + PMID:18513950 + @@ -79841,8 +116511,15 @@ + A myofibril of a skeletal muscle fiber. skeletal muscle myofibril + + + + A myofibril of a skeletal muscle fiber. + GOC:dos + @@ -79862,8 +116539,15 @@ + The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes. germline stem cell asymmetric division + + + + The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes. + GOC:dos + @@ -79894,8 +116578,38 @@ + The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development. bone cell development + + + + The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + GOC:dos + + + + + + + + + + + + + + + Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. + detoxification + + + + + Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. + GOC:dos + @@ -79927,8 +116641,15 @@ + The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. skin epidermis development + + + + The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. + GOC:dos + @@ -79948,8 +116669,15 @@ + The part of a synapse that is part of the presynaptic cell. presynapse + + + + The part of a synapse that is part of the presynaptic cell. + GOC:dos + @@ -79969,8 +116697,15 @@ + The part of a synapse that is part of the post-synaptic cell. postsynapse + + + + The part of a synapse that is part of the post-synaptic cell. + GOC:dos + @@ -79995,8 +116730,15 @@ + Any protein complex that is part of a membrane. membrane protein complex + + + + Any protein complex that is part of a membrane. + GOC:dos + @@ -80021,8 +116763,48 @@ + Any protein complex that is part of the plasma membrane. plasma membrane protein complex + + + + Any protein complex that is part of the plasma membrane. + GOC:dos + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. + regulation of renal system process + + + + + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. + GOC:dos + @@ -80030,8 +116812,15 @@ + The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. nuclear chromosome segregation + + + + The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. + GOC:dos + @@ -80056,8 +116845,15 @@ + The directed movement of a protein along a microtubule, mediated by motor proteins. protein transport along microtubule + + + + The directed movement of a protein along a microtubule, mediated by motor proteins. + PMID:25987607 + @@ -80082,8 +116878,15 @@ + The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. lytic vacuole membrane + + + + The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. + GOC:dos + @@ -80097,8 +116900,15 @@ + A cell projection supported by an assembly of actin filaments, and which lacks microtubules. actin-based cell projection + + + + A cell projection supported by an assembly of actin filaments, and which lacks microtubules. + PMID:15661519 + @@ -80123,8 +116933,15 @@ + The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone. intramembranous bone growth + + + + The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone. + PMID:26399686 + @@ -80155,8 +116972,15 @@ + The increase in size or mass of a bone that contributes to the shaping of that bone. bone growth + + + + The increase in size or mass of a bone that contributes to the shaping of that bone. + GOC:dos + @@ -80176,8 +117000,15 @@ + The actin cytoskeleton that is part of a postsynapse. postsynaptic actin cytoskeleton + + + + The actin cytoskeleton that is part of a postsynapse. + GOC:dos + @@ -80213,8 +117044,15 @@ + The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis. vesicle-mediated transport to the plasma membrane + + + + The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis. + GOC:dos + @@ -80240,8 +117078,19 @@ + A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. synapse pruning + + + + A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. + GOC:dos + PMID:12062020 + PMID:18083105 + PMID:22632716 + PMID:29844190 + @@ -80266,8 +117115,20 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term. regulation of action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:dos + GOC:dph + GOC:go_curators + GOC:tb + ISBN:978-0-07-139011-8 + @@ -80292,8 +117153,16 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. regulation of cardiac muscle cell action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:dos + GOC:mtg_cardiac_conduct_nov11 + @@ -80319,8 +117188,16 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. regulation of AV node cell action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -80346,8 +117223,16 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. regulation of Purkinje myocyte action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -80373,8 +117258,16 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. regulation of SA node cell action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -80400,8 +117293,17 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. regulation of neuronal action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:dph + GOC:isa_complete + GOC:tb + @@ -80436,8 +117338,15 @@ + Cell-cell signaling from pre to post-synapse, across the synaptic cleft. anterograde trans-synaptic signaling + + + + Cell-cell signaling from pre to post-synapse, across the synaptic cleft. + GOC:dos + @@ -80472,8 +117381,15 @@ + Cell-cell signaling from post to pre-synapse, across the synaptic cleft. retrograde trans-synaptic signaling + + + + Cell-cell signaling from post to pre-synapse, across the synaptic cleft. + GOC:dos + @@ -80501,8 +117417,15 @@ + Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. retrograde trans-synaptic signaling by lipid + + + + Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. + GOC:dos + @@ -80533,8 +117456,15 @@ + Signal transduction in which the initial step occurs in a postsynapse. postsynaptic signal transduction + + + + Signal transduction in which the initial step occurs in a postsynapse. + GOC:dos + @@ -80559,8 +117489,15 @@ + Signal transduction in which the initial step occurs in a presynapse. presynaptic signal transduction + + + + Signal transduction in which the initial step occurs in a presynapse. + GOC:dos + @@ -80586,8 +117523,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. postsynaptic actin cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. + GOC:dos + @@ -80622,8 +117566,16 @@ + The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma. postsynapse of neuromuscular junction + + + + The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma. + GOC:dos + Wikipedia:Neuromuscular_junction&oldid=723623502 + @@ -80648,8 +117600,17 @@ + A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. neuronal dense core vesicle + + + + A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. + GOC:dos + ISBN:978-0-07-181001-2 + Wikipedia:Neuropeptide&oldid=713905176 + @@ -80686,8 +117647,15 @@ + Any vesicle-mediated transport that occurs in a synapse. vesicle-mediated transport in synapse + + + + Any vesicle-mediated transport that occurs in a synapse. + GOC:dos + @@ -80718,8 +117686,15 @@ + The lipid bilayer surrounding a neuronal dense core vesicle. neuronal dense core vesicle membrane + + + + The lipid bilayer surrounding a neuronal dense core vesicle. + GOC:dos + @@ -80744,8 +117719,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle. neuronal dense core vesicle organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle. + GOC:dos + @@ -80776,8 +117758,18 @@ + The aggregation, arrangement and bonding together of a set of components to form a presynapse. presynapse assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a presynapse. + GOC:PARL + GOC:bf + GOC:dos + PMID:24449494 + @@ -80808,8 +117800,17 @@ + The aggregation, arrangement and bonding together of a set of components to form a postsynapse. postsynapse assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a postsynapse. + GOC:bf + GOC:dos + GOCL:PARL + @@ -80817,8 +117818,15 @@ + A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. supramolecular complex + + + + A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. + GOC:dos + @@ -80843,8 +117851,15 @@ + A polymeric supramolecular structure. supramolecular polymer + + + + A polymeric supramolecular structure. + GOC:dos + @@ -80872,8 +117887,18 @@ + Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide. retrograde trans-synaptic signaling by neuropeptide + + + + Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide. + GOC:PARL + GOC:bf + GOC:dos + PMID:19448629 + @@ -80905,8 +117930,19 @@ + Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission + + + + Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. + GOC:PARL + GOC:bf + GOC:dos + PMID:19448629 + @@ -80931,8 +117967,16 @@ + The movement of a cellular component as a result of microtubule polymerization. microtubule polymerization based movement + + + + The movement of a cellular component as a result of microtubule polymerization. + GOC:cjm + ISBN:0815316194 + @@ -80957,8 +118001,16 @@ + A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. microtubule-based transport + + + + A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. + GOC:cjm + ISBN:0815316194 + @@ -80992,8 +118044,17 @@ + The transport of a protein driven by polymerization of a microtubule to which it is attached. microtubule polymerization based protein transport + + + + The transport of a protein driven by polymerization of a microtubule to which it is attached. + GOC:dos + GOC:vw + PMID:11018050 + @@ -81018,8 +118079,15 @@ + A microtubule-based process that results in the transport of proteins. microtubule-based protein transport + + + + A microtubule-based process that results in the transport of proteins. + GOC:vw + @@ -81045,8 +118113,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. presynaptic actin cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. + GOC:dos + @@ -81066,8 +118141,15 @@ + The actin cytoskeleton that is part of a presynapse. presynaptic actin cytoskeleton + + + + The actin cytoskeleton that is part of a presynapse. + GOC:dos + @@ -81092,8 +118174,16 @@ + Cell-cell signaling in which the ligand is carried between cells by an exosome. cell-cell signaling via exosome + + + + Cell-cell signaling in which the ligand is carried between cells by an exosome. + GOC:dos + PMID:19837038 + @@ -81113,8 +118203,16 @@ + Transynaptic signaling in which the ligand is carried across the synapse by an exosome. trans-synaptic signaling via exosome + + + + Transynaptic signaling in which the ligand is carried across the synapse by an exosome. + GOC:dos + PMID:19837038 + @@ -81139,8 +118237,15 @@ + Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. postsynaptic modulation of chemical synaptic transmission + + + + Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. + GOC:dos + @@ -81165,8 +118270,15 @@ + Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. presynaptic modulation of chemical synaptic transmission + + + + Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. + GOC:dos + @@ -81197,8 +118309,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. presynapse organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. + GOC:dos + @@ -81229,8 +118348,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. postsynapse organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. + GOC:dos + @@ -81255,8 +118381,17 @@ + Any process that modulates the physical form of a presynapse. regulation of presynapse organization + + + + Any process that modulates the physical form of a presynapse. + GOC:ai + GOC:dph + GOC:tb + @@ -81281,8 +118416,17 @@ + Any process that modulates the physical form of a postsynapse. regulation of postsynapse organization + + + + Any process that modulates the physical form of a postsynapse. + GOC:ai + GOC:dph + GOC:tb + @@ -81308,8 +118452,15 @@ + Any process that modulates the frequency, rate or extent of trans-synaptic signaling. regulation of trans-synaptic signaling + + + + Any process that modulates the frequency, rate or extent of trans-synaptic signaling. + GOC:dos + @@ -81340,8 +118491,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton. presynaptic cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton. + GOC:dos + @@ -81372,8 +118530,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. postsynaptic cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. + GOC:dos + @@ -81407,8 +118572,18 @@ + Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. vesicle fusion to plasma membrane + + + + Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. + GOC:aruk + GOC:bc + ISBN:0071120009 + PMID:18618940 + @@ -81433,8 +118608,15 @@ + The lipid bilayer surrounding an exocytic vesicle. exocytic vesicle membrane + + + + The lipid bilayer surrounding an exocytic vesicle. + GOC:dos + @@ -81459,8 +118641,15 @@ + A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. secretory vesicle + + + + A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. + GOC:dos + @@ -81489,8 +118678,15 @@ + A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. supramolecular fiber + + + + A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. + GOC:dos + @@ -81519,8 +118715,15 @@ + A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. polymeric cytoskeletal fiber + + + + A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. + GOC:dos + @@ -81545,8 +118748,18 @@ + The transport of organelles or other particles from one location in the cell to another along actin filaments. actin filament-based transport + + + + The transport of organelles or other particles from one location in the cell to another along actin filaments. + GOC:dos + GOC:dph + GOC:mah + GOC:tb + @@ -81570,8 +118783,16 @@ + The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. vesicle cytoskeletal trafficking + + + + The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. + GOC:ecd + GOC:rl + @@ -81606,8 +118827,15 @@ + The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. presynaptic process involved in chemical synaptic transmission + + + + The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. + GOC:dos + @@ -81644,8 +118872,15 @@ + Cell-cell signaling to, from or within a synapse. synaptic signaling + + + + Cell-cell signaling to, from or within a synapse. + GOC:dos + @@ -81653,8 +118888,15 @@ + Cell-cell signaling in either direction across the synaptic cleft. trans-synaptic signaling + + + + Cell-cell signaling in either direction across the synaptic cleft. + GOC:dos + @@ -81679,8 +118921,15 @@ + Cell-cell signaling to or from a synapse, mediated by a peptide. synaptic signaling via neuropeptide + + + + Cell-cell signaling to or from a synapse, mediated by a peptide. + GOC:dos + @@ -81700,8 +118949,15 @@ + Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. trans-synaptic signaling by neuropeptide + + + + Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. + GOC:dos + @@ -81726,8 +118982,64 @@ + Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. trans-synaptic signaling by lipid + + + + Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. + GOC:dos + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + protein catabolic process, modulating synaptic transmission + + + + + Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. + GOC:dos + PMID:23083742 + @@ -81761,8 +119073,16 @@ + Any process that modulates synaptic transmission by regulating translation occurring at the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at synapse, modulating synaptic transmission + + + + Any process that modulates synaptic transmission by regulating translation occurring at the synapse. + GOC:dos + @@ -81782,8 +119102,16 @@ + Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling, modulating synaptic transmission + + + + Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. + GOC:dos + @@ -81807,8 +119135,16 @@ + Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by neuropeptide, modulating synaptic transmission + + + + Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. + GOC:dos + @@ -81832,8 +119168,17 @@ + Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by lipid, modulating synaptic transmission + + + + Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. + GOC:dos + PMID:21531987 + @@ -81858,8 +119203,15 @@ + Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. cytoplasmic region + + + + Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. + GOC:dos + @@ -81884,8 +119236,15 @@ + The portion of the cytoskeleton contained within the presynapse. presynaptic cytoskeleton + + + + The portion of the cytoskeleton contained within the presynapse. + GOC:dos + @@ -81910,8 +119269,129 @@ + The portion of the cytoskeleton contained within the postsynapse. postsynaptic cytoskeleton + + + + The portion of the cytoskeleton contained within the postsynapse. + GOC:dos + PMID:19889835 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates synaptic transmission by regulating protein degradation at the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation of protein catabolic process at synapse, modulating synaptic transmission + + + + + Any process that modulates synaptic transmission by regulating protein degradation at the synapse. + GOC:dos + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation of protein catabolic process at presynapse, modulating synaptic transmission + + + + + Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. + GOC:dos + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation of protein catabolic process at postsynapse, modulating synaptic transmission + + + + + Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. + GOC:dos + @@ -81940,8 +119420,16 @@ + Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at presynapse, modulating synaptic transmission + + + + Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. + GOC:dos + @@ -81970,8 +119458,16 @@ + Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at postsynapse, modulating synaptic transmission + + + + Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. + GOC:dos + @@ -82000,8 +119496,15 @@ + A process in which protein is transported from one region of the plasma membrane to another. protein transport within plasma membrane + + + + A process in which protein is transported from one region of the plasma membrane to another. + GOC:dos + @@ -82029,8 +119532,15 @@ + The directed movement of proteins along microtubules in neuron projections. axo-dendritic protein transport + + + + The directed movement of proteins along microtubules in neuron projections. + ISBN:0815316194 + @@ -82073,8 +119583,15 @@ + Any signal release from a synapse. signal release from synapse + + + + Any signal release from a synapse. + GOC:dos + @@ -82100,8 +119617,15 @@ + The complete extent of cell cortex that underlies some some region of the plasma membrane. cell cortex region + + + + The complete extent of cell cortex that underlies some some region of the plasma membrane. + GOC:dos + @@ -82126,8 +119650,16 @@ + Any action potential process that regulates skeletal muscle contraction. regulation of skeletal muscle contraction by action potential + + + + Any action potential process that regulates skeletal muscle contraction. + GOC:cjm + GOC:obol + @@ -82152,8 +119684,18 @@ + The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population. vascular endothelial cell proliferation + + + + The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population. + GOC:BHF + GOC:BHF_telomere + GOC:nc + PMID:23201774 + @@ -82191,8 +119733,17 @@ + A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis. + This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown. mitotic nuclear membrane organization + + + + A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis. + GOC:vw + PMID:15147872 + @@ -82223,8 +119774,15 @@ + The process in which a nuclear membrane is synthesized, aggregates, and bonds together. nuclear membrane biogenesis + + + + The process in which a nuclear membrane is synthesized, aggregates, and bonds together. + GOC:vw + @@ -82249,8 +119807,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. neuron projection organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. + GOC:aruk + GOC:bc + PMID:11585923 + @@ -82276,8 +119843,16 @@ + Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus. regulation of vesicle fusion with Golgi apparatus + + + + Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus. + GOC:se + PMID:26195667 + @@ -82303,8 +119878,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus. negative regulation of vesicle fusion with Golgi apparatus + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus. + GOC:se + PMID:26195667 + @@ -82330,8 +119913,16 @@ + Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus. positive regulation of vesicle fusion with Golgi apparatus + + + + Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus. + GOC:se + PMID:26195667 + @@ -82356,8 +119947,16 @@ + Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. regulation of basement membrane organization + + + + Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. + GOC:ha + PMID:27404358 + @@ -82382,8 +119981,16 @@ + Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. regulation of actomyosin structure organization + + + + Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. + GOC:lf + PMID:22790195 + @@ -82408,8 +120015,18 @@ + The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. cardiac muscle myoblast proliferation + + + + The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:26512644 + @@ -82434,8 +120051,18 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation. regulation of cardiac muscle myoblast proliferation + + + + Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:26512644 + @@ -82461,8 +120088,18 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation. negative regulation of cardiac muscle myoblast proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:26512644 + @@ -82488,8 +120125,18 @@ + Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation. positive regulation of cardiac muscle myoblast proliferation + + + + Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:26512644 + @@ -82515,8 +120162,15 @@ + Any process that modulates the frequency, rate or extent of actin filament organization. regulation of actin filament organization + + + + Any process that modulates the frequency, rate or extent of actin filament organization. + GOC:kmv + @@ -82541,8 +120195,18 @@ + Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation. regulation of blood vessel endothelial cell differentiation + + + + Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:23072816 + @@ -82568,8 +120232,18 @@ + Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation. positive regulation of blood vessel endothelial cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:23072816 + @@ -82595,8 +120269,18 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation. negative regulation of blood vessel endothelial cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:23072816 + @@ -82622,8 +120306,17 @@ + A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane. vesicle-mediated intercellular transport + + + + A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane. + GOC:sp + PMID:29328915 + PMID:29328916 + @@ -82650,8 +120343,15 @@ + Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. positive regulation of animal organ morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. + GOC:kmv + @@ -82678,8 +120378,128 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. negative regulation of animal organ morphogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. + GOC:kmv + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of lipid transporter activity. + regulation of lipid transporter activity + + + + + Any process that modulates the frequency, rate, or extent of lipid transporter activity. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:27365390 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate, or extent of lipid transporter activity. + positive regulation of lipid transporter activity + + + + + Any process that increases the frequency, rate, or extent of lipid transporter activity. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:27365390 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate, or extent of lipid transporter activity. + negative regulation of lipid transporter activity + + + + + Any process that decreases the frequency, rate, or extent of lipid transporter activity. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:27365390 + @@ -82704,8 +120524,16 @@ + Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation. regulation of compound eye photoreceptor cell differentiation + + + + Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation. + GOC:ha + PMID:16377567 + @@ -82731,8 +120559,16 @@ + Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation. positive regulation of compound eye photoreceptor cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation. + GOC:ha + PMID:16377567 + @@ -82758,8 +120594,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation. negative regulation of compound eye photoreceptor cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation. + GOC:ha + PMID:16377567 + @@ -82784,8 +120628,16 @@ + The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse. myotube cell migration + + + + The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse. + GOC:ha + PMID:29122742 + @@ -82810,8 +120662,16 @@ + Any process that modulates the frequency, rate or extent of myotube cell migration. regulation of myotube cell migration + + + + Any process that modulates the frequency, rate or extent of myotube cell migration. + GOC:ha + PMID:29122742 + @@ -82837,8 +120697,16 @@ + Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration. positive regulation of myotube cell migration + + + + Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration. + GOC:ha + PMID:29122742 + @@ -82864,8 +120732,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration. negative regulation of myotube cell migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration. + GOC:ha + PMID:29122742 + @@ -82874,8 +120750,15 @@ + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. cellular anatomical entity + + + + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. + GOC:kmv + @@ -82900,8 +120783,15 @@ + A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. plasma membrane bounded cell projection + + + + A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. + GOC:krc + @@ -82926,8 +120816,15 @@ + Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. plasma membrane bounded cell projection assembly + + + + Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. + GOC:krc + @@ -82952,8 +120849,15 @@ + Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly. regulation of plasma membrane bounded cell projection assembly + + + + Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly. + GOC:krc + @@ -82979,8 +120883,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly. negative regulation of plasma membrane bounded cell projection assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly. + GOC:krc + @@ -83007,8 +120918,15 @@ + Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. positive regulation of plasma membrane bounded cell projection assembly + + + + Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. + GOC:krc + @@ -83033,8 +120951,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections. regulation of plasma membrane bounded cell projection organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections. + GOC:krc + @@ -83059,8 +120984,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon. plasma membrane bounded cell projection organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon. + GOC:krc + @@ -83085,8 +121017,15 @@ + The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized. plasma membrane bounded cell projection morphogenesis + + + + The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized. + GOC:krc + @@ -83111,8 +121050,84 @@ + All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. neuron projection cytoplasm + + + + All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. + GOC:ha + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + positive regulation of collagen catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. + steroid hormone biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. + GOC:krc + GOC:nln + @@ -83138,8 +121153,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin. negative regulation of protein localization to chromatin + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin. + PMID:20889714 + PMID:29899453 + @@ -83165,8 +121188,126 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to chromatin. positive regulation of protein localization to chromatin + + + + Any process that activates or increases the frequency, rate or extent of protein localization to chromatin. + PMID:20889714 + PMID:29899453 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + regulation of bile acid secretion + + + + + Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:22767443 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + positive regulation of bile acid secretion + + + + + Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:22767443 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + negative regulation of bile acid secretion + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:22767443 + @@ -83191,8 +121332,16 @@ + Any process that modulates the frequency, rate or extent of blastocyst development. regulation of blastocyst development + + + + Any process that modulates the frequency, rate or extent of blastocyst development. + GOC:krc + PMID:29593216 + @@ -83217,8 +121366,16 @@ + A process in which a protein is transported to, or maintained in, a location within a motile cilium. protein localization to motile cilium + + + + A process in which a protein is transported to, or maintained in, a location within a motile cilium. + GOC:krc + PMID:27486780 + @@ -83243,8 +121400,15 @@ + Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism. regulation of pigmentation + + + + Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism. + GOC:krc + @@ -83275,8 +121439,16 @@ + The developmental process pertaining to the initial formation of an endothelial tube. endothelial tube formation + + + + The developmental process pertaining to the initial formation of an endothelial tube. + GOC:sl + PMID:23239824 + @@ -83296,8 +121468,15 @@ + One of the two nuclear divisions that occur as part of the meiotic cell cycle. meiotic nuclear division + + + + One of the two nuclear divisions that occur as part of the meiotic cell cycle. + PMID:9334324 + @@ -83317,8 +121496,15 @@ + A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. mitotic nuclear division + + + + A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. + ISBN:0198547684 + @@ -83343,8 +121529,15 @@ + The cellular processes that contribute to exocytosis. exocytic process + + + + The cellular processes that contribute to exocytosis. + Wikipedia:Exocytosis + @@ -83369,8 +121562,15 @@ + The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus. cell-cell adhesion in response to extracellular stimulus + + + + The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus. + PMID:14996911 + @@ -83379,8 +121579,15 @@ + The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other. organelle localization by membrane tethering + + + + The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other. + PMID:27875684 + @@ -83405,8 +121612,18 @@ + Any process that controls lipoprotein transport. regulation of lipoprotein transport + + + + Any process that controls lipoprotein transport. + GOC:BHF + GOC:BHF_miRNA + GOC:RPH + PMID:26501192 + @@ -83432,8 +121649,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport. negative regulation of lipoprotein transport + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport. + GOC:BHF + GOC:BHF_miRNA + GOC:RPH + PMID:26501192 + @@ -83459,8 +121686,154 @@ + Any process that activates or increases the rate or extent of lipoprotein transport. positive regulation of lipoprotein transport + + + + Any process that activates or increases the rate or extent of lipoprotein transport. + GOC:BHF + GOC:BHF_miRNA + GOC:RPH + PMID:26501192 + + + + + + + + + + + + + + + + + + + + + + + + + + Catalytic activity that acts to modify a protein. + catalytic activity, acting on a protein + + + + + Catalytic activity that acts to modify a protein. + GOC:molecular_function_refactoring + GOC:pdt + + + + + + + + + + + + + + + + + + + + + + + + + + Catalytic activity that acts to modify DNA. + catalytic activity, acting on DNA + + + + + Catalytic activity that acts to modify DNA. + GOC:molecular_function_refactoring + GOC:pdt + + + + + + + + + + + + + + + + + + + + + + + + + + Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. + catalytic activity, acting on RNA + + + + + Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. + GOC:molecular_function_refactoring + GOC:pdt + + + + + + + + + + + + + + + + + + + + + + + + + + Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. + catalytic activity, acting on a glycoprotein + + + + + Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. + GOC:molecular_function_refactoring + GOC:pdt + @@ -83468,8 +121841,15 @@ + The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. extracellular vesicle biogenesis + + + + The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. + PMID:28736435 + @@ -83496,8 +121876,15 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis. positive regulation of lymphocyte chemotaxis + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis. + PMID:19255442 + @@ -83522,8 +121909,16 @@ + Translation that occurs at the presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. translation at presynapse + + + + Translation that occurs at the presynapse. + PMID:27321671 + @@ -83552,8 +121947,16 @@ + Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. translation at presynapse, modulating chemical synaptic transmission + + + + Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. + PMID:27321671 + @@ -83580,8 +121983,16 @@ + A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. presynaptic endocytosis + + + + A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. + PMID:24719103 + @@ -83608,8 +122019,16 @@ + A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. postsynaptic endocytosis + + + + A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. + PMID:12839988 + @@ -83646,8 +122065,16 @@ + Translation that occurs at the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. translation at synapse + + + + Translation that occurs at the synapse. + PMID:23083742 + @@ -83672,8 +122099,16 @@ + Translation that occurs at the postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. translation at postsynapse + + + + Translation that occurs at the postsynapse. + PMID:20427644 + @@ -83714,8 +122149,16 @@ + Any process that regulates translation occurring at the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at synapse + + + + Any process that regulates translation occurring at the synapse. + PMID:20427644 + @@ -83744,8 +122187,16 @@ + Any process that regulates translation occurring at the presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at presynapse + + + + Any process that regulates translation occurring at the presynapse. + PMID:20427644 + @@ -83774,8 +122225,292 @@ + Any process that regulates translation occurring at the postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at postsynapse + + + + Any process that regulates translation occurring at the postsynapse. + PMID:20427644 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + protein catabolic process at synapse + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. + PMID:17062563 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + protein catabolic process at presynapse + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse. + PMID:27764673 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + protein catabolic process at postsynapse + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. + PMID:17062563 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation protein catabolic process at synapse + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. + PMID:23083742 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation protein catabolic process at presynapse + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse. + PMID:27764673 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation protein catabolic process at postsynapse + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. + PMID:17062563 + @@ -83789,8 +122524,70 @@ + A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium. cell-cell fusion + + + + A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium. + Wikipedia:Cell_fusion + + + + + + + + + + + + + + + + + + + + + + + + + + Directly binding to a specific protein and delivering it to a specific cellular location. + Reactome:R-HSA-2248891 + Reactome:R-HSA-9662747 + Reactome:R-HSA-9662818 + Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. + protein transporter activity + + + + + Directly binding to a specific protein and delivering it to a specific cellular location. + PMID:18706423 + + + + + Reactome:R-HSA-2248891 + M6PR transports activated ARSA to the lysosome + + + + + Reactome:R-HSA-9662747 + iRHOM2 transports ADAM17 from ER to the Golgi-network + + + + + Reactome:R-HSA-9662818 + iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane + @@ -83826,8 +122623,15 @@ + The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. export from cell + + + + The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. + GOC:pg + @@ -83855,8 +122659,15 @@ + The directed movement of a lipid from a cell, into the extracellular region. lipid export from cell + + + + The directed movement of a lipid from a cell, into the extracellular region. + GOC:pg + @@ -83895,8 +122706,15 @@ + The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. lipid import into cell + + + + The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. + GOC:pg + @@ -83921,8 +122739,15 @@ + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. nuclear protein-containing complex + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. + GOC:pg + @@ -83947,8 +122772,15 @@ + The division of a vacuole within a cell to form two or more separate vacuoles. vacuole fission + + + + The division of a vacuole within a cell to form two or more separate vacuoles. + PMID:19643199 + @@ -83973,8 +122805,76 @@ + The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle. non-membrane-bounded organelle assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle. + PMID:28225081 + + + + + + + + + + + + + + + + + + + + + + + + + + The elimination of ammonium ions from an excretory cell. + ammonium excretion + + + + + The elimination of ammonium ions from an excretory cell. + PMID:25740900 + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. + multicellular organismal-level chemical homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. + GOC:curators + @@ -83999,8 +122899,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to lysosome. regulation of protein localization to lysosome + + + + Any process that modulates the frequency, rate or extent of protein localization to lysosome. + GOC:aruk + GOC:bc + PMID:24305806 + @@ -84026,8 +122935,16 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to lysosome. positive regulation of protein localization to lysosome + + + + Any process that activates or increases the frequency, rate or extent of protein localization to lysosome. + GOC:aruk + GOC:bc + @@ -84053,8 +122970,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome. negative regulation of protein localization to lysosome + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome. + GOC:aruk + GOC:bc + PMID:24305806 + @@ -84079,8 +123005,19 @@ + Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. regulation of postsynapse assembly + + + + Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. + GOC:aruk + GOC:bc + PMID:16394100 + PMID:16672654 + PMID:28185854 + @@ -84088,8 +123025,20 @@ + The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. visual system development + + + + The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. + GOC:aruk + GOC:bc + GOC:krc + PMID:15004427 + PMID:20647017 + PMID:22632727 + @@ -84097,8 +123046,19 @@ + The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents. neuroinflammatory response + + + + The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents. + GOC:aruk + GOC:bc + PMID:10981966 + PMID:11099416 + PMID:18164423 + @@ -84135,8 +123095,19 @@ + Any process that modulates the frequency, rate or extent of neuroinflammatory response. regulation of neuroinflammatory response + + + + Any process that modulates the frequency, rate or extent of neuroinflammatory response. + GOC:aruk + GOC:bc + PMID:10981966 + PMID:11099416 + PMID:18164423 + @@ -84162,8 +123133,16 @@ + Any process that activates or increases the frequency, rate or extent of neuroinflammatory response. positive regulation of neuroinflammatory response + + + + Any process that activates or increases the frequency, rate or extent of neuroinflammatory response. + GOC:aruk + GOC:bc + @@ -84189,8 +123168,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response. negative regulation of neuroinflammatory response + + + + Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response. + GOC:aruk + GOC:bc + PMID:11099416 + PMID:18164423 + @@ -84225,8 +123214,22 @@ + Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum. glial cell-neuron signaling + + + + Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum. + GOC:aruk + GOC:bc + PMID:14980203 + PMID:16144764 + PMID:16547515 + PMID:18685038 + PMID:27788368 + PMID:9459440 + @@ -84261,8 +123264,24 @@ + Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine. neuron-glial cell signaling + + + + Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine. + GOC:aruk + GOC:bc + PMID:10195197 + PMID:10196584 + PMID:10377338 + PMID:10493741 + PMID:11356870 + PMID:11399439 + PMID:15252819 + PMID:27788368 + @@ -84287,8 +123306,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation. negative regulation of monocyte activation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation. + GOC:aruk + PMID:15597323 + @@ -84313,8 +123340,17 @@ + A process in which a protein is transported to, or maintained, in a location within a cell-cell junction. protein localization to cell-cell junction + + + + A process in which a protein is transported to, or maintained, in a location within a cell-cell junction. + GOC:aruk + GOC:bc + PMID:26706435 + @@ -84339,8 +123375,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction. regulation of protein localization to cell-cell junction + + + + Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction. + GOC:aruk + GOC:bc + PMID:26706435 + @@ -84366,8 +123411,17 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction. positive regulation of protein localization to cell-cell junction + + + + Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction. + GOC:aruk + GOC:bc + PMID:26706435 + @@ -84392,8 +123446,16 @@ + Any process that modulates the frequency, rate or extent of transepithelial transport. regulation of transepithelial transport + + + + Any process that modulates the frequency, rate or extent of transepithelial transport. + GOC:aruk + PMID:27593915 + @@ -84419,8 +123481,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction. negative regulation of protein localization to cell-cell junction + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction. + GOC:aruk + GOC:bc + @@ -84445,8 +123515,16 @@ + The disaggregation of a cell junction into its constituent components. cell junction disassembly + + + + The disaggregation of a cell junction into its constituent components. + GOC:aruk + PMID:25490267 + @@ -84471,8 +123549,16 @@ + The disaggregation of a cell-cell junction into its constituent components. cell-cell junction disassembly + + + + The disaggregation of a cell-cell junction into its constituent components. + GOC:aruk + PMID:25490267 + @@ -84497,8 +123583,16 @@ + The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain. somatic sensory system development + + + + The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain. + PMID:25832476 + PMID:31399790 + @@ -84523,8 +123617,43 @@ + The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure. chordate pharynx development + + + + The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure. + PMID:23020903 + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a lipid from one side of a membrane to the other. + lipid transmembrane transporter activity + + + + + Enables the transfer of a lipid from one side of a membrane to the other. + GOC:curators + @@ -84549,8 +123678,15 @@ + Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. regulation of cytokine production involved in inflammatory response + + + + Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. + GOC:TermGenie + @@ -84576,8 +123712,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response. negative regulation of cytokine production involved in inflammatory response + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response. + GOC:TermGenie + @@ -84603,8 +123746,122 @@ + Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response. positive regulation of cytokine production involved in inflammatory response + + + + Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. + regulation of cellular response to insulin stimulus + + + + + Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. + GOC:TermGenie + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. + negative regulation of cellular response to insulin stimulus + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. + GOC:TermGenie + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. + positive regulation of cellular response to insulin stimulus + + + + + Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. + GOC:TermGenie + GOC:yaf + @@ -84629,8 +123886,16 @@ + Any regulation of signal transduction that takes place in the extracellular region. extracellular regulation of signal transduction + + + + Any regulation of signal transduction that takes place in the extracellular region. + GOC:TermGenie + GOC:signaling + @@ -84650,8 +123915,16 @@ + Any negative regulation of signal transduction that takes place in extracellular region. extracellular negative regulation of signal transduction + + + + Any negative regulation of signal transduction that takes place in extracellular region. + GOC:TermGenie + GOC:signaling + @@ -84676,8 +123949,16 @@ + Any process that modulates the frequency, rate or extent of execution phase of apoptosis. regulation of execution phase of apoptosis + + + + Any process that modulates the frequency, rate or extent of execution phase of apoptosis. + GOC:TermGenie + GOC:mtg_apoptosis + @@ -84703,8 +123984,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. negative regulation of execution phase of apoptosis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. + GOC:TermGenie + GOC:mtg_apoptosis + @@ -84730,8 +124019,16 @@ + Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. positive regulation of execution phase of apoptosis + + + + Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. + GOC:TermGenie + GOC:mtg_apoptosis + @@ -84756,8 +124053,16 @@ + Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process. regulation of hyaluronan biosynthetic process + + + + Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process. + GOC:TermGenie + GOC:yaf + @@ -84784,8 +124089,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. negative regulation of hyaluronan biosynthetic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. + GOC:TermGenie + GOC:yaf + @@ -84812,8 +124125,16 @@ + Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process. positive regulation of hyaluronan biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process. + GOC:TermGenie + GOC:yaf + @@ -84840,8 +124161,17 @@ + Any process that modulates the frequency, rate or extent of defense response to fungus. regulation of defense response to fungus + + + + Any process that modulates the frequency, rate or extent of defense response to fungus. + GOC:TermGenie + GOC:dhl + PMID:22242006 + @@ -84866,8 +124196,15 @@ + Any process that modulates the frequency, rate or extent of protein localization to nucleus. regulation of protein localization to nucleus + + + + Any process that modulates the frequency, rate or extent of protein localization to nucleus. + GOC:TermGenie + @@ -84893,8 +124230,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. negative regulation of protein localization to nucleus + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. + GOC:TermGenie + @@ -84920,8 +124264,15 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. positive regulation of protein localization to nucleus + + + + Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. + GOC:TermGenie + @@ -84947,8 +124298,16 @@ + Any process that modulates the frequency, rate or extent of oocyte maturation. regulation of oocyte maturation + + + + Any process that modulates the frequency, rate or extent of oocyte maturation. + GOC:TermGenie + GOC:kmv + @@ -84975,8 +124334,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation. negative regulation of oocyte maturation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation. + GOC:TermGenie + GOC:kmv + @@ -85003,8 +124370,16 @@ + Any process that activates or increases the frequency, rate or extent of oocyte maturation. positive regulation of oocyte maturation + + + + Any process that activates or increases the frequency, rate or extent of oocyte maturation. + GOC:TermGenie + GOC:kmv + @@ -85030,8 +124405,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect. negative regulation of defense response to insect + + + + Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect. + GOC:TermGenie + PMID:22474183 + @@ -85057,8 +124440,16 @@ + Any process that activates or increases the frequency, rate or extent of defense response to insect. positive regulation of defense response to insect + + + + Any process that activates or increases the frequency, rate or extent of defense response to insect. + GOC:TermGenie + PMID:22474183 + @@ -85085,8 +124476,16 @@ + Any process that modulates the frequency, rate or extent of defense response to bacterium. regulation of defense response to bacterium + + + + Any process that modulates the frequency, rate or extent of defense response to bacterium. + GOC:TermGenie + PMID:22346749 + @@ -85114,8 +124513,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. negative regulation of defense response to bacterium + + + + Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. + GOC:TermGenie + PMID:22346749 + @@ -85143,8 +124550,109 @@ + Any process that activates or increases the frequency, rate or extent of defense response to bacterium. positive regulation of defense response to bacterium + + + + Any process that activates or increases the frequency, rate or extent of defense response to bacterium. + GOC:TermGenie + PMID:22346749 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving insulin. + insulin metabolic process + + + + + The chemical reactions and pathways involving insulin. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of insulin. + insulin catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of insulin. + GOC:TermGenie + @@ -85169,8 +124677,17 @@ + Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form. gene expression involved in extracellular matrix organization + + + + Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form. + GOC:TermGenie + GOC:pg + PMID:18668558 + @@ -85195,8 +124712,48 @@ + The chemical reactions and pathways involving primary amino compound. primary amino compound metabolic process + + + + The chemical reactions and pathways involving primary amino compound. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of primary amino compound. + primary amino compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of primary amino compound. + GOC:TermGenie + @@ -85221,8 +124778,15 @@ + The chemical reactions and pathways resulting in the formation of primary amino compound. primary amino compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of primary amino compound. + GOC:TermGenie + @@ -85247,8 +124811,16 @@ + Any process that modulates the frequency, rate or extent of trophoblast cell migration. regulation of trophoblast cell migration + + + + Any process that modulates the frequency, rate or extent of trophoblast cell migration. + GOC:BHF + GOC:TermGenie + @@ -85276,8 +124848,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration. negative regulation of trophoblast cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration. + GOC:BHF + GOC:TermGenie + @@ -85306,8 +124886,16 @@ + Any process that activates or increases the frequency, rate or extent of trophoblast cell migration. positive regulation of trophoblast cell migration + + + + Any process that activates or increases the frequency, rate or extent of trophoblast cell migration. + GOC:BHF + GOC:TermGenie + @@ -85332,8 +124920,16 @@ + Any neural crest cell migration that is involved in autonomic nervous system development. neural crest cell migration involved in autonomic nervous system development + + + + Any neural crest cell migration that is involved in autonomic nervous system development. + GOC:BHF + GOC:TermGenie + @@ -85358,8 +124954,15 @@ + Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex. regulation of formation of translation initiation ternary complex + + + + Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex. + GOC:TermGenie + @@ -85386,8 +124989,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex. negative regulation of formation of translation initiation ternary complex + + + + Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex. + GOC:TermGenie + @@ -85413,8 +125023,15 @@ + Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex. positive regulation of formation of translation initiation ternary complex + + + + Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex. + GOC:TermGenie + @@ -85440,8 +125057,16 @@ + Any process that modulates the frequency, rate or extent of extracellular matrix assembly. regulation of extracellular matrix assembly + + + + Any process that modulates the frequency, rate or extent of extracellular matrix assembly. + GOC:BHF + GOC:TermGenie + @@ -85467,8 +125092,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. negative regulation of extracellular matrix assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. + GOC:BHF + GOC:TermGenie + @@ -85495,8 +125128,16 @@ + Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. positive regulation of extracellular matrix assembly + + + + Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. + GOC:BHF + GOC:TermGenie + @@ -85521,8 +125162,16 @@ + Any process that modulates the frequency, rate or extent of cardiac chamber formation. regulation of cardiac chamber formation + + + + Any process that modulates the frequency, rate or extent of cardiac chamber formation. + GOC:BHF + GOC:TermGenie + @@ -85548,8 +125197,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation. negative regulation of cardiac chamber formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation. + GOC:BHF + GOC:TermGenie + @@ -85575,8 +125232,16 @@ + Any process that activates or increases the frequency, rate or extent of cardiac chamber formation. positive regulation of cardiac chamber formation + + + + Any process that activates or increases the frequency, rate or extent of cardiac chamber formation. + GOC:BHF + GOC:TermGenie + @@ -85601,8 +125266,16 @@ + Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis. regulation of cardiac chamber morphogenesis + + + + Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis. + GOC:BHF + GOC:TermGenie + @@ -85628,8 +125301,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis. negative regulation of cardiac chamber morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis. + GOC:BHF + GOC:TermGenie + @@ -85655,8 +125336,16 @@ + Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis. positive regulation of cardiac chamber morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis. + GOC:BHF + GOC:TermGenie + @@ -85681,8 +125370,16 @@ + Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation. regulation of lung ciliated cell differentiation + + + + Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation. + GOC:BHF + GOC:TermGenie + @@ -85709,8 +125406,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation. negative regulation of lung ciliated cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation. + GOC:BHF + GOC:TermGenie + @@ -85737,8 +125442,16 @@ + Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation. positive regulation of lung ciliated cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation. + GOC:BHF + GOC:TermGenie + @@ -85763,8 +125476,15 @@ + Any process that modulates the frequency, rate or extent of vasculature development. regulation of vasculature development + + + + Any process that modulates the frequency, rate or extent of vasculature development. + GOC:TermGenie + @@ -85791,8 +125511,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. negative regulation of vasculature development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. + GOC:TermGenie + @@ -85817,8 +125544,16 @@ + Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis. regulation of endothelial tube morphogenesis + + + + Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis. + GOC:TermGenie + GOC:dph + @@ -85843,8 +125578,17 @@ + Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. regulation of hematopoietic progenitor cell differentiation + + + + Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + @@ -85870,8 +125614,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. negative regulation of hematopoietic progenitor cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + @@ -85897,8 +125650,17 @@ + Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. positive regulation of hematopoietic progenitor cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + @@ -85924,8 +125686,17 @@ + Any process that modulates the frequency, rate or extent of endothelial cell development. regulation of endothelial cell development + + + + Any process that modulates the frequency, rate or extent of endothelial cell development. + GOC:TermGenie + GOC:pr + PMID:19470579 + @@ -85952,8 +125723,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development. negative regulation of endothelial cell development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development. + GOC:TermGenie + GOC:pr + PMID:19470579 + @@ -85979,8 +125759,17 @@ + Any process that activates or increases the frequency, rate or extent of endothelial cell development. positive regulation of endothelial cell development + + + + Any process that activates or increases the frequency, rate or extent of endothelial cell development. + GOC:TermGenie + GOC:pr + PMID:19470579 + @@ -86005,8 +125794,50 @@ + The chemical reactions and pathways involving organonitrogen compound. organonitrogen compound metabolic process + + + + The chemical reactions and pathways involving organonitrogen compound. + GOC:TermGenie + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. + organonitrogen compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. + GOC:TermGenie + GOC:pr + @@ -86032,8 +125863,16 @@ + The chemical reactions and pathways resulting in the formation of organonitrogen compound. organonitrogen compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of organonitrogen compound. + GOC:TermGenie + GOC:pr + @@ -86058,8 +125897,15 @@ + Any process that modulates the frequency, rate or extent of vesicle transport along microtubule. regulation of vesicle transport along microtubule + + + + Any process that modulates the frequency, rate or extent of vesicle transport along microtubule. + GOC:TermGenie + @@ -86085,8 +125931,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule. negative regulation of vesicle transport along microtubule + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule. + GOC:TermGenie + @@ -86112,8 +125965,15 @@ + Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule. positive regulation of vesicle transport along microtubule + + + + Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule. + GOC:TermGenie + @@ -86138,8 +125998,50 @@ + The chemical reactions and pathways involving organic hydroxy compound. organic hydroxy compound metabolic process + + + + The chemical reactions and pathways involving organic hydroxy compound. + GOC:TermGenie + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. + organic hydroxy compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. + GOC:TermGenie + GOC:pr + @@ -86165,8 +126067,50 @@ + The chemical reactions and pathways resulting in the formation of organic hydroxy compound. organic hydroxy compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of organic hydroxy compound. + GOC:TermGenie + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of organic hydroxy compound from one side of a membrane to the other. + organic hydroxy compound transmembrane transporter activity + + + + + Enables the transfer of organic hydroxy compound from one side of a membrane to the other. + GOC:TermGenie + GOC:pr + @@ -86192,8 +126136,15 @@ + Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. regulation of lymphocyte chemotaxis + + + + Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. + GOC:TermGenie + @@ -86220,8 +126171,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis. negative regulation of lymphocyte chemotaxis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis. + GOC:TermGenie + @@ -86246,8 +126204,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. response to peptide + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. + GOC:TermGenie + GOC:pr + @@ -86267,8 +126233,79 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. cellular response to peptide + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. + GOC:TermGenie + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + A response that results in a state of tolerance to ketone. + response to ketone + + + + + A response that results in a state of tolerance to ketone. + GOC:mengo_curators + PMID:23356676 + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. + cellular response to ketone + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. + GOC:TermGenie + GOC:pr + @@ -86293,8 +126330,17 @@ + Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process. regulation of compound eye retinal cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process. + GOC:TermGenie + GOC:mtg_apoptosis + PMID:12021768 + @@ -86320,8 +126366,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process. negative regulation of compound eye retinal cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process. + GOC:TermGenie + GOC:mtg_apoptosis + PMID:12021768 + @@ -86348,8 +126403,17 @@ + Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process. positive regulation of compound eye retinal cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process. + GOC:TermGenie + GOC:mtg_apoptosis + PMID:12021768 + @@ -86374,8 +126438,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to nitrogen compound + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. + GOC:TermGenie + GOC:pr + @@ -86395,8 +126468,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular response to nitrogen compound + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. + GOC:TermGenie + GOC:pr + @@ -86421,8 +126503,17 @@ + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state. mesenchymal cell differentiation involved in bone development + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state. + GOC:TermGenie + GOC:hjd + PMID:21571217 + @@ -86447,8 +126538,17 @@ + Any process that modulates the frequency, rate or extent of muscle tissue development. regulation of muscle tissue development + + + + Any process that modulates the frequency, rate or extent of muscle tissue development. + GOC:TermGenie + GOC:yaf + PMID:23150719 + @@ -86474,8 +126574,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. negative regulation of muscle tissue development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. + GOC:TermGenie + GOC:yaf + PMID:23150719 + @@ -86501,8 +126610,17 @@ + Any process that activates or increases the frequency, rate or extent of muscle tissue development. positive regulation of muscle tissue development + + + + Any process that activates or increases the frequency, rate or extent of muscle tissue development. + GOC:TermGenie + GOC:yaf + PMID:23150719 + @@ -86527,8 +126645,18 @@ + Any process that modulates the frequency, rate or extent of protein depolymerization. regulation of protein depolymerization + + + + Any process that modulates the frequency, rate or extent of protein depolymerization. + GOC:BHF + GOC:TermGenie + GOC:rl + PMID:12032137 + @@ -86554,8 +126682,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization. negative regulation of protein depolymerization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization. + GOC:BHF + GOC:TermGenie + GOC:rl + PMID:12032137 + @@ -86581,8 +126719,18 @@ + Any process that activates or increases the frequency, rate or extent of protein depolymerization. positive regulation of protein depolymerization + + + + Any process that activates or increases the frequency, rate or extent of protein depolymerization. + GOC:BHF + GOC:TermGenie + GOC:rl + PMID:12032137 + @@ -86608,8 +126756,15 @@ + Any process that modulates the frequency, rate or extent of cell junction assembly. regulation of cell junction assembly + + + + Any process that modulates the frequency, rate or extent of cell junction assembly. + GOC:TermGenie + @@ -86635,8 +126790,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. negative regulation of cell junction assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. + GOC:TermGenie + @@ -86663,8 +126825,15 @@ + Any process that activates or increases the frequency, rate or extent of cell junction assembly. positive regulation of cell junction assembly + + + + Any process that activates or increases the frequency, rate or extent of cell junction assembly. + GOC:TermGenie + @@ -86689,8 +126858,18 @@ + Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. regulation of cell proliferation involved in outflow tract morphogenesis + + + + Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_heart + PMID:21419760 + @@ -86716,8 +126895,18 @@ + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. positive regulation of cell proliferation involved in outflow tract morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_heart + PMID:21419760 + @@ -86769,8 +126958,18 @@ + Any process that modulates the frequency, rate or extent of cilium assembly. regulation of cilium assembly + + + + Any process that modulates the frequency, rate or extent of cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:dph + PMID:17719545 + @@ -86797,8 +126996,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. negative regulation of cilium assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:dph + PMID:17719545 + @@ -86823,8 +127032,17 @@ + Any process that modulates the frequency, rate or extent of cilium-dependent cell motility. regulation of cilium-dependent cell motility + + + + Any process that modulates the frequency, rate or extent of cilium-dependent cell motility. + GOC:TermGenie + GOC:cilia + GOC:jl + @@ -86850,8 +127068,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility. negative regulation of cilium-dependent cell motility + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility. + GOC:TermGenie + GOC:cilia + GOC:jl + @@ -86876,8 +127103,16 @@ + Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation. regulation of hematopoietic stem cell proliferation + + + + Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation. + GOC:TermGenie + PMID:23403623 + @@ -86904,8 +127139,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation. negative regulation of hematopoietic stem cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation. + GOC:TermGenie + PMID:23403623 + @@ -86931,8 +127174,16 @@ + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation. positive regulation of hematopoietic stem cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation. + GOC:TermGenie + PMID:23403623 + @@ -86958,8 +127209,16 @@ + Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. regulation of hematopoietic stem cell differentiation + + + + Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. + GOC:TermGenie + PMID:23403623 + @@ -86986,8 +127245,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation. negative regulation of hematopoietic stem cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation. + GOC:TermGenie + PMID:23403623 + @@ -87014,8 +127281,16 @@ + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation. positive regulation of hematopoietic stem cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation. + GOC:TermGenie + PMID:23403623 + @@ -87040,8 +127315,16 @@ + Any process that modulates the frequency, rate or extent of leukocyte differentiation. regulation of leukocyte differentiation + + + + Any process that modulates the frequency, rate or extent of leukocyte differentiation. + GOC:TermGenie + GOC:add + @@ -87067,8 +127350,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. negative regulation of leukocyte differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. + GOC:TermGenie + GOC:add + @@ -87094,8 +127385,16 @@ + Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. positive regulation of leukocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. + GOC:TermGenie + GOC:add + @@ -87121,8 +127420,16 @@ + Any process that modulates the frequency, rate or extent of organelle assembly. regulation of organelle assembly + + + + Any process that modulates the frequency, rate or extent of organelle assembly. + GOC:TermGenie + GOC:pr + @@ -87148,8 +127455,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. negative regulation of organelle assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. + GOC:TermGenie + GOC:pr + @@ -87176,8 +127491,16 @@ + Any process that activates or increases the frequency, rate or extent of organelle assembly. positive regulation of organelle assembly + + + + Any process that activates or increases the frequency, rate or extent of organelle assembly. + GOC:TermGenie + GOC:pr + @@ -87228,8 +127551,19 @@ + Any apoptotic process in an erythrocyte. erythrocyte apoptotic process + + + + Any apoptotic process in an erythrocyte. + GOC:BHF + GOC:TermGenie + GOC:mtg_apoptosis + GOC:rl + PMID:14569084 + @@ -87254,8 +127588,19 @@ + Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process. regulation of erythrocyte apoptotic process + + + + Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process. + GOC:BHF + GOC:TermGenie + GOC:mtg_apoptosis + GOC:rl + PMID:14569084 + @@ -87307,8 +127652,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process. negative regulation of erythrocyte apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process. + GOC:BHF + GOC:TermGenie + GOC:mtg_apoptosis + GOC:rl + PMID:14569084 + @@ -87360,8 +127716,19 @@ + Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process. positive regulation of erythrocyte apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process. + GOC:BHF + GOC:TermGenie + GOC:mtg_apoptosis + GOC:rl + PMID:14569084 + @@ -87386,8 +127753,18 @@ + Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. regulation of apoptotic process involved in outflow tract morphogenesis + + + + Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_apoptosis + PMID:16839542 + @@ -87413,8 +127790,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. negative regulation of apoptotic process involved in outflow tract morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_apoptosis + PMID:16839542 + @@ -87440,8 +127827,18 @@ + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. positive regulation of apoptotic process involved in outflow tract morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_apoptosis + PMID:16839542 + @@ -87466,8 +127863,18 @@ + Any apoptotic process that is involved in blood vessel morphogenesis. apoptotic process involved in blood vessel morphogenesis + + + + Any apoptotic process that is involved in blood vessel morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_apoptosis + PMID:16163358 + @@ -87492,8 +127899,19 @@ + Any process that modulates the frequency, rate or extent of chromatin organization. regulation of chromatin organization + + + + Any process that modulates the frequency, rate or extent of chromatin organization. + GOC:TermGenie + GOC:bf + GOC:vw + GO_REF:0000058 + PMID:18314879 + @@ -87518,8 +127936,17 @@ + Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis. regulation of apoptotic process involved in morphogenesis + + + + Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis. + GOC:TermGenie + GOC:sart + PMID:12202035 + @@ -87545,8 +127972,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis. negative regulation of apoptotic process involved in morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis. + GOC:TermGenie + GOC:sart + PMID:12202035 + @@ -87572,8 +128008,17 @@ + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis. positive regulation of apoptotic process involved in morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis. + GOC:TermGenie + GOC:sart + PMID:12202035 + @@ -87599,8 +128044,51 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation. negative regulation of chromosome condensation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation. + GOC:TermGenie + PMID:23219725 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. + negative regulation of RNA catabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. + GOC:TermGenie + GOC:bf + PMID:16640457 + @@ -87625,8 +128113,16 @@ + A process in which a protein is transported to, or maintained in, a location within a cell junction. protein localization to cell junction + + + + A process in which a protein is transported to, or maintained in, a location within a cell junction. + GOC:TermGenie + PMID:18332111 + @@ -87651,8 +128147,17 @@ + A process in which a protein is transported to, or maintained in, a location within a cell leading edge. protein localization to cell leading edge + + + + A process in which a protein is transported to, or maintained in, a location within a cell leading edge. + GOC:TermGenie + GOC:lb + PMID:21543326 + @@ -87677,8 +128182,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to synapse. regulation of protein localization to synapse + + + + Any process that modulates the frequency, rate or extent of protein localization to synapse. + GOC:TermGenie + GOC:kmv + PMID:22588719 + @@ -87704,8 +128218,265 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to synapse. positive regulation of protein localization to synapse + + + + Any process that activates or increases the frequency, rate or extent of protein localization to synapse. + GOC:TermGenie + GOC:kmv + PMID:22588719 + + + + + + + + + + + + + + + + + + + + + + + + + + Any apoptotic process in a cholangiocyte. + cholangiocyte apoptotic process + + + + + Any apoptotic process in a cholangiocyte. + GOC:TermGenie + PMID:22961800 + + + + + + + + + + + + + + + + + + + + + + + + + + Any apoptotic process in a hepatoblast. + hepatoblast apoptotic process + + + + + Any apoptotic process in a hepatoblast. + GOC:TermGenie + PMID:22412967 + + + + + + + + + + + + + + + + + + + + + + + + + + A protein complex which is capable of catalytic activity. + catalytic complex + + + + + A protein complex which is capable of catalytic activity. + GOC:TermGenie + GOC:bhm + PMID:8077207 + + + + + + + + + + + + + + + + + + + + + + + + + + + A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. + transmembrane transporter complex + + + + + A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. + GOC:TermGenie + GOC:bhm + PMID:18024586 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation. + DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). + regulation of apoptotic DNA fragmentation + + + + + Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation. + GOC:TermGenie + GOC:hjd + PMID:15572351 + PMID:15723341 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation. + negative regulation of apoptotic DNA fragmentation + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation. + GOC:TermGenie + GOC:hjd + PMID:15572351 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation. + positive regulation of apoptotic DNA fragmentation + + + + + Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation. + GOC:TermGenie + GOC:hjd + PMID:15572351 + @@ -87731,8 +128502,17 @@ + Any process that modulates the frequency, rate or extent of organelle transport along microtubule. regulation of organelle transport along microtubule + + + + Any process that modulates the frequency, rate or extent of organelle transport along microtubule. + GOC:TermGenie + GOC:dph + PMID:21147087 + @@ -87757,8 +128537,18 @@ + Any process that modulates the frequency, rate or extent of intracellular signal transduction. regulation of intracellular signal transduction + + + + Any process that modulates the frequency, rate or extent of intracellular signal transduction. + GOC:TermGenie + GOC:dph + GOC:signaling + GOC:tb + @@ -87784,8 +128574,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. negative regulation of intracellular signal transduction + + + + Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. + GOC:TermGenie + GOC:dph + GOC:signaling + GOC:tb + @@ -87811,8 +128611,19 @@ + Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. positive regulation of intracellular signal transduction + + + + Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. + GOC:BHF + GOC:TermGenie + GOC:dph + GOC:signaling + GOC:tb + @@ -87837,8 +128648,16 @@ + A process in which a protein is transported to, or maintained in, a location within a nucleolus. protein localization to nucleolus + + + + A process in which a protein is transported to, or maintained in, a location within a nucleolus. + GOC:TermGenie + PMID:22809626 + @@ -87864,8 +128683,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. negative regulation of RNA biosynthetic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. + GO:jl + GOC:TermGenie + GO_REF:0000058 + @@ -87891,8 +128719,17 @@ + Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process. positive regulation of RNA biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process. + GO:jl + GOC:TermGenie + GO_REF:0000058 + @@ -87917,8 +128754,19 @@ + Any process that modulates the frequency, rate or extent of neuroblast proliferation. regulation of neuroblast proliferation + + + + Any process that modulates the frequency, rate or extent of neuroblast proliferation. + GOC:PARL + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:21168496 + @@ -87945,8 +128793,17 @@ + Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. regulation of chondrocyte differentiation involved in endochondral bone morphogenesis + + + + Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. + GOC:TermGenie + GO_REF:0000058 + PMID:8662546 + @@ -87971,8 +128828,18 @@ + Any apoptotic process that is involved in anatomical structure development. apoptotic process involved in development + + + + Any apoptotic process that is involved in anatomical structure development. + GOC:TermGenie + GOC:mtg_apoptosis + GOC:pg + GO_REF:0000060 + @@ -87999,8 +128866,18 @@ + Any process that activates or increases the frequency, rate or extent of chondrocyte development. positive regulation of chondrocyte development + + + + Any process that activates or increases the frequency, rate or extent of chondrocyte development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16575901 + @@ -88026,8 +128903,18 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation. regulation of skeletal muscle fiber differentiation + + + + Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:17879321 + @@ -88054,8 +128941,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation. negative regulation of skeletal muscle fiber differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:17879321 + @@ -88082,8 +128979,18 @@ + Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation. positive regulation of skeletal muscle fiber differentiation + + + + Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:17879321 + @@ -88108,8 +129015,18 @@ + Any process that modulates the frequency, rate or extent of protein localization to microtubule. regulation of protein localization to microtubule + + + + Any process that modulates the frequency, rate or extent of protein localization to microtubule. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + PMID:23087209 + @@ -88135,8 +129052,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule. negative regulation of protein localization to microtubule + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + PMID:23087209 + @@ -88161,8 +129088,17 @@ + Any process that modulates the frequency, rate or extent of nuclear migration along microtubule. regulation of nuclear migration along microtubule + + + + Any process that modulates the frequency, rate or extent of nuclear migration along microtubule. + GOC:TermGenie + GO_REF:0000058 + PMID:23087209 + @@ -88188,8 +129124,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule. negative regulation of nuclear migration along microtubule + + + + Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule. + GOC:TermGenie + GO_REF:0000058 + PMID:23087209 + @@ -88215,8 +129160,17 @@ + Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule. positive regulation of nuclear migration along microtubule + + + + Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule. + GOC:TermGenie + GO_REF:0000058 + PMID:23087209 + @@ -88236,8 +129190,17 @@ + Any microtubule cytoskeleton organization that is involved in mitosis. microtubule cytoskeleton organization involved in mitosis + + + + Any microtubule cytoskeleton organization that is involved in mitosis. + GOC:TermGenie + GO_REF:0000060 + PMID:18799626 + @@ -88262,8 +129225,18 @@ + Any process that modulates the frequency, rate or extent of embryonic camera-type eye development. regulation of embryonic camera-type eye development + + + + Any process that modulates the frequency, rate or extent of embryonic camera-type eye development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88289,8 +129262,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development. negative regulation of embryonic camera-type eye development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88316,8 +129299,18 @@ + Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development. positive regulation of embryonic camera-type eye development + + + + Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88342,8 +129335,18 @@ + Any process that modulates the frequency, rate or extent of retina development in camera-type eye. regulation of retina development in camera-type eye + + + + Any process that modulates the frequency, rate or extent of retina development in camera-type eye. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88370,8 +129373,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye. negative regulation of retina development in camera-type eye + + + + Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88398,8 +129411,18 @@ + Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye. positive regulation of retina development in camera-type eye + + + + Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88424,8 +129447,18 @@ + Any process that modulates the frequency, rate or extent of embryonic pattern specification. regulation of embryonic pattern specification + + + + Any process that modulates the frequency, rate or extent of embryonic pattern specification. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88451,8 +129484,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification. negative regulation of embryonic pattern specification + + + + Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88478,8 +129521,18 @@ + Any process that activates or increases the frequency, rate or extent of embryonic pattern specification. positive regulation of embryonic pattern specification + + + + Any process that activates or increases the frequency, rate or extent of embryonic pattern specification. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88504,8 +129557,20 @@ + Any process that modulates the frequency, rate or extent of supramolecular fiber organization. + HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro regulation of supramolecular fiber organization + + + + Any process that modulates the frequency, rate or extent of supramolecular fiber organization. + GOC:PARL + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23921388 + @@ -88531,8 +129596,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization. + HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro negative regulation of supramolecular fiber organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization. + GOC:PARL + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23921388 + @@ -88558,8 +129635,20 @@ + Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization. + HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro positive regulation of supramolecular fiber organization + + + + Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization. + GOC:PARL + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23921388 + @@ -88584,8 +129673,18 @@ + Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation. positive regulation of neuroepithelial cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16916506 + @@ -88610,8 +129709,16 @@ + The disaggregation of an organelle into its constituent components. organelle disassembly + + + + The disaggregation of an organelle into its constituent components. + GOC:TermGenie + GO_REF:0000079 + @@ -88636,8 +129743,18 @@ + Any process that modulates the frequency, rate or extent of bone development. regulation of bone development + + + + Any process that modulates the frequency, rate or extent of bone development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:22510437 + @@ -88664,8 +129781,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of bone development. negative regulation of bone development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of bone development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:22510437 + @@ -88692,8 +129819,18 @@ + Any process that activates or increases the frequency, rate or extent of bone development. positive regulation of bone development + + + + Any process that activates or increases the frequency, rate or extent of bone development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:22510437 + @@ -88718,8 +129855,20 @@ + Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. + human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein regulation of glycoprotein metabolic process + + + + Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23544079 + @@ -88745,8 +129894,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. + human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein negative regulation of glycoprotein metabolic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23544079 + @@ -88772,8 +129933,20 @@ + Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. + human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein positive regulation of glycoprotein metabolic process + + + + Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23544079 + @@ -88798,8 +129971,20 @@ + Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion. + Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion regulation of leukocyte cell-cell adhesion + + + + Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:21106532 + @@ -88825,8 +130010,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion. + Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion negative regulation of leukocyte cell-cell adhesion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:21106532 + @@ -88852,8 +130049,20 @@ + Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion. + Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion positive regulation of leukocyte cell-cell adhesion + + + + Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:21106532 + @@ -88878,8 +130087,20 @@ + Any neural crest cell migration that is involved in sympathetic nervous system development. + Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development neural crest cell migration involved in sympathetic nervous system development + + + + Any neural crest cell migration that is involved in sympathetic nervous system development. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000060 + PMID:19325129 + @@ -88906,8 +130127,17 @@ + A process that is part of the meiotic cell cycle. meiotic cell cycle process + + + + A process that is part of the meiotic cell cycle. + GOC:TermGenie + GOC:mtg_cell_cycle + GO_REF:0000060 + @@ -88932,8 +130162,17 @@ + A process that is part of the mitotic cell cycle. mitotic cell cycle process + + + + A process that is part of the mitotic cell cycle. + GOC:TermGenie + GOC:mtg_cell_cycle + GO_REF:0000060 + @@ -88958,8 +130197,19 @@ + Any process that modulates the frequency, rate or extent of extracellular matrix organization. regulation of extracellular matrix organization + + + + Any process that modulates the frequency, rate or extent of extracellular matrix organization. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:22357537 + @@ -88985,8 +130235,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. negative regulation of extracellular matrix organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:22357537 + @@ -89012,8 +130273,19 @@ + Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. positive regulation of extracellular matrix organization + + + + Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:22357537 + @@ -89038,8 +130310,19 @@ + Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. regulation of protein localization to plasma membrane + + + + Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:11602640 + @@ -89065,8 +130348,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. negative regulation of protein localization to plasma membrane + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:11602640 + @@ -89092,8 +130386,19 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. positive regulation of protein localization to plasma membrane + + + + Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:11602640 + @@ -89118,8 +130423,17 @@ + Any process that modulates the frequency, rate or extent of actin filament-based movement. regulation of actin filament-based movement + + + + Any process that modulates the frequency, rate or extent of actin filament-based movement. + GOC:TermGenie + GO_REF:0000058 + PMID:24798735 + @@ -89145,8 +130459,17 @@ + Any process that activates or increases the frequency, rate or extent of actin filament-based movement. positive regulation of actin filament-based movement + + + + Any process that activates or increases the frequency, rate or extent of actin filament-based movement. + GOC:TermGenie + GO_REF:0000058 + PMID:24798735 + @@ -89171,8 +130494,17 @@ + A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton. protein localization to actin cytoskeleton + + + + A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton. + GOC:TermGenie + GO_REF:0000087 + PMID:24798735 + @@ -89197,8 +130529,17 @@ + A process in which a protein is transported to, or maintained in, the location of an actin filament bundle. protein localization to actin filament bundle + + + + A process in which a protein is transported to, or maintained in, the location of an actin filament bundle. + GOC:TermGenie + GO_REF:0000087 + PMID:24798735 + @@ -89223,8 +130564,18 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. mononuclear cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. + CL:0000842 + GOC:TermGenie + GO_REF:0000086 + PMID:24759906 + @@ -89249,8 +130600,18 @@ + Any process that modulates the frequency, rate or extent of endodermal cell differentiation. regulation of endodermal cell differentiation + + + + Any process that modulates the frequency, rate or extent of endodermal cell differentiation. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23154389 + @@ -89276,8 +130637,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation. negative regulation of endodermal cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23154389 + @@ -89303,8 +130674,18 @@ + Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation. positive regulation of endodermal cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23154389 + @@ -89329,8 +130710,19 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell. multi-ciliated epithelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell. + GOC:TermGenie + GOC:sp + GO_REF:0000086 + PMID:22231168 + PMID:24934224 + @@ -89355,8 +130747,17 @@ + A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. protein localization to Golgi membrane + + + + A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. + GOC:TermGenie + GO_REF:0000087 + PMID:11378902 + @@ -89381,8 +130782,17 @@ + Any process that modulates the frequency, rate or extent of vacuolar transport. regulation of vacuolar transport + + + + Any process that modulates the frequency, rate or extent of vacuolar transport. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + @@ -89408,8 +130818,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport. negative regulation of vacuolar transport + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + @@ -89435,8 +130854,17 @@ + Any process that activates or increases the frequency, rate or extent of vacuolar transport. positive regulation of vacuolar transport + + + + Any process that activates or increases the frequency, rate or extent of vacuolar transport. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + @@ -89461,8 +130889,17 @@ + Any process that modulates the frequency, rate or extent of nucleus organization. regulation of nucleus organization + + + + Any process that modulates the frequency, rate or extent of nucleus organization. + GOC:TermGenie + GO_REF:0000058 + PMID:16943282 + @@ -89487,8 +130924,18 @@ + Any process that modulates the frequency, rate or extent of Golgi organization. regulation of Golgi organization + + + + Any process that modulates the frequency, rate or extent of Golgi organization. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:17562788 + @@ -89514,8 +130961,17 @@ + Any process that modulates the frequency, rate or extent of mitotic chromosome condensation. regulation of mitotic chromosome condensation + + + + Any process that modulates the frequency, rate or extent of mitotic chromosome condensation. + GOC:TermGenie + GO_REF:0000058 + PMID:9490640 + @@ -89542,8 +130998,86 @@ + Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation. positive regulation of mitotic chromosome condensation + + + + Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation. + GOC:TermGenie + GO_REF:0000058 + PMID:9490640 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. + response to bile acid + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000071 + PMID:21757002 + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. + cellular response to bile acid + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000071 + PMID:21757002 + @@ -89568,8 +131102,17 @@ + Any process that modulates the frequency, rate or extent of cell maturation. regulation of cell maturation + + + + Any process that modulates the frequency, rate or extent of cell maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:17459944 + @@ -89595,8 +131138,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. negative regulation of cell maturation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:17459944 + @@ -89622,8 +131174,17 @@ + Any process that activates or increases the frequency, rate or extent of cell maturation. positive regulation of cell maturation + + + + Any process that activates or increases the frequency, rate or extent of cell maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:17459944 + @@ -89648,8 +131209,55 @@ + A process in which a protein is transported to, or maintained in, a location within a ciliary membrane. protein localization to ciliary membrane + + + + A process in which a protein is transported to, or maintained in, a location within a ciliary membrane. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000087 + PMID:22139371 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving mucopolysaccharide. + mucopolysaccharide metabolic process + + + + + The chemical reactions and pathways involving mucopolysaccharide. + GOC:TermGenie + GOC:dph + GO_REF:0000068 + PMID:4236091 + @@ -89674,8 +131282,18 @@ + Any process that modulates the frequency, rate or extent of blood circulation. regulation of blood circulation + + + + Any process that modulates the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + @@ -89701,8 +131319,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. negative regulation of blood circulation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + @@ -89728,8 +131356,18 @@ + Any process that activates or increases the frequency, rate or extent of blood circulation. positive regulation of blood circulation + + + + Any process that activates or increases the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + @@ -89755,8 +131393,18 @@ + Any process that modulates the frequency, rate or extent of secretion by cell. regulation of secretion by cell + + + + Any process that modulates the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + @@ -89783,8 +131431,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. negative regulation of secretion by cell + + + + Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + @@ -89811,8 +131469,18 @@ + Any process that activates or increases the frequency, rate or extent of secretion by cell. positive regulation of secretion by cell + + + + Any process that activates or increases the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + @@ -89837,8 +131505,18 @@ + Any meiotic cell cycle process that is involved in oocyte maturation. meiotic cell cycle process involved in oocyte maturation + + + + Any meiotic cell cycle process that is involved in oocyte maturation. + GOC:TermGenie + GOC:jz + GO_REF:0000060 + PMID:25212395 + @@ -89864,8 +131542,18 @@ + Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. regulation of meiotic cell cycle process involved in oocyte maturation + + + + Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. + GOC:TermGenie + GOC:jz + GO_REF:0000058 + PMID:25212395 + @@ -89890,8 +131578,17 @@ + Any process that modulates the frequency, rate or extent of exosomal secretion. regulation of exosomal secretion + + + + Any process that modulates the frequency, rate or extent of exosomal secretion. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -89917,8 +131614,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion. negative regulation of exosomal secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -89945,8 +131651,17 @@ + Any process that activates or increases the frequency, rate or extent of exosomal secretion. positive regulation of exosomal secretion + + + + Any process that activates or increases the frequency, rate or extent of exosomal secretion. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -89971,8 +131686,17 @@ + Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly. regulation of extracellular exosome assembly + + + + Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -89998,8 +131722,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly. negative regulation of extracellular exosome assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -90025,8 +131758,17 @@ + Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly. positive regulation of extracellular exosome assembly + + + + Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -90046,8 +131788,18 @@ + Any vesicle that is part of the extracellular region. extracellular vesicle + + + + Any vesicle that is part of the extracellular region. + GOC:TermGenie + GOC:pm + GO_REF:0000064 + PMID:24769233 + @@ -90072,8 +131824,19 @@ + Any process that modulates the frequency, rate or extent of protein localization to cilium. regulation of protein localization to cilium + + + + Any process that modulates the frequency, rate or extent of protein localization to cilium. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + @@ -90099,8 +131862,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium. negative regulation of protein localization to cilium + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + @@ -90126,8 +131900,19 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to cilium. positive regulation of protein localization to cilium + + + + Any process that activates or increases the frequency, rate or extent of protein localization to cilium. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + @@ -90152,8 +131937,19 @@ + Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane. regulation of protein localization to ciliary membrane + + + + Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + @@ -90179,8 +131975,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane. negative regulation of protein localization to ciliary membrane + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + @@ -90206,8 +132013,126 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane. positive regulation of protein localization to ciliary membrane + + + + Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of DNA catabolic process. + regulation of DNA catabolic process + + + + + Any process that modulates the frequency, rate or extent of DNA catabolic process. + GOC:TermGenie + GO_REF:0000058 + PMID:2001740 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process. + negative regulation of DNA catabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process. + GOC:TermGenie + GO_REF:0000058 + PMID:2001740 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of DNA catabolic process. + positive regulation of DNA catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of DNA catabolic process. + GOC:TermGenie + GO_REF:0000058 + PMID:2001740 + @@ -90233,8 +132158,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly. negative regulation of microvillus assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:22797597 + @@ -90260,8 +132195,18 @@ + Any process that activates or increases the frequency, rate or extent of microvillus assembly. positive regulation of microvillus assembly + + + + Any process that activates or increases the frequency, rate or extent of microvillus assembly. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:22797597 + @@ -90286,8 +132231,17 @@ + The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure. substantia propria of cornea development + + + + The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure. + GOC:TermGenie + GO_REF:0000094 + PMID:12556382 + @@ -90312,8 +132266,17 @@ + The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure. esophagus development + + + + The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure. + GOC:TermGenie + GO_REF:0000094 + ISBN:0-683-40008-8 + @@ -90340,8 +132303,20 @@ + Any process that modulates the frequency, rate or extent of hemopoiesis. + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. regulation of hemopoiesis + + + + Any process that modulates the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 + @@ -90369,8 +132344,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. negative regulation of hemopoiesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 + @@ -90398,8 +132385,20 @@ + Any process that activates or increases the frequency, rate or extent of hemopoiesis. + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. positive regulation of hemopoiesis + + + + Any process that activates or increases the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 + @@ -90424,8 +132423,17 @@ + Any process that modulates the frequency, rate or extent of plasma membrane organization. regulation of plasma membrane organization + + + + Any process that modulates the frequency, rate or extent of plasma membrane organization. + GOC:TermGenie + GO_REF:0000058 + PMID:24514900 + @@ -90450,8 +132458,17 @@ + A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane. protein localization to vacuolar membrane + + + + A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane. + GOC:TermGenie + GO_REF:0000087 + PMID:25378562 + @@ -90476,8 +132493,20 @@ + Any process that modulates the frequency, rate or extent of cardiac conduction. regulation of cardiac conduction + + + + Any process that modulates the frequency, rate or extent of cardiac conduction. + GOC:BHF + GOC:TermGenie + GOC:mtg_cardiac_conduct_nov11 + GOC:rph + GO_REF:0000058 + PMID:12967627 + @@ -90503,8 +132532,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction. negative regulation of cardiac conduction + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction. + GOC:BHF + GOC:TermGenie + GOC:mtg_cardiac_conduct_nov11 + GOC:rph + GO_REF:0000058 + PMID:12967627 + @@ -90530,8 +132571,53 @@ + Any process that activates or increases the frequency, rate or extent of cardiac conduction. positive regulation of cardiac conduction + + + + Any process that activates or increases the frequency, rate or extent of cardiac conduction. + GOC:BHF + GOC:TermGenie + GOC:mtg_cardiac_conduct_nov11 + GOC:rph + GO_REF:0000058 + PMID:12967627 + + + + + + + + + + + + + + + + + + + + + + + + + The process in which an organic acid is transported across a membrane. + organic acid transmembrane transport + + + + + The process in which an organic acid is transported across a membrane. + GOC:TermGenie + GO_REF:0000069 + @@ -90557,8 +132643,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. negative regulation of protein localization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + @@ -90584,8 +132679,17 @@ + Any process that activates or increases the frequency, rate or extent of a protein localization. positive regulation of protein localization + + + + Any process that activates or increases the frequency, rate or extent of a protein localization. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + @@ -90610,8 +132714,17 @@ + Any signal transduction that is involved in cellular response to ammonium ion. signal transduction involved in cellular response to ammonium ion + + + + Any signal transduction that is involved in cellular response to ammonium ion. + GOC:TermGenie + GO_REF:0000060 + PMID:16297994 + @@ -90636,8 +132749,20 @@ + Any process that modulates the frequency, rate or extent of aorta morphogenesis. regulation of aorta morphogenesis + + + + Any process that modulates the frequency, rate or extent of aorta morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22269326 + @@ -90663,8 +132788,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis. negative regulation of aorta morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22269326 + @@ -90690,8 +132827,20 @@ + Any process that activates or increases the frequency, rate or extent of aorta morphogenesis. positive regulation of aorta morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of aorta morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22269326 + @@ -90716,8 +132865,17 @@ + The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure. extraembryonic membrane development + + + + The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure. + GOC:TermGenie + GO_REF:0000094 + ISBN:0073040584 + @@ -90742,8 +132900,18 @@ + Any process that modulates the frequency, rate or extent of establishment of T cell polarity. regulation of establishment of T cell polarity + + + + Any process that modulates the frequency, rate or extent of establishment of T cell polarity. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23575248 + @@ -90769,8 +132937,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity. negative regulation of establishment of T cell polarity + + + + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23575248 + @@ -90796,8 +132974,18 @@ + Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity. positive regulation of establishment of T cell polarity + + + + Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23575248 + @@ -90823,8 +133011,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. negative regulation of respiratory gaseous exchange + + + + Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. + GOC:TermGenie + GO_REF:0000058 + PMID:22819705 + @@ -90850,8 +133047,124 @@ + Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. positive regulation of respiratory gaseous exchange + + + + Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. + GOC:TermGenie + GO_REF:0000058 + PMID:22819705 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process. + regulation of hepatocyte apoptotic process + + + + + Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:8649852 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process. + negative regulation of hepatocyte apoptotic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:8649852 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process. + positive regulation of hepatocyte apoptotic process + + + + + Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:8649852 + @@ -90877,8 +133190,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential. negative regulation of AV node cell action potential + + + + Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential. + GOC:BHF + GOC:TermGenie + GOC:mtg_cardiac_conduct_nov11 + GOC:nc + GO_REF:0000058 + PMID:25281747 + @@ -90904,8 +133229,20 @@ + Any process that activates or increases the frequency, rate or extent of AV node cell action potential. positive regulation of AV node cell action potential + + + + Any process that activates or increases the frequency, rate or extent of AV node cell action potential. + GOC:BHF + GOC:TermGenie + GOC:mtg_cardiac_conduct_nov11 + GOC:nc + GO_REF:0000058 + PMID:25281747 + @@ -90930,8 +133267,19 @@ + Any process that modulates the frequency, rate or extent of glial cell migration. regulation of glial cell migration + + + + Any process that modulates the frequency, rate or extent of glial cell migration. + GOC:BHF + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:19100238 + @@ -90957,8 +133305,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration. negative regulation of glial cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration. + GOC:BHF + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:19100238 + @@ -90984,8 +133343,19 @@ + Any process that activates or increases the frequency, rate or extent of glial cell migration. positive regulation of glial cell migration + + + + Any process that activates or increases the frequency, rate or extent of glial cell migration. + GOC:BHF + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:19100238 + @@ -91010,8 +133380,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. response to serotonin + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:1505525 + @@ -91031,8 +133410,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. cellular response to serotonin + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:1505525 + @@ -91059,8 +133447,17 @@ + Any process that activates or increases the frequency, rate or extent of vasculature development. positive regulation of vasculature development + + + + Any process that activates or increases the frequency, rate or extent of vasculature development. + GOC:TermGenie + GO_REF:0000058 + PMID:21472453 + @@ -91111,8 +133508,17 @@ + Any apoptotic process in an epithelial cell. epithelial cell apoptotic process + + + + Any apoptotic process in an epithelial cell. + GOC:TermGenie + GO_REF:0000085 + PMID:19137015 + @@ -91138,8 +133544,17 @@ + Any process that modulates the frequency, rate or extent of collagen fibril organization. regulation of collagen fibril organization + + + + Any process that modulates the frequency, rate or extent of collagen fibril organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25451920 + @@ -91166,8 +133581,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization. negative regulation of collagen fibril organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25451920 + @@ -91194,8 +133618,17 @@ + Any process that activates or increases the frequency, rate or extent of collagen fibril organization. positive regulation of collagen fibril organization + + + + Any process that activates or increases the frequency, rate or extent of collagen fibril organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25451920 + @@ -91220,8 +133653,17 @@ + Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. regulation of epithelial cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:19137015 + @@ -91247,8 +133689,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. negative regulation of epithelial cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:19137015 + @@ -91274,8 +133725,124 @@ + Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. positive regulation of epithelial cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:19137015 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of cholangiocyte proliferation. + regulation of cholangiocyte proliferation + + + + + Any process that modulates the frequency, rate or extent of cholangiocyte proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24434010 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation. + negative regulation of cholangiocyte proliferation + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24434010 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation. + positive regulation of cholangiocyte proliferation + + + + + Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24434010 + @@ -91301,8 +133868,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. negative regulation of sensory perception of pain + + + + Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. + GOC:TermGenie + GO_REF:0000058 + PMID:17167094 + @@ -91328,8 +133904,17 @@ + Any process that activates or increases the frequency, rate or extent of sensory perception of pain. positive regulation of sensory perception of pain + + + + Any process that activates or increases the frequency, rate or extent of sensory perception of pain. + GOC:TermGenie + GO_REF:0000058 + PMID:17167094 + @@ -91355,8 +133940,17 @@ + Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation. regulation of trophectodermal cell proliferation + + + + Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24508636 + @@ -91382,8 +133976,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation. negative regulation of trophectodermal cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24508636 + @@ -91409,8 +134012,17 @@ + Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation. positive regulation of trophectodermal cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24508636 + @@ -91435,8 +134047,18 @@ + A process in which a protein is transported to, or maintained in, a location within a microvillus. protein localization to microvillus + + + + A process in which a protein is transported to, or maintained in, a location within a microvillus. + GOC:TermGenie + GOC:kmv + GO_REF:0000087 + PMID:25335890 + @@ -91464,8 +134086,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. negative regulation of meiotic cell cycle process involved in oocyte maturation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:22674394 + @@ -91492,8 +134123,17 @@ + Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. positive regulation of meiotic cell cycle process involved in oocyte maturation + + + + Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:22674394 + @@ -91518,8 +134158,18 @@ + Any process that modulates the frequency, rate or extent of bleb assembly. regulation of bleb assembly + + + + Any process that modulates the frequency, rate or extent of bleb assembly. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:25651887 + @@ -91545,8 +134195,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly. negative regulation of bleb assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:25651887 + @@ -91572,8 +134232,18 @@ + Any process that activates or increases the frequency, rate or extent of bleb assembly. positive regulation of bleb assembly + + + + Any process that activates or increases the frequency, rate or extent of bleb assembly. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:25651887 + @@ -91598,8 +134268,17 @@ + Any process that modulates the frequency, rate or extent of adipose tissue development. regulation of adipose tissue development + + + + Any process that modulates the frequency, rate or extent of adipose tissue development. + GOC:TermGenie + GO_REF:0000058 + PMID:23081848 + @@ -91626,8 +134305,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. negative regulation of adipose tissue development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. + GOC:TermGenie + GO_REF:0000058 + PMID:23081848 + @@ -91654,8 +134342,124 @@ + Any process that activates or increases the frequency, rate or extent of adipose tissue development. positive regulation of adipose tissue development + + + + Any process that activates or increases the frequency, rate or extent of adipose tissue development. + GOC:TermGenie + GO_REF:0000058 + PMID:23081848 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process. + regulation of cholangiocyte apoptotic process + + + + + Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:24498161 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process. + negative regulation of cholangiocyte apoptotic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:24498161 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process. + positive regulation of cholangiocyte apoptotic process + + + + + Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:24498161 + @@ -91681,8 +134485,17 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy. regulation of skeletal muscle hypertrophy + + + + Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy. + GOC:TermGenie + GO_REF:0000058 + PMID:23470307 + @@ -91709,8 +134522,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy. negative regulation of skeletal muscle hypertrophy + + + + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy. + GOC:TermGenie + GO_REF:0000058 + PMID:23470307 + @@ -91737,8 +134559,17 @@ + Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy. positive regulation of skeletal muscle hypertrophy + + + + Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy. + GOC:TermGenie + GO_REF:0000058 + PMID:23470307 + @@ -91763,8 +134594,131 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell. pericyte cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell. + GOC:TermGenie + GOC:dph + GO_REF:0000086 + PMID:23868830 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of bile acid metabolic process. + regulation of bile acid metabolic process + + + + + Any process that modulates the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. + negative regulation of bile acid metabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. + positive regulation of bile acid metabolic process + + + + + Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 + @@ -91789,8 +134743,232 @@ + The cell cortex of the leading edge of a cell. cell leading edge cell cortex + + + + The cell cortex of the leading edge of a cell. + GOC:TermGenie + GOC:kmv + GO_REF:0000064 + PMID:25843030 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + regulation of gastro-intestinal system smooth muscle contraction + + + + + Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:10821044 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + negative regulation of gastro-intestinal system smooth muscle contraction + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:10821044 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + positive regulation of gastro-intestinal system smooth muscle contraction + + + + + Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:10821044 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of colon smooth muscle contraction. + regulation of colon smooth muscle contraction + + + + + Any process that modulates the frequency, rate or extent of colon smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:24170253 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction. + negative regulation of colon smooth muscle contraction + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:24170253 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction. + positive regulation of colon smooth muscle contraction + + + + + Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:24170253 + @@ -91815,8 +134993,17 @@ + Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation. regulation of gastric mucosal blood circulation + + + + Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation. + GOC:TermGenie + GO_REF:0000058 + PMID:10807413 + @@ -91842,8 +135029,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation. negative regulation of gastric mucosal blood circulation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation. + GOC:TermGenie + GO_REF:0000058 + PMID:10807413 + @@ -91869,8 +135065,237 @@ + Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation. positive regulation of gastric mucosal blood circulation + + + + Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation. + GOC:TermGenie + GO_REF:0000058 + PMID:10807413 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction. + regulation of small intestine smooth muscle contraction + + + + + Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:11991626 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction. + negative regulation of small intestine smooth muscle contraction + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:11991626 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction. + positive regulation of small intestine smooth muscle contraction + + + + + Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:11991626 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole. + regulation of protein catabolic process in the vacuole + + + + + Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:25635054 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole. + negative regulation of protein catabolic process in the vacuole + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:25635054 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole. + positive regulation of protein catabolic process in the vacuole + + + + + Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:25635054 + @@ -91895,8 +135320,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to cell periphery. regulation of protein localization to cell periphery + + + + Any process that modulates the frequency, rate or extent of protein localization to cell periphery. + GOC:TermGenie + GO_REF:0000058 + PMID:18216290 + @@ -91922,8 +135356,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. negative regulation of protein localization to cell periphery + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. + GOC:TermGenie + GO_REF:0000058 + PMID:18216290 + @@ -91949,8 +135392,17 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. positive regulation of protein localization to cell periphery + + + + Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. + GOC:TermGenie + GO_REF:0000058 + PMID:18216290 + @@ -91975,8 +135427,17 @@ + Any process that modulates the frequency, rate or extent of neuromuscular junction development. regulation of neuromuscular junction development + + + + Any process that modulates the frequency, rate or extent of neuromuscular junction development. + GOC:TermGenie + GO_REF:0000058 + PMID:7722643 + @@ -92002,8 +135463,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development. negative regulation of neuromuscular junction development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development. + GOC:TermGenie + GO_REF:0000058 + PMID:7722643 + @@ -92029,8 +135499,17 @@ + Any process that activates or increases the frequency, rate or extent of neuromuscular junction development. positive regulation of neuromuscular junction development + + + + Any process that activates or increases the frequency, rate or extent of neuromuscular junction development. + GOC:TermGenie + GO_REF:0000058 + PMID:7722643 + @@ -92055,8 +135534,17 @@ + Any process that modulates the frequency, rate or extent of secretory granule organization. regulation of secretory granule organization + + + + Any process that modulates the frequency, rate or extent of secretory granule organization. + GOC:TermGenie + GO_REF:0000058 + PMID:15039777 + @@ -92082,8 +135570,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization. negative regulation of secretory granule organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization. + GOC:TermGenie + GO_REF:0000058 + PMID:15039777 + @@ -92109,8 +135606,17 @@ + Any process that activates or increases the frequency, rate or extent of secretory granule organization. positive regulation of secretory granule organization + + + + Any process that activates or increases the frequency, rate or extent of secretory granule organization. + GOC:TermGenie + GO_REF:0000058 + PMID:15039777 + @@ -92135,8 +135641,17 @@ + Any process that modulates the frequency, rate or extent of cardiac ventricle development. regulation of cardiac ventricle development + + + + Any process that modulates the frequency, rate or extent of cardiac ventricle development. + GOC:TermGenie + GO_REF:0000058 + PMID:19590510 + @@ -92163,8 +135678,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development. negative regulation of cardiac ventricle development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development. + GOC:TermGenie + GO_REF:0000058 + PMID:19590510 + @@ -92191,8 +135715,17 @@ + Any process that activates or increases the frequency, rate or extent of cardiac ventricle development. positive regulation of cardiac ventricle development + + + + Any process that activates or increases the frequency, rate or extent of cardiac ventricle development. + GOC:TermGenie + GO_REF:0000058 + PMID:19590510 + @@ -92219,8 +135752,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. negative regulation of neuronal action potential + + + + Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. + GOC:TermGenie + GO_REF:0000058 + PMID:25126967 + @@ -92247,8 +135789,53 @@ + Any process that activates or increases the frequency, rate or extent of neuronal action potential. positive regulation of neuronal action potential + + + + Any process that activates or increases the frequency, rate or extent of neuronal action potential. + GOC:TermGenie + GO_REF:0000058 + PMID:25126967 + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure. + cloacal gland development + + + + + The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure. + GOC:TermGenie + GOC:mr + GO_REF:0000094 + PMID:18805421 + @@ -92273,8 +135860,18 @@ + A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone. protein localization to ciliary transition zone + + + + A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone. + GOC:TermGenie + GOC:kmv + GO_REF:0000087 + PMID:21422230 + @@ -92299,8 +135896,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. response to glycoprotein + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:14597422 + @@ -92320,8 +135926,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. cellular response to glycoprotein + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:14597422 + @@ -92346,8 +135961,17 @@ + Any apoptotic process in a fat cell. fat cell apoptotic process + + + + Any apoptotic process in a fat cell. + GOC:TermGenie + GO_REF:0000085 + PMID:17024416 + @@ -92372,8 +135996,17 @@ + Any process that modulates the frequency, rate or extent of fat cell apoptotic process. regulation of fat cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of fat cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:17024416 + @@ -92399,8 +136032,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process. negative regulation of fat cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:17024416 + @@ -92426,8 +136068,17 @@ + Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process. positive regulation of fat cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:17024416 + @@ -92452,8 +136103,17 @@ + Any process that modulates the frequency, rate or extent of lung alveolus development. regulation of lung alveolus development + + + + Any process that modulates the frequency, rate or extent of lung alveolus development. + GOC:TermGenie + GO_REF:0000058 + PMID:23962064 + @@ -92480,8 +136140,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development. negative regulation of lung alveolus development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development. + GOC:TermGenie + GO_REF:0000058 + PMID:23962064 + @@ -92508,8 +136177,56 @@ + Any process that activates or increases the frequency, rate or extent of lung alveolus development. positive regulation of lung alveolus development + + + + Any process that activates or increases the frequency, rate or extent of lung alveolus development. + GOC:TermGenie + GO_REF:0000058 + PMID:23962064 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which glucose is transported across a membrane. + glucose transmembrane transport + + + + + The process in which glucose is transported across a membrane. + GOC:TermGenie + GO_REF:0000069 + PMID:9090050 + @@ -92534,8 +136251,20 @@ + Any process that modulates the frequency, rate or extent of somatic stem cell division. regulation of somatic stem cell division + + + + Any process that modulates the frequency, rate or extent of somatic stem cell division. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19409607 + @@ -92561,8 +136290,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division. negative regulation of somatic stem cell division + + + + Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19409607 + @@ -92588,8 +136329,138 @@ + Any process that activates or increases the frequency, rate or extent of somatic stem cell division. positive regulation of somatic stem cell division + + + + Any process that activates or increases the frequency, rate or extent of somatic stem cell division. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19409607 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a peptide from one side of a membrane to the other. + Reactome:R-HSA-1500817 + peptide transmembrane transporter activity + + + + + Enables the transfer of a peptide from one side of a membrane to the other. + GOC:TermGenie + GOC:vw + GO_REF:0000070 + + + + + Reactome:R-HSA-1500817 + Glutathione is taken up by the bacterium + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation. + negative regulation of type B pancreatic cell proliferation + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24055447 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation. + positive regulation of type B pancreatic cell proliferation + + + + + Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24055447 + @@ -92626,8 +136497,126 @@ + The developmental process by which a midbrain is generated and organized. midbrain morphogenesis + + + + The developmental process by which a midbrain is generated and organized. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000083 + PMID:21347250 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of acinar cell proliferation. + regulation of acinar cell proliferation + + + + + Any process that modulates the frequency, rate or extent of acinar cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:9788538 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation. + negative regulation of acinar cell proliferation + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:9788538 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of acinar cell proliferation. + positive regulation of acinar cell proliferation + + + + + Any process that activates or increases the frequency, rate or extent of acinar cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:9788538 + @@ -92652,8 +136641,17 @@ + Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation. regulation of vascular associated smooth muscle cell proliferation + + + + Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:23246467 + @@ -92679,8 +136677,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. negative regulation of vascular associated smooth muscle cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:23246467 + @@ -92706,8 +136713,17 @@ + Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. positive regulation of vascular associated smooth muscle cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:23246467 + @@ -92732,8 +136748,20 @@ + The orderly movement of a vascular associated smooth muscle cell from one site to another. vascular associated smooth muscle cell migration + + + + The orderly movement of a vascular associated smooth muscle cell from one site to another. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000091 + PMID:20693317 + @@ -92760,8 +136788,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development. + U4PR86 in PMID:22801495 inferred from mutant phenotype negative regulation of apoptotic process involved in development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development. + GOC:TermGenie + GO_REF:0000058 + PMID:22801495 + @@ -92788,8 +136826,18 @@ + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. + U4PR86 in PMID:22801495 inferred from mutant phenotype positive regulation of apoptotic process involved in development + + + + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. + GOC:TermGenie + GO_REF:0000058 + PMID:22801495 + @@ -92815,8 +136863,18 @@ + Any process that modulates the frequency, rate or extent of apoptotic process involved in development. + Q10943 in PMID:22801495, inferred from mutant phenotype regulation of apoptotic process involved in development + + + + Any process that modulates the frequency, rate or extent of apoptotic process involved in development. + GOC:TermGenie + GO_REF:0000058 + PMID:22801495 + @@ -92841,8 +136899,20 @@ + Any process that modulates the frequency, rate or extent of protein localization to nucleolus. regulation of protein localization to nucleolus + + + + Any process that modulates the frequency, rate or extent of protein localization to nucleolus. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:24415760 + @@ -92868,8 +136938,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus. negative regulation of protein localization to nucleolus + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:24415760 + @@ -92895,8 +136977,20 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus. positive regulation of protein localization to nucleolus + + + + Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:24415760 + @@ -92921,8 +137015,20 @@ + Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration. regulation of vascular associated smooth muscle cell migration + + + + Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:20693317 + @@ -92948,8 +137054,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration. negative regulation of vascular associated smooth muscle cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:20693317 + @@ -92975,8 +137093,20 @@ + Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration. positive regulation of vascular associated smooth muscle cell migration + + + + Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:20693317 + @@ -93001,8 +137131,17 @@ + The developmental process by which an intramembranous bone is generated and organized. intramembranous bone morphogenesis + + + + The developmental process by which an intramembranous bone is generated and organized. + GOC:TermGenie + GO_REF:0000083 + PMID:26399686 + @@ -93027,8 +137166,18 @@ + Any process that modulates the frequency, rate or extent of protein localization to cell cortex. + An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. regulation of protein localization to cell cortex + + + + Any process that modulates the frequency, rate or extent of protein localization to cell cortex. + GOC:TermGenie + GO_REF:0000058 + PMID:17115027 + @@ -93054,8 +137203,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex. + An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. negative regulation of protein localization to cell cortex + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex. + GOC:TermGenie + GO_REF:0000058 + PMID:17115027 + @@ -93081,8 +137240,18 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex. + An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. positive regulation of protein localization to cell cortex + + + + Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex. + GOC:TermGenie + GO_REF:0000058 + PMID:17115027 + @@ -93107,8 +137276,18 @@ + The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure. serous membrane development + + + + The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure. + GOC:TermGenie + GOC:dph + GO_REF:0000094 + PMID:15840053 + @@ -93139,8 +137318,18 @@ + The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure. visceral peritoneum development + + + + The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure. + GOC:TermGenie + GOC:dph + GO_REF:0000094 + PMID:15840053 + @@ -93171,8 +137360,18 @@ + The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure. parietal peritoneum development + + + + The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure. + GOC:TermGenie + GOC:dph + GO_REF:0000094 + PMID:15840053 + @@ -93197,8 +137396,18 @@ + The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure. peritoneum development + + + + The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure. + GOC:TermGenie + GOC:dph + GO_REF:0000094 + PMID:15840053 + @@ -93223,8 +137432,20 @@ + Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation. regulation of aortic smooth muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22034194 + @@ -93250,8 +137471,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation. negative regulation of aortic smooth muscle cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22034194 + @@ -93277,8 +137510,20 @@ + Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation. positive regulation of aortic smooth muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22034194 + @@ -93303,8 +137548,19 @@ + The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. cranial skeletal system development + + + + The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000094 + PMID:11262227 + @@ -93329,8 +137585,20 @@ + Any process that modulates the frequency, rate or extent of cell proliferation in midbrain. regulation of cell proliferation in midbrain + + + + Any process that modulates the frequency, rate or extent of cell proliferation in midbrain. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:18953410 + PMID:24431302 + @@ -93356,8 +137624,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain. negative regulation of cell proliferation in midbrain + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:18953410 + PMID:24431302 + @@ -93383,8 +137663,19 @@ + Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain. positive regulation of cell proliferation in midbrain + + + + Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:24431302 + @@ -93409,8 +137700,18 @@ + The orderly movement of an interneuron from one site to another. interneuron migration + + + + The orderly movement of an interneuron from one site to another. + GOC:TermGenie + GOC:ah + GO_REF:0000091 + PMID:18622031 + @@ -93435,8 +137736,18 @@ + The orderly movement of a sensory neuron from one site to another. sensory neuron migration + + + + The orderly movement of a sensory neuron from one site to another. + GOC:TermGenie + GOC:ah + GO_REF:0000091 + PMID:18622031 + @@ -93461,8 +137772,20 @@ + Any process that modulates the frequency, rate or extent of cardiac ventricle formation. regulation of cardiac ventricle formation + + + + Any process that modulates the frequency, rate or extent of cardiac ventricle formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23575307 + @@ -93489,8 +137812,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation. negative regulation of cardiac ventricle formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23575307 + @@ -93516,8 +137851,20 @@ + Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation. positive regulation of cardiac ventricle formation + + + + Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23575307 + @@ -93543,8 +137890,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. negative regulation of establishment of protein localization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. + GOC:TermGenie + GO_REF:0000058 + PMID:22761445 + @@ -93570,8 +137926,17 @@ + Any process that activates or increases the frequency, rate or extent of establishment of protein localization. positive regulation of establishment of protein localization + + + + Any process that activates or increases the frequency, rate or extent of establishment of protein localization. + GOC:TermGenie + GO_REF:0000058 + PMID:22761445 + @@ -93596,8 +137961,20 @@ + Any process that modulates the frequency, rate or extent of endothelial cell activation. regulation of endothelial cell activation + + + + Any process that modulates the frequency, rate or extent of endothelial cell activation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:24255059 + @@ -93623,8 +138000,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation. negative regulation of endothelial cell activation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:24255059 + @@ -93650,8 +138039,54 @@ + Any process that activates or increases the frequency, rate or extent of endothelial cell activation. positive regulation of endothelial cell activation + + + + Any process that activates or increases the frequency, rate or extent of endothelial cell activation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:24255059 + + + + + + + + + + + + + + + + + + + + + + + + + The process in which carboxylic acid is transported across a membrane. + carboxylic acid transmembrane transport + + + + + The process in which carboxylic acid is transported across a membrane. + GOC:TermGenie + GO_REF:0000069 + PMID:10869563 + @@ -93676,8 +138111,20 @@ + Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation. regulation of vascular associated smooth muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19088079 + @@ -93703,8 +138150,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation. negative regulation of vascular associated smooth muscle cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19088079 + @@ -93730,8 +138189,20 @@ + Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation. positive regulation of vascular associated smooth muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19088079 + @@ -93757,8 +138228,17 @@ + Any process that modulates the frequency, rate or extent of axo-dendritic protein transport. regulation of axo-dendritic protein transport + + + + Any process that modulates the frequency, rate or extent of axo-dendritic protein transport. + GOC:TermGenie + GO_REF:0000058 + PMID:20694152 + @@ -93784,8 +138264,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport. negative regulation of axo-dendritic protein transport + + + + Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport. + GOC:TermGenie + GO_REF:0000058 + PMID:20694152 + @@ -93811,8 +138300,17 @@ + Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport. positive regulation of axo-dendritic protein transport + + + + Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport. + GOC:TermGenie + GO_REF:0000058 + PMID:20694152 + @@ -93843,8 +138341,19 @@ + The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts. apical ectodermal ridge formation + + + + The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts. + GOC:TermGenie + GO_REF:0000081 + PMID:18359901 + PMID:9323126 + PMID:9596583 + @@ -93869,8 +138378,17 @@ + Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation. regulation of apical ectodermal ridge formation + + + + Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation. + GOC:TermGenie + GO_REF:0000058 + PMID:18359901 + @@ -93897,8 +138415,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation. negative regulation of apical ectodermal ridge formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation. + GOC:TermGenie + GO_REF:0000058 + PMID:18359901 + @@ -93925,8 +138452,55 @@ + Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation. positive regulation of apical ectodermal ridge formation + + + + Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation. + GOC:TermGenie + GO_REF:0000058 + PMID:18359901 + + + + + + + + + + + + + + + + + + + + + + + + + + Any cellular protein catabolic process that takes place in a lysosome. + Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants. + lysosomal protein catabolic process + + + + + Any cellular protein catabolic process that takes place in a lysosome. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000062 + PMID:24334770 + @@ -93952,8 +138526,20 @@ + Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy. regulation of smooth muscle hypertrophy + + + + Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:22161164 + @@ -93980,8 +138566,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy. negative regulation of smooth muscle hypertrophy + + + + Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:22161164 + @@ -94008,8 +138606,20 @@ + Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy. positive regulation of smooth muscle hypertrophy + + + + Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:22161164 + @@ -94034,8 +138644,19 @@ + Any process that modulates the frequency, rate or extent of membrane invagination. regulation of membrane invagination + + + + Any process that modulates the frequency, rate or extent of membrane invagination. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:26589353 + @@ -94061,8 +138682,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination. negative regulation of membrane invagination + + + + Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:26589353 + @@ -94088,8 +138720,129 @@ + Any process that activates or increases the frequency, rate or extent of membrane invagination. positive regulation of membrane invagination + + + + Any process that activates or increases the frequency, rate or extent of membrane invagination. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process. + regulation of lysosomal protein catabolic process + + + + + Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:23499937 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process. + negative regulation of lysosomal protein catabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process. + positive regulation of lysosomal protein catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + @@ -94114,8 +138867,20 @@ + Any process that modulates the frequency, rate or extent of cardiocyte differentiation. regulation of cardiocyte differentiation + + + + Any process that modulates the frequency, rate or extent of cardiocyte differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23069713 + @@ -94142,8 +138907,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. negative regulation of cardiocyte differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23069713 + @@ -94170,8 +138947,20 @@ + Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation. positive regulation of cardiocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23069713 + @@ -94198,8 +138987,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation. negative regulation of mitotic chromosome condensation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation. + GOC:TermGenie + GO_REF:0000058 + PMID:23219725 + @@ -94224,8 +139022,19 @@ + The developmental process by which an epicardium is generated and organized. epicardium morphogenesis + + + + The developmental process by which an epicardium is generated and organized. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000083 + PMID:18718461 + @@ -94251,8 +139060,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization. negative regulation of chromatin organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization. + GOC:TermGenie + GOC:pr + GOC:vw + GO_REF:0000058 + PMID:654321 + @@ -94278,8 +139098,19 @@ + Any process that activates or increases the frequency, rate or extent of chromatin organization. positive regulation of chromatin organization + + + + Any process that activates or increases the frequency, rate or extent of chromatin organization. + GOC:TermGenie + GOC:pr + GOC:vw + GO_REF:0000058 + PMID:654321 + @@ -94305,8 +139136,19 @@ + Any process that modulates the frequency, rate or extent of epithelial tube formation. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). regulation of epithelial tube formation + + + + Any process that modulates the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94333,8 +139175,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). negative regulation of epithelial tube formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94361,8 +139214,19 @@ + Any process that activates or increases the frequency, rate or extent of epithelial tube formation. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). positive regulation of epithelial tube formation + + + + Any process that activates or increases the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94387,8 +139251,20 @@ + Any apoptotic process in a vascular associated smooth muscle cell. vascular associated smooth muscle cell apoptotic process + + + + Any apoptotic process in a vascular associated smooth muscle cell. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000085 + PMID:26493107 + @@ -94413,8 +139289,19 @@ + Any process that modulates the frequency, rate or extent of neural crest cell differentiation. regulation of neural crest cell differentiation + + + + Any process that modulates the frequency, rate or extent of neural crest cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:15073157 + @@ -94441,8 +139328,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation. negative regulation of neural crest cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:15073157 + @@ -94469,8 +139367,139 @@ + Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation. positive regulation of neural crest cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:15073157 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of intestinal epithelial cell development. + regulation of intestinal epithelial cell development + + + + + Any process that modulates the frequency, rate or extent of intestinal epithelial cell development. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23904268 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development. + negative regulation of intestinal epithelial cell development + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23904268 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development. + positive regulation of intestinal epithelial cell development + + + + + Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23904268 + @@ -94497,8 +139526,19 @@ + Any process that modulates the frequency, rate or extent of cardiac myofibril assembly. regulation of cardiac myofibril assembly + + + + Any process that modulates the frequency, rate or extent of cardiac myofibril assembly. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:16151019 + @@ -94526,8 +139566,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly. negative regulation of cardiac myofibril assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:16151019 + @@ -94555,8 +139606,19 @@ + Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly. positive regulation of cardiac myofibril assembly + + + + Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:16151019 + @@ -94581,8 +139643,19 @@ + Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis + + + + Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:17628518 + @@ -94608,8 +139681,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:17628518 + @@ -94635,8 +139719,19 @@ + Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:17628518 + @@ -94661,8 +139756,19 @@ + Any cell proliferation that is involved in endocardial cushion morphogenesis. cell proliferation involved in endocardial cushion morphogenesis + + + + Any cell proliferation that is involved in endocardial cushion morphogenesis. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000060 + PMID:20652948 + @@ -94687,8 +139793,18 @@ + The orderly movement of a mesenchymal stem cell from one site to another. mesenchymal stem cell migration + + + + The orderly movement of a mesenchymal stem cell from one site to another. + GOC:TermGenie + GO_REF:0000091 + PMID:24924806 + PMID:25181476 + @@ -94713,8 +139829,17 @@ + Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration. regulation of mesenchymal stem cell migration + + + + Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration. + GOC:TermGenie + GO_REF:0000058 + PMID:26846297 + @@ -94740,8 +139865,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration. negative regulation of mesenchymal stem cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration. + GOC:TermGenie + GO_REF:0000058 + PMID:26846297 + @@ -94767,8 +139901,17 @@ + Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration. positive regulation of mesenchymal stem cell migration + + + + Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration. + GOC:TermGenie + GO_REF:0000058 + PMID:26846297 + @@ -94793,8 +139936,19 @@ + Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). regulation of morphogenesis of an epithelium + + + + Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94820,8 +139974,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). negative regulation of morphogenesis of an epithelium + + + + Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94847,8 +140012,19 @@ + Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). positive regulation of morphogenesis of an epithelium + + + + Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94879,8 +140055,22 @@ + The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone. ciliary transition zone assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone. + GOC:TermGenie + GOC:cilia + GO_REF:0000079 + PMID:21725307 + PMID:23644468 + PMID:24448408 + PMID:26595381 + PMID:26982032 + @@ -94905,8 +140095,20 @@ + The orderly movement of a pericyte cell from one site to another. pericyte cell migration + + + + The orderly movement of a pericyte cell from one site to another. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000091 + PMID:26268439 + @@ -94931,8 +140133,17 @@ + A process in which a protein is transported to, or maintained in, a location within a presynapse. protein localization to presynapse + + + + A process in which a protein is transported to, or maintained in, a location within a presynapse. + GOC:TermGenie + GO_REF:0000087 + PMID:24449494 + @@ -94957,8 +140168,19 @@ + Any process that modulates the frequency, rate or extent of protein localization to presynapse. regulation of protein localization to presynapse + + + + Any process that modulates the frequency, rate or extent of protein localization to presynapse. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:24449494 + @@ -94984,8 +140206,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse. negative regulation of protein localization to presynapse + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:24449494 + @@ -95011,8 +140244,19 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to presynapse. positive regulation of protein localization to presynapse + + + + Any process that activates or increases the frequency, rate or extent of protein localization to presynapse. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:24449494 + @@ -95037,8 +140281,19 @@ + Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. regulation of retrograde trans-synaptic signaling by neuropeptide + + + + Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:19448629 + @@ -95065,8 +140320,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. negative regulation of retrograde trans-synaptic signaling by neuropeptide + + + + Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:19448629 + @@ -95093,8 +140359,19 @@ + Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. positive regulation of retrograde trans-synaptic signaling by neuropeptide + + + + Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:19448629 + @@ -95119,8 +140396,17 @@ + Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation. regulation of myeloid progenitor cell differentiation + + + + Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95146,8 +140432,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation. negative regulation of myeloid progenitor cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95173,8 +140468,17 @@ + Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation. positive regulation of myeloid progenitor cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95199,8 +140503,17 @@ + Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation. regulation of lymphoid progenitor cell differentiation + + + + Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95226,8 +140539,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation. negative regulation of lymphoid progenitor cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95253,8 +140575,17 @@ + Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation. positive regulation of lymphoid progenitor cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95279,8 +140610,20 @@ + Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. regulation of vascular associated smooth muscle cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:26493107 + @@ -95306,8 +140649,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. negative regulation of vascular associated smooth muscle cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:26493107 + @@ -95333,8 +140688,20 @@ + Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. positive regulation of vascular associated smooth muscle cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:26493107 + @@ -95359,8 +140726,19 @@ + Any process that modulates the frequency, rate or extent of protein localization to membrane. regulation of protein localization to membrane + + + + Any process that modulates the frequency, rate or extent of protein localization to membrane. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:26911690 + @@ -95386,8 +140764,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane. negative regulation of protein localization to membrane + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:26911690 + @@ -95413,8 +140802,19 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to membrane. positive regulation of protein localization to membrane + + + + Any process that activates or increases the frequency, rate or extent of protein localization to membrane. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:26911690 + @@ -95439,8 +140839,17 @@ + Any process that modulates the frequency, rate or extent of motor neuron migration. regulation of motor neuron migration + + + + Any process that modulates the frequency, rate or extent of motor neuron migration. + GOC:TermGenie + GO_REF:0000058 + PMID:16516839 + @@ -95466,8 +140875,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration. negative regulation of motor neuron migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration. + GOC:TermGenie + GO_REF:0000058 + PMID:16516839 + @@ -95493,8 +140911,17 @@ + Any process that activates or increases the frequency, rate or extent of motor neuron migration. positive regulation of motor neuron migration + + + + Any process that activates or increases the frequency, rate or extent of motor neuron migration. + GOC:TermGenie + GO_REF:0000058 + PMID:16516839 + @@ -95521,8 +140948,17 @@ + Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve. positive regulation of branching morphogenesis of a nerve + + + + Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve. + GOC:TermGenie + GO_REF:0000058 + PMID:16516839 + @@ -95547,8 +140983,19 @@ + Any process that modulates the frequency, rate or extent of motile cilium assembly. regulation of motile cilium assembly + + + + Any process that modulates the frequency, rate or extent of motile cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:25294941 + @@ -95574,8 +141021,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly. negative regulation of motile cilium assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:25294941 + @@ -95601,8 +141059,19 @@ + Any process that activates or increases the frequency, rate or extent of motile cilium assembly. positive regulation of motile cilium assembly + + + + Any process that activates or increases the frequency, rate or extent of motile cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:25294941 + @@ -95628,8 +141097,18 @@ + Any process that activates or increases the frequency, rate or extent of fertilization. positive regulation of fertilization + + + + Any process that activates or increases the frequency, rate or extent of fertilization. + GOC:TermGenie + GOC:hbye + GO_REF:0000058 + PMID:27564576 + @@ -95655,8 +141134,17 @@ + The orderly movement of a macrophage from one site to another. macrophage migration + + + + The orderly movement of a macrophage from one site to another. + GOC:TermGenie + GO_REF:0000091 + PMID:25749876 + @@ -95681,8 +141169,17 @@ + Any process that modulates the frequency, rate or extent of macrophage migration. regulation of macrophage migration + + + + Any process that modulates the frequency, rate or extent of macrophage migration. + GOC:TermGenie + GO_REF:0000058 + PMID:25749876 + @@ -95708,8 +141205,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration. negative regulation of macrophage migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration. + GOC:TermGenie + GO_REF:0000058 + PMID:25749876 + @@ -95735,8 +141241,17 @@ + Any process that activates or increases the frequency, rate or extent of macrophage migration. positive regulation of macrophage migration + + + + Any process that activates or increases the frequency, rate or extent of macrophage migration. + GOC:TermGenie + GO_REF:0000058 + PMID:25749876 + @@ -95763,8 +141278,20 @@ + Any process that modulates the frequency, rate or extent of blood vessel branching. regulation of blood vessel branching + + + + Any process that modulates the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -95791,8 +141318,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. negative regulation of vessel branching + + + + Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -95819,8 +141358,20 @@ + Any process that activates or increases the frequency, rate or extent of blood vessel branching. positive regulation of blood vessel branching + + + + Any process that activates or increases the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -95846,8 +141397,17 @@ + Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly. regulation of mitotic nuclear envelope disassembly + + + + Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly. + GOC:TermGenie + GO_REF:0000058 + PMID:18765790 + @@ -95874,8 +141434,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly. negative regulation of mitotic nuclear envelope disassembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly. + GOC:TermGenie + GO_REF:0000058 + PMID:18765790 + @@ -95902,8 +141471,17 @@ + Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly. positive regulation of mitotic nuclear envelope disassembly + + + + Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly. + GOC:TermGenie + GO_REF:0000058 + PMID:18765790 + @@ -95928,8 +141506,20 @@ + Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation. regulation of vascular endothelial cell proliferation + + + + Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -95955,8 +141545,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. negative regulation of vascular endothelial cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -95982,8 +141584,20 @@ + Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. positive regulation of vascular endothelial cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -96008,8 +141622,19 @@ + Any process that modulates the frequency, rate or extent of presynapse assembly. regulation of presynapse assembly + + + + Any process that modulates the frequency, rate or extent of presynapse assembly. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:25533483 + @@ -96035,8 +141660,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly. negative regulation of presynapse assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:25533483 + @@ -96062,8 +141698,19 @@ + Any process that activates or increases the frequency, rate or extent of presynapse assembly. positive regulation of presynapse assembly + + + + Any process that activates or increases the frequency, rate or extent of presynapse assembly. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:25533483 + @@ -96088,8 +141735,19 @@ + Any process that modulates the frequency, rate or extent of serotonin biosynthetic process. regulation of serotonin biosynthetic process + + + + Any process that modulates the frequency, rate or extent of serotonin biosynthetic process. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:25642596 + @@ -96115,8 +141773,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process. negative regulation of serotonin biosynthetic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:25642596 + @@ -96142,8 +141811,19 @@ + Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process. positive regulation of serotonin biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:25642596 + @@ -96168,8 +141848,17 @@ + A process in which a protein is transported to, or maintained in, a location within an euchromatin. protein localization to euchromatin + + + + A process in which a protein is transported to, or maintained in, a location within an euchromatin. + GOC:TermGenie + GO_REF:0000087 + PMID:20889714 + @@ -96189,8 +141878,17 @@ + The directed movement of a protein to a specific location in an euchromatin. establishment of protein localization to euchromatin + + + + The directed movement of a protein to a specific location in an euchromatin. + GOC:TermGenie + GO_REF:0000087 + PMID:20889714 + @@ -96215,8 +141913,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to chromatin. regulation of protein localization to chromatin + + + + Any process that modulates the frequency, rate or extent of protein localization to chromatin. + GOC:TermGenie + GO_REF:0000058 + PMID:20889714 + @@ -96241,8 +141948,20 @@ + Any process that modulates the frequency, rate or extent of artery morphogenesis. regulation of artery morphogenesis + + + + Any process that modulates the frequency, rate or extent of artery morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:27389411 + @@ -96268,8 +141987,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis. negative regulation of artery morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:27389411 + @@ -96295,8 +142026,20 @@ + Any process that activates or increases the frequency, rate or extent of artery morphogenesis. positive regulation of artery morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of artery morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:27389411 + @@ -96321,8 +142064,17 @@ + Any process that modulates the frequency, rate or extent of lysosome organization. regulation of lysosome organization + + + + Any process that modulates the frequency, rate or extent of lysosome organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25561470 + @@ -96348,8 +142100,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization. negative regulation of lysosome organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25561470 + @@ -96375,8 +142136,17 @@ + Any process that activates or increases the frequency, rate or extent of lysosome organization. positive regulation of lysosome organization + + + + Any process that activates or increases the frequency, rate or extent of lysosome organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25561470 + @@ -96401,8 +142171,18 @@ + The disaggregation of a nucleus into its constituent components. nucleus disassembly + + + + The disaggregation of a nucleus into its constituent components. + GOC:TermGenie + GOC:autophagy + GOC:pr + GO_REF:0000079 + @@ -96427,8 +142207,18 @@ + Any microtubule bundle that is part of a cytoplasm. cytoplasmic microtubule bundle + + + + Any microtubule bundle that is part of a cytoplasm. + GOC:TermGenie + GO_REF:0000064 + PMID:11007487 + PMID:26124291 + @@ -96453,8 +142243,17 @@ + A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule. protein localization to cytoplasmic microtubule + + + + A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule. + GOC:TermGenie + GO_REF:0000087 + PMID:15177031 + @@ -96479,8 +142278,20 @@ + Any process that modulates the frequency, rate or extent of mesodermal cell differentiation. regulation of mesodermal cell differentiation + + + + Any process that modulates the frequency, rate or extent of mesodermal cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23765923 + @@ -96506,8 +142317,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation. negative regulation of mesodermal cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23765923 + @@ -96533,8 +142356,20 @@ + Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation. positive regulation of mesodermal cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23765923 + @@ -96559,8 +142394,17 @@ + Any process that modulates the frequency, rate or extent of synapse pruning. regulation of synapse pruning + + + + Any process that modulates the frequency, rate or extent of synapse pruning. + GOC:TermGenie + GO_REF:0000058 + PMID:27779093 + @@ -96586,8 +142430,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning. negative regulation of synapse pruning + + + + Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning. + GOC:TermGenie + GO_REF:0000058 + PMID:27779093 + @@ -96613,8 +142466,17 @@ + Any process that activates or increases the frequency, rate or extent of synapse pruning. positive regulation of synapse pruning + + + + Any process that activates or increases the frequency, rate or extent of synapse pruning. + GOC:TermGenie + GO_REF:0000058 + PMID:27779093 + @@ -96640,8 +142502,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization. negative regulation of synapse organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization. + GOC:TermGenie + GO_REF:0000058 + PMID:27779093 + @@ -96667,8 +142538,18 @@ + Any process that activates or increases the frequency, rate or extent of chromosome condensation. positive regulation of chromosome condensation + + + + Any process that activates or increases the frequency, rate or extent of chromosome condensation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:17268547 + @@ -96694,8 +142575,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation. negative regulation of microtubule nucleation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation. + GOC:TermGenie + GO_REF:0000058 + PMID:27689799 + @@ -96720,8 +142610,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to cell leading edge. regulation of protein localization to cell leading edge + + + + Any process that modulates the frequency, rate or extent of protein localization to cell leading edge. + GOC:TermGenie + GO_REF:0000058 + PMID:26324884 + @@ -96747,8 +142646,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge. negative regulation of protein localization to cell leading edge + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge. + GOC:TermGenie + GO_REF:0000058 + PMID:26324884 + @@ -96774,8 +142682,17 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge. positive regulation of protein localization to cell leading edge + + + + Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge. + GOC:TermGenie + GO_REF:0000058 + PMID:26324884 + @@ -96802,8 +142719,17 @@ + Any process that modulates the frequency, rate or extent of oogenesis. regulation of oogenesis + + + + Any process that modulates the frequency, rate or extent of oogenesis. + GOC:TermGenie + GO_REF:0000058 + PMID:26434723 + @@ -96831,8 +142757,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. negative regulation of oogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. + GOC:TermGenie + GO_REF:0000058 + PMID:26434723 + @@ -96860,8 +142795,17 @@ + Any process that activates or increases the frequency, rate or extent of oogenesis. positive regulation of oogenesis + + + + Any process that activates or increases the frequency, rate or extent of oogenesis. + GOC:TermGenie + GO_REF:0000058 + PMID:26434723 + @@ -96886,8 +142830,18 @@ + Any process that modulates the frequency, rate or extent of smooth muscle tissue development. regulation of smooth muscle tissue development + + + + Any process that modulates the frequency, rate or extent of smooth muscle tissue development. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:14709716 + @@ -96913,8 +142867,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development. negative regulation of smooth muscle tissue development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:14709716 + @@ -96940,8 +142904,18 @@ + Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development. positive regulation of smooth muscle tissue development + + + + Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:14709716 + @@ -96966,8 +142940,20 @@ + Any process that modulates the frequency, rate or extent of mesoderm formation. regulation of mesoderm formation + + + + Any process that modulates the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 + @@ -96993,8 +142979,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. negative regulation of mesoderm formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 + @@ -97020,8 +143018,20 @@ + Any process that activates or increases the frequency, rate or extent of mesoderm formation. positive regulation of mesoderm formation + + + + Any process that activates or increases the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 + @@ -97047,8 +143057,17 @@ + Any process that modulates the frequency, rate or extent of germ cell proliferation. regulation of germ cell proliferation + + + + Any process that modulates the frequency, rate or extent of germ cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97075,8 +143094,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation. negative regulation of germ cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97103,8 +143131,17 @@ + Any process that activates or increases the frequency, rate or extent of germ cell proliferation. positive regulation of germ cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of germ cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97130,8 +143167,17 @@ + Any process that modulates the frequency, rate or extent of gonad development. regulation of gonad development + + + + Any process that modulates the frequency, rate or extent of gonad development. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97159,8 +143205,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. negative regulation of gonad development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97188,8 +143243,17 @@ + Any process that activates or increases the frequency, rate or extent of gonad development. positive regulation of gonad development + + + + Any process that activates or increases the frequency, rate or extent of gonad development. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97214,8 +143278,17 @@ + Any process that modulates the frequency, rate or extent of lipid localization. regulation of lipid localization + + + + Any process that modulates the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 + @@ -97241,8 +143314,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. negative regulation of lipid localization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 + @@ -97268,8 +143350,17 @@ + Any process that activates or increases the frequency, rate or extent of lipid localization. positive regulation of lipid localization + + + + Any process that activates or increases the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 + @@ -97296,8 +143387,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis. negative regulation of endothelial tube morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:25961718 + @@ -97324,8 +143427,20 @@ + Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis. positive regulation of endothelial tube morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:25961718 + @@ -97350,8 +143465,17 @@ + Any apoptotic process in a retinal cell. retinal cell apoptotic process + + + + Any apoptotic process in a retinal cell. + GOC:mtg_apoptosis + PMID:15558487 + PMID:24664675 + @@ -97376,8 +143500,16 @@ + Any apoptotic process in a compound eye retinal cell. compound eye retinal cell apoptotic process + + + + Any apoptotic process in a compound eye retinal cell. + GOC:mtg_apoptosis + PMID:12021768 + @@ -97435,8 +143567,19 @@ + The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. exosomal secretion + + + + The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. + GOC:hjd + PMID:10572093 + PMID:12154376 + PMID:16773132 + PMID:18617898 + @@ -97461,8 +143604,52 @@ + A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin. RNA localization to chromatin + + + + A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin. + GOC:dos + GOC:mah + PMID:22582262 + + + + + + + + + + + + + + + + + + + + + + + + + + A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. + An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). + transporter complex + + + + + A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. + GOC:bhm + PMID:15449578 + @@ -97487,8 +143674,140 @@ + Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis. dense core granule maturation + + + + Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis. + GOC:kmv + PMID:22654674 + + + + + + + + + + + + + + + + + + + + + + + + + + The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. + cholangiocyte proliferation + + + + + The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. + PMID:24434010 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. + cellular detoxification + + + + + Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum. + colon smooth muscle contraction + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum. + PMID:24170253 + @@ -97513,8 +143832,66 @@ + The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. gastric mucosal blood circulation + + + + The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. + PMID:10807413 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. + small intestine smooth muscle contraction + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. + PMID:11991626 + @@ -97539,8 +143916,15 @@ + A process in which a protein is transported to, or maintained in, the cell periphery. protein localization to cell periphery + + + + A process in which a protein is transported to, or maintained in, the cell periphery. + PMID:18216290 + @@ -97565,8 +143949,48 @@ + Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell. vacuolar localization + + + + Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell. + PMID:26283797 + + + + + + + + + + + + + + + + + + + + + + + + + + The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus). + acinar cell proliferation + + + + + The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus). + PMID:9788538 + @@ -97591,8 +144015,15 @@ + The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. vascular associated smooth muscle cell proliferation + + + + The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. + PMID:23246467 + @@ -97606,8 +144037,17 @@ + A macromolecular complex that contains both RNA and protein molecules. + Wikipedia:Ribonucleoprotein ribonucleoprotein complex + + + + A macromolecular complex that contains both RNA and protein molecules. + GOC:krc + GOC:vesicles + @@ -97658,8 +144098,15 @@ + The cytoplasm of an ovum. ooplasm + + + + The cytoplasm of an ovum. + PMID:19022436 + @@ -97685,8 +144132,15 @@ + Any process that modulates the frequency, rate or extent of multicellular organismal development. regulation of multicellular organismal development + + + + Any process that modulates the frequency, rate or extent of multicellular organismal development. + GOC:obol + @@ -97711,8 +144165,15 @@ + Any process that modulates the frequency, rate or extent of animal organ morphogenesis. regulation of animal organ morphogenesis + + + + Any process that modulates the frequency, rate or extent of animal organ morphogenesis. + GOC:obol + @@ -97737,8 +144198,15 @@ + Any process that modulates the frequency, rate or extent of stem cell division. regulation of stem cell division + + + + Any process that modulates the frequency, rate or extent of stem cell division. + GOC:obol + @@ -97763,8 +144231,122 @@ + Any process that modulates the frequency, rate or extent of defense response to insect. regulation of defense response to insect + + + + Any process that modulates the frequency, rate or extent of defense response to insect. + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of pancreatic B cell development. + regulation of type B pancreatic cell development + + + + + Any process that modulates the frequency, rate or extent of pancreatic B cell development. + GOC:obol + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. + negative regulation of type B pancreatic cell development + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. + GOC:obol + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. + positive regulation of type B pancreatic cell development + + + + + Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. + GOC:obol + GOC:yaf + @@ -97789,8 +144371,16 @@ + Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. regulation of leukocyte apoptotic process + + + + Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97816,8 +144406,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. negative regulation of leukocyte apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97843,8 +144441,16 @@ + Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. positive regulation of leukocyte apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97870,8 +144476,16 @@ + Any process that modulates the frequency, rate or extent of macrophage apoptotic process. regulation of macrophage apoptotic process + + + + Any process that modulates the frequency, rate or extent of macrophage apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97898,8 +144512,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process. negative regulation of macrophage apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97926,8 +144548,16 @@ + Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process. positive regulation of macrophage apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97952,8 +144582,15 @@ + Any process that modulates the frequency, rate or extent of establishment of cell polarity. regulation of establishment of cell polarity + + + + Any process that modulates the frequency, rate or extent of establishment of cell polarity. + GOC:dph + @@ -97978,8 +144615,15 @@ + Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. regulation of cell proliferation involved in heart morphogenesis + + + + Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. + GOC:dph + @@ -98005,8 +144649,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis. negative regulation of cell proliferation involved in heart morphogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis. + GOC:dph + @@ -98032,8 +144683,15 @@ + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. positive regulation of cell proliferation involved in heart morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. + GOC:dph + @@ -98059,8 +144717,15 @@ + Any process that modulates the frequency, rate or extent of cell motility. regulation of cell motility + + + + Any process that modulates the frequency, rate or extent of cell motility. + GOC:mah + @@ -98087,8 +144752,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. negative regulation of cell motility + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. + GOC:mah + @@ -98115,8 +144787,15 @@ + Any process that activates or increases the frequency, rate or extent of cell motility. positive regulation of cell motility + + + + Any process that activates or increases the frequency, rate or extent of cell motility. + GOC:mah + @@ -98142,8 +144821,16 @@ + Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility. positive regulation of cilium-dependent cell motility + + + + Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility. + GOC:cilia + GOC:jl + @@ -98168,8 +144855,15 @@ + Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve. regulation of branching morphogenesis of a nerve + + + + Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve. + GOC:BHF + @@ -98196,8 +144890,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve. negative regulation of branching morphogenesis of a nerve + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve. + GOC:BHF + @@ -98223,8 +144924,15 @@ + Any process that modulates the frequency, rate or extent of pro-T cell differentiation. regulation of pro-T cell differentiation + + + + Any process that modulates the frequency, rate or extent of pro-T cell differentiation. + GOC:BHF + @@ -98251,8 +144959,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation. negative regulation of pro-T cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation. + GOC:BHF + @@ -98279,8 +144994,15 @@ + Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation. positive regulation of pro-T cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation. + GOC:BHF + @@ -98305,8 +145027,16 @@ + Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. regulation of neural precursor cell proliferation + + + + Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. + GOC:dph + GOC:yaf + @@ -98332,8 +145062,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. negative regulation of neural precursor cell proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. + GOC:dph + GOC:yaf + @@ -98359,8 +145097,16 @@ + Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. positive regulation of neural precursor cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. + GOC:dph + GOC:yaf + @@ -98386,8 +145132,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. negative regulation of blood vessel morphogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. + GOC:dph + GOC:yaf + @@ -98413,8 +145167,15 @@ + Any process that modulates the frequency, rate or extent of female gonad development. regulation of female gonad development + + + + Any process that modulates the frequency, rate or extent of female gonad development. + GOC:obol + @@ -98440,8 +145201,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. negative regulation of female gonad development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. + GOC:obol + @@ -98467,8 +145235,118 @@ + Any process that activates or increases the frequency, rate or extent of female gonad development. positive regulation of female gonad development + + + + Any process that activates or increases the frequency, rate or extent of female gonad development. + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation. + regulation of pancreatic A cell differentiation + + + + + Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation. + negative regulation of pancreatic A cell differentiation + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation. + positive regulation of pancreatic A cell differentiation + + + + + Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation. + GOC:mah + @@ -98493,8 +145371,15 @@ + Any process that modulates the frequency, rate or extent of reproductive process. regulation of reproductive process + + + + Any process that modulates the frequency, rate or extent of reproductive process. + GOC:mah + @@ -98520,8 +145405,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. negative regulation of reproductive process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. + GOC:mah + @@ -98547,8 +145439,15 @@ + Any process that activates or increases the frequency, rate or extent of reproductive process. positive regulation of reproductive process + + + + Any process that activates or increases the frequency, rate or extent of reproductive process. + GOC:mah + @@ -98575,8 +145474,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity. negative regulation of establishment or maintenance of neuroblast polarity + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity. + GOC:obol + @@ -98601,8 +145507,17 @@ + Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. regulation of fibroblast apoptotic process + + + + Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. + GOC:mtg_apoptosis + GOC:obol + GOC:yaf + @@ -98628,8 +145543,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. negative regulation of fibroblast apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. + GOC:mtg_apoptosis + GOC:obol + GOC:yaf + @@ -98655,8 +145579,17 @@ + Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process. positive regulation of fibroblast apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process. + GOC:mtg_apoptosis + GOC:obol + GOC:yaf + @@ -98681,8 +145614,15 @@ + Any process that modulates the frequency, rate or extent of DNA biosynthetic process. regulation of DNA biosynthetic process + + + + Any process that modulates the frequency, rate or extent of DNA biosynthetic process. + GOC:obol + @@ -98708,8 +145648,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. negative regulation of DNA biosynthetic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. + GOC:obol + @@ -98735,8 +145682,15 @@ + Any process that activates or increases the frequency, rate or extent of myotome development. positive regulation of myotome development + + + + Any process that activates or increases the frequency, rate or extent of myotome development. + GOC:BHF + @@ -98762,8 +145716,15 @@ + Any process that activates or increases the frequency, rate or extent of myoblast proliferation. positive regulation of myoblast proliferation + + + + Any process that activates or increases the frequency, rate or extent of myoblast proliferation. + GOC:BHF + @@ -98788,8 +145749,15 @@ + Any process that modulates the frequency, rate or extent of myotome development. regulation of myotome development + + + + Any process that modulates the frequency, rate or extent of myotome development. + GOC:mah + @@ -98814,8 +145782,119 @@ + Any process that modulates the frequency, rate or extent of myoblast proliferation. regulation of myoblast proliferation + + + + Any process that modulates the frequency, rate or extent of myoblast proliferation. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of defecation. + regulation of defecation + + + + + Any process that modulates the frequency, rate or extent of defecation. + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of defecation. + negative regulation of defecation + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of defecation. + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of defecation. + positive regulation of defecation + + + + + Any process that activates or increases the frequency, rate or extent of defecation. + GOC:obol + @@ -98840,8 +145919,16 @@ + Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. regulation of endothelial cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. + GOC:mah + GOC:mtg_apoptosis + @@ -98867,8 +145954,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. negative regulation of endothelial cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + @@ -98894,8 +145990,17 @@ + Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. positive regulation of endothelial cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + @@ -98920,8 +146025,15 @@ + Any process that modulates the frequency, rate or extent of oxygen metabolic process. regulation of oxygen metabolic process + + + + Any process that modulates the frequency, rate or extent of oxygen metabolic process. + GOC:mah + @@ -98947,8 +146059,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process. negative regulation of oxygen metabolic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process. + GOC:mah + @@ -98974,8 +146093,15 @@ + Any process that activates or increases the frequency, rate or extent of oxygen metabolic process. positive regulation of oxygen metabolic process + + + + Any process that activates or increases the frequency, rate or extent of oxygen metabolic process. + GOC:mah + @@ -99000,8 +146126,15 @@ + Any process that modulates the frequency, rate or extent of mesoderm development. regulation of mesoderm development + + + + Any process that modulates the frequency, rate or extent of mesoderm development. + GOC:BHF + @@ -99027,8 +146160,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. negative regulation of mesoderm development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. + GOC:BHF + @@ -99054,8 +146194,15 @@ + Any process that activates or increases the frequency, rate or extent of mesoderm development. positive regulation of mesoderm development + + + + Any process that activates or increases the frequency, rate or extent of mesoderm development. + GOC:BHF + @@ -99080,8 +146227,15 @@ + Any process that modulates the frequency, rate or extent of ectoderm development. regulation of ectoderm development + + + + Any process that modulates the frequency, rate or extent of ectoderm development. + GOC:BHF + @@ -99107,8 +146261,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. negative regulation of ectoderm development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. + GOC:BHF + @@ -99134,8 +146295,15 @@ + Any process that activates or increases the frequency, rate or extent of ectoderm development. positive regulation of ectoderm development + + + + Any process that activates or increases the frequency, rate or extent of ectoderm development. + GOC:BHF + @@ -99160,8 +146328,15 @@ + Any process that modulates the frequency, rate or extent of lymphocyte migration. regulation of lymphocyte migration + + + + Any process that modulates the frequency, rate or extent of lymphocyte migration. + GOC:mah + @@ -99187,8 +146362,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration. negative regulation of lymphocyte migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration. + GOC:mah + @@ -99214,8 +146396,15 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte migration. positive regulation of lymphocyte migration + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte migration. + GOC:mah + @@ -99240,8 +146429,15 @@ + Any process that modulates the frequency, rate or extent of T cell migration. regulation of T cell migration + + + + Any process that modulates the frequency, rate or extent of T cell migration. + GOC:mah + @@ -99267,8 +146463,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration. negative regulation of T cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration. + GOC:mah + @@ -99294,8 +146497,15 @@ + Any process that activates or increases the frequency, rate or extent of T cell migration. positive regulation of T cell migration + + + + Any process that activates or increases the frequency, rate or extent of T cell migration. + GOC:mah + @@ -99320,8 +146530,15 @@ + Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration. regulation of hematopoietic stem cell migration + + + + Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration. + GOC:obol + @@ -99347,8 +146564,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration. negative regulation of hematopoietic stem cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration. + GOC:obol + @@ -99374,8 +146598,15 @@ + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration. positive regulation of hematopoietic stem cell migration + + + + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration. + GOC:obol + @@ -99400,8 +146631,15 @@ + Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. regulation of cell proliferation involved in compound eye morphogenesis + + + + Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. + GOC:obol + @@ -99427,8 +146665,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. negative regulation of cell proliferation involved in compound eye morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. + GOC:obol + @@ -99454,8 +146699,15 @@ + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. positive regulation of cell proliferation involved in compound eye morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. + GOC:obol + @@ -99481,8 +146733,15 @@ + Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis. regulation of dendritic cell chemotaxis + + + + Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis. + GOC:obol + @@ -99509,8 +146768,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis. negative regulation of dendritic cell chemotaxis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis. + GOC:obol + @@ -99537,8 +146803,15 @@ + Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis. positive regulation of dendritic cell chemotaxis + + + + Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis. + GOC:obol + @@ -99563,8 +146836,15 @@ + Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis. regulation of myeloid dendritic cell chemotaxis + + + + Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis. + GOC:obol + @@ -99590,8 +146870,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis. negative regulation of myeloid dendritic cell chemotaxis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis. + GOC:obol + @@ -99617,8 +146904,15 @@ + Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis. positive regulation of myeloid dendritic cell chemotaxis + + + + Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis. + GOC:obol + @@ -99644,8 +146938,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. negative regulation of gastrulation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. + GOC:obol + @@ -99671,8 +146972,15 @@ + Any process that activates or increases the frequency, rate or extent of gastrulation. positive regulation of gastrulation + + + + Any process that activates or increases the frequency, rate or extent of gastrulation. + GOC:obol + @@ -99697,8 +147005,15 @@ + Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly. regulation of dendritic cell dendrite assembly + + + + Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly. + GOC:obol + @@ -99724,8 +147039,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly. negative regulation of dendritic cell dendrite assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly. + GOC:obol + @@ -99751,8 +147073,15 @@ + Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly. positive regulation of dendritic cell dendrite assembly + + + + Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly. + GOC:obol + @@ -99778,8 +147107,15 @@ + Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. positive regulation of DNA biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. + GOC:obol + @@ -99805,8 +147141,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. negative regulation of stem cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. + GOC:dph + @@ -99832,8 +147175,15 @@ + Any process that activates or increases the frequency, rate or extent of stem cell proliferation. positive regulation of stem cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of stem cell proliferation. + GOC:dph + @@ -99858,8 +147208,16 @@ + Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process. regulation of dendritic cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -99885,8 +147243,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process. negative regulation of dendritic cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -99912,8 +147278,16 @@ + Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process. positive regulation of dendritic cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -99938,8 +147312,16 @@ + Any process that modulates the frequency, rate or extent of motor neuron apoptotic process. regulation of motor neuron apoptotic process + + + + Any process that modulates the frequency, rate or extent of motor neuron apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -99965,8 +147347,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process. negative regulation of motor neuron apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -99992,8 +147382,120 @@ + Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process. positive regulation of motor neuron apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process. + GOC:mtg_apoptosis + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process. + regulation of type B pancreatic cell apoptotic process + + + + + Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process. + negative regulation of type B pancreatic cell apoptotic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process. + positive regulation of type B pancreatic cell apoptotic process + + + + + Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -100019,8 +147521,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation. regulation of cardiac muscle cell myoblast differentiation + + + + Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation. + GOC:obol + @@ -100047,8 +147556,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation. negative regulation of cardiac muscle cell myoblast differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation. + GOC:obol + @@ -100075,8 +147591,15 @@ + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation. positive regulation of cardiac muscle cell myoblast differentiation + + + + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation. + GOC:obol + @@ -100102,8 +147625,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. regulation of cardiac muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. + GOC:BHF + @@ -100130,8 +147660,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. negative regulation of cardiac muscle cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. + GOC:BHF + @@ -100158,8 +147695,15 @@ + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. positive regulation of cardiac muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. + GOC:BHF + @@ -100184,8 +147728,15 @@ + Any process that modulates the frequency, rate or extent of stem cell differentiation. regulation of stem cell differentiation + + + + Any process that modulates the frequency, rate or extent of stem cell differentiation. + GOC:obol + @@ -100211,8 +147762,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. negative regulation of stem cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. + GOC:obol + @@ -100238,8 +147796,15 @@ + Any process that activates or increases the frequency, rate or extent of stem cell differentiation. positive regulation of stem cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of stem cell differentiation. + GOC:obol + @@ -100264,8 +147829,15 @@ + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. regulation of mesenchymal cell proliferation involved in lung development + + + + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. + PMID:21513708 + @@ -100293,8 +147865,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. negative regulation of mesenchymal cell proliferation involved in lung development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. + PMID:21513708 + @@ -100322,8 +147901,15 @@ + Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. positive regulation of mesenchymal cell proliferation involved in lung development + + + + Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. + PMID:21513708 + @@ -100348,8 +147934,15 @@ + Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. regulation of epithelial cell proliferation involved in lung morphogenesis + + + + Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. + PMID:21513708 + @@ -100375,8 +147968,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. negative regulation of epithelial cell proliferation involved in lung morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. + PMID:21513708 + @@ -100402,8 +148002,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation. negative regulation of myoblast proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation. + GOC:obol + @@ -100428,8 +148035,15 @@ + Any process that modulates the frequency, rate or extent of heart morphogenesis. regulation of heart morphogenesis + + + + Any process that modulates the frequency, rate or extent of heart morphogenesis. + GOC:BHF + @@ -100456,8 +148070,15 @@ + Any process that modulates the frequency, rate or extent of steroid hormone secretion. regulation of steroid hormone secretion + + + + Any process that modulates the frequency, rate or extent of steroid hormone secretion. + GOC:sl + @@ -100485,8 +148106,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. negative regulation of steroid hormone secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. + GOC:sl + @@ -100514,8 +148142,15 @@ + Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. positive regulation of steroid hormone secretion + + + + Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. + GOC:sl + @@ -100540,8 +148175,15 @@ + Any process that modulates the frequency, rate or extent of androgen secretion. regulation of androgen secretion + + + + Any process that modulates the frequency, rate or extent of androgen secretion. + GOC:sl + @@ -100567,8 +148209,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion. negative regulation of androgen secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion. + GOC:sl + @@ -100594,8 +148243,50 @@ + Any process that activates or increases the frequency, rate or extent of androgen secretion. positive regulation of androgen secretion + + + + Any process that activates or increases the frequency, rate or extent of androgen secretion. + GOC:sl + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state. + mesenchymal cell differentiation involved in renal system development + + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state. + GOC:mtg_kidney_jan10 + GOC:obol + GOC:yaf + @@ -100620,8 +148311,15 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. regulation of skeletal muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. + GOC:obol + @@ -100647,8 +148345,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation. negative regulation of skeletal muscle cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation. + GOC:obol + @@ -100674,8 +148379,15 @@ + Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation. positive regulation of skeletal muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation. + GOC:obol + @@ -100701,8 +148413,15 @@ + Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. regulation of endothelial cell chemotaxis + + + + Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. + GOC:BHF + @@ -100729,8 +148448,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis. negative regulation of endothelial cell chemotaxis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis. + GOC:BHF + @@ -100757,8 +148483,15 @@ + Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. positive regulation of endothelial cell chemotaxis + + + + Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. + GOC:BHF + @@ -100783,8 +148516,16 @@ + Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. regulation of mesenchymal cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -100810,8 +148551,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process. negative regulation of mesenchymal cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -100837,8 +148586,16 @@ + Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process. positive regulation of mesenchymal cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -100863,8 +148620,15 @@ + Any process that modulates the frequency, rate or extent of RNA biosynthetic process. regulation of RNA biosynthetic process + + + + Any process that modulates the frequency, rate or extent of RNA biosynthetic process. + GOC:dph + @@ -100889,8 +148653,15 @@ + Any process that modulates the frequency, rate or extent of dendritic cell differentiation. regulation of dendritic cell differentiation + + + + Any process that modulates the frequency, rate or extent of dendritic cell differentiation. + GOC:obol + @@ -100916,8 +148687,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation. negative regulation of dendritic cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation. + GOC:obol + @@ -100943,8 +148721,15 @@ + Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation. positive regulation of dendritic cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation. + GOC:obol + @@ -100969,8 +148754,15 @@ + Any process that modulates the frequency, rate or extent of osteoclast development. regulation of osteoclast development + + + + Any process that modulates the frequency, rate or extent of osteoclast development. + GOC:obol + @@ -100996,8 +148788,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development. negative regulation of osteoclast development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development. + GOC:obol + @@ -101023,8 +148822,15 @@ + Any process that activates or increases the frequency, rate or extent of osteoclast development. positive regulation of osteoclast development + + + + Any process that activates or increases the frequency, rate or extent of osteoclast development. + GOC:obol + @@ -101049,8 +148855,15 @@ + Any process that modulates the frequency, rate or extent of vasculogenesis. regulation of vasculogenesis + + + + Any process that modulates the frequency, rate or extent of vasculogenesis. + GOC:obol + @@ -101076,8 +148889,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis. negative regulation of vasculogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis. + GOC:obol + @@ -101103,8 +148923,15 @@ + Any process that activates or increases the frequency, rate or extent of vasculogenesis. positive regulation of vasculogenesis + + + + Any process that activates or increases the frequency, rate or extent of vasculogenesis. + GOC:obol + @@ -101141,8 +148968,15 @@ + Any process that modulates the frequency, rate or extent of neuron migration. regulation of neuron migration + + + + Any process that modulates the frequency, rate or extent of neuron migration. + GOC:obol + @@ -101168,8 +149002,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration. negative regulation of neuron migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration. + GOC:obol + @@ -101195,8 +149036,15 @@ + Any process that activates or increases the frequency, rate or extent of neuron migration. positive regulation of neuron migration + + + + Any process that activates or increases the frequency, rate or extent of neuron migration. + GOC:obol + @@ -101222,8 +149070,15 @@ + Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. regulation of apoptotic signaling pathway + + + + Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. + GOC:mtg_apoptosis + @@ -101250,8 +149105,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. negative regulation of apoptotic signaling pathway + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. + GOC:mtg_apoptosis + @@ -101284,8 +149146,15 @@ + Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. positive regulation of apoptotic signaling pathway + + + + Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. + GOC:mtg_apoptosis + @@ -101311,8 +149180,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. negative regulation of chromosome organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. + GOC:obol + @@ -101338,8 +149214,15 @@ + Any process that activates or increases the frequency, rate or extent of chromosome organization. positive regulation of chromosome organization + + + + Any process that activates or increases the frequency, rate or extent of chromosome organization. + GOC:obol + @@ -101352,6 +149235,9 @@ + GC_ID:1 + PMID:30365038 + PMID:32761142 root @@ -101361,6 +149247,7 @@ + GC_ID:1 Teleostomi @@ -101370,6 +149257,7 @@ + GC_ID:1 Euteleostomi @@ -101379,6 +149267,7 @@ + GC_ID:1 Ecdysozoa @@ -101388,6 +149277,7 @@ + GC_ID:1 Zygnemophyceae @@ -101397,6 +149287,7 @@ + GC_ID:1 Streptophytina @@ -101406,6 +149297,7 @@ + GC_ID:1 cellular organisms @@ -101415,6 +149307,9 @@ + GC_ID:1 + PMID:22839753 + PMID:25450099 Archelosauria @@ -101424,6 +149319,7 @@ + GC_ID:1 Dipnotetrapodomorpha @@ -101433,15 +149329,31 @@ + GC_ID:1 + PMID:11062127 + PMID:9342353 Eumycetozoa + + + + + GC_ID:1 + PMID:11743200 + PMID:11791233 + Boreoeutheria + + + + + GC_ID:1 Acrogymnospermae @@ -101451,6 +149363,7 @@ + GC_ID:1 Gnetidae @@ -101460,6 +149373,7 @@ + GC_ID:1 Saccharomycotina @@ -101469,6 +149383,7 @@ + GC_ID:1 Schizosaccharomycetes @@ -101478,6 +149393,7 @@ + GC_ID:1 Actinopteri @@ -101487,6 +149403,9 @@ + GC_ID:1 + PMID:10874751 + PMID:11557979 Pancrustacea @@ -101496,6 +149415,9 @@ + GC_ID:1 + PMID:11557979 + PMID:9727836 Mandibulata @@ -101505,6 +149427,34 @@ + GC_ID:11 + PMID:10425795 + PMID:10425796 + PMID:10425797 + PMID:10490293 + PMID:10843050 + PMID:10939651 + PMID:10939673 + PMID:10939677 + PMID:11211268 + PMID:11321083 + PMID:11321113 + PMID:11411719 + PMID:11540071 + PMID:11542017 + PMID:11542087 + PMID:11760965 + PMID:12054223 + PMID:2112744 + PMID:270744 + PMID:32628106 + PMID:36748408 + PMID:7520741 + PMID:8123559 + PMID:8186100 + PMID:8590690 + PMID:9103655 + PMID:9336922 Bacteria @@ -101514,6 +149464,8 @@ + GC_ID:1 + PMID:29367151 Dictyosteliaceae @@ -101523,15 +149475,55 @@ + GC_ID:1 + PMID:29367151 Dictyosteliales + + + + + GC_ID:1 + Homininae + + + + + GC_ID:11 + PMID:10425795 + PMID:10425796 + PMID:10425797 + PMID:10490293 + PMID:10843050 + PMID:10939651 + PMID:10939673 + PMID:10939677 + PMID:11211268 + PMID:11321083 + PMID:11321113 + PMID:11411719 + PMID:11540071 + PMID:11541975 + PMID:11542064 + PMID:11542149 + PMID:11760965 + PMID:12054223 + PMID:2112744 + PMID:25527841 + PMID:270744 + PMID:32628106 + PMID:36748408 + PMID:8123559 + PMID:8590690 + PMID:9103655 + PMID:9336922 Archaea @@ -101541,6 +149533,7 @@ + GC_ID:1 Evosea @@ -101550,6 +149543,7 @@ + GC_ID:1 Discoba @@ -101559,6 +149553,7 @@ + GC_ID:1 Zygnematophycidae @@ -101568,6 +149563,7 @@ + GC_ID:1 Sar @@ -101577,15 +149573,53 @@ + GC_ID:1 + PMID:23020233 + PMID:30257078 Eukaryota + + + + + GC_ID:1 + PMID:11214319 + PMID:12082125 + PMID:12878460 + PMID:15522813 + Euarchontoglires + + + + + + + + + GC_ID:1 + Simiiformes + + + + + + + + + GC_ID:1 + Hominoidea + + + + + GC_ID:1 Zygnematales @@ -101595,6 +149629,7 @@ + GC_ID:1 Embryophyta @@ -101604,6 +149639,7 @@ + GC_ID:1 Teleostei @@ -101613,6 +149649,7 @@ + GC_ID:1 Tetrapoda @@ -101622,6 +149659,7 @@ + GC_ID:1 Amniota @@ -101631,6 +149669,7 @@ + GC_ID:1 Theria <mammals> @@ -101640,6 +149679,7 @@ + GC_ID:1 Sauria @@ -101649,6 +149689,10 @@ + GC_ID:1 + PMID:11062127 + PMID:29367151 + PMID:9342353 Dictyostelia @@ -101658,6 +149702,9 @@ + GC_ID:1 + PMID:16248873 + PMID:30257078 Viridiplantae @@ -101667,6 +149714,7 @@ + GC_ID:1 Coniferophyta @@ -101676,6 +149724,7 @@ + GC_ID:1 Opisthokonta @@ -101685,6 +149734,7 @@ + GC_ID:1 Metazoa @@ -101694,6 +149744,7 @@ + GC_ID:1 Bilateria @@ -101703,6 +149754,7 @@ + GC_ID:1 Protostomia @@ -101712,6 +149764,7 @@ + GC_ID:1 Deuterostomia @@ -101721,6 +149774,7 @@ + GC_ID:1 Alveolata @@ -101730,6 +149784,7 @@ + GC_ID:1 Euglenozoa @@ -101739,6 +149794,7 @@ + GC_ID:1 Gnetopsida @@ -101748,6 +149804,7 @@ + GC_ID:1 Gnetales @@ -101757,6 +149814,8 @@ + GC_ID:1 + PMID:25249442 Magnoliopsida @@ -101766,6 +149825,7 @@ + GC_ID:1 Schizosaccharomycetales @@ -101775,15 +149835,27 @@ + GC_ID:1 Streptophyta + + + + + GC_ID:1 + Haplorrhini + + + + + GC_ID:1 Glaucocystophyceae @@ -101793,6 +149865,7 @@ + GC_ID:1 Mammalia @@ -101802,6 +149875,7 @@ + GC_ID:1 Neopterygii @@ -101811,6 +149885,7 @@ + GC_ID:1 Dinosauria @@ -101820,6 +149895,7 @@ + GC_ID:1 Saurischia @@ -101829,6 +149905,7 @@ + GC_ID:1 Theropoda @@ -101838,6 +149915,7 @@ + GC_ID:1 Coelurosauria @@ -101847,6 +149925,12 @@ + GC_ID:1 + PMID:15689432 + PMID:16151185 + PMID:17010206 + PMID:17051209 + PMID:17572334 Dikarya @@ -101856,6 +149940,7 @@ + GC_ID:1 Taphrinomycotina @@ -101865,6 +149950,9 @@ + GC_ID:1 + PMID:11062127 + PMID:12684019 Fungi @@ -101874,6 +149962,8 @@ + GC_ID:1 + PMID:17572334 Ascomycota @@ -101883,6 +149973,7 @@ + GC_ID:1 Saccharomycetes @@ -101892,6 +149983,7 @@ + GC_ID:1 Saccharomycetales @@ -101901,6 +149993,7 @@ + GC_ID:1 Saccharomycetaceae @@ -101910,6 +150003,7 @@ + GC_ID:1 Schizosaccharomycetaceae @@ -101919,6 +150013,7 @@ + GC_ID:1 Schizosaccharomyces @@ -101928,6 +150023,7 @@ + GC_ID:1 Schizosaccharomyces pombe @@ -101937,6 +150033,7 @@ + GC_ID:1 Saccharomyces @@ -101946,6 +150043,7 @@ + GC_ID:1 Saccharomyces cerevisiae @@ -101955,6 +150053,7 @@ + GC_ID:1 Insecta @@ -101964,6 +150063,9 @@ + GC_ID:1 + PMID:23020233 + PMID:30257078 Amoebozoa @@ -101973,6 +150075,8 @@ + GC_ID:1 + PMID:29367151 Dictyostelium @@ -101982,6 +150086,7 @@ + GC_ID:1 Tracheophyta @@ -101991,6 +150096,7 @@ + GC_ID:1 Spermatophyta @@ -102000,6 +150106,7 @@ + GC_ID:1 Eumetazoa @@ -102009,6 +150116,7 @@ + GC_ID:1 Arthropoda @@ -102018,6 +150126,7 @@ + GC_ID:1 Hexapoda @@ -102027,6 +150136,7 @@ + GC_ID:1 saccharomyceta @@ -102036,6 +150146,7 @@ + GC_ID:1 Chordata @@ -102045,6 +150156,7 @@ + GC_ID:1 Vertebrata <vertebrates> @@ -102054,6 +150166,7 @@ + GC_ID:1 Gnathostomata <vertebrates> @@ -102063,6 +150176,7 @@ + GC_ID:1 Euphyllophyta @@ -102072,6 +150186,7 @@ + GC_ID:1 Actinopterygii @@ -102081,6 +150196,7 @@ + GC_ID:1 Sarcopterygii @@ -102090,6 +150206,7 @@ + GC_ID:1 Sauropsida @@ -102099,6 +150216,7 @@ + GC_ID:1 Archosauria @@ -102108,6 +150226,7 @@ + GC_ID:1 Aves @@ -102117,6 +150236,7 @@ + GC_ID:1 Panarthropoda @@ -102126,11 +150246,72 @@ + GC_ID:1 Craniata <chordates> + + + + + GC_ID:1 + Eutheria + + + + + + + + + GC_ID:1 + Primates + + + + + + + + + GC_ID:1 + Catarrhini + + + + + + + + + GC_ID:1 + Hominidae + + + + + + + + + GC_ID:1 + Homo + + + + + + + + + GC_ID:1 + Homo sapiens + + + + @@ -102155,6 +150336,12 @@ + + + + + + @@ -102167,6 +150354,12 @@ + + + + + + @@ -102221,6 +150414,12 @@ + + + + + + @@ -102233,6 +150432,12 @@ + + + + + + @@ -102263,6 +150468,12 @@ + + + + + + @@ -102323,6 +150534,12 @@ + + + + + + @@ -102755,6 +150972,12 @@ + + + + + + @@ -102779,11 +151002,112 @@ + + + + + A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids. + region + + + + + A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids. + SO:ke + + + + + + + + Any extent of continuous biological sequence. + sequence_feature + + + + + Any extent of continuous biological sequence. + LAMHDI:mb + SO:ke + + + + + + + + + + + + + + + A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions. + http://en.wikipedia.org/wiki/Gene + This term is mapped to MGED. Do not obsolete without consulting MGED ontology. A gene may be considered as a unit of inheritance. + gene + + + + + A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions. + SO:immuno_workshop + + + + + http://en.wikipedia.org/wiki/Gene + wiki + + + + + A collection of discontinuous sequences. sequence_collection + + + + A collection of discontinuous sequences. + SO:ke + + + + + + + + + A region defined by its disposition to be involved in a biological process. + biological_region + + + + + A region defined by its disposition to be involved in a biological process. + SO:cb + + + + + + + + + A collection of related genes. + gene_group + + + + + A collection of related genes. + SO:ma + @@ -102791,11 +151115,16 @@ - - - + An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity. + BFO:0000003 processual entity + + + + An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity. + span:ProcessualEntity + @@ -102837,6 +151166,71 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The clusters of hormone-producing cells that are scattered throughout the pancreas. + AAO:0010406 + BTO:0000991 + CALOHA:TS-0741 + EFO:0000856 + EMAPA:32927 + EV:0100130 + FMA:16016 + GAID:324 + MA:0000127 + MAT:0000076 + MESH:D007515 + MIAA:0000076 + NCIT:C12608 + VHOG:0000646 + Wikipedia:Islets_of_Langerhans + XAO:0000159 + islet of Langerhans + + + + + The clusters of hormone-producing cells that are scattered throughout the pancreas. + MA:0000127 + MESH:A03.734.414 + MP:0005215 + + + + @@ -102859,8 +151253,21 @@ + A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]. + BTO:0002107 + FMA:85391 + FMA:85392 + NCIT:C13167 + SCTID:68439008 + Wikipedia:Submucosa submucosa + + + + A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]. + Wikipedia:Submucosa + @@ -102874,9 +151281,40 @@ - + A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. + AAO:0000429 + BAMS:PNS + BILA:0000081 + BIRNLEX:1111 + BTO:0001028 + CALOHA:TS-0808 + EFO:0000891 + EHDAA2:0001445 + EHDAA:2893 + EMAPA:16665 + EV:0100335 + FMA:9903 + GAID:715 + MA:0000218 + MAT:0000338 + MESH:D017933 + MIAA:0000338 + NCIT:C12465 + SCTID:362292005 + TAO:0000142 + VHOG:0000399 + Wikipedia:Peripheral_nervous_system + XAO:0000178 + ZFA:0000142 + neuronames:3232 peripheral nervous system + + + + A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. + GO:0007422 + @@ -102896,8 +151334,34 @@ + The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]. + AAO:0010487 + BIRNLEX:2516 + BTO:0001832 + CALOHA:TS-2050 + EFO:0000893 + EHDAA2:0001971 + EHDAA:3769 + EMAPA:16985 + FMA:9906 + GAID:710 + MA:0000225 + MESH:D013564 + MIAA:0000100 + NCIT:C12795 + SCTID:362484004 + TAO:0001576 + VHOG:0000384 + Wikipedia:Sympathetic_nervous_system + ZFA:0001576 sympathetic nervous system + + + + The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]. + GO:0048485 + @@ -102924,8 +151388,27 @@ + Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. + EHDAA:6530 + EV:0100152 + FMA:86166 + GAID:933 + MA:0000151 + MAT:0000284 + MESH:D012867 + MIAA:0000284 + SCTID:20795001 + VHOG:0000860 + Wikipedia:Skin zone of skin + + + + Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. + Wikipedia:Skin + http://orcid.org/0000-0002-6601-2165 + @@ -102933,11 +151416,168 @@ - - - + A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. + AEO:0000192 + CARO:0000010 + FMA:50705 + Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. non-material anatomical boundary + + + + A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. + CARO:0000010 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin. + BTO:0000650 + CALOHA:TS-1302 + EFO:0002542 + EMAPA:35305 + EV:0100129 + FMA:16018 + MA:0001582 + NCIT:C32509 + SCTID:361339003 + TAO:0001260 + VHOG:0000049 + Wikipedia:Islets_of_Langerhans + ZFA:0001260 + endocrine pancreas + + + + + The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin. + GO:GO + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]. + AAO:0010407 + BTO:0000434 + CALOHA:TS-1241 + EMAPA:35328 + EV:0100093 + FMA:16017 + MA:0002415 + NCIT:C32546 + SCTID:248202004 + TAO:0001249 + VHOG:0000048 + Wikipedia:Exocrine_component_of_pancreas + XAO:0000137 + ZFA:0001249 + exocrine pancreas + + + + + The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]. + GOC:GO + http://orcid.org/0000-0002-6601-2165 + @@ -102968,8 +151608,20 @@ + A light sensing organ composed of ommatidia. + BTO:0001921 + HAO:0000217 + TGMA:0000024 + Wikipedia:Compound_eye compound eye + + + + A light sensing organ composed of ommatidia. + FB:gg + Wikipedia:Compound_eye + @@ -103016,8 +151668,30 @@ + An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid. + AAO:0010340 + BIRNLEX:1169 + BTO:0004688 + EHDAA2:0000484 + EHDAA:936 + EMAPA:16198 + FMA:54448 + MA:0000261 + NCIT:C12401 + SCTID:181143004 + TAO:0000107 + VHOG:0000275 + XAO:0000179 + ZFA:0000107 camera-type eye + + + + An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid. + GO:0043010 + https://orcid.org/0000-0002-6601-2165 + @@ -103048,8 +151722,31 @@ + An organ that is capable of transducing sensory stimulus to the nervous system. + AEO:0000094 + BSA:0000121 + BTO:0000202 + CALOHA:TS-2043 + EHDAA2:0001824 + EHDAA:500 + EMAPA:35955 + GAID:63 + HAO:0000930 + MA:0000017 + MESH:D012679 + NCIT:C33224 + SCTID:244485009 + VHOG:0001407 + WBbt:0006929 sense organ + + + + An organ that is capable of transducing sensory stimulus to the nervous system. + https://github.com/obophenotype/uberon/issues/549 + https://orcid.org/0000-0002-6601-2165 + @@ -103080,8 +151777,16 @@ + Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. + galen:Tube tube + + + + Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. + http://orcid.org/0000-0002-6601-2165 + @@ -103095,8 +151800,30 @@ + Major subdivision of an organism that protrudes from the body[DOS, CARO]. + AEO:0000193 + BILA:0000018 + BTO:0001492 + CARO:0010003 + EFO:0000799 + EHDAA2:0003193 + EV:0100155 + HAO:0000144 + MAT:0000023 + MESH:D005121 + MIAA:0000023 + NCIT:C61460 + VSAO:0000075 + Wikipedia:Appendage + XAO:0000218 appendage + + + + Major subdivision of an organism that protrudes from the body[DOS, CARO]. + CARO:DOS + @@ -103122,8 +151849,20 @@ + A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions. + BTO:0002330 + FMA:62517 + NCIT:C32918 + SCTID:298225002 + Wikipedia:Lamina_propria lamina propria + + + + A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions. + Wikipedia:Lamina_propria + @@ -103148,8 +151887,19 @@ + A lamina propria that is part of a respiratory airway. + EMAPA:35877 + FMA:265157 + MA:0001858 + NCIT:C49305 lamina propria of trachea + + + + A lamina propria that is part of a respiratory airway. + OBOL:automatic + @@ -103169,8 +151919,43 @@ + The head is the anterior-most division of the body [GO]. + AAO:0010335 + AEO:0000106 + BILA:0000115 + BIRNLEX:1230 + BTO:0000282 + CALOHA:TS-0436 + EFO:0000964 + EHDAA2:0003106 + EMAPA:31858 + FMA:7154 + GAID:61 + HAO:0000397 + MA:0000023 + MAT:0000294 + MESH:D006257 + MIAA:0000294 + NCIT:C12419 + SCTID:302548004 + SPD:0000016 + TAO:0001114 + TGMA:0000002 + VHOG:0001644 + WBbt:0005739 + Wikipedia:Head + XAO:0003024 + ZFA:0001114 + galen:Head head + + + + The head is the anterior-most division of the body [GO]. + GO:0060322 + Wikipedia:Head + @@ -103197,8 +151982,24 @@ + Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. + FMA:9581 + GAID:19 + MESH:D012704 + NCIT:C13169 + SCTID:362878009 + TAO:0005425 + Wikipedia:Serous_membrane + ZFA:0005425 serous membrane + + + + Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. + Wikipedia:Serous_membrane + https://github.com/obophenotype/uberon/issues/86 + @@ -103236,8 +152037,36 @@ + Dense regular connective tissue that connects muscle to bone[VSAO]. + AEO:0000091 + BTO:0001356 + CALOHA:TS-1021 + EHDAA2:0003091 + EMAPA:35854 + EV:0100149 + FMA:9721 + GAID:276 + MA:0000115 + MESH:D013710 + NCIT:C13045 + SCTID:256667004 + VHOG:0001286 + VSAO:0000073 + Wikipedia:Tendon + XAO:0000173 + ZFA:0005647 + galen:Tendon tendon + + + + Dense regular connective tissue that connects muscle to bone[VSAO]. + GO_REF:0000034 + VSAO:0000073 + Wikipedia:Tendon + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -103263,9 +152092,45 @@ - + A biological tissue mass, most commonly a mass of nerve cell bodies. + AAO:0010426 + AEO:0000135 + BAMS:G + BTO:0000497 + CALOHA:TS-0397 + EFO:0000899 + EHDAA2:0003135 + EHDAA:2897 + EHDAA:4662 + EHDAA:5621 + EHDAA:918 + EMAPA:32846 + EV:0100372 + FMA:5884 + MA:0002406 + MAT:0000207 + MAT:0000343 + MESH:D005724 + MIAA:0000207 + MIAA:0000343 + NCIT:C12719 + NLXANAT:100302 + TAO:0000190 + TGMA:0001016 + VHOG:0000156 + WBbt:0005189 + Wikipedia:Ganglion + XAO:0000209 + ZFA:0000190 ganglion + + + + A biological tissue mass, most commonly a mass of nerve cell bodies. + Wikipedia:Ganglion + https://github.com/obophenotype/uberon/issues/300 + @@ -103273,8 +152138,17 @@ + An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity. + TGMA:0000729 + Wikipedia:Eye#Simple_eyes simple eye + + + + An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity. + Wikipedia:Eye#Simple_eyes + @@ -103288,9 +152162,15 @@ - + A tubular structure that contains, conveys body fluid, such as blood or lymph. vessel + + + + A tubular structure that contains, conveys body fluid, such as blood or lymph. + https://orcid.org/0000-0002-6601-2165 + @@ -103316,8 +152196,84 @@ + A tubular structure that transports secreted or excreted substances. + AAO:0011123 + FMA:30320 + NCIT:C12948 + SCTID:91726008 + TAO:0005171 + Wikipedia:Duct_(anatomy) + XAO:0004000 + ZFA:0005171 + galen:Duct duct + + + + A tubular structure that transports secreted or excreted substances. + http://orcid.org/0000-0002-6601-2165 + http://www.siumed.edu/~dking2/intro/glands.htm#ducts + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]. + AAO:0010396 + BTO:0000706 + CALOHA:TS-1306 + EFO:0000840 + EMAPA:19252 + EV:0100077 + FMA:7201 + GAID:306 + MA:0000333 + MESH:D007420 + MIAA:0000046 + NCIT:C12379 + SCTID:181254001 + VHOG:0000054 + Wikipedia:Large_intestine_(anatomy) + XAO:0000131 + galen:LargeIntestine + large intestine + + + + + A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]. + ISBN:0073040584 + Wikipedia:Large_intestine_(anatomy) + @@ -103337,8 +152293,17 @@ + Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers. + FMA:82482 + galen:Wall anatomical wall + + + + Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers. + FMA:82482 + @@ -103352,11 +152317,34 @@ - - - + Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. + AAO:0010825 + AEO:0000003 + BILA:0000003 + CARO:0000003 + EHDAA2:0003003 + EMAPA:0 + FMA:305751 + FMA:67135 + GAID:781 + HAO:0000003 + MA:0003000 + MESH:D000825 + SCTID:362889002 + TAO:0000037 + TGMA:0001823 + VHOG:0001759 + XAO:0003000 + ZFA:0000037 + http://dbpedia.org/ontology/AnatomicalStructure anatomical structure + + + + Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. + CARO:0000003 + @@ -103383,11 +152371,26 @@ - - - + Anatomical structure that performs a specific function or group of functions [WP]. + BIRNLEX:4 + CARO:0020004 + EFO:0000634 + EMAPA:35949 + ENVO:01000162 + FMA:67498 + MA:0003001 + NCIT:C13018 + SCTID:272625005 + WBbt:0003760 + Wikipedia:Organ_(anatomy) organ + + + + Anatomical structure that performs a specific function or group of functions [WP]. + Wikipedia:Organ_(anatomy) + @@ -103395,8 +152398,16 @@ + A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. + FMA:86140 organ subunit + + + + A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. + http://orcid.org/0000-0002-6601-2165 + @@ -103410,11 +152421,21 @@ - - - + A multicellular structure that is a part of an organ. + AAO:0011124 + BIRNLEX:16 + EFO:0000635 + FMA:82472 + SCTID:113343008 + SCTID:91717005 organ part + + + + A multicellular structure that is a part of an organ. + http://orcid.org/0000-0002-6601-2165 + @@ -103435,9 +152456,22 @@ - + Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts. + EHDAA2:0001606 + EHDAA:1568 + EHDAA:2219 + EMAPA:16737 + FMA:265130 + SCTID:361110005 + VHOG:0000393 respiratory tract + + + + Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts. + https://orcid.org/0000-0002-6601-2165 + @@ -103464,8 +152498,21 @@ + The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. + BTO:0001043 + BilaDO:0000004 + EFO:0001272 + FBdv:00005369 + WBls:0000041 + XtroDO:0000084 fully formed stage + + + + The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. + https://orcid.org/0000-0002-6601-2165 + @@ -103493,8 +152540,28 @@ + A life cycle stage that starts with fertilization and ends with the fully formed embryo. + BilaDO:0000002 + EV:0300001 + FBdv:00005289 + FMA:72652 + HsapDv:0000002 + MmusDv:0000002 + OGES:000000 + OGES:000022 + SCTID:296280003 + WBls:0000003 + WBls:0000092 + WBls:0000102 + XAO:1000012 embryo stage + + + + A life cycle stage that starts with fertilization and ends with the fully formed embryo. + http://orcid.org/0000-0002-6601-2165 + @@ -103509,11 +152576,17 @@ - - - + End of the life of an organism. + XAO:0000437 + XtroDO:0000085 death stage + + + + End of the life of an organism. + XAO:0000437 + @@ -103539,8 +152612,17 @@ + An section of a respiratory tract. + FMA:45660 + MA:0000434 proximo-distal subdivision of respiratory tract + + + + An section of a respiratory tract. + http://orcid.org/0000-0002-6601-2165 + @@ -103565,8 +152647,18 @@ + Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. + BIRNLEX:1157 + NCIT:C13040 + SCTID:25087005 regional part of nervous system + + + + Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. + BIRNLEX:1157 + @@ -103592,8 +152684,20 @@ + Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. + FMA:85544 + NCIT:C34076 + SCTID:118966000 + galen:ComplexSkeletalStructure subdivision of skeletal system + + + + Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + @@ -103608,8 +152712,27 @@ + The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. + EHDAA2:0001968 + EHDAA:1494 + EHDAA:350 + EHDAA:4784 + EHDAA:4790 + EHDAA:4796 + EHDAA:7860 + EMAPA:16096 + FMA:87656 + NCIT:C34309 + Wikipedia:External_ectoderm external ectoderm + + + + The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. + MGI:anna + MP:0012532 + @@ -103633,8 +152756,15 @@ + An anatomical structure that develops from the endoderm and the mesoderm. mixed endoderm/mesoderm-derived structure + + + + An anatomical structure that develops from the endoderm and the mesoderm. + https://orcid.org/0000-0002-6601-2165 + @@ -103662,8 +152792,15 @@ + An anatomical structure that develops from the ectoderm, mesoderm and endoderm. mixed ectoderm/mesoderm/endoderm-derived structure + + + + An anatomical structure that develops from the ectoderm, mesoderm and endoderm. + https://orcid.org/0000-0002-6601-2165 + @@ -103701,8 +152838,23 @@ + A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum. + BTO:0001508 + EHDAA2:0000005 + FMA:292334 + GAID:1295 + MESH:D009028 + NCIT:C34212 + SCTID:361474003 + Wikipedia:Morula morula + + + + A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum. + MP:0012130 + @@ -103728,9 +152880,28 @@ - + A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes. + BTO:0003135 + EHDAA2:0002220 + EHDAA:31 + EHDAA:62 + EMAPA:16035 + FMA:18674 + GAID:410 + MA:0001715 + MESH:D015044 + NCIT:C33896 + TAO:0001111 + Wikipedia:Zona_pellucida + ZFA:0001111 zona pellucida + + + + A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes. + Wikipedia:Zona_pellucida + @@ -103750,8 +152921,25 @@ + A mass of cells that develop into the body of the embryo and some extraembryonic tissues. + EFO:0000547 + EHDAA2:0000830 + EHDAA:40 + EMAPA:16041 + FMA:86557 + NCIT:C13740 + SCTID:361456007 + VHOG:0000742 + Wikipedia:Inner_cell_mass inner cell mass + + + + A mass of cells that develop into the body of the embryo and some extraembryonic tissues. + ISBN:0-683-40008-8 + MGI:pvb + @@ -103777,8 +152965,26 @@ + The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta. + BTO:0001079 + CALOHA:TS-1070 + EV:0100120 + FMA:83029 + GAID:1152 + MESH:D014327 + NCIT:C93292 + SCTID:362839005 + Wikipedia:Trophoblast + Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast] trophoblast + + + + The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta. + ISBN:0-683-40008-8 + MP:0005031 + @@ -103792,8 +152998,18 @@ + A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc. + FMA:293863 + NCIT:C34112 + Wikipedia:Bilaminar_disc bilaminar disc + + + + A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc. + MP:0003886 + @@ -103814,8 +153030,22 @@ + Stage succeeding embryo, including mature structure. + BilaDO:0000003 + OGES:000010 + OGES:000014 + OGES:000024 + WBls:0000022 + WBls:0000093 + WBls:0000103 post-embryonic stage + + + + Stage succeeding embryo, including mature structure. + https://orcid.org/0000-0002-6601-2165 + @@ -103829,8 +153059,16 @@ + Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]. + FMA:7145 membrane organ + + + + Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]. + FMA:7145 + @@ -103851,8 +153089,19 @@ + Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]. + TAO:0002173 + Wikipedia:Cardiac_neural_crest + XAO:0004190 + ZFA:0001648 cardiac neural crest + + + + Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]. + Wikipedia:Cardiac_neural_crest + @@ -103873,8 +153122,21 @@ + A lung lobe is one of the rounded projections that compose the lung[GO]. + EMAPA:36281 + FMA:7311 + MA:0003098 + NCIT:C34021 + SCTID:245524004 + galen:LobeOfLung lobe of lung + + + + A lung lobe is one of the rounded projections that compose the lung[GO]. + GOC:GO + @@ -103900,8 +153162,16 @@ + The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]. + FMA:73750 lung vasculature + + + + The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]. + GOC:GO + @@ -103922,11 +153192,20 @@ - - - + An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism. + FBdv:00000000 + HsapDv:0000001 + MmusDv:0000001 + OGES:000011 + ncithesaurus:Life life cycle + + + + An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism. + https://orcid.org/0000-0002-6601-2165 + @@ -103940,11 +153219,29 @@ - - - + A spatiotemporal region encompassing some part of the life cycle of an organism. + BILS:0000105 + EFO:0000399 + FBdv:00007012 + FMA:24120 + HsapDv:0000000 + MESH:D008018 + MmusDv:0000000 + OlatDv:0000010 + PdumDv:0000090 + WBls:0000002 + XAO:1000000 + ZFS:0000000 + ZFS:0100000 + ncithesaurus:Developmental_Stage life cycle stage + + + + A spatiotemporal region encompassing some part of the life cycle of an organism. + https://orcid.org/0000-0002-6601-2165 + @@ -103965,8 +153262,26 @@ + A stage at which the organism is a single cell produced by means of sexual reproduction. + BILS:0000106 + BilaDO:0000005 + EFO:0001322 + EHDAA:27 + FBdv:00005288 + NCIT:C12601 + PdumDv:0000100 + VHOG:0000745 + Wikipedia:Zygote + XAO:1000001 + ZFS:0000001 zygote stage + + + + A stage at which the organism is a single cell produced by means of sexual reproduction. + Wikipedia:Zygote + @@ -104004,8 +153319,28 @@ + The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. + BILS:0000107 + BilaDO:0000006 + EFO:0001290 + FBdv:00000054 + MESH:D002970 + MmusDv:0000004 + OGES:000015 + OGES:000020 + PdumDv:0000200 + Wikipedia:Cleavage_(embryo) + XAO:1000004 + ZFS:0000046 cleavage stage + + + + The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. + GO:0040016 + Wikipedia:Cleavage_(embryo) + @@ -104026,8 +153361,27 @@ + An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + BILS:0000108 + BilaDO:0000007 + EFO:0001282 + HsapDv:0000006 + MmusDv:0000007 + OGES:000003 + OGES:000016 + OGES:000021 + WBls:0000005 + Wikipedia:Blastula + XAO:1000003 + ZFS:0000045 blastula stage + + + + An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + Wikipedia:Blastula + @@ -104060,8 +153414,26 @@ + A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + BILS:0000109 + BilaDO:0000008 + EFO:0001296 + FBdv:00005317 + HsapDv:0000010 + MmusDv:0000013 + OGES:000004 + OGES:000019 + WBls:0000010 + XAO:1000005 + ZFS:0000047 gastrula stage + + + + A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + GO:0007369 + @@ -104094,8 +153466,20 @@ + Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + BILS:0000110 + BilaDO:0000009 + HsapDv:0000012 + MmusDv:0000017 + XAO:1000006 neurula stage + + + + Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + GO:0001841 + @@ -104122,8 +153506,22 @@ + A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. + BILS:0000111 + BilaDO:0000010 + HsapDv:0000015 + MmusDv:0000018 + OGES:000005 + OGES:000032 + Wikipedia:Organogenesis organogenesis stage + + + + A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. + Wikipedia:Organogenesis + @@ -104162,9 +153560,22 @@ - + The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin. + EMAPA:35521 + FMA:27533 + MA:0001782 + SCTID:201609008 lung connective tissue + + + + The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin. + ISBN:0-683-40008-8 + MGI:anna + MP:0002276 + PMID:14635660 + @@ -104201,8 +153612,18 @@ + The epithelial layer of the lung. + BTO:0001653 + EMAPA:32860 + MA:0001783 lung epithelium + + + + The epithelial layer of the lung. + MP:0006382 + @@ -104234,8 +153655,17 @@ + A tube in the respiratory system. Examples: bronchus, bronchiole, trachea. + FMA:12224 respiratory tube + + + + A tube in the respiratory system. Examples: bronchus, bronchiole, trachea. + GO:0030323 + http://orcid.org/0000-0002-6601-2165 + @@ -104262,8 +153692,22 @@ + Structure derived from foregut that becomes a lung[GO]. + BTO:0001643 + EHDAA2:0004089 + NCIT:C34260 + NCIT:C34282 + SCTID:361427007 + Wikipedia:Respiratory_bud lung bud + + + + Structure derived from foregut that becomes a lung[GO]. + GO:0060431 + Wikipedia:Respiratory_bud + @@ -104283,8 +153727,19 @@ + A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. + CARO:0001001 + NLX:147821 neuron projection bundle + + + + A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. + CARO:0001001 + FBC:DOS + FBbt:00005099 + @@ -104304,8 +153759,20 @@ + A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO). + AEO:0000136 + FMA:83686 + NCIT:C13197 + NLX:28443 + Wikipedia:Nucleus_(neuroanatomy) neural nucleus + + + + A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO). + NLX:28443 + @@ -104330,8 +153797,19 @@ + Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves. + FMA:54501 + NLX:28532 + SCTID:280160003 + Wikipedia:Cranial_nerve_nucleus cranial nerve nucleus + + + + Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves. + NLX:28532 + @@ -104381,17 +153859,234 @@ + FMA:30322 + FMA:82500 + MESH:D008566 + NCIT:C12749 membranous layer + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus. + BTO:0001978 + CALOHA:TS-2160 + EMAPA:18256 + FMA:15703 + MA:0000330 + NCIT:C12375 + SCTID:245438008 + Wikipedia:Anal_canal + galen:AnalCanal + anal canal + + + + + The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus. + Wikipedia:Anal_canal + + + + + + + + + + + + + + + + + + + + + Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine. + AAO:0000246 + ANISEED:1235303 + BSA:0000093 + BTO:0000648 + CALOHA:TS-0490 + EFO:0000834 + EMAPA:32874 + EV:0100071 + FMA:7199 + GAID:295 + MA:0000328 + MA:0001524 + MESH:D007422 + MIAA:0000043 + NCIT:C12736 + SCTID:256876008 + TAO:0001338 + VHOG:0000056 + WBbt:0005772 + Wikipedia:Intestine + XAO:0000129 + ZFA:0001338 + galen:Intestine + intestine + + + + + Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine. + GOC:GO + Wikipedia:Intestine + + + + + Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]. + FMA:3724 + SCTID:91837002 orifice + + + + Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]. + FMA:3724 + + + + + + + + + + + + + + + + + + + + + + + + + + + Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures. + AAO:0000095 + GAID:1206 + MESH:D002988 + NCIT:C34127 + SCTID:362857006 + SCTID:370631000 + VHOG:0001186 + Wikipedia:Cloaca + XAO:0000244 + ZFA:0005781 + cloaca + + + + + Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures. + ISBN:0073040584 + Wikipedia:Cloaca + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]. + EHDAA2:0000256 + EHDAA:4895 + EMAPA:27573 + Wikipedia:Cloaca_(embryology) + embryonic cloaca + + + + + Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]. + MP:0010115 + Wikipedia:Cloaca_(embryology) + @@ -104428,8 +154123,44 @@ + The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). + AAO:0010355 + BTO:0001090 + BTO:0004698 + CALOHA:TS-1315 + EFO:0000825 + EHDAA2:0001326 + EHDAA:542 + EMAPA:16262 + FMA:49184 + GAID:75 + MA:0000341 + MA:0002474 + MAT:0000038 + MESH:D009055 + MIAA:0000038 + SCTID:21082005 + TADS:0000040 + TAO:0000547 + TAO:0000590 + TGMA:0000131 + VHOG:0000280 + VHOG:0000812 + Wikipedia:Mouth + XAO:0003029 + ZFA:0000547 + ZFA:0000590 + galen:Mouth + http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg mouth + + + + The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). + Wikipedia:Mouth + https://github.com/obophenotype/uberon/wiki/The-digestive-tract + @@ -104443,8 +154174,16 @@ + The orifice that connects the mouth to the exterior of the body. + FMA:59806 oral opening + + + + The orifice that connects the mouth to the exterior of the body. + https://github.com/obophenotype/uberon/wiki/The-digestive-tract + @@ -104481,8 +154220,77 @@ + Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present). + AAO:0000053 + AAO:0000960 + BSA:0000107 + CALOHA:TS-1315 + EFO:0001975 + EHDAA2:0001324 + EHDAA:6970 + EMAPA:17411 + EMAPA:18399 + EV:0100057 + FMA:20292 + HAO:0000669 + NCIT:C12421 + SCTID:181220002 + TAO:0001027 + TGMA:0000102 + VHOG:0000188 + WBbt:0005255 + XAO:0000126 + ZFA:0001027 oral cavity + + + + Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present). + ISBN:0073040584 + https://github.com/obophenotype/uberon/wiki/The-digestive-tract + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A section dividing a colon along a proximal-distal axis. + FMA:222905 + proximal-distal subdivision of colon + + + + + A section dividing a colon along a proximal-distal axis. + http://orcid.org/0000-0002-6601-2165 + @@ -104543,9 +154351,16 @@ - + The pair of anatomical structures comprised of a left lung and right lung. + FMA:68877 pair of lungs + + + + The pair of anatomical structures comprised of a left lung and right lung. + http://orcid.org/0000-0002-6601-2165 + @@ -104576,8 +154391,58 @@ + Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. + SCTID:272626006 + SPD:0000428 + TGMA:0001247 respiration organ + + + + Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. + GO:0007585 + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity. + AEO:0000184 + BTO:0000491 + EHDAA2_RETIRED:0003184 + ENVO:02000022 + FMA:9674 + galen:Excretion + excreta + + + + + A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity. + GO:0007588 + http://orcid.org/0000-0002-6601-2165 + @@ -104615,9 +154480,39 @@ - + A fluid that is composed of blood plasma and erythrocytes. + AAO:0000046 + BTO:0000089 + CALOHA:TS-0079 + EFO:0000296 + EHDAA2:0000176 + EHDAA:418 + EMAPA:16332 + ENVO:02000027 + EV:0100047 + FMA:9670 + GAID:965 + MA:0000059 + MESH:D001769 + MIAA:0000315 + NCIT:C12434 + TAO:0000007 + VHOG:0000224 + Wikipedia:Blood + XAO:0000124 + ZFA:0000007 + galen:Blood blood + + + + A fluid that is composed of blood plasma and erythrocytes. + FMA:9670 + Wikipedia:Blood + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/9 + @@ -104648,8 +154543,121 @@ + Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. + CARO:0000081 haemolymphatic fluid + + + + Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + The bone forming the forehead and roof of the eye orbit. + AAO:0000206 + EMAPA:19016 + FMA:52734 + GAID:226 + MA:0001466 + MESH:D005624 + NCIT:C32635 + SCTID:181793006 + VSAO:0000208 + Wikipedia:Frontal_bone + tetrapod frontal bone + + + + + The bone forming the forehead and roof of the eye orbit. + ISBN:0-683-40008-8 + MP:0000107 + PMID:7914451 + Wikipedia:Frontal_bone + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital. + FMA:24939 + NCIT:C32158 + SCTID:361831006 + Wikipedia:Atlanto-occipital_joint + ncithesaurus:Atlanto-occipital_Joint-Atlanto + atlanto-occipital joint + + + + + The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital. + Wikipedia:Atlanto-occipital_joint + @@ -104686,8 +154694,21 @@ + A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath. + BTO:0000051 + FMA:45087 + FMA:76715 + NCIT:C96299 + SCTID:361885006 + Wikipedia:Tendon_sheath tendon sheath + + + + A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath. + Wikipedia:Tendon_sheath + @@ -104718,8 +154739,101 @@ + Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + BILA:0000059 + BTO:0000128 + GAID:1294 + MESH:D036703 + OGEM:000006 + Wikipedia:Blastula blastula + + + + Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + Wikipedia:Blastula + + + + + + + + + + + + + + + + + + + + + + + + + + Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells. + BTO:0000271 + CALOHA:TS-0164 + EFO:0003038 + EMAPA:27375 + FMA:14984 + FMA:85388 + MA:0003194 + SCTID:362157008 + colonic mucosa + + + + + Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a duodenum [Automatically generated definition]. + BTO:0000367 + CALOHA:TS-0213 + EMAPA:27235 + FMA:14942 + MA:0003207 + SCTID:362146003 + duodenal mucosa + + + + + A mucosa that is part of a duodenum [Automatically generated definition]. + OBOL:automatic + @@ -104734,8 +154848,56 @@ + The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin. + BTO:0000503 + EMAPA:27181 + FMA:14919 gastric gland + + + + The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin. + MGI:anna + + + + + + + + + + + + + + + + + + + + + + + + + + Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach. + BTO:0000504 + CALOHA:TS-2235 + FMA:62973 + GAID:1166 + MESH:D010189 + pancreatic juice + + + + + Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach. + GO:0030157 + @@ -104760,8 +154922,17 @@ + The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity). + BTO:0000547 + FMA:45653 gut wall + + + + The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity). + http://orcid.org/0000-0002-6601-2165 + @@ -104792,8 +154963,55 @@ + Bone marrow in which the fat cells predominate in the meshes of the reticular network. + BTO:0000635 + FMA:74596 + SCTID:328639002 + SCTID:5023006 yellow bone marrow + + + + Bone marrow in which the fat cells predominate in the meshes of the reticular network. + http://medical-dictionary.thefreedictionary.com/Yellow+Marrow + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]. + BTO:0000640 + FMA:15052 + SCTID:266297002 + intestinal gland + + + + + A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]. + https://orcid.org/0000-0002-6601-2165 + @@ -104819,8 +155037,28 @@ + A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]. + AEO:0000199 + BTO:0000886 + CALOHA:TS-2031 + EHDAA2_RETIRED:0003234 + EV:0100382 + FMA:85355 + FMA:85358 + GAID:297 + MESH:D009092 + NCIT:C13166 + SCTID:361693009 + Wikipedia:Mucous_membrane + galen:Mucosa mucosa + + + + A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]. + Wikipedia:Mucous_membrane + @@ -104841,8 +155079,30 @@ + Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues. + EHDAA:3015 + EHDAA:3905 + EHDAA:3999 + EHDAA:4005 + EHDAA:6899 + EHDAA:6903 + EHDAA:6994 + EHDAA:8086 + EHDAA:9182 + EHDAA:9190 + EHDAA:9196 + EHDAA:9202 + FMA:45732 + NCIT:C74601 + Wikipedia:Parenchyma parenchyma + + + + Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues. + Wikipedia:Parenchyma + @@ -104867,8 +155127,20 @@ + A mucosa that is part of a pharynx [Automatically generated definition]. + BTO:0001047 + EMAPA:26957 + FMA:55031 + MA:0003143 + SCTID:362121003 pharyngeal mucosa + + + + A mucosa that is part of a pharynx [Automatically generated definition]. + OBOL:automatic + @@ -104912,8 +155184,27 @@ + The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]. + BTO:0001099 + CALOHA:TS-0076 + EFO:0000295 + EMAPA:36035 + EV:0100394 + FMA:83041 + GAID:1153 + MESH:D001755 + NCIT:C13739 + SCTID:308837009 + Wikipedia:Blastocyst blastocyst + + + + The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]. + GO:0001824 + Wikipedia:Blastocyst + @@ -104944,8 +155235,19 @@ + The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream. + BTO:0001160 + FMA:74595 + SCTID:328538003 + SCTID:75330005 red bone marrow + + + + The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream. + http://medical-dictionary.thefreedictionary.com/red+marrow + @@ -104965,8 +155267,24 @@ + Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated). + BTO:0001335 + EHDAA:129 + EHDAA:91 + EMAPA:16068 + FMA:83040 + NCIT:C33918 + SCTID:256965005 + Wikipedia:Syncytiotrophoblast syncytiotrophoblast + + + + Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated). + Wikipedia:Syncytiotrophoblast + http://embryology.med.unsw.edu.au/Notes/placenta5.htm + @@ -104980,9 +155298,27 @@ - + The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses. + AAO:0010670 + BTO:0001378 + EHDAA2:0002087 + EMAPA:17799 + FMA:52724 + GAID:836 + MA:0001103 + MESH:D008442 + SCTID:280211001 + VHOG:0001346 + Wikipedia:Maxillary_nerve maxillary nerve + + + + The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses. + MP:0009799 + Wikipedia:Maxillary_nerve + @@ -105007,8 +155343,18 @@ + A mucosa that is part of a respiratory airway. + BTO:0001390 + FMA:7471 + SCTID:660006 tracheal mucosa + + + + A mucosa that is part of a respiratory airway. + OBOL:automatic + @@ -105045,9 +155391,26 @@ - + The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. + AAO:0000307 + BILA:0000088 + BTO:0001369 + BTO:0001485 + EFO:0000801 + FMA:72954 + MA:0002888 + MAT:0000025 + MIAA:0000025 + VSAO:0000033 + XAO:0004042 musculature of body + + + + The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. + VSAO:0000033 + @@ -105085,9 +155448,20 @@ - + Tissue that surrounds the lens nucleus. + BTO:0001632 + CALOHA:TS-0542 + FMA:58970 + MESH:D007904 + SCTID:280626006 lens cortex + + + + Tissue that surrounds the lens nucleus. + http://www.thefreedictionary.com/lens+cortex + @@ -105125,9 +155499,60 @@ - + The core of the crystalline lens, surrounded by the cortex. + BTO:0001633 + FMA:58971 + MESH:D007907 + SCTID:280628007 lens nucleus + + + + The core of the crystalline lens, surrounded by the cortex. + BTO:0001633 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a colon [Automatically generated definition]. + BTO:0001709 + CALOHA:TS-0163 + EMAPA:18941 + FMA:17302 + MA:0003195 + SCTID:42978003 + TAO:0005128 + ZFA:0005128 + colonic epithelium + + + + + An epithelium that is part of a colon [Automatically generated definition]. + OBOL:automatic + @@ -105164,8 +155589,19 @@ + A gland in which the principal secretory cells are serous secreting cells. + BTO:0001837 + FMA:62889 + Wikipedia:Serous_gland serous gland + + + + A gland in which the principal secretory cells are serous secreting cells. + http://orcid.org/0000-0002-6601-2165 + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -105191,8 +155627,68 @@ + A mucosa that is part of a bronchus [Automatically generated definition]. + BTO:0001846 + FMA:62652 + SCTID:30802009 bronchial mucosa + + + + A mucosa that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A gland in which the principal secretory cells are mucus secreting cells. + AAO:0010601 + BTO:0001979 + FMA:62888 + Wikipedia:Mucous_gland + mucous gland + + + + + A gland in which the principal secretory cells are mucus secreting cells. + http://orcid.org/0000-0002-6601-2165 + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -105217,8 +155713,50 @@ + An anatomical wall that is part of an artery [Automatically generated definition]. + BTO:0002009 + FMA:14155 + galen:ArterialWall artery wall + + + + An anatomical wall that is part of an artery [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]. + BTO:0002501 + FMA:85273 + Wikipedia:Trabecula + trabecula + + + + + A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]. + GO:0060343 + Wikipedia:Trabecula + @@ -105243,8 +155781,24 @@ + A portion of organism substance that is produced by exocrine glands. + AEO:0001005 + BTO:0002977 + BTO:0002979 + EMAPA:36535 + FMA:9675 + MA:0002504 + MESH:D012634 + NCIT:C34062 + galen:Secretion secretion of exocrine gland + + + + A portion of organism substance that is produced by exocrine glands. + http://orcid.org/0000-0002-6601-2165 + @@ -105264,11 +155818,33 @@ - - - + Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. + AAO:0010839 + AEO:0000004 + BILA:0000004 + CALOHA:TS-2101 + CARO:0000004 + EHDAA2:0003004 + EMAPA:35178 + FMA:9669 + HAO:0000004 + MA:0002450 + NCIT:C13236 + SPD:0000008 + TAO:0001487 + TGMA:0001824 + VHOG:0001726 + XAO:0004001 + ZFA:0001487 + galen:BodySubstance organism substance + + + + Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. + http://orcid.org/0000-0001-9114-8737 + @@ -105282,11 +155858,28 @@ - - - + Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. + AAO:0010110 + AEO:0000005 + BILA:0000005 + CARO:0000005 + EHDAA2:0003005 + FMA:5897 + HAO:0000005 + NCIT:C94478 + TAO:0001668 + TGMA:0001825 + VHOG:0001728 + XAO:0003190 + ZFA:0001643 anatomical space + + + + Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. + http://orcid.org/0000-0001-9114-8737 + @@ -105296,11 +155889,25 @@ - - - + Anatomical entity that has mass. + AAO:0010264 + AEO:0000006 + BILA:0000006 + CARO:0000006 + EHDAA2:0003006 + FMA:67165 + HAO:0000006 + TAO:0001836 + TGMA:0001826 + VHOG:0001721 material anatomical entity + + + + Anatomical entity that has mass. + http://orcid.org/0000-0001-9114-8737 + @@ -105309,11 +155916,25 @@ - - - + Anatomical entity that has no mass. + AAO:0010265 + AEO:0000007 + BILA:0000007 + CARO:0000007 + EHDAA2:0003007 + FMA:67112 + HAO:0000007 + TAO:0001835 + TGMA:0001827 + VHOG:0001727 immaterial anatomical entity + + + + Anatomical entity that has no mass. + http://orcid.org/0000-0001-9114-8737 + @@ -105333,12 +155954,40 @@ - - - - + Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. + AAO:0000007 + AEO:0000011 + BILA:0000011 + BIRNLEX:14 + BSA:0000049 + CALOHA:TS-2088 + CARO:0000011 + EHDAA2:0003011 + EHDAA:392 + EMAPA:16103 + EV:0100000 + FMA:7149 + HAO:0000011 + MA:0000003 + NCIT:C12919 + SCTID:278195005 + TAO:0001439 + TGMA:0001831 + VHOG:0001725 + WBbt:0005746 + WBbt:0005763 + Wikipedia:Organ_system + XAO:0003002 + ZFA:0001439 + galen:AnatomicalSystem anatomical system + + + + Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. + CARO:0000011 + @@ -105346,11 +155995,77 @@ - - - + Anatomical structure that is an individual member of a species and consists of more than one cell. + AAO:0010026 + AEO:0000191 + BILA:0000012 + BIRNLEX:18 + BSA:0000038 + BTO:0000042 + CARO:0000012 + EFO:0002906 + EHDAA2:0003103 + EHDAA2:0003191 + EHDAA:1 + EMAPA:25765 + EV:0100016 + FMA:256135 + HAO:0000012 + NCIT:C13041 + SCTID:243928005 + TADS:0000001 + TAO:0001094 + TGMA:0001832 + VHOG:0000671 + WBbt:0007833 + Wikipedia:Multi-cellular_organism + XAO:0003004 + ZFA:0001094 + galen:Organism + ncithesaurus:Whole_Organism multicellular organism + + + + Anatomical structure that is an individual member of a species and consists of more than one cell. + CARO:0000012 + Wikipedia:Multi-cellular_organism + http://orcid.org/0000-0001-9114-8737 + + + + + + + + + + + + + + + Multi-tissue structure that is part of a compound organ. + AAO:0010017 + AEO:0000019 + BILA:0000019 + CARO:0000019 + EHDAA2:0003019 + HAO:0000019 + TAO:0001489 + TGMA:0001835 + XAO:0003039 + ZFA:0001489 + compound organ component + + + + + Multi-tissue structure that is part of a compound organ. + CARO:0000019 + http://orcid.org/0000-0001-9114-8737 + @@ -105375,9 +156090,37 @@ - + The organs and associated structures associated with bearing offspring in a female animal. + BTO:0000083 + CALOHA:TS-1303 + EFO:0000969 + EHDAA2:0000506 + EHDAA:8116 + EMAPA:17959 + EV:0100110 + FMA:45663 + GAID:364 + HAO:0000324 + MA:0000381 + MESH:D005836 + MIAA:0000028 + NCIT:C12402 + SCTID:361386004 + TGMA:0000635 + VHOG:0000726 + Wikipedia:Female_genitalia + WikipediaCategory:Female_reproductive_system + XAO:0000156 female reproductive system + + + + The organs and associated structures associated with bearing offspring in a female animal. + MP:0001119 + Wikipedia:Female_genitalia + http://orcid.org/0000-0002-6601-2165 + @@ -105391,11 +156134,40 @@ - - - + Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. + AAO:0010053 + AEO:0000032 + BILA:0000032 + BIRNLEX:7 + CALOHA:TS-2084 + CARO:0000032 + EFO:0000808 + EHDAA2:0003032 + EMAPA:36031 + FMA:7153 + HAO:0000032 + MA:0002433 + MAT:0000293 + MESH:D001829 + MIAA:0000293 + NCIT:C32221 + TAO:0001308 + TGMA:0001840 + VHOG:0001758 + Wikipedia:Body_part + XAO:0003013 + ZFA:0001308 + galen:BodyPart organism subdivision + + + + Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. + CARO:0000032 + CARO:DOS + http://orcid.org/0000-0001-9114-8737 + @@ -105403,11 +156175,26 @@ - - - + Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. + AAO:0010268 + AEO:0000040 + BILA:0000040 + CARO:0000040 + EHDAA2:0003040 + FMA:63863 + HAO:0000040 + TAO:0000382 + TGMA:0001841 + XAO:0003162 + ZFA:0000382 acellular anatomical structure + + + + Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. + http://orcid.org/0000-0001-9114-8737 + @@ -105415,11 +156202,16 @@ - - - + Anatomical group whose component anatomical structures lie in close proximity to each other. + VHOG:0001737 anatomical cluster + + + + Anatomical group whose component anatomical structures lie in close proximity to each other. + FBbt:00007277 + @@ -105444,8 +156236,34 @@ + A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis. + AAO:0010020 + AEO:0000042 + BILA:0000042 + CALOHA:TS-2119 + CARO:0000042 + EHDAA2:0003042 + EHDAA:46 + FMA:85537 + HAO:0000042 + NCIT:C34055 + SCTID:314908006 + TAO:0000020 + TGMA:0001843 + VHOG:0000292 + XAO:0004005 + ZFA:0000020 + see also conceptus extraembryonic component in EHDAA2. extraembryonic structure + + + + A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis. + CARO:DOS + http://orcid.org/0000-0001-9114-8737 + https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279 + @@ -105465,11 +156283,36 @@ - - - + Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. + AAO:0000607 + AAO:0010054 + AEO:0000043 + BILA:0000043 + BIRNLEX:19 + CALOHA:TS-2090 + CARO:0000043 + EHDAA2:0003043 + EMAPA:35868 + FMA:9637 + HAO:0000043 + MA:0003002 + MESH:D014024 + NCIT:C12801 + TAO:0001477 + TGMA:0001844 + VHOG:0001757 + WBbt:0005729 + XAO:0003040 + ZFA:0001477 + galen:Tissue tissue + + + + Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. + CARO:0000043 + @@ -105483,11 +156326,27 @@ - - - + Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. + AAO:0010048 + AEO:0000055 + BILA:0000055 + CARO:0000055 + EHDAA2:0003055 + HAO:0000055 + TAO:0001488 + TGMA:0001847 + VHOG:0001762 + XAO:0003037 + ZFA:0001488 multi-tissue structure + + + + Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. + CARO:0000055 + http://orcid.org/0000-0001-9114-8737 + @@ -105538,8 +156397,38 @@ + Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. + AAO:0000144 + AAO:0010055 + AEO:0000066 + BILA:0000066 + BTO:0000416 + CALOHA:TS-0288 + CARO:0000066 + EHDAA2:0003066 + EMAPA:32738 + FMA:9639 + GAID:402 + HAO:0000066 + MA:0003060 + MESH:D004848 + NCIT:C12710 + SCTID:31610004 + TAO:0001486 + VHOG:0000387 + Wikipedia:Epithelium + XAO:0003045 + ZFA:0001486 + Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it? epithelium + + + + Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. + Wikipedia:Epithelium + http://orcid.org/0000-0001-9114-8737 + @@ -105548,8 +156437,28 @@ + Unilaminar epithelium that consists of a single layer of cuboidal cells. + AAO:0010064 + AEO:0000067 + BILA:0000067 + CARO:0000067 + EHDAA2:0003067 + FMA:45566 + HAO:0000067 + NCIT:C33553 + TAO:0001497 + Wikipedia:Simple_cuboidal_epithelium + XAO:0004009 + ZFA:0001497 simple cuboidal epithelium + + + + Unilaminar epithelium that consists of a single layer of cuboidal cells. + Wikipedia:Simple_cuboidal_epithelium + http://orcid.org/0000-0001-9114-8737 + @@ -105558,8 +156467,30 @@ + Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]. + AAO:0010063 + AEO:0000068 + BILA:0000068 + CARO:0000068 + EHDAA2_RETIRED:0003068 + FMA:45567 + HAO:0000068 + NCIT:C33552 + SCTID:32210007 + TAO:0001496 + Wikipedia:Simple_columnar_epithelium + XAO:0004008 + ZFA:0001496 simple columnar epithelium + + + + Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]. + FMA:FMA + Wikipedia:Simple_columnar_epithelium + http://orcid.org/0000-0001-9114-8737 + @@ -105567,8 +156498,31 @@ + Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]. + AAO:0010059 + AEO:0000069 + BILA:0000069 + BTO:0002074 + CARO:0000069 + EHDAA2:0003069 + FMA:45562 + HAO:0000069 + NCIT:C33622 + SCTID:309044005 + TAO:0001494 + Wikipedia:Stratified_epithelium + XAO:0004006 + ZFA:0001494 multilaminar epithelium + + + + Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]. + FMA:FMA + Wikipedia:Stratified_epithelium + http://orcid.org/0000-0001-9114-8737 + @@ -105588,8 +156542,30 @@ + Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]. + AAO:0010066 + AEO:0000070 + BILA:0000070 + BTO:0002073 + CARO:0000070 + EHDAA2:0003070 + FMA:45565 + HAO:0000070 + NCIT:C13178 + TAO:0001498 + Wikipedia:Simple_squamous_epithelium + XAO:0004010 + ZFA:0001498 simple squamous epithelium + + + + Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]. + FMA:45565 + Wikipedia:Simple_squamous_epithelium + http://orcid.org/0000-0001-9114-8737 + @@ -105597,8 +156573,25 @@ + Epithelium that consists of epithelial cells not arranged in one ore more layers. + AAO:0010057 + AEO:0000071 + BILA:0000071 + CARO:0000071 + EHDAA2:0003071 + FMA:61741 + HAO:0000071 + TAO:0001493 + XAO:0004004 + ZFA:0001493 atypical epithelium + + + + Epithelium that consists of epithelial cells not arranged in one ore more layers. + http://orcid.org/0000-0001-9114-8737 + @@ -105623,8 +156616,27 @@ + Compound organ that contains one or more macroscopic anatomical spaces. + AAO:0010016 + AEO:0000072 + BILA:0000072 + CARO:0000072 + EHDAA2:0003072 + FMA:55671 + HAO:0000072 + TAO:0001490 + TGMA:0001857 + VHOG:0001730 + XAO:0003165 + ZFA:0001490 cavitated compound organ + + + + Compound organ that contains one or more macroscopic anatomical spaces. + http://orcid.org/0000-0001-9114-8737 + @@ -105632,8 +156644,72 @@ + Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]. + AAO:0010062 + AEO:0000073 + BILA:0000073 + BTO:0002073 + CARO:0000073 + EHDAA2:0003073 + FMA:45561 + HAO:0000073 + NCIT:C33554 + SCTID:309043004 + TAO:0001495 + XAO:0004007 + ZFA:0001495 unilaminar epithelium + + + + Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]. + FMA:45561 + http://orcid.org/0000-0001-9114-8737 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water. + CALOHA:TS-2144 + ENVO:02000040 + FMA:66938 + GAID:1164 + MESH:D009093 + NCIT:C13259 + Wikipedia:Mucus + galen:Mucus + mucus + + + + + Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water. + Wikipedia:Mucus + @@ -105659,8 +156735,20 @@ + Subdivision of trunk that lies between the head and the abdomen. + EMAPA:35862 + FMA:259209 + MA:0000022 + SCTID:302551006 + Wikipedia:Thorax thoracic segment of trunk + + + + Subdivision of trunk that lies between the head and the abdomen. + http://orcid.org/0000-0002-6601-2165 + @@ -105680,8 +156768,29 @@ + The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column. + BTO:0000020 + CALOHA:TS-0001 + EFO:0000968 + EMAPA:35102 + EV:0100011 + FMA:9577 + GAID:16 + MA:0000029 + MAT:0000298 + MESH:D000005 + MIAA:0000298 + SCTID:302553009 + Wikipedia:Abdomen + galen:Abdomen abdomen + + + + The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column. + http://orcid.org/0000-0002-6601-2165 + @@ -105716,8 +156825,43 @@ + Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + AAO:0011035 + AEO:0000169 + BILA:0000056 + BSA:0000039 + BTO:0000379 + CALOHA:TS-0229 + EFO:0001367 + EHDAA2:0000002 + EHDAA2_RETIRED:0003236 + EHDAA:38 + EMAPA:16039 + FMA:69068 + GAID:963 + MAT:0000226 + MESH:D004622 + MIAA:0000019 + NCIT:C28147 + OGEM:000001 + SCTID:57991002 + VHOG:0001766 + Wikipedia:Embryo + XAO:0000113 + ZFA:0000103 + http://neurolex.org/wiki/Category:Embryonic_organism embryo + + + + Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + BTO:0000379 + FB:FBrf0039741 + FB:FBrf0041814 + GO:0009790 + Wikipedia:Embryo + @@ -105731,8 +156875,31 @@ + A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. + AAO:0000480 + BILA:0000035 + BTO:0000556 + EMAPA:36033 + FMA:69069 + GAID:1303 + MESH:D005855 + NCIT:C12950 + NCIT:C54105 + TAO:0001122 + VHOG:0001223 + Wikipedia:Germ_layer + XAO:0003011 + ZFA:0001122 + Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest] germ layer + + + + A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. + Wikipedia:Germ_layer + https://github.com/obophenotype/uberon/issues/203 + @@ -105752,8 +156919,36 @@ + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. + AAO:0000137 + BILA:0000036 + BTO:0000315 + CALOHA:TS-0216 + EFO:0000414 + EHDAA2:0000428 + EMAPA:16069 + EV:0100003 + FMA:69070 + GAID:1304 + MAT:0000155 + MAT:0000173 + MESH:D004475 + MIAA:0000173 + NCIT:C12703 + SCTID:362851007 + TAO:0000016 + VHOG:0000153 + Wikipedia:Ectoderm + XAO:0000001 + ZFA:0000016 ectoderm + + + + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. + Wikipedia:Ectoderm + @@ -105773,8 +156968,35 @@ + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. + AAO:0000139 + BILA:0000038 + BTO:0000800 + CALOHA:TS-0273 + EFO:0002545 + EHDAA2:0000436 + EMAPA:16062 + EV:0100005 + FMA:69071 + GAID:1305 + MAT:0000175 + MESH:D004707 + MIAA:0000175 + NCIT:C12706 + SCTID:362855003 + TAO:0000017 + VHOG:0000154 + Wikipedia:Endoderm + XAO:0000090 + ZFA:0000017 endoderm + + + + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. + Wikipedia:Endoderm + @@ -105794,8 +157016,38 @@ + The middle germ layer of the embryo, between the endoderm and ectoderm. + AAO:0000304 + BILA:0000037 + BTO:0000839 + CALOHA:TS-0623 + EFO:0001981 + EHDAA2:0001128 + EHDAA:124 + EHDAA:160 + EHDAA:183 + EMAPA:16083 + EV:0100006 + FMA:69072 + GAID:522 + MAT:0000174 + MESH:D008648 + MIAA:0000174 + NCIT:C12750 + SCTID:362854004 + TAO:0000041 + VHOG:0000152 + Wikipedia:Mesoderm + XAO:0000050 + ZFA:0000041 mesoderm + + + + The middle germ layer of the embryo, between the endoderm and ectoderm. + Wikipedia:Mesoderm + @@ -105821,8 +157073,84 @@ + Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. + BTO:0004224 + EHDAA2:0001929 + EMAPA:16263 + FMA:295846 + NCIT:C34306 + TAO:0001290 + TGMA:0000135 + Wikipedia:Stomodeum + XAO:0000269 + ZFA:0001290 stomodeum + + + + Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. + Wikipedia:Stomodeum + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/326 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract. + AAO:0011087 + EHDAA2:0000121 + EMAPA:25038 + NCIT:C34278 + TAO:0000066 + VHOG:0000139 + Wikipedia:Proctodeum + XAO:0001019 + ZFA:0000066 + proctodeum + + + + + Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract. + ZFA:0000066 + https://github.com/obophenotype/uberon/issues/685 + https://sourceforge.net/p/fbbtdv/tickets/52 + @@ -105855,9 +157183,39 @@ - + An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium. + AAO:0000579 + ANISEED:1235297 + BTO:0001307 + CALOHA:TS-0980 + EFO:0000837 + EHDAA2:0001915 + EHDAA:2993 + EMAPA:17021 + EV:0100070 + FMA:7148 + GAID:293 + MA:0000353 + MAT:0000051 + MESH:D013270 + MIAA:0000051 + NCIT:C12391 + SCTID:181246003 + TAO:0002121 + VHOG:0000408 + Wikipedia:Stomach + XAO:0000128 + galen:Stomach stomach + + + + An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium. + ISBN:0073040584 + Wikipedia:Stomach + https://orcid.org/0000-0002-6601-2165 + @@ -105879,9 +157237,37 @@ - + The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation. + AAO:0010213 + BTO:0000135 + CALOHA:TS-0046 + EFO:0000265 + EMAPA:18601 + EV:0100027 + FMA:3734 + GAID:469 + MA:0000062 + MAT:0000035 + MESH:D001011 + MIAA:0000035 + NCIT:C12669 + SCTID:181298001 + VHOG:0001523 + Wikipedia:Aorta + XAO:0003010 + galen:Aorta aorta + + + + The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation. + ISBN:0-683-40008-8 + MESH:A07.231.114.056 + MP:0000272 + Wikipedia:Aorta + http://orcid.org/0000-0002-6601-2165 + @@ -105933,9 +157319,40 @@ - + A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. + AAO:0010210 + BILA:0000020 + BTO:0000562 + CALOHA:TS-0445 + EFO:0000815 + EHDAA2:0000738 + EHDAA:420 + EMAPA:16105 + EV:0100018 + FMA:7088 + GAID:174 + MA:0000072 + MAT:0000036 + MESH:D006321 + MIAA:0000036 + NCIT:C12727 + SCTID:302509004 + TAO:0000114 + VHOG:0000276 + Wikipedia:Heart + XAO:0000064 + ZFA:0000114 + galen:Heart + Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 heart + + + + A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. + Wikipedia:Heart + http://orcid.org/0000-0002-6601-2165 + @@ -105968,14 +157385,41 @@ + + + Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. + AAO:0010279 + CALOHA:TS-1301 + EFO:0002969 + EHDAA2:0002224 + EMAPA:35306 + EV:0100128 + FMA:9668 + GAID:439 + MA:0000012 + MESH:D004703 + NCIT:C12705 + SCTID:278876000 + TAO:0001158 + VHOG:0000098 + Wikipedia:Endocrine_system + XAO:0000158 + ZFA:0001158 endocrine system + + + + Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. + NLM:endocrine+system + Wikipedia:Endocrine_system + @@ -106020,9 +157464,49 @@ - + The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. + AAO:0010478 + ABA:Brain + BAMS:Br + BAMS:Brain + BILA:0000135 + BIRNLEX:796 + BTO:0000142 + CALOHA:TS-0095 + DHBA:10155 + EFO:0000302 + EHDAA2:0000183 + EHDAA:2641 + EHDAA:6485 + EMAPA:16894 + EV:0100164 + FMA:50801 + GAID:571 + HBA:4005 + MA:0000168 + MAT:0000098 + MBA:8 + MBA:997 + MESH:D001921 + MIAA:0000098 + NCIT:C12439 + PBA:3999 + SCTID:258335003 + TAO:0000008 + VHOG:0000157 + Wikipedia:Brain + XAO:0000010 + ZFA:0000008 + galen:Brain brain + + + + The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. + Wikipedia:Brain + https://github.com/obophenotype/uberon/issues/300 + @@ -106047,8 +157531,16 @@ + Any thin layer or plate. + Wikipedia:Lamina_of_the_vertebral_arch lamina + + + + Any thin layer or plate. + Wikipedia:Lamina_of_the_vertebral_arch + @@ -106073,9 +157565,23 @@ - + The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]. + BAMS:cern + FMA:5859 + NCIT:C32299 + NLXANAT:20090207 + SCTID:360497008 + Wikipedia:Cervical_nerves + neuronames:2351 + Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP] nerve of cervical vertebra + + + + The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]. + Wikipedia:Cervical_nerves + @@ -106100,6 +157606,8 @@ + MAT:0000204 + MIAA:0000204 head sensillum @@ -106176,9 +157684,36 @@ - + The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure. + AAO:0010344 + BTO:0000286 + CALOHA:TS-0171 + EFO:0000377 + EHDAA2:0000316 + EHDAA:10199 + EMAPA:17161 + EV:0100341 + FMA:58238 + GAID:892 + MA:0000266 + MESH:D003315 + NCIT:C12342 + SCTID:181162001 + TAO:0000640 + VHOG:0000164 + Wikipedia:Cornea + XAO:0000180 + ZFA:0000640 cornea + + + + The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure. + ISBN:0-683-40008-8 + MESH:A09.371.060.217 + MP:0001312 + @@ -106211,9 +157746,36 @@ - + A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina. + AAO:0010348 + BTO:0000723 + CALOHA:TS-0545 + EHDAA:9057 + EMAPA:17838 + EV:0100343 + FMA:58241 + MA:0000275 + MAT:0000141 + MESH:D007908 + MIAA:0000141 + NCIT:C12743 + RETIRED_EHDAA2:0000975 + SCTID:181169005 + TAO:0000035 + VHOG:0000169 + Wikipedia:Lens_(anatomy) + XAO:0000008 + ZFA:0000035 + The lens is avascular and nourished by diffusion from the aqueous and vitreous humors. lens of camera-type eye + + + + A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina. + Wikipedia:Lens_(anatomy) + http://orcid.org/0000-0002-6601-2165 + @@ -106258,9 +157820,43 @@ - + The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + AAO:0010352 + BAMS:R + BIRNLEX:1153 + BTO:0001175 + CALOHA:TS-0865 + EFO:0000832 + EHDAA2:0001627 + EHDAA:4757 + EMAPA:17168 + EV:0100348 + FMA:58301 + GAID:755 + MA:0000276 + MAT:0000142 + MBA:304325711 + MESH:D012160 + MIAA:0000142 + NCIT:C12343 + NIFSTD_RETIRED:birnlex_1156 + SCTID:181171005 + TAO:0000152 + VHOG:0000229 + Wikipedia:Retina + XAO:0000009 + ZFA:0000152 + neuronames:1862 + Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods retina + + + + The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + Wikipedia:Retina + ZFIN:curator + @@ -106292,9 +157888,25 @@ - + An organ that detects light. + BILA:0000017 + BTO:0000439 + CALOHA:TS-0309 + EFO:0000827 + EV:0100336 + GAID:69 + MAT:0000140 + MESH:D005123 + MIAA:0000140 + Wikipedia:Eye eye + + + + An organ that detects light. + https://orcid.org/0000-0002-6601-2165 + @@ -106309,8 +157921,20 @@ + The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells. + BTO:0001922 + HAO:0000666 + MAT:0000143 + MIAA:0000143 + Wikipedia:Ommatidium ommatidium + + + + The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells. + PMID:21062451 + @@ -106336,8 +157960,31 @@ + An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column. + AEO:0000108 + BTO:0000420 + CALOHA:TS-2045 + EFO:0000967 + EHDAA2:0003108 + EMAPA:35587 + FMA:7155 + GAID:86 + MA:0000024 + MAT:0000297 + MESH:D009333 + MIAA:0000297 + NCIT:C13063 + SCTID:302550007 + Wikipedia:Neck + galen:Neck neck + + + + An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column. + http://orcid.org/0000-0002-6601-2165 + @@ -106407,8 +158054,31 @@ + The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion). + BTO:0001791 + CALOHA:TS-2081 + EFO:0001980 + EV:0100044 + FMA:9583 + GAID:360 + MA:0000433 + MESH:D010994 + NCIT:C12469 + SCTID:181609007 + VHOG:0000394 + Wikipedia:Pleura pleura + + + + The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion). + ISBN:0-683-40008-8 + MP:0010820 + UBERON:cjm + Wikipedia:Pulmonary_pleurae + https://github.com/obophenotype/uberon/issues/1231 + @@ -106437,8 +158107,39 @@ + Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. + AEO:0000182 + BTO:0001686 + CALOHA:TS-2023 + EFO:0000948 + EMAPA:35456 + FMA:7490 + GAID:102 + MA:0000319 + MAT:0000188 + MESH:D007596 + MIAA:0000188 + NCIT:C13044 + RETIRED_EHDAA2:0003182 + SCTID:302536002 + TAO:0000367 + VHOG:0001276 + VSAO:0000101 + Wikipedia:Joint + XAO:0000171 + ZFA:0001596 + galen:Joint skeletal joint + + + + Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. + GO_REF:0000034 + VSAO:0000101 + Wikipedia:Joint + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -106476,9 +158177,38 @@ - + The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. + BAMS:PONS + BAMS:Pons + BIRNLEX:733 + BM:Pons + BTO:0001101 + CALOHA:TS-0813 + DHBA:10661 + EFO:0001394 + EHDAA2:0004394 + EMAPA:17563 + EV:0100253 + FMA:67943 + GAID:578 + HBA:9131 + MA:0000204 + MAT:0000115 + MBA:771 + MESH:D011149 + MIAA:0000115 + NCIT:C12511 + SCTID:279103004 + VHOG:0001176 + Wikipedia:Pons pons + + + + The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. + VHOG:0001176 + @@ -106521,15 +158251,46 @@ + + - + Anatomical system that has as its parts the organs concerned with reproduction. + AAO:0010258 + BILA:0000103 + BTO:0000081 + CALOHA:TS-1318 + EFO:0000809 + EHDAA2:0001603 + EHDAA:5923 + EMAPA:17381 + EV:0100100 + FMA:7160 + GAID:363 + HAO:0000374 + HAO:0000895 + MA:0000326 + MIAA:0000305 + NCIT:C12841 + SCTID:278875001 + TAO:0000632 + VHOG:0000182 + WBbt:0005747 + Wikipedia:Reproductive_system + XAO:0000142 + ZFA:0000632 reproductive system + + + + Anatomical system that has as its parts the organs concerned with reproduction. + Wikipedia:Reproductive_system + @@ -106566,8 +158327,36 @@ + Reproductive organ that produces and releases eggs (ovary) or sperm (testis). + AAO:0000213 + BILA:0000123 + BSA:0000079 + BTO:0000534 + EMAPA:17383 + FMA:18250 + GAID:368 + HAO:0000379 + MA:0002420 + MESH:D006066 + NCIT:C12725 + SCTID:304623008 + TAO:0000413 + VHOG:0000397 + WBbt:0005175 + Wikipedia:Gonad + XAO:0003146 + ZFA:0000413 gonad + + + + Reproductive organ that produces and releases eggs (ovary) or sperm (testis). + ISBN:0140512888 + Wikipedia:Gonad + ZFA:0000413 + ZFIN:curator + @@ -106600,9 +158389,39 @@ - + The gonad of a female organism which contains germ cells. + AAO:0000371 + BILA:0000125 + BSA:0000080 + BTO:0000975 + CALOHA:TS-0730 + EFO:0000973 + EHDAA2:0001360 + EHDAA:8124 + EMAPA:17962 + EV:0100111 + FMA:7209 + GAID:367 + MA:0000384 + MESH:D010053 + MIAA:0000125 + NCIT:C12404 + SCTID:181464007 + TAO:0000403 + VHOG:0000251 + Wikipedia:Ovary + XAO:0000258 + ZFA:0000403 ovary + + + + The gonad of a female organism which contains germ cells. + ISBN:0-683-40008-8 + MP:0001126 + Wikipedia:Ovary + @@ -106640,9 +158459,35 @@ - + The outer epithelial layer of the skin that is superficial to the dermis. + AAO:0000143 + BTO:0000404 + CALOHA:TS-0283 + EFO:0000954 + EMAPA:17528 + EV:0100153 + FMA:70596 + GAID:932 + MA:0000153 + MAT:0000154 + MESH:D004817 + MIAA:0000154 + NCIT:C12708 + SCTID:361694003 + TAO:0000105 + VHOG:0000077 + Wikipedia:Epidermis_(skin) + XAO:0000028 + ZFA:0000105 skin epidermis + + + + The outer epithelial layer of the skin that is superficial to the dermis. + ISBN:0073040584 + http://orcid.org/0000-0002-6601-2165 + @@ -106690,15 +158535,45 @@ + + - + Functional system which consists of structures involved in respiration. + AAO:0000541 + BTO:0000203 + CALOHA:TS-1319 + EFO:0000804 + EHDAA2:0001604 + EHDAA:2203 + EMAPA:16727 + EV:0100036 + FMA:7158 + GAID:78 + MA:0000327 + MAT:0000030 + MESH:D012137 + MIAA:0000030 + NCIT:C12779 + SCTID:278197002 + TAO:0000272 + VHOG:0000202 + Wikipedia:Respiratory_system + XAO:0000117 + ZFA:0000272 respiratory system + + + + Functional system which consists of structures involved in respiration. + Wikipedia:Respiratory_system + http://orcid.org/0000-0002-6601-2165 + @@ -106719,8 +158594,17 @@ + An airway through which respiratory air passes in organisms. + SCTID:361380005 + Wikipedia:Trachea respiratory airway + + + + An airway through which respiratory air passes in organisms. + Wikipedia:Trachea + @@ -106755,15 +158639,118 @@ + + - + Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. + AAO:0000129 + BILA:0000082 + BTO:0000058 + CALOHA:TS-1293 + EFO:0000793 + FMA:7152 + GAID:278 + MA:0002431 + MAT:0000018 + MESH:D004064 + MIAA:0000018 + SCTID:278859004 + TADS:0000170 + TAO:0000339 + WBbt:0005748 + Wikipedia:Digestive_system + XAO:0000125 + ZFA:0000339 + galen:DigestiveSystem + ncithesaurus:Digestive_System digestive system + + + + Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. + FB:gg + NLM:alimentary+system + Wikipedia:Digestive_system + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. + AAO:0010257 + BILA:0000015 + BTO:0001244 + BTO:0003092 + CALOHA:TS-1323 + EFO:0000803 + EHDAA2:0001601 + EHDAA:5901 + EMAPA:17366 + EV:0100095 + FMA:7159 + GAID:391 + MA:0000325 + MAT:0000027 + MESH:D014551 + MIAA:0000027 + NCIT:C12413 + SCTID:362204003 + TADS:0000162 + TAO:0000163 + VHOG:0000723 + WBbt:0005736 + Wikipedia:Excretory_system + XAO:0000143 + ZFA:0000163 + galen:UrinaryTract + EDITOR_NOTE In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here + renal system + + + + + The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. + DOI:10.1371/journal.pone.0099864 + GO:0072001 + @@ -106792,15 +158779,27 @@ + + - + Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. + AAO:0000959 + CALOHA:TS-2103 + VHOG:0001248 + Wikipedia:Circulatory_system circulatory system + + + + Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. + Wikipedia:Circulatory_system + @@ -106826,9 +158825,41 @@ - + Portion of connective tissue composed of adipocytes enmeshed in areolar tissue. + AAO:0000001 + AEO:000020 + BTO:0001487 + CALOHA:TS-0013 + EFO:0000790 + EHDAA2:0003120 + EMAPA:35112 + EV:0100381 + FMA:20110 + GAID:920 + MA:0000009 + MAT:0000015 + MESH:D000273 + MIAA:0000015 + NCIT:C12472 + SCTID:55603005 + TAO:0002134 + VHOG:0001284 + Wikipedia:Adipose_tissue + XAO:0003049 + ZFA:0005345 + galen:FattyTissue adipose tissue + + + + Portion of connective tissue composed of adipocytes enmeshed in areolar tissue. + MESH:A10.165.114 + MGI:cwg + MP:0000003 + Wikipedia:Adipose_tissue + http://orcid.org/0000-0002-6601-2165 + @@ -106848,8 +158879,27 @@ + A subdivision of the muscular system corresponding to a subdisivision of an organism. + BTO:0000887 + EFO:0001949 + EMAPA:35577 + FMA:32558 + MA:0000165 + NCIT:C13056 + TAO:0000548 + VSAO:0005038 + WBbt:0005737 + Wikipedia:Muscular_system + ZFA:0000548 musculature + + + + A subdivision of the muscular system corresponding to a subdisivision of an organism. + Wikipedia:Muscular_system + https://orcid.org/0000-0002-6601-2165 + @@ -106895,15 +158945,54 @@ + + - + The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. + AAO:0000324 + BILA:0000079 + BIRNLEX:844 + BTO:0001484 + CALOHA:TS-1313 + EFO:0000802 + EHDAA2:0001246 + EHDAA:826 + EMAPA:16469 + EV:0100162 + FMA:7157 + GAID:466 + MA:0000016 + MAT:0000026 + MESH:D009420 + MIAA:0000026 + NCIT:C12755 + SCTID:278196006 + TAO:0000396 + VHOG:0000402 + WBbt:0005735 + Wikipedia:Nervous_system + XAO:0000177 + ZFA:0000396 + neuronames:3236 nervous system + + + + The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. + BIRNLEX:844 + ISBN:0-14-051288-8 + ISBN:3110148986 + NLM:nervous+system + WB:rynl + Wikipedia:Nervous_system + ZFIN:curator + @@ -106930,9 +159019,42 @@ - + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. + AAO:0000090 + BAMS:CNS + BILA:0000080 + BIRNLEX:1099 + BTO:0000227 + CALOHA:TS-0150 + EFO:0000908 + EHDAA2:0000225 + EHDAA:828 + EMAPA:16470 + EMAPA:16754 + EV:0100163 + FMA:55675 + GAID:570 + MA:0000167 + MAT:0000457 + MESH:D002490 + NCIT:C12438 + SCTID:278199004 + TAO:0000012 + VHOG:0000293 + Wikipedia:Central_nervous_system + XAO:0000215 + ZFA:0000012 + neuronames:854 central nervous system + + + + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. + GO:0021551 + http://www.frontiersinzoology.com/content/7/1/29 + https://sourceforge.net/p/geneontology/ontology-requests/11422/ + @@ -106952,9 +159074,50 @@ - + An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures. + AAO:0011070 + AEO:0000137 + BAMS:n + BIRNLEX:1615 + BSA:0000098 + BTO:0000925 + BTO:0001027 + CALOHA:TS-0772 + EHDAA2:0003137 + EHDAA:2851 + EHDAA:3776 + EHDAA:4657 + EMAPA:32808 + EMAPA:32815 + EV:0100371 + FMA:65132 + FMA:65239 + GAID:747 + GAID:758 + MA:0000217 + MA:0000228 + MESH:D010525 + NCIT:C12466 + NCIT:C12768 + NLX:147826 + SCTID:244457007 + SCTID:256864008 + TAO:0007009 + VHOG:0000901 + Wikipedia:Nervous_system + XAO:0000204 + XAO:0003047 + ZFA:0007009 + galen:Nerve nerve + + + + An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures. + FBbt:00005105 + http://orcid.org/0000-0002-6601-2165 + @@ -106968,8 +159131,20 @@ + A nerve that transmits from sensory receptors on the surface of the body to the central nervous system. + AEO:0000201 + EHDAA2:0003200 + FMA:5868 + Wikipedia:Sensory_nerve sensory nerve + + + + A nerve that transmits from sensory receptors on the surface of the body to the central nervous system. + UBERON:cjm + Wikipedia:Sensory_nerve + @@ -106995,8 +159170,31 @@ + Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. + AAO:0000555 + BAMS:SEN + BILA:0000099 + EFO:0000805 + EHDAA2:0003094 + EMAPA:16192 + FMA:75259 + MA:0002442 + MAT:0000031 + MIAA:0000031 + NLXANAT:090816 + TAO:0000282 + VHOG:0001674 + Wikipedia:Sensory_system + XAO:0003194 + ZFA:0000282 sensory system + + + + Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. + Wikipedia:Sensory_system + @@ -107018,8 +159216,28 @@ + A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]. + BTO:0001471 + CALOHA:TS-1130 + EFO:0003078 + EHDAA2:0002212 + EHDAA:164 + EMAPA:16085 + FMA:87180 + GAID:1301 + MESH:D015017 + NCIT:C14128 + SCTID:362845002 + VHOG:0000830 + Wikipedia:Yolk_sac yolk sac + + + + A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]. + Wikipedia:Yolk_sac + @@ -107027,8 +159245,29 @@ + Anterior subdivision of a digestive tract. + AAO:0011042 + BILA:0000085 + BTO:0000507 + EHDAA2:0000557 + EHDAA:520 + EMAPA:16548 + FMA:45616 + MA:0001526 + NCIT:C34180 + SCTID:361409009 + TGMA:0001014 + VHOG:0000285 + Wikipedia:Foregut + XAO:0000232 foregut + + + + Anterior subdivision of a digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -107054,8 +159293,36 @@ + A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]. + AAO:0000967 + BTO:0001049 + CALOHA:TS-0785 + EFO:0000836 + EHDAA2:0001458 + EHDAA:2947 + EMAPA:16706 + EV:0100065 + FMA:46688 + GAID:155 + MA:0000432 + MESH:D010614 + NCIT:C12425 + SCTID:181211006 + TAO:0000056 + VHOG:0000462 + Wikipedia:Pharynx + XAO:0003227 + ZFA:0000056 + galen:Pharynx + Consider generalizing to deuterostome pharynx chordate pharynx + + + + A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]. + http://www.feedexp.org + @@ -107083,9 +159350,118 @@ - + Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). + AAO:0000145 + ANISEED:1235301 + BTO:0000959 + CALOHA:TS-0700 + EFO:0000835 + EHDAA2:0001285 + EHDAA:2937 + EMAPA:16833 + EV:0100069 + FMA:7131 + GAID:291 + MA:0000352 + MAT:0000048 + MESH:D004947 + MIAA:0000048 + NCIT:C12389 + SCTID:181245004 + TAO:0000204 + VHOG:0000450 + Wikipedia:Esophagus + XAO:0000127 + ZFA:0000204 + galen:Esophagus esophagus + + + + Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). + Wikipedia:Esophagus + http://www.rivm.nl/interspeciesinfo/inter/oesophagus/ + + + + + + + + + + + + + + + Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]. + BILA:0000086 + BTO:0000863 + EFO:0001950 + EHDAA2:0001185 + EHDAA:983 + EMAPA:16255 + FMA:45617 + MA:0001564 + NCIT:C34210 + SCTID:361410004 + TGMA:0001036 + VHOG:0000290 + Wikipedia:Midgut + XAO:0000103 + midgut + + + + + Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]. + GO:0007494 + Wikipedia:Midgut + + + + + + + + + + + + + + + + + + + + + The caudalmost subdivision of a digestive tract. + AAO:0011052 + BILA:0000087 + BTO:0000510 + EHDAA2:0000779 + EHDAA:975 + EMAPA:16715 + FMA:45618 + MA:0001527 + NCIT:C34188 + SCTID:362856002 + TGMA:0001020 + VHOG:0000459 + Wikipedia:Hindgut + XAO:0000104 + hindgut + + + + + The caudalmost subdivision of a digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -107099,8 +159475,27 @@ + Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. + AEO:0000171 + BTO:0001886 + EFO:0001652 + EHDAA2:0003171 + FMA:86589 + MAT:0000482 + NCIT:C34275 + Wikipedia:Primordium + XAO:0003043 primordium + + + + Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. + BTO:0001886 + FB:DJS + FB:FBrf0089570 + http://flybase.org/reports/FBrf0178740.html + @@ -107117,19 +159512,196 @@ + In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. + AAO:0010617 + BTO:0001057 + CALOHA:TS-2371 + DHBA:10154 + EHDAA2:0001254 + EHDAA:2869 + EHDAA:908 + EMAPA:16164 + EMAPA:16757 + FMA:293882 + MAT:0000069 + MIAA:0000069 + NCIT:C34226 + SCTID:362852000 + TAO:0001135 + VHOG:0000307 + Wikipedia:Neural_tube + XAO:0003204 + ZFA:0001135 + neuronames:1365 neural tube + + + + In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. + Wikipedia:Neural_tube + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The terminal portion of the intestinal tube, terminating with the anus. + AAO:0010401 + BTO:0001158 + CALOHA:TS-1180 + EFO:0000848 + EHDAA2:0001592 + EHDAA:5836 + EMAPA:17896 + EV:0100081 + FMA:14544 + GAID:311 + MA:0000336 + MAT:0000050 + MESH:D012007 + MIAA:0000050 + NCIT:C12390 + SCTID:181261002 + VHOG:0001751 + Wikipedia:Rectum + XAO:0000238 + galen:Rectum + rectum + + + + + The terminal portion of the intestinal tube, terminating with the anus. + ISBN:0-683-40008-8 + MP:0000492 + http://orcid.org/0000-0002-6601-2165 + - - - + Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. + AAO:0010841 + AEO:0000000 + BFO:0000004 + BILA:0000000 + BIRNLEX:6 + CARO:0000000 + EHDAA2:0002229 + FMA:62955 + HAO:0000000 + MA:0000001 + NCIT:C12219 + TAO:0100000 + TGMA:0001822 + WBbt:0000100 + XAO:0000000 + ZFA:0100000 anatomical entity + + + + Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. + FMA:62955 + http://orcid.org/0000-0001-9114-8737 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla. + BTO:0002362 + EHDAA2:0001396 + EHDAA:6905 + EMAPA:17510 + FMA:16003 + GAID:337 + MA:0000126 + MESH:D010183 + NCIT:C12272 + RETIRED_EHDAA2:0002177 + SCTID:245385001 + VHOG:0000256 + Wikipedia:Pancreatic_duct + EDITOR_NOTE in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue + ventral pancreatic duct + + + + + A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla. + Wikipedia:Pancreatic_duct + @@ -107154,8 +159726,21 @@ + A zone of skin that is part of a back [Automatically generated definition]. + EMAPA:36392 + FMA:10462 + FMA:22985 + MA:0000498 + SCTID:181492002 + EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region skin of back + + + + A zone of skin that is part of a back [Automatically generated definition]. + OBOL:automatic + @@ -107181,9 +159766,30 @@ - + A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]. + AAO:0010218 + AAO:0010416 + BTO:0004696 + EFO:0001953 + EHDAA2:0000461 + EMAPA:18611 + FMA:10635 + GAID:480 + MA:0001929 + MESH:D002342 + NCIT:C32551 + SCTID:362044002 + VHOG:0000265 + Wikipedia:External_carotid_artery + XAO:0000345 external carotid artery + + + + A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]. + MGI:anna + @@ -107214,9 +159820,21 @@ - + It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery. + FMA:10665 + MA:0002052 + NCIT:C53005 + SCTID:161746006 + Wikipedia:Superficial_part_of_transverse_cervical_artery + The transverse cervical artery splits into two branches, a superficial one and a deep one[WP] superficial cervical artery + + + + It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery. + Wikipedia:Superficial_part_of_transverse_cervical_artery + @@ -107247,9 +159865,82 @@ - + A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart. + AAO:0011083 + BTO:0002682 + EHDAA2:0000611 + EMAPA:18416 + FMA:10951 + GAID:548 + MA:0000480 + MESH:D014682 + NCIT:C12815 + SCTID:181369003 + VHOG:0001194 + Wikipedia:Inferior_vena_cava + XAO:0000388 + galen:InferiorVenaCava inferior vena cava + + + + A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart. + Wikipedia:Inferior_vena_cava + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice. + FMA:11338 + MA:0000332 + SCTID:264021000 + ileocecal junction + + + + + A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice. + http://www.medilexicon.com/medicaldictionary.php?t=46539 + @@ -107299,8 +159990,28 @@ + A potential space between the visceral and parietal layers of the pericardium. + BSA:0000091 + EHDAA2:0001434 + EMAPA:16131 + EMAPA:16132 + FMA:11350 + MA:0000053 + NCIT:C38662 + SCTID:362027001 + TAO:0002220 + VHOG:0000556 + Wikipedia:Pericardial_cavity + ZFA:0001655 + galen:PericardialSpace pericardial cavity + + + + A potential space between the visceral and parietal layers of the pericardium. + Wikipedia:Pericardium + @@ -107333,8 +160044,22 @@ + Endocardium that is part of the cardiac ventricle. + EMAPA:32747 + FMA:12148 + MA:0000079 + SCTID:192172004 + TAO:0002247 + VHOG:0000607 + ZFA:0001615 endocardium of ventricle + + + + Endocardium that is part of the cardiac ventricle. + ZFIN:curator + @@ -107359,8 +160084,18 @@ + An epicardial layer that lines a cardiac ventricle. + FMA:12150 + TAO:0005058 + ZFA:0005058 epicardium of ventricle + + + + An epicardial layer that lines a cardiac ventricle. + http://orcid.org/0000-0002-6601-2165 + @@ -107391,8 +160126,23 @@ + Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer. + EFO:0003088 + EMAPA:32748 + FMA:12151 + MA:0000082 + SCTID:192084000 + TAO:0005061 + VHOG:0000604 + ZFA:0005061 myocardium of ventricle + + + + Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer. + ZFIN:curator + @@ -107417,8 +160167,21 @@ + A zone of skin that is part of a head [Automatically generated definition]. + FMA:12166 + FMA:24756 + MA:0000582 + NCIT:C52757 + SCTID:181484006 + EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region skin of head + + + + A zone of skin that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -107443,8 +160206,21 @@ + A zone of skin that is part of a trunk [Automatically generated definition]. + FMA:12167 + FMA:23093 + MA:0000517 + NCIT:C12295 + SCTID:181489001 + EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region skin of trunk + + + + A zone of skin that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -107469,8 +160245,21 @@ + Transudate contained in the pleural cavity. + BTO:0003080 + FMA:12273 + MA:0002532 + MAT:0000500 + Wikipedia:Pleural_fluid + ncithesaurus:Pleural_Fluid pleural fluid + + + + Transudate contained in the pleural cavity. + FMA:12273 + @@ -107508,8 +160297,135 @@ + Joint fluid is a transudate of plasma that is actively secreted by synovial cells. + BTO:0001339 + CALOHA:TS-0996 + ENVO:02000039 + FMA:12277 + GAID:265 + MA:0002544 + MESH:D013582 + NCIT:C33718 + TAO:0005154 + Wikipedia:Synovial_fluid + ZFA:0005154 + galen:SynovialFluid synovial fluid + + + + Joint fluid is a transudate of plasma that is actively secreted by synovial cells. + https://www.ncbi.nlm.nih.gov/books/NBK274/ + + + + + + + + + + + + + + + The first vertebral bone in the vertebral column. + AAO:0000709 + EHDAA:10606 + EMAPA:19431 + FMA:12519 + GAID:236 + MA:0001421 + MESH:D001270 + NCIT:C32239 + SCTID:181818007 + TAO:0001167 + Wikipedia:Atlas_(anatomy) + ZFA:0001167 + vertebral bone 1 + + + + + The first vertebral bone in the vertebral column. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + The second vertebral bone in the vertebral column. + EHDAA:10608 + EMAPA:19432 + FMA:12520 + GAID:237 + MA:0001422 + MESH:D001368 + NCIT:C32240 + SCTID:181819004 + TAO:0001168 + Wikipedia:Axis_(anatomy) + ZFA:0001168 + vertebral bone 2 + + + + + The second vertebral bone in the vertebral column. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx). + EMAPA:18374 + FMA:12527 + MA:0000310 + MA:0001420 + NCIT:C32334 + SCTID:361774004 + TAO:0000326 + Wikipedia:Caudal_vertebra + XAO:0003079 + ZFA:0000326 + galen:CoccygealVertebra + Taxon notes In zebrafish, Vertebra bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae + caudal vertebra + + + + + Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx). + http://orcid.org/0000-0002-6601-2165 + @@ -107534,8 +160450,18 @@ + An anatomical wall that is part of a esophagus [Automatically generated definition]. + EMAPA:35326 + FMA:12611 + MA:0002691 wall of esophagus + + + + An anatomical wall that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -107562,8 +160488,187 @@ + A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control. + BTO:0000341 + CALOHA:TS-0198 + EFO:0000937 + EHDAA2:0003495 + EMAPA:17701 + EV:0100376 + FMA:13295 + GAID:158 + MA:0001904 + MAT:0000502 + MESH:D003964 + NCIT:C12702 + SCTID:181614006 + VHOG:0000713 + Wikipedia:Thoracid_diaphragm diaphragm + + + + A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control. + MP:0002279 + + + + + + + + + + + + + + + + Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe. + EMAPA:18306 + FMA:13361 + MA:0000360 + NCIT:C49579 + SCTID:245378000 + Wikipedia:Liver#Lobes + lobe of liver + + + + + Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe. + Wikipedia:Liver#Lobes + + + + + + + + + The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]. + EHDAA2:0001008 + EHDAA:4001 + EMAPA:18311 + FMA:13362 + MA:0000363 + NCIT:C33481 + SCTID:362182008 + TAO:0005173 + VHOG:0001424 + Wikipedia:Right_lobe_of_liver + ZFA:0005173 + right lobe of liver + + + + + The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]. + Wikipedia:Right_lobe_of_liver + + + + + + + + + The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]. + EHDAA2:0001000 + EHDAA:3995 + EMAPA:18307 + FMA:13363 + MA:0000361 + NCIT:C32965 + SCTID:362183003 + TAO:0005172 + VHOG:0001423 + Wikipedia:Left_lobe_of_liver + ZFA:0005172 + left lobe of liver + + + + + The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]. + Wikipedia:Left_lobe_of_liver + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]. + AAO:0000699 + AAO:0000734 + BTO:0000818 + EFO:0001369 + EHDA:10119 + EMAPA:35919 + FMA:13478 + GAID:106 + MA:0002416 + MESH:D013131 + NCIT:C12998 + NCIT:C33588 + NIF_Subcellular:sao1145756102 + SCTID:44300000 + TAO:0001559 + VHOG:0001142 + VSAO:0000185 + Wikipedia:Vertebral_column + XAO:0003074 + ZFA:0001559 + galen:SpinalColumn + vertebral column + + + + + Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]. + VSAO:0000185 + https://orcid.org/0000-0002-6601-2165 + https://sourceforge.net/tracker/?func=detail&aid=3530322&group_id=76834&atid=2257941 + @@ -107601,8 +160706,29 @@ + Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]. + AAO:0010245 + AEO:0000142 + BILA:0000134 + BTO:0000199 + CALOHA:TS-0440 + EHDAA2:0003142 + EMAPA:32688 + FMA:14068 + TAO:0005280 + Wikipedia:Cardiac_muscle + ZFA:0005280 + galen:CardiacMuscle + galen:CardiacMuscleTissue + ncithesaurus:Heart_Muscle cardiac muscle tissue + + + + Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]. + ZFA:0005280 + @@ -107639,8 +160765,21 @@ + Muscle tissue that consists primarily of skeletal muscle fibers. + EMAPA:32716 + FMA:14069 + MA:0002439 + NCIT:C13050 + SCTID:426215008 + Wikipedia:Skeletal_striated_muscle skeletal muscle tissue + + + + Muscle tissue that consists primarily of skeletal muscle fibers. + https://github.com/obophenotype/uberon/issues/324 + @@ -107678,8 +160817,39 @@ + Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]. + AAO:0010244 + AEO:0000141 + BTO:0001260 + CALOHA:TS-0943 + EFO:0000889 + EHDAA2:0003141 + EMAPA:32717 + EV:0100378 + FMA:14070 + GAID:167 + MA:0000166 + MAT:0000303 + MESH:D009130 + MIAA:0000303 + NCIT:C12437 + TAO:0005274 + VHOG:0001246 + WBbt:0005781 + Wikipedia:Smooth_muscle_tissue + XAO:0000175 + ZFA:0005274 + galen:SmoothMuscle + galen:SmoothMuscleTissue smooth muscle tissue + + + + Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]. + GO:0006939 + Wikipedia:Smooth_muscle_tissue + @@ -107715,8 +160885,32 @@ + Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). + AEO:0000111 + BTO:0002422 + CALOHA:TS-1183 + EHDAA2_RETIRED:0003111 + EHDAA:2331 + EHDAA:2349 + EHDAA:295 + EHDAA:6073 + EHDAA:640 + EHDAA:646 + EMAPA:32856 + FMA:14074 + MA:0000565 + NCIT:C33105 + SCTID:361918002 + Wikipedia:Mesothelium mesothelium + + + + Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). + FMA:14074 + Wikipedia:Mesothelium + @@ -107730,8 +160924,150 @@ + A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. + BTO:0001713 + CALOHA:TS-2223 + EFO:0001405 + FMA:14181 + GAID:30 + MESH:D001415 + NCIT:C13062 + SCTID:123961009 + Wikipedia:Dorsum_(anatomy) + galen:Back dorsum + + + + A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. + BSPO:0000063 + UBERONREF:0000006 + Wikipedia:Dorsum_(anatomy) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. + BTO:0002783 + EHDAA2:0001951 + EHDAA:5414 + EMAPA:18643 + FMA:14332 + MA:0002179 + NCIT:C33687 + SCTID:278031001 + VHOG:0000552 + Wikipedia:Superior_mesenteric_vein + superior mesenteric vein + + + + + In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. + Wikipedia:Superior_mesenteric_vein + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Vein that carries blood away from the liver[ZFA]. + AAO:0010216 + EMAPA:19221 + FMA:14337 + GAID:534 + MA:0003015 + MESH:D006503 + NCIT:C32736 + SCTID:278191001 + TAO:0000670 + Wikipedia:Hepatic_vein + XAO:0000387 + ZFA:0000670 + galen:HepaticVein + hepatic vein + + + + + Vein that carries blood away from the liver[ZFA]. + Wikipedia:Hepatic_vein + ZFA:0000670 + https://sourceforge.net/tracker/?func=detail&aid=3565355&group_id=76834&atid=1205376 + @@ -107763,8 +161099,346 @@ + A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries. + EMAPA:18644 + FMA:14346 + MA:0002186 + NCIT:C53058 + SCTID:278193003 + Wikipedia:Ovarian_vein ovarian vein + + + + A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries. + Wikipedia:Ovarian_vein + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct. + EHDAA2:0000333 + EHDAA:3045 + EMAPA:16841 + FMA:14539 + GAID:290 + MA:0000355 + MESH:D003549 + NCIT:C32421 + SCTID:245398005 + TAO:0005166 + VHOG:0000213 + Wikipedia:Cystic_duct + ZFA:0005166 + galen:CysticDuct + cystic duct + + + + + The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct. + ISBN:0-683-40008-8 + MP:0009493 + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal. + AAO:0010400 + BTO:0000269 + CALOHA:TS-0158 + EFO:0000361 + EMAPA:18939 + EV:0100079 + FMA:14543 + GAID:309 + MA:0000335 + MAP:0000001 + MAT:0000526 + MESH:D003106 + NCIT:C12382 + SCTID:302508007 + TAO:0000706 + VHOG:0000648 + Wikipedia:Colon_(anatomy) + XAO:0000243 + ZFA:0000706 + galen:Colon + colon + + + + + A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal. + Wikipedia:Colon_(anatomy) + ZFIN:curator + http://orcid.org/0000-0002-2825-0621 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity. + BTO:0000645 + CALOHA:TS-2044 + EFO:0000846 + EMAPA:36391 + FMA:14548 + MAT:0000314 + MESH:D012809 + MIAA:0000314 + NCIT:C12384 + NCIT:C33550 + SCTID:362166007 + Wikipedia:Sigmoid_colon + galen:SigmoidColon + sigmoid colon + + + + + The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity. + Wikipedia:Sigmoid_colon + + + + + + + + + The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]. + BTO:0000505 + EMAPA:35810 + FMA:14560 + MA:0002559 + NCIT:C12258 + SCTID:362140009 + Wikipedia:Body_of_stomach + galen:GastricCorpus + body of stomach + + + + + The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]. + GO:0014845 + Wikipedia:Body_of_stomach + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells. + BTO:0001732 + EFO:0002555 + EMAPA:17891 + FMA:14579 + GAID:332 + MA:0001624 + MESH:D011706 + NCIT:C12259 + SCTID:362142001 + Wikipedia:Pyloric_antrum + galen:PyloricAntrum + pyloric antrum + + + + + The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells. + ISBN:0-683-40008-8 + MP:0010790 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum. + BTO:0001146 + EHDAA2:0001580 + EHDAA:4860 + EMAPA:17631 + FMA:14581 + GAID:333 + MA:0002560 + MESH:D011708 + NCIT:C12260 + SCTID:362143006 + VHOG:0000420 + Wikipedia:Pylorus + galen:Pylorus + pylorus + + + + + The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum. + MGI:csmith + MP:0010785 + @@ -107795,8 +161469,480 @@ + The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between. + EMAPA:35826 + FMA:14582 + MA:0002692 + SCTID:279995000 + galen:WallOfStomach wall of stomach + + + + The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between. + MGI:csmith + MP:0010783 + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical wall that is part of a small intestine [Automatically generated definition]. + EMAPA:35785 + FMA:14615 + MA:0002696 + NCIT:C33573 + wall of small intestine + + + + + An anatomical wall that is part of a small intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical wall that is part of a large intestine [Automatically generated definition]. + EMAPA:35470 + FMA:14619 + MA:0002695 + wall of large intestine + + + + + An anatomical wall that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]. + FMA:14643 + MA:0001555 + SCTID:245456008 + Wikipedia:Mesentery#Mesentery_.28proper.29 + mesentery of small intestine + + + + + The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]. + Wikipedia:Mesentery#Mesentery_.28proper.29 + + + + + + + + + + + + + + + + + + + + + + The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. + FMA:14653 + MA:0002498 + NCIT:C33341 + portal lobule + + + + + The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. + MP:0008992 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids. + EMAPA:35497 + FMA:14654 + MA:0002496 + NCIT:C32992 + SCTID:272214009 + hepatic acinus + + + + + The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids. + http://orcid.org/0000-0002-6601-2165 + http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_acinus.html + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder. + AAO:0011020 + EMAPA:35172 + FMA:14665 + SCTID:181267003 + Wikipedia:Biliary_tract + XAO:0000455 + The path in many species is as follows: Bile canaliculi -> Canals of Hering (intralobar bile duct) -> interlobular bile ducts -> intrahepatic bile ducts -> left and right hepatic ducts merge to form -> common hepatic duct *exits liver* and joins -> cystic duct (from gall bladder) forming -> common bile duct -> joins with pancreatic duct -> forming ampulla of Vater -> enters duodenum [WP] + biliary tree + + + + + A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder. + DOI:10.1002/ar.20664 + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct. + EHDAA2:0000303 + EHDAA:3981 + EMAPA:17201 + FMA:14667 + GAID:282 + MA:0001631 + MESH:D003135 + NCIT:C12698 + SCTID:362199009 + TAO:0005165 + VHOG:0000214 + Wikipedia:Common_bile_duct + ZFA:0005165 + galen:CommonBileDuct + common bile duct + + + + + The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct. + MGI:csmith + MP:0009495 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]. + EMAPA:19101 + FMA:14668 + GAID:286 + MA:0002660 + MESH:D006500 + NCIT:C32356 + SCTID:245403006 + VHOG:0000220 + Wikipedia:Common_hepatic_duct + common hepatic duct + + + + + Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]. + Wikipedia:Common_hepatic_duct + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct. + EHDAA2:0001727 + EHDAA:3992 + EMAPA:32797 + FMA:14669 + MA:0001639 + NCIT:C33476 + SCTID:245401008 + VHOG:0000217 + right hepatic duct + + + + + The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct. + http://www.medterms.com/script/main/art.asp?articlekey=26034 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct. + EHDAA2:0000941 + EHDAA:3990 + EMAPA:32795 + FMA:14670 + MA:0001638 + NCIT:C32960 + SCTID:245400009 + VHOG:0000218 + left hepatic duct + + + + + The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct. + http://www.medterms.com/script/main/art.asp?articlekey=26035 + @@ -107821,8 +161967,23 @@ + The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space. + EMAPA:16592 + FMA:14703 + SCTID:362702003 + TAO:0005132 + VHOG:0001528 + Wikipedia:Visceral_peritoneum + ZFA:0005132 visceral peritoneum + + + + The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space. + Wikipedia:Peritoneum#Types + http://orcid.org/0000-0002-6601-2165 + @@ -107879,8 +162040,28 @@ + Anatomical cavity bounded by visceral and parietal peritoneum. + BTO:0001782 + EHDAA2:0001446 + EMAPA:16138 + FMA:14704 + GAID:24 + MA:0000054 + MESH:D010529 + NCIT:C12769 + SCTID:181616008 + VHOG:0000852 + Wikipedia:Peritoneal_cavity peritoneal cavity + + + + Anatomical cavity bounded by visceral and parietal peritoneum. + Wikipedia:Peritoneal_cavity + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/86 + @@ -107911,9 +162092,116 @@ - + An artery that supplies an ovary. + EMAPA:18620 + FMA:14761 + MA:0002012 + NCIT:C33242 + SCTID:244280002 + Wikipedia:Ovarian_artery ovarian artery + + + + An artery that supplies an ovary. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An artery that supplies the liver. + BTO:0004307 + EMAPA:17859 + FMA:14769 + GAID:496 + MA:0001963 + MESH:D006499 + NCIT:C32729 + SCTID:76015000 + TAO:0005161 + ZFA:0005161 + galen:HepaticArtery + hepatic artery + + + + + An artery that supplies the liver. + Wikipedia:Hepatic_artery_proper + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An artery that supplies the spleen. + EMAPA:19216 + FMA:14773 + GAID:510 + MA:0001991 + MA:0003177 + MESH:D013157 + NCIT:C33597 + SCTID:244266009 + Wikipedia:Splenic_artery + galen:SplenicArtery + splenic artery + + + + + An artery that supplies the spleen. + http://orcid.org/0000-0002-6601-2165 + @@ -107950,8 +162238,26 @@ + The mucosal layer that lines the stomach. + BTO:0001308 + CALOHA:TS-0404 + EMAPA:35817 + FMA:14907 + GAID:321 + MA:0002683 + MESH:D005753 + NCIT:C32656 + SCTID:362131005 + Wikipedia:Gastric_mucosa + galen:GastricMucosa mucosa of stomach + + + + The mucosal layer that lines the stomach. + http://orcid.org/0000-0002-6601-2165 + @@ -107982,8 +162288,22 @@ + The fibrous connective tissue layer beneath the stomach mucosa. + BTO:0002110 + EMAPA:35825 + FMA:14908 + MA:0002685 + NCIT:C32663 + SCTID:52459002 submucosa of stomach + + + + The fibrous connective tissue layer beneath the stomach mucosa. + MGI:csmith + MP:0010794 + @@ -108014,8 +162334,890 @@ + The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum. + EMAPA:35822 + FMA:14914 + MA:0001626 + NCIT:C32662 + SCTID:1353004 serosa of stomach + + + + The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum. + MGI:csmith + MP:0010793 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]. + AAO:0011093 + EMAPA:19251 + FMA:14916 + MA:0002952 + NCIT:C33433 + SCTID:268073008 + VHOG:0001466 + XAO:0000457 + pyloric sphincter + + + + + A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a small intestine [Automatically generated definition]. + BTO:0001259 + CALOHA:TS-0941 + EMAPA:35780 + FMA:14933 + MA:0002686 + NCIT:C33568 + SCTID:362144000 + mucosa of small intestine + + + + + A mucosa that is part of a small intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Submucosal tissue in the small intestines. + BTO:0002112 + FMA:14934 + MA:0001562 + NCIT:C33572 + SCTID:691000 + Wikipedia:Small_intestinal_submucosa + submucosa of small intestine + + + + + Submucosal tissue in the small intestines. + Wikipedia:Small_intestinal_submucosa + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a small intestine [Automatically generated definition]. + FMA:14938 + MA:0001558 + SCTID:8266009 + serosa of small intestine + + + + + A serous membrane that is part of a small intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a large intestine [Automatically generated definition]. + CALOHA:TS-2106 + EMAPA:35467 + FMA:14969 + MA:0002688 + NCIT:C32926 + mucosa of large intestine + + + + + A mucosa that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a large intestine [Automatically generated definition]. + BTO:0002111 + FMA:14970 + MA:0002690 + NCIT:C32930 + submucosa of large intestine + + + + + A submucosa that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a large intestine [Automatically generated definition]. + FMA:14975 + MA:0001546 + NCIT:C32929 + serosa of large intestine + + + + + A serous membrane that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]. + BTO:0002376 + EMAPA:36522 + FMA:15060 + GAID:314 + MA:0001551 + MESH:D002011 + NCIT:C13010 + SCTID:41298001 + Wikipedia:Brunner's_glands + duodenal gland + + + + + A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]. + Wikipedia:Brunner's_glands + + + + + + + + + + + + + + + + + + + + + + + + + + + The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold. + BTO:0003121 + EMAPA:35784 + FMA:15072 + MA:0001563 + NCIT:C33874 + SCTID:23230007 + TAO:0005125 + Wikipedia:Intestinal_villus + ZFA:0005125 + intestinal villus + + + + + The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold. + MGI:csmith + MGI:rbabiuk + MP:0008108 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. + BTO:0002782 + EHDAA2:0000819 + EHDAA:8712 + EMAPA:18642 + FMA:15391 + MA:0002178 + NCIT:C32782 + SCTID:281055007 + VHOG:0001118 + Wikipedia:Inferior_mesenteric_vein + inferior mesenteric vein + + + + + A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. + Wikipedia:Inferior_mesenteric_vein + + + + + + + + + + + + + + + + + + + + + + + + + + Lamina propria that is part_of the small intestine. + EMAPA:35779 + FMA:15651 + MA:0001554 + NCIT:C49297 + SCTID:63588008 + lamina propria of small intestine + + + + + Lamina propria that is part_of the small intestine. + GOC:Obol + + + + + + + + + + + + + + + + + + + + + + + + + + Mucosal layer that lines the intestine. + BTO:0000642 + EMAPA:35440 + FMA:15695 + GAID:296 + MA:0001537 + MESH:D007413 + NCIT:C49241 + SCTID:362080002 + intestinal mucosa + + + + + Mucosal layer that lines the intestine. + UBERON:cjm + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a wall of intestine [Automatically generated definition]. + FMA:15701 + MA:0001538 + serosa of intestine + + + + + A serous membrane that is part of a wall of intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts. + BTO:0001680 + CALOHA:TS-2005 + EV:0100082 + FMA:15711 + GAID:312 + MA:0000331 + NCIT:C43362 + SCTID:181262009 + TADS:0000066 + TGMA:0001279 + WBbt:0005364 + Wikipedia:Anus + galen:Anus + anus + + + + + Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts. + Wikipedia:Anus + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad. + FMA:15767 + MA:0002668 + NCIT:C32827 + SCTID:83488001 + Wikipedia:Interlobular_bile_ducts + interlobular bile duct + + + + + The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad. + MP:0009500 + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical wall that is part of a intestine [Automatically generated definition]. + BTO:0000647 + EMAPA:35444 + FMA:15949 + MA:0001525 + MA:0002693 + NCIT:C49478 + wall of intestine + + + + + An anatomical wall that is part of a intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct. + EMAPA:35651 + FMA:16011 + MA:0002417 + NCIT:C49268 + SCTID:247604006 + pancreatic acinus + + + + + The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct. + MP:0009145 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]. + AAO:0010112 + BTO:0000988 + CALOHA:TS-0736 + EFO:0000855 + EHDAA2:0001367 + EHDAA:6893 + EMAPA:17503 + EV:0100092 + FMA:7198 + GAID:334 + MA:0000120 + MAT:0000075 + MESH:D010179 + MIAA:0000075 + NCIT:C12393 + SCTID:181277001 + TAO:0000140 + VHOG:0000050 + Wikipedia:Pancreas + XAO:0000136 + ZFA:0000140 + galen:Pancreas + pancreas + + + + + An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]. + GO:0031016 + + + + + + + + + + + + + + + + + + + + + + + + + + + A trabecula that is part of a spleen. + EMAPA:35808 + FMA:16027 + MA:0000758 + NCIT:C33607 + SCTID:61987002 + Wikipedia:Trabeculae_of_spleen + trabecula of spleen + + + + + A trabecula that is part of a spleen. + OBOL:automatic + @@ -108042,8 +163244,21 @@ + Transudate contained in the peritoneal cavity. + BTO:0001031 + EMAPA:35683 + FMA:16515 + MA:0002531 + Wikipedia:Peritoneal_fluid + ncithesaurus:Peritoneal_Fluid peritoneal fluid + + + + Transudate contained in the peritoneal cavity. + FMA:16515 + @@ -108077,8 +163292,386 @@ + The epithelial layer of the stomach . + BTO:0000500 + CALOHA:TS-2068 + EHDAA2:0001918 + EMAPA:17023 + FMA:17091 + MA:0001610 + SCTID:64977002 + VHOG:0001433 epithelium of stomach + + + + The epithelial layer of the stomach . + MP:0000471 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Epithelial layer that lines the intestine. + BTO:0000781 + EMAPA:32873 + FMA:17229 + MA:0001536 + NCIT:C49240 + SCTID:266135004 + TAO:0005124 + Wikipedia:Intestinal_epithelium + ZFA:0005124 + intestinal epithelium + + + + + Epithelial layer that lines the intestine. + UBERON:cjm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a large intestine [Automatically generated definition]. + CALOHA:TS-2105 + EMAPA:35466 + FMA:17301 + MA:0001545 + epithelium of large intestine + + + + + An epithelium that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. + FMA:17523 + MA:0002499 + NCIT:C33342 + SCTID:362192000 + Wikipedia:Portal_triad + portal triad + + + + + A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. + ISBN:0-683-40008-8 + MGI:csmith + MP:0008993 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The functional units of the liver including the lobules. + AAO:0010405 + EHDAA2:0001004 + EHDAA:2201 + EMAPA:17203 + FMA:17540 + MA:0000366 + NCIT:C32735 + SCTID:363535004 + UMLS:C0736268 + VHOG:0000539 + XAO:0000454 + liver parenchyma + + + + + The functional units of the liver including the lobules. + MP:0008986 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers. + EHDAA2:0000999 + EMAPA:17365 + FMA:17543 + MA:0000367 + NCIT:C32733 + SCTID:67435004 + TAO:0005091 + VHOG:0000708 + Wikipedia:Hepatic_sinusoid + ZFA:0005091 + hepatic sinusoid + + + + + Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers. + Wikipedia:Hepatic_sinusoid + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule. + FMA:17545 + MA:0002669 + NCIT:C32255 + SCTID:227002 + SCTID:269922006 + Wikipedia:Canals_of_Hering + intralobular bile duct + + + + + The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule. + MGI:csmith + MP:0009499 + + + + + + + + + + + + + + + + + + + + + The anus and surrounding regions. Encompasses both internal and external regions, where present. + EFO:0000847 + EHDAA2:0000122 + EHDAA:2931 + EMAPA:16831 + MA:0000329 + MAT:0000042 + MIAA:0000042 + NCIT:C32069 + SCTID:362680001 + VHOG:0000395 + WBbt:0006919 + anal region + + + + + The anus and surrounding regions. Encompasses both internal and external regions, where present. + https://orcid.org/0000-0002-6601-2165 + @@ -108109,8 +163702,24 @@ + The outer layer of peritoneum that is attached to the abdominal and pelvic walls. + AAO:0010816 + EMAPA:16591 + FMA:21451 + SCTID:362700006 + TAO:0005131 + VHOG:0001527 + Wikipedia:Parietal_peritoneum + ZFA:0005131 parietal peritoneum + + + + The outer layer of peritoneum that is attached to the abdominal and pelvic walls. + Wikipedia:Peritoneum#Types + http://orcid.org/0000-0002-6601-2165 + @@ -108135,8 +163744,21 @@ + A zone of skin that is part of an abdomen [Automatically generated definition]. + EFO:0000214 + FMA:22988 + FMA:23000 + MA:0000523 + NCIT:C52758 + SCTID:361707007 skin of abdomen + + + + A zone of skin that is part of an abdomen [Automatically generated definition]. + OBOL:automatic + @@ -108161,8 +163783,20 @@ + A zone of skin that is part of a neck [Automatically generated definition]. + FMA:23021 + FMA:23022 + MA:0000590 + NCIT:C52756 + SCTID:361705004 skin of neck + + + + A zone of skin that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -108187,8 +163821,19 @@ + A zone of skin that is part of a thorax [Automatically generated definition]. + FMA:23028 + FMA:23029 + MA:0000564 + SCTID:281723000 skin of thorax + + + + A zone of skin that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -108227,8 +163872,21 @@ + An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions. + FMA:23217 + SCTID:229759004 + VSAO:0000305 + galen:ShoulderGirdle pectoral girdle region + + + + An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions. + FMA:23217 + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + @@ -108277,14 +163935,39 @@ + + + Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. + AAO:0000566 + BTO:0001486 + CALOHA:TS-1320 + EFO:0000806 + EHDAA2:0003168 + EMAPA:35773 + FMA:23881 + MA:0000018 + NCIT:C12788 + TAO:0000434 + VHOG:0001254 + VSAO:0000027 + XAO:0003060 + ZFA:0000434 skeletal system + + + + Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. + GO_REF:0000034 + VSAO:0000027 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -108298,6 +163981,9 @@ + FMA:24218 + SCTID:123852005 + XAO:0000040 subdivision of head @@ -108319,8 +164005,27 @@ + A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc). + BTO:0003369 + CALOHA:TS-2216 + EMAPA:32763 + FMA:24728 + GAID:64 + HAO:0000316 + MA:0002473 + MESH:D005145 + NCIT:C13071 + SCTID:302549007 + Wikipedia:Face + galen:Face face + + + + A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc). + http://orcid.org/0000-0002-6601-2165 + @@ -108345,8 +164050,19 @@ + A zone of skin that is part of a lip [Automatically generated definition]. + FMA:24764 + MA:0001579 + NCIT:C12291 + SCTID:244092005 skin of lip + + + + A zone of skin that is part of a lip [Automatically generated definition]. + OBOL:automatic + @@ -108379,8 +164095,43 @@ + Skeletal element that is composed of bone tissue. + AAO:0000047 + AEO:0000082 + BTO:0000140 + CALOHA:TS-0088 + EFO:0000298 + EHDAA2:0003082 + EMAPA:32782 + ENVO:00002039 + EV:0100140 + FMA:30317 + FMA:5018 + GAID:92 + MA:0001459 + MAT:0000299 + MIAA:0000299 + NCIT:C12366 + SCTID:90780006 + TAO:0001514 + VHOG:0001190 + VSAO:0000057 + Wikipedia:Bone + XAO:0000169 + ZFA:0001514 + galen:Bone bone element + + + + Skeletal element that is composed of bone tissue. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000057 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/277 + @@ -108415,8 +164166,24 @@ + An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. + FMA:34836 + GAID:263 + MA:0001519 + MESH:D017746 + NCIT:C32259 + NCIT:C84388 + SCTID:182238002 + Wikipedia:Articular_capsule + galen:JointCapsule articular capsule + + + + An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. + Wikipedia:Articular_capsule + @@ -108454,9 +164221,24 @@ - + The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]. + EHDAA2:0000147 + EHDAA:9828 + EMAPA:17014 + FMA:3736 + MA:0002570 + NCIT:C32150 + SCTID:181299009 + Wikipedia:Ascending_aorta ascending aorta + + + + The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]. + GO:0035905 + Wikipedia:Ascending_aorta + @@ -108500,9 +164282,26 @@ - + The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery. + BTO:0000157 + EFO:0002526 + EHDAA2:0000132 + EMAPA:17613 + FMA:3768 + GAID:471 + MA:0000475 + SCTID:181300001 + VHOG:0001196 + Wikipedia:Arch_of_aorta arch of aorta + + + + The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery. + ISBN:0-683-40008-8 + MP:0004113 + @@ -108534,9 +164333,22 @@ - + The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]. + EMAPA:18606 + FMA:3784 + MA:0002571 + NCIT:C32455 + SCTID:261399002 + Wikipedia:Descending_aorta descending aorta + + + + The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]. + GO:0035906 + Wikipedia:Descending_aorta + @@ -108567,8 +164379,27 @@ + The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + BTO:0000157 + EFO:0002525 + EMAPA:18603 + FMA:3786 + GAID:471 + MA:0002569 + MESH:D001013 + NCIT:C33766 + SCTID:302510009 + Wikipedia:Thoracic_aorta + galen:ThoracicAorta thoracic aorta + + + + The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + MP:0010468 + http://www.medterms.com + @@ -108600,9 +164431,27 @@ - + Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]. + BTO:0002976 + EFO:0002524 + EMAPA:17856 + FMA:3789 + GAID:470 + MA:0000474 + MESH:D001012 + NCIT:C32038 + SCTID:244231007 + Wikipedia:Abdominal_aorta + galen:AbdominalAorta abdominal aorta + + + + Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]. + BTO:0002976 + Wikipedia:Abdominal_aorta + @@ -108628,9 +164477,27 @@ - + The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery. + EFO:0002550 + EHDAA2:0000835 + EMAPA:17615 + FMA:3932 + GAID:476 + MA:0001922 + MESH:D016122 + NCIT:C32814 + SCTID:244244002 + Wikipedia:Brachiocephalic_artery + galen:BrachioCephalicArtery brachiocephalic artery + + + + The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery. + MGI:csmith + MP:0010663 + @@ -108656,9 +164523,27 @@ - + A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]. + CALOHA:TS-0116 + EHDAA2:0000217 + EHDAA:7331 + EMAPA:17855 + FMA:3939 + GAID:479 + MA:0001926 + MESH:D017536 + NCIT:C32352 + SCTID:362041005 + VHOG:0000272 + Wikipedia:Common_carotid_artery common carotid artery plus branches + + + + A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]. + Wikipedia:Common_carotid_artery + @@ -108696,9 +164581,30 @@ - + One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta. + AAO:0010232 + EHDAA2:0001933 + EHDAA:4357 + EMAPA:17617 + FMA:3951 + GAID:511 + MA:0002045 + MESH:D013348 + NCIT:C33643 + SCTID:265790007 + TAO:0005086 + Wikipedia:Subclavian_artery + XAO:0000365 + ZFA:0005086 subclavian artery + + + + One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta. + ISBN:0073040584 + https://orcid.org/0000-0002-6601-2165 + @@ -108730,9 +164636,21 @@ - + The subclavian artery that supplies the right pectoral appendage. + EHDAA2:0004514 + FMA:3953 + MA:0002047 + NCIT:C33490 + SCTID:244246000 + Wikipedia:Subclavian_artery right subclavian artery + + + + The subclavian artery that supplies the right pectoral appendage. + http://orcid.org/0000-0002-6601-2165 + @@ -108764,9 +164682,32 @@ - + A tube extending from the mouth to the anus. + AAO:0010023 + BILA:0000083 + BTO:0000511 + BTO:0000545 + EHDAA2:0000726 + EHDAA:518 + EMAPA:16247 + FMA:45615 + MA:0000917 + NCIT:C34082 + TAO:0000112 + TGMA:0001819 + VHOG:0000309 + WBbt:0005743 + ZFA:0000112 + galen:AlimentaryTract digestive tract + + + + A tube extending from the mouth to the anus. + Wikipedia:Talk:Human_gastrointestinal_tract + https://github.com/geneontology/go-ontology/issues/7549 + @@ -108780,9 +164721,23 @@ - + The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]. + EHDAA2:0001036 + EMAPA:16738 + FMA:45662 + MA:0000435 + SCTID:281488008 + VHOG:0000382 + Wikipedia:Lower_respiratory_tract lower respiratory tract + + + + The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]. + Wikipedia:Lower_respiratory_tract + http://orcid.org/0000-0002-6601-2165 + @@ -108814,9 +164769,20 @@ - + The subclavian artery that supplies the left pectoral appendage. + FMA:4694 + MA:0002046 + NCIT:C32972 + SCTID:244245001 + Wikipedia:Subclavian_artery left subclavian artery + + + + The subclavian artery that supplies the left pectoral appendage. + http://orcid.org/0000-0002-6601-2165 + @@ -108847,9 +164813,29 @@ - + A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart. + BTO:0002683 + EHDAA2:0001962 + EHDAA:8726 + EMAPA:18417 + FMA:4720 + GAID:549 + MA:0000481 + MESH:D014683 + NCIT:C12816 + SCTID:181368006 + VHOG:0001195 + Wikipedia:Superior_vena_cava + galen:SuperiorVenaCava anterior vena cava + + + + A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart. + Wikipedia:Superior_vena_cava + http://orcid.org/0000-0002-6601-2165 + @@ -108875,9 +164861,27 @@ - + One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]. + AAO:0010236 + EHDAA2:0000877 + EHDAA:5407 + EMAPA:17620 + FMA:4724 + MA:0002157 + NCIT:C32849 + RETIRED_EHDAA2:0000878 + SCTID:181372005 + Wikipedia:Internal_jugular_vein + XAO:0000382 + galen:InternalJugularVein internal jugular vein + + + + One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]. + Wikipedia:Internal_jugular_vein + @@ -108902,9 +164906,21 @@ - + The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]. + EMAPA:36284 + FMA:4749 + MA:0002088 + NCIT:C53031 + SCTID:198293000 + Wikipedia:Bronchial_veins bronchial vein + + + + The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]. + Wikipedia:Bronchial_veins + @@ -108920,9 +164936,22 @@ - + The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. + BTO:0000654 + EMAPA:35240 + FMA:49151 + MA:0001269 + NCIT:C32315 + SCTID:280862009 + Wikipedia:Ciliary_muscle ciliary muscle + + + + The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. + Wikipedia:Ciliary_muscle + @@ -108947,11 +164976,122 @@ + FMA:49154 + MA:0001287 + SCTID:280888007 + Wikipedia:Iris_muscle muscle of iris + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A sphincter muscle that is part of the iris. + BTO:0000656 + EMAPA:35788 + FMA:49157 + MA:0001289 + NCIT:C33586 + SCTID:280889004 + Wikipedia:Iris_sphincter_muscle + sphincter pupillae + + + + + A sphincter muscle that is part of the iris. + Wikipedia:Iris_sphincter_muscle + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]. + BTO:0001371 + EMAPA:35286 + FMA:49158 + MA:0001288 + NCIT:C32463 + SCTID:280890008 + Wikipedia:Iris_dilator_muscle + dilatator pupillae + + + + + A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]. + Wikipedia:Iris_dilator_muscle + + + + @@ -108977,9 +165117,21 @@ - + A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]. + EMAPA:19213 + FMA:49549 + MA:0001950 + NCIT:C32578 + SCTID:181328007 + Wikipedia:Facial_artery facial artery + + + + A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]. + Wikipedia:Facial_artery + @@ -109011,8 +165163,25 @@ + Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. + EV:0100146 + FMA:5022 + GAID:131 + MA:0000015 + SCTID:71616004 + TAO:0005145 + VHOG:0001245 + XAO:0000172 + ZFA:0005145 + galen:Muscle muscle organ + + + + Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. + GO:0007517 + @@ -109026,8 +165195,37 @@ + An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]. + AAO:0010211 + AEO:0000208 + BTO:0000573 + CALOHA:TS-0054 + EFO:0000814 + EHDAA2:0003253 + EMAPA:35147 + EV:0100026 + FMA:50720 + GAID:468 + MA:0000064 + MAT:0000034 + MESH:D001158 + MIAA:0000034 + NCIT:C12372 + SCTID:362877004 + TAO:0000005 + VHOG:0001251 + Wikipedia:Artery + XAO:0000114 + ZFA:0000005 + galen:Artery artery + + + + An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]. + AEO:JB + @@ -109058,8 +165256,130 @@ + Any of the tubular branching vessels that carry blood from the capillaries toward the heart. + AAO:0010212 + AEO:0000209 + BTO:0000234 + CALOHA:TS-1108 + EFO:0000816 + EHDAA2:0003254 + EMAPA:35906 + EV:0100031 + FMA:50723 + GAID:492 + MA:0000067 + MAT:0000037 + MESH:D014680 + MIAA:0000037 + NCIT:C12814 + SCTID:181367001 + TAO:0000082 + VHOG:0001743 + Wikipedia:Vein + XAO:0000115 + ZFA:0000082 + galen:Vein vein + + + + Any of the tubular branching vessels that carry blood from the capillaries toward the heart. + Wikipedia:Vein + + + + + + + + + + + + + + + + + + + + + + + + + + + A portal vein that transports nutrients from the digestive tract to the liver[Kardong]. + AAO:0010214 + FMA:50735 + MA:0002132 + TAO:0005090 + VHOG:0000642 + Wikipedia:Hepatic_portal_vein + ZFA:0005090 + hepatic portal vein + + + + + A portal vein that transports nutrients from the digestive tract to the liver[Kardong]. + ISBN:0073040584 + Wikipedia:Hepatic_portal_vein + http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The first major branch of the abdominal aorta. + EHDAA2:0004519 + EMAPA:35202 + FMA:50737 + GAID:483 + MA:0001931 + MESH:D002445 + NCIT:C52846 + SCTID:181340007 + Wikipedia:Celiac_artery + dorsal aorta in Kardong + celiac artery + + + + + The first major branch of the abdominal aorta. + Wikipedia:Celiac_artery + @@ -109120,9 +165440,40 @@ - + Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw). + AAO:0010470 + BAMS:5n + BAMS:Vn + BAMS:nV + BIRNLEX:869 + BM:VN + BTO:0001072 + EFO:0001402 + EHDAA2:0002084 + EHDAA:3738 + EMAPA:17576 + FMA:50866 + GAID:726 + MA:0001100 + MBA:901 + MESH:D014276 + MFMO:0000093 + NCIT:C12806 + SCTID:362459002 + TAO:0000697 + VHOG:0000704 + Wikipedia:Trigeminal_nerve + XAO:0003092 + ZFA:0000697 trigeminal nerve + + + + Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw). + ISBN:0471209627 + Wikipedia:Trigeminal_nerve + @@ -109153,9 +165504,21 @@ - + The pulmonary artery that supplies the right lung. + FMA:50872 + MA:0002500 + NCIT:C33489 + SCTID:244235003 + Wikipedia:Right_pulmonary_artery + galen:RightPulmonaryArtery right pulmonary artery + + + + The pulmonary artery that supplies the right lung. + UBERON:cjm + @@ -109186,9 +165549,21 @@ - + The pulmonary artery that supplies the left lung. + FMA:50873 + MA:0002032 + NCIT:C32971 + SCTID:244234004 + Wikipedia:Left_pulmonary_artery + galen:LeftPulmonaryArtery left pulmonary artery + + + + The pulmonary artery that supplies the left lung. + UBERON:cjm + @@ -109209,9 +165584,22 @@ - + The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]. + AAO:0010513 + EMAPA:19220 + FMA:50874 + MA:0002115 + NCIT:C32579 + SCTID:181374006 + Wikipedia:Facial_vein facial vein + + + + The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]. + Wikipedia:Facial_vein + @@ -109244,8 +165632,39 @@ + The cranial ganglion that is associated with and extends fibers into the trigeminal nerve. + AAO:0011107 + BAMS:5Gn + BAMS:GV + BTO:0001231 + EFO:0000903 + EHDAA2:0002085 + EHDAA:2113 + EMAPA:16797 + FMA:52618 + GAID:725 + MA:0001080 + MAT:0000511 + MESH:D012668 + NCIT:C62642 + SCTID:244449009 + TAO:0000295 + VHOG:0000694 + Wikipedia:Trigeminal_ganglion + XAO:0000427 + XAO:0000428 + ZFA:0000295 + neuronames:1402 trigeminal ganglion + + + + The cranial ganglion that is associated with and extends fibers into the trigeminal nerve. + http://orcid.org/0000-0002-6601-2165 + http://www.ncbi.nlm.nih.gov/books/NBK53171 + https://github.com/obophenotype/uberon/issues/693 + @@ -109290,9 +165709,194 @@ - + The bone at the lower, posterior part of the skull. + EMAPA:25112 + FMA:52735 + GAID:227 + MA:0001468 + MESH:D009777 + NCIT:C12757 + SCTID:181796003 + Wikipedia:Occipital_bone occipital bone + + + + The bone at the lower, posterior part of the skull. + ISBN:0-683-40008-8 + MP:0005269 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended. + CALOHA:TS-2343 + EMAPA:18340 + FMA:52736 + GAID:230 + MA:0001472 + MESH:D013100 + NCIT:C12790 + SCTID:272676008 + Wikipedia:Sphenoid_bone + sphenoid bone + + + + + An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended. + Wikipedia:Sphenoid_bone + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]. + BTO:0004140 + EMAPA:19018 + FMA:52740 + GAID:212 + MA:0001483 + MESH:D005004 + NCIT:C12711 + SCTID:272674006 + VHOG:0001317 + Wikipedia:Ethmoid_bone + ethmoid bone + + + + + A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]. + Wikipedia:Ethmoid_bone + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball. + BTO:0004687 + FMA:53074 + GAID:223 + MA:0002482 + MESH:D009915 + NCIT:C12347 + TAO:0001410 + Wikipedia:Orbit_(anatomy) + XAO:0003171 + ZFA:0001410 + galen:Orbit + orbit of skull + + + + + Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball. + TAO:0001410 + Wikipedia:Orbit_(anatomy) + http://orcid.org/0000-0002-6601-2165 + @@ -109324,9 +165928,25 @@ - + Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof. + FMA:53672 + MA:0000317 + SCTID:361731002 + TAO:0001580 + Wikipedia:Neuroranium + XAO:0003170 + ZFA:0001580 neurocranium + + + + Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof. + PMID:11523816 + TAO:MAH + Wikipedia:Neuroranium + ZFA:0001580 + @@ -109382,8 +166002,88 @@ + Subdivision of skeleton which includes upper and lower jaw skeletons. + AAO:0000988 + BTO:0001749 + EMAPA:35455 + FMA:54396 + GAID:214 + MA:0001905 + MESH:D007568 + NCIT:C48821 + SCTID:181811001 + TAO:0001227 + Wikipedia:Jaw + ZFA:0001227 + galen:Jaw jaw skeleton + + + + Subdivision of skeleton which includes upper and lower jaw skeletons. + Wikipedia:Jaw + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. + AAO:0000620 + EHDAA2:0002118 + EHDAA2:0004607 + EHDAA:8025 + EMAPA:17924 + FMA:59399 + SCTID:362636001 + VHOG:0000454 + Wikipedia:Upper_jaw + ncithesaurus:Upper_Jaw + See notes for jaw w.r.t skeletal element vs subdivision of head. + upper jaw region + + + + + Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. + Wikipedia:Upper_jaw + http://orcid.org/0000-0002-6601-2165 + @@ -109421,8 +166121,27 @@ + Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. + AAO:0000272 + EFO:0003660 + EHDAA2:0001018 + EHDAA:7995 + EMAPA:17906 + FMA:59398 + MESH:D008334 + SCTID:362637005 + VHOG:0000453 + Wikipedia:Lower_jaw + ncithesaurus:Lower_Jaw + See notes for jaw w.r.t skeletal element vs subdivision of head lower jaw region + + + + Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. + Wikipedia:Lower_jaw + @@ -109453,9 +166172,33 @@ - + The groups of nerve cell bodies associated with the twelve cranial nerves. + BIRNLEX:2597 + BTO:0000106 + EFO:0000902 + EMAPA:16659 + FMA:54502 + MA:0000213 + MA:0000214 + MAT:0000200 + MIAA:0000200 + SCTID:244448001 + TAO:0000013 + VHOG:0000076 + Wikipedia:Cranial_nerve_ganglion + XAO:0000027 + ZFA:0000013 cranial ganglion + + + + The groups of nerve cell bodies associated with the twelve cranial nerves. + ISBN:0-683-40008-8 + MGI:csmith + MP:0001081 + PMID:9362461 + @@ -109492,8 +166235,22 @@ + An anatomical space that is enclosed by a pharynx. + AAO:0010435 + BSA:0000113 + BTO:0002097 + EMAPA:18381 + FMA:54935 + SCTID:180543003 + XAO:0000105 cavity of pharynx + + + + An anatomical space that is enclosed by a pharynx. + OBOL:automatic + @@ -109513,8 +166270,28 @@ + The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens. + BTO:0002084 + EHDAA2:0000129 + EHDAA:9033 + EMAPA:18231 + FMA:58078 + GAID:889 + MA:0000262 + MESH:D000867 + NCIT:C12667 + SCTID:181160009 + VHOG:0001431 + Wikipedia:Anterior_chamber_of_eyeball anterior chamber of eyeball + + + + The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens. + MESH:A09.371.060.067 + MP:0005205 + @@ -109554,8 +166331,25 @@ + The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]. + CALOHA:TS-2228 + EMAPA:35901 + FMA:58103 + GAID:912 + MA:0002480 + MESH:D014602 + NCIT:C12811 + SCTID:280648000 + Wikipedia:Uvea uvea + + + + The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]. + MP:0005197 + Wikipedia:Uvea + @@ -109582,9 +166376,33 @@ - + The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye. + AAO:0010347 + BTO:0000653 + CALOHA:TS-0491 + EFO:0004245 + EMAPA:19154 + EV:0100345 + FMA:58235 + GAID:917 + MA:0000273 + MESH:D007498 + NCIT:C12737 + SCTID:181164000 + TAO:0001238 + VHOG:0000101 + Wikipedia:Iris_(anatomy) + XAO:0000185 + ZFA:0001238 iris + + + + The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye. + ISBN:0-683-40008-8 + MP:0001322 + @@ -109622,9 +166440,31 @@ - + The smooth stratified squamous epithelium that covers the outer surface of the cornea. + BTO:0000287 + CALOHA:TS-0173 + EFO:0001917 + EHDAA2:0000319 + EMAPA:17162 + FMA:58263 + GAID:895 + MA:0001243 + MESH:D019573 + NCIT:C12928 + SCTID:368825001 + TAO:0002187 + Wikipedia:Corneal_epithelium + ZFA:0001683 corneal epithelium + + + + The smooth stratified squamous epithelium that covers the outer surface of the cornea. + MESH:A09.371.060.217.325 + MGI:smb + MP:0006000 + @@ -109663,9 +166503,31 @@ - + Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]. + AAO:0010354 + BTO:0001606 + EMAPA:19027 + EV:0100342 + FMA:58269 + GAID:911 + MA:0000280 + MESH:D012590 + NCIT:C12784 + SCTID:181163006 + VHOG:0001274 + Wikipedia:Sclera + XAO:0000183 + ZFA:0005563 + Disease notes: implicated in rheumatoid arthritis. sclera + + + + Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]. + Wikipedia:Sclera + ZFIN:ZDB-PUB-050701-15 + @@ -109691,8 +166553,22 @@ + A skeletal muscle organ that is part of the trunk region. + AAO:0000611 + EMAPA:35888 + FMA:58274 + MA:0000514 + TAO:0000473 + XAO:0003230 + ZFA:0000473 skeletal muscle of trunk + + + + A skeletal muscle organ that is part of the trunk region. + http://orcid.org/0000-0002-6601-2165 + @@ -109731,9 +166607,32 @@ - + The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes. + AAO:0010341 + BTO:0000260 + CALOHA:TS-0694 + EMAPA:19065 + EV:0100346 + FMA:58295 + GAID:916 + MA:0000264 + MESH:D002924 + NCIT:C12345 + SCTID:263340007 + VHOG:0000102 + Wikipedia:Ciliary_body + XAO:0000186 + neuronames:1571 ciliary body + + + + The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes. + ISBN:0-683-40008-8 + MP:0005099 + Wikipedia:Ciliary_body + @@ -109783,9 +166682,29 @@ - + Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]. + BTO:0001829 + CALOHA:TS-2054 + EMAPA:19077 + EV:0100347 + FMA:58298 + GAID:913 + MA:0000263 + MESH:D002829 + NCIT:C12344 + SCTID:181172003 + TAO:0005229 + VHOG:0001568 + Wikipedia:Choroid + ZFA:0005229 optic choroid + + + + Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]. + Wikipedia:Choroid + @@ -109835,8 +166754,29 @@ + The lamellated connective tissue of the cornea between the Bowman and Descemet membranes. + CALOHA:TS-1138 + EFO:0002514 + EMAPA:17602 + FMA:58306 + GAID:893 + MA:0001245 + MESH:D003319 + NCIT:C12699 + SCTID:362511000 + TAO:0002189 + Wikipedia:Corneal_stroma + ZFA:0001685 substantia propria of cornea + + + + The lamellated connective tissue of the cornea between the Bowman and Descemet membranes. + ISBN:0-683-40008-8 + MESH:A09.371.060.217.228 + MP:0005300 + @@ -109874,9 +166814,23 @@ - + A double layer covering the ciliary body that produces aqueous humor. + BTO:0001770 + CALOHA:TS-0695 + EMAPA:35239 + FMA:58464 + MA:0001238 + NCIT:C32314 + SCTID:280870004 + Wikipedia:Ciliary_body#Ciliary_epithelium ciliary epithelium + + + + A double layer covering the ciliary body that produces aqueous humor. + Wikipedia:Ciliary_body#Ciliary_epithelium + @@ -109908,8 +166862,22 @@ + The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae. + EMAPA:35451 + FMA:58526 + MA:0002777 + SCTID:280882008 + Wikipedia:Iris_stroma + ZFA:0005569 iris stroma + + + + The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae. + Wikipedia:Iris_stroma + http://www.drugs.com/dict/stroma-of-iris.html + @@ -109934,9 +166902,31 @@ - + The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]. + AAO:0011101 + BAMS:spin + BTO:0000870 + EHDAA2:0001898 + EMAPA:16989 + FMA:5858 + GAID:841 + MA:0000233 + MESH:D013127 + NCIT:C12792 + SCTID:361099009 + VHOG:0000824 + Wikipedia:Spinal_nerve + XAO:0003101 + neuronames:1228 spinal nerve + + + + The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]. + MESH:A08.800.800.720 + MP:0001077 + @@ -109957,8 +166947,22 @@ + Any of the layers that make up the retina[MP]. + AAO:0010353 + EMAPA:35742 + FMA:58617 + MA:0001319 + NCIT:C49328 + SCTID:280657006 + XAO:0000266 layer of retina + + + + Any of the layers that make up the retina[MP]. + MP:0003727 + @@ -109994,9 +166998,35 @@ - + Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord. + AAO:0000108 + BAMS:cran + BIRNLEX:1623 + BTO:0001104 + EHDAA2:0000323 + EMAPA:17264 + FMA:5865 + GAID:802 + MA:0000215 + MBA:967 + MESH:D003391 + NCIT:C12700 + SCTID:244447006 + TAO:0000641 + VHOG:0000279 + Wikipedia:Cranial_nerve + XAO:0000429 + XAO:0003089 + ZFA:0000641 + neuronames:1227 cranial nerve + + + + Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord. + Wikipedia:Cranial_nerve + @@ -110017,8 +167047,28 @@ + A thick watery refractive medium that fills the space between the lens and the cornea[WP]. + EHDAA2:0000139 + EHDAA:10196 + EMAPA:18232 + ENVO:02000024 + FMA:58819 + GAID:890 + MA:0001236 + MESH:D001082 + NCIT:C13190 + SCTID:280587006 + VHOG:0000548 + Wikipedia:Aqueous_humor + ZFA:0005564 aqueous humor of eyeball + + + + A thick watery refractive medium that fills the space between the lens and the cornea[WP]. + Wikipedia:Aqueous_humor + @@ -110043,9 +167093,22 @@ - + The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells. + AEO:0001000 + BTO:0005630 + EMAPA:36596 + FMA:5885 + MA:0002566 + MESH:D017950 + NCIT:C13060 sensory ganglion + + + + The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells. + MP:0000960 + @@ -110072,8 +167135,25 @@ + Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive). + EMAPA:36594 + FMA:58865 + MA:0002484 + MESH:D000869 + NCIT:C12668 + SCTID:280658001 + Wikipedia:Anterior_segment_of_eyeball + ZFA:0005566 anterior segment of eyeball + + + + Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive). + ISBN:0-683-40008-8 + MESH:A09.371.060 + MP:0005193 + @@ -110100,8 +167180,23 @@ + Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive). + EMAPA:36595 + FMA:58868 + MA:0002485 + NCIT:C12906 + SCTID:280659009 + Wikipedia:Posterior_segment_of_eyeball + ZFA:0005567 posterior segment of eyeball + + + + Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive). + ISBN:0-683-40008-8 + MP:0005195 + @@ -110133,9 +167228,25 @@ - + A layer of epithelial cells that is part of the eye. + BTO:0001873 + CALOHA:TS-0543 + EMAPA:32871 + FMA:58871 + MA:0001301 + SCTID:362523006 + TAO:0001326 + Wikipedia:Lens_(anatomy)#Lens_Epithelium + XAO:0004094 + ZFA:0001326 epithelium of lens + + + + A layer of epithelial cells that is part of the eye. + http://orcid.org/0000-0002-6601-2165 + @@ -110185,8 +167296,26 @@ + The elastic, clear, membrane-like structure, that is outer most layer of the lens. + EHDAA2:0000977 + EMAPA:18237 + FMA:58881 + MA:0001300 + NCIT:C32975 + SCTID:244500004 + VHOG:0000550 + Wikipedia:Lens_(anatomy)#Lens_capsule + ZFA:0005574 capsule of lens + + + + The elastic, clear, membrane-like structure, that is outer most layer of the lens. + MGI:smb + MP:0003236 + PMID:15483628 + @@ -110217,9 +167346,23 @@ - + Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion. + AEO:0001001 + CALOHA:TS-2340 + EMAPA:18221 + FMA:5889 + MA:0000220 + MESH:D005725 + NCIT:C12720 + Wikipedia:Autonomic_ganglion autonomic ganglion + + + + Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion. + Wikipedia:Autonomic_ganglion + @@ -110263,8 +167406,26 @@ + A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia. + AAO:0010773 + BTO:0001333 + CALOHA:TS-0994 + EHDAA2:0001969 + EMAPA:17157 + FMA:5890 + MA:0000226 + NCIT:C12467 + SCTID:362485003 + Wikipedia:Sympathetic_ganglion sympathetic ganglion + + + + A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia. + MP:0001008 + http://orcid.org/0000-0002-6601-2165 + @@ -110290,8 +167451,78 @@ + One of the two fleshy folds which surround the opening of the mouth. + BTO:0001647 + CALOHA:TS-0558 + EMAPA:32839 + FMA:59816 + GAID:76 + MA:0000343 + MESH:D008046 + NCIT:C12220 + SCTID:181221003 + TAO:0007006 + VHOG:0000677 + Wikipedia:Lip + ZFA:0007006 + galen:Lip lip + + + + One of the two fleshy folds which surround the opening of the mouth. + Wikipedia:Lip + http://www.medterms.com/script/main/art.asp?articlekey=9458 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Lip that covers the upper portion of the mouth.[TAO]. + EMAPA:17925 + FMA:59817 + MA:0000919 + SCTID:245776003 + TAO:0001970 + VHOG:0001750 + Wikipedia:Upper_lip + ZFA:0005226 + upper lip + + + + + Lip that covers the upper portion of the mouth.[TAO]. + TAO:0001970 + Wikipedia:Upper_lip + @@ -110322,8 +167553,24 @@ + Lip that covers the lower portion of the mouth.[TAO]. + EMAPA:17909 + FMA:59818 + MA:0000921 + NCIT:C94572 + SCTID:245777007 + TAO:0002060 + Wikipedia:Lower_lip + ZFA:0005225 lower lip + + + + Lip that covers the lower portion of the mouth.[TAO]. + TAO:0002060 + Wikipedia:Lower_lip + @@ -110354,9 +167601,27 @@ - + A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. + BAMS:phn + BTO:0001063 + EHDAA:4677 + EMAPA:17813 + FMA:6191 + GAID:848 + MA:0001170 + MESH:D010791 + NCIT:C52813 + SCTID:280344009 + VHOG:0000728 + Wikipedia:Phrenic_nerve phrenic nerve + + + + A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. + VHOG:0000728 + @@ -110383,9 +167648,43 @@ - + The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. + AAO:0010149 + BAMS:MES + BIRNLEX:1667 + BM:MB + BTO:0000138 + CALOHA:TS-0630 + DHBA:10648 + DMBA:16649 + EFO:0000919 + EHDAA2:0001162 + EHDAA:3694 + EMAPA:16974 + EV:0100242 + FMA:61993 + HBA:9001 + MA:0000207 + MAT:0000106 + MBA:313 + MESH:D008636 + MIAA:0000106 + NCIT:C12510 + RETIRED_EHDAA2:0001104 + SCTID:279099009 + TAO:0000128 + VHOG:0000069 + Wikipedia:Midbrain + XAO:0000014 + ZFA:0000128 midbrain + + + + The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. + GO:0030901 + @@ -110410,8 +167709,28 @@ + A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]. + DHBA:12664 + EFO:0003617 + EMAPA:16148 + FMA:295666 + MAT:0000272 + MIAA:0000272 + RETIRED_EHDAA2:0000669 + TAO:0001064 + VHOG:0000672 + Wikipedia:Rhombomere + XAO:0004079 + ZFA:0001064 rhombomere + + + + A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]. + Wikipedia:Rhombomere + ZFIN:curator + @@ -110431,8 +167750,33 @@ + Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]. + BAMS:Met + BIRNLEX:965 + BTO:0000673 + CALOHA:TS-2029 + DHBA:10655 + EHDAA2:0001149 + EHDAA:5498 + EMAPA:17071 + FMA:62003 + GAID:594 + HBA:4833 + MA:0000197 + MESH:D020540 + NCIT:C32741 + VHOG:0000741 + Wikipedia:Metencephalon + the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]. metencephalon + + + + Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]. + Wikipedia:Metencephalon + https://github.com/obophenotype/uberon/issues/300 + @@ -110471,9 +167815,45 @@ - + Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. + AAO:0010486 + BAMS:MY + BAMS:Md + BIRNLEX:957 + BM:Me + BTO:0000041 + CALOHA:TS-0607 + DMBA:17352 + EFO:0000924 + EHDAA2:0001088 + EHDAA:7588 + EMAPA:17550 + EV:0100275 + FMA:62004 + GAID:590 + MA:0000206 + MAT:0000111 + MAT:0000367 + MBA:354 + MESH:D008526 + MIAA:0000111 + NCIT:C12442 + SCTID:279104005 + TAO:0000545 + VHOG:0000181 + Wikipedia:Bone_marrow_of_ovary_oblongata + XAO:0003100 + ZFA:0000545 medulla oblongata + + + + Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. + FMA:62004 + GO:0021550 + Wikipedia:Bone_marrow_of_ovary_oblongata + @@ -110510,9 +167890,74 @@ - + The epithelial lining of the trachea which contains numerous ciliated cells. + BTO:0001389 + CALOHA:TS-1061 + EHDAA2:0002069 + EHDAA:5007 + EMAPA:16855 + EMAPA:18409 + FMA:62015 + MA:0001862 + NCIT:C33797 + VHOG:0001045 epithelium of trachea + + + + The epithelial lining of the trachea which contains numerous ciliated cells. + ISBN:0-397-51047-0 + MGI:cwg + MP:0002285 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a small intestine [Automatically generated definition]. + BTO:0001258 + CALOHA:TS-2104 + EMAPA:35778 + FMA:62017 + MA:0001553 + SCTID:45480009 + TAO:0005127 + ZFA:0005127 + epithelium of small intestine + + + + + An epithelium that is part of a small intestine [Automatically generated definition]. + OBOL:automatic + @@ -110537,8 +167982,21 @@ + An endothelium that is part of a capillary [Automatically generated definition]. + BTO:0004954 + CALOHA:TS-0112 + EMAPA:36292 + FMA:62114 + MA:0000711 + NCIT:C49215 endothelium of capillary + + + + An endothelium that is part of a capillary [Automatically generated definition]. + OBOL:automatic + @@ -110564,8 +168022,19 @@ + An endothelium that is part of an arteriole [Automatically generated definition]. + EMAPA:36286 + FMA:62115 + MA:0000705 + NCIT:C49192 endothelium of arteriole + + + + An endothelium that is part of an arteriole [Automatically generated definition]. + OBOL:automatic + @@ -110592,8 +168061,23 @@ + An endothelium that is part of an artery [Automatically generated definition]. + AAO:0011013 + BTO:0004757 + EMAPA:35148 + FMA:62116 + MA:0000707 + NCIT:C49194 + VHOG:0001215 + XAO:0000357 endothelium of artery + + + + An endothelium that is part of an artery [Automatically generated definition]. + OBOL:automatic + @@ -110619,8 +168103,19 @@ + An endothelium that is part of a venule [Automatically generated definition]. + EMAPA:36290 + FMA:62117 + MA:0000716 + NCIT:C49319 endothelium of venule + + + + An endothelium that is part of a venule [Automatically generated definition]. + OBOL:automatic + @@ -110646,8 +168141,23 @@ + An endothelium that is part of a vein [Automatically generated definition]. + AAO:0011110 + BTO:0004756 + EMAPA:36288 + FMA:62118 + MA:0000712 + NCIT:C49317 + VHOG:0001216 + XAO:0000358 endothelium of vein + + + + An endothelium that is part of a vein [Automatically generated definition]. + OBOL:automatic + @@ -110673,9 +168183,35 @@ - + Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. + BAMS:MTg + BIRNLEX:1200 + BTO:0003388 + DHBA:12195 + EFO:0000921 + EHDAA2:0004475 + EMAPA:18215 + FMA:62393 + HBA:9002 + MA:0000212 + MAT:0000452 + SCTID:362392007 + TAO:0000160 + VHOG:0001367 + Wikipedia:Midbrain_tegmentum + XAO:0004271 + ZFA:0000160 + 'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum midbrain tegmentum + + + + Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. + FMA:FMA + ISBN:0471888893 + Wikipedia:Midbrain_tegmentum + @@ -110701,8 +168237,18 @@ + A multi-tissue structure that is part of a spinal cord. + BIRNLEX:1496 + NCIT:C33969 + SCTID:244437008 regional part of spinal cord + + + + A multi-tissue structure that is part of a spinal cord. + OBOL:automatic + @@ -110727,9 +168273,19 @@ - + An epithelium that is part of a respiratory bronchiole [Automatically generated definition]. + EMAPA:35730 + FMA:62498 + MA:0001773 + NCIT:C48943 epithelium of respiratory bronchiole + + + + An epithelium that is part of a respiratory bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -110772,9 +168328,20 @@ - + The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]. + EMAPA:35192 + FMA:62649 + MA:0001835 + NCIT:C49209 + SCTID:278980009 cartilage of bronchus + + + + The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]. + MP:0010988 + @@ -110800,8 +168367,20 @@ + A submucosa that is part of a bronchus [Automatically generated definition]. + BTO:0002108 + FMA:62653 + MA:0001837 + NCIT:C49214 + SCTID:85546005 submucosa of bronchus + + + + A submucosa that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -110826,9 +168405,19 @@ - + An epithelium that lines a terminal bronchiole. + EMAPA:36283 + FMA:62794 + MA:0001774 + NCIT:C33755 terminal bronchiole epithelium + + + + An epithelium that lines a terminal bronchiole. + http://orcid.org/0000-0002-6601-2165 + @@ -110877,8 +168466,103 @@ + The liquid component of blood, in which erythrocytes are suspended. + BTO:0000131 + CALOHA:TS-0800 + EFO:0001905 + EMAPA:35690 + FMA:62970 + GAID:1178 + MA:0002501 + MAT:0000052 + MESH:D010949 + MIAA:0000052 + NCIT:C13356 + Wikipedia:Blood_plasma blood plasma + + + + The liquid component of blood, in which erythrocytes are suspended. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium. + BTO:0000121 + CALOHA:TS-1172 + ENVO:02000023 + FMA:62971 + GAID:1157 + MA:0002513 + MESH:D001646 + NCIT:C13192 + Wikipedia:Bile + ZFA:0005857 + galen:Bile + bile + + + + + Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium. + DOI:10.1002/cphy.c120027 + Wikipedia:Bile + @@ -110903,6 +168587,14 @@ + BTO:0000501 + FMA:62972 + GAID:1160 + MA:0002519 + MESH:D005750 + NCIT:C32661 + Wikipedia:Gastric_juice + galen:GastricJuice gastric juice @@ -110929,8 +168621,20 @@ + A submucosa that is part of a esophagus [Automatically generated definition]. + BTO:0002109 + EMAPA:35325 + FMA:62997 + MA:0002724 + SCTID:362128009 submucosa of esophagus + + + + A submucosa that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -110955,8 +168659,19 @@ + A lamina propria that is part of a esophagus [Automatically generated definition]. + EMAPA:26987 + FMA:63050 + MA:0001568 + NCIT:C49223 lamina propria of esophagus + + + + A lamina propria that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -110981,8 +168696,18 @@ + A serous membrane that is part of a esophagus [Automatically generated definition]. + EMAPA:35322 + FMA:63057 + MA:0001571 serosa of esophagus + + + + A serous membrane that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -111014,8 +168739,57 @@ + The epithelial layer that lines the luminal space of the esophagus. + BTO:0001578 + CALOHA:TS-0698 + EFO:0003041 + EHDAA2:0001287 + EMAPA:16835 + FMA:63063 + MA:0001565 + NCIT:C49221 + TAO:0001499 + ZFA:0001499 epithelium of esophagus + + + + The epithelial layer that lines the luminal space of the esophagus. + ISBN:0-683-40008-8 + MP:0000468 + + + + + + + + + + + + + + + + + + + + + + + + + + EMAPA:32925 + FMA:63120 + MA:0000724 + SCTID:371401008 + VHOG:0001430 + parenchyma of pancreas + @@ -111036,9 +168810,27 @@ - + One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins. + BTO:0002626 + EMAPA:35917 + FMA:63130 + MA:0000071 + MESH:D014699 + NCIT:C12818 + SCTID:341687009 + TAO:0005315 + VHOG:0001765 + Wikipedia:Venule + ZFA:0005315 venule + + + + One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins. + MESH:A07.231.432.952 + MP:0004125 + @@ -111080,8 +168872,27 @@ + The smallest division of the artery located between the muscular arteries and the capillaries[GO]. + AAO:0010253 + BTO:0001997 + EMAPA:35146 + FMA:63182 + MA:0000063 + MESH:D001160 + NCIT:C12672 + SCTID:337724002 + TAO:0002138 + VHOG:0001763 + Wikipedia:Arteriole + ZFA:0005255 arteriole + + + + The smallest division of the artery located between the muscular arteries and the capillaries[GO]. + GO:0014830 + @@ -111138,9 +168949,39 @@ - + A vessel through which blood circulates in the body. + AAO:0011004 + AEO:0000207 + BTO:0001102 + CALOHA:TS-0080 + EFO:0000817 + EHDAA2:0003252 + EHDAA:240 + EMAPA:32743 + EMAPA:35993 + FMA:50722 + FMA:63183 + GAID:169 + MA:0000060 + MAT:0000393 + MESH:D001808 + NCIT:C12679 + NLXANAT:090901 + SCTID:361097006 + TAO:0002137 + VHOG:0001250 + Wikipedia:Blood_vessel + XAO:0001011 + ZFA:0005314 blood vessel + + + + A vessel through which blood circulates in the body. + BTO:0001102 + Wikipedia:Blood_vessel + @@ -111175,9 +169016,33 @@ - + Any of the smallest blood vessels connecting arterioles with venules. + AAO:0010252 + BTO:0002045 + CALOHA:TS-2006 + EFO:0001906 + EMAPA:35198 + EV:0100035 + FMA:63194 + MA:0000065 + MESH:D002196 + NCIT:C12685 + NLXANAT:090902 + TAO:0005250 + VHOG:0001253 + Wikipedia:Capillary + XAO:0000116 + ZFA:0005250 capillary + + + + Any of the smallest blood vessels connecting arterioles with venules. + ISBN:0073040584 + Wikipedia:Capillary + https://github.com/obophenotype/uberon/issues/137 + @@ -111216,9 +169081,26 @@ - + A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]. + CALOHA:TS-0172 + EMAPA:35935 + FMA:63882 + GAID:891 + MA:0001242 + MESH:D004728 + NCIT:C12707 + SCTID:368827009 + TAO:0002186 + Wikipedia:Corneal_endothelium + ZFA:0001687 corneal endothelium + + + + A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]. + Wikipedia:Corneal_endothelium + @@ -111250,9 +169132,73 @@ - + A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]. + BTO:0000393 + CALOHA:TS-0278 + EFO:0002548 + FMA:63916 + GAID:520 + MESH:D004727 + NCIT:C12481 + SCTID:27168002 + galen:Endothelium + The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980) endothelium + + + + A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]. + FMA:63916 + MESH:A10.272.491 + https://github.com/obophenotype/uberon/issues/225 + + + + + + + + + + + + + + + + + + + + + + + + + + Portion of semisolid bodily waste discharged through the anus[MW,modified]. + BTO:0000440 + CALOHA:TS-2345 + ENVO:00002003 + FMA:64183 + GAID:1199 + MA:0002509 + MAT:0000053 + MESH:D005243 + MIAA:0000053 + NCIT:C13234 + Wikipedia:Feces + galen:Feces + feces + + + + + Portion of semisolid bodily waste discharged through the anus[MW,modified]. + Wikipedia:Feces + http://www.merriam-webster.com/dictionary/feces + @@ -111266,8 +169212,26 @@ + Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance. + EMAPA:35414 + FMA:64783 + MA:0000109 + NCIT:C32746 + SCTID:39298000 + VSAO:0000094 + Wikipedia:Hyaline_cartilage + XAO:0004029 hyaline cartilage tissue + + + + Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000094 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -111328,9 +169292,33 @@ - + An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.. + AAO:0010221 + BTO:0000778 + CALOHA:TS-0839 + EFO:0001399 + EHDAA2:0001575 + EHDAA:4351 + EMAPA:17008 + FMA:66326 + GAID:505 + MA:0002031 + MESH:D011651 + NCIT:C12774 + SCTID:181380003 + VHOG:0000982 + Wikipedia:Pulmonary_artery + XAO:0004162 + galen:PulmonaryArtery pulmonary artery + + + + An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.. + Wikipedia:Pulmonary_artery + http://orcid.org/0000-0002-6601-2165 + @@ -111374,9 +169362,67 @@ - + Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]. + AAO:0010521 + BTO:0001799 + CALOHA:TS-0840 + EHDAA2:0001579 + EHDAA:2629 + EMAPA:18645 + FMA:66643 + GAID:543 + MA:0002206 + MESH:D011667 + NCIT:C12776 + SCTID:430160002 + VHOG:0001133 + Wikipedia:Pulmonary_vein + XAO:0000394 + galen:PulmonaryVein pulmonary vein + + + + Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]. + GO:0060577 + + + + + + + + + + + + + + + A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]. + BTO:0001792 + CALOHA:TS-0814 + EHDAA2:0001485 + EHDAA:6510 + EMAPA:17349 + FMA:66645 + GAID:540 + MA:0002198 + MESH:D011169 + NCIT:C33343 + SCTID:362064007 + VHOG:0000656 + XAO:0000392 + galen:PortalVein + portal vein + + + + + A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]. + BTO:0001792 + @@ -111390,8 +169436,28 @@ + A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. + AEO:0001012 + EHDAA2:0003136 + EHDAA2_RETIRED:0004658 + FMA:67242 + HBA:4006 + MA:0001112 + NCIT:C32695 + TAO:0002197 + VHOG:0001768 + Wikipedia:Gray_matter + ZFA:0001681 + neuronames:2869 gray matter + + + + A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. + Wikipedia:Gray_matter + http://orcid.org/0000-0002-6601-2165 + @@ -111423,9 +169489,89 @@ - + The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. + AAO:0010150 + BAMS:HB + BIRNLEX:942 + BTO:0000672 + CALOHA:TS-0457 + DHBA:10653 + DMBA:16808 + EFO:0000923 + EHDAA2:0000746 + EHDAA:3514 + EHDAA:6487 + EMAPA:16916 + FMA:67687 + MA:0000195 + MAT:0000107 + MBA:1065 + MESH:D012249 + MIAA:0000107 + NCIT:C40336 + SCTID:303456008 + TAO:0000029 + VHOG:0000070 + Wikipedia:Rhombencephalon + XAO:0000015 + ZFA:0000029 hindbrain + + + + The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. + Wikipedia:Rhombencephalon + ZFA:0000029 + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The simple columnar epithelial lining of the gall bladder. + BTO:0001449 + CALOHA:TS-1304 + EMAPA:35370 + FMA:67711 + MA:0001632 + NCIT:C49227 + epithelium of gall bladder + + + + + The simple columnar epithelial lining of the gall bladder. + MP:0009492 + @@ -111462,8 +169608,22 @@ + An epithelium that is part of a bronchus [Automatically generated definition]. + BTO:0001845 + CALOHA:TS-1240 + EFO:0000307 + EMAPA:32691 + FMA:67782 + MA:0001839 + NCIT:C32231 epithelium of bronchus + + + + An epithelium that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -111488,8 +169648,28 @@ + Muscle tissue that contains fibers that are divided by transverse bands into striations. + AAO:0010762 + AEO:0000140 + CALOHA:TS-2047 + EHDAA2:0003140 + EMAPA:36390 + FMA:67905 + MA:0002438 + NCIT:C12436 + WBbt:0005779 + Wikipedia:Striated_muscle + galen:StriatedMuscle striated muscle tissue + + + + Muscle tissue that contains fibers that are divided by transverse bands into striations. + CL:0000737 + GOC:dph + GOC:mtg_muscle + @@ -111530,9 +169710,25 @@ - + A systemic artery that supplies the lung with with oxygenated blood. + EMAPA:18608 + FMA:68109 + GAID:477 + MA:0001923 + MESH:D001981 + NCIT:C32230 + SCTID:244247009 + Wikipedia:Bronchial_artery + Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung. bronchial artery + + + + A systemic artery that supplies the lung with with oxygenated blood. + UBERON:cjm + Wikipedia:Bronchial_artery + @@ -111553,8 +169749,26 @@ + The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]. + BAMS:PnR + BAMS:RA-PONS + BAMS:RPn + BIRNLEX:1110 + DHBA:12471 + DHBA:12475 + FMA:68875 + HBA:9159 + MA:0001022 + MBA:238 + Wikipedia:Pontine_raphe_nucleus pontine raphe nucleus + + + + The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]. + Wikipedia:Pontine_raphe_nucleus + @@ -111595,9 +169809,37 @@ - + Respiration organ that develops as an outpocketing of the esophagus. + AAO:0000275 + AAO:0010567 + BTO:0000763 + CALOHA:TS-0568 + EFO:0000934 + EHDAA2:0001042 + EHDAA:1554 + EHDAA:2205 + EMAPA:16728 + EV:0100042 + FMA:7195 + GAID:345 + MA:0000415 + MAT:0000135 + MESH:D008168 + MIAA:0000135 + NCIT:C12468 + SCTID:181216001 + Wikipedia:Lung + XAO:0000119 + galen:Lung + Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP] lung + + + + Respiration organ that develops as an outpocketing of the esophagus. + http://orcid.org/0000-0002-6601-2165 + @@ -111623,9 +169865,19 @@ - + An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. + BTO:0003718 + FMA:69050 + TAO:0005249 + ZFA:0005249 vasculature + + + + An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. + ZFA:0005249 + @@ -111650,8 +169902,31 @@ + Anatomical structure that is part of an embryo. + AAO:0000138 + BILA:0000034 + BTO:0000174 + CALOHA:TS-2110 + EFO:0000461 + FMA:69067 + GAID:407 + MESH:D004628 + NCIT:C13229 + RETIRED_EHDAA2:0003169 + SCTID:667009 + TAO:0001105 + VSAO:0000178 + XAO:0003042 + ZFA:0001105 embryonic structure + + + + Anatomical structure that is part of an embryo. + BTO:0000174 + ZFIN:curator + @@ -111702,9 +169977,21 @@ - + An epithelium that is part of a bronchiole [Automatically generated definition]. + BTO:0001866 + CALOHA:TS-0570 + EMAPA:32693 + FMA:69077 + MA:0001772 + NCIT:C48942 epithelium of bronchiole + + + + An epithelium that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -111729,8 +170016,18 @@ + An artery that supplies the diaphragm. + FMA:69330 + MA:0002019 + NCIT:C33320 phrenic artery + + + + An artery that supplies the diaphragm. + https://orcid.org/0000-0002-6601-2165 + @@ -111758,8 +170055,24 @@ + The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles. + EHDAA2:0004143 + EMAPA:35887 + FMA:70301 + GAID:554 + MA:0000103 + MESH:D014338 + NCIT:C34317 + SCTID:308828009 + Wikipedia:Truncus_arteriosus_(embryology) truncus arteriosus + + + + The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles. + Wikipedia:Truncus_arteriosus_(embryology) + @@ -111776,8 +170089,29 @@ + The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]. + EHDAA2:0000434 + EHDAA2:0004028 + EHDAA:2586 + EMAPA:16696 + FMA:70302 + MA:0000078 + TAO:0001317 + VHOG:0000932 + Wikipedia:Atrioventricular_cushions + XAO:0004189 + ZFA:0001317 + GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form endocardial cushion + + + + The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]. + GO:0003197 + Wikipedia:Atrioventricular_cushions + ZFIN:curator + @@ -111797,8 +170131,27 @@ + The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart. + AAO:0010505 + EHDAA2:0001839 + EHDAA:480 + EMAPA:16237 + FMA:70303 + NCIT:C34299 + NCIT:C34300 + TAO:0000154 + VHOG:0000177 + Wikipedia:Sinus_venosus + ZFA:0000154 sinus venosus + + + + The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart. + PMID:20735616 + Wikipedia:Sinus_venosus + @@ -111850,9 +170203,35 @@ - + The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. + AAO:0000128 + BTO:0000294 + CALOHA:TS-2076 + EFO:0000953 + EMAPA:17527 + EV:0100154 + FMA:70323 + GAID:1321 + MA:0000152 + MAT:0000153 + MESH:D020405 + MIAA:0000153 + NCIT:C12701 + SCTID:361696001 + TAO:0001119 + VHOG:0000108 + Wikipedia:Dermis + XAO:0000217 + ZFA:0001119 dermis + + + + The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. + Wikipedia:Dermis + ZFIN:curator + @@ -111891,9 +170270,22 @@ - + Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. + BTO:0001314 + CALOHA:TS-2366 + FMA:70544 + NCIT:C33645 + TAO:0001136 + Wikipedia:Hypodermis + ZFA:0001136 hypodermis + + + + Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. + Wikipedia:Hypodermis + @@ -111918,8 +170310,29 @@ + An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen. + AAO:0010386 + BTO:0001491 + EHDAA:512 + EMAPA:16245 + FMA:7085 + MA:0000019 + MESH:D014781 + NCIT:C28287 + RETIRED_EHDAA2:0002201 + SCTID:118760003 + Wikipedia:Viscus + XAO:0003034 viscus + + + + An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen. + BTO:0001491 + Wikipedia:Viscus + https://github.com/obophenotype/mouse-anatomy-ontology/issues/14 + @@ -111945,9 +170358,28 @@ - + A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. + AAO:0010248 + BTO:0001703 + EHDAA2:0000290 + EMAPA:17321 + FMA:7096 + MA:0000075 + NCIT:C12868 + SCTID:244383003 + VHOG:0000328 + Wikipedia:Right_atrium + XAO:0003192 + galen:RightAtrium right cardiac atrium + + + + A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. + Wikipedia:Right_atrium + http://orcid.org/0000-0002-6601-2165 + @@ -111973,9 +170405,28 @@ - + A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve. + AAO:0010247 + BTO:0001702 + EHDAA2:0000275 + EMAPA:17315 + FMA:7097 + MA:0000074 + NCIT:C12869 + SCTID:244387002 + VHOG:0000369 + Wikipedia:Left_atrium + XAO:0003191 + galen:LeftAtrium left cardiac atrium + + + + A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve. + Wikipedia:Left_atrium + http://orcid.org/0000-0002-6601-2165 + @@ -112013,9 +170464,26 @@ - + A cardiac ventricle that is in the right side of the heart. + BTO:0001630 + CALOHA:TS-0443 + EHDAA2:0000196 + EMAPA:17340 + FMA:7098 + MA:0000093 + NCIT:C12870 + SCTID:244384009 + VHOG:0000717 + Wikipedia:Right_ventricle + galen:RightVentricle heart right ventricle + + + + A cardiac ventricle that is in the right side of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -112035,8 +170503,36 @@ + Cardiac chamber in which blood enters the heart. + AAO:0010246 + BTO:0000903 + CALOHA:TS-0437 + EFO:0000277 + EHDAA2:0000154 + EHDAA:1265 + EMAPA:16688 + EV:0100019 + FMA:7099 + GAID:555 + MA:0000073 + MAT:0000496 + MESH:D006325 + NCIT:C12728 + SCTID:261405004 + TAO:0000471 + VHOG:0000175 + Wikipedia:Heart_atrium + ZFA:0000471 + galen:Atrium cardiac atrium + + + + Cardiac chamber in which blood enters the heart. + Wikipedia:Heart_atrium + http://orcid.org/0000-0002-6601-2165 + @@ -112056,8 +170552,37 @@ + Cardiac chamber through which blood leaves the heart. + AAO:0010249 + BTO:0000862 + CALOHA:TS-0444 + EFO:0000317 + EHDAA2:0004164 + EHDAA:1912 + EMAPA:17331 + EV:0100020 + FMA:7100 + GAID:568 + MA:0000091 + MAT:0000497 + MESH:D006352 + NCIT:C12730 + SCTID:277699000 + TAO:0000009 + VHOG:0000435 + Wikipedia:Ventricle_(heart) + XAO:0003193 + ZFA:0000009 + galen:Ventricle cardiac ventricle + + + + Cardiac chamber through which blood leaves the heart. + Wikipedia:Ventricle_(heart) + http://orcid.org/0000-0002-6601-2165 + @@ -112095,9 +170620,26 @@ - + A cardiac ventricle that is in the left side of the heart. + BTO:0001629 + CALOHA:TS-0439 + EHDAA2:0002178 + EMAPA:17337 + FMA:7101 + MA:0000092 + NCIT:C12871 + SCTID:244385005 + VHOG:0000718 + Wikipedia:Left_ventricle + galen:LeftVentricle heart left ventricle + + + + A cardiac ventricle that is in the left side of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -112132,8 +170674,25 @@ + A cardiac septum that divides the left and right atria of the heart. + EHDAA2:0000838 + EHDAA:1896 + EMAPA:17011 + FMA:7108 + MA:0000084 + NCIT:C32818 + SCTID:362016003 + VHOG:0000385 + Wikipedia:Interatrial_septum + galen:InteratrialSeptum interatrial septum + + + + A cardiac septum that divides the left and right atria of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -112159,8 +170718,31 @@ + The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. + AAO:0000034 + EFO:0000942 + EHDAA2:0000161 + EHDAA:5049 + FMA:71221 + MA:0002986 + MAT:0000148 + MIAA:0000148 + TAO:0000317 + VHOG:0000317 + VSAO:0000093 + XAO:0003073 + ZFA:0000317 + previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed. postcranial axial skeleton + + + + The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. + ZFA:0000317 + https://sourceforge.net/tracker/?func=detail&aid=2983975&group_id=76834&atid=974957 + https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=2983977&group_id=76834 + @@ -112192,9 +170774,29 @@ - + Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]. + AAO:0000747 + EFO:0000951 + EMAPA:32729 + FMA:71222 + MA:0000290 + MAT:0000278 + MIAA:0000278 + NCIT:C49477 + SCTID:322050006 + VSAO:0000076 + Wikipedia:Appendicular_skeleton + XAO:0003166 appendicular skeleton + + + + Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]. + UBERONREF:0000003 + Wikipedia:Appendicular_skeleton + https://orcid.org/0000-0002-6601-2165 + @@ -112229,9 +170831,61 @@ - + Cardiac septum which separates the right ventricle from the left ventricle.[FMA]. + BTO:0002483 + EFO:0001956 + EHDAA:2603 + EMAPA:17333 + FMA:7133 + MA:0000085 + NCIT:C32874 + SCTID:362019005 + VHOG:0000386 + Wikipedia:Interventricular_septum + galen:InterventricularSeptum interventricular septum + + + + Cardiac septum which separates the right ventricle from the left ventricle.[FMA]. + FMA:7133 + + + + + + + + + + + + + + + Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon. + AAO:0011061 + BTO:0001380 + EV:0100083 + FMA:7144 + GAID:21 + MESH:D008643 + NCIT:C33103 + SCTID:362707009 + Wikipedia:Mesentery#Mesentery_.28general.29 + galen:Mesentery + mesentery + + + + + Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon. + FMA:7144 + Wikipedia:Mesentery + Wikipedia:Mesentery#Mesentery_.28general.29 + https://github.com/obophenotype/uberon/issues/85 + @@ -112258,9 +170912,28 @@ - + The organ covering the body that consists of the dermis and epidermis. + BTO:0001253 + CALOHA:TS-0934 + EFO:0000962 + EHDAA2:0001844 + EMAPA:17525 + FMA:7163 + MESH:D012867 + MFMO:0000099 + NCIT:C12470 + SCTID:181469002 + Wikipedia:Skin + XAO:0000023 + galen:Skin skin of body + + + + The organ covering the body that consists of the dermis and epidermis. + UBERON:cjm + @@ -112298,8 +170971,22 @@ + The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles. + EMAPA:35400 + FMA:7180 + GAID:562 + MA:0000083 + MESH:D006346 + NCIT:C49485 + SCTID:362014000 cardiac septum + + + + The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles. + MESH:A07.541.459 + @@ -112313,8 +171000,35 @@ + Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. + AAO:0010339 + BILA:0000116 + BTO:0001493 + CALOHA:TS-1071 + EFO:0000966 + EMAPA:31857 + FMA:7181 + MA:0000004 + MAT:0000296 + MIAA:0000296 + NCIT:C33816 + SCTID:262225004 + TAO:0001115 + Wikipedia:Torso + XAO:0000054 + XAO:0003025 + ZFA:0001115 + galen:Trunk trunk + + + + Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. + TAO:0001115 + UBERONREF:0000006 + Wikipedia:Torso + @@ -112328,8 +171042,27 @@ + The sensory system subserving the sense of vision. + AAO:0000632 + BILA:0000140 + EMAPA:36003 + FMA:7191 + MA:0002444 + NCIT:C12888 + SCTID:281831001 + TAO:0001127 + Wikipedia:Visual_system + XAO:0003198 + ZFA:0001127 + http://uri.neuinfo.org/nif/nifstd/FMAID_7191 visual system + + + + The sensory system subserving the sense of vision. + NIFSTD:FMAID_7191 + @@ -112343,8 +171076,300 @@ + Sensory system responsible for the perception of spatial orientation and auditory stimuli. + AAO:0000631 + FMA:78500 + TAO:0001138 + XAO:0003195 + ZFA:0001138 vestibulo-auditory system + + + + Sensory system responsible for the perception of spatial orientation and auditory stimuli. + ZFA:0001138 + + + + + + + + + + + + + + + + + + + + + + + The organ that functions to filter blood and to store red corpuscles and platelets. + AAO:0010395 + BTO:0001281 + CALOHA:TS-0956 + EFO:0000869 + EMAPA:18767 + EV:0100055 + FMA:7196 + GAID:1289 + MA:0000141 + MAT:0000085 + MESH:D013154 + MIAA:0000085 + NCIT:C12432 + SCTID:181279003 + TAO:0000436 + VHOG:0000120 + Wikipedia:Spleen + XAO:0000328 + ZFA:0000436 + galen:Spleen + spleen + + + + + The organ that functions to filter blood and to store red corpuscles and platelets. + ISBN:0-683-40008-8 + MP:0000689 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. + AAO:0010111 + BTO:0000759 + CALOHA:TS-0564 + EFO:0000887 + EHDAA2:0000997 + EHDAA:2197 + EMAPA:16846 + EV:0100089 + FMA:7197 + GAID:288 + MA:0000358 + MAT:0000097 + MESH:D008099 + MIAA:0000097 + NCIT:C12392 + SCTID:181268008 + TAO:0000123 + VHOG:0000257 + Wikipedia:Liver + XAO:0000133 + ZFA:0000123 + galen:Liver + liver + + + + + An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. + BTO:0000759 + Wikipedia:Liver + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]. + AAO:0010397 + BTO:0000651 + CALOHA:TS-0942 + EFO:0000841 + EMAPA:32834 + EV:0100072 + FMA:7200 + GAID:313 + MA:0000337 + MAT:0000047 + MESH:D007421 + MIAA:0000047 + NCIT:C12386 + SCTID:181250005 + TAO:0001323 + VHOG:0000055 + Wikipedia:Small_intestine + XAO:0000130 + ZFA:0001323 + galen:SmallIntestine + small intestine + + + + + Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]. + ISBN:0073040584 + Wikipedia:Small_intestine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An organ that aids digestion and stores bile produced by the liver[WP]. + AAO:0010114 + BTO:0000493 + CALOHA:TS-0394 + EFO:0000853 + EHDAA2:0000699 + EHDAA:8062 + EMAPA:17202 + EV:0100090 + FMA:7202 + MA:0000356 + MAT:0000072 + MESH:D005704 + MIAA:0000072 + NCIT:C12377 + SCTID:181269000 + TAO:0000208 + VHOG:0000221 + Wikipedia:Gallbladder + XAO:0000135 + ZFA:0000208 + galen:Gallbladder + Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988) + gallbladder + + + + + An organ that aids digestion and stores bile produced by the liver[WP]. + Wikipedia:Gallbladder + @@ -112370,8 +171395,21 @@ + A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]. + BTO:0000087 + CALOHA:TS-1198 + EMAPA:36285 + FMA:72024 + MA:0000708 + NCIT:C49195 artery smooth muscle tissue + + + + A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]. + OBOL:automatic + @@ -112402,8 +171440,77 @@ + A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]. + EMAPA:35323 + FMA:72025 + MA:0001573 smooth muscle of esophagus + + + + A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). + AAO:0010402 + BTO:0000365 + CALOHA:TS-0214 + EFO:0000851 + EMAPA:18852 + EV:0100073 + FMA:7206 + GAID:284 + MA:0000338 + MAT:0000044 + MESH:D004386 + MIAA:0000044 + NCIT:C12263 + SCTID:181247007 + VHOG:0000052 + Wikipedia:Duodenum + XAO:0000236 + galen:Duodenum + duodenum + + + + + The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). + ISBN:0815318960 + Wikipedia:Duodenum + @@ -112429,8 +171536,19 @@ + An ovary that is part of a right side of organism [Automatically generated definition]. + FMA:7213 + MA:0001705 + NCIT:C33487 + SCTID:280123002 right ovary + + + + An ovary that is part of a right side of organism [Automatically generated definition]. + OBOL:automatic + @@ -112456,8 +171574,19 @@ + An ovary that is part of a left side of organism [Automatically generated definition]. + FMA:7214 + MA:0001704 + NCIT:C32969 + SCTID:280124008 left ovary + + + + An ovary that is part of a left side of organism [Automatically generated definition]. + OBOL:automatic + @@ -112478,8 +171607,27 @@ + A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system. + BAMS:SOC + BIRNLEX:1307 + DHBA:12462 + EMAPA:35840 + EV:0100263 + FMA:72247 + HBA:9177 + MA:0001026 + MBA:398 + VHOG:0001381 + Wikipedia:Superior_olivary_complex superior olivary complex + + + + A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system. + ISBN:0-19-502694-2 + Wikipedia:Superior_olivary_complex + @@ -112501,8 +171649,37 @@ + The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]. + BAMS:CAE + BAMS:LC + BIRNLEX:905 + BM:Pons-LC + BTO:0001408 + DHBA:12819 + DMBA:16972 + EFO:0001963 + EMAPA:35502 + FMA:72478 + GAID:577 + HBA:9148 + MA:0001017 + MBA:147 + MESH:D008125 + NCIT:C97333 + SCTID:369016004 + TAO:0000539 + Wikipedia:Locus_ceruleus + ZFA:0000539 locus ceruleus + + + + The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]. + GAID:577 + GO:0021703 + Wikipedia:Locus_ceruleus + @@ -112524,8 +171701,26 @@ + Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703). + BAMS:SSN + BAMS:SuS + BIRNLEX:1131 + DHBA:12435 + EHDAA2:0004646 + FMA:72482 + HBA:9194 + MA:0001027 + MBA:462 + SCTID:369028007 + Wikipedia:Superior_salivatory_nucleus superior salivatory nucleus + + + + Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703). + BIRNLEX:1131 + @@ -112546,8 +171741,37 @@ + The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]. + AAO:0010408 + BTO:0000387 + CALOHA:TS-2075 + EFO:0000821 + EHDAA2:0004153 + EMAPA:17868 + EMAPA:32686 + EV:0100021 + FMA:7280 + GAID:550 + MA:0000076 + MAT:0000455 + MESH:D004699 + NCIT:C13004 + SCTID:362013006 + TAO:0001320 + VHOG:0000084 + Wikipedia:Endocardium + XAO:0000066 + ZFA:0001320 + galen:Endocardium + fixed in GO to reflect FMA. See email to David/Varsha June 18 2010 endocardium + + + + The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]. + GO:0003157 + @@ -112578,8 +171802,22 @@ + Endocardium that is part of the atrium. + EMAPA:32745 + FMA:7284 + MA:0000077 + SCTID:192001005 + TAO:0002169 + VHOG:0000606 + ZFA:0001614 endocardium of atrium + + + + Endocardium that is part of the atrium. + ZFIN:curator + @@ -112604,8 +171842,25 @@ + Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]. + EHDAA2:0001730 + EHDAA:4969 + EMAPA:17661 + FMA:7309 + MA:0000426 + NCIT:C33483 + SCTID:361967000 + VHOG:0000301 + Wikipedia:Right_lung right lung + + + + Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]. + FMA:FMA + Wikipedia:Right_lung + @@ -112630,8 +171885,25 @@ + Lung which consists of the left upper lobe and left lower lobe.[FMA]. + EHDAA2:0000943 + EHDAA:4947 + EMAPA:17653 + FMA:7310 + MA:0000425 + NCIT:C32967 + SCTID:361982005 + VHOG:0000618 + Wikipedia:Left_lung left lung + + + + Lung which consists of the left upper lobe and left lower lobe.[FMA]. + FMA:FMA + Wikipedia:Left_lung + @@ -112676,8 +171948,23 @@ + The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters. + BTO:0000061 + EMAPA:35119 + FMA:7317 + MA:0000418 + NCIT:C32057 + SCTID:361964007 + Wikipedia:Alveolar_sac alveolar sac + + + + The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters. + MP:0010902 + Wikipedia:Alveolar_sac + @@ -112691,9 +171978,22 @@ - + The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli. + EMAPA:32694 + FMA:7341 + MA:0000417 + NCIT:C32056 + Wikipedia:Alveolar_duct pulmonary alveolar duct + + + + The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli. + ISBN:0-683-40008-8 + MGI:cwg + MP:0002271 + @@ -112713,9 +172013,34 @@ - + The upper conducting airways of the lung; these airways arise from the terminus of the trachea. + BTO:0001340 + CALOHA:TS-1229 + EFO:0000932 + EMAPA:32689 + EV:0100041 + FMA:7409 + GAID:346 + MA:0000436 + MAT:0000133 + MESH:D001980 + MIAA:0000133 + NCIT:C12683 + SCTID:181215002 + VHOG:0000262 + Wikipedia:Bronchus + XAO:0000121 bronchus + + + + The upper conducting airways of the lung; these airways arise from the terminus of the trachea. + ISBN:0-397-51047-0 + MESH:A04.411.125 + MGI:cwg + MP:0002264 + @@ -112735,8 +172060,37 @@ + The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. + BTO:0002375 + CALOHA:TS-2003 + EHDAA:8171 + EHDAA:8183 + EHDAA:8199 + EHDAA:8221 + EMAPA:32697 + FMA:7410 + MA:0000422 + NCIT:C12684 + SCTID:278982001 + VHOG:0000675 + Wikipedia:Bronchiole + In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole. bronchiole + + + + The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. + ISBN:0-397-51047-0 + MGI:cwg + MP:0002267 + + + + + In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole. + https://github.com/obophenotype/uberon/issues/2795 + @@ -112762,9 +172116,25 @@ - + A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls. + BTO:0003223 + EMAPA:36282 + FMA:7411 + MA:0000424 + NCIT:C33754 + SCTID:278981008 + Wikipedia:Terminal_bronchiole terminal bronchiole + + + + A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls. + ISBN:0-397-51047-0 + MGI:cwg + MP:0002268 + PMID:16543587 + @@ -112796,9 +172166,23 @@ - + A bronchiole that is the first segment of the respiratory zone. + BTO:0003222 + EMAPA:35729 + FMA:7412 + MA:0000423 + NCIT:C33465 + SCTID:128517006 + Wikipedia:Respiratory_bronchiole respiratory bronchiole + + + + A bronchiole that is the first segment of the respiratory zone. + ISBN:0123813611 + Wikipedia:Respiratory_bronchiole + @@ -112830,9 +172214,19 @@ - + A portion of adipose tissue that is part of the hypodermis, beneath the dermis. + BTO:0004042 + EMAPA:35829 + FMA:74315 + MA:0000473 subcutaneous adipose tissue + + + + A portion of adipose tissue that is part of the hypodermis, beneath the dermis. + http://orcid.org/0000-0002-6601-2165 + @@ -112846,8 +172240,20 @@ + Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. + CALOHA:TS-2018 + EHDAA2:0004615 + EMAPA:18765 + FMA:74562 + MA:0000013 hemolymphoid system + + + + Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. + http://orcid.org/0000-0002-6601-2165 + @@ -112885,9 +172291,23 @@ - + The dermis, epidermis and hypodermis. + AAO:0000239 + BTO:0000634 + FMA:74657 + TAO:0000368 + VSAO:0000029 + Wikipedia:Integument + ZFA:0000368 + galen:Integument integument + + + + The dermis, epidermis and hypodermis. + Wikipedia:Integument + @@ -112912,8 +172332,20 @@ + Vasculature that is part of a head [Automatically generated definition]. + EFO:0003656 + FMA:74710 + TAO:0001267 + XAO:0004152 + ZFA:0001267 vasculature of head + + + + Vasculature that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -112938,8 +172370,18 @@ + A vasculature that is part of a trunk [Automatically generated definition]. + FMA:74712 + TAO:0005024 + ZFA:0005024 vasculature of trunk + + + + A vasculature that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -112965,9 +172407,21 @@ - + A submucosa that is part of a trachea. + BTO:0002115 + EMAPA:35879 + FMA:7472 + MA:0001860 + NCIT:C49307 + SCTID:4419000 submucosa of trachea + + + + A submucosa that is part of a trachea. + OBOL:automatic + @@ -112999,9 +172453,20 @@ - + Vasculature that is part of the eye region. + FMA:74743 + SCTID:123846009 + TAO:0007057 + ZFA:0007057 vasculature of eye + + + + Vasculature that is part of the eye region. + OBOL:automatic + https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726 + @@ -113039,14 +172504,39 @@ + + + Anatomical system that consists of the muscular and skeletal systems. + AAO:0010546 + CALOHA:TS-1311 + EMAPA:32714 + EV:0100139 + FMA:7482 + GAID:98 + MA:0002418 + MESH:D009141 + NCIT:C12754 + SCTID:278858007 + VHOG:0001275 + VSAO:0000031 + Wikipedia:Musculoskeletal_system + XAO:0000168 musculoskeletal system + + + + Anatomical system that consists of the muscular and skeletal systems. + VSAO:0000031 + VSAO:curator + https://github.com/obophenotype/uberon/issues/77 + @@ -113071,8 +172561,23 @@ + Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]. + EMAPA:36581 + FMA:7496 + MA:0000320 + SCTID:58442004 + TAO:0005155 + Wikipedia:Cartilaginous_joint + ZFA:0005155 cartilaginous joint + + + + Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]. + FMA:FMA + Wikipedia:Cartilaginous_joint + @@ -113104,8 +172609,27 @@ + Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]. + AEO:0000183 + CALOHA:TS-2138 + EHDAA2:0003183 + FMA:7501 + MA:0000322 + NCIT:C32461 + SCTID:113234001 + TAO:0005153 + Wikipedia:Synovial_joint + ZFA:0005153 + galen:SynovialJoint synovial joint + + + + Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]. + FMA:7501 + Wikipedia:Synovial_joint + @@ -113140,8 +172664,24 @@ + The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. + EMAPA:36497 + FMA:7565 + GAID:93 + MA:0000032 + MESH:D035423 + NCIT:C12905 + SCTID:243949006 + Wikipedia:Thoracic_cavity thoracic cavity + + + + The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. + UBERON:cjm + Wikipedia:Thoracic_cavity + @@ -113182,9 +172722,42 @@ - + Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO). + AAO:0010151 + BAMS:SP + BAMS:Spinal + BIRNLEX:1709 + BM:SpC + BTO:0001279 + CALOHA:TS-0953 + DHBA:12890 + DMBA:17651 + EFO:0000110 + EHDAA2:0001255 + EHDAA:2863 + EMAPA:17577 + EV:0100316 + FMA:7647 + GAID:695 + MA:0000216 + MAT:0000183 + MESH:D013116 + MIAA:0000183 + NCIT:C12464 + SCTID:180959008 + TAO:0000075 + VHOG:0000601 + Wikipedia:Spinal_cord + XAO:0000020 + ZFA:0000075 spinal cord + + + + Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO). + BIRNLEX:1709 + @@ -113198,8 +172771,23 @@ + Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]. + AAO:0010169 + EHDAA2:0000243 + EMAPA:17681 + TAO:0001424 + VHOG:0000288 + Wikipedia:Chondrocranium + ZFA:0001424 chondrocranium + + + + Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]. + Wikipedia:Chondrocranium + http://medical-dictionary.thefreedictionary.com/chondrocranium + @@ -113232,8 +172820,32 @@ + The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]. + BAMS:VH + BIRNLEX:2668 + BTO:0005151 + EMAPA:18575 + EMAPA:35794 + FMA:256541 + MA:0001134 + NCIT:C33859 + SCTID:279443000 + TAO:0000702 + VHOG:0001288 + Wikipedia:Anterior_horn_of_spinal_cord + ZFA:0000702 + neuronames:1751 ventral horn of spinal cord + + + + The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]. + GO:0021517 + MP:0005112 + Wikipedia:Anterior_horn_of_spinal_cord + https://sourceforge.net/tracker/?group_id=36855&atid=440764 + @@ -113247,8 +172859,139 @@ + A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ). + BAMS:RET + EMAPA:35188 + FMA:77719 + MA:0003185 + MESH:D012154 + NLX:143558 + SCTID:361552007 + Wikipedia:Reticular_formation + neuronames:1223 reticular formation + + + + A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ). + NeuroNames:1223 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree). + FMA:79646 + GAID:279 + MA:0001273 + MESH:D001659 + NCIT:C12678 + SCTID:361354009 + Wikipedia:Biliary_system + biliary system + + + + + Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree). + Wikipedia:Biliary_system + + + + + + + + + + + + + + + + + + + + + The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]. + EHDAA2:0004560 + EHDAA:3019 + EHDAA:3033 + EHDAA:3921 + EHDAA:3934 + EHDAA:3957 + EHDAA:3971 + FMA:79795 + SCTID:308823000 + TAO:0005130 + Wikipedia:Mesentery#Development + ZFA:0005130 + dorsal mesentery + + + + + The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]. + Wikipedia:Dorsal_mesentery + Wikipedia:Mesentery#Development + ZFIN:curator + @@ -113280,8 +173023,36 @@ + Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. + BAMS:BS + BIRNLEX:1565 + BTO:0000146 + CALOHA:TS-0093 + EFO:0001962 + EMAPA:32678 + EV:0100241 + FMA:79876 + MA:0000169 + MBA:343 + MESH:D001933 + NCIT:C12441 + SCTID:180925009 + TAO:0002156 + VHOG:0001457 + Wikipedia:Brainstem + ZFA:0001707 + 'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions). brainstem + + + + Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. + ISBN:0471888893 + MP:0005277 + Wikipedia:Brainstem + ZFA:0001707 + @@ -113331,9 +173102,26 @@ - + Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]. + BTO:0000060 + CALOHA:TS-0031 + EFO:0001985 + EMAPA:32682 + FMA:7318 + GAID:349 + MA:0000420 + MESH:D011650 + SCTID:361364000 + VHOG:0001445 + Wikipedia:Pulmonary_alveolus alveolus of lung + + + + Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]. + Wikipedia:Pulmonary_alveolus + @@ -113364,8 +173152,24 @@ + The atrial part of middle layer of the heart, comprised of involuntary muscle. + EFO:0003087 + EMAPA:32746 + FMA:83509 + MA:0000081 + SCTID:191910002 + TAO:0001374 + VHOG:0000602 + ZFA:0001374 myocardium of atrium + + + + The atrial part of middle layer of the heart, comprised of involuntary muscle. + ISBN:0-683-40008-8 + MP:0010493 + @@ -113390,8 +173194,21 @@ + A neural nucleus that is part of the brain. + EMAPA:35185 + FMA:83840 + MA:0000811 + NCIT:C49346 + SCTID:426465002 + ZFA:0005575 nucleus of brain + + + + A neural nucleus that is part of the brain. + http://orcid.org/0000-0002-6601-2165 + @@ -113422,8 +173239,24 @@ + The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue. + BAMS:Scgrey + DHBA:146035048 + EMAPA:35792 + FMA:256580 + MA:0000002 + NCIT:C32696 + NLXANAT:100204 + SCTID:279441003 + neuronames:2619 gray matter of spinal cord + + + + The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue. + MP:0008503 + @@ -113443,8 +173276,26 @@ + The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. + AEO:0000186 + BTO:0001707 + EHDAA2:0000267 + FMA:85006 + NCIT:C25444 + RETIRED_EHDAA2:0003186 + SCTID:361348008 + TAO:0001438 + ZFA:0001438 + galen:BodyCavity + EDITOR_NOTE check the FMA placement here; ncit placement of body cavity here probably not correct coelemic cavity lumen + + + + The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. + BTO:0001707 + @@ -113470,9 +173321,18 @@ - + Any muscle organ that is part of a back [Automatically generated definition]. + EMAPA:35161 + FMA:85216 + MA:0000496 muscle of back + + + + Any muscle organ that is part of a back [Automatically generated definition]. + OBOL:automatic + @@ -113531,8 +173391,41 @@ + A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. + AAO:0000327 + BTO:0001768 + CALOHA:TS-0690 + EHDAA2:0001277 + EHDAA:1241 + EHDAA:6021 + EMAPA:16191 + EV:0100002 + FMA:85521 + GAID:1311 + MAT:0000281 + MESH:D009672 + NCIT:C12463 + SCTID:308820002 + TAO:0000135 + VHOG:0000199 + VSAO:0000032 + Wikipedia:Notochord + XAO:0000055 + ZFA:0000135 + http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg + The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB] notochord + + + + A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. + ISBN:0815318960 + Wikipedia:Notochord + http://tolweb.org/Chordata/2499 + https://github.com/obophenotype/uberon/issues/25 + https://github.com/obophenotype/uberon/issues/271 + @@ -113553,8 +173446,35 @@ + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. + AAO:0010569 + AEO:0001015 + BTO:0001558 + EHDAA2:0003436 + EHDAA:366 + EHDAA:699 + EMAPA:31169 + FMA:85522 + GAID:1306 + MAT:0000068 + MESH:D019170 + MIAA:0000068 + NCIT:C34302 + TAO:0000155 + VHOG:0000191 + Wikipedia:Somite + XAO:0000058 + ZFA:0000155 + When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248] somite + + + + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. + DOI:10.1111/j.1439-0426.2012.01987.x + Wikipedia:Somite + @@ -113583,10 +173503,26 @@ + + Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. + CALOHA:TS-2057 + EHDAA2:0002225 + EMAPA:35329 + FMA:85539 + MA:0002411 + NCIT:C12957 + Wikipedia:Exocrine_gland + WikipediaCategory:Exocrine_system exocrine system + + + + Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. + Wikipedia:Exocrine_gland + @@ -113612,9 +173548,23 @@ - + An arterial trunk which is continuous with the heart and branches into the pulmonary arteries. + EHDAA2:0001576 + EHDAA:9831 + EMAPA:17015 + FMA:8612 + MA:0002033 + NCIT:C116918 + VHOG:0001134 + galen:PulmonaryTrunk pulmonary trunk + + + + An arterial trunk which is continuous with the heart and branches into the pulmonary arteries. + http://orcid.org/0000-0002-6601-2165 + @@ -113640,8 +173590,19 @@ + A lamina propria that is part of a bronchus [Automatically generated definition]. + EMAPA:35194 + FMA:86619 + MA:0001836 + NCIT:C49212 lamina propria of bronchus + + + + A lamina propria that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -113687,8 +173648,33 @@ + A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. + AAO:0010578 + BTO:0001764 + CALOHA:TS-0676 + EHDAA2:0004419 + EMAPA:32737 + FMA:86666 + GAID:1310 + MAT:0000066 + MESH:D009432 + MIAA:0000066 + NCIT:C34222 + SCTID:361462002 + VHOG:0000057 + Wikipedia:Neural_crest + XAO:0000048 + ZFA:0000045 + neuronames:1366 + Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. neural crest + + + + A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. + MP:0009846 + @@ -113713,8 +173699,19 @@ + Set of all muscles in abdomen. + FMA:71294 + FMA:86917 + TAO:0001327 + ZFA:0001327 abdomen musculature + + + + Set of all muscles in abdomen. + OBOL:automatic + @@ -113747,9 +173744,20 @@ - + The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + EFO:0002527 + EMAPA:18605 + FMA:87217 + MA:0002572 + SCTID:181301002 descending thoracic aorta + + + + The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + MP:0009868 + @@ -113764,8 +173772,76 @@ + Embryonic ectoderm that gives rise to nervous tissue. + AAO:0011074 + BILA:0000039 + CALOHA:TS-1212 + EHDAA2:0001248 + EHDAA:1498 + EHDAA:255 + EMAPA:16073 + EV:0100004 + FMA:87657 + MAT:0000176 + MIAA:0000176 + NCIT:C34228 + TAO:0001120 + VHOG:0000150 + Wikipedia:Neuroectoderm + XAO:0000042 + ZFA:0001120 neurectoderm + + + + Embryonic ectoderm that gives rise to nervous tissue. + Wikipedia:Neuroectoderm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A thoracic vertebra endochondral element that is composed primarily of a bone tissue. + EMAPA:18011 + FMA:9139 + GAID:244 + MA:0000314 + MESH:D013904 + NCIT:C12798 + SCTID:181821009 + Wikipedia:Thoracic_vertebrae + thoracic vertebra + + + + + A thoracic vertebra endochondral element that is composed primarily of a bone tissue. + OBOL:automatic + @@ -113798,9 +173874,26 @@ - + A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart. + AAO:0010409 + EHDAA2:0002202 + FMA:9461 + NCIT:C13164 + TAO:0005057 + VHOG:0000119 + Wikipedia:Epicardium + XAO:0000316 + ZFA:0005057 + galen:Epicardium + EDITOR_NOTE TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer. epicardium + + + + A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -113838,8 +173931,38 @@ + The middle layer of the heart, comprised mainly of striated cardiac muscle fibers. + AAO:0010410 + BSA:0000089 + BTO:0000901 + CALOHA:TS-0440 + EFO:0000819 + EHDAA2:0004150 + EV:0100022 + FMA:9462 + GAID:173 + MA:0000164 + MAT:0000453 + MESH:D009206 + NCIT:C12371 + RETIRED_EHDAA2:0001220 + SCTID:362012001 + TAO:0001319 + VHOG:0000083 + Wikipedia:Myocardium + XAO:0000065 + ZFA:0001319 + galen:Myocardium + EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium myocardium + + + + The middle layer of the heart, comprised mainly of striated cardiac muscle fibers. + ISBN:0-683-40008-8 + MP:0005329 + @@ -113884,8 +174007,26 @@ + The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]. + EFO:0003909 + EHDAA2:0004185 + EMAPA:35428 + EV:0100025 + FMA:9476 + MA:0000094 + MESH:D006329 + SCTID:281489000 + TAO:0005063 + VHOG:0001271 + ZFA:0005063 conducting system of heart + + + + The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]. + GO:0003161 + @@ -113924,9 +174065,29 @@ - + The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]. + BTO:0004358 + EHDAA2:0004184 + EMAPA:35772 + FMA:9477 + GAID:561 + MA:0000097 + MESH:D012849 + NCIT:C33555 + SCTID:277687007 + TAO:0005069 + Wikipedia:Sinoatrial_node + ZFA:0005069 + WP:Heart states: "The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.". Note however that ZFA has SA node. sinoatrial node + + + + The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]. + GO:0003163 + Wikipedia:Sinoatrial_node + @@ -113960,9 +174121,31 @@ - + An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles. + BTO:0005689 + EFO:0000276 + EHDAA2:0004183 + EMAPA:35153 + FMA:9478 + GAID:558 + MA:0000095 + MAT:0000498 + MESH:D001283 + NCIT:C32161 + SCTID:277688002 + TAO:0005070 + VHOG:0001474 + Wikipedia:Atrioventricular_node + ZFA:0005070 atrioventricular node + + + + An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles. + UBERON:cjm + Wikipedia:Atrioventricular_node + @@ -113989,8 +174172,23 @@ + The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. + BTO:0001735 + EMAPA:35718 + FMA:9492 + GAID:560 + MA:0000096 + MESH:D011690 + NCIT:C33430 + Wikipedia:Purkinje_fiber cardiac Purkinje fiber + + + + The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. + GO:0003165 + @@ -114022,8 +174220,21 @@ + Serous membrane which is divided into parietal and visceral serous pericardium. + EMAPA:19030 + FMA:9582 + MA:0002739 + SCTID:243954002 + Wikipedia:Serous_pericardium serous pericardium + + + + Serous membrane which is divided into parietal and visceral serous pericardium. + Wikipedia:Serous_pericardium + http://orcid.org/0000-0002-6601-2165 + @@ -114054,8 +174265,30 @@ + A serous membrane that lines the peritoneal cavity[VHOG,modified]. + AAO:0010814 + BTO:0001472 + CALOHA:TS-2072 + EV:0100087 + FMA:9584 + GAID:18 + MA:0000449 + MESH:D010537 + NCIT:C12770 + TAO:0005120 + VHOG:0001257 + Wikipedia:Peritoneum + XAO:0000139 + ZFA:0005120 + galen:Peritoneum peritoneum + + + + A serous membrane that lines the peritoneal cavity[VHOG,modified]. + VHOG:0001257 + @@ -114082,8 +174315,20 @@ + Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]. + EMAPA:19029 + FMA:9586 + MA:0002738 + SCTID:243953008 + Wikipedia:Fibrous_pericardium fibrous pericardium + + + + Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]. + FMA:9586 + @@ -114114,8 +174359,27 @@ + A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas. + AEO:0000097 + BTO:0000765 + CALOHA:TS-2012 + EHDAA2:0003097 + EMAPA:35327 + FMA:9596 + GAID:34 + MA:0002564 + MESH:D005088 + NCIT:C12712 + SCTID:115976003 + Wikipedia:Exocrine_gland exocrine gland + + + + A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas. + Wikipedia:Exocrine_gland + @@ -114146,8 +174410,27 @@ + Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]. + AEO:0000098 + BTO:0001488 + CALOHA:TS-1300 + EHDAA2:0003098 + EMAPA:35999 + FMA:9602 + GAID:335 + MA:0002563 + MESH:D004702 + NCIT:C12704 + SCTID:40818001 + Wikipedia:Endocrine_gland endocrine gland + + + + Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]. + Wikipedia:Endocrine_gland + @@ -114201,9 +174484,35 @@ - + The soft tissue that fills the cavities of bones. + AAO:0011007 + BTO:0000141 + BTO:0000829 + CALOHA:TS-0087 + EFO:0000868 + EMAPA:32760 + EV:0100046 + FMA:9608 + GAID:1287 + MA:0000134 + MAT:0000084 + MESH:D001853 + MIAA:0000084 + NCIT:C12431 + SCTID:421320006 + VHOG:0001218 + Wikipedia:Bone_marrow + XAO:0000123 + galen:BoneMarrow bone marrow + + + + The soft tissue that fills the cavities of bones. + MGI:cwg + MP:0002397 + @@ -114245,9 +174554,25 @@ - + Any skeletal muscle that is part of the head region. + AAO:0000107 + BTO:0000021 + EFO:0003524 + EHDAA2:0000322 + EMAPA:18172 + FMA:9616 + MA:0000578 + SCTID:244718003 + ZFA:0001652 + defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984) cranial muscle + + + + Any skeletal muscle that is part of the head region. + http://orcid.org/0000-0002-6601-2165 + @@ -114272,9 +174597,20 @@ - + Any muscle that is part of the cervical (neck) region. + FMA:9617 + GAID:149 + MA:0000587 + MESH:D009334 + NCIT:C33163 muscle of neck + + + + Any muscle that is part of the cervical (neck) region. + http://orcid.org/0000-0002-6601-2165 + @@ -114306,9 +174642,24 @@ - + Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis. + BTO:0001261 + EMAPA:35103 + FMA:9620 + GAID:89 + MA:0000520 + MESH:D000009 + NCIT:C32040 + SCTID:361352008 + Wikipedia:Abdominal_muscle muscle of abdomen + + + + Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis. + Wikipedia:Abdominal_muscle + @@ -114322,9 +174673,37 @@ - + Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. + AAO:0000098 + BTO:0000421 + CALOHA:TS-2009 + EFO:0000952 + EMAPA:35251 + FMA:9640 + GAID:100 + MA:0000011 + MAT:0000301 + MESH:D003238 + MIAA:0000301 + NCIT:C12374 + SCTID:361919005 + TAO:0001641 + VSAO:0000017 + XAO:0001017 + ZFA:0001632 + galen:ConnectiveTissue connective tissue + + + + Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000017 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/23 + @@ -114369,8 +174748,30 @@ + Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. + AAO:0000306 + AEO:0000122 + CALOHA:TS-0642 + EHDAA2:0003122 + EMAPA:32715 + FMA:9641 + MA:0002437 + MESH:D009132 + NCIT:C12435 + SCTID:91727004 + Wikipedia:Muscle_tissue + galen:MuscleTissue + Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach. muscle tissue + + + + Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. + GO:0060537 + Wikipedia:Muscle_tissue + https://sourceforge.net/tracker/index.php?func=detail&aid=2801266&group_id=36855&atid=440764 + @@ -114399,11 +174800,146 @@ + - + Anatomical system that is involved in the production of hematopoietic cells. + AAO:0011002 + BTO:0000570 + CALOHA:TS-0449 + EFO:0000798 + EMAPA:35402 + EV:0100045 + FMA:9667 + GAID:1008 + MA:0002434 + MAT:0000022 + MESH:D006413 + MIAA:0000022 + NCIT:C12909 + SCTID:362587009 + TAO:0005023 + VHOG:0001624 + Wikipedia:Haematopoiesis + XAO:0000122 + ZFA:0005023 hematopoietic system + + + + Anatomical system that is involved in the production of hematopoietic cells. + Wikipedia:Haematopoiesis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine. + AAO:0011019 + BTO:0000122 + CALOHA:TS-0075 + EMAPA:35171 + EV:0100091 + FMA:9706 + GAID:280 + MA:0000354 + MESH:D001652 + NCIT:C12376 + SCTID:276157007 + TAO:0001100 + VHOG:0000212 + Wikipedia:Bile_duct + XAO:0000134 + ZFA:0001100 + bile duct + + + + + Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine. + Wikipedia:Bile_duct + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + The triangular flat bone of the nasal septum. + AAO:0000633 + FMA:9710 + MA:0001496 + NCIT:C33888 + SCTID:272678009 + TAO:0000308 + Wikipedia:Vomer + ZFA:0000308 + vomer + + + + + The triangular flat bone of the nasal septum. + ISBN:0-683-40008-8 + MP:0000098 + @@ -114451,8 +174987,24 @@ + The outer serous membrane of the pulmonary pleural. + EMAPA:16776 + FMA:9733 + MA:0002488 + NCIT:C33273 + SCTID:361998003 + VHOG:0001495 + Wikipedia:Parietal_pleura + the part of the pleura external to the visceral pleura. It lines the inner surface of the chest wall, covers the diaphragm, and is reflected over the structures occupying the middle of the thorax parietal pleura + + + + The outer serous membrane of the pulmonary pleural. + UBERON:cjm + Wikipedia:Pulmonary_pleurae + @@ -114506,9 +175058,23 @@ - + The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs. + EHDAA2:0002205 + EMAPA:16777 + FMA:9734 + MA:0002489 + NCIT:C33881 + SCTID:361997008 + VHOG:0001496 visceral pleura + + + + The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs. + UBERON:cjm + Wikipedia:Pulmonary_pleurae + @@ -114551,8 +175117,28 @@ + The fluid-filled cavity that lies between the visceral and parietal pleurae. + BTO:0004422 + EHDAA2:0001475 + EMAPA:16773 + EMAPA:16774 + FMA:9740 + GAID:95 + MA:0000055 + MESH:D035422 + NCIT:C12840 + SCTID:361999006 + VHOG:0000581 + Wikipedia:Pleural_cavity pleural cavity + + + + The fluid-filled cavity that lies between the visceral and parietal pleurae. + Wikipedia:Pleural_cavity + https://github.com/obophenotype/uberon/issues/86 + @@ -114579,11 +175165,32 @@ + - + Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies. + AAO:0011003 + BILA:0000104 + BTO:0005810 + FMA:9825 + GAID:328 + MA:0002711 + MESH:D007107 + NCIT:C12735 + SCTID:362590003 + TAO:0001159 + VHOG:0001247 + Wikipedia:Immune_system + XAO:0003152 + ZFA:0001159 immune system + + + + Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies. + Wikipedia:Immune_system + @@ -114631,8 +175238,19 @@ + A double-walled sac containing the heart and the roots of the great vessels. + FMA:9868 + RETIRED_EHDAA2:0001443 + SCTID:361326002 pericardial sac + + + + A double-walled sac containing the heart and the roots of the great vessels. + Wikipedia:Pericardium + https://github.com/obophenotype/uberon/issues/86 + @@ -114664,9 +175282,36 @@ - + The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium. + AAO:0010817 + BSA:0000090 + BTO:0000717 + CALOHA:TS-0761 + EFO:0000820 + EHDAA:5376 + EV:0100023 + FMA:9869 + GAID:569 + MA:0000099 + MAT:0000454 + MESH:D010496 + NCIT:C13005 + RETIRED_EHDAA2:0001443 + SCTID:181295003 + VHOG:0001280 + Wikipedia:Pericardium + XAO:0004182 + ZFA:0000054 + galen:Pericardium pericardium + + + + The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium. + Wikipedia:Pericardium + http://orcid.org/0000-0002-6601-2165 + @@ -114691,8 +175336,24 @@ + Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac. + EHDAA:3422 + EHDAA:5378 + EMAPA:19031 + FMA:9870 + MA:0000483 + NCIT:C94500 + SCTID:243956000 + VHOG:0000537 + Wikipedia:Parietal_pericardium parietal serous pericardium + + + + Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac. + http://orcid.org/0000-0002-6601-2165 + @@ -114724,8 +175385,20 @@ + Transudate contained in the pericardial cavity.[FMA]. + BTO:0001016 + FMA:9887 + MA:0002530 + Wikipedia:Pericardial_fluid pericardial fluid + + + + Transudate contained in the pericardial cavity.[FMA]. + FMA:9887 + Wikipedia:Pericardial_fluid + @@ -114751,8 +175424,177 @@ + The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]. + AAO:0000033 + BIRNLEX:1123 + BTO:0002507 + CALOHA:TS-2001 + EHDA:10095 + EHDAA2:0000158 + EHDAA:3767 + EMAPA:16984 + FMA:65553 + GAID:706 + MA:0000219 + MESH:D001341 + NCIT:C12673 + SCTID:362481007 + TAO:0001574 + VHOG:0000396 + Wikipedia:Autonomic_nervous_system + ZFA:0001574 + neuronames:2054 autonomic nervous system + + + + The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]. + GO:0048483 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + AAO:0000691 + CALOHA:TS-2352 + EFO:0001371 + EMAPA:32740 + FMA:9914 + MA:0000309 + NCIT:C12933 + SCTID:181817002 + TAO:0001189 + Wikipedia:Vertebra + XAO:0004019 + ZFA:0001189 + galen:Vertebra + vertebra + + + + + The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + GO_REF:0000034 + VSAO:0000184 + http://dx.plos.org/10.1371/journal.pone.0051070 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vertebra that is located in the cervical region of the vertebral column. + EMAPA:17674 + FMA:9915 + GAID:235 + MA:0000311 + MESH:D002574 + NCIT:C12693 + SCTID:181820005 + Wikipedia:Cervical_vertebrae + XAO:0003076 + galen:CervicalVertebra + cervical vertebra + + + + + A vertebra that is located in the cervical region of the vertebral column. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail. + AEO:0000109 + BILA:0000117 + BTO:0001348 + EFO:0000963 + EHDAA:9198 + GAID:1245 + MAT:0000094 + MESH:D013623 + MIAA:0000094 + WBbt:0005741 + Wikipedia:Tail + tail + + + + + An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail. + AEO:0000109 + Wikipedia:Tail + @@ -114784,11 +175626,43 @@ + - + Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. + AEO:0000154 + BILA:0000118 + CALOHA:TS-1299 + CARO:0002001 + EFO:0000807 + EHDAA2:0000836 + EHDAA2_RETIRED:0003154 + EHDAA:6520 + EMAPA:17524 + EV:0100151 + FMA:72979 + HAO:0000421 + MA:0000014 + MAT:0000033 + MESH:D034582 + MIAA:0000033 + NCIT:C12907 + SCTID:361692004 + TADS:0000108 + VHOG:0000403 + Wikipedia:Integumentary_system + XAO:0000176 + galen:Surface integumental system + + + + Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. + CARO:0002001 + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/29 + @@ -114797,8 +175671,20 @@ + The abdominal segment of the torso. + EMAPA:35104 + FMA:259211 + MA:0000021 + SCTID:362875007 + Wikipedia:Lumbar abdominal segment of trunk + + + + The abdominal segment of the torso. + Wikipedia:Lumbar + @@ -114830,8 +175716,44 @@ + Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts. + AAO:0000060 + AEO:0000087 + BTO:0000206 + EFO:0000949 + EHDAA2:0003087 + EMAPA:32730 + EV:0100141 + FMA:37377 + GAID:99 + MA:0000104 + MAT:0000189 + MESH:D002356 + MIAA:0000189 + NCIT:C12373 + NCIT:C32268 + SCTID:309312004 + TAO:0001501 + VHOG:0001207 + VSAO:0000040 + Wikipedia:Cartilage + XAO:0000170 + ZFA:0005622 + galen:Cartilage + Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W] cartilage tissue + + + + Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000040 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/37 + https://sourceforge.net/p/obo/vertebrate-skeletal-anatomy-vsao-term-requests/5 + @@ -114858,8 +175780,89 @@ + A gland that is part of a skin of body [Automatically generated definition]. + EMAPA:35774 + FMA:71878 + MA:0000146 + SCTID:110485007 skin gland + + + + A gland that is part of a skin of body [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the digestive system that contains the liver and the biliary system. + AAO:0011056 + CALOHA:TS-1308 + EFO:0000800 + EHDAA2:0000998 + EHDAA:2189 + EMAPA:16840 + EV:0100088 + MA:0000324 + MAT:0000024 + MIAA:0000024 + NCIT:C43612 + TAO:0000036 + VHOG:0000294 + Wikipedia:Hepatobiliary_system + XAO:0000132 + ZFA:0000036 + hepatobiliary system + + + + + The part of the digestive system that contains the liver and the biliary system. + http://orcid.org/0000-0002-6601-2165 + @@ -114891,8 +175894,29 @@ + An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues. + AAO:0010357 + BTO:0001775 + CALOHA:TS-0715 + EHDAA2:0001325 + EHDAA:2187 + EMAPA:16839 + EMAPA:26942 + FMA:265152 + MA:0000344 + NCIT:C49595 + TAO:0000816 + VHOG:0000187 + XAO:0003201 + ZFA:0000816 oral epithelium + + + + An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues. + https://orcid.org/0000-0002-6601-2165 + @@ -114935,8 +175959,21 @@ + Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]. + EMAPA:19032 + FMA:84882 + MA:0000484 + SCTID:243955001 + VHOG:0000538 + Wikipedia:Visceral_pericardium visceral serous pericardium + + + + Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]. + Wikipedia:Visceral_pericardium + @@ -114962,8 +175999,19 @@ + A blood vessel that is part of a choroid [Automatically generated definition]. + EMAPA:17828 + FMA:76550 + MA:0001237 + cannot find singular in FMA, using Set class choroidal blood vessel + + + + A blood vessel that is part of a choroid [Automatically generated definition]. + OBOL:automatic + @@ -114972,8 +176020,24 @@ + The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries. + EHDAA2:0000882 + EHDAA:4340 + EMAPA:17616 + MA:0001985 + SCTID:360401001 + TAO:0001061 + VHOG:0000225 + XAO:0004165 + ZFA:0001061 intersomitic artery + + + + The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries. + MP:0010662 + @@ -114998,8 +176062,65 @@ + Arteries that supply the spinal cord. + EHDAA2:0001890 + EHDAA:4355 + EMAPA:18241 + MA:0002043 + NCIT:C33587 + SCTID:244228006 + TAO:0000682 + Wikipedia:Spinal_artery + ZFA:0000682 spinal artery + + + + Arteries that supply the spinal cord. + Wikipedia:Spinal_artery + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine. + BTO:0000644 + FMA:62974 + GAID:1162 + MA:0002515 + MESH:D007419 + NCIT:C32875 + Wikipedia:Succus_entericus + intestine secretion + + + + + Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine. + Wikipedia:Succus_entericus + @@ -115024,8 +176145,21 @@ + A mucosa that is part of a esophagus [Automatically generated definition]. + BTO:0002859 + EMAPA:26981 + FMA:62996 + MA:0002680 + NCIT:C32538 + SCTID:362127004 esophagus mucosa + + + + A mucosa that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -115046,8 +176180,29 @@ + Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts. + CALOHA:TS-2011 + EMAPA:35179 + FMA:224804 + MA:0002780 + MESH:D001842 + NCIT:C13076 + VSAO:0000047 + Wikipedia:Bone_tissue + XAO:0004040 + ZFA:0005621 + galen:BoneTissue bone tissue + + + + Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000047 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -115085,9 +176240,53 @@ - + An epithelium that is part of a iris [Automatically generated definition]. + EMAPA:35447 + FMA:58517 + MA:0002826 iris epithelium + + + + An epithelium that is part of a iris [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + The supporting bundles of muscular fibers lining the walls of the ventricles of the heart. + EMAPA:18626 + FMA:7269 + MA:0002831 + SCTID:118755002 + Wikipedia:Trabeculae_carneae + trabecula carnea + + + + + The supporting bundles of muscular fibers lining the walls of the ventricles of the heart. + MGI:monikat + MP:0004067 + @@ -115125,8 +176324,28 @@ + Replacement bone that forms within cartilage. + AAO:0010776 + AEO:0000083 + BTO:0002157 + EHDAA2:0003083 + FMA:24321 + TAO:0001591 + VSAO:0000145 + XAO:0004018 + ZFA:0001591 endochondral bone + + + + Replacement bone that forms within cartilage. + GO:0001958 + GO_REF:0000034 + VSAO:0000145 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/54 + @@ -115146,8 +176365,63 @@ + Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. + EMAPA:36615 + TAO:0001644 + Wikipedia:Intramembranous_ossification + ZFA:0001635 intramembranous bone + + + + Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. + GO:0001957 + Wikipedia:Intramembranous_ossification + https://github.com/obophenotype/uberon/issues/267 + + + + + + + + + + + + + + + + + + + + + + + + + + + The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof. + FMA:52801 + MA:0002840 + MESH:D019291 + MFMO:0000044 + NCIT:C12493 + SCTID:181890004 + Wikipedia:Base_of_skull + The skull base is formed from a series of cartilages either side of, and rostral to, the notochord, whose tip lies just caudal to the pituitary gland. It is closely associated with the sensory capsules, which partially or completely sur- round the olfactory epithelium, the eye, and the inner ear[PMID:11523816] + basicranium + + + + + The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof. + Wikipedia:Base_of_skull + @@ -115178,8 +176452,22 @@ + Connective tissue composed of elastic fibers. + FMA:20113 + GAID:926 + MA:0002853 + MESH:D004547 + NCIT:C32495 + SCTID:27197004 + Wikipedia:Elastic_fiber elastic tissue + + + + Connective tissue composed of elastic fibers. + http://orcid.org/0000-0002-6601-2165 + @@ -115205,8 +176493,25 @@ + The middle layer of an artery or vein. [WP,unvetted]. + BTO:0002011 + EMAPA:36298 + FMA:55590 + GAID:170 + MA:0002855 + MESH:D017540 + NCIT:C33821 + SCTID:61695000 + Wikipedia:Tunica_media + May be composed of smooth muscle and elastic tissue tunica media + + + + The middle layer of an artery or vein. [WP,unvetted]. + Wikipedia:Tunica_media + @@ -115232,8 +176537,27 @@ + The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]. + BTO:0002012 + EMAPA:36297 + FMA:55589 + GAID:523 + MA:0002861 + MESH:D017539 + NCIT:C33820 + SCTID:8361002 + SCTID:87483006 + Wikipedia:Tunica_intima tunica intima + + + + The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]. + ISBN:0073040584 + NCIT:C33820 + Wikipedia:Tunica_intima + @@ -115259,8 +176583,34 @@ + An organ that functions as a secretory or excretory organ. + AAO:0000212 + AEO:0000096 + BTO:0000522 + EFO:0000797 + EHDAA2:0003096 + EHDAA:2161 + EMAPA:18425 + FMA:7146 + FMA:86294 + HAO:0000375 + MA:0003038 + MAT:0000021 + MIAA:0000021 + NCIT:C13319 + SCTID:134358001 + Wikipedia:Gland + WikipediaCategory:Glands + galen:Gland gland + + + + An organ that functions as a secretory or excretory organ. + MGI:csmith + MP:0002163 + @@ -115274,8 +176624,56 @@ + In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]. + BTO:0004593 + FMA:296704 + MAT:0000067 + MIAA:0000067 + VHOG:0000243 + Wikipedia:Epiblast epiblast (generic) + + + + In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]. + Wikipedia:Epiblast + ZFIN:curator + + + + + + + + + + + + + + + The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node. + AAO:0011104 + BTO:0001445 + EFO:0002748 + EHDAA2:0001976 + EHDAA:1595 + EMAPA:16580 + MAT:0000070 + MIAA:0000070 + TAO:0000077 + VHOG:0000201 + XAO:0000107 + ZFA:0000077 + post-anal tail bud + + + + + The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node. + BTO:0001445 + @@ -115295,8 +176693,23 @@ + Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt]. + BTO:0001237 + EFO:0000939 + HAO:0000933 + MAT:0000163 + MIAA:0000163 + TGMA:0000540 + Wikipedia:Sensillum arthropod sensillum + + + + Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt]. + FBbt:00007152 + Wikipedia:Sensillum + @@ -115330,8 +176743,34 @@ + One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches. + AAO:0010359 + BTO:0001785 + EFO:0000959 + EHDAA:571 + EMAPA:16117 + FMA:293015 + GAID:1292 + MAT:0000242 + MESH:D001934 + MIAA:0000242 + NCIT:C34249 + SCTID:308766004 + TAO:0001306 + VHOG:0000155 + Wikipedia:Pharyngeal_arch + XAO:0000096 + ZFA:0001306 pharyngeal arch + + + + One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches. + PMID:16313389 + ZFA:yb + http://orcid.org/0000-0002-6601-2165 + @@ -115351,8 +176790,24 @@ + Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. + AAO:0010466 + EFO:0001650 + MAT:0000369 + MIAA:0000369 + XAO:0000305 cranial placode + + + + Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. + http://www.ncbi.nlm.nih.gov/books/NBK53175/ + https://github.com/obophenotype/uberon/issues/135 + https://github.com/seger/aao/issues/4 + https://orcid.org/0000-0002-6601-2165 + https://sourceforge.net/p/obo/xenopus-anatomy-xao-term-requests/11/ + @@ -115366,8 +176821,73 @@ + Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina. + BIRNLEX:1011 + FMA:67552 + MA:0002447 + NCIT:C34007 + galen:Cavity anatomical cavity + + + + Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina. + FMA:67552 + + + + + + + + + BIRNLEX:1019 + FMA:12237 + SCTID:362606005 + organ cavity + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube. + BIRNLEX:1029 + FMA:75007 + lumen of central nervous system + + + + + The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube. + https://orcid.org/0000-0002-6601-2165 + @@ -115399,8 +176919,19 @@ + Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. + BIRNLEX:1167 + FMA:55676 + NCIT:C13031 + SCTID:384763002 regional part of brain + + + + Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. + BIRNLEX:1167 + @@ -115431,9 +176962,21 @@ - + A spinal cord segment that adjacent_to a cervical region. + BIRNLEX:1499 + FMA:71166 + MA:0003081 + NCIT:C12892 + SCTID:180960003 + neuronames:1654 cervical spinal cord + + + + A spinal cord segment that adjacent_to a cervical region. + OBOL:automatic + @@ -115464,8 +177007,28 @@ + A nucleus of brain that is part of a trigeminal nuclear complex. + BM:V + BTO:0001074 + CALOHA:TS-2077 + EMAPA:35883 + EV:0100271 + FMA:71247 + GAID:604 + MA:0001028 + MESH:D014278 + NCIT:C12807 + SCTID:280164007 + VHOG:0001353 + http://uri.neuinfo.org/nif/nifstd/nifext_11 trigeminal nucleus + + + + A nucleus of brain that is part of a trigeminal nuclear complex. + OBOL:automatic + @@ -115504,9 +177067,22 @@ - + Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133). + BAMS:PTg + BIRNLEX:923 + DHBA:12416 + FMA:71108 + HBA:9135 + SCTID:362401009 + Wikipedia:Pontine_tegmentum pontine tegmentum + + + + Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133). + BIRNLEX:923 + @@ -115520,8 +177096,19 @@ + A wall, dividing a cavity or structure into smaller ones[WP]. + AAO:0011127 + FMA:86461 + Wikipedia:Septum + general anatomical term in FMA septum + + + + A wall, dividing a cavity or structure into smaller ones[WP]. + Wikipedia:Septum + @@ -115546,9 +177133,22 @@ - + The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]. + BIRNLEX:966 + FMA:71167 + MA:0003082 + NCIT:C12894 + SCTID:278750009 + Wikipedia:Thoracic_spinal_cord + neuronames:1718 thoracic spinal cord + + + + The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]. + Wikipedia:Thoracic_spinal_cord + @@ -115596,8 +177196,26 @@ + The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. + AAO:0011064 + DMBA:16810 + EHDAA2:0004395 + EHDAA:5789 + EMAPA:32857 + NCIT:C93172 + TAO:0000042 + VHOG:0000649 + XAO:0000016 + ZFA:0000042 + neuronames:2076 midbrain-hindbrain boundary + + + + The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. + GO:0021555 + @@ -115607,8 +177225,25 @@ + The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm. + EHDAA2:0001846 + EHDAA:6538 + FMA:295662 + NCIT:C34247 + TAO:0001185 + VHOG:0001680 + XAO:0000029 + ZFA:0001185 periderm + + + + The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm. + ISBN:9780878932504 + PMID:25133425 + PMID:35582825 + @@ -115629,8 +177264,20 @@ + The portion of neural plate anterior to the mid-hindbrain junction. + AAO:0011084 + TAO:0007016 + VHOG:0001200 + XAO:0000045 + ZFA:0007016 pre-chordal neural plate + + + + The portion of neural plate anterior to the mid-hindbrain junction. + XB:curator + @@ -115650,8 +177297,19 @@ + The portion of neural plate posterior to the mid-hindbrain junction. + TAO:0007017 + VHOG:0001201 + XAO:0000046 + ZFA:0007017 chordal neural plate + + + + The portion of neural plate posterior to the mid-hindbrain junction. + XB:curator + @@ -115692,8 +177350,23 @@ + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. + AAO:0011086 + EFO:0001982 + EMAPA:16189 + EMAPA:16752 + TAO:0000279 + VHOG:0000559 + XAO:0000057 + ZFA:0000279 presomitic mesoderm + + + + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. + ZFIN:curator + @@ -115713,8 +177386,25 @@ + Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. + AAO:0011006 + EFO:0003489 + EHDAA:207 + NCIT:C34113 + TAO:0000094 + TE:E5.11.2.0.0.0.4 + VHOG:0000085 + Wikipedia:Blood_island_of_umbilical_vesicle + XAO:0000067 + ZFA:0000094 blood island + + + + Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. + Wikipedia:Blood_island_of_umbilical_vesicle + @@ -115734,8 +177424,25 @@ + A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue. + AAO:0011085 + EHDAA2:0001493 + EHDAA:181 + FMA:295532 + TAO:0000060 + VHOG:0000086 + Wikipedia:Prechordal_plate + XAO:0000079 + ZFA:0000060 prechordal plate + + + + A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue. + ISBN:0838580343 + MP:0004387 + @@ -115773,8 +177480,27 @@ + The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. + AAO:0010575 + EMAPA:16056 + EMAPA:16178 + FMA:293147 + NCIT:C34193 + SCTID:361476001 + TAO:0001206 + VHOG:0000087 + Wikipedia:Intermediate_mesoderm + XAO:0000085 + ZFA:0001206 intermediate mesoderm + + + + The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. + GOC:curators + Wikipedia:Intermediate_mesoderm + @@ -115788,8 +177514,20 @@ + Lateral neurogenic placodes positioned dorsal of the epibranchial placodes. + TAO:0001310 + VHOG:0000103 + XAO:0000187 + ZFA:0001310 + The only remaining dorsolateral placode in land vertebrates is the otic/octaval placode dorsolateral placode + + + + Lateral neurogenic placodes positioned dorsal of the epibranchial placodes. + ZFIN:curator + @@ -115815,8 +177553,23 @@ + The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. + AAO:0011017 + EFO:0003647 + TAO:0001204 + VHOG:0000107 + Wikipedia:Chordamesoderm + XAO:0000205 + ZFA:0001204 axial mesoderm + + + + The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. + GO:0048318 + Wikipedia:Chordamesoderm + @@ -115830,8 +177583,23 @@ + A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion. + EFO:0003433 + EHDAA2:0004209 + TAO:0000162 + VHOG:0000109 + XAO:0000225 + ZFA:0000162 trigeminal placode complex + + + + A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion. + PMID:22512454 + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/693 + @@ -115872,8 +177640,23 @@ + Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles. + AAO:0011038 + EFO:0003541 + EHDAA2:0004431 + TAO:0000570 + XAO:0000227 + XAO:0004090 + ZFA:0000570 eye primordium + + + + Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles. + GO:0046619 + ZFA:0000570 + @@ -115900,8 +177683,26 @@ + Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]. + BTO:0005351 + EHDAA2:0001303 + EHDAA:2912 + EMAPA:16674 + NCIT:C34233 + SCTID:308789007 + TAO:0001202 + VHOG:0000167 + ZFA:0001202 optic cup + + + + Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]. + MP:0004269 + Wikipedia:Optic_cup_(embryology) + ZFA:0001202 + @@ -115941,8 +177742,28 @@ + A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]. + AAO:0011055 + EFO:0003494 + EHDAA2:0000982 + EHDAA:2908 + EMAPA:16672 + FMA:296767 + NCIT:C34202 + TAO:0000122 + VHOG:0000166 + Wikipedia:Lens_placode + XAO:0000240 + ZFA:0000122 lens placode + + + + A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]. + Wikipedia:Lens_placode + ZFIN:curator + @@ -115970,8 +177791,34 @@ + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. + AAO:0011072 + BTO:0001765 + DHBA:10153 + DMBA:15565 + EHDAA:346 + EHDAA:902 + EMAPA:35593 + FMA:293879 + NCIT:C34225 + RETIRED_EHDAA2:0001252 + TAO:0000132 + VHOG:0000068 + Wikipedia:Neural_plate + XAO:0000249 + ZFA:0000132 + neuronames:1362 neural plate + + + + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. + ISBN:0815318960 + OMD:neural+plate + Wikipedia:Neural_plate + ZFIN:curator + @@ -115991,6 +177838,11 @@ + AAO:0011082 + TAO:0007037 + VHOG:0001383 + XAO:0000250 + ZFA:0007037 posterior neural tube @@ -116020,8 +177872,28 @@ + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. + AAO:0010568 + EFO:0003515 + EMAPA:16183 + EMAPA:16751 + FMA:293145 + NCIT:C34244 + SCTID:361475002 + TAO:0000255 + VHOG:0000114 + Wikipedia:Paraxial_mesoderm + XAO:0000259 + ZFA:0000255 paraxial mesoderm + + + + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. + GO:0048339 + https://github.com/obophenotype/uberon/issues/30 + @@ -116047,8 +177919,22 @@ + Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia. + AAO:0011036 + EFO:0003455 + FMA:293968 + TAO:0001294 + VHOG:0000117 + XAO:0000284 + ZFA:0001294 epibranchial placode + + + + Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia. + VHOG:0000117 + @@ -116068,6 +177954,11 @@ + AAO:0011012 + TAO:0007038 + VHOG:0001384 + XAO:0000307 + ZFA:0007038 anterior neural tube @@ -116098,8 +177989,28 @@ + Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. + AAO:0010574 + EHDAA2:0000919 + EHDAA:379 + EMAPA:16179 + FMA:293149 + NCIT:C34199 + SCTID:361477005 + TAO:0000121 + VHOG:0000118 + Wikipedia:Lateral_plate_mesoderm + XAO:0000311 + ZFA:0000121 lateral plate mesoderm + + + + Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. + MP:0010117 + Wikipedia:Lateral_plate_mesoderm + @@ -116119,8 +178030,32 @@ + A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells. + AAO:0011067 + AEO:0001018 + BTO:0000742 + EHDAA2_RETIRED:0003431 + EHDAA:1721 + EHDAA:1727 + EHDAA:1733 + EHDAA:1739 + EMAPA:32841 + FMA:295658 + NCIT:C34214 + SCTID:344535001 + TAO:0001056 + VHOG:0001244 + Wikipedia:Myotome + XAO:0000315 + ZFA:0001056 myotome + + + + A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells. + AEO:0001018 + @@ -116142,8 +178077,24 @@ + Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]. + AAO:0010582 + EFO:0003605 + EHDAA2:0001901 + TAO:0001024 + VHOG:0000062 + Wikipedia:Trunk_neural_crest + XAO:0000319 + ZFA:0001024 trunk neural crest + + + + Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]. + ISBN:0815318960 + Wikipedia:Trunk_neural_crest + @@ -116175,8 +178126,73 @@ + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. + AAO:0011044 + BTO:0001887 + NCIT:C34276 + TAO:0000028 + XAO:0000336 + ZFA:0000028 heart primordium + + + + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Extension of the dorsal aorta in the tail. + AAO:0011023 + EFO:0003472 + TAO:0000011 + VHOG:0000123 + Wikipedia:Caudal_artery + XAO:0000364 + ZFA:0000011 + caudal artery + + + + + Extension of the dorsal aorta in the tail. + Wikipedia:Caudal_artery + ZFIN:curator + @@ -116197,8 +178213,28 @@ + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. + AAO:0010571 + AEO:0000212 + EHDAA2:0003439 + EMAPA:31159 + FMA:295652 + NCIT:C34287 + TAO:0001080 + VHOG:0000680 + Wikipedia:Sclerotome + XAO:0000397 + ZFA:0001080 sclerotome + + + + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. + Wikipedia:Sclerotome + XB:curator + https://github.com/obophenotype/uberon/issues/316 + @@ -116220,8 +178256,24 @@ + Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage. + AAO:0010580 + EFO:0003645 + EHDAA2:0004420 + EMAPA:16091 + TAO:0001194 + VHOG:0000063 + Wikipedia:Cranial_neural_crest + XAO:0001001 + ZFA:0001194 cranial neural crest + + + + Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage. + MGI:anna + @@ -116229,8 +178281,25 @@ + Gonochoristic organism that can produce female gametes. + AAO:0010030 + BILA:0000028 + CARO:0000028 + FMA:67812 + HAO:0000028 + SCTID:362608006 + TAO:0000303 + TGMA:0001839 + XAO:0003005 + ZFA:0000303 female organism + + + + Gonochoristic organism that can produce female gametes. + CARO:0000028 + @@ -116244,8 +178313,25 @@ + Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. + AAO:0010337 + AEO_RETIRED:0000010 + EHDAA2_RETIRED:0003010 + TAO:0000292 + VSAO:0000001 + Wikipedia:Surface_structure + XAO:0003028 + ZFA:0000292 + galen:SurfaceRegion surface structure + + + + Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/24 + @@ -116253,8 +178339,27 @@ + Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types. + AAO:0010015 + AEO:0000024 + BILA:0000024 + CARO:0000024 + EHDAA2:0003024 + HAO:0000024 + TADS:0000598 + TAO:0000496 + TGMA:0001837 + VHOG:0001723 + XAO:0003041 + ZFA:0000496 compound organ + + + + Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types. + CARO:0000024 + @@ -116291,8 +178396,63 @@ + Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme. + AAO:0010427 + AEO:0000145 + BTO:0001393 + CALOHA:TS-0620 + EHDAA2:0003145 + EV:0100007 + NCIT:C13301 + TAO:0000393 + VHOG:0000170 + Wikipedia:Mesenchyme + XAO:0003046 + ZFA:0000393 mesenchyme + + + + Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme. + https://archive.org/details/invertebratesnde00brus/page/n240/mode/2up + https://en.wikipedia.org/wiki/Mesenchyme + https://github.com/obophenotype/uberon/issues/1641 + + + + + + + + + + + + + + + + + + + + + Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ. + AAO:0010206 + EFO:0003525 + NCIT:C98765 + TAO:0000351 + XAO:0003172 + ZFA:0000351 + olfactory region + + + + + Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ. + TAO:0000351 + @@ -116312,8 +178472,22 @@ + Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]. + AAO:0010154 + TAO:0000863 + VHOG:0001665 + Wikipedia:Skull_roof + XAO:0003169 + ZFA:0000863 dermatocranium + + + + Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]. + Wikipedia:Skull_roof + ZFA:0000863 + @@ -116321,8 +178495,25 @@ + Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus. + AAO:0010366 + EHDAA2:0000086 + EHDAA:1663 + EMAPA:16760 + FMA:293035 + SCTID:308770007 + TAO:0001599 + VHOG:0000299 + XAO:0000449 + ZFA:0001607 pharyngeal arch 4 + + + + Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus. + MP:0006340 + @@ -116330,8 +178521,24 @@ + The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles. + AAO:0010368 + EHDAA2:0004075 + EMAPA:32766 + FMA:293047 + SCTID:308772004 + TAO:0001601 + VHOG:0001205 + XAO:0000453 + ZFA:0001609 pharyngeal arch 6 + + + + The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles. + MP:0006347 + @@ -116362,8 +178569,24 @@ + The vessels formed within the first pair of branchial arches in embryogenesis. + AAO:0010415 + EHDAA2:0000007 + EMAPA:16202 + EMAPA:16685 + SCTID:308774003 + TAO:0005005 + VHOG:0000149 + XAO:0000342 + ZFA:0005005 pharyngeal arch artery 1 + + + + The vessels formed within the first pair of branchial arches in embryogenesis. + MP:0010355 + @@ -116388,8 +178611,24 @@ + The vessels formed within the fourth pair of branchial arches in embryogenesis. + AAO:0010420 + EHDAA2:0000087 + EMAPA:17004 + SCTID:308777005 + TAO:0005008 + Wikipedia:Aortic_arches#Arch_4 + XAO:0000355 + ZFA:0005008 + proximal right subclavian pharyngeal arch artery 4 + + + + The vessels formed within the fourth pair of branchial arches in embryogenesis. + MP:0006354 + @@ -116414,8 +178653,24 @@ + The vessels formed within the sixth pair of branchial arches in embryogenesis. + AAO:0010422 + EHDAA2:0000102 + EMAPA:17005 + SCTID:308779008 + TAO:0005016 + VHOG:0000144 + Wikipedia:Aortic_arches#Arch_6 + XAO:0000353 + ZFA:0005016 pharyngeal arch artery 6 + + + + The vessels formed within the sixth pair of branchial arches in embryogenesis. + MP:0006355 + @@ -116453,9 +178708,35 @@ - + The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]. + AAO:0010140 + BTO:0001388 + CALOHA:TS-1060 + EFO:0000935 + EHDAA2:0002066 + EHDAA:3078 + EMAPA:16853 + EV:0100040 + FMA:7394 + GAID:361 + MA:0000441 + MAT:0000137 + MESH:D014132 + MIAA:0000137 + NCIT:C12428 + SCTID:181213009 + VHOG:0000371 + Wikipedia:Vertebrate_trachea + XAO:0000118 trachea + + + + The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]. + GO:0060438 + Wikipedia:Vertebrate_trachea + @@ -116463,9 +178744,26 @@ - + Upper portion of the skull that excludes the mandible (when present in the organism). + BTO:0001328 + EFO:0000831 + EHDAA:6029 + FMA:71325 + MA:0000316 + MAT:0000340 + MIAA:0000340 + SCTID:181889008 + VHOG:0000334 + Wikipedia:Cranium_(anatomy) cranium + + + + Upper portion of the skull that excludes the mandible (when present in the organism). + Wikipedia:Cranium_(anatomy) + http://orcid.org/0000-0002-6601-2165 + @@ -116504,8 +178802,29 @@ + Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]. + BTO:0001295 + CALOHA:TS-2344 + EHDAA2:0000325 + EMAPA:17680 + FMA:46565 + GAID:82 + MESH:D012886 + NCIT:C12789 + SCTID:110530005 + Wikipedia:Skull + WikipediaCategory:Skull + galen:Skull skull + + + + Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]. + PMID:11523816 + Wikipedia:Skull + http://sourceforge.net/tracker/?func=detail&aid=2962656&group_id=76834&atid=1205376 + @@ -116531,8 +178850,21 @@ + An organ involved in reproduction. + MA:0001752 + MESH:D005835 + NCIT:C25177 + SCTID:128181006 + TGMA:0000591 + WBbt:0008422 reproductive organ + + + + An organ involved in reproduction. + UBERON:xp + @@ -116557,8 +178889,17 @@ + A female organ involved in reproduction. + EMAPA:28540 + MA:0000544 female reproductive organ + + + + A female organ involved in reproduction. + UBERON:xp + @@ -116566,8 +178907,19 @@ + Organ part that has the form of a hollow cavity[WP]. + EFO:0002513 + FMA:82493 + NCIT:C12986 + Wikipedia:Alveolus alveolus + + + + Organ part that has the form of a hollow cavity[WP]. + Wikipedia:Alveolus + @@ -116592,8 +178944,51 @@ + Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]. ovary septum + + + + Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]. + GO:0080126 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a upper jaw [Automatically generated definition]. + EHDAA2:0002119 + EHDAA:8027 + EMAPA:18971 + epithelium of upper jaw + + + + + An epithelium that is part of a upper jaw [Automatically generated definition]. + OBOL:automatic + @@ -116618,8 +179013,19 @@ + An epithelium that is part of a lower jaw [Automatically generated definition]. + EHDAA2:0001019 + EHDAA:7999 + EMAPA:35516 + VHOG:0000802 epithelium of lower jaw + + + + An epithelium that is part of a lower jaw [Automatically generated definition]. + OBOL:automatic + @@ -116650,8 +179056,19 @@ + The portion of the yolk sac that is derived from endoderm and lines the yolk sac. + EHDAA2:0002215 + EHDAA:166 + EMAPA:16086 + VHOG:0000626 yolk sac endoderm + + + + The portion of the yolk sac that is derived from endoderm and lines the yolk sac. + UBERON:cjm + @@ -116676,8 +179093,89 @@ + An endoderm that is part of a foregut [Automatically generated definition]. + EHDAA2:0004568 + EHDAA:524 endoderm of foregut + + + + An endoderm that is part of a foregut [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm that is part of a midgut [Automatically generated definition]. + EHDAA:987 + EMAPA:16257 + RETIRED_EHDAA2:0001194 + VHOG:0001080 + endoderm of midgut + + + + + An endoderm that is part of a midgut [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm that is part of a hindgut [Automatically generated definition]. + EHDAA:979 + RETIRED_EHDAA2:0000781 + endoderm of hindgut + + + + + An endoderm that is part of a hindgut [Automatically generated definition]. + OBOL:automatic + @@ -116703,8 +179201,72 @@ + A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]. + EHDAA2:0000486 + EHDAA:2923 + EMAPA:17844 skeletal muscle tissue of eye + + + + A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones. + AAO:0000622 + EHDAA2:0002128 + EHDAA:8041 + EMAPA:17927 + FMA:54397 + MA:0001908 + VHOG:0000429 + XAO:0003087 + skeleton of upper jaw + + + + + A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones. + http://orcid.org/0000-0002-6601-2165 + @@ -116748,8 +179310,25 @@ + A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage. + AAO:0000274 + EHDAA2:0004606 + EHDAA:8005 + EMAPA:17910 + FMA:54398 + MA:0001906 + TAO:0001273 + VHOG:0000428 + XAO:0003084 + ZFA:0001273 skeleton of lower jaw + + + + A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage. + http://orcid.org/0000-0002-6601-2165 + @@ -116770,8 +179349,171 @@ + An endothelium that is part of a trachea. + EHDAA:3082 + RETIRED_EHDAA2:0002068 endothelium of trachea + + + + An endothelium that is part of a trachea. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. + EHDAA2:0001922 + EHDAA:2999 + EMAPA:17024 + MA:0001617 + SCTID:261623000 + VHOG:0000358 + mesentery of stomach + + + + + The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. + http://medical-dictionary.thefreedictionary.com/mesogastrium + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery that surrounds the heart. + EHDAA:432 + EMAPA:16212 + RETIRED_EHDAA2:0000739 + VHOG:0000353 + mesentery of heart + + + + + A mesentery that surrounds the heart. + MA:th + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a esophagus [Automatically generated definition]. + EHDAA2:0001288 + EHDAA:2943 + EMAPA:16836 + MA:0001569 + VHOG:0000415 + mesentery of oesophagus + + + + + A mesentery that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a midgut [Automatically generated definition]. + EHDAA2:0001202 + EHDAA:3031 + EMAPA:16721 + EMAPA:17039 + EMAPA:17197 + VHOG:0000413 + mesentery of midgut + + + + + A mesentery that is part of a midgut [Automatically generated definition]. + OBOL:automatic + @@ -116796,8 +179538,19 @@ + A gland that is part of a foregut [Automatically generated definition]. + EHDAA2:0000567 + EHDAA:950 + EMAPA:16557 + VHOG:0000650 gland of foregut + + + + A gland that is part of a foregut [Automatically generated definition]. + OBOL:automatic + @@ -116823,8 +179576,19 @@ + Racemose mucous glands beneath the mucous membrane of the pharynx. + BTO:0004849 + EHDAA2:0001461 + EHDAA:2967 + FMA:55075 pharyngeal gland + + + + Racemose mucous glands beneath the mucous membrane of the pharynx. + http://www.biology-online.org/dictionary/ + @@ -116849,8 +179613,19 @@ + A gland that is part of a integumental system [Automatically generated definition]. + EHDAA2:0000837 + EMAPA:17758 + MA:0000144 + VHOG:0000654 gland of integumental system + + + + A gland that is part of a integumental system [Automatically generated definition]. + OBOL:automatic + @@ -116884,8 +179659,17 @@ + A blood island that is part of a mesoderm. + EHDAA2:0003241 + EHDAA:170 mesoderm blood island + + + + A blood island that is part of a mesoderm. + OBOL:automatic + @@ -116917,8 +179701,19 @@ + Mesenchyme that is part of a developing camera-type eye. + EHDAA2:0000485 + EHDAA:2910 + EMAPA:16673 + VHOG:0001084 eye mesenchyme + + + + Mesenchyme that is part of a developing camera-type eye. + OBOL:automatic + @@ -116943,9 +179738,18 @@ - + Mesenchyme that is part of a developing ovary [Automatically generated definition]. + EHDAA2:0001362 + EHDAA:8128 + VHOG:0001441 mesenchyme of ovary + + + + Mesenchyme that is part of a developing ovary [Automatically generated definition]. + OBOL:automatic + @@ -116970,8 +179774,66 @@ + The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme. + EHDAA2:0002216 + EHDAA:168 + EHDAA:205 + EMAPA:16087 + EMAPA:16267 + VHOG:0000503 + VHOG:0000617 mesenchyme of yolk sac + + + + The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme. + UBERON:cjm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a developing upper jaw [Automatically generated definition]. + EHDAA2:0002124 + EHDAA:8031 + EMAPA:17929 + VHOG:0001099 + mesenchyme of upper jaw + + + + + Mesenchyme that is part of a developing upper jaw [Automatically generated definition]. + OBOL:automatic + @@ -117002,8 +179864,280 @@ + Mesenchyme that is part of a developing lower jaw [Automatically generated definition]. + EHDAA2:0001024 + EHDAA:8003 + EMAPA:17916 + VHOG:0001069 mesenchyme of lower jaw + + + + Mesenchyme that is part of a developing lower jaw [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of an anal canal [Automatically generated definition]. + EMAPA:27217 + EMAPA:27227 + EMAPA:27535 + FMA:85399 + SCTID:7892006 + submucosa of anal canal + + + + + A submucosa that is part of an anal canal [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + The submucous layer of the wall of the rectum. + BTO:0002114 + EMAPA:27083 + FMA:15034 + SCTID:71683001 + submucosa of rectum + + + + + The submucous layer of the wall of the rectum. + BTO:0002114 + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a colon [Automatically generated definition]. + EMAPA:27379 + FMA:14985 + MA:0003200 + SCTID:61647009 + submucosa of colon + + + + + A submucosa that is part of a colon [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a duodenum [Automatically generated definition]. + EMAPA:27027 + EMAPA:27097 + EMAPA:27239 + FMA:14943 + MA:0003213 + SCTID:76519004 + submucosa of duodenum + + + + + A submucosa that is part of a duodenum [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a rectum [Automatically generated definition]. + EMAPA:27087 + FMA:15039 + serosa of rectum + + + + + A serous membrane that is part of a rectum [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a colon [Automatically generated definition]. + EMAPA:27387 + FMA:14990 + MA:0003199 + SCTID:90132000 + serosa of colon + + + + + A serous membrane that is part of a colon [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a duodenum [Automatically generated definition]. + EMAPA:27247 + FMA:14948 + MA:0003212 + SCTID:1236009 + serosa of duodenum + + + + + A serous membrane that is part of a duodenum [Automatically generated definition]. + OBOL:automatic + @@ -117028,8 +180162,19 @@ + A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO). + BIRNLEX:2548 + BTO:0001123 + EMAPA:32814 + MA:0001161 ganglion of peripheral nervous system + + + + A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO). + BIRNLEX:2548 + @@ -117055,8 +180200,56 @@ + A ganglion that is part of a central nervous system [Automatically generated definition]. + EHDAA2:0000227 + EMAPA:16658 + FMA:83843 ganglion of central nervous system + + + + A ganglion that is part of a central nervous system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of an anal canal [Automatically generated definition]. + EMAPA:27531 + FMA:74654 + NCIT:C60784 + SCTID:362170004 + mucosa of anal canal + + + + + A mucosa that is part of an anal canal [Automatically generated definition]. + OBOL:automatic + @@ -117081,8 +180274,54 @@ + A mucosa that is part of a oral opening [Automatically generated definition]. + SCTID:362083000 mucosa of oral region + + + + A mucosa that is part of a oral opening [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a rectum [Automatically generated definition]. + CALOHA:TS-2107 + EMAPA:27081 + FMA:15033 + MA:0003218 + SCTID:362167003 + mucosa of rectum + + + + + A mucosa that is part of a rectum [Automatically generated definition]. + OBOL:automatic + @@ -117107,8 +180346,17 @@ + A layer of epithelial cells on the surface of the mucosa. + BTO:0003752 + lies on top of lamina propria epithelium of mucosa + + + + A layer of epithelial cells on the surface of the mucosa. + BTO:0003752 + @@ -117141,8 +180389,136 @@ + An epithelium that is part of a pharynx [Automatically generated definition]. + BSA:0000112 + BTO:0005240 + EMAPA:16708 + MA:0002725 + RETIRED_EHDAA2:0001460 + TAO:0001174 + XAO:0003202 + ZFA:0001174 pharyngeal epithelium + + + + An epithelium that is part of a pharynx [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a midgut. + BTO:0005053 + EHDAA2:0001195 + EMAPA:16569 + MA:0003205 + epithelium of midgut + + + + + An epithelium that is part of a midgut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a hindgut [Automatically generated definition]. + EHDAA2:0000782 + EMAPA:16717 + MA:0003206 + epithelium of hindgut + + + + + An epithelium that is part of a hindgut [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a rectum [Automatically generated definition]. + CALOHA:TS-2066 + EHDAA2:0001594 + EMAPA:17898 + FMA:17510 + MA:0003219 + VHOG:0001037 + epithelium of rectum + + + + + An epithelium that is part of a rectum [Automatically generated definition]. + OBOL:automatic + @@ -117167,8 +180543,17 @@ + An epithelium that is part of a right lung [Automatically generated definition]. + EMAPA:17663 + MA:0003132 epithelium of right lung + + + + An epithelium that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -117193,8 +180578,17 @@ + An epithelium that is part of a left lung [Automatically generated definition]. + EMAPA:17655 + MA:0003131 epithelium of left lung + + + + An epithelium that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -117239,8 +180633,18 @@ + An unilaminar epithelium that surrounds a pectoral appendage bud. + EHDAA2:0002134 + EMAPA:16407 + VHOG:0001047 pectoral appendage bud ectoderm + + + + An unilaminar epithelium that surrounds a pectoral appendage bud. + OBOL:automatic + @@ -117265,9 +180669,20 @@ - + A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]. + EHDAA2:0004155 + EMAPA:17326 + FMA:7282 + SCTID:362018002 + VHOG:0001227 cardiac muscle of right atrium + + + + A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]. + OBOL:automatic + @@ -117292,8 +180707,20 @@ + A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]. + EHDAA2:0004154 + EMAPA:17320 + FMA:7285 + SCTID:189936008 + VHOG:0001225 cardiac muscle of left atrium + + + + A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]. + OBOL:automatic + @@ -117318,8 +180745,18 @@ + A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. + EMAPA:17342 + FMA:83452 + VHOG:0001236 cardiac muscle of right ventricle + + + + A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. + OBOL:automatic + @@ -117344,8 +180781,18 @@ + A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. + EMAPA:17339 + FMA:83453 + VHOG:0001234 cardiac muscle of left ventricle + + + + A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. + OBOL:automatic + @@ -117365,9 +180812,19 @@ - + A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]. + EHDAA2:0004158 + EMAPA:17335 + FMA:84084 + VHOG:0000999 cardiac muscle tissue of interventricular septum + + + + A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]. + OBOL:automatic + @@ -117392,8 +180849,16 @@ + A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]. + EMAPA:18963 skeletal muscle tissue of pharynx + + + + A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]. + OBOL:automatic + @@ -117425,8 +180890,18 @@ + Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi. + EMAPA:18807 + MA:0001268 smooth muscle of eye + + + + Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi. + MGI:cwg + MP:0005247 + @@ -117457,9 +180932,20 @@ - + A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]. + BTO:0001391 + EMAPA:19192 + FMA:262010 + MA:0001863 + NCIT:C49306 smooth muscle of trachea + + + + A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]. + OBOL:automatic + @@ -117484,8 +180970,16 @@ + A mesothelium that is part of a pericardium [Automatically generated definition]. + RETIRED_EHDAA2:0001436 mesothelium of pericardial cavity + + + + A mesothelium that is part of a pericardium [Automatically generated definition]. + OBOL:automatic + @@ -117511,8 +181005,16 @@ + A mesothelium that is part of a diaphragm [Automatically generated definition]. + EMAPA:18429 mesothelium of diaphragm + + + + A mesothelium that is part of a diaphragm [Automatically generated definition]. + OBOL:automatic + @@ -117537,8 +181039,178 @@ + A mesothelium that is part of a pleural cavity [Automatically generated definition]. + BTO:0003155 + EHDAA2:0001476 + EMAPA:16775 + FMA:18148 mesothelium of pleural cavity + + + + A mesothelium that is part of a pleural cavity [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a urinary system [Automatically generated definition]. + EMAPA:17367 + MA:0003233 + mesentery of urinary system + + + + + A mesentery that is part of a urinary system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a hindgut [Automatically generated definition]. + EMAPA:16718 + mesentery of hindgut + + + + + A mesentery that is part of a hindgut [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a rectum [Automatically generated definition]. + EMAPA:18664 + mesentery of rectum + + + + + A mesentery that is part of a rectum [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a colon [Automatically generated definition]. + EMAPA:18942 + FMA:14645 + SCTID:245457004 + mesentery of colon + + + + + A mesentery that is part of a colon [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a duodenum [Automatically generated definition]. + EMAPA:19081 + mesentery of duodenum + + + + + A mesentery that is part of a duodenum [Automatically generated definition]. + OBOL:automatic + @@ -117563,8 +181235,17 @@ + A cartilage element that is part of a respiratory system [Automatically generated definition]. + EMAPA:18694 + MA:0001818 cartilage of respiratory system + + + + A cartilage element that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -117590,8 +181271,17 @@ + A gland that is part of a digestive tract [Automatically generated definition]. + EMAPA:18815 + MA:0003202 gland of digestive tract + + + + A gland that is part of a digestive tract [Automatically generated definition]. + OBOL:automatic + @@ -117622,8 +181312,20 @@ + Mesenchyme that is part of a pectoral appendage bud. + EHDAA2:0002135 + EHDAA:1703 + EMAPA:16408 + TAO:0000789 + ZFA:0000789 pectoral appendage bud mesenchyme + + + + Mesenchyme that is part of a pectoral appendage bud. + OBOL:automatic + @@ -117643,8 +181345,16 @@ + An adipose tissue that is part of a dermis [Automatically generated definition]. + MA:0000798 dermis adipose tissue + + + + An adipose tissue that is part of a dermis [Automatically generated definition]. + OBOL:automatic + @@ -117669,8 +181379,16 @@ + A nerve that is part of an abdomen [Automatically generated definition]. + MA:0000521 abdomen nerve + + + + A nerve that is part of an abdomen [Automatically generated definition]. + OBOL:automatic + @@ -117695,8 +181413,16 @@ + A nerve that is part of a neck [Automatically generated definition]. + MA:0000588 neck nerve + + + + A nerve that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -117721,8 +181447,17 @@ + Any nerve that innervates the iris. + EMAPA:35449 + MA:0001291 iris nerve + + + + Any nerve that innervates the iris. + UBERON:cjm + @@ -117747,8 +181482,16 @@ + A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk). + MA:0000515 nerve of trunk region + + + + A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk). + http://orcid.org/0000-0002-6601-2165 + @@ -117773,8 +181516,52 @@ + A nerve that is located in a thoracic cavity [Automatically generated definition]. + MA:0000556 thoracic cavity nerve + + + + A nerve that is located in a thoracic cavity [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition]. + EMAPA:36573 + FMA:84428 + MA:0002833 + trabecula carnea cardiac muscle tissue + + + + + A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition]. + OBOL:automatic + @@ -117799,8 +181586,19 @@ + A bone that is part of a head [Automatically generated definition]. + EMAPA:35996 + MA:0000576 + SCTID:118646007 + Different sources vary regarding which bones are craniofacial; e.g. hyoid bone head bone + + + + A bone that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -117825,8 +181623,16 @@ + A bone that is part of a neck [Automatically generated definition]. + MA:0000584 neck bone + + + + A bone that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -117852,8 +181658,21 @@ + A bone that is part of a facial skeleton [Automatically generated definition]. + EMAPA:19019 + EMAPA:35924 + MA:0001482 + MA:0003159 + NCIT:C63706 + SCTID:181799005 facial bone + + + + A bone that is part of a facial skeleton [Automatically generated definition]. + OBOL:automatic + @@ -117873,8 +181692,18 @@ + A bone that is part of a trunk [Automatically generated definition]. + EMAPA:36583 + MA:0000512 + SCTID:427358002 trunk bone + + + + A bone that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -117894,8 +181723,60 @@ + An artery that is part of a respiratory system [Automatically generated definition]. + MA:0001804 respiratory system artery + + + + An artery that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose. + FMA:49570 + MA:0001917 + SCTID:145137009 + Wikipedia:Superior_labial_artery + artery of upper lip + + + + + The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose. + Wikipedia:Superior_labial_artery + @@ -117927,9 +181808,19 @@ - + The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery. + FMA:49567 + MA:0001916 + SCTID:145036002 + Wikipedia:Inferior_labial_artery artery of lower lip + + + + The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery. + Wikipedia:Inferior_labial_artery + @@ -117949,8 +181840,17 @@ + An artery that is part of a thoracic cavity[cjm]. + MA:0001902 + MESH:D013895 thoracic cavity artery + + + + An artery that is part of a thoracic cavity[cjm]. + https://sourceforge.net/tracker/index.php?func=detail&aid=3317815&group_id=76834&atid=1205376 + @@ -117975,8 +181875,54 @@ + A vein that is part of a respiratory system [Automatically generated definition]. + MA:0001809 + MA:0001810 respiratory system venous blood vessel + + + + A vein that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + The inferior labial vein is the vein receiving blood from the upper lip. + FMA:52538 + MA:0002255 + SCTID:422755007 + Wikipedia:Superior_labial_vein + vein of upper lip + + + + + The inferior labial vein is the vein receiving blood from the upper lip. + Wikipedia:Superior_labial_vein + @@ -118001,9 +181947,19 @@ - + The inferior labial vein is the vein receiving blood from the lower lip. + FMA:52541 + MA:0002253 + SCTID:422955002 + Wikipedia:Inferior_labial_vein vein of lower lip + + + + The inferior labial vein is the vein receiving blood from the lower lip. + Wikipedia:Inferior_labial_vein + @@ -118023,8 +181979,49 @@ + A vein that is part of a thoracic cavity [Automatically generated definition]. + MA:0001903 thoracic cavity vein + + + + A vein that is part of a thoracic cavity [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A vein that is part of a tail [Automatically generated definition]. + AAO:0011105 + MA:0002233 + Wikipedia:Tail_vein + XAO:0000393 + tail vein + + + + + A vein that is part of a tail [Automatically generated definition]. + OBOL:automatic + Wikipedia:Tail_vein + @@ -118050,8 +182047,16 @@ + An endothelium of capillary that is part of a respiratory system [Automatically generated definition]. + MA:0001808 respiratory system capillary endothelium + + + + An endothelium of capillary that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118071,8 +182076,16 @@ + A venule that is part of a respiratory system [Automatically generated definition]. + MA:0001813 respiratory system venule + + + + A venule that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118098,8 +182111,16 @@ + An arteriole that is part of a respiratory system [Automatically generated definition]. + MA:0001803 respiratory system arteriole + + + + An arteriole that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118124,8 +182145,18 @@ + A blood vessel that is part of a head [Automatically generated definition]. + EMAPA:36610 + MA:0000575 + SCTID:127865000 head blood vessel + + + + A blood vessel that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -118150,8 +182181,16 @@ + A blood vessel that is part of an abdomen [Automatically generated definition]. + MA:0000518 abdomen blood vessel + + + + A blood vessel that is part of an abdomen [Automatically generated definition]. + OBOL:automatic + @@ -118177,8 +182216,17 @@ + A blood vessel that is part of a heart [Automatically generated definition]. + EMAPA:35397 + MA:0002483 heart blood vessel + + + + A blood vessel that is part of a heart [Automatically generated definition]. + OBOL:automatic + @@ -118204,8 +182252,17 @@ + A blood vessel that is part of a brain [Automatically generated definition]. + EMAPA:35182 + MA:0002769 brain blood vessel + + + + A blood vessel that is part of a brain [Automatically generated definition]. + OBOL:automatic + @@ -118231,8 +182288,18 @@ + A blood vessel that is part of a cornea [Automatically generated definition]. + EMAPA:36611 + MA:0001241 corneal blood vessel + + + + A blood vessel that is part of a cornea [Automatically generated definition]. + https://orcid.org/0000-0002-6601-2165 + https://sourceforge.net/tracker/index.php?func=detail&aid=3564332&group_id=36855&atid=440764 + @@ -118264,8 +182331,21 @@ + A blood vessel that is part of a retina [Automatically generated definition]. + EMAPA:36520 + GAID:509 + MA:0001317 + MESH:D012171 + SCTID:280692003 + XAO:0004153 retina blood vessel + + + + A blood vessel that is part of a retina [Automatically generated definition]. + OBOL:automatic + @@ -118290,8 +182370,16 @@ + A blood vessel that is part of a neck [Automatically generated definition]. + MA:0000583 neck blood vessel + + + + A blood vessel that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -118316,8 +182404,18 @@ + A blood vessel that is part of a respiratory system [Automatically generated definition]. + EMAPA:35731 + EMAPA:35995 + MA:0001799 respiratory system blood vessel + + + + A blood vessel that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118343,8 +182441,17 @@ + A blood vessel that is part of a trachea. + EMAPA:35874 + MA:0001852 trachea blood vessel + + + + A blood vessel that is part of a trachea. + OBOL:automatic + @@ -118369,8 +182476,18 @@ + A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta. + EMAPA:35144 + MA:0000061 + only in MA - supertype of artery, arteriole, aorta. arterial blood vessel + + + + A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta. + https://orcid.org/0000-0002-6601-2165 + @@ -118396,8 +182513,16 @@ + A blood vessel that is part of a iris [Automatically generated definition]. + MA:0001290 iris blood vessel + + + + A blood vessel that is part of a iris [Automatically generated definition]. + OBOL:automatic + @@ -118430,8 +182555,17 @@ + A blood vessel that is part of a lung [Automatically generated definition]. + EMAPA:32867 + MA:0002457 lung blood vessel + + + + A blood vessel that is part of a lung [Automatically generated definition]. + OBOL:automatic + @@ -118456,8 +182590,16 @@ + A blood vessel that is part of a trunk [Automatically generated definition]. + MA:0000511 trunk blood vessel + + + + A blood vessel that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -118482,8 +182624,51 @@ + A blood vessel that is part of a thoracic cavity [Automatically generated definition]. + MA:0000554 thoracic cavity blood vessel + + + + A blood vessel that is part of a thoracic cavity [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a tail [Automatically generated definition]. + EMAPA:35848 + MA:0000695 + tail blood vessel + + + + + A blood vessel that is part of a tail [Automatically generated definition]. + OBOL:automatic + @@ -118503,8 +182688,16 @@ + A capillary that is part of a respiratory system [Automatically generated definition]. + MA:0001807 respiratory system capillary + + + + A capillary that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118529,8 +182722,54 @@ + A gray matter that is part of a brain [Automatically generated definition]. + EMAPA:35184 + MA:0000810 + NCIT:C49333 brain gray matter + + + + A gray matter that is part of a brain [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a tail [Automatically generated definition]. + EMAPA:36502 + MA:0000700 + SCTID:67214004 + tail skin + + + + + A zone of skin that is part of a tail [Automatically generated definition]. + OBOL:automatic + @@ -118555,8 +182794,18 @@ + An alveolar duct that is part of a right lung [Automatically generated definition]. + EMAPA:35819 + MA:0001785 + NCIT:C49277 right lung alveolar duct + + + + An alveolar duct that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -118581,8 +182830,19 @@ + An alveolar duct that is part of a left lung [Automatically generated definition]. + EMAPA:19183 + MA:0001776 + NCIT:C49250 + Mice have 1 left lobe left lung alveolar duct + + + + An alveolar duct that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -118607,8 +182867,19 @@ + A bronchiole that is part of a right lung [Automatically generated definition]. + EMAPA:35425 + MA:0001787 + NCIT:C49279 + SCTID:200089000 right lung bronchiole + + + + A bronchiole that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -118633,8 +182904,19 @@ + A bronchiole that is part of a left lung [Automatically generated definition]. + EMAPA:19000 + MA:0001778 + NCIT:C49252 + SCTID:200484003 left lung bronchiole + + + + A bronchiole that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -118654,8 +182936,18 @@ + A terminal bronchiole that is part of a right lung [Automatically generated definition]. + EMAPA:36638 + MA:0001789 + NCIT:C49294 right lung terminal bronchiole + + + + A terminal bronchiole that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -118675,8 +182967,18 @@ + A terminal bronchiole that is part of a left lung [Automatically generated definition]. + EMAPA:36636 + MA:0001780 + NCIT:C49255 left lung terminal bronchiole + + + + A terminal bronchiole that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -118696,8 +182998,18 @@ + A respiratory bronchiole that is part of a right lung [Automatically generated definition]. + EMAPA:36637 + MA:0001788 + NCIT:C49285 right lung respiratory bronchiole + + + + A respiratory bronchiole that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -118717,8 +183029,18 @@ + A respiratory bronchiole that is part of a left lung [Automatically generated definition]. + EMAPA:36635 + MA:0001779 + NCIT:C49254 left lung respiratory bronchiole + + + + A respiratory bronchiole that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -118749,8 +183071,16 @@ + A portion of connective tissue that is part of a head [Automatically generated definition]. + MA:0000577 head connective tissue + + + + A portion of connective tissue that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -118775,8 +183105,16 @@ + A portion of connective tissue that is part of an abdomen [Automatically generated definition]. + MA:0000519 abdomen connective tissue + + + + A portion of connective tissue that is part of an abdomen [Automatically generated definition]. + OBOL:automatic + @@ -118801,8 +183139,16 @@ + A portion of connective tissue that is part of a neck [Automatically generated definition]. + MA:0000585 neck connective tissue + + + + A portion of connective tissue that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -118827,8 +183173,18 @@ + A portion of connective tissue that is part of a respiratory system [Automatically generated definition]. + EMAPA:35968 + EMAPA:35977 + MA:0001814 respiratory system connective tissue + + + + A portion of connective tissue that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118859,9 +183215,17 @@ - + A portion of connective tissue that is part of a trachea. + EMAPA:35876 + MA:0001853 trachea connective tissue + + + + A portion of connective tissue that is part of a trachea. + OBOL:automatic + @@ -118887,8 +183251,16 @@ + A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]. + MA:0002409 lower respiratory tract connective tissue + + + + A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]. + OBOL:automatic + @@ -118920,8 +183292,17 @@ + A portion of connective tissue that is part of a dermis [Automatically generated definition]. + EMAPA:36509 + MA:0000799 dermis connective tissue + + + + A portion of connective tissue that is part of a dermis [Automatically generated definition]. + OBOL:automatic + @@ -118946,8 +183327,16 @@ + A portion of connective tissue that is part of a trunk [Automatically generated definition]. + MA:0000513 trunk connective tissue + + + + A portion of connective tissue that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -118972,8 +183361,19 @@ + A portion of connective tissue that is part of a bronchus [Automatically generated definition]. + EMAPA:32690 + EMAPA:35193 + MA:0001831 + NCIT:C49210 bronchus connective tissue + + + + A portion of connective tissue that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -118998,8 +183398,51 @@ + A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]. + MA:0000555 thoracic cavity connective tissue + + + + A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a tail [Automatically generated definition]. + EMAPA:16749 + MA:0000697 + tail connective tissue + + + + + A portion of connective tissue that is part of a tail [Automatically generated definition]. + OBOL:automatic + @@ -119024,8 +183467,16 @@ + A cartilage that is part of a neck [Automatically generated definition]. + MA:0000586 neck cartilage + + + + A cartilage that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -119051,8 +183502,17 @@ + A cartilage that is part of a lower respiratory tract [Automatically generated definition]. + MA:0001819 + NCIT:C49256 lower respiratory tract cartilage + + + + A cartilage that is part of a lower respiratory tract [Automatically generated definition]. + OBOL:automatic + @@ -119083,9 +183543,25 @@ - + The ring-shaped cartilaginous structures that support the trachea. + EMAPA:18699 + EMAPA:35875 + FMA:7434 + MA:0001857 + NCIT:C49304 + SCTID:278979006 + Wikipedia:Tracheal_rings trachea cartilage + + + + The ring-shaped cartilaginous structures that support the trachea. + J:97123 + MGI:smb + MP:0003120 + http://orcid.org/0000-0002-6601-2165 + @@ -119112,8 +183588,16 @@ + A skin gland that is part of a camera-type eye [Automatically generated definition]. + MA:0002451 eye skin gland + + + + A skin gland that is part of a camera-type eye [Automatically generated definition]. + OBOL:automatic + @@ -119138,8 +183622,16 @@ + The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall. + MA:0002859 aorta elastic tissue + + + + The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall. + MP:0009862 + @@ -119166,8 +183658,16 @@ + The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers. + MA:0002858 heart elastic tissue + + + + The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers. + MP:0009863 + @@ -119193,8 +183693,16 @@ + An elastic tissue that is part of a respiratory system [Automatically generated definition]. + MA:0001820 respiratory system elastic tissue + + + + An elastic tissue that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -119219,8 +183727,16 @@ + An elastic tissue that is part of a circulatory system [Automatically generated definition]. + MA:0002857 cardiovascular system elastic tissue + + + + An elastic tissue that is part of a circulatory system [Automatically generated definition]. + OBOL:automatic + @@ -119246,8 +183762,18 @@ + Elastic tissue layer that lines a blood vessel layer. + EMAPA:36300 + MA:0002856 blood vessel elastic tissue + + + + Elastic tissue layer that lines a blood vessel layer. + http://orcid.org/0000-0002-6601-2165 + https://sourceforge.net/p/obo/mammalian-phenotype-requests/2026/ + @@ -119267,8 +183793,16 @@ + Elastic tissue that is part of a lung [Automatically generated definition]. + MA:0002860 lung elastic tissue + + + + Elastic tissue that is part of a lung [Automatically generated definition]. + OBOL:automatic + @@ -119294,8 +183828,17 @@ + An elastic tissue that is part of a bronchus [Automatically generated definition]. + MA:0001838 + NCIT:C49211 bronchus elastic tissue + + + + An elastic tissue that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -119321,9 +183864,16 @@ - + An elastic tissue that is part of a trachea [Automatically generated definition]. + MA:0001861 trachea elastic tissue + + + + An elastic tissue that is part of a trachea [Automatically generated definition]. + OBOL:automatic + @@ -119354,8 +183904,19 @@ + The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers. + EMAPA:35138 + FMA:74433 + MA:0002903 + SCTID:48467007 aorta tunica media + + + + The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers. + MP:0009873 + @@ -119387,8 +183948,20 @@ + The innermost layer of the aorta, containing the endothelium and an inner elastic membrane. + BTO:0005553 + EMAPA:35137 + FMA:74419 + MA:0002904 + SCTID:362031007 aorta tunica intima + + + + The innermost layer of the aorta, containing the endothelium and an inner elastic membrane. + MP:0009872 + @@ -119408,8 +183981,59 @@ + An arterial blood vessel that is part of a respiratory system [Automatically generated definition]. + MA:0001800 respiratory system arterial blood vessel + + + + An arterial blood vessel that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle organ that attaches to a tail vertebra [Automatically generated definition]. + AAO:0000081 + BTO:0001905 + MA:0000699 + SCTID:113230005 + post-anal tail muscle + + + + + A muscle organ that attaches to a tail vertebra [Automatically generated definition]. + OBOL:automatic + @@ -119444,8 +184068,25 @@ + The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity). + EFO:0000213 + EMAPA:36505 + FMA:12266 + GAID:17 + MA:0003057 + MESH:D034841 + NCIT:C12664 + SCTID:361294009 + Wikipedia:Abdominal_cavity + galen:AbdominalCavity abdominal cavity + + + + The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity). + UBERON:cjm + @@ -119476,8 +184117,80 @@ + In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]. + AAO:0010826 + FMA:75306 + GAID:228 + MESH:D005539 + NCIT:C12495 + SCTID:244679008 + TAO:0002045 + Wikipedia:Foramen_magnum + ZFA:0005387 + Design pattern notes: check whether this fits the foramen design pattern foramen magnum + + + + In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]. + Wikipedia:Foramen_magnum + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas. + FMA:25524 + GAID:250 + MESH:D001268 + NCIT:C32157 + SCTID:361832004 + Wikipedia:Atlanto-axial_joint + atlanto-axial joint + + + + + The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas. + Wikipedia:Atlanto-axial_joint + @@ -119502,8 +184215,91 @@ + The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles. + FMA:10429 + FMA:259054 + GAID:26 + MESH:D034861 + NCIT:C77608 + SCTID:181613000 + Wikipedia:Abdominal_wall abdominal wall + + + + The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles. + ncithesaurus:Abdominal_Wall + + + + + + + + + Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct. + FMA:14678 + GAID:281 + MA:0002659 + MESH:D017734 + NCIT:C32573 + SCTID:276158002 + extrahepatic bile duct + + + + + Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct. + MESH:A03.159.183.079 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct. + FMA:15766 + GAID:287 + MA:0001630 + MESH:D001653 + NCIT:C12677 + SCTID:362193005 + TAO:0005169 + ZFA:0005169 + intrahepatic bile duct + + + + + Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct. + MESH:A03.159.183.158 + @@ -119523,9 +184319,54 @@ - + The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava. + EHDAA2:0000182 + EHDAA:9868 + FMA:4723 + GAID:529 + MESH:D016121 + NCIT:C32816 + SCTID:181371003 + Wikipedia:Brachiocephalic_vein + galen:BrachiocephalicVein brachiocephalic vein + + + + The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava. + Wikipedia:Brachiocephalic_vein + + + + + + + + + + + + + + + A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein. + FMA:14331 + GAID:541 + MA:0002164 + MESH:D013162 + NCIT:C33608 + SCTID:278029005 + Wikipedia:Splenic_vein + galen:SplenicVein + splenic vein + + + + + A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein. + ncithesaurus:Splenic_Vein + @@ -119567,8 +184408,23 @@ + Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. + AAO:0000325 + AEO:0000123 + EHDAA2:0003123 + FMA:9642 + GAID:609 + MESH:D009417 + NCIT:C13052 + SCTID:91728009 neural tissue + + + + Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. + FMA:9642 + @@ -119599,9 +184455,21 @@ - + The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia. + BAMS:spn + FMA:5883 + GAID:800 + MESH:D013153 + SCTID:264198001 + Wikipedia:Splanchnic_nerves splanchnic nerve + + + + The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia. + MP:0008318 + @@ -119626,9 +184494,21 @@ - + The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls. + FMA:5860 + GAID:857 + MESH:D013900 + SCTID:360498003 + Wikipedia:Thoracic_nerves + neuronames:1725 thoracic nerve + + + + The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls. + MESH:A08.800.800.720.800 + @@ -119636,8 +184516,22 @@ + The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]. + EMAPA:18227 + FMA:6028 + GAID:858 + MESH:D007367 + NCIT:C32825 + SCTID:279568001 + Wikipedia:Intercostal_nerves intercostal nerve + + + + The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]. + Wikipedia:Intercostal_nerves + @@ -119686,8 +184580,24 @@ + A mucous membrane that lines the mouth. + BTO:0002860 + CALOHA:TS-0716 + EMAPA:26937 + FMA:59660 + GAID:951 + MA:0002794 + MESH:D009061 + NCIT:C77637 + Wikipedia:Oral_mucosa mouth mucosa + + + + A mucous membrane that lines the mouth. + http://orcid.org/0000-0002-6601-2165 + @@ -119712,8 +184622,18 @@ + A nerve that is part of a thorax [Automatically generated definition]. + MA:0000562 + MESH:D013900 + SCTID:359876006 nerve of thoracic segment + + + + A nerve that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -119738,8 +184658,16 @@ + A nerve that is part of an abdominal segment of trunk [Automatically generated definition]. + MA:0000528 nerve of abdominal segment + + + + A nerve that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -119759,8 +184687,17 @@ + A bone that is part of a thorax [Automatically generated definition]. + MA:0000559 + SCTID:426649006 thoracic segment bone + + + + A bone that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -119780,8 +184717,16 @@ + A bone that is part of an abdominal segment of trunk [Automatically generated definition]. + MA:0000525 abdominal segment bone + + + + A bone that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -119807,8 +184752,16 @@ + Any muscle organ that is part of a thorax [Automatically generated definition]. + MA:0000561 thoracic segment muscle + + + + Any muscle organ that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -119833,8 +184786,17 @@ + Any muscle organ that is part of a respiratory system [Automatically generated definition]. + EMAPA:35733 + MA:0001828 respiratory system muscle + + + + Any muscle organ that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -119861,8 +184823,18 @@ + Any muscle organ that is part of a esophagus [Automatically generated definition]. + EMAPA:26983 + MA:0002682 + SCTID:360961009 esophagus muscle + + + + Any muscle organ that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -119882,8 +184854,16 @@ + A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]. + MA:0000527 abdominal segment muscle + + + + A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -119908,8 +184888,16 @@ + A blood vessel that is part of a thorax [Automatically generated definition]. + MA:0000558 thoracic segment blood vessel + + + + A blood vessel that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -119934,8 +184922,16 @@ + A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]. + MA:0000524 abdominal segment blood vessel + + + + A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -119960,8 +184956,17 @@ + A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]. + FMA:264898 + MA:0000530 abdominal segment skin + + + + A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -119986,8 +184991,16 @@ + A portion of connective tissue that is part of a thorax [Automatically generated definition]. + MA:0000560 thoracic segment connective tissue + + + + A portion of connective tissue that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -120012,8 +185025,16 @@ + A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]. + MA:0000526 abdominal segment connective tissue + + + + A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -120044,8 +185065,22 @@ + An anatomical space that surrounded_by a neural tube. + AAO:0011073 + EHDAA2:0001269 + EHDAA:2889 + EHDAA:914 + EMAPA:16167 + VHOG:0001119 + XAO:0000252 neural tube lumen + + + + An anatomical space that surrounded_by a neural tube. + OBOL:automatic + @@ -120070,8 +185105,20 @@ + In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]. + EHDAA2:0000719 + EHDAA:8703 + SCTID:278192008 + VHOG:0001340 + Wikipedia:Gonadal_vein gonadal vein + + + + In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]. + Wikipedia:Gonadal_vein + @@ -120097,8 +185144,21 @@ + A neural crest that has_potential_to_developmentally_contribute_to a midbrain. + EFO:0003591 + EHDAA2:0001101 + EHDAA:360 + TAO:0000935 + VHOG:0000796 + ZFA:0000935 mesencephalic neural crest + + + + A neural crest that has_potential_to_developmentally_contribute_to a midbrain. + OBOL:automatic + @@ -120124,8 +185184,21 @@ + A neural crest that has_potential_to_developmentally_contribute_to a hindbrain. + EHDAA2:0001628 + EHDAA:362 + EMAPA:35747 + TAO:0007063 + VHOG:0001210 + ZFA:0007063 rhombencephalon neural crest + + + + A neural crest that has_potential_to_developmentally_contribute_to a hindbrain. + OBOL:automatic + @@ -120150,8 +185223,19 @@ + A neural crest that has_potential_to_developmentally_contribute_to a spinal cord. + EHDAA:696 + EMAPA:16163 + EMAPA:16881 + VHOG:0001006 spinal cord neural crest + + + + A neural crest that has_potential_to_developmentally_contribute_to a spinal cord. + OBOL:automatic + @@ -120176,8 +185260,19 @@ + A neural plate that develops_from a future spinal cord. + FMA:312957 + TAO:0007021 + VHOG:0000439 + ZFA:0007021 spinal cord neural plate + + + + A neural plate that develops_from a future spinal cord. + OBOL:automatic + @@ -120203,8 +185298,19 @@ + Mesenchyme that is part of a developing gonad [Automatically generated definition]. + EHDAA:5012 + EMAPA:16858 + EMAPA:17385 + VHOG:0001090 gonad mesenchyme + + + + Mesenchyme that is part of a developing gonad [Automatically generated definition]. + OBOL:automatic + @@ -120229,8 +185335,15 @@ + A presumptive structure that has the potential to develop into a ganglion. presumptive ganglion + + + + A presumptive structure that has the potential to develop into a ganglion. + OBOL:automatic + @@ -120273,8 +185386,15 @@ + An anatomical cavity that has the potential to develop into a coelemic cavity lumen. future coelemic cavity lumen + + + + An anatomical cavity that has the potential to develop into a coelemic cavity lumen. + OBOL:automatic + @@ -120294,8 +185414,21 @@ + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. + EHDAA:251 + EMAPA:16088 + NCIT:C34195 + VHOG:0000316 + Wikipedia:Intraembryonic_coelom intraembryonic coelom + + + + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. + MGI:anna + MP:0012187 + @@ -120315,8 +185448,77 @@ + Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma. + FMA:81494 + NCIT:C67387 stroma + + + + Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum. + AAO:0011058 + BTO:0003391 + EFO:0002577 + EFO:0003428 + EHDAA2:0000744 + EHDAA:973 + EMAPA:16847 + NCIT:C34277 + TAO:0000124 + XAO:0003266 + ZFA:0000124 + liver primordium + + + + + A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum. + ISBN:3211492755 + @@ -120347,8 +185549,16 @@ + A portion of skeletal muscle tissue in the trunk. + SCTID:244848007 skeletal muscle tissue of trunk + + + + A portion of skeletal muscle tissue in the trunk. + http://orcid.org/0000-0002-6601-2165 + @@ -120385,9 +185595,29 @@ - + The part of the retina that contains neurons and photoreceptor cells[GO]. + AAO:0011095 + BTO:0000929 + CALOHA:TS-0685 + EHDAA2:0001253 + EHDAA:4763 + EMAPA:17171 + EMAPA:18590 + FMA:58628 + MA:0000277 + NCIT:C33166 + TAO:0000046 + VHOG:0000535 + XAO:0003216 + ZFA:0000046 retinal neural layer + + + + The part of the retina that contains neurons and photoreceptor cells[GO]. + GO:0003407 + @@ -120395,8 +185625,20 @@ + Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]. + FMA:63131 + SCTID:340163004 + TAO:0005261 + Wikipedia:Sinusoid_(blood_vessel) + ZFA:0005261 sinusoid + + + + Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]. + Wikipedia:Sinusoid_(blood_vessel) + @@ -120416,8 +185658,18 @@ + Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + AEO:0000114 + EHDAA2:0003114 epithelial tube + + + + Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + GO:0060562 + PMID:12526790 + @@ -120437,8 +185689,15 @@ + Any endothelium that has the quality of being cylindrical [Automatically generated definition]. endothelial tube + + + + Any endothelium that has the quality of being cylindrical [Automatically generated definition]. + OBOL:automatic + @@ -120463,9 +185722,206 @@ - + A blood vessel that carries blood from the capillaries toward the heart. + EMAPA:35932 + FMA:86188 + MA:0000066 + Compare to: vein venous blood vessel + + + + A blood vessel that carries blood from the capillaries toward the heart. + http://www.thefreedictionary.com/venous+blood+vessel + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Embryonic structure that develops into pancreatic bud. + EFO:0002579 + EFO:0003434 + EHDAA2:0001382 + EHDAA:2163 + EMAPA:17066 + FMA:79792 + TAO:0000254 + XAO:0001101 + ZFA:0000254 + pancreas primordium + + + + + Embryonic structure that develops into pancreatic bud. + Wikipedia:Pancreas#Embryological_development + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]. + EFO:0003470 + EMAPA:35645 + NCIT:C34242 + SCTID:360398004 + TAO:0001390 + Wikipedia:Pancreatic_bud + ZFA:0001390 + pancreatic epithelial bud + + + + + The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]. + PMID:16417468 + Wikipedia:Pancreatic_bud + + + + + + + + + + + + + + + + + + + + + Pancreatic bud that gives rise to the accessory pancreatic duct. + AAO:0011031 + EFO:0003465 + EHDAA2:0001385 + EMAPA:17067 + SCTID:361435005 + TAO:0001370 + VHOG:0001428 + Wikipedia:Pancreatic_bud + XAO:0000467 + ZFA:0001370 + dorsal pancreatic bud + + + + + Pancreatic bud that gives rise to the accessory pancreatic duct. + Wikipedia:Pancreatic_bud + + + + + + + + + + + + + + + + + + + + + Pancreatic bud that gives rise to the major pancreatic duct. + AAO:0011111 + EFO:0003464 + EHDAA2:0001389 + EMAPA:17256 + SCTID:361437002 + TAO:0001369 + VHOG:0001429 + Wikipedia:Pancreatic_bud + XAO:0001103 + ZFA:0001369 + ventral pancreatic bud + + + + + Pancreatic bud that gives rise to the major pancreatic duct. + Wikipedia:Pancreatic_bud + @@ -120490,8 +185946,17 @@ + A duct that is part of a digestive system [Automatically generated definition]. + TAO:0005162 + ZFA:0005162 digestive system duct + + + + A duct that is part of a digestive system [Automatically generated definition]. + OBOL:automatic + @@ -120516,8 +185981,23 @@ + An epithelium that lines the lumen of the digestive tract. + BTO:0000956 + EHDAA2:0004567 + EMAPA:32928 + MA:0003201 + NCIT:C12963 + TAO:0005123 + XAO:0003200 + ZFA:0005123 digestive tract epithelium + + + + An epithelium that lines the lumen of the digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -120542,8 +186022,18 @@ + A cartilage element of chondrocranium. Example: neurocranial trabecula. + EFO:0003690 + TAO:0001461 + ZFA:0001461 cartilage element of chondrocranium + + + + A cartilage element of chondrocranium. Example: neurocranial trabecula. + https://orcid.org/0000-0002-6601-2165 + @@ -120568,8 +186058,18 @@ + A cartilage element that is part of the cranial skeleton. + TAO:0001458 + ZFA:0001458 cranial cartilage + + + + A cartilage element that is part of the cranial skeleton. + ZFA:0001458 + https://orcid.org/0000-0002-6601-2165 + @@ -120589,8 +186089,16 @@ + Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction. + MA:0001751 reproductive gland + + + + Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction. + MP:0000653 + @@ -120610,8 +186118,18 @@ + The sensory system for the sense of touch and pain. + NLXANAT:090818 + Wikipedia:Somatosensory_system + neuronames:2887 somatosensory system + + + + The sensory system for the sense of touch and pain. + NLXANAT:090818 + @@ -120649,9 +186167,15 @@ - + The anterior segment of the lamellated connective tissue layer of the cornea. anterior stroma of cornea + + + + The anterior segment of the lamellated connective tissue layer of the cornea. + MP:0003093 + @@ -120689,8 +186213,15 @@ + The posterior segment of the lamellated connective tissue layer of the cornea. posterior stroma of cornea + + + + The posterior segment of the lamellated connective tissue layer of the cornea. + MP:0003094 + @@ -120722,8 +186253,15 @@ + The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity. cutaneous elastic tissue + + + + The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity. + MP:0008418 + @@ -120743,9 +186281,19 @@ - + The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina. + BTO:0003099 + FMA:45654 + SCTID:303518005 + TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 internal female genitalia + + + + The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina. + MP:0009209 + @@ -120780,8 +186328,15 @@ + The connection between the embryo proper and extraembryonic tissues. embryonic-extraembryonic boundary + + + + The connection between the embryo proper and extraembryonic tissues. + MP:0003890 + @@ -120795,8 +186350,28 @@ + A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. + AAO:0011028 + AEO:0001017 + EHDAA2_RETIRED:0003428 + EHDAA:1719 + EHDAA:1725 + EHDAA:1731 + EHDAA:1737 + EMAPA:32838 + FMA:295656 + NCIT:C61572 + Wikipedia:Dermatome_(embryology) + XAO:0000220 dermatome + + + + A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. + AEO:0001017 + AEO:JB + @@ -120825,8 +186400,55 @@ + The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells. germinal neuroepithelium + + + + The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells. + MP:0004261 + http://www.ncbi.nlm.nih.gov/books/NBK10047 + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]. + BTO:0002840 + TAO:0005164 + ZFA:0005164 + biliary ductule + + + + + One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]. + BTO:0002840 + MP:0009494 + @@ -120854,8 +186476,20 @@ + The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium. + EMAPA:17152 + EMAPA:35362 + EMAPA_RETIRED:16783 + MA:0003193 neural tube ventricular layer + + + + The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium. + MP:0009689 + http://www.ncbi.nlm.nih.gov/books/NBK10047 + @@ -120889,8 +186523,19 @@ + The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. + EMAPA:17148 + EMAPA:35360 + neuronames:1367 neural tube mantle layer + + + + The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. + MP:0009690 + http://www.ncbi.nlm.nih.gov/books/NBK10047 + @@ -120917,8 +186562,18 @@ + The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter. + EMAPA:17151 + neuronames:1368 neural tube marginal layer + + + + The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter. + MP:0009691 + http://www.ncbi.nlm.nih.gov/books/NBK10047 + @@ -120957,8 +186612,94 @@ + The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons. + AAO:0010561 + EFO:0001904 + NCIT:C34111 + Wikipedia:Basal_plate_(neural_tube) + neuronames:1372 neural tube basal plate + + + + The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons. + MP:0009693 + Wikipedia:Basal_plate_(neural_tube) + http://www.ncbi.nlm.nih.gov/books/NBK10047 + + + + + + + + + + + + + + + The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout. + EHDAA2:0000578 + EHDAA:4778 + EMAPA:16681 + FMA:293101 + NCIT:C34182 + SCTID:361486000 + VHOG:0001319 + Wikipedia:Frontonasal_prominence + frontonasal prominence + + + + + The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout. + MP:0009901 + + + + + + + + + + + + + + + + + + + + + + + + + + + The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it. + EHDAA2:0001076 + EHDAA:4792 + EMAPA:16808 + FMA:295858 + SCTID:308877001 + VHOG:0000804 + Wikipedia:Medial_nasal_prominence + medial nasal prominence + + + + + The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it. + MP:0009903 + Wikipedia:Medial_nasal_prominence + @@ -120967,8 +186708,26 @@ + Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart. + AAO:0010215 + BTO:0001438 + EMAPA:18415 + FMA:321896 + GAID:547 + MA:0000068 + MESH:D014684 + NCIT:C12817 + SCTID:244405007 + Wikipedia:Venae_cavae vena cava + + + + Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart. + Wikipedia:Venae_cavae + http://orcid.org/0000-0002-6601-2165 + @@ -120982,8 +186741,53 @@ + The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present. + FMA:260119 orbital region + + + + The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + The middle of the face including the nose and its associated bony structures[MW]. + FMA:285406 + MA:0001910 + midface + + + + + The middle of the face including the nose and its associated bony structures[MW]. + HP:0000309 + http://www.merriam-webster.com/medical/midface + @@ -121025,11 +186829,20 @@ - - - + Any tube, opening or passage that connects two distinct anatomical spaces. + AEO:0000080 + EHDAA2:0003080 + FMA:242873 + SCTID:346902003 + Wikipedia:Foramen anatomical conduit + + + + Any tube, opening or passage that connects two distinct anatomical spaces. + http://orcid.org/0000-0002-6601-2165 + @@ -121054,8 +186867,16 @@ + A vasculature that is part of a iris [Automatically generated definition]. + ZFA:0005568 vasculature of iris + + + + A vasculature that is part of a iris [Automatically generated definition]. + OBOL:automatic + @@ -121080,8 +186901,15 @@ + An anatomical structure that develops (entirely or partially) from the endoderm. endoderm-derived structure + + + + An anatomical structure that develops (entirely or partially) from the endoderm. + https://orcid.org/0000-0002-6601-2165 + @@ -121106,8 +186934,15 @@ + An anatomical structure that develops (entirely or partially) from the mesoderm. mesoderm-derived structure + + + + An anatomical structure that develops (entirely or partially) from the mesoderm. + https://orcid.org/0000-0002-6601-2165 + @@ -121132,8 +186967,202 @@ + An anatomical structure that develops (entirely or partially) from the ectoderm. ectoderm-derived structure + + + + An anatomical structure that develops (entirely or partially) from the ectoderm. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction. + AAO:0000624 + BILA:0000122 + BTO:0003091 + EFO:0003864 + EHDAA:1013 + EMAPA:16367 + EV:0100094 + FMA:280610 + GAID:362 + MESH:D014566 + NCIT:C12810 + SCTID:278861008 + VHOG:0000286 + XAO:0000140 + galen:GenitoUrinarySystem + genitourinary system + + + + + Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction. + VHOG:0000286 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any of the layers of the myocardium. Example: compact layer, trabecular layer. + MA:0000080 + myocardial layer + + + + + Any of the layers of the myocardium. Example: compact layer, trabecular layer. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA]. + EFO:0003706 + MA:0002866 + TAO:0005059 + ZFA:0005059 + myocardium trabecular layer + + + + + The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA]. + ZFA:0005059 + + + + + + + + + + + + + + + + + + + + + + + + + + A myocardium trabecular layer that is part of a cardiac ventricle. + FMA:83511 + TAO:0005060 + ZFA:0005060 + trabecular layer of ventricle + + + + + A myocardium trabecular layer that is part of a cardiac ventricle. + OBOL:automatic + @@ -121166,8 +187195,28 @@ + The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]. + AAO:0011039 + EHDAA2:0001320 + EMAPA:16540 + FMA:293357 + NCIT:C34236 + SCTID:362864008 + TAO:0000050 + VHOG:0000165 + Wikipedia:Optic_vesicles + XAO:0000228 + ZFA:0000050 + Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 "Developmental Biology"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288] optic vesicle + + + + The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]. + GO:0003404 + Wikipedia:Optic_vesicles + @@ -121182,8 +187231,15 @@ + Missing definition for term UBERON:0004133. Please replace it using linked reference. salivatory nucleus + + + + Missing definition for term UBERON:0004133. Please replace it using linked reference. + GO:0021751 + @@ -121197,8 +187253,18 @@ + The first recognizable structure derived from the heart field. + EHDAA2:0000215 + EMAPA:16106 + VHOG:0000975 cardiogenic plate + + + + The first recognizable structure derived from the heart field. + GO:0003142 + @@ -121221,8 +187287,18 @@ + A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. + XAO:0004185 primary heart field + + + + A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. + GO:0003138 + GOC:mtg_heart + GOC:rl + @@ -121238,8 +187314,23 @@ + An epithelial tube that will give rise to the mature heart. + AAO:0010411 + EFO:0003526 + EMAPA:32685 + NCIT:C34161 + TAO:0000360 + XAO:0000337 + ZFA:0000360 heart tube + + + + An epithelial tube that will give rise to the mature heart. + GO:0003143 + GOC:mtg_heart + @@ -121264,8 +187355,16 @@ + The outflow tract septum is a partition in the outflow tract. + XAO:0004141 outflow tract septum + + + + The outflow tract septum is a partition in the outflow tract. + GO:0003148 + @@ -121298,8 +187397,22 @@ + The outflow tract is the portion of the heart through which blood flows into the arteries. + EHDAA2:0001351 + EHDAA:464 + EHDAA:798 + EMAPA:16346 + MA:0000100 + VHOG:0000670 + XAO:0004139 outflow tract + + + + The outflow tract is the portion of the heart through which blood flows into the arteries. + GO:0003151 + @@ -121320,8 +187433,16 @@ + The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. His-Purkinje system + + + + The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. + GO:0003164 + https://github.com/geneontology/go-ontology/issues/12451 + @@ -121352,8 +187473,23 @@ + Vein of heart that drains the myocardium. + EHDAA2:0004507 + FMA:12846 + NCIT:C12878 + NCIT:C12882 + SCTID:277726009 + Wikipedia:Coronary_circulation + ZFA:0005814 + galen:CoronaryVein cardiac vein + + + + Vein of heart that drains the myocardium. + http://orcid.org/0000-0002-6601-2165 + @@ -121368,8 +187504,18 @@ + A cardiac chamber surrounds an enclosed cavity within the heart. + FMA:7095 + SCTID:276456008 + generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus cardiac chamber + + + + A cardiac chamber surrounds an enclosed cavity within the heart. + GO:0003205 + @@ -121389,8 +187535,18 @@ + An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium. + EMAPA:36025 + ZFA:0005808 proepicardium + + + + An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium. + GO:0003342 + http://en.wiktionary.org/wiki/proepicardium + @@ -121410,8 +187566,24 @@ + A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]. + EHDAA2:0001829 + EHDAA:736 + EMAPA:16318 + FMA:295593 + NCIT:C34296 + SCTID:308819008 + VHOG:0000019 + Wikipedia:Septum_transversum septum transversum + + + + A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]. + VHOG:0000019 + Wikipedia:Septum_transversum + @@ -121419,9 +187591,17 @@ - + The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. + FMA:45652 + TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 internal genitalia + + + + The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. + GO:0035260 + @@ -121429,8 +187609,18 @@ + The external genitalia are the outer sex organs, such as the penis or vulva in mammals. + FMA:45643 + SCTID:362207005 + TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 external genitalia + + + + The external genitalia are the outer sex organs, such as the penis or vulva in mammals. + GO:0035261 + @@ -121456,8 +187646,19 @@ + Organ that is part of the hematopoietic system. + BTO:0004605 + FMA:7143 + MA:0000747 + SCTID:361338006 hemopoietic organ + + + + Organ that is part of the hematopoietic system. + GOC:Obol + @@ -121483,8 +187684,22 @@ + The nonstriated, involuntary muscle tissue located in the wall of the aorta. + BTO:0001685 + CALOHA:TS-0048 + EFO:0002775 + EMAPA:35135 + MA:0000702 + NCIT:C49191 aorta smooth muscle tissue + + + + The nonstriated, involuntary muscle tissue located in the wall of the aorta. + MGI:csmith + MP:0009865 + @@ -121508,8 +187723,16 @@ + A portions of the gut that is derived from endoderm. + EMAPA:32930 endodermal part of digestive tract + + + + A portions of the gut that is derived from endoderm. + GO:0061031 + @@ -121534,8 +187757,107 @@ + A nerve that is part of a back [Automatically generated definition]. + MA:0000497 back nerve + + + + A nerve that is part of a back [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]. + EMAPA:35469 + MA:0001547 + large intestine smooth muscle + + + + + A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]. + BTO:0000643 + EMAPA:35441 + EMAPA:35443 + MA:0001539 + NCIT:C49243 + intestine smooth muscle + + + + + A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]. + OBOL:automatic + @@ -121560,8 +187882,18 @@ + A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]. + BTO:0001818 + EMAPA:35823 + MA:0001627 stomach smooth muscle + + + + A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]. + OBOL:automatic + @@ -121586,8 +187918,18 @@ + A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]. + BTO:0001660 + EMAPA:35734 + MA:0001830 respiratory system smooth muscle + + + + A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -121612,8 +187954,51 @@ + A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]. + EMAPA:35117 + MA:0001523 gastrointestinal system smooth muscle + + + + A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]. + MA:0001532 + anal region smooth muscle + + + + + A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]. + OBOL:automatic + @@ -121639,8 +188024,17 @@ + A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]. + EMAPA:35520 + MA:0002410 lower respiratory tract smooth muscle + + + + A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]. + OBOL:automatic + @@ -121665,8 +188059,19 @@ + A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]. + BTO:0000655 + EMAPA:35448 + FMA:312338 + MA:0001270 iris smooth muscle + + + + A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]. + OBOL:automatic + @@ -121692,8 +188097,18 @@ + A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]. + EMAPA:36287 + FMA:312251 + MA:0000706 arteriole smooth muscle + + + + A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]. + OBOL:automatic + @@ -121718,9 +188133,137 @@ - + Smooth muscle found within, and composing the majority of the wall of blood vessels. + BTO:0001431 + CALOHA:TS-1107 + EMAPA:35177 + MA:0000710 + MESH:D009131 + NCIT:C33853 + TAO:0005321 + Wikipedia:Vascular_smooth_muscle + ZFA:0005321 blood vessel smooth muscle + + + + Smooth muscle found within, and composing the majority of the wall of blood vessels. + Wikipedia:Vascular_smooth_muscle + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]. + EMAPA:35807 + MA:0000757 + spleen smooth muscle + + + + + A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]. + EMAPA:35783 + MA:0001559 + small intestine smooth muscle + + + + + A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]. + EMAPA:35373 + MA:0001635 + NCIT:C49483 + gallbladder smooth muscle + + + + + A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]. + OBOL:automatic + @@ -121751,9 +188294,19 @@ - + A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]. + BTO:0004401 + EMAPA:35195 + MA:0001840 + NCIT:C49213 bronchus smooth muscle + + + + A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -121778,8 +188331,16 @@ + A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]. + MA:0000492 outflow tract smooth muscle + + + + A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]. + OBOL:automatic + @@ -121799,8 +188360,16 @@ + A bone that is part of the dorsal region of an animal. + MA:0000494 bone of dorsum + + + + A bone that is part of the dorsal region of an animal. + http://orcid.org/0000-0002-6601-2165 + @@ -121831,8 +188400,19 @@ + Any muscle organ that is part of a skin of body [Automatically generated definition]. + EMAPA:18187 + EMAPA:35776 + MA:0002710 + MA:0003139 skin muscle + + + + Any muscle organ that is part of a skin of body [Automatically generated definition]. + OBOL:automatic + @@ -121857,8 +188437,16 @@ + A blood vessel that is part of a back [Automatically generated definition]. + MA:0000493 back blood vessel + + + + A blood vessel that is part of a back [Automatically generated definition]. + OBOL:automatic + @@ -121883,8 +188471,19 @@ + A myocardium that is part of a outflow tract [Automatically generated definition]. + EHDAA2:0001358 + EMAPA:35623 + MA:0000489 + VHOG:0000603 outflow tract myocardium + + + + A myocardium that is part of a outflow tract [Automatically generated definition]. + OBOL:automatic + @@ -121909,8 +188508,16 @@ + A portion of connective tissue that is part of a back [Automatically generated definition]. + MA:0000495 back connective tissue + + + + A portion of connective tissue that is part of a back [Automatically generated definition]. + OBOL:automatic + @@ -121936,8 +188543,16 @@ + A pericardium that is part of a outflow tract [Automatically generated definition]. + MA:0000491 outflow tract pericardium + + + + A pericardium that is part of a outflow tract [Automatically generated definition]. + OBOL:automatic + @@ -121969,8 +188584,18 @@ + A muscle that is part of the eye region. + AAO:0000156 + EMAPA:35335 + MA:0000271 eye muscle + + + + A muscle that is part of the eye region. + OBOL:automatic + @@ -121991,9 +188616,30 @@ - + Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. + AEO:0000168 + EHDAA2:0001843 + EHDAA:5047 + EMAPA:17213 + FMA:23875 + GAID:177 + MA:0003006 + MAT:0000032 + MESH:D012863 + MIAA:0000032 + SCTID:361378004 + VSAO:0000026 + Wikipedia:Skeleton + XAO:0004053 + galen:Skeleton skeleton + + + + Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. + VSAO:0000026 + @@ -122014,8 +188660,24 @@ + The bilaminar epithelium formed from the myotome and dermatome. + AAO:0010572 + AEO:0000214 + EHDAA2:0003259 + EMAPA:31109 + FMA:295654 + NCIT:C34140 + TAO:0001513 + VHOG:0000676 + ZFA:0001513 dermomyotome + + + + The bilaminar epithelium formed from the myotome and dermatome. + AEO:0000214 + @@ -122029,8 +188691,17 @@ + A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. + TAO:0000115 + ZFA:0000115 heart rudiment + + + + A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. + GO:0003313 + @@ -122057,8 +188728,19 @@ + Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart. + EMAPA:36645 + FMA:9496 + Wikipedia:Cardiac_skeleton cardiac skeleton + + + + Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart. + GO:0003204 + Wikipedia:Cardiac_skeleton + @@ -122084,8 +188766,16 @@ + A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]. + MA:0001806 respiratory system blood vessel smooth muscle + + + + A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -122112,8 +188802,20 @@ + Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition. + BTO:0001840 + EHDAA2:0002091 + EHDAA:56 + EMAPA:16046 + VHOG:0000979 trophectoderm + + + + Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition. + MP:0005028 + @@ -122127,8 +188829,19 @@ + The embryonic structure that gives rise to the corneal ectoderm. + EHDAA:938 + EMAPA:16322 + RETIRED_EHDAA2:0001308 + VHOG:0001296 optic eminence + + + + The embryonic structure that gives rise to the corneal ectoderm. + MP:0006305 + @@ -122172,8 +188885,23 @@ + Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. + AAO:0010760 + EMAPA:32744 + NCIT:C34109 + TAO:0002146 + Wikipedia:Apical_ectodermal_ridge + XAO:0004121 + ZFA:0001702 apical ectodermal ridge + + + + Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. + MP:0001676 + Wikipedia:Apical_ectodermal_ridge + @@ -122200,8 +188928,19 @@ + An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. + VHOG:0001258 + Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056] paired limb/fin bud + + + + An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. + ISBN:9780878932504 + MP:0005650 + https://orcid.org/0000-0002-6601-2165 + @@ -122209,8 +188948,29 @@ + The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries. + AAO:0010364 + CALOHA:TS-2089 + EHDAA2:0000006 + EHDAA:573 + EMAPA:16118 + FMA:293019 + MFMO:0000095 + NCIT:C34175 + SCTID:308767008 + TAO:0001595 + VHOG:0000296 + Wikipedia:First_pharyngeal_arch + XAO:0000097 + ZFA:0001612 pharyngeal arch 1 + + + + The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries. + http://orcid.org/0000-0002-6601-2165 + @@ -122245,8 +189005,27 @@ + One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]. + AAO:0010414 + EFO:0003695 + EHDAA2:0000186 + EHDAA:398 + EHDAA:7327 + EMAPA:16684 + NCIT:C32123 + TAO:0005004 + VHOG:0000122 + Wikipedia:Aortic_arches + XAO:0000341 + ZFA:0005004 pharyngeal arch artery + + + + One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]. + MP:0002672 + @@ -122260,8 +189039,18 @@ + Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta. + BTO:0001715 + EMAPA:16059 ectoplacental cone + + + + Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta. + MP:0001717 + PMID:19829370 + @@ -122292,8 +189081,16 @@ + Blood vessel that is connected to the yolk sac. + EMAPA:36494 vitelline blood vessel + + + + Blood vessel that is connected to the yolk sac. + http://orcid.org/0000-0002-6601-2165 + @@ -122351,8 +189148,27 @@ + A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]. + EMAPA:18804 + FMA:58309 + GAID:894 + MA:0001246 + MESH:D003886 + NCIT:C32454 + SCTID:281076002 + TAO:0002157 + Wikipedia:Descemet%27s_membrane + ZFA:0001686 + The strong, resistant, thin, noncellular fourth layer of the cornea, located between the endothelium (from which it is secreted) and the stroma. (Cline et al., Dictionary of Visual Science, 4th ed) Descemet's membrane + + + + A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]. + MP:0004285 + https://github.com/obophenotype/uberon/issues/15 + @@ -122388,8 +189204,22 @@ + A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane. + FMA:58273 + MA:0001240 + NCIT:C32226 + SCTID:281075003 + TAO:0002155 + Wikipedia:Bowman%27s_membrane + ZFA:0001684 anterior limiting lamina of cornea + + + + A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane. + ncithesaurus:Bowman_s_Membrane + @@ -122414,8 +189244,16 @@ + Vascular network that is connected to the yolk sac. + Wikipedia:Vitelline_circulation vitelline vasculature + + + + Vascular network that is connected to the yolk sac. + http://orcid.org/0000-0002-6601-2165 + @@ -122441,8 +189279,58 @@ + A bone that is part of an appendage [Automatically generated definition]. bone of free limb or fin + + + + A bone that is part of an appendage [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra. + MA:0002869 + XAO:0003077 + trunk or cervical vertebra + + + + + A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra. + UBERONREF:0000006 + @@ -122473,8 +189361,18 @@ + An embryo at the neurula stage. + BILA:0000061 + BTO:0001766 + NCIT:C34229 neurula embryo + + + + An embryo at the neurula stage. + http://orcid.org/0000-0002-6601-2165 + @@ -122495,8 +189393,16 @@ + Sum of all sensory systems in an organism. + FMA:78499 entire sense organ system + + + + Sum of all sensory systems in an organism. + http://orcid.org/0000-0002-6601-2165 + @@ -122543,8 +189449,18 @@ + Any collection of skeletal muscles that is part of a head [Automatically generated definition]. + EMAPA:18171 + FMA:71287 + This class is restricted to skeletal muscles that attach to the cranial skeleton. This seems to be consistent with FMA and EMAPA usage. Note that by definition this excludes invertebrate head musculature. It corresponds to the individual muscle organ term UBERON:0002376 skeletal musculature of head + + + + Any collection of skeletal muscles that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -122569,8 +189485,17 @@ + Any collection of muscles that is part of a thorax [Automatically generated definition]. + BTO:0000508 + FMA:71293 musculature of thorax + + + + Any collection of muscles that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -122595,8 +189520,46 @@ + Any collection of muscles that is part of a neck [Automatically generated definition]. + AAO:0000091 + EMAPA:36050 + FMA:71290 + MESH:D009334 musculature of neck + + + + Any collection of muscles that is part of a neck [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:33061 + set of muscles of vertebral column + @@ -122621,8 +189584,16 @@ + Any collection of muscles that is part of a back [Automatically generated definition]. + FMA:71291 musculature of back + + + + Any collection of muscles that is part of a back [Automatically generated definition]. + OBOL:automatic + @@ -122647,8 +189618,17 @@ + A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles. + AAO:0000423 + FMA:33519 musculature of pectoral girdle + + + + A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles. + https://orcid.org/0000-0002-6601-2165 + @@ -122673,8 +189653,16 @@ + Any collection of muscles that is part of a face. + FMA:71288 musculature of face + + + + Any collection of muscles that is part of a face. + OBOL:automatic + @@ -122699,8 +189687,18 @@ + Any collection of muscles that is part of a trunk [Automatically generated definition]. + AAO:0011572 + EFO:0003531 + FMA:50187 musculature of trunk + + + + Any collection of muscles that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -122725,8 +189723,16 @@ + A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]. + FMA:7283 cardiac muscle tissue of atrium + + + + A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]. + OBOL:automatic + @@ -122751,8 +189757,16 @@ + A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]. + FMA:84083 cardiac muscle tissue of interatrial septum + + + + A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]. + OBOL:automatic + @@ -122777,8 +189791,16 @@ + A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]. + FMA:226279 cardiac muscle tissue of cardiac septum + + + + A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]. + OBOL:automatic + @@ -122803,8 +189825,17 @@ + A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]. + FMA:261726 + MA:0002441 cardiac muscle tissue of myocardium + + + + A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]. + OBOL:automatic + @@ -122830,8 +189861,16 @@ + A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition]. + FMA:261898 skeletal muscle tissue of diaphragm + + + + A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition]. + OBOL:automatic + @@ -122856,9 +189895,16 @@ - + A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]. + FMA:261045 smooth muscle tissue of bronchiole + + + + A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -122889,9 +189935,16 @@ - + A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]. + FMA:261051 smooth muscle tissue of terminal bronchiole + + + + A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -122922,9 +189975,50 @@ - + A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition]. + FMA:261055 smooth muscle tissue of respiratory bronchiole + + + + A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle that is attached to a vertebra of the vertebral column. + FMA:22594 + muscle of vertebral column + + + + + A muscle that is attached to a vertebra of the vertebral column. + https://orcid.org/0000-0002-6601-2165 + @@ -122949,8 +190043,16 @@ + A vasculature that is part of a muscle organ [Automatically generated definition]. + FMA:87123 vasculature of muscle organ + + + + A vasculature that is part of a muscle organ [Automatically generated definition]. + OBOL:automatic + @@ -122975,8 +190077,86 @@ + A vasculature that is part of a musculoskeletal system [Automatically generated definition]. + FMA:239607 vasculature of musculoskeletal system + + + + A vasculature that is part of a musculoskeletal system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. + FMA:84429 + cardiac muscle tissue of trabecula carnea of right ventricle + + + + + A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. + FMA:84430 + cardiac muscle tissue of trabecula carnea of left ventricle + + + + + A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. + OBOL:automatic + @@ -123021,9 +190201,37 @@ - + Anatomical system that has as its parts the heart and blood vessels. + AAO:0011001 + BILA:0000016 + BTO:0000088 + CALOHA:TS-1297 + EFO:0000791 + EHDAA:394 + EMAPA:16104 + EV:0100017 + FMA:7161 + GAID:467 + MA:0000010 + MAT:0000016 + MESH:D002319 + MIAA:0000016 + NCIT:C12686 + SCTID:278198007 + TAO:0000010 + VHOG:0000302 + WikipediaCategory:Cardiovascular_system + XAO:0000100 + XAO:0001010 + ZFA:0000010 cardiovascular system + + + + Anatomical system that has as its parts the heart and blood vessels. + BTO:0000088 + @@ -123048,9 +190256,17 @@ - + A vascular network consisting of blood vessels. + TAO:0001079 + ZFA:0001079 blood vasculature + + + + A vascular network consisting of blood vessels. + https://orcid.org/0000-0002-6601-2165 + @@ -123076,8 +190292,19 @@ + An eye that is part of a left side of organism [Automatically generated definition]. + FMA:12515 + MA:0002949 + NCIT:C119334 + SCTID:362503005 left eye + + + + An eye that is part of a left side of organism [Automatically generated definition]. + OBOL:automatic + @@ -123103,8 +190330,19 @@ + An eye that is part of a right side of organism [Automatically generated definition]. + FMA:12514 + MA:0002950 + NCIT:C119333 + SCTID:362502000 right eye + + + + An eye that is part of a right side of organism [Automatically generated definition]. + OBOL:automatic + @@ -123118,8 +190356,18 @@ + The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart. + FMA:45623 + Wikipedia:Systemic_circulation#Arteries systemic arterial system + + + + The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart. + Wikipedia:Systemic_circulation#Arteries + http://orcid.org/0000-0002-6601-2165 + @@ -123133,9 +190381,23 @@ - + The part of the cardiovascular system consisting of all arteries. + BTO:0004690 + EHDAA2:0000143 + EHDAA:396 + EMAPA:16201 + EMAPA:16371 + MA:0002719 + SCTID:362030008 + VHOG:0000273 arterial system + + + + The part of the cardiovascular system consisting of all arteries. + https://orcid.org/0000-0002-6601-2165 + @@ -123160,9 +190422,18 @@ - + An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart. + FMA:66464 + Wikipedia:Artery#Systemic_arteries systemic artery + + + + An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart. + Wikipedia:Artery#Systemic_arteries + http://orcid.org/0000-0002-6601-2165 + @@ -123176,8 +190447,18 @@ + The part of the venous system that drains the general body tissues[Kardong]. + FMA:45626 + Wikipedia:Systemic_venous_system systemic venous system + + + + The part of the venous system that drains the general body tissues[Kardong]. + ISBN:0073040584 + Wikipedia:Systemic_venous_system + @@ -123191,9 +190472,42 @@ - + The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions. + BTO:0004692 + EHDAA2:0002171 + EHDAA:486 + EMAPA:16240 + MA:0002720 + NCIT:C33858 + SCTID:362060003 + VHOG:0000277 venous system + + + + The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. + FMA:75004 + NCIT:C28381 + Wikipedia:Sphincter + sphincter muscle + + + + + A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. + Wikipedia:Sphincter + @@ -123218,9 +190532,64 @@ - + An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart. + BTO:0000766 + CALOHA:TS-2155 + EMAPA:35176 + MA:0000709 + NCIT:C53395 + TAO:0005257 + ZFA:0005257 blood vessel endothelium + + + + An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein. + EMAPA:35499 + FMA:14471 + MA:0002494 + NCIT:C32732 + SCTID:362194004 + Wikipedia:Lobules_of_liver + liver lobule + + + + + The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein. + ISBN:0-683-40008-8 + MP:0008987 + @@ -123251,8 +190620,18 @@ + An anatomical wall that is part of an aorta, enclosing the luminal space. + EMAPA:35139 + FMA:14156 + MA:0002901 aorta wall + + + + An anatomical wall that is part of an aorta, enclosing the luminal space. + http://orcid.org/0000-0002-6601-2165 + @@ -123283,8 +190662,20 @@ + The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers. + EMAPA:35136 + FMA:14283 + MA:0002902 + SCTID:24996002 aorta tunica adventitia + + + + The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers. + ISBN:0-683-40008-8 + MP:0009871 + @@ -123323,8 +190714,21 @@ + The membranous portion of the wall between the two lower chambers of the heart. + EHDAA2:0004596 + EMAPA:18246 + FMA:7135 + MA:0002939 + SCTID:278228007 + VHOG:0000927 interventricular septum membranous part + + + + The membranous portion of the wall between the two lower chambers of the heart. + MP:0008823 + @@ -123355,8 +190759,22 @@ + The muscular portion of the wall between the two lower chambers of the heart. + EHDAA2:0000885 + EHDAA:2607 + EMAPA:18247 + FMA:7134 + MA:0002940 + RETIRED_EHDAA2:0000888 interventricular septum muscular part + + + + The muscular portion of the wall between the two lower chambers of the heart. + Wikipedia:Interventricular_septum#Portions + http://orcid.org/0000-0002-6601-2165 + @@ -123376,8 +190794,28 @@ + The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane. + BAMS:RA + EMAPA:35721 + FMA:84017 + MA:0003147 + MESH:D011903 + NCIT:C97335 + NLXANAT:20090205 + TAO:0001429 + Wikipedia:Raphe_nuclei + ZFA:0001429 + neuronames:2495 + we treat NR obscurus, NR magnus etc as parts of the raphe nuclei. This is consistent with treatment in FMA, where the class is 'set of raphe nuclei' raphe nuclei + + + + The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane. + NLXANAT:20090205 + https://sourceforge.net/tracker/?func=detail&aid=3248146&group_id=36855&atid=440764 + @@ -123391,9 +190829,19 @@ - + The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]. + FMA:10636 + MA:0001939 + SCTID:244225009 + Wikipedia:Costocervical_trunk costo-cervical trunk + + + + The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]. + Wikipedia:Costocervical_trunk + @@ -123418,8 +190866,17 @@ + A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]. + EMAPA:36503 + MA:0000704 arterial system smooth muscle + + + + A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]. + OBOL:automatic + @@ -123450,8 +190907,17 @@ + A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]. + EMAPA:36613 + MA:0000715 venous system smooth muscle + + + + A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]. + OBOL:automatic + @@ -123476,8 +190942,17 @@ + An endothelium that is part of a vena cava [Automatically generated definition]. + MA:0000713 + NCIT:C49318 vena cava endothelium + + + + An endothelium that is part of a vena cava [Automatically generated definition]. + OBOL:automatic + @@ -123502,8 +190977,17 @@ + An endothelium that is part of a outflow tract [Automatically generated definition]. + MA:0000490 + VHOG:0001524 outflow tract endothelium + + + + An endothelium that is part of a outflow tract [Automatically generated definition]. + OBOL:automatic + @@ -123528,8 +191012,18 @@ + An endothelium that is part of an arterial system [Automatically generated definition]. + EMAPA:35145 + MA:0000703 + NCIT:C49329 arterial system endothelium + + + + An endothelium that is part of an arterial system [Automatically generated definition]. + OBOL:automatic + @@ -123554,8 +191048,18 @@ + An endothelium that is part of a venous system [Automatically generated definition]. + EMAPA:35907 + MA:0000714 + NCIT:C49320 venous system endothelium + + + + An endothelium that is part of a venous system [Automatically generated definition]. + OBOL:automatic + @@ -123581,8 +191085,17 @@ + A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]. + EMAPA:35732 + MA:0001805 respiratory system blood vessel endothelium + + + + A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -123596,8 +191109,24 @@ + A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches. + EHDAA2:0000197 + EHDAA:438 + EHDAA:768 + EMAPA:16333 + FMA:70300 + NCIT:C34114 + SCTID:361525002 + Wikipedia:Bulbus_cordis bulbus cordis + + + + A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches. + ISBN:0-683-40008-8 + MP:0010568 + @@ -123664,8 +191193,17 @@ + An appendage that is part of an appendage girdle complex. + VSAO:0000067 paired limb/fin + + + + An appendage that is part of an appendage girdle complex. + UBERON:cjm + https://github.com/geneontology/go-ontology/issues/9029 + @@ -123708,8 +191246,17 @@ + Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues. + VHOG:0001753 + VSAO:0000125 pectoral appendage + + + + Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues. + VSAO:0000150-modified + @@ -123723,8 +191270,24 @@ + The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava. + BTO:0001744 + CALOHA:TS-0497 + EMAPA:18638 + GAID:536 + MA:0002154 + MESH:D007601 + NCIT:C12738 + SCTID:244403000 + Wikipedia:Jugular_vein jugular vein + + + + The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava. + Wikipedia:Jugular_vein + @@ -123762,8 +191325,23 @@ + The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. + AEO:0000194 + BTO:0003834 + EHDAA2:0000001 + EHDAA2:0003235 + EMAPA:36040 + NCIT:C34131 + Wikipedia:Conceptus conceptus + + + + The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. + BTO:0003834 + Wikipedia:Conceptus + @@ -123789,8 +191367,20 @@ + A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres). + NLX:147842 + TAO:0001328 + Wikipedia:Neuromere + ZFA:0001328 neuromere + + + + A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres). + DOI:10.1016/j.tins.2013.06.004 + https://github.com/obophenotype/uberon/issues/318 + @@ -123815,8 +191405,16 @@ + Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. segmental subdivision of nervous system + + + + Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. + FBbt:00005140 + http://orcid.org/0000-0002-6601-2165 + @@ -123842,8 +191440,16 @@ + An organ subunit that is part of a hindbrain [Automatically generated definition]. + FMA:61998 segmental subdivision of hindbrain + + + + An organ subunit that is part of a hindbrain [Automatically generated definition]. + OBOL:automatic + @@ -123874,8 +191480,26 @@ + Organism at the gastrula stage. + BILA:0000060 + BTO:0001403 + FMA:293108 + GAID:1302 + MESH:D005775 + MIAA:0000179 + NCIT:C34057 + NCIT:C34058 + Wikipedia:Gastrula + Wikipedia:Trilaminar_blastocyst gastrula + + + + Organism at the gastrula stage. + Wikipedia:Gastrula + Wikipedia:Trilaminar_blastocyst + @@ -123895,8 +191519,25 @@ + A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]. + MA:0003047 + SCTID:309311006 + VSAO:0000015 + XAO:0004038 + ZFA:0005619 + Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from skeletal tissue + + + + A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000015 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/134 + @@ -123932,8 +191573,59 @@ + Dermis-derived entity that is made of skeletal tissue. dermal skeletal element + + + + Dermis-derived entity that is made of skeletal tissue. + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/206 + + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of an anal canal [Automatically generated definition]. + EMAPA:27221 + EMAPA:27233 + EMAPA:27543 + FMA:15720 + FMA:15724 + NCIT:C32068 + SCTID:245448005 + Wikipedia:Anal_gland + gland of anal canal + + + + + A gland that is part of an anal canal [Automatically generated definition]. + OBOL:automatic + Wikipedia:Anal_gland + @@ -123959,8 +191651,22 @@ + The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]. + AAO:0000094 + EHDAA:6031 + FMA:76621 + NCIT:C34121 + SCTID:155540009 + Wikipedia:Chondrocranium + XAO:0003059 cartilaginous neurocranium + + + + The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]. + Wikipedia:Chondrocranium + @@ -123997,8 +191703,18 @@ + Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. + MA:0002837 + Wikipedia:Intramembranous_ossification intramembranous bone tissue + + + + Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. + GO:0001957 + Wikipedia:Intramembranous_ossification + @@ -124012,8 +191728,21 @@ + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. + AAO:0011129 + TAO:0001890 + VSAO:0000128 + XAO:0004012 + ZFA:0005494 + galen:SkeletalStructure skeletal element + + + + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. + https://orcid.org/0000-0002-6601-2165 + @@ -124038,9 +191767,16 @@ - + A bone that is part of a cranium. + SCTID:181792001 cranial bone + + + + A bone that is part of a cranium. + UBERON:automatic + @@ -124065,8 +191801,15 @@ + Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular. bone of lower jaw + + + + Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular. + https://orcid.org/0000-0002-6601-2165 + @@ -124115,8 +191858,20 @@ + Anatomical system that consists of all the joints of the body. + EMAPA:35150 + FMA:23878 + MA:0003007 + SCTID:361827000 + VSAO:0000181 articular system + + + + Anatomical system that consists of all the joints of the body. + VSAO:0000181 + @@ -124141,8 +191896,16 @@ + A submucosa that is part of a respiratory system [Automatically generated definition]. + MA:0001822 respiratory system submucosa + + + + A submucosa that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124173,8 +191936,16 @@ + A lamina propria that is part of a respiratory system [Automatically generated definition]. + MA:0001821 respiratory system lamina propria + + + + A lamina propria that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124199,8 +191970,55 @@ + A lamina propria that is part of a gastrointestinal system. + MA:0001899 + NCIT:C49299 gastrointestinal system lamina propria + + + + A lamina propria that is part of a gastrointestinal system. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A lamina propria that is part of a gallbladder [Automatically generated definition]. + EMAPA:35371 + FMA:278594 + MA:0001633 + NCIT:C49228 + gallbladder lamina propria + + + + + A lamina propria that is part of a gallbladder [Automatically generated definition]. + OBOL:automatic + @@ -124225,8 +192043,54 @@ + A serous membrane that is part of a digestive system [Automatically generated definition]. + MA:0001522 gastrointestinal system serosa + + + + A serous membrane that is part of a digestive system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a gallbladder [Automatically generated definition]. + EMAPA:35372 + FMA:14659 + MA:0001634 + SCTID:362197006 + gallbladder serosa + + + + + A serous membrane that is part of a gallbladder [Automatically generated definition]. + OBOL:automatic + @@ -124251,8 +192115,18 @@ + An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]. + FMA:13884 + MA:0002791 + NCIT:C119295 heart ventricle wall + + + + An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]. + OBOL:automatic + @@ -124277,8 +192151,22 @@ + The mucous membrane lining the respiratory tract. + BTO:0000973 + FMA:302092 + GAID:304 + MA:0001827 + MESH:D020545 respiratory system mucosa + + + + The mucous membrane lining the respiratory tract. + MESH:A04.760 + MGI:cwg + MP:0002277 + @@ -124333,8 +192221,122 @@ + A mucosa that is part of a gastrointestinal system. + BTO:0000546 + BTO:0005568 + EMAPA:36591 + MA:0001521 + SCTID:410433007 + The gut mucosa of amphioxus has insulin-secreting cells. http://www.ncbi.nlm.nih.gov/pubmed/16417468 gastrointestinal system mucosa + + + + A mucosa that is part of a gastrointestinal system. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + A mucous gland that is part of the skin. + EMAPA:35775 + MA:0000148 + skin mucous gland + + + + + A mucous gland that is part of the skin. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + A secretion that is part of a endocrine pancreas [Automatically generated definition]. + MA:0002517 + NCIT:C33255 + secretion of endocrine pancreas + + + + + A secretion that is part of a endocrine pancreas [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A secretion that is part of a exocrine pancreas [Automatically generated definition]. + MA:0002518 + NCIT:C33256 + secretion of exocrine pancreas + + + + + A secretion that is part of a exocrine pancreas [Automatically generated definition]. + OBOL:automatic + @@ -124359,8 +192361,53 @@ + A secretion that is part of a esophagus [Automatically generated definition]. + FMA:79662 + MA:0002514 + NCIT:C52555 esophagus secretion + + + + A secretion that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A secretion that is part of a pancreas [Automatically generated definition]. + MA:0002516 + NCIT:C13270 + pancreas secretion + + + + + A secretion that is part of a pancreas [Automatically generated definition]. + OBOL:automatic + @@ -124386,8 +192433,17 @@ + Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia. + EMAPA:36296 + MA:0002854 blood vessel layer + + + + Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia. + http://orcid.org/0000-0002-6601-2165 + @@ -124420,8 +192476,22 @@ + The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi. + BTO:0000419 + CALOHA:TS-0023 + EMAPA:32827 + MA:0001480 + SCTID:321764001 respiratory tract epithelium + + + + The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi. + ISBN:0-683-40008-8 + MGI:anna + MP:0010942 + @@ -124446,8 +192516,18 @@ + An epithelium that is part of a respiratory system [Automatically generated definition]. + CALOHA:TS-0023 + EMAPA:32826 + MA:0001823 respiratory system epithelium + + + + An epithelium that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124472,8 +192552,17 @@ + An epithelium that is part of a digestive system [Automatically generated definition]. + EMAPA:32683 + MA:0001520 gastrointestinal system epithelium + + + + An epithelium that is part of a digestive system [Automatically generated definition]. + OBOL:automatic + @@ -124498,8 +192587,60 @@ + An epithelium that is part of a lower respiratory tract [Automatically generated definition]. + MA:0001481 lower respiratory tract epithelium + + + + An epithelium that is part of a lower respiratory tract [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any epithelium that lines one of the bile ducts. + BTO:0000417 + MA:0001629 + NCIT:C43616 + bile duct epithelium + + + + + Any epithelium that lines one of the bile ducts. + http://orcid.org/0000-0002-6601-2165 + @@ -124543,8 +192684,95 @@ + The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO]. + BTO:0003511 + EMAPA:35121 + FMA:63915 + MA:0001771 + NCIT:C12867 pulmonary alveolus epithelium + + + + The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO]. + BTO:0003511 + MP:0010898 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]. + EHDAA2:0000742 + EHDAA:3051 + MA:0002661 + NCIT:C43618 + extrahepatic bile duct epithelium + + + + + An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]. + EHDAA2:0000743 + EHDAA:3053 + MA:0002662 + NCIT:C43617 + intrahepatic bile duct epithelium + + + + + An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]. + OBOL:automatic + @@ -124569,8 +192797,16 @@ + A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]. + MA:0001829 respiratory system skeletal muscle + + + + A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124595,8 +192831,52 @@ + A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]. + EMAPA:36523 + MA:0001572 + Most muscle tissue lining the digestive tract is smooth, but part of the externa of the esophagus is skeletal esophagus skeletal muscle + + + + A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]. + MA:0001530 + anal region skeletal muscle + + + + + A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]. + OBOL:automatic + @@ -124621,8 +192901,51 @@ + A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]. + MA:0001578 lip skeletal muscle + + + + A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + Smooth muscle tissue in all or part of a hepatic duct. + MA:0001640 + hepatic duct smooth muscle + + + + + Smooth muscle tissue in all or part of a hepatic duct. + http://orcid.org/0000-0002-6601-2165 + @@ -124648,9 +192971,16 @@ - + An endothelium of artery that is part of a respiratory system [Automatically generated definition]. + MA:0001801 respiratory system arterial endothelium + + + + An endothelium of artery that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124676,9 +193006,16 @@ - + An endothelium of vein that is part of a respiratory system [Automatically generated definition]. + MA:0001811 respiratory system venous endothelium + + + + An endothelium of vein that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124704,8 +193041,22 @@ + The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall. + BTO:0000394 + CALOHA:TS-0047 + EFO:0002597 + EMAPA:35134 + MA:0000701 + NCIT:C49190 aorta endothelium + + + + The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall. + MGI:csmith + MP:0009864 + @@ -124730,8 +193081,54 @@ + An endothelium that is part of the cardiovascular system. + BTO:0001853 + EMAPA:35201 + GAID:519 + MA:0000717 + MESH:D004730 + NCIT:C13053 + TAO:0002171 + VHOG:0001217 + XAO:0000356 + ZFA:0001639 cardiovascular system endothelium + + + + An endothelium that is part of the cardiovascular system. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a digestive system [Automatically generated definition]. + MA:0001900 + gastrointestinal system mesentery + + + + + A mesentery that is part of a digestive system [Automatically generated definition]. + OBOL:automatic + @@ -124756,8 +193153,16 @@ + A connective tissue that surrounds a skeletal muscle tissue. + MA:0002868 skeletal muscle connective tissue + + + + A connective tissue that surrounds a skeletal muscle tissue. + OBOL:automatic + @@ -124782,8 +193187,18 @@ + A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid. + EMAPA:35334 + MA:0000267 + Examples: harderian gland, accessory lacrimal gland, gland of Moll, gland of Zeis, nictitating membrane glands eye gland + + + + A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid. + http://orcid.org/0000-0002-6601-2165 + @@ -124808,8 +193223,18 @@ + An alveolus that is part of a right lung [Automatically generated definition]. + EMAPA:35997 + MA:0001786 + NCIT:C49278 right lung alveolus + + + + An alveolus that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -124834,8 +193259,18 @@ + An alveolus that is part of a left lung [Automatically generated definition]. + EMAPA:19182 + MA:0001777 + NCIT:C49251 left lung alveolus + + + + An alveolus that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -124861,9 +193296,55 @@ - + A vasculature that is part of a retina [Automatically generated definition]. + FMA:76552 + MESH:D012171 vasculature of retina + + + + A vasculature that is part of a retina [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye. + AAO:0000343 + FMA:84961 + SCTID:280541000 + Wikipedia:Orbit_(anatomy) + ZFA:0005558 + orbital cavity + + + + + Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye. + http://orcid.org/0000-0002-6601-2165 + @@ -124877,8 +193358,20 @@ + Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. + AAO:0011102 + BILA:0000044 + FMA:295568 + Wikipedia:Lateral_plate_mesoderm#Division_into_layers + XAO:0000276 splanchnic layer of lateral plate mesoderm + + + + Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. + Wikipedia:Lateral_plate_mesoderm#Division_into_layers + @@ -124898,8 +193391,22 @@ + A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]. + EHDAA2:0001903 + EHDAA:383 + EMAPA:16181 + FMA:295564 + NCIT:C34303 + VHOG:0000558 + Wikipedia:Splanchnopleure splanchnopleure + + + + A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]. + Wikipedia:Splanchnopleure + @@ -124919,8 +193426,22 @@ + A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]. + EHDAA2:0001847 + EHDAA:381 + EMAPA:16180 + FMA:295566 + NCIT:C34301 + VHOG:0000557 + Wikipedia:Somatopleure somatopleure + + + + A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]. + Wikipedia:Somatopleure + @@ -124940,8 +193461,19 @@ + The central region of trunk mesoderm. This tissue forms the notochord. + AAO:0000478 + EFO:0003426 + TAO:0000091 + ZFA:0000091 chordamesoderm + + + + The central region of trunk mesoderm. This tissue forms the notochord. + https://orcid.org/0000-0002-6601-2165 + @@ -124973,9 +193505,16 @@ - + The mass of tissue made up of mesenchymal cells in the lung. + EMAPA:32866 lung mesenchyme + + + + The mass of tissue made up of mesenchymal cells in the lung. + GO:0060484 + @@ -125007,8 +193546,21 @@ + A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung. + BTO:0003149 + EMAPA:35433 + MA:0000421 + NCIT:C49473 + Wikipedia:Alveolar_septum interalveolar septum + + + + A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung. + LG:0012625 + Wikipedia:Alveolar_septum + @@ -125040,8 +193592,22 @@ + A wall that contains the alveoli. + BTO:0002543 + EMAPA:35120 + FMA:14117 + MA:0002568 + NCIT:C13085 + SCTID:361965008 alveolar wall + + + + A wall that contains the alveoli. + LG:0012626 + MP:0010903 + @@ -125066,8 +193632,17 @@ + Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus. + EMAPA:35122 + MA:0002759 alveolar smooth muscle + + + + Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus. + LG:0012628 + @@ -125108,9 +193683,19 @@ - + A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila. + BTO:0000966 + EV:0100351 + TADS:0000232 + for the vertebrate-specific structure, see UBERON:0000941 (cranial nerve II) neuron projection bundle connecting eye with brain + + + + A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila. + http://orcid.org/0000-0002-6601-2165 + @@ -125124,8 +193709,15 @@ + Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts. articulation + + + + Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts. + http://orcid.org/0000-0002-6601-2165 + @@ -125149,8 +193741,48 @@ + A portion of the gut that is derived from ectoderm. ectodermal part of digestive tract + + + + A portion of the gut that is derived from ectoderm. + GO:0007439 + + + + + + + + + + + + + + + + + + + + + The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]. + FMA:49179 + NCIT:C33010 + SCTID:279973004 + Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract + galen:LowerGastrointestinalTract + lower digestive tract + + + + + The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]. + Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract + @@ -125164,8 +193796,20 @@ + The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum. + FMA:49177 + NCIT:C33837 + SCTID:181244000 + Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract + galen:UpperGastrointestinalTract upper digestive tract + + + + The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum. + Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract + @@ -125191,8 +193835,18 @@ + An epithelium surrounding a gonad. + EHDAA:4032 + EHDAA:5931 + NCIT:C32676 epithelium of gonad + + + + An epithelium surrounding a gonad. + OBOL:automatic + @@ -125217,8 +193871,205 @@ + An epithelium surrounding an ovary. + BTO:0003661 epithelium of female gonad + + + + An epithelium surrounding an ovary. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0000171 + EMAPA:16561 + EMAPA_RETIRED:16565 + VHOG:0001351 + biliary bud + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct. + CALOHA:TS-2348 + FMA:15076 + GAID:283 + MESH:D014670 + NCIT:C13011 + SCTID:362200007 + TAO:0005167 + Wikipedia:Ampulla_of_Vater + ZFA:0005167 + galen:AmpullaOfVater + hepatopancreatic ampulla + + + + + A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct. + Wikipedia:Ampulla_of_Vater + + + + + + + + + + + + + + + One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct. + EMAPA:18662 + FMA:15953 + MA:0003107 + NCIT:C119578 + SCTID:245389007 + duodenal papilla + + + + + One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct. + http://medical-dictionary.thefreedictionary.com/duodenal+papilla + + + + + + + + + + + + + + + + + + + + + + + + + + + Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]. + EMAPA:18663 + FMA:15077 + GAID:285 + MESH:D009803 + NCIT:C13065 + SCTID:181271000 + Wikipedia:Sphincter_of_ampulla + sphincter of hepatopancreatic ampulla + + + + + Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]. + Wikipedia:Sphincter_of_ampulla + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A sphincter muscle that is part of a anal region. + EMAPA:36052 + anal sphincter + + + + + A sphincter muscle that is part of a anal region. + OBOL:automatic + @@ -125249,9 +194100,16 @@ - + A proximal-distal subdivision of the digestive tract. + FMA:71131 subdivision of digestive tract + + + + A proximal-distal subdivision of the digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -125271,8 +194129,16 @@ + A part of a wall of an organ that forms a layer. + FMA:82485 organ component layer + + + + A part of a wall of an organ that forms a layer. + http://orcid.org/0000-0002-6601-2165 + @@ -125298,8 +194164,360 @@ + The tissue underlying the tunica mucosa of the pharynx. + BTO:0002113 + FMA:75144 + SCTID:19594009 submucosa of pharynx + + + + The tissue underlying the tunica mucosa of the pharynx. + BTO:0002113 + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a cystic duct [Automatically generated definition]. + FMA:18013 + submucosa of cystic duct + + + + + A submucosa that is part of a cystic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a sigmoid colon [Automatically generated definition]. + FMA:15027 + submucosa of sigmoid colon + + + + + A submucosa that is part of a sigmoid colon [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a body of stomach [Automatically generated definition]. + FMA:17059 + submucosa of body of stomach + + + + + A submucosa that is part of a body of stomach [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a pyloric antrum [Automatically generated definition]. + FMA:17060 + submucosa of pyloric antrum + + + + + A submucosa that is part of a pyloric antrum [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a pylorus [Automatically generated definition]. + EMAPA:27201 + FMA:17462 + submucosa of pylorus + + + + + A submucosa that is part of a pylorus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a biliary tree [Automatically generated definition]. + FMA:18009 + submucosa of biliary tree + + + + + A submucosa that is part of a biliary tree [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a common bile duct [Automatically generated definition]. + FMA:18011 + submucosa of common bile duct + + + + + A submucosa that is part of a common bile duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a common hepatic duct [Automatically generated definition]. + FMA:18014 + submucosa of common hepatic duct + + + + + A submucosa that is part of a common hepatic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a right hepatic duct [Automatically generated definition]. + FMA:18015 + submucosa of right hepatic duct + + + + + A submucosa that is part of a right hepatic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a left hepatic duct [Automatically generated definition]. + FMA:18017 + submucosa of left hepatic duct + + + + + A submucosa that is part of a left hepatic duct [Automatically generated definition]. + OBOL:automatic + @@ -125325,8 +194543,402 @@ + A submucosa that is part of a bronchiole [Automatically generated definition]. + FMA:62775 submucosa of bronchiole + + + + A submucosa that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a cystic duct [Automatically generated definition]. + FMA:14690 + mucosa of cystic duct + + + + + A mucosa that is part of a cystic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a sigmoid colon [Automatically generated definition]. + FMA:15026 + mucosa of sigmoid colon + + + + + A mucosa that is part of a sigmoid colon [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a body of stomach [Automatically generated definition]. + FMA:17054 + mucosa of body of stomach + + + + + A mucosa that is part of a body of stomach [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a pyloric antrum [Automatically generated definition]. + BTO:0004107 + FMA:17055 + mucosa of pyloric antrum + + + + + A mucosa that is part of a pyloric antrum [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a pylorus [Automatically generated definition]. + BTO:0004110 + EMAPA:27199 + FMA:17461 + mucosa of pylorus + + + + + A mucosa that is part of a pylorus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a biliary tree [Automatically generated definition]. + FMA:14695 + mucosa of biliary tree + + + + + A mucosa that is part of a biliary tree [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a common bile duct [Automatically generated definition]. + FMA:14688 + mucosa of common bile duct + + + + + A mucosa that is part of a common bile duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a common hepatic duct [Automatically generated definition]. + FMA:14691 + mucosa of common hepatic duct + + + + + A mucosa that is part of a common hepatic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a right hepatic duct [Automatically generated definition]. + FMA:14692 + mucosa of right hepatic duct + + + + + A mucosa that is part of a right hepatic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a left hepatic duct [Automatically generated definition]. + FMA:14693 + mucosa of left hepatic duct + + + + + A mucosa that is part of a left hepatic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a upper lip [Automatically generated definition]. + FMA:59832 + NCIT:C12224 + SCTID:362088009 + mucosa of upper lip + + + + + A mucosa that is part of a upper lip [Automatically generated definition]. + OBOL:automatic + @@ -125351,8 +194963,54 @@ + A mucosa that is part of a lower lip [Automatically generated definition]. + FMA:59833 + NCIT:C12225 + SCTID:362089001 mucosa of lower lip + + + + A mucosa that is part of a lower lip [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a gallbladder [Automatically generated definition]. + FMA:14662 + SCTID:362196002 + mucosa of gallbladder + + + + + A mucosa that is part of a gallbladder [Automatically generated definition]. + OBOL:automatic + @@ -125378,8 +195036,17 @@ + A mucosa that is part of a bronchiole [Automatically generated definition]. + FMA:62774 + SCTID:10887006 mucosa of bronchiole + + + + A mucosa that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -125404,8 +195071,16 @@ + A mucosa that is part of a terminal bronchiole [Automatically generated definition]. + FMA:263232 mucosa of terminal bronchiole + + + + A mucosa that is part of a terminal bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -125430,8 +195105,16 @@ + A mucosa that is part of a respiratory bronchiole [Automatically generated definition]. + FMA:263238 mucosa of respiratory bronchiole + + + + A mucosa that is part of a respiratory bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -125452,10 +195135,21 @@ - - + An external genitalia that is part of a female reproductive system [Automatically generated definition]. + BTO:0003100 + EMAPA:30984 + FMA:45649 + SCTID:362234008 + galen:FemaleExternalGenitalia + TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 external female genitalia + + + + An external genitalia that is part of a female reproductive system [Automatically generated definition]. + OBOL:automatic + @@ -125480,8 +195174,15 @@ + An organ that is part of a immune system [Automatically generated definition]. immune organ + + + + An organ that is part of a immune system [Automatically generated definition]. + OBOL:automatic + @@ -125506,8 +195207,17 @@ + A gland that is part of a hemolymphoid system [Automatically generated definition]. + EMAPA:18766 + MA:0002962 hemolymphoid system gland + + + + A gland that is part of a hemolymphoid system [Automatically generated definition]. + OBOL:automatic + @@ -125521,8 +195231,25 @@ + The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. + AAO:0011071 + EMAPA:35594 + FMA:295624 + NCIT:C34224 + SCTID:361463007 + Wikipedia:Neural_groove + XAO:0000248 + neuronames:1363 neural groove + + + + The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. + GO:0001842 + Wikipedia:Neural_groove + http://orcid.org/0000-0002-6601-2165 + @@ -125546,8 +195273,90 @@ + One of the two elevated edges of the neural groove[GO,MP]. + EHDAA2:0001249 + FMA:295618 + NCIT:C34223 + SCTID:361461009 + Wikipedia:Neural_fold + XAO:0004087 + neuronames:1364 neural fold + + + + One of the two elevated edges of the neural groove[GO,MP]. + GO:0001842 + MP:0011256 + Wikipedia:Neural_fold + + + + + + + + + + + + + + + + + + + + + + + + + + Missing definition for term UBERON:0005064. Please replace it using linked reference. + left ventricular trabecular myocardium + + + + + Missing definition for term UBERON:0005064. Please replace it using linked reference. + GO:0003225 + + + + + + + + + + + + + + + + + + + + + + + + + + Missing definition for term UBERON:0005066. Please replace it using linked reference. + right ventricular trabecular myocardium + + + + + Missing definition for term UBERON:0005066. Please replace it using linked reference. + GO:0003227 + @@ -125561,8 +195370,19 @@ + A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]. + EFO:0003498 + TAO:0000133 + ZFA:0000133 neural rod + + + + A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]. + GO:0014024 + ZFA:0000133 + @@ -125604,8 +195424,15 @@ + An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord. hindbrain-spinal cord boundary + + + + An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord. + OBOL:automatic + @@ -125630,8 +195457,18 @@ + A hole in a tube[GO]. + AEO:0000078 + EHDAA2:0004618 + RETIRED_EHDAA2:0003078 tube lumen + + + + A hole in a tube[GO]. + GO:0060609 + @@ -125646,8 +195483,16 @@ + An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]. + AEO:0000218 ectodermal placode + + + + An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]. + GO:0060788 + @@ -125667,8 +195512,16 @@ + Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. + FMA:30316 muscle structure + + + + Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. + GO:0061061 + @@ -125682,6 +195535,11 @@ + EHDAA2:0001841 + EHDAA:484 + EMAPA:16239 + FMA:70318 + VHOG:0000489 right horn of sinus venosus @@ -125691,8 +195549,16 @@ + A bud is a protrusion that forms from an epithelial sheet by localized folding. + BTO:0001639 epithelial bud + + + + A bud is a protrusion that forms from an epithelial sheet by localized folding. + GO:0060572 + @@ -125717,8 +195583,15 @@ + Any anatomical structure that is part of the reproductive system. reproductive structure + + + + Any anatomical structure that is part of the reproductive system. + http://orcid.org/0000-0002-6601-2165 + @@ -125726,8 +195599,15 @@ + An epithelial sheet bent on a linear axis. epithelial fold + + + + An epithelial sheet bent on a linear axis. + GO:0060571 + @@ -125753,8 +195633,16 @@ + The functional tissue of the central nervous system consisting of neurons and glial cells. parenchyma of central nervous system + + + + The functional tissue of the central nervous system consisting of neurons and glial cells. + CL:tm + https://github.com/obophenotype/uberon/issues/8 + @@ -125768,8 +195656,18 @@ + A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. + AAO:0011000 + CARO:0001000 + FMA:83115 multi cell part structure + + + + A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. + CARO:0001000 + @@ -125777,9 +195675,54 @@ - + Connective tissue between the cellular elements of a structure. + FMA:86301 + SCTID:85293002 interstitial tissue + + + + Connective tissue between the cellular elements of a structure. + http://medical-dictionary.thefreedictionary.com/tissue + + + + + + + + + + + + + + + + + + + + + Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion). + EHDAA2:0000741 + EHDAA:3049 + EMAPA:16843 + FMA:71891 + MA:0000357 + NCIT:C32730 + SCTID:245399002 + VHOG:0000219 + galen:HepaticDuct + hepatic duct + + + + + Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion). + http://orcid.org/0000-0002-6601-2165 + @@ -125804,8 +195747,17 @@ + An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland. + MA:0000522 + SCTID:272631008 abdomen element + + + + An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland. + http://orcid.org/0000-0002-6601-2165 + @@ -125830,8 +195782,16 @@ + An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region. + MA:0000529 abdominal segment element + + + + An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region. + http://orcid.org/0000-0002-6601-2165 + @@ -125856,8 +195816,16 @@ + An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back. + MA:0001901 dorsal region element + + + + An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back. + http://orcid.org/0000-0002-6601-2165 + @@ -125882,8 +195850,16 @@ + An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. + MA:0000516 trunk region element + + + + An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. + http://orcid.org/0000-0002-6601-2165 + @@ -125909,8 +195885,16 @@ + An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. + MA:0000557 thoracic cavity element + + + + An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. + http://orcid.org/0000-0002-6601-2165 + @@ -125935,8 +195919,16 @@ + An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. + MA:0000563 thoracic segment organ + + + + An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. + http://orcid.org/0000-0002-6601-2165 + @@ -125956,8 +195948,175 @@ + A vein that is part of a thorax [Automatically generated definition]. + MA:0002235 + NCIT:C53142 + SCTID:281472008 thoracic vein + + + + A vein that is part of a thorax [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen. + EMAPA:36574 + FMA:7473 + MA:0002937 + SCTID:197423006 + trachea gland + + + + + A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen. + ISBN:1451113412 + MGI:Anna + PMID:15973734 + http://medical-dictionary.thefreedictionary.com/tracheal+glands + https://github.com/obophenotype/uberon/issues/1197 + + + + + + + + + + + + + + + + + + + + + + + + + + A parenchyma that is part of a right lobe of liver [Automatically generated definition]. + EHDAA2:0001010 + EMAPA:18317 + FMA:71657 + VHOG:0000840 + liver right lobe parenchyma + + + + + A parenchyma that is part of a right lobe of liver [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A parenchyma that is part of a left lobe of liver [Automatically generated definition]. + EHDAA2:0001002 + EMAPA:18310 + FMA:71658 + VHOG:0000839 + liver left lobe parenchyma + + + + + A parenchyma that is part of a left lobe of liver [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An ectoderm that is part of a medial nasal prominence [Automatically generated definition]. + EHDAA2:0001078 + EMAPA:16809 + FMA:312675 + VHOG:0000803 + medial-nasal process ectoderm + + + + + An ectoderm that is part of a medial nasal prominence [Automatically generated definition]. + OBOL:automatic + @@ -125982,8 +196141,19 @@ + An ectoderm that is part of a optic eminence [Automatically generated definition]. + EHDAA:940 + EMAPA:16539 + RETIRED_EHDAA2:0001309 + VHOG:0001105 optic eminence ectoderm + + + + An ectoderm that is part of a optic eminence [Automatically generated definition]. + OBOL:automatic + @@ -125991,6 +196161,9 @@ + EHDAA2:0001154 + EMAPA:17078 + VHOG:0000320 basal plate metencephalon @@ -126017,8 +196190,19 @@ + An endocardium that is part of a interventricular septum [Automatically generated definition]. + EHDAA2:0000886 + EHDAA2:0000887 + FMA:83584 + VHOG:0000615 interventricular septum endocardium + + + + An endocardium that is part of a interventricular septum [Automatically generated definition]. + OBOL:automatic + @@ -126043,8 +196227,17 @@ + A myocardium that is part of a bulbus cordis [Automatically generated definition]. + EMAPA:36488 + VHOG:0000609 bulbus cordis myocardium + + + + A myocardium that is part of a bulbus cordis [Automatically generated definition]. + OBOL:automatic + @@ -126069,8 +196262,16 @@ + A gland that is part of a stomodeum. + VHOG:0000658 stomatodeum gland + + + + A gland that is part of a stomodeum. + OBOL:automatic + @@ -126097,8 +196298,18 @@ + An anatomical cavity that is part of a yolk sac [Automatically generated definition]. + EMAPA:16055 + FMA:63942 + VHOG:0000843 yolk sac cavity + + + + An anatomical cavity that is part of a yolk sac [Automatically generated definition]. + OBOL:automatic + @@ -126130,8 +196341,25 @@ + Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. + EFO:0003492 + EHDAA2:0000732 + EHDAA:179 + EMAPA:16098 + EMAPA_RETIRED:16269 + FMA:76622 + TAO:0000113 + VHOG:0000332 + ZFA:0000113 head mesenchyme + + + + Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. + ISBN:0683400088 + MP:0011260 + @@ -126167,8 +196395,22 @@ + Mesenchyme that is part of a developing trunk. + EFO:0003485 + EHDAA2:0002092 + EHDAA:377 + EMAPA:16177 + TAO:0000081 + VHOG:0000281 + ZFA:0000081 trunk mesenchyme + + + + Mesenchyme that is part of a developing trunk. + OBOL:automatic + @@ -126182,8 +196424,27 @@ + The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. + BTO:0000758 + CALOHA:TS-0607 + CALOHA:TS-2365 + DHBA:10662 + EHDAA2:0001207 + EHDAA:5526 + EMAPA:17082 + HBA:9512 + MA:0000205 + VHOG:0000456 + Wikipedia:Myelencephalon myelencephalon + + + + The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. + BTO:0000758 + Wikipedia:Myelencephalon + @@ -126208,8 +196469,16 @@ + A portion of tissue that is part of an embryo. + CALOHA:TS-2100 embryonic tissue + + + + A portion of tissue that is part of an embryo. + OBOL:automatic + @@ -126234,8 +196503,20 @@ + Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo. + BTO:0003360 + CALOHA:TS-2119 + EFO:0001406 + MAT:0000061 + MIAA:0000061 extraembryonic tissue + + + + Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo. + https://orcid.org/0000-0002-6601-2165 + @@ -126260,8 +196541,16 @@ + The endothelial lining of the endocardium. + FMA:83596 endocardial endothelium + + + + The endothelial lining of the endocardium. + UBERON:cjm + @@ -126286,8 +196575,16 @@ + An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]. + BTO:0000137 pulmonary artery endothelium + + + + An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]. + GO:0061155 + @@ -126312,8 +196609,16 @@ + A lamina propria that is part of a mucosa of oral region. + EMAPA:26947 oral lamina propria + + + + A lamina propria that is part of a mucosa of oral region. + OBOL:automatic + @@ -126338,8 +196643,18 @@ + A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]. + FMA:13225 + Wikipedia:Ventricular_outflow_tract + XAO:0004140 outflow tract of ventricle + + + + A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]. + Wikipedia:Ventricular_outflow_tract + @@ -126364,8 +196679,19 @@ + An outflow tract that is part of a aorta. + EHDAA2:0001353 + EMAPA:17329 + MA:0000101 + VHOG:0001394 outflow tract aortic component + + + + An outflow tract that is part of a aorta. + OBOL:automatic + @@ -126373,6 +196699,11 @@ + EHDAA2:0001359 + EHDAA:4401 + EMAPA:17330 + MA:0000102 + VHOG:0001395 outflow tract pulmonary component @@ -126415,8 +196746,15 @@ + An array of photoreceptors and any supporting cells found in an eye. photoreceptor array + + + + An array of photoreceptors and any supporting cells found in an eye. + https://orcid.org/0000-0002-6601-2165 + @@ -126436,8 +196774,15 @@ + A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array. transparent eye structure + + + + A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array. + http://orcid.org/0000-0002-6601-2165 + @@ -126445,8 +196790,36 @@ + One of: the common carotid artery, or its branches, the external and internal carotid arteries. + AAO:0010217 + BTO:0000168 + CALOHA:TS-0116 + EFO:0000818 + EHDAA:6385 + EMAPA:18609 + EV:0100379 + FMA:70504 + GAID:478 + MA:0001925 + MAT:0000501 + MESH:D002339 + NCIT:C12687 + SCTID:362040006 + SCTID:69105007 + TAO:0000097 + VHOG:0000266 + Wikipedia:Carotid_artery + ZFA:0000097 + galen:CarotidArtery carotid artery segment + + + + One of: the common carotid artery, or its branches, the external and internal carotid arteries. + Wikipedia:Carotid_artery + https://sourceforge.net/tracker/?func=detail&aid=3486870&group_id=76834&atid=994764 + @@ -126471,8 +196844,17 @@ + A sex gland that is part of a female reproductive system. + BTO:0000254 + MA:0000383 female reproductive gland + + + + A sex gland that is part of a female reproductive system. + OBOL:automatic + @@ -126492,8 +196874,28 @@ + The part of the digestive system that excludes the hepatobiliary system. + BTO:0000058 + CALOHA:TS-0407 + EHDAA2:0000110 + EHDAA:514 + EMAPA:16246 + FMA:71132 + GAID:294 + MA:0000323 + MESH:D041981 + NCIT:C12378 + SCTID:373871007 + VHOG:0000412 + galen:GastrointestinalTract alimentary part of gastrointestinal system + + + + The part of the digestive system that excludes the hepatobiliary system. + http://orcid.org/0000-0002-6601-2165 + @@ -126530,8 +196932,21 @@ + A limb bud that develops into a forelimb or pectoral fin. + EFO:0003430 + TAO:0000141 + VHOG:0001754 + VHOG_RETIRED:0001259 + ZFA:0000141 + at this time we have no need to name a more specific 'pectoral fin bud' class, but we may in future pectoral appendage bud + + + + A limb bud that develops into a forelimb or pectoral fin. + OBOL:automatic + @@ -126562,8 +196977,22 @@ + An apical ectodermal ridge that is part of a pectoral appendage bud. + EFO:0003487 + EHDAA2:0000138 + EMAPA:16778 + TAO:0000085 + TAO:0000736 + VHOG:0001064 + ZFA:0000085 pectoral appendage apical ectodermal ridge + + + + An apical ectodermal ridge that is part of a pectoral appendage bud. + OBOL:automatic + @@ -126577,9 +197006,11 @@ - - - + AEO:0000125 + CALOHA:TS-2122 + EHDAA2:0003125 + FMA:292313 + MIAA:0000019 developing anatomical structure @@ -126613,8 +197044,20 @@ + Portion of tissue that is the inner layer of the optic cup and will become the neural retina. + EHDAA2:0001304 + EMAPA:16675 + TAO:0001071 + VHOG:0000490 + ZFA:0001071 presumptive neural retina + + + + Portion of tissue that is the inner layer of the optic cup and will become the neural retina. + ZFIN:curator + @@ -126629,8 +197072,23 @@ + Portion of tissue that gives rise to the lens. + EHDAA2:0000983 + EHDAA:4737 + EMAPA:17163 + SCTID:361510002 + TAO:0002205 + VHOG:0001163 + ZFA:0001679 lens vesicle + + + + Portion of tissue that gives rise to the lens. + ZFIN:curator + https://sourceforge.net/tracker/?func=detail&atid=994726&aid=3514998&group_id=76834 + @@ -126647,8 +197105,17 @@ + Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea. + TAO:0002188 + ZFA:0001688 corneal primordium + + + + Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea. + ZFIN:ZDB-PUB-061010-3 + @@ -126663,8 +197130,21 @@ + Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]. + EHDAA2:0002156 + EHDAA:669 + TAO:0000818 + VHOG:0001208 + XAO:0004191 + ZFA:0000818 vagal neural crest + + + + Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]. + ZFIN:curator + @@ -126686,8 +197166,21 @@ + The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates. + EHDAA2:0004145 + EHDAA:9826 + EMAPA:36461 + FMA:71008 + RETIRED_EHDAA2:0000133 + SCTID:361527005 aortic sac + + + + The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates. + MP:0012510 + @@ -126707,11 +197200,94 @@ + FMA:24219 + SCTID:123958008 cervical region + + + + + + + + + + + In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:. + EHDAA2:0000308 + EHDAA:8570 + FMA:14771 + MA:0003094 + SCTID:244263001 + Wikipedia:Common_hepatic_artery + galen:CommonHepaticArtery + common hepatic artery + + + + + In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:. + Wikipedia:Common_hepatic_artery + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa. + AAO:0000194 + EHDAA2:0000552 + EHDAA:10629 + EMAPA:18712 + FMA:53154 + SCTID:369439002 + VHOG:0001543 + Wikipedia:Foramen_rotundum + foramen rotundum + + + + + The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa. + Wikipedia:Foramen_rotundum + + + + @@ -126734,8 +197310,20 @@ + A vitelline vein that is in the left side of a multicellular organism. + EHDAA2:0000971 + EMAPA:16380 + EMAPA:16698 + FMA:70307 + SCTID:361446008 left vitelline vein + + + + A vitelline vein that is in the left side of a multicellular organism. + OBOL:automatic + @@ -126761,8 +197349,20 @@ + A vitelline vein that is in the right side of a multicellular organism. + EHDAA2:0001766 + EMAPA:16381 + EMAPA:16699 + FMA:70306 + SCTID:361445007 right vitelline vein + + + + A vitelline vein that is in the right side of a multicellular organism. + OBOL:automatic + @@ -126776,8 +197376,19 @@ + A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]. + BAMS:slim + BAMS:slm + neuronames:629 sulcus limitans of neural tube + + + + A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]. + http://medical-dictionary.thefreedictionary.com/Sulcus+limitans + http://www.ncbi.nlm.nih.gov/books/NBK10047 + @@ -126803,8 +197414,26 @@ + The paired veins that carry blood from the yolk sac back to the embryo. + EMAPA:36021 + FMA:70305 + NCIT:C34329 + RETIRED_EHDAA2:0002209 + SCTID:2730004 + SCTID:308832003 + VHOG:0000401 + Wikipedia:Vitelline_veins + XAO:0000376 + XAO:0004147 vitelline vein + + + + The paired veins that carry blood from the yolk sac back to the embryo. + MGI:csmith + MP:0010666 + @@ -126818,8 +197447,22 @@ + Portion of tissue on the side of the lumen of the neural tube. + EHDAA2:0001257 + EHDAA:2873 + EHDAA:912 + EMAPA:16166 + TAO:0001435 + VHOG:0000513 + ZFA:0001435 neural tube lateral wall + + + + Portion of tissue on the side of the lumen of the neural tube. + ZFA:0001435 + @@ -126828,6 +197471,15 @@ + EFO:0003643 + EHDAA:257 + EMAPA:16074 + RETIRED_EHDAA2:0001273 + TAO:0001178 + VHOG:0001372 + XAO:0004091 + ZFA:0001178 + Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998). non-neural ectoderm @@ -126850,8 +197502,24 @@ + Multi-tissue structure that arises from the heart rudiment and will become the heart tube. + EHDAA2:0001512 + EHDAA:424 + EHDAA:436 + EMAPA:16215 + FMA:321916 + SCTID:361522004 + TAO:0000149 + Wikipedia:Primitive_heart_tube + ZFA:0000149 primitive heart tube + + + + Multi-tissue structure that arises from the heart rudiment and will become the heart tube. + ZFA:0000149 + @@ -126876,8 +197544,17 @@ + A neural tube lateral wall that is part of a rhombomere. + EMAPA:32819 + EMAPA:35364 rhombomere lateral wall + + + + A neural tube lateral wall that is part of a rhombomere. + OBOL:automatic + @@ -126893,8 +197570,22 @@ + Cranial neural crest which gives rise to the trigeminal ganglion. + EFO:0003484 + EHDAA2:0002083 + EHDAA:667 + EMAPA:16170 + TAO:0000080 + VHOG:0000269 + ZFA:0000080 trigeminal neural crest + + + + Cranial neural crest which gives rise to the trigeminal ganglion. + ZFA:0000080 + @@ -126914,8 +197605,22 @@ + Portion of tissue that gives rise to the immature gonad. + EFO:0003651 + EHDAA:5927 + EMAPA:17204 + RETIRED_EHDAA2:0002148 + TAO:0001262 + WBbt:0008366 + ZFA:0001262 gonad primordium + + + + Portion of tissue that gives rise to the immature gonad. + ZFA:0001262 + @@ -126948,8 +197653,18 @@ + Somite located in the head region, caudal to the otic vesicle. + EHDAA2:0003437 + EMAPA:16172 + XAO:0000313 head somite + + + + Somite located in the head region, caudal to the otic vesicle. + PMID:11830559 + @@ -126975,8 +197690,19 @@ + A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum. + AAO:0011059 + EFO:0002578 + EMAPA:36007 + XAO:0001002 lung primordium + + + + A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum. + XAO:0001002 + @@ -127001,8 +197727,78 @@ + A somite that is part of a trunk. + AAO:0010385 + EHDAA2:0003438 + EMAPA:16184 + XAO:0000314 trunk somite + + + + A somite that is part of a trunk. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum. + EHDAA2:0000416 + EHDAA:3001 + EMAPA:17025 + MA:0001618 + NCIT:C34142 + VHOG:0000352 + Wikipedia:Dorsal_mesentery + dorsal mesogastrium + + + + + The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum. + Wikipedia:Dorsal_mesentery + + + + + + + + + + + + + + + + + + + + + EMAPA:16844 + MA:0001636 + VHOG:0000215 + extrahepatic part of hepatic duct + @@ -127017,6 +197813,12 @@ + EHDAA2:0000936 + EHDAA:404 + EMAPA:16205 + MA:0000478 + SCTID:361403005 + VHOG:0000484 left dorsal aorta @@ -127053,8 +197855,113 @@ + A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex. + EHDAA2:0000984 + EHDAA:9059 + EMAPA:17304 + EMAPA:17839 + FMA:70612 + MA:0001302 + NCIT:C33641 + RETIRED_EHDAA2:0000976 + SCTID:362521008 + VHOG:0001425 lens anterior epithelium + + + + A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Arteries which arise from the abdominal aorta and distribute to most of the intestines. + BTO:0000779 + EHDAA2:0001123 + EHDAA:4343 + EMAPA:17312 + MA:0002003 + MESH:D008638 + NCIT:C52975 + SCTID:281084003 + VHOG:0001117 + Wikipedia:Mesenteric_artery + XAO:0000370 + mesenteric artery + + + + + Arteries which arise from the abdominal aorta and distribute to most of the intestines. + MESH:A07.231.114.565 + Wikipedia:Mesenteric_artery + + + + + + + + + + + + + + + + + + + + + + + + + + A vein that returns blood from the intestines. + BTO:0002781 + EHDAA:4442 + EMAPA:17348 + MA:0002177 + MESH:D008642 + NCIT:C53055 + RETIRED_EHDAA2:0001125 + SCTID:304045008 + Wikipedia:Mesenteric_vein + mesenteric vein + + + + + A vein that returns blood from the intestines. + MESH:A07.231.908.670.385 + Wikipedia:Mesenteric_vein + @@ -127069,6 +197976,12 @@ + EHDAA2:0001720 + EHDAA:406 + EMAPA:16206 + MA:0000479 + SCTID:361404004 + VHOG:0000485 right dorsal aorta @@ -127084,8 +197997,54 @@ + Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo. + EHDAA2:0004714 + FMA:305915 + SCTID:362840007 extraembryonic membrane + + + + Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo. + ISBN:0073040584 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a pylorus. + EHDAA2:0001582 + EMAPA:17633 + RETIRED_EHDAA2:0001927 + pyloric region epithelium + + + + + An epithelium that is part of a pylorus. + OBOL:automatic + @@ -127110,8 +198069,16 @@ + An epithelium that is part of a anterior chamber of eyeball. + EHDAA2:0000130 anterior chamber epithelium + + + + An epithelium that is part of a anterior chamber of eyeball. + OBOL:automatic + @@ -127136,8 +198103,18 @@ + An epithelium that is part of a lens vesicle. + EHDAA2:0000987 + EMAPA:17165 + VHOG:0000532 lens vesicle epithelium + + + + An epithelium that is part of a lens vesicle. + OBOL:automatic + @@ -127162,8 +198139,21 @@ + An ectoderm that is part of a pharyngeal arch 4. + EHDAA2:0004032 + EMAPA:16762 + EMAPA:16764 + EMAPA:16768 + RETIRED_EHDAA2:0000094 + VHOG:0001095 4th arch ectoderm + + + + An ectoderm that is part of a pharyngeal arch 4. + OBOL:automatic + @@ -127188,8 +198178,21 @@ + An endoderm that is part of a pharyngeal arch 4. + EHDAA2:0004033 + EMAPA:16765 + EMAPA:16767 + EMAPA:16769 + RETIRED_EHDAA2:0000095 + VHOG:0001092 4th arch endoderm + + + + An endoderm that is part of a pharyngeal arch 4. + OBOL:automatic + @@ -127214,8 +198217,20 @@ + A mesothelium that is part of a peritoneal cavity. + BTO:0003156 + EHDAA2:0001447 + EMAPA:16139 + FMA:18147 + SCTID:34073007 peritoneal cavity mesothelium + + + + A mesothelium that is part of a peritoneal cavity. + OBOL:automatic + @@ -127236,8 +198251,16 @@ + An endothelium that is part of a right lung. + EHDAA2:0001755 right lung endothelium + + + + An endothelium that is part of a right lung. + OBOL:automatic + @@ -127258,8 +198281,54 @@ + An endothelium that is part of a left lung. + EHDAA2:0000961 left lung endothelium + + + + An endothelium that is part of a left lung. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A dorsal mesentery that is part of a midgut. + EMAPA:16722 + EMAPA:17040 + EMAPA:18671 + RETIRED_EHDAA2:0001187 + SCTID:361434009 + midgut dorsal mesentery + + + + + A dorsal mesentery that is part of a midgut. + OBOL:automatic + @@ -127290,8 +198359,18 @@ + An anatomical cavity that is part of a lens vesicle. + EHDAA2:0000986 + EMAPA:17164 + VHOG:0000531 lens vesicle cavity + + + + An anatomical cavity that is part of a lens vesicle. + OBOL:automatic + @@ -127316,8 +198395,20 @@ + Mesenchyme that is part of a pharyngeal arch 4. + EHDAA2:0000096 + EHDAA:1677 + EMAPA:16770 + FMA:295702 + VHOG:0001052 4th arch mesenchyme + + + + Mesenchyme that is part of a pharyngeal arch 4. + OBOL:automatic + @@ -127343,8 +198434,96 @@ + Mesenchyme that is part of a optic eminence. + EHDAA:942 + EMAPA:16324 + RETIRED_EHDAA2:0001310 + VHOG:0001073 optic eminence mesenchyme + + + + Mesenchyme that is part of a optic eminence. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery of duodenum that is part of a foregut. + EHDAA2:0000564 + foregut duodenum mesentery + + + + + A mesentery of duodenum that is part of a foregut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery of duodenum that is part of a midgut. + EHDAA2:0001193 + midgut duodenum mesentery + + + + + A mesentery of duodenum that is part of a midgut. + OBOL:automatic + @@ -127370,8 +198549,18 @@ + A venous system that is part of a hindbrain. + EHDAA2:0000776 + EMAPA:18632 + VHOG:0001322 hindbrain venous system + + + + A venous system that is part of a hindbrain. + OBOL:automatic + @@ -127396,6 +198585,7 @@ + BILA:0000139 chemosensory system @@ -127419,6 +198609,11 @@ + EHDAA2:0000474 + EMAPA:31862 + EMAPA:31863 + FMA:296719 + VHOG:0000616 extraembryonic mesoderm @@ -127446,8 +198641,17 @@ + A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme. + TAO:0001453 + ZFA:0001453 pectoral appendage field + + + + A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme. + OBOL:automatic + @@ -127481,8 +198685,15 @@ + A ring of cells capable of forming a limb or paired fin[Gilbert,modified]. paired limb/fin field + + + + A ring of cells capable of forming a limb or paired fin[Gilbert,modified]. + ISBN:9780878932504 + @@ -127503,8 +198714,21 @@ + The outermost layer of a blood vessel, composed mainly of fibrous tissue. + BTO:0002010 + EMAPA:36299 + NCIT:C33818 + SCTID:61066005 + Wikipedia:Tunica_externa_(vessels) tunica adventitia of blood vessel + + + + The outermost layer of a blood vessel, composed mainly of fibrous tissue. + ISBN:0073040584 + Wikipedia:Tunica_externa_(vessels) + @@ -127530,8 +198754,20 @@ + A tunica intima that is part of a artery. + EMAPA:36293 + EV:0100028 + FMA:14272 + SCTID:40022005 + galen:IntimaOfArtery tunica intima of artery + + + + A tunica intima that is part of a artery. + OBOL:automatic + @@ -127545,9 +198781,19 @@ - + An outermost connective tissue covering of an organ, vessel, or other structure[WP]. + BTO:0002010 + FMA:45635 + SCTID:30180000 + Wikipedia:Adventitia adventitia + + + + An outermost connective tissue covering of an organ, vessel, or other structure[WP]. + Wikipedia:Adventitia + @@ -127572,8 +198818,19 @@ + Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves. + AAO:0010438 + TAO:0001736 + VHOG:0001760 + ZFA:0005386 bone foramen + + + + Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves. + TAO:curator + @@ -127598,11 +198855,16 @@ - - - + An acellular anatomical structure that is the bounding layer of a anatomical structure. + FMA:63871 acellular membrane + + + + An acellular anatomical structure that is the bounding layer of a anatomical structure. + OBOL:automatic + @@ -127640,8 +198902,22 @@ + An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. + AAO:0010596 + FMA:63872 + GAID:915 + NCIT:C13191 + SCTID:68989006 + Wikipedia:Basement_membrane basement membrane of epithelium + + + + An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. + Wikipedia:Basement_membrane + http://orcid.org/0000-0002-6601-2165 + @@ -127656,8 +198932,18 @@ + Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle. + FMA:13087 + NCIT:C34027 + SCTID:119203005 section of aorta + + + + Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle. + ncithesaurus:Aortic_Segment + @@ -127684,8 +198970,47 @@ + The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. + AAO:0011029 + BTO:0004673 + EHDAA:402 + EMAPA:18606 + SCTID:338637006 + TAO:0000014 + VHOG:0000264 + Wikipedia:Dorsal_aorta + XAO:0000051 + ZFA:0000014 dorsal aorta + + + + The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. + GO:0035907 + https://sourceforge.net/p/geneontology/ontology-requests/8525/ + + + + + + + + + In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]. + FMA:45628 + MESH:D011168 + NCIT:C33344 + SCTID:362063001 + Wikipedia:Portal_venous_system + portal system + + + + + In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]. + Wikipedia:Portal_venous_system + @@ -127693,11 +199018,53 @@ + BIRNLEX:2665 + FMA:62420 + MA:0003080 + SCTID:278748001 spinal cord segment + + + + + + + + + + + + + + + + + + + + + + A spinal cord segment that adjacent_to a caudal region. + FMA:256635 + MA:0003084 + SCTID:278753006 + neuronames:1656 + for spinal cord segments, we treat coccygeal/caudal as synonyms - we only differentiate where bone is concerned + caudal segment of spinal cord + + + + + A spinal cord segment that adjacent_to a caudal region. + OBOL:automatic + + + + @@ -127709,8 +199076,18 @@ + A delimited region of dense mesenchyme within looser mesenchyme. + AEO:0000148 + EHDAA2_RETIRED:0003148 + EHDAA:8979 developing mesenchymal condensation + + + + A delimited region of dense mesenchyme within looser mesenchyme. + AEO:0000148 + @@ -127730,8 +199107,20 @@ + Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes. + AEO:0000147 + EHDAA2_RETIRED:0003147 + EMAPA:32731 + VSAO:0000092 + XAO:0004022 cartilaginous condensation + + + + Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes. + GO:curator + @@ -127768,6 +199157,8 @@ + AEO:0000149 + EHDAA2_RETIRED:0003149 pre-muscle condensation @@ -127790,8 +199181,19 @@ + A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts. + AEO:0000150 + EHDAA2:0003150 + EMAPA:32736 pre-cartilage condensation + + + + A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts. + AEO:0000150 + AEO:JB + @@ -127811,8 +199213,52 @@ + The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip. + EHDAA2:0001061 + EHDAA:5871 + EMAPA:17355 + FMA:293051 + NCIT:C34204 + Wikipedia:Mandibular_prominence mandibular prominence + + + + The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip. + ISBN:0-683-40008-8 + MP:0010939 + + + + + + + + + + + + + + + The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw. + EHDAA2:0001070 + EHDAA:5877 + EMAPA:17359 + FMA:293049 + NCIT:C34206 + SCTID:346355001 + Wikipedia:Maxillary_prominence + maxillary prominence + + + + + The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw. + ISBN:0-683-40008-8 + MP:0010940 + @@ -127826,8 +199272,24 @@ + Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles. + AAO:0010199 + BTO:0004675 + FMA:49187 + SCTID:362618001 + TAO:0001414 + XAO:0003173 + ZFA:0001414 + neuronames:2431 occipital region + + + + Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles. + TAO:0001414 + UBERONREF:0000007 + @@ -127847,8 +199309,19 @@ + Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]. + FMA:9689 + SCTID:362890006 + See notes for serous membrane serous sac + + + + Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]. + FMA:9689 + https://github.com/obophenotype/uberon/issues/86 + @@ -127868,8 +199341,16 @@ + Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]. + FMA:69065 endo-epithelium + + + + Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]. + FMA:69065 + @@ -127895,9 +199376,46 @@ - + Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. + AAO:0000963 + EMAPA:17214 + MA:0000308 + NCIT:C32172 + SCTID:361725000 + VSAO:0000056 + Wikipedia:Axial_skeleton + XAO:0004011 axial skeleton plus cranial skeleton + + + + Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. + FMA:71221 + VSAO:0000056 + Wikipedia:Axial_skeleton + https://github.com/obophenotype/uberon/issues/44 + https://github.com/obophenotype/uberon/wiki/The-axial-skeleton + + + + + + + + + + + + + + + + EFO:0003677 + TAO:0001321 + ZFA:0001321 + neurocranial trabecula + @@ -127928,8 +199446,16 @@ + An outflow tract that is part of a cardiac atrium. + FMA:14141 outflow tract of atrium + + + + An outflow tract that is part of a cardiac atrium. + OBOL:automatic + @@ -127966,8 +199492,18 @@ + Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk. + FMA:7216 + NCIT:C61368 + SCTID:244379003 outflow part of right ventricle + + + + Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk. + MP:0010428 + @@ -127992,8 +199528,18 @@ + Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta. + FMA:9473 + SCTID:264070001 + Wikipedia:Aortic_vestibule outflow part of left ventricle + + + + Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta. + MP:0010429 + @@ -128018,8 +199564,17 @@ + Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA]. + FMA:9550 outflow part of right atrium + + + + Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA]. + FMA:9550 + FMA:FMA + @@ -128044,8 +199599,16 @@ + An outflow tract of atrium that is part of a left atrium. + FMA:9551 outflow part of left atrium + + + + An outflow tract of atrium that is part of a left atrium. + OBOL:automatic + @@ -128066,8 +199629,18 @@ + The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium. + FMA:9236 + SCTID:277693004 + Wikipedia:Crista_terminalis crista terminalis + + + + The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium. + MP:0010495 + @@ -128099,8 +199672,15 @@ + The laminar structure of the heart. heart layer + + + + The laminar structure of the heart. + MP:0010545 + @@ -128132,8 +199712,65 @@ + Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation. + MESH:D003331 + Wikipedia:Coronary_circulation coronary vessel + + + + Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation. + MP:0010551 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The supporting bundles of muscular fibers lining the walls of the atrial myocardium. + ZFA:0005810 + atrium myocardial trabecula + + + + + The supporting bundles of muscular fibers lining the walls of the atrial myocardium. + MP:0010581 + ZFA:0005810 + @@ -128175,8 +199812,18 @@ + The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve. + FMA:7136 + SCTID:280151006 + Wikipedia:Atrioventricular_septum atrioventricular septum + + + + The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve. + MP:0010592 + @@ -128208,8 +199855,20 @@ + The paired arteries that carry blood to the yolk sac from the dorsal aorta. + EHDAA2:0002208 + EMAPA:16207 + Wikipedia:Vitelline_arteries + Development notes:; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult[MP:0010664] vitelline artery + + + + The paired arteries that carry blood to the yolk sac from the dorsal aorta. + MP:0010664 + Wikipedia:Vitelline_arteries + @@ -128223,8 +199882,17 @@ + Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. + Wikipedia:Skin_appendage integumentary adnexa + + + + Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. + http://code.google.com/p/caro2/issues/detail?id=5 + http://orcid.org/0000-0002-6601-2165 + @@ -128260,6 +199928,276 @@ + + + + + + + + + + + + + + + + + + + + + + A bone that is part of a post-anal tail. + EMAPA:18042 + MA:0000696 + bone of tail + + + + + A bone that is part of a post-anal tail. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this. + XAO:0000087 + caudal region + + + + + Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + That portion of the spine comprising the cervical vertebrae. The neck area of the spine. + AAO:0000092 + BTO:0004148 + EHDAA2:0000238 + EHDAA:5051 + EMAPA:17215 + FMA:24138 + MA:0003154 + NCIT:C69313 + SCTID:260488005 + cervical region of vertebral column + + + + + That portion of the spine comprising the cervical vertebrae. The neck area of the spine. + http://medical-dictionary.thefreedictionary.com/ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + That part of the spine comprising the thoracic vertebrae. + BTO:0004150 + EHDAA:5063 + EMAPA:17396 + FMA:9140 + MA:0003155 + NCIT:C69315 + SCTID:243931006 + thoracic region of vertebral column + + + + + That part of the spine comprising the thoracic vertebrae. + http://medical-dictionary.thefreedictionary.com/ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae. + AAO:0000082 + EMAPA:18043 + MA:0003158 + caudal region of vertebral column + + + + + Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae. + UBERONREF:0000006 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A collection of all skeletal elements in some subdivision of the vertebral column. + FMA:16201 + subdivision of vertebral column + + + + + A collection of all skeletal elements in some subdivision of the vertebral column. + https://orcid.org/0000-0002-6601-2165 + + + + @@ -128298,8 +200236,22 @@ + The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions. + CALOHA:TS-2409 + EHDAA2:0000136 + EHDAA:2592 + EMAPA:16827 + VHOG:0000502 + Wikipedia:Aorticopulmonary_septum aortico-pulmonary spiral septum + + + + The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions. + MP:0010650 + Wikipedia:Aorticopulmonary_septum + @@ -128343,8 +200295,22 @@ + The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx. + EHDAA2:0000189 + EHDAA:536 + EMAPA:16259 + FMA:313607 + SCTID:361412007 + VHOG:0000380 + Wikipedia:Buccopharyngeal_membrane buccopharyngeal membrane + + + + The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx. + MP:0012521 + @@ -128358,11 +200324,145 @@ + EHDAA:1267 + EMAPA:16342 + RETIRED_EHDAA2:0000268 common atrial chamber + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0000456 + EHDAA:8363 + EMAPA:18023 + FMA:312597 + ethmoid bone primordium + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical junctions that overlaps the foregut and midgut. + EHDAA2:0000569 + EHDAA:526 + EMAPA:16363 + VHOG:0000291 + foregut-midgut junction + + + + + An anatomical junctions that overlaps the foregut and midgut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0000577 + EHDAA:9540 + EMAPA:18017 + FMA:312589 + tetrapod frontal bone primordium + + + + @@ -128379,8 +200479,25 @@ + The embryonic precursor of the brain. + BAMS:Enc + BTO:0004726 + EFO:0003431 + EHDAA:300 + EHDAA:830 + EMAPA:16089 + FMA:312967 + RETIRED_EHDAA2:0000591 + TAO:0000146 + ZFA:0000146 future brain + + + + The embryonic precursor of the brain. + NLX:94995 + @@ -128419,8 +200536,18 @@ + A tendon that has the potential to develop into a central tendon. + EHDAA2:0000593 + EHDAA:4118 + EMAPA:25035 future central tendon + + + + A tendon that has the potential to develop into a central tendon. + OBOL:automatic + @@ -128446,11 +200573,69 @@ + EFO:0003438 + EHDAA2:0000674 + EHDAA:898 + EMAPA:16092 + EMAPA:16755 + TAO:0000417 + ZFA:0000417 future spinal cord + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops. + EHDAA2:0000700 + EHDAA:3047 + EMAPA:16713 + XAO:0004205 + gallbladder primordium + + + + + A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops. + ISBN:0815318960 + XAO:0004205 + + + + @@ -128488,8 +200673,19 @@ + An anatomical junctions that overlaps the mouth and foregut. + EHDAA:534 + EMAPA:16258 + RETIRED_EHDAA2:0001205 + VHOG:0000592 mouth-foregut junction + + + + An anatomical junctions that overlaps the mouth and foregut. + OBOL:automatic + @@ -128506,8 +200702,20 @@ + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. + EHDAA2:0001278 + EHDAA:264 + EMAPA:16101 + NCIT:C34231 + VHOG:0001212 notochordal plate + + + + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. + VHOG:0001212 + @@ -128527,8 +200735,60 @@ + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. + EHDAA2:0001279 + EHDAA:224 + EMAPA:16102 + FMA:293135 + NCIT:C34232 + VHOG:0001213 + The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. notochordal process + + + + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. + http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/05embryonicperiod.htm + + + + + + + + + + + + + + + + + + + + + + + + + + + Either of two openings transmitting nerves and blood vessels to or from the orbit. + EHDAA2:0001328 + EHDAA:10648 + EMAPA:18717 + SCTID:280546005 + orbital fissure + + + + + Either of two openings transmitting nerves and blood vessels to or from the orbit. + http://www.merriam-webster.com/medical/orbital%20fissure + @@ -128576,8 +200836,21 @@ + Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity. + EHDAA2:0001481 + EHDAA:4128 + EMAPA:17707 + SCTID:361413002 + VHOG:0001505 pleuroperitoneal canal + + + + Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity. + ISBN:0124020607 + VHOG:0001505 + @@ -128603,8 +200876,61 @@ + Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle. + EHDAA2:0001531 + EMAPA:16350 + FMA:71006 + NCIT:C34160 + SCTID:361524003 + TAO:0002231 + Wikipedia:Embryonic_ventricle + ZFA:0001719 + The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum[WP] future cardiac ventricle + + + + Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle. + ZFA:0001719 + + + + + + + + + + + + + + + + + + + + + + + + + A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]. + EHDAA2:0001904 + EHDAA:3003 + EMAPA:18535 + XAO:0000326 + spleen primordium + + + + + A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]. + ISBN:0123747295 + MP:0011263 + @@ -128630,6 +200956,10 @@ + EHDAA:924 + EMAPA:16663 + RETIRED_EHDAA2:0002089 + See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/13 and https://github.com/obophenotype/uberon/issues/693 -- consider merging into trigeminal ganglion, as this complicates the model future trigeminal ganglion @@ -128667,8 +200997,20 @@ + A segment of the eyeball that is filled with refractive media. + BTO:0002085 + FMA:58071 + MA:0002459 + NCIT:C32301 + SCTID:280540004 chamber of eyeball + + + + A segment of the eyeball that is filled with refractive media. + http://orcid.org/0000-0002-6601-2165 + @@ -128682,8 +201024,16 @@ + Body substance in a liquid or semi-solid state in the eyeball which serves to refract light. + MA:0001911 ocular refractive media + + + + Body substance in a liquid or semi-solid state in the eyeball which serves to refract light. + http://orcid.org/0000-0002-6601-2165 + @@ -128708,8 +201058,22 @@ + Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. + BIRNLEX:20 + FMA:280556 + GAID:266 + MESH:D001826 + Wikipedia:Body_fluid + galen:BodyFluid bodily fluid + + + + Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. + MESH:A12.207 + Wikipedia:Body_fluid + @@ -128734,8 +201098,17 @@ + A nucleus of brain that is part of a brainstem. + EMAPA:32790 + MA:0000821 brainstem nucleus + + + + A nucleus of brain that is part of a brainstem. + OBOL:automatic + @@ -128761,8 +201134,19 @@ + An artery that connects two larger arteries. + EMAPA:18598 + MA:0001938 + NCIT:C52851 + Grouping for anterior and posterior communicating artery + + + + An artery that connects two larger arteries. + ncithesaurus:Communicating_Artery + @@ -128787,8 +201171,19 @@ + A lobe of lung that is part of a right lung. + EMAPA:35155 + MA:0001791 + NCIT:C48944 + SCTID:272654004 right lung lobe + + + + A lobe of lung that is part of a right lung. + OBOL:automatic + @@ -128809,8 +201204,19 @@ + System pertaining to a bronchus and alveoli. + BTO:0000136 + CALOHA:TS-1296 + EMAPA:32692 + MA:0000416 alveolar system + + + + System pertaining to a bronchus and alveoli. + BTO:0000136 + @@ -128831,6 +201237,8 @@ + EMAPA:19001 + MA:0001775 left lung alveolar system @@ -128853,6 +201261,8 @@ + EMAPA:35717 + MA:0001784 right lung alveolar system @@ -128879,8 +201289,16 @@ + A portion of organism substance that secreted_by a zone of skin. + MA:0002537 skin secretion + + + + A portion of organism substance that secreted_by a zone of skin. + OBOL:automatic + @@ -128905,8 +201323,16 @@ + A portion of organism substance that is secreted by a female reproductive gland. + MA:0002510 female reproductive gland secretion + + + + A portion of organism substance that is secreted by a female reproductive gland. + UBERON:cjm + @@ -128931,8 +201357,51 @@ + A portion of organism substance that secreted_by a respiratory system. + EMAPA:36550 + MA:0002533 + NCIT:C13722 respiratory system fluid/secretion + + + + A portion of organism substance that secreted_by a respiratory system. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A tube that is part of a excretory system. + excretory tube + + + + + A tube that is part of a excretory system. + OBOL:automatic + @@ -128946,8 +201415,18 @@ + The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. + MAT:0000049 + MESH:D010614 + MIAA:0000049 pharynx + + + + The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. + GO:0060465 + @@ -128972,8 +201451,17 @@ + Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA]. + FMA:85030 tunica media of pulmonary trunk + + + + Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA]. + FMA:85030 + FMA:FMA + @@ -129004,9 +201492,18 @@ - + A myocardium that is part of a left ventricle of a heart. + FMA:9558 + MA:0002983 + SCTID:362021000 left ventricle myocardium + + + + A myocardium that is part of a left ventricle of a heart. + http://orcid.org/0000-0002-6601-2165 + @@ -129037,9 +201534,143 @@ - + A myocardium that is part of a right ventricle of a heart. + FMA:9535 + MA:0002984 + SCTID:362020004 right ventricle myocardium + + + + A myocardium that is part of a right ventricle of a heart. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + A trabecula carnea that is part of a heart right ventricle. + FMA:7270 + SCTID:192373001 + trabecula carnea of right ventricle + + + + + A trabecula carnea that is part of a heart right ventricle. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A trabecula carnea that is part of a heart left ventricle. + FMA:7271 + SCTID:190344008 + trabecula carnea of left ventricle + + + + + A trabecula carnea that is part of a heart left ventricle. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:. + EMAPA:19159 + FMA:75383 + NCIT:C34245 + SCTID:245445008 + Wikipedia:Pectinate_line + pectinate line + + + + + The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:. + Wikipedia:Pectinate_line + @@ -129080,8 +201711,19 @@ + Presumptive structure of the blastula that will develop into endoderm. + AAO:0000471 + EFO:0003437 + TAO:0000416 + ZFA:0000416 presumptive endoderm + + + + Presumptive structure of the blastula that will develop into endoderm. + http://orcid.org/0000-0002-6601-2165 + @@ -129106,6 +201748,10 @@ + AAO:0000468 + EFO:0003439 + TAO:0000568 + ZFA:0000568 presumptive blood @@ -129136,8 +201782,20 @@ + Portion of embryonic tissue determined by fate mapping to become a structure. + AAO:0000479 + TAO:0001116 + ZFA:0001116 presumptive structure + + + + Portion of embryonic tissue determined by fate mapping to become a structure. + GOC:CVS + GOC:YMB + ZFA:0001116 + @@ -129178,8 +201836,20 @@ + Presumptive structure of the blastula that will develop into ectoderm. + AAO:0000470 + EFO:0003466 + TAO:0001376 + XAO:0004132 + ZFA:0001376 presumptive ectoderm + + + + Presumptive structure of the blastula that will develop into ectoderm. + http://orcid.org/0000-0002-6601-2165 + @@ -129220,8 +201890,50 @@ + Presumptive structure of the blastula that will develop into mesoderm. + AAO:0000476 + EFO:0003467 + TAO:0001377 + ZFA:0001377 presumptive mesoderm + + + + Presumptive structure of the blastula that will develop into mesoderm. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis. + BTO:0004838 + SCTID:86915006 + Wikipedia:Muscular_layer + muscular coat + + + + + A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis. + Wikipedia:Muscular_layer + @@ -129249,8 +201961,22 @@ + The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers. + EMAPA:17702 + FMA:58279 + NCIT:C34119 + SCTID:244943002 + VHOG:0001399 + Wikipedia:Central_tendon_of_diaphragm central tendon of diaphragm + + + + The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers. + MGI:csmith + MP:0012061 + @@ -129275,8 +202001,54 @@ + An anatomical boundary that adjacent_to a epithelium. + FMA:70997 surface of epithelium + + + + An anatomical boundary that adjacent_to a epithelium. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A vein that is part of a vertebral column. + EMAPA:18255 + FMA:76735 + MA:0002108 + SCTID:181376008 + Wikipedia:Spinal_veins + spinal vein + + + + + A vein that is part of a vertebral column. + OBOL:automatic + @@ -129318,9 +202090,23 @@ - + The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm. + EFO:0001403 + FMA:58342 + GAID:896 + MESH:D016850 + SCTID:63716004 + Wikipedia:Corneal_limbus + ZFA:0005570 + This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343 corneo-scleral junction + + + + The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm. + MP:0013477 + @@ -129345,8 +202131,18 @@ + An epithelium that is composed primarily of secretory cells. + BTO:0002991 + NCIT:C43370 + NCIT:C45715 glandular epithelium + + + + An epithelium that is composed primarily of secretory cells. + http://orcid.org/0000-0002-6601-2165 + @@ -129372,8 +202168,51 @@ + Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand. + AAO:0000027 + FMA:63897 + SCTID:68477002 areolar connective tissue + + + + Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand. + FMA:63897 + + + + + + + + + + + + + + + + + + + + + + + + + + The supporting bundles of muscular fibers lining the walls of the atria[MP]. + trabecula carnea of atrium + + + + + The supporting bundles of muscular fibers lining the walls of the atria[MP]. + MP:0010581 + @@ -129404,8 +202243,17 @@ + An anatomical space that surrounded_by a trachea. + FMA:7469 + SCTID:197486000 lumen of trachea + + + + An anatomical space that surrounded_by a trachea. + OBOL:automatic + @@ -129443,8 +202291,46 @@ + A subdivision of a the reproductive tract in a female organism that is the site of embryo development. + TADS:0000421 + WBbt:0006760 uterus or analog + + + + A subdivision of a the reproductive tract in a female organism that is the site of embryo development. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + Vein that is central to a lobule in the liver. + FMA:17544 + NCIT:C32281 + SCTID:272023004 + TAO:0005168 + Wikipedia:Central_veins_of_liver + ZFA:0005168 + central vein of liver + + + + + Vein that is central to a lobule in the liver. + ZFA:0005168 + @@ -129458,8 +202344,49 @@ + A furrow or an incomplete tube. + AEO:0000161 + EHDAA2_RETIRED:0003161 + Surface groove is modelled as immaterial - see https://github.com/obophenotype/uberon/issues/2667 for discussion surface groove + + + + A furrow or an incomplete tube. + AEO:0000161 + AEO:JB + https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/4 + + + + + + + + + + + + + + + + + + + + + The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus. + WBbt:0005773 + terminal part of digestive tract + + + + + The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus. + http://orcid.org/0000-0002-6601-2165 + @@ -129484,8 +202411,53 @@ + A vasculature that is part of a organ. + FMA:74612 vasculature of organ + + + + A vasculature that is part of a organ. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A vasculature that is part of a liver. + EHDAA2:0003454 + EMAPA:35501 + FMA:73748 + vasculature of liver + + + + + A vasculature that is part of a liver. + OBOL:automatic + @@ -129511,8 +202483,27 @@ + A head mesenchyme that develops_from a mesoderm. + AAO:0011051 + EFO:0003337 + EFO:0003603 + EHDAA2:0001118 + EHDAA:655 + EMAPA:16099 + EMAPA_RETIRED:16270 + FMA:293859 + TAO:0000998 + VHOG:0000185 + XAO:0000053 + ZFA:0000998 head mesenchyme from mesoderm + + + + A head mesenchyme that develops_from a mesoderm. + OBOL:automatic + @@ -129537,8 +202528,19 @@ + Mesenchyme that is part of a mandibular prominence. + EHDAA2:0001062 + EHDAA:5861 + EHDAA:5873 + EMAPA:17357 mandibular process mesenchyme + + + + Mesenchyme that is part of a mandibular prominence. + OBOL:automatic + @@ -129569,8 +202571,18 @@ + An anatomical space that surrounded_by a digestive tract. + BTO:0000349 + EMAPA:32908 + FMA:45677 lumen of digestive tract + + + + An anatomical space that surrounded_by a digestive tract. + OBOL:automatic + @@ -129595,8 +202607,18 @@ + An epithelium that is part of a lip. + BTO:0004468 + TAO:0005334 + ZFA:0005334 lip epithelium + + + + An epithelium that is part of a lip. + OBOL:automatic + @@ -129621,8 +202643,19 @@ + An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. + BTO:0002072 + NCIT:C12848 + SCTID:40118003 + Wikipedia:Squamous_epithelium squamous epithelium + + + + An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. + Wikipedia:Squamous_epithelium + @@ -129642,8 +202675,19 @@ + Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]. + FMA:45563 + NCIT:C13180 + Wikipedia:Stratified_squamous_epithelium stratified squamous epithelium + + + + Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]. + FMA:45563 + Wikipedia:Stratified_squamous_epithelium + @@ -129663,8 +202707,20 @@ + A squamous epithelium that is part of a esophagus. + BTO:0003635 + CALOHA:TS-1250 + EMAPA:35324 + MA:0001567 + NCIT:C49222 esophagus squamous epithelium + + + + A squamous epithelium that is part of a esophagus. + OBOL:automatic + @@ -129684,8 +202740,17 @@ + A squamous epithelium that is part of a stomach. + EMAPA:35824 + MA:0001611 stomach squamous epithelium + + + + A squamous epithelium that is part of a stomach. + OBOL:automatic + @@ -129717,8 +202782,18 @@ + A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands. + EMAPA:35814 + FMA:63458 + MA:0002784 stomach glandular epithelium + + + + A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands. + ISBN:0073040584 + @@ -129738,8 +202813,17 @@ + Any gland that is part of the digestive system. + AAO:0000130 + BTO:0000345 digestive system gland + + + + Any gland that is part of the digestive system. + UBERON:cjm + @@ -129759,8 +202843,17 @@ + Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]. + FMA:64800 + NCIT:C13182 glandular columnar epithelium + + + + Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]. + FMA:64800 + @@ -129780,6 +202873,7 @@ + FMA:66809 glandular cuboidal epithelium @@ -129806,8 +202900,17 @@ + Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region. + EMAPA:27167 + MA:0001614 stomach glandular region mucosa + + + + Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region. + http://orcid.org/0000-0002-6601-2165 + @@ -129838,8 +202941,18 @@ + Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue. + CALOHA:TS-0682 + FMA:62410 + SCTID:309045006 sensory epithelium + + + + Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue. + BTO:0000314 + @@ -129871,9 +202984,22 @@ - + The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis. + CALOHA:TS-1246 + EMAPA:28880 + FMA:18626 + MA:0002991 + NCIT:C33638 + SCTID:259306002 + Wikipedia:Stroma_of_ovary ovary stroma + + + + The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis. + Wikipedia:Stroma_of_ovary + @@ -129905,8 +203031,19 @@ + The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]. + EFO:0003709 + TAO:0005077 + ZFA:0005077 vascular cord + + + + The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]. + GO:0072360 + ZFA:0005077 + @@ -129926,8 +203063,16 @@ + A capillary that is part of the coronary system. + ZFA:0005813 coronary capillary + + + + A capillary that is part of the coronary system. + http://orcid.org/0000-0002-6601-2165 + @@ -129935,8 +203080,21 @@ + A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n. + BILA:0000010 + CARO:0001002 + EHDAA2_RETIRED:0003192 + FMA:24137 + NCIT:C34022 + Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism. anatomical surface + + + + A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n. + CARO:0001002 + @@ -129969,8 +203127,26 @@ + The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. + AAO:0011021 + BILA:0000051 + EFO:0000315 + EHDAA2:0000214 + EHDAA:385 + FMA:293143 + SCTID:360387000 + VHOG:0001641 + XAO:0000235 cardiogenic splanchnic mesoderm + + + + The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. + XAO:0000235 + http://www.drugs.com/dict/cardiogenic-mesoderm.html + https://github.com/obophenotype/insect_neuroanatomy_ontology/issues/7 + @@ -130005,8 +203181,16 @@ + Organism at the cleavage stage. + BILA:0000058 cleaving embryo + + + + Organism at the cleavage stage. + OBOL:automatic + @@ -130049,6 +203233,9 @@ + BILA:0000084 + NCIT:C34268 + SCTID:360394002 presumptive gut @@ -130075,6 +203262,7 @@ + BILA:0000142 mechanosensory system @@ -130090,8 +203278,18 @@ + Cranial neural crest that migrates into the mandibular arch. + TAO:0007064 + XAO:0000024 + ZFA:0007064 mandibular neural crest + + + + Cranial neural crest that migrates into the mandibular arch. + ZFA:0007064 + @@ -130122,8 +203320,18 @@ + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. + TADS:0000147 + http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg + Gene notes: Bmp, Nkx, Gata primary circulatory organ + + + + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. + GO:0007507 + @@ -130148,8 +203356,20 @@ + Ganglion which is located in the trunk. + EFO:0000901 + MAT:0000344 + MIAA:0000344 + TAO:0001573 + ZFA:0001573 trunk ganglion + + + + Ganglion which is located in the trunk. + ZFIN:curator + @@ -130163,8 +203383,244 @@ + An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. + EFO:0003497 + TAO:0000131 + ZFA:0000131 neural keel + + + + An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. + ZFIN:ZDB-PUB-961014-576 + + + + + + + + + + + + + + + An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail. + EMAPA:16748 + FMA:85540 + embryonic post-anal tail + + + + + An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that surrounded_by a midgut. + EMAPA:18377 + FMA:54366 + lumen of midgut + + + + + An anatomical cavity that surrounded_by a midgut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that surrounded_by a hindgut. + EMAPA:18396 + FMA:54367 + lumen of hindgut + + + + + An anatomical cavity that surrounded_by a hindgut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that surrounded_by a anal canal. + EMAPA:18836 + FMA:17357 + lumen of anal canal + + + + + An anatomical cavity that surrounded_by a anal canal. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that surrounded_by a colon. + EMAPA:18945 + FMA:18374 + SCTID:362156004 + lumen of colon + + + + + An anatomical cavity that surrounded_by a colon. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A lamina propria that is part of a colonic mucosa. + EMAPA:27395 + FMA:15657 + MA:0003196 + SCTID:113284008 + lamina propria of mucosa of colon + + + + + A lamina propria that is part of a colonic mucosa. + OBOL:automatic + @@ -130189,8 +203645,19 @@ + A mesothelium that is part of a serous pericardium. + BTO:0003157 + EMAPA:16133 + FMA:18149 + SCTID:67300002 mesothelium of serous pericardium + + + + A mesothelium that is part of a serous pericardium. + OBOL:automatic + @@ -130234,8 +203701,18 @@ + The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis. + CALOHA:TS-0085 + FMA:21426 + Wikipedia:Bone_marrow#Stroma stroma of bone marrow + + + + The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis. + Wikipedia:Bone_marrow#Stroma + @@ -130268,9 +203745,19 @@ - + The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells. + FMA:7393 + NCIT:C117875 + SCTID:361384001 + Wikipedia:Tracheobronchial_tree tracheobronchial tree + + + + The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells. + Wikipedia:Tracheobronchial_tree + @@ -130278,8 +203765,15 @@ + The vasculature consisting of brachiocephalic arteries and veins. brachiocephalic vasculature + + + + The vasculature consisting of brachiocephalic arteries and veins. + http://orcid.org/0000-0002-6601-2165 + @@ -130305,8 +203799,22 @@ + Mesenchyme that develops_from a cranial neural crest. + EFO:0003572 + EHDAA2:0000735 + EMAPA:16169 + EMAPA:16271 + EMAPA_RETIRED:16271 + TAO:0000787 + ZFA:0000787 mesenchyme derived from head neural crest + + + + Mesenchyme that develops_from a cranial neural crest. + OBOL:automatic + @@ -130332,8 +203840,19 @@ + Mesenchyme that develops_from a trunk neural crest. + EHDAA2:0002093 + EMAPA:16182 + TAO:0000999 + ZFA:0000999 mesenchyme derived from trunk neural crest + + + + Mesenchyme that develops_from a trunk neural crest. + OBOL:automatic + @@ -130347,11 +203866,33 @@ + EHDAA2:0000031 + EHDAA:583 + EMAPA:16382 + VHOG:0000510 1st arch mandibular component + + + + + + + + + + + EHDAA2:0000038 + EHDAA:595 + EMAPA:16388 + 1st arch maxillary component + + + + @@ -130373,8 +203914,20 @@ + A tunica media that is part of a artery. + EMAPA:36294 + EV:0100029 + FMA:14273 + NCIT:C49321 + SCTID:84300001 tunica media of artery + + + + A tunica media that is part of a artery. + OBOL:automatic + @@ -130405,8 +203958,19 @@ + A tunica adventitia that is part of a artery. + EMAPA:36295 + EV:0100030 + FMA:14274 + SCTID:113261001 tunica adventitia of artery + + + + A tunica adventitia that is part of a artery. + OBOL:automatic + @@ -130431,8 +203995,19 @@ + A tunica adventitia that is part of a vein. + EMAPA:36310 + EV:0100034 + FMA:14355 + SCTID:13202006 tunica adventitia of vein + + + + A tunica adventitia that is part of a vein. + OBOL:automatic + @@ -130458,8 +204033,19 @@ + A tunica intima that is part of a vein. + EMAPA:36308 + EV:0100032 + FMA:14353 + SCTID:2436009 tunica intima of vein + + + + A tunica intima that is part of a vein. + OBOL:automatic + @@ -130484,8 +204070,19 @@ + A tunica media that is part of a vein. + EMAPA:36309 + EV:0100033 + FMA:14354 + SCTID:42049001 tunica media of vein + + + + A tunica media that is part of a vein. + OBOL:automatic + @@ -130510,8 +204107,17 @@ + Gray matter of the central nervous system which is a collection of clustered nuclei. + FMA:256381 + FMA:84059 nuclear complex of neuraxis + + + + Gray matter of the central nervous system which is a collection of clustered nuclei. + http://orcid.org/0000-0002-6601-2165 + @@ -130537,8 +204143,17 @@ + Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei. + FMA:72246 + SCTID:369024009 nucleus of superior olivary complex + + + + Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei. + http://orcid.org/0000-0002-6601-2165 + @@ -130564,8 +204179,17 @@ + A pre-cartilage condensation that is part of a trachea. + EHDAA2:0002070 + EHDAA:7082 trachea pre-cartilage rings + + + + A pre-cartilage condensation that is part of a trachea. + OBOL:automatic + @@ -130591,8 +204215,18 @@ + Any collection of muscles that is part of a pectoral appendage. + EFO:0003540 + TAO:0000563 + ZFA:0000563 pectoral appendage musculature + + + + Any collection of muscles that is part of a pectoral appendage. + OBOL:automatic + @@ -130617,8 +204251,17 @@ + Any collection of muscles that is part of an appendage. + TAO:0000207 + ZFA:0000207 appendage musculature + + + + Any collection of muscles that is part of an appendage. + OBOL:automatic + @@ -130655,8 +204298,17 @@ + Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle. + VSAO:0005000 pectoral appendage skeleton + + + + Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle. + VSAO:0005000 + VSAO:NI + @@ -130699,8 +204351,23 @@ + The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. + BAMS:HB + CALOHA:TS-2118 + EFO:0003440 + EHDAA2:0001630 + FMA:295640 + TAO:0000569 + Wikipedia:Rhombencephalon + ZFA:0000569 presumptive hindbrain + + + + The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. + Wikipedia:Rhombencephalon + @@ -130731,8 +204398,17 @@ + Portion of tissue that is part of the heart tube and will become the sinus venosus. + TAO:0002234 + ZFA:0001722 presumptive sinus venosus + + + + Portion of tissue that is part of the heart tube and will become the sinus venosus. + ZFA:0001722 + @@ -130769,8 +204445,17 @@ + A presumptive structure that has the potential to develop into a endocardium. + TAO:0002233 + ZFA:0001724 presumptive endocardium + + + + A presumptive structure that has the potential to develop into a endocardium. + OBOL:automatic + @@ -130801,8 +204486,19 @@ + Embryonic structure that gives rise to the midbrain hindbrain boundary. + EFO:0003446 + TAO:0001187 + XAO:0004086 + ZFA:0001187 presumptive midbrain hindbrain boundary + + + + Embryonic structure that gives rise to the midbrain hindbrain boundary. + ZFA:0001187 + @@ -130833,8 +204529,18 @@ + A presumptive structure that has the potential to develop into a presomitic mesoderm. + EFO:0003421 + TAO:0000053 + ZFA:0000053 presumptive segmental plate + + + + A presumptive structure that has the potential to develop into a presomitic mesoderm. + OBOL:automatic + @@ -130871,8 +204577,18 @@ + A presumptive structure that has the potential to develop into a neural plate. + EFO:0003424 + TAO:0000063 + ZFA:0000063 presumptive neural plate + + + + A presumptive structure that has the potential to develop into a neural plate. + OBOL:automatic + @@ -130892,8 +204608,20 @@ + The part of the blastula that has the potential to develop into a paraxial mesoderm. + EFO:0003443 + TAO:0000591 + XAO:0004134 + ZFA:0000591 presumptive paraxial mesoderm + + + + The part of the blastula that has the potential to develop into a paraxial mesoderm. + UBERON:cjm + https://github.com/obophenotype/uberon/issues/1277 + @@ -130918,8 +204646,17 @@ + A blood vessel that is part of a pectoral appendage. + TAO:0005301 + ZFA:0005301 pectoral appendage blood vessel + + + + A blood vessel that is part of a pectoral appendage. + OBOL:automatic + @@ -130944,8 +204681,17 @@ + A blood vessel that is part of a limb/fin. + TAO:0005299 + ZFA:0005299 appendage blood vessel + + + + A blood vessel that is part of a limb/fin. + OBOL:automatic + @@ -130970,8 +204716,17 @@ + A vasculature that is part of a pectoral appendage. + TAO:0005096 + ZFA:0005096 pectoral appendage vasculature + + + + A vasculature that is part of a pectoral appendage. + OBOL:automatic + @@ -130996,8 +204751,17 @@ + A vasculature that is part of a chordate pharynx. + TAO:0005003 + ZFA:0005003 pharyngeal vasculature + + + + A vasculature that is part of a chordate pharynx. + OBOL:automatic + @@ -131022,8 +204786,149 @@ + A vasculature that is part of a limb/fin. + TAO:0005095 + ZFA:0005095 appendage vasculature + + + + A vasculature that is part of a limb/fin. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans. + FMA:16012 + MA:0000721 + pancreatic lobule + + + + + A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans. + ISBN:0123813611 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A duct that collects and carries secretions of the exocrine pancreas to the intestine. + EHDAA:9194 + EMAPA:32952 + FMA:10419 + MA:0000124 + SCTID:181278006 + TAO:0001372 + VHOG:0000254 + Wikipedia:Pancreatic_duct + ZFA:0001372 + pancreatic duct + + + + + A duct that collects and carries secretions of the exocrine pancreas to the intestine. + GOC:cvs + GOC:ymb + Wikipedia:Pancreatic_duct + https://github.com/obophenotype/uberon/issues/1250 + https://orcid.org/0000-0002-2244-7917 + https://orcid.org/0000-0002-6601-2165 + https://orcid.org/0000-0002-9900-7880 + + + + + + + + + + + + + + + A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones. + CALOHA:TS-2212 + Wikipedia:Palate + roof of mouth + + + + + A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones. + https://orcid.org/0000-0002-6601-2165 + @@ -131065,8 +204970,21 @@ + The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. + BSA:0000073 + BTO:0000313 + HAO:0000298 + TADS:0000109 + WBbt:0005733 + Wikipedia:Epidermis_(zoology) outer epithelium + + + + The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. + GO:0008544 + @@ -131088,8 +205006,18 @@ + Outermost layer of cells surrounding the embryo. + EFO:0003425 + TAO:0000086 + ZFA:0000086 enveloping layer of ectoderm + + + + Outermost layer of cells surrounding the embryo. + http://orcid.org/0000-0002-6601-2165 + @@ -131120,8 +205048,17 @@ + A cartilage tissue that is part of a paired limb or fin. + TAO:0001543 + ZFA:0001543 paired limb/fin cartilage + + + + A cartilage tissue that is part of a paired limb or fin. + http://orcid.org/0000-0002-6601-2165 + @@ -131153,8 +205090,17 @@ + A cartilage tissue that is part of a pectoral appendage. + TAO:0000257 + ZFA:0000257 pectoral appendage cartilage tissue + + + + A cartilage tissue that is part of a pectoral appendage. + OBOL:automatic + @@ -131179,8 +205125,17 @@ + A nucleus of brain that spans a midbrain tegmentum. + FMA:258768 + ZFA:0005577 nucleus of midbrain tegmentum + + + + A nucleus of brain that spans a midbrain tegmentum. + OBOL:automatic + @@ -131205,8 +205160,16 @@ + The space within an epithelial sphere. + AEO:0000079 lumen of epithelial sac + + + + The space within an epithelial sphere. + AEO:JB + @@ -131231,8 +205194,17 @@ + A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified. + AEO:0000081 + EHDAA2:0003081 matrix-based tissue + + + + A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified. + AEO:JB + @@ -131252,8 +205224,18 @@ + An epithelial tube that is open at one end only. + AEO:0000115 + EHDAA2:0003115 epithelial sac + + + + An epithelial tube that is open at one end only. + AEO:JB + UBERONREF:0000001 + @@ -131261,8 +205243,18 @@ + An epithelial tube open at both ends that allows fluid flow. + AEO_RETIRED:0000116 + RETIRED_EHDAA2:0003116 epithelial tube open at both ends + + + + An epithelial tube open at both ends that allows fluid flow. + AEO:JB + UBERONREF:0000001 + @@ -131270,8 +205262,100 @@ + A closed epithelium with a lumen. + AEO:0000119 + EHDAA2:0003119 epithelial vesicle + + + + A closed epithelium with a lumen. + AEO:JB + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A ring of smooth muscle cells whose contraction closes the opening of the ring. + AEO:0000143 + EHDAA2:0003143 + SCTID:362915001 + smooth muscle sphincter + + + + + A ring of smooth muscle cells whose contraction closes the opening of the ring. + AEO:JB + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A ring of striated muscle cells whose contraction closes the opening of the ring. + AEO:0000144 + EHDAA2:0003144 + striated muscle sphincter + + + + + A ring of striated muscle cells whose contraction closes the opening of the ring. + AEO:JB + @@ -131285,8 +205369,17 @@ + Mesenchyme with little extracellular matrix. + AEO:0000146 + EHDAA2:0003146 dense mesenchyme tissue + + + + Mesenchyme with little extracellular matrix. + AEO:JB + @@ -131311,8 +205404,17 @@ + Mesenchymal cells that are migrating. + AEO:0000152 + EHDAA2:0003152 migrating mesenchyme population + + + + Mesenchymal cells that are migrating. + AEO:JB + @@ -131332,8 +205434,16 @@ + Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]. + FMA:64798 ciliated columnar epithelium + + + + Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]. + FMA:64798 + @@ -131358,8 +205468,15 @@ + Epithelium bearing vibratile cilia on the free surface. ciliated epithelium + + + + Epithelium bearing vibratile cilia on the free surface. + http://medical-dictionary.thefreedictionary.com/ciliated+epithelium + @@ -131390,8 +205507,19 @@ + A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. + BTO:0001338 + CALOHA:TS-0998 + FMA:66762 layer of synovial tissue + + + + A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. + BTO:0001338 + http://www.britannica.com/EBchecked/topic/578563/synovial-tissue + @@ -131416,8 +205544,16 @@ + An anatomical cavity that surrounded_by a synovial joint. + FMA:11356 synovial cavity of joint + + + + An anatomical cavity that surrounded_by a synovial joint. + OBOL:automatic + @@ -131442,8 +205578,17 @@ + Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules. + GAID:907 + MESH:D010857 pigment epithelium of eye + + + + Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules. + MP:0005200 + @@ -131469,8 +205614,17 @@ + A neural nucleus that is part of a medulla oblongata. + FMA:258772 + SCTID:304943004 nucleus of medulla oblongata + + + + A neural nucleus that is part of a medulla oblongata. + OBOL:automatic + @@ -131490,8 +205644,23 @@ + The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]. + BIRNLEX:4096 + BM:V + CALOHA:TS-2077 + DHBA:266441713 + FMA:71248 + HBA:9203 + Wikipedia:Trigeminal_nerve_nuclei + neuronames:2021 trigeminal nuclear complex + + + + The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]. + Wikipedia:Trigeminal_nerve_nuclei + @@ -131506,11 +205675,46 @@ - - - + An anatomical structure that connects two structures. + FMA:5898 + SCTID:91833003 anatomical junction + + + + An anatomical structure that connects two structures. + http://code.google.com/p/caro2/issues/detail?id=15 + + + + + + + + + + + + + + + + + + + + + A sphincter that is part of an esophagus. + SCTID:277765007 + esophageal sphincter + + + + + A sphincter that is part of an esophagus. + http://orcid.org/0000-0002-6601-2165 + @@ -131519,8 +205723,20 @@ + Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. + AEO:0000170 + EFO:0001649 + EHDAA2:0003170 + Wikipedia:Anlage_(biology) anlage + + + + Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. + FBbt:00005426 + http://flybase.org/reports/FBrf0178740.html + @@ -131535,6 +205751,12 @@ + EFO:0003626 + EHDAA2:0001457 + EHDAA:962 + TAO:0001104 + ZFA:0001104 + relation conflict: ZFA vs EHDAA2. Note EHDAA2 term renamed to 'early PA endoderm' early pharyngeal endoderm @@ -131562,8 +205784,16 @@ + A bone that is part of a reproductive organ. bone of reproductive organ + + + + A bone that is part of a reproductive organ. + OBOL:automatic + https://github.com/obophenotype/uberon/issues/1158 + @@ -131588,8 +205818,16 @@ + A gland that is part of a epidermis. + FMA:59153 epidermis gland + + + + A gland that is part of a epidermis. + OBOL:automatic + @@ -131634,8 +205872,19 @@ + Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces. + FMA:12276 + GAID:1195 + MESH:D005122 + ncithesaurus:Transudate transudate + + + + Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces. + http://medical-dictionary.thefreedictionary.com/transudate + @@ -131661,8 +205910,16 @@ + Any fluid produced by a serous gland. + Wikipedia:Serous_fluid secretion of serous gland + + + + Any fluid produced by a serous gland. + UBERON:cjm + @@ -131676,9 +205933,21 @@ - + Anatomical system that consists of all blood and lymph vessels. + BTO:0001085 + CALOHA:TS-2053 + EHDAA2:0004520 + EMAPA:35905 + MA:0002718 + NCIT:C33854 vascular system + + + + Anatomical system that consists of all blood and lymph vessels. + http://orcid.org/0000-0002-6601-2165 + @@ -131698,8 +205967,20 @@ + Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots. + CALOHA:TS-0002 + EFO:0003771 adipose tissue of abdominal region + + + + Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots. + CALOHA:paula + MGI:csmith + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/259 + @@ -131731,8 +206012,80 @@ + The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. + CALOHA:TS-2356 + EV:0100009 + FMA:280881 + MA:0000006 + NCIT:C12418 + SCTID:361355005 + WikipediaCategory:Head_and_neck + galen:HeadAndNeck craniocervical region + + + + The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton. + AAO:0010338 + MA:0000008 + NCIT:C77663 + TAO:0001117 + XAO:0003026 + ZFA:0001117 + post-anal tail + + + + + A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton. + https://orcid.org/0000-0002-6601-2165 + @@ -131769,8 +206122,56 @@ + An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). + FMA:24874 + VSAO:0000303 appendage girdle region + + + + An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesentery that is located in the peritoneum. + FMA:20570 + TAO:0005129 + XAO:0000138 + ZFA:0005129 + peritoneal mesentery + + + + + Mesentery that is located in the peritoneum. + UBERON:cjm + @@ -131795,8 +206196,17 @@ + A bone that is part of a appendage girdle region. + EMAPA:35379 + MA:0000291 girdle bone/zone + + + + A bone that is part of a appendage girdle region. + OBOL:automatic + @@ -131822,9 +206232,17 @@ - + A bone that is part of a pectoral girdle region. + EMAPA:35669 + MA:0000292 pectoral girdle bone + + + + A bone that is part of a pectoral girdle region. + OBOL:automatic + @@ -131865,8 +206283,29 @@ + A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons. + AAO:0000422 + AAO:0000754 + EFO:0000946 + EHDAA2:0001420 + FMA:24141 + MAT:0000181 + MIAA:0000181 + NCIT:C33547 + TAO:0000407 + VHOG:0001156 + VSAO:0000156 + Wikipedia:Pectoral_girdle + XAO:0003063 + ZFA:0000407 pectoral girdle skeleton + + + + A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons. + Wikipedia:Pectoral_girdle + @@ -131880,8 +206319,24 @@ + Bone element that arises as a result of intramembranous ossification. + AEO:0000085 + EHDAA2:0003085 + TAO:0001645 + VSAO:0000023 + XAO:0004014 + ZFA:0001636 membrane bone + + + + Bone element that arises as a result of intramembranous ossification. + GO_REF:0000034 + VSAO:0000023 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/267 + @@ -131918,8 +206373,24 @@ + Skeletal element that is composed of cartilage tissue and may be permanent or transient. + AAO:0011130 + CALOHA:TS-0118 + FMA:55107 + VSAO:0000000 + XAO:0004013 + ZFA:0001501 cartilage element + + + + Skeletal element that is composed of cartilage tissue and may be permanent or transient. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000000 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -131946,8 +206417,16 @@ + Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue. + FMA:20103 regular connective tissue + + + + Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue. + FMA:20103 + @@ -131971,8 +206450,24 @@ + Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts). + FMA:64781 + NCIT:C33453 + SCTID:22560007 + VSAO:0000050 + Wikipedia:Dense_regular_connective_tissue + XAO:0004030 dense regular connective tissue + + + + Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts). + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000050 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -131997,8 +206492,36 @@ + A bone that is part of a craniocervical region. + MA:0000569 bone of craniocervical region + + + + A bone that is part of a craniocervical region. + OBOL:automatic + + + + + + + + + The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid. + FMA:7477 + NCIT:C32881 + SCTID:421560006 + Wikipedia:Irregular_bone + irregular bone + + + + + The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid. + Wikipedia:Irregular_bone + @@ -132035,8 +206558,16 @@ + A skeletal joint that is part of a appendage girdle region. + MA:0001505 joint of girdle + + + + A skeletal joint that is part of a appendage girdle region. + OBOL:automatic + @@ -132061,8 +206592,53 @@ + An anatomical surface that is part of a cartilage element. + FMA:76668 surface of cartilage + + + + An anatomical surface that is part of a cartilage element. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]. + FMA:7478 + SCTID:333008005 + Wikipedia:Skeletal_pneumaticity + galen:PneumaticBone + pneumatized bone + + + + + A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]. + http://www.medilexicon.com/medicaldictionary.php?t=11303 + @@ -132087,8 +206663,16 @@ + Any muscle organ that is part of a pectoral girdle region. + FMA:37347 muscle of pectoral girdle + + + + Any muscle organ that is part of a pectoral girdle region. + OBOL:automatic + @@ -132113,8 +206697,19 @@ + Musculature system of the pharyngeal and head regions. + MA:0000571 + TAO:0000328 + ZFA:0000328 craniocervical region musculature + + + + Musculature system of the pharyngeal and head regions. + ZFA:0000328 + ZFA:curator + @@ -132134,8 +206729,18 @@ + Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax. + FMA:24217 + MA:0000028 + SCTID:362666008 dorsal thoracic segment of trunk + + + + Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax. + FMA:24217 + @@ -132161,8 +206766,17 @@ + A muscle of back that is part of a dorsal thoracic segment of trunk. + MA:0000508 + SCTID:305071003 upper back muscle + + + + A muscle of back that is part of a dorsal thoracic segment of trunk. + OBOL:automatic + @@ -132187,8 +206801,16 @@ + An endothelium that is part of a heart [Automatically generated definition]. + BTO:0004293 heart endothelium + + + + An endothelium that is part of a heart [Automatically generated definition]. + OBOL:automatic + @@ -132213,11 +206835,84 @@ + BTO:0003122 microvascular endothelium + + + + + + + + + + + + + + + + + + + + + + An intestinal villus in the duodenum. + FMA:63300 + intestinal villus of duodenum + + + + + An intestinal villus in the duodenum. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a duodenum. + CALOHA:TS-2087 + EMAPA:19078 + FMA:17231 + MA:0003208 + SCTID:66036002 + duodenal epithelium + + + + + An epithelium that is part of a duodenum. + OBOL:automatic + + + + @@ -132239,8 +206934,17 @@ + Epithelium pertaining to the trachea and bronchi. + BTO:0002925 + CALOHA:TS-1063 tracheobronchial epithelium + + + + Epithelium pertaining to the trachea and bronchi. + Dorlands_Medical_Dictionary:MerckMedicus + @@ -132271,8 +206975,21 @@ + An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers. + EHDAA2:0000444 + EHDAA:42 + EHDAA:75 + EMAPA:16050 + NCIT:C34164 + The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5. inner cell mass derived epiblast + + + + An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers. + MP:0003886 + @@ -132298,8 +207015,19 @@ + A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]. + EHDAA2:0000187 + FMA:293041 + NCIT:C34248 pharyngeal arch system + + + + A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]. + GO:0060037 + GOC:dph + @@ -132324,8 +207052,17 @@ + A head that is part of a embryo. + CALOHA:TS-0246 + FMA:293011 embryonic head + + + + A head that is part of a embryo. + OBOL:automatic + @@ -132357,8 +207094,16 @@ + A brain that develops_from a neural tube. neural tube derived brain + + + + A brain that develops_from a neural tube. + OBOL:automatic + https://github.com/obophenotype/uberon/issues/338 + @@ -132389,8 +207134,78 @@ + A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein). + EMAPA:36551 + FMA:62780 + MA:0002534 + NCIT:C13273 + Wikipedia:Pulmonary_surfactant pulmonary surfactant + + + + A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein). + Wikipedia:Pulmonary_surfactant + + + + + + + + + + + + + + + + + + + + + + + + + An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts. + AAO:0011057 + EHDAA2:0000740 + EHDAA:1530 + NCIT:C34187 + Wikipedia:Hepatic_diverticulum + XAO:0000101 + hepatic diverticulum + + + + + An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts. + MP:MP + http://www.stembook.org/node/512 + + + + + + + + + + + + + + + + + + BTO:0001642 + liver bud + @@ -132421,8 +207236,162 @@ + Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals. + EMAPA:16080 ectoplacental cavity + + + + Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals. + MP:0011207 + http://www.medilexicon.com/medicaldictionary.php?s=epamniotic+cavity + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines. + FMA:14909 + SCTID:362132003 + stomach muscularis externa + + + + + The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines. + MP:0010779 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter. + FMA:14580 + SCTID:245417002 + Wikipedia:Pyloric_canal + pyloric canal + + + + + The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter. + MP:0010791 + Wikipedia:Pyloric_canal + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]. + EMAPA:27211 + FMA:14922 + NCIT:C33431 + SCTID:70710007 + Wikipedia:Pyloric_gland + pyloric gastric gland + + + + + The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]. + MP:0010797 + Wikipedia:Pyloric_gland + @@ -132471,9 +207440,15 @@ - + The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages. pulmonary alveolar parenchyma + + + + The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages. + MP:0010901 + @@ -132494,9 +207469,22 @@ - + The largest lung subunit in which all airways participate in gas exchange, and it is composed of the parenchyma of the respiratory bronchioles, alveolar ducts, and alveoli. + FMA:7313 + NCIT:C33426 + SCTID:361365004 + Wikipedia:Acinus#The_Lungs pulmonary acinus + + + + The largest lung subunit in which all airways participate in gas exchange, and it is composed of the parenchyma of the respiratory bronchioles, alveolar ducts, and alveoli. + MP:0010911 + PMID:2014492 + PMID:3382030 + Wikipedia:Acinus#The_Lungs + @@ -132547,8 +207535,18 @@ + Any skeletal muscle organ in the hypodermis / superficial fascia. + EMAPA:18188 + MA:0003140 hypodermis skeletal muscle layer + + + + Any skeletal muscle organ in the hypodermis / superficial fascia. + ISBN:0123813611 + MP:0011157 + @@ -132568,9 +207566,18 @@ - + The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins. + FMA:45621 + Wikipedia:Pulmonary_circulation pulmonary vascular system + + + + The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins. + ISBN:0073040584 + Wikipedia:Pulmonary_circulation + @@ -132591,9 +207598,24 @@ - + Subdivision of endoskeleton derived from pharyngeal arches. + AAO:0010157 + TAO:0001216 + VHOG:0000315 + VSAO:0000149 + Wikipedia:Facial_skeleton + XAO:0003176 + ZFA:0001216 splanchnocranium + + + + Subdivision of endoskeleton derived from pharyngeal arches. + ISBN:0073040584 + Wikipedia:Facial_skeleton + https://orcid.org/0000-0002-6601-2165 + @@ -132619,8 +207641,24 @@ + Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]. + AAO:0010769 + TAO:0001590 + VSAO:0000130 + Wikipedia:Dermal_bone + XAO:0004015 + ZFA:0001590 dermal bone + + + + Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]. + GO_REF:0000034 + VSAO:0000130 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/267 + @@ -132645,8 +207683,21 @@ + Bone element that is adjacent to the notochord. + AAO:0010777 + TAO:0001639 + VSAO:0000307 + ZFA:0001629 perichordal bone + + + + Bone element that is adjacent to the notochord. + GO_REF:0000034 + VSAO:0000307 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -132672,8 +207723,19 @@ + A parenchyma that is part of a lung. + EMAPA:35522 + FMA:27360 + MA:0003168 + SCTID:201712001 lung parenchyma + + + + A parenchyma that is part of a lung. + OBOL:automatic + @@ -132693,6 +207755,8 @@ + EHDAA2:0004069 + NCIT:C34283 respiratory primordium @@ -132719,8 +207783,65 @@ + A lobe of lung that is part of a left lung. + EHDAA:2981 + NCIT:C48945 + SCTID:272655003 left lung lobe + + + + A lobe of lung that is part of a left lung. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed. + BTO:0003634 + FMA:9404 + NCIT:C32536 + SCTID:322749003 + Wikipedia:Esophageal_glands + submucosal esophageal gland + + + + + One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed. + BTO:0003634 + Wikipedia:Esophageal_glands + @@ -132735,8 +207856,23 @@ + System pertaining to blood vessels in the brain. + BTO:0003840 + EFO:0003491 + EMAPA:35186 + FMA:242007 + FMA:61935 + SCTID:362029003 + TAO:0000099 + ZFA:0000099 vasculature of brain + + + + System pertaining to blood vessels in the brain. + BTO:0003840 + @@ -132762,8 +207898,17 @@ + A zone of skin that is part of a dorsal thoracic segment of trunk. + MA:0000510 + SCTID:304890003 upper back skin + + + + A zone of skin that is part of a dorsal thoracic segment of trunk. + OBOL:automatic + @@ -132788,8 +207933,18 @@ + Vein that drains left lung and returns blood to the heart. + MA:0002207 + NCIT:C48946 + SCTID:304057004 left pulmonary vein + + + + Vein that drains left lung and returns blood to the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -132814,8 +207969,18 @@ + Vein that drains right lung and returns blood to the heart. + MA:0002208 + NCIT:C48947 + SCTID:304056008 right pulmonary vein + + + + Vein that drains right lung and returns blood to the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -132829,8 +207994,18 @@ + A gonad prior to differentiating into a definitive testis or ovary. + EHDAA2:0000716 + NCIT:C34192 + typically part of the embryo - however, in male tammar wallabies the gonads are indifferent at the neonatal stage[8827321] indifferent gonad + + + + A gonad prior to differentiating into a definitive testis or ovary. + http://www.medterms.com/script/main/art.asp?articlekey=8981 + @@ -132856,9 +208031,19 @@ - + Cranial ganglion which develops from an epibranchial placode. + TAO:0001555 + ZFA:0001555 + Epibranchial ganglia orchestrate the development of the cranial neurogenic crest epibranchial ganglion + + + + Cranial ganglion which develops from an epibranchial placode. + PMID:20133851 + ZFIN:curator + @@ -132898,8 +208083,20 @@ + Endocardium that is part of the right atrium. + EHDAA2:0000274 + FMA:7281 + NCIT:C102339 + SCTID:3194006 + VHOG:0001228 right atrium endocardium + + + + Endocardium that is part of the right atrium. + http://orcid.org/0000-0002-6601-2165 + @@ -132920,8 +208117,22 @@ + A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities. + EHDAA2:0001483 + EMAPA:17709 + NCIT:C34256 + SCTID:361429005 + VHOG:0000757 + Wikipedia:Pleuroperitoneal pleuroperitoneal membrane + + + + A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities. + Wikipedia:Pleuroperitoneal + http://medical-dictionary.thefreedictionary.com/pleuroperitoneal+membrane + @@ -132946,8 +208157,17 @@ + A vein that is part of a craniocervical region. + EHDAA2:0004542 + SCTID:32945007 craniocervical region vein + + + + A vein that is part of a craniocervical region. + OBOL:automatic + @@ -132973,8 +208193,18 @@ + Sum total of mesenchyme in the embryo. + EHDAA2:0001113 + EHDAA:177 + EMAPA:16097 entire embryonic mesenchyme + + + + Sum total of mesenchyme in the embryo. + https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/7 + @@ -132988,11 +208218,102 @@ + EMAPA:16549 + RETIRED_EHDAA2:0001454 pharyngeal region of foregut + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation. + EHDAA2:0003446 + EMAPA:18015 + sphenoid bone pre-cartilage condensation + + + + + A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A sphenoid endochondral element that is composed primarily of cartilage tissue. + EHDAA2:0001888 + sphenoid cartilage element + + + + + A sphenoid endochondral element that is composed primarily of cartilage tissue. + OBOL:automatic + + + + @@ -133003,11 +208324,61 @@ + EHDAA2:0004021 indifferent external genitalia + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a medial nasal prominence. + EHDAA2:0001077 + EMAPA:16810 + FMA:312659 + medial nasal process mesenchyme + + + + + Mesenchyme that is part of a medial nasal prominence. + OBOL:automatic + + + + + + + + + EHDAA2:0000581 + EHDAA:4776 + EMAPA:16680 + SCTID:308881001 + embryonic nasal process + + + + @@ -133029,8 +208400,17 @@ + An ectoderm that is part of a buccopharyngeal membrane. + EHDAA2:0000190 + EMAPA:16260 ectoderm of buccopharyngeal membrane + + + + An ectoderm that is part of a buccopharyngeal membrane. + OBOL:automatic + @@ -133055,8 +208435,88 @@ + An endoderm that is part of a buccopharyngeal membrane. + EHDAA2:0000191 + EMAPA:16261 endoderm of buccopharyngeal membrane + + + + An endoderm that is part of a buccopharyngeal membrane. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a foregut-midgut junction. + EHDAA2:0000570 + EMAPA:16364 + associated mesenchyme of foregut-midgut junction + + + + + Mesenchyme that is part of a foregut-midgut junction. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a foregut-midgut junction. + EHDAA2:0000575 + EMAPA:16365 + VHOG:0000430 + mesentery of foregut-midgut junction + + + + + A mesentery that is part of a foregut-midgut junction. + OBOL:automatic + @@ -133094,8 +208554,143 @@ + A portion of mesenchymal tissue associated with an individual pharyngeal arch. + EMAPA:32755 + FMA:295694 pharyngeal arch mesenchymal region + + + + A portion of mesenchymal tissue associated with an individual pharyngeal arch. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a foregut-midgut junction. + EHDAA2:0000573 + EMAPA:16564 + epithelium of foregut-midgut junction + + + + + An epithelium that is part of a foregut-midgut junction. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head. + EHDAA2:0004109 + EMAPA:16683 + FMA:295821 + mesenchyme of fronto-nasal process + + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head. + MP:0011266 + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a developing hindgut. + EHDAA2:0000780 + EMAPA:16716 + mesenchyme of hindgut + + + + + Mesenchyme that is part of a developing hindgut. + OBOL:automatic + @@ -133127,8 +208722,293 @@ + Mesenchyme that is part of a developing trachea. + EHDAA2:0002067 + EMAPA:16854 mesenchyme of trachea + + + + Mesenchyme that is part of a developing trachea. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm that is part of a anal region. + EHDAA2:0004020 + EMAPA:17177 + anal membrane endodermal component + + + + + An endoderm that is part of a anal region. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a maxillary prominence. + EHDAA2:0001071 + EMAPA:17361 + FMA:312691 + maxillary process mesenchyme + + + + + Mesenchyme that is part of a maxillary prominence. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic sinusoid that is part of a left lobe of liver. + EHDAA2:0001001 + EMAPA:18309 + VHOG:0000709 + hepatic sinusoid of left of lobe of liver + + + + + A hepatic sinusoid that is part of a left lobe of liver. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic sinusoid that is part of a right lobe of liver. + EHDAA2:0001009 + EMAPA:18316 + VHOG:0000710 + hepatic sinusoid of right of lobe of liver + + + + + A hepatic sinusoid that is part of a right lobe of liver. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm that is part of a foregut-midgut junction. + EHDAA2:0000572 + EMAPA:18403 + endoderm of foregut-midgut junction + + + + + An endoderm that is part of a foregut-midgut junction. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a intestine. + FMA:15696 + intestinal submucosa + + + + + A submucosa that is part of a intestine. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions. + FMA:72066 + NCIT:C92597 + SCTID:281699004 + trunk region of vertebral column + + + + + Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions. + UBERONREF:0000006 + @@ -133142,6 +209022,8 @@ + FMA:25054 + SCTID:22943007 subdivision of trunk @@ -133168,8 +209050,18 @@ + A sulcus limitans of neural tube that is part of a future spinal cord. + EHDAA2:0001265 + EMAPA:17584 + VHOG:0001548 spinal cord sulcus limitans + + + + A sulcus limitans of neural tube that is part of a future spinal cord. + OBOL:automatic + @@ -133200,8 +209092,17 @@ + A sulcus limitans of neural tube that is part of a future medulla oblongata. + EHDAA2:0001100 + EMAPA:17561 medulla oblongata sulcus limitans + + + + A sulcus limitans of neural tube that is part of a future medulla oblongata. + OBOL:automatic + @@ -133226,8 +209127,17 @@ + A sulcus limitans of neural tube that is part of a future metencephalon. + EHDAA2:0001161 + EMAPA:17567 metencephalon sulcus limitans + + + + A sulcus limitans of neural tube that is part of a future metencephalon. + OBOL:automatic + @@ -133252,8 +209162,16 @@ + A sulcus limitans of neural tube that is part of a future myelencephalon. + EHDAA2:0001945 myelencephalon sulcus limitans + + + + A sulcus limitans of neural tube that is part of a future myelencephalon. + OBOL:automatic + @@ -133278,6 +209196,9 @@ + EHDAA2:0001172 + EMAPA:16977 + VHOG:0000910 midbrain mantle layer @@ -133304,6 +209225,8 @@ + EMAPA:17580 + VHOG:0000911 spinal cord mantle layer @@ -133330,8 +209253,17 @@ + Mesenchyme that is part of a 1st arch mandibular component. + EHDAA2:0000034 + EMAPA:16385 1st arch mandibular mesenchyme + + + + Mesenchyme that is part of a 1st arch mandibular component. + OBOL:automatic + @@ -133356,8 +209288,18 @@ + Mesenchyme that is part of a developing left lung. + EHDAA2:0000944 + EMAPA:16730 + EMAPA:17654 left lung associated mesenchyme + + + + Mesenchyme that is part of a developing left lung. + OBOL:automatic + @@ -133382,8 +209324,17 @@ + Mesenchyme that is part of a developing right lung. + EHDAA2:0001739 + EMAPA:17662 right lung associated mesenchyme + + + + Mesenchyme that is part of a developing right lung. + OBOL:automatic + @@ -133403,8 +209354,17 @@ + A neural plate that develops_from a presumptive midbrain. + TAO:0007019 + ZFA:0007019 midbrain neural plate + + + + A neural plate that develops_from a presumptive midbrain. + OBOL:automatic + @@ -133424,8 +209384,17 @@ + A neural plate that develops_from a presumptive hindbrain. + TAO:0007022 + ZFA:0007022 hindbrain neural plate + + + + A neural plate that develops_from a presumptive hindbrain. + OBOL:automatic + @@ -133445,6 +209414,8 @@ + TAO:0007044 + ZFA:0007044 midbrain hindbrain boundary neural plate @@ -133489,8 +209460,22 @@ + A presumptive structure that has the potential to develop into a midbrain. + BAMS:MES + EFO:0003432 + EHDAA2:0000615 + EMAPA:16140 + TAO:0000148 + Wikipedia:Mesencephalon + ZFA:0000148 presumptive midbrain + + + + A presumptive structure that has the potential to develop into a midbrain. + OBOL:automatic + @@ -133510,8 +209495,18 @@ + Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles. + EHDAA2:0000736 + EHDAA:364 + EMAPA:16171 head paraxial mesoderm + + + + Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles. + PMID:21610022 + @@ -133531,16 +209526,54 @@ + EHDAA2:0002094 trunk paraxial mesoderm + + + + + + + + + + + + + + + + + + + + + + A somite that is part of a tail. + AAO:0010383 + EMAPA:16860 + XAO:0003143 + tail somite + + + + + A somite that is part of a tail. + OBOL:automatic + + + + - + EMAPA:35878 + MA:0001859 trachea non-cartilage connective tissue @@ -133568,8 +209601,17 @@ + A basement membrane that is part of a bronchus. + MA:0001832 + NCIT:C49208 bronchus basement membrane + + + + A basement membrane that is part of a bronchus. + OBOL:automatic + @@ -133601,8 +209643,17 @@ + A basement membrane that is part of a trachea. + MA:0001854 + NCIT:C49302 trachea basement membrane + + + + A basement membrane that is part of a trachea. + OBOL:automatic + @@ -133627,6 +209678,8 @@ + MA:0001987 + NCIT:C52947 artery of lip @@ -133653,8 +209706,18 @@ + Nucleus located in the midbrain. + SCTID:279285003 + TAO:0002209 + ZFA:0001665 midbrain nucleus + + + + Nucleus located in the midbrain. + ZFIN:curator + @@ -133679,8 +209742,196 @@ + Nucleus located within the hindbrain. + TAO:0002177 + ZFA:0001658 hindbrain nucleus + + + + Nucleus located within the hindbrain. + ZFIN:curator + + + + + + + + + + + + + + + EHDAA2:0004566 + EMAPA:32911 + MA:0003203 + gut mesentery + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that surrounded_by a embryonic cloaca. + EHDAA2:0004586 + embryonic cloacal lumen + + + + + An anatomical space that surrounded_by a embryonic cloaca. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that surrounded_by a rectum. + EHDAA2:0004587 + EMAPA:18388 + FMA:14598 + SCTID:259740004 + rectal lumen + + + + + An anatomical space that surrounded_by a rectum. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0001371 + dorsal pancreas + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0001393 + ventral pancreas + @@ -133717,8 +209968,21 @@ + Any endocardium that is part of the right ventricle of the heart. + EHDAA2:0002188 + EMAPA:17341 + FMA:9536 + NCIT:C102343 + SCTID:8911002 + VHOG:0001235 endocardium of right ventricle + + + + Any endocardium that is part of the right ventricle of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -133749,8 +210013,20 @@ + Any endocardium that is part of the left ventricle of the heart. + EHDAA2:0002182 + EMAPA:17338 + FMA:9559 + SCTID:191004004 + VHOG:0001233 endocardium of left ventricle + + + + Any endocardium that is part of the left ventricle of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -133775,8 +210051,15 @@ + An anatomical cavity that surrounded_by a stomodeum. stomodeal lumen + + + + An anatomical cavity that surrounded_by a stomodeum. + OBOL:automatic + @@ -133798,6 +210081,9 @@ + EHDAA2:0004621 + EMAPA:32754 + FMA:293087 entire pharyngeal arch endoderm @@ -133825,8 +210111,52 @@ + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures. + EHDAA2:0004162 + EMAPA:36438 cardiac mesenchyme + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures. + MP:0011264 + + + + + + + + + + + + + + + + + + + + + + + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas. + EFO:0002557 + EMAPA:26220 + pancreas mesenchyme + + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas. + MP:0011265 + @@ -133851,8 +210181,16 @@ + A ganglion that is part of a abdominal segment of trunk. + SCTID:280508003 abdominal ganglion + + + + A ganglion that is part of a abdominal segment of trunk. + OBOL:automatic + @@ -133901,8 +210239,18 @@ + A serous sac that has the pleura and the pleural cavity as parts. + EHDAA2:0004737 + FMA:9690 + SCTID:361996004 pleural sac + + + + A serous sac that has the pleura and the pleural cavity as parts. + https://github.com/obophenotype/uberon/issues/86 + @@ -133947,8 +210295,65 @@ + The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. + FMA:55588 + Wikipedia:Acinus glandular acinus + + + + The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. + Wikipedia:Acinus + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a embryonic cloaca. + EHDAA2:0004585 + embryonic cloacal epithelium + + + + + An epithelium that is part of a embryonic cloaca. + OBOL:automatic + @@ -133968,8 +210373,15 @@ + Branch or outpocketing of the digestive tract. digestive tract diverticulum + + + + Branch or outpocketing of the digestive tract. + https://orcid.org/0000-0002-6601-2165 + @@ -133994,6 +210406,7 @@ + galen:Diverticulum sac @@ -134021,8 +210434,21 @@ + A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland. + EMAPA:35821 + FMA:14558 + MA:0002561 + SCTID:245415005 + Wikipedia:Stomach#Sections zone of stomach + + + + A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland. + ISBN:0073040584 + Wikipedia:Stomach#Sections + @@ -134037,6 +210463,9 @@ + EFO:0003704 + TAO:0005041 + ZFA:0005041 anterior lateral plate mesoderm @@ -134073,8 +210502,18 @@ + A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract). + XAO:0004186 secondary heart field + + + + A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract). + GO:0003139 + GOC:mtg_heart + GOC:rl + @@ -134099,8 +210538,17 @@ + Mesenchyme that is part of a developing face. + EMAPA:35337 + FMA:302884 facial mesenchyme + + + + Mesenchyme that is part of a developing face. + OBOL:automatic + @@ -134108,6 +210556,8 @@ + FMA:45737 + NCIT:C12990 lobule @@ -134117,8 +210567,18 @@ + A portion of an organ, such as the liver, lung, breast, or brain. + FMA:45728 + NCIT:C13393 + UMLS:C0796494 anatomical lobe + + + + A portion of an organ, such as the liver, lung, breast, or brain. + ncithesaurus:Lobe + @@ -134133,6 +210593,8 @@ + EHDAA2:0001315 + EHDAA:1122 optic neural crest @@ -134159,8 +210621,16 @@ + A multicellular organism that existence_starts_with a post-embryonic stage. + MA:0002405 post-embryonic organism + + + + A multicellular organism that existence_starts_with a post-embryonic stage. + OBOL:automatic + @@ -134212,8 +210682,58 @@ + Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia. + EFO:0003460 + TAO:0001309 + Wikipedia:Neurogenic_placodes + XAO:0004620 + ZFA:0001309 neurogenic placode + + + + Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia. + PMID:11523831 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a pancreatic duct. + EFO:0002556 + FMA:67681 + epithelium of pancreatic duct + + + + + An epithelium that is part of a pancreatic duct. + OBOL:automatic + @@ -134244,11 +210764,16 @@ - - - + An anatomical structure that has more than one cell as a part. + CARO:0010000 multicellular anatomical structure + + + + An anatomical structure that has more than one cell as a part. + CARO:0010000 + @@ -134283,8 +210808,16 @@ + A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]. + NLXANAT:20090509 aggregate regional part of brain + + + + A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]. + NLXANAT:20090509 + @@ -134309,8 +210842,18 @@ + Mesenchyme that is part of a pharyngeal arch 6. + EHDAA2:0004076 + EMAPA:32765 + FMA:318209 6th arch mesenchyme + + + + Mesenchyme that is part of a pharyngeal arch 6. + OBOL:automatic + @@ -134330,8 +210873,18 @@ + An organ of the digestive tract that is capable of retaining and storing food. + BSA:0000123 + TADS:0000172 + TGMA:0001041 food storage organ + + + + An organ of the digestive tract that is capable of retaining and storing food. + https://orcid.org/0000-0002-6601-2165 + @@ -134356,8 +210909,51 @@ + Mesenchyme that is part of a pharyngeal arch 1. + EMAPA:16128 1st arch mesenchyme + + + + Mesenchyme that is part of a pharyngeal arch 1. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a 1st arch maxillary component. + EHDAA2:0000041 + EMAPA:16391 + 1st arch maxillary mesenchyme + + + + + Mesenchyme that is part of a 1st arch maxillary component. + OBOL:automatic + @@ -134378,8 +210974,19 @@ + The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells. + EHDAA2:0001459 + EMAPA:16550 + XAO:0004524 entire pharyngeal arch associated mesenchyme + + + + The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells. + XAO:0004524 + https://orcid.org/0000-0002-6601-2165 + @@ -134405,8 +211012,20 @@ + Gland of the epithelium lining the oral cavity. The most common are the salivary glands. + EHDAA2:0001327 + EHDAA:2181 + EMAPA:16572 + EMAPA:16723 + VHOG:0000652 oral gland + + + + Gland of the epithelium lining the oral cavity. The most common are the salivary glands. + ISBN:0073040584 + @@ -134414,8 +211033,60 @@ + An epithelium consisting of cuboidal epithelial cells. + NCIT:C32415 + Wikipedia:Cuboidal_epithelium cuboidal epithelium + + + + An epithelium consisting of cuboidal epithelial cells. + Wikipedia:Cuboidal_epithelium + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An extrahepatic bile duct that has the potential to develop into a common hepatic duct. + EHDAA2:0000595 + future common hepatic duct + + + + + An extrahepatic bile duct that has the potential to develop into a common hepatic duct. + OBOL:automatic + @@ -134458,8 +211129,16 @@ + Mesenchyme that has the potential to develop into a dermis. + EHDAA2:0000598 future dermis + + + + Mesenchyme that has the potential to develop into a dermis. + OBOL:automatic + @@ -134502,8 +211181,16 @@ + A structure that will develop into a diaphragm. + EHDAA2:0000599 future diaphragm + + + + A structure that will develop into a diaphragm. + http://orcid.org/0000-0002-6601-2165 + @@ -134534,8 +211221,16 @@ + A developing anatomical structure that has the potential to develop into a metencephalon. + EHDAA2:0000623 future metencephalon + + + + A developing anatomical structure that has the potential to develop into a metencephalon. + OBOL:automatic + @@ -134566,8 +211261,16 @@ + A developing anatomical structure that has the potential to develop into a myelencephalon. + EHDAA2:0000640 future myelencephalon + + + + A developing anatomical structure that has the potential to develop into a myelencephalon. + OBOL:automatic + @@ -134592,8 +211295,16 @@ + A gray matter that has the potential to develop into a superior salivatory nucleus. + EHDAA2:0004644 future superior salivatory nucleus + + + + A gray matter that has the potential to develop into a superior salivatory nucleus. + OBOL:automatic + @@ -134601,8 +211312,17 @@ + Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers. + EHDAA2:0004528 + FMA:83378 conducting tissue of heart + + + + Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers. + http://orcid.org/0000-0002-6601-2165 + @@ -134610,8 +211330,48 @@ + An epithelial sheet is a flat surface consisting of closely packed epithelial cells. epithelial sheet + + + + An epithelial sheet is a flat surface consisting of closely packed epithelial cells. + GO:0002011 + + + + + + + + + + + + + + + + + + + + + + + + + + A mucous secretion that is produced by glands in the epidermis. + skin mucus + + + + + A mucous secretion that is produced by glands in the epidermis. + http://orcid.org/0000-0002-6601-2165 + @@ -134642,8 +211402,93 @@ + An anatomical cavity that surrounded_by a blood vessel. + FMA:312610 + SCTID:91747007 lumen of blood vessel + + + + An anatomical cavity that surrounded_by a blood vessel. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The distal end of the tail. + MA:0002848 + XAO:0004057 + post-anal tail tip + + + + + The distal end of the tail. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + A trabecula that is part of a liver. + liver trabecula + + + + + A trabecula that is part of a liver. + GO:0060344 + OBOL:automatic + @@ -134651,8 +211496,18 @@ + A roughly circular bulge in a surface. + AEO:0000205 + EHDAA2:0003250 + FMA:82506 protuberance + + + + A roughly circular bulge in a surface. + EHDAA2:0003250 + @@ -134672,6 +211527,7 @@ + EHDAA2:0004512 aortic system @@ -134698,8 +211554,46 @@ + One of the laterally paired arteries that supply the gonads. + Wikipedia:Gonadal_artery genital artery + + + + One of the laterally paired arteries that supply the gonads. + ISBN:0073040584 + Wikipedia:Gonadal_artery + + + + + + + + + + + + + + + + + + + + + A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver. + AAO:0010225 + hepatic portal system + + + + + A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver. + ISBN:0073040584 + @@ -134707,8 +211601,53 @@ + An anatomical boundary that corresponds to some physical discontinuity. + CARO:0001004 + One might argue that all boundaries are actually fiat in the sense that there must be some fiat element at a fine enough scale of granularity. This ontology choses to ignore this issue as below the level of granularity relevant to anatomy. (DOS121102) bona-fide anatomical boundary + + + + An anatomical boundary that corresponds to some physical discontinuity. + CARO:0001004 + + + + + + + + + + + + + + + + + + + + + + + + + + A vasculature that is part of a post-anal tail. + TAO:0005037 + XAO:0004151 + ZFA:0005037 + tail vasculature + + + + + A vasculature that is part of a post-anal tail. + OBOL:automatic + @@ -134728,8 +211667,18 @@ + Multi-tissue structure that is part of the heart tube and will become the cardiac atrium. + FMA:71005 + TAO:0002228 + ZFA:0001718 future cardiac atrium + + + + Multi-tissue structure that is part of the heart tube and will become the cardiac atrium. + ZFA:0001718 + @@ -134750,8 +211699,20 @@ + The core globe-shaped component of the camera-type eye. + FMA:12513 + MIAA:0000283 + SCTID:244486005 + VHOG:0001616 + Wikipedia:Globe_(human_eye) eyeball of camera-type eye + + + + The core globe-shaped component of the camera-type eye. + UBERON:cjm + @@ -134776,8 +211737,20 @@ + An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged. + BTO:0002324 + MA:0003041 + Wikipedia:Merocrine merocrine gland + + + + An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged. + MGI:anna + MP:0013544 + Wikipedia:Merocrine + @@ -134819,8 +211792,61 @@ + Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme. + EHDAA2:0000037 1st arch mandibular mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme. + EHDAA2:0000044 + 1st arch maxillary mesenchyme from neural crest + + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme. + OBOL:automatic + @@ -134857,8 +211883,18 @@ + Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme. + EHDAA2:0000098 + EMAPA:16772 + VHOG:0000580 4th arch mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme. + OBOL:automatic + @@ -134895,8 +211931,16 @@ + Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme. + EHDAA2:0004077 6th arch mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme. + OBOL:automatic + @@ -134927,8 +211971,16 @@ + Mesenchyme that develops_from a rhombencephalon neural crest. + EHDAA2:0004423 mesenchyme from rhombencephalic neural crest + + + + Mesenchyme that develops_from a rhombencephalon neural crest. + OBOL:automatic + @@ -134959,8 +212011,50 @@ + Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme. + EMAPA:16129 1st arch mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Any anatomical space that is part of a vertebral column. + AAO:0000700 + space in vertebral column + + + + + Any anatomical space that is part of a vertebral column. + OBOL:automatic + @@ -134980,8 +212074,20 @@ + Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. + DHBA:12322 + EFO:0003567 + EHDAA2:0004375 + TAO:0000761 + ZFA:0000761 midbrain basal plate + + + + Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. + ZFA:0000761 + @@ -134996,8 +212102,17 @@ + Portion of neural tube that gives rise to the midbrain. + TAO:0007039 + ZFA:0007039 midbrain neural tube + + + + Portion of neural tube that gives rise to the midbrain. + ZFA:0007039 + @@ -135012,6 +212127,7 @@ + Wikipedia:Sclera#Histology layer of sclera @@ -135034,8 +212150,15 @@ + An endothelium that is part of a sclera. scleral endothelium + + + + An endothelium that is part of a sclera. + OBOL:automatic + @@ -135055,8 +212178,18 @@ + A stroma that is part of a sclera. + FMA:58365 + NCIT:C33652 + SCTID:368851004 substantia propria of sclera + + + + A stroma that is part of a sclera. + OBOL:automatic + @@ -135087,8 +212220,16 @@ + Mesenchyme surrounding the developing optic cup which develops into the sclera. scleral mesenchyme + + + + Mesenchyme surrounding the developing optic cup which develops into the sclera. + PMID:16496288 + https://orcid.org/0000-0002-6601-2165 + @@ -135114,8 +212255,15 @@ + An epithelium that is part of a extraembryonic structure. extraembryonic epithelium + + + + An epithelium that is part of a extraembryonic structure. + OBOL:automatic + @@ -135146,8 +212294,17 @@ + Developing anatomical structure that develops into the eyeball and associated structures. + TAO:0002201 + ZFA:0001678 immature eye + + + + Developing anatomical structure that develops into the eyeball and associated structures. + ZFA:0001678 + @@ -135173,8 +212330,15 @@ + An anatomical structure that develops from the neural crest. neural crest-derived structure + + + + An anatomical structure that develops from the neural crest. + https://orcid.org/0000-0002-6601-2165 + @@ -135199,8 +212363,15 @@ + An anatomical structure that has some part that develops from the neural crest. structure with developmental contribution from neural crest + + + + An anatomical structure that has some part that develops from the neural crest. + https://orcid.org/0000-0002-6601-2165 + @@ -135248,8 +212419,15 @@ + A skeletal element that is part of a orbital region. skeletal element of eye region + + + + A skeletal element that is part of a orbital region. + OBOL:automatic + @@ -135269,8 +212447,25 @@ + Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. + AAO:0000109 + AAO:0000971 + AAO:0010185 + TAO:0000737 + VSAO:0000049 + XAO:0003075 + ZFA:0000737 cranial skeletal system + + + + Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000049 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -135301,8 +212496,15 @@ + Mesenchyme that is part of a limb/fin bud. paired limb/fin bud mesenchyme + + + + Mesenchyme that is part of a limb/fin bud. + OBOL:automatic + @@ -135335,8 +212537,105 @@ + Mesenchyme that is part of a extraembryonic membrane. extraembryonic membrane mesenchyme + + + + Mesenchyme that is part of a extraembryonic membrane. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme. + EHDAA2:0004601 + maxillary process mesenchyme from neural crest + + + + + Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme. + EHDAA2:0004602 + maxillary process mesenchyme from head mesenchyme + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme. + OBOL:automatic + @@ -135372,8 +212671,16 @@ + Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme. + EHDAA2:0004603 mandibular process mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme. + OBOL:automatic + @@ -135409,8 +212716,55 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme. + EHDAA2:0004604 mandibular process mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme. + EHDAA2:0000043 + 1st arch maxillary mesenchyme from head mesenchyme + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme. + OBOL:automatic + @@ -135440,8 +212794,16 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme. + EHDAA2:0000036 1st arch mandibular mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme. + OBOL:automatic + @@ -135472,8 +212834,16 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme. + EMAPA:16130 1st arch mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme. + OBOL:automatic + @@ -135504,8 +212874,17 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme. + EHDAA2:0000097 + EMAPA:16771 4th arch mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme. + OBOL:automatic + @@ -135536,8 +212915,16 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme. + EHDAA2:0004078 6th arch mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme. + OBOL:automatic + @@ -135567,8 +212954,16 @@ + Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme. + Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme pharyngeal arch mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme. + OBOL:automatic + @@ -135605,8 +213000,16 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme. + Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme pharyngeal arch mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme. + OBOL:automatic + @@ -135626,8 +213029,21 @@ + Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues. + VSAO:0000037 + Wikipedia:Endoskeleton + XAO:0004026 endoskeleton + + + + Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000037 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -135635,8 +213051,21 @@ + A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification. + VSAO:0000139 + XAO:0004017 + ZFA:0005620 endochondral element + + + + A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000139 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -135650,8 +213079,21 @@ + Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements. + VSAO:0000035 + XAO:0004025 + This ontology covers metazoa, so we do not use exoskeleton as primary label, as in VSAO dermal skeleton + + + + Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000035 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -135677,8 +213119,17 @@ + The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa. + FMA:75739 + NCIT:C33428 pulmonary lobule + + + + The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa. + ncithesaurus:Pulmonary_Lobule + @@ -135692,9 +213143,16 @@ - + A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa. + FMA:7414 secondary pulmonary lobule + + + + A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa. + PMID:3259815 + @@ -135720,8 +213178,86 @@ + Epithelium composed of cells that develops from the ectoderm[FMA,modified]. + FMA:69064 ecto-epithelium + + + + Epithelium composed of cells that develops from the ectoderm[FMA,modified]. + FMA:69064 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0001384 + FMA:79793 + pancreas dorsal primordium + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0001387 + FMA:79794 + pancreas ventral primordium + @@ -135758,8 +213294,16 @@ + Mesenchyme that develops_from a somatopleure. + EHDAA2:0001120 mesenchyme from somatopleure + + + + Mesenchyme that develops_from a somatopleure. + OBOL:automatic + @@ -135796,8 +213340,115 @@ + Mesenchyme that develops_from a splanchnopleure. + EHDAA2:0001122 mesenchyme from splanchnopleure + + + + Mesenchyme that develops_from a splanchnopleure. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of the branches of the splenic artery[MP]. + MA:0000759 + NCIT:C49775 + Wikipedia:Trabecular_arteries + spleen trabecular artery + + + + + One of the branches of the splenic artery[MP]. + MP:0002354 + Wikipedia:Trabecular_arteries + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of the veins that feed the splenic vein. + MA:0000760 + NCIT:C49779 + Wikipedia:Trabecular_veins + spleen trabecular vein + + + + + One of the veins that feed the splenic vein. + MP:0002228 + Wikipedia:Trabecular_veins + @@ -135818,8 +213469,17 @@ + The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms. + EMAPA:35336 + MA:0002486 ocular surface region + + + + The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms. + MP:0013754 + @@ -135834,8 +213494,18 @@ + The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens. + FMA:76551 + SCTID:280860001 + Wikipedia:Ciliary_processes ciliary processes + + + + The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens. + Wikipedia:Ciliary_processes + @@ -135849,8 +213519,21 @@ + A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow. + FMA:7476 + NCIT:C32616 + SCTID:332907008 + Wikipedia:Flat_bone + galen:FlatBone + Examples: cranium, the ilium, sternum, rib cage, the sacrum and the scapula; the occipital, parietal, frontal, nasal, lacrimal, vomer, scapula, os coxC&, sternum, and ribs flat bone + + + + A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow. + Wikipedia:Flat_bone + @@ -135858,8 +213541,20 @@ + A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels. + FMA:45572 + NCIT:C33419 + NCIT:C49316 + Wikipedia:Pseudostratified_columnar_epithelium pseudostratified columnar epithelium + + + + A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels. + Wikipedia:Pseudostratified_columnar_epithelium + http://medical-dictionary.thefreedictionary.com/pseudostratified+epithelium + @@ -135879,8 +213574,17 @@ + Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile. + FMA:13146 + NCIT:C13181 pseudostratified ciliated columnar epithelium + + + + Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile. + NCIT:NCIT + @@ -135894,8 +213598,21 @@ + Skeletal element that forms as a replacement or substitution of another element or tissue. + VSAO:0000135 + XAO:0004016 + ZFA:0005624 replacement element + + + + Skeletal element that forms as a replacement or substitution of another element or tissue. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000135 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -135909,8 +213626,70 @@ + A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses. + MESH:D055806 + TAO:0005251 + ZFA:0005251 microcirculatory vessel + + + + A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses. + MESH:A07.231.432 + ZFA:0005251 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + An organ cavity that surrounded_by a bone. + FMA:24021 + cavity of bone organ + + + + + An organ cavity that surrounded_by a bone. + OBOL:automatic + + + + + + + + + + + + + + + FMA:24028 + pneumatic cavity of bone + @@ -135937,8 +213716,18 @@ + An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). + FMA:7182 + VSAO:0000214 appendage girdle complex + + + + An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). + https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton + https://orcid.org/0000-0002-6601-2165 + @@ -135969,8 +213758,18 @@ + Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle. + FMA:7183 + SCTID:110716002 + VSAO:0000213 pectoral complex + + + + Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle. + VSAO:0000213 + @@ -136013,8 +213812,17 @@ + The subdivision of the skeleton of either the pectoral or pelvic girdle. + AAO:0010686 + VSAO:0000302 girdle skeleton + + + + The subdivision of the skeleton of either the pectoral or pelvic girdle. + https://orcid.org/0000-0002-6601-2165 + @@ -136051,8 +213859,18 @@ + A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle). + EMAPA:35494 + MA:0000688 bone of appendage girdle complex + + + + A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle). + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + @@ -136077,8 +213895,18 @@ + A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin. + EMAPA:35933 + MA:0000612 bone of pectoral complex + + + + A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin. + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + @@ -136103,8 +213931,19 @@ + A muscle of a pectoral girdle, pectoral fin or anterior limb. + AAO:0010687 + EMAPA:32624 + FMA:9621 + MA:0000615 pectoral complex muscle + + + + A muscle of a pectoral girdle, pectoral fin or anterior limb. + https://orcid.org/0000-0002-6601-2165 + @@ -136124,8 +213963,46 @@ + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. + FMA:23879 + SCTID:129140006 + VSAO:0000042 subdivision of skeleton + + + + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + Skeletal element that forms around the notochord and is part of the vertebral column. + VHOG:0001143 + VSAO:0000184 + vertebral element + + + + + Skeletal element that forms around the notochord and is part of the vertebral column. + GO_REF:0000034 + VSAO:0000184 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/294 + @@ -136150,8 +214027,16 @@ + Any muscle organ that is part of either the head or the neck. + NCIT:C32716 craniocervical muscle + + + + Any muscle organ that is part of either the head or the neck. + http://orcid.org/0000-0002-6601-2165 + @@ -136182,8 +214067,146 @@ + A cartilage element that is part of a splanchnocranium. + EFO:0003689 + TAO:0001460 + ZFA:0001460 pharyngeal arch cartilage + + + + A cartilage element that is part of a splanchnocranium. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG]. + EFO:0003659 + TAO:0001272 + ZFA:0001272 + palatoquadrate arch + + + + + The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG]. + VHOG:0000511 + https://github.com/obophenotype/uberon/issues/153 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + EMAPA:32669 + VHOG:0000584 + vertebra cartilage element + + + + + The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + GO_REF:0000034 + VSAO:0000184 + http://dx.plos.org/10.1371/journal.pone.0051070 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + EMAPA:32671 + VHOG:0000582 + vertebra pre-cartilage condensation + + + + + The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + GO_REF:0000034 + VSAO:0000184 + http://dx.plos.org/10.1371/journal.pone.0051070 + http://orcid.org/0000-0002-6601-2165 + @@ -136215,8 +214238,17 @@ + A synovial joint that is part of a pectoral girdle region. + FMA:35243 + SCTID:303080001 synovial joint of pectoral girdle + + + + A synovial joint that is part of a pectoral girdle region. + OBOL:automatic + @@ -136224,8 +214256,16 @@ + Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis. + FMA:7491 nonsynovial joint + + + + Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis. + FMA:7491 + @@ -136239,8 +214279,16 @@ + Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. + FMA:7483 axial skeletal system + + + + Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. + https://orcid.org/0000-0002-6601-2165 + @@ -136254,8 +214302,59 @@ + Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. + FMA:302077 postcranial axial skeletal system + + + + Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. + https://github.com/obophenotype/uberon/issues/44 + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue. + BTO:0003751 + Wikipedia:Submucosal_glands + submucosal gland + + + + + Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue. + BTO:0003751 + Wikipedia:Submucosal_glands + @@ -136270,8 +214369,24 @@ + Subdivision of skull that consists of the facial bones. + EHDAA2:0002206 + EHDAA:8361 + EMAPA:18022 + FMA:53673 + MA:0000318 + Wikipedia:Facial_skeleton facial skeleton + + + + Subdivision of skull that consists of the facial bones. + MP:0005274 + Wikipedia:Facial_skeleton + http://www.bartleby.com/107/37.html + https://orcid.org/0000-0002-6601-2165 + @@ -136285,8 +214400,16 @@ + The skull can be divided into two: the neurocranium and the facial skeleton. + FMA:54964 primary subdivision of skull + + + + The skull can be divided into two: the neurocranium and the facial skeleton. + http://orcid.org/0000-0002-6601-2165 + @@ -136327,8 +214450,203 @@ + A bone that is part of a neurocranium [Automatically generated definition]. + EMAPA:35238 + MA:0001478 + SCTID:120229002 neurocranium bone + + + + A bone that is part of a neurocranium [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Synovial joint that articulates bones of upper and lower jaw. + joint connecting upper and lower jaws + + + + + Synovial joint that articulates bones of upper and lower jaw. + http://evolution.berkeley.edu/evolibrary/article/evograms_05 + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + A sphincter muscle that is part of the gastrointestinal system. + NCIT:C32669 + gastrointestinal sphincter + + + + + A sphincter muscle that is part of the gastrointestinal system. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A lamina propria that is part of a large intestine. + FMA:15654 + NCIT:C49298 + lamina propria of large intestine + + + + + A lamina propria that is part of a large intestine. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of a large intestine. + FMA:14971 + NCIT:C32927 + muscle layer of large intestine + + + + + A muscle layer that is part of a large intestine. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of a small intestine. + FMA:14932 + NCIT:C33569 + SCTID:362145004 + muscle layer of small intestine + + + + + A muscle layer that is part of a small intestine. + OBOL:automatic + @@ -136354,8 +214672,16 @@ + A multi cell part structure that is part of a central nervous system. + FMA:83143 central nervous system cell part cluster + + + + A multi cell part structure that is part of a central nervous system. + OBOL:automatic + @@ -136369,12 +214695,17 @@ - - - - + A subdivision of an anatomical system. + FMA:67509 + SCTID:91690000 organ system subdivision + + + + A subdivision of an anatomical system. + http://orcid.org/0000-0002-6601-2165 + @@ -136389,6 +214720,9 @@ + AAO:0010038 + EMAPA:18808 + FMA:49150 intra-ocular muscle @@ -136415,8 +214749,20 @@ + Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa. + BTO:0001823 + FMA:40878 + Wikipedia:Synovial_sheath + Alternate def: A synovial sheath is a layer of a tendon sheath containing tendons in the hand and foot. They lie internal to the fibrous tendon sheaths. An example is the common synovial sheath for the flexor tendons. [Wikipedia:Synovial_sheath] synovial membrane of synovial tendon sheath + + + + Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa. + FMA:45087 + Wikipedia:Synovial_sheath + @@ -136451,11 +214797,42 @@ + FMA:40877 fibrous membrane of synovial tendon sheath + + + + + + + + + + + + + + + + + The most anterior region of the braincase. Provides structural support for peripheral olfactory organ. + AAO:0000986 + ethmoid region + + + + + The most anterior region of the braincase. Provides structural support for peripheral olfactory organ. + UBERONREF:0000007 + http://palaeos.com/vertebrates/bones/braincase/ethmoid.html + + + + @@ -136472,8 +214849,17 @@ + Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints. + FMA:7484 + VSAO:0000306 appendicular skeletal system + + + + Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints. + https://orcid.org/0000-0002-6601-2165 + @@ -136487,8 +214873,20 @@ + The part of the trunk that is in the dorsum[cjm]. + EMAPA:35162 + FMA:25056 + MA:0000020 + Wikipedia:Human_back dorsal trunk + + + + The part of the trunk that is in the dorsum[cjm]. + UBERONREF:0000006 + Wikipedia:Human_back + @@ -136509,6 +214907,7 @@ + EHDAA2:0001845 embryonic skin basal layer @@ -136530,8 +214929,17 @@ + A blood vasculature that is part of a head. + TAO:0005297 + ZFA:0005297 cranial blood vasculature + + + + A blood vasculature that is part of a head. + OBOL:automatic + @@ -136545,6 +214953,8 @@ + FMA:54364 + SCTID:432899004 lumen of gastrointestinal system @@ -136583,8 +214993,18 @@ + An anatomical cavity that is part of a esophagus. + EMAPA:18380 + FMA:9398 + SCTID:322648002 lumen of esophagus + + + + An anatomical cavity that is part of a esophagus. + OBOL:automatic + @@ -136628,8 +215048,16 @@ + The collection of all skeletal elements in an individual limb or fin. + VSAO:0000301 paired limb/fin skeleton + + + + The collection of all skeletal elements in an individual limb or fin. + https://orcid.org/0000-0002-6601-2165 + @@ -136637,8 +215065,43 @@ + Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). + VSAO:0000006 + XAO:0004021 cell condensation + + + + Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000006 + http://dx.plos.org/10.1371/journal.pone.0051070 + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0002120 + future upper lip + @@ -136676,8 +215139,17 @@ + A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions. + EMAPA:32905 + NCIT:C114916 jaw region + + + + A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions. + http://orcid.org/0000-0002-6601-2165 + @@ -136692,11 +215164,45 @@ + EHDAA2:0001020 future lower lip + + + + + + + + + + + + + + + + + + + + + + Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species). + bone of upper jaw + + + + + Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species). + https://orcid.org/0000-0002-6601-2165 + + + + @@ -136730,8 +215236,16 @@ + An epithelium that develops_from a ectoderm and is part of a oral epithelium. + EHDAA2:0004137 oral epithelium from ectoderm + + + + An epithelium that develops_from a ectoderm and is part of a oral epithelium. + OBOL:automatic + @@ -136745,6 +215259,11 @@ + AAO:0000247 + EFO:0003511 + TAO:0000236 + XAO:0003269 + ZFA:0000236 jaw muscle @@ -136760,8 +215279,50 @@ + A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. subdivision of organism along main body axis + + + + A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly. + trunk vertebra + + + + + A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly. + UBERONREF:0000006 + @@ -136786,8 +215347,18 @@ + A cardiovascular system that is part of a conceptus. + EHDAA2:0000216 + FMA:305965 + NCIT:C34148 embryonic cardiovascular system + + + + A cardiovascular system that is part of a conceptus. + OBOL:automatic + @@ -136818,8 +215389,56 @@ + An anatomical space that is part of a bone of lower jaw. + AAO:0000273 lower jaw opening + + + + An anatomical space that is part of a bone of lower jaw. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that is part of a bone of upper jaw. + AAO:0000621 + upper jaw opening + + + + + An anatomical space that is part of a bone of upper jaw. + OBOL:automatic + @@ -136844,8 +215463,16 @@ + A neural nucleus that is part of the spinal cord. + FMA:77011 nucleus of spinal cord + + + + A neural nucleus that is part of the spinal cord. + http://orcid.org/0000-0002-6601-2165 + @@ -136870,8 +215497,15 @@ + A nerve that is part of a head. nerve of head region + + + + A nerve that is part of a head. + OBOL:automatic + @@ -136879,8 +215513,16 @@ + Ectodermal placode that does not develop into a component of the nervous system. non-neurogenic ectodermal placode + + + + Ectodermal placode that does not develop into a component of the nervous system. + PMID:11523831 + http://orcid.org/0000-0002-6601-2165 + @@ -136926,9 +215568,17 @@ - + An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart. + EHDAA2:0004149 + FMA:85125 atrioventricular region + + + + An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -136936,8 +215586,16 @@ + Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium. + FMA:20107 irregular connective tissue + + + + Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium. + FMA:20107 + @@ -136967,8 +215625,19 @@ + Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. + FMA:20109 + NCIT:C32882 + Wikipedia:Dense_irregular_connective_tissue dense irregular connective tissue + + + + Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. + FMA:20109 + Wikipedia:Dense_irregular_connective_tissue + @@ -136994,8 +215663,18 @@ + Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets. + AAO:0000121 + NCIT:C32450 + Wikipedia:Dense_connective_tissue dense connective tissue + + + + Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets. + Wikipedia:Dense_connective_tissue + @@ -137003,6 +215682,8 @@ + FMA:75634 + SCTID:363130003 fibrous connective tissue @@ -137012,8 +215693,18 @@ + Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. + FMA:19783 + NCIT:C33007 + Wikipedia:Loose_connective_tissue loose connective tissue + + + + Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. + FMA:19783 + @@ -137038,8 +215729,15 @@ + An acinus that is part of a exocrine gland. acinus of exocrine gland + + + + An acinus that is part of a exocrine gland. + OBOL:automatic + @@ -137059,6 +215757,10 @@ + FMA:63212 + MESH:D024022 + NCIT:C32339 + NIF_Subcellular:sao7547390221 collection of collagen fibrils @@ -137092,8 +215794,15 @@ + The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity. aorta collagen fibril + + + + The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity. + MP:0011640 + @@ -137125,8 +215834,15 @@ + The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity. pulmonary collagen fibril + + + + The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity. + MP:0011641 + @@ -137151,8 +215867,15 @@ + The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity. bone collagen fibril + + + + The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity. + MP:0011642 + @@ -137183,8 +215906,15 @@ + The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity. tendon collagen fibril + + + + The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity. + MP:0011643 + @@ -137216,8 +215946,55 @@ + The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity. corneal stroma collagen fibril + + + + The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity. + MP:0011650 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of a wall of esophagus. + FMA:62998 + muscle layer of esophagus + + + + + A muscle layer that is part of a wall of esophagus. + OBOL:automatic + @@ -137256,8 +216033,16 @@ + Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris. + SCTID:280656002 anterior uvea + + + + Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris. + MP:0005194 + @@ -137284,8 +216069,18 @@ + Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous. + FMA:9726 + NCIT:C32527 + Wikipedia:Epimysium epimysium + + + + Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous. + Wikipedia:Epimysium + @@ -137317,8 +216112,17 @@ + Masses of developing blood cells attached to endothelium in the yolk sac. + EHDAA2:0000177 + EMAPA:16115 yolk sac blood island + + + + Masses of developing blood cells attached to endothelium in the yolk sac. + MP:0011204 + @@ -137343,8 +216147,91 @@ + A region of the stomach that is lined with glandular epithelium. + EMAPA:17623 + MA:0001613 + NCIT:C77661 + SCTID:27633001 stomach glandular region + + + + A region of the stomach that is lined with glandular epithelium. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic vein that is part of a left lobe of liver. + FMA:14339 + MA:0003032 + SCTID:55188000 + left hepatic vein + + + + + A hepatic vein that is part of a left lobe of liver. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic vein that is part of a right lobe of liver. + FMA:14338 + MA:0003034 + SCTID:18135006 + right hepatic vein + + + + + A hepatic vein that is part of a right lobe of liver. + OBOL:automatic + @@ -137358,8 +216245,19 @@ + The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. + EHDAA2:0004731 + Wikipedia:Coelom coelom + + + + The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. + UBERON:cjm + Wikipedia:Body_cavity + Wikipedia:Coelom + @@ -137384,8 +216282,73 @@ + The cavity within a myotome. + EMAPA:31134 + VHOG:0001283 myocoele + + + + The cavity within a myotome. + http://medical-dictionary.thefreedictionary.com/myocoele + + + + + + + + + + + + + + + + + + + + + + + + + + + Any bone that is part of a palate. + NCIT:C33248 + palate bone + + + + + Any bone that is part of a palate. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + palatal part of dermatocranium + @@ -137394,8 +216357,18 @@ + Bone that forms as a replacement of another structural tissue. + AAO:0010768 + TAO:0001637 + ZFA:0001628 replacement bone + + + + Bone that forms as a replacement of another structural tissue. + ZFA:0001628 + @@ -137415,8 +216388,17 @@ + An anatomical cavity that is part of a bronchus. + FMA:62646 + SCTID:199401001 bronchial lumen + + + + An anatomical cavity that is part of a bronchus. + OBOL:automatic + @@ -137447,8 +216429,17 @@ + A primordium that has the potential to develop into a stomach. + EFO:0002580 + NCIT:C34305 stomach primordium + + + + A primordium that has the potential to develop into a stomach. + OBOL:automatic + @@ -137473,8 +216464,17 @@ + A zone of skin that is part of a craniocervical region. + MA:0000574 + NCIT:C12294 head or neck skin + + + + A zone of skin that is part of a craniocervical region. + OBOL:automatic + @@ -137499,8 +216499,17 @@ + The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins. + MA:0002194 + NCIT:C53062 phrenic vein + + + + The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins. + ncithesaurus:Phrenic_Vein + @@ -137525,8 +216534,17 @@ + An artery that originates from the abdominal aorta. + SCTID:281470000 abdominal aorta artery + + + + An artery that originates from the abdominal aorta. + Wikipedia:Abdominal_aorta#Branches + https://orcid.org/0000-0002-6601-2165 + @@ -137540,8 +216558,16 @@ + An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]. + Wikipedia:Columnar_epithelium columnar epithelium + + + + An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]. + Wikipedia:Columnar_epithelium + @@ -137561,8 +216587,16 @@ + Epithelium that derives from the mesoderm. [Automatically generated definition]. + FMA:86452 meso-epithelium + + + + Epithelium that derives from the mesoderm. [Automatically generated definition]. + OBOL:automatic + @@ -137582,8 +216616,17 @@ + One of five swellings formed during the development of the face. + FMA:293103 + SCTID:89066004 embryonic facial prominence + + + + One of five swellings formed during the development of the face. + http://www.indiana.edu/~anat550/hnanim/face/face.html + @@ -137603,8 +216646,16 @@ + An artery of the neck. + NCIT:C52850 cervical artery + + + + An artery of the neck. + https://orcid.org/0000-0002-6601-2165 + @@ -137635,9 +216686,18 @@ - + The deep cervical artery (Profunda cervicalis) is an artery of the neck. + FMA:10659 + SCTID:244223002 + Wikipedia:Deep_cervical_artery deep cervical artery + + + + The deep cervical artery (Profunda cervicalis) is an artery of the neck. + Wikipedia:Deep_cervical_artery + @@ -137645,9 +216705,19 @@ - + The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery. + FMA:10664 + MA:0001936 + SCTID:244224008 + Wikipedia:Transverse_cervical_artery transverse cervical artery + + + + The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery. + Wikipedia:Transverse_cervical_artery + @@ -137673,8 +216743,68 @@ + A bone element that is part of a jaw region. + EMAPA:35453 + MA:0003130 + SCTID:369003004 bone of jaw + + + + A bone element that is part of a jaw region. + OBOL:automatic + + + + + + + + + + + + + + + EHDAA2:0004588 + internal anal region + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of an intestine. + FMA:15697 + muscle layer of intestine + + + + + A muscle layer that is part of an intestine. + OBOL:automatic + @@ -137715,9 +216845,20 @@ - + A layer of tissue between the muscularis and serosa. + FMA:45636 + NCIT:C94494 + SCTID:2255006 + Wikipedia:Subserosa + Contains nerves, blood vessels, lymphatics and lymph nodes subserosa + + + + A layer of tissue between the muscularis and serosa. + Wikipedia:Subserosa + @@ -137743,7 +216884,7 @@ - + MA:0001802 respiratory system arterial smooth muscle @@ -137770,9 +216911,68 @@ - + A smooth muscle tissue that is part of a respiratory system venous blood vessel. + MA:0001812 respiratory system venous smooth muscle + + + + A smooth muscle tissue that is part of a respiratory system venous blood vessel. + OBOL:automatic + + + + + + + + + + + + + + + A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]. + FMA:67296 + MESH:D008871 + NCIT:C33112 + Wikipedia:Microvillus + layer of microvilli + + + + + A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]. + GO:0005902 + Wikipedia:Microvillus + + + + + + + + + + + + + + + A microvillus layer that is striated and found in the intestine. + FMA:70978 + NCIT:C33634 + striated border microvillus layer + + + + + A microvillus layer that is striated and found in the intestine. + http://medical-dictionary.thefreedictionary.com/striated+border + http://orcid.org/0000-0002-6601-2165 + @@ -137804,8 +217004,18 @@ + Blood-forming tissue, consisting of reticular fibers and cells. + CALOHA:TS-2142 + FMA:14073 + NCIT:C13051 hematopoietic tissue + + + + Blood-forming tissue, consisting of reticular fibers and cells. + http://encyclopedia2.thefreedictionary.com/hematopoietic+tissue + @@ -137833,8 +217043,137 @@ + The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth. + FMA:58102 + SCTID:361318005 + Wikipedia:Fibrous_tunic_of_eyeball tunica fibrosa of eyeball + + + + The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth. + Wikipedia:Fibrous_tunic_of_eyeball + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that is enclosed by a cloaca. + TAO:0000330 + ZFA:0000330 + cloacal lumen + + + + + An anatomical space that is enclosed by a cloaca. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives. + cloacal vent + + + + + The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that is enclosed by a terminal part of digestive tract. + lumen of terminal part of digestive tract + + + + + An anatomical space that is enclosed by a terminal part of digestive tract. + OBOL:automatic + @@ -137859,6 +217198,9 @@ + EHDAA2:0000472 + EMAPA:16054 + VHOG:0000767 extraembryonic cavity @@ -137885,8 +217227,32 @@ + An anatomical space with no opening to another space or to the exterior. + AEO:0000222 enclosed anatomical space + + + + An anatomical space with no opening to another space or to the exterior. + AEO:0000222 + + + + + + + + + + + + + + + EHDAA2:0004589 + external anal region + @@ -137923,8 +217289,384 @@ + The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle. + FMA:24139 skeleton of pectoral complex + + + + The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + The posterior region of the neck, including the suboccipital region. + BTO:0000957 + FMA:24189 + SCTID:182326009 + SCTID:304036007 + dorsal part of neck + + + + + The posterior region of the neck, including the suboccipital region. + MP:0012723 + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a cloaca. + cloacal gland + + + + + A gland that is part of a cloaca. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a cloaca [Automatically generated definition]. + cloacal mucosa + + + + + A mucosa that is part of a cloaca [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a cloaca. + EMAPA:27577 + EMAPA:36070 + ZFA:0005783 + cloacal epithelium + + + + + An epithelium that is part of a cloaca. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a cloaca [Automatically generated definition]. + submucosa of cloaca + + + + + A submucosa that is part of a cloaca [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a cloaca [Automatically generated definition]. + serosa of cloaca + + + + + A serous membrane that is part of a cloaca [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + cloacal villus + + + + + + + + + + + + + + + + + + + + + + + + + + A muscular coat that is part of a cloaca. + muscle layer of cloaca + + + + + A muscular coat that is part of a cloaca. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscular coat that is part of a duodenum. + FMA:14944 + SCTID:362147007 + muscle layer of duodenum + + + + + A muscular coat that is part of a duodenum. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscular coat that is part of a colon. + EMAPA:27383 + FMA:14986 + MA:0003198 + SCTID:362158003 + muscle layer of colon + + + + + A muscular coat that is part of a colon. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A muscular coat that is part of a anal canal. + FMA:15708 + SCTID:362171000 + muscle layer of anal canal + + + + + A muscular coat that is part of a anal canal. + OBOL:automatic + @@ -137949,8 +217691,108 @@ + An adventitia that is part of a esophagus. + FMA:63006 + SCTID:85950006 adventitia of esophagus + + + + An adventitia that is part of a esophagus. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical junction that connects a stomach and connects a duodenum. + FMA:17046 + SCTID:264014000 + gastroduodenal junction + + + + + An anatomical junction that connects a stomach and connects a duodenum. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a gastroduodenal junction. + BTO:0005415 + mucosa of gastroduodenal junction + + + + + A mucosa that is part of a gastroduodenal junction. + OBOL:automatic + @@ -137970,8 +217812,16 @@ + A vein that is part of a abdomen. + SCTID:281473003 vein of abdomen + + + + A vein that is part of a abdomen. + OBOL:automatic + @@ -137991,8 +217841,17 @@ + The part of the venous system that drains the lungs[Kardong]. + Wikipedia:Pulmonary_venous_system pulmonary venous system + + + + The part of the venous system that drains the lungs[Kardong]. + ISBN:0073040584 + Wikipedia:Pulmonary_venous_system + @@ -138023,8 +217882,16 @@ + A vein that drains a lip. + SCTID:367664002 vein of lip + + + + A vein that drains a lip. + OBOL:automatic + @@ -138049,8 +217916,86 @@ + Any vein within the general circulation that transports blood back to the right atrium of the heart. + FMA:66644 + NCIT:C33719 + SCTID:244389004 systemic vein + + + + Any vein within the general circulation that transports blood back to the right atrium of the heart. + ncithesaurus:Systemic_Vein + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a foregut-midgut junction. + EHDAA2:0000574 + EMAPA:17065 + foregut-midgut junction gland + + + + + A gland that is part of a foregut-midgut junction. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A bodily secretion that is produced by a gland of anal sac. + anal sac gland secretion + + + + + A bodily secretion that is produced by a gland of anal sac. + OBOL:automatic + @@ -138081,8 +218026,17 @@ + The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. + FMA:86279 serous acinus + + + + The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. + http://orcid.org/0000-0002-6601-2165 + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -138113,8 +218067,21 @@ + Anatomical cavity that is the lumen of the skull and contains the brain. + FMA:9644 + MA:0003061 + NCIT:C77638 + SCTID:264452006 + Wikipedia:Cranial_cavity + neuronames:2806 cranial cavity + + + + Anatomical cavity that is the lumen of the skull and contains the brain. + UBERON:cjm + @@ -138135,8 +218102,260 @@ + A blood vessel endothelium that is part of a lung [Automatically generated definition]. + BTO:0004128 + CALOHA:TS-0573 lung endothelium + + + + A blood vessel endothelium that is part of a lung [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A sphincter muscle that is part of a cloaca. + NCIT:C34129 + the muscles of the cloacal sphincter specialise into the perineal muscles in mammals (Gegenbaur, 1883; Popowsky, 1899; Nishi, 1938). + cloacal sphincter + + + + + A sphincter muscle that is part of a cloaca. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A caudal vertebra endochondral element that is composed primarily of cartilage tissue. + EHDAA2:0000260 + EMAPA:18044 + caudal vertebra cartilage element + + + + + A caudal vertebra endochondral element that is composed primarily of cartilage tissue. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + EMAPA:18045 + caudal vertebra pre-cartilage condensation + + + + + A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A cervical vertebra endochondral element that is composed primarily of cartilage tissue. + EHDAA2:0000240 + cervical vertebra cartilage element + + + + + A cervical vertebra endochondral element that is composed primarily of cartilage tissue. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + cervical vertebra pre-cartilage condensation + + + + + A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A thoracic vertebra endochondral element that is composed primarily of cartilage tissue. + EHDAA2:0002014 + thoracic vertebra cartilage element + + + + + A thoracic vertebra endochondral element that is composed primarily of cartilage tissue. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + thoracic vertebra pre-cartilage condensation + + + + + A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + OBOL:automatic + @@ -138161,8 +218380,15 @@ + The space that surrounds an organism. space surrounding organism + + + + The space that surrounds an organism. + https://orcid.org/0000-0002-6601-2165 + @@ -138226,8 +218452,57 @@ + The anatomical space that is enclosed by a stomach. + EMAPA:18395 + FMA:14585 stomach lumen + + + + The anatomical space that is enclosed by a stomach. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a intestinal villus. + FMA:63587 + epithelium of intestinal villus + + + + + An epithelium that is part of a intestinal villus. + OBOL:automatic + @@ -138252,8 +218527,19 @@ + Anatomical space that is an opening in a bone of the skull. + FMA:53165 + SCTID:276742007 + Wikipedia:Foramina_of_the_skull foramen of skull + + + + Anatomical space that is an opening in a bone of the skull. + TAO:curator + http://orcid.org/0000-0002-6601-2165 + @@ -138274,11 +218560,17 @@ - - - + An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. + FMA:9338 anatomical conduit space + + + + An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. + FMA:9338 + http://orcid.org/0000-0002-6601-2165 + @@ -138304,8 +218596,81 @@ + Vascular endothelium found in blood vessels of the blood-brain-barrier. + BTO:0001852 + BTO:0003248 + CALOHA:TS-0092 brain endothelium + + + + Vascular endothelium found in blood vessels of the blood-brain-barrier. + CALOHA:TS-0092 + + + + + + + + + + + + + + + + + + + + + Vascular endothelium found in colon blood vessels. + CALOHA:TS-0162 + colon endothelium + + + + + Vascular endothelium found in colon blood vessels. + CALOHA:TS-0162 + + + + + + + + + + + + + + + + + + + + + + + + + + Epithelium lining the exocrine pancreas. + CALOHA:TS-2108 + exocrine pancreas epithelium + + + + + Epithelium lining the exocrine pancreas. + CALOHA:TS-2108 + @@ -138340,8 +218705,17 @@ + Musculature of the head and neck, spine, and ribs. + EHDAA2:0000159 + EMAPA:18166 axial musculature + + + + Musculature of the head and neck, spine, and ribs. + HP:0003327 + @@ -138355,8 +218729,15 @@ + A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. main body axis + + + + A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. + https://orcid.org/0000-0002-6601-2165 + @@ -138370,8 +218751,18 @@ + The region of the organism associated with the visceral organs. + AEO:0000103 + BTO:0001489 + FMA:231424 body proper + + + + The region of the organism associated with the visceral organs. + AEO:0000103 + @@ -138397,8 +218788,17 @@ + A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily. + FMA:293127 + NCIT:C34230 notochordal canal + + + + A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily. + http://medical-dictionary.thefreedictionary.com/notochordal+canal + @@ -138433,8 +218833,17 @@ + Fluid contained within the notochordal canal. + Distinct feature of coelocanths notochordal fluid + + + + Fluid contained within the notochordal canal. + http://animaldiversity.org/accounts/Latimeria_chalumnae/ + http://orcid.org/0000-0002-6601-2165 + @@ -138459,8 +218868,16 @@ + An organ component layer that is part of a integumental system. + SCTID:314820002 integumentary system layer + + + + An organ component layer that is part of a integumental system. + OBOL:automatic + @@ -138485,8 +218902,16 @@ + A blood that is part of a artery. + FMA:83066 arterial blood + + + + A blood that is part of a artery. + OBOL:automatic + @@ -138511,8 +218936,16 @@ + A blood that is part of a vein. + FMA:83067 venous blood + + + + A blood that is part of a vein. + OBOL:automatic + @@ -138537,8 +218970,17 @@ + A blood that is part of a capillary. + FMA:263901 + NCIT:C32212 capillary blood + + + + A blood that is part of a capillary. + OBOL:automatic + @@ -138563,8 +219005,16 @@ + Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements. + SCTID:272627002 digestive system element + + + + Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements. + http://orcid.org/0000-0002-6601-2165 + @@ -138572,8 +219022,19 @@ + Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart. + EMAPA:36460 + SCTID:304066000 + Wikipedia:Great_vessels + Groupings may vary - typically pulmonary vessels and aorta and vena cavae great vessel of heart + + + + Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart. + Wikipedia:Great_vessels + @@ -138593,8 +219054,18 @@ + Mesenchyme that develops_from the neural crest[Automatically generated definition]. + EMAPA:32735 + FMA:293883 mesenchyme derived from neural crest + + + + Mesenchyme that develops_from the neural crest[Automatically generated definition]. + OBOL:automatic + https://github.com/obophenotype/uberon/issues/248 + @@ -138625,8 +219096,15 @@ + Muscle that is part of the respiratory system. respiratory muscle + + + + Muscle that is part of the respiratory system. + http://orcid.org/0000-0002-6601-2165 + @@ -138657,8 +219135,50 @@ + An anatomical space that is enclosed by a sinusoid. + FMA:63133 sinusoidal space + + + + An anatomical space that is enclosed by a sinusoid. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A sinusoidal space that is part of a hepatic sinusoid. + FMA:262090 + hepatic sinusoidal space + + + + + A sinusoidal space that is part of a hepatic sinusoid. + OBOL:automatic + @@ -138683,8 +219203,18 @@ + A part of the body present only in a specific gender. + AEO:0000174 + WBbt:0005752 sex-specific anatomical structure + + + + A part of the body present only in a specific gender. + AEO:0000174 + AEO:JB + @@ -138709,8 +219239,17 @@ + A part of the body present only in females. + AEO:0000176 female anatomical structure + + + + A part of the body present only in females. + AEO:0000176 + AEO:JB + @@ -138749,8 +219288,20 @@ + Subcutaneous adipose tissue that is located in the peritoneal cavity. + BTO:0004041 + CALOHA:TS-2405 visceral abdominal adipose tissue + + + + Subcutaneous adipose tissue that is located in the peritoneal cavity. + CALOHA:paula + MGI:csmith + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/259 + @@ -138774,8 +219325,19 @@ + Subcutaneous adipose tissue that is located in the abdominal region. + CALOHA:TS-2406 subcutaneous abdominal adipose tissue + + + + Subcutaneous adipose tissue that is located in the abdominal region. + CALOHA:paula + MGI:csmith + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/259 + @@ -138795,9 +219357,19 @@ - + Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. + EHDAA2:0002013 + FMA:77169 + Wikipedia:Thoracic_skeleton thoracic skeleton + + + + Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. + Wikipedia:Rib_cage + https://orcid.org/0000-0002-6601-2165 + @@ -138822,9 +219394,17 @@ - + A ventral horn of spinal cord that is part of a thoracic spinal cord. + BIRNLEX:1410 + SCTID:367876000 thoracic spinal cord ventral horn + + + + A ventral horn of spinal cord that is part of a thoracic spinal cord. + OBOL:automatic + @@ -138849,9 +219429,17 @@ - + A gray matter of spinal cord that is part of a cervical spinal cord. + BIRNLEX:1521 + SCTID:362438009 cervical spinal cord gray matter + + + + A gray matter of spinal cord that is part of a cervical spinal cord. + OBOL:automatic + @@ -138876,9 +219464,17 @@ - + A ventral horn of spinal cord that is part of a cervical spinal cord. + BIRNLEX:1680 + SCTID:174363005 cervical spinal cord ventral horn + + + + A ventral horn of spinal cord that is part of a cervical spinal cord. + OBOL:automatic + @@ -138903,9 +219499,100 @@ - + A gray matter of spinal cord that is part of a thoracic spinal cord. + BIRNLEX:980 + SCTID:362441000 thoracic spinal cord gray matter + + + + A gray matter of spinal cord that is part of a thoracic spinal cord. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a frontonasal prominence. + EHDAA2:0004108 + EMAPA:32918 + frontonasal process epithelium + + + + + An epithelium that is part of a frontonasal prominence. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A unilaminar epithelium that develops_from a ectoderm and is part of a anal region. + EHDAA2:0004019 + EMAPA:25040 + anal membrane ectodermal component + + + + + A unilaminar epithelium that develops_from a ectoderm and is part of a anal region. + OBOL:automatic + @@ -138936,8 +219623,17 @@ + An anatomical space that is enclosed by a pleuroperitoneal canal. + EHDAA2:0004736 + EMAPA:25034 pleuroperitoneal canal lumen + + + + An anatomical space that is enclosed by a pleuroperitoneal canal. + OBOL:automatic + @@ -138972,9 +219668,59 @@ - + A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory. + NCIT:C32828 + UMLS:C1512857 + Wikipedia:Interlobular_ducts interlobular duct + + + + A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory. + ncithesaurus:Interlobular_Duct + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells. + FMA:86278 + mucous acinus + + + + + The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells. + http://orcid.org/0000-0002-6601-2165 + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -138999,9 +219745,16 @@ - + A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular. + SCTID:205214009 intralobular duct + + + + A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular. + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -139036,8 +219789,15 @@ + A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory. interlobar duct + + + + A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory. + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -139062,8 +219822,17 @@ + A neuromere that is part of the presumptive midbrain. + EHDAA2:0004352 + FMA:61997 midbrain neuromere + + + + A neuromere that is part of the presumptive midbrain. + http://orcid.org/0000-0002-6601-2165 + @@ -139088,8 +219857,51 @@ + A neuromere that is part of the presumptive spinal cord. + TAO:0001332 + ZFA:0001332 spinal neuromere + + + + A neuromere that is part of the presumptive spinal cord. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any muscle organ that is part of a cloaca. + cloacal muscle + + + + + Any muscle organ that is part of a cloaca. + OBOL:automatic + @@ -139114,8 +219926,16 @@ + Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin. + FMA:71296 musculature of pectoral complex + + + + Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin. + OBOL:automatic + @@ -139140,8 +219960,15 @@ + Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin). pectoral appendage muscle + + + + Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin). + OBOL:automatic + @@ -139208,9 +220035,34 @@ - + A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles). + AAO:0011099 + BTO:0001103 + CALOHA:TS-0933 + EFO:0000888 + EHDAA:5035 + EHDAA:5043 + EHDAA:5978 + EHDAA:5984 + EMAPA:35988 + EV:0100377 + GAID:141 + MA:0003148 + MAT:0000302 + MESH:D018482 + MIAA:0000302 + TAO:0005277 + VHOG:0000319 + XAO:0000174 + ZFA:0005277 skeletal muscle organ, vertebrate + + + + A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles). + GOC:dos + @@ -139241,8 +220093,19 @@ + A portion of tissue that will develop into vasculature. + EFO:0003708 + TAO:0005076 + ZFA:0005076 primordial vasculature + + + + A portion of tissue that will develop into vasculature. + ZFA:0005076 + ZFA:curator + @@ -139256,8 +220119,138 @@ + One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites. + EFO:0003664 + TAO:0001285 + XAO:0004075 + ZFA:0001285 intersomitic vessel + + + + One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites. + MGI:anna + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vertebral endochondral element in the cervical region of the vertebral column. + cervical vertebra endochondral element + + + + + A vertebral endochondral element in the cervical region of the vertebral column. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vertebral endochondral element in the thoracic region of the vertebral column. + thoracic vertebra endochondral element + + + + + A vertebral endochondral element in the thoracic region of the vertebral column. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + A sphenoid bone or its cartilage or pre-cartilage precursor. + sphenoid endochondral element + + + + + A sphenoid bone or its cartilage or pre-cartilage precursor. + https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern + @@ -139271,6 +220264,7 @@ + FMA:83105 subepicardial layer of epicardium @@ -139325,8 +220319,16 @@ + Visceral intrapericardial fat contiguous with the myocardial surface. + FMA:9871 epicardial fat + + + + Visceral intrapericardial fat contiguous with the myocardial surface. + DOI:10.5935/abc.20130138 + @@ -139351,8 +220353,16 @@ + A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands. gland of ocular region + + + + A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands. + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/614 + @@ -139377,8 +220387,16 @@ + An eye consisting of multiple light-sensing organs. multi-unit eye + + + + An eye consisting of multiple light-sensing organs. + PMID:21062451 + http://orcid.org/0000-0002-6601-2165 + @@ -139413,8 +220431,18 @@ + A region of somite adjacent to presomitic mesoderm. + TAO:0001462 + XAO:0004074 + ZFA:0001462 somite border + + + + A region of somite adjacent to presomitic mesoderm. + http://orcid.org/0000-0002-6601-2165 + @@ -139439,8 +220467,17 @@ + Epithelium located in the intersomitic region. + XAO:0004077 somite boundary epithelium + + + + Epithelium located in the intersomitic region. + XAO:0004077 + XAO:EJS + @@ -139448,8 +220485,19 @@ + An anatomical group whose component structures share a common function. + AEO:0000093 non-connected functional system + + + + An anatomical group whose component structures share a common function. + AEO:0000093 + AEO:JB + FBC:DOS + FBbt:00007278 + @@ -139474,8 +220522,16 @@ + A non-connected functional system that is composed primarily of a gland. + EHDAA2:0002223 glandular system + + + + A non-connected functional system that is composed primarily of a gland. + OBOL:automatic + @@ -139506,8 +220562,15 @@ + Any structure that is placed on one side of the left-right axis of a bilaterian. lateral structure + + + + Any structure that is placed on one side of the left-right axis of a bilaterian. + http://orcid.org/0000-0002-6601-2165 + @@ -139527,8 +220590,85 @@ + A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. circulatory organ + + + + A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + A pancreatic lobule that is in_the_left_side_of a exocrine pancreas. + MA:0000722 + pancreas left lobe + + + + + A pancreatic lobule that is in_the_left_side_of a exocrine pancreas. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A pancreatic lobule that is in_the_right_side_of a exocrine pancreas. + MA:0000723 + pancreas right lobe + + + + + A pancreatic lobule that is in_the_right_side_of a exocrine pancreas. + OBOL:automatic + @@ -139553,8 +220693,16 @@ + A basement membrane of epithelium that is part of a respiratory system. + MA:0001815 respiratory system basement membrane + + + + A basement membrane of epithelium that is part of a respiratory system. + OBOL:automatic + @@ -139568,16 +220716,207 @@ - + MA:0002449 heart plus pericardium + + + + + + + + + + + The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery. + FMA:14772 + MA:0003095 + SCTID:244262006 + Wikipedia:Hepatic_artery_proper + proper hepatic artery + + + + + The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery. + Wikipedia:Hepatic_artery_proper + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic artery that is part of a left lobe of liver. + FMA:14779 + MA:0003096 + left hepatic artery + + + + + A hepatic artery that is part of a left lobe of liver. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic artery that is part of a right lobe of liver. + FMA:14778 + MA:0003097 + right hepatic artery + + + + + A hepatic artery that is part of a right lobe of liver. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla. + MA:0003108 + choledocho-duodenal junction + + + + + Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla. + http://medical-dictionary.thefreedictionary.com/choledochoduodenal+junction + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a anal canal. + EMAPA:18835 + FMA:17511 + anal canal epithelium + + + + + An epithelium that is part of a anal canal. + OBOL:automatic + + + + + FMA:62798 heterogeneous tissue @@ -139604,8 +220943,52 @@ + A smooth muscle tissue that is part of a hypodermis. + FMA:77862 smooth muscle layer in fatty layer of subcutaneous tissue + + + + A smooth muscle tissue that is part of a hypodermis. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a liver. + EMAPA:35498 + MA:0003137 + liver blood vessel + + + + + A blood vessel that is part of a liver. + OBOL:automatic + @@ -139631,8 +221014,17 @@ + An epithelium that is part of a camera-type eye. + EMAPA:35957 + MA:0003162 eye epithelium + + + + An epithelium that is part of a camera-type eye. + OBOL:automatic + @@ -139657,8 +221049,53 @@ + An epithelium that is part of a foregut. + EMAPA:32922 + MA:0003204 foregut epithelium + + + + An epithelium that is part of a foregut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A lamina propria that is part of a duodenum. + EMAPA:27255 + FMA:15972 + MA:0003209 + duodenum lamina propria + + + + + A lamina propria that is part of a duodenum. + OBOL:automatic + @@ -139678,9 +221115,16 @@ - + A capillary that is part of a lung. + FMA:14121 pulmonary capillary + + + + A capillary that is part of a lung. + OBOL:automatic + @@ -139715,8 +221159,51 @@ + A hole in the diaphragm through which the esophagus passes. + FMA:58289 esophageal hiatus + + + + A hole in the diaphragm through which the esophagus passes. + HP:0002036 + + + + + + + + + + + + + + + + + + + + + + + + + + + A stroma that is part of a liver. + FMA:17553 + liver stroma + + + + + A stroma that is part of a liver. + OBOL:automatic + @@ -139747,8 +221234,22 @@ + Is the sensory system for the sense of hearing. + EMAPA:36002 + FMA:7192 + MA:0002443 + NCIT:C12889 + NLXANAT:090817 + Wikipedia:Auditory_system + neuronames:2888 auditory system + + + + Is the sensory system for the sense of hearing. + NLXANAT:090817 + @@ -139773,8 +221274,52 @@ + Luminal space of the right ventricle of the heart. + EMAPA:26047 + FMA:9291 cavity of right ventricle + + + + Luminal space of the right ventricle of the heart. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that is part of a duodenum. + EMAPA:19080 + FMA:14589 + lumen of duodenum + + + + + An anatomical space that is part of a duodenum. + OBOL:automatic + @@ -139799,8 +221344,17 @@ + Luminal space of the left atrium of the heart. + EMAPA:26011 + FMA:9465 cavity of left atrium + + + + Luminal space of the left atrium of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -139825,8 +221379,17 @@ + Luminal space of the left ventricle of the heart. + EMAPA:26038 + FMA:9466 cavity of left ventricle + + + + Luminal space of the left ventricle of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -139851,8 +221414,17 @@ + Luminal space of the right atrium of the heart. + EMAPA:26020 + FMA:11359 cavity of right atrium + + + + Luminal space of the right atrium of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -139883,8 +221455,18 @@ + The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches. + TAO:0001379 + ZFA:0001379 pharyngeal ectoderm + + + + The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches. + PMID:23020903 + http://orcid.org/0000-0002-6601-2165 + @@ -139909,8 +221491,16 @@ + A layer of of the central nervous system that is part of gray matter. + FMA:83142 central nervous system gray matter layer + + + + A layer of of the central nervous system that is part of gray matter. + http://orcid.org/0000-0002-6601-2165 + @@ -139929,6 +221519,93 @@ + + + + + + + + + + + + + + + + + + + + + + Mucus produced in the respiratory tract. + NCIT:C93171 + UMLS:C0225378 + phlegm + + + + + Mucus produced in the respiratory tract. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm). + respiratory system mucus + + + + + Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm). + Wikipedia:Nasal_mucus#Respiratory_system + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + An roughly circular indentation in a surface. + AEO:0000204 + pit + + + + + An roughly circular indentation in a surface. + AEO:0000204 + AEO:JB + + + + @@ -139951,11 +221628,54 @@ + FMA:68861 + Wikipedia:Rexed_laminae + http://neurolex.org/wiki/Category:Rexed_spinal_cord_parcellation_scheme_region lamina of gray matter of spinal cord + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The dorsal region of the optic cup that gives rise to the dorsal part of the retina. + dorsal part of optic cup + + + + + The dorsal region of the optic cup that gives rise to the dorsal part of the retina. + http://orcid.org/0000-0002-6601-2165 + + + + @@ -139989,8 +221709,15 @@ + Primordium that develops into the central nervous system. future central nervous system + + + + Primordium that develops into the central nervous system. + http://orcid.org/0000-0002-6601-2165 + @@ -140021,8 +221748,84 @@ + Primordium that develops into the nervous system. + AAO:0000477 future nervous system + + + + Primordium that develops into the nervous system. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Epithelium lining the distalmost portion of the digestive tract. + BTO:0005445 + WBbt:0005800 + epithelium of terminal part of digestive tract + + + + + Epithelium lining the distalmost portion of the digestive tract. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Any muscle tissue of the distalmost portion of the digestive tract. + muscle tissue of terminal part of digestive tract + + + + + Any muscle tissue of the distalmost portion of the digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -140048,8 +221851,19 @@ + The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism. + AEO:0000195 + EHDAA2:0000003 + EMAPA:16042 entire extraembryonic component + + + + The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism. + AEO:0000195 + AEO:JB + @@ -140057,8 +221871,17 @@ + An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development. + AEO:0000132 transitional anatomical structure + + + + An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development. + AEO:0000132 + AEO:JB + @@ -140083,8 +221906,17 @@ + A mesenchyme-derived anatomical entity undergoing a transtion to become another structure. + AEO:0001016 developing mesenchymal structure + + + + A mesenchyme-derived anatomical entity undergoing a transtion to become another structure. + AEO:0001016 + AEO:JB + @@ -140104,8 +221936,86 @@ + A viscus that is part of a abdomen. + FMA:32413 + FMA:67355 abdominal viscera + + + + A viscus that is part of a abdomen. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of the rectum. + FMA:15035 + muscle layer of rectum + + + + + A muscle layer that is part of the rectum. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any portion of smooth muscle tissue that is part of the rectum. + rectum smooth muscle tissue + + + + + Any portion of smooth muscle tissue that is part of the rectum. + http://orcid.org/0000-0002-6601-2165 + @@ -140130,11 +222040,55 @@ + FMA:83521 fibrocollagenous connective tissue + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx). + caudal vertebra endochondral element + + + + + Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx). + http://orcid.org/0000-0002-6601-2165 + + + + @@ -140156,8 +222110,87 @@ + A zone of skin that is part of a lower lip. + FMA:24767 + SCTID:281630002 skin of lower lip + + + + A zone of skin that is part of a lower lip. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a upper lip. + FMA:24765 + SCTID:281629007 + skin of upper lip + + + + + A zone of skin that is part of a upper lip. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A stroma that is part of a pancreas. + FMA:63121 + stroma of pancreas + + + + + A stroma that is part of a pancreas. + OBOL:automatic + @@ -140189,8 +222222,15 @@ + A boundary delimiting a rhombomere. rhombomere boundary + + + + A boundary delimiting a rhombomere. + GO:0021654 + @@ -140210,7 +222250,8 @@ - + EHDAA2:0001842 + EMAPA:35578 skeletal musculature @@ -140237,8 +222278,15 @@ + Any portion of submucosa that lines the digestive tract. submucosa of digestive tract + + + + Any portion of submucosa that lines the digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -140263,8 +222311,130 @@ + Any organ component layer that consists of muscle tissue. + FMA:45634 + NCIT:C75444 + UMLS:C0225358 layer of muscle tissue + + + + Any organ component layer that consists of muscle tissue. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A muscular coat that is part of a digestive tract. + muscular coat of digestive tract + + + + + A muscular coat that is part of a digestive tract. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An bone foramen in the ethmoid bone. + Wikipedia:Ethmoidal_foramina + Taxon nodes: In humans, refers to anterior or posterior ethmoid foramina + ethmoid foramen + + + + + An bone foramen in the ethmoid bone. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + The anatomical space within the intestine. + FMA:14586 + TADS:0000495 + WBbt:0005791 + ZFA:0005807 + lumen of intestine + + + + + The anatomical space within the intestine. + http://orcid.org/0000-0002-6601-2165 + @@ -140295,8 +222465,16 @@ + Muscle innervated by the trigeminal nerve (Cranial Nerve V). + MFMO:0000072 trigeminal nerve muscle + + + + Muscle innervated by the trigeminal nerve (Cranial Nerve V). + MFMO:0000072 + @@ -140321,6 +222499,7 @@ + FMA:83450 cardiac muscle tissue of ventricle @@ -140348,8 +222527,86 @@ + An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart. + FMA:73747 + ZFA:0005811 heart vasculature + + + + An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart. + ZFA:0005811 + ZFA:CVS + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + dorsal side of post-anal tail + + + + + + + + + + + + + + + + + + + + + + A membranous sac in animals that serves as the receptacle of a liquid or contains gas. + BTO:0000123 + bladder organ + + + + + A membranous sac in animals that serves as the receptacle of a liquid or contains gas. + BTO:0000123 + @@ -140369,6 +222626,7 @@ + BTO:0002439 reproductive system mucosa @@ -140395,8 +222653,16 @@ + Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes. + BTO:0004043 intramuscular adipose tissue + + + + Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes. + BTO:0004043 + @@ -140421,11 +222687,44 @@ + BTO:0004626 carotid artery endothelium + + + + + + + + + + + + + + + + + + + + + + + + + BTO:0004638 + FMA:13119 + SCTID:88410004 + mucous gland of lung + + + + @@ -140447,8 +222746,16 @@ + Any region of epithelium that is part of a skin region. + BTO:0004382 skin epithelium + + + + Any region of epithelium that is part of a skin region. + http://orcid.org/0000-0002-6601-2165 + @@ -140476,8 +222783,17 @@ + The part of the eye that consists of both the retina and the optic choroid. + SCTID:110701000 chorioretinal region + + + + The part of the eye that consists of both the retina and the optic choroid. + UBERON:drseb + http://orcid.org/0000-0002-6601-2165 + @@ -140502,7 +222818,8 @@ - + DHBA:10654 + FMA:268630 gray matter of hindbrain @@ -140529,7 +222846,8 @@ - + DHBA:10649 + FMA:83913 gray matter of midbrain @@ -140556,6 +222874,8 @@ + EMAPA:35952 + MA:0003174 sensory organ epithelium @@ -140577,8 +222897,16 @@ + An exocrine gland that is part of a integumental system. exocrine gland of integumental system + + + + An exocrine gland that is part of a integumental system. + GOC:dos + http://orcid.org/0000-0002-6601-2165 + @@ -140603,11 +222931,41 @@ + FMA:58315 surface of eyeball + + + + + + + + + + + + + + + + + + + + + + + NCIT:C33596 + SCTID:282511007 + splenic arteriole + + + + @@ -140629,8 +222987,15 @@ + A portion of organism substance that is secreted by a reproductive gland. reproductive gland secretion + + + + A portion of organism substance that is secreted by a reproductive gland. + UBERON:cjm + @@ -140665,8 +223030,16 @@ + Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]. + NLX:149357 nervous system cell part layer + + + + Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]. + NLX:149357 + @@ -140702,8 +223075,16 @@ + Serous membrane layer that is adjacent to and lines an organ. + FMA:15860 visceral serous membrane + + + + Serous membrane layer that is adjacent to and lines an organ. + http://orcid.org/0000-0002-6601-2165 + @@ -140739,8 +223120,17 @@ + Serous membrane layer that lines to a body cavity. + FMA:15859 + MA:0002448 parietal serous membrane + + + + Serous membrane layer that lines to a body cavity. + http://orcid.org/0000-0002-6601-2165 + @@ -140772,8 +223162,17 @@ + A specific region of the foregut into the area in which the lung will develop. + SCTID:34922002 lung field + + + + A specific region of the foregut into the area in which the lung will develop. + GOC:dph + GOC:mtg_lung + @@ -140787,8 +223186,20 @@ + An embryonic or larval epithelium that is committed to form part of the nervous system. + AEO:0001008 + BTO:0000314 + EHDAA2_RETIRED:0004654 + FMA:64807 developing neuroepithelium + + + + An embryonic or larval epithelium that is committed to form part of the nervous system. + AEO:0001008 + AEO:JB + @@ -140796,8 +223207,16 @@ + An epithelium that is undergoing proliferation to provide large numbers of neuronal cells. + AEO:0001009 proliferating neuroepithelium + + + + An epithelium that is undergoing proliferation to provide large numbers of neuronal cells. + AEO:0001009 + @@ -140811,8 +223230,16 @@ + A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells. + AEO:0001010 differentiating neuroepithelium + + + + A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells. + AEO:0001010 + @@ -140838,6 +223265,8 @@ + DHBA:12694 + EMAPA:32916 hindbrain marginal layer @@ -140870,6 +223299,8 @@ + EHDAA2:0001267 + EMAPA:17585 spinal cord ventricular layer @@ -140898,9 +223329,16 @@ - + Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain. cranial neuron projection bundle + + + + Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain. + ISBN:0471888893 + http://orcid.org/0000-0002-6601-2165 + @@ -140926,9 +223364,19 @@ - + The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa. + FMA:5866 + MESH:D017776 + SCTID:276145003 + Wikipedia:Autonomic_nerve autonomic nerve + + + + The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa. + Wikipedia:Autonomic_nerve + @@ -140959,7 +223407,7 @@ - + SCTID:181098007 sympathetic nerve @@ -140969,6 +223417,8 @@ + FMA:79770 + NCIT:C41168 lymphomyeloid tissue @@ -140995,8 +223445,16 @@ + Any substance in the body or expelled from the body that is in a gaseous state. + FMA:84580 bodily gas + + + + Any substance in the body or expelled from the body that is in a gaseous state. + http://orcid.org/0000-0002-6601-2165 + @@ -141025,8 +223483,16 @@ + Any portion of gas located in a part of the respiratory system that is composed primarily of air. + FMA:84581 air in respiratory system + + + + Any portion of gas located in a part of the respiratory system that is composed primarily of air. + http://orcid.org/0000-0002-6601-2165 + @@ -141061,8 +223527,15 @@ + The area of axial mesoderm that develops into the prechordal plate. prechordal mesoderm + + + + The area of axial mesoderm that develops into the prechordal plate. + MGI:anna + @@ -141087,8 +223560,18 @@ + Endocardium that is part of the left atrium. + FMA:7286 + SCTID:190064008 + VHOG:0001226 left atrium endocardium + + + + Endocardium that is part of the left atrium. + http://orcid.org/0000-0002-6601-2165 + @@ -141128,11 +223611,16 @@ - - - + An multicellular anatomical structure that has subparts of multiple organs as a part. + CARO:0020001 multi organ part structure + + + + An multicellular anatomical structure that has subparts of multiple organs as a part. + CARO:0020001 + @@ -141146,11 +223634,17 @@ - - - + A cluster of cells, largely surrounded by a morphological boundary. + CARO:0020002 + FMA:62807 cell cluster + + + + A cluster of cells, largely surrounded by a morphological boundary. + CARO:0020002 + @@ -141177,11 +223671,16 @@ - - - + Material anatomical entity consisting of multiple anatomical structures that are not connected to each other. + CARO:0020000 disconnected anatomical group + + + + Material anatomical entity consisting of multiple anatomical structures that are not connected to each other. + CARO:0020000 + @@ -141195,11 +223694,15 @@ - - - + A collection of anatomical structures that are alike in terms of their morphology or developmental origin. anatomical collection + + + + A collection of anatomical structures that are alike in terms of their morphology or developmental origin. + http://orcid.org/0000-0002-6601-2165 + @@ -141237,8 +223740,51 @@ + A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures. external soft tissue zone + + + + A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts. + BTO:0001513 + epithelium of biliary system + + + + + The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts. + BTO:0001513 + MGI:cs + http://orcid.org/0000-0002-6601-2165 + @@ -141263,8 +223809,15 @@ + Any organ component layer that consists of smooth muscle tissue. layer of smooth muscle tissue + + + + Any organ component layer that consists of smooth muscle tissue. + http://orcid.org/0000-0002-6601-2165 + @@ -141272,11 +223825,75 @@ + FMA:55268 zone of organ + + + + + + + + + + + + + + + + + Any gaseous product of an excretory process. + excreted gas + + + + + Any gaseous product of an excretory process. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Any excreted gas that is produced by the digestive tract. + FMA:78440 + In mammals, mostly produced as a byproduct of bacterial fermentation in the gastrointestinal (GI) tract, especially the colon, and excreted through the rectum + gas excreted from digestive tract + + + + + Any excreted gas that is produced by the digestive tract. + http://orcid.org/0000-0002-6601-2165 + + + + @@ -141298,8 +223915,15 @@ + Any portion of gas located in a part of the respiratory system. gas in respiratory system + + + + Any portion of gas located in a part of the respiratory system. + http://orcid.org/0000-0002-6601-2165 + @@ -141324,6 +223948,8 @@ + NCIT:C25787 + UMLS:C1512086 epithelial layer of duct @@ -141350,8 +223976,17 @@ + Mesenchyme that is part of a developing jaw [Automatically generated definition]. + EMAPA:32907 + EMAPA:35454 jaw mesenchyme + + + + Mesenchyme that is part of a developing jaw [Automatically generated definition]. + OBOL:automatic + @@ -141376,11 +224011,40 @@ + EMAPA:32904 + MA:0003220 jaw epithelium + + + + + + + + + + + + + + + + + + + + + + SCTID:277967008 + rectal artery + + + + @@ -141411,8 +224075,15 @@ + Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included. material entity in digestive tract + + + + Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included. + https://github.com/EnvironmentOntology/envo/issues/110 + @@ -141437,8 +224108,19 @@ + Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface. + FMA:61695 + NCIT:C29667 + SCTID:261060002 + UMLS:C0489451 entire surface of organism + + + + Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface. + FMA:61695 + @@ -141463,6 +224145,10 @@ + FMA:70505 + NCIT:C32552 + SCTID:244216003 + UMLS:C0447038 branch of external carotid artery @@ -141502,9 +224188,19 @@ - + Any of several arteries that arise from the aorta and supply blood to the esophagus. + FMA:4149 + NCIT:C32535 + SCTID:56548006 + UMLS:C0226294 esophageal artery + + + + Any of several arteries that arise from the aorta and supply blood to the esophagus. + ncithesaurus:Esophageal_Artery + @@ -141529,11 +224225,40 @@ + FMA:51797 + SCTID:149683007 uveal vein + + + + + + + + + + + + + + + + + + + + + + SCTID:77852007 + colic artery + + + + @@ -141561,9 +224286,16 @@ - + The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin. + FMA:225275 vasculature of integument + + + + The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin. + http://orcid.org/0000-0002-6601-2165 + @@ -141588,8 +224320,20 @@ + Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers. + FMA:76719 + NCIT:C33666 + SCTID:341382008 + UMLS:C0226513 + Wikipedia:Superficial_vein superficial vein + + + + Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers. + ncithesaurus:Superficial_Vein + @@ -141614,8 +224358,15 @@ + The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin. deep vasculature + + + + The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin. + http://orcid.org/0000-0002-6601-2165 + @@ -141640,8 +224391,20 @@ + A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery. + FMA:76718 + NCIT:C32444 + SCTID:341484008 + UMLS:C0226514 + Wikipedia:Deep_vein deep vein + + + + A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery. + ncithesaurus:Deep_Vein + @@ -141667,8 +224430,17 @@ + Any chamber of the left side of the heart. + FMA:7166 + SCTID:362008007 left cardiac chamber + + + + Any chamber of the left side of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -141694,8 +224466,17 @@ + Any chamber of the right side of the heart. + FMA:7165 + SCTID:362007002 right cardiac chamber + + + + Any chamber of the right side of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -141709,8 +224490,23 @@ + The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. + FMA:76554 + NCIT:C32574 + SCTID:120612006 + UMLS:C0229243 + Wikipedia:Accessory_visual_structures ocular adnexa + + + + The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. + HPO:pr + UBERON:cjm + http://medical-dictionary.thefreedictionary.com/ocular+adnexa + https://github.com/obophenotype/uberon/issues/1132 + @@ -141741,6 +224537,8 @@ + EHDAA2:0004181 + FMA:9464 cavity of cardiac chamber @@ -141767,6 +224565,9 @@ + FMA:223208 + NCIT:C12930 + UMLS:C1512970 intrapulmonary bronchus @@ -141794,8 +224595,50 @@ + The primordial mouth region of the developing head. + FMA:293105 future mouth + + + + The primordial mouth region of the developing head. + MP:0003119 + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of the sigmoid colon. + FMA:15028 + muscle layer of sigmoid colon + + + + + A muscle layer that is part of the sigmoid colon. + https://github.com/obophenotype/uberon/issues/1162 + @@ -141820,6 +224663,8 @@ + FMA:12241 + SCTID:304404008 serous cavity @@ -141846,8 +224691,17 @@ + The sum of epicardial and paracardial fat deposits. + SCTID:42267001 + ZFA:0005765 pericardial fat + + + + The sum of epicardial and paracardial fat deposits. + DOI:10.5935/abc.20130138 + @@ -141876,8 +224730,15 @@ + Fat deposits in the mediastinum outside the parietal pericardium . paracardial fat + + + + Fat deposits in the mediastinum outside the parietal pericardium . + DOI:10.5935/abc.20130138 + @@ -141902,8 +224763,15 @@ + Any fat deposit surrounding a visceral organ. visceral fat + + + + Any fat deposit surrounding a visceral organ. + UBERON:cjm + @@ -141938,8 +224806,17 @@ + The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity. + FMA:12267 + Wikipedia:Abdominopelvic_cavity abdominopelvic cavity + + + + The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity. + UBERON:cjm + @@ -141966,8 +224843,17 @@ + A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity. + EMAPA:16137 + FMA:9908 peritoneal sac + + + + A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity. + https://github.com/obophenotype/uberon/issues/86 + @@ -141999,6 +224885,8 @@ + BTO:0004378 + FMA:67473 wall of blood vessel @@ -142035,6 +224923,7 @@ + EHDAA2:0004070 respiratory primordium epithelium @@ -142068,6 +224957,7 @@ + EHDAA2:0004071 respiratory primordium mesenchyme @@ -142080,8 +224970,16 @@ + An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles. cardiopharyngeal field + + + + An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles. + http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1 + https://orcid.org/0000-0003-3308-6245 + @@ -142101,11 +224999,59 @@ + FMA:83520 fibroelastic connective tissue + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical junction that is between the sigmoid colon and rectum. + NCIT:C54188 + SCTID:245429006 + rectosigmoid junction + + + + + An anatomical junction that is between the sigmoid colon and rectum. + NCIT:C54188 + https://github.com/obophenotype/uberon/issues/1319 + https://www.cdc.gov/cancer/npcr/pdf/abstracting/colon.pdf + + + + @@ -142116,11 +225062,17 @@ - - - + Material anatomical entity that forms the outermost boundary of an anatomical structure. + AAO:0010270 + ZFA:0005594 anatomical surface region + + + + Material anatomical entity that forms the outermost boundary of an anatomical structure. + https://github.com/obophenotype/uberon/issues/1324 + @@ -142145,8 +225097,17 @@ + A bodily fluid that is located in the coelom. + BTO:0001708 coelomic fluid + + + + A bodily fluid that is located in the coelom. + PMID:10874572 + https://github.com/obophenotype/uberon/issues/1326 + @@ -142171,8 +225132,15 @@ + Any gland that is part os the respiratory system. respiratory system gland + + + + Any gland that is part os the respiratory system. + UBERON:cjm + @@ -142197,13 +225165,15 @@ - - - - - + A notochord that has persisted beyond the embryonic stage. post-embryonic notochord + + + + A notochord that has persisted beyond the embryonic stage. + UBERON:cjm + @@ -142234,8 +225204,16 @@ + A transudate found in the serous sac. + FMA:20932 secretion of serous membrane + + + + A transudate found in the serous sac. + FMA:20932 + @@ -142260,6 +225238,7 @@ + FMA:53133 orifice of skull @@ -142275,8 +225254,18 @@ + The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit. + FMA:52972 + SCTID:280243001 + Wikipedia:Zygomaticotemporal_nerve zygomaticotemporal nerve + + + + The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit. + Wikipedia:Zygomaticotemporal_nerve + @@ -142301,8 +225290,16 @@ + Wall of ventricle which is continuous with the wall of aorta. + FMA:9556 wall of left ventricle + + + + Wall of ventricle which is continuous with the wall of aorta. + FMA:9556 + @@ -142327,8 +225324,16 @@ + Wall of ventricle which is continuous with the wall of pulmonary trunk. + FMA:9533 wall of right ventricle + + + + Wall of ventricle which is continuous with the wall of pulmonary trunk. + FMA:9533 + @@ -142359,6 +225364,7 @@ + FMA:9560 anterior wall of left ventricle @@ -142385,8 +225391,16 @@ + Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle. + FMA:9553 anterior wall of right ventricle + + + + Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle. + FMA:9553 + @@ -142411,6 +225425,7 @@ + FMA:87177 myocardium of anterior wall of left ventricle @@ -142437,6 +225452,7 @@ + FMA:260877 myocardium of anterior wall of right ventricle @@ -142463,8 +225479,45 @@ + A mucosa that is part of a lip region [Automatically generated definition]. + NCIT:C12226 mucosa of lip + + + + A mucosa that is part of a lip region [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:225251 + SCTID:297287005 + vasculature of spleen + @@ -142506,11 +225559,40 @@ + FMA:259905 vasculature of central nervous system + + + + + + + + + + + + + + + + + + + + + + + FMA:14657 + wall of gallbladder + + + + @@ -142532,6 +225614,7 @@ + FMA:15089 wall of brachiocephalic artery @@ -142558,11 +225641,44 @@ + FMA:15090 wall of subclavian artery + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:15704 + wall of anal canal + + + + @@ -142584,6 +225700,7 @@ + FMA:18211 wall of pulmonary artery @@ -142611,6 +225728,7 @@ + FMA:231590 wall of synovial tendon sheath @@ -142638,11 +225756,41 @@ + FMA:58098 wall of eyeball + + + + + + + + + + + + + + + + + + + + + + + + FMA:63144 + wall of orbit + + + + @@ -142664,6 +225812,7 @@ + FMA:66284 wall of common carotid artery @@ -142703,8 +225852,124 @@ + Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees. + FMA:7274 wall of heart + + + + Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees. + FMA:7274 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An artery that supplies oxygenated blood to the cystic duct. + FMA:14835 + cystic artery + + + + + An artery that supplies oxygenated blood to the cystic duct. + http://orcid.org/0000-0002-6601-2165 + https://en.wikipedia.org/wiki/Cystic_artery + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:15395 + sigmoid vein + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:70471 + pancreatic artery + @@ -142735,8 +226000,16 @@ + Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament. + FMA:14342 right ovarian vein + + + + Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament. + FMA:14342 + @@ -142761,8 +226034,16 @@ + Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament. + FMA:14347 left ovarian vein + + + + Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament. + FMA:14347 + @@ -142787,8 +226068,55 @@ + A zone of skin that is part of the face. + EMAPA:36657 + FMA:24758 + NCIT:C33561 + SCTID:361703006 skin of face + + + + A zone of skin that is part of the face. + UBERON:EJS + https://github.com/obophenotype/uberon/issues/34 + + + + + + + + + + + + + + + + + + + + + + + + + + + A parenchyma that is part of a spleen. + FMA:16029 + parenchyma of spleen + + + + + A parenchyma that is part of a spleen. + OBOL:automatic + @@ -142813,8 +226141,25 @@ + An anatomical junction between two parts of the digestive tract. digestive tract junction + + + + An anatomical junction between two parts of the digestive tract. + https://orcid.org/0000-0002-7073-9172 + + + + + + + + + ZFA:0001073 + axial vasculature + @@ -142839,8 +226184,16 @@ + Cartilage which is part of the axial skeleton. + ZFA:0001457 postcranial axial cartilage + + + + Cartilage which is part of the axial skeleton. + ZFIN:curator + @@ -142849,8 +226202,21 @@ + Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse. + FMA:63196 + NCIT:C32595 + TAO:0005260 + Wikipedia:Capillary#Types + ZFA:0005260 fenestrated capillary + + + + Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse. + Wikipedia:Capillary#Types + Wikipedia:Fenestra_(histology) + @@ -142858,8 +226224,16 @@ + Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes. + ZFA:0007013 preplacodal ectoderm + + + + Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes. + ZFIN:curator + @@ -142884,8 +226258,16 @@ + Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. + Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305 external integument structure + + + + Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. + AAO:EJS + @@ -142910,8 +226292,15 @@ + Dermal, epidermal, glandular and pigment structures of the external head integument. head external integument structure + + + + Dermal, epidermal, glandular and pigment structures of the external head integument. + AAO:EJS + @@ -142936,8 +226325,48 @@ + Dermal, epidermal, glandular and pigment structures of the body integument. body external integument structure + + + + Dermal, epidermal, glandular and pigment structures of the body integument. + AAO:EJS + + + + + + + + + + + + + + + + + + + + + + + + + + Dermal, epidermal, glandular and pigment structures of the tail integument. + tail external integument structure + + + + + Dermal, epidermal, glandular and pigment structures of the tail integument. + AAO:EJS + @@ -142966,8 +226395,15 @@ + Blood vessels in respiratory skin. vasculature of respiratory integument + + + + Blood vessels in respiratory skin. + AAO:EJS + @@ -142992,8 +226428,15 @@ + An anatomical surface that is part of a bone. surface of bone + + + + An anatomical surface that is part of a bone. + PHENOSCAPE + @@ -143045,8 +226488,15 @@ + Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. left side of back + + + + Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. + https://microbiomedb.org/ + @@ -143072,8 +226522,15 @@ + Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. right side of back + + + + Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. + https://microbiomedb.org/ + @@ -143094,8 +226551,556 @@ + A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles. Purkinje fiber network + + + + A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles. + PMID:26786210 + + + + + + + + + + + + + + + + + + + + + + + + + + + Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact. + liver serosa + + + + + Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact. + https://medical-dictionary.thefreedictionary.com/serosa+of+liver + https://orcid.org/0000-0002-0449-2730 + + + + + + + + + + + + + + + + + + + + + + + + + + + Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson. + liver subserosa + + + + + Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson. + FMA:15812 + https://medical-dictionary.thefreedictionary.com/subserosa+of+liver + https://orcid.org/0000-0002-0449-2730 + + + + + + + + + + + + + + + + + + + + + + + + + + Venule of villus of small intestine. + small intestine venule + + + + + Venule of villus of small intestine. + https://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + Arteriole of villus of small intestine. + small intestine arteriole + + + + + Arteriole of villus of small intestine. + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A venule that is located in the anorectum. + venule of anorectum + + + + + A venule that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + An arteriole that is located in the anorectum. + arteriole of anorectum + + + + + An arteriole that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + An arteriole located in the colon. + arteriole of colon + + + + + An arteriole located in the colon. + http://orcid.org/0000-0003-3440-1876 + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical junction between two parts of the intestine. + intestinal junction + + + + + An anatomical junction between two parts of the intestine. + https://orcid.org/0000-0002-7073-9172 + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosal gland located in a bronchus. + bronchus submucosal gland + + + + + A submucosal gland located in a bronchus. + http://orcid.org/0000-0003-3440-1876 + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A venule located in the colon. + venule of colon + + + + + A venule located in the colon. + https://orcid.org/0000-0003-3440-1876 + https://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus. + anorectum + + + + + A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus. + DOI:10.1007/978-3-319-26938-2_8 + DOI:10.1148/rg.2015150037 + PMID:29742860 + http://orcid.org/0000-0002-6826-8770 + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A capillary that is part of the anorectum. + capillary of anorectum + + + + + A capillary that is part of the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A capillary that is part of the colon. + capillary of colon + + + + + A capillary that is part of the colon. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A capillary that is part of a small intestine. + capillary of small intestine + + + + + A capillary that is part of a small intestine. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosal gland found in a respiratory tract. + EFO:0010666 + airway submucosal gland + + + + + A submucosal gland found in a respiratory tract. + http://orcid.org/0000-0003-3440-1876 + http://orcid.org/0000-0003-4183-8865 + @@ -143104,8 +227109,16 @@ + Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins. blood microvessel + + + + Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins. + Wikipedia:Microcirculation + http://orcid.org/0000-0002-7073-9172 + @@ -143119,8 +227132,15 @@ + Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin). noradrenergic cell groups + + + + Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin). + WikipediaVersioned:Noradrenergic_cell_groups&oldid=965992184 + @@ -143145,9 +227165,15 @@ - + An anatomical system that eliminates waste products that arise as a result of metabolic activity. excretory system + + + + An anatomical system that eliminates waste products that arise as a result of metabolic activity. + GO:0007588 + @@ -143167,8 +227193,15 @@ + A capillary that is part of the brain. capillary of brain + + + + A capillary that is part of the brain. + https://orcid.org/0000-0002-0819-0473 + @@ -143193,8 +227226,15 @@ + A portion of smooth muscle tissue that is part of the thoracic aorta. thoracic aorta smooth muscle tissue + + + + A portion of smooth muscle tissue that is part of the thoracic aorta. + https://orcid.org/0000-0002-0819-0473 + @@ -143219,8 +227259,15 @@ + A zone of skin that is above the clavicle zone in the pectoral girdle region. skin of clavicle region + + + + A zone of skin that is above the clavicle zone in the pectoral girdle region. + https://orcid.org/0000-0002-0819-0473 + @@ -143246,8 +227293,15 @@ + A zone of skin that is part of the external genitalia. skin of external genitalia + + + + A zone of skin that is part of the external genitalia. + https://orcid.org/0000-0002-0819-0473 + @@ -143273,8 +227327,15 @@ + A zone of skin part of some gonad. skin of gonad + + + + A zone of skin part of some gonad. + https://orcid.org/0000-0002-0819-0473 + @@ -143288,8 +227349,25 @@ + A muscle tissue that is associated with soft internal organs (viscera). + It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated. visceral muscle tissue + + + + A muscle tissue that is associated with soft internal organs (viscera). + BTO:0002780 + CLAO:0001295 + + + + + It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated. + FBbt:00005070 + https://en.wikipedia.org/wiki/Smooth_muscle + PMID:8720463 + @@ -143298,8 +227376,52 @@ + A striated muscle tissue that is associated with soft internal organs (viscera). visceral striated muscle tissue + + + + A striated muscle tissue that is associated with soft internal organs (viscera). + PMID:8720463 + https://pressbooks.pub/rbtallitsch/chapter/chapter-6-muscle-tissue/ + + + + + + + + + + + + + + + + + + + + + + + + + + A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium. + submucosal gland acinus + + + + + A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium. + PMID:17394068 + PMID:17707699 + PMID:25648514 + PMID:30864819 + @@ -143320,9 +227442,26 @@ - + A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface. + A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung. bronchopulmonary segment + + + + A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface. + FMA:7312 + PMID:18271171 + PMID:33620799 + doi:10.1016/j.mpaic.2008.09.022 + + + + + A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung. + PMID:18271171 + doi:10.1016/j.mpaic.2008.09.022 + @@ -143361,8 +227500,16 @@ + A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa. pulmonary venule + + + + A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa. + PMID:22283705 + PMID:30247823 + @@ -143404,6 +227551,16 @@ + + + + + + + + + + @@ -143414,6 +227571,37 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -143669,6 +227857,21 @@ + + + + + + + + + + + + + + + @@ -143759,6 +227962,51 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + diff --git a/clm-simple.json b/clm-simple.json index 3bfa2be..3893060 100644 --- a/clm-simple.json +++ b/clm-simple.json @@ -13,18 +13,27 @@ "val" : "Cell Markers Ontology" }, { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", - "val" : "2024-07-26" + "val" : "2024-07-29" } ], - "version" : "http://purl.obolibrary.org/obo/clm/releases/2024-07-26/clm-simple.json" + "version" : "http://purl.obolibrary.org/obo/clm/releases/2024-07-29/clm-simple.json" }, "nodes" : [ { "id" : "http://purl.obolibrary.org/obo/CLM_0000000", - "lbl" : "root node", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000051", "lbl" : "has part", "type" : "PROPERTY", + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "BFO:0000051" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0015004", + "lbl" : "has characterizing marker set", + "type" : "PROPERTY", "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/STATO_0000663", @@ -45,6 +54,11 @@ "lbl" : "title", "type" : "PROPERTY", "propertyType" : "ANNOTATION" + }, { + "id" : "http://www.geneontology.org/formats/oboInOwl#hasDbXref", + "lbl" : "database_cross_reference", + "type" : "PROPERTY", + "propertyType" : "ANNOTATION" } ] } ] } \ No newline at end of file diff --git a/clm-simple.obo b/clm-simple.obo index a1c9ba3..0512a67 100644 --- a/clm-simple.obo +++ b/clm-simple.obo @@ -1,18 +1,20 @@ format-version: 1.2 -data-version: clm/releases/2024-07-26/clm-simple.owl +data-version: clm/releases/2024-07-29/clm-simple.owl +idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# idspace: terms http://purl.org/dc/terms/ ontology: clm/clm-simple -property_value: owl:versionInfo "2024-07-26" xsd:string +property_value: owl:versionInfo "2024-07-29" xsd:string property_value: terms:description "None" xsd:string property_value: terms:license https://creativecommons.org/licenses/unspecified property_value: terms:title "Cell Markers Ontology" xsd:string -[Term] -id: CLM:0000000 -name: root node - [Typedef] id: BFO:0000051 name: has part +xref: BFO:0000051 is_transitive: true +[Typedef] +id: RO:0015004 +name: has characterizing marker set + diff --git a/clm-simple.owl b/clm-simple.owl index 31064b0..f2a170a 100644 --- a/clm-simple.owl +++ b/clm-simple.owl @@ -7,13 +7,14 @@ xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" - xmlns:terms="http://purl.org/dc/terms/"> + xmlns:terms="http://purl.org/dc/terms/" + xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + None Cell Markers Ontology - 2024-07-26 + 2024-07-29 @@ -59,6 +60,14 @@ + + + + database_cross_reference + + + + + + + has characterizing marker set + + + + - - root node - + diff --git a/clm.json b/clm.json index 5284a03..c838425 100644 --- a/clm.json +++ b/clm.json @@ -13,51 +13,65 @@ "val" : "Cell Markers Ontology" }, { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", - "val" : "2024-07-26" + "val" : "2024-07-29" } ], - "version" : "http://purl.obolibrary.org/obo/clm/releases/2024-07-26/clm.json" + "version" : "http://purl.obolibrary.org/obo/clm/releases/2024-07-29/clm.json" }, "nodes" : [ { - "id" : "http://identifiers.org/ncbigene/11065", + "id" : "http://identifiers.org/ensembl/ENSG00000038945", + "lbl" : "MSR1", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/2168", + "id" : "http://identifiers.org/ensembl/ENSG00000050730", + "lbl" : "TNIP3", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/286133", + "id" : "http://identifiers.org/ensembl/ENSG00000100292", + "lbl" : "HMOX1", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/3162", + "id" : "http://identifiers.org/ensembl/ENSG00000131471", + "lbl" : "AOC3", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/3248", + "id" : "http://identifiers.org/ensembl/ENSG00000137804", + "lbl" : "NUSAP1", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/4060", + "id" : "http://identifiers.org/ensembl/ENSG00000139329", + "lbl" : "LUM", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/4481", + "id" : "http://identifiers.org/ensembl/ENSG00000163735", + "lbl" : "CXCL5", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/51203", + "id" : "http://identifiers.org/ensembl/ENSG00000164120", + "lbl" : "HPGD", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/57124", + "id" : "http://identifiers.org/ensembl/ENSG00000166803", + "lbl" : "PCLAF", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/6241", + "id" : "http://identifiers.org/ensembl/ENSG00000168079", + "lbl" : "SCARA5", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/6374", + "id" : "http://identifiers.org/ensembl/ENSG00000170323", + "lbl" : "FABP4", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/79931", + "id" : "http://identifiers.org/ensembl/ENSG00000171848", + "lbl" : "RRM2", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/8639", + "id" : "http://identifiers.org/ensembl/ENSG00000174807", + "lbl" : "CD248", "type" : "CLASS" }, { - "id" : "http://identifiers.org/ncbigene/9768", + "id" : "http://identifiers.org/ensembl/ENSG00000175063", + "lbl" : "UBE2C", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000002", @@ -86,21 +100,36 @@ }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_16646", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_16990", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_16991", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_17087", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_17089", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_17544", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_18059", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_18085", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_18133", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_18154", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_22868", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_24431", "type" : "CLASS" @@ -119,12 +148,21 @@ }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_26764", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_28087", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_28938", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_29067", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_30212", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_3098", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_32952", "type" : "CLASS" @@ -152,15 +190,39 @@ }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_350546", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_35341", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_35352", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_35406", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_35722", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_35757", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_36080", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_36235", + "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_36277", + "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_37163", + "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_37395", + "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_4167", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_50994", "type" : "CLASS" @@ -179,6 +241,9 @@ }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_64628", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CHEBI_64709", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CHEBI_6495", "type" : "CLASS" @@ -187,116 +252,328 @@ "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CLM_0000000", - "lbl" : "root node", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000000", "lbl" : "cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.", + "xrefs" : [ "CARO:mah" ] + }, + "comments" : [ "A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26.", "The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one)." ], + "xrefs" : [ { + "val" : "CALOHA:TS-2035" + }, { + "val" : "FMA:68646" + }, { + "val" : "GO:0005623" + }, { + "val" : "KUPO:0000002" + }, { + "val" : "MESH:D002477" + }, { + "val" : "VHOG:0001533" + }, { + "val" : "WBbt:0004017" + }, { + "val" : "XAO:0003012" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000005", "lbl" : "neural crest derived fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is derived from the neural crest.", + "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000006", "lbl" : "neuronal receptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000007", "lbl" : "early embryonic cell (metazoa)", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell found in the embryo before the formation of all the gem layers is complete.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000008", "lbl" : "migratory cranial neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination.", + "xrefs" : [ "ZFA:0007091", "https://orcid.org/0000-0001-5208-3432" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000011", "lbl" : "migratory trunk neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination.", + "xrefs" : [ "ZFA:0007095", "https://orcid.org/0000-0001-5208-3432" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000014", "lbl" : "germ line stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that is the precursor of gametes.", + "xrefs" : [ "doi:10.1016/j.stem.2012.05.016" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000021", "lbl" : "female germ cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Female germ cell is a germ cell that supports female gamete production.", + "xrefs" : [ "GOC:tfm", "PMID:11023867", "PMID:20454446" ] + }, + "xrefs" : [ { + "val" : "MA:0000388" + }, { + "val" : "VHOG:0001530" + }, { + "val" : "ncithesaurus:Egg" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000022", "lbl" : "female germ line stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that is the precursor of female gametes.", + "xrefs" : [ "doi:10.1016/j.stem.2012.05.016" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000023", "lbl" : "oocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A female germ cell that has entered meiosis.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0000964" + }, { + "val" : "CALOHA:TS-0711" + }, { + "val" : "FMA:18644" + }, { + "val" : "MESH:D009865" + }, { + "val" : "WBbt:0006797" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000024", "lbl" : "oogonial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "FMA:83673" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000025", "lbl" : "egg cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0000369" + }, { + "val" : "BTO:0003801" + }, { + "val" : "CALOHA:TS-2191" + }, { + "val" : "FMA:67343" + }, { + "val" : "MESH:D010063" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000027", "lbl" : "smooth muscle cell neural crest derived", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell derived from the neural crest.", + "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000029", "lbl" : "neural crest derived neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neuron that develops from some migratory neural crest cell.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000031", "lbl" : "neuroblast (sensu Vertebrata)", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that will develop into a neuron often after a migration phase.", + "xrefs" : [ "GOC:NV", "http://en.wikipedia.org/wiki/Neuroblast" ] + }, + "xrefs" : [ { + "val" : "BTO:0000930" + }, { + "val" : "FMA:70563" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000034", "lbl" : "stem cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.", + "xrefs" : [ "GOC:tfm", "MESH:D013234" ] + }, + "comments" : [ "This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’." ], + "xrefs" : [ { + "val" : "CALOHA:TS-2086" + }, { + "val" : "FMA:63368" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000035", "lbl" : "single fate stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that self-renews as well as give rise to a single mature cell type.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70569" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000037", "lbl" : "hematopoietic stem cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.", + "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:19022770", "http://en.wikipedia.org/wiki/Hematopoietic_stem_cell" ] + }, + "comments" : [ "Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative." ], + "xrefs" : [ { + "val" : "BTO:0000725" + }, { + "val" : "CALOHA:TS-0448" + }, { + "val" : "FMA:86475" + }, { + "val" : "MESH:D006412" + }, { + "val" : "VHOG:0001485" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000038", "lbl" : "erythroid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell committed to the erythroid lineage.", + "xrefs" : [ "GOC:add", "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "BTO:0004911" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000039", "lbl" : "germ line cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "comments" : [ "Originally this term had some plant germ line cell children." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000040", "lbl" : "monoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus.", + "xrefs" : [ "GOC:add", "PMID:1104740", "http://en.wikipedia.org/wiki/Monoblast", "http://www.copewithcytokines.de" ] + }, + "comments" : [ "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ], + "xrefs" : [ { + "val" : "CALOHA:TS-1195" + }, { + "val" : "FMA:83553" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000048", "lbl" : "multi fate stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that can give rise to multiple lineages of cells.", + "xrefs" : [ "GOC:add" ] + }, + "xrefs" : [ { + "val" : "FMA:84789" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000049", "lbl" : "common myeloid progenitor", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.", + "xrefs" : [ "GOC:add", "ISBN:0878932437", "MESH:D023461" ] + }, + "comments" : [ "This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059)." ], + "xrefs" : [ { + "val" : "BTO:0004730" } ] } }, { @@ -304,69 +581,169 @@ "lbl" : "megakaryocyte-erythroid progenitor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A progenitor cell committed to the megakaryocyte and erythroid lineages.", + "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "MESH:D055015", "PMID:16647566", "http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell" ] + }, + "comments" : [ "MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000051", "lbl" : "common lymphoid progenitor", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A oligopotent progenitor cell committed to the lymphoid lineage.", + "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:10407577", "PMID:16551251" ] + }, + "comments" : [ "CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000052", "lbl" : "totipotent stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell from which all cells of the body can form.", + "xrefs" : [ "GOC:add", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:84790" + }, { + "val" : "MESH:D039901" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000055", "lbl" : "non-terminally differentiated cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A precursor cell with a limited number of potential fates.", + "xrefs" : [ "SANBI:mhl" ] + }, + "comments" : [ "define using PATO mulit-potent or oligopotent?" ], + "xrefs" : [ { + "val" : "BTO:0000125" + }, { + "val" : "FMA:84782" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000056", "lbl" : "myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair.", + "xrefs" : [ "GOC:tfm", "MESH:D032446", "PMID:21849021" ] + }, + "xrefs" : [ { + "val" : "BTO:0000222" + }, { + "val" : "CALOHA:TS-0650" + }, { + "val" : "FMA:70335" + }, { + "val" : "VHOG:0001529" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000057", "lbl" : "fibroblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.", + "xrefs" : [ "ISBN:0517223651", "MESH:D005347", "http://en.wikipedia.org/wiki/Fibroblast" ] + }, + "comments" : [ "These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative." ], + "xrefs" : [ { + "val" : "BTO:0000452" + }, { + "val" : "CALOHA:TS-0362" + }, { + "val" : "FMA:63877" + }, { + "val" : "NCIT:C12482" + }, { + "val" : "VHOG:0001482" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000058", "lbl" : "chondroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell.", + "xrefs" : [ "GOC:tfm", "GO_REF:0000034", "ISBN:0618947256" ] + }, + "xrefs" : [ { + "val" : "BTO:0003607" + }, { + "val" : "FMA:66783" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000064", "lbl" : "ciliated cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that has a filiform extrusion of the cell surface.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "VHOG:0001532" + }, { + "val" : "XAO:0000031" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000066", "lbl" : "epithelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.", + "xrefs" : [ "FB:ma", "GOC:tfm", "MESH:D004847" ] + }, + "xrefs" : [ { + "val" : "BTO:0000414" + }, { + "val" : "CALOHA:TS-2026" + }, { + "val" : "CARO:0000077" + }, { + "val" : "FMA:66768" + }, { + "val" : "WBbt:0003672" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000067", "lbl" : "ciliated epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell that has a cilia.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70605" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000068", "lbl" : "duct epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell that is part of a duct.", + "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000069", "lbl" : "branched duct epithelial cell", @@ -376,69 +753,152 @@ "lbl" : "blood vessel endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An endothelial cell that lines the vasculature.", + "xrefs" : [ "GOC:tfm" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000075", "lbl" : "columnar/cuboidal epithelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.", + "xrefs" : [ "GO:0002065", "https://orcid.org/0000-0001-5208-3432" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000076", "lbl" : "squamous epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "CALOHA:TS-1249" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000077", "lbl" : "mesothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A flattened epithelial cell of mesenchymal origin that lines the serous cavity.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "FMA:66773" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000080", "lbl" : "circulating cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell which moves among different tissues of the body, via blood, lymph, or other medium.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000081", "lbl" : "blood cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell found predominately in the blood.", + "xrefs" : [ "GOC:add", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:62844" + }, { + "val" : "MESH:D001773" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000082", "lbl" : "epithelial cell of lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the lung.", + "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ] + }, + "xrefs" : [ { + "val" : "BTO:0004299" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000083", + "lbl" : "epithelial cell of pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the pancreas.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0000028" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000084", "lbl" : "T cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.", + "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ] + }, + "xrefs" : [ { + "val" : "BTO:0000782" + }, { + "val" : "CALOHA:TS-1001" + }, { + "val" : "FMA:62870" + }, { + "val" : "MESH:D013601" + }, { + "val" : "VHOG:0001479" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000092", "lbl" : "osteoclast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.", + "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:10428500", "PMID:15055519", "PMID:17380158" ] + }, + "comments" : [ "Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid." ], + "xrefs" : [ { + "val" : "BTO:0000968" + }, { + "val" : "CALOHA:TS-0721" + }, { + "val" : "FMA:66781" + }, { + "val" : "MESH:D010010" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000094", "lbl" : "granulocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A leukocyte with abundant granules in the cytoplasm.", + "xrefs" : [ "GOC:amm", "GOC:tfm", "MESH:D006098", "http://en.wikipedia.org/wiki/Granulocyte" ] + }, + "xrefs" : [ { + "val" : "BTO:0000539" + }, { + "val" : "BTO:0001026" + }, { + "val" : "CALOHA:TS-0422" + }, { + "val" : "FMA:62854" } ] } }, { @@ -448,15 +908,32 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000098", "lbl" : "sensory epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "ISBN:0721662544" ] + }, + "comments" : [ "The term \"neuroepithelial cell\" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710)." ], + "xrefs" : [ { + "val" : "BTO:0004301" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000099", "lbl" : "interneuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.", + "xrefs" : [ "GOC:tfm", "MESH:D007395" ] + }, + "xrefs" : [ { + "val" : "BTO:0003811" + }, { + "val" : "FMA:67313" + }, { + "val" : "WBbt:0005113" } ] } }, { @@ -464,9 +941,16 @@ "lbl" : "motor neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement.", + "xrefs" : [ "MESH:D009046", "PMID:16875686" ] + }, + "xrefs" : [ { + "val" : "BTO:0000312" + }, { + "val" : "FMA:83617" + }, { + "val" : "WBbt:0005409" } ] } }, { @@ -474,23 +958,44 @@ "lbl" : "sensory neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Any neuron having a sensory function; an afferent neuron conveying sensory impulses.", + "xrefs" : [ "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0001037" + }, { + "val" : "FMA:84649" + }, { + "val" : "MESH:D011984" + }, { + "val" : "WBbt:0005759" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000107", "lbl" : "autonomic neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron whose cell body is within an autonomic ganglion.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:80121" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000113", "lbl" : "mononuclear phagocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A vertebrate phagocyte with a single nucleus.", + "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ] + }, + "xrefs" : [ { + "val" : "BTO:0001433" } ] } }, { @@ -498,9 +1003,17 @@ "lbl" : "endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.", + "xrefs" : [ "GOC:tfm", "MESH:D042783", "PMID:21275341", "http://en.wikipedia.org/wiki/Endothelial_cell", "https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855" ] + }, + "comments" : [ "From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]." ], + "xrefs" : [ { + "val" : "BTO:0001176" + }, { + "val" : "CALOHA:TS-0278" + }, { + "val" : "FMA:66772" } ] } }, { @@ -512,41 +1025,105 @@ "lbl" : "glial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.", + "xrefs" : [ "MESH:D009457" ] + }, + "comments" : [ "Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571" ], + "xrefs" : [ { + "val" : "BTO:0002606" + }, { + "val" : "CALOHA:TS-0415" + }, { + "val" : "FMA:54536" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000133", "lbl" : "neurectodermal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ectoderm destined to be nervous tissue.", + "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000134", "lbl" : "mesenchymal stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.", + "xrefs" : [ "FB:ma", "GOC:dsd", "PMCID:PMC2613570", "PMID:10102814", "PMID:16923606", "PMID:17986482", "PMID:19960544", "http://en.wikipedia.org/wiki/Mesenchymal_stem_cell", "http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells" ] + }, + "comments" : [ "Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2." ], + "xrefs" : [ { + "val" : "BTO:0002625" + }, { + "val" : "BTO:0003298" + }, { + "val" : "FMA:70546" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000136", "lbl" : "adipocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.", + "xrefs" : [ "MESH:D017667" ] + }, + "xrefs" : [ { + "val" : "BTO:0000443" + }, { + "val" : "CALOHA:TS-0012" + }, { + "val" : "FMA:63880" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000138", "lbl" : "chondrocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell.", + "xrefs" : [ "GO_REF:0000034", "MESH:D019902" ] + }, + "xrefs" : [ { + "val" : "BTO:0000249" + }, { + "val" : "CALOHA:TS-0138" + }, { + "val" : "FMA:66782" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000145", "lbl" : "professional antigen presenting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000147", "lbl" : "pigment cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pigment cell is a cell that contains pigment granules.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "VHOG:0001678" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000149", "lbl" : "visual pigment cell", @@ -554,35 +1131,89 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000150", "lbl" : "glandular epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2085" + }, { + "val" : "FMA:86494" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000151", "lbl" : "secretory cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that specializes in controlled release of one or more substances.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0003659" + }, { + "val" : "FMA:86916" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000152", "lbl" : "exocrine cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "FMA:16014" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000153", "lbl" : "glycosaminoglycan secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that secretes glycosaminoglycans.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000154", "lbl" : "protein secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some protein secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000157", "lbl" : "surfactant secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that specializes in secretion of surfactant in the alveoli of the lung.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000158", "lbl" : "club cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium.", + "xrefs" : [ "DOI:10.1183/09031936.00146609", "DOI:10.1378/chest.12-2762", "GOC:tfm", "PMID:28128362", "PMID:29874100", "PMID:7905712" ] + }, + "xrefs" : [ { + "val" : "BTO:0004811" + }, { + "val" : "FMA:14119" } ] } }, { @@ -594,57 +1225,221 @@ "lbl" : "endocrine cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.", + "xrefs" : [ "MESH:D055098" ] + }, + "xrefs" : [ { + "val" : "FMA:83809" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000164", "lbl" : "enteroendocrine cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas.", + "xrefs" : [ "GOC:tfm", "SANBI:mhl" ] + }, + "xrefs" : [ { + "val" : "BTO:0003865" + }, { + "val" : "FMA:62930" + }, { + "val" : "MESH:D019858" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000165", "lbl" : "neuroendocrine cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A neuron that is capable of some hormone secretion in response to neuronal signals.", + "xrefs" : [ "MESH:D055099" ] + }, + "comments" : [ "The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron." ], + "xrefs" : [ { + "val" : "BTO:0002691" + }, { + "val" : "FMA:83810" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000167", "lbl" : "peptide hormone secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some peptide hormone secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000168", + "lbl" : "insulin secreting cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some insulin secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "BTO:0000783" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000169", + "lbl" : "type B pancreatic cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that secretes insulin and is located towards the center of the islets of Langerhans.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Pancreatic_b_cell" ] + }, + "comments" : [ "Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression." ], + "xrefs" : [ { + "val" : "BTO:0000783" + }, { + "val" : "EV:0200009" + }, { + "val" : "FMA:70586" + }, { + "val" : "MA:0002419" + }, { + "val" : "ncithesaurus:Beta_Cell" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000170", "lbl" : "glucagon secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that secretes glucagon.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:84045" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000171", + "lbl" : "pancreatic A cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0000990" + }, { + "val" : "FMA:70585" + }, { + "val" : "MESH:D050416" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000172", "lbl" : "somatostatin secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some somatostatin secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000173", + "lbl" : "pancreatic D cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin.", + "xrefs" : [ "FMA:0517223651", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0000803" + }, { + "val" : "FMA:70587" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000174", "lbl" : "steroid hormone secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some steroid hormone secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000182", + "lbl" : "hepatocyte", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated.", + "xrefs" : [ "GOC:tfm", "ISBN:0412046911", "MESH:D022781", "PMID:19717280", "http://en.wikipedia.org/wiki/Hepatocyte" ] + }, + "comments" : [ "Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive." ], + "xrefs" : [ { + "val" : "BTO:0000575" + }, { + "val" : "CALOHA:TS-0454" + }, { + "val" : "FMA:14515" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000183", "lbl" : "contractile cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose primary function is to shorten.", + "xrefs" : [ "FB:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000187", "lbl" : "muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.", + "xrefs" : [ "MESH:D032342" ] + }, + "xrefs" : [ { + "val" : "BTO:0000888" + }, { + "val" : "BTO:0000902" + }, { + "val" : "CALOHA:TS-2032" + }, { + "val" : "FMA:67328" + }, { + "val" : "WBbt:0003675" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000188", "lbl" : "cell of skeletal muscle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A somatic cell located in skeletal muscle.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004392" + }, { + "val" : "CALOHA:TS-2158" + }, { + "val" : "FMA:9727" } ] } }, { @@ -652,9 +1447,16 @@ "lbl" : "smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast).", + "xrefs" : [ "MESH:D032389", "PMID:9315361", "http://en.wikipedia.org/wiki/Smooth_muscle_cell" ] + }, + "xrefs" : [ { + "val" : "BTO:0004576" + }, { + "val" : "CALOHA:TS-2159" + }, { + "val" : "FMA:14072" } ] } }, { @@ -664,24 +1466,58 @@ "meta" : { "definition" : { "val" : "A cell that is capable of detection of a stimulus involved in sensory perception." - } + }, + "xrefs" : [ { + "val" : "MESH:D011984" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000206", "lbl" : "chemoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood.", + "xrefs" : [ "MESH:D002628" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000210", "lbl" : "photoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell specialized to detect and transduce light.", + "xrefs" : [ "MESH:D010786" ] + }, + "xrefs" : [ { + "val" : "BTO:0001060" + }, { + "val" : "CALOHA:TS-0868" + }, { + "val" : "FMA:86740" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000211", "lbl" : "electrically active cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose function is determined by the generation or the reception of an electric signal.", + "xrefs" : [ "FB:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000213", "lbl" : "lining cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism.", + "xrefs" : [ "JB:jb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000214", "lbl" : "synovial cell", @@ -689,86 +1525,209 @@ "meta" : { "definition" : { "val" : "A cell located in the synovial joint." - } + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0995" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000215", "lbl" : "barrier cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose primary function is to prevent the transport of stuff across compartments.", + "xrefs" : [ "JB:jb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000219", "lbl" : "motile cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that moves by its own activities.", + "xrefs" : [ "FB:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000221", "lbl" : "ectodermal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the outer of the three germ layers of the embryo.", + "xrefs" : [ "MESH:D004475" ] + }, + "xrefs" : [ { + "val" : "FMA:72549" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000222", "lbl" : "mesodermal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the middle germ layer of the embryo.", + "xrefs" : [ "MESH:D008648" ] + }, + "xrefs" : [ { + "val" : "FMA:72554" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000223", "lbl" : "endodermal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the inner of the three germ layers of the embryo.", + "xrefs" : [ "MESH:D004707" ] + }, + "xrefs" : [ { + "val" : "FMA:72555" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000226", "lbl" : "single nucleate cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell with a single nucleus.", + "xrefs" : [ "FB:ma", "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000228", "lbl" : "multinucleate cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell with more than one nucleus.", + "xrefs" : [ "FB:ma" ] + }, + "xrefs" : [ { + "val" : "AEO:0000203" + }, { + "val" : "WBbt:0008074" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000232", "lbl" : "erythrocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.", + "xrefs" : [ "GOC:tfm", "MESH:D004912" ] + }, + "xrefs" : [ { + "val" : "BTO:0000424" + }, { + "val" : "CALOHA:TS-0290" + }, { + "val" : "FMA:81100" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000234", "lbl" : "phagocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell capable of ingesting particulate matter via phagocytosis.", + "xrefs" : [ "GOC:add", "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "BTO:0001044" + }, { + "val" : "FMA:83806" + }, { + "val" : "MESH:D010586" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000235", "lbl" : "macrophage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.", + "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "PMID:16213494", "PMID:1919437" ] + }, + "comments" : [ "Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid." ], + "xrefs" : [ { + "val" : "BTO:0000801" + }, { + "val" : "CALOHA:TS-0587" + }, { + "val" : "FMA:63261" + }, { + "val" : "FMA:83585" + }, { + "val" : "MESH:D008264" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000255", "lbl" : "eukaryotic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that only exists in Eukaryota.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "MESH:D005057" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000257", "lbl" : "Eumycetozoan cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that only exists in Eumycetozoa.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000287", "lbl" : "eye photoreceptor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any photoreceptor cell that is part of some eye.", + "xrefs" : [ "FBC:Autogenerated" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000293", "lbl" : "structural cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism.", + "xrefs" : [ "TAIR:sr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000300", "lbl" : "gamete", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mature sexual reproductive cell having a single set of unpaired chromosomes.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0395" + }, { + "val" : "FMA:18649" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000306", "lbl" : "crystallin accumulating cell", @@ -776,19 +1735,72 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000307", "lbl" : "tracheal epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell found in the trachea.", + "xrefs" : [ "GOC:tfm" ] + }, + "comments" : [ "This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'" ], + "xrefs" : [ { + "val" : "FMA:74793" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000313", "lbl" : "serous secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0003687" + }, { + "val" : "FMA:62511" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000319", + "lbl" : "mucus secreting cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is capable of some mucus secretion.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "BTO:0003689" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000322", "lbl" : "pulmonary alveolar epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates.", + "xrefs" : [ "GOC:tfm", "PMID:20054144", "PMID:29463737" ] + }, + "xrefs" : [ { + "val" : "BTO:0000395" + }, { + "val" : "CALOHA:TS-2168" + }, { + "val" : "FMA:62499" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000325", "lbl" : "stuff accumulating cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that is specialised to accumulate a particular substance(s).", + "xrefs" : [ "FB:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000327", "lbl" : "extracellular matrix secreting cell", @@ -796,61 +1808,174 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000329", "lbl" : "oxygen accumulating cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that is capable of some oxygen transport.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000333", "lbl" : "migratory neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body.", + "xrefs" : [ "doi:10.1016/j.stem.2015.02.017" ] + }, + "xrefs" : [ { + "val" : "FMA:86667" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000335", "lbl" : "mesenchyme condensation cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors.", + "xrefs" : [ "GOC:tfm", "PMID:5025404" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000347", "lbl" : "scleral cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the sclera of the eye.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000348", "lbl" : "choroidal cell of the eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structural cell that is part of optic choroid.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000349", "lbl" : "extraembryonic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that is part of some extraembryonic structure.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000351", "lbl" : "trophoblast cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface.", + "xrefs" : [ "GOC:tfm", "MESH:D014327" ] + }, + "xrefs" : [ { + "val" : "FMA:83028" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000352", "lbl" : "epiblast cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation.", + "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000353", "lbl" : "blastoderm cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote).", + "xrefs" : [ "MESH:D001756" ] + }, + "xrefs" : [ { + "val" : "BTO:0001473" + }, { + "val" : "FMA:72551" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000355", "lbl" : "multi-potent skeletal muscle stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell.", + "xrefs" : [ "PMID:18282570" ] + }, + "comments" : [ "Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo." ], + "xrefs" : [ { + "val" : "FMA:86767" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000358", + "lbl" : "sphincter associated smooth muscle cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.", + "xrefs" : [ "GOC:cjm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000359", "lbl" : "vascular associated smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A smooth muscle cell associated with the vasculature.", + "xrefs" : [ "GOC:dsd", "GOC:tfm" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000362", "lbl" : "epidermal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the integument (the outer layer of an organism).", + "xrefs" : [ "Flybase:dsj", "MA:ma" ] + }, + "xrefs" : [ { + "val" : "BTO:0001470" + }, { + "val" : "CALOHA:TS-0283" + }, { + "val" : "FMA:62411" + }, { + "val" : "MESH:D000078404" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000365", "lbl" : "animal zygote", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Diploid cell produced by the fusion of sperm cell nucleus and egg cell.", + "xrefs" : [ "ISBN:0471245208" ] + }, + "xrefs" : [ { + "val" : "BTO:0000854" + }, { + "val" : "EHDAA2:0004546" + }, { + "val" : "FMA:72395" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000377", "lbl" : "tracheoblast", @@ -858,28 +1983,67 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000393", "lbl" : "electrically responsive cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose function is determined by its response to an electric signal.", + "xrefs" : [ "FB:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000397", "lbl" : "ganglion interneuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any interneuron that has its soma located in some ganglion.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000402", "lbl" : "CNS interneuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An interneuron that has its cell body in a central nervous system.", + "xrefs" : [ "doi:10.1016/B978-0-12-817424-1.00001-X" ] + }, + "comments" : [ "Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000404", "lbl" : "electrically signaling cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that initiates an electrical signal and passes that signal to another cell.", + "xrefs" : [ "FB:ma" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000412", + "lbl" : "polyploid cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that contains more than two haploid sets of chromosomes.", + "xrefs" : [ "FB:ma", "PMID:32646579", "https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000413", "lbl" : "haploid cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose nucleus contains a single haploid genome.", + "xrefs" : [ "FB:ma", "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000417", + "lbl" : "endopolyploid cell", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/CL_0000447", @@ -890,9 +2054,18 @@ "lbl" : "dendritic cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "xrefs" : [ { + "val" : "BTO:0002042" + }, { + "val" : "CALOHA:TS-0194" + }, { + "val" : "FMA:83036" + }, { + "val" : "MESH:D003713" } ] } }, { @@ -902,57 +2075,186 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0000458", "lbl" : "serotonin secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell type that secretes 5-Hydroxytryptamine (serotonin).", + "xrefs" : [ "GOC:tfm", "PMID:19630576" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000459", "lbl" : "noradrenergic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme.", + "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000473", "lbl" : "defensive cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose primary function is to protect the organism.", + "xrefs" : [ "JB:jb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000488", "lbl" : "visible light photoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A photoreceptor cell that detects visible light.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000499", "lbl" : "stromal cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.", + "xrefs" : [ "GOC:tfm", "MESH:D017154" ] + }, + "xrefs" : [ { + "val" : "BTO:0002064" + }, { + "val" : "FMA:83624" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000502", + "lbl" : "type D enteroendocrine cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin.", + "xrefs" : [ "MESH:D019864" ] + }, + "xrefs" : [ { + "val" : "FMA:62935" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000506", + "lbl" : "enkephalin secreting cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endorphine cell that secretes enkephalin.", + "xrefs" : [ "GO:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000507", + "lbl" : "endorphin secreting cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A peptide hormone secreting cell that secretes endorphin.", + "xrefs" : [ "GO:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000508", + "lbl" : "type G enteroendocrine cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "MESH:D019863" ] + }, + "xrefs" : [ { + "val" : "BTO:0004108" + }, { + "val" : "FMA:67609" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000509", + "lbl" : "gastrin secreting cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A peptide hormone secreting cell that secretes gastrin.", + "xrefs" : [ "GO:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000513", "lbl" : "cardiac muscle myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A precursor cell destined to differentiate into cardiac muscle cell.", + "xrefs" : [ "GOC:tfm", "MESH:D032386" ] + }, + "xrefs" : [ { + "val" : "FMA:84797" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000514", "lbl" : "smooth muscle myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A precursor cell destined to differentiate into smooth muscle myocytes.", + "xrefs" : [ "GOC:tfm", "MESH:D032390" ] + }, + "xrefs" : [ { + "val" : "FMA:84798" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000515", "lbl" : "skeletal muscle myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myoblast that differentiates into skeletal muscle fibers.", + "xrefs" : [ "SANBI:mhl" ] + }, + "xrefs" : [ { + "val" : "FMA:84799" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000518", "lbl" : "phagocyte (sensu Vertebrata)", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A phagocyte in vertebrates that is able to phagocytosis.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000521", "lbl" : "fungal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that only exists in Fungi.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000525", "lbl" : "syncytiotrophoblast cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.", + "xrefs" : [ "GOC:tfm", "ISBN:0323052908" ] + }, + "xrefs" : [ { + "val" : "FMA:83043" } ] } }, { @@ -960,23 +2262,44 @@ "lbl" : "afferent neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A neuron which conveys sensory information centrally from the periphery.", + "xrefs" : [ "GOC:tfm", "MESH:D009475" ] + }, + "xrefs" : [ { + "val" : "FMA:87653" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000527", "lbl" : "efferent neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron which sends impulses peripherally to activate muscles or secretory cells.", + "xrefs" : [ "MESH:D009476" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000540", "lbl" : "neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.", + "xrefs" : [ "MESH:D009474", "http://en.wikipedia.org/wiki/Neuron" ] + }, + "comments" : [ "These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma." ], + "xrefs" : [ { + "val" : "BTO:0000938" + }, { + "val" : "CALOHA:TS-0683" + }, { + "val" : "FMA:54527" + }, { + "val" : "VHOG:0001483" + }, { + "val" : "WBbt:0003679" } ] } }, { @@ -984,35 +2307,93 @@ "lbl" : "lymphocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.", + "xrefs" : [ "GOC:add", "ISBN:0683073696", "ISBN:0781735149" ] + }, + "comments" : [ "Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)" ], + "xrefs" : [ { + "val" : "BTO:0000775" + }, { + "val" : "CALOHA:TS-0583" + }, { + "val" : "FMA:62863" + }, { + "val" : "MESH:D008214" + }, { + "val" : "VHOG:0001535" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000547", "lbl" : "proerythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.", + "xrefs" : [ "ISBN:0721601464", "PMID:1638021" ] + }, + "xrefs" : [ { + "val" : "FMA:83518" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000549", "lbl" : "basophilic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers.", + "xrefs" : [ "GOC:tfm", "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "FMA:83505" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000550", "lbl" : "polychromatophilic erythroblast", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/CL_0000552", - "lbl" : "orthochromatic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers.", + "xrefs" : [ "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "FMA:83506" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000552", + "lbl" : "orthochromatic erythroblast", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated.", + "xrefs" : [ "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "FMA:84646" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000553", "lbl" : "megakaryocyte progenitor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).", + "xrefs" : [ "GOC:dsd", "GOC:tfm", "ISBN:0721601464" ] + }, + "comments" : [ "Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative." ], + "xrefs" : [ { + "val" : "BTO:0001164" + }, { + "val" : "CALOHA:TS-0610" + }, { + "val" : "FMA:84235" + }, { + "val" : "MESH:D055016" } ] } }, { @@ -1020,9 +2401,17 @@ "lbl" : "megakaryocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release.", + "xrefs" : [ "ISBN:0721601464", "MESH:D008533", "PMID:31043076", "http://en.wikipedia.org/wiki/Megakaryocyte" ] + }, + "comments" : [ "Megakaryocytes are reportedly CD181-positive and CD182-positive." ], + "xrefs" : [ { + "val" : "BTO:0000843" + }, { + "val" : "CALOHA:TS-0611" + }, { + "val" : "FMA:83555" } ] } }, { @@ -1030,45 +2419,91 @@ "lbl" : "granulocyte monocyte progenitor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.", + "xrefs" : [ "GOC:amm", "GOC:dsd", "GOC:tfm", "GO_REF:0000031", "ISBN:0721601464", "MESH:D055014", "PMCID:PMC2213186", "PMCID:PMC548021", "PMID:16551251", "PMID:16647566", "http://en.wikipedia.org/wiki/CFU-GM", "http://www.copewithcytokines.de" ] + }, + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000558", "lbl" : "reticulocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds.", + "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:15946868", "PMID:2037622" ] + }, + "xrefs" : [ { + "val" : "BTO:0001173" + }, { + "val" : "CALOHA:TS-0864" + }, { + "val" : "MESH:D012156" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000559", "lbl" : "promonocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules.", + "xrefs" : [ "GOC:tfm", "ISBN:0721601464" ] + }, + "comments" : [ "Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ], + "xrefs" : [ { + "val" : "BTO:0004657" + }, { + "val" : "FMA:83551" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000562", "lbl" : "nucleate erythrocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An erythrocyte having a nucleus.", + "xrefs" : [ "GOC:add", "GOc:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000566", "lbl" : "angioblastic mesenchymal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal stem cell capable of developing into blood vessel endothelium.", + "xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ] + }, + "comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000569", "lbl" : "cardiac mesenchymal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field.", + "xrefs" : [ "PMID:18816864" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000573", "lbl" : "retinal cone cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.", + "xrefs" : [ "MESH:D017949" ] + }, + "xrefs" : [ { + "val" : "BTO:0001036" + }, { + "val" : "CALOHA:TS-0866" + }, { + "val" : "FMA:67748" } ] } }, { @@ -1076,9 +2511,16 @@ "lbl" : "corneal epithelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelial cell of the cornea.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004298" + }, { + "val" : "CALOHA:TS-0173" + }, { + "val" : "FMA:70551" } ] } }, { @@ -1086,9 +2528,17 @@ "lbl" : "monocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.", + "xrefs" : [ "GO_REF:0000031", "MESH:D009000" ] + }, + "comments" : [ "Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid." ], + "xrefs" : [ { + "val" : "BTO:0000876" + }, { + "val" : "CALOHA:TS-0638" + }, { + "val" : "FMA:62864" } ] } }, { @@ -1096,83 +2546,244 @@ "lbl" : "alveolar macrophage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative.", + "xrefs" : [ "GOC:ana", "GOC:dsd", "GOC:tfm", "GO_REF:0000031", "MESH:D016676" ] + }, + "comments" : [ "A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8.", "Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-." ], + "xrefs" : [ { + "val" : "BTO:0000802" + }, { + "val" : "CALOHA:TS-0030" + }, { + "val" : "FMA:83023" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000586", "lbl" : "germ cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The reproductive cell in multicellular organisms.", + "xrefs" : [ "MESH:D005854" ] + }, + "xrefs" : [ { + "val" : "BTO:0000535" + }, { + "val" : "NCIT:C12597" + }, { + "val" : "VHOG:0001534" + }, { + "val" : "WBbt:0006796" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000593", "lbl" : "androgen secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A steroid hormone secreting cell that secretes androgen.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000604", "lbl" : "retinal rod cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision.", + "xrefs" : [ "MESH:D017948" ] + }, + "xrefs" : [ { + "val" : "BTO:0001024" + }, { + "val" : "CALOHA:TS-0870" + }, { + "val" : "FMA:67747" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000622", + "lbl" : "acinar cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus).", + "xrefs" : [ "GOC:tfm", "http://www.copewithcytokines.de" ] + }, + "xrefs" : [ { + "val" : "FMA:83625" + }, { + "val" : "MESH:D061354" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000630", "lbl" : "supporting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell whose primary function is to support other cell types.", + "xrefs" : [ "FB:ma", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0002315" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0000666", + "lbl" : "fenestrated endothelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues.", + "xrefs" : [ "DOI:10.1007/978-3-211-99390-3_133" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000667", "lbl" : "collagen secreting cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An extracellular matrix secreting cell that secretes collagen.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000669", "lbl" : "pericyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells.", + "xrefs" : [ "GOC:dsd", "GOC:tfm", "ISBN:0721662544", "MESH:D020286", "PMID:16807374", "PMID:17986482", "PMID:20024907" ] + }, + "comments" : [ "Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A." ], + "xrefs" : [ { + "val" : "BTO:0002441" + }, { + "val" : "FMA:63174" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000670", "lbl" : "primordial germ cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells.", + "xrefs" : [ "GOC:tfm", "PMID:1381289" ] + }, + "xrefs" : [ { + "val" : "FMA:70567" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000675", "lbl" : "female gamete", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mature sexual reproductive cell of the female germline.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000680", "lbl" : "muscle precursor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A non-terminally differentiated cell that is capable of developing into a muscle cell.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000696", "lbl" : "PP cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that stores and secretes pancreatic polypeptide hormone.", + "xrefs" : [ "GOC:tfm", "JB:jb", "PMID:15153415" ] + }, + "xrefs" : [ { + "val" : "FMA:62938" + }, { + "val" : "FMA:83409" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000710", "lbl" : "neurecto-epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial cells derived from neural plate and neural crest.", + "xrefs" : [ "GOC:tfm" ] + }, + "comments" : [ "The term \"neuroepithelial cell\" is used to describe both this cell type and sensory epithelial cell (CL:0000098)." ], + "xrefs" : [ { + "val" : "BTO:0004301" + }, { + "val" : "FMA:70557" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000723", "lbl" : "somatic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that can give rise to cell types of the body other than those of the germ-line.", + "xrefs" : [ "GO:0048103" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2086" + }, { + "val" : "MESH:D053687" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000737", "lbl" : "striated muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle cell which has as its direct parts myofilaments organized into sarcomeres.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "BTO:0002916" + }, { + "val" : "CALOHA:TS-2157" + }, { + "val" : "FMA:86936" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000738", "lbl" : "leukocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.", + "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:978-0-323-05290-0" ] + }, + "xrefs" : [ { + "val" : "BTO:0000751" + }, { + "val" : "CALOHA:TS-0549" + }, { + "val" : "FMA:62852" + }, { + "val" : "MESH:D007962" + }, { + "val" : "NCIT:C12529" } ] } }, { @@ -1180,9 +2791,16 @@ "lbl" : "retinal ganglion cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.", + "xrefs" : [ "GOC:dph" ] + }, + "xrefs" : [ { + "val" : "BTO:0001800" + }, { + "val" : "FMA:67765" + }, { + "val" : "MESH:D012165" } ] } }, { @@ -1190,327 +2808,804 @@ "lbl" : "cardiac muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.", + "xrefs" : [ "GOC:mtg_cardiacconduct_nov11", "GOC:tfm", "ISBN:0323052908", "PMID:22426062", "PMID:4711263" ] + }, + "comments" : [ "This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction." ], + "xrefs" : [ { + "val" : "BTO:0001539" + }, { + "val" : "CALOHA:TS-0115" + }, { + "val" : "FMA:14067" + }, { + "val" : "MESH:D032383" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000763", "lbl" : "myeloid cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.", + "xrefs" : [ "GOC:add" ] + }, + "xrefs" : [ { + "val" : "BTO:0001441" + }, { + "val" : "CALOHA:TS-0647" + }, { + "val" : "MESH:D022423" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000764", "lbl" : "erythroid lineage cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A immature or mature cell in the lineage leading to and including erythrocytes.", + "xrefs" : [ "GOC:add", "GOC:tfm" ] + }, + "comments" : [ "Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes." ], + "xrefs" : [ { + "val" : "CALOHA:TS-0290" + }, { + "val" : "FMA:62845" + }, { + "val" : "FMA:83516" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000765", "lbl" : "erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.", + "xrefs" : [ "GOC:add", "ISBN:0721601464", "PMID:18174176" ] + }, + "xrefs" : [ { + "val" : "BTO:0001571" + }, { + "val" : "CALOHA:TS-0289" + }, { + "val" : "FMA:83504" + }, { + "val" : "MESH:D004900" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000766", "lbl" : "myeloid leukocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the monocyte, granulocyte, or mast cell lineage.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000778", "lbl" : "mononuclear osteoclast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts.", + "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:12713016", "PMID:15055519", "PMID:17380158", "PMID:9415452" ] + }, + "comments" : [ "Morphology: mononuclear, highly vesicular." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000779", "lbl" : "multinuclear osteoclast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized multinuclear osteoclast associated with the absorption and removal of bone.", + "xrefs" : [ "GOC:add", "PMID:12713016", "PMID:9415452" ] + }, + "comments" : [ "Morphology: multinucleated, highly vesicular." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000782", "lbl" : "myeloid dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dendritic cell of the myeloid lineage.", + "xrefs" : [ "GOC:add", "PMID:10449155", "PMID:17332250", "PMID:9521319" ] + }, + "comments" : [ "These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8)." ], + "xrefs" : [ { + "val" : "BTO:0004721" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000783", "lbl" : "multinucleated phagocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A phagocyte formed by the fusion of mononuclear phagocytes.", + "xrefs" : [ "GOC:add", "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000827", "lbl" : "pro-T cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000835", "lbl" : "myeloblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow.", + "xrefs" : [ "GOC:add", "ISBN:0721601464", "http://en.wikipedia.org/wiki/Myeloblast", "http://www.cap.org" ] + }, + "xrefs" : [ { + "val" : "BTO:0000187" + }, { + "val" : "FMA:83524" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000837", "lbl" : "hematopoietic multipotent progenitor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans.", + "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:19022770" ] + }, + "comments" : [ "Markers differ between mouse and human." ], + "xrefs" : [ { + "val" : "BTO:0000725" + }, { + "val" : "CALOHA:TS-0448" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000838", "lbl" : "lymphoid lineage restricted progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell restricted to the lymphoid lineage.", + "xrefs" : [ "GOC:add", "GOC:tfm" ] + }, + "comments" : [ "Note that this is a class of cell types, not an identified single cell type." ], + "xrefs" : [ { + "val" : "BTO:0004731" + }, { + "val" : "CALOHA:TS-2025" + }, { + "val" : "FMA:70338" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000839", "lbl" : "myeloid lineage restricted progenitor cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A progenitor cell restricted to the myeloid lineage.", + "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:19022770" ] + }, + "comments" : [ "Note that this is a class of cell types, not an identified single cell type." ], + "xrefs" : [ { + "val" : "BTO:0004730" + }, { + "val" : "CALOHA:TS-2099" + }, { + "val" : "FMA:70339" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000842", "lbl" : "mononuclear cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A leukocyte with a single non-segmented nucleus in the mature form.", + "xrefs" : [ "GOC:add" ] + }, + "xrefs" : [ { + "val" : "BTO:0000878" + }, { + "val" : "CALOHA:TS-0768" + }, { + "val" : "FMA:86713" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000860", "lbl" : "classical monocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes.", + "xrefs" : [ "GOC:add", "GO_REF:0000031", "PMID:16322748", "PMID:18303997", "PMID:20628149", "PMID:20870168" ] + }, + "comments" : [ "Markers: CCR2+CXCCR1 (human, mouse, rat)." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000861", "lbl" : "elicited macrophage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive.", + "xrefs" : [ "GOC:add", "GOC:ana", "GOC:tfm", "GO_REF:0000031", "PMID:15771589" ] + }, + "comments" : [ "Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response)." ], + "xrefs" : [ { + "val" : "FMA:84643" + }, { + "val" : "FMA:84645" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000862", "lbl" : "suppressor macrophage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macrophage that suppresses immune responses.", + "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:20402419" ] + }, + "comments" : [ "Markers: May express: IL10, TGFbeta." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000864", "lbl" : "tissue-resident macrophage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.", + "xrefs" : [ "GOC:ana", "GO_REF:0000031", "PMID:19770654" ] + }, + "xrefs" : [ { + "val" : "FMA:84642" + }, { + "val" : "FMA:84644" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000878", "lbl" : "central nervous system macrophage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tissue-resident macrophage found in the central nervous system.", + "xrefs" : [ "GO_REF:0000031", "PMID:16322748" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000936", "lbl" : "early lymphoid progenitor", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative.", + "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19022770" ] + }, + "comments" : [ "Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000988", "lbl" : "hematopoietic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of a hematopoietic lineage.", + "xrefs" : [ "GOC:add", "GO_REF:0000031" ] + }, + "xrefs" : [ { + "val" : "BTO:0000574" + }, { + "val" : "CALOHA:TS-2017" + }, { + "val" : "FMA:70366" + }, { + "val" : "FMA:83598" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000990", "lbl" : "conventional dendritic cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Conventional dendritic cell is a dendritic cell that is CD11c-high.", + "xrefs" : [ "GOC:amm", "GO_REF:0000031", "PMID:17850486" ] + }, + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive." ], + "xrefs" : [ { + "val" : "FMA:84191" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0000995", "lbl" : "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001008", "lbl" : "Kit and Sca1-positive hematopoietic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative.", + "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17952047", "PMID:19022770" ] + }, + "comments" : [ "Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001012", "lbl" : "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001019", "lbl" : "CD115-positive monocyte OR common dendritic progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001021", "lbl" : "CD34-positive, CD38-positive common lymphoid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive.", + "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585", "PMID:19022770" ] + }, + "comments" : [ "These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001022", "lbl" : "CD115-positive monocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive.", + "xrefs" : [ "GOC:add", "GOC:amm", "GO_REF:0000031", "PMID:17952047" ] + }, + "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001023", "lbl" : "Kit-positive, CD34-positive common myeloid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low.", + "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:1261582", "PMID:17952047", "http://www.immgen.org/index_content.html" ] + }, + "comments" : [ "Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001024", "lbl" : "CD34-positive, CD38-negative hematopoietic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive.", + "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:10430905", "PMID:11750107", "PMID:16551251", "PMID:20024907", "PMID:9389721" ] + }, + "comments" : [ "Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617)." ], + "xrefs" : [ { + "val" : "CALOHA:TS-0448" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001025", "lbl" : "Kit-positive, Sca1-positive common lymphoid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low.", + "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17952047", "http://www.immgen.org/index_content.html" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001026", "lbl" : "CD34-positive, CD38-positive common myeloid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative.", + "xrefs" : [ "GOC:add", "GOC:amm", "GO_REF:0000031", "PMCID:PMC2626675", "PMID:16551251" ] + }, + "comments" : [ "Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001027", "lbl" : "CD7-negative lymphoid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative.", + "xrefs" : [ "GOC:amm", "GO_REF:0000031", "PMID:16551251" ] + }, + "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001028", "lbl" : "CD7-positive lymphoid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative.", + "xrefs" : [ "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:19491395" ] + }, + "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001029", "lbl" : "common dendritic progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers.", + "xrefs" : [ "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:17922016", "PMID:19286519" ] + }, + "comments" : [ "Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001030", "lbl" : "CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001035", "lbl" : "bone cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A connective tissue cell found in bone.", + "xrefs" : [ "GOC:add", "GO_REF:0000034" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001054", "lbl" : "CD14-positive monocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20.", + "xrefs" : [ "GOC:add", "PMID:22343568" ] + }, + "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001059", "lbl" : "common myeloid progenitor, CD34-positive", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1.", + "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0878932437", "PMCID:PMC2212039", "PMID:10724173", "PMID:16551251", "PMID:16647566" ] + }, + "comments" : [ "CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001060", "lbl" : "hematopoietic oligopotent progenitor cell, lineage-negative", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers.", + "xrefs" : [ "GOC:tfm", "PMID:19022770" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0001066", "lbl" : "erythroid progenitor cell, mammalian", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative).", + "xrefs" : [ "GOC:add", "ISBN:0721601464" ] + }, + "xrefs" : [ { + "val" : "BTO:0004911" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002000", "lbl" : "Kit-positive erythroid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084", "http://www.immgen.org/index_content.html" ] + }, + "comments" : [ "Markers found on mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002001", "lbl" : "CD34-positive, CD38-positive granulocyte monocyte progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative.", + "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:19022770" ] + }, + "comments" : [ "Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002002", "lbl" : "Kit-positive granulocyte monocyte progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative.", + "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:16322423", "PMID:19022770", "PMID:19273628", "http://www.immgen.org/index_content.html" ] + }, + "comments" : [ "Markers are found on mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002003", "lbl" : "CD34-positive, GlyA-negative erythroid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An erythroid progenitor cell that is CD34-positive and is GlyA-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19621348" ] + }, + "comments" : [ "Cell markers associated with human cells." ], + "xrefs" : [ { + "val" : "FMA:83517" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002004", "lbl" : "CD34-negative, GlyA-negative proerythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A proerythoblast that is CD34-negative and GlyA-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19621348" ] + }, + "comments" : [ "Cell surface markers are associated with human cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002005", "lbl" : "CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative.", + "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:190227700" ] + }, + "comments" : [ "Markers are associated with human cell type." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002006", "lbl" : "Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low.", + "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:19022770", "http://www.immgen.org/index_content.html" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002009", "lbl" : "macrophage dendritic cell progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages.", + "xrefs" : [ "GOC:tfm", "PMID:19273628" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002010", "lbl" : "pre-conventional dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002011", "lbl" : "Kit-positive macrophage dendritic cell progenitor", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative.", + "xrefs" : [ "GOC:tfm", "PMID:19273628" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002012", "lbl" : "Kit-low proerythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002013", "lbl" : "GlyA-positive basophilic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A basophilic erythroblast that is GlyA-positive.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:1638021" ] + }, + "comments" : [ "Markers are associated with human cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002014", "lbl" : "Kit-negative, Ly-76 high basophilic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A basophilic erythroblast that is Lyg 76-high and is Kit-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] + }, + "comments" : [ "Cell surface markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002015", "lbl" : "Kit-negative, Ly-76 high polychromatophilic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002016", "lbl" : "CD71-low, GlyA-positive polychromatic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A polychromatiic erythroblast that is Gly-A-positive and CD71-low.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:1638021" ] + }, + "comments" : [ "Cell surface markers are associated with human cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002017", "lbl" : "Kit-negative, Ly-76 high orthochromatophilic erythroblasts", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ] + }, + "comments" : [ "Cell surface markers associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002018", "lbl" : "CD71-negative, GlyA-positive orthochromatic erythroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An erythroblast that is GlyA-positive and CD71-negative.", + "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:1638021" ] + }, + "comments" : [ "Markers associated with human cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002031", "lbl" : "hematopoietic lineage restricted progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells.", + "xrefs" : [ "GOC:tfm", "PMID:19022770" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002032", "lbl" : "hematopoietic oligopotent progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities.", + "xrefs" : [ "GOC:tfm", "PMID:19022770", "https://orcid.org/0000-0001-5208-3432" ] + }, + "comments" : [ "This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002033", "lbl" : "short term hematopoietic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative.", + "xrefs" : [ "GOC:tfm", "PMID:15572596", "PMID:19022770" ] + }, + "comments" : [ "Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002034", "lbl" : "long term hematopoietic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative.", + "xrefs" : [ "GOC:tfm", "PMID:15572596", "PMID:17582345" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002035", "lbl" : "Slamf1-negative multipotent progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative.", + "xrefs" : [ "GOC:tfm", "PMID:19022770" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002036", "lbl" : "Slamf1-positive multipotent progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive.", + "xrefs" : [ "GOC:tfm", "PMID:19022770" ] + }, + "comments" : [ "Markers are associated with mouse cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002043", "lbl" : "CD34-positive, CD38-negative multipotent progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative.", + "xrefs" : [ "GOC:tfm", "PMID:18371405", "PMID:19022770" ] + }, + "comments" : [ "Cell markers are associated with human hematopoietic multipotent progenitor cells." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002062", "lbl" : "pulmonary alveolar type 1 cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange.", + "xrefs" : [ "GOC:tfm", "PMID:20054144", "PMID:29463737", "http://www.copewithcytokines.de" ] + }, + "xrefs" : [ { + "val" : "BTO:0000780" + }, { + "val" : "FMA:62500" } ] } }, { @@ -1518,87 +3613,286 @@ "lbl" : "pulmonary alveolar type 2 cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli.", + "xrefs" : [ "GOC:tfm", "ISBN:0412046911", "PMID:36138472", "PMID:8540632", "http://www.copewithcytokines.de" ] + }, + "xrefs" : [ { + "val" : "BTO:0000538" + }, { + "val" : "FMA:62501" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002064", + "lbl" : "pancreatic acinar cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "PMID:20395539", "http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells" ] + }, + "xrefs" : [ { + "val" : "BTO:0000028" + }, { + "val" : "CALOHA:TS-0737" + }, { + "val" : "FMA:63032" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002067", "lbl" : "type A enteroendocrine cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An enteroendocrine cell that produces glucagon.", + "xrefs" : [ "GOC:tfm", "ISBN:0412046911" ] + }, + "xrefs" : [ { + "val" : "FMA:62939" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002068", "lbl" : "Purkinje myocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter.", + "xrefs" : [ "FMA:0412046911", "GOC:tfm", "PMID:19939742" ] + }, + "xrefs" : [ { + "val" : "BTO:0001032" + }, { + "val" : "FMA:14146" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002072", "lbl" : "nodal myocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery.", + "xrefs" : [ "FMA:67101", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004190" + }, { + "val" : "FMA:67101" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002073", "lbl" : "transitional myocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes.", + "xrefs" : [ "FMA:67142", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67142" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002074", "lbl" : "myocardial endocrine cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides).", + "xrefs" : [ "FMA:67111", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67111" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002076", "lbl" : "endo-epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell derived from endoderm.", + "xrefs" : [ "FMA:69075", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:69075" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002077", "lbl" : "ecto-epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell derived from ectoderm.", + "xrefs" : [ "FMA:69074", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:69074" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002078", "lbl" : "meso-epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial cell derived from mesoderm or mesenchyme.", + "xrefs" : [ "FMA:69076", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:69076" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002079", + "lbl" : "pancreatic ductal cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH.", + "xrefs" : [ "FMA:63099", "GOC:tfm", "PMID:14740223" ] + }, + "xrefs" : [ { + "val" : "FMA:63099" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002080", + "lbl" : "pancreatic centro-acinar cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types.", + "xrefs" : [ "GOC:tfm", "PMID:12142741", "PMID:20018761", "PMID:8185160" ] + }, + "xrefs" : [ { + "val" : "FMA:62455" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002086", "lbl" : "specialized cardiac myocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart.", + "xrefs" : [ "FMA:67968", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67968" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002087", "lbl" : "nongranular leukocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A leukocyte that lacks granules.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:62855" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002088", + "lbl" : "interstitial cell of Cajal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise.", + "xrefs" : [ "GOC:tfm", "PMID:16460275", "PMID:19520112" ] + }, + "comments" : [ "Some argue this cell type is of mesenchymal origin." ], + "xrefs" : [ { + "val" : "BTO:0003914" + }, { + "val" : "FMA:86573" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002092", "lbl" : "bone marrow cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells.", + "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ] + }, + "comments" : [ "MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense." ], + "xrefs" : [ { + "val" : "BTO:0004850" + }, { + "val" : "FMA:83621" + }, { + "val" : "MESH:D001854" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002095", "lbl" : "hilus cell of ovary", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell in the hilum of the ovary that produces androgens.", + "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ] + }, + "xrefs" : [ { + "val" : "FMA:18710" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002132", "lbl" : "stromal cell of ovary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stomal cell of the ovary", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:72299" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002139", "lbl" : "endothelial cell of vascular tree", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.", + "xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ] + }, + "comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive." ], + "xrefs" : [ { + "val" : "BTO:0001854" + }, { + "val" : "CALOHA:TS-1106" + }, { + "val" : "FMA:67755" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002144", "lbl" : "capillary endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell found in capillaries.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004956" + }, { + "val" : "CALOHA:TS-0112" + }, { + "val" : "FMA:67756" } ] } }, { @@ -1606,415 +3900,1203 @@ "lbl" : "ciliated columnar cell of tracheobronchial tree", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ] + }, + "xrefs" : [ { + "val" : "FMA:70542" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002159", "lbl" : "general ecto-epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial cells derived from general body ectoderm and ectoderm placodes.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70556" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002178", "lbl" : "epithelial cell of stomach", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell found in the lining of the stomach.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:62948" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002180", "lbl" : "mucous cell of stomach", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucous cell in the epithelium of the stomach.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:63464" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002183", "lbl" : "stem cell of gastric gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ] + }, + "xrefs" : [ { + "val" : "FMA:62953" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002191", "lbl" : "granulocytopoietic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell involved in the formation of a granulocyte.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83519" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002194", "lbl" : "monopoietic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell involved in the formation of a monocyte (monopoiesis).", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83552" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002195", + "lbl" : "hepatic stem cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes).", + "xrefs" : [ "GOC:tfm", "PMID:26798363" ] + }, + "xrefs" : [ { + "val" : "FMA:86577" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002202", "lbl" : "epithelial cell of tracheobronchial tree", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the tracheobronchial tree.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:66816" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002209", "lbl" : "intermediate epitheliocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells.", + "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ] + }, + "xrefs" : [ { + "val" : "FMA:69060" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002222", "lbl" : "vertebrate lens cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "FMA:70950" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002224", "lbl" : "lens epithelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544", "http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium" ] + }, + "xrefs" : [ { + "val" : "FMA:67559" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002240", "lbl" : "marrow fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast in the bone marrow.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:84377" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002241", "lbl" : "pulmonary interstitial fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:84467" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002242", "lbl" : "nucleate cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell containing at least one nucleus.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67513" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002243", + "lbl" : "smooth muscle cell of sphincter of pupil", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544", "ISBN:0721694128" ] + }, + "xrefs" : [ { + "val" : "FMA:70611" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002246", "lbl" : "peripheral blood stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells).", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0002669" + }, { + "val" : "FMA:86711" + }, { + "val" : "MESH:D000072916" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002251", "lbl" : "epithelial cell of alimentary canal", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus.", + "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002252", "lbl" : "epithelial cell of esophagus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the esophagus.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:63071" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002253", + "lbl" : "epithelial cell of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the large intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004297" + }, { + "val" : "FMA:256157" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002254", + "lbl" : "epithelial cell of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the small intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:256159" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002262", "lbl" : "endothelial cell of sinusoid", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver.", + "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ] + }, + "xrefs" : [ { + "val" : "FMA:63134" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002264", "lbl" : "type A cell of stomach", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A type of enteroendocrine cell found in the stomach that secretes glucagon.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83411" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002265", + "lbl" : "type D cell of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A D cell located in the colon.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:268744" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002266", + "lbl" : "type D cell of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A type D cell of the small intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:268736" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002267", + "lbl" : "type D cell of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A type D cell found in the stomach.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83410" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002275", + "lbl" : "pancreatic PP cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A PP cell located in the islets of the pancreas.", + "xrefs" : [ "GOC:tfm" ] + }, + "comments" : [ "The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell." ], + "xrefs" : [ { + "val" : "BTO:0000805" + }, { + "val" : "FMA:70588" + }, { + "val" : "MESH:D050418" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002308", "lbl" : "epithelial cell of skin gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of a skin gland.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70657" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002319", "lbl" : "neural cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that is part of the nervous system.", + "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2040" + }, { + "val" : "FMA:70333" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002320", "lbl" : "connective tissue cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.", + "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2096" + }, { + "val" : "FMA:63875" + }, { + "val" : "MESH:D003239" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002321", "lbl" : "embryonic cell (metazoa)", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the embryo.", + "xrefs" : [ "FMA:0618947256" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0263" + }, { + "val" : "FMA:82840" + }, { + "val" : "WBbt:0007028" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002328", "lbl" : "bronchial epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the bronchus.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0002922" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002332", "lbl" : "ciliated cell of the bronchus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A ciliated cell of the bronchus.", + "xrefs" : [ "GOC:tfm", "PMID:18757316" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002333", "lbl" : "neural crest derived adipocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipocyte derived from a neural crest cell.", + "xrefs" : [ "GOC:tfm", "PMID:17507398" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002350", "lbl" : "endocardial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin.", + "xrefs" : [ "GOC:tfm", "ISSN:0452-3458" ] + }, + "xrefs" : [ { + "val" : "FMA:75621" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002351", + "lbl" : "progenitor cell of endocrine pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1.", + "xrefs" : [ "GOC:tfm", "PMID:20025937", "PMID:20217494", "PMID:22728667" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002352", "lbl" : "gestational hematopoietic stem cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hematopoietic stem cell that exists during embryogenesis.", + "xrefs" : [ "GOC:tfm", "ISBN:978-60327-246-6" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002363", "lbl" : "keratocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate.", + "xrefs" : [ "GOC:tfm", "ISBN:9780702029585" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002368", "lbl" : "respiratory epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endo-epithelial cell of the respiratory tract.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004533" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002372", "lbl" : "myotube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts.", + "xrefs" : [ "GOC:dos", "GOC:tfm", "ISBN:0323052908", "PMID:22274696" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002397", "lbl" : "CD14-positive, CD16-positive monocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A CD14-positive monocyte that is also CD16-positive and CCR2-negative.", + "xrefs" : [ "GOC:tfm", "PMID:20628149", "PMID:21937707", "PMID:22343568" ] + }, + "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002421", "lbl" : "nucleated reticulocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles.", + "xrefs" : [ "GOC:tfm", "PMID:18182572", "PMID:9011180", "PMID:9046052" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002454", "lbl" : "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive.", + "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002462", "lbl" : "adipose dendritic cell", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/CL_0002463", - "lbl" : "SIRPa-positive adipose dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A F4/80-negative dendritic cell located in adipose tissue.", + "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002463", + "lbl" : "SIRPa-positive adipose dendritic cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipose dendritic cell that is SIRPa-positive.", + "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002464", "lbl" : "SIRPa-negative adipose dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipose dendritic cell that is SIRPa-negative.", + "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002465", "lbl" : "CD11b-positive dendritic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A conventional dendritic cell that expresses CD11b (ITGAM).", + "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002494", "lbl" : "cardiocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell located in the heart, including both muscle and non muscle cells.", + "xrefs" : [ "GOC:tfm" ] + }, + "comments" : [ "From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart." ], + "xrefs" : [ { + "val" : "BTO:0001539" + }, { + "val" : "CALOHA:TS-0115" + }, { + "val" : "FMA:83808" + }, { + "val" : "FMA:84791" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002503", "lbl" : "adventitial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0002441" + }, { + "val" : "FMA:84639" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002504", + "lbl" : "enteric smooth muscle cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the intestine.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002521", "lbl" : "subcutaneous adipocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An adipocyte that is part of subcutaneous adipose tissue.", + "xrefs" : [ "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002538", + "lbl" : "intrahepatic cholangiocyte", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes.", + "xrefs" : [ "GOC:tfm", "PMID:23720296" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002539", "lbl" : "aortic smooth muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the aorta.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004577" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002540", "lbl" : "mesenchymal stem cell of the bone marrow", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal stem cell that is part of the bone marrow.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002543", "lbl" : "vein endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell that is part of the vein.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:62104" + }, { + "val" : "KUPO:0001099" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002546", "lbl" : "embryonic blood vessel endothelial progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial progenitor cell that participates in angiogenesis during development.", + "xrefs" : [ "GOC:tfm" ] + }, + "comments" : [ "See CL:0002619." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002547", "lbl" : "fibroblast of the aortic adventitia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast of the aortic adventitia.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002548", "lbl" : "fibroblast of cardiac tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast that is part of the heart.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002551", "lbl" : "fibroblast of dermis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any skin fibroblast that is part of some dermis.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002553", "lbl" : "fibroblast of lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast that is part of lung.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0000764" + }, { + "val" : "CALOHA:TS-0575" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002557", "lbl" : "fibroblast of pulmonary artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A fibroblast of pulmonary artery.", + "xrefs" : [ "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002563", + "lbl" : "intestinal epithelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the intestine.", + "xrefs" : [ "GOC:tfm" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002570", "lbl" : "mesenchymal stem cell of adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal stem cell of adipose tissue.", + "xrefs" : [ "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002571", + "lbl" : "hepatic mesenchymal stem cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal stem cell of liver.", + "xrefs" : [ "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002572", + "lbl" : "vertebral mesenchymal stem cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal stem cell of the vertebrae.", + "xrefs" : [ "GOC:tfm" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002574", + "lbl" : "stromal cell of pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stromal cell of the pancreas.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002575", "lbl" : "central nervous system pericyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pericyte of the central nervous system.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002585", "lbl" : "retinal blood vessel endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A blood vessel endothelial cell that is part of the retina.", + "xrefs" : [ "GOC:tfm" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002589", "lbl" : "smooth muscle cell of the brachiocephalic vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the bachiocephalic vasculature.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002590", "lbl" : "smooth muscle cell of the brain vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vascular associated smooth muscle cell of the brain vasculature.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002591", "lbl" : "smooth muscle cell of the pulmonary artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A smooth muscle of the pulmonary artery.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0003336" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002595", "lbl" : "smooth muscle cell of the subclavian artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the subclavian artery.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002596", "lbl" : "smooth muscle cell of the carotid artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Smooth muscle cell of the carotid artery.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002598", "lbl" : "bronchial smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Any smooth muscle cell that is part of some bronchus.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "BTO:0004402" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002599", "lbl" : "smooth muscle cell of the esophagus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the esophagus.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002600", "lbl" : "smooth muscle cell of trachea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell of the trachea.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002610", "lbl" : "raphe nuclei neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron of the raphe nuclei.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002612", "lbl" : "neuron of the ventral spinal cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron of the ventral spinal cord.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002620", "lbl" : "skin fibroblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A fibroblast of skin.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0001255" + }, { + "val" : "CALOHA:TS-0935" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002632", "lbl" : "epithelial cell of lower respiratory tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any epithelial cell that is part of some lower respiratory tract epithelium.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002653", "lbl" : "squamous endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A squamous shaped endothelial cell.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002657", "lbl" : "glandular cell of esophagus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A glandular epithelial cell of the esophagus.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:86548" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002658", + "lbl" : "glandular cell of the large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A glandular epithelial cell of the large intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:87194" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002659", "lbl" : "glandular cell of stomach", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A glandular epithelial cell that is part of the stomach.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1284" + }, { + "val" : "FMA:86554" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002663", "lbl" : "myocardial endocrine cell of atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myocardial endocrine cell that is part of the atrium.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83389" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002664", "lbl" : "cardioblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart.", + "xrefs" : [ "GOC:tfm", "PMID:19745164" ] + }, + "comments" : [ "Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002672", "lbl" : "retinal progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells.", + "xrefs" : [ "GOC:tfm", "PMID:20959166", "PMID:21148186" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0002676", "lbl" : "neural crest derived neuroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuroblast derived from a neural crest cell.", + "xrefs" : [ "GOC:tfm", "PMID:17407019" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0002680", + "lbl" : "PP cell of intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A PP cell found in intestine.", + "xrefs" : [ "GOC:tfm", "PMID:2420136", "PMID:728970" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0005000", "lbl" : "spinal cord interneuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A CNS interneuron located in the spinal cord.", + "xrefs" : [ "CL:CVS" ] + }, + "comments" : [ "Is_a interneuron, part_of UBERON:0002240." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0005012", "lbl" : "multi-ciliated epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ciliated epithelial cell with many cilia.", + "xrefs" : [ "CL:CVS" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0005026", + "lbl" : "hepatoblast", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation.", + "xrefs" : [ "GOC:CVS", "PMID:18356246", "PMID:20483998", "PMID:26798363", "https://orcid.org/0000-0003-1940-6740" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0007001", "lbl" : "skeletogenic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized).", + "xrefs" : [ "GO_REF:0000034" ] + }, + "comments" : [ "Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0007004", "lbl" : "premigratory neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells.", + "xrefs" : [ "UBERONREF:0000002" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0007009", "lbl" : "prechondroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells.", + "xrefs" : [ "GO_REF:0000034" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008000", "lbl" : "non-striated muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle cell in which the fibers are not organised into sarcomeres.", + "xrefs" : [ "GOC:DOS" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008001", "lbl" : "hematopoietic precursor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any hematopoietic cell that is a precursor of some other hematopoietic cell type.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008002", "lbl" : "skeletal muscle fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:tfm", "ISBN:0323052908" ] + }, + "xrefs" : [ { + "val" : "MESH:D018485" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008007", "lbl" : "visceral muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle cell that is part of some visceral muscle.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008008", "lbl" : "striated visceral muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008009", "lbl" : "transversely striated visceral muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008017", "lbl" : "adult skeletal muscle myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers.", + "xrefs" : [ "PMID:23303905" ] + }, + "comments" : [ "The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008019", "lbl" : "mesenchymal cell", @@ -2022,38 +5104,68 @@ "meta" : { "definition" : { "val" : "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008022", "lbl" : "endocardial cushion cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves.", + "xrefs" : [ "PMID:18816864" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0008024", + "lbl" : "pancreatic endocrine cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endocrine cell that is part of the pancreas.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008028", "lbl" : "visual system neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neuron that is capable of part of some visual perception.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008034", "lbl" : "mural cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation.", + "xrefs" : [ "Wiki:Mural_cell&oldid=930603194" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0008035", "lbl" : "microcirculation associated smooth muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009000", "lbl" : "sensory neuron of spinal nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord.", + "xrefs" : [ "GOC:nv", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009001", "lbl" : "compound eye retinal cell", @@ -2061,26 +5173,227 @@ "meta" : { "definition" : { "val" : "Any cell in the compound eye, a light sensing organ composed of ommatidia." - } + }, + "xrefs" : [ { + "val" : "GOC:pr" + }, { + "val" : "PMID:12021768" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009004", "lbl" : "retinal cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.", + "xrefs" : [ "GOC:pr" ] + }, + "xrefs" : [ { + "val" : "PMID:10702418" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009006", + "lbl" : "enteroendocrine cell of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An enteroendocrine cell that is located in the small intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009018", + "lbl" : "lymphocyte of large intestine lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lymphocyte that resides in the lamina propria of the large intestine.", + "xrefs" : [ "https://orcid.org/0000-0003-4183-8865" ] + }, + "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009021", + "lbl" : "stromal cell of lamina propria of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stromal cell found in the lamina propria of the large intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009022", + "lbl" : "stromal cell of lamina propria of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stromal cell found in the lamina propria of the small intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009024", + "lbl" : "mesothelial cell of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the small intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009025", + "lbl" : "mesothelial cell of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009038", + "lbl" : "colon macrophage", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macrophage that is located in the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + }, + "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009040", + "lbl" : "stromal cell of lamina propria of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stromal cell found in the lamina propria of the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009042", + "lbl" : "enteroendocrine cell of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An enteroendocrine cell that is located in the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009044", + "lbl" : "lymphocyte of small intestine lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response.", + "xrefs" : [ "PMID:26551552", "https://orcid.org/0000-0003-4183-8865" ] + }, + "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009048", + "lbl" : "anorectum macrophage", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macrophage that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + }, + "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009051", + "lbl" : "T cell of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A T cell that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + }, + "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009052", + "lbl" : "smooth muscle cell of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009053", + "lbl" : "stromal cell of anorectum lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stromal cell found in the lamina propria of the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009063", + "lbl" : "enteroendocrine cell of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An enteroendocrine cell that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009089", "lbl" : "lung pericyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A pericyte cell that is part of a lung.", + "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ] + }, + "xrefs" : [ { + "val" : "EFO:0010669" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009094", + "lbl" : "endothelial cell of hepatic portal vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell that is part of a hepatic portal vein.", + "xrefs" : [ "PMID:30348985", "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ] + }, + "xrefs" : [ { + "val" : "EFO:0010704" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0009097", "lbl" : "embryonic skeletal muscle fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development.", + "xrefs" : [ "PMID:32094117", "PMID:7196501", "http://orcid.org/0000-0003-2034-601X" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0009100", + "lbl" : "hepatic portal fibroblast", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen.", + "xrefs" : [ "PMID:20209607", "PMID:24814904", "https://orcid.org/0000-0001-7655-4833" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010001", "lbl" : "stromal cell of bone marrow", @@ -2097,7 +5410,11 @@ "meta" : { "definition" : { "val" : "An epithelial cell that is part_of a alveolus of lung." - } + }, + "comments" : [ "May be merged with pneumocyte in future" ], + "xrefs" : [ { + "val" : "MESH:D056809" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010004", @@ -2111,25 +5428,43 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0010006", "lbl" : "cardiac blood vessel endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any blood vessel endothelial cell that is part of some heart.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010007", "lbl" : "His-Purkinje system cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that is part of some His-Purkinje system.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010008", "lbl" : "cardiac endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any endothelial cell that is part of some heart.", + "xrefs" : [ "FBC:Autogenerated" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010009", "lbl" : "camera-type eye photoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any photoreceptor cell that is part of some camera-type eye.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010017", "lbl" : "zygote", @@ -2137,32 +5472,75 @@ "meta" : { "definition" : { "val" : "A zygote in a plant or an animal." - } + }, + "xrefs" : [ { + "val" : "MESH:D015053" + } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010020", "lbl" : "cardiac glial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any glial cell that is part of some heart.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010021", "lbl" : "cardiac myoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any myoblast that develops into some cardiac muscle cell.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "MESH:D032386" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0010022", "lbl" : "cardiac neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron that has its soma in the heart.", + "xrefs" : [ "PMID:12486170", "PMID:29265764" ] + }, + "comments" : [ "This term is used in 3 GO terms that were created as part of the heart development focus project." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011001", "lbl" : "spinal cord motor neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.", + "xrefs" : [ "GOC:nv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011007", "lbl" : "paraxial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites.", + "xrefs" : [ "GOC:NV", "PMID:11687492" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011012", "lbl" : "neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.", + "xrefs" : [ "https://orcid.org/0000-0001-5208-3432", "https://orcid.org/0000-0002-9900-7880" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011019", "lbl" : "mesothelial cell of epicardium", @@ -2193,35 +5571,94 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_0011026", "lbl" : "progenitor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses.", + "xrefs" : [ "ISBN:978-1-62808-994-3", "https://doi.org/10.1016/B978-0-12-409503-8.00002-0" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011027", "lbl" : "skeletal muscle fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of skeletal muscle tissue.", + "xrefs" : [ "PMID:28369879", "https://orcid.org/0000-0001-6164-0667" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011030", "lbl" : "dermal microvascular endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microvascular endothelial cell that is part of the dermis.", + "xrefs" : [ "BTO:0004574", "CL:patterns/cellPartOfAnatomicalEntity" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0011108", + "lbl" : "colon epithelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial cell that is part of the colon epithelium.", + "xrefs" : [ "GOC:NV" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0011115", "lbl" : "precursor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that, by division or terminal differentiation, can give rise to other cell types.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0017500", "lbl" : "neutrophillic cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0017502", "lbl" : "acidophilic cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0017503", "lbl" : "basophilic cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0017504", "lbl" : "polychromatophilic cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions.", + "xrefs" : [ "GOC:tfm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_0019001", "lbl" : "tracheobronchial serous cell", @@ -2238,102 +5675,275 @@ "meta" : { "definition" : { "val" : "Any chondrocyte that is part of the tracheobronchial tree." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0019018", "lbl" : "blood vessel smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A smooth muscle cell that is part of any blood vessel.", + "xrefs" : [ "PMID:9108778" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_0019019", "lbl" : "tracheobronchial smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A smooth muscle cell that is part of the tracheobronchial tree.", + "xrefs" : [ "PMID:10853867" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0019020", + "lbl" : "extrahepatic cholangiocyte", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes.", + "xrefs" : [ "PMID:23720296" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0019021", + "lbl" : "endothelial cell of periportal hepatic sinusoid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid.", + "xrefs" : [ "PMID:27423426" ] + }, + "xrefs" : [ { + "val" : "EFO:0010705" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_0019022", + "lbl" : "endothelial cell of pericentral hepatic sinusoid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid.", + "xrefs" : [ "PMID:27423426" ] + }, + "xrefs" : [ { + "val" : "EFO:0010706" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000222", "lbl" : "stomach neuroendocrine cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neuroendocrine cell that is part of some stomach.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000223", "lbl" : "lung neuroendocrine cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury.", + "xrefs" : [ "PMID:33355253", "doi:10.3109/01902148209069653", "doi:10.7554/eLife.78216" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000271", "lbl" : "lung ciliated cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any ciliated cell that is part of some lung.", + "xrefs" : [ "FBC:Autogenerated" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000272", "lbl" : "lung secretory cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any secretory cell that is part of some lung.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000274", "lbl" : "trophectodermal cell", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000275", + "lbl" : "smooth muscle cell of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the small intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:15050" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000276", + "lbl" : "smooth muscle fiber of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the duodenum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:15058" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000279", + "lbl" : "smooth muscle cell of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the large intestine.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:15653" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000280", + "lbl" : "smooth muscle cell of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the colon.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:15663" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000285", + "lbl" : "smooth muscle cell of sigmoid colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the sigmoid colon.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:17521" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000286", + "lbl" : "smooth muscle cell of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the rectum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:17522" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000303", "lbl" : "fibroblast of areolar connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast that is part of the areolar connective tissue.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261279" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000306", "lbl" : "fibroblast of tunica adventitia of artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast that is part of the tunica adventitia of artery.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261285" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000307", "lbl" : "fibroblast of dense regular elastic tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fibroblast that is part of the dense regular elastic tissue.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261287" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000309", "lbl" : "epicardial adipocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An adipocyte that is part of the epicardial fat.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261293" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000310", "lbl" : "adipocyte of epicardial fat of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipocyte that is part of the epicardial fat of right ventricle.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261297" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000311", "lbl" : "adipocyte of epicardial fat of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipocyte that is part of the epicardial fat of left ventricle.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:261300" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000330", "lbl" : "serous cell of epithelium of trachea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A serous secreting cell that is part of the epithelium of trachea.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263078" } ] } }, { @@ -2341,43 +5951,120 @@ "lbl" : "serous cell of epithelium of bronchus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A serous secreting cell that is part of the epithelium of bronchus.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263080" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000332", "lbl" : "serous cell of epithelium of terminal bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous secreting cell that is part of the epithelium of terminal bronchiole.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263082" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000361", "lbl" : "transitional myocyte of interatrial septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transitional myocyte that is part of the interatrial septum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263152" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000362", "lbl" : "transitional myocyte of interventricular septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transitional myocyte that is part of the interventricular septum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263154" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000376", "lbl" : "Purkinje myocyte of interventricular septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A Purkinje myocyte that is part of the interventricular septum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:263182" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000398", + "lbl" : "endothelial cell of hepatic sinusoid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates.", + "xrefs" : [ "GOC:tfm", "PMID:3926620" ] + }, + "xrefs" : [ { + "val" : "BTO:000125" + }, { + "val" : "FMA:62911" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000409", "lbl" : "myocyte of sinoatrial node", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle cell that is part of the sinoatrial node.", + "xrefs" : [ "FMA:67102", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67102" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000410", "lbl" : "myocyte of atrioventricular node", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle cell that is part of the atrioventricular node.", + "xrefs" : [ "FMA:67106", "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67106" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000412", "lbl" : "endothelial cell of arteriole", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell that is part of the arteriole.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67760" + }, { + "val" : "KUPO:0001097" } ] } }, { @@ -2385,9 +6072,16 @@ "lbl" : "endothelial cell of artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A blood vessel endothelial cell that is part of an arterial endothelium.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "BTO:0004758" + }, { + "val" : "FMA:67761" + }, { + "val" : "KUPO:0001095" } ] } }, { @@ -2395,251 +6089,753 @@ "lbl" : "endothelial cell of venule", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelial cell that is part of the venule.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67762" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000415", + "lbl" : "epithelial cell of gallbladder", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell that is part of the gallbladder.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:67780" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000428", "lbl" : "stem cell of epidermis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A somatic stem cell that is part of the epidermis.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70541" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000443", "lbl" : "ciliary muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle cell that is part of the ciliary body.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70610" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000444", "lbl" : "mesothelial cell of anterior chamber of eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the anterior chamber of eyeball.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70615" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000456", "lbl" : "mesothelial cell of parietal peritoneum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the parietal peritoneum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:72142" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000457", "lbl" : "mesothelial cell of visceral peritoneum", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mesothelial cell that is part of the visceral peritoneum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:72143" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000478", "lbl" : "transitional myocyte of sinoatrial node", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transitional myocyte that is part of the sinoatrial node.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83384" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000479", "lbl" : "Purkinje myocyte of atrioventricular node", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A Purkinje myocyte that is part of the atrioventricular node.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83386" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000482", "lbl" : "myocardial endocrine cell of interventricular septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myocardial endocrine cell that is part of the interventricular septum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:83390" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1000488", + "lbl" : "cholangiocyte", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.", + "xrefs" : [ "GOC:tfm", "PMID:16550043", "PMID:18356246" ] + }, + "xrefs" : [ { + "val" : "FMA:86481" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000490", "lbl" : "mesothelial cell of peritoneum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the peritoneum.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:86736" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000491", "lbl" : "mesothelial cell of pleura", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the pleura.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:86737" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000492", "lbl" : "mesothelial cell of parietal pleura", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelial cell that is part of the parietal pleura.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:86738" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1000493", "lbl" : "mesothelial cell of visceral pleura", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mesothelial cell that is part of the visceral pleura.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:86739" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001433", + "lbl" : "epithelial cell of exocrine pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial cell of the exocrine pancreas.", + "xrefs" : [ "GOC:tfm" ] + }, + "xrefs" : [ { + "val" : "FMA:70986" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001516", + "lbl" : "intestinal enteroendocrine cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract.", + "xrefs" : [ "MP:0010802" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001567", "lbl" : "lung endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any endothelial cell of vascular tree that is part of some lung.", + "xrefs" : [ "FBC:Autogenerated" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001568", "lbl" : "pulmonary artery endothelial cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Any endothelial cell of vascular tree that is part of some pulmonary artery.", + "xrefs" : [ "FBC:Autogenerated" ] + }, + "xrefs" : [ { + "val" : "BTO:0001141" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001572", + "lbl" : "colon endothelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vascular endothelial cell found in colon blood vessels.", + "xrefs" : [ "NPX:PDR", "https://orcid.org/0000-0001-5208-3432" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2397" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001576", "lbl" : "oral mucosa squamous cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Squamous cell of oral epithelium.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1252" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001588", + "lbl" : "colon glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1274" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001589", + "lbl" : "duodenum glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1275" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001592", + "lbl" : "gallbladder glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Glandular cell of gallbladder epithelium.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1278" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001595", + "lbl" : "rectum glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1281" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001598", + "lbl" : "small intestine glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) .", + "xrefs" : [ "NCI_Thesaurus:Small_Intestinal_Glandular_Cell", "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1286" + }, { + "val" : "FMA:86928" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_1001599", + "lbl" : "pancreas exocrine glandular cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts.", + "xrefs" : [ "HPA:HPA", "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "BTO:0000028" + }, { + "val" : "CALOHA:TS-1242" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001603", "lbl" : "lung macrophage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung.", + "xrefs" : [ "HPA:HPA", "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0576" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001609", "lbl" : "muscle fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fibroblast from muscle organ.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0643" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_1001610", "lbl" : "bone marrow hematopoietic cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes.", + "xrefs" : [ "NPX:PDR" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2109" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000001", "lbl" : "peripheral blood mononuclear cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000008", "lbl" : "microvascular endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any blood vessel endothelial cell that is part of a microvascular endothelium.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000010", "lbl" : "dermis blood vessel endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any blood vessel endothelial cell that is part of a dermis.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000013", "lbl" : "fibroblast of skin of abdomen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any skin fibroblast that is part of a skin of abdomen.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000016", "lbl" : "lung microvascular endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any lung endothelial cell that is part of a microvascular endothelium.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000019", "lbl" : "compound eye photoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any photoreceptor cell that is part of a compound eye.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000020", "lbl" : "inner cell mass cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any native cell that is part of a inner cell mass.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000022", "lbl" : "cardiac septum cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any native cell that is part of a cardiac septum.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000029", "lbl" : "central nervous system neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neuron that is part of a central nervous system.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000032", "lbl" : "peripheral nervous system neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A neuron that is part of a peripheral nervous system.", + "xrefs" : [ "GOC:TermGenie", "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "FMA:84664" } ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000042", "lbl" : "embryonic fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a embryo.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000043", "lbl" : "brain pericyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any pericyte cell that is part of a brain.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000044", "lbl" : "brain microvascular endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microvascular endothelial cell that is part of a brain.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000046", "lbl" : "ventricular cardiac muscle cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cardiac muscle cell that is part of a cardiac ventricle.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000047", "lbl" : "brainstem motor neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any motor neuron that is part of a brainstem.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_2000051", + "lbl" : "splenic fibroblast", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a spleen.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_2000053", + "lbl" : "splenic endothelial cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any endothelial cell that is part of a spleen.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=5500" ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_2000055", + "lbl" : "liver dendritic cell", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any dendritic cell that is part of a liver.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.jleukbio.org/content/66/2/322.abstract" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000063", "lbl" : "ovarian fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a female gonad.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=7330" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000064", "lbl" : "ovarian surface epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any epithelial cell that is part of a female gonad.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=7310" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000066", "lbl" : "cardiac ventricle fibroblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any fibroblast that is part of a cardiac ventricle.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=6310" ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000067", "lbl" : "cardiac atrium fibroblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any fibroblast that is part of a cardiac atrium.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=6320" ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000068", "lbl" : "pericardium fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a pericardium.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=6430" ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_2000069", + "lbl" : "gallbladder fibroblast", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a gallbladder.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=5430" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000070", "lbl" : "optic choroid fibroblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast that is part of a optic choroid.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=6620" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000072", "lbl" : "adipose microvascular endothelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microvascular endothelial cell that is part of a adipose tissue.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "http://www.sciencellonline.com/site/productInformation.php?keyword=7200" ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000073", "lbl" : "migratory cardiac neural crest cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any migratory neural crest cell that is part of a cardiac neural crest.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_2000074", + "lbl" : "splenocyte", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any leukocyte that is part of a spleen.", + "xrefs" : [ "GOC:TermGenie" ] + }, + "comments" : [ "Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology." ] + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000080", "lbl" : "mesenchymal stem cell of abdominal adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any mesenchymal stem cell of adipose tissue that is part of an abdomen.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_2000093", "lbl" : "bronchus fibroblast of lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fibroblast of lung that is part of a bronchus.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_3000000", "lbl" : "ciliated epithelial cell of esophagus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ciliated epithelial cell of the esophagus.", + "xrefs" : [ "GOC:CellBLAST", "PMID:29802404" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_3000004", "lbl" : "peripheral sensory neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Peripheral sensory neuron.", + "xrefs" : [ "GOC:CellBLAST", "PMID:30096314" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4023072", "lbl" : "brain vascular cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A cell that is part of the brain vasculature.", + "xrefs" : [ "DOI:10.1101/2022.10.12.511898" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_4023079", "lbl" : "midbrain-derived inhibitory neuron", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A GABAergic inhibitory neuron that is derived from the midbrain.", + "xrefs" : [ "DOI:10.1101/2022.10.12.511898" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_4023168", "lbl" : "somatosensory neuron", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli.", + "xrefs" : [ "PMID:22865660" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4028001", "lbl" : "pulmonary capillary endothelial cell", @@ -2654,87 +6850,165 @@ "lbl" : "alveolar type 1 fibroblast cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets.", + "xrefs" : [ "PMID:22268140", "PMID:26706109", "PMID:28886382", "PMID:29489752", "PMID:30675802", "PMID:33624948", "PMID:33707239", "PMID:9074756" ] + }, + "comments" : [ "A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_4028006", "lbl" : "alveolar adventitial fibroblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia.", + "xrefs" : [ "PMID:26706109", "PMID:28886382", "PMID:29752282", "PMID:30675802", "PMID:33208946", "PMID:33624948" ] + }, + "comments" : [ "A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_4030029", "lbl" : "blood lymphocyte", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lymphocyte located in blood.", + "xrefs" : [ "https://orcid.org/0000-0001-9990-8331" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4030031", "lbl" : "interstitial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes.", + "xrefs" : [ "PMID:24987007" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4030034", "lbl" : "respiratory ciliated cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium.", + "xrefs" : [ "PMID:18757316", "PMID:21364219" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033005", + "lbl" : "serous secreting cell of bronchus submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland.", + "xrefs" : [ "PMID:5487122", "PMID:9651178" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033008", "lbl" : "vein endothelial cell of respiratory system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A(n) vein endothelial cell that is part of a(n) respiratory system.", + "xrefs" : [ "PMID:34030460" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033017", "lbl" : "bronchiolar smooth muscle cell", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A smooth muscle cell that is part of a bronchiole.", + "xrefs" : [ "ISBN:9781260462982", "PMID:15347627" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033018", "lbl" : "lung megakaryocyte", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A megakaryocyte that is resident in the lung connective tissue.", + "xrefs" : [ "PMID:33351116" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033020", + "lbl" : "mucus secreting cell of trachea gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucus secreting cell that is part of a submucosal gland of the trachea.", + "xrefs" : [ "PMID:18931053", "PMID:29656943" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033022", + "lbl" : "mucus secreting cell of bronchus submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucus secreting cell of a submucosal gland of the bronchus.", + "xrefs" : [ "PMID:19965983" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033037", + "lbl" : "mucus secreting cell of tracheobronchial tree submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucus secreting cell of a submucosal gland of the tracheobronchial tree.", + "xrefs" : [ "PMID:30864819" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033041", "lbl" : "CCL3-positive alveolar macrophage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An alveolar macrophage that expresses CCL3.", + "xrefs" : [ "PMID:37291214" ] + }, + "comments" : [ "A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033042", "lbl" : "metallothionein-positive alveolar macrophage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An alveolar macrophage that expresses metallothionein.", + "xrefs" : [ "PMID:37291214" ] + }, + "comments" : [ "A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41." ] } }, { "id" : "http://purl.obolibrary.org/obo/CL_4033054", "lbl" : "perivascular cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics.", + "xrefs" : [ "PMID:24928499", "PMID:27889329" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/CL_4033061", + "lbl" : "endothelial cell of central vein of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelial cell that is part of a central vein of liver.", + "xrefs" : [ "PMID:28287163" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4037001", "lbl" : "NS forest marker set of alveolar adventitial fibroblast (Human Lung).", @@ -2798,13014 +7072,37803 @@ }, { "id" : "http://purl.obolibrary.org/obo/CL_4040003", "lbl" : "fetal pre-type II pulmonary alveolar epithelial cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity.", + "xrefs" : [ "PMID:1316350" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/CL_4040004", "lbl" : "mesenchymal stem cell of orbital adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any mesenchymal stem cell of adipose tissue that is part of an orbital region.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000011", "lbl" : "vacuole inheritance", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.", + "xrefs" : [ "GOC:mcc", "PMID:10873824", "PMID:14616069" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000070", "lbl" : "mitotic sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.", + "xrefs" : [ "GOC:ai", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000139", "lbl" : "Golgi membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding any of the compartments of the Golgi apparatus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000226", "lbl" : "microtubule cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000228", "lbl" : "nuclear chromosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.", + "xrefs" : [ "GOC:dph", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000271", "lbl" : "polysaccharide biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0000272", + "lbl" : "polysaccharide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.", + "xrefs" : [ "PMID:33139480" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000278", "lbl" : "mitotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + }, + "comments" : [ "Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle." ], + "xrefs" : [ { + "val" : "Wikipedia:Mitosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000280", "lbl" : "nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000313", "lbl" : "organellar ribosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ribosome contained within a subcellular membrane-bounded organelle.", + "xrefs" : [ "GOC:mah", "GOC:mcc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000323", "lbl" : "lytic vacuole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000740", "lbl" : "nuclear membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of 2 or more lipid bilayer membranes that surround the nucleus.", + "xrefs" : [ "GOC:elh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000741", "lbl" : "karyogamy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.", + "xrefs" : [ "GOC:elh" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Karyogamy" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000768", "lbl" : "syncytium formation by plasma membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.", + "xrefs" : [ "GOC:mtg_muscle", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000785", "lbl" : "chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.", + "xrefs" : [ "GOC:elh", "PMID:20404130" ] + }, + "comments" : [ "Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1615953555" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000791", "lbl" : "euchromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.", + "xrefs" : [ "PMID:32017156" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao445485807" + }, { + "val" : "Wikipedia:Euchromatin" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000792", "lbl" : "heterochromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A compact and highly condensed form of chromatin that is refractory to transcription.", + "xrefs" : [ "PMID:32017156" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao581845896" + }, { + "val" : "Wikipedia:Heterochromatin" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000819", "lbl" : "sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.", + "xrefs" : [ "GOC:ai", "GOC:elh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0000902", "lbl" : "cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process in which the size or shape of a cell is generated and organized.", + "xrefs" : [ "GOC:clt", "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001501", "lbl" : "skeletal system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001503", "lbl" : "ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.", + "xrefs" : [ "GOC:mtg_mpo", "PMID:17572649" ] + }, + "comments" : [ "Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'." ], + "xrefs" : [ { + "val" : "Wikipedia:Ossification" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001508", "lbl" : "action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb", "ISBN:978-0-07-139011-8" ] + }, + "comments" : [ "Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001525", "lbl" : "angiogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.", + "xrefs" : [ "ISBN:0878932453" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Angiogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001539", "lbl" : "cilium or flagellum-dependent cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.", + "xrefs" : [ "GOC:cilia", "GOC:hjd", "GOC:krc" ] + }, + "comments" : [ "Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001555", "lbl" : "oocyte growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.", + "xrefs" : [ "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001556", "lbl" : "oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.", + "xrefs" : [ "GOC:devbiol", "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Oocyte_maturation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001558", "lbl" : "regulation of cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, extent or direction of cell growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001560", "lbl" : "regulation of cell growth by extracellular stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001568", "lbl" : "blood vessel development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.", + "xrefs" : [ "GOC:hjd", "UBERON:0001981" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001569", "lbl" : "branching involved in blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001570", "lbl" : "vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.", + "xrefs" : [ "PMID:8999798" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Vasculogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001578", "lbl" : "microtubule bundle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in a parallel arrangement of microtubules.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001654", "lbl" : "eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.", + "xrefs" : [ "GOC:jid", "GOC:jl" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Eye_development" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0001655", + "lbl" : "urogenital system development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001659", "lbl" : "temperature homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process in which an organism modulates its internal body temperature.", + "xrefs" : [ "GOC:jl" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Thermoregulation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001666", "lbl" : "response to hypoxia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.", + "xrefs" : [ "GOC:hjd" ] + }, + "comments" : [ "Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001667", "lbl" : "ameboidal-type cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell migration that is accomplished by extension and retraction of a pseudopodium.", + "xrefs" : [ "GOC:dph" ] + }, + "comments" : [ "Note that this term refers to a mode of migration rather than to any particular cell type." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001674", "lbl" : "female germ cell nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The nucleus of the female germ cell, a reproductive cell in females.", + "xrefs" : [ "CL:0000021", "GOC:hjd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001677", "lbl" : "formation of translation initiation ternary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).", + "xrefs" : [ "GOC:hjd" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0001678", + "lbl" : "intracellular glucose homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of glucose within a cell.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001696", "lbl" : "gastric acid secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.", + "xrefs" : [ "GOC:hjd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001700", "lbl" : "embryonic development via the syncytial blastoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001701", "lbl" : "in utero embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001704", "lbl" : "formation of primary germ layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the ectoderm, mesoderm and endoderm during gastrulation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001705", "lbl" : "ectoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of ectoderm during gastrulation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001706", "lbl" : "endoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the endoderm during gastrulation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001707", "lbl" : "mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001743", "lbl" : "lens placode formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The initial developmental process that will lead to the formation of an eye.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001745", "lbl" : "compound eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:dph", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001751", "lbl" : "compound eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001754", "lbl" : "eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001755", "lbl" : "neural crest cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb", "ISBN:0878932437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001756", "lbl" : "somitogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.", + "xrefs" : [ "ISBN:0721662544" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Somitogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001763", "lbl" : "morphogenesis of a branching structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.", + "xrefs" : [ "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001764", "lbl" : "neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.", + "xrefs" : [ "CL:0000540", "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Neural_development#Neuron_migration" + }, { + "val" : "Wikipedia:Neuron_migration" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001767", "lbl" : "establishment of lymphocyte polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.", + "xrefs" : [ "GOC:mgi_curators", "PMID:11244041", "PMID:12615889" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001768", "lbl" : "establishment of T cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.", + "xrefs" : [ "GOC:mgi_curators", "PMID:11244041", "PMID:12615889" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001773", "lbl" : "myeloid dendritic cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001775", "lbl" : "cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell.", + "xrefs" : [ "GOC:mgi_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001776", "lbl" : "leukocyte homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001777", "lbl" : "T cell homeostatic proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001816", "lbl" : "cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001817", "lbl" : "regulation of cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of production of a cytokine.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001818", "lbl" : "negative regulation of cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the rate of production of a cytokine.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001819", "lbl" : "positive regulation of cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of production of a cytokine.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001820", "lbl" : "serotonin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.", + "xrefs" : [ "GOC:ef", "ISBN:0198506732", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001824", "lbl" : "blastocyst development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001825", "lbl" : "blastocyst formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The initial formation of a blastocyst from a solid ball of cells known as a morula.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001826", "lbl" : "inner cell mass cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001829", "lbl" : "trophectodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001831", "lbl" : "trophectodermal cellular morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenesis of trophectoderm cells.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001832", "lbl" : "blastocyst growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001833", "lbl" : "inner cell mass cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The proliferation of cells in the inner cell mass.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001834", "lbl" : "trophectodermal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The proliferation of cells in the trophectoderm.", + "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ] + }, + "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001837", "lbl" : "epithelial to mesenchymal transition", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.", + "xrefs" : [ "GOC:dph", "PMID:14701881" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001838", "lbl" : "embryonic epithelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenesis of an embryonic epithelium into a tube-shaped structure.", + "xrefs" : [ "GOC:dph", "ISBN:0824072820" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001839", "lbl" : "neural plate morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.", + "xrefs" : [ "GOC:dph", "ISBN:0878932437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001840", "lbl" : "neural plate development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.", + "xrefs" : [ "GOC:dph", "GOC:ef", "ISBN:0878932437", "ISBN:0878932585" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001841", "lbl" : "neural tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.", + "xrefs" : [ "GOC:dph", "ISBN:0878932437" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Neurulation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001842", "lbl" : "neural fold formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.", + "xrefs" : [ "GOC:dph", "ISBN:0878932437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001878", "lbl" : "response to yeast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.", + "xrefs" : [ "PMID:14707091" ] + }, + "comments" : [ "defined as response to Saccharomycotina (true yeasts). This excludes fission yeast." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001885", "lbl" : "endothelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of an endothelial cell over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001886", "lbl" : "endothelial cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0001889", + "lbl" : "liver development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.", + "xrefs" : [ "GOC:add", "ISBN:068340007X" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001894", "lbl" : "tissue homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.", + "xrefs" : [ "GOC:add", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001935", "lbl" : "endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001936", "lbl" : "regulation of endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001937", "lbl" : "negative regulation of endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001938", "lbl" : "positive regulation of endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of endothelial cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001944", "lbl" : "vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.", + "xrefs" : [ "GOC:dph", "UBERON:0002409" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001955", "lbl" : "blood vessel maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0001957", "lbl" : "intramembranous ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.", + "xrefs" : [ "ISBN:0878932437" ] + }, + "comments" : [ "An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division." ], + "xrefs" : [ { + "val" : "Wikipedia:Intramembranous_ossification" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002009", "lbl" : "morphogenesis of an epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:tb", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002011", "lbl" : "morphogenesis of an epithelial sheet", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002027", "lbl" : "regulation of heart rate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency or rate of heart contraction.", + "xrefs" : [ "GOC:dph", "GOC:tb", "PMID:10358008" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002052", "lbl" : "positive regulation of neuroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate of neuroblast proliferation.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002053", "lbl" : "positive regulation of mesenchymal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002062", "lbl" : "chondrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002063", "lbl" : "chondrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002064", "lbl" : "epithelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002065", "lbl" : "columnar/cuboidal epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002066", "lbl" : "columnar/cuboidal epithelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002067", "lbl" : "glandular epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002068", "lbl" : "glandular epithelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002069", "lbl" : "columnar/cuboidal epithelial cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002070", "lbl" : "epithelial cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002071", "lbl" : "glandular epithelial cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002072", "lbl" : "optic cup morphogenesis involved in camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.", + "xrefs" : [ "GOC:dph", "GOC:mtg_sensu", "GOC:sdb_2009", "GOC:tb", "ISBN:0878932437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002085", "lbl" : "inhibition of neuroepithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.", + "xrefs" : [ "GOC:dph", "PMID:16678814" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002087", "lbl" : "regulation of respiratory gaseous exchange by nervous system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.", + "xrefs" : [ "GOC:dph", "GOC:tb", "PMID:12458206" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002088", "lbl" : "lens development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.", + "xrefs" : [ "GOC:dph", "ISBN:0582064333" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002089", "lbl" : "lens morphogenesis in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.", + "xrefs" : [ "GOC:dph", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002158", "lbl" : "osteoclast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.", + "xrefs" : [ "CL:0000092", "GOC:hjd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002213", "lbl" : "defense response to insect", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002232", "lbl" : "leukocyte chemotaxis involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002233", "lbl" : "leukocyte chemotaxis involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of an immune cell in response to an external stimulus a part of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002244", "lbl" : "hematopoietic progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.", + "xrefs" : [ "GOC:add", "GOC:rl", "ISBN:0781735149", "PMID:16551251" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002250", "lbl" : "adaptive immune response", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0002252", - "lbl" : "immune effector process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Adaptive_immune_system" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/GO_0002260", + "id" : "http://purl.obolibrary.org/obo/GO_0002251", + "lbl" : "organ or tissue specific immune response", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.", + "xrefs" : [ "GOC:jal", "GO_REF:0000022" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0002252", + "lbl" : "immune effector process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0002260", "lbl" : "lymphocyte homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "GOC:add", "PMID:15826826", "PMID:16319493", "PMID:16551252", "PMID:16551262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002262", "lbl" : "myeloid cell homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "CL:0000763", "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002263", "lbl" : "cell activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002264", "lbl" : "endothelial cell activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002269", "lbl" : "leukocyte activation involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002274", "lbl" : "myeloid leukocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002275", "lbl" : "myeloid cell activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002277", "lbl" : "myeloid dendritic cell activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002280", "lbl" : "monocyte activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:16551245" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002281", "lbl" : "macrophage activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002284", "lbl" : "myeloid dendritic cell differentiation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002285", "lbl" : "lymphocyte activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002286", "lbl" : "T cell activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002292", "lbl" : "T cell differentiation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002309", "lbl" : "T cell proliferation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a T cell population by cell division as part of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002318", "lbl" : "myeloid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.", + "xrefs" : [ "GOC:add", "PMID:16551264" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002320", "lbl" : "lymphoid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.", + "xrefs" : [ "GOC:add", "PMID:16551251", "PMID:16551264" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002351", "lbl" : "serotonin production involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:16730260" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002366", "lbl" : "leukocyte activation involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002367", "lbl" : "cytokine production involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002369", "lbl" : "T cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that contributes to cytokine production by a T cell.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002371", "lbl" : "dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that contributes to cytokine production by a dendritic cell.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002372", "lbl" : "myeloid dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that contributes to cytokine production by a myeloid dendritic cell.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002376", "lbl" : "immune system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.", + "xrefs" : [ "GOC:add", "GO_REF:0000022" ] + }, + "comments" : [ "Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501)." ], + "xrefs" : [ { + "val" : "Wikipedia:Immune_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0002384", + "lbl" : "hepatic immune response", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immune response taking place in the liver.", + "xrefs" : [ "GOC:jal", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002396", "lbl" : "MHC protein complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15771591", "PMID:15928678" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002399", "lbl" : "MHC class II protein complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15771591" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002407", "lbl" : "dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a dendritic cell in response to an external stimulus.", + "xrefs" : [ "CL:0000451", "GOC:add", "ISBN:0781735149", "PMID:15814331", "PMID:16056255" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002408", "lbl" : "myeloid dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a myeloid dendritic cell in response to an external stimulus.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15814331", "PMID:16056255" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002440", "lbl" : "production of molecular mediator of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002442", "lbl" : "serotonin secretion involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of serotonin by a cell as part of an inflammatory response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002443", "lbl" : "leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the carrying out of an immune response by a leukocyte.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002444", "lbl" : "myeloid leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the carrying out of an immune response by a myeloid leukocyte.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002449", "lbl" : "lymphocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the carrying out of an immune response by a lymphocyte.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002456", "lbl" : "T cell mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the carrying out of an immune response by a T cell.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002457", "lbl" : "T cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "PMID:11417857", "PMID:15120183" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002460", "lbl" : "adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.", + "xrefs" : [ "GOC:add", "GOC:mtg_sensu", "ISBN:0781735149", "ISBN:1405196831" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002468", "lbl" : "dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15771591" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002469", "lbl" : "myeloid dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15771591" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002471", "lbl" : "monocyte antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "PMID:11200054" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002472", "lbl" : "macrophage antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15771591" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002504", "lbl" : "antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15531770", "PMID:15771591", "PMID:16153240" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002520", "lbl" : "immune system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.", + "xrefs" : [ "GOC:add", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002521", "lbl" : "leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.", + "xrefs" : [ "CL:0000738", "GOC:add", "PMID:16551264" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002522", "lbl" : "leukocyte migration involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:14680625", "PMID:14708592", "PMID:7507411", "PMID:8600538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002523", "lbl" : "leukocyte migration involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:14680625", "PMID:14708592", "PMID:7507411", "PMID:8600538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002532", "lbl" : "production of molecular mediator involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "GOC:dph", "GOC:tb", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002534", "lbl" : "cytokine production involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002548", "lbl" : "monocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a monocyte in response to an external stimulus.", + "xrefs" : [ "GOC:add", "PMID:11696603", "PMID:15173832" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002572", "lbl" : "pro-T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002573", "lbl" : "myeloid leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.", + "xrefs" : [ "GOC:add", "PMID:16551251" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002577", "lbl" : "regulation of antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002578", "lbl" : "negative regulation of antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002579", "lbl" : "positive regulation of antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002580", "lbl" : "regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002581", "lbl" : "negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002582", "lbl" : "positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002604", "lbl" : "regulation of dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002605", "lbl" : "negative regulation of dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002606", "lbl" : "positive regulation of dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002607", "lbl" : "regulation of myeloid dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002608", "lbl" : "negative regulation of myeloid dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002609", "lbl" : "positive regulation of myeloid dendritic cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002613", "lbl" : "regulation of monocyte antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002614", "lbl" : "negative regulation of monocyte antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002615", "lbl" : "positive regulation of monocyte antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002616", "lbl" : "regulation of macrophage antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002617", "lbl" : "negative regulation of macrophage antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002618", "lbl" : "positive regulation of macrophage antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002625", "lbl" : "regulation of T cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002626", "lbl" : "negative regulation of T cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002627", "lbl" : "positive regulation of T cell antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002682", "lbl" : "regulation of immune system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of an immune system process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002683", "lbl" : "negative regulation of immune system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002684", "lbl" : "positive regulation of immune system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of an immune system process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002685", "lbl" : "regulation of leukocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of leukocyte migration.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002686", "lbl" : "negative regulation of leukocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002687", "lbl" : "positive regulation of leukocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of leukocyte migration.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002688", "lbl" : "regulation of leukocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002689", "lbl" : "negative regulation of leukocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002690", "lbl" : "positive regulation of leukocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002694", "lbl" : "regulation of leukocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of leukocyte activation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002695", "lbl" : "negative regulation of leukocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002696", "lbl" : "positive regulation of leukocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of leukocyte activation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002697", "lbl" : "regulation of immune effector process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of an immune effector process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002698", "lbl" : "negative regulation of immune effector process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002699", "lbl" : "positive regulation of immune effector process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of an immune effector process.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002700", "lbl" : "regulation of production of molecular mediator of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002701", "lbl" : "negative regulation of production of molecular mediator of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002702", "lbl" : "positive regulation of production of molecular mediator of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002703", "lbl" : "regulation of leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002704", "lbl" : "negative regulation of leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002705", "lbl" : "positive regulation of leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002706", "lbl" : "regulation of lymphocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002707", "lbl" : "negative regulation of lymphocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002708", "lbl" : "positive regulation of lymphocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002709", "lbl" : "regulation of T cell mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of T cell mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002710", "lbl" : "negative regulation of T cell mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002711", "lbl" : "positive regulation of T cell mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002718", "lbl" : "regulation of cytokine production involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002719", "lbl" : "negative regulation of cytokine production involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002720", "lbl" : "positive regulation of cytokine production involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002724", "lbl" : "regulation of T cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of T cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002725", "lbl" : "negative regulation of T cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002726", "lbl" : "positive regulation of T cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002730", "lbl" : "regulation of dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002731", "lbl" : "negative regulation of dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002732", "lbl" : "positive regulation of dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002733", "lbl" : "regulation of myeloid dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002734", "lbl" : "negative regulation of myeloid dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002735", "lbl" : "positive regulation of myeloid dendritic cell cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002761", "lbl" : "regulation of myeloid leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002762", "lbl" : "negative regulation of myeloid leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002763", "lbl" : "positive regulation of myeloid leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002790", "lbl" : "peptide secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of a peptide from a cell or a tissue.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002791", "lbl" : "regulation of peptide secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of peptide secretion.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002792", "lbl" : "negative regulation of peptide secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002793", "lbl" : "positive regulation of peptide secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of peptide secretion.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002819", "lbl" : "regulation of adaptive immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of an adaptive immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002820", "lbl" : "negative regulation of adaptive immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002821", "lbl" : "positive regulation of adaptive immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002822", "lbl" : "regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.", + "xrefs" : [ "GOC:add", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002823", "lbl" : "negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.", + "xrefs" : [ "GOC:add", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002824", "lbl" : "positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.", + "xrefs" : [ "GOC:add", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002831", "lbl" : "regulation of response to biotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.", + "xrefs" : [ "GOC:add" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002832", "lbl" : "negative regulation of response to biotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.", + "xrefs" : [ "GOC:add" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002833", "lbl" : "positive regulation of response to biotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.", + "xrefs" : [ "GOC:add" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002886", "lbl" : "regulation of myeloid leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002887", "lbl" : "negative regulation of myeloid leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002888", "lbl" : "positive regulation of myeloid leukocyte mediated immunity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0002932", "lbl" : "tendon sheath development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move.", + "xrefs" : [ "PMID:20696843" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003002", "lbl" : "regionalization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003006", "lbl" : "developmental process involved in reproduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003007", "lbl" : "heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003008", "lbl" : "system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.", + "xrefs" : [ "GOC:mtg_cardio" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003009", "lbl" : "skeletal muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.", + "xrefs" : [ "GOC:mtg_cardio", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003012", "lbl" : "muscle system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.", + "xrefs" : [ "GOC:mtg_cardio" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003013", "lbl" : "circulatory system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.", + "xrefs" : [ "GOC:mtg_cardio" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Circulatory_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003014", + "lbl" : "renal system process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).", + "xrefs" : [ "GOC:cjm", "GOC:mtg_cardio", "GOC:mtg_kidney_jan10" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003015", "lbl" : "heart process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.", + "xrefs" : [ "GOC:mtg_cardio" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003016", "lbl" : "respiratory system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.", + "xrefs" : [ "GOC:dph", "GOC:mtg_cardio", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003032", "lbl" : "detection of oxygen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal.", + "xrefs" : [ "GOC:mtg_cardio" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003131", "lbl" : "mesodermal-endodermal cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from mesodermal cells to endodermal cells.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003133", "lbl" : "endodermal-mesodermal cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from endodermal cells to mesodermal cells.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003142", "lbl" : "cardiogenic plate morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003143", "lbl" : "embryonic heart tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003144", "lbl" : "embryonic heart tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003145", "lbl" : "embryonic heart tube formation via epithelial folding", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003147", "lbl" : "neural crest cell migration involved in heart formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003148", "lbl" : "outflow tract septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003149", "lbl" : "membranous septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003150", "lbl" : "muscular septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003151", "lbl" : "outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.", + "xrefs" : [ "GOC:mtg_heart", "UBERON:0004145" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003152", "lbl" : "morphogenesis of an epithelial fold involved in embryonic heart tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003156", "lbl" : "regulation of animal organ formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003157", "lbl" : "endocardium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003158", "lbl" : "endothelium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003159", "lbl" : "morphogenesis of an endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003160", "lbl" : "endocardium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003161", "lbl" : "cardiac conduction system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003162", "lbl" : "atrioventricular node development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003163", "lbl" : "sinoatrial node development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003164", "lbl" : "His-Purkinje system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003165", "lbl" : "Purkinje myocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.", + "xrefs" : [ "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003168", "lbl" : "Purkinje myocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.", + "xrefs" : [ "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003169", "lbl" : "coronary vein morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of veins of the heart are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003197", "lbl" : "endocardial cushion development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003203", "lbl" : "endocardial cushion morphogenesis", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0003204", - "lbl" : "cardiac skeleton development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003204", + "lbl" : "cardiac skeleton development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003205", "lbl" : "cardiac chamber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003206", "lbl" : "cardiac chamber morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003207", "lbl" : "cardiac chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003208", "lbl" : "cardiac ventricle morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003209", "lbl" : "cardiac atrium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003210", "lbl" : "cardiac atrium formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003211", "lbl" : "cardiac ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003212", "lbl" : "cardiac left atrium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the left cardiac atrium is generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003213", "lbl" : "cardiac right atrium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the right cardiac atrium is generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003214", "lbl" : "cardiac left ventricle morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the left cardiac ventricle is generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003215", "lbl" : "cardiac right ventricle morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the right cardiac ventricle is generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003216", "lbl" : "cardiac left atrium formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003217", "lbl" : "cardiac right atrium formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003218", "lbl" : "cardiac left ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003219", "lbl" : "cardiac right ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003220", "lbl" : "left ventricular cardiac muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003221", "lbl" : "right ventricular cardiac muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003222", + "lbl" : "ventricular trabecula myocardium morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003225", + "lbl" : "left ventricular trabecular myocardium morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003227", + "lbl" : "right ventricular trabecular myocardium morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the right ventricular myocardium are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003228", "lbl" : "atrial cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003229", "lbl" : "ventricular cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003230", "lbl" : "cardiac atrium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003231", "lbl" : "cardiac ventricle development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003235", "lbl" : "sinus venosus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003236", "lbl" : "sinus venosus morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003237", "lbl" : "sinus venosus formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003241", "lbl" : "growth involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Developmental growth that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003245", "lbl" : "cardiac muscle tissue growth involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003248", "lbl" : "heart capillary growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003253", "lbl" : "cardiac neural crest cell migration involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003260", "lbl" : "cardioblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003272", "lbl" : "endocardial cushion formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.", + "xrefs" : [ "GOC:mtg_heart", "PMID:15797462" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003273", "lbl" : "cell migration involved in endocardial cushion formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003275", "lbl" : "apoptotic process involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003277", "lbl" : "apoptotic process involved in endocardial cushion morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003278", "lbl" : "apoptotic process involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003279", "lbl" : "cardiac septum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a cardiac septum over time, from its initial formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003281", "lbl" : "ventricular septum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the ventricular septum over time from its formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003283", "lbl" : "atrial septum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the atrial septum over time, from its initial formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003292", "lbl" : "cardiac septum cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an endocardial cushion cell becomes a cell of a cardiac septum.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003298", "lbl" : "physiological muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003300", "lbl" : "cardiac muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003301", "lbl" : "physiological cardiac muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003309", + "lbl" : "type B pancreatic cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.", + "xrefs" : [ "CL:0000169", "GOC:dph", "PMID:11076772" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003310", + "lbl" : "pancreatic A cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.", + "xrefs" : [ "GOC:dph", "PMID:11076772" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003311", + "lbl" : "pancreatic D cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.", + "xrefs" : [ "GOC:dph", "PMID:11076772" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003312", + "lbl" : "pancreatic PP cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.", + "xrefs" : [ "GOC:dph", "PMID:11076772" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003313", "lbl" : "heart rudiment development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003314", "lbl" : "heart rudiment morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the heart rudiment are generated and organized.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003315", "lbl" : "heart rudiment formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of the heart rudiment.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003322", + "lbl" : "pancreatic A cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003323", + "lbl" : "type B pancreatic cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.", + "xrefs" : [ "CL:0000169", "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003324", + "lbl" : "pancreatic D cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003325", + "lbl" : "pancreatic PP cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003341", "lbl" : "cilium movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed, self-propelled movement of a cilium.", + "xrefs" : [ "GOC:dph", "GOC:jl" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003342", "lbl" : "proepicardium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.", + "xrefs" : [ "GOC:dph", "PMID:18722343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003343", "lbl" : "septum transversum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme.", + "xrefs" : [ "GOC:dph", "PMID:18722343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003344", "lbl" : "pericardium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the pericardium is generated and organized.", + "xrefs" : [ "GOC:dph", "PMID:18722343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003348", "lbl" : "cardiac endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.", + "xrefs" : [ "GOC:dph", "PMID:18722343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003352", "lbl" : "regulation of cilium movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.", + "xrefs" : [ "GOC:dph" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003353", "lbl" : "positive regulation of cilium movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.", + "xrefs" : [ "GOC:dph" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003354", "lbl" : "negative regulation of cilium movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.", + "xrefs" : [ "GOC:dph" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003360", "lbl" : "brainstem development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003365", "lbl" : "establishment of cell polarity involved in ameboidal cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003371", "lbl" : "establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003379", "lbl" : "establishment of cell polarity involved in gastrulation cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003380", "lbl" : "establishment or maintenance of cytoskeleton polarity involved in gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003381", "lbl" : "epithelial cell morphogenesis involved in gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003382", "lbl" : "epithelial cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003403", "lbl" : "optic vesicle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003404", "lbl" : "optic vesicle morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003407", "lbl" : "neural retina development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003411", "lbl" : "cell motility involved in camera-type eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003413", "lbl" : "chondrocyte differentiation involved in endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003414", "lbl" : "chondrocyte morphogenesis involved in endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003416", "lbl" : "endochondral bone growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0003433", "lbl" : "chondrocyte development involved in endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003674", + "lbl" : "molecular_function", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.", + "xrefs" : [ "GOC:pdt" ] + }, + "comments" : [ "Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0003824", + "lbl" : "catalytic activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.", + "xrefs" : [ "GOC:vw", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Enzyme" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0004518", + "lbl" : "nuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of the hydrolysis of ester linkages within nucleic acids.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "comments" : [ "Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0004536", + "lbl" : "DNA nuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.", + "xrefs" : [ "GOC:mah", "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-211247" + }, { + "val" : "Reactome:R-HSA-5685994" + }, { + "val" : "Reactome:R-HSA-6785986" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005215", + "lbl" : "transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.", + "xrefs" : [ "GOC:ai", "GOC:dgf" ] + }, + "comments" : [ "Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005275", + "lbl" : "amine transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.", + "xrefs" : [ "GOC:mtg_transport", "ISBN:0198506732", "ISBN:0815340729" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005319", + "lbl" : "lipid transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the directed movement of lipids into, out of or within a cell, or between cells.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-1369028" + }, { + "val" : "Reactome:R-HSA-1369052" + }, { + "val" : "Reactome:R-HSA-174786" + }, { + "val" : "Reactome:R-HSA-5682285" + }, { + "val" : "Reactome:R-HSA-5682311" + }, { + "val" : "Reactome:R-HSA-5683672" + }, { + "val" : "Reactome:R-HSA-5683714" + }, { + "val" : "Reactome:R-HSA-5688397" + }, { + "val" : "Reactome:R-HSA-6801250" + }, { + "val" : "Reactome:R-HSA-8848053" + }, { + "val" : "Reactome:R-HSA-8866329" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005342", + "lbl" : "organic acid transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005355", + "lbl" : "glucose transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.", + "xrefs" : [ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-499981" + }, { + "val" : "Reactome:R-HSA-5653873" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005575", "lbl" : "cellular_component", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).", + "xrefs" : [ "GOC:pdt" ] + }, + "comments" : [ "Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1337158144" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005576", "lbl" : "extracellular region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'." ], + "xrefs" : [ { + "val" : "Wikipedia:Extracellular" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005577", "lbl" : "fibrinogen complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.", + "xrefs" : [ "ISBN:0198547684" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005581", "lbl" : "collagen trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.", + "xrefs" : [ "GOC:dos", "GOC:mah", "ISBN:0721639976", "PMID:19693541", "PMID:21421911" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Collagen" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005583", "lbl" : "fibrillar collagen trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any triple helical collagen trimer that forms fibrils.", + "xrefs" : [ "GOC:mah", "ISBN:0721639976", "PMID:21421911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005585", "lbl" : "collagen type II trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils.", + "xrefs" : [ "ISBN:0721639976" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Collagen_type_II" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005587", "lbl" : "collagen type IV trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.", + "xrefs" : [ "ISBN:0721639976", "PMID:19693541", "PMID:21421911" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Collagen_type_IV" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005604", "lbl" : "basement membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.", + "xrefs" : [ "ISBN:0198547684", "PMID:22505934" ] + }, + "comments" : [ "Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer." ], + "xrefs" : [ { + "val" : "Wikipedia:Basement_membrane" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005615", "lbl" : "extracellular space", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "comments" : [ "Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1425028079" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005622", "lbl" : "intracellular anatomical structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Intracellular" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005634", "lbl" : "nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1702920020" + }, { + "val" : "Wikipedia:Cell_nucleus" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005635", "lbl" : "nuclear envelope", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Nuclear_envelope" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005640", "lbl" : "nuclear outer membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1617136075" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005694", "lbl" : "chromosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "comments" : [ "Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore." ], + "xrefs" : [ { + "val" : "Wikipedia:Chromosome" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005730", "lbl" : "nucleolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1820400233" + }, { + "val" : "Wikipedia:Nucleolus" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005737", "lbl" : "cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cytoplasm" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005764", "lbl" : "lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao585356902" + }, { + "val" : "Wikipedia:Lysosome" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005765", "lbl" : "lysosomal membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005766", "lbl" : "primary lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lysosome before it has fused with a vesicle or vacuole.", + "xrefs" : [ "GOC:jl", "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1140587416" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005773", "lbl" : "vacuole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.", + "xrefs" : [ "GOC:mtg_sensu", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Vacuole" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005774", "lbl" : "vacuolar membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005775", "lbl" : "vacuolar lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The volume enclosed within the vacuolar membrane.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005794", "lbl" : "Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "comments" : [ "Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao451912436" + }, { + "val" : "Wikipedia:Golgi_apparatus" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005798", "lbl" : "Golgi-associated vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this definition includes vesicles that are transiently associated with the Golgi." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao819927218" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005840", "lbl" : "ribosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1429207766" + }, { + "val" : "Wikipedia:Ribosome" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005856", "lbl" : "cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.", + "xrefs" : [ "GOC:mah", "PMID:16959967", "PMID:27419875" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cytoskeleton" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005874", "lbl" : "microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.", + "xrefs" : [ "ISBN:0879693568" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1846835077" + }, { + "val" : "Wikipedia:Microtubule" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005879", "lbl" : "axonemal microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.", + "xrefs" : [ "GOC:cilia", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005880", "lbl" : "nuclear microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microtubule in the nucleus of a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005881", "lbl" : "cytoplasmic microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microtubule in the cytoplasm of a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005884", "lbl" : "actin filament", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732", "PMID:10666339" ] + }, + "xrefs" : [ { + "val" : "FMA:63850" + }, { + "val" : "NIF_Subcellular:sao1588493326" + }, { + "val" : "Wikipedia:Actin" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005886", "lbl" : "plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.", + "xrefs" : [ "ISBN:0716731363" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1663586795" + }, { + "val" : "Wikipedia:Cell_membrane" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005902", "lbl" : "microvillus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.", + "xrefs" : [ "ISBN:0815316194" ] + }, + "comments" : [ "Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao671419673" + }, { + "val" : "Wikipedia:Microvillus" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005911", "lbl" : "cell-cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "GOC:dgh", "GOC:hb", "GOC:mah", "PMID:21422226", "PMID:28096264" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1922892319" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005929", "lbl" : "cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.", + "xrefs" : [ "GOC:cilia", "GOC:curators", "GOC:kmv", "GOC:vw", "ISBN:0198547684", "PMID:16824949", "PMID:17009929", "PMID:20144998" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms." ], + "xrefs" : [ { + "val" : "FMA:67181" + }, { + "val" : "NIF_Subcellular:sao787716553" + }, { + "val" : "Wikipedia:Cilium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005930", "lbl" : "axoneme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.", + "xrefs" : [ "GOC:bf", "GOC:cilia", "ISBN:0198547684" ] + }, + "comments" : [ "Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane." ], + "xrefs" : [ { + "val" : "Wikipedia:Axoneme" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005938", "lbl" : "cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_cortex" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005975", "lbl" : "carbohydrate metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Carbohydrate_metabolism" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0005976", "lbl" : "polysaccharide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.", + "xrefs" : [ "ISBN:0198547684" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005977", + "lbl" : "glycogen metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005978", + "lbl" : "glycogen biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "MetaCyc:GLYCOGENSYNTH-PWY" + }, { + "val" : "MetaCyc:PWY-5067" + }, { + "val" : "MetaCyc:PWY-7900" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005979", + "lbl" : "regulation of glycogen biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005980", + "lbl" : "glycogen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "MetaCyc:GLYCOCAT-PWY" + }, { + "val" : "MetaCyc:PWY-5941" + }, { + "val" : "MetaCyc:PWY-7662" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0005981", + "lbl" : "regulation of glycogen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006006", + "lbl" : "glucose metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006007", + "lbl" : "glucose catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006024", "lbl" : "glycosaminoglycan biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.", + "xrefs" : [ "ISBN:0192800981" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006027", + "lbl" : "glycosaminoglycan catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars.", + "xrefs" : [ "ISBN:0192800981" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006082", + "lbl" : "organic acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006091", + "lbl" : "generation of precursor metabolites and energy", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006094", + "lbl" : "gluconeogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.", + "xrefs" : [ "MetaCyc:GLUCONEO-PWY" ] + }, + "xrefs" : [ { + "val" : "MetaCyc:GLUCONEO-PWY" + }, { + "val" : "Wikipedia:Gluconeogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006109", "lbl" : "regulation of carbohydrate metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006111", + "lbl" : "regulation of gluconeogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006112", + "lbl" : "energy reserve metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006139", "lbl" : "nucleobase-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006259", "lbl" : "DNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006308", + "lbl" : "DNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006309", + "lbl" : "apoptotic DNA fragmentation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:mtg_apoptosis", "GOC:tb", "ISBN:0721639976", "PMID:15723341", "PMID:23379520" ] + }, + "comments" : [ "DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006325", "lbl" : "chromatin organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.", + "xrefs" : [ "PMID:20404130" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006401", + "lbl" : "RNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006403", "lbl" : "RNA localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which RNA is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006412", "lbl" : "translation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Translation_(genetics)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006413", "lbl" : "translational initiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.", + "xrefs" : [ "ISBN:019879276X" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006414", "lbl" : "translational elongation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.", + "xrefs" : [ "GOC:ems" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006415", "lbl" : "translational termination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).", + "xrefs" : [ "GOC:hjd", "ISBN:019879276X" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006417", "lbl" : "regulation of translation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006446", "lbl" : "regulation of translational initiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of translational initiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006448", "lbl" : "regulation of translational elongation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, extent or accuracy of translational elongation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006449", "lbl" : "regulation of translational termination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of translational termination.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006516", + "lbl" : "glycoprotein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006518", "lbl" : "peptide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006576", "lbl" : "biogenic amine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.", + "xrefs" : [ "GOC:jl", "ISBN:0395825172" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006584", "lbl" : "catecholamine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006629", "lbl" : "lipid metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.", + "xrefs" : [ "GOC:ma" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Lipid_metabolism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006694", + "lbl" : "steroid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Steroid_metabolisms#Steroid_biosynthesis" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006699", + "lbl" : "bile acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006706", + "lbl" : "steroid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006810", "lbl" : "transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.", + "xrefs" : [ "GOC:dos", "GOC:dph", "GOC:jl", "GOC:mah" ] + }, + "comments" : [ "Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006811", "lbl" : "monoatomic ion transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006837", "lbl" : "serotonin transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006858", "lbl" : "extracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The transport of substances that occurs outside cells.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006869", "lbl" : "lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0006873", + "lbl" : "intracellular monoatomic ion homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006886", "lbl" : "intracellular protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006887", "lbl" : "exocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.", + "xrefs" : [ "GOC:mah", "ISBN:0716731363", "PMID:22323285" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Exocytosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006892", "lbl" : "post-Golgi vesicle-mediated transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.", + "xrefs" : [ "GOC:ai", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006893", "lbl" : "Golgi to plasma membrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.", + "xrefs" : [ "ISBN:0716731363" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006896", "lbl" : "Golgi to vacuole transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances from the Golgi to the vacuole.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006897", "lbl" : "endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732", "ISBN:0716731363", "Wikipedia:Endocytosis" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Endocytosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006900", "lbl" : "vesicle budding from membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The evagination of a membrane, resulting in formation of a vesicle.", + "xrefs" : [ "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006903", "lbl" : "vesicle targeting", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.", + "xrefs" : [ "GOC:mah", "PMID:17335816" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006906", "lbl" : "vesicle fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fusion of the membrane of a transport vesicle with its target membrane.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006909", "lbl" : "phagocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Phagocytosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006915", "lbl" : "apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.", + "xrefs" : [ "GOC:cjm", "GOC:dhl", "GOC:ecd", "GOC:go_curators", "GOC:mtg_apoptosis", "GOC:tb", "ISBN:0198506732", "PMID:18846107", "PMID:21494263" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Apoptosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006921", "lbl" : "cellular component disassembly involved in execution phase of apoptosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006925", "lbl" : "inflammatory cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage.", + "xrefs" : [ "GOC:jl", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006935", "lbl" : "chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Chemotaxis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006936", "lbl" : "muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.", + "xrefs" : [ "GOC:ef", "GOC:mtg_muscle", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Muscle_contraction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006937", "lbl" : "regulation of muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006939", "lbl" : "smooth muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.", + "xrefs" : [ "GOC:ef", "GOC:jl", "GOC:mtg_muscle", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006940", "lbl" : "regulation of smooth muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006941", "lbl" : "striated muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.", + "xrefs" : [ "GOC:jl", "GOC:mtg_muscle", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006942", "lbl" : "regulation of striated muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of striated muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006949", "lbl" : "syncytium formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006950", "lbl" : "response to stress", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006952", "lbl" : "defense response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006954", "lbl" : "inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.", + "xrefs" : [ "GO_REF:0000022", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Inflammation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006955", "lbl" : "immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.", + "xrefs" : [ "GOC:add", "GO_REF:0000022" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006996", "lbl" : "organelle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006997", "lbl" : "nucleus organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0006998", "lbl" : "nuclear envelope organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007000", "lbl" : "nucleolus organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007009", "lbl" : "plasma membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007010", "lbl" : "cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007015", "lbl" : "actin filament organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007017", "lbl" : "microtubule-based process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007018", "lbl" : "microtubule-based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.", + "xrefs" : [ "GOC:cjm", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007019", "lbl" : "microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The removal of tubulin heterodimers from one or both ends of a microtubule.", + "xrefs" : [ "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007020", "lbl" : "microtubule nucleation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).", + "xrefs" : [ "GOC:go_curators", "ISBN:0815316194", "PMID:12517712" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Microtubule_nucleation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007026", "lbl" : "negative regulation of microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007027", "lbl" : "negative regulation of axonemal microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme.", + "xrefs" : [ "GOC:dph", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007028", "lbl" : "cytoplasm organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.", + "xrefs" : [ "GOC:curators", "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007030", "lbl" : "Golgi organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007033", "lbl" : "vacuole organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007034", "lbl" : "vacuolar transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances into, out of or within a vacuole.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007039", + "lbl" : "protein catabolic process in the vacuole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases.", + "xrefs" : [ "GOC:mah", "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007040", "lbl" : "lysosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007041", "lbl" : "lysosomal transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances into, out of or within a lysosome.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007043", "lbl" : "cell-cell junction assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a junction between cells.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007049", "lbl" : "cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_cell_cycle" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_cycle" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007059", "lbl" : "chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.", + "xrefs" : [ "GOC:jl", "GOC:mah", "GOC:mtg_cell_cycle", "GOC:vw" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Chromosome_segregation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007076", "lbl" : "mitotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007077", "lbl" : "mitotic nuclear membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis.", + "xrefs" : [ "GOC:bf", "PMID:32848252" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007088", "lbl" : "regulation of mitotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mitosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007097", "lbl" : "nuclear migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of the nucleus to a specific location within a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007113", "lbl" : "endomitotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.", + "xrefs" : [ "GOC:curators", "GOC:dos", "GOC:expert_vm" ] + }, + "comments" : [ "Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins." ], + "xrefs" : [ { + "val" : "Wikipedia:Mitosis#Endomitosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007143", "lbl" : "female meiotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:mah", "GOC:vw" ] + }, + "comments" : [ "Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007154", "lbl" : "cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_signaling" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007155", "lbl" : "cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.", + "xrefs" : [ "GOC:hb", "GOC:pf" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_adhesion" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007159", "lbl" : "leukocyte cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The attachment of a leukocyte to another cell via adhesion molecules.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007162", "lbl" : "negative regulation of cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007163", "lbl" : "establishment or maintenance of cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007165", "lbl" : "signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_signaling_feb11" ] + }, + "comments" : [ "Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not." ], + "xrefs" : [ { + "val" : "Wikipedia:Signal_transduction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007267", "lbl" : "cell-cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.", + "xrefs" : [ "GOC:dos", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007268", "lbl" : "chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.", + "xrefs" : [ "GOC:jl", "MeSH:D009435" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Neurotransmission" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007275", "lbl" : "multicellular organism development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:isa_complete", "GOC:tb" ] + }, + "comments" : [ "Note that this term was 'developmental process'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007276", "lbl" : "gamete generation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.", + "xrefs" : [ "GOC:ems", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007281", "lbl" : "germ cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007292", "lbl" : "female gamete generation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.", + "xrefs" : [ "GOC:dph", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007293", "lbl" : "germarium-derived egg chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:mtg_sensu", "ISBN:0879694238" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007308", "lbl" : "oocyte construction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:mtg_sensu", "GOC:tb", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007338", "lbl" : "single fertilization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The union of male and female gametes to form a zygote.", + "xrefs" : [ "GOC:ems", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007343", "lbl" : "egg activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm.", + "xrefs" : [ "GOC:bf", "PMID:9630751" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Egg_activation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007346", "lbl" : "regulation of mitotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of progress through the mitotic cell cycle.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007350", "lbl" : "blastoderm segmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.", + "xrefs" : [ "ISBN:0879694238", "http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007369", "lbl" : "gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.", + "xrefs" : [ "GOC:curators", "ISBN:9780878933846" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Gastrulation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007389", "lbl" : "pattern specification process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.", + "xrefs" : [ "GOC:go_curators", "GOC:isa_complete", "ISBN:0521436125" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007398", "lbl" : "ectoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007399", "lbl" : "nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007405", "lbl" : "neuroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.", + "xrefs" : [ "GOC:ai", "GOC:mtg_sensu", "GOC:sart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007406", "lbl" : "negative regulation of neuroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007407", "lbl" : "neuroblast activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007416", "lbl" : "synapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Synaptogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007417", "lbl" : "central nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.", + "xrefs" : [ "GOC:bf", "GOC:jid", "ISBN:0582227089" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Neural_development" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007420", "lbl" : "brain development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb", "UBERON:0000955" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007422", "lbl" : "peripheral nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.", + "xrefs" : [ "GOC:go_curators", "UBERON:0000010" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007423", "lbl" : "sensory organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007439", "lbl" : "ectodermal digestive tract development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007440", "lbl" : "foregut morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the foregut are generated and organized.", + "xrefs" : [ "GOC:jid" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007442", + "lbl" : "hindgut morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the hindgut are generated and organized.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007492", "lbl" : "endoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007494", + "lbl" : "midgut development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.", + "xrefs" : [ "GOC:jid", "UBERON:0001045" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007498", "lbl" : "mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007506", "lbl" : "gonadal mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007507", "lbl" : "heart development", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7227" + "definition" : { + "val" : "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.", + "xrefs" : [ "GOC:jid", "UBERON:0000948" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Heart_development" } ] } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007517", "lbl" : "muscle organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.", + "xrefs" : [ "GOC:jid", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007519", "lbl" : "skeletal muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007528", "lbl" : "neuromuscular junction development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.", + "xrefs" : [ "GOC:mtg_OBO2OWL_2013" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007548", "lbl" : "sex differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The establishment of the sex of an organism by physical differentiation.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Sexual_differentiation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007565", "lbl" : "female pregnancy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.", + "xrefs" : [ "ISBN:0192800825" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Gestation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007566", "lbl" : "embryo implantation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Attachment of the blastocyst to the uterine lining.", + "xrefs" : [ "GOC:isa_complete", "PMID:10882512" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007585", "lbl" : "respiratory gaseous exchange by respiratory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007586", "lbl" : "digestion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:isa_complete", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Digestion" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007588", + "lbl" : "excretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.", + "xrefs" : [ "ISBN:0192801023" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Excretion" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007589", + "lbl" : "body fluid secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of a fluid by a cell or tissue in an animal.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007600", "lbl" : "sensory perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.", + "xrefs" : [ "GOC:ai", "GOC:dph" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Perception" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007601", "lbl" : "visual perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Visual_perception" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007605", "lbl" : "sensory perception of sound", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Hearing_(sense)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0007606", "lbl" : "sensory perception of chemical stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007610", + "lbl" : "behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.", + "xrefs" : [ "GOC:ems", "GOC:jl", "ISBN:0395448956", "PMID:20160973" ] + }, + "comments" : [ "1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis)." ], + "xrefs" : [ { + "val" : "Wikipedia:Behavior" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0007626", + "lbl" : "locomotory behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008015", "lbl" : "blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.", + "xrefs" : [ "GOC:mtg_heart", "ISBN:0192800825" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008016", "lbl" : "regulation of heart contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008078", "lbl" : "mesodermal cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of mesodermal cells from one site to another.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:mah", "GOC:sat", "GOC:tb", "PMID:25119047" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008088", "lbl" : "axo-dendritic transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of organelles or molecules along microtubules in neuron projections.", + "xrefs" : [ "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Axoplasmic_transport" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008104", "lbl" : "protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008150", "lbl" : "biological_process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.", + "xrefs" : [ "GOC:pdt" ] + }, + "comments" : [ "Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this." ], + "xrefs" : [ { + "val" : "Wikipedia:Biological_process" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008152", "lbl" : "metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198547684" ] + }, + "comments" : [ "Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions." ], + "xrefs" : [ { + "val" : "Wikipedia:Metabolism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0008202", + "lbl" : "steroid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Steroid_metabolism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0008206", + "lbl" : "bile acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008219", "lbl" : "cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis", "PMID:25236395" ] + }, + "comments" : [ "This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008283", "lbl" : "cell population proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population.", + "xrefs" : [ "GOC:mah", "GOC:mb" ] + }, + "comments" : [ "This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008284", "lbl" : "positive regulation of cell population proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of cell proliferation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008285", "lbl" : "negative regulation of cell population proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of cell proliferation.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0008320", + "lbl" : "protein transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a protein from one side of a membrane to the other.", + "xrefs" : [ "GOC:jl" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-1268022" + }, { + "val" : "Reactome:R-HSA-1299475" + }, { + "val" : "Reactome:R-HSA-184269" + }, { + "val" : "Reactome:R-HSA-3149434" + }, { + "val" : "Reactome:R-HSA-5205661" + }, { + "val" : "Reactome:R-HSA-5210943" + }, { + "val" : "Reactome:R-HSA-5210947" + }, { + "val" : "Reactome:R-HSA-5228406" + }, { + "val" : "Reactome:R-HSA-5229111" + }, { + "val" : "Reactome:R-HSA-5244404" + }, { + "val" : "Reactome:R-HSA-5244428" + }, { + "val" : "Reactome:R-HSA-5244506" + }, { + "val" : "Reactome:R-HSA-5246514" + }, { + "val" : "Reactome:R-HSA-5250616" + }, { + "val" : "Reactome:R-HSA-5250884" + }, { + "val" : "Reactome:R-HSA-5250972" + }, { + "val" : "Reactome:R-HSA-5336420" + }, { + "val" : "Reactome:R-HSA-9636375" + }, { + "val" : "Reactome:R-HSA-9698930" + }, { + "val" : "Reactome:R-HSA-9698933" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008347", "lbl" : "glial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.", + "xrefs" : [ "GOC:jl", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008354", "lbl" : "germ cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.", + "xrefs" : [ "GOC:bf", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008356", "lbl" : "asymmetric cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.", + "xrefs" : [ "PMID:11672519" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Asymmetric_cell_division" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008406", "lbl" : "gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.", + "xrefs" : [ "GOC:ems", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008544", "lbl" : "epidermis development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.", + "xrefs" : [ "GOC:go_curators", "UBERON:0001003" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008585", "lbl" : "female gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008594", "lbl" : "photoreceptor cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:jid", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008610", "lbl" : "lipid biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0008643", "lbl" : "carbohydrate transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0008645", + "lbl" : "hexose transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule.", + "xrefs" : [ "GOC:vw" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009056", + "lbl" : "catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Catabolism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009057", + "lbl" : "macromolecule catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009058", "lbl" : "biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.", + "xrefs" : [ "GOC:curators", "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Anabolism" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009059", "lbl" : "macromolecule biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009100", "lbl" : "glycoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009101", "lbl" : "glycoprotein biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009250", + "lbl" : "glucan biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009251", + "lbl" : "glucan catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009306", "lbl" : "protein secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of proteins from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009308", "lbl" : "amine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009309", "lbl" : "amine biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009310", + "lbl" : "amine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009314", "lbl" : "response to radiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.", + "xrefs" : [ "GOC:jl", "Wikipedia:Electromagnetic_radiation" ] + }, + "comments" : [ "Note that 'radiation' refers to electromagnetic radiation of any wavelength." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009416", "lbl" : "response to light stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.", + "xrefs" : [ "GOC:go_curators", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009566", "lbl" : "fertilization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).", + "xrefs" : [ "GOC:tb", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Fertilisation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009581", "lbl" : "detection of external stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which an external stimulus is received by a cell and converted into a molecular signal.", + "xrefs" : [ "GOC:hb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009582", "lbl" : "detection of abiotic stimulus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0009583", - "lbl" : "detection of light stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.", + "xrefs" : [ "GOC:hb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009583", + "lbl" : "detection of light stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009584", "lbl" : "detection of visible light", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009593", "lbl" : "detection of chemical stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009605", "lbl" : "response to external stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.", + "xrefs" : [ "GOC:hb" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009607", "lbl" : "response to biotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.", + "xrefs" : [ "GOC:hb" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009617", "lbl" : "response to bacterium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.", + "xrefs" : [ "GOC:hb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009620", "lbl" : "response to fungus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.", + "xrefs" : [ "GOC:hb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009628", "lbl" : "response to abiotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.", + "xrefs" : [ "GOC:hb" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009636", + "lbl" : "response to toxic substance", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.", + "xrefs" : [ "GOC:lr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009653", "lbl" : "anatomical structure morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.", + "xrefs" : [ "GOC:go_curators", "ISBN:0521436125" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Morphogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009712", "lbl" : "catechol-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent.", + "xrefs" : [ "GOC:sm", "ISBN:0198547684" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009713", "lbl" : "catechol-containing compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009719", "lbl" : "response to endogenous stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.", + "xrefs" : [ "GOC:sm" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009725", "lbl" : "response to hormone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009743", "lbl" : "response to carbohydrate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009746", + "lbl" : "response to hexose", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009749", + "lbl" : "response to glucose", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009786", "lbl" : "regulation of asymmetric cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of asymmetric cell division.", + "xrefs" : [ "GOC:lr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009790", "lbl" : "embryo development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.", + "xrefs" : [ "GOC:go_curators", "GOC:isa_complete", "GOC:mtg_sensu" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Embryogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009791", "lbl" : "post-embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009792", "lbl" : "embryo development ending in birth or egg hatching", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.", + "xrefs" : [ "GOC:go_curators", "GOC:isa_complete", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009880", "lbl" : "embryonic pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that results in the patterns of cell differentiation that will arise in an embryo.", + "xrefs" : [ "GOC:go_curators", "ISBN:0521436125" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009887", "lbl" : "animal organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:dgh", "GOC:go_curators", "ISBN:0471245208", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009888", "lbl" : "tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.", + "xrefs" : [ "ISBN:0471245208" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Histogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009889", "lbl" : "regulation of biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009890", "lbl" : "negative regulation of biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009891", "lbl" : "positive regulation of biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009892", "lbl" : "negative regulation of metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009893", "lbl" : "positive regulation of metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009894", + "lbl" : "regulation of catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009895", + "lbl" : "negative regulation of catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0009896", + "lbl" : "positive regulation of catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009913", "lbl" : "epidermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:mtg_sensu", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009914", "lbl" : "hormone transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009952", "lbl" : "anterior/posterior pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:isa_complete", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009966", "lbl" : "regulation of signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of signal transduction.", + "xrefs" : [ "GOC:sm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009967", "lbl" : "positive regulation of signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of signal transduction.", + "xrefs" : [ "GOC:sm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009968", "lbl" : "negative regulation of signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.", + "xrefs" : [ "GOC:sm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009987", "lbl" : "cellular process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.", + "xrefs" : [ "GOC:go_curators", "GOC:isa_complete" ] + }, + "comments" : [ "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0009994", "lbl" : "oocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010001", "lbl" : "glial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010002", "lbl" : "cardioblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010032", "lbl" : "meiotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Compaction of chromatin structure prior to meiosis in eukaryotic cells.", + "xrefs" : [ "PMID:10072401" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010070", "lbl" : "zygote asymmetric cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010160", "lbl" : "formation of animal organ boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "PMID:9611175" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010171", "lbl" : "body morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the soma are generated and organized.", + "xrefs" : [ "GOC:ems", "ISBN:0140512888" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010243", "lbl" : "response to organonitrogen compound", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.", + "xrefs" : [ "PMID:9869419" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010256", "lbl" : "endomembrane system organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.", + "xrefs" : [ "GOC:mah", "GOC:sm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010324", "lbl" : "membrane invagination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The infolding of a membrane.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010453", "lbl" : "regulation of cell fate commitment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010454", "lbl" : "negative regulation of cell fate commitment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010455", "lbl" : "positive regulation of cell fate commitment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010463", "lbl" : "mesenchymal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010464", "lbl" : "regulation of mesenchymal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010467", "lbl" : "gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes.", + "xrefs" : [ "GOC:txnOH-2018", "PMID:25934543", "PMID:31580950" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Gene_expression" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010468", "lbl" : "regulation of gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).", + "xrefs" : [ "GOC:txnOH-2018" ] + }, + "comments" : [ "This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation." ], + "xrefs" : [ { + "val" : "Wikipedia:Regulation_of_gene_expression" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010470", "lbl" : "regulation of gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010481", "lbl" : "epidermal cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells.", + "xrefs" : [ "PMID:17450124" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010482", "lbl" : "regulation of epidermal cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis.", + "xrefs" : [ "PMID:17450124" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010496", "lbl" : "intercellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of substances between cells.", + "xrefs" : [ "GOC:dhl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010549", "lbl" : "regulation of membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of membrane disassembly.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010556", "lbl" : "regulation of macromolecule biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010557", "lbl" : "positive regulation of macromolecule biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010558", "lbl" : "negative regulation of macromolecule biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010559", "lbl" : "regulation of glycoprotein biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010560", "lbl" : "positive regulation of glycoprotein biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010561", "lbl" : "negative regulation of glycoprotein biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010564", "lbl" : "regulation of cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010565", + "lbl" : "regulation of cellular ketone metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010566", + "lbl" : "regulation of ketone biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010567", + "lbl" : "regulation of ketone catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010594", "lbl" : "regulation of endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010595", "lbl" : "positive regulation of endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010596", "lbl" : "negative regulation of endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010604", "lbl" : "positive regulation of macromolecule metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010605", "lbl" : "negative regulation of macromolecule metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010608", "lbl" : "post-transcriptional regulation of gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010611", "lbl" : "regulation of cardiac muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010612", "lbl" : "regulation of cardiac muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010613", "lbl" : "positive regulation of cardiac muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010614", "lbl" : "negative regulation of cardiac muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010615", "lbl" : "positive regulation of cardiac muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010616", "lbl" : "negative regulation of cardiac muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010623", "lbl" : "programmed cell death involved in cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The activation of endogenous cellular processes that result in the death of a cell as part of its development.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + }, + "comments" : [ "This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010628", "lbl" : "positive regulation of gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).", + "xrefs" : [ "GOC:txnOH-2018" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010629", "lbl" : "negative regulation of gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).", + "xrefs" : [ "GOC:txnOH-2018" ] + }, + "comments" : [ "This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010631", "lbl" : "epithelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "GOC:BHF", "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010632", "lbl" : "regulation of epithelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010633", "lbl" : "negative regulation of epithelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010634", "lbl" : "positive regulation of epithelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epithelial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010638", "lbl" : "positive regulation of organelle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010639", "lbl" : "negative regulation of organelle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010646", "lbl" : "regulation of cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010647", "lbl" : "positive regulation of cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010648", "lbl" : "negative regulation of cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010656", "lbl" : "negative regulation of muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010657", "lbl" : "muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle.", + "xrefs" : [ "CL:0000187", "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010658", "lbl" : "striated muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations.", + "xrefs" : [ "CL:0000737", "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010659", "lbl" : "cardiac muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.", + "xrefs" : [ "CL:0000746", "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010660", "lbl" : "regulation of muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010661", "lbl" : "positive regulation of muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010662", "lbl" : "regulation of striated muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010663", "lbl" : "positive regulation of striated muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010664", "lbl" : "negative regulation of striated muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:mtg_apoptosis", "GOC:rl", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010665", "lbl" : "regulation of cardiac muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010666", "lbl" : "positive regulation of cardiac muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010667", "lbl" : "negative regulation of cardiac muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:mtg_apoptosis", "GOC:rl", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010668", "lbl" : "ectodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010700", "lbl" : "negative regulation of norepinephrine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010701", "lbl" : "positive regulation of norepinephrine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010710", + "lbl" : "regulation of collagen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010711", + "lbl" : "negative regulation of collagen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010712", "lbl" : "regulation of collagen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010713", "lbl" : "negative regulation of collagen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010714", "lbl" : "positive regulation of collagen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010715", "lbl" : "regulation of extracellular matrix disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010716", "lbl" : "negative regulation of extracellular matrix disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010717", "lbl" : "regulation of epithelial to mesenchymal transition", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010718", "lbl" : "positive regulation of epithelial to mesenchymal transition", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010719", "lbl" : "negative regulation of epithelial to mesenchymal transition", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010720", "lbl" : "positive regulation of cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010721", "lbl" : "negative regulation of cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010758", "lbl" : "regulation of macrophage chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010759", "lbl" : "positive regulation of macrophage chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010760", "lbl" : "negative regulation of macrophage chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010761", "lbl" : "fibroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010762", "lbl" : "regulation of fibroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010763", "lbl" : "positive regulation of fibroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010764", "lbl" : "negative regulation of fibroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010770", "lbl" : "positive regulation of cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010771", "lbl" : "negative regulation of cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010817", "lbl" : "regulation of hormone levels", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010818", "lbl" : "T cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010819", "lbl" : "regulation of T cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010820", "lbl" : "positive regulation of T cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010827", + "lbl" : "regulation of glucose transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010828", + "lbl" : "positive regulation of glucose transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010829", + "lbl" : "negative regulation of glucose transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010830", "lbl" : "regulation of myotube differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010831", "lbl" : "positive regulation of myotube differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010832", "lbl" : "negative regulation of myotube differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010842", "lbl" : "retina layer formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb", "PMID:1270266" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010876", "lbl" : "lipid localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a lipid is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010893", + "lbl" : "positive regulation of steroid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.", + "xrefs" : [ "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010894", + "lbl" : "negative regulation of steroid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.", + "xrefs" : [ "GOC:BHF", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010906", + "lbl" : "regulation of glucose metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.", + "xrefs" : [ "GOC:BHF", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010907", + "lbl" : "positive regulation of glucose metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.", + "xrefs" : [ "GOC:BHF", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010927", "lbl" : "cellular component assembly involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular component assembly that is part of the initial shaping of the component during its developmental progression.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010934", "lbl" : "macrophage cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:rl", "GOC:tb" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010935", "lbl" : "regulation of macrophage cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010936", "lbl" : "negative regulation of macrophage cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010937", "lbl" : "regulation of cytoplasmic microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010938", "lbl" : "cytoplasmic microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010948", "lbl" : "negative regulation of cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0010962", + "lbl" : "regulation of glucan biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010968", "lbl" : "regulation of microtubule nucleation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010970", "lbl" : "transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010975", "lbl" : "regulation of neuron projection development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010976", "lbl" : "positive regulation of neuron projection development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0010977", "lbl" : "negative regulation of neuron projection development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0012501", "lbl" : "programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.", + "xrefs" : [ "GOC:lr", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children." ], + "xrefs" : [ { + "val" : "Wikipedia:Programmed_cell_death" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0012505", "lbl" : "endomembrane system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.", + "xrefs" : [ "GOC:lh" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Endomembrane_system" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0012506", "lbl" : "vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding any membrane-bounded vesicle in the cell.", + "xrefs" : [ "GOC:mah", "GOC:vesicle" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1153182838" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014009", "lbl" : "glial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.", + "xrefs" : [ "GOC:ef", "ISBN:0878932585" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014013", "lbl" : "regulation of gliogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014014", "lbl" : "negative regulation of gliogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014015", "lbl" : "positive regulation of gliogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014016", "lbl" : "neuroblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts.", + "xrefs" : [ "GOC:ef", "ISBN:0878932585" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014019", "lbl" : "neuroblast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron.", + "xrefs" : [ "GOC:ef", "ISBN:0878932585" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014020", "lbl" : "primary neural tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.", + "xrefs" : [ "GOC:ef", "ISBN:0878932585", "PMID:15327780" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014023", "lbl" : "neural rod formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014025", "lbl" : "neural keel formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014028", "lbl" : "notochord formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014029", "lbl" : "neural crest formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014031", "lbl" : "mesenchymal cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014032", "lbl" : "neural crest cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014033", "lbl" : "neural crest cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.", + "xrefs" : [ "GOC:dh", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014041", "lbl" : "regulation of neuron maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014042", "lbl" : "positive regulation of neuron maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuron maturation.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014043", "lbl" : "negative regulation of neuron maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014061", "lbl" : "regulation of norepinephrine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014062", "lbl" : "regulation of serotonin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of serotonin.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014063", "lbl" : "negative regulation of serotonin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014064", "lbl" : "positive regulation of serotonin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014075", "lbl" : "response to amine", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.", + "xrefs" : [ "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014706", "lbl" : "striated muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.", + "xrefs" : [ "CL:0000737", "GOC:dph", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014733", "lbl" : "regulation of skeletal muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014734", "lbl" : "skeletal muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014741", "lbl" : "negative regulation of muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014742", "lbl" : "positive regulation of muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014743", "lbl" : "regulation of muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle hypertrophy.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014744", "lbl" : "positive regulation of muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of muscle adaptation.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014745", "lbl" : "negative regulation of muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014805", "lbl" : "smooth muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014807", "lbl" : "regulation of somitogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of somitogenesis.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014812", "lbl" : "muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "CL:0000187", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014819", "lbl" : "regulation of skeletal muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle contraction.", + "xrefs" : [ "GOC:ef", "GOC:mtg_muscle" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0014821", + "lbl" : "phasic smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0014827", + "lbl" : "intestine smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine.", + "xrefs" : [ "GOC:mtg_muscle", "MA:0001539", "MSH:D007422" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0014831", + "lbl" : "gastro-intestinal system smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract).", + "xrefs" : [ "GOC:mtg_muscle", "MA:0001523", "MSH:D041981" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014855", "lbl" : "striated muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.", + "xrefs" : [ "CL:0000737", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014856", "lbl" : "skeletal muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population.", + "xrefs" : [ "CL:0000188", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014857", "lbl" : "regulation of skeletal muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation.", + "xrefs" : [ "CL:0000188", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014858", "lbl" : "positive regulation of skeletal muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation.", + "xrefs" : [ "CL:0000188", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014859", "lbl" : "negative regulation of skeletal muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation.", + "xrefs" : [ "CL:0000188", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014861", "lbl" : "regulation of skeletal muscle contraction via regulation of action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014866", "lbl" : "skeletal myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.", + "xrefs" : [ "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014872", "lbl" : "myoblast division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014874", "lbl" : "response to stimulus involved in regulation of muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation.", + "xrefs" : [ "GOC:ef", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014887", "lbl" : "cardiac muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014888", "lbl" : "striated muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014895", "lbl" : "smooth muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014896", "lbl" : "muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy.", + "xrefs" : [ "GOC:mtg_muscle" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Muscle_hypertrophy" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014897", "lbl" : "striated muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014902", "lbl" : "myotube differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014904", "lbl" : "myotube cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.", + "xrefs" : [ "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014909", "lbl" : "smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "CL:0000192", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014910", "lbl" : "regulation of smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle cell migration.", + "xrefs" : [ "CL:0000192", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014911", "lbl" : "positive regulation of smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.", + "xrefs" : [ "CL:0000192", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0014912", "lbl" : "negative regulation of smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.", + "xrefs" : [ "CL:0000192", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015031", "lbl" : "protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015075", + "lbl" : "monoatomic ion transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of an ion from one side of a membrane to the other.", + "xrefs" : [ "GOC:dgf", "GOC:mtg_transport", "ISBN:0815340729" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015106", + "lbl" : "bicarbonate transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "RHEA:28695" + }, { + "val" : "Reactome:R-HSA-2752067" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015125", + "lbl" : "bile acid transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-194079" + }, { + "val" : "Reactome:R-HSA-194083" + }, { + "val" : "Reactome:R-HSA-194130" + }, { + "val" : "Reactome:R-HSA-5661184" + }, { + "val" : "Reactome:R-HSA-5661198" + }, { + "val" : "Reactome:R-HSA-9733964" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015144", + "lbl" : "carbohydrate transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of carbohydrate from one side of a membrane to the other.", + "xrefs" : [ "GOC:jl", "GOC:mtg_transport", "ISBN:0815340729" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015149", + "lbl" : "hexose transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other.", + "xrefs" : [ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-189242" + }, { + "val" : "Reactome:R-HSA-5638222" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015159", + "lbl" : "polysaccharide transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.", + "xrefs" : [ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015629", "lbl" : "actin cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.", + "xrefs" : [ "GOC:jl", "ISBN:0395825172", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015630", "lbl" : "microtubule cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.", + "xrefs" : [ "GOC:jl", "ISBN:0395825172" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015669", "lbl" : "gas transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015671", "lbl" : "oxygen transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015701", + "lbl" : "bicarbonate transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:krc" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015718", + "lbl" : "monocarboxylic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:krc" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015721", + "lbl" : "bile acid and bile salt transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:dph", "GOC:krc", "PMID:12663868", "PMID:14699511" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015774", "lbl" : "polysaccharide transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015833", "lbl" : "peptide transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015837", "lbl" : "amine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015849", + "lbl" : "organic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015850", "lbl" : "organic hydroxy compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015869", "lbl" : "protein-DNA complex transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015874", "lbl" : "norepinephrine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.", + "xrefs" : [ "GOC:ai", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0015931", "lbl" : "nucleobase-containing compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015932", + "lbl" : "nucleobase-containing compound transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0015980", + "lbl" : "energy derivation by oxidation of organic compounds", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016020", "lbl" : "membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.", + "xrefs" : [ "GOC:dos", "GOC:mah", "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Biological_membrane" + }, { + "val" : "Wikipedia:Transmembrane_protein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016042", + "lbl" : "lipid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Lipid_catabolism" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016043", "lbl" : "cellular component organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.", + "xrefs" : [ "GOC:ai", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016049", "lbl" : "cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016050", "lbl" : "vesicle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016051", "lbl" : "carbohydrate biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016052", + "lbl" : "carbohydrate catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016053", + "lbl" : "organic acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016054", + "lbl" : "organic acid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016057", "lbl" : "regulation of membrane potential in photoreceptor cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon.", + "xrefs" : [ "GOC:dph", "GOC:hb", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016070", "lbl" : "RNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016192", "lbl" : "vesicle-mediated transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.", + "xrefs" : [ "GOC:ai", "GOC:mah", "ISBN:08789310662000" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016202", "lbl" : "regulation of striated muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of striated muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016321", "lbl" : "female meiosis chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016325", "lbl" : "oocyte microtubule cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:mtg_sensu", "PMID:11231123" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016331", "lbl" : "morphogenesis of embryonic epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of embryonic epithelia are generated and organized.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016477", "lbl" : "cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.", + "xrefs" : [ "GOC:cjm", "GOC:dph", "GOC:ems", "GOC:pf", "Wikipedia:Cell_migration" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_migration" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016525", "lbl" : "negative regulation of angiogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0016528", "lbl" : "sarcoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.", + "xrefs" : [ "ISBN:0198547684" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Sarcoplasm" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016787", + "lbl" : "hydrolase activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "EC:3.-.-.-" + }, { + "val" : "Reactome:R-HSA-1236938" + }, { + "val" : "Reactome:R-HSA-2029475" + }, { + "val" : "Reactome:R-HSA-5694583" + }, { + "val" : "Reactome:R-HSA-5695964" + }, { + "val" : "Reactome:R-HSA-6786190" + }, { + "val" : "Reactome:R-HSA-6788295" + }, { + "val" : "Reactome:R-HSA-8938314" + }, { + "val" : "Reactome:R-HSA-8952137" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0016788", + "lbl" : "hydrolase activity, acting on ester bonds", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of the hydrolysis of any ester bond.", + "xrefs" : [ "GOC:jl" ] + }, + "xrefs" : [ { + "val" : "EC:3.1.-.-" + }, { + "val" : "Reactome:R-HSA-162729" + }, { + "val" : "Reactome:R-HSA-9023617" + }, { + "val" : "Reactome:R-HSA-9023619" + }, { + "val" : "Reactome:R-HSA-9749609" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0017126", "lbl" : "nucleologenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0017145", "lbl" : "stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.", + "xrefs" : [ "GOC:jid", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0017148", "lbl" : "negative regulation of translation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0017157", "lbl" : "regulation of exocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of exocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0018958", "lbl" : "phenol-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "comments" : [ "Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds." ], + "xrefs" : [ { + "val" : "UM-BBD_pathwayID:phe" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019098", + "lbl" : "reproductive behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specific behavior of an organism that is associated with reproduction.", + "xrefs" : [ "GOC:jl", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019216", "lbl" : "regulation of lipid metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019218", + "lbl" : "regulation of steroid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019219", "lbl" : "regulation of nucleobase-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019222", "lbl" : "regulation of metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019226", "lbl" : "transmission of nerve impulse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.", + "xrefs" : [ "GOC:curators", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019228", "lbl" : "neuronal action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An action potential that occurs in a neuron.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019233", "lbl" : "sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.", + "xrefs" : [ "GOC:curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Nociception" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019318", + "lbl" : "hexose metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019319", + "lbl" : "hexose biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019320", + "lbl" : "hexose catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019336", + "lbl" : "phenol-containing compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "MetaCyc:PHENOLDEG-PWY" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019538", "lbl" : "protein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving a protein. Includes protein modification.", + "xrefs" : [ "GOC:ma" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ], + "xrefs" : [ { + "val" : "Wikipedia:Protein_metabolism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019614", + "lbl" : "catechol-containing compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019725", "lbl" : "cellular homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of an internal steady state at the level of the cell.", + "xrefs" : [ "GOC:isa_complete", "GOC:jl", "ISBN:0395825172" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0019752", + "lbl" : "carboxylic acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019867", "lbl" : "outer membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019882", "lbl" : "antigen processing and presentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.", + "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149", "PMID:15771591", "PMID:15928678" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Antigen_presentation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0019953", "lbl" : "sexual reproduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).", + "xrefs" : [ "Wikipedia:Sexual_reproduction" ] + }, + "comments" : [ "Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times." ], + "xrefs" : [ { + "val" : "Wikipedia:Sexual_reproduction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021501", "lbl" : "prechordal plate formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021510", "lbl" : "spinal cord development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021514", "lbl" : "ventral spinal cord interneuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:11262869" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021515", "lbl" : "cell differentiation in spinal cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:11262869" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021517", "lbl" : "ventral spinal cord development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021522", "lbl" : "spinal cord motor neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:11262869" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021532", "lbl" : "neural tube patterning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021533", "lbl" : "cell differentiation in hindbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021534", "lbl" : "cell proliferation in hindbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021535", "lbl" : "cell migration in hindbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell that will reside in the hindbrain.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021545", "lbl" : "cranial nerve development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021546", "lbl" : "rhombomere development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021547", "lbl" : "midbrain-hindbrain boundary initiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:isa_complete", "GOC:jid", "GO_REF:0000021", "PMID:15541513" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021548", "lbl" : "pons development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021550", "lbl" : "medulla oblongata development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021551", "lbl" : "central nervous system morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021555", "lbl" : "midbrain-hindbrain boundary morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:15541513" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021556", "lbl" : "central nervous system formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021559", "lbl" : "trigeminal nerve development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021575", "lbl" : "hindbrain morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021576", "lbl" : "hindbrain formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021578", "lbl" : "hindbrain maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021579", "lbl" : "medulla oblongata morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021580", "lbl" : "medulla oblongata formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021582", "lbl" : "medulla oblongata maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021583", "lbl" : "pons morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021584", "lbl" : "pons formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021586", "lbl" : "pons maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021593", "lbl" : "rhombomere morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021594", "lbl" : "rhombomere formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021602", "lbl" : "cranial nerve morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021603", "lbl" : "cranial nerve formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021605", "lbl" : "cranial nerve maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021626", "lbl" : "central nervous system maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021635", "lbl" : "trigeminal nerve maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021636", "lbl" : "trigeminal nerve morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021638", "lbl" : "trigeminal nerve formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021654", "lbl" : "rhombomere boundary formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021675", "lbl" : "nerve development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021682", "lbl" : "nerve maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021700", "lbl" : "developmental maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021703", "lbl" : "locus ceruleus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021704", "lbl" : "locus ceruleus morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021705", "lbl" : "locus ceruleus formation", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0021706", - "lbl" : "locus ceruleus maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0021706", + "lbl" : "locus ceruleus maturation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021718", "lbl" : "superior olivary nucleus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021719", "lbl" : "superior olivary nucleus morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021720", "lbl" : "superior olivary nucleus formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021722", "lbl" : "superior olivary nucleus maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0838580343" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021732", "lbl" : "midbrain-hindbrain boundary maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:15541513" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021751", "lbl" : "salivary nucleus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:cls", "GOC:curators", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021753", "lbl" : "superior salivary nucleus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:cls", "GOC:curators", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021782", "lbl" : "glial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021903", "lbl" : "rostrocaudal neural tube patterning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the neural tube is divided into specific regions along the rostrocaudal axis.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:11262869" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021906", "lbl" : "hindbrain-spinal cord boundary formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:11262869" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021915", "lbl" : "neural tube development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021953", "lbl" : "central nervous system neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021954", "lbl" : "central nervous system neuron development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021990", "lbl" : "neural plate formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "ISBN:0878932437", "ISBN:0878932585", "PMID:15806586" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0021999", "lbl" : "neural plate anterior/posterior regionalization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022008", "lbl" : "neurogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Generation of cells within the nervous system.", + "xrefs" : [ "GOC:cls", "GOC:curators", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Neurogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022009", "lbl" : "central nervous system vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022035", "lbl" : "rhombomere cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere.", + "xrefs" : [ "GOC:cls", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021", "PMID:15629700" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022037", "lbl" : "metencephalon development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:cls", "GOC:curators", "GOC:dgh", "GOC:dph", "GOC:jid", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022402", "lbl" : "cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.", + "xrefs" : [ "GOC:isa_complete", "GOC:mtg_cell_cycle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022406", "lbl" : "membrane docking", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.", + "xrefs" : [ "GOC:isa_complete", "PMID:27875684" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022407", "lbl" : "regulation of cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022408", "lbl" : "negative regulation of cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022409", "lbl" : "positive regulation of cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of cell adhesion to another cell.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022411", "lbl" : "cellular component disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the breakdown of a cellular component.", + "xrefs" : [ "GOC:isa_complete" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022412", "lbl" : "cellular process involved in reproduction in multicellular organism", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022414", "lbl" : "reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Reproduction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022600", "lbl" : "digestive system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:isa_complete", "GOC:jid", "GOC:mtg_cardio" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022603", "lbl" : "regulation of anatomical structure morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022604", "lbl" : "regulation of cell morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022607", "lbl" : "cellular component assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a cellular component.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022612", "lbl" : "gland morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a gland are generated and organized.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022613", "lbl" : "ribonucleoprotein complex biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex.", + "xrefs" : [ "GOC:isa_complete", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022617", "lbl" : "extracellular matrix disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in the breakdown of the extracellular matrix.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0022618", "lbl" : "protein-RNA complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0022857", + "lbl" : "transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.", + "xrefs" : [ "GOC:jid", "GOC:mtg_transport", "ISBN:0815340729" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-1236947" + }, { + "val" : "Reactome:R-HSA-429036" + }, { + "val" : "Reactome:R-HSA-434650" + }, { + "val" : "Reactome:R-HSA-5638209" + }, { + "val" : "Reactome:R-HSA-5671707" + }, { + "val" : "Reactome:R-HSA-6784434" + }, { + "val" : "Reactome:R-HSA-6784436" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0022884", + "lbl" : "macromolecule transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a macromolecule from one side of a membrane to the other.", + "xrefs" : [ "GOC:mtg_transport", "ISBN:0815340729" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0022898", + "lbl" : "regulation of transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of transmembrane transporter activity.", + "xrefs" : [ "GOC:dph", "GOC:mtg_cardio", "GOC:mtg_transport" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023019", "lbl" : "signal transduction involved in regulation of gene expression", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.", + "xrefs" : [ "GOC:mtg_signal" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023051", "lbl" : "regulation of signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a signaling process.", + "xrefs" : [ "GOC:mtg_signal" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023052", "lbl" : "signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.", + "xrefs" : [ "GOC:mtg_signal", "GOC:mtg_signaling_feb11", "GOC:signaling" ] + }, + "comments" : [ "Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023056", "lbl" : "positive regulation of signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.", + "xrefs" : [ "GOC:mtg_signal" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023057", "lbl" : "negative regulation of signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.", + "xrefs" : [ "GOC:mtg_signal" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0023061", "lbl" : "signal release", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.", + "xrefs" : [ "GOC:mtg_signal" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030010", "lbl" : "establishment of cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specification and formation of anisotropic intracellular organization or cell growth patterns.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030016", "lbl" : "myofibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.", + "xrefs" : [ "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Myofibril" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030017", "lbl" : "sarcomere", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.", + "xrefs" : [ "ISBN:0815316194" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Sarcomere" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030029", "lbl" : "actin filament-based process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030030", "lbl" : "cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.", + "xrefs" : [ "GOC:jl", "GOC:mah", "PMID:16318917" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030031", "lbl" : "cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.", + "xrefs" : [ "GOC:jl", "GOC:mah", "PMID:18391171" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030033", "lbl" : "microvillus assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030036", "lbl" : "actin cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030048", "lbl" : "actin filament-based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030050", "lbl" : "vesicle transport along actin filament", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Movement of a vesicle along an actin filament, mediated by motor proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030054", "lbl" : "cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "GOC:mah", "ISBN:0198506732", "PMID:26820516", "PMID:28096264" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cell_junction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030072", "lbl" : "peptide hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of a peptide hormone from a cell.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030073", + "lbl" : "insulin secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030097", "lbl" : "hemopoiesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.", + "xrefs" : [ "GOC:dgh", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Haematopoiesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030098", "lbl" : "lymphocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.", + "xrefs" : [ "CL:0000542", "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030099", "lbl" : "myeloid cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030100", "lbl" : "regulation of endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030133", "lbl" : "transport vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.", + "xrefs" : [ "GOC:mah", "PMID:22160157" ] + }, + "comments" : [ "Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao885490876" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030141", "lbl" : "secretory granule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + }, + "comments" : [ "Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030154", "lbl" : "cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cellular_differentiation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030155", "lbl" : "regulation of cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030163", + "lbl" : "protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children." ], + "xrefs" : [ { + "val" : "Wikipedia:Protein_catabolism" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030182", "lbl" : "neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuron.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030198", "lbl" : "extracellular matrix organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030199", "lbl" : "collagen fibril organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030203", "lbl" : "glycosaminoglycan metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.", + "xrefs" : [ "ISBN:0192800981" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030212", "lbl" : "hyaluronan metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030213", "lbl" : "hyaluronan biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030214", + "lbl" : "hyaluronan catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "MetaCyc:PWY-7645" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030217", "lbl" : "T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.", + "xrefs" : [ "GOC:jid", "GOC:mah", "GO_REF:0000022" ] + }, + "comments" : [ "Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030218", "lbl" : "erythrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Erythropoiesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030219", "lbl" : "megakaryocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030224", "lbl" : "monocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030225", "lbl" : "macrophage differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030239", "lbl" : "myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of myofibrils, the repeating units of striated muscle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030261", "lbl" : "chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030262", "lbl" : "apoptotic nuclear changes", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030263", "lbl" : "apoptotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The compaction of chromatin during apoptosis.", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Pyknosis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030264", "lbl" : "nuclear fragmentation involved in apoptotic nuclear change", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:mtg_apoptosis", "GOC:tb", "ISBN:0721639976" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030278", "lbl" : "regulation of ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030279", "lbl" : "negative regulation of ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030307", "lbl" : "positive regulation of cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, extent or direction of cell growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030308", "lbl" : "negative regulation of cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030312", "lbl" : "external encapsulating structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030316", "lbl" : "osteoclast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.", + "xrefs" : [ "CL:0000092", "GOC:add", "ISBN:0781735149", "PMID:12161749" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030323", "lbl" : "respiratory tube development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030324", "lbl" : "lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.", + "xrefs" : [ "GOC:jid", "UBERON:0002048" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030334", "lbl" : "regulation of cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell migration.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030335", "lbl" : "positive regulation of cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell migration.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030336", "lbl" : "negative regulation of cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030397", "lbl" : "membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030421", + "lbl" : "defecation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expulsion of feces from the rectum.", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Defecation" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030432", + "lbl" : "peristalsis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Peristalsis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030473", "lbl" : "nuclear migration along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.", + "xrefs" : [ "GOC:mah", "GOC:sgd_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030485", "lbl" : "smooth muscle contractile fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The contractile fiber of smooth muscle cells.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030573", + "lbl" : "bile acid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0030574", + "lbl" : "collagen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.", + "xrefs" : [ "GOC:mah", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030595", "lbl" : "leukocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a leukocyte in response to an external stimulus.", + "xrefs" : [ "GOC:add", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030658", "lbl" : "transport vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a transport vesicle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030659", "lbl" : "cytoplasmic vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a cytoplasmic vesicle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030660", "lbl" : "Golgi-associated vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030667", "lbl" : "secretory granule membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a secretory granule.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030705", "lbl" : "cytoskeleton-dependent intracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030720", "lbl" : "oocyte localization involved in germarium-derived egg chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber.", + "xrefs" : [ "GOC:mtg_sensu", "PMID:10449356" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030851", "lbl" : "granulocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.", + "xrefs" : [ "GOC:ecd", "http://life.nthu.edu.tw/~g864204/dict-search1.htm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030852", "lbl" : "regulation of granulocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of granulocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030853", "lbl" : "negative regulation of granulocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030854", "lbl" : "positive regulation of granulocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030855", "lbl" : "epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.", + "xrefs" : [ "GOC:ecd", "PMID:11839751" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030856", "lbl" : "regulation of epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030857", "lbl" : "negative regulation of epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030858", "lbl" : "positive regulation of epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030885", "lbl" : "regulation of myeloid dendritic cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency or rate of myeloid dendritic cell activation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030886", "lbl" : "negative regulation of myeloid dendritic cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030887", "lbl" : "positive regulation of myeloid dendritic cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030901", "lbl" : "midbrain development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).", + "xrefs" : [ "PMID:4975589", "PMID:4992177" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030902", "lbl" : "hindbrain development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).", + "xrefs" : [ "PMID:4975589", "PMID:4992177" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030903", "lbl" : "notochord development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030917", "lbl" : "midbrain-hindbrain boundary development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030936", "lbl" : "transmembrane collagen trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collagen trimer that passes through a lipid bilayer membrane.", + "xrefs" : [ "ISBN:0721639976" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030951", "lbl" : "establishment or maintenance of microtubule cytoskeleton polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030952", "lbl" : "establishment or maintenance of cytoskeleton polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0030990", "lbl" : "intraciliary transport particle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.", + "xrefs" : [ "GOC:cilia", "GOC:kmv", "PMID:14570576", "PMID:22118932", "PMID:23945166" ] + }, + "comments" : [ "Note that we deem cilia and microtubule-based flagella to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031012", "lbl" : "extracellular matrix", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "GOC:rph", "NIF_Subcellular:nlx_subcell_20090513", "PMID:21123617", "PMID:28089324" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:nlx_subcell_20090513" + }, { + "val" : "Wikipedia:Extracellular_matrix" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031016", + "lbl" : "pancreas development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones.", + "xrefs" : [ "GOC:cvs" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Pancreas" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031017", + "lbl" : "exocrine pancreas development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.", + "xrefs" : [ "GOC:cvs" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031018", + "lbl" : "endocrine pancreas development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.", + "xrefs" : [ "GOC:cvs" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031022", "lbl" : "nuclear migration along microfilament", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031032", "lbl" : "actomyosin structure organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + }, + "comments" : [ "Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031045", "lbl" : "dense core granule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.", + "xrefs" : [ "NIF_Subcellular:sao772007592", "PMID:14690495" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao772007592" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031076", "lbl" : "embryonic camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:mah", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031090", "lbl" : "organelle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.", + "xrefs" : [ "GOC:dos", "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao830981606" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031109", "lbl" : "microtubule polymerization or depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031110", "lbl" : "regulation of microtubule polymerization or depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031111", "lbl" : "negative regulation of microtubule polymerization or depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031112", "lbl" : "positive regulation of microtubule polymerization or depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031113", "lbl" : "regulation of microtubule polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of microtubule polymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031114", "lbl" : "regulation of microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of microtubule depolymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031115", "lbl" : "negative regulation of microtubule polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031116", "lbl" : "positive regulation of microtubule polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of microtubule polymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031117", "lbl" : "positive regulation of microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031122", "lbl" : "cytoplasmic microtubule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031128", "lbl" : "developmental induction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder).", + "xrefs" : [ "GOC:cjm", "GOC:dph", "GOC:mah", "PMID:24503535" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031143", "lbl" : "pseudopodium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.", + "xrefs" : [ "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Pseudopod" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031175", "lbl" : "neuron projection development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031252", "lbl" : "cell leading edge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The area of a motile cell closest to the direction of movement.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031253", "lbl" : "cell projection membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.", + "xrefs" : [ "GOC:krc", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031256", "lbl" : "leading edge membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the plasma membrane surrounding the leading edge of a motile cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031268", "lbl" : "pseudopodium organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031269", "lbl" : "pseudopodium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:pg", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031270", "lbl" : "pseudopodium retraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The myosin-based contraction and retraction of a pseudopodium.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031272", "lbl" : "regulation of pseudopodium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031273", "lbl" : "negative regulation of pseudopodium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031274", "lbl" : "positive regulation of pseudopodium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031323", "lbl" : "regulation of cellular metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031324", "lbl" : "negative regulation of cellular metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031325", "lbl" : "positive regulation of cellular metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031326", "lbl" : "regulation of cellular biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031327", "lbl" : "negative regulation of cellular biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031328", "lbl" : "positive regulation of cellular biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031329", + "lbl" : "regulation of cellular catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031330", + "lbl" : "negative regulation of cellular catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031331", + "lbl" : "positive regulation of cellular catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031333", "lbl" : "negative regulation of protein-containing complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031334", "lbl" : "positive regulation of protein-containing complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein complex assembly.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031338", "lbl" : "regulation of vesicle fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vesicle fusion.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031339", "lbl" : "negative regulation of vesicle fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031340", "lbl" : "positive regulation of vesicle fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vesicle fusion.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031344", "lbl" : "regulation of cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031345", "lbl" : "negative regulation of cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031346", "lbl" : "positive regulation of cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031347", "lbl" : "regulation of defense response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a defense response.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031348", "lbl" : "negative regulation of defense response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031349", "lbl" : "positive regulation of defense response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a defense response.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031410", "lbl" : "cytoplasmic vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle found in the cytoplasm of a cell.", + "xrefs" : [ "GOC:ai", "GOC:mah", "GOC:vesicles" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao180601769" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031503", "lbl" : "protein-containing complex localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031514", "lbl" : "motile cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.", + "xrefs" : [ "GOC:cilia", "GOC:dgh", "GOC:kmv", "PMID:17009929", "PMID:20144998", "PMID:22118931" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031594", "lbl" : "neuromuscular junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.", + "xrefs" : [ "GOC:nln" ] + }, + "comments" : [ "In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1124888485" + }, { + "val" : "Wikipedia:Neuromuscular_junction" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031644", "lbl" : "regulation of nervous system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031645", "lbl" : "negative regulation of nervous system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031646", "lbl" : "positive regulation of nervous system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a neurophysiological process.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031965", "lbl" : "nuclear membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.", + "xrefs" : [ "GOC:mah", "GOC:pz" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1687101204" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031967", "lbl" : "organelle envelope", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.", + "xrefs" : [ "GOC:mah", "GOC:pz" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031968", "lbl" : "organelle outer membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031974", "lbl" : "membrane-enclosed lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.", + "xrefs" : [ "GOC:add", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031981", "lbl" : "nuclear lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The volume enclosed by the nuclear inner membrane.", + "xrefs" : [ "GOC:mah", "GOC:pz" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0031982", "lbl" : "vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any small, fluid-filled, spherical organelle enclosed by membrane.", + "xrefs" : [ "GOC:mah", "GOC:pz", "GOC:vesicles" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao221389602" + }, { + "val" : "Wikipedia:Vesicle_(biology)" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0031987", + "lbl" : "locomotion involved in locomotory behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032024", + "lbl" : "positive regulation of insulin secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032057", "lbl" : "negative regulation of translational initiation in response to stress", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032058", "lbl" : "positive regulation of translational initiation in response to stress", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032059", "lbl" : "bleb", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.", + "xrefs" : [ "GOC:mtg_apoptosis", "PMID:12083798", "PMID:16624291", "Wikipedia:Bleb_(cell_biology)" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Bleb_(cell_biology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032060", "lbl" : "bleb assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis", "PMID:12083798", "PMID:16624291", "Wikipedia:Bleb_(cell_biology)" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032069", + "lbl" : "regulation of nuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032070", + "lbl" : "regulation of deoxyribonuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032074", + "lbl" : "negative regulation of nuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032075", + "lbl" : "positive regulation of nuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032076", + "lbl" : "negative regulation of deoxyribonuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032077", + "lbl" : "positive regulation of deoxyribonuclease activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032101", "lbl" : "regulation of response to external stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032102", "lbl" : "negative regulation of response to external stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032103", "lbl" : "positive regulation of response to external stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of a response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032127", "lbl" : "dense core granule membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a dense core granule.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032231", "lbl" : "regulation of actin filament bundle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032232", "lbl" : "negative regulation of actin filament bundle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032233", "lbl" : "positive regulation of actin filament bundle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032239", "lbl" : "regulation of nucleobase-containing compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032240", "lbl" : "negative regulation of nucleobase-containing compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032241", "lbl" : "positive regulation of nucleobase-containing compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032252", "lbl" : "secretory granule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032253", "lbl" : "dense core granule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032271", "lbl" : "regulation of protein polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the process of creating protein polymers.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032272", "lbl" : "negative regulation of protein polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032273", "lbl" : "positive regulation of protein polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032330", "lbl" : "regulation of chondrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of chondrocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032331", "lbl" : "negative regulation of chondrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032332", "lbl" : "positive regulation of chondrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032364", + "lbl" : "intracellular oxygen homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell.", + "xrefs" : [ "GOC:rph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032365", "lbl" : "intracellular lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of lipids within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032368", "lbl" : "regulation of lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032369", "lbl" : "negative regulation of lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032370", "lbl" : "positive regulation of lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032377", "lbl" : "regulation of intracellular lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032378", "lbl" : "negative regulation of intracellular lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032379", "lbl" : "positive regulation of intracellular lipid transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032386", "lbl" : "regulation of intracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032387", "lbl" : "negative regulation of intracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032388", "lbl" : "positive regulation of intracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032409", + "lbl" : "regulation of transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the activity of a transporter.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032410", + "lbl" : "negative regulation of transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the activity of a transporter.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032411", + "lbl" : "positive regulation of transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the activity of a transporter.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032412", + "lbl" : "regulation of monoatomic ion transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the activity of an ion transporter.", + "xrefs" : [ "GOC:mah", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032413", + "lbl" : "negative regulation of ion transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the activity of an ion transporter.", + "xrefs" : [ "GOC:mah", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032414", + "lbl" : "positive regulation of ion transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the activity of an ion transporter.", + "xrefs" : [ "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032418", "lbl" : "lysosome localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a lysosome is transported to, and/or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032432", "lbl" : "actin filament bundle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032501", "lbl" : "multicellular organismal process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process, occurring at the level of a multicellular organism, pertinent to its function.", + "xrefs" : [ "GOC:curators", "GOC:dph", "GOC:isa_complete", "GOC:tb" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032502", "lbl" : "developmental process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032528", "lbl" : "microvillus organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032530", "lbl" : "regulation of microvillus organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032534", "lbl" : "regulation of microvillus assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that modulates the formation of a microvillus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032589", "lbl" : "neuron projection membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the plasma membrane surrounding a neuron projection.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032594", "lbl" : "protein transport within lipid bilayer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein from one location to another within a lipid bilayer.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032774", "lbl" : "RNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.", + "xrefs" : [ "GOC:mah", "GOC:txnOH" ] + }, + "comments" : [ "Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032782", + "lbl" : "bile acid secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.", + "xrefs" : [ "GOC:ecd" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032787", + "lbl" : "monocarboxylic acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032790", "lbl" : "ribosome disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.", + "xrefs" : [ "GOC:mah", "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032838", "lbl" : "plasma membrane bounded cell projection cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.", + "xrefs" : [ "GOC:krc", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032868", + "lbl" : "response to insulin", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032869", + "lbl" : "cellular response to insulin stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032871", "lbl" : "regulation of karyogamy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032878", "lbl" : "regulation of establishment or maintenance of cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032879", "lbl" : "regulation of localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032880", "lbl" : "regulation of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032881", "lbl" : "regulation of polysaccharide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032885", "lbl" : "regulation of polysaccharide biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032886", "lbl" : "regulation of microtubule-based process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032890", + "lbl" : "regulation of organic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032891", + "lbl" : "negative regulation of organic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032892", + "lbl" : "positive regulation of organic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032940", "lbl" : "secretion by cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of a substance by a cell.", + "xrefs" : [ "GOC:mah" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Secretion" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0032941", + "lbl" : "secretion by tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of a substance by a tissue.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032943", "lbl" : "mononuclear cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032944", "lbl" : "regulation of mononuclear cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032945", "lbl" : "negative regulation of mononuclear cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032946", "lbl" : "positive regulation of mononuclear cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032956", "lbl" : "regulation of actin cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032963", "lbl" : "collagen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032964", "lbl" : "collagen biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).", + "xrefs" : [ "GOC:mah", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032965", "lbl" : "regulation of collagen biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032966", "lbl" : "negative regulation of collagen biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032967", "lbl" : "positive regulation of collagen biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032970", "lbl" : "regulation of actin filament-based process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032984", "lbl" : "protein-containing complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a protein-containing macromolecular complex into its constituent components.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032986", "lbl" : "protein-DNA complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a protein-DNA complex into its constituent components.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032988", "lbl" : "protein-RNA complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a protein-RNA complex into its constituent components.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032989", "lbl" : "cellular anatomical entity morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032991", "lbl" : "protein-containing complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.", + "xrefs" : [ "GOC:dos", "GOC:mah" ] + }, + "comments" : [ "A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032993", "lbl" : "protein-DNA complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macromolecular complex containing both protein and DNA molecules.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0032997", "lbl" : "Fc receptor complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033001", "lbl" : "Fc-gamma receptor III complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:11244038", "PMID:12413532" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033002", "lbl" : "muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a muscle cell population by cell division.", + "xrefs" : [ "CL:0000187", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033028", "lbl" : "myeloid cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.", + "xrefs" : [ "CL:0000763", "GOC:add", "GOC:mtg_apoptosis", "PMID:11292031", "PMID:15330259", "PMID:17133093" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033032", "lbl" : "regulation of myeloid cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033033", "lbl" : "negative regulation of myeloid cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033034", "lbl" : "positive regulation of myeloid cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033036", "lbl" : "macromolecule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a macromolecule is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033037", "lbl" : "polysaccharide localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a polysaccharide is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033043", "lbl" : "regulation of organelle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033044", "lbl" : "regulation of chromosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033045", "lbl" : "regulation of sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of sister chromatid segregation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033046", "lbl" : "negative regulation of sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033047", "lbl" : "regulation of mitotic sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033048", "lbl" : "negative regulation of mitotic sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033059", "lbl" : "cellular pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The deposition or aggregation of coloring matter in a cell.", + "xrefs" : [ "GOC:mtg_MIT_16mar07" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033157", "lbl" : "regulation of intracellular protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033238", "lbl" : "regulation of amine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033239", "lbl" : "negative regulation of amine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033240", "lbl" : "positive regulation of amine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0033241", + "lbl" : "regulation of amine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0033242", + "lbl" : "negative regulation of amine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0033243", + "lbl" : "positive regulation of amine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033278", "lbl" : "cell proliferation in midbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.", + "xrefs" : [ "GOC:dgf", "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033363", "lbl" : "secretory granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033365", "lbl" : "protein localization to organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within an organelle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033366", "lbl" : "protein localization to secretory granule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a secretory granule.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033371", "lbl" : "T cell secretory granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0033500", + "lbl" : "carbohydrate homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033604", "lbl" : "negative regulation of catecholamine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033605", "lbl" : "positive regulation of catecholamine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033750", "lbl" : "ribosome localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a ribosome is transported to, and/or maintained in, a specific location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033762", "lbl" : "response to glucagon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0033993", "lbl" : "response to lipid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034067", "lbl" : "protein localization to Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034101", "lbl" : "erythrocyte homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process of regulating the production and elimination of erythrocytes within an organism.", + "xrefs" : [ "GOC:add", "PMID:10694114", "PMID:14754397" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034103", "lbl" : "regulation of tissue remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of tissue remodeling.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034104", "lbl" : "negative regulation of tissue remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034105", "lbl" : "positive regulation of tissue remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of tissue remodeling.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034219", "lbl" : "carbohydrate transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a carbohydrate is transported across a membrane.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034220", "lbl" : "monoatomic ion transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034242", "lbl" : "negative regulation of syncytium formation by plasma membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034248", "lbl" : "regulation of amide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034249", "lbl" : "negative regulation of amide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034250", "lbl" : "positive regulation of amide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0034251", + "lbl" : "regulation of amide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0034252", + "lbl" : "negative regulation of amide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0034253", + "lbl" : "positive regulation of amide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034329", "lbl" : "cell junction assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034330", "lbl" : "cell junction organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.", + "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034349", "lbl" : "glial cell apoptotic process", - "type" : "CLASS" - }, { + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.", + "xrefs" : [ "CL:0000125", "GOC:mtg_apoptosis", "GOC:sart" ] + } + } + }, { "id" : "http://purl.obolibrary.org/obo/GO_0034350", "lbl" : "regulation of glial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034351", "lbl" : "negative regulation of glial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034352", "lbl" : "positive regulation of glial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034390", "lbl" : "smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels.", + "xrefs" : [ "CL:0000192", "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034391", "lbl" : "regulation of smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034392", "lbl" : "negative regulation of smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034393", "lbl" : "positive regulation of smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034436", "lbl" : "glycoprotein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034486", "lbl" : "vacuolar transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a solute is transported from one side of the vacuolar membrane to the other.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034502", "lbl" : "protein localization to chromosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034504", "lbl" : "protein localization to nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein transports or maintains the localization of another protein to the nucleus.", + "xrefs" : [ "GOC:ecd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034654", "lbl" : "nucleobase-containing compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0034655", + "lbl" : "nucleobase-containing compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034762", "lbl" : "regulation of transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034763", "lbl" : "negative regulation of transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034764", "lbl" : "positive regulation of transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034765", "lbl" : "regulation of monoatomic ion transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034766", "lbl" : "negative regulation of monoatomic ion transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034767", "lbl" : "positive regulation of monoatomic ion transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0034769", "lbl" : "basement membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.", + "xrefs" : [ "GOC:sart", "PMID:17301221" ] + }, + "comments" : [ "Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035050", "lbl" : "embryonic heart tube development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035051", "lbl" : "cardiocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035082", "lbl" : "axoneme assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.", + "xrefs" : [ "GOC:bf", "GOC:cilia", "GOC:jl", "ISBN:0815316194" ] + }, + "comments" : [ "Note that cilia and eukaryotic flagella are deemed to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035107", "lbl" : "appendage morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.", + "xrefs" : [ "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035112", "lbl" : "genitalia morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035148", "lbl" : "tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035190", "lbl" : "syncytial nuclear migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex.", + "xrefs" : [ "GOC:bf", "ISBN:0879694238", "PMID:8314839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035234", "lbl" : "ectopic germ cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.", + "xrefs" : [ "PMID:12814944" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035239", "lbl" : "tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.", + "xrefs" : [ "GOC:bf", "PMID:14624839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035260", "lbl" : "internal genitalia morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.", + "xrefs" : [ "PMID:24793987", "PMID:25247640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035261", "lbl" : "external genitalia morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals.", + "xrefs" : [ "PMID:24793987", "PMID:25247640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035262", "lbl" : "gonad morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.", + "xrefs" : [ "ISBN:0198612001" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035264", "lbl" : "multicellular organism growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an entire multicellular organism, as opposed to cell growth.", + "xrefs" : [ "GOC:bf", "GOC:curators", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035265", "lbl" : "organ growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.", + "xrefs" : [ "GOC:bf", "ISBN:0471245208", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035270", "lbl" : "endocrine system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.", + "xrefs" : [ "GOC:bf", "Wikipedia:Development_of_the_endocrine_system" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035272", "lbl" : "exocrine system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system.", + "xrefs" : [ "GOC:bf", "Wikipedia:Exocrine_gland" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035282", "lbl" : "segmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.", + "xrefs" : [ "PMID:10611687", "PMID:9706689" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Segmentation_(biology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035290", "lbl" : "trunk segmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8.", + "xrefs" : [ "PMID:1360402" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035295", "lbl" : "tube development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.", + "xrefs" : [ "PMID:12526790" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035372", "lbl" : "protein localization to microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained at, a microtubule.", + "xrefs" : [ "GOC:bf", "GOC:lb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035418", "lbl" : "protein localization to synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035441", "lbl" : "cell migration involved in vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035556", "lbl" : "intracellular signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.", + "xrefs" : [ "GOC:bf", "GOC:jl", "GOC:signaling", "ISBN:3527303782" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035577", "lbl" : "azurophil granule membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.", + "xrefs" : [ "GOC:bf", "PMID:17152095" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035592", "lbl" : "establishment of protein localization to extracellular region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location within the extracellular region.", + "xrefs" : [ "GOC:BHF", "GOC:bf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035622", + "lbl" : "intrahepatic bile duct development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).", + "xrefs" : [ "GOC:bf", "PMID:20614624" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035628", + "lbl" : "cystic duct development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct.", + "xrefs" : [ "PMID:20614624" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035645", + "lbl" : "enteric smooth muscle cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine.", + "xrefs" : [ "CL:0002504", "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035701", "lbl" : "hematopoietic stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.", + "xrefs" : [ "CL:0000037", "GOC:BHF", "PMID:20234092" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035702", "lbl" : "monocyte homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "CL:0000576", "GOC:BHF", "PMID:18832716" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035735", "lbl" : "intraciliary transport involved in cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.", + "xrefs" : [ "GOC:bf", "GOC:cilia" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035736", "lbl" : "cell proliferation involved in compound eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis.", + "xrefs" : [ "GOC:bf", "GOC:sart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035767", "lbl" : "endothelial cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).", + "xrefs" : [ "CL:0000115", "GOC:BHF" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035773", + "lbl" : "insulin secretion involved in cellular response to glucose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus.", + "xrefs" : [ "GOC:bf", "GOC:yaf", "PMID:8492079" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035774", + "lbl" : "positive regulation of insulin secretion involved in cellular response to glucose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.", + "xrefs" : [ "GOC:bf", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035779", "lbl" : "angioblast cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells).", + "xrefs" : [ "CL:0000566", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035805", "lbl" : "egg coat", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.", + "xrefs" : [ "PMID:16944418", "PMID:17163408" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0035844", + "lbl" : "cloaca development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates.", + "xrefs" : [ "GOC:dgh", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035855", "lbl" : "megakaryocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.", + "xrefs" : [ "CL:0000556", "GOC:BHF", "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035869", "lbl" : "ciliary transition zone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.", + "xrefs" : [ "GOC:cilia", "GOC:kmv", "PMID:21422230" ] + }, + "comments" : [ "Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035883", "lbl" : "enteroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.", + "xrefs" : [ "CL:0000164", "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035886", "lbl" : "vascular associated smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.", + "xrefs" : [ "GOC:sl", "PMID:16151017", "PMID:18267954" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035887", "lbl" : "aortic smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035904", "lbl" : "aorta development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0000062", "UBERON:0000947", "Wikipedia:Aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035905", "lbl" : "ascending aorta development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0002570", "UBERON:0001496", "Wikipedia:Ascending_aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035906", "lbl" : "descending aorta development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0002571", "UBERON:0001514", "Wikipedia:Descending_aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035907", "lbl" : "dorsal aorta development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "UBERON:0005805", "Wikipedia:Aorta", "ZFA:0000014" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035909", "lbl" : "aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0000062", "UBERON:0000947", "Wikipedia:Aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035910", "lbl" : "ascending aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0002570", "UBERON:0001496", "Wikipedia:Ascending_aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035911", "lbl" : "descending aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "MA:0002571", "UBERON:0001514", "Wikipedia:Descending_aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035912", "lbl" : "dorsal aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "UBERON:0005805", "Wikipedia:Aorta", "ZFA:0000014" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035914", "lbl" : "skeletal muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.", + "xrefs" : [ "CL:0000188", "GOC:BHF", "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035929", "lbl" : "steroid hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of any steroid that acts as a hormone into the circulatory system.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035935", "lbl" : "androgen secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035987", "lbl" : "endodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.", + "xrefs" : [ "CL:0000223", "GOC:yaf", "PMID:17624332" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035989", "lbl" : "tendon development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.", + "xrefs" : [ "GOC:yaf", "PMID:21412429", "UBERON:0000043" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0035992", "lbl" : "tendon formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts.", + "xrefs" : [ "GOC:yaf", "PMID:17567668", "UBERON:0000043" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036035", "lbl" : "osteoclast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.", + "xrefs" : [ "CL:0000092", "GOC:bf", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036072", "lbl" : "direct ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues.", + "xrefs" : [ "GO_REF:0000034" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036093", "lbl" : "germ cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population.", + "xrefs" : [ "CL:0000586", "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036145", "lbl" : "dendritic cell homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "CL:0000451", "GOC:uh", "PMID:12570827", "PMID:19176316" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036179", "lbl" : "osteoclast maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes.", + "xrefs" : [ "CL:0000092", "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036194", "lbl" : "muscle cell projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.", + "xrefs" : [ "CL:0000187", "GOC:kmv", "PMID:15930100", "PMID:22464329" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036195", "lbl" : "muscle cell projection membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the plasma membrane surrounding a muscle cell projection.", + "xrefs" : [ "CL:0000187", "GOC:kmv", "PMID:15930100", "PMID:22464329" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036230", "lbl" : "granulocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "CL:0000094", "GOC:nhn" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036293", "lbl" : "response to decreased oxygen levels", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.", + "xrefs" : [ "GOC:al" ] + }, + "comments" : [ "This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0036333", + "lbl" : "hepatocyte homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules.", + "xrefs" : [ "CL:0000182", "GOC:nhn", "PMID:19878874" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036334", "lbl" : "epidermal stem cell homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells.", + "xrefs" : [ "CL:1000428", "GOC:nhn", "PMID:17666529" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036336", "lbl" : "dendritic cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a dendritic cell within or between different tissues and organs of the body.", + "xrefs" : [ "CL:0000451", "GOC:nhn", "PMID:19339990" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0036342", + "lbl" : "post-anal tail morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.", + "xrefs" : [ "GOC:bf", "GOC:kmv", "Wikipedia:Chordate" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036477", "lbl" : "somatodendritic compartment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.", + "xrefs" : [ "GOC:PARL", "GOC:pad" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036484", "lbl" : "trunk neural crest cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "GOC:mat", "PMID:2387238" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0036504", "lbl" : "Golgi membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "PMID:12473691" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040007", "lbl" : "growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an entire organism, a part of an organism or a cell.", + "xrefs" : [ "GOC:bf", "GOC:ma" ] + }, + "comments" : [ "See also the biological process term 'cell growth ; GO:0016049'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040008", "lbl" : "regulation of growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.", + "xrefs" : [ "GOC:ems", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040011", "lbl" : "locomotion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Self-propelled movement of a cell or organism from one location to another.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040012", "lbl" : "regulation of locomotion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.", + "xrefs" : [ "GOC:ems" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040013", "lbl" : "negative regulation of locomotion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040014", "lbl" : "regulation of multicellular organism growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040015", "lbl" : "negative regulation of multicellular organism growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.", + "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040016", "lbl" : "embryonic cleavage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first few specialized divisions of an activated animal egg.", + "xrefs" : [ "GOC:clt", "ISBN:0070524300" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040017", "lbl" : "positive regulation of locomotion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040018", "lbl" : "positive regulation of multicellular organism growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040019", "lbl" : "positive regulation of embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of embryonic development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040020", "lbl" : "regulation of meiotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.", + "xrefs" : [ "GOC:ems", "GOC:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0040034", "lbl" : "regulation of development, heterochronic", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.", + "xrefs" : [ "PMID:9442909" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042063", "lbl" : "gliogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.", + "xrefs" : [ "GOC:dgh", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042065", "lbl" : "glial cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042069", "lbl" : "regulation of catecholamine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042073", "lbl" : "intraciliary transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.", + "xrefs" : [ "GOC:cilia", "GOC:kmv", "PMID:17981739", "PMID:18180368", "PMID:22869374" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ], + "xrefs" : [ { + "val" : "Wikipedia:Intraflagellar_transport" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042074", "lbl" : "cell migration involved in gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).", + "xrefs" : [ "GOC:jl", "PMID:16099638" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042078", "lbl" : "germ-line stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.", + "xrefs" : [ "GOC:jid", "PMID:2279698" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042098", "lbl" : "T cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a T cell population by cell division. Follows T cell activation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042102", "lbl" : "positive regulation of T cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of T cell proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042103", "lbl" : "positive regulation of T cell homeostatic proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of resting T cell proliferation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042110", "lbl" : "T cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042116", "lbl" : "macrophage activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149", "PMID:14506301" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042117", "lbl" : "monocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042118", "lbl" : "endothelial cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149", "PMID:12851652", "PMID:14581484" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042127", "lbl" : "regulation of cell population proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042129", "lbl" : "regulation of T cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of T cell proliferation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042130", "lbl" : "negative regulation of T cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of T cell proliferation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042157", "lbl" : "lipoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042158", "lbl" : "lipoprotein biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042159", + "lbl" : "lipoprotein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042175", "lbl" : "nuclear outer membrane-endoplasmic reticulum membrane network", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.", + "xrefs" : [ "GOC:bf", "GOC:jl", "GOC:mah", "GOC:mcc", "GOC:pr", "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042176", + "lbl" : "regulation of protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.", + "xrefs" : [ "GOC:go_curators", "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042177", + "lbl" : "negative regulation of protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "GOC:obol", "GO_REF:0000058", "PMID:24785082" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042180", + "lbl" : "cellular ketone metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.", + "xrefs" : [ "GOC:jl", "ISBN:0787650153" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042181", + "lbl" : "ketone biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042182", + "lbl" : "ketone catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042221", "lbl" : "response to chemical", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.", + "xrefs" : [ "GOC:jl" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042254", "lbl" : "ribosome biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.", + "xrefs" : [ "GOC:ma", "PMID:26404467", "Wikipedia:Ribosome_biogenesis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042255", "lbl" : "ribosome assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.", + "xrefs" : [ "GOC:ma", "PMID:30467428" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042330", "lbl" : "taxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a motile cell or organism in response to an external stimulus.", + "xrefs" : [ "GOC:jl", "ISBN:0192801023" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Taxis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042391", "lbl" : "regulation of membrane potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.", + "xrefs" : [ "GOC:jl", "GOC:mtg_cardio", "GOC:tb", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042401", "lbl" : "biogenic amine biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.", + "xrefs" : [ "GOC:jl", "ISBN:0395825172" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042402", + "lbl" : "cellular biogenic amine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.", + "xrefs" : [ "GOC:go_curators", "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042415", "lbl" : "norepinephrine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042421", "lbl" : "norepinephrine biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042422", + "lbl" : "norepinephrine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Norepinephrine#Degradation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042423", "lbl" : "catecholamine biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Catecholamines" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042424", + "lbl" : "catecholamine catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042427", "lbl" : "serotonin biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Serotonin" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042428", "lbl" : "serotonin metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042429", + "lbl" : "serotonin catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042430", "lbl" : "indole-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton.", + "xrefs" : [ "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042435", "lbl" : "indole-containing compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042436", + "lbl" : "indole-containing compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042461", "lbl" : "photoreceptor cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042462", "lbl" : "eye photoreceptor cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.", + "xrefs" : [ "GOC:jl", "ISBN:0192800981" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042478", "lbl" : "regulation of eye photoreceptor cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of eye photoreceptor development.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042479", "lbl" : "positive regulation of eye photoreceptor cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042480", "lbl" : "negative regulation of eye photoreceptor cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042551", "lbl" : "neuron maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.", + "xrefs" : [ "GOC:dph", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042582", "lbl" : "azurophil granule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primary lysosomal granule readily stainable with a Romanowsky stain.", + "xrefs" : [ "GOC:jl", "PMID:17152095", "PMID:28717070", "PMID:5914694", "WIKIPEDIA:Azurophilic_granule" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042588", + "lbl" : "zymogen granule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042589", + "lbl" : "zymogen granule membrane", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a zymogen granule.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042592", "lbl" : "homeostatic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of an internal steady state.", + "xrefs" : [ "GOC:jl", "ISBN:0395825172" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042593", + "lbl" : "glucose homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042611", "lbl" : "MHC protein complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.", + "xrefs" : [ "GOC:add", "GOC:jl", "ISBN:0781735149", "PMID:15928678", "PMID:16153240" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042613", "lbl" : "MHC class II protein complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.", + "xrefs" : [ "GOC:add", "GOC:jl", "ISBN:0120781859", "PMID:15928678" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042641", "lbl" : "actomyosin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any complex of actin, myosin, and accessory proteins.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042670", "lbl" : "retinal cone cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042692", "lbl" : "muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.", + "xrefs" : [ "CL:0000187", "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042742", "lbl" : "defense response to bacterium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042886", "lbl" : "amide transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042887", + "lbl" : "amide transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042953", "lbl" : "lipoprotein transport", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0042981", - "lbl" : "regulation of apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:jl", "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0042981", + "lbl" : "regulation of apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the occurrence or rate of cell death by apoptotic process.", + "xrefs" : [ "GOC:jl", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042995", "lbl" : "cell projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A prolongation or process extending from a cell, e.g. a flagellum or axon.", + "xrefs" : [ "GOC:jl", "PMID:16318917" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042996", "lbl" : "regulation of Golgi to plasma membrane protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042997", "lbl" : "negative regulation of Golgi to plasma membrane protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0042998", "lbl" : "positive regulation of Golgi to plasma membrane protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043001", "lbl" : "Golgi to plasma membrane protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.", + "xrefs" : [ "ISBN:0716731363" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043005", "lbl" : "neuron projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.", + "xrefs" : [ "GOC:jl", "PMID:3077060" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao867568886" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043009", "lbl" : "chordate embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.", + "xrefs" : [ "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043010", "lbl" : "camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043011", "lbl" : "myeloid dendritic cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.", + "xrefs" : [ "CL:0000782", "GOC:jl" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Dendritic_cell" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043025", "lbl" : "neuronal cell body", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections." ], + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1044911821" + }, { + "val" : "Wikipedia:Soma_(biology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043029", "lbl" : "T cell homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + }, + "comments" : [ "Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043030", "lbl" : "regulation of macrophage activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency or rate of macrophage activation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043031", "lbl" : "negative regulation of macrophage activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043032", "lbl" : "positive regulation of macrophage activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stimulates, induces or increases the rate of macrophage activation.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043043", "lbl" : "peptide biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide.", + "xrefs" : [ "GOC:dph", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043062", "lbl" : "extracellular structure organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043065", "lbl" : "positive regulation of apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.", + "xrefs" : [ "GOC:jl", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043066", "lbl" : "negative regulation of apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.", + "xrefs" : [ "GOC:jl", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043067", "lbl" : "regulation of programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043068", "lbl" : "positive regulation of programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043069", "lbl" : "negative regulation of programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043073", "lbl" : "germ cell nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The nucleus of a germ cell, a reproductive cell in multicellular organisms.", + "xrefs" : [ "CL:0000586", "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043085", + "lbl" : "positive regulation of catalytic activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the activity of an enzyme.", + "xrefs" : [ "GOC:ebc", "GOC:jl", "GOC:tb", "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043086", + "lbl" : "negative regulation of catalytic activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the activity of an enzyme.", + "xrefs" : [ "GOC:ebc", "GOC:jl", "GOC:tb", "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043129", "lbl" : "surfactant homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid.", + "xrefs" : [ "PMID:23708874", "PMID:9751757" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043133", + "lbl" : "hindgut contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine.", + "xrefs" : [ "GOC:jl", "GOC:mtg_muscle", "UBERON:0001046" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043134", + "lbl" : "regulation of hindgut contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.", + "xrefs" : [ "GOC:jl", "UBERON:0001046" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043143", "lbl" : "regulation of translation by machinery localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043170", "lbl" : "macromolecule metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043171", + "lbl" : "peptide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043207", "lbl" : "response to external biotic stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043226", "lbl" : "organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1539965131" + }, { + "val" : "Wikipedia:Organelle" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043227", "lbl" : "membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao414196390" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043228", "lbl" : "non-membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1456184038" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043229", "lbl" : "intracellular organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043230", "lbl" : "extracellular organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.", + "xrefs" : [ "GOC:jl", "PMID:9914479" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043231", "lbl" : "intracellular membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043232", "lbl" : "intracellular non-membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043233", "lbl" : "organelle lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.", + "xrefs" : [ "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043242", "lbl" : "negative regulation of protein-containing complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043243", "lbl" : "positive regulation of protein-containing complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043244", "lbl" : "regulation of protein-containing complex disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043249", "lbl" : "erythrocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.", + "xrefs" : [ "GOC:devbiol", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043254", "lbl" : "regulation of protein-containing complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein complex assembly.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043255", "lbl" : "regulation of carbohydrate biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043264", "lbl" : "extracellular non-membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043269", "lbl" : "regulation of monoatomic ion transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043270", "lbl" : "positive regulation of monoatomic ion transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043271", "lbl" : "negative regulation of monoatomic ion transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043292", "lbl" : "contractile muscle fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.", + "xrefs" : [ "GOC:go_curators", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043362", "lbl" : "nucleate erythrocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus.", + "xrefs" : [ "GOC:devbiol", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043363", "lbl" : "nucleate erythrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043434", "lbl" : "response to peptide hormone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.", + "xrefs" : [ "PMID:11027914", "PMID:15134857", "Wikipedia:Peptide_hormone" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043436", + "lbl" : "oxoacid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).", + "xrefs" : [ "Wikipedia:Oxyacid" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043467", + "lbl" : "regulation of generation of precursor metabolites and energy", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043470", + "lbl" : "regulation of carbohydrate catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates.", + "xrefs" : [ "GOC:mlg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043473", "lbl" : "pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043500", "lbl" : "muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.", + "xrefs" : [ "GOC:mtg_muscle", "PMID:11181628", "PMID:11449884", "PMID:12605307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043501", "lbl" : "skeletal muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals.", + "xrefs" : [ "GOC:mtg_muscle", "PMID:11181628", "PMID:11449884", "PMID:12605307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043502", "lbl" : "regulation of muscle adaptation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle adaptation.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043523", "lbl" : "regulation of neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043524", "lbl" : "negative regulation of neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043525", "lbl" : "positive regulation of neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.", + "xrefs" : [ "GOC:go_curators", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043534", "lbl" : "blood vessel endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis.", + "xrefs" : [ "PMID:11166264" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043535", "lbl" : "regulation of blood vessel endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043536", "lbl" : "positive regulation of blood vessel endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043537", "lbl" : "negative regulation of blood vessel endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043542", "lbl" : "endothelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043576", "lbl" : "regulation of respiratory gaseous exchange", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043588", "lbl" : "skin development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.", + "xrefs" : [ "GOC:jl", "UBERON:0002097" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043589", "lbl" : "skin morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.", + "xrefs" : [ "GOC:jl", "UBERON:0002097" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043603", "lbl" : "amide metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.", + "xrefs" : [ "GOC:curators" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043604", "lbl" : "amide biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.", + "xrefs" : [ "GOC:curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0043605", + "lbl" : "amide catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043931", "lbl" : "ossification involved in bone maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.", + "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:mtg_mpo" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043932", "lbl" : "ossification involved in bone remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli.", + "xrefs" : [ "GOC:mtg_mpo", "GO_REF:0000034" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0043933", "lbl" : "protein-containing complex organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044042", + "lbl" : "glucan metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044057", "lbl" : "regulation of system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044058", "lbl" : "regulation of digestive system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044060", "lbl" : "regulation of endocrine process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044062", + "lbl" : "regulation of excretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044065", "lbl" : "regulation of respiratory system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044085", "lbl" : "cellular component biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.", + "xrefs" : [ "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044087", "lbl" : "regulation of cellular component biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044088", "lbl" : "regulation of vacuole organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.", + "xrefs" : [ "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044089", "lbl" : "positive regulation of cellular component biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044090", "lbl" : "positive regulation of vacuole organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.", + "xrefs" : [ "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044091", "lbl" : "membrane biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane.", + "xrefs" : [ "GOC:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044092", + "lbl" : "negative regulation of molecular function", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.", + "xrefs" : [ "GO:jl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044093", + "lbl" : "positive regulation of molecular function", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.", + "xrefs" : [ "GO:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044207", "lbl" : "translation initiation ternary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044237", "lbl" : "cellular metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways by which individual cells transform chemical substances.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044238", "lbl" : "primary metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.", + "xrefs" : [ "GOC:go_curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Primary_metabolite" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044248", + "lbl" : "cellular catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044249", "lbl" : "cellular biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.", + "xrefs" : [ "GOC:jl" ] + }, + "comments" : [ "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044258", + "lbl" : "intestinal lipid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas.", + "xrefs" : [ "GOC:jl", "PMID:7018485" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044281", + "lbl" : "small molecule metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.", + "xrefs" : [ "GOC:curators", "GOC:pde", "GOC:vw" ] + }, + "comments" : [ "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044282", + "lbl" : "small molecule catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.", + "xrefs" : [ "GOC:curators", "GOC:vw" ] + }, + "comments" : [ "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044283", + "lbl" : "small molecule biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.", + "xrefs" : [ "GOC:curators", "GOC:pde", "GOC:vw" ] + }, + "comments" : [ "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044297", "lbl" : "cell body", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections." ], + "xrefs" : [ { + "val" : "FBbt:00005107" + }, { + "val" : "FMA:67301" + }, { + "val" : "Wikipedia:Cell_body" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044342", + "lbl" : "type B pancreatic cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin.", + "xrefs" : [ "GOC:jl", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044346", "lbl" : "fibroblast apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.", + "xrefs" : [ "CL:0000057", "GOC:jl", "GOC:mtg_apoptosis", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044380", "lbl" : "protein localization to cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044419", "lbl" : "biological process involved in interspecies interaction between organisms", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process evolved to enable an interaction with an organism of a different species.", + "xrefs" : [ "GOC:cc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044458", "lbl" : "motile cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a motile cilium.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000079", "PMID:19776033", "PMID:21129373", "ZFIN:dsf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044565", "lbl" : "dendritic cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.", + "xrefs" : [ "CL:0000451", "PMID:18469816" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044566", "lbl" : "chondrocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage.", + "xrefs" : [ "CL:0000138", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044703", "lbl" : "multi-organism reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A biological process that directly contributes to the process of producing new individuals, involving another organism.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044706", "lbl" : "multi-multicellular organism process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multicellular organism process which involves another multicellular organism of the same or different species.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044782", "lbl" : "cilium organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.", + "xrefs" : [ "GOC:cilia", "GOC:jl" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044872", "lbl" : "lipoprotein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a lipoprotein is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044873", "lbl" : "lipoprotein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044874", "lbl" : "lipoprotein localization to outer membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045026", "lbl" : "plasma membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.", + "xrefs" : [ "GOC:elh", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045124", "lbl" : "regulation of bone resorption", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045132", "lbl" : "meiotic chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.", + "xrefs" : [ "GOC:ai", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045137", "lbl" : "development of primary sexual characteristics", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045165", "lbl" : "cell fate commitment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate.", + "xrefs" : [ "ISBN:0716731185" ] + }, + "comments" : [ "Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045168", "lbl" : "cell-cell signaling involved in cell fate commitment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045184", "lbl" : "establishment of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045196", "lbl" : "establishment or maintenance of neuroblast polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.", + "xrefs" : [ "GOC:bf", "GOC:mah", "GOC:mtg_sensu", "PMID:19375318", "PMID:20066083" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045200", "lbl" : "establishment of neuroblast polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.", + "xrefs" : [ "GOC:bf", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045202", "lbl" : "synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.", + "xrefs" : [ "GOC:aruk", "ISBN:0198506732", "PMID:24619342", "PMID:29383328", "PMID:31998110" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao914572699" + }, { + "val" : "Wikipedia:Chemical_synapse" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045214", "lbl" : "sarcomere organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045216", "lbl" : "cell-cell junction organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045222", "lbl" : "CD4 biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions.", + "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045223", "lbl" : "regulation of CD4 production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045224", "lbl" : "positive regulation of CD4 production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045225", "lbl" : "negative regulation of CD4 production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045229", "lbl" : "external encapsulating structure organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045321", "lbl" : "leukocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:add" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Immunologic_activation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045444", "lbl" : "fat cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.", + "xrefs" : [ "CL:0000136", "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045445", "lbl" : "myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:go_curators", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045446", "lbl" : "endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.", + "xrefs" : [ "CL:0000115", "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045453", "lbl" : "bone resorption", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.", + "xrefs" : [ "GOC:mah", "PMID:10968780" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Bone_resorption" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045580", "lbl" : "regulation of T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of T cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045581", "lbl" : "negative regulation of T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045582", "lbl" : "positive regulation of T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of T cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045595", "lbl" : "regulation of cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045596", "lbl" : "negative regulation of cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045597", "lbl" : "positive regulation of cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045598", "lbl" : "regulation of fat cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of adipocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045599", "lbl" : "negative regulation of fat cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045600", "lbl" : "positive regulation of fat cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045601", "lbl" : "regulation of endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045602", "lbl" : "negative regulation of endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045603", "lbl" : "positive regulation of endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045604", "lbl" : "regulation of epidermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epidermal cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045605", "lbl" : "negative regulation of epidermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045606", "lbl" : "positive regulation of epidermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045619", "lbl" : "regulation of lymphocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045620", "lbl" : "negative regulation of lymphocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045621", "lbl" : "positive regulation of lymphocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + }, + "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045637", "lbl" : "regulation of myeloid cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myeloid cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045638", "lbl" : "negative regulation of myeloid cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045639", "lbl" : "positive regulation of myeloid cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045646", "lbl" : "regulation of erythrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of erythrocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045647", "lbl" : "negative regulation of erythrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045648", "lbl" : "positive regulation of erythrocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045649", "lbl" : "regulation of macrophage differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of macrophage differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045650", "lbl" : "negative regulation of macrophage differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045651", "lbl" : "positive regulation of macrophage differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of macrophage differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045652", "lbl" : "regulation of megakaryocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045653", "lbl" : "negative regulation of megakaryocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045654", "lbl" : "positive regulation of megakaryocyte differentiation", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0045655", - "lbl" : "regulation of monocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045655", + "lbl" : "regulation of monocyte differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of monocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045656", "lbl" : "negative regulation of monocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045657", "lbl" : "positive regulation of monocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of monocyte differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045661", "lbl" : "regulation of myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:go_curators", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045662", "lbl" : "negative regulation of myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:go_curators", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045663", "lbl" : "positive regulation of myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:go_curators", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045664", "lbl" : "regulation of neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuron differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045665", "lbl" : "negative regulation of neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045666", "lbl" : "positive regulation of neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuron differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045670", "lbl" : "regulation of osteoclast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of osteoclast differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045671", "lbl" : "negative regulation of osteoclast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045672", "lbl" : "positive regulation of osteoclast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045682", "lbl" : "regulation of epidermis development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epidermis development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045683", "lbl" : "negative regulation of epidermis development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045684", "lbl" : "positive regulation of epidermis development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epidermis development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045685", "lbl" : "regulation of glial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of glia cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045686", "lbl" : "negative regulation of glial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045687", "lbl" : "positive regulation of glial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of glia cell differentiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045719", + "lbl" : "negative regulation of glycogen biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045721", + "lbl" : "negative regulation of gluconeogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045722", + "lbl" : "positive regulation of gluconeogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gluconeogenesis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045724", "lbl" : "positive regulation of cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the formation of a cilium.", + "xrefs" : [ "GOC:cilia", "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045725", + "lbl" : "positive regulation of glycogen biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045727", "lbl" : "positive regulation of translation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045732", + "lbl" : "positive regulation of protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045759", "lbl" : "negative regulation of action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045760", "lbl" : "positive regulation of action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045765", "lbl" : "regulation of angiogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of angiogenesis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045766", "lbl" : "positive regulation of angiogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases angiogenesis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045769", "lbl" : "negative regulation of asymmetric cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045770", "lbl" : "positive regulation of asymmetric cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of asymmetric cell division.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045778", "lbl" : "positive regulation of ossification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045779", "lbl" : "negative regulation of bone resorption", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045780", "lbl" : "positive regulation of bone resorption", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of bone resorption.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045785", "lbl" : "positive regulation of cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell adhesion.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045786", "lbl" : "negative regulation of cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045787", "lbl" : "positive regulation of cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of progression through the cell cycle.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045806", "lbl" : "negative regulation of endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045807", "lbl" : "positive regulation of endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045818", + "lbl" : "negative regulation of glycogen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045819", + "lbl" : "positive regulation of glycogen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045822", "lbl" : "negative regulation of heart contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045823", "lbl" : "positive regulation of heart contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of heart contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045833", "lbl" : "negative regulation of lipid metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045834", "lbl" : "positive regulation of lipid metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045835", "lbl" : "negative regulation of meiotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045836", "lbl" : "positive regulation of meiotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of meiosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045839", "lbl" : "negative regulation of mitotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045840", "lbl" : "positive regulation of mitotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mitosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045843", "lbl" : "negative regulation of striated muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045844", "lbl" : "positive regulation of striated muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of striated muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045900", "lbl" : "negative regulation of translational elongation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045901", "lbl" : "positive regulation of translational elongation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of translational elongation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045904", "lbl" : "negative regulation of translational termination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045905", "lbl" : "positive regulation of translational termination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of translational termination.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045912", "lbl" : "negative regulation of carbohydrate metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045913", "lbl" : "positive regulation of carbohydrate metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045914", "lbl" : "negative regulation of catecholamine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045915", "lbl" : "positive regulation of catecholamine metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045920", "lbl" : "negative regulation of exocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045921", "lbl" : "positive regulation of exocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of exocytosis.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045926", "lbl" : "negative regulation of growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045927", "lbl" : "positive regulation of growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045930", "lbl" : "negative regulation of mitotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045931", "lbl" : "positive regulation of mitotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045932", "lbl" : "negative regulation of muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045933", "lbl" : "positive regulation of muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045934", "lbl" : "negative regulation of nucleobase-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045935", "lbl" : "positive regulation of nucleobase-containing compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045939", + "lbl" : "negative regulation of steroid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0045940", + "lbl" : "positive regulation of steroid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045947", "lbl" : "negative regulation of translational initiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045948", "lbl" : "positive regulation of translational initiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of translational initiation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045986", "lbl" : "negative regulation of smooth muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045987", "lbl" : "positive regulation of smooth muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045988", "lbl" : "negative regulation of striated muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045989", "lbl" : "positive regulation of striated muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of striated muscle contraction.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045992", "lbl" : "negative regulation of embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0045995", "lbl" : "regulation of embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of embryonic development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046013", "lbl" : "regulation of T cell homeostatic proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of resting T cell proliferation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046014", "lbl" : "negative regulation of T cell homeostatic proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046189", "lbl" : "phenol-containing compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0046394", + "lbl" : "carboxylic acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.", + "xrefs" : [ "ISBN:0198506732" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0046395", + "lbl" : "carboxylic acid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046530", "lbl" : "photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:ai", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046532", "lbl" : "regulation of photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046533", "lbl" : "negative regulation of photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046534", "lbl" : "positive regulation of photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046545", "lbl" : "development of primary female sexual characteristics", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046548", "lbl" : "retinal rod cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046549", "lbl" : "retinal cone cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046620", "lbl" : "regulation of organ growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of growth of an organ of an organism.", + "xrefs" : [ "GOC:bf", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046621", "lbl" : "negative regulation of organ growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.", + "xrefs" : [ "GOC:bf", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046622", "lbl" : "positive regulation of organ growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.", + "xrefs" : [ "GOC:bf", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046649", "lbl" : "lymphocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046651", "lbl" : "lymphocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a lymphocyte population by cell division.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046660", "lbl" : "female sex differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The establishment of the sex of a female organism by physical differentiation.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046666", "lbl" : "retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Programmed cell death that occurs in the developing retina.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046667", "lbl" : "compound eye retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium.", + "xrefs" : [ "PMID:12006672" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046668", "lbl" : "regulation of retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina.", + "xrefs" : [ "GOC:ai", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046669", "lbl" : "regulation of compound eye retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046670", "lbl" : "positive regulation of retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina.", + "xrefs" : [ "GOC:ai", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046671", "lbl" : "negative regulation of retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina.", + "xrefs" : [ "GOC:ai", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046672", "lbl" : "positive regulation of compound eye retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046673", "lbl" : "negative regulation of compound eye retinal cell programmed cell death", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0046676", + "lbl" : "negative regulation of insulin secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046716", "lbl" : "muscle cell cellular homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.", + "xrefs" : [ "GOC:mah", "PMID:3091429", "PMID:7781901" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046717", "lbl" : "acid secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of acid by a cell or a tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046785", "lbl" : "microtubule polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The addition of tubulin heterodimers to one or both ends of a microtubule.", + "xrefs" : [ "GOC:ai", "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046849", "lbl" : "bone remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.", + "xrefs" : [ "GOC:curators" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Bone_remodeling" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046850", "lbl" : "regulation of bone remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046851", "lbl" : "negative regulation of bone remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046852", "lbl" : "positive regulation of bone remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of bone remodeling.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046879", "lbl" : "hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.", + "xrefs" : [ "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046883", "lbl" : "regulation of hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046887", "lbl" : "positive regulation of hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046888", "lbl" : "negative regulation of hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046889", "lbl" : "positive regulation of lipid biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046890", "lbl" : "regulation of lipid biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046903", "lbl" : "secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled release of a substance by a cell or a tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0046907", "lbl" : "intracellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances within a cell.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0046942", + "lbl" : "carboxylic acid transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0046943", + "lbl" : "carboxylic acid transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-390347" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0047496", "lbl" : "vesicle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.", + "xrefs" : [ "GOC:ecd", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048048", "lbl" : "embryonic eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048066", "lbl" : "developmental pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.", + "xrefs" : [ "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048070", "lbl" : "regulation of developmental pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048086", "lbl" : "negative regulation of developmental pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048087", "lbl" : "positive regulation of developmental pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048103", "lbl" : "somatic stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line.", + "xrefs" : [ "GOC:jid", "ISBN:0582227089" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048132", "lbl" : "female germ-line stem cell asymmetric division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048144", "lbl" : "fibroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048145", "lbl" : "regulation of fibroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048146", "lbl" : "positive regulation of fibroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048147", "lbl" : "negative regulation of fibroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048193", "lbl" : "Golgi vesicle transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.", + "xrefs" : [ "GOC:jid", "ISBN:0716731363", "PMID:10219233" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048194", "lbl" : "Golgi vesicle budding", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The evagination of the Golgi membrane, resulting in formation of a vesicle.", + "xrefs" : [ "GOC:jid", "ISBN:0716731363", "PMID:10219233" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048199", "lbl" : "vesicle targeting, to, from or within Golgi", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation.", + "xrefs" : [ "GOC:jid", "GOC:mah", "ISBN:0716731363", "PMID:10219233" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048209", "lbl" : "regulation of vesicle targeting, to, from or within Golgi", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus.", + "xrefs" : [ "GOC:jid", "GOC:mah", "ISBN:0716731363", "PMID:10219233" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048243", "lbl" : "norepinephrine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system.", + "xrefs" : [ "GOC:ef", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048246", "lbl" : "macrophage chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a macrophage in response to an external stimulus.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048247", "lbl" : "lymphocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a lymphocyte in response to an external stimulus.", + "xrefs" : [ "GOC:hjd", "GOC:jid", "PMID:12391252" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048251", "lbl" : "elastic fiber assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching.", + "xrefs" : [ "GOC:jid", "PMID:10841810", "PMID:12615674" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048280", "lbl" : "vesicle fusion with Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048284", "lbl" : "organelle fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The creation of a single organelle from two or more organelles.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048285", "lbl" : "organelle fission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The creation of two or more organelles by division of one organelle.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048286", "lbl" : "lung alveolus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.", + "xrefs" : [ "GOC:mtg_lung", "PMID:9751757" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048288", "lbl" : "nuclear membrane fusion involved in karyogamy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048308", "lbl" : "organelle inheritance", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The partitioning of organelles between daughter cells at cell division.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048313", "lbl" : "Golgi inheritance", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The partitioning of Golgi apparatus between daughter cells at cell division.", + "xrefs" : [ "GOC:jid", "PMID:12851069" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048318", "lbl" : "axial mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048319", "lbl" : "axial mesoderm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the axial mesoderm are generated and organized.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048320", "lbl" : "axial mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048332", "lbl" : "mesoderm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the mesoderm are generated and organized.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048333", "lbl" : "mesodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048339", "lbl" : "paraxial mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048340", "lbl" : "paraxial mesoderm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the paraxial mesoderm are generated and organized.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048341", "lbl" : "paraxial mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048368", "lbl" : "lateral mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048369", "lbl" : "lateral mesoderm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the lateral mesoderm are generated and organized.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048370", "lbl" : "lateral mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048389", "lbl" : "intermediate mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048390", "lbl" : "intermediate mesoderm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the intermediate mesoderm are generated and organized.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048391", "lbl" : "intermediate mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048468", "lbl" : "cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048469", "lbl" : "cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048477", "lbl" : "oogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.", + "xrefs" : [ "GOC:kmv", "GOC:mtg_sensu", "GOC:pr" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Oogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048483", "lbl" : "autonomic nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands.", + "xrefs" : [ "FMA:9905", "GOC:jid", "GOC:sr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048485", "lbl" : "sympathetic nervous system development", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0048505", - "lbl" : "regulation of timing of cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter.", + "xrefs" : [ "FMA:9906", "GOC:jid", "GOC:sr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0048505", + "lbl" : "regulation of timing of cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development.", + "xrefs" : [ "GOC:bf", "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048513", "lbl" : "animal organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Organogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048514", "lbl" : "blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048518", "lbl" : "positive regulation of biological process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048519", "lbl" : "negative regulation of biological process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.", + "xrefs" : [ "GOC:jid" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0048520", + "lbl" : "positive regulation of behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.", + "xrefs" : [ "GOC:jid", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0048521", + "lbl" : "negative regulation of behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.", + "xrefs" : [ "GOC:jid", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048522", "lbl" : "positive regulation of cellular process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048523", "lbl" : "negative regulation of cellular process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048534", "lbl" : "hematopoietic or lymphoid organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.", + "xrefs" : [ "GOC:add", "GOC:rl", "ISBN:0781735149" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0048536", + "lbl" : "spleen development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048539", "lbl" : "bone marrow development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:add", "ISBN:0781735149" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048545", "lbl" : "response to steroid hormone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048546", "lbl" : "digestive tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.", + "xrefs" : [ "GOC:dph", "GOC:go_curators", "PMID:12618131" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048562", "lbl" : "embryonic organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048565", "lbl" : "digestive tract development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048568", "lbl" : "embryonic organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048570", "lbl" : "notochord morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048580", "lbl" : "regulation of post-embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048581", "lbl" : "negative regulation of post-embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048582", "lbl" : "positive regulation of post-embryonic development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048583", "lbl" : "regulation of response to stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.", + "xrefs" : [ "GOC:jid" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048584", "lbl" : "positive regulation of response to stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.", + "xrefs" : [ "GOC:jid" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048585", "lbl" : "negative regulation of response to stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.", + "xrefs" : [ "GOC:jid" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048588", "lbl" : "developmental cell growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.", + "xrefs" : [ "GOC:go_curators", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048589", "lbl" : "developmental growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048592", "lbl" : "eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the eye are generated and organized.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048593", "lbl" : "camera-type eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048596", "lbl" : "embryonic camera-type eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the eye are generated and organized during embryonic development.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048598", "lbl" : "embryonic morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048599", "lbl" : "oocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048601", "lbl" : "oocyte morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048608", "lbl" : "reproductive structure development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048609", "lbl" : "multicellular organismal reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048627", "lbl" : "myoblast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:dph", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048628", "lbl" : "myoblast maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:dph", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048630", "lbl" : "skeletal muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size.", + "xrefs" : [ "GOC:lm", "PMID:15726494", "PMID:15907921" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048631", "lbl" : "regulation of skeletal muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle growth.", + "xrefs" : [ "GOC:lm", "PMID:15726494", "PMID:15907921" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048632", "lbl" : "negative regulation of skeletal muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth.", + "xrefs" : [ "GOC:lm", "PMID:15726494", "PMID:15907921" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048633", "lbl" : "positive regulation of skeletal muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of skeletal muscle growth.", + "xrefs" : [ "GOC:lm", "PMID:15726494", "PMID:15907921" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048634", "lbl" : "regulation of muscle organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048635", "lbl" : "negative regulation of muscle organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048636", "lbl" : "positive regulation of muscle organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of muscle development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048638", "lbl" : "regulation of developmental growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of developmental growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048639", "lbl" : "positive regulation of developmental growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of developmental growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048640", "lbl" : "negative regulation of developmental growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048641", "lbl" : "regulation of skeletal muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048642", "lbl" : "negative regulation of skeletal muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048643", "lbl" : "positive regulation of skeletal muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of skeletal muscle tissue development.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048644", "lbl" : "muscle organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of muscle are generated and organized.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048645", "lbl" : "animal organ formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048646", "lbl" : "anatomical structure formation involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ] + }, + "comments" : [ "Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048659", "lbl" : "smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.", + "xrefs" : [ "CL:0000192", "GOC:ebc", "PMID:1840698" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048660", "lbl" : "regulation of smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.", + "xrefs" : [ "CL:0000192", "GOC:ebc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048661", "lbl" : "positive regulation of smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of smooth muscle cell proliferation.", + "xrefs" : [ "CL:0000192", "GOC:ebc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048662", "lbl" : "negative regulation of smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.", + "xrefs" : [ "CL:0000192", "GOC:ebc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048666", "lbl" : "neuron development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048667", "lbl" : "cell morphogenesis involved in neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048699", "lbl" : "generation of neurons", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.", + "xrefs" : [ "GOC:nln" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048705", "lbl" : "skeletal system morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the skeleton are generated and organized.", + "xrefs" : [ "GOC:dph", "GOC:dsf", "GOC:jid", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048729", "lbl" : "tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a tissue are generated and organized.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048730", "lbl" : "epidermis morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.", + "xrefs" : [ "GOC:jid", "UBERON:0001003" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048731", "lbl" : "system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048732", "lbl" : "gland development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048736", "lbl" : "appendage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.", + "xrefs" : [ "GOC:jid", "GOC:rc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048738", "lbl" : "cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:lm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048741", "lbl" : "skeletal muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.", + "xrefs" : [ "GOC:dph", "GOC:ef", "GOC:jid", "GOC:lm", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048742", "lbl" : "regulation of skeletal muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:mtg_muscle", "GOC:sm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048743", "lbl" : "positive regulation of skeletal muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:lm", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048744", "lbl" : "negative regulation of skeletal muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:lm", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048745", "lbl" : "smooth muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:lm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048749", "lbl" : "compound eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.", + "xrefs" : [ "GOC:jid", "GOC:mtg_sensu", "Wikipedia:Eye" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048753", "lbl" : "pigment granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule.", + "xrefs" : [ "GOC:rc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048754", "lbl" : "branching morphogenesis of an epithelial tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.", + "xrefs" : [ "GOC:dgh", "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048755", "lbl" : "branching morphogenesis of a nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).", + "xrefs" : [ "GOC:dgh", "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048762", "lbl" : "mesenchymal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048770", "lbl" : "pigment granule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes.", + "xrefs" : [ "GOC:jid", "GOC:mh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048771", "lbl" : "tissue remodeling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.", + "xrefs" : [ "GOC:ebc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048799", "lbl" : "animal organ maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048806", "lbl" : "genitalia development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048812", "lbl" : "neuron projection morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048821", "lbl" : "erythrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048823", "lbl" : "nucleate erythrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048844", "lbl" : "artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.", + "xrefs" : [ "GOC:dsf", "PMID:16740480" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048845", "lbl" : "venous blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart.", + "xrefs" : [ "GOC:dsf", "PMID:16740480" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048854", "lbl" : "brain morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).", + "xrefs" : [ "GOC:dgh", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048856", "lbl" : "anatomical structure development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.", + "xrefs" : [ "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048857", "lbl" : "neural nucleus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma.", + "xrefs" : [ "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048858", "lbl" : "cell projection morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a cell projection are generated and organized.", + "xrefs" : [ "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048859", "lbl" : "formation of anatomical boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.", + "xrefs" : [ "GO_REF:0000021" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048863", "lbl" : "stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.", + "xrefs" : [ "CL:0000034", "GOC:isa_complete" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Stem_cell_differentiation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048864", "lbl" : "stem cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate.", + "xrefs" : [ "CL:0000034", "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048869", "lbl" : "cellular developmental process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048870", "lbl" : "cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.", + "xrefs" : [ "GOC:dgh", "GOC:dph", "GOC:isa_complete", "GOC:mlg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048871", "lbl" : "multicellular organismal-level homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048872", "lbl" : "homeostasis of number of cells", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048873", "lbl" : "homeostasis of number of cells within a tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.", + "xrefs" : [ "GOC:isa_complete" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0048878", + "lbl" : "chemical homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of an internal steady state of a chemical.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048880", "lbl" : "sensory system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048934", "lbl" : "peripheral nervous system neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0048935", "lbl" : "peripheral nervous system neuron development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.", + "xrefs" : [ "GOC:dgh" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050000", "lbl" : "chromosome localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a chromosome is transported to, or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050432", "lbl" : "catecholamine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.", + "xrefs" : [ "GOC:ai", "GOC:ef" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050433", "lbl" : "regulation of catecholamine secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050658", "lbl" : "RNA transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050670", "lbl" : "regulation of lymphocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphocyte proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050671", "lbl" : "positive regulation of lymphocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of lymphocyte proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050672", "lbl" : "negative regulation of lymphocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050673", "lbl" : "epithelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.", + "xrefs" : [ "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050678", "lbl" : "regulation of epithelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial cell proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050679", "lbl" : "positive regulation of epithelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of epithelial cell proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050680", "lbl" : "negative regulation of epithelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050708", "lbl" : "regulation of protein secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050709", "lbl" : "negative regulation of protein secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050714", "lbl" : "positive regulation of protein secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050727", "lbl" : "regulation of inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050728", "lbl" : "negative regulation of inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050729", "lbl" : "positive regulation of inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the inflammatory response.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050746", "lbl" : "regulation of lipoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050747", "lbl" : "positive regulation of lipoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050748", "lbl" : "negative regulation of lipoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050764", "lbl" : "regulation of phagocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050765", "lbl" : "negative regulation of phagocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050766", "lbl" : "positive regulation of phagocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of phagocytosis.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050767", "lbl" : "regulation of neurogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050768", "lbl" : "negative regulation of neurogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050769", "lbl" : "positive regulation of neurogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050776", "lbl" : "regulation of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050777", "lbl" : "negative regulation of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050778", "lbl" : "positive regulation of immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050789", "lbl" : "regulation of biological process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.", + "xrefs" : [ "GOC:ai", "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050790", + "lbl" : "regulation of catalytic activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the activity of an enzyme.", + "xrefs" : [ "GOC:ai", "GOC:ebc", "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050793", "lbl" : "regulation of developmental process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050794", "lbl" : "regulation of cellular process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.", + "xrefs" : [ "GOC:go_curators" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050795", + "lbl" : "regulation of behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.", + "xrefs" : [ "GOC:go_curators", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050796", + "lbl" : "regulation of insulin secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of insulin.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050801", + "lbl" : "monoatomic ion homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050803", "lbl" : "regulation of synapse structure or activity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050804", "lbl" : "modulation of chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050805", "lbl" : "negative regulation of synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050806", "lbl" : "positive regulation of synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050807", "lbl" : "regulation of synapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050808", "lbl" : "synapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).", + "xrefs" : [ "GOC:ai", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050810", + "lbl" : "regulation of steroid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050832", "lbl" : "defense response to fungus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050863", "lbl" : "regulation of T cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of T cell activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050865", "lbl" : "regulation of cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050866", "lbl" : "negative regulation of cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050867", "lbl" : "positive regulation of cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050868", "lbl" : "negative regulation of T cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050870", "lbl" : "positive regulation of T cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of T cell activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050877", "lbl" : "nervous system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A organ system process carried out by any of the organs or tissues of neurological system.", + "xrefs" : [ "GOC:ai", "GOC:mtg_cardio" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050878", + "lbl" : "regulation of body fluid levels", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the levels of body fluids.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050879", "lbl" : "multicellular organismal movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism.", + "xrefs" : [ "GOC:dph", "GOC:mtg_muscle", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050881", "lbl" : "musculoskeletal movement", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7227" - } ] + "definition" : { + "val" : "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.", + "xrefs" : [ "GOC:dph" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050886", "lbl" : "endocrine process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.", + "xrefs" : [ "ISBN:0721662544" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050890", + "lbl" : "cognition", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.", + "xrefs" : [ "ISBN:0721619908" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Cognition" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050896", "lbl" : "response to stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.", + "xrefs" : [ "GOC:ai", "GOC:bf" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050900", "lbl" : "leukocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a leukocyte within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:14680625", "PMID:14708592", "PMID:7507411", "PMID:8600538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050905", "lbl" : "neuromuscular process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process pertaining to the functions of the nervous and muscular systems of an organism.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050906", "lbl" : "detection of stimulus involved in sensory perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal.", + "xrefs" : [ "GOC:ai", "GOC:dos", "GOC:dph" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Transduction_(physiology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050907", "lbl" : "detection of chemical stimulus involved in sensory perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception.", + "xrefs" : [ "GOC:ai", "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050908", "lbl" : "detection of light stimulus involved in visual perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.", + "xrefs" : [ "GOC:ai", "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050920", "lbl" : "regulation of chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050921", "lbl" : "positive regulation of chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050922", "lbl" : "negative regulation of chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050931", "lbl" : "pigment cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte.", + "xrefs" : [ "GOC:dgh" ] + }, + "comments" : [ "Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050932", "lbl" : "regulation of pigment cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of pigmented cell differentiation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050941", "lbl" : "negative regulation of pigment cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050942", "lbl" : "positive regulation of pigment cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050953", "lbl" : "sensory perception of light stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050954", "lbl" : "sensory perception of mechanical stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050962", "lbl" : "detection of light stimulus involved in sensory perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light.", + "xrefs" : [ "GOC:ai", "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050968", "lbl" : "detection of chemical stimulus involved in sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0050975", "lbl" : "sensory perception of touch", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Touch" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050994", + "lbl" : "regulation of lipid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050995", + "lbl" : "negative regulation of lipid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0050996", + "lbl" : "positive regulation of lipid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051017", "lbl" : "actin filament bundle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051027", "lbl" : "DNA transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051033", + "lbl" : "RNA transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-203906" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051035", + "lbl" : "DNA transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051046", "lbl" : "regulation of secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051047", "lbl" : "positive regulation of secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051048", "lbl" : "negative regulation of secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051049", "lbl" : "regulation of transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051050", "lbl" : "positive regulation of transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051051", "lbl" : "negative regulation of transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051052", "lbl" : "regulation of DNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051053", "lbl" : "negative regulation of DNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051054", "lbl" : "positive regulation of DNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051055", "lbl" : "negative regulation of lipid biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051078", "lbl" : "meiotic nuclear membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs.", + "xrefs" : [ "GOC:bf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051081", "lbl" : "nuclear membrane disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The controlled breakdown of the nuclear membranes, for example during cellular division.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051093", "lbl" : "negative regulation of developmental process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051094", "lbl" : "positive regulation of developmental process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051128", "lbl" : "regulation of cellular component organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051129", "lbl" : "negative regulation of cellular component organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051130", "lbl" : "positive regulation of cellular component organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051145", "lbl" : "smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.", + "xrefs" : [ "CL:0000192", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051146", "lbl" : "striated muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.", + "xrefs" : [ "CL:0000737", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051147", "lbl" : "regulation of muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle cell differentiation.", + "xrefs" : [ "CL:0000187", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051148", "lbl" : "negative regulation of muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation.", + "xrefs" : [ "CL:0000187", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051149", "lbl" : "positive regulation of muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.", + "xrefs" : [ "CL:0000187", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051150", "lbl" : "regulation of smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.", + "xrefs" : [ "CL:0000192", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051151", "lbl" : "negative regulation of smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation.", + "xrefs" : [ "CL:0000192", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051152", "lbl" : "positive regulation of smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation.", + "xrefs" : [ "CL:0000192", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051153", "lbl" : "regulation of striated muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation.", + "xrefs" : [ "CL:0000737", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051154", "lbl" : "negative regulation of striated muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation.", + "xrefs" : [ "CL:0000737", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051155", "lbl" : "positive regulation of striated muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.", + "xrefs" : [ "CL:0000737", "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051169", "lbl" : "nuclear transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances into, out of, or within the nucleus.", + "xrefs" : [ "GOC:ai" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Nuclear_transport" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051179", "lbl" : "localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.", + "xrefs" : [ "GOC:ai", "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051216", "lbl" : "cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:cjm", "PMID:23251424" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Chondrogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051222", "lbl" : "positive regulation of protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051223", "lbl" : "regulation of protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051224", "lbl" : "negative regulation of protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051234", "lbl" : "establishment of localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.", + "xrefs" : [ "GOC:ai", "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051236", "lbl" : "establishment of RNA localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of RNA to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051239", "lbl" : "regulation of multicellular organismal process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051240", "lbl" : "positive regulation of multicellular organismal process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051241", "lbl" : "negative regulation of multicellular organismal process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051246", "lbl" : "regulation of protein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051247", "lbl" : "positive regulation of protein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051248", "lbl" : "negative regulation of protein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051249", "lbl" : "regulation of lymphocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphocyte activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051250", "lbl" : "negative regulation of lymphocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051251", "lbl" : "positive regulation of lymphocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphocyte activation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051252", "lbl" : "regulation of RNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051253", "lbl" : "negative regulation of RNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051254", "lbl" : "positive regulation of RNA metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051258", "lbl" : "protein polymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051261", "lbl" : "protein depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051276", "lbl" : "chromosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051301", "lbl" : "cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.", + "xrefs" : [ "GOC:di", "GOC:go_curators", "GOC:pr" ] + }, + "comments" : [ "Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division." ], + "xrefs" : [ { + "val" : "Wikipedia:Cell_division" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051302", "lbl" : "regulation of cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.", + "xrefs" : [ "GOC:go_curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051303", "lbl" : "establishment of chromosome localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a chromosome to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051321", "lbl" : "meiotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.", + "xrefs" : [ "GOC:ai" ] + }, + "comments" : [ "Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle." ], + "xrefs" : [ { + "val" : "Wikipedia:Meiosis" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051336", + "lbl" : "regulation of hydrolase activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051345", + "lbl" : "positive regulation of hydrolase activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.", + "xrefs" : [ "GOC:ai" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051346", + "lbl" : "negative regulation of hydrolase activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051402", "lbl" : "neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.", + "xrefs" : [ "CL:0000540", "GOC:mtg_apoptosis" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0051410", + "lbl" : "detoxification of nitrogen compound", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051445", "lbl" : "regulation of meiotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of progression through the meiotic cell cycle.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051446", "lbl" : "positive regulation of meiotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051447", "lbl" : "negative regulation of meiotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051450", "lbl" : "myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:ai", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051451", "lbl" : "myoblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.", + "xrefs" : [ "CL:0000056", "GOC:ai", "GOC:mtg_muscle" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051469", "lbl" : "vesicle fusion with vacuole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051493", "lbl" : "regulation of cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051494", "lbl" : "negative regulation of cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051495", "lbl" : "positive regulation of cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051606", "lbl" : "detection of stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal.", + "xrefs" : [ "GOC:add", "GOC:ai", "GOC:dph", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051620", "lbl" : "norepinephrine uptake", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051621", "lbl" : "regulation of norepinephrine uptake", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051622", "lbl" : "negative regulation of norepinephrine uptake", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051623", "lbl" : "positive regulation of norepinephrine uptake", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051640", "lbl" : "organelle localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which an organelle is transported to, and/or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051641", "lbl" : "cellular localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.", + "xrefs" : [ "GOC:tb", "GOC:vw" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051645", "lbl" : "Golgi localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051647", "lbl" : "nucleus localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051648", "lbl" : "vesicle localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051649", "lbl" : "establishment of localization in cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.", + "xrefs" : [ "GOC:ai", "GOC:dos", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051650", "lbl" : "establishment of vesicle localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a vesicle to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051656", "lbl" : "establishment of organelle localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of an organelle to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051668", "lbl" : "localization within membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051674", "lbl" : "localization of cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a cell is transported to, and/or maintained in, a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051683", "lbl" : "establishment of Golgi localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of the Golgi to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051707", "lbl" : "response to other organism", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051716", "lbl" : "cellular response to stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.", + "xrefs" : [ "GOC:bf", "GOC:jl" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051726", "lbl" : "regulation of cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of progression through the cell cycle.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051781", "lbl" : "positive regulation of cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell division.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051782", "lbl" : "negative regulation of cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051783", "lbl" : "regulation of nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051784", "lbl" : "negative regulation of nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051785", "lbl" : "positive regulation of nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051875", "lbl" : "pigment granule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051890", "lbl" : "regulation of cardioblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051891", "lbl" : "positive regulation of cardioblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051892", "lbl" : "negative regulation of cardioblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051904", "lbl" : "pigment granule transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051905", "lbl" : "establishment of pigment granule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a pigment granule to a specific location.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051930", "lbl" : "regulation of sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051931", "lbl" : "regulation of sensory perception", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051937", "lbl" : "catecholamine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.", + "xrefs" : [ "GOC:ai", "ISBN:0198506732" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051952", "lbl" : "regulation of amine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051953", "lbl" : "negative regulation of amine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051954", "lbl" : "positive regulation of amine transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051960", "lbl" : "regulation of nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051961", "lbl" : "negative regulation of nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051962", "lbl" : "positive regulation of nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051963", "lbl" : "regulation of synapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.", + "xrefs" : [ "GOC:ai", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051964", "lbl" : "negative regulation of synapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.", + "xrefs" : [ "GOC:ai", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051965", "lbl" : "positive regulation of synapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.", + "xrefs" : [ "GOC:ai", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051969", "lbl" : "regulation of transmission of nerve impulse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051970", "lbl" : "negative regulation of transmission of nerve impulse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051971", "lbl" : "positive regulation of transmission of nerve impulse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051983", "lbl" : "regulation of chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051984", "lbl" : "positive regulation of chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0051985", "lbl" : "negative regulation of chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.", + "xrefs" : [ "GOC:ai" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055001", "lbl" : "muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.", + "xrefs" : [ "CL:0000187", "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055002", "lbl" : "striated muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.", + "xrefs" : [ "CL:0000737", "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055003", "lbl" : "cardiac myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055006", "lbl" : "cardiac cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055007", "lbl" : "cardiac muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.", + "xrefs" : [ "GOC:devbiol", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055008", "lbl" : "cardiac muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of cardiac muscle tissue are generated and organized.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055009", "lbl" : "atrial cardiac muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of cardiac atrium muscle is generated and organized.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055010", "lbl" : "ventricular cardiac muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055013", "lbl" : "cardiac muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.", + "xrefs" : [ "GOC:devbiol", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055017", "lbl" : "cardiac muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.", + "xrefs" : [ "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055018", "lbl" : "regulation of cardiac muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055019", "lbl" : "negative regulation of cardiac muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055020", "lbl" : "positive regulation of cardiac muscle fiber development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055021", "lbl" : "regulation of cardiac muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle growth.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055022", "lbl" : "negative regulation of cardiac muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055023", "lbl" : "positive regulation of cardiac muscle tissue growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055024", "lbl" : "regulation of cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055025", "lbl" : "positive regulation of cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055026", "lbl" : "negative regulation of cardiac muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development.", + "xrefs" : [ "GOC:vk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055057", "lbl" : "neuroblast division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron.", + "xrefs" : [ "PMID:11163136", "PMID:11250167" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055059", "lbl" : "asymmetric neuroblast division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0055082", + "lbl" : "intracellular chemical homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell.", + "xrefs" : [ "GOC:isa_complete", "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055085", "lbl" : "transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.", + "xrefs" : [ "GOC:dph", "GOC:jid" ] + }, + "comments" : [ "Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0055088", + "lbl" : "lipid homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055094", "lbl" : "response to lipoprotein particle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055107", "lbl" : "Golgi to secretory granule transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055108", "lbl" : "Golgi to transport vesicle transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis.", + "xrefs" : [ "GOC:jid" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055117", "lbl" : "regulation of cardiac muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle contraction.", + "xrefs" : [ "GOC:ecd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055118", "lbl" : "negative regulation of cardiac muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.", + "xrefs" : [ "GOC:ecd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0055123", "lbl" : "digestive system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:jid" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060021", + "lbl" : "roof of mouth development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.", + "xrefs" : [ "GOC:dph", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060037", "lbl" : "pharyngeal system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060038", "lbl" : "cardiac muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a cardiac muscle cell population by cell division.", + "xrefs" : [ "GOC:dph", "GOC:rph", "PMID:11161571" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060039", "lbl" : "pericardium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery.", + "xrefs" : [ "GOC:dph", "GOC:rph", "PMID:15138308", "PMID:16376438" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060041", "lbl" : "retina development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.", + "xrefs" : [ "GOC:bf", "GOC:dph", "ISBN:0815340729" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060042", "lbl" : "retina morphogenesis in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the retina is generated and organized.", + "xrefs" : [ "GOC:bf", "GOC:dph", "GOC:mtg_sensu" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060043", "lbl" : "regulation of cardiac muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:rph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060044", "lbl" : "negative regulation of cardiac muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:rph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060045", "lbl" : "positive regulation of cardiac muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:rph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060047", "lbl" : "heart contraction", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0060048", - "lbl" : "cardiac muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060048", + "lbl" : "cardiac muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle contraction of cardiac muscle tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060136", "lbl" : "embryonic process involved in female pregnancy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060142", "lbl" : "regulation of syncytium formation by plasma membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060143", "lbl" : "positive regulation of syncytium formation by plasma membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060170", "lbl" : "ciliary membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the plasma membrane surrounding a cilium.", + "xrefs" : [ "GOC:cilia", "GOC:dph", "GOC:rph" ] + }, + "comments" : [ "Note that cilia and eukaryotic flagella are deemed to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060173", "lbl" : "limb development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.", + "xrefs" : [ "GOC:dgh", "GOC:dph", "PMID:11487378" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Limb_development" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060214", "lbl" : "endocardium formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:bf", "GOC:dph", "PMID:17722983" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060218", "lbl" : "hematopoietic stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.", + "xrefs" : [ "GOC:BHF", "GOC:bf", "GOC:dph", "GOC:rl", "PMID:15378083" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060219", "lbl" : "camera-type eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060221", "lbl" : "retinal rod cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060231", "lbl" : "mesenchymal to epithelial transition", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060249", "lbl" : "anatomical structure homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060251", "lbl" : "regulation of glial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of glial cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060252", "lbl" : "positive regulation of glial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of glial cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:sl", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060253", "lbl" : "negative regulation of glial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or decreases the rate or extent of glial cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:sl", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060255", "lbl" : "regulation of macromolecule metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060271", "lbl" : "cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.", + "xrefs" : [ "GOC:BHF", "GOC:cilia", "GOC:dph", "GOC:kmv", "GOC:pr", "GOC:vw", "ISBN:0198506732", "PMID:13978319", "PMID:27350441" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060281", "lbl" : "regulation of oocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dph", "GOC:tb", "PMID:2394318" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060282", "lbl" : "positive regulation of oocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060283", "lbl" : "negative regulation of oocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060284", "lbl" : "regulation of cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060285", "lbl" : "cilium-dependent cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.", + "xrefs" : [ "GOC:cilia", "GOC:dgh", "GOC:dph", "GOC:krc", "GOC:mlg", "GOC:mtg_cambridge_2013" ] + }, + "comments" : [ "Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060294", "lbl" : "cilium movement involved in cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Movement of cilia mediated by motor proteins that contributes to the movement of a cell.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060295", "lbl" : "regulation of cilium movement involved in cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060297", "lbl" : "regulation of sarcomere organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060298", "lbl" : "positive regulation of sarcomere organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060299", "lbl" : "negative regulation of sarcomere organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060322", "lbl" : "head development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060323", "lbl" : "head morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060324", "lbl" : "face development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060325", "lbl" : "face morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060326", "lbl" : "cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060341", "lbl" : "regulation of cellular localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060343", + "lbl" : "trabecula formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060344", + "lbl" : "liver trabecula formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060345", + "lbl" : "spleen trabecula formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060347", + "lbl" : "heart trabecula formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060348", "lbl" : "bone development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060349", "lbl" : "bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which bones are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060350", "lbl" : "endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone.", + "xrefs" : [ "GOC:dph", "PMID:11680679" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060351", "lbl" : "cartilage development involved in endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060359", "lbl" : "response to ammonium ion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:23509267" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060379", "lbl" : "cardiac muscle cell myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060404", "lbl" : "axonemal microtubule depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules.", + "xrefs" : [ "GOC:cilia", "GOC:dph", "GOC:krc", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060411", "lbl" : "cardiac septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060412", "lbl" : "ventricular septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060413", "lbl" : "atrial septum morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060414", "lbl" : "aorta smooth muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.", + "xrefs" : [ "GOC:bf", "GOC:dgh", "GOC:dph", "Wikipedia:Aorta" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060415", "lbl" : "muscle tissue morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060419", "lbl" : "heart growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of the heart.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060420", "lbl" : "regulation of heart growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060421", "lbl" : "positive regulation of heart growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060425", "lbl" : "lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the lung are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060426", "lbl" : "lung vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060427", "lbl" : "lung connective tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060428", "lbl" : "lung epithelium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060429", "lbl" : "epithelium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060431", "lbl" : "primary lung bud formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060433", "lbl" : "bronchus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060434", "lbl" : "bronchus morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060435", "lbl" : "bronchiole development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060436", "lbl" : "bronchiole morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060437", "lbl" : "lung growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060438", "lbl" : "trachea development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060439", "lbl" : "trachea morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060440", "lbl" : "trachea formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060441", "lbl" : "epithelial tube branching involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060450", + "lbl" : "positive regulation of hindgut contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060451", + "lbl" : "negative regulation of hindgut contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060452", "lbl" : "positive regulation of cardiac muscle contraction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of cardiac muscle contraction.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060453", "lbl" : "regulation of gastric acid secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060454", "lbl" : "positive regulation of gastric acid secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060455", "lbl" : "negative regulation of gastric acid secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060456", "lbl" : "positive regulation of digestive system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060457", "lbl" : "negative regulation of digestive system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060458", "lbl" : "right lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060459", "lbl" : "left lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060460", "lbl" : "left lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which anatomical structures of the left lung are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060461", "lbl" : "right lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which anatomical structures of the right lung are generated and organized.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060462", "lbl" : "lung lobe development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060463", "lbl" : "lung lobe morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060464", "lbl" : "lung lobe formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060465", "lbl" : "pharynx development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.", + "xrefs" : [ "GOC:dph", "GOC:rk" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060467", "lbl" : "negative regulation of fertilization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060468", "lbl" : "prevention of polyspermy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060479", "lbl" : "lung cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060485", "lbl" : "mesenchyme development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060486", "lbl" : "club cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung", "PMID:28144783" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060487", "lbl" : "lung epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060491", "lbl" : "regulation of cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of cell projection assembly.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060495", "lbl" : "cell-cell signaling involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060496", "lbl" : "mesenchymal-epithelial cell signaling involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060497", "lbl" : "mesenchymal-endodermal cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060501", "lbl" : "positive regulation of epithelial cell proliferation involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060502", "lbl" : "epithelial cell proliferation involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060509", "lbl" : "type I pneumocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060510", "lbl" : "type II pneumocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung", "ISBN:0721662544" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060532", "lbl" : "bronchus cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060533", "lbl" : "bronchus cartilage morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060534", "lbl" : "trachea cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060535", "lbl" : "trachea cartilage morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of cartilage in the trachea are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060536", "lbl" : "cartilage morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of cartilage are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060537", "lbl" : "muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060538", "lbl" : "skeletal muscle organ development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060539", "lbl" : "diaphragm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060540", "lbl" : "diaphragm morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the diaphragm are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060541", "lbl" : "respiratory system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060560", "lbl" : "developmental growth involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060561", "lbl" : "apoptotic process involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that contributes to the shaping of an anatomical structure.", + "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060562", "lbl" : "epithelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060563", "lbl" : "neuroepithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which epiblast cells acquire specialized features of neuroepithelial cells.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060571", "lbl" : "morphogenesis of an epithelial fold", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which an epithelial sheet bends along a linear axis.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060572", "lbl" : "morphogenesis of an epithelial bud", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060574", + "lbl" : "intestinal epithelial cell maturation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus.", + "xrefs" : [ "GOC:dph", "PMID:18824147" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060575", + "lbl" : "intestinal epithelial cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0060576", + "lbl" : "intestinal epithelial cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060577", "lbl" : "pulmonary vein morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060578", "lbl" : "superior vena cava morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060581", "lbl" : "cell fate commitment involved in pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060591", "lbl" : "chondroblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060612", "lbl" : "adipose tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060623", "lbl" : "regulation of chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060627", "lbl" : "regulation of vesicle-mediated transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060632", "lbl" : "regulation of microtubule-based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060638", "lbl" : "mesenchymal-epithelial cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060684", "lbl" : "epithelial-mesenchymal cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060688", "lbl" : "regulation of morphogenesis of a branching structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060784", "lbl" : "regulation of cell proliferation involved in tissue homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060785", "lbl" : "regulation of apoptosis involved in tissue homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060786", "lbl" : "regulation of cell differentiation involved in tissue homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060788", "lbl" : "ectodermal placode formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060795", "lbl" : "cell fate commitment involved in formation of primary germ layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060837", "lbl" : "blood vessel endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060840", "lbl" : "artery development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060841", "lbl" : "venous blood vessel development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060842", "lbl" : "arterial endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060843", "lbl" : "venous endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060896", "lbl" : "neural plate pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060897", "lbl" : "neural plate regionalization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060900", "lbl" : "embryonic camera-type eye formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape.", + "xrefs" : [ "GOC:dph", "GOC:sdb_2009", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060907", "lbl" : "positive regulation of macrophage cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060914", "lbl" : "heart formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060915", "lbl" : "mesenchymal cell differentiation involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060916", "lbl" : "mesenchymal cell proliferation involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060920", "lbl" : "cardiac pacemaker cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.", + "xrefs" : [ "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060921", "lbl" : "sinoatrial node cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060922", "lbl" : "atrioventricular node cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060926", "lbl" : "cardiac pacemaker cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.", + "xrefs" : [ "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060928", "lbl" : "atrioventricular node cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060931", "lbl" : "sinoatrial node cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060932", "lbl" : "His-Purkinje system cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060933", "lbl" : "His-Purkinje system cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060935", "lbl" : "cardiac fibroblast cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060936", "lbl" : "cardiac fibroblast cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060945", "lbl" : "cardiac neuron differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060946", "lbl" : "cardiac blood vessel endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060950", "lbl" : "cardiac glial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060952", "lbl" : "cardiac glial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060956", "lbl" : "endocardial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060958", "lbl" : "endocardial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060959", "lbl" : "cardiac neuron development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060973", "lbl" : "cell migration involved in heart development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060974", "lbl" : "cell migration involved in heart formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060976", "lbl" : "coronary vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060977", "lbl" : "coronary vasculature morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060978", "lbl" : "angiogenesis involved in coronary vascular morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060979", "lbl" : "vasculogenesis involved in coronary vascular morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060980", "lbl" : "cell migration involved in coronary vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060981", "lbl" : "cell migration involved in coronary angiogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels.", + "xrefs" : [ "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0060986", "lbl" : "endocrine hormone secretion", - "type" : "CLASS" - }, { + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of a hormone into the circulatory system.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061007", + "lbl" : "hepaticobiliary system process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061008", + "lbl" : "hepaticobiliary system development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061009", + "lbl" : "common bile duct development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine.", + "xrefs" : [ "PMID:20614624" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061010", + "lbl" : "gallbladder development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061011", + "lbl" : "hepatic duct development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct.", + "xrefs" : [ "GOC:dph", "PMID:20614624" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061017", + "lbl" : "hepatoblast differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes.", + "xrefs" : [ "GOC:dph", "PMID:15226394" ] + } + } + }, { "id" : "http://purl.obolibrary.org/obo/GO_0061024", "lbl" : "membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061025", "lbl" : "membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The membrane organization process that joins two lipid bilayers to form a single membrane.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Lipid_bilayer_fusion" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061032", "lbl" : "visceral serous pericardium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061035", "lbl" : "regulation of cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061036", "lbl" : "positive regulation of cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061037", "lbl" : "negative regulation of cartilage development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061040", "lbl" : "female gonad morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a female gonad is generated and organized.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061046", "lbl" : "regulation of branching involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061047", "lbl" : "positive regulation of branching involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061048", "lbl" : "negative regulation of branching involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061049", "lbl" : "cell growth involved in cardiac muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061050", "lbl" : "regulation of cell growth involved in cardiac muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061051", "lbl" : "positive regulation of cell growth involved in cardiac muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061052", "lbl" : "negative regulation of cell growth involved in cardiac muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061053", "lbl" : "somite development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061054", "lbl" : "dermatome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061055", "lbl" : "myotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061056", "lbl" : "sclerotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061061", "lbl" : "muscle structure development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061072", "lbl" : "iris morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061073", "lbl" : "ciliary body morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061074", "lbl" : "regulation of neural retina development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061075", "lbl" : "positive regulation of neural retina development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061076", "lbl" : "negative regulation of neural retina development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061080", "lbl" : "right horn of sinus venosus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the right horn of the sinus venosus from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061081", "lbl" : "positive regulation of myeloid leukocyte cytokine production involved in immune response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061082", "lbl" : "myeloid leukocyte cytokine production", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that contributes to cytokine production by a myeloid cell.", + "xrefs" : [ "GOC:dph" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061100", "lbl" : "lung neuroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium.", + "xrefs" : [ "GOC:dph", "PMID:9126746" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061101", "lbl" : "neuroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061102", "lbl" : "stomach neuroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium.", + "xrefs" : [ "GOC:dph", "PMID:18173746" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061105", "lbl" : "regulation of stomach neuroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061106", "lbl" : "negative regulation of stomach neuroendocrine cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061109", "lbl" : "dense core granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061111", "lbl" : "epithelial-mesenchymal cell signaling involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061113", + "lbl" : "pancreas morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061114", + "lbl" : "branching involved in pancreas morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the branches of the pancreas are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061117", "lbl" : "negative regulation of heart growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.", + "xrefs" : [ "GOC:dph", "GOC:hjd" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061130", + "lbl" : "pancreatic bud formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061138", "lbl" : "morphogenesis of a branching epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a branched epithelium are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061140", "lbl" : "lung secretory cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061141", "lbl" : "lung ciliated cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells.", + "xrefs" : [ "GOC:cilia", "GOC:dph", "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061147", "lbl" : "endocardial endothelium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061148", "lbl" : "extracellular matrix organization involved in endocardium development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061152", "lbl" : "trachea submucosa development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061153", + "lbl" : "trachea gland development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061154", "lbl" : "endothelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061155", "lbl" : "pulmonary artery endothelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061156", "lbl" : "pulmonary artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061178", + "lbl" : "regulation of insulin secretion involved in cellular response to glucose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061179", + "lbl" : "negative regulation of insulin secretion involved in cellular response to glucose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061181", "lbl" : "regulation of chondrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061182", "lbl" : "negative regulation of chondrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061183", "lbl" : "regulation of dermatome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061184", "lbl" : "positive regulation of dermatome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061185", "lbl" : "negative regulation of dermatome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061189", "lbl" : "positive regulation of sclerotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061190", "lbl" : "regulation of sclerotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061298", "lbl" : "retina vasculature development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061299", "lbl" : "retina vasculature morphogenesis in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the vasculature of the retina is generated and organized.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061303", "lbl" : "cornea development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061304", "lbl" : "retinal blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:BHF", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061307", "lbl" : "cardiac neural crest cell differentiation involved in heart development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart", "PMID:19705442" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061308", "lbl" : "cardiac neural crest cell development involved in heart development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061309", "lbl" : "cardiac neural crest cell development involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061323", "lbl" : "cell proliferation involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061325", "lbl" : "cell proliferation involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061337", "lbl" : "cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061343", "lbl" : "cell adhesion involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart", "PMID:16860783" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061344", "lbl" : "regulation of cell adhesion involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart.", + "xrefs" : [ "GOC:dph", "GOC:mtg_heart", "PMID:16860783" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061351", "lbl" : "neural precursor cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061383", + "lbl" : "trabecula morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061384", + "lbl" : "heart trabecula morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061385", "lbl" : "fibroblast proliferation involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061448", "lbl" : "connective tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of a connective tissue over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061450", "lbl" : "trophoblast cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061453", + "lbl" : "interstitial cell of Cajal differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061458", "lbl" : "reproductive system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061462", "lbl" : "protein localization to lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a lysosome.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061469", + "lbl" : "regulation of type B pancreatic cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061484", "lbl" : "hematopoietic stem cell homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells.", + "xrefs" : [ "GOC:dph", "PMID:21508411" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061512", "lbl" : "protein localization to cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a cilium.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061515", "lbl" : "myeloid cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061519", "lbl" : "macrophage homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.", + "xrefs" : [ "GOC:dph", "PMID:21727904" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061523", "lbl" : "cilium disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the breakdown of a cilium.", + "xrefs" : [ "GOC:cilia", "GOC:dph", "PMID:17604723", "PMID:27350441" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061525", + "lbl" : "hindgut development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061548", "lbl" : "ganglion development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061549", "lbl" : "sympathetic ganglion development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061550", "lbl" : "cranial ganglion development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061551", "lbl" : "trigeminal ganglion development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061552", "lbl" : "ganglion morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of ganglion are generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061553", "lbl" : "ganglion maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061554", "lbl" : "ganglion formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061556", "lbl" : "trigeminal ganglion morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of a trigeminal ganglion is generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061557", "lbl" : "trigeminal ganglion maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061558", "lbl" : "cranial ganglion maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061559", "lbl" : "cranial ganglion morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structure of a cranial ganglion is generated and organized.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061560", "lbl" : "cranial ganglion formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061561", "lbl" : "trigeminal ganglion formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061572", "lbl" : "actin filament bundle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061580", + "lbl" : "colon epithelial cell migration", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061581", "lbl" : "corneal epithelial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "GOC:dph" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0061582", + "lbl" : "intestinal epithelial cell migration", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061626", "lbl" : "pharyngeal arch artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.", + "xrefs" : [ "GOC:BHF", "GOC:dph", "PMID:20122914" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061792", "lbl" : "secretory granule maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "GOC:dph", "PMID:16618809" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061853", "lbl" : "regulation of neuroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuroblast migration.", + "xrefs" : [ "PMID:23149556" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061854", "lbl" : "positive regulation of neuroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuroblast migration.", + "xrefs" : [ "PMID:23149556" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061855", "lbl" : "negative regulation of neuroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration.", + "xrefs" : [ "PMID:23149556" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061900", "lbl" : "glial cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:18723082" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061938", "lbl" : "protein localization to somatodendritic compartment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment.", + "xrefs" : [ "PMID:18341993" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061951", "lbl" : "establishment of protein localization to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location in a plasma membrane.", + "xrefs" : [ "GOC:dph", "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061971", "lbl" : "replacement bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone.", + "xrefs" : [ "PMID:29852585" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061972", "lbl" : "dermal bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which bone which forms superficially in the organism are generated and organized.", + "xrefs" : [ "PMID:12588850", "PMID:15003632" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0061973", "lbl" : "membrane bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which bone which forms deep in the organism are generated and organized.", + "xrefs" : [ "PMID:14579374" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0062012", + "lbl" : "regulation of small molecule metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of a small molecule metabolic process.", + "xrefs" : [ "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0062013", + "lbl" : "positive regulation of small molecule metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process.", + "xrefs" : [ "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0062014", + "lbl" : "negative regulation of small molecule metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process.", + "xrefs" : [ "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062023", "lbl" : "collagen-containing extracellular matrix", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.", + "xrefs" : [ "GOC:BHF", "GOC:rph", "PMID:21123617" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062033", "lbl" : "positive regulation of mitotic sister chromatid segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.", + "xrefs" : [ "PMID:12773390" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062094", "lbl" : "stomach development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ.", + "xrefs" : [ "PMID:11967278" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062149", "lbl" : "detection of stimulus involved in sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal.", + "xrefs" : [ "PMID:19837031" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0062237", "lbl" : "protein localization to postsynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell.", + "xrefs" : [ "PMID:31189538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065002", "lbl" : "intracellular protein transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:isa_complete" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065003", "lbl" : "protein-containing complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065004", "lbl" : "protein-DNA complex assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065007", "lbl" : "biological regulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates a measurable attribute of any biological process, quality or function.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "GOC:mah", "GOC:pr", "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0065009", + "lbl" : "regulation of molecular function", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0065010", "lbl" : "extracellular membrane-bounded organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.", + "xrefs" : [ "GOC:isa_complete" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070013", "lbl" : "intracellular organelle lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organelle lumen that is part of an intracellular organelle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070050", "lbl" : "neuron cellular homeostasis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070062", "lbl" : "extracellular exosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "GOC:vesicles", "PMID:15908444", "PMID:17641064", "PMID:19442504", "PMID:19498381", "PMID:22418571", "PMID:24009894" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070091", "lbl" : "glucagon secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).", + "xrefs" : [ "GOC:BHF", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070092", "lbl" : "regulation of glucagon secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of glucagon.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070093", "lbl" : "negative regulation of glucagon secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070094", "lbl" : "positive regulation of glucagon secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070161", "lbl" : "anchoring junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.", + "xrefs" : [ "ISBN:0815332181" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070192", "lbl" : "chromosome organization involved in meiotic cell cycle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process of chromosome organization that is involved in a meiotic cell cycle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070199", "lbl" : "establishment of protein localization to chromosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location on a chromosome.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070201", "lbl" : "regulation of establishment of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070202", "lbl" : "regulation of establishment of protein localization to chromosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070227", "lbl" : "lymphocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.", + "xrefs" : [ "CL:0000542", "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070228", "lbl" : "regulation of lymphocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070229", "lbl" : "negative regulation of lymphocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070230", "lbl" : "positive regulation of lymphocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070231", "lbl" : "T cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.", + "xrefs" : [ "CL:0000084", "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070232", "lbl" : "regulation of T cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the occurrence or rate of T cell death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070233", "lbl" : "negative regulation of T cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070234", "lbl" : "positive regulation of T cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process.", + "xrefs" : [ "GOC:add", "GOC:mtg_apoptosis", "ISBN:0781765196" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070253", "lbl" : "somatostatin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of somatostatin from secretory granules in the D cells of the pancreas.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070254", + "lbl" : "mucus secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function.", + "xrefs" : [ "GOC:add", "ISBN:068340007X", "ISBN:0721662544" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070255", + "lbl" : "regulation of mucus secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.", + "xrefs" : [ "GOC:add" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070256", + "lbl" : "negative regulation of mucus secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.", + "xrefs" : [ "GOC:add" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070257", + "lbl" : "positive regulation of mucus secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070285", "lbl" : "pigment cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate.", + "xrefs" : [ "GOC:cvs" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070341", "lbl" : "fat cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070344", "lbl" : "regulation of fat cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of fat cell proliferation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070345", "lbl" : "negative regulation of fat cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or decreases the rate or extent of fat cell proliferation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070346", "lbl" : "positive regulation of fat cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of fat cell proliferation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070365", + "lbl" : "hepatocyte differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.", + "xrefs" : [ "CL:0000182", "PMID:7588884" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070366", + "lbl" : "regulation of hepatocyte differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hepatocyte differentiation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070367", + "lbl" : "negative regulation of hepatocyte differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops or decreases the rate or extent of hepatocyte differentiation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070368", + "lbl" : "positive regulation of hepatocyte differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of hepatocyte differentiation.", + "xrefs" : [ "GOC:mah", "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070382", "lbl" : "exocytic vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.", + "xrefs" : [ "GOC:kad", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070482", "lbl" : "response to oxygen levels", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070483", "lbl" : "detection of hypoxia", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0070507", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070507", "lbl" : "regulation of microtubule cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070633", "lbl" : "transepithelial transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a substance from one side of an epithelium to the other.", + "xrefs" : [ "GOC:mah", "GOC:yaf", "ISBN:0716731363" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070634", "lbl" : "transepithelial ammonium transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of ammonium ions from one side of an epithelium to the other.", + "xrefs" : [ "GOC:mah", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070661", "lbl" : "leukocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a leukocyte population by cell division.", + "xrefs" : [ "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070663", "lbl" : "regulation of leukocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of leukocyte proliferation.", + "xrefs" : [ "GOC:add", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070664", "lbl" : "negative regulation of leukocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.", + "xrefs" : [ "GOC:add", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070665", "lbl" : "positive regulation of leukocyte proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.", + "xrefs" : [ "GOC:add", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070727", "lbl" : "cellular macromolecule localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070831", "lbl" : "basement membrane assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070857", + "lbl" : "regulation of bile acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070858", + "lbl" : "negative regulation of bile acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070859", + "lbl" : "positive regulation of bile acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070873", + "lbl" : "regulation of glycogen metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070874", + "lbl" : "negative regulation of glycogen metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0070875", + "lbl" : "positive regulation of glycogen metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070887", "lbl" : "cellular response to chemical stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070925", "lbl" : "organelle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0070977", "lbl" : "bone maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state.", + "xrefs" : [ "GOC:dph", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071168", "lbl" : "protein localization to chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071169", "lbl" : "establishment of protein localization to chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a part of a chromosome that is organized into chromatin.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071242", "lbl" : "cellular response to ammonium ion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:23509267" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071322", "lbl" : "cellular response to carbohydrate stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0071331", + "lbl" : "cellular response to hexose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0071333", + "lbl" : "cellular response to glucose stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071375", "lbl" : "cellular response to peptide hormone stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071377", "lbl" : "cellular response to glucagon stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071383", "lbl" : "cellular response to steroid hormone stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071396", "lbl" : "cellular response to lipid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071417", "lbl" : "cellular response to organonitrogen compound", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071418", "lbl" : "cellular response to amine stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071425", "lbl" : "hematopoietic stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.", + "xrefs" : [ "CL:0000037", "GOC:BHF", "GOC:add", "GOC:mah", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071495", "lbl" : "cellular response to endogenous stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071621", "lbl" : "granulocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a granulocyte in response to an external stimulus.", + "xrefs" : [ "GOC:rph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071622", "lbl" : "regulation of granulocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071623", "lbl" : "negative regulation of granulocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071624", "lbl" : "positive regulation of granulocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071626", "lbl" : "mastication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process of biting and mashing food with the teeth prior to swallowing.", + "xrefs" : [ "GOC:gvg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071670", "lbl" : "smooth muscle cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a smooth muscle cell in response to an external stimulus.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071671", "lbl" : "regulation of smooth muscle cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071672", "lbl" : "negative regulation of smooth muscle cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071673", "lbl" : "positive regulation of smooth muscle cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071674", "lbl" : "mononuclear cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a mononuclear cell within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071675", "lbl" : "regulation of mononuclear cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071676", "lbl" : "negative regulation of mononuclear cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071677", "lbl" : "positive regulation of mononuclear cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071692", "lbl" : "protein localization to extracellular region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071695", "lbl" : "anatomical structure maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071696", "lbl" : "ectodermal placode development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071697", "lbl" : "ectodermal placode morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071705", "lbl" : "nitrogen compound transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071709", "lbl" : "membrane assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071711", "lbl" : "basement membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071763", "lbl" : "nuclear membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071764", "lbl" : "nuclear outer membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071806", "lbl" : "protein transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a protein is transported across a membrane.", + "xrefs" : [ "GOC:mah", "GOC:vw" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071824", "lbl" : "protein-DNA complex organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071826", "lbl" : "protein-RNA complex organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071840", "lbl" : "cellular component organization or biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071869", "lbl" : "response to catecholamine", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071870", "lbl" : "cellular response to catecholamine stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071873", "lbl" : "response to norepinephrine", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + }, + "comments" : [ "Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071874", "lbl" : "cellular response to norepinephrine stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + }, + "comments" : [ "Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071887", "lbl" : "leukocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.", + "xrefs" : [ "CL:0000738", "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071888", "lbl" : "macrophage apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues.", + "xrefs" : [ "CL:0000235", "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis" ] + }, + "comments" : [ "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071897", "lbl" : "DNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The biosynthetic process resulting in the formation of DNA.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071944", "lbl" : "cell periphery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures.", + "xrefs" : [ "GOC:pdt" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071953", "lbl" : "elastic fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "PMID:20236620" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0071971", "lbl" : "extracellular exosome assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm.", + "xrefs" : [ "GOC:mah", "GOC:tfm", "PMID:19442504", "PMID:27462458" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072001", + "lbl" : "renal system development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels.", + "xrefs" : [ "GOC:mtg_kidney_jan10", "GOC:yaf", "PMID:6996269" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072089", "lbl" : "stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.", + "xrefs" : [ "GOC:mtg_kidney_jan10" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072091", "lbl" : "regulation of stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.", + "xrefs" : [ "GOC:mtg_kidney_jan10" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072132", "lbl" : "mesenchyme morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells.", + "xrefs" : [ "GOC:mtg_kidney_jan10" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072175", "lbl" : "epithelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of an epithelial tube.", + "xrefs" : [ "GOC:mtg_kidney_jan10" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072201", "lbl" : "negative regulation of mesenchymal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.", + "xrefs" : [ "GOC:mtg_kidney_jan10" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072329", + "lbl" : "monocarboxylic acid catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072330", + "lbl" : "monocarboxylic acid biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072359", "lbl" : "circulatory system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.", + "xrefs" : [ "GOC:mah", "UBERON:0001009" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072360", "lbl" : "vascular cord development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis.", + "xrefs" : [ "GOC:mah", "PMID:7084422", "ZFA:0005077" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072384", "lbl" : "organelle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072488", "lbl" : "ammonium transmembrane transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+.", + "xrefs" : [ "GOC:mah" ] + }, + "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072537", "lbl" : "fibroblast activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.", + "xrefs" : [ "CL:0000057", "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072560", + "lbl" : "type B pancreatic cell maturation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.", + "xrefs" : [ "CL:0000169", "GOC:BHF" ] + }, + "comments" : [ "These processes continue to 60 DPA in Gossypium spp." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072575", + "lbl" : "epithelial cell proliferation involved in liver morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver.", + "xrefs" : [ "GOC:BHF", "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0072576", + "lbl" : "liver morphogenesis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of the liver are generated and organized.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072577", "lbl" : "endothelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal.", + "xrefs" : [ "CL:0000115", "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072592", "lbl" : "oxygen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving diatomic oxygen (O2).", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072594", "lbl" : "establishment of protein localization to organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072657", "lbl" : "protein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a specific location in a membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072659", "lbl" : "protein localization to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072665", "lbl" : "protein localization to vacuole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained at, a location in a vacuole.", + "xrefs" : [ "GOC:ecd" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072666", "lbl" : "establishment of protein localization to vacuole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location in a vacuole.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072674", "lbl" : "multinuclear osteoclast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.", + "xrefs" : [ "CL:0000779", "GOC:mah", "PMID:12713016" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072676", "lbl" : "lymphocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a lymphocyte within or between different tissues and organs of the body.", + "xrefs" : [ "CL:0000542", "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072678", "lbl" : "T cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a T cell within or between different tissues and organs of the body.", + "xrefs" : [ "CL:0000084", "GOC:BHF", "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072697", "lbl" : "protein localization to cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, the cell cortex.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0072698", "lbl" : "protein localization to microtubule cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0080090", "lbl" : "regulation of primary metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.", + "xrefs" : [ "PMID:19211694" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0080134", "lbl" : "regulation of response to stress", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).", + "xrefs" : [ "GOC:dhl" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0080154", "lbl" : "regulation of fertilization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).", + "xrefs" : [ "GOC:DHL", "PMID:20478994" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0080171", "lbl" : "lytic vacuole organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole.", + "xrefs" : [ "PMID:20729380" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0085029", "lbl" : "extracellular matrix assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of the extracellular matrix.", + "xrefs" : [ "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086001", "lbl" : "cardiac muscle cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An action potential that occurs in a cardiac muscle cell.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086015", "lbl" : "SA node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An action potential that occurs in a sinoatrial node cardiac muscle cell.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086016", "lbl" : "AV node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An action potential that occurs in an atrioventricular node cardiac muscle cell.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086017", "lbl" : "Purkinje myocyte action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An action potential that occurs in a Purkinje myocyte.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086018", "lbl" : "SA node cell to atrial cardiac muscle cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086019", "lbl" : "cell-cell signaling involved in cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086027", "lbl" : "AV node cell to bundle of His cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086029", "lbl" : "Purkinje myocyte to ventricular cardiac muscle cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086065", "lbl" : "cell communication involved in cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086067", "lbl" : "AV node cell to bundle of His cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086068", "lbl" : "Purkinje myocyte to ventricular cardiac muscle cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0086070", "lbl" : "SA node cell to atrial cardiac muscle cell communication", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090025", "lbl" : "regulation of monocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090026", "lbl" : "positive regulation of monocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate, or extent of monocyte chemotaxis.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090027", "lbl" : "negative regulation of monocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090063", "lbl" : "positive regulation of microtubule nucleation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090068", "lbl" : "positive regulation of cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090069", "lbl" : "regulation of ribosome biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090070", "lbl" : "positive regulation of ribosome biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090071", "lbl" : "negative regulation of ribosome biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090087", "lbl" : "regulation of peptide transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090091", "lbl" : "positive regulation of extracellular matrix disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090130", "lbl" : "tissue migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the population of cells that make up a tissue undergo directed movement.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090132", "lbl" : "epithelium migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the population of cells that make up an epithelium undergo directed movement.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090138", "lbl" : "regulation of actin cytoskeleton organization by cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090150", "lbl" : "establishment of protein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location in a membrane.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090162", "lbl" : "establishment of epithelial cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The specification and formation of anisotropic intracellular organization of an epithelial cell.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090166", "lbl" : "Golgi disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090168", "lbl" : "Golgi reassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090170", "lbl" : "regulation of Golgi inheritance", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090171", "lbl" : "chondrocyte morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090174", "lbl" : "organelle membrane fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The joining of two lipid bilayers to form a single organelle membrane.", + "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090257", "lbl" : "regulation of muscle system process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090273", "lbl" : "regulation of somatostatin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090274", "lbl" : "positive regulation of somatostatin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090275", "lbl" : "negative regulation of somatostatin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090276", "lbl" : "regulation of peptide hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090277", "lbl" : "positive regulation of peptide hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090278", "lbl" : "negative regulation of peptide hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090289", "lbl" : "regulation of osteoclast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090290", "lbl" : "positive regulation of osteoclast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090291", "lbl" : "negative regulation of osteoclast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090299", "lbl" : "regulation of neural crest formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090300", "lbl" : "positive regulation of neural crest formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090301", "lbl" : "negative regulation of neural crest formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090316", "lbl" : "positive regulation of intracellular protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090317", "lbl" : "negative regulation of intracellular protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.", + "xrefs" : [ "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0090325", + "lbl" : "regulation of locomotion involved in locomotory behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.", + "xrefs" : [ "GOC:dph", "GOC:kmv", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0090326", + "lbl" : "positive regulation of locomotion involved in locomotory behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.", + "xrefs" : [ "GOC:dph", "GOC:kmv", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0090327", + "lbl" : "negative regulation of locomotion involved in locomotory behavior", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.", + "xrefs" : [ "GOC:dph", "GOC:kmv", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0090425", + "lbl" : "acinar cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090435", "lbl" : "protein localization to nuclear envelope", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.", + "xrefs" : [ "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090493", "lbl" : "catecholamine uptake", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of catecholamine into a cell.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090497", "lbl" : "mesenchymal cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090596", "lbl" : "sensory organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.", + "xrefs" : [ "GOC:kmv", "ISBN:978-0199210893" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090685", "lbl" : "RNA localization to nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus.", + "xrefs" : [ "GOC:mah", "PMID:26305931" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0090741", "lbl" : "pigment granule membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any membrane that is part of a pigment granule.", + "xrefs" : [ "PMID:11294610" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097014", "lbl" : "ciliary plasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.", + "xrefs" : [ "GOC:BHF", "GOC:cilia", "GOC:dos", "PMID:17895364" ] + }, + "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term \"ciliary plasm\" is not linked to \"cytoplasm\"." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097026", "lbl" : "dendritic cell dendrite assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.", + "xrefs" : [ "CL:0000451", "GOC:BHF", "PMID:12200351" ] + }, + "comments" : [ "Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097028", "lbl" : "dendritic cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.", + "xrefs" : [ "CL:0000451", "GOC:pr" ] + }, + "comments" : [ "Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097048", "lbl" : "dendritic cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.", + "xrefs" : [ "CL:0000451", "GOC:BHF", "GOC:mtg_apoptosis", "PMID:15059845" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097049", "lbl" : "motor neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.", + "xrefs" : [ "CL:0000100", "GOC:BHF", "GOC:mtg_apoptosis", "PMID:14523086" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097050", + "lbl" : "type B pancreatic cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin.", + "xrefs" : [ "CL:0000169", "GOC:BHF", "GOC:mtg_apoptosis", "PMID:16087305" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097060", "lbl" : "synaptic membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.", + "xrefs" : [ "GOC:BHF", "PMID:20410104" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097084", "lbl" : "vascular associated smooth muscle cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097152", "lbl" : "mesenchymal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.", + "xrefs" : [ "CL:0000134", "GOC:mtg_apoptosis", "GOC:yaf", "PMID:18231833" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097164", "lbl" : "ammonium ion metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving the ammonium ion.", + "xrefs" : [ "GOC:dhl", "GOC:tb", "PMID:14671018" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097190", "lbl" : "apoptotic signaling pathway", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.", + "xrefs" : [ "GOC:mtg_apoptosis" ] + }, + "comments" : [ "This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097194", "lbl" : "execution phase of apoptosis", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_0097212", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.", + "xrefs" : [ "GOC:mtg_apoptosis", "PMID:21760595" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097212", "lbl" : "lysosomal membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.", + "xrefs" : [ "GOC:yaf", "PMID:20544854" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097237", + "lbl" : "cellular response to toxic substance", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.", + "xrefs" : [ "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097254", + "lbl" : "renal tubular secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.", + "xrefs" : [ "GOC:rph", "PMID:25287933", "Wikipedia:Renal_secretion#Secretion" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097272", + "lbl" : "ammonium homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any biological process involved in the maintenance of an internal steady state of ammonium.", + "xrefs" : [ "GOC:yaf", "PMID:12695560" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097275", + "lbl" : "intracellular ammonium homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell.", + "xrefs" : [ "GOC:yaf", "PMID:12695560" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0097284", + "lbl" : "hepatocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a hepatocyte, the main structural component of the liver.", + "xrefs" : [ "CL:0000182", "GOC:jc", "GOC:mtg_apoptosis", "PMID:15856020" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097355", "lbl" : "protein localization to heterochromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097386", "lbl" : "glial cell projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A prolongation or process extending from a glial cell.", + "xrefs" : [ "GOC:mc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097402", "lbl" : "neuroblast migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.", + "xrefs" : [ "CL:0000031", "GOC:jc", "PMID:15543145" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097427", "lbl" : "microtubule bundle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arrangement of closely apposed microtubules running parallel to each other.", + "xrefs" : [ "NIF_Subcellular:sao1872343973" ] + }, + "xrefs" : [ { + "val" : "NIF_Subcellular:sao1872343973" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097435", "lbl" : "supramolecular fiber organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.", + "xrefs" : [ "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097473", "lbl" : "retinal rod cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina.", + "xrefs" : [ "CL:0000604", "GOC:jc", "PMID:17202487" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097474", "lbl" : "retinal cone cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina.", + "xrefs" : [ "CL:0000573", "GOC:jc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097475", "lbl" : "motor neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.", + "xrefs" : [ "CL:0000100", "GOC:yaf", "PMID:20711475" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097476", "lbl" : "spinal cord motor neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.", + "xrefs" : [ "CL:0011001", "GOC:yaf", "PMID:20711475" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097511", "lbl" : "dendritic cell dendrite", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.", + "xrefs" : [ "CL:0000451", "GOC:BHF", "GOC:cjm", "PMID:12200351" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097512", "lbl" : "cardiac myofibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac myofibril is a myofibril specific to cardiac muscle cells.", + "xrefs" : [ "GOC:cjm", "GOC:devbiol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097529", "lbl" : "myeloid leukocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a myeloid leukocyte within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:cvs", "PMID:22342843", "PMID:24157461" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097530", "lbl" : "granulocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a granulocyte within or between different tissues and organs of the body.", + "xrefs" : [ "GOC:cvs", "PMID:24163421", "PMID:24193336" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097534", "lbl" : "lymphoid lineage cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage.", + "xrefs" : [ "GOC:pr", "PMID:22342843" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097576", "lbl" : "vacuole fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole.", + "xrefs" : [ "GOC:pr", "GOC:vw", "Wikipedia:Vacuole" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097708", "lbl" : "intracellular vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vesicle that is part of the intracellular region.", + "xrefs" : [ "GOC:vesicles" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097711", "lbl" : "ciliary basal body-plasma membrane docking", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.", + "xrefs" : [ "GOC:cilia", "PMID:13978319", "PMID:23348840", "PMID:23530209", "PMID:25686250", "PMID:26981235" ] + }, + "comments" : [ "Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097712", "lbl" : "vesicle targeting, trans-Golgi to periciliary membrane compartment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces.", + "xrefs" : [ "GOC:cilia", "PMID:20106869", "PMID:23351793", "PMID:24814148", "PMID:26485645" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0097734", "lbl" : "extracellular exosome biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "PMID:19442504", "PMID:25392495" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098523", "lbl" : "neuromuscular junction of myotube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuromuscular junction in which the target muscle cell is a myotube.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098528", "lbl" : "skeletal muscle fiber differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098588", "lbl" : "bounding membrane of organelle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer that forms the outer-most layer of an organelle.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098590", "lbl" : "plasma membrane region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membrane that is a (regional) part of the plasma membrane.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098609", "lbl" : "cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The attachment of one cell to another cell via adhesion molecules.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098635", "lbl" : "protein complex involved in cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098636", "lbl" : "protein complex involved in cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098642", "lbl" : "network-forming collagen trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collagen trimer that forms networks.", + "xrefs" : [ "PMID:21421911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098643", "lbl" : "banded collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands).", + "xrefs" : [ "GOC:dos", "PMID:21421911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098644", "lbl" : "complex of collagen trimers", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A complex of collagen trimers such as a fibril or collagen network.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098645", "lbl" : "collagen network", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A supramolecular complex that consists of collagen triple helices associated to form a network.", + "xrefs" : [ "GOC:dos", "PMID:21421911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098651", "lbl" : "basement membrane collagen trimer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collagen timer that is part of a basement membrane.", + "xrefs" : [ "GOC:dos", "PMID:21421911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098657", "lbl" : "import into cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098722", "lbl" : "asymmetric stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity.", + "xrefs" : [ "GOC:dos", "PMID:18513950" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098723", "lbl" : "skeletal muscle myofibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myofibril of a skeletal muscle fiber.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098728", "lbl" : "germline stem cell asymmetric division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098751", "lbl" : "bone cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0098754", + "lbl" : "detoxification", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098773", "lbl" : "skin epidermis development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098793", "lbl" : "presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of a synapse that is part of the presynaptic cell.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098794", "lbl" : "postsynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of a synapse that is part of the post-synaptic cell.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098796", "lbl" : "membrane protein complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any protein complex that is part of a membrane.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098797", "lbl" : "plasma membrane protein complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any protein complex that is part of the plasma membrane.", + "xrefs" : [ "GOC:dos" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0098801", + "lbl" : "regulation of renal system process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098813", "lbl" : "nuclear chromosome segregation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098840", "lbl" : "protein transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein along a microtubule, mediated by motor proteins.", + "xrefs" : [ "PMID:25987607" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098852", "lbl" : "lytic vacuole membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098858", "lbl" : "actin-based cell projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cell projection supported by an assembly of actin filaments, and which lacks microtubules.", + "xrefs" : [ "PMID:15661519" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098867", "lbl" : "intramembranous bone growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone.", + "xrefs" : [ "PMID:26399686" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098868", "lbl" : "bone growth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The increase in size or mass of a bone that contributes to the shaping of that bone.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098871", "lbl" : "postsynaptic actin cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The actin cytoskeleton that is part of a postsynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098876", "lbl" : "vesicle-mediated transport to the plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098883", "lbl" : "synapse pruning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.", + "xrefs" : [ "GOC:dos", "PMID:12062020", "PMID:18083105", "PMID:22632716", "PMID:29844190" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098900", "lbl" : "regulation of action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:dos", "GOC:dph", "GOC:go_curators", "GOC:tb", "ISBN:978-0-07-139011-8" ] + }, + "comments" : [ "The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098901", "lbl" : "regulation of cardiac muscle cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:dos", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098904", "lbl" : "regulation of AV node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098906", "lbl" : "regulation of Purkinje myocyte action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098907", "lbl" : "regulation of SA node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098908", "lbl" : "regulation of neuronal action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.", + "xrefs" : [ "GOC:dph", "GOC:isa_complete", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098916", "lbl" : "anterograde trans-synaptic signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling from pre to post-synapse, across the synaptic cleft.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098917", "lbl" : "retrograde trans-synaptic signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling from post to pre-synapse, across the synaptic cleft.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098920", "lbl" : "retrograde trans-synaptic signaling by lipid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098926", "lbl" : "postsynaptic signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Signal transduction in which the initial step occurs in a postsynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098928", "lbl" : "presynaptic signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Signal transduction in which the initial step occurs in a presynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098974", "lbl" : "postsynaptic actin cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098975", "lbl" : "postsynapse of neuromuscular junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma.", + "xrefs" : [ "GOC:dos", "Wikipedia:Neuromuscular_junction&oldid=723623502" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0098992", "lbl" : "neuronal dense core vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals.", + "xrefs" : [ "GOC:dos", "ISBN:978-0-07-181001-2", "Wikipedia:Neuropeptide&oldid=713905176" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099003", "lbl" : "vesicle-mediated transport in synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vesicle-mediated transport that occurs in a synapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099012", "lbl" : "neuronal dense core vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding a neuronal dense core vesicle.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099014", "lbl" : "neuronal dense core vesicle organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099054", "lbl" : "presynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a presynapse.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "GOC:dos", "PMID:24449494" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099068", "lbl" : "postsynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a postsynapse.", + "xrefs" : [ "GOC:bf", "GOC:dos", "GOCL:PARL" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099080", "lbl" : "supramolecular complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099081", "lbl" : "supramolecular polymer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A polymeric supramolecular structure.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099082", "lbl" : "retrograde trans-synaptic signaling by neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "GOC:dos", "PMID:19448629" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099083", "lbl" : "retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide.", + "xrefs" : [ "GOC:PARL", "GOC:bf", "GOC:dos", "PMID:19448629" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099098", "lbl" : "microtubule polymerization based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The movement of a cellular component as a result of microtubule polymerization.", + "xrefs" : [ "GOC:cjm", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099111", "lbl" : "microtubule-based transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.", + "xrefs" : [ "GOC:cjm", "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099112", "lbl" : "microtubule polymerization based protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The transport of a protein driven by polymerization of a microtubule to which it is attached.", + "xrefs" : [ "GOC:dos", "GOC:vw", "PMID:11018050" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099118", "lbl" : "microtubule-based protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A microtubule-based process that results in the transport of proteins.", + "xrefs" : [ "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099140", "lbl" : "presynaptic actin cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099143", "lbl" : "presynaptic actin cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The actin cytoskeleton that is part of a presynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099156", "lbl" : "cell-cell signaling via exosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling in which the ligand is carried between cells by an exosome.", + "xrefs" : [ "GOC:dos", "PMID:19837038" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099157", "lbl" : "trans-synaptic signaling via exosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Transynaptic signaling in which the ligand is carried across the synapse by an exosome.", + "xrefs" : [ "GOC:dos", "PMID:19837038" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099170", "lbl" : "postsynaptic modulation of chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099171", "lbl" : "presynaptic modulation of chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099172", "lbl" : "presynapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099173", "lbl" : "postsynapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099174", "lbl" : "regulation of presynapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the physical form of a presynapse.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099175", "lbl" : "regulation of postsynapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the physical form of a postsynapse.", + "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099177", "lbl" : "regulation of trans-synaptic signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of trans-synaptic signaling.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099187", "lbl" : "presynaptic cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099188", "lbl" : "postsynaptic cytoskeleton organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099500", "lbl" : "vesicle fusion to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "ISBN:0071120009", "PMID:18618940" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099501", "lbl" : "exocytic vesicle membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lipid bilayer surrounding an exocytic vesicle.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099503", "lbl" : "secretory vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099512", "lbl" : "supramolecular fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099513", "lbl" : "polymeric cytoskeletal fiber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099515", "lbl" : "actin filament-based transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The transport of organelles or other particles from one location in the cell to another along actin filaments.", + "xrefs" : [ "GOC:dos", "GOC:dph", "GOC:mah", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099518", "lbl" : "vesicle cytoskeletal trafficking", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins.", + "xrefs" : [ "GOC:ecd", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099531", "lbl" : "presynaptic process involved in chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099536", "lbl" : "synaptic signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling to, from or within a synapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099537", "lbl" : "trans-synaptic signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling in either direction across the synaptic cleft.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099538", "lbl" : "synaptic signaling via neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling to or from a synapse, mediated by a peptide.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099540", "lbl" : "trans-synaptic signaling by neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099541", "lbl" : "trans-synaptic signaling by lipid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid.", + "xrefs" : [ "GOC:dos" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0099546", + "lbl" : "protein catabolic process, modulating synaptic transmission", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.", + "xrefs" : [ "GOC:dos", "PMID:23083742" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099547", "lbl" : "regulation of translation at synapse, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating translation occurring at the synapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099550", "lbl" : "trans-synaptic signaling, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099551", "lbl" : "trans-synaptic signaling by neuropeptide, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099552", "lbl" : "trans-synaptic signaling by lipid, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse.", + "xrefs" : [ "GOC:dos", "PMID:21531987" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099568", "lbl" : "cytoplasmic region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099569", "lbl" : "presynaptic cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the cytoskeleton contained within the presynapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099571", "lbl" : "postsynaptic cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of the cytoskeleton contained within the postsynapse.", + "xrefs" : [ "GOC:dos", "PMID:19889835" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0099574", + "lbl" : "regulation of protein catabolic process at synapse, modulating synaptic transmission", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating protein degradation at the synapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0099575", + "lbl" : "regulation of protein catabolic process at presynapse, modulating synaptic transmission", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0099576", + "lbl" : "regulation of protein catabolic process at postsynapse, modulating synaptic transmission", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099577", "lbl" : "regulation of translation at presynapse, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099578", "lbl" : "regulation of translation at postsynapse, modulating synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.", + "xrefs" : [ "GOC:dos" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099632", "lbl" : "protein transport within plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which protein is transported from one region of the plasma membrane to another.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099640", "lbl" : "axo-dendritic protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of proteins along microtubules in neuron projections.", + "xrefs" : [ "ISBN:0815316194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099643", "lbl" : "signal release from synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any signal release from a synapse.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0099738", "lbl" : "cell cortex region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The complete extent of cell cortex that underlies some some region of the plasma membrane.", + "xrefs" : [ "GOC:dos" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0100001", "lbl" : "regulation of skeletal muscle contraction by action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any action potential process that regulates skeletal muscle contraction.", + "xrefs" : [ "GOC:cjm", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0101023", "lbl" : "vascular endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:nc", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0101024", "lbl" : "mitotic nuclear membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis.", + "xrefs" : [ "GOC:vw", "PMID:15147872" ] + }, + "comments" : [ "This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0101025", "lbl" : "nuclear membrane biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a nuclear membrane is synthesized, aggregates, and bonds together.", + "xrefs" : [ "GOC:vw" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0106027", "lbl" : "neuron projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:11585923" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0106214", "lbl" : "regulation of vesicle fusion with Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus.", + "xrefs" : [ "GOC:se", "PMID:26195667" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0106215", "lbl" : "negative regulation of vesicle fusion with Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus.", + "xrefs" : [ "GOC:se", "PMID:26195667" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0106216", "lbl" : "positive regulation of vesicle fusion with Golgi apparatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus.", + "xrefs" : [ "GOC:se", "PMID:26195667" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110011", "lbl" : "regulation of basement membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane.", + "xrefs" : [ "GOC:ha", "PMID:27404358" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110020", "lbl" : "regulation of actomyosin structure organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin.", + "xrefs" : [ "GOC:lf", "PMID:22790195" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110021", "lbl" : "cardiac muscle myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:26512644" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110022", "lbl" : "regulation of cardiac muscle myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:26512644" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110023", "lbl" : "negative regulation of cardiac muscle myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:26512644" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110024", "lbl" : "positive regulation of cardiac muscle myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:26512644" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110053", "lbl" : "regulation of actin filament organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of actin filament organization.", + "xrefs" : [ "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110057", "lbl" : "regulation of blood vessel endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:23072816" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110058", "lbl" : "positive regulation of blood vessel endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:23072816" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110059", "lbl" : "negative regulation of blood vessel endothelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:23072816" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110077", "lbl" : "vesicle-mediated intercellular transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane.", + "xrefs" : [ "GOC:sp", "PMID:29328915", "PMID:29328916" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110110", "lbl" : "positive regulation of animal organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis.", + "xrefs" : [ "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110111", "lbl" : "negative regulation of animal organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis.", + "xrefs" : [ "GOC:kmv" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0110112", + "lbl" : "regulation of lipid transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate, or extent of lipid transporter activity.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:27365390" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0110113", + "lbl" : "positive regulation of lipid transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that increases the frequency, rate, or extent of lipid transporter activity.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:27365390" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0110114", + "lbl" : "negative regulation of lipid transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that decreases the frequency, rate, or extent of lipid transporter activity.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:27365390" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110116", "lbl" : "regulation of compound eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation.", + "xrefs" : [ "GOC:ha", "PMID:16377567" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110117", "lbl" : "positive regulation of compound eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation.", + "xrefs" : [ "GOC:ha", "PMID:16377567" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110118", "lbl" : "negative regulation of compound eye photoreceptor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation.", + "xrefs" : [ "GOC:ha", "PMID:16377567" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110122", "lbl" : "myotube cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse.", + "xrefs" : [ "GOC:ha", "PMID:29122742" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110123", "lbl" : "regulation of myotube cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myotube cell migration.", + "xrefs" : [ "GOC:ha", "PMID:29122742" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110124", "lbl" : "positive regulation of myotube cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration.", + "xrefs" : [ "GOC:ha", "PMID:29122742" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110125", "lbl" : "negative regulation of myotube cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration.", + "xrefs" : [ "GOC:ha", "PMID:29122742" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0110165", "lbl" : "cellular anatomical entity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.", + "xrefs" : [ "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120025", "lbl" : "plasma membrane bounded cell projection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120031", "lbl" : "plasma membrane bounded cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120032", "lbl" : "regulation of plasma membrane bounded cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120033", "lbl" : "negative regulation of plasma membrane bounded cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120034", "lbl" : "positive regulation of plasma membrane bounded cell projection assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120035", "lbl" : "regulation of plasma membrane bounded cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120036", "lbl" : "plasma membrane bounded cell projection organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120039", "lbl" : "plasma membrane bounded cell projection morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120111", "lbl" : "neuron projection cytoplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection.", + "xrefs" : [ "GOC:ha" ] + } + } }, { - "id" : "http://purl.obolibrary.org/obo/GO_0120186", - "lbl" : "negative regulation of protein localization to chromatin", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/GO_0120158", + "lbl" : "positive regulation of collagen catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.", + "xrefs" : [ "GOC:dph", "GOC:tb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0120178", + "lbl" : "steroid hormone biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.", + "xrefs" : [ "GOC:krc", "GOC:nln" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0120186", + "lbl" : "negative regulation of protein localization to chromatin", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin.", + "xrefs" : [ "PMID:20889714", "PMID:29899453" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120187", "lbl" : "positive regulation of protein localization to chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin.", + "xrefs" : [ "PMID:20889714", "PMID:29899453" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0120188", + "lbl" : "regulation of bile acid secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:22767443" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0120189", + "lbl" : "positive regulation of bile acid secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:22767443" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0120190", + "lbl" : "negative regulation of bile acid secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:rph", "PMID:22767443" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120222", "lbl" : "regulation of blastocyst development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of blastocyst development.", + "xrefs" : [ "GOC:krc", "PMID:29593216" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120229", "lbl" : "protein localization to motile cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a motile cilium.", + "xrefs" : [ "GOC:krc", "PMID:27486780" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120305", "lbl" : "regulation of pigmentation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism.", + "xrefs" : [ "GOC:krc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0120331", "lbl" : "endothelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process pertaining to the initial formation of an endothelial tube.", + "xrefs" : [ "GOC:sl", "PMID:23239824" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140013", "lbl" : "meiotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the two nuclear divisions that occur as part of the meiotic cell cycle.", + "xrefs" : [ "PMID:9334324" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140014", "lbl" : "mitotic nuclear division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.", + "xrefs" : [ "ISBN:0198547684" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140029", "lbl" : "exocytic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cellular processes that contribute to exocytosis.", + "xrefs" : [ "Wikipedia:Exocytosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140039", "lbl" : "cell-cell adhesion in response to extracellular stimulus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus.", + "xrefs" : [ "PMID:14996911" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140056", "lbl" : "organelle localization by membrane tethering", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other.", + "xrefs" : [ "PMID:27875684" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140075", "lbl" : "regulation of lipoprotein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that controls lipoprotein transport.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:RPH", "PMID:26501192" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140076", "lbl" : "negative regulation of lipoprotein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:RPH", "PMID:26501192" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140077", "lbl" : "positive regulation of lipoprotein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the rate or extent of lipoprotein transport.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:RPH", "PMID:26501192" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140096", + "lbl" : "catalytic activity, acting on a protein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalytic activity that acts to modify a protein.", + "xrefs" : [ "GOC:molecular_function_refactoring", "GOC:pdt" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140097", + "lbl" : "catalytic activity, acting on DNA", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalytic activity that acts to modify DNA.", + "xrefs" : [ "GOC:molecular_function_refactoring", "GOC:pdt" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140098", + "lbl" : "catalytic activity, acting on RNA", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalytic activity that acts to modify RNA, driven by ATP hydrolysis.", + "xrefs" : [ "GOC:molecular_function_refactoring", "GOC:pdt" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140103", + "lbl" : "catalytic activity, acting on a glycoprotein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein.", + "xrefs" : [ "GOC:molecular_function_refactoring", "GOC:pdt" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140112", "lbl" : "extracellular vesicle biogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.", + "xrefs" : [ "PMID:28736435" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140131", "lbl" : "positive regulation of lymphocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis.", + "xrefs" : [ "PMID:19255442" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140236", "lbl" : "translation at presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Translation that occurs at the presynapse.", + "xrefs" : [ "PMID:27321671" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140237", "lbl" : "translation at presynapse, modulating chemical synaptic transmission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.", + "xrefs" : [ "PMID:27321671" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140238", "lbl" : "presynaptic endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.", + "xrefs" : [ "PMID:24719103" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140239", "lbl" : "postsynaptic endocytosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.", + "xrefs" : [ "PMID:12839988" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140241", "lbl" : "translation at synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Translation that occurs at the synapse.", + "xrefs" : [ "PMID:23083742" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140242", "lbl" : "translation at postsynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Translation that occurs at the postsynapse.", + "xrefs" : [ "PMID:20427644" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140243", "lbl" : "regulation of translation at synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that regulates translation occurring at the synapse.", + "xrefs" : [ "PMID:20427644" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140244", "lbl" : "regulation of translation at presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that regulates translation occurring at the presynapse.", + "xrefs" : [ "PMID:20427644" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140245", "lbl" : "regulation of translation at postsynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that regulates translation occurring at the postsynapse.", + "xrefs" : [ "PMID:20427644" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140246", + "lbl" : "protein catabolic process at synapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse.", + "xrefs" : [ "PMID:17062563" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140247", + "lbl" : "protein catabolic process at presynapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse.", + "xrefs" : [ "PMID:27764673" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140249", + "lbl" : "protein catabolic process at postsynapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse.", + "xrefs" : [ "PMID:17062563" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140250", + "lbl" : "regulation protein catabolic process at synapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse.", + "xrefs" : [ "PMID:23083742" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140251", + "lbl" : "regulation protein catabolic process at presynapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.", + "xrefs" : [ "PMID:27764673" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140252", + "lbl" : "regulation protein catabolic process at postsynapse", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.", + "xrefs" : [ "PMID:17062563" ] + }, + "comments" : [ "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140253", "lbl" : "cell-cell fusion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.", + "xrefs" : [ "Wikipedia:Cell_fusion" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140318", + "lbl" : "protein transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Directly binding to a specific protein and delivering it to a specific cellular location.", + "xrefs" : [ "PMID:18706423" ] + }, + "comments" : [ "Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation." ], + "xrefs" : [ { + "val" : "Reactome:R-HSA-2248891" + }, { + "val" : "Reactome:R-HSA-9662747" + }, { + "val" : "Reactome:R-HSA-9662818" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140352", "lbl" : "export from cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140353", "lbl" : "lipid export from cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a lipid from a cell, into the extracellular region.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140354", "lbl" : "lipid import into cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140513", "lbl" : "nuclear protein-containing complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.", + "xrefs" : [ "GOC:pg" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140572", "lbl" : "vacuole fission", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The division of a vacuole within a cell to form two or more separate vacuoles.", + "xrefs" : [ "PMID:19643199" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0140694", "lbl" : "non-membrane-bounded organelle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.", + "xrefs" : [ "PMID:28225081" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140734", + "lbl" : "ammonium excretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The elimination of ammonium ions from an excretory cell.", + "xrefs" : [ "PMID:25740900" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0140962", + "lbl" : "multicellular organismal-level chemical homeostasis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150031", "lbl" : "regulation of protein localization to lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to lysosome.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:24305806" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150032", "lbl" : "positive regulation of protein localization to lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to lysosome.", + "xrefs" : [ "GOC:aruk", "GOC:bc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150033", "lbl" : "negative regulation of protein localization to lysosome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:24305806" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150052", "lbl" : "regulation of postsynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:16394100", "PMID:16672654", "PMID:28185854" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150063", "lbl" : "visual system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "GOC:krc", "PMID:15004427", "PMID:20647017", "PMID:22632727" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150076", "lbl" : "neuroinflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:10981966", "PMID:11099416", "PMID:18164423" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150077", "lbl" : "regulation of neuroinflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuroinflammatory response.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:10981966", "PMID:11099416", "PMID:18164423" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150078", "lbl" : "positive regulation of neuroinflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response.", + "xrefs" : [ "GOC:aruk", "GOC:bc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150079", "lbl" : "negative regulation of neuroinflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:11099416", "PMID:18164423" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150098", "lbl" : "glial cell-neuron signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:14980203", "PMID:16144764", "PMID:16547515", "PMID:18685038", "PMID:27788368", "PMID:9459440" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150099", "lbl" : "neuron-glial cell signaling", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:10195197", "PMID:10196584", "PMID:10377338", "PMID:10493741", "PMID:11356870", "PMID:11399439", "PMID:15252819", "PMID:27788368" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150102", "lbl" : "negative regulation of monocyte activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation.", + "xrefs" : [ "GOC:aruk", "PMID:15597323" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150105", "lbl" : "protein localization to cell-cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:26706435" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150106", "lbl" : "regulation of protein localization to cell-cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:26706435" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150107", "lbl" : "positive regulation of protein localization to cell-cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction.", + "xrefs" : [ "GOC:aruk", "GOC:bc", "PMID:26706435" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150111", "lbl" : "regulation of transepithelial transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of transepithelial transport.", + "xrefs" : [ "GOC:aruk", "PMID:27593915" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150119", "lbl" : "negative regulation of protein localization to cell-cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction.", + "xrefs" : [ "GOC:aruk", "GOC:bc" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150146", "lbl" : "cell junction disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a cell junction into its constituent components.", + "xrefs" : [ "GOC:aruk", "PMID:25490267" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0150147", "lbl" : "cell-cell junction disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a cell-cell junction into its constituent components.", + "xrefs" : [ "GOC:aruk", "PMID:25490267" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0160038", "lbl" : "somatic sensory system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain.", + "xrefs" : [ "PMID:25832476", "PMID:31399790" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0160093", "lbl" : "chordate pharynx development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure.", + "xrefs" : [ "PMID:23020903" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0170055", + "lbl" : "lipid transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a lipid from one side of a membrane to the other.", + "xrefs" : [ "GOC:curators" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900015", "lbl" : "regulation of cytokine production involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900016", "lbl" : "negative regulation of cytokine production involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900017", "lbl" : "positive regulation of cytokine production involved in inflammatory response", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1900076", + "lbl" : "regulation of cellular response to insulin stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1900077", + "lbl" : "negative regulation of cellular response to insulin stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1900078", + "lbl" : "positive regulation of cellular response to insulin stimulus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900115", "lbl" : "extracellular regulation of signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any regulation of signal transduction that takes place in the extracellular region.", + "xrefs" : [ "GOC:TermGenie", "GOC:signaling" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900116", "lbl" : "extracellular negative regulation of signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any negative regulation of signal transduction that takes place in extracellular region.", + "xrefs" : [ "GOC:TermGenie", "GOC:signaling" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900117", "lbl" : "regulation of execution phase of apoptosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of execution phase of apoptosis.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900118", "lbl" : "negative regulation of execution phase of apoptosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900119", "lbl" : "positive regulation of execution phase of apoptosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900125", "lbl" : "regulation of hyaluronan biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900126", "lbl" : "negative regulation of hyaluronan biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900127", "lbl" : "positive regulation of hyaluronan biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900150", "lbl" : "regulation of defense response to fungus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of defense response to fungus.", + "xrefs" : [ "GOC:TermGenie", "GOC:dhl", "PMID:22242006" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900180", "lbl" : "regulation of protein localization to nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to nucleus.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900181", "lbl" : "negative regulation of protein localization to nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900182", "lbl" : "positive regulation of protein localization to nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900193", "lbl" : "regulation of oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900194", "lbl" : "negative regulation of oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900195", "lbl" : "positive regulation of oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900366", "lbl" : "negative regulation of defense response to insect", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect.", + "xrefs" : [ "GOC:TermGenie", "PMID:22474183" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900367", "lbl" : "positive regulation of defense response to insect", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of defense response to insect.", + "xrefs" : [ "GOC:TermGenie", "PMID:22474183" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900424", "lbl" : "regulation of defense response to bacterium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of defense response to bacterium.", + "xrefs" : [ "GOC:TermGenie", "PMID:22346749" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900425", "lbl" : "negative regulation of defense response to bacterium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.", + "xrefs" : [ "GOC:TermGenie", "PMID:22346749" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1900426", "lbl" : "positive regulation of defense response to bacterium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of defense response to bacterium.", + "xrefs" : [ "GOC:TermGenie", "PMID:22346749" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901142", + "lbl" : "insulin metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving insulin.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901143", + "lbl" : "insulin catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of insulin.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901148", "lbl" : "gene expression involved in extracellular matrix organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form.", + "xrefs" : [ "GOC:TermGenie", "GOC:pg", "PMID:18668558" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901160", "lbl" : "primary amino compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving primary amino compound.", + "xrefs" : [ "GOC:TermGenie" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901161", + "lbl" : "primary amino compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of primary amino compound.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901162", "lbl" : "primary amino compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of primary amino compound.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901163", "lbl" : "regulation of trophoblast cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of trophoblast cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901164", "lbl" : "negative regulation of trophoblast cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901165", "lbl" : "positive regulation of trophoblast cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901166", "lbl" : "neural crest cell migration involved in autonomic nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neural crest cell migration that is involved in autonomic nervous system development.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901190", "lbl" : "regulation of formation of translation initiation ternary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901191", "lbl" : "negative regulation of formation of translation initiation ternary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901192", "lbl" : "positive regulation of formation of translation initiation ternary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901201", "lbl" : "regulation of extracellular matrix assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of extracellular matrix assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901202", "lbl" : "negative regulation of extracellular matrix assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901203", "lbl" : "positive regulation of extracellular matrix assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901210", "lbl" : "regulation of cardiac chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac chamber formation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901211", "lbl" : "negative regulation of cardiac chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901212", "lbl" : "positive regulation of cardiac chamber formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901219", "lbl" : "regulation of cardiac chamber morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901220", "lbl" : "negative regulation of cardiac chamber morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901221", "lbl" : "positive regulation of cardiac chamber morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901246", "lbl" : "regulation of lung ciliated cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901247", "lbl" : "negative regulation of lung ciliated cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901248", "lbl" : "positive regulation of lung ciliated cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901342", "lbl" : "regulation of vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vasculature development.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901343", "lbl" : "negative regulation of vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901509", "lbl" : "regulation of endothelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901532", "lbl" : "regulation of hematopoietic progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901533", "lbl" : "negative regulation of hematopoietic progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901534", "lbl" : "positive regulation of hematopoietic progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901550", "lbl" : "regulation of endothelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial cell development.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr", "PMID:19470579" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901551", "lbl" : "negative regulation of endothelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr", "PMID:19470579" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901552", "lbl" : "positive regulation of endothelial cell development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial cell development.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr", "PMID:19470579" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901564", "lbl" : "organonitrogen compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving organonitrogen compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901565", + "lbl" : "organonitrogen compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of organonitrogen compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901566", "lbl" : "organonitrogen compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of organonitrogen compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901608", "lbl" : "regulation of vesicle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901609", "lbl" : "negative regulation of vesicle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901610", "lbl" : "positive regulation of vesicle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901615", "lbl" : "organic hydroxy compound metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving organic hydroxy compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901616", + "lbl" : "organic hydroxy compound catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901617", "lbl" : "organic hydroxy compound biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of organic hydroxy compound.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901618", + "lbl" : "organic hydroxy compound transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of organic hydroxy compound from one side of a membrane to the other.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901623", "lbl" : "regulation of lymphocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901624", "lbl" : "negative regulation of lymphocyte chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901652", "lbl" : "response to peptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901653", "lbl" : "cellular response to peptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901654", + "lbl" : "response to ketone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A response that results in a state of tolerance to ketone.", + "xrefs" : [ "GOC:mengo_curators", "PMID:23356676" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1901655", + "lbl" : "cellular response to ketone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901692", "lbl" : "regulation of compound eye retinal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis", "PMID:12021768" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901693", "lbl" : "negative regulation of compound eye retinal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis", "PMID:12021768" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901694", "lbl" : "positive regulation of compound eye retinal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis", "PMID:12021768" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901698", "lbl" : "response to nitrogen compound", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901699", "lbl" : "cellular response to nitrogen compound", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + }, + "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901706", "lbl" : "mesenchymal cell differentiation involved in bone development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state.", + "xrefs" : [ "GOC:TermGenie", "GOC:hjd", "PMID:21571217" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901861", "lbl" : "regulation of muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf", "PMID:23150719" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901862", "lbl" : "negative regulation of muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf", "PMID:23150719" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901863", "lbl" : "positive regulation of muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:yaf", "PMID:23150719" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901879", "lbl" : "regulation of protein depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein depolymerization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "PMID:12032137" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901880", "lbl" : "negative regulation of protein depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "PMID:12032137" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901881", "lbl" : "positive regulation of protein depolymerization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein depolymerization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "PMID:12032137" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901888", "lbl" : "regulation of cell junction assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell junction assembly.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901889", "lbl" : "negative regulation of cell junction assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901890", "lbl" : "positive regulation of cell junction assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell junction assembly.", + "xrefs" : [ "GOC:TermGenie" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901963", "lbl" : "regulation of cell proliferation involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_heart", "PMID:21419760" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1901964", "lbl" : "positive regulation of cell proliferation involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_heart", "PMID:21419760" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902017", "lbl" : "regulation of cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cilium assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:dph", "PMID:17719545" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902018", "lbl" : "negative regulation of cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:dph", "PMID:17719545" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902019", "lbl" : "regulation of cilium-dependent cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902020", "lbl" : "negative regulation of cilium-dependent cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902033", "lbl" : "regulation of hematopoietic stem cell proliferation", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_1902034", - "lbl" : "negative regulation of hematopoietic stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902034", + "lbl" : "negative regulation of hematopoietic stem cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902035", "lbl" : "positive regulation of hematopoietic stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902036", "lbl" : "regulation of hematopoietic stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902037", "lbl" : "negative regulation of hematopoietic stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902038", "lbl" : "positive regulation of hematopoietic stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23403623" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902105", "lbl" : "regulation of leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of leukocyte differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902106", "lbl" : "negative regulation of leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902107", "lbl" : "positive regulation of leukocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:add" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902115", "lbl" : "regulation of organelle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of organelle assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902116", "lbl" : "negative regulation of organelle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902117", "lbl" : "positive regulation of organelle assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of organelle assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902217", "lbl" : "erythrocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in an erythrocyte.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_apoptosis", "GOC:rl", "PMID:14569084" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902250", "lbl" : "regulation of erythrocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_apoptosis", "GOC:rl", "PMID:14569084" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902251", "lbl" : "negative regulation of erythrocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_apoptosis", "GOC:rl", "PMID:14569084" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902252", "lbl" : "positive regulation of erythrocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_apoptosis", "GOC:rl", "PMID:14569084" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902256", "lbl" : "regulation of apoptotic process involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_apoptosis", "PMID:16839542" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902257", "lbl" : "negative regulation of apoptotic process involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_apoptosis", "PMID:16839542" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902258", "lbl" : "positive regulation of apoptotic process involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_apoptosis", "PMID:16839542" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902262", "lbl" : "apoptotic process involved in blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that is involved in blood vessel morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:mtg_apoptosis", "PMID:16163358" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902275", "lbl" : "regulation of chromatin organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of chromatin organization.", + "xrefs" : [ "GOC:TermGenie", "GOC:bf", "GOC:vw", "GO_REF:0000058", "PMID:18314879" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902337", "lbl" : "regulation of apoptotic process involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:sart", "PMID:12202035" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902338", "lbl" : "negative regulation of apoptotic process involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:sart", "PMID:12202035" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902339", "lbl" : "positive regulation of apoptotic process involved in morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis.", + "xrefs" : [ "GOC:TermGenie", "GOC:sart", "PMID:12202035" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902340", "lbl" : "negative regulation of chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation.", + "xrefs" : [ "GOC:TermGenie", "PMID:23219725" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902369", + "lbl" : "negative regulation of RNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:bf", "PMID:16640457" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902414", "lbl" : "protein localization to cell junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a cell junction.", + "xrefs" : [ "GOC:TermGenie", "PMID:18332111" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902463", "lbl" : "protein localization to cell leading edge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a cell leading edge.", + "xrefs" : [ "GOC:TermGenie", "GOC:lb", "PMID:21543326" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902473", "lbl" : "regulation of protein localization to synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to synapse.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "PMID:22588719" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902474", "lbl" : "positive regulation of protein localization to synapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to synapse.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "PMID:22588719" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902488", + "lbl" : "cholangiocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a cholangiocyte.", + "xrefs" : [ "GOC:TermGenie", "PMID:22961800" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902489", + "lbl" : "hepatoblast apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a hepatoblast.", + "xrefs" : [ "GOC:TermGenie", "PMID:22412967" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902494", + "lbl" : "catalytic complex", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A protein complex which is capable of catalytic activity.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "PMID:8077207" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902495", + "lbl" : "transmembrane transporter complex", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "PMID:18024586" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902510", + "lbl" : "regulation of apoptotic DNA fragmentation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation.", + "xrefs" : [ "GOC:TermGenie", "GOC:hjd", "PMID:15572351", "PMID:15723341" ] + }, + "comments" : [ "DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341)." ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902511", + "lbl" : "negative regulation of apoptotic DNA fragmentation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation.", + "xrefs" : [ "GOC:TermGenie", "GOC:hjd", "PMID:15572351" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1902512", + "lbl" : "positive regulation of apoptotic DNA fragmentation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation.", + "xrefs" : [ "GOC:TermGenie", "GOC:hjd", "PMID:15572351" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902513", "lbl" : "regulation of organelle transport along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of organelle transport along microtubule.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "PMID:21147087" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902531", "lbl" : "regulation of intracellular signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of intracellular signal transduction.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:signaling", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902532", "lbl" : "negative regulation of intracellular signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GOC:signaling", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902533", "lbl" : "positive regulation of intracellular signal transduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:dph", "GOC:signaling", "GOC:tb" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902570", "lbl" : "protein localization to nucleolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a nucleolus.", + "xrefs" : [ "GOC:TermGenie", "PMID:22809626" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902679", "lbl" : "negative regulation of RNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.", + "xrefs" : [ "GO:jl", "GOC:TermGenie", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902680", "lbl" : "positive regulation of RNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process.", + "xrefs" : [ "GO:jl", "GOC:TermGenie", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902692", "lbl" : "regulation of neuroblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuroblast proliferation.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:21168496" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902738", "lbl" : "regulation of chondrocyte differentiation involved in endochondral bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:8662546" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902742", "lbl" : "apoptotic process involved in development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process that is involved in anatomical structure development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_apoptosis", "GOC:pg", "GO_REF:0000060" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902761", "lbl" : "positive regulation of chondrocyte development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chondrocyte development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16575901" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902809", "lbl" : "regulation of skeletal muscle fiber differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:17879321" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902810", "lbl" : "negative regulation of skeletal muscle fiber differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:17879321" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902811", "lbl" : "positive regulation of skeletal muscle fiber differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:17879321" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902816", "lbl" : "regulation of protein localization to microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to microtubule.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058", "PMID:23087209" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902817", "lbl" : "negative regulation of protein localization to microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058", "PMID:23087209" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902838", "lbl" : "regulation of nuclear migration along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23087209" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902839", "lbl" : "negative regulation of nuclear migration along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23087209" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902840", "lbl" : "positive regulation of nuclear migration along microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23087209" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902850", "lbl" : "microtubule cytoskeleton organization involved in mitosis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microtubule cytoskeleton organization that is involved in mitosis.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000060", "PMID:18799626" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902863", "lbl" : "regulation of embryonic camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902864", "lbl" : "negative regulation of embryonic camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902865", "lbl" : "positive regulation of embryonic camera-type eye development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902866", "lbl" : "regulation of retina development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of retina development in camera-type eye.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902867", "lbl" : "negative regulation of retina development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902868", "lbl" : "positive regulation of retina development in camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902875", "lbl" : "regulation of embryonic pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of embryonic pattern specification.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902876", "lbl" : "negative regulation of embryonic pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902877", "lbl" : "positive regulation of embryonic pattern specification", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16872597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902903", "lbl" : "regulation of supramolecular fiber organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of supramolecular fiber organization.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23921388" ] + }, + "comments" : [ "HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902904", "lbl" : "negative regulation of supramolecular fiber organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23921388" ] + }, + "comments" : [ "HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902905", "lbl" : "positive regulation of supramolecular fiber organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23921388" ] + }, + "comments" : [ "HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1902913", "lbl" : "positive regulation of neuroepithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:16916506" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903008", "lbl" : "organelle disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of an organelle into its constituent components.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000079" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903010", "lbl" : "regulation of bone development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of bone development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:22510437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903011", "lbl" : "negative regulation of bone development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of bone development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:22510437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903012", "lbl" : "positive regulation of bone development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of bone development.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:22510437" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903018", "lbl" : "regulation of glycoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23544079" ] + }, + "comments" : [ "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903019", "lbl" : "negative regulation of glycoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23544079" ] + }, + "comments" : [ "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903020", "lbl" : "positive regulation of glycoprotein metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:23544079" ] + }, + "comments" : [ "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903037", "lbl" : "regulation of leukocyte cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:21106532" ] + }, + "comments" : [ "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903038", "lbl" : "negative regulation of leukocyte cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:21106532" ] + }, + "comments" : [ "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903039", "lbl" : "positive regulation of leukocyte cell-cell adhesion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:21106532" ] + }, + "comments" : [ "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903045", "lbl" : "neural crest cell migration involved in sympathetic nervous system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any neural crest cell migration that is involved in sympathetic nervous system development.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000060", "PMID:19325129" ] + }, + "comments" : [ "Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903046", "lbl" : "meiotic cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is part of the meiotic cell cycle.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_cell_cycle", "GO_REF:0000060" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903047", "lbl" : "mitotic cell cycle process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process that is part of the mitotic cell cycle.", + "xrefs" : [ "GOC:TermGenie", "GOC:mtg_cell_cycle", "GO_REF:0000060" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903053", "lbl" : "regulation of extracellular matrix organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of extracellular matrix organization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:22357537" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903054", "lbl" : "negative regulation of extracellular matrix organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:22357537" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903055", "lbl" : "positive regulation of extracellular matrix organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:22357537" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903076", "lbl" : "regulation of protein localization to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:11602640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903077", "lbl" : "negative regulation of protein localization to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:11602640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903078", "lbl" : "positive regulation of protein localization to plasma membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:11602640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903115", "lbl" : "regulation of actin filament-based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of actin filament-based movement.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24798735" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903116", "lbl" : "positive regulation of actin filament-based movement", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of actin filament-based movement.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24798735" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903119", "lbl" : "protein localization to actin cytoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:24798735" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903120", "lbl" : "protein localization to actin filament bundle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:24798735" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903131", "lbl" : "mononuclear cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell.", + "xrefs" : [ "CL:0000842", "GOC:TermGenie", "GO_REF:0000086", "PMID:24759906" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903224", "lbl" : "regulation of endodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endodermal cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23154389" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903225", "lbl" : "negative regulation of endodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23154389" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903226", "lbl" : "positive regulation of endodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23154389" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903251", "lbl" : "multi-ciliated epithelial cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:sp", "GO_REF:0000086", "PMID:22231168", "PMID:24934224" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903292", "lbl" : "protein localization to Golgi membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:11378902" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903335", "lbl" : "regulation of vacuolar transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vacuolar transport.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903336", "lbl" : "negative regulation of vacuolar transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903337", "lbl" : "positive regulation of vacuolar transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vacuolar transport.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903353", "lbl" : "regulation of nucleus organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of nucleus organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:16943282" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903358", "lbl" : "regulation of Golgi organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of Golgi organization.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:17562788" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903379", "lbl" : "regulation of mitotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:9490640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903380", "lbl" : "positive regulation of mitotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:9490640" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903412", + "lbl" : "response to bile acid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000071", "PMID:21757002" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903413", + "lbl" : "cellular response to bile acid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000071", "PMID:21757002" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903429", "lbl" : "regulation of cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell maturation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17459944" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903430", "lbl" : "negative regulation of cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17459944" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903431", "lbl" : "positive regulation of cell maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell maturation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17459944" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903441", "lbl" : "protein localization to ciliary membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000087", "PMID:22139371" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903510", + "lbl" : "mucopolysaccharide metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways involving mucopolysaccharide.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000068", "PMID:4236091" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903522", "lbl" : "regulation of blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:10659969" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903523", "lbl" : "negative regulation of blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:10659969" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903524", "lbl" : "positive regulation of blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000058", "PMID:10659969" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903530", "lbl" : "regulation of secretion by cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of secretion by cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:pm", "GO_REF:0000058", "PMID:12130530" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903531", "lbl" : "negative regulation of secretion by cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:pm", "GO_REF:0000058", "PMID:12130530" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903532", "lbl" : "positive regulation of secretion by cell", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of secretion by cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:pm", "GO_REF:0000058", "PMID:12130530" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903537", "lbl" : "meiotic cell cycle process involved in oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any meiotic cell cycle process that is involved in oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GOC:jz", "GO_REF:0000060", "PMID:25212395" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903538", "lbl" : "regulation of meiotic cell cycle process involved in oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GOC:jz", "GO_REF:0000058", "PMID:25212395" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903541", "lbl" : "regulation of exosomal secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of exosomal secretion.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903542", "lbl" : "negative regulation of exosomal secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903543", "lbl" : "positive regulation of exosomal secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of exosomal secretion.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903551", "lbl" : "regulation of extracellular exosome assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903552", "lbl" : "negative regulation of extracellular exosome assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903553", "lbl" : "positive regulation of extracellular exosome assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24105262" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903561", "lbl" : "extracellular vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vesicle that is part of the extracellular region.", + "xrefs" : [ "GOC:TermGenie", "GOC:pm", "GO_REF:0000064", "PMID:24769233" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903564", "lbl" : "regulation of protein localization to cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to cilium.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903565", "lbl" : "negative regulation of protein localization to cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903566", "lbl" : "positive regulation of protein localization to cilium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to cilium.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903567", "lbl" : "regulation of protein localization to ciliary membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903568", "lbl" : "negative regulation of protein localization to ciliary membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903569", "lbl" : "positive regulation of protein localization to ciliary membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:22072986" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903624", + "lbl" : "regulation of DNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of DNA catabolic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:2001740" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903625", + "lbl" : "negative regulation of DNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:2001740" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903626", + "lbl" : "positive regulation of DNA catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of DNA catabolic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:2001740" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903697", "lbl" : "negative regulation of microvillus assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:22797597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903698", "lbl" : "positive regulation of microvillus assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of microvillus assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:22797597" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903701", "lbl" : "substantia propria of cornea development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000094", "PMID:12556382" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903702", "lbl" : "esophagus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000094", "ISBN:0-683-40008-8" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903706", "lbl" : "regulation of hemopoiesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hemopoiesis.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:20080761" ] + }, + "comments" : [ "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903707", "lbl" : "negative regulation of hemopoiesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:20080761" ] + }, + "comments" : [ "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903708", "lbl" : "positive regulation of hemopoiesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hemopoiesis.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:20080761" ] + }, + "comments" : [ "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903729", "lbl" : "regulation of plasma membrane organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of plasma membrane organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24514900" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903778", "lbl" : "protein localization to vacuolar membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:25378562" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903779", "lbl" : "regulation of cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac conduction.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_cardiac_conduct_nov11", "GOC:rph", "GO_REF:0000058", "PMID:12967627" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903780", "lbl" : "negative regulation of cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_cardiac_conduct_nov11", "GOC:rph", "GO_REF:0000058", "PMID:12967627" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903781", "lbl" : "positive regulation of cardiac conduction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac conduction.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_cardiac_conduct_nov11", "GOC:rph", "GO_REF:0000058", "PMID:12967627" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903825", + "lbl" : "organic acid transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which an organic acid is transported across a membrane.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000069" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903828", "lbl" : "negative regulation of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903829", "lbl" : "positive regulation of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of a protein localization.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903831", "lbl" : "signal transduction involved in cellular response to ammonium ion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any signal transduction that is involved in cellular response to ammonium ion.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000060", "PMID:16297994" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903847", "lbl" : "regulation of aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of aorta morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22269326" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903848", "lbl" : "negative regulation of aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22269326" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903849", "lbl" : "positive regulation of aorta morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22269326" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903867", "lbl" : "extraembryonic membrane development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000094", "ISBN:0073040584" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903903", "lbl" : "regulation of establishment of T cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of establishment of T cell polarity.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23575248" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903904", "lbl" : "negative regulation of establishment of T cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23575248" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903905", "lbl" : "positive regulation of establishment of T cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:23575248" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903941", "lbl" : "negative regulation of respiratory gaseous exchange", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22819705" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903942", "lbl" : "positive regulation of respiratory gaseous exchange", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22819705" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903943", + "lbl" : "regulation of hepatocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:8649852" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903944", + "lbl" : "negative regulation of hepatocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:8649852" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1903945", + "lbl" : "positive regulation of hepatocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:8649852" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903950", "lbl" : "negative regulation of AV node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_cardiac_conduct_nov11", "GOC:nc", "GO_REF:0000058", "PMID:25281747" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903951", "lbl" : "positive regulation of AV node cell action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of AV node cell action potential.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:mtg_cardiac_conduct_nov11", "GOC:nc", "GO_REF:0000058", "PMID:25281747" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903975", "lbl" : "regulation of glial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of glial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:19100238" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903976", "lbl" : "negative regulation of glial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:19100238" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1903977", "lbl" : "positive regulation of glial cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of glial cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:19100238" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904014", "lbl" : "response to serotonin", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_1904015", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:1505525" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904015", "lbl" : "cellular response to serotonin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:1505525" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904018", "lbl" : "positive regulation of vasculature development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vasculature development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:21472453" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904019", "lbl" : "epithelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in an epithelial cell.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000085", "PMID:19137015" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904026", "lbl" : "regulation of collagen fibril organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of collagen fibril organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25451920" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904027", "lbl" : "negative regulation of collagen fibril organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25451920" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904028", "lbl" : "positive regulation of collagen fibril organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of collagen fibril organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25451920" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904035", "lbl" : "regulation of epithelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19137015" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904036", "lbl" : "negative regulation of epithelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19137015" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904037", "lbl" : "positive regulation of epithelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19137015" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904054", + "lbl" : "regulation of cholangiocyte proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24434010" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904055", + "lbl" : "negative regulation of cholangiocyte proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24434010" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904056", + "lbl" : "positive regulation of cholangiocyte proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24434010" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904057", "lbl" : "negative regulation of sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17167094" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904058", "lbl" : "positive regulation of sensory perception of pain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of sensory perception of pain.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17167094" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904073", "lbl" : "regulation of trophectodermal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24508636" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904074", "lbl" : "negative regulation of trophectodermal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24508636" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904075", "lbl" : "positive regulation of trophectodermal cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24508636" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904106", "lbl" : "protein localization to microvillus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a microvillus.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "GO_REF:0000087", "PMID:25335890" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904145", "lbl" : "negative regulation of meiotic cell cycle process involved in oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22674394" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904146", "lbl" : "positive regulation of meiotic cell cycle process involved in oocyte maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22674394" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904170", "lbl" : "regulation of bleb assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of bleb assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:25651887" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904171", "lbl" : "negative regulation of bleb assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:25651887" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904172", "lbl" : "positive regulation of bleb assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of bleb assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:als", "GO_REF:0000058", "PMID:25651887" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904177", "lbl" : "regulation of adipose tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of adipose tissue development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23081848" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904178", "lbl" : "negative regulation of adipose tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23081848" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904179", "lbl" : "positive regulation of adipose tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of adipose tissue development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23081848" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904192", + "lbl" : "regulation of cholangiocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24498161" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904193", + "lbl" : "negative regulation of cholangiocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24498161" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904194", + "lbl" : "positive regulation of cholangiocyte apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24498161" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904204", "lbl" : "regulation of skeletal muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23470307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904205", "lbl" : "negative regulation of skeletal muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23470307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904206", "lbl" : "positive regulation of skeletal muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23470307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904238", "lbl" : "pericyte cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000086", "PMID:23868830" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904251", + "lbl" : "regulation of bile acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of bile acid metabolic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904252", + "lbl" : "negative regulation of bile acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904253", + "lbl" : "positive regulation of bile acid metabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process.", + "xrefs" : [ "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904269", "lbl" : "cell leading edge cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cell cortex of the leading edge of a cell.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "GO_REF:0000064", "PMID:25843030" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904304", + "lbl" : "regulation of gastro-intestinal system smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10821044" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904305", + "lbl" : "negative regulation of gastro-intestinal system smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10821044" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904306", + "lbl" : "positive regulation of gastro-intestinal system smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10821044" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904341", + "lbl" : "regulation of colon smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24170253" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904342", + "lbl" : "negative regulation of colon smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24170253" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904343", + "lbl" : "positive regulation of colon smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24170253" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904344", "lbl" : "regulation of gastric mucosal blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10807413" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904345", "lbl" : "negative regulation of gastric mucosal blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10807413" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904346", "lbl" : "positive regulation of gastric mucosal blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:10807413" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904347", + "lbl" : "regulation of small intestine smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:11991626" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904348", + "lbl" : "negative regulation of small intestine smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:11991626" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904349", + "lbl" : "positive regulation of small intestine smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:11991626" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904350", + "lbl" : "regulation of protein catabolic process in the vacuole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:25635054" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904351", + "lbl" : "negative regulation of protein catabolic process in the vacuole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:25635054" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904352", + "lbl" : "positive regulation of protein catabolic process in the vacuole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:25635054" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904375", "lbl" : "regulation of protein localization to cell periphery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to cell periphery.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18216290" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904376", "lbl" : "negative regulation of protein localization to cell periphery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18216290" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904377", "lbl" : "positive regulation of protein localization to cell periphery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18216290" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904396", "lbl" : "regulation of neuromuscular junction development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuromuscular junction development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:7722643" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904397", "lbl" : "negative regulation of neuromuscular junction development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:7722643" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904398", "lbl" : "positive regulation of neuromuscular junction development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:7722643" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904409", "lbl" : "regulation of secretory granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of secretory granule organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15039777" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904410", "lbl" : "negative regulation of secretory granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15039777" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904411", "lbl" : "positive regulation of secretory granule organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of secretory granule organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15039777" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904412", "lbl" : "regulation of cardiac ventricle development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac ventricle development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19590510" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904413", "lbl" : "negative regulation of cardiac ventricle development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19590510" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904414", "lbl" : "positive regulation of cardiac ventricle development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:19590510" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904456", "lbl" : "negative regulation of neuronal action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25126967" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904457", "lbl" : "positive regulation of neuronal action potential", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuronal action potential.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25126967" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904484", + "lbl" : "cloacal gland development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GOC:mr", "GO_REF:0000094", "PMID:18805421" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904491", "lbl" : "protein localization to ciliary transition zone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone.", + "xrefs" : [ "GOC:TermGenie", "GOC:kmv", "GO_REF:0000087", "PMID:21422230" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904587", "lbl" : "response to glycoprotein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:14597422" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904588", "lbl" : "cellular response to glycoprotein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000071", "PMID:14597422" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904606", "lbl" : "fat cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a fat cell.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000085", "PMID:17024416" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904649", "lbl" : "regulation of fat cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of fat cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17024416" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904650", "lbl" : "negative regulation of fat cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17024416" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904651", "lbl" : "positive regulation of fat cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17024416" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904653", "lbl" : "regulation of lung alveolus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lung alveolus development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23962064" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904654", "lbl" : "negative regulation of lung alveolus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23962064" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904655", "lbl" : "positive regulation of lung alveolus development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lung alveolus development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23962064" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904659", + "lbl" : "glucose transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which glucose is transported across a membrane.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000069", "PMID:9090050" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904675", "lbl" : "regulation of somatic stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of somatic stem cell division.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19409607" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904676", "lbl" : "negative regulation of somatic stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19409607" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904677", "lbl" : "positive regulation of somatic stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of somatic stem cell division.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19409607" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904680", + "lbl" : "peptide transmembrane transporter activity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Enables the transfer of a peptide from one side of a membrane to the other.", + "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000070" ] + }, + "xrefs" : [ { + "val" : "Reactome:R-HSA-1500817" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904691", + "lbl" : "negative regulation of type B pancreatic cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24055447" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904692", + "lbl" : "positive regulation of type B pancreatic cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:24055447" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904693", "lbl" : "midbrain morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process by which a midbrain is generated and organized.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000083", "PMID:21347250" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904697", + "lbl" : "regulation of acinar cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of acinar cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:9788538" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904698", + "lbl" : "negative regulation of acinar cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:9788538" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1904699", + "lbl" : "positive regulation of acinar cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:9788538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904705", "lbl" : "regulation of vascular associated smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23246467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904706", "lbl" : "negative regulation of vascular associated smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23246467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904707", "lbl" : "positive regulation of vascular associated smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23246467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904738", "lbl" : "vascular associated smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a vascular associated smooth muscle cell from one site to another.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000091", "PMID:20693317" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904746", "lbl" : "negative regulation of apoptotic process involved in development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22801495" ] + }, + "comments" : [ "U4PR86 in PMID:22801495 inferred from mutant phenotype" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904747", "lbl" : "positive regulation of apoptotic process involved in development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22801495" ] + }, + "comments" : [ "U4PR86 in PMID:22801495 inferred from mutant phenotype" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904748", "lbl" : "regulation of apoptotic process involved in development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apoptotic process involved in development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22801495" ] + }, + "comments" : [ "Q10943 in PMID:22801495, inferred from mutant phenotype" ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904749", "lbl" : "regulation of protein localization to nucleolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to nucleolus.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:24415760" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904750", "lbl" : "negative regulation of protein localization to nucleolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:24415760" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904751", "lbl" : "positive regulation of protein localization to nucleolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:24415760" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904752", "lbl" : "regulation of vascular associated smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:20693317" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904753", "lbl" : "negative regulation of vascular associated smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:20693317" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904754", "lbl" : "positive regulation of vascular associated smooth muscle cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:20693317" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904770", "lbl" : "intramembranous bone morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process by which an intramembranous bone is generated and organized.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000083", "PMID:26399686" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904776", "lbl" : "regulation of protein localization to cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to cell cortex.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17115027" ] + }, + "comments" : [ "An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904777", "lbl" : "negative regulation of protein localization to cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17115027" ] + }, + "comments" : [ "An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904778", "lbl" : "positive regulation of protein localization to cell cortex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17115027" ] + }, + "comments" : [ "An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904817", "lbl" : "serous membrane development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000094", "PMID:15840053" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904818", "lbl" : "visceral peritoneum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000094", "PMID:15840053" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904819", "lbl" : "parietal peritoneum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000094", "PMID:15840053" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904820", "lbl" : "peritoneum development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure.", + "xrefs" : [ "GOC:TermGenie", "GOC:dph", "GO_REF:0000094", "PMID:15840053" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904829", "lbl" : "regulation of aortic smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22034194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904830", "lbl" : "negative regulation of aortic smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22034194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904831", "lbl" : "positive regulation of aortic smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:22034194" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904888", "lbl" : "cranial skeletal system development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000094", "PMID:11262227" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904933", "lbl" : "regulation of cell proliferation in midbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:18953410", "PMID:24431302" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904934", "lbl" : "negative regulation of cell proliferation in midbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:18953410", "PMID:24431302" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904935", "lbl" : "positive regulation of cell proliferation in midbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:24431302" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904936", "lbl" : "interneuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of an interneuron from one site to another.", + "xrefs" : [ "GOC:TermGenie", "GOC:ah", "GO_REF:0000091", "PMID:18622031" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904937", "lbl" : "sensory neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a sensory neuron from one site to another.", + "xrefs" : [ "GOC:TermGenie", "GOC:ah", "GO_REF:0000091", "PMID:18622031" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904942", "lbl" : "regulation of cardiac ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac ventricle formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23575307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904943", "lbl" : "negative regulation of cardiac ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23575307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904944", "lbl" : "positive regulation of cardiac ventricle formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23575307" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904950", "lbl" : "negative regulation of establishment of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22761445" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904951", "lbl" : "positive regulation of establishment of protein localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of establishment of protein localization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:22761445" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904987", "lbl" : "regulation of endothelial cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial cell activation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:24255059" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904988", "lbl" : "negative regulation of endothelial cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:24255059" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1904989", "lbl" : "positive regulation of endothelial cell activation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial cell activation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:24255059" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905039", + "lbl" : "carboxylic acid transmembrane transport", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which carboxylic acid is transported across a membrane.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000069", "PMID:10869563" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905063", "lbl" : "regulation of vascular associated smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19088079" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905064", "lbl" : "negative regulation of vascular associated smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19088079" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905065", "lbl" : "positive regulation of vascular associated smooth muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:19088079" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905126", "lbl" : "regulation of axo-dendritic protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:20694152" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905127", "lbl" : "negative regulation of axo-dendritic protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:20694152" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905128", "lbl" : "positive regulation of axo-dendritic protein transport", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:20694152" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905139", "lbl" : "apical ectodermal ridge formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000081", "PMID:18359901", "PMID:9323126", "PMID:9596583" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905140", "lbl" : "regulation of apical ectodermal ridge formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18359901" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905141", "lbl" : "negative regulation of apical ectodermal ridge formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18359901" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905142", "lbl" : "positive regulation of apical ectodermal ridge formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18359901" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905146", + "lbl" : "lysosomal protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cellular protein catabolic process that takes place in a lysosome.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000062", "PMID:24334770" ] + }, + "comments" : [ "Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905147", "lbl" : "regulation of smooth muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:22161164" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905148", "lbl" : "negative regulation of smooth muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:22161164" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905149", "lbl" : "positive regulation of smooth muscle hypertrophy", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:22161164" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905153", "lbl" : "regulation of membrane invagination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of membrane invagination.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:26589353" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905154", "lbl" : "negative regulation of membrane invagination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:26589353" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905155", "lbl" : "positive regulation of membrane invagination", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of membrane invagination.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905165", + "lbl" : "regulation of lysosomal protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:23499937" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905166", + "lbl" : "negative regulation of lysosomal protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905167", + "lbl" : "positive regulation of lysosomal protein catabolic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905207", "lbl" : "regulation of cardiocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiocyte differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23069713" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905208", "lbl" : "negative regulation of cardiocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23069713" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905209", "lbl" : "positive regulation of cardiocyte differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:23069713" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905213", "lbl" : "negative regulation of mitotic chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:23219725" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905223", "lbl" : "epicardium morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The developmental process by which an epicardium is generated and organized.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000083", "PMID:18718461" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905268", "lbl" : "negative regulation of chromatin organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr", "GOC:vw", "GO_REF:0000058", "PMID:654321" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905269", "lbl" : "positive regulation of chromatin organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chromatin organization.", + "xrefs" : [ "GOC:TermGenie", "GOC:pr", "GOC:vw", "GO_REF:0000058", "PMID:654321" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905276", "lbl" : "regulation of epithelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial tube formation.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905277", "lbl" : "negative regulation of epithelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905278", "lbl" : "positive regulation of epithelial tube formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of epithelial tube formation.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905288", "lbl" : "vascular associated smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a vascular associated smooth muscle cell.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000085", "PMID:26493107" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905292", "lbl" : "regulation of neural crest cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neural crest cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:15073157" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905293", "lbl" : "negative regulation of neural crest cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:15073157" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905294", "lbl" : "positive regulation of neural crest cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:15073157" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905298", + "lbl" : "regulation of intestinal epithelial cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23904268" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905299", + "lbl" : "negative regulation of intestinal epithelial cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23904268" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1905300", + "lbl" : "positive regulation of intestinal epithelial cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23904268" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905304", "lbl" : "regulation of cardiac myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:16151019" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905305", "lbl" : "negative regulation of cardiac myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:16151019" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905306", "lbl" : "positive regulation of cardiac myofibril assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:16151019" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905310", "lbl" : "regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:17628518" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905311", "lbl" : "negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:17628518" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905312", "lbl" : "positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis", - "type" : "CLASS" - }, { + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000058", "PMID:17628518" ] + } + } + }, { "id" : "http://purl.obolibrary.org/obo/GO_1905315", "lbl" : "cell proliferation involved in endocardial cushion morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any cell proliferation that is involved in endocardial cushion morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:TermGenie", "GOC:rl", "GO_REF:0000060", "PMID:20652948" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905319", "lbl" : "mesenchymal stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a mesenchymal stem cell from one site to another.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000091", "PMID:24924806", "PMID:25181476" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905320", "lbl" : "regulation of mesenchymal stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26846297" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905321", "lbl" : "negative regulation of mesenchymal stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26846297" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905322", "lbl" : "positive regulation of mesenchymal stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26846297" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905330", "lbl" : "regulation of morphogenesis of an epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905331", "lbl" : "negative regulation of morphogenesis of an epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905332", "lbl" : "positive regulation of morphogenesis of an epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:25745997" ] + }, + "comments" : [ "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905349", "lbl" : "ciliary transition zone assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GO_REF:0000079", "PMID:21725307", "PMID:23644468", "PMID:24448408", "PMID:26595381", "PMID:26982032" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905351", "lbl" : "pericyte cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a pericyte cell from one site to another.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000091", "PMID:26268439" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905383", "lbl" : "protein localization to presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a presynapse.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:24449494" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905384", "lbl" : "regulation of protein localization to presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to presynapse.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:24449494" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905385", "lbl" : "negative regulation of protein localization to presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:24449494" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905386", "lbl" : "positive regulation of protein localization to presynapse", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:24449494" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905432", "lbl" : "regulation of retrograde trans-synaptic signaling by neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:19448629" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905433", "lbl" : "negative regulation of retrograde trans-synaptic signaling by neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:19448629" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905434", "lbl" : "positive regulation of retrograde trans-synaptic signaling by neuropeptide", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bf", "GO_REF:0000058", "PMID:19448629" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905453", "lbl" : "regulation of myeloid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905454", "lbl" : "negative regulation of myeloid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905455", "lbl" : "positive regulation of myeloid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905456", "lbl" : "regulation of lymphoid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905457", "lbl" : "negative regulation of lymphoid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905458", "lbl" : "positive regulation of lymphoid progenitor cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27010503" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905459", "lbl" : "regulation of vascular associated smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:26493107" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905460", "lbl" : "negative regulation of vascular associated smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:26493107" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905461", "lbl" : "positive regulation of vascular associated smooth muscle cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:26493107" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905475", "lbl" : "regulation of protein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to membrane.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:26911690" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905476", "lbl" : "negative regulation of protein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:26911690" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905477", "lbl" : "positive regulation of protein localization to membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to membrane.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:26911690" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905483", "lbl" : "regulation of motor neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of motor neuron migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:16516839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905484", "lbl" : "negative regulation of motor neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:16516839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905485", "lbl" : "positive regulation of motor neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of motor neuron migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:16516839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905492", "lbl" : "positive regulation of branching morphogenesis of a nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:16516839" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905503", "lbl" : "regulation of motile cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of motile cilium assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:25294941" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905504", "lbl" : "negative regulation of motile cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:25294941" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905505", "lbl" : "positive regulation of motile cilium assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of motile cilium assembly.", + "xrefs" : [ "GOC:TermGenie", "GOC:cilia", "GOC:krc", "GO_REF:0000058", "PMID:25294941" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905516", "lbl" : "positive regulation of fertilization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of fertilization.", + "xrefs" : [ "GOC:TermGenie", "GOC:hbye", "GO_REF:0000058", "PMID:27564576" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905517", "lbl" : "macrophage migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The orderly movement of a macrophage from one site to another.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000091", "PMID:25749876" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905521", "lbl" : "regulation of macrophage migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of macrophage migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25749876" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905522", "lbl" : "negative regulation of macrophage migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25749876" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905523", "lbl" : "positive regulation of macrophage migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of macrophage migration.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25749876" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905553", "lbl" : "regulation of blood vessel branching", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of blood vessel branching.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905554", "lbl" : "negative regulation of vessel branching", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905555", "lbl" : "positive regulation of blood vessel branching", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of blood vessel branching.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905557", "lbl" : "regulation of mitotic nuclear envelope disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18765790" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905558", "lbl" : "negative regulation of mitotic nuclear envelope disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18765790" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905559", "lbl" : "positive regulation of mitotic nuclear envelope disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:18765790" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905562", "lbl" : "regulation of vascular endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905563", "lbl" : "negative regulation of vascular endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905564", "lbl" : "positive regulation of vascular endothelial cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_telomere", "GOC:TermGenie", "GOC:nc", "GO_REF:0000058", "PMID:23201774" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905606", "lbl" : "regulation of presynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of presynapse assembly.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:25533483" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905607", "lbl" : "negative regulation of presynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:25533483" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905608", "lbl" : "positive regulation of presynapse assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of presynapse assembly.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:bc", "GO_REF:0000058", "PMID:25533483" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905627", "lbl" : "regulation of serotonin biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:25642596" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905628", "lbl" : "negative regulation of serotonin biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:25642596" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905629", "lbl" : "positive regulation of serotonin biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process.", + "xrefs" : [ "GOC:PARL", "GOC:TermGenie", "GOC:pad", "GO_REF:0000058", "PMID:25642596" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905632", "lbl" : "protein localization to euchromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within an euchromatin.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:20889714" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905633", "lbl" : "establishment of protein localization to euchromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The directed movement of a protein to a specific location in an euchromatin.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:20889714" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905634", "lbl" : "regulation of protein localization to chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to chromatin.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:20889714" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905651", "lbl" : "regulation of artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of artery morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:27389411" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905652", "lbl" : "negative regulation of artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:27389411" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905653", "lbl" : "positive regulation of artery morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of artery morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:27389411" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905671", "lbl" : "regulation of lysosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lysosome organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25561470" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905672", "lbl" : "negative regulation of lysosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25561470" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905673", "lbl" : "positive regulation of lysosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lysosome organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:25561470" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905690", "lbl" : "nucleus disassembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The disaggregation of a nucleus into its constituent components.", + "xrefs" : [ "GOC:TermGenie", "GOC:autophagy", "GOC:pr", "GO_REF:0000079" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905720", "lbl" : "cytoplasmic microtubule bundle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any microtubule bundle that is part of a cytoplasm.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000064", "PMID:11007487", "PMID:26124291" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905755", "lbl" : "protein localization to cytoplasmic microtubule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000087", "PMID:15177031" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905770", "lbl" : "regulation of mesodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23765923" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905771", "lbl" : "negative regulation of mesodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23765923" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905772", "lbl" : "positive regulation of mesodermal cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23765923" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905806", "lbl" : "regulation of synapse pruning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of synapse pruning.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27779093" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905807", "lbl" : "negative regulation of synapse pruning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27779093" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905808", "lbl" : "positive regulation of synapse pruning", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of synapse pruning.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27779093" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905809", "lbl" : "negative regulation of synapse organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27779093" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905821", "lbl" : "positive regulation of chromosome condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chromosome condensation.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:17268547" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905833", "lbl" : "negative regulation of microtubule nucleation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:27689799" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905871", "lbl" : "regulation of protein localization to cell leading edge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26324884" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905872", "lbl" : "negative regulation of protein localization to cell leading edge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26324884" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905873", "lbl" : "positive regulation of protein localization to cell leading edge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26324884" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905879", "lbl" : "regulation of oogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of oogenesis.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26434723" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905880", "lbl" : "negative regulation of oogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26434723" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905881", "lbl" : "positive regulation of oogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of oogenesis.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:26434723" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905899", "lbl" : "regulation of smooth muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of smooth muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:14709716" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905900", "lbl" : "negative regulation of smooth muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:14709716" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905901", "lbl" : "positive regulation of smooth muscle tissue development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development.", + "xrefs" : [ "GOC:TermGenie", "GOC:bhm", "GO_REF:0000058", "PMID:14709716" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905902", "lbl" : "regulation of mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesoderm formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23939491" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905903", "lbl" : "negative regulation of mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23939491" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905904", "lbl" : "positive regulation of mesoderm formation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesoderm formation.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:23939491" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905936", "lbl" : "regulation of germ cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of germ cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905937", "lbl" : "negative regulation of germ cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905938", "lbl" : "positive regulation of germ cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of germ cell proliferation.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905939", "lbl" : "regulation of gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of gonad development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905940", "lbl" : "negative regulation of gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905941", "lbl" : "positive regulation of gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gonad development.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:15342467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905952", "lbl" : "regulation of lipid localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lipid localization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17564681" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905953", "lbl" : "negative regulation of lipid localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17564681" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905954", "lbl" : "positive regulation of lipid localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lipid localization.", + "xrefs" : [ "GOC:TermGenie", "GO_REF:0000058", "PMID:17564681" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905955", "lbl" : "negative regulation of endothelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:25961718" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1905956", "lbl" : "positive regulation of endothelial tube morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis.", + "xrefs" : [ "GOC:BHF", "GOC:BHF_miRNA", "GOC:TermGenie", "GOC:rph", "GO_REF:0000058", "PMID:25961718" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990009", "lbl" : "retinal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a retinal cell.", + "xrefs" : [ "GOC:mtg_apoptosis", "PMID:15558487", "PMID:24664675" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990010", "lbl" : "compound eye retinal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any apoptotic process in a compound eye retinal cell.", + "xrefs" : [ "GOC:mtg_apoptosis", "PMID:12021768" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990182", "lbl" : "exosomal secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.", + "xrefs" : [ "GOC:hjd", "PMID:10572093", "PMID:12154376", "PMID:16773132", "PMID:18617898" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990280", "lbl" : "RNA localization to chromatin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin.", + "xrefs" : [ "GOC:dos", "GOC:mah", "PMID:22582262" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990351", + "lbl" : "transporter complex", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells.", + "xrefs" : [ "GOC:bhm", "PMID:15449578" ] + }, + "comments" : [ "An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay)." ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990502", "lbl" : "dense core granule maturation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.", + "xrefs" : [ "GOC:kmv", "PMID:22654674" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990705", + "lbl" : "cholangiocyte proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water.", + "xrefs" : [ "PMID:24434010" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990748", + "lbl" : "cellular detoxification", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.", + "xrefs" : [ "GOC:vw" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990765", + "lbl" : "colon smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum.", + "xrefs" : [ "PMID:24170253" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990768", "lbl" : "gastric mucosal blood circulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products.", + "xrefs" : [ "PMID:10807413" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990770", + "lbl" : "small intestine smooth muscle contraction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine.", + "xrefs" : [ "PMID:11991626" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990778", "lbl" : "protein localization to cell periphery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A process in which a protein is transported to, or maintained in, the cell periphery.", + "xrefs" : [ "PMID:18216290" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990849", "lbl" : "vacuolar localization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell.", + "xrefs" : [ "PMID:26283797" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_1990863", + "lbl" : "acinar cell proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus).", + "xrefs" : [ "PMID:9788538" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990874", "lbl" : "vascular associated smooth muscle cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.", + "xrefs" : [ "PMID:23246467" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990904", "lbl" : "ribonucleoprotein complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A macromolecular complex that contains both RNA and protein molecules.", + "xrefs" : [ "GOC:krc", "GOC:vesicles" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Ribonucleoprotein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_1990917", "lbl" : "ooplasm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cytoplasm of an ovum.", + "xrefs" : [ "PMID:19022436" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000026", "lbl" : "regulation of multicellular organismal development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of multicellular organismal development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000027", "lbl" : "regulation of animal organ morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of animal organ morphogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000035", "lbl" : "regulation of stem cell division", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of stem cell division.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000068", "lbl" : "regulation of defense response to insect", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of defense response to insect.", + "xrefs" : [ "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000074", + "lbl" : "regulation of type B pancreatic cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of pancreatic B cell development.", + "xrefs" : [ "GOC:obol", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000077", + "lbl" : "negative regulation of type B pancreatic cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development.", + "xrefs" : [ "GOC:obol", "GOC:yaf" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000078", + "lbl" : "positive regulation of type B pancreatic cell development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development.", + "xrefs" : [ "GOC:obol", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000106", "lbl" : "regulation of leukocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000107", "lbl" : "negative regulation of leukocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000108", "lbl" : "positive regulation of leukocyte apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000109", "lbl" : "regulation of macrophage apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of macrophage apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000110", "lbl" : "negative regulation of macrophage apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000111", "lbl" : "positive regulation of macrophage apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000114", "lbl" : "regulation of establishment of cell polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of establishment of cell polarity.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000136", "lbl" : "regulation of cell proliferation involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000137", "lbl" : "negative regulation of cell proliferation involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000138", "lbl" : "positive regulation of cell proliferation involved in heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000145", "lbl" : "regulation of cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell motility.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000146", "lbl" : "negative regulation of cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000147", "lbl" : "positive regulation of cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell motility.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000155", "lbl" : "positive regulation of cilium-dependent cell motility", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility.", + "xrefs" : [ "GOC:cilia", "GOC:jl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000172", "lbl" : "regulation of branching morphogenesis of a nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000173", "lbl" : "negative regulation of branching morphogenesis of a nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000174", "lbl" : "regulation of pro-T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of pro-T cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000175", "lbl" : "negative regulation of pro-T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000176", "lbl" : "positive regulation of pro-T cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000177", "lbl" : "regulation of neural precursor cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000178", "lbl" : "negative regulation of neural precursor cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000179", "lbl" : "positive regulation of neural precursor cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000181", "lbl" : "negative regulation of blood vessel morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis.", + "xrefs" : [ "GOC:dph", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000194", "lbl" : "regulation of female gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of female gonad development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000195", "lbl" : "negative regulation of female gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000196", "lbl" : "positive regulation of female gonad development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of female gonad development.", + "xrefs" : [ "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000226", + "lbl" : "regulation of pancreatic A cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000227", + "lbl" : "negative regulation of pancreatic A cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000228", + "lbl" : "positive regulation of pancreatic A cell differentiation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000241", "lbl" : "regulation of reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of reproductive process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000242", "lbl" : "negative regulation of reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000243", "lbl" : "positive regulation of reproductive process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of reproductive process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000248", "lbl" : "negative regulation of establishment or maintenance of neuroblast polarity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000269", "lbl" : "regulation of fibroblast apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000270", "lbl" : "negative regulation of fibroblast apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000271", "lbl" : "positive regulation of fibroblast apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000278", "lbl" : "regulation of DNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of DNA biosynthetic process.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000279", "lbl" : "negative regulation of DNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000287", "lbl" : "positive regulation of myotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myotome development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000288", "lbl" : "positive regulation of myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myoblast proliferation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000290", "lbl" : "regulation of myotome development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myotome development.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000291", "lbl" : "regulation of myoblast proliferation", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000351", - "lbl" : "regulation of endothelial cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myoblast proliferation.", + "xrefs" : [ "GOC:mah" ] + } + } }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000352", - "lbl" : "negative regulation of endothelial cell apoptotic process", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/GO_2000292", + "lbl" : "regulation of defecation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of defecation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000353", - "lbl" : "positive regulation of endothelial cell apoptotic process", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/GO_2000293", + "lbl" : "negative regulation of defecation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of defecation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { - "id" : "http://purl.obolibrary.org/obo/GO_2000374", + "id" : "http://purl.obolibrary.org/obo/GO_2000294", + "lbl" : "positive regulation of defecation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of defecation.", + "xrefs" : [ "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000351", + "lbl" : "regulation of endothelial cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process.", + "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000352", + "lbl" : "negative regulation of endothelial cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000353", + "lbl" : "positive regulation of endothelial cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.", + "xrefs" : [ "GOC:BHF", "GOC:mah", "GOC:mtg_apoptosis" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000374", "lbl" : "regulation of oxygen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of oxygen metabolic process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000375", "lbl" : "negative regulation of oxygen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000376", "lbl" : "positive regulation of oxygen metabolic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000380", "lbl" : "regulation of mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000381", "lbl" : "negative regulation of mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000382", "lbl" : "positive regulation of mesoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000383", "lbl" : "regulation of ectoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of ectoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000384", "lbl" : "negative regulation of ectoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000385", "lbl" : "positive regulation of ectoderm development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of ectoderm development.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000401", "lbl" : "regulation of lymphocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of lymphocyte migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000402", "lbl" : "negative regulation of lymphocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000403", "lbl" : "positive regulation of lymphocyte migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of lymphocyte migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000404", "lbl" : "regulation of T cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of T cell migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000405", "lbl" : "negative regulation of T cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000406", "lbl" : "positive regulation of T cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of T cell migration.", + "xrefs" : [ "GOC:mah" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000471", "lbl" : "regulation of hematopoietic stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000472", "lbl" : "negative regulation of hematopoietic stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000473", "lbl" : "positive regulation of hematopoietic stem cell migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000495", "lbl" : "regulation of cell proliferation involved in compound eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000496", "lbl" : "negative regulation of cell proliferation involved in compound eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000497", "lbl" : "positive regulation of cell proliferation involved in compound eye morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000508", "lbl" : "regulation of dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000509", "lbl" : "negative regulation of dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000510", "lbl" : "positive regulation of dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000527", "lbl" : "regulation of myeloid dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000528", "lbl" : "negative regulation of myeloid dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000529", "lbl" : "positive regulation of myeloid dendritic cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000542", "lbl" : "negative regulation of gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000543", "lbl" : "positive regulation of gastrulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of gastrulation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000547", "lbl" : "regulation of dendritic cell dendrite assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000548", "lbl" : "negative regulation of dendritic cell dendrite assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000549", "lbl" : "positive regulation of dendritic cell dendrite assembly", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000573", "lbl" : "positive regulation of DNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000647", "lbl" : "negative regulation of stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000648", "lbl" : "positive regulation of stem cell proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of stem cell proliferation.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000668", "lbl" : "regulation of dendritic cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000669", "lbl" : "negative regulation of dendritic cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000670", "lbl" : "positive regulation of dendritic cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000671", "lbl" : "regulation of motor neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000672", "lbl" : "negative regulation of motor neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000673", "lbl" : "positive regulation of motor neuron apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000674", + "lbl" : "regulation of type B pancreatic cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000675", + "lbl" : "negative regulation of type B pancreatic cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2000676", + "lbl" : "positive regulation of type B pancreatic cell apoptotic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000690", "lbl" : "regulation of cardiac muscle cell myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000691", "lbl" : "negative regulation of cardiac muscle cell myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000700", "lbl" : "positive regulation of cardiac muscle cell myoblast differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000725", "lbl" : "regulation of cardiac muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000726", "lbl" : "negative regulation of cardiac muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000727", "lbl" : "positive regulation of cardiac muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000736", "lbl" : "regulation of stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of stem cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000737", "lbl" : "negative regulation of stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000738", "lbl" : "positive regulation of stem cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of stem cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000790", "lbl" : "regulation of mesenchymal cell proliferation involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.", + "xrefs" : [ "PMID:21513708" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000791", "lbl" : "negative regulation of mesenchymal cell proliferation involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.", + "xrefs" : [ "PMID:21513708" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000792", "lbl" : "positive regulation of mesenchymal cell proliferation involved in lung development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.", + "xrefs" : [ "PMID:21513708" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000794", "lbl" : "regulation of epithelial cell proliferation involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.", + "xrefs" : [ "PMID:21513708" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000795", "lbl" : "negative regulation of epithelial cell proliferation involved in lung morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.", + "xrefs" : [ "PMID:21513708" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000818", "lbl" : "negative regulation of myoblast proliferation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000826", "lbl" : "regulation of heart morphogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of heart morphogenesis.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000831", "lbl" : "regulation of steroid hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of steroid hormone secretion.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000832", "lbl" : "negative regulation of steroid hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000833", "lbl" : "positive regulation of steroid hormone secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000834", "lbl" : "regulation of androgen secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of androgen secretion.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000835", "lbl" : "negative regulation of androgen secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion.", + "xrefs" : [ "GOC:sl" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2000836", "lbl" : "positive regulation of androgen secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of androgen secretion.", + "xrefs" : [ "GOC:sl" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_2001012", + "lbl" : "mesenchymal cell differentiation involved in renal system development", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state.", + "xrefs" : [ "GOC:mtg_kidney_jan10", "GOC:obol", "GOC:yaf" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001014", "lbl" : "regulation of skeletal muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001015", "lbl" : "negative regulation of skeletal muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001016", "lbl" : "positive regulation of skeletal muscle cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001026", "lbl" : "regulation of endothelial cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001027", "lbl" : "negative regulation of endothelial cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001028", "lbl" : "positive regulation of endothelial cell chemotaxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.", + "xrefs" : [ "GOC:BHF" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001053", "lbl" : "regulation of mesenchymal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001054", "lbl" : "negative regulation of mesenchymal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001055", "lbl" : "positive regulation of mesenchymal cell apoptotic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process.", + "xrefs" : [ "GOC:mtg_apoptosis", "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001141", "lbl" : "regulation of RNA biosynthetic process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of RNA biosynthetic process.", + "xrefs" : [ "GOC:dph" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001198", "lbl" : "regulation of dendritic cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of dendritic cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001199", "lbl" : "negative regulation of dendritic cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001200", "lbl" : "positive regulation of dendritic cell differentiation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001204", "lbl" : "regulation of osteoclast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of osteoclast development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001205", "lbl" : "negative regulation of osteoclast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001206", "lbl" : "positive regulation of osteoclast development", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of osteoclast development.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001212", "lbl" : "regulation of vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of vasculogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001213", "lbl" : "negative regulation of vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001214", "lbl" : "positive regulation of vasculogenesis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of vasculogenesis.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001222", "lbl" : "regulation of neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of neuron migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001223", "lbl" : "negative regulation of neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001224", "lbl" : "positive regulation of neuron migration", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of neuron migration.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001233", "lbl" : "regulation of apoptotic signaling pathway", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.", + "xrefs" : [ "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001234", "lbl" : "negative regulation of apoptotic signaling pathway", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.", + "xrefs" : [ "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001235", "lbl" : "positive regulation of apoptotic signaling pathway", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.", + "xrefs" : [ "GOC:mtg_apoptosis" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001251", "lbl" : "negative regulation of chromosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/GO_2001252", "lbl" : "positive regulation of chromosome organization", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any process that activates or increases the frequency, rate or extent of chromosome organization.", + "xrefs" : [ "GOC:obol" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/NBO_0000073", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1", "lbl" : "root", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:30365038" + }, { + "val" : "PMID:32761142" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_117570", "lbl" : "Teleostomi", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_117571", "lbl" : "Euteleostomi", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1206794", "lbl" : "Ecdysozoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_131209", "lbl" : "Zygnemophyceae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_131221", "lbl" : "Streptophytina", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_131567", "lbl" : "cellular organisms", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1329799", "lbl" : "Archelosauria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:22839753" + }, { + "val" : "PMID:25450099" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1338369", "lbl" : "Dipnotetrapodomorpha", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_142796", "lbl" : "Eumycetozoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11062127" + }, { + "val" : "PMID:9342353" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1437010", + "lbl" : "Boreoeutheria", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11743200" + }, { + "val" : "PMID:11791233" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1437180", "lbl" : "Acrogymnospermae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1445966", "lbl" : "Gnetidae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_147537", "lbl" : "Saccharomycotina", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_147554", "lbl" : "Schizosaccharomycetes", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_186623", "lbl" : "Actinopteri", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_197562", "lbl" : "Pancrustacea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:10874751" + }, { + "val" : "PMID:11557979" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_197563", "lbl" : "Mandibulata", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11557979" + }, { + "val" : "PMID:9727836" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2", "lbl" : "Bacteria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:11" + }, { + "val" : "PMID:10425795" + }, { + "val" : "PMID:10425796" + }, { + "val" : "PMID:10425797" + }, { + "val" : "PMID:10490293" + }, { + "val" : "PMID:10843050" + }, { + "val" : "PMID:10939651" + }, { + "val" : "PMID:10939673" + }, { + "val" : "PMID:10939677" + }, { + "val" : "PMID:11211268" + }, { + "val" : "PMID:11321083" + }, { + "val" : "PMID:11321113" + }, { + "val" : "PMID:11411719" + }, { + "val" : "PMID:11540071" + }, { + "val" : "PMID:11542017" + }, { + "val" : "PMID:11542087" + }, { + "val" : "PMID:11760965" + }, { + "val" : "PMID:12054223" + }, { + "val" : "PMID:2112744" + }, { + "val" : "PMID:270744" + }, { + "val" : "PMID:32628106" + }, { + "val" : "PMID:36748408" + }, { + "val" : "PMID:7520741" + }, { + "val" : "PMID:8123559" + }, { + "val" : "PMID:8186100" + }, { + "val" : "PMID:8590690" + }, { + "val" : "PMID:9103655" + }, { + "val" : "PMID:9336922" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2058185", "lbl" : "Dictyosteliaceae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:29367151" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2058949", "lbl" : "Dictyosteliales", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:29367151" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_207598", + "lbl" : "Homininae", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2157", "lbl" : "Archaea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:11" + }, { + "val" : "PMID:10425795" + }, { + "val" : "PMID:10425796" + }, { + "val" : "PMID:10425797" + }, { + "val" : "PMID:10490293" + }, { + "val" : "PMID:10843050" + }, { + "val" : "PMID:10939651" + }, { + "val" : "PMID:10939673" + }, { + "val" : "PMID:10939677" + }, { + "val" : "PMID:11211268" + }, { + "val" : "PMID:11321083" + }, { + "val" : "PMID:11321113" + }, { + "val" : "PMID:11411719" + }, { + "val" : "PMID:11540071" + }, { + "val" : "PMID:11541975" + }, { + "val" : "PMID:11542064" + }, { + "val" : "PMID:11542149" + }, { + "val" : "PMID:11760965" + }, { + "val" : "PMID:12054223" + }, { + "val" : "PMID:2112744" + }, { + "val" : "PMID:25527841" + }, { + "val" : "PMID:270744" + }, { + "val" : "PMID:32628106" + }, { + "val" : "PMID:36748408" + }, { + "val" : "PMID:8123559" + }, { + "val" : "PMID:8590690" + }, { + "val" : "PMID:9103655" + }, { + "val" : "PMID:9336922" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2605435", "lbl" : "Evosea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2611352", "lbl" : "Discoba", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2684882", "lbl" : "Zygnematophycidae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2698737", "lbl" : "Sar", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_2759", "lbl" : "Eukaryota", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:23020233" + }, { + "val" : "PMID:30257078" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_314146", + "lbl" : "Euarchontoglires", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11214319" + }, { + "val" : "PMID:12082125" + }, { + "val" : "PMID:12878460" + }, { + "val" : "PMID:15522813" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_314293", + "lbl" : "Simiiformes", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_314295", + "lbl" : "Hominoidea", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3176", "lbl" : "Zygnematales", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3193", "lbl" : "Embryophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_32443", "lbl" : "Teleostei", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_32523", "lbl" : "Tetrapoda", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_32524", "lbl" : "Amniota", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_32525", "lbl" : "Theria ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_32561", "lbl" : "Sauria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33083", "lbl" : "Dictyostelia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11062127" + }, { + "val" : "PMID:29367151" + }, { + "val" : "PMID:9342353" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33090", "lbl" : "Viridiplantae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:16248873" + }, { + "val" : "PMID:30257078" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3312", "lbl" : "Coniferophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33154", "lbl" : "Opisthokonta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33208", "lbl" : "Metazoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33213", "lbl" : "Bilateria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33317", "lbl" : "Protostomia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33511", "lbl" : "Deuterostomia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33630", "lbl" : "Alveolata", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_33682", "lbl" : "Euglenozoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3372", "lbl" : "Gnetopsida", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3378", "lbl" : "Gnetales", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_3398", "lbl" : "Magnoliopsida", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:25249442" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_34346", "lbl" : "Schizosaccharomycetales", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_35493", "lbl" : "Streptophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_376913", + "lbl" : "Haplorrhini", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_38254", "lbl" : "Glaucocystophyceae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_40674", "lbl" : "Mammalia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_41665", "lbl" : "Neopterygii", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_436486", "lbl" : "Dinosauria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_436489", "lbl" : "Saurischia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_436491", "lbl" : "Theropoda", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_436492", "lbl" : "Coelurosauria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_451864", "lbl" : "Dikarya", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:15689432" + }, { + "val" : "PMID:16151185" + }, { + "val" : "PMID:17010206" + }, { + "val" : "PMID:17051209" + }, { + "val" : "PMID:17572334" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_451866", "lbl" : "Taphrinomycotina", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4751", "lbl" : "Fungi", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:11062127" + }, { + "val" : "PMID:12684019" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4890", "lbl" : "Ascomycota", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:17572334" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4891", "lbl" : "Saccharomycetes", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4892", "lbl" : "Saccharomycetales", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4893", "lbl" : "Saccharomycetaceae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4894", "lbl" : "Schizosaccharomycetaceae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4895", "lbl" : "Schizosaccharomyces", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4896", "lbl" : "Schizosaccharomyces pombe", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4930", "lbl" : "Saccharomyces", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_4932", "lbl" : "Saccharomyces cerevisiae", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_50557", "lbl" : "Insecta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_554915", "lbl" : "Amoebozoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:23020233" + }, { + "val" : "PMID:30257078" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_5782", "lbl" : "Dictyostelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + }, { + "val" : "PMID:29367151" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_58023", "lbl" : "Tracheophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_58024", "lbl" : "Spermatophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_6072", "lbl" : "Eumetazoa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_6656", "lbl" : "Arthropoda", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_6960", "lbl" : "Hexapoda", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_716545", "lbl" : "saccharomyceta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_7711", "lbl" : "Chordata", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_7742", "lbl" : "Vertebrata ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_7776", "lbl" : "Gnathostomata ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_78536", "lbl" : "Euphyllophyta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_7898", "lbl" : "Actinopterygii", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_8287", "lbl" : "Sarcopterygii", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_8457", "lbl" : "Sauropsida", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_8492", "lbl" : "Archosauria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_8782", "lbl" : "Aves", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_88770", "lbl" : "Panarthropoda", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_89593", "lbl" : "Craniata ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9347", + "lbl" : "Eutheria", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9443", + "lbl" : "Primates", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9526", + "lbl" : "Catarrhini", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9604", + "lbl" : "Hominidae", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9605", + "lbl" : "Homo", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/NCBITaxon_9606", + "lbl" : "Homo sapiens", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "GC_ID:1" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/PATO_0000407", "type" : "CLASS" @@ -15818,12 +44881,18 @@ }, { "id" : "http://purl.obolibrary.org/obo/PATO_0000964", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0000998", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001171", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001375", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0001377", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001393", "type" : "CLASS" @@ -15851,12 +44920,18 @@ }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001690", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0001735", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001736", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001748", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0001873", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0001908", "type" : "CLASS" @@ -15872,6 +44947,9 @@ }, { "id" : "http://purl.obolibrary.org/obo/PATO_0002045", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0002064", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0002078", "type" : "CLASS" @@ -15902,6 +44980,9 @@ }, { "id" : "http://purl.obolibrary.org/obo/PATO_0002462", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PATO_0002468", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PATO_0002478", "type" : "CLASS" @@ -16118,6 +45199,9 @@ }, { "id" : "http://purl.obolibrary.org/obo/PR_000007858", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/PR_000009054", + "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/PR_000009127", "type" : "CLASS" @@ -16130,154 +45214,952 @@ }, { "id" : "http://purl.obolibrary.org/obo/PR_000016043", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/SO_0000001", + "lbl" : "region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids.", + "xrefs" : [ "SO:ke" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/SO_0000110", + "lbl" : "sequence_feature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any extent of continuous biological sequence.", + "xrefs" : [ "LAMHDI:mb", "SO:ke" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/SO_0000704", + "lbl" : "gene", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions.", + "xrefs" : [ "SO:immuno_workshop" ] + }, + "comments" : [ "This term is mapped to MGED. Do not obsolete without consulting MGED ontology. A gene may be considered as a unit of inheritance." ], + "xrefs" : [ { + "val" : "http://en.wikipedia.org/wiki/Gene" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/SO_0001260", "lbl" : "sequence_collection", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of discontinuous sequences.", + "xrefs" : [ "SO:ke" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/SO_0001411", + "lbl" : "biological_region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region defined by its disposition to be involved in a biological process.", + "xrefs" : [ "SO:cb" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/SO_0005855", + "lbl" : "gene_group", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of related genes.", + "xrefs" : [ "SO:ma" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000000", "lbl" : "processual entity", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity.", + "xrefs" : [ "span:ProcessualEntity" ] + }, + "xrefs" : [ { + "val" : "BFO:0000003" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000005", "lbl" : "chemosensory organ", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "lbl" : "islet of Langerhans", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The clusters of hormone-producing cells that are scattered throughout the pancreas.", + "xrefs" : [ "MA:0000127", "MESH:A03.734.414", "MP:0005215" ] + }, + "xrefs" : [ { + "val" : "AAO:0010406" + }, { + "val" : "BTO:0000991" + }, { + "val" : "CALOHA:TS-0741" + }, { + "val" : "EFO:0000856" + }, { + "val" : "EMAPA:32927" + }, { + "val" : "EV:0100130" + }, { + "val" : "FMA:16016" + }, { + "val" : "GAID:324" + }, { + "val" : "MA:0000127" + }, { + "val" : "MAT:0000076" + }, { + "val" : "MESH:D007515" + }, { + "val" : "MIAA:0000076" + }, { + "val" : "NCIT:C12608" + }, { + "val" : "VHOG:0000646" + }, { + "val" : "Wikipedia:Islets_of_Langerhans" + }, { + "val" : "XAO:0000159" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000009", "lbl" : "submucosa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Submucosa" ] + }, + "xrefs" : [ { + "val" : "BTO:0002107" + }, { + "val" : "FMA:85391" + }, { + "val" : "FMA:85392" + }, { + "val" : "NCIT:C13167" + }, { + "val" : "SCTID:68439008" + }, { + "val" : "Wikipedia:Submucosa" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000010", "lbl" : "peripheral nervous system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.", + "xrefs" : [ "GO:0007422" ] + }, + "xrefs" : [ { + "val" : "AAO:0000429" + }, { + "val" : "BAMS:PNS" + }, { + "val" : "BILA:0000081" + }, { + "val" : "BIRNLEX:1111" + }, { + "val" : "BTO:0001028" + }, { + "val" : "CALOHA:TS-0808" + }, { + "val" : "EFO:0000891" + }, { + "val" : "EHDAA2:0001445" + }, { + "val" : "EHDAA:2893" + }, { + "val" : "EMAPA:16665" + }, { + "val" : "EV:0100335" + }, { + "val" : "FMA:9903" + }, { + "val" : "GAID:715" + }, { + "val" : "MA:0000218" + }, { + "val" : "MAT:0000338" + }, { + "val" : "MESH:D017933" + }, { + "val" : "MIAA:0000338" + }, { + "val" : "NCIT:C12465" + }, { + "val" : "SCTID:362292005" + }, { + "val" : "TAO:0000142" + }, { + "val" : "VHOG:0000399" + }, { + "val" : "Wikipedia:Peripheral_nervous_system" + }, { + "val" : "XAO:0000178" + }, { + "val" : "ZFA:0000142" + }, { + "val" : "neuronames:3232" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000013", "lbl" : "sympathetic nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO].", + "xrefs" : [ "GO:0048485" ] + }, + "xrefs" : [ { + "val" : "AAO:0010487" + }, { + "val" : "BIRNLEX:2516" + }, { + "val" : "BTO:0001832" + }, { + "val" : "CALOHA:TS-2050" + }, { + "val" : "EFO:0000893" + }, { + "val" : "EHDAA2:0001971" + }, { + "val" : "EHDAA:3769" + }, { + "val" : "EMAPA:16985" + }, { + "val" : "FMA:9906" + }, { + "val" : "GAID:710" + }, { + "val" : "MA:0000225" + }, { + "val" : "MESH:D013564" + }, { + "val" : "MIAA:0000100" + }, { + "val" : "NCIT:C12795" + }, { + "val" : "SCTID:362484004" + }, { + "val" : "TAO:0001576" + }, { + "val" : "VHOG:0000384" + }, { + "val" : "Wikipedia:Sympathetic_nervous_system" + }, { + "val" : "ZFA:0001576" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000014", "lbl" : "zone of skin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis.", + "xrefs" : [ "Wikipedia:Skin", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA:6530" + }, { + "val" : "EV:0100152" + }, { + "val" : "FMA:86166" + }, { + "val" : "GAID:933" + }, { + "val" : "MA:0000151" + }, { + "val" : "MAT:0000284" + }, { + "val" : "MESH:D012867" + }, { + "val" : "MIAA:0000284" + }, { + "val" : "SCTID:20795001" + }, { + "val" : "VHOG:0000860" + }, { + "val" : "Wikipedia:Skin" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000015", "lbl" : "non-material anatomical boundary", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures.", + "xrefs" : [ "CARO:0000010" ] + }, + "comments" : [ "Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms." ], + "xrefs" : [ { + "val" : "AEO:0000192" + }, { + "val" : "CARO:0000010" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:50705" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "lbl" : "endocrine pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin.", + "xrefs" : [ "GO:GO", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000650" + }, { + "val" : "CALOHA:TS-1302" + }, { + "val" : "EFO:0002542" + }, { + "val" : "EMAPA:35305" + }, { + "val" : "EV:0100129" + }, { + "val" : "FMA:16018" + }, { + "val" : "MA:0001582" + }, { + "val" : "NCIT:C32509" + }, { + "val" : "SCTID:361339003" + }, { + "val" : "TAO:0001260" + }, { + "val" : "VHOG:0000049" + }, { + "val" : "Wikipedia:Islets_of_Langerhans" + }, { + "val" : "ZFA:0001260" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "lbl" : "exocrine pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO].", + "xrefs" : [ "GOC:GO", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010407" + }, { + "val" : "BTO:0000434" + }, { + "val" : "CALOHA:TS-1241" + }, { + "val" : "EMAPA:35328" + }, { + "val" : "EV:0100093" + }, { + "val" : "FMA:16017" + }, { + "val" : "MA:0002415" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "NCIT:C32546" + }, { + "val" : "SCTID:248202004" + }, { + "val" : "TAO:0001249" + }, { + "val" : "VHOG:0000048" + }, { + "val" : "Wikipedia:Exocrine_component_of_pancreas" + }, { + "val" : "XAO:0000137" + }, { + "val" : "ZFA:0001249" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000018", "lbl" : "compound eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A light sensing organ composed of ommatidia.", + "xrefs" : [ "FB:gg", "Wikipedia:Compound_eye" ] + }, + "xrefs" : [ { + "val" : "BTO:0001921" + }, { + "val" : "HAO:0000217" + }, { + "val" : "TGMA:0000024" + }, { + "val" : "Wikipedia:Compound_eye" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000019", "lbl" : "camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid.", + "xrefs" : [ "GO:0043010", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010340" + }, { + "val" : "BIRNLEX:1169" + }, { + "val" : "BTO:0004688" + }, { + "val" : "EHDAA2:0000484" + }, { + "val" : "EHDAA:936" + }, { + "val" : "EMAPA:16198" + }, { + "val" : "FMA:54448" + }, { + "val" : "MA:0000261" + }, { + "val" : "NCIT:C12401" + }, { + "val" : "SCTID:181143004" + }, { + "val" : "TAO:0000107" + }, { + "val" : "VHOG:0000275" + }, { + "val" : "XAO:0000179" + }, { + "val" : "ZFA:0000107" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000020", "lbl" : "sense organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that is capable of transducing sensory stimulus to the nervous system.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/549", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0000094" + }, { + "val" : "BSA:0000121" + }, { + "val" : "BTO:0000202" + }, { + "val" : "CALOHA:TS-2043" + }, { + "val" : "EHDAA2:0001824" + }, { + "val" : "EHDAA:500" + }, { + "val" : "EMAPA:35955" + }, { + "val" : "GAID:63" + }, { + "val" : "HAO:0000930" + }, { + "val" : "MA:0000017" + }, { + "val" : "MESH:D012679" + }, { + "val" : "NCIT:C33224" + }, { + "val" : "SCTID:244485009" + }, { + "val" : "VHOG:0001407" + }, { + "val" : "WBbt:0006929" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000025", "lbl" : "tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "galen:Tube" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000026", "lbl" : "appendage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Major subdivision of an organism that protrudes from the body[DOS, CARO].", + "xrefs" : [ "CARO:DOS" ] + }, + "xrefs" : [ { + "val" : "AEO:0000193" + }, { + "val" : "BILA:0000018" + }, { + "val" : "BTO:0001492" + }, { + "val" : "CARO:0010003" + }, { + "val" : "EFO:0000799" + }, { + "val" : "EHDAA2:0003193" + }, { + "val" : "EV:0100155" + }, { + "val" : "HAO:0000144" + }, { + "val" : "MAT:0000023" + }, { + "val" : "MESH:D005121" + }, { + "val" : "MIAA:0000023" + }, { + "val" : "NCIT:C61460" + }, { + "val" : "VSAO:0000075" + }, { + "val" : "Wikipedia:Appendage" + }, { + "val" : "XAO:0000218" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000030", "lbl" : "lamina propria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions.", + "xrefs" : [ "Wikipedia:Lamina_propria" ] + }, + "xrefs" : [ { + "val" : "BTO:0002330" + }, { + "val" : "FMA:62517" + }, { + "val" : "NCIT:C32918" + }, { + "val" : "SCTID:298225002" + }, { + "val" : "Wikipedia:Lamina_propria" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000031", "lbl" : "lamina propria of trachea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a respiratory airway.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35877" + }, { + "val" : "FMA:265157" + }, { + "val" : "MA:0001858" + }, { + "val" : "NCIT:C49305" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000033", "lbl" : "head", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The head is the anterior-most division of the body [GO].", + "xrefs" : [ "GO:0060322", "Wikipedia:Head" ] + }, + "xrefs" : [ { + "val" : "AAO:0010335" + }, { + "val" : "AEO:0000106" + }, { + "val" : "BILA:0000115" + }, { + "val" : "BIRNLEX:1230" + }, { + "val" : "BTO:0000282" + }, { + "val" : "CALOHA:TS-0436" + }, { + "val" : "EFO:0000964" + }, { + "val" : "EHDAA2:0003106" + }, { + "val" : "EMAPA:31858" + }, { + "val" : "FMA:7154" + }, { + "val" : "GAID:61" + }, { + "val" : "HAO:0000397" + }, { + "val" : "MA:0000023" + }, { + "val" : "MAT:0000294" + }, { + "val" : "MESH:D006257" + }, { + "val" : "MIAA:0000294" + }, { + "val" : "NCIT:C12419" + }, { + "val" : "SCTID:302548004" + }, { + "val" : "SPD:0000016" + }, { + "val" : "TAO:0001114" + }, { + "val" : "TGMA:0000002" + }, { + "val" : "VHOG:0001644" + }, { + "val" : "WBbt:0005739" + }, { + "val" : "Wikipedia:Head" + }, { + "val" : "XAO:0003024" + }, { + "val" : "ZFA:0001114" + }, { + "val" : "galen:Head" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000042", "lbl" : "serous membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer.", + "xrefs" : [ "Wikipedia:Serous_membrane", "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "FMA:9581" + }, { + "val" : "GAID:19" + }, { + "val" : "MESH:D012704" + }, { + "val" : "NCIT:C13169" + }, { + "val" : "SCTID:362878009" + }, { + "val" : "TAO:0005425" + }, { + "val" : "Wikipedia:Serous_membrane" + }, { + "val" : "ZFA:0005425" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000043", "lbl" : "tendon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dense regular connective tissue that connects muscle to bone[VSAO].", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000073", "Wikipedia:Tendon", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AEO:0000091" + }, { + "val" : "BTO:0001356" + }, { + "val" : "CALOHA:TS-1021" + }, { + "val" : "EHDAA2:0003091" + }, { + "val" : "EMAPA:35854" + }, { + "val" : "EV:0100149" + }, { + "val" : "FMA:9721" + }, { + "val" : "GAID:276" + }, { + "val" : "MA:0000115" + }, { + "val" : "MESH:D013710" + }, { + "val" : "NCIT:C13045" + }, { + "val" : "SCTID:256667004" + }, { + "val" : "VHOG:0001286" + }, { + "val" : "VSAO:0000073" + }, { + "val" : "Wikipedia:Tendon" + }, { + "val" : "XAO:0000173" + }, { + "val" : "ZFA:0005647" + }, { + "val" : "galen:Tendon" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000045", "lbl" : "ganglion", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A biological tissue mass, most commonly a mass of nerve cell bodies.", + "xrefs" : [ "Wikipedia:Ganglion", "https://github.com/obophenotype/uberon/issues/300" ] + }, + "xrefs" : [ { + "val" : "AAO:0010426" + }, { + "val" : "AEO:0000135" + }, { + "val" : "BAMS:G" + }, { + "val" : "BTO:0000497" + }, { + "val" : "CALOHA:TS-0397" + }, { + "val" : "EFO:0000899" + }, { + "val" : "EHDAA2:0003135" + }, { + "val" : "EHDAA:2897" + }, { + "val" : "EHDAA:4662" + }, { + "val" : "EHDAA:5621" + }, { + "val" : "EHDAA:918" + }, { + "val" : "EMAPA:32846" + }, { + "val" : "EV:0100372" + }, { + "val" : "FMA:5884" + }, { + "val" : "MA:0002406" + }, { + "val" : "MAT:0000207" + }, { + "val" : "MAT:0000343" + }, { + "val" : "MESH:D005724" + }, { + "val" : "MIAA:0000207" + }, { + "val" : "MIAA:0000343" + }, { + "val" : "NCIT:C12719" + }, { + "val" : "NLXANAT:100302" + }, { + "val" : "TAO:0000190" + }, { + "val" : "TGMA:0001016" + }, { + "val" : "VHOG:0000156" + }, { + "val" : "WBbt:0005189" + }, { + "val" : "Wikipedia:Ganglion" + }, { + "val" : "XAO:0000209" + }, { + "val" : "ZFA:0000190" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000047", "lbl" : "simple eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity.", + "xrefs" : [ "Wikipedia:Eye#Simple_eyes" ] + }, + "xrefs" : [ { + "val" : "TGMA:0000729" + }, { + "val" : "Wikipedia:Eye#Simple_eyes" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000055", "lbl" : "vessel", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A tubular structure that contains, conveys body fluid, such as blood or lymph.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000058", "lbl" : "duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tubular structure that transports secreted or excreted substances.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm#ducts" ] + }, + "xrefs" : [ { + "val" : "AAO:0011123" + }, { + "val" : "FMA:30320" + }, { + "val" : "NCIT:C12948" + }, { + "val" : "SCTID:91726008" + }, { + "val" : "TAO:0005171" + }, { + "val" : "Wikipedia:Duct_(anatomy)" + }, { + "val" : "XAO:0004000" + }, { + "val" : "ZFA:0005171" + }, { + "val" : "galen:Duct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "lbl" : "large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong].", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Large_intestine_(anatomy)" ] + }, + "xrefs" : [ { + "val" : "AAO:0010396" + }, { + "val" : "BTO:0000706" + }, { + "val" : "CALOHA:TS-1306" + }, { + "val" : "EFO:0000840" + }, { + "val" : "EMAPA:19252" + }, { + "val" : "EV:0100077" + }, { + "val" : "FMA:7201" + }, { + "val" : "GAID:306" + }, { + "val" : "MA:0000333" + }, { + "val" : "MESH:D007420" + }, { + "val" : "MIAA:0000046" + }, { + "val" : "NCIT:C12379" + }, { + "val" : "SCTID:181254001" + }, { + "val" : "VHOG:0000054" + }, { + "val" : "Wikipedia:Large_intestine_(anatomy)" + }, { + "val" : "XAO:0000131" + }, { + "val" : "galen:LargeIntestine" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000060", "lbl" : "anatomical wall", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers.", + "xrefs" : [ "FMA:82482" ] + }, + "xrefs" : [ { + "val" : "FMA:82482" + }, { + "val" : "galen:Wall" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000061", "lbl" : "anatomical structure", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.", + "xrefs" : [ "CARO:0000003" ] + }, + "xrefs" : [ { + "val" : "AAO:0010825" + }, { + "val" : "AEO:0000003" + }, { + "val" : "BILA:0000003" + }, { + "val" : "CARO:0000003" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "EHDAA2:0003003" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "EMAPA:0" + }, { + "val" : "FMA:305751" + }, { + "val" : "FMA:67135" + }, { + "val" : "GAID:781" + }, { + "val" : "HAO:0000003" + }, { + "val" : "MA:0003000" + }, { + "val" : "MESH:D000825" + }, { + "val" : "SCTID:362889002" + }, { + "val" : "TAO:0000037" + }, { + "val" : "TGMA:0001823" + }, { + "val" : "VHOG:0001759" + }, { + "val" : "XAO:0003000" + }, { + "val" : "ZFA:0000037" + }, { + "val" : "http://dbpedia.org/ontology/AnatomicalStructure" } ] } }, { @@ -16285,35 +46167,68 @@ "lbl" : "organ", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Anatomical structure that performs a specific function or group of functions [WP].", + "xrefs" : [ "Wikipedia:Organ_(anatomy)" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:4" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "CARO:0020004" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "EFO:0000634" + }, { + "val" : "EMAPA:35949" + }, { + "val" : "ENVO:01000162" + }, { + "val" : "FMA:67498" + }, { + "val" : "MA:0003001" + }, { + "val" : "NCIT:C13018" + }, { + "val" : "SCTID:272625005" + }, { + "val" : "WBbt:0003760" + }, { + "val" : "Wikipedia:Organ_(anatomy)" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000063", "lbl" : "organ subunit", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:86140" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000064", "lbl" : "organ part", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "A multicellular structure that is a part of an organ.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011124" + }, { + "val" : "BIRNLEX:16" + }, { + "val" : "EFO:0000635" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:82472" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "SCTID:113343008" + }, { + "val" : "SCTID:91717005" } ] } }, { @@ -16321,119 +46236,457 @@ "lbl" : "respiratory tract", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001606" + }, { + "val" : "EHDAA:1568" + }, { + "val" : "EHDAA:2219" + }, { + "val" : "EMAPA:16737" + }, { + "val" : "FMA:265130" + }, { + "val" : "SCTID:361110005" + }, { + "val" : "VHOG:0000393" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000066", "lbl" : "fully formed stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001043" + }, { + "val" : "BilaDO:0000004" + }, { + "val" : "EFO:0001272" + }, { + "val" : "FBdv:00005369" + }, { + "val" : "WBls:0000041" + }, { + "val" : "XtroDO:0000084" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000068", "lbl" : "embryo stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A life cycle stage that starts with fertilization and ends with the fully formed embryo.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BilaDO:0000002" + }, { + "val" : "EV:0300001" + }, { + "val" : "FBdv:00005289" + }, { + "val" : "FMA:72652" + }, { + "val" : "HsapDv:0000002" + }, { + "val" : "MmusDv:0000002" + }, { + "val" : "OGES:000000" + }, { + "val" : "OGES:000022" + }, { + "val" : "SCTID:296280003" + }, { + "val" : "WBls:0000003" + }, { + "val" : "WBls:0000092" + }, { + "val" : "WBls:0000102" + }, { + "val" : "XAO:1000012" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000071", "lbl" : "death stage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "definition" : { + "val" : "End of the life of an organism.", + "xrefs" : [ "XAO:0000437" ] + }, + "xrefs" : [ { + "val" : "XAO:0000437" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "XtroDO:0000085" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000072", "lbl" : "proximo-distal subdivision of respiratory tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An section of a respiratory tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:45660" + }, { + "val" : "MA:0000434" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000073", "lbl" : "regional part of nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS.", + "xrefs" : [ "BIRNLEX:1157" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1157" + }, { + "val" : "NCIT:C13040" + }, { + "val" : "SCTID:25087005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000075", "lbl" : "subdivision of skeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.", + "xrefs" : [ "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:85544" + }, { + "val" : "NCIT:C34076" + }, { + "val" : "SCTID:118966000" + }, { + "val" : "galen:ComplexSkeletalStructure" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000076", "lbl" : "external ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm.", + "xrefs" : [ "MGI:anna", "MP:0012532" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001968" + }, { + "val" : "EHDAA:1494" + }, { + "val" : "EHDAA:350" + }, { + "val" : "EHDAA:4784" + }, { + "val" : "EHDAA:4790" + }, { + "val" : "EHDAA:4796" + }, { + "val" : "EHDAA:7860" + }, { + "val" : "EMAPA:16096" + }, { + "val" : "FMA:87656" + }, { + "val" : "NCIT:C34309" + }, { + "val" : "Wikipedia:External_ectoderm" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000077", "lbl" : "mixed endoderm/mesoderm-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops from the endoderm and the mesoderm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000078", "lbl" : "mixed ectoderm/mesoderm/endoderm-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops from the ectoderm, mesoderm and endoderm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000085", "lbl" : "morula", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum.", + "xrefs" : [ "MP:0012130" ] + }, + "xrefs" : [ { + "val" : "BTO:0001508" + }, { + "val" : "EHDAA2:0000005" + }, { + "val" : "FMA:292334" + }, { + "val" : "GAID:1295" + }, { + "val" : "MESH:D009028" + }, { + "val" : "NCIT:C34212" + }, { + "val" : "SCTID:361474003" + }, { + "val" : "Wikipedia:Morula" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000086", "lbl" : "zona pellucida", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes.", + "xrefs" : [ "Wikipedia:Zona_pellucida" ] + }, + "xrefs" : [ { + "val" : "BTO:0003135" + }, { + "val" : "EHDAA2:0002220" + }, { + "val" : "EHDAA:31" + }, { + "val" : "EHDAA:62" + }, { + "val" : "EMAPA:16035" + }, { + "val" : "FMA:18674" + }, { + "val" : "GAID:410" + }, { + "val" : "MA:0001715" + }, { + "val" : "MESH:D015044" + }, { + "val" : "NCIT:C33896" + }, { + "val" : "TAO:0001111" + }, { + "val" : "Wikipedia:Zona_pellucida" + }, { + "val" : "ZFA:0001111" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000087", "lbl" : "inner cell mass", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mass of cells that develop into the body of the embryo and some extraembryonic tissues.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:pvb" ] + }, + "xrefs" : [ { + "val" : "EFO:0000547" + }, { + "val" : "EHDAA2:0000830" + }, { + "val" : "EHDAA:40" + }, { + "val" : "EMAPA:16041" + }, { + "val" : "FMA:86557" + }, { + "val" : "NCIT:C13740" + }, { + "val" : "SCTID:361456007" + }, { + "val" : "VHOG:0000742" + }, { + "val" : "Wikipedia:Inner_cell_mass" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000088", "lbl" : "trophoblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0005031" ] + }, + "comments" : [ "Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast]" ], + "xrefs" : [ { + "val" : "BTO:0001079" + }, { + "val" : "CALOHA:TS-1070" + }, { + "val" : "EV:0100120" + }, { + "val" : "FMA:83029" + }, { + "val" : "GAID:1152" + }, { + "val" : "MESH:D014327" + }, { + "val" : "NCIT:C93292" + }, { + "val" : "SCTID:362839005" + }, { + "val" : "Wikipedia:Trophoblast" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000091", "lbl" : "bilaminar disc", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc.", + "xrefs" : [ "MP:0003886" ] + }, + "xrefs" : [ { + "val" : "FMA:293863" + }, { + "val" : "NCIT:C34112" + }, { + "val" : "Wikipedia:Bilaminar_disc" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000092", "lbl" : "post-embryonic stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Stage succeeding embryo, including mature structure.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BilaDO:0000003" + }, { + "val" : "OGES:000010" + }, { + "val" : "OGES:000014" + }, { + "val" : "OGES:000024" + }, { + "val" : "WBls:0000022" + }, { + "val" : "WBls:0000093" + }, { + "val" : "WBls:0000103" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000094", "lbl" : "membrane organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA].", + "xrefs" : [ "FMA:7145" ] + }, + "xrefs" : [ { + "val" : "FMA:7145" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000095", "lbl" : "cardiac neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia].", + "xrefs" : [ "Wikipedia:Cardiac_neural_crest" ] + }, + "xrefs" : [ { + "val" : "TAO:0002173" + }, { + "val" : "Wikipedia:Cardiac_neural_crest" + }, { + "val" : "XAO:0004190" + }, { + "val" : "ZFA:0001648" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000101", "lbl" : "lobe of lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lung lobe is one of the rounded projections that compose the lung[GO].", + "xrefs" : [ "GOC:GO" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36281" + }, { + "val" : "FMA:7311" + }, { + "val" : "MA:0003098" + }, { + "val" : "NCIT:C34021" + }, { + "val" : "SCTID:245524004" + }, { + "val" : "galen:LobeOfLung" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000102", "lbl" : "lung vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO].", + "xrefs" : [ "GOC:GO" ] + }, + "xrefs" : [ { + "val" : "FMA:73750" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000104", "lbl" : "life cycle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FBdv:00000000" + }, { + "val" : "HsapDv:0000001" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "MmusDv:0000001" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "OGES:000011" + }, { + "val" : "ncithesaurus:Life" } ] } }, { @@ -16441,3108 +46694,19551 @@ "lbl" : "life cycle stage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "A spatiotemporal region encompassing some part of the life cycle of an organism.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BILS:0000105" + }, { + "val" : "EFO:0000399" + }, { + "val" : "FBdv:00007012" + }, { + "val" : "FMA:24120" + }, { + "val" : "HsapDv:0000000" + }, { + "val" : "MESH:D008018" + }, { + "val" : "MmusDv:0000000" + }, { + "val" : "OlatDv:0000010" + }, { + "val" : "PdumDv:0000090" + }, { + "val" : "WBls:0000002" + }, { + "val" : "XAO:1000000" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "ZFS:0000000" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "ZFS:0100000" + }, { + "val" : "ncithesaurus:Developmental_Stage" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000106", "lbl" : "zygote stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stage at which the organism is a single cell produced by means of sexual reproduction.", + "xrefs" : [ "Wikipedia:Zygote" ] + }, + "xrefs" : [ { + "val" : "BILS:0000106" + }, { + "val" : "BilaDO:0000005" + }, { + "val" : "EFO:0001322" + }, { + "val" : "EHDAA:27" + }, { + "val" : "FBdv:00005288" + }, { + "val" : "NCIT:C12601" + }, { + "val" : "PdumDv:0000100" + }, { + "val" : "VHOG:0000745" + }, { + "val" : "Wikipedia:Zygote" + }, { + "val" : "XAO:1000001" + }, { + "val" : "ZFS:0000001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000107", "lbl" : "cleavage stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.", + "xrefs" : [ "GO:0040016", "Wikipedia:Cleavage_(embryo)" ] + }, + "xrefs" : [ { + "val" : "BILS:0000107" + }, { + "val" : "BilaDO:0000006" + }, { + "val" : "EFO:0001290" + }, { + "val" : "FBdv:00000054" + }, { + "val" : "MESH:D002970" + }, { + "val" : "MmusDv:0000004" + }, { + "val" : "OGES:000015" + }, { + "val" : "OGES:000020" + }, { + "val" : "PdumDv:0000200" + }, { + "val" : "Wikipedia:Cleavage_(embryo)" + }, { + "val" : "XAO:1000004" + }, { + "val" : "ZFS:0000046" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000108", "lbl" : "blastula stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.", + "xrefs" : [ "Wikipedia:Blastula" ] + }, + "xrefs" : [ { + "val" : "BILS:0000108" + }, { + "val" : "BilaDO:0000007" + }, { + "val" : "EFO:0001282" + }, { + "val" : "HsapDv:0000006" + }, { + "val" : "MmusDv:0000007" + }, { + "val" : "OGES:000003" + }, { + "val" : "OGES:000016" + }, { + "val" : "OGES:000021" + }, { + "val" : "WBls:0000005" + }, { + "val" : "Wikipedia:Blastula" + }, { + "val" : "XAO:1000003" + }, { + "val" : "ZFS:0000045" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000109", "lbl" : "gastrula stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.", + "xrefs" : [ "GO:0007369" ] + }, + "xrefs" : [ { + "val" : "BILS:0000109" + }, { + "val" : "BilaDO:0000008" + }, { + "val" : "EFO:0001296" + }, { + "val" : "FBdv:00005317" + }, { + "val" : "HsapDv:0000010" + }, { + "val" : "MmusDv:0000013" + }, { + "val" : "OGES:000004" + }, { + "val" : "OGES:000019" + }, { + "val" : "WBls:0000010" + }, { + "val" : "XAO:1000005" + }, { + "val" : "ZFS:0000047" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000110", "lbl" : "neurula stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.", + "xrefs" : [ "GO:0001841" ] + }, + "xrefs" : [ { + "val" : "BILS:0000110" + }, { + "val" : "BilaDO:0000009" + }, { + "val" : "HsapDv:0000012" + }, { + "val" : "MmusDv:0000017" + }, { + "val" : "XAO:1000006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000111", "lbl" : "organogenesis stage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.", + "xrefs" : [ "Wikipedia:Organogenesis" ] + }, + "xrefs" : [ { + "val" : "BILS:0000111" + }, { + "val" : "BilaDO:0000010" + }, { + "val" : "HsapDv:0000015" + }, { + "val" : "MmusDv:0000018" + }, { + "val" : "OGES:000005" + }, { + "val" : "OGES:000032" + }, { + "val" : "Wikipedia:Organogenesis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000114", "lbl" : "lung connective tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:anna", "MP:0002276", "PMID:14635660" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35521" + }, { + "val" : "FMA:27533" + }, { + "val" : "MA:0001782" + }, { + "val" : "SCTID:201609008" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000115", "lbl" : "lung epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial layer of the lung.", + "xrefs" : [ "MP:0006382" ] + }, + "xrefs" : [ { + "val" : "BTO:0001653" + }, { + "val" : "EMAPA:32860" + }, { + "val" : "MA:0001783" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000117", "lbl" : "respiratory tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea.", + "xrefs" : [ "GO:0030323", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:12224" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0000118", "lbl" : "lung bud", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000122", - "lbl" : "neuron projection bundle", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000125", - "lbl" : "neural nucleus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000126", - "lbl" : "cranial nerve nucleus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000153", - "lbl" : "anterior region of body", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000154", - "lbl" : "posterior region of body", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000158", - "lbl" : "membranous layer", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000161", - "lbl" : "orifice", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000165", - "lbl" : "mouth", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000166", - "lbl" : "oral opening", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000167", - "lbl" : "oral cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000170", - "lbl" : "pair of lungs", - "type" : "CLASS", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000171", - "lbl" : "respiration organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000178", - "lbl" : "blood", - "type" : "CLASS", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000179", - "lbl" : "haemolymphatic fluid", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000304", - "lbl" : "tendon sheath", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000307", - "lbl" : "blastula", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000325", - "lbl" : "gastric gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000328", - "lbl" : "gut wall", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000332", - "lbl" : "yellow bone marrow", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000344", - "lbl" : "mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000353", - "lbl" : "parenchyma", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000355", - "lbl" : "pharyngeal mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000358", - "lbl" : "blastocyst", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000361", - "lbl" : "red bone marrow", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000371", - "lbl" : "syncytiotrophoblast", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000377", - "lbl" : "maxillary nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Structure derived from foregut that becomes a lung[GO].", + "xrefs" : [ "GO:0060431", "Wikipedia:Respiratory_bud" ] + }, + "xrefs" : [ { + "val" : "BTO:0001643" + }, { + "val" : "EHDAA2:0004089" + }, { + "val" : "NCIT:C34260" + }, { + "val" : "NCIT:C34282" + }, { + "val" : "SCTID:361427007" + }, { + "val" : "Wikipedia:Respiratory_bud" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000379", - "lbl" : "tracheal mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000383", - "lbl" : "musculature of body", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000122", + "lbl" : "neuron projection bundle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.", + "xrefs" : [ "CARO:0001001", "FBC:DOS", "FBbt:00005099" ] + }, + "xrefs" : [ { + "val" : "CARO:0001001" + }, { + "val" : "NLX:147821" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000389", - "lbl" : "lens cortex", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000125", + "lbl" : "neural nucleus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO).", + "xrefs" : [ "NLX:28443" ] + }, + "xrefs" : [ { + "val" : "AEO:0000136" + }, { + "val" : "FMA:83686" + }, { + "val" : "NCIT:C13197" + }, { + "val" : "NLX:28443" + }, { + "val" : "Wikipedia:Nucleus_(neuroanatomy)" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000390", - "lbl" : "lens nucleus", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000126", + "lbl" : "cranial nerve nucleus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves.", + "xrefs" : [ "NLX:28532" ] + }, + "xrefs" : [ { + "val" : "FMA:54501" + }, { + "val" : "NLX:28532" + }, { + "val" : "SCTID:280160003" + }, { + "val" : "Wikipedia:Cranial_nerve_nucleus" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000409", - "lbl" : "serous gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000410", - "lbl" : "bronchial mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000415", - "lbl" : "artery wall", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000153", + "lbl" : "anterior region of body", "type" : "CLASS" }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000456", - "lbl" : "secretion of exocrine gland", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000154", + "lbl" : "posterior region of body", "type" : "CLASS" }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000463", - "lbl" : "organism substance", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000158", + "lbl" : "membranous layer", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "xrefs" : [ { + "val" : "FMA:30322" + }, { + "val" : "FMA:82500" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "MESH:D008566" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "NCIT:C12749" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000464", - "lbl" : "anatomical space", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "lbl" : "anal canal", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus.", + "xrefs" : [ "Wikipedia:Anal_canal" ] + }, + "xrefs" : [ { + "val" : "BTO:0001978" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "CALOHA:TS-2160" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000465", - "lbl" : "material anatomical entity", - "type" : "CLASS", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "val" : "EMAPA:18256" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:15703" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000466", - "lbl" : "immaterial anatomical entity", - "type" : "CLASS", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "val" : "MA:0000330" + }, { + "val" : "NCIT:C12375" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "SCTID:245438008" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "Wikipedia:Anal_canal" + }, { + "val" : "galen:AnalCanal" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000467", - "lbl" : "anatomical system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000160", + "lbl" : "intestine", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine.", + "xrefs" : [ "GOC:GO", "Wikipedia:Intestine" ] + }, + "xrefs" : [ { + "val" : "AAO:0000246" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "ANISEED:1235303" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "BSA:0000093" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000468", - "lbl" : "multicellular organism", - "type" : "CLASS", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "val" : "BTO:0000648" + }, { + "val" : "CALOHA:TS-0490" + }, { + "val" : "EFO:0000834" + }, { + "val" : "EMAPA:32874" + }, { + "val" : "EV:0100071" + }, { + "val" : "FMA:7199" + }, { + "val" : "GAID:295" + }, { + "val" : "MA:0000328" + }, { + "val" : "MA:0001524" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "MESH:D007422" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "MIAA:0000043" + }, { + "val" : "NCIT:C12736" + }, { + "val" : "SCTID:256876008" + }, { + "val" : "TAO:0001338" + }, { + "val" : "VHOG:0000056" + }, { + "val" : "WBbt:0005772" + }, { + "val" : "Wikipedia:Intestine" + }, { + "val" : "XAO:0000129" + }, { + "val" : "ZFA:0001338" + }, { + "val" : "galen:Intestine" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000474", - "lbl" : "female reproductive system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000161", + "lbl" : "orifice", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified].", + "xrefs" : [ "FMA:3724" ] + }, + "xrefs" : [ { + "val" : "FMA:3724" + }, { + "val" : "SCTID:91837002" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000475", - "lbl" : "organism subdivision", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000162", + "lbl" : "cloaca", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Cloaca" ] + }, + "xrefs" : [ { + "val" : "AAO:0000095" + }, { + "val" : "GAID:1206" + }, { + "val" : "MESH:D002988" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "NCIT:C34127" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "SCTID:362857006" + }, { + "val" : "SCTID:370631000" + }, { + "val" : "VHOG:0001186" + }, { + "val" : "Wikipedia:Cloaca" + }, { + "val" : "XAO:0000244" + }, { + "val" : "ZFA:0005781" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000476", - "lbl" : "acellular anatomical structure", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "lbl" : "embryonic cloaca", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP].", + "xrefs" : [ "MP:0010115", "Wikipedia:Cloaca_(embryology)" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000256" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "EHDAA:4895" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "EMAPA:27573" + }, { + "val" : "Wikipedia:Cloaca_(embryology)" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000477", - "lbl" : "anatomical cluster", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000165", + "lbl" : "mouth", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks).", + "xrefs" : [ "Wikipedia:Mouth", "https://github.com/obophenotype/uberon/wiki/The-digestive-tract" ] + }, + "xrefs" : [ { + "val" : "AAO:0010355" + }, { + "val" : "BTO:0001090" + }, { + "val" : "BTO:0004698" + }, { + "val" : "CALOHA:TS-1315" + }, { + "val" : "EFO:0000825" + }, { + "val" : "EHDAA2:0001326" + }, { + "val" : "EHDAA:542" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "EMAPA:16262" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "FMA:49184" + }, { + "val" : "GAID:75" + }, { + "val" : "MA:0000341" + }, { + "val" : "MA:0002474" + }, { + "val" : "MAT:0000038" + }, { + "val" : "MESH:D009055" + }, { + "val" : "MIAA:0000038" + }, { + "val" : "SCTID:21082005" + }, { + "val" : "TADS:0000040" + }, { + "val" : "TAO:0000547" + }, { + "val" : "TAO:0000590" + }, { + "val" : "TGMA:0000131" + }, { + "val" : "VHOG:0000280" + }, { + "val" : "VHOG:0000812" + }, { + "val" : "Wikipedia:Mouth" + }, { + "val" : "XAO:0003029" + }, { + "val" : "ZFA:0000547" + }, { + "val" : "ZFA:0000590" + }, { + "val" : "galen:Mouth" + }, { + "val" : "http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000478", - "lbl" : "extraembryonic structure", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000479", - "lbl" : "tissue", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000166", + "lbl" : "oral opening", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "The orifice that connects the mouth to the exterior of the body.", + "xrefs" : [ "https://github.com/obophenotype/uberon/wiki/The-digestive-tract" ] + }, + "xrefs" : [ { + "val" : "FMA:59806" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000481", - "lbl" : "multi-tissue structure", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000167", + "lbl" : "oral cavity", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present).", + "xrefs" : [ "ISBN:0073040584", "https://github.com/obophenotype/uberon/wiki/The-digestive-tract", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000053" + }, { + "val" : "AAO:0000960" + }, { + "val" : "BSA:0000107" + }, { + "val" : "CALOHA:TS-1315" + }, { + "val" : "EFO:0001975" + }, { + "val" : "EHDAA2:0001324" + }, { + "val" : "EHDAA:6970" + }, { + "val" : "EMAPA:17411" + }, { + "val" : "EMAPA:18399" + }, { + "val" : "EV:0100057" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:20292" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "HAO:0000669" + }, { + "val" : "NCIT:C12421" + }, { + "val" : "SCTID:181220002" + }, { + "val" : "TAO:0001027" + }, { + "val" : "TGMA:0000102" + }, { + "val" : "VHOG:0000188" + }, { + "val" : "WBbt:0005255" + }, { + "val" : "XAO:0000126" + }, { + "val" : "ZFA:0001027" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000483", - "lbl" : "epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000484", - "lbl" : "simple cuboidal epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000485", - "lbl" : "simple columnar epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000486", - "lbl" : "multilaminar epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000487", - "lbl" : "simple squamous epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000488", - "lbl" : "atypical epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000489", - "lbl" : "cavitated compound organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000490", - "lbl" : "unilaminar epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000915", - "lbl" : "thoracic segment of trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000916", - "lbl" : "abdomen", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000922", - "lbl" : "embryo", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000923", - "lbl" : "germ layer", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000924", - "lbl" : "ectoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000925", - "lbl" : "endoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000926", - "lbl" : "mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000930", - "lbl" : "stomodeum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000945", - "lbl" : "stomach", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000168", + "lbl" : "proximal-distal subdivision of colon", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A section dividing a colon along a proximal-distal axis.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:222905" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000947", - "lbl" : "aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000170", + "lbl" : "pair of lungs", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The pair of anatomical structures comprised of a left lung and right lung.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:68877" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000948", - "lbl" : "heart", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000171", + "lbl" : "respiration organ", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.", + "xrefs" : [ "GO:0007585" ] + }, + "xrefs" : [ { + "val" : "SCTID:272626006" + }, { + "val" : "SPD:0000428" + }, { + "val" : "TGMA:0001247" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000949", - "lbl" : "endocrine system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000955", - "lbl" : "brain", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000174", + "lbl" : "excreta", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity.", + "xrefs" : [ "GO:0007588", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0000184" + }, { + "val" : "BTO:0000491" + }, { + "val" : "EHDAA2_RETIRED:0003184" + }, { + "val" : "ENVO:02000022" + }, { + "val" : "FMA:9674" + }, { + "val" : "galen:Excretion" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000957", - "lbl" : "lamina", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000962", - "lbl" : "nerve of cervical vertebra", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000178", + "lbl" : "blood", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A fluid that is composed of blood plasma and erythrocytes.", + "xrefs" : [ "FMA:9670", "Wikipedia:Blood", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/9" ] + }, + "xrefs" : [ { + "val" : "AAO:0000046" + }, { + "val" : "BTO:0000089" + }, { + "val" : "CALOHA:TS-0079" + }, { + "val" : "EFO:0000296" + }, { + "val" : "EHDAA2:0000176" + }, { + "val" : "EHDAA:418" + }, { + "val" : "EMAPA:16332" + }, { + "val" : "ENVO:02000027" + }, { + "val" : "EV:0100047" + }, { + "val" : "FMA:9670" + }, { + "val" : "GAID:965" + }, { + "val" : "MA:0000059" + }, { + "val" : "MESH:D001769" + }, { + "val" : "MIAA:0000315" + }, { + "val" : "NCIT:C12434" + }, { + "val" : "TAO:0000007" + }, { + "val" : "VHOG:0000224" + }, { + "val" : "Wikipedia:Blood" + }, { + "val" : "XAO:0000124" + }, { + "val" : "ZFA:0000007" + }, { + "val" : "galen:Blood" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000963", - "lbl" : "head sensillum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000964", - "lbl" : "cornea", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000179", + "lbl" : "haemolymphatic fluid", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "CARO:0000081" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000965", - "lbl" : "lens of camera-type eye", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "lbl" : "tetrapod frontal bone", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The bone forming the forehead and roof of the eye orbit.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0000107", "PMID:7914451", "Wikipedia:Frontal_bone" ] + }, + "xrefs" : [ { + "val" : "AAO:0000206" + }, { + "val" : "EMAPA:19016" + }, { + "val" : "FMA:52734" + }, { + "val" : "GAID:226" + }, { + "val" : "MA:0001466" + }, { + "val" : "MESH:D005624" + }, { + "val" : "NCIT:C32635" + }, { + "val" : "SCTID:181793006" + }, { + "val" : "VSAO:0000208" + }, { + "val" : "Wikipedia:Frontal_bone" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000966", - "lbl" : "retina", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "lbl" : "atlanto-occipital joint", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital.", + "xrefs" : [ "Wikipedia:Atlanto-occipital_joint" ] + }, + "xrefs" : [ { + "val" : "FMA:24939" + }, { + "val" : "NCIT:C32158" + }, { + "val" : "SCTID:361831006" + }, { + "val" : "Wikipedia:Atlanto-occipital_joint" + }, { + "val" : "ncithesaurus:Atlanto-occipital_Joint-Atlanto" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000970", - "lbl" : "eye", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000304", + "lbl" : "tendon sheath", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath.", + "xrefs" : [ "Wikipedia:Tendon_sheath" ] + }, + "xrefs" : [ { + "val" : "BTO:0000051" + }, { + "val" : "FMA:45087" + }, { + "val" : "FMA:76715" + }, { + "val" : "NCIT:C96299" + }, { + "val" : "SCTID:361885006" + }, { + "val" : "Wikipedia:Tendon_sheath" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000971", - "lbl" : "ommatidium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000974", - "lbl" : "neck", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000977", - "lbl" : "pleura", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000982", - "lbl" : "skeletal joint", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000988", - "lbl" : "pons", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000307", + "lbl" : "blastula", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.", + "xrefs" : [ "Wikipedia:Blastula" ] + }, + "xrefs" : [ { + "val" : "BILA:0000059" + }, { + "val" : "BTO:0000128" + }, { + "val" : "GAID:1294" + }, { + "val" : "MESH:D036703" + }, { + "val" : "OGEM:000006" + }, { + "val" : "Wikipedia:Blastula" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000990", - "lbl" : "reproductive system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000317", + "lbl" : "colonic mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000271" + }, { + "val" : "CALOHA:TS-0164" + }, { + "val" : "EFO:0003038" + }, { + "val" : "EMAPA:27375" + }, { + "val" : "FMA:14984" + }, { + "val" : "FMA:85388" + }, { + "val" : "MA:0003194" + }, { + "val" : "SCTID:362157008" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000991", - "lbl" : "gonad", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0000992", - "lbl" : "ovary", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000320", + "lbl" : "duodenal mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mucosa that is part of a duodenum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000367" + }, { + "val" : "CALOHA:TS-0213" + }, { + "val" : "EMAPA:27235" + }, { + "val" : "FMA:14942" + }, { + "val" : "MA:0003207" + }, { + "val" : "SCTID:362146003" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001003", - "lbl" : "skin epidermis", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000325", + "lbl" : "gastric gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin.", + "xrefs" : [ "MGI:anna" ] + }, + "xrefs" : [ { + "val" : "BTO:0000503" + }, { + "val" : "EMAPA:27181" + }, { + "val" : "FMA:14919" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001004", - "lbl" : "respiratory system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000326", + "lbl" : "pancreatic juice", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.", + "xrefs" : [ "GO:0030157" ] + }, + "xrefs" : [ { + "val" : "BTO:0000504" + }, { + "val" : "CALOHA:TS-2235" + }, { + "val" : "FMA:62973" + }, { + "val" : "GAID:1166" + }, { + "val" : "MESH:D010189" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001005", - "lbl" : "respiratory airway", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001007", - "lbl" : "digestive system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000328", + "lbl" : "gut wall", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000547" + }, { + "val" : "FMA:45653" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001009", - "lbl" : "circulatory system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000332", + "lbl" : "yellow bone marrow", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Bone marrow in which the fat cells predominate in the meshes of the reticular network.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/Yellow+Marrow" ] + }, + "xrefs" : [ { + "val" : "BTO:0000635" + }, { + "val" : "FMA:74596" + }, { + "val" : "SCTID:328639002" + }, { + "val" : "SCTID:5023006" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001013", - "lbl" : "adipose tissue", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000333", + "lbl" : "intestinal gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm].", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000640" + }, { + "val" : "FMA:15052" + }, { + "val" : "SCTID:266297002" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001015", - "lbl" : "musculature", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001016", - "lbl" : "nervous system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000344", + "lbl" : "mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP].", + "xrefs" : [ "Wikipedia:Mucous_membrane" ] + }, + "xrefs" : [ { + "val" : "AEO:0000199" + }, { + "val" : "BTO:0000886" + }, { + "val" : "CALOHA:TS-2031" + }, { + "val" : "EHDAA2_RETIRED:0003234" + }, { + "val" : "EV:0100382" + }, { + "val" : "FMA:85355" + }, { + "val" : "FMA:85358" + }, { + "val" : "GAID:297" + }, { + "val" : "MESH:D009092" + }, { + "val" : "NCIT:C13166" + }, { + "val" : "SCTID:361693009" + }, { + "val" : "Wikipedia:Mucous_membrane" + }, { + "val" : "galen:Mucosa" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001017", - "lbl" : "central nervous system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000353", + "lbl" : "parenchyma", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues.", + "xrefs" : [ "Wikipedia:Parenchyma" ] + }, + "xrefs" : [ { + "val" : "EHDAA:3015" + }, { + "val" : "EHDAA:3905" + }, { + "val" : "EHDAA:3999" + }, { + "val" : "EHDAA:4005" + }, { + "val" : "EHDAA:6899" + }, { + "val" : "EHDAA:6903" + }, { + "val" : "EHDAA:6994" + }, { + "val" : "EHDAA:8086" + }, { + "val" : "EHDAA:9182" + }, { + "val" : "EHDAA:9190" + }, { + "val" : "EHDAA:9196" + }, { + "val" : "EHDAA:9202" + }, { + "val" : "FMA:45732" + }, { + "val" : "NCIT:C74601" + }, { + "val" : "Wikipedia:Parenchyma" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001021", - "lbl" : "nerve", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000355", + "lbl" : "pharyngeal mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mucosa that is part of a pharynx [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001047" + }, { + "val" : "EMAPA:26957" + }, { + "val" : "FMA:55031" + }, { + "val" : "MA:0003143" + }, { + "val" : "SCTID:362121003" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001027", - "lbl" : "sensory nerve", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001032", - "lbl" : "sensory system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001040", - "lbl" : "yolk sac", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001041", - "lbl" : "foregut", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001042", - "lbl" : "chordate pharynx", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001043", - "lbl" : "esophagus", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000358", + "lbl" : "blastocyst", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO].", + "xrefs" : [ "GO:0001824", "Wikipedia:Blastocyst" ] + }, + "xrefs" : [ { + "val" : "BTO:0001099" + }, { + "val" : "CALOHA:TS-0076" + }, { + "val" : "EFO:0000295" + }, { + "val" : "EMAPA:36035" + }, { + "val" : "EV:0100394" + }, { + "val" : "FMA:83041" + }, { + "val" : "GAID:1153" + }, { + "val" : "MESH:D001755" + }, { + "val" : "NCIT:C13739" + }, { + "val" : "SCTID:308837009" + }, { + "val" : "Wikipedia:Blastocyst" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001048", - "lbl" : "primordium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001049", - "lbl" : "neural tube", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001062", - "lbl" : "anatomical entity", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000361", + "lbl" : "red bone marrow", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/red+marrow" ] + }, + "xrefs" : [ { + "val" : "BTO:0001160" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:74595" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "SCTID:328538003" + }, { + "val" : "SCTID:75330005" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001068", - "lbl" : "skin of back", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001070", - "lbl" : "external carotid artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000371", + "lbl" : "syncytiotrophoblast", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated).", + "xrefs" : [ "Wikipedia:Syncytiotrophoblast", "http://embryology.med.unsw.edu.au/Notes/placenta5.htm" ] + }, + "xrefs" : [ { + "val" : "BTO:0001335" + }, { + "val" : "EHDAA:129" + }, { + "val" : "EHDAA:91" + }, { + "val" : "EMAPA:16068" + }, { + "val" : "FMA:83040" + }, { + "val" : "NCIT:C33918" + }, { + "val" : "SCTID:256965005" + }, { + "val" : "Wikipedia:Syncytiotrophoblast" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001071", - "lbl" : "superficial cervical artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000377", + "lbl" : "maxillary nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses.", + "xrefs" : [ "MP:0009799", "Wikipedia:Maxillary_nerve" ] + }, + "xrefs" : [ { + "val" : "AAO:0010670" + }, { + "val" : "BTO:0001378" + }, { + "val" : "EHDAA2:0002087" + }, { + "val" : "EMAPA:17799" + }, { + "val" : "FMA:52724" + }, { + "val" : "GAID:836" + }, { + "val" : "MA:0001103" + }, { + "val" : "MESH:D008442" + }, { + "val" : "SCTID:280211001" + }, { + "val" : "VHOG:0001346" + }, { + "val" : "Wikipedia:Maxillary_nerve" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001072", - "lbl" : "inferior vena cava", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000379", + "lbl" : "tracheal mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mucosa that is part of a respiratory airway.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001390" + }, { + "val" : "FMA:7471" + }, { + "val" : "SCTID:660006" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001074", - "lbl" : "pericardial cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001081", - "lbl" : "endocardium of ventricle", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001082", - "lbl" : "epicardium of ventricle", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001083", - "lbl" : "myocardium of ventricle", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001084", - "lbl" : "skin of head", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001085", - "lbl" : "skin of trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001087", - "lbl" : "pleural fluid", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001090", - "lbl" : "synovial fluid", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001096", - "lbl" : "wall of esophagus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001103", - "lbl" : "diaphragm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001133", - "lbl" : "cardiac muscle tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001134", - "lbl" : "skeletal muscle tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001135", - "lbl" : "smooth muscle tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001136", - "lbl" : "mesothelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001137", - "lbl" : "dorsum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001145", - "lbl" : "ovarian vein", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001167", - "lbl" : "wall of stomach", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001178", - "lbl" : "visceral peritoneum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001179", - "lbl" : "peritoneal cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001190", - "lbl" : "ovarian artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000383", + "lbl" : "musculature of body", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified].", + "xrefs" : [ "VSAO:0000033" ] + }, + "xrefs" : [ { + "val" : "AAO:0000307" + }, { + "val" : "BILA:0000088" + }, { + "val" : "BTO:0001369" + }, { + "val" : "BTO:0001485" + }, { + "val" : "EFO:0000801" + }, { + "val" : "FMA:72954" + }, { + "val" : "MA:0002888" + }, { + "val" : "MAT:0000025" + }, { + "val" : "MIAA:0000025" + }, { + "val" : "VSAO:0000033" + }, { + "val" : "XAO:0004042" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001199", - "lbl" : "mucosa of stomach", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001200", - "lbl" : "submucosa of stomach", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001201", - "lbl" : "serosa of stomach", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001268", - "lbl" : "peritoneal fluid", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001276", - "lbl" : "epithelium of stomach", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001366", - "lbl" : "parietal peritoneum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001416", - "lbl" : "skin of abdomen", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001417", - "lbl" : "skin of neck", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001418", - "lbl" : "skin of thorax", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001421", - "lbl" : "pectoral girdle region", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001434", - "lbl" : "skeletal system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001444", - "lbl" : "subdivision of head", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001456", - "lbl" : "face", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001458", - "lbl" : "skin of lip", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001474", - "lbl" : "bone element", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001484", - "lbl" : "articular capsule", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001496", - "lbl" : "ascending aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000389", + "lbl" : "lens cortex", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Tissue that surrounds the lens nucleus.", + "xrefs" : [ "http://www.thefreedictionary.com/lens+cortex" ] + }, + "xrefs" : [ { + "val" : "BTO:0001632" + }, { + "val" : "CALOHA:TS-0542" + }, { + "val" : "FMA:58970" + }, { + "val" : "MESH:D007904" + }, { + "val" : "SCTID:280626006" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001508", - "lbl" : "arch of aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000390", + "lbl" : "lens nucleus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The core of the crystalline lens, surrounded by the cortex.", + "xrefs" : [ "BTO:0001633" ] + }, + "xrefs" : [ { + "val" : "BTO:0001633" + }, { + "val" : "FMA:58971" + }, { + "val" : "MESH:D007907" + }, { + "val" : "SCTID:280628007" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001514", - "lbl" : "descending aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000397", + "lbl" : "colonic epithelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelium that is part of a colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001709" + }, { + "val" : "CALOHA:TS-0163" + }, { + "val" : "EMAPA:18941" + }, { + "val" : "FMA:17302" + }, { + "val" : "MA:0003195" + }, { + "val" : "SCTID:42978003" + }, { + "val" : "TAO:0005128" + }, { + "val" : "ZFA:0005128" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001515", - "lbl" : "thoracic aorta", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001516", - "lbl" : "abdominal aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000409", + "lbl" : "serous gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland in which the principal secretory cells are serous secreting cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ] + }, + "xrefs" : [ { + "val" : "BTO:0001837" + }, { + "val" : "FMA:62889" + }, { + "val" : "Wikipedia:Serous_gland" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001529", - "lbl" : "brachiocephalic artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000410", + "lbl" : "bronchial mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mucosa that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001846" + }, { + "val" : "FMA:62652" + }, { + "val" : "SCTID:30802009" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001530", - "lbl" : "common carotid artery plus branches", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "lbl" : "mucous gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland in which the principal secretory cells are mucus secreting cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ] + }, + "xrefs" : [ { + "val" : "AAO:0010601" + }, { + "val" : "BTO:0001979" + }, { + "val" : "FMA:62888" + }, { + "val" : "Wikipedia:Mucous_gland" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001533", - "lbl" : "subclavian artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000415", + "lbl" : "artery wall", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An anatomical wall that is part of an artery [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002009" + }, { + "val" : "FMA:14155" + }, { + "val" : "galen:ArterialWall" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001534", - "lbl" : "right subclavian artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000440", + "lbl" : "trabecula", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP].", + "xrefs" : [ "GO:0060343", "Wikipedia:Trabecula" ] + }, + "xrefs" : [ { + "val" : "BTO:0002501" + }, { + "val" : "FMA:85273" + }, { + "val" : "Wikipedia:Trabecula" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001555", - "lbl" : "digestive tract", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000456", + "lbl" : "secretion of exocrine gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of organism substance that is produced by exocrine glands.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0001005" + }, { + "val" : "BTO:0002977" + }, { + "val" : "BTO:0002979" + }, { + "val" : "EMAPA:36535" + }, { + "val" : "FMA:9675" + }, { + "val" : "MA:0002504" + }, { + "val" : "MESH:D012634" + }, { + "val" : "NCIT:C34062" + }, { + "val" : "galen:Secretion" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001558", - "lbl" : "lower respiratory tract", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000463", + "lbl" : "organism substance", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010839" + }, { + "val" : "AEO:0000004" + }, { + "val" : "BILA:0000004" + }, { + "val" : "CALOHA:TS-2101" + }, { + "val" : "CARO:0000004" + }, { + "val" : "EHDAA2:0003004" + }, { + "val" : "EMAPA:35178" + }, { + "val" : "FMA:9669" + }, { + "val" : "HAO:0000004" + }, { + "val" : "MA:0002450" + }, { + "val" : "NCIT:C13236" + }, { + "val" : "SPD:0000008" + }, { + "val" : "TAO:0001487" + }, { + "val" : "TGMA:0001824" + }, { + "val" : "VHOG:0001726" + }, { + "val" : "XAO:0004001" + }, { + "val" : "ZFA:0001487" + }, { + "val" : "galen:BodySubstance" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001584", - "lbl" : "left subclavian artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0000464", + "lbl" : "anatomical space", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] - } - }, { + "definition" : { + "val" : "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010110" + }, { + "val" : "AEO:0000005" + }, { + "val" : "BILA:0000005" + }, { + "val" : "CARO:0000005" + }, { + "val" : "EHDAA2:0003005" + }, { + "val" : "FMA:5897" + }, { + "val" : "HAO:0000005" + }, { + "val" : "NCIT:C94478" + }, { + "val" : "TAO:0001668" + }, { + "val" : "TGMA:0001825" + }, { + "val" : "VHOG:0001728" + }, { + "val" : "XAO:0003190" + }, { + "val" : "ZFA:0001643" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000465", + "lbl" : "material anatomical entity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical entity that has mass.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010264" + }, { + "val" : "AEO:0000006" + }, { + "val" : "BILA:0000006" + }, { + "val" : "CARO:0000006" + }, { + "val" : "EHDAA2:0003006" + }, { + "val" : "FMA:67165" + }, { + "val" : "HAO:0000006" + }, { + "val" : "TAO:0001836" + }, { + "val" : "TGMA:0001826" + }, { + "val" : "VHOG:0001721" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000466", + "lbl" : "immaterial anatomical entity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical entity that has no mass.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010265" + }, { + "val" : "AEO:0000007" + }, { + "val" : "BILA:0000007" + }, { + "val" : "CARO:0000007" + }, { + "val" : "EHDAA2:0003007" + }, { + "val" : "FMA:67112" + }, { + "val" : "HAO:0000007" + }, { + "val" : "TAO:0001835" + }, { + "val" : "TGMA:0001827" + }, { + "val" : "VHOG:0001727" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000467", + "lbl" : "anatomical system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.", + "xrefs" : [ "CARO:0000011" ] + }, + "xrefs" : [ { + "val" : "AAO:0000007" + }, { + "val" : "AEO:0000011" + }, { + "val" : "BILA:0000011" + }, { + "val" : "BIRNLEX:14" + }, { + "val" : "BSA:0000049" + }, { + "val" : "CALOHA:TS-2088" + }, { + "val" : "CARO:0000011" + }, { + "val" : "EHDAA2:0003011" + }, { + "val" : "EHDAA:392" + }, { + "val" : "EMAPA:16103" + }, { + "val" : "EV:0100000" + }, { + "val" : "FMA:7149" + }, { + "val" : "HAO:0000011" + }, { + "val" : "MA:0000003" + }, { + "val" : "NCIT:C12919" + }, { + "val" : "SCTID:278195005" + }, { + "val" : "TAO:0001439" + }, { + "val" : "TGMA:0001831" + }, { + "val" : "VHOG:0001725" + }, { + "val" : "WBbt:0005746" + }, { + "val" : "WBbt:0005763" + }, { + "val" : "Wikipedia:Organ_system" + }, { + "val" : "XAO:0003002" + }, { + "val" : "ZFA:0001439" + }, { + "val" : "galen:AnatomicalSystem" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000468", + "lbl" : "multicellular organism", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that is an individual member of a species and consists of more than one cell.", + "xrefs" : [ "CARO:0000012", "Wikipedia:Multi-cellular_organism", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010026" + }, { + "val" : "AEO:0000191" + }, { + "val" : "BILA:0000012" + }, { + "val" : "BIRNLEX:18" + }, { + "val" : "BSA:0000038" + }, { + "val" : "BTO:0000042" + }, { + "val" : "CARO:0000012" + }, { + "val" : "EFO:0002906" + }, { + "val" : "EHDAA2:0003103" + }, { + "val" : "EHDAA2:0003191" + }, { + "val" : "EHDAA:1" + }, { + "val" : "EMAPA:25765" + }, { + "val" : "EV:0100016" + }, { + "val" : "FMA:256135" + }, { + "val" : "HAO:0000012" + }, { + "val" : "NCIT:C13041" + }, { + "val" : "SCTID:243928005" + }, { + "val" : "TADS:0000001" + }, { + "val" : "TAO:0001094" + }, { + "val" : "TGMA:0001832" + }, { + "val" : "VHOG:0000671" + }, { + "val" : "WBbt:0007833" + }, { + "val" : "Wikipedia:Multi-cellular_organism" + }, { + "val" : "XAO:0003004" + }, { + "val" : "ZFA:0001094" + }, { + "val" : "galen:Organism" + }, { + "val" : "ncithesaurus:Whole_Organism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000471", + "lbl" : "compound organ component", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that is part of a compound organ.", + "xrefs" : [ "CARO:0000019", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010017" + }, { + "val" : "AEO:0000019" + }, { + "val" : "BILA:0000019" + }, { + "val" : "CARO:0000019" + }, { + "val" : "EHDAA2:0003019" + }, { + "val" : "HAO:0000019" + }, { + "val" : "TAO:0001489" + }, { + "val" : "TGMA:0001835" + }, { + "val" : "XAO:0003039" + }, { + "val" : "ZFA:0001489" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000474", + "lbl" : "female reproductive system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The organs and associated structures associated with bearing offspring in a female animal.", + "xrefs" : [ "MP:0001119", "Wikipedia:Female_genitalia", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000083" + }, { + "val" : "CALOHA:TS-1303" + }, { + "val" : "EFO:0000969" + }, { + "val" : "EHDAA2:0000506" + }, { + "val" : "EHDAA:8116" + }, { + "val" : "EMAPA:17959" + }, { + "val" : "EV:0100110" + }, { + "val" : "FMA:45663" + }, { + "val" : "GAID:364" + }, { + "val" : "HAO:0000324" + }, { + "val" : "MA:0000381" + }, { + "val" : "MESH:D005836" + }, { + "val" : "MIAA:0000028" + }, { + "val" : "NCIT:C12402" + }, { + "val" : "SCTID:361386004" + }, { + "val" : "TGMA:0000635" + }, { + "val" : "VHOG:0000726" + }, { + "val" : "Wikipedia:Female_genitalia" + }, { + "val" : "WikipediaCategory:Female_reproductive_system" + }, { + "val" : "XAO:0000156" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000475", + "lbl" : "organism subdivision", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument.", + "xrefs" : [ "CARO:0000032", "CARO:DOS", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010053" + }, { + "val" : "AEO:0000032" + }, { + "val" : "BILA:0000032" + }, { + "val" : "BIRNLEX:7" + }, { + "val" : "CALOHA:TS-2084" + }, { + "val" : "CARO:0000032" + }, { + "val" : "EFO:0000808" + }, { + "val" : "EHDAA2:0003032" + }, { + "val" : "EMAPA:36031" + }, { + "val" : "FMA:7153" + }, { + "val" : "HAO:0000032" + }, { + "val" : "MA:0002433" + }, { + "val" : "MAT:0000293" + }, { + "val" : "MESH:D001829" + }, { + "val" : "MIAA:0000293" + }, { + "val" : "NCIT:C32221" + }, { + "val" : "TAO:0001308" + }, { + "val" : "TGMA:0001840" + }, { + "val" : "VHOG:0001758" + }, { + "val" : "Wikipedia:Body_part" + }, { + "val" : "XAO:0003013" + }, { + "val" : "ZFA:0001308" + }, { + "val" : "galen:BodyPart" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000476", + "lbl" : "acellular anatomical structure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010268" + }, { + "val" : "AEO:0000040" + }, { + "val" : "BILA:0000040" + }, { + "val" : "CARO:0000040" + }, { + "val" : "EHDAA2:0003040" + }, { + "val" : "FMA:63863" + }, { + "val" : "HAO:0000040" + }, { + "val" : "TAO:0000382" + }, { + "val" : "TGMA:0001841" + }, { + "val" : "XAO:0003162" + }, { + "val" : "ZFA:0000382" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000477", + "lbl" : "anatomical cluster", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical group whose component anatomical structures lie in close proximity to each other.", + "xrefs" : [ "FBbt:00007277" ] + }, + "xrefs" : [ { + "val" : "VHOG:0001737" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000478", + "lbl" : "extraembryonic structure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis.", + "xrefs" : [ "CARO:DOS", "http://orcid.org/0000-0001-9114-8737", "https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279" ] + }, + "comments" : [ "see also conceptus extraembryonic component in EHDAA2." ], + "xrefs" : [ { + "val" : "AAO:0010020" + }, { + "val" : "AEO:0000042" + }, { + "val" : "BILA:0000042" + }, { + "val" : "CALOHA:TS-2119" + }, { + "val" : "CARO:0000042" + }, { + "val" : "EHDAA2:0003042" + }, { + "val" : "EHDAA:46" + }, { + "val" : "FMA:85537" + }, { + "val" : "HAO:0000042" + }, { + "val" : "NCIT:C34055" + }, { + "val" : "SCTID:314908006" + }, { + "val" : "TAO:0000020" + }, { + "val" : "TGMA:0001843" + }, { + "val" : "VHOG:0000292" + }, { + "val" : "XAO:0004005" + }, { + "val" : "ZFA:0000020" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000479", + "lbl" : "tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation.", + "xrefs" : [ "CARO:0000043" ] + }, + "xrefs" : [ { + "val" : "AAO:0000607" + }, { + "val" : "AAO:0010054" + }, { + "val" : "AEO:0000043" + }, { + "val" : "BILA:0000043" + }, { + "val" : "BIRNLEX:19" + }, { + "val" : "CALOHA:TS-2090" + }, { + "val" : "CARO:0000043" + }, { + "val" : "EHDAA2:0003043" + }, { + "val" : "EMAPA:35868" + }, { + "val" : "FMA:9637" + }, { + "val" : "HAO:0000043" + }, { + "val" : "MA:0003002" + }, { + "val" : "MESH:D014024" + }, { + "val" : "NCIT:C12801" + }, { + "val" : "TAO:0001477" + }, { + "val" : "TGMA:0001844" + }, { + "val" : "VHOG:0001757" + }, { + "val" : "WBbt:0005729" + }, { + "val" : "XAO:0003040" + }, { + "val" : "ZFA:0001477" + }, { + "val" : "galen:Tissue" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000481", + "lbl" : "multi-tissue structure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types.", + "xrefs" : [ "CARO:0000055", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010048" + }, { + "val" : "AEO:0000055" + }, { + "val" : "BILA:0000055" + }, { + "val" : "CARO:0000055" + }, { + "val" : "EHDAA2:0003055" + }, { + "val" : "HAO:0000055" + }, { + "val" : "TAO:0001488" + }, { + "val" : "TGMA:0001847" + }, { + "val" : "VHOG:0001762" + }, { + "val" : "XAO:0003037" + }, { + "val" : "ZFA:0001488" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000483", + "lbl" : "epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO].", + "xrefs" : [ "Wikipedia:Epithelium", "http://orcid.org/0000-0001-9114-8737" ] + }, + "comments" : [ "Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it?" ], + "xrefs" : [ { + "val" : "AAO:0000144" + }, { + "val" : "AAO:0010055" + }, { + "val" : "AEO:0000066" + }, { + "val" : "BILA:0000066" + }, { + "val" : "BTO:0000416" + }, { + "val" : "CALOHA:TS-0288" + }, { + "val" : "CARO:0000066" + }, { + "val" : "EHDAA2:0003066" + }, { + "val" : "EMAPA:32738" + }, { + "val" : "FMA:9639" + }, { + "val" : "GAID:402" + }, { + "val" : "HAO:0000066" + }, { + "val" : "MA:0003060" + }, { + "val" : "MESH:D004848" + }, { + "val" : "NCIT:C12710" + }, { + "val" : "SCTID:31610004" + }, { + "val" : "TAO:0001486" + }, { + "val" : "VHOG:0000387" + }, { + "val" : "Wikipedia:Epithelium" + }, { + "val" : "XAO:0003045" + }, { + "val" : "ZFA:0001486" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000484", + "lbl" : "simple cuboidal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Unilaminar epithelium that consists of a single layer of cuboidal cells.", + "xrefs" : [ "Wikipedia:Simple_cuboidal_epithelium", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010064" + }, { + "val" : "AEO:0000067" + }, { + "val" : "BILA:0000067" + }, { + "val" : "CARO:0000067" + }, { + "val" : "EHDAA2:0003067" + }, { + "val" : "FMA:45566" + }, { + "val" : "HAO:0000067" + }, { + "val" : "NCIT:C33553" + }, { + "val" : "TAO:0001497" + }, { + "val" : "Wikipedia:Simple_cuboidal_epithelium" + }, { + "val" : "XAO:0004009" + }, { + "val" : "ZFA:0001497" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000485", + "lbl" : "simple columnar epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA].", + "xrefs" : [ "FMA:FMA", "Wikipedia:Simple_columnar_epithelium", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010063" + }, { + "val" : "AEO:0000068" + }, { + "val" : "BILA:0000068" + }, { + "val" : "CARO:0000068" + }, { + "val" : "EHDAA2_RETIRED:0003068" + }, { + "val" : "FMA:45567" + }, { + "val" : "HAO:0000068" + }, { + "val" : "NCIT:C33552" + }, { + "val" : "SCTID:32210007" + }, { + "val" : "TAO:0001496" + }, { + "val" : "Wikipedia:Simple_columnar_epithelium" + }, { + "val" : "XAO:0004008" + }, { + "val" : "ZFA:0001496" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000486", + "lbl" : "multilaminar epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA].", + "xrefs" : [ "FMA:FMA", "Wikipedia:Stratified_epithelium", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010059" + }, { + "val" : "AEO:0000069" + }, { + "val" : "BILA:0000069" + }, { + "val" : "BTO:0002074" + }, { + "val" : "CARO:0000069" + }, { + "val" : "EHDAA2:0003069" + }, { + "val" : "FMA:45562" + }, { + "val" : "HAO:0000069" + }, { + "val" : "NCIT:C33622" + }, { + "val" : "SCTID:309044005" + }, { + "val" : "TAO:0001494" + }, { + "val" : "Wikipedia:Stratified_epithelium" + }, { + "val" : "XAO:0004006" + }, { + "val" : "ZFA:0001494" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000487", + "lbl" : "simple squamous epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA].", + "xrefs" : [ "FMA:45565", "Wikipedia:Simple_squamous_epithelium", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010066" + }, { + "val" : "AEO:0000070" + }, { + "val" : "BILA:0000070" + }, { + "val" : "BTO:0002073" + }, { + "val" : "CARO:0000070" + }, { + "val" : "EHDAA2:0003070" + }, { + "val" : "FMA:45565" + }, { + "val" : "HAO:0000070" + }, { + "val" : "NCIT:C13178" + }, { + "val" : "TAO:0001498" + }, { + "val" : "Wikipedia:Simple_squamous_epithelium" + }, { + "val" : "XAO:0004010" + }, { + "val" : "ZFA:0001498" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000488", + "lbl" : "atypical epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium that consists of epithelial cells not arranged in one ore more layers.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010057" + }, { + "val" : "AEO:0000071" + }, { + "val" : "BILA:0000071" + }, { + "val" : "CARO:0000071" + }, { + "val" : "EHDAA2:0003071" + }, { + "val" : "FMA:61741" + }, { + "val" : "HAO:0000071" + }, { + "val" : "TAO:0001493" + }, { + "val" : "XAO:0004004" + }, { + "val" : "ZFA:0001493" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000489", + "lbl" : "cavitated compound organ", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Compound organ that contains one or more macroscopic anatomical spaces.", + "xrefs" : [ "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010016" + }, { + "val" : "AEO:0000072" + }, { + "val" : "BILA:0000072" + }, { + "val" : "CARO:0000072" + }, { + "val" : "EHDAA2:0003072" + }, { + "val" : "FMA:55671" + }, { + "val" : "HAO:0000072" + }, { + "val" : "TAO:0001490" + }, { + "val" : "TGMA:0001857" + }, { + "val" : "VHOG:0001730" + }, { + "val" : "XAO:0003165" + }, { + "val" : "ZFA:0001490" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000490", + "lbl" : "unilaminar epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA].", + "xrefs" : [ "FMA:45561", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010062" + }, { + "val" : "AEO:0000073" + }, { + "val" : "BILA:0000073" + }, { + "val" : "BTO:0002073" + }, { + "val" : "CARO:0000073" + }, { + "val" : "EHDAA2:0003073" + }, { + "val" : "FMA:45561" + }, { + "val" : "HAO:0000073" + }, { + "val" : "NCIT:C33554" + }, { + "val" : "SCTID:309043004" + }, { + "val" : "TAO:0001495" + }, { + "val" : "XAO:0004007" + }, { + "val" : "ZFA:0001495" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "lbl" : "mucus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water.", + "xrefs" : [ "Wikipedia:Mucus" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2144" + }, { + "val" : "ENVO:02000040" + }, { + "val" : "FMA:66938" + }, { + "val" : "GAID:1164" + }, { + "val" : "MESH:D009093" + }, { + "val" : "NCIT:C13259" + }, { + "val" : "Wikipedia:Mucus" + }, { + "val" : "galen:Mucus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000915", + "lbl" : "thoracic segment of trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of trunk that lies between the head and the abdomen.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35862" + }, { + "val" : "FMA:259209" + }, { + "val" : "MA:0000022" + }, { + "val" : "SCTID:302551006" + }, { + "val" : "Wikipedia:Thorax" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000916", + "lbl" : "abdomen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000020" + }, { + "val" : "CALOHA:TS-0001" + }, { + "val" : "EFO:0000968" + }, { + "val" : "EMAPA:35102" + }, { + "val" : "EV:0100011" + }, { + "val" : "FMA:9577" + }, { + "val" : "GAID:16" + }, { + "val" : "MA:0000029" + }, { + "val" : "MAT:0000298" + }, { + "val" : "MESH:D000005" + }, { + "val" : "MIAA:0000298" + }, { + "val" : "SCTID:302553009" + }, { + "val" : "Wikipedia:Abdomen" + }, { + "val" : "galen:Abdomen" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000922", + "lbl" : "embryo", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.", + "xrefs" : [ "BTO:0000379", "FB:FBrf0039741", "FB:FBrf0041814", "GO:0009790", "Wikipedia:Embryo" ] + }, + "xrefs" : [ { + "val" : "AAO:0011035" + }, { + "val" : "AEO:0000169" + }, { + "val" : "BILA:0000056" + }, { + "val" : "BSA:0000039" + }, { + "val" : "BTO:0000379" + }, { + "val" : "CALOHA:TS-0229" + }, { + "val" : "EFO:0001367" + }, { + "val" : "EHDAA2:0000002" + }, { + "val" : "EHDAA2_RETIRED:0003236" + }, { + "val" : "EHDAA:38" + }, { + "val" : "EMAPA:16039" + }, { + "val" : "FMA:69068" + }, { + "val" : "GAID:963" + }, { + "val" : "MAT:0000226" + }, { + "val" : "MESH:D004622" + }, { + "val" : "MIAA:0000019" + }, { + "val" : "NCIT:C28147" + }, { + "val" : "OGEM:000001" + }, { + "val" : "SCTID:57991002" + }, { + "val" : "VHOG:0001766" + }, { + "val" : "Wikipedia:Embryo" + }, { + "val" : "XAO:0000113" + }, { + "val" : "ZFA:0000103" + }, { + "val" : "http://neurolex.org/wiki/Category:Embryonic_organism" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000923", + "lbl" : "germ layer", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm.", + "xrefs" : [ "Wikipedia:Germ_layer", "https://github.com/obophenotype/uberon/issues/203" ] + }, + "comments" : [ "Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest]" ], + "xrefs" : [ { + "val" : "AAO:0000480" + }, { + "val" : "BILA:0000035" + }, { + "val" : "BTO:0000556" + }, { + "val" : "EMAPA:36033" + }, { + "val" : "FMA:69069" + }, { + "val" : "GAID:1303" + }, { + "val" : "MESH:D005855" + }, { + "val" : "NCIT:C12950" + }, { + "val" : "NCIT:C54105" + }, { + "val" : "TAO:0001122" + }, { + "val" : "VHOG:0001223" + }, { + "val" : "Wikipedia:Germ_layer" + }, { + "val" : "XAO:0003011" + }, { + "val" : "ZFA:0001122" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000924", + "lbl" : "ectoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.", + "xrefs" : [ "Wikipedia:Ectoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0000137" + }, { + "val" : "BILA:0000036" + }, { + "val" : "BTO:0000315" + }, { + "val" : "CALOHA:TS-0216" + }, { + "val" : "EFO:0000414" + }, { + "val" : "EHDAA2:0000428" + }, { + "val" : "EMAPA:16069" + }, { + "val" : "EV:0100003" + }, { + "val" : "FMA:69070" + }, { + "val" : "GAID:1304" + }, { + "val" : "MAT:0000155" + }, { + "val" : "MAT:0000173" + }, { + "val" : "MESH:D004475" + }, { + "val" : "MIAA:0000173" + }, { + "val" : "NCIT:C12703" + }, { + "val" : "SCTID:362851007" + }, { + "val" : "TAO:0000016" + }, { + "val" : "VHOG:0000153" + }, { + "val" : "Wikipedia:Ectoderm" + }, { + "val" : "XAO:0000001" + }, { + "val" : "ZFA:0000016" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000925", + "lbl" : "endoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.", + "xrefs" : [ "Wikipedia:Endoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0000139" + }, { + "val" : "BILA:0000038" + }, { + "val" : "BTO:0000800" + }, { + "val" : "CALOHA:TS-0273" + }, { + "val" : "EFO:0002545" + }, { + "val" : "EHDAA2:0000436" + }, { + "val" : "EMAPA:16062" + }, { + "val" : "EV:0100005" + }, { + "val" : "FMA:69071" + }, { + "val" : "GAID:1305" + }, { + "val" : "MAT:0000175" + }, { + "val" : "MESH:D004707" + }, { + "val" : "MIAA:0000175" + }, { + "val" : "NCIT:C12706" + }, { + "val" : "SCTID:362855003" + }, { + "val" : "TAO:0000017" + }, { + "val" : "VHOG:0000154" + }, { + "val" : "Wikipedia:Endoderm" + }, { + "val" : "XAO:0000090" + }, { + "val" : "ZFA:0000017" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000926", + "lbl" : "mesoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The middle germ layer of the embryo, between the endoderm and ectoderm.", + "xrefs" : [ "Wikipedia:Mesoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0000304" + }, { + "val" : "BILA:0000037" + }, { + "val" : "BTO:0000839" + }, { + "val" : "CALOHA:TS-0623" + }, { + "val" : "EFO:0001981" + }, { + "val" : "EHDAA2:0001128" + }, { + "val" : "EHDAA:124" + }, { + "val" : "EHDAA:160" + }, { + "val" : "EHDAA:183" + }, { + "val" : "EMAPA:16083" + }, { + "val" : "EV:0100006" + }, { + "val" : "FMA:69072" + }, { + "val" : "GAID:522" + }, { + "val" : "MAT:0000174" + }, { + "val" : "MESH:D008648" + }, { + "val" : "MIAA:0000174" + }, { + "val" : "NCIT:C12750" + }, { + "val" : "SCTID:362854004" + }, { + "val" : "TAO:0000041" + }, { + "val" : "VHOG:0000152" + }, { + "val" : "Wikipedia:Mesoderm" + }, { + "val" : "XAO:0000050" + }, { + "val" : "ZFA:0000041" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000930", + "lbl" : "stomodeum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity.", + "xrefs" : [ "Wikipedia:Stomodeum", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/326" ] + }, + "xrefs" : [ { + "val" : "BTO:0004224" + }, { + "val" : "EHDAA2:0001929" + }, { + "val" : "EMAPA:16263" + }, { + "val" : "FMA:295846" + }, { + "val" : "NCIT:C34306" + }, { + "val" : "TAO:0001290" + }, { + "val" : "TGMA:0000135" + }, { + "val" : "Wikipedia:Stomodeum" + }, { + "val" : "XAO:0000269" + }, { + "val" : "ZFA:0001290" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "lbl" : "proctodeum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract.", + "xrefs" : [ "ZFA:0000066", "https://github.com/obophenotype/uberon/issues/685", "https://sourceforge.net/p/fbbtdv/tickets/52" ] + }, + "xrefs" : [ { + "val" : "AAO:0011087" + }, { + "val" : "EHDAA2:0000121" + }, { + "val" : "EMAPA:25038" + }, { + "val" : "NCIT:C34278" + }, { + "val" : "TAO:0000066" + }, { + "val" : "VHOG:0000139" + }, { + "val" : "Wikipedia:Proctodeum" + }, { + "val" : "XAO:0001019" + }, { + "val" : "ZFA:0000066" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000945", + "lbl" : "stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Stomach", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000579" + }, { + "val" : "ANISEED:1235297" + }, { + "val" : "BTO:0001307" + }, { + "val" : "CALOHA:TS-0980" + }, { + "val" : "EFO:0000837" + }, { + "val" : "EHDAA2:0001915" + }, { + "val" : "EHDAA:2993" + }, { + "val" : "EMAPA:17021" + }, { + "val" : "EV:0100070" + }, { + "val" : "FMA:7148" + }, { + "val" : "GAID:293" + }, { + "val" : "MA:0000353" + }, { + "val" : "MAT:0000051" + }, { + "val" : "MESH:D013270" + }, { + "val" : "MIAA:0000051" + }, { + "val" : "NCIT:C12391" + }, { + "val" : "SCTID:181246003" + }, { + "val" : "TAO:0002121" + }, { + "val" : "VHOG:0000408" + }, { + "val" : "Wikipedia:Stomach" + }, { + "val" : "XAO:0000128" + }, { + "val" : "galen:Stomach" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000947", + "lbl" : "aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation.", + "xrefs" : [ "ISBN:0-683-40008-8", "MESH:A07.231.114.056", "MP:0000272", "Wikipedia:Aorta", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010213" + }, { + "val" : "BTO:0000135" + }, { + "val" : "CALOHA:TS-0046" + }, { + "val" : "EFO:0000265" + }, { + "val" : "EMAPA:18601" + }, { + "val" : "EV:0100027" + }, { + "val" : "FMA:3734" + }, { + "val" : "GAID:469" + }, { + "val" : "MA:0000062" + }, { + "val" : "MAT:0000035" + }, { + "val" : "MESH:D001011" + }, { + "val" : "MIAA:0000035" + }, { + "val" : "NCIT:C12669" + }, { + "val" : "SCTID:181298001" + }, { + "val" : "VHOG:0001523" + }, { + "val" : "Wikipedia:Aorta" + }, { + "val" : "XAO:0003010" + }, { + "val" : "galen:Aorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000948", + "lbl" : "heart", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ.", + "xrefs" : [ "Wikipedia:Heart", "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Taxon notes:\" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)\" DOI:10.1101/gad.1485706" ], + "xrefs" : [ { + "val" : "AAO:0010210" + }, { + "val" : "BILA:0000020" + }, { + "val" : "BTO:0000562" + }, { + "val" : "CALOHA:TS-0445" + }, { + "val" : "EFO:0000815" + }, { + "val" : "EHDAA2:0000738" + }, { + "val" : "EHDAA:420" + }, { + "val" : "EMAPA:16105" + }, { + "val" : "EV:0100018" + }, { + "val" : "FMA:7088" + }, { + "val" : "GAID:174" + }, { + "val" : "MA:0000072" + }, { + "val" : "MAT:0000036" + }, { + "val" : "MESH:D006321" + }, { + "val" : "MIAA:0000036" + }, { + "val" : "NCIT:C12727" + }, { + "val" : "SCTID:302509004" + }, { + "val" : "TAO:0000114" + }, { + "val" : "VHOG:0000276" + }, { + "val" : "Wikipedia:Heart" + }, { + "val" : "XAO:0000064" + }, { + "val" : "ZFA:0000114" + }, { + "val" : "galen:Heart" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000949", + "lbl" : "endocrine system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.", + "xrefs" : [ "NLM:endocrine+system", "Wikipedia:Endocrine_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0010279" + }, { + "val" : "CALOHA:TS-1301" + }, { + "val" : "EFO:0002969" + }, { + "val" : "EHDAA2:0002224" + }, { + "val" : "EMAPA:35306" + }, { + "val" : "EV:0100128" + }, { + "val" : "FMA:9668" + }, { + "val" : "GAID:439" + }, { + "val" : "MA:0000012" + }, { + "val" : "MESH:D004703" + }, { + "val" : "NCIT:C12705" + }, { + "val" : "SCTID:278876000" + }, { + "val" : "TAO:0001158" + }, { + "val" : "VHOG:0000098" + }, { + "val" : "Wikipedia:Endocrine_system" + }, { + "val" : "XAO:0000158" + }, { + "val" : "ZFA:0001158" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000955", + "lbl" : "brain", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].", + "xrefs" : [ "Wikipedia:Brain", "https://github.com/obophenotype/uberon/issues/300" ] + }, + "xrefs" : [ { + "val" : "AAO:0010478" + }, { + "val" : "ABA:Brain" + }, { + "val" : "BAMS:Br" + }, { + "val" : "BAMS:Brain" + }, { + "val" : "BILA:0000135" + }, { + "val" : "BIRNLEX:796" + }, { + "val" : "BTO:0000142" + }, { + "val" : "CALOHA:TS-0095" + }, { + "val" : "DHBA:10155" + }, { + "val" : "EFO:0000302" + }, { + "val" : "EHDAA2:0000183" + }, { + "val" : "EHDAA:2641" + }, { + "val" : "EHDAA:6485" + }, { + "val" : "EMAPA:16894" + }, { + "val" : "EV:0100164" + }, { + "val" : "FMA:50801" + }, { + "val" : "GAID:571" + }, { + "val" : "HBA:4005" + }, { + "val" : "MA:0000168" + }, { + "val" : "MAT:0000098" + }, { + "val" : "MBA:8" + }, { + "val" : "MBA:997" + }, { + "val" : "MESH:D001921" + }, { + "val" : "MIAA:0000098" + }, { + "val" : "NCIT:C12439" + }, { + "val" : "PBA:3999" + }, { + "val" : "SCTID:258335003" + }, { + "val" : "TAO:0000008" + }, { + "val" : "VHOG:0000157" + }, { + "val" : "Wikipedia:Brain" + }, { + "val" : "XAO:0000010" + }, { + "val" : "ZFA:0000008" + }, { + "val" : "galen:Brain" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000957", + "lbl" : "lamina", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any thin layer or plate.", + "xrefs" : [ "Wikipedia:Lamina_of_the_vertebral_arch" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Lamina_of_the_vertebral_arch" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000962", + "lbl" : "nerve of cervical vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted].", + "xrefs" : [ "Wikipedia:Cervical_nerves" ] + }, + "comments" : [ "Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP]" ], + "xrefs" : [ { + "val" : "BAMS:cern" + }, { + "val" : "FMA:5859" + }, { + "val" : "NCIT:C32299" + }, { + "val" : "NLXANAT:20090207" + }, { + "val" : "SCTID:360497008" + }, { + "val" : "Wikipedia:Cervical_nerves" + }, { + "val" : "neuronames:2351" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000963", + "lbl" : "head sensillum", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "MAT:0000204" + }, { + "val" : "MIAA:0000204" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000964", + "lbl" : "cornea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure.", + "xrefs" : [ "ISBN:0-683-40008-8", "MESH:A09.371.060.217", "MP:0001312" ] + }, + "xrefs" : [ { + "val" : "AAO:0010344" + }, { + "val" : "BTO:0000286" + }, { + "val" : "CALOHA:TS-0171" + }, { + "val" : "EFO:0000377" + }, { + "val" : "EHDAA2:0000316" + }, { + "val" : "EHDAA:10199" + }, { + "val" : "EMAPA:17161" + }, { + "val" : "EV:0100341" + }, { + "val" : "FMA:58238" + }, { + "val" : "GAID:892" + }, { + "val" : "MA:0000266" + }, { + "val" : "MESH:D003315" + }, { + "val" : "NCIT:C12342" + }, { + "val" : "SCTID:181162001" + }, { + "val" : "TAO:0000640" + }, { + "val" : "VHOG:0000164" + }, { + "val" : "Wikipedia:Cornea" + }, { + "val" : "XAO:0000180" + }, { + "val" : "ZFA:0000640" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000965", + "lbl" : "lens of camera-type eye", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina.", + "xrefs" : [ "Wikipedia:Lens_(anatomy)", "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "The lens is avascular and nourished by diffusion from the aqueous and vitreous humors." ], + "xrefs" : [ { + "val" : "AAO:0010348" + }, { + "val" : "BTO:0000723" + }, { + "val" : "CALOHA:TS-0545" + }, { + "val" : "EHDAA:9057" + }, { + "val" : "EMAPA:17838" + }, { + "val" : "EV:0100343" + }, { + "val" : "FMA:58241" + }, { + "val" : "MA:0000275" + }, { + "val" : "MAT:0000141" + }, { + "val" : "MESH:D007908" + }, { + "val" : "MIAA:0000141" + }, { + "val" : "NCIT:C12743" + }, { + "val" : "RETIRED_EHDAA2:0000975" + }, { + "val" : "SCTID:181169005" + }, { + "val" : "TAO:0000035" + }, { + "val" : "VHOG:0000169" + }, { + "val" : "Wikipedia:Lens_(anatomy)" + }, { + "val" : "XAO:0000008" + }, { + "val" : "ZFA:0000035" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000966", + "lbl" : "retina", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.", + "xrefs" : [ "Wikipedia:Retina", "ZFIN:curator" ] + }, + "comments" : [ "Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods" ], + "xrefs" : [ { + "val" : "AAO:0010352" + }, { + "val" : "BAMS:R" + }, { + "val" : "BIRNLEX:1153" + }, { + "val" : "BTO:0001175" + }, { + "val" : "CALOHA:TS-0865" + }, { + "val" : "EFO:0000832" + }, { + "val" : "EHDAA2:0001627" + }, { + "val" : "EHDAA:4757" + }, { + "val" : "EMAPA:17168" + }, { + "val" : "EV:0100348" + }, { + "val" : "FMA:58301" + }, { + "val" : "GAID:755" + }, { + "val" : "MA:0000276" + }, { + "val" : "MAT:0000142" + }, { + "val" : "MBA:304325711" + }, { + "val" : "MESH:D012160" + }, { + "val" : "MIAA:0000142" + }, { + "val" : "NCIT:C12343" + }, { + "val" : "NIFSTD_RETIRED:birnlex_1156" + }, { + "val" : "SCTID:181171005" + }, { + "val" : "TAO:0000152" + }, { + "val" : "VHOG:0000229" + }, { + "val" : "Wikipedia:Retina" + }, { + "val" : "XAO:0000009" + }, { + "val" : "ZFA:0000152" + }, { + "val" : "neuronames:1862" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000970", + "lbl" : "eye", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that detects light.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BILA:0000017" + }, { + "val" : "BTO:0000439" + }, { + "val" : "CALOHA:TS-0309" + }, { + "val" : "EFO:0000827" + }, { + "val" : "EV:0100336" + }, { + "val" : "GAID:69" + }, { + "val" : "MAT:0000140" + }, { + "val" : "MESH:D005123" + }, { + "val" : "MIAA:0000140" + }, { + "val" : "Wikipedia:Eye" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000971", + "lbl" : "ommatidium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells.", + "xrefs" : [ "PMID:21062451" ] + }, + "xrefs" : [ { + "val" : "BTO:0001922" + }, { + "val" : "HAO:0000666" + }, { + "val" : "MAT:0000143" + }, { + "val" : "MIAA:0000143" + }, { + "val" : "Wikipedia:Ommatidium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000974", + "lbl" : "neck", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0000108" + }, { + "val" : "BTO:0000420" + }, { + "val" : "CALOHA:TS-2045" + }, { + "val" : "EFO:0000967" + }, { + "val" : "EHDAA2:0003108" + }, { + "val" : "EMAPA:35587" + }, { + "val" : "FMA:7155" + }, { + "val" : "GAID:86" + }, { + "val" : "MA:0000024" + }, { + "val" : "MAT:0000297" + }, { + "val" : "MESH:D009333" + }, { + "val" : "MIAA:0000297" + }, { + "val" : "NCIT:C13063" + }, { + "val" : "SCTID:302550007" + }, { + "val" : "Wikipedia:Neck" + }, { + "val" : "galen:Neck" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000977", + "lbl" : "pleura", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion).", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010820", "UBERON:cjm", "Wikipedia:Pulmonary_pleurae", "https://github.com/obophenotype/uberon/issues/1231" ] + }, + "xrefs" : [ { + "val" : "BTO:0001791" + }, { + "val" : "CALOHA:TS-2081" + }, { + "val" : "EFO:0001980" + }, { + "val" : "EV:0100044" + }, { + "val" : "FMA:9583" + }, { + "val" : "GAID:360" + }, { + "val" : "MA:0000433" + }, { + "val" : "MESH:D010994" + }, { + "val" : "NCIT:C12469" + }, { + "val" : "SCTID:181609007" + }, { + "val" : "VHOG:0000394" + }, { + "val" : "Wikipedia:Pleura" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000982", + "lbl" : "skeletal joint", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO].", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000101", "Wikipedia:Joint", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AEO:0000182" + }, { + "val" : "BTO:0001686" + }, { + "val" : "CALOHA:TS-2023" + }, { + "val" : "EFO:0000948" + }, { + "val" : "EMAPA:35456" + }, { + "val" : "FMA:7490" + }, { + "val" : "GAID:102" + }, { + "val" : "MA:0000319" + }, { + "val" : "MAT:0000188" + }, { + "val" : "MESH:D007596" + }, { + "val" : "MIAA:0000188" + }, { + "val" : "NCIT:C13044" + }, { + "val" : "RETIRED_EHDAA2:0003182" + }, { + "val" : "SCTID:302536002" + }, { + "val" : "TAO:0000367" + }, { + "val" : "VHOG:0001276" + }, { + "val" : "VSAO:0000101" + }, { + "val" : "Wikipedia:Joint" + }, { + "val" : "XAO:0000171" + }, { + "val" : "ZFA:0001596" + }, { + "val" : "galen:Joint" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000988", + "lbl" : "pons", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum.", + "xrefs" : [ "VHOG:0001176" ] + }, + "xrefs" : [ { + "val" : "BAMS:PONS" + }, { + "val" : "BAMS:Pons" + }, { + "val" : "BIRNLEX:733" + }, { + "val" : "BM:Pons" + }, { + "val" : "BTO:0001101" + }, { + "val" : "CALOHA:TS-0813" + }, { + "val" : "DHBA:10661" + }, { + "val" : "EFO:0001394" + }, { + "val" : "EHDAA2:0004394" + }, { + "val" : "EMAPA:17563" + }, { + "val" : "EV:0100253" + }, { + "val" : "FMA:67943" + }, { + "val" : "GAID:578" + }, { + "val" : "HBA:9131" + }, { + "val" : "MA:0000204" + }, { + "val" : "MAT:0000115" + }, { + "val" : "MBA:771" + }, { + "val" : "MESH:D011149" + }, { + "val" : "MIAA:0000115" + }, { + "val" : "NCIT:C12511" + }, { + "val" : "SCTID:279103004" + }, { + "val" : "VHOG:0001176" + }, { + "val" : "Wikipedia:Pons" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000990", + "lbl" : "reproductive system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that has as its parts the organs concerned with reproduction.", + "xrefs" : [ "Wikipedia:Reproductive_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0010258" + }, { + "val" : "BILA:0000103" + }, { + "val" : "BTO:0000081" + }, { + "val" : "CALOHA:TS-1318" + }, { + "val" : "EFO:0000809" + }, { + "val" : "EHDAA2:0001603" + }, { + "val" : "EHDAA:5923" + }, { + "val" : "EMAPA:17381" + }, { + "val" : "EV:0100100" + }, { + "val" : "FMA:7160" + }, { + "val" : "GAID:363" + }, { + "val" : "HAO:0000374" + }, { + "val" : "HAO:0000895" + }, { + "val" : "MA:0000326" + }, { + "val" : "MIAA:0000305" + }, { + "val" : "NCIT:C12841" + }, { + "val" : "SCTID:278875001" + }, { + "val" : "TAO:0000632" + }, { + "val" : "VHOG:0000182" + }, { + "val" : "WBbt:0005747" + }, { + "val" : "Wikipedia:Reproductive_system" + }, { + "val" : "XAO:0000142" + }, { + "val" : "ZFA:0000632" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000991", + "lbl" : "gonad", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Reproductive organ that produces and releases eggs (ovary) or sperm (testis).", + "xrefs" : [ "ISBN:0140512888", "Wikipedia:Gonad", "ZFA:0000413", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0000213" + }, { + "val" : "BILA:0000123" + }, { + "val" : "BSA:0000079" + }, { + "val" : "BTO:0000534" + }, { + "val" : "EMAPA:17383" + }, { + "val" : "FMA:18250" + }, { + "val" : "GAID:368" + }, { + "val" : "HAO:0000379" + }, { + "val" : "MA:0002420" + }, { + "val" : "MESH:D006066" + }, { + "val" : "NCIT:C12725" + }, { + "val" : "SCTID:304623008" + }, { + "val" : "TAO:0000413" + }, { + "val" : "VHOG:0000397" + }, { + "val" : "WBbt:0005175" + }, { + "val" : "Wikipedia:Gonad" + }, { + "val" : "XAO:0003146" + }, { + "val" : "ZFA:0000413" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0000992", + "lbl" : "ovary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The gonad of a female organism which contains germ cells.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0001126", "Wikipedia:Ovary" ] + }, + "xrefs" : [ { + "val" : "AAO:0000371" + }, { + "val" : "BILA:0000125" + }, { + "val" : "BSA:0000080" + }, { + "val" : "BTO:0000975" + }, { + "val" : "CALOHA:TS-0730" + }, { + "val" : "EFO:0000973" + }, { + "val" : "EHDAA2:0001360" + }, { + "val" : "EHDAA:8124" + }, { + "val" : "EMAPA:17962" + }, { + "val" : "EV:0100111" + }, { + "val" : "FMA:7209" + }, { + "val" : "GAID:367" + }, { + "val" : "MA:0000384" + }, { + "val" : "MESH:D010053" + }, { + "val" : "MIAA:0000125" + }, { + "val" : "NCIT:C12404" + }, { + "val" : "SCTID:181464007" + }, { + "val" : "TAO:0000403" + }, { + "val" : "VHOG:0000251" + }, { + "val" : "Wikipedia:Ovary" + }, { + "val" : "XAO:0000258" + }, { + "val" : "ZFA:0000403" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001003", + "lbl" : "skin epidermis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outer epithelial layer of the skin that is superficial to the dermis.", + "xrefs" : [ "ISBN:0073040584", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000143" + }, { + "val" : "BTO:0000404" + }, { + "val" : "CALOHA:TS-0283" + }, { + "val" : "EFO:0000954" + }, { + "val" : "EMAPA:17528" + }, { + "val" : "EV:0100153" + }, { + "val" : "FMA:70596" + }, { + "val" : "GAID:932" + }, { + "val" : "MA:0000153" + }, { + "val" : "MAT:0000154" + }, { + "val" : "MESH:D004817" + }, { + "val" : "MIAA:0000154" + }, { + "val" : "NCIT:C12708" + }, { + "val" : "SCTID:361694003" + }, { + "val" : "TAO:0000105" + }, { + "val" : "VHOG:0000077" + }, { + "val" : "Wikipedia:Epidermis_(skin)" + }, { + "val" : "XAO:0000028" + }, { + "val" : "ZFA:0000105" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001004", + "lbl" : "respiratory system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Functional system which consists of structures involved in respiration.", + "xrefs" : [ "Wikipedia:Respiratory_system", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000541" + }, { + "val" : "BTO:0000203" + }, { + "val" : "CALOHA:TS-1319" + }, { + "val" : "EFO:0000804" + }, { + "val" : "EHDAA2:0001604" + }, { + "val" : "EHDAA:2203" + }, { + "val" : "EMAPA:16727" + }, { + "val" : "EV:0100036" + }, { + "val" : "FMA:7158" + }, { + "val" : "GAID:78" + }, { + "val" : "MA:0000327" + }, { + "val" : "MAT:0000030" + }, { + "val" : "MESH:D012137" + }, { + "val" : "MIAA:0000030" + }, { + "val" : "NCIT:C12779" + }, { + "val" : "SCTID:278197002" + }, { + "val" : "TAO:0000272" + }, { + "val" : "VHOG:0000202" + }, { + "val" : "Wikipedia:Respiratory_system" + }, { + "val" : "XAO:0000117" + }, { + "val" : "ZFA:0000272" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001005", + "lbl" : "respiratory airway", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An airway through which respiratory air passes in organisms.", + "xrefs" : [ "Wikipedia:Trachea" ] + }, + "xrefs" : [ { + "val" : "SCTID:361380005" + }, { + "val" : "Wikipedia:Trachea" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001007", + "lbl" : "digestive system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes.", + "xrefs" : [ "FB:gg", "NLM:alimentary+system", "Wikipedia:Digestive_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0000129" + }, { + "val" : "BILA:0000082" + }, { + "val" : "BTO:0000058" + }, { + "val" : "CALOHA:TS-1293" + }, { + "val" : "EFO:0000793" + }, { + "val" : "FMA:7152" + }, { + "val" : "GAID:278" + }, { + "val" : "MA:0002431" + }, { + "val" : "MAT:0000018" + }, { + "val" : "MESH:D004064" + }, { + "val" : "MIAA:0000018" + }, { + "val" : "SCTID:278859004" + }, { + "val" : "TADS:0000170" + }, { + "val" : "TAO:0000339" + }, { + "val" : "WBbt:0005748" + }, { + "val" : "Wikipedia:Digestive_system" + }, { + "val" : "XAO:0000125" + }, { + "val" : "ZFA:0000339" + }, { + "val" : "galen:DigestiveSystem" + }, { + "val" : "ncithesaurus:Digestive_System" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "lbl" : "renal system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products.", + "xrefs" : [ "DOI:10.1371/journal.pone.0099864", "GO:0072001" ] + }, + "comments" : [ "EDITOR_NOTE In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here" ], + "xrefs" : [ { + "val" : "AAO:0010257" + }, { + "val" : "BILA:0000015" + }, { + "val" : "BTO:0001244" + }, { + "val" : "BTO:0003092" + }, { + "val" : "CALOHA:TS-1323" + }, { + "val" : "EFO:0000803" + }, { + "val" : "EHDAA2:0001601" + }, { + "val" : "EHDAA:5901" + }, { + "val" : "EMAPA:17366" + }, { + "val" : "EV:0100095" + }, { + "val" : "FMA:7159" + }, { + "val" : "GAID:391" + }, { + "val" : "MA:0000325" + }, { + "val" : "MAT:0000027" + }, { + "val" : "MESH:D014551" + }, { + "val" : "MIAA:0000027" + }, { + "val" : "NCIT:C12413" + }, { + "val" : "SCTID:362204003" + }, { + "val" : "TADS:0000162" + }, { + "val" : "TAO:0000163" + }, { + "val" : "VHOG:0000723" + }, { + "val" : "WBbt:0005736" + }, { + "val" : "Wikipedia:Excretory_system" + }, { + "val" : "XAO:0000143" + }, { + "val" : "ZFA:0000163" + }, { + "val" : "galen:UrinaryTract" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001009", + "lbl" : "circulatory system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP].", + "xrefs" : [ "Wikipedia:Circulatory_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0000959" + }, { + "val" : "CALOHA:TS-2103" + }, { + "val" : "VHOG:0001248" + }, { + "val" : "Wikipedia:Circulatory_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001013", + "lbl" : "adipose tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue.", + "xrefs" : [ "MESH:A10.165.114", "MGI:cwg", "MP:0000003", "Wikipedia:Adipose_tissue", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000001" + }, { + "val" : "AEO:000020" + }, { + "val" : "BTO:0001487" + }, { + "val" : "CALOHA:TS-0013" + }, { + "val" : "EFO:0000790" + }, { + "val" : "EHDAA2:0003120" + }, { + "val" : "EMAPA:35112" + }, { + "val" : "EV:0100381" + }, { + "val" : "FMA:20110" + }, { + "val" : "GAID:920" + }, { + "val" : "MA:0000009" + }, { + "val" : "MAT:0000015" + }, { + "val" : "MESH:D000273" + }, { + "val" : "MIAA:0000015" + }, { + "val" : "NCIT:C12472" + }, { + "val" : "SCTID:55603005" + }, { + "val" : "TAO:0002134" + }, { + "val" : "VHOG:0001284" + }, { + "val" : "Wikipedia:Adipose_tissue" + }, { + "val" : "XAO:0003049" + }, { + "val" : "ZFA:0005345" + }, { + "val" : "galen:FattyTissue" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001015", + "lbl" : "musculature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the muscular system corresponding to a subdisivision of an organism.", + "xrefs" : [ "Wikipedia:Muscular_system", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000887" + }, { + "val" : "EFO:0001949" + }, { + "val" : "EMAPA:35577" + }, { + "val" : "FMA:32558" + }, { + "val" : "MA:0000165" + }, { + "val" : "NCIT:C13056" + }, { + "val" : "TAO:0000548" + }, { + "val" : "VSAO:0005038" + }, { + "val" : "WBbt:0005737" + }, { + "val" : "Wikipedia:Muscular_system" + }, { + "val" : "ZFA:0000548" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001016", + "lbl" : "nervous system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].", + "xrefs" : [ "BIRNLEX:844", "ISBN:0-14-051288-8", "ISBN:3110148986", "NLM:nervous+system", "WB:rynl", "Wikipedia:Nervous_system", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0000324" + }, { + "val" : "BILA:0000079" + }, { + "val" : "BIRNLEX:844" + }, { + "val" : "BTO:0001484" + }, { + "val" : "CALOHA:TS-1313" + }, { + "val" : "EFO:0000802" + }, { + "val" : "EHDAA2:0001246" + }, { + "val" : "EHDAA:826" + }, { + "val" : "EMAPA:16469" + }, { + "val" : "EV:0100162" + }, { + "val" : "FMA:7157" + }, { + "val" : "GAID:466" + }, { + "val" : "MA:0000016" + }, { + "val" : "MAT:0000026" + }, { + "val" : "MESH:D009420" + }, { + "val" : "MIAA:0000026" + }, { + "val" : "NCIT:C12755" + }, { + "val" : "SCTID:278196006" + }, { + "val" : "TAO:0000396" + }, { + "val" : "VHOG:0000402" + }, { + "val" : "WBbt:0005735" + }, { + "val" : "Wikipedia:Nervous_system" + }, { + "val" : "XAO:0000177" + }, { + "val" : "ZFA:0000396" + }, { + "val" : "neuronames:3236" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001017", + "lbl" : "central nervous system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.", + "xrefs" : [ "GO:0021551", "http://www.frontiersinzoology.com/content/7/1/29", "https://sourceforge.net/p/geneontology/ontology-requests/11422/" ] + }, + "xrefs" : [ { + "val" : "AAO:0000090" + }, { + "val" : "BAMS:CNS" + }, { + "val" : "BILA:0000080" + }, { + "val" : "BIRNLEX:1099" + }, { + "val" : "BTO:0000227" + }, { + "val" : "CALOHA:TS-0150" + }, { + "val" : "EFO:0000908" + }, { + "val" : "EHDAA2:0000225" + }, { + "val" : "EHDAA:828" + }, { + "val" : "EMAPA:16470" + }, { + "val" : "EMAPA:16754" + }, { + "val" : "EV:0100163" + }, { + "val" : "FMA:55675" + }, { + "val" : "GAID:570" + }, { + "val" : "MA:0000167" + }, { + "val" : "MAT:0000457" + }, { + "val" : "MESH:D002490" + }, { + "val" : "NCIT:C12438" + }, { + "val" : "SCTID:278199004" + }, { + "val" : "TAO:0000012" + }, { + "val" : "VHOG:0000293" + }, { + "val" : "Wikipedia:Central_nervous_system" + }, { + "val" : "XAO:0000215" + }, { + "val" : "ZFA:0000012" + }, { + "val" : "neuronames:854" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001021", + "lbl" : "nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures.", + "xrefs" : [ "FBbt:00005105", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011070" + }, { + "val" : "AEO:0000137" + }, { + "val" : "BAMS:n" + }, { + "val" : "BIRNLEX:1615" + }, { + "val" : "BSA:0000098" + }, { + "val" : "BTO:0000925" + }, { + "val" : "BTO:0001027" + }, { + "val" : "CALOHA:TS-0772" + }, { + "val" : "EHDAA2:0003137" + }, { + "val" : "EHDAA:2851" + }, { + "val" : "EHDAA:3776" + }, { + "val" : "EHDAA:4657" + }, { + "val" : "EMAPA:32808" + }, { + "val" : "EMAPA:32815" + }, { + "val" : "EV:0100371" + }, { + "val" : "FMA:65132" + }, { + "val" : "FMA:65239" + }, { + "val" : "GAID:747" + }, { + "val" : "GAID:758" + }, { + "val" : "MA:0000217" + }, { + "val" : "MA:0000228" + }, { + "val" : "MESH:D010525" + }, { + "val" : "NCIT:C12466" + }, { + "val" : "NCIT:C12768" + }, { + "val" : "NLX:147826" + }, { + "val" : "SCTID:244457007" + }, { + "val" : "SCTID:256864008" + }, { + "val" : "TAO:0007009" + }, { + "val" : "VHOG:0000901" + }, { + "val" : "Wikipedia:Nervous_system" + }, { + "val" : "XAO:0000204" + }, { + "val" : "XAO:0003047" + }, { + "val" : "ZFA:0007009" + }, { + "val" : "galen:Nerve" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001027", + "lbl" : "sensory nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that transmits from sensory receptors on the surface of the body to the central nervous system.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Sensory_nerve" ] + }, + "xrefs" : [ { + "val" : "AEO:0000201" + }, { + "val" : "EHDAA2:0003200" + }, { + "val" : "FMA:5868" + }, { + "val" : "Wikipedia:Sensory_nerve" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001032", + "lbl" : "sensory system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information.", + "xrefs" : [ "Wikipedia:Sensory_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0000555" + }, { + "val" : "BAMS:SEN" + }, { + "val" : "BILA:0000099" + }, { + "val" : "EFO:0000805" + }, { + "val" : "EHDAA2:0003094" + }, { + "val" : "EMAPA:16192" + }, { + "val" : "FMA:75259" + }, { + "val" : "MA:0002442" + }, { + "val" : "MAT:0000031" + }, { + "val" : "MIAA:0000031" + }, { + "val" : "NLXANAT:090816" + }, { + "val" : "TAO:0000282" + }, { + "val" : "VHOG:0001674" + }, { + "val" : "Wikipedia:Sensory_system" + }, { + "val" : "XAO:0003194" + }, { + "val" : "ZFA:0000282" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001040", + "lbl" : "yolk sac", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP].", + "xrefs" : [ "Wikipedia:Yolk_sac" ] + }, + "xrefs" : [ { + "val" : "BTO:0001471" + }, { + "val" : "CALOHA:TS-1130" + }, { + "val" : "EFO:0003078" + }, { + "val" : "EHDAA2:0002212" + }, { + "val" : "EHDAA:164" + }, { + "val" : "EMAPA:16085" + }, { + "val" : "FMA:87180" + }, { + "val" : "GAID:1301" + }, { + "val" : "MESH:D015017" + }, { + "val" : "NCIT:C14128" + }, { + "val" : "SCTID:362845002" + }, { + "val" : "VHOG:0000830" + }, { + "val" : "Wikipedia:Yolk_sac" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001041", + "lbl" : "foregut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anterior subdivision of a digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011042" + }, { + "val" : "BILA:0000085" + }, { + "val" : "BTO:0000507" + }, { + "val" : "EHDAA2:0000557" + }, { + "val" : "EHDAA:520" + }, { + "val" : "EMAPA:16548" + }, { + "val" : "FMA:45616" + }, { + "val" : "MA:0001526" + }, { + "val" : "NCIT:C34180" + }, { + "val" : "SCTID:361409009" + }, { + "val" : "TGMA:0001014" + }, { + "val" : "VHOG:0000285" + }, { + "val" : "Wikipedia:Foregut" + }, { + "val" : "XAO:0000232" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001042", + "lbl" : "chordate pharynx", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED].", + "xrefs" : [ "http://www.feedexp.org" ] + }, + "comments" : [ "Consider generalizing to deuterostome pharynx" ], + "xrefs" : [ { + "val" : "AAO:0000967" + }, { + "val" : "BTO:0001049" + }, { + "val" : "CALOHA:TS-0785" + }, { + "val" : "EFO:0000836" + }, { + "val" : "EHDAA2:0001458" + }, { + "val" : "EHDAA:2947" + }, { + "val" : "EMAPA:16706" + }, { + "val" : "EV:0100065" + }, { + "val" : "FMA:46688" + }, { + "val" : "GAID:155" + }, { + "val" : "MA:0000432" + }, { + "val" : "MESH:D010614" + }, { + "val" : "NCIT:C12425" + }, { + "val" : "SCTID:181211006" + }, { + "val" : "TAO:0000056" + }, { + "val" : "VHOG:0000462" + }, { + "val" : "Wikipedia:Pharynx" + }, { + "val" : "XAO:0003227" + }, { + "val" : "ZFA:0000056" + }, { + "val" : "galen:Pharynx" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001043", + "lbl" : "esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).", + "xrefs" : [ "Wikipedia:Esophagus", "http://www.rivm.nl/interspeciesinfo/inter/oesophagus/" ] + }, + "xrefs" : [ { + "val" : "AAO:0000145" + }, { + "val" : "ANISEED:1235301" + }, { + "val" : "BTO:0000959" + }, { + "val" : "CALOHA:TS-0700" + }, { + "val" : "EFO:0000835" + }, { + "val" : "EHDAA2:0001285" + }, { + "val" : "EHDAA:2937" + }, { + "val" : "EMAPA:16833" + }, { + "val" : "EV:0100069" + }, { + "val" : "FMA:7131" + }, { + "val" : "GAID:291" + }, { + "val" : "MA:0000352" + }, { + "val" : "MAT:0000048" + }, { + "val" : "MESH:D004947" + }, { + "val" : "MIAA:0000048" + }, { + "val" : "NCIT:C12389" + }, { + "val" : "SCTID:181245004" + }, { + "val" : "TAO:0000204" + }, { + "val" : "VHOG:0000450" + }, { + "val" : "Wikipedia:Esophagus" + }, { + "val" : "XAO:0000127" + }, { + "val" : "ZFA:0000204" + }, { + "val" : "galen:Esophagus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001045", + "lbl" : "midgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO].", + "xrefs" : [ "GO:0007494", "Wikipedia:Midgut" ] + }, + "xrefs" : [ { + "val" : "BILA:0000086" + }, { + "val" : "BTO:0000863" + }, { + "val" : "EFO:0001950" + }, { + "val" : "EHDAA2:0001185" + }, { + "val" : "EHDAA:983" + }, { + "val" : "EMAPA:16255" + }, { + "val" : "FMA:45617" + }, { + "val" : "MA:0001564" + }, { + "val" : "NCIT:C34210" + }, { + "val" : "SCTID:361410004" + }, { + "val" : "TGMA:0001036" + }, { + "val" : "VHOG:0000290" + }, { + "val" : "Wikipedia:Midgut" + }, { + "val" : "XAO:0000103" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001046", + "lbl" : "hindgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The caudalmost subdivision of a digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011052" + }, { + "val" : "BILA:0000087" + }, { + "val" : "BTO:0000510" + }, { + "val" : "EHDAA2:0000779" + }, { + "val" : "EHDAA:975" + }, { + "val" : "EMAPA:16715" + }, { + "val" : "FMA:45618" + }, { + "val" : "MA:0001527" + }, { + "val" : "NCIT:C34188" + }, { + "val" : "SCTID:362856002" + }, { + "val" : "TGMA:0001020" + }, { + "val" : "VHOG:0000459" + }, { + "val" : "Wikipedia:Hindgut" + }, { + "val" : "XAO:0000104" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001048", + "lbl" : "primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)].", + "xrefs" : [ "BTO:0001886", "FB:DJS", "FB:FBrf0089570", "http://flybase.org/reports/FBrf0178740.html" ] + }, + "xrefs" : [ { + "val" : "AEO:0000171" + }, { + "val" : "BTO:0001886" + }, { + "val" : "EFO:0001652" + }, { + "val" : "EHDAA2:0003171" + }, { + "val" : "FMA:86589" + }, { + "val" : "MAT:0000482" + }, { + "val" : "NCIT:C34275" + }, { + "val" : "Wikipedia:Primordium" + }, { + "val" : "XAO:0003043" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001049", + "lbl" : "neural tube", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Neural_tube" ] + }, + "xrefs" : [ { + "val" : "AAO:0010617" + }, { + "val" : "BTO:0001057" + }, { + "val" : "CALOHA:TS-2371" + }, { + "val" : "DHBA:10154" + }, { + "val" : "EHDAA2:0001254" + }, { + "val" : "EHDAA:2869" + }, { + "val" : "EHDAA:908" + }, { + "val" : "EMAPA:16164" + }, { + "val" : "EMAPA:16757" + }, { + "val" : "FMA:293882" + }, { + "val" : "MAT:0000069" + }, { + "val" : "MIAA:0000069" + }, { + "val" : "NCIT:C34226" + }, { + "val" : "SCTID:362852000" + }, { + "val" : "TAO:0001135" + }, { + "val" : "VHOG:0000307" + }, { + "val" : "Wikipedia:Neural_tube" + }, { + "val" : "XAO:0003204" + }, { + "val" : "ZFA:0001135" + }, { + "val" : "neuronames:1365" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "lbl" : "rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The terminal portion of the intestinal tube, terminating with the anus.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0000492", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010401" + }, { + "val" : "BTO:0001158" + }, { + "val" : "CALOHA:TS-1180" + }, { + "val" : "EFO:0000848" + }, { + "val" : "EHDAA2:0001592" + }, { + "val" : "EHDAA:5836" + }, { + "val" : "EMAPA:17896" + }, { + "val" : "EV:0100081" + }, { + "val" : "FMA:14544" + }, { + "val" : "GAID:311" + }, { + "val" : "MA:0000336" + }, { + "val" : "MAT:0000050" + }, { + "val" : "MESH:D012007" + }, { + "val" : "MIAA:0000050" + }, { + "val" : "NCIT:C12390" + }, { + "val" : "SCTID:181261002" + }, { + "val" : "VHOG:0001751" + }, { + "val" : "Wikipedia:Rectum" + }, { + "val" : "XAO:0000238" + }, { + "val" : "galen:Rectum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001062", + "lbl" : "anatomical entity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.", + "xrefs" : [ "FMA:62955", "http://orcid.org/0000-0001-9114-8737" ] + }, + "xrefs" : [ { + "val" : "AAO:0010841" + }, { + "val" : "AEO:0000000" + }, { + "val" : "BFO:0000004" + }, { + "val" : "BILA:0000000" + }, { + "val" : "BIRNLEX:6" + }, { + "val" : "CARO:0000000" + }, { + "val" : "EHDAA2:0002229" + }, { + "val" : "FMA:62955" + }, { + "val" : "HAO:0000000" + }, { + "val" : "MA:0000001" + }, { + "val" : "NCIT:C12219" + }, { + "val" : "TAO:0100000" + }, { + "val" : "TGMA:0001822" + }, { + "val" : "WBbt:0000100" + }, { + "val" : "XAO:0000000" + }, { + "val" : "ZFA:0100000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "lbl" : "ventral pancreatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla.", + "xrefs" : [ "Wikipedia:Pancreatic_duct" ] + }, + "comments" : [ "EDITOR_NOTE in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue" ], + "xrefs" : [ { + "val" : "BTO:0002362" + }, { + "val" : "EHDAA2:0001396" + }, { + "val" : "EHDAA:6905" + }, { + "val" : "EMAPA:17510" + }, { + "val" : "FMA:16003" + }, { + "val" : "GAID:337" + }, { + "val" : "MA:0000126" + }, { + "val" : "MESH:D010183" + }, { + "val" : "NCIT:C12272" + }, { + "val" : "RETIRED_EHDAA2:0002177" + }, { + "val" : "SCTID:245385001" + }, { + "val" : "VHOG:0000256" + }, { + "val" : "Wikipedia:Pancreatic_duct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001068", + "lbl" : "skin of back", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region" ], + "xrefs" : [ { + "val" : "EMAPA:36392" + }, { + "val" : "FMA:10462" + }, { + "val" : "FMA:22985" + }, { + "val" : "MA:0000498" + }, { + "val" : "SCTID:181492002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001070", + "lbl" : "external carotid artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP].", + "xrefs" : [ "MGI:anna" ] + }, + "xrefs" : [ { + "val" : "AAO:0010218" + }, { + "val" : "AAO:0010416" + }, { + "val" : "BTO:0004696" + }, { + "val" : "EFO:0001953" + }, { + "val" : "EHDAA2:0000461" + }, { + "val" : "EMAPA:18611" + }, { + "val" : "FMA:10635" + }, { + "val" : "GAID:480" + }, { + "val" : "MA:0001929" + }, { + "val" : "MESH:D002342" + }, { + "val" : "NCIT:C32551" + }, { + "val" : "SCTID:362044002" + }, { + "val" : "VHOG:0000265" + }, { + "val" : "Wikipedia:External_carotid_artery" + }, { + "val" : "XAO:0000345" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001071", + "lbl" : "superficial cervical artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery.", + "xrefs" : [ "Wikipedia:Superficial_part_of_transverse_cervical_artery" ] + }, + "comments" : [ "The transverse cervical artery splits into two branches, a superficial one and a deep one[WP]" ], + "xrefs" : [ { + "val" : "FMA:10665" + }, { + "val" : "MA:0002052" + }, { + "val" : "NCIT:C53005" + }, { + "val" : "SCTID:161746006" + }, { + "val" : "Wikipedia:Superficial_part_of_transverse_cervical_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001072", + "lbl" : "inferior vena cava", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart.", + "xrefs" : [ "Wikipedia:Inferior_vena_cava", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011083" + }, { + "val" : "BTO:0002682" + }, { + "val" : "EHDAA2:0000611" + }, { + "val" : "EMAPA:18416" + }, { + "val" : "FMA:10951" + }, { + "val" : "GAID:548" + }, { + "val" : "MA:0000480" + }, { + "val" : "MESH:D014682" + }, { + "val" : "NCIT:C12815" + }, { + "val" : "SCTID:181369003" + }, { + "val" : "VHOG:0001194" + }, { + "val" : "Wikipedia:Inferior_vena_cava" + }, { + "val" : "XAO:0000388" + }, { + "val" : "galen:InferiorVenaCava" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "lbl" : "ileocecal junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice.", + "xrefs" : [ "http://www.medilexicon.com/medicaldictionary.php?t=46539" ] + }, + "xrefs" : [ { + "val" : "FMA:11338" + }, { + "val" : "MA:0000332" + }, { + "val" : "SCTID:264021000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001074", + "lbl" : "pericardial cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A potential space between the visceral and parietal layers of the pericardium.", + "xrefs" : [ "Wikipedia:Pericardium" ] + }, + "xrefs" : [ { + "val" : "BSA:0000091" + }, { + "val" : "EHDAA2:0001434" + }, { + "val" : "EMAPA:16131" + }, { + "val" : "EMAPA:16132" + }, { + "val" : "FMA:11350" + }, { + "val" : "MA:0000053" + }, { + "val" : "NCIT:C38662" + }, { + "val" : "SCTID:362027001" + }, { + "val" : "TAO:0002220" + }, { + "val" : "VHOG:0000556" + }, { + "val" : "Wikipedia:Pericardial_cavity" + }, { + "val" : "ZFA:0001655" + }, { + "val" : "galen:PericardialSpace" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001081", + "lbl" : "endocardium of ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endocardium that is part of the cardiac ventricle.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32747" + }, { + "val" : "FMA:12148" + }, { + "val" : "MA:0000079" + }, { + "val" : "SCTID:192172004" + }, { + "val" : "TAO:0002247" + }, { + "val" : "VHOG:0000607" + }, { + "val" : "ZFA:0001615" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001082", + "lbl" : "epicardium of ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epicardial layer that lines a cardiac ventricle.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:12150" + }, { + "val" : "TAO:0005058" + }, { + "val" : "ZFA:0005058" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001083", + "lbl" : "myocardium of ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EFO:0003088" + }, { + "val" : "EMAPA:32748" + }, { + "val" : "FMA:12151" + }, { + "val" : "MA:0000082" + }, { + "val" : "SCTID:192084000" + }, { + "val" : "TAO:0005061" + }, { + "val" : "VHOG:0000604" + }, { + "val" : "ZFA:0005061" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001084", + "lbl" : "skin of head", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region" ], + "xrefs" : [ { + "val" : "FMA:12166" + }, { + "val" : "FMA:24756" + }, { + "val" : "MA:0000582" + }, { + "val" : "NCIT:C52757" + }, { + "val" : "SCTID:181484006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001085", + "lbl" : "skin of trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region" ], + "xrefs" : [ { + "val" : "FMA:12167" + }, { + "val" : "FMA:23093" + }, { + "val" : "MA:0000517" + }, { + "val" : "NCIT:C12295" + }, { + "val" : "SCTID:181489001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001087", + "lbl" : "pleural fluid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Transudate contained in the pleural cavity.", + "xrefs" : [ "FMA:12273" ] + }, + "xrefs" : [ { + "val" : "BTO:0003080" + }, { + "val" : "FMA:12273" + }, { + "val" : "MA:0002532" + }, { + "val" : "MAT:0000500" + }, { + "val" : "Wikipedia:Pleural_fluid" + }, { + "val" : "ncithesaurus:Pleural_Fluid" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001090", + "lbl" : "synovial fluid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Joint fluid is a transudate of plasma that is actively secreted by synovial cells.", + "xrefs" : [ "https://www.ncbi.nlm.nih.gov/books/NBK274/" ] + }, + "xrefs" : [ { + "val" : "BTO:0001339" + }, { + "val" : "CALOHA:TS-0996" + }, { + "val" : "ENVO:02000039" + }, { + "val" : "FMA:12277" + }, { + "val" : "GAID:265" + }, { + "val" : "MA:0002544" + }, { + "val" : "MESH:D013582" + }, { + "val" : "NCIT:C33718" + }, { + "val" : "TAO:0005154" + }, { + "val" : "Wikipedia:Synovial_fluid" + }, { + "val" : "ZFA:0005154" + }, { + "val" : "galen:SynovialFluid" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001092", + "lbl" : "vertebral bone 1", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first vertebral bone in the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000709" + }, { + "val" : "EHDAA:10606" + }, { + "val" : "EMAPA:19431" + }, { + "val" : "FMA:12519" + }, { + "val" : "GAID:236" + }, { + "val" : "MA:0001421" + }, { + "val" : "MESH:D001270" + }, { + "val" : "NCIT:C32239" + }, { + "val" : "SCTID:181818007" + }, { + "val" : "TAO:0001167" + }, { + "val" : "Wikipedia:Atlas_(anatomy)" + }, { + "val" : "ZFA:0001167" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001093", + "lbl" : "vertebral bone 2", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The second vertebral bone in the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA:10608" + }, { + "val" : "EMAPA:19432" + }, { + "val" : "FMA:12520" + }, { + "val" : "GAID:237" + }, { + "val" : "MA:0001422" + }, { + "val" : "MESH:D001368" + }, { + "val" : "NCIT:C32240" + }, { + "val" : "SCTID:181819004" + }, { + "val" : "TAO:0001168" + }, { + "val" : "Wikipedia:Axis_(anatomy)" + }, { + "val" : "ZFA:0001168" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001095", + "lbl" : "caudal vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Taxon notes In zebrafish, Vertebra bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae" ], + "xrefs" : [ { + "val" : "EMAPA:18374" + }, { + "val" : "FMA:12527" + }, { + "val" : "MA:0000310" + }, { + "val" : "MA:0001420" + }, { + "val" : "NCIT:C32334" + }, { + "val" : "SCTID:361774004" + }, { + "val" : "TAO:0000326" + }, { + "val" : "Wikipedia:Caudal_vertebra" + }, { + "val" : "XAO:0003079" + }, { + "val" : "ZFA:0000326" + }, { + "val" : "galen:CoccygealVertebra" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001096", + "lbl" : "wall of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35326" + }, { + "val" : "FMA:12611" + }, { + "val" : "MA:0002691" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001103", + "lbl" : "diaphragm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control.", + "xrefs" : [ "MP:0002279" ] + }, + "xrefs" : [ { + "val" : "BTO:0000341" + }, { + "val" : "CALOHA:TS-0198" + }, { + "val" : "EFO:0000937" + }, { + "val" : "EHDAA2:0003495" + }, { + "val" : "EMAPA:17701" + }, { + "val" : "EV:0100376" + }, { + "val" : "FMA:13295" + }, { + "val" : "GAID:158" + }, { + "val" : "MA:0001904" + }, { + "val" : "MAT:0000502" + }, { + "val" : "MESH:D003964" + }, { + "val" : "NCIT:C12702" + }, { + "val" : "SCTID:181614006" + }, { + "val" : "VHOG:0000713" + }, { + "val" : "Wikipedia:Thoracid_diaphragm" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001113", + "lbl" : "lobe of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe.", + "xrefs" : [ "Wikipedia:Liver#Lobes" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18306" + }, { + "val" : "FMA:13361" + }, { + "val" : "MA:0000360" + }, { + "val" : "NCIT:C49579" + }, { + "val" : "SCTID:245378000" + }, { + "val" : "Wikipedia:Liver#Lobes" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001114", + "lbl" : "right lobe of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Right_lobe_of_liver" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001008" + }, { + "val" : "EHDAA:4001" + }, { + "val" : "EMAPA:18311" + }, { + "val" : "FMA:13362" + }, { + "val" : "MA:0000363" + }, { + "val" : "NCIT:C33481" + }, { + "val" : "SCTID:362182008" + }, { + "val" : "TAO:0005173" + }, { + "val" : "VHOG:0001424" + }, { + "val" : "Wikipedia:Right_lobe_of_liver" + }, { + "val" : "ZFA:0005173" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001115", + "lbl" : "left lobe of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Left_lobe_of_liver" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001000" + }, { + "val" : "EHDAA:3995" + }, { + "val" : "EMAPA:18307" + }, { + "val" : "FMA:13363" + }, { + "val" : "MA:0000361" + }, { + "val" : "NCIT:C32965" + }, { + "val" : "SCTID:362183003" + }, { + "val" : "TAO:0005172" + }, { + "val" : "VHOG:0001423" + }, { + "val" : "Wikipedia:Left_lobe_of_liver" + }, { + "val" : "ZFA:0005172" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "lbl" : "vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO].", + "xrefs" : [ "VSAO:0000185", "https://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/tracker/?func=detail&aid=3530322&group_id=76834&atid=2257941" ] + }, + "xrefs" : [ { + "val" : "AAO:0000699" + }, { + "val" : "AAO:0000734" + }, { + "val" : "BTO:0000818" + }, { + "val" : "EFO:0001369" + }, { + "val" : "EHDA:10119" + }, { + "val" : "EMAPA:35919" + }, { + "val" : "FMA:13478" + }, { + "val" : "GAID:106" + }, { + "val" : "MA:0002416" + }, { + "val" : "MESH:D013131" + }, { + "val" : "NCIT:C12998" + }, { + "val" : "NCIT:C33588" + }, { + "val" : "NIF_Subcellular:sao1145756102" + }, { + "val" : "SCTID:44300000" + }, { + "val" : "TAO:0001559" + }, { + "val" : "VHOG:0001142" + }, { + "val" : "VSAO:0000185" + }, { + "val" : "Wikipedia:Vertebral_column" + }, { + "val" : "XAO:0003074" + }, { + "val" : "ZFA:0001559" + }, { + "val" : "galen:SpinalColumn" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001133", + "lbl" : "cardiac muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified].", + "xrefs" : [ "ZFA:0005280" ] + }, + "xrefs" : [ { + "val" : "AAO:0010245" + }, { + "val" : "AEO:0000142" + }, { + "val" : "BILA:0000134" + }, { + "val" : "BTO:0000199" + }, { + "val" : "CALOHA:TS-0440" + }, { + "val" : "EHDAA2:0003142" + }, { + "val" : "EMAPA:32688" + }, { + "val" : "FMA:14068" + }, { + "val" : "TAO:0005280" + }, { + "val" : "Wikipedia:Cardiac_muscle" + }, { + "val" : "ZFA:0005280" + }, { + "val" : "galen:CardiacMuscle" + }, { + "val" : "galen:CardiacMuscleTissue" + }, { + "val" : "ncithesaurus:Heart_Muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001134", + "lbl" : "skeletal muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle tissue that consists primarily of skeletal muscle fibers.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/324" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32716" + }, { + "val" : "FMA:14069" + }, { + "val" : "MA:0002439" + }, { + "val" : "NCIT:C13050" + }, { + "val" : "SCTID:426215008" + }, { + "val" : "Wikipedia:Skeletal_striated_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001135", + "lbl" : "smooth muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO].", + "xrefs" : [ "GO:0006939", "Wikipedia:Smooth_muscle_tissue" ] + }, + "xrefs" : [ { + "val" : "AAO:0010244" + }, { + "val" : "AEO:0000141" + }, { + "val" : "BTO:0001260" + }, { + "val" : "CALOHA:TS-0943" + }, { + "val" : "EFO:0000889" + }, { + "val" : "EHDAA2:0003141" + }, { + "val" : "EMAPA:32717" + }, { + "val" : "EV:0100378" + }, { + "val" : "FMA:14070" + }, { + "val" : "GAID:167" + }, { + "val" : "MA:0000166" + }, { + "val" : "MAT:0000303" + }, { + "val" : "MESH:D009130" + }, { + "val" : "MIAA:0000303" + }, { + "val" : "NCIT:C12437" + }, { + "val" : "TAO:0005274" + }, { + "val" : "VHOG:0001246" + }, { + "val" : "WBbt:0005781" + }, { + "val" : "Wikipedia:Smooth_muscle_tissue" + }, { + "val" : "XAO:0000175" + }, { + "val" : "ZFA:0005274" + }, { + "val" : "galen:SmoothMuscle" + }, { + "val" : "galen:SmoothMuscleTissue" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001136", + "lbl" : "mesothelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri).", + "xrefs" : [ "FMA:14074", "Wikipedia:Mesothelium" ] + }, + "xrefs" : [ { + "val" : "AEO:0000111" + }, { + "val" : "BTO:0002422" + }, { + "val" : "CALOHA:TS-1183" + }, { + "val" : "EHDAA2_RETIRED:0003111" + }, { + "val" : "EHDAA:2331" + }, { + "val" : "EHDAA:2349" + }, { + "val" : "EHDAA:295" + }, { + "val" : "EHDAA:6073" + }, { + "val" : "EHDAA:640" + }, { + "val" : "EHDAA:646" + }, { + "val" : "EMAPA:32856" + }, { + "val" : "FMA:14074" + }, { + "val" : "MA:0000565" + }, { + "val" : "NCIT:C33105" + }, { + "val" : "SCTID:361918002" + }, { + "val" : "Wikipedia:Mesothelium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001137", + "lbl" : "dorsum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column..", + "xrefs" : [ "BSPO:0000063", "UBERONREF:0000006", "Wikipedia:Dorsum_(anatomy)" ] + }, + "xrefs" : [ { + "val" : "BTO:0001713" + }, { + "val" : "CALOHA:TS-2223" + }, { + "val" : "EFO:0001405" + }, { + "val" : "FMA:14181" + }, { + "val" : "GAID:30" + }, { + "val" : "MESH:D001415" + }, { + "val" : "NCIT:C13062" + }, { + "val" : "SCTID:123961009" + }, { + "val" : "Wikipedia:Dorsum_(anatomy)" + }, { + "val" : "galen:Back" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "lbl" : "superior mesenteric vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Superior_mesenteric_vein" ] + }, + "xrefs" : [ { + "val" : "BTO:0002783" + }, { + "val" : "EHDAA2:0001951" + }, { + "val" : "EHDAA:5414" + }, { + "val" : "EMAPA:18643" + }, { + "val" : "FMA:14332" + }, { + "val" : "MA:0002179" + }, { + "val" : "NCIT:C33687" + }, { + "val" : "SCTID:278031001" + }, { + "val" : "VHOG:0000552" + }, { + "val" : "Wikipedia:Superior_mesenteric_vein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "lbl" : "hepatic vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vein that carries blood away from the liver[ZFA].", + "xrefs" : [ "Wikipedia:Hepatic_vein", "ZFA:0000670", "https://sourceforge.net/tracker/?func=detail&aid=3565355&group_id=76834&atid=1205376" ] + }, + "xrefs" : [ { + "val" : "AAO:0010216" + }, { + "val" : "EMAPA:19221" + }, { + "val" : "FMA:14337" + }, { + "val" : "GAID:534" + }, { + "val" : "MA:0003015" + }, { + "val" : "MESH:D006503" + }, { + "val" : "NCIT:C32736" + }, { + "val" : "SCTID:278191001" + }, { + "val" : "TAO:0000670" + }, { + "val" : "Wikipedia:Hepatic_vein" + }, { + "val" : "XAO:0000387" + }, { + "val" : "ZFA:0000670" + }, { + "val" : "galen:HepaticVein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001145", + "lbl" : "ovarian vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries.", + "xrefs" : [ "Wikipedia:Ovarian_vein" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18644" + }, { + "val" : "FMA:14346" + }, { + "val" : "MA:0002186" + }, { + "val" : "NCIT:C53058" + }, { + "val" : "SCTID:278193003" + }, { + "val" : "Wikipedia:Ovarian_vein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "lbl" : "cystic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0009493" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000333" + }, { + "val" : "EHDAA:3045" + }, { + "val" : "EMAPA:16841" + }, { + "val" : "FMA:14539" + }, { + "val" : "GAID:290" + }, { + "val" : "MA:0000355" + }, { + "val" : "MESH:D003549" + }, { + "val" : "NCIT:C32421" + }, { + "val" : "SCTID:245398005" + }, { + "val" : "TAO:0005166" + }, { + "val" : "VHOG:0000213" + }, { + "val" : "Wikipedia:Cystic_duct" + }, { + "val" : "ZFA:0005166" + }, { + "val" : "galen:CysticDuct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001155", + "lbl" : "colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal.", + "xrefs" : [ "Wikipedia:Colon_(anatomy)", "ZFIN:curator", "http://orcid.org/0000-0002-2825-0621", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010400" + }, { + "val" : "BTO:0000269" + }, { + "val" : "CALOHA:TS-0158" + }, { + "val" : "EFO:0000361" + }, { + "val" : "EMAPA:18939" + }, { + "val" : "EV:0100079" + }, { + "val" : "FMA:14543" + }, { + "val" : "GAID:309" + }, { + "val" : "MA:0000335" + }, { + "val" : "MAP:0000001" + }, { + "val" : "MAT:0000526" + }, { + "val" : "MESH:D003106" + }, { + "val" : "NCIT:C12382" + }, { + "val" : "SCTID:302508007" + }, { + "val" : "TAO:0000706" + }, { + "val" : "VHOG:0000648" + }, { + "val" : "Wikipedia:Colon_(anatomy)" + }, { + "val" : "XAO:0000243" + }, { + "val" : "ZFA:0000706" + }, { + "val" : "galen:Colon" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001159", + "lbl" : "sigmoid colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity.", + "xrefs" : [ "Wikipedia:Sigmoid_colon" ] + }, + "xrefs" : [ { + "val" : "BTO:0000645" + }, { + "val" : "CALOHA:TS-2044" + }, { + "val" : "EFO:0000846" + }, { + "val" : "EMAPA:36391" + }, { + "val" : "FMA:14548" + }, { + "val" : "MAT:0000314" + }, { + "val" : "MESH:D012809" + }, { + "val" : "MIAA:0000314" + }, { + "val" : "NCIT:C12384" + }, { + "val" : "NCIT:C33550" + }, { + "val" : "SCTID:362166007" + }, { + "val" : "Wikipedia:Sigmoid_colon" + }, { + "val" : "galen:SigmoidColon" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001161", + "lbl" : "body of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO].", + "xrefs" : [ "GO:0014845", "Wikipedia:Body_of_stomach" ] + }, + "xrefs" : [ { + "val" : "BTO:0000505" + }, { + "val" : "EMAPA:35810" + }, { + "val" : "FMA:14560" + }, { + "val" : "MA:0002559" + }, { + "val" : "NCIT:C12258" + }, { + "val" : "SCTID:362140009" + }, { + "val" : "Wikipedia:Body_of_stomach" + }, { + "val" : "galen:GastricCorpus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "lbl" : "pyloric antrum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010790" ] + }, + "xrefs" : [ { + "val" : "BTO:0001732" + }, { + "val" : "EFO:0002555" + }, { + "val" : "EMAPA:17891" + }, { + "val" : "FMA:14579" + }, { + "val" : "GAID:332" + }, { + "val" : "MA:0001624" + }, { + "val" : "MESH:D011706" + }, { + "val" : "NCIT:C12259" + }, { + "val" : "SCTID:362142001" + }, { + "val" : "Wikipedia:Pyloric_antrum" + }, { + "val" : "galen:PyloricAntrum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "lbl" : "pylorus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum.", + "xrefs" : [ "MGI:csmith", "MP:0010785" ] + }, + "xrefs" : [ { + "val" : "BTO:0001146" + }, { + "val" : "EHDAA2:0001580" + }, { + "val" : "EHDAA:4860" + }, { + "val" : "EMAPA:17631" + }, { + "val" : "FMA:14581" + }, { + "val" : "GAID:333" + }, { + "val" : "MA:0002560" + }, { + "val" : "MESH:D011708" + }, { + "val" : "NCIT:C12260" + }, { + "val" : "SCTID:362143006" + }, { + "val" : "VHOG:0000420" + }, { + "val" : "Wikipedia:Pylorus" + }, { + "val" : "galen:Pylorus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001167", + "lbl" : "wall of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between.", + "xrefs" : [ "MGI:csmith", "MP:0010783" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35826" + }, { + "val" : "FMA:14582" + }, { + "val" : "MA:0002692" + }, { + "val" : "SCTID:279995000" + }, { + "val" : "galen:WallOfStomach" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001168", + "lbl" : "wall of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of a small intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35785" + }, { + "val" : "FMA:14615" + }, { + "val" : "MA:0002696" + }, { + "val" : "NCIT:C33573" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001169", + "lbl" : "wall of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35470" + }, { + "val" : "FMA:14619" + }, { + "val" : "MA:0002695" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001170", + "lbl" : "mesentery of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP].", + "xrefs" : [ "Wikipedia:Mesentery#Mesentery_.28proper.29" ] + }, + "xrefs" : [ { + "val" : "FMA:14643" + }, { + "val" : "MA:0001555" + }, { + "val" : "SCTID:245456008" + }, { + "val" : "Wikipedia:Mesentery#Mesentery_.28proper.29" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001171", + "lbl" : "portal lobule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel.", + "xrefs" : [ "MP:0008992" ] + }, + "xrefs" : [ { + "val" : "FMA:14653" + }, { + "val" : "MA:0002498" + }, { + "val" : "NCIT:C33341" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "lbl" : "hepatic acinus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_acinus.html" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35497" + }, { + "val" : "FMA:14654" + }, { + "val" : "MA:0002496" + }, { + "val" : "NCIT:C32992" + }, { + "val" : "SCTID:272214009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "lbl" : "biliary tree", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder.", + "xrefs" : [ "DOI:10.1002/ar.20664" ] + }, + "comments" : [ "The path in many species is as follows: Bile canaliculi -> Canals of Hering (intralobar bile duct) -> interlobular bile ducts -> intrahepatic bile ducts -> left and right hepatic ducts merge to form -> common hepatic duct *exits liver* and joins -> cystic duct (from gall bladder) forming -> common bile duct -> joins with pancreatic duct -> forming ampulla of Vater -> enters duodenum [WP]" ], + "xrefs" : [ { + "val" : "AAO:0011020" + }, { + "val" : "EMAPA:35172" + }, { + "val" : "FMA:14665" + }, { + "val" : "SCTID:181267003" + }, { + "val" : "Wikipedia:Biliary_tract" + }, { + "val" : "XAO:0000455" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001174", + "lbl" : "common bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct.", + "xrefs" : [ "MGI:csmith", "MP:0009495" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000303" + }, { + "val" : "EHDAA:3981" + }, { + "val" : "EMAPA:17201" + }, { + "val" : "FMA:14667" + }, { + "val" : "GAID:282" + }, { + "val" : "MA:0001631" + }, { + "val" : "MESH:D003135" + }, { + "val" : "NCIT:C12698" + }, { + "val" : "SCTID:362199009" + }, { + "val" : "TAO:0005165" + }, { + "val" : "VHOG:0000214" + }, { + "val" : "Wikipedia:Common_bile_duct" + }, { + "val" : "ZFA:0005165" + }, { + "val" : "galen:CommonBileDuct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "lbl" : "common hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP].", + "xrefs" : [ "Wikipedia:Common_hepatic_duct", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19101" + }, { + "val" : "FMA:14668" + }, { + "val" : "GAID:286" + }, { + "val" : "MA:0002660" + }, { + "val" : "MESH:D006500" + }, { + "val" : "NCIT:C32356" + }, { + "val" : "SCTID:245403006" + }, { + "val" : "VHOG:0000220" + }, { + "val" : "Wikipedia:Common_hepatic_duct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001176", + "lbl" : "right hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct.", + "xrefs" : [ "http://www.medterms.com/script/main/art.asp?articlekey=26034" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001727" + }, { + "val" : "EHDAA:3992" + }, { + "val" : "EMAPA:32797" + }, { + "val" : "FMA:14669" + }, { + "val" : "MA:0001639" + }, { + "val" : "NCIT:C33476" + }, { + "val" : "SCTID:245401008" + }, { + "val" : "VHOG:0000217" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001177", + "lbl" : "left hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct.", + "xrefs" : [ "http://www.medterms.com/script/main/art.asp?articlekey=26035" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000941" + }, { + "val" : "EHDAA:3990" + }, { + "val" : "EMAPA:32795" + }, { + "val" : "FMA:14670" + }, { + "val" : "MA:0001638" + }, { + "val" : "NCIT:C32960" + }, { + "val" : "SCTID:245400009" + }, { + "val" : "VHOG:0000218" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001178", + "lbl" : "visceral peritoneum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space.", + "xrefs" : [ "Wikipedia:Peritoneum#Types", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16592" + }, { + "val" : "FMA:14703" + }, { + "val" : "SCTID:362702003" + }, { + "val" : "TAO:0005132" + }, { + "val" : "VHOG:0001528" + }, { + "val" : "Wikipedia:Visceral_peritoneum" + }, { + "val" : "ZFA:0005132" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001179", + "lbl" : "peritoneal cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cavity bounded by visceral and parietal peritoneum.", + "xrefs" : [ "Wikipedia:Peritoneal_cavity", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "BTO:0001782" + }, { + "val" : "EHDAA2:0001446" + }, { + "val" : "EMAPA:16138" + }, { + "val" : "FMA:14704" + }, { + "val" : "GAID:24" + }, { + "val" : "MA:0000054" + }, { + "val" : "MESH:D010529" + }, { + "val" : "NCIT:C12769" + }, { + "val" : "SCTID:181616008" + }, { + "val" : "VHOG:0000852" + }, { + "val" : "Wikipedia:Peritoneal_cavity" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001190", + "lbl" : "ovarian artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that supplies an ovary.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18620" + }, { + "val" : "FMA:14761" + }, { + "val" : "MA:0002012" + }, { + "val" : "NCIT:C33242" + }, { + "val" : "SCTID:244280002" + }, { + "val" : "Wikipedia:Ovarian_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001193", + "lbl" : "hepatic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that supplies the liver.", + "xrefs" : [ "Wikipedia:Hepatic_artery_proper", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004307" + }, { + "val" : "EMAPA:17859" + }, { + "val" : "FMA:14769" + }, { + "val" : "GAID:496" + }, { + "val" : "MA:0001963" + }, { + "val" : "MESH:D006499" + }, { + "val" : "NCIT:C32729" + }, { + "val" : "SCTID:76015000" + }, { + "val" : "TAO:0005161" + }, { + "val" : "ZFA:0005161" + }, { + "val" : "galen:HepaticArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001194", + "lbl" : "splenic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that supplies the spleen.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19216" + }, { + "val" : "FMA:14773" + }, { + "val" : "GAID:510" + }, { + "val" : "MA:0001991" + }, { + "val" : "MA:0003177" + }, { + "val" : "MESH:D013157" + }, { + "val" : "NCIT:C33597" + }, { + "val" : "SCTID:244266009" + }, { + "val" : "Wikipedia:Splenic_artery" + }, { + "val" : "galen:SplenicArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001199", + "lbl" : "mucosa of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The mucosal layer that lines the stomach.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001308" + }, { + "val" : "CALOHA:TS-0404" + }, { + "val" : "EMAPA:35817" + }, { + "val" : "FMA:14907" + }, { + "val" : "GAID:321" + }, { + "val" : "MA:0002683" + }, { + "val" : "MESH:D005753" + }, { + "val" : "NCIT:C32656" + }, { + "val" : "SCTID:362131005" + }, { + "val" : "Wikipedia:Gastric_mucosa" + }, { + "val" : "galen:GastricMucosa" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001200", + "lbl" : "submucosa of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The fibrous connective tissue layer beneath the stomach mucosa.", + "xrefs" : [ "MGI:csmith", "MP:0010794" ] + }, + "xrefs" : [ { + "val" : "BTO:0002110" + }, { + "val" : "EMAPA:35825" + }, { + "val" : "FMA:14908" + }, { + "val" : "MA:0002685" + }, { + "val" : "NCIT:C32663" + }, { + "val" : "SCTID:52459002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001201", + "lbl" : "serosa of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum.", + "xrefs" : [ "MGI:csmith", "MP:0010793" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35822" + }, { + "val" : "FMA:14914" + }, { + "val" : "MA:0001626" + }, { + "val" : "NCIT:C32662" + }, { + "val" : "SCTID:1353004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "lbl" : "pyloric sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP].", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011093" + }, { + "val" : "EMAPA:19251" + }, { + "val" : "FMA:14916" + }, { + "val" : "MA:0002952" + }, { + "val" : "NCIT:C33433" + }, { + "val" : "SCTID:268073008" + }, { + "val" : "VHOG:0001466" + }, { + "val" : "XAO:0000457" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001204", + "lbl" : "mucosa of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a small intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001259" + }, { + "val" : "CALOHA:TS-0941" + }, { + "val" : "EMAPA:35780" + }, { + "val" : "FMA:14933" + }, { + "val" : "MA:0002686" + }, { + "val" : "NCIT:C33568" + }, { + "val" : "SCTID:362144000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001205", + "lbl" : "submucosa of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Submucosal tissue in the small intestines.", + "xrefs" : [ "Wikipedia:Small_intestinal_submucosa" ] + }, + "xrefs" : [ { + "val" : "BTO:0002112" + }, { + "val" : "FMA:14934" + }, { + "val" : "MA:0001562" + }, { + "val" : "NCIT:C33572" + }, { + "val" : "SCTID:691000" + }, { + "val" : "Wikipedia:Small_intestinal_submucosa" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001206", + "lbl" : "serosa of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a small intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14938" + }, { + "val" : "MA:0001558" + }, { + "val" : "SCTID:8266009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001207", + "lbl" : "mucosa of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2106" + }, { + "val" : "EMAPA:35467" + }, { + "val" : "FMA:14969" + }, { + "val" : "MA:0002688" + }, { + "val" : "NCIT:C32926" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001208", + "lbl" : "submucosa of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002111" + }, { + "val" : "FMA:14970" + }, { + "val" : "MA:0002690" + }, { + "val" : "NCIT:C32930" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001209", + "lbl" : "serosa of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14975" + }, { + "val" : "MA:0001546" + }, { + "val" : "NCIT:C32929" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "lbl" : "duodenal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP].", + "xrefs" : [ "Wikipedia:Brunner's_glands" ] + }, + "xrefs" : [ { + "val" : "BTO:0002376" + }, { + "val" : "EMAPA:36522" + }, { + "val" : "FMA:15060" + }, { + "val" : "GAID:314" + }, { + "val" : "MA:0001551" + }, { + "val" : "MESH:D002011" + }, { + "val" : "NCIT:C13010" + }, { + "val" : "SCTID:41298001" + }, { + "val" : "Wikipedia:Brunner's_glands" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001213", + "lbl" : "intestinal villus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold.", + "xrefs" : [ "MGI:csmith", "MGI:rbabiuk", "MP:0008108" ] + }, + "xrefs" : [ { + "val" : "BTO:0003121" + }, { + "val" : "EMAPA:35784" + }, { + "val" : "FMA:15072" + }, { + "val" : "MA:0001563" + }, { + "val" : "NCIT:C33874" + }, { + "val" : "SCTID:23230007" + }, { + "val" : "TAO:0005125" + }, { + "val" : "Wikipedia:Intestinal_villus" + }, { + "val" : "ZFA:0005125" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001215", + "lbl" : "inferior mesenteric vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Inferior_mesenteric_vein" ] + }, + "xrefs" : [ { + "val" : "BTO:0002782" + }, { + "val" : "EHDAA2:0000819" + }, { + "val" : "EHDAA:8712" + }, { + "val" : "EMAPA:18642" + }, { + "val" : "FMA:15391" + }, { + "val" : "MA:0002178" + }, { + "val" : "NCIT:C32782" + }, { + "val" : "SCTID:281055007" + }, { + "val" : "VHOG:0001118" + }, { + "val" : "Wikipedia:Inferior_mesenteric_vein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001238", + "lbl" : "lamina propria of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lamina propria that is part_of the small intestine.", + "xrefs" : [ "GOC:Obol" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35779" + }, { + "val" : "FMA:15651" + }, { + "val" : "MA:0001554" + }, { + "val" : "NCIT:C49297" + }, { + "val" : "SCTID:63588008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001242", + "lbl" : "intestinal mucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mucosal layer that lines the intestine.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "BTO:0000642" + }, { + "val" : "EMAPA:35440" + }, { + "val" : "FMA:15695" + }, { + "val" : "GAID:296" + }, { + "val" : "MA:0001537" + }, { + "val" : "MESH:D007413" + }, { + "val" : "NCIT:C49241" + }, { + "val" : "SCTID:362080002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001243", + "lbl" : "serosa of intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a wall of intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15701" + }, { + "val" : "MA:0001538" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "lbl" : "anus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts.", + "xrefs" : [ "Wikipedia:Anus", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "BTO:0001680" + }, { + "val" : "CALOHA:TS-2005" + }, { + "val" : "EV:0100082" + }, { + "val" : "FMA:15711" + }, { + "val" : "GAID:312" + }, { + "val" : "MA:0000331" + }, { + "val" : "NCIT:C43362" + }, { + "val" : "SCTID:181262009" + }, { + "val" : "TADS:0000066" + }, { + "val" : "TGMA:0001279" + }, { + "val" : "WBbt:0005364" + }, { + "val" : "Wikipedia:Anus" + }, { + "val" : "galen:Anus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "lbl" : "interlobular bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad.", + "xrefs" : [ "MP:0009500" ] + }, + "xrefs" : [ { + "val" : "FMA:15767" + }, { + "val" : "MA:0002668" + }, { + "val" : "NCIT:C32827" + }, { + "val" : "SCTID:83488001" + }, { + "val" : "Wikipedia:Interlobular_bile_ducts" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001262", + "lbl" : "wall of intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of a intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000647" + }, { + "val" : "EMAPA:35444" + }, { + "val" : "FMA:15949" + }, { + "val" : "MA:0001525" + }, { + "val" : "MA:0002693" + }, { + "val" : "NCIT:C49478" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "lbl" : "pancreatic acinus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct.", + "xrefs" : [ "MP:0009145" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35651" + }, { + "val" : "FMA:16011" + }, { + "val" : "MA:0002417" + }, { + "val" : "NCIT:C49268" + }, { + "val" : "SCTID:247604006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "lbl" : "pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO].", + "xrefs" : [ "GO:0031016" ] + }, + "xrefs" : [ { + "val" : "AAO:0010112" + }, { + "val" : "BTO:0000988" + }, { + "val" : "CALOHA:TS-0736" + }, { + "val" : "EFO:0000855" + }, { + "val" : "EHDAA2:0001367" + }, { + "val" : "EHDAA:6893" + }, { + "val" : "EMAPA:17503" + }, { + "val" : "EV:0100092" + }, { + "val" : "FMA:7198" + }, { + "val" : "GAID:334" + }, { + "val" : "MA:0000120" + }, { + "val" : "MAT:0000075" + }, { + "val" : "MESH:D010179" + }, { + "val" : "MIAA:0000075" + }, { + "val" : "NCIT:C12393" + }, { + "val" : "SCTID:181277001" + }, { + "val" : "TAO:0000140" + }, { + "val" : "VHOG:0000050" + }, { + "val" : "Wikipedia:Pancreas" + }, { + "val" : "XAO:0000136" + }, { + "val" : "ZFA:0000140" + }, { + "val" : "galen:Pancreas" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001265", + "lbl" : "trabecula of spleen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A trabecula that is part of a spleen.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35808" + }, { + "val" : "FMA:16027" + }, { + "val" : "MA:0000758" + }, { + "val" : "NCIT:C33607" + }, { + "val" : "SCTID:61987002" + }, { + "val" : "Wikipedia:Trabeculae_of_spleen" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001268", + "lbl" : "peritoneal fluid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Transudate contained in the peritoneal cavity.", + "xrefs" : [ "FMA:16515" ] + }, + "xrefs" : [ { + "val" : "BTO:0001031" + }, { + "val" : "EMAPA:35683" + }, { + "val" : "FMA:16515" + }, { + "val" : "MA:0002531" + }, { + "val" : "Wikipedia:Peritoneal_fluid" + }, { + "val" : "ncithesaurus:Peritoneal_Fluid" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001276", + "lbl" : "epithelium of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial layer of the stomach .", + "xrefs" : [ "MP:0000471" ] + }, + "xrefs" : [ { + "val" : "BTO:0000500" + }, { + "val" : "CALOHA:TS-2068" + }, { + "val" : "EHDAA2:0001918" + }, { + "val" : "EMAPA:17023" + }, { + "val" : "FMA:17091" + }, { + "val" : "MA:0001610" + }, { + "val" : "SCTID:64977002" + }, { + "val" : "VHOG:0001433" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "lbl" : "intestinal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial layer that lines the intestine.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "BTO:0000781" + }, { + "val" : "EMAPA:32873" + }, { + "val" : "FMA:17229" + }, { + "val" : "MA:0001536" + }, { + "val" : "NCIT:C49240" + }, { + "val" : "SCTID:266135004" + }, { + "val" : "TAO:0005124" + }, { + "val" : "Wikipedia:Intestinal_epithelium" + }, { + "val" : "ZFA:0005124" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001278", + "lbl" : "epithelium of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2105" + }, { + "val" : "EMAPA:35466" + }, { + "val" : "FMA:17301" + }, { + "val" : "MA:0001545" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "lbl" : "portal triad", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:csmith", "MP:0008993", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:17523" + }, { + "val" : "MA:0002499" + }, { + "val" : "NCIT:C33342" + }, { + "val" : "SCTID:362192000" + }, { + "val" : "Wikipedia:Portal_triad" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "lbl" : "liver parenchyma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The functional units of the liver including the lobules.", + "xrefs" : [ "MP:0008986" ] + }, + "xrefs" : [ { + "val" : "AAO:0010405" + }, { + "val" : "EHDAA2:0001004" + }, { + "val" : "EHDAA:2201" + }, { + "val" : "EMAPA:17203" + }, { + "val" : "FMA:17540" + }, { + "val" : "MA:0000366" + }, { + "val" : "NCIT:C32735" + }, { + "val" : "SCTID:363535004" + }, { + "val" : "UMLS:C0736268" + }, { + "val" : "VHOG:0000539" + }, { + "val" : "XAO:0000454" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "lbl" : "hepatic sinusoid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers.", + "xrefs" : [ "Wikipedia:Hepatic_sinusoid", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000999" + }, { + "val" : "EMAPA:17365" + }, { + "val" : "FMA:17543" + }, { + "val" : "MA:0000367" + }, { + "val" : "NCIT:C32733" + }, { + "val" : "SCTID:67435004" + }, { + "val" : "TAO:0005091" + }, { + "val" : "VHOG:0000708" + }, { + "val" : "Wikipedia:Hepatic_sinusoid" + }, { + "val" : "ZFA:0005091" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "lbl" : "intralobular bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule.", + "xrefs" : [ "MGI:csmith", "MP:0009499" ] + }, + "xrefs" : [ { + "val" : "FMA:17545" + }, { + "val" : "MA:0002669" + }, { + "val" : "NCIT:C32255" + }, { + "val" : "SCTID:227002" + }, { + "val" : "SCTID:269922006" + }, { + "val" : "Wikipedia:Canals_of_Hering" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001353", + "lbl" : "anal region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The anus and surrounding regions. Encompasses both internal and external regions, where present.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EFO:0000847" + }, { + "val" : "EHDAA2:0000122" + }, { + "val" : "EHDAA:2931" + }, { + "val" : "EMAPA:16831" + }, { + "val" : "MA:0000329" + }, { + "val" : "MAT:0000042" + }, { + "val" : "MIAA:0000042" + }, { + "val" : "NCIT:C32069" + }, { + "val" : "SCTID:362680001" + }, { + "val" : "VHOG:0000395" + }, { + "val" : "WBbt:0006919" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001366", + "lbl" : "parietal peritoneum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outer layer of peritoneum that is attached to the abdominal and pelvic walls.", + "xrefs" : [ "Wikipedia:Peritoneum#Types", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010816" + }, { + "val" : "EMAPA:16591" + }, { + "val" : "FMA:21451" + }, { + "val" : "SCTID:362700006" + }, { + "val" : "TAO:0005131" + }, { + "val" : "VHOG:0001527" + }, { + "val" : "Wikipedia:Parietal_peritoneum" + }, { + "val" : "ZFA:0005131" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001416", + "lbl" : "skin of abdomen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of an abdomen [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0000214" + }, { + "val" : "FMA:22988" + }, { + "val" : "FMA:23000" + }, { + "val" : "MA:0000523" + }, { + "val" : "NCIT:C52758" + }, { + "val" : "SCTID:361707007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001417", + "lbl" : "skin of neck", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:23021" + }, { + "val" : "FMA:23022" + }, { + "val" : "MA:0000590" + }, { + "val" : "NCIT:C52756" + }, { + "val" : "SCTID:361705004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001418", + "lbl" : "skin of thorax", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:23028" + }, { + "val" : "FMA:23029" + }, { + "val" : "MA:0000564" + }, { + "val" : "SCTID:281723000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001421", + "lbl" : "pectoral girdle region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions.", + "xrefs" : [ "FMA:23217", "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:23217" + }, { + "val" : "SCTID:229759004" + }, { + "val" : "VSAO:0000305" + }, { + "val" : "galen:ShoulderGirdle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001434", + "lbl" : "skeletal system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000027", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AAO:0000566" + }, { + "val" : "BTO:0001486" + }, { + "val" : "CALOHA:TS-1320" + }, { + "val" : "EFO:0000806" + }, { + "val" : "EHDAA2:0003168" + }, { + "val" : "EMAPA:35773" + }, { + "val" : "FMA:23881" + }, { + "val" : "MA:0000018" + }, { + "val" : "NCIT:C12788" + }, { + "val" : "TAO:0000434" + }, { + "val" : "VHOG:0001254" + }, { + "val" : "VSAO:0000027" + }, { + "val" : "XAO:0003060" + }, { + "val" : "ZFA:0000434" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001444", + "lbl" : "subdivision of head", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:24218" + }, { + "val" : "SCTID:123852005" + }, { + "val" : "XAO:0000040" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001456", + "lbl" : "face", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0003369" + }, { + "val" : "CALOHA:TS-2216" + }, { + "val" : "EMAPA:32763" + }, { + "val" : "FMA:24728" + }, { + "val" : "GAID:64" + }, { + "val" : "HAO:0000316" + }, { + "val" : "MA:0002473" + }, { + "val" : "MESH:D005145" + }, { + "val" : "NCIT:C13071" + }, { + "val" : "SCTID:302549007" + }, { + "val" : "Wikipedia:Face" + }, { + "val" : "galen:Face" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001458", + "lbl" : "skin of lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a lip [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:24764" + }, { + "val" : "MA:0001579" + }, { + "val" : "NCIT:C12291" + }, { + "val" : "SCTID:244092005" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001474", + "lbl" : "bone element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal element that is composed of bone tissue.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000057", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/277" ] + }, + "xrefs" : [ { + "val" : "AAO:0000047" + }, { + "val" : "AEO:0000082" + }, { + "val" : "BTO:0000140" + }, { + "val" : "CALOHA:TS-0088" + }, { + "val" : "EFO:0000298" + }, { + "val" : "EHDAA2:0003082" + }, { + "val" : "EMAPA:32782" + }, { + "val" : "ENVO:00002039" + }, { + "val" : "EV:0100140" + }, { + "val" : "FMA:30317" + }, { + "val" : "FMA:5018" + }, { + "val" : "GAID:92" + }, { + "val" : "MA:0001459" + }, { + "val" : "MAT:0000299" + }, { + "val" : "MIAA:0000299" + }, { + "val" : "NCIT:C12366" + }, { + "val" : "SCTID:90780006" + }, { + "val" : "TAO:0001514" + }, { + "val" : "VHOG:0001190" + }, { + "val" : "VSAO:0000057" + }, { + "val" : "Wikipedia:Bone" + }, { + "val" : "XAO:0000169" + }, { + "val" : "ZFA:0001514" + }, { + "val" : "galen:Bone" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001484", + "lbl" : "articular capsule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Articular_capsule" ] + }, + "xrefs" : [ { + "val" : "FMA:34836" + }, { + "val" : "GAID:263" + }, { + "val" : "MA:0001519" + }, { + "val" : "MESH:D017746" + }, { + "val" : "NCIT:C32259" + }, { + "val" : "NCIT:C84388" + }, { + "val" : "SCTID:182238002" + }, { + "val" : "Wikipedia:Articular_capsule" + }, { + "val" : "galen:JointCapsule" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001496", + "lbl" : "ascending aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia].", + "xrefs" : [ "GO:0035905", "Wikipedia:Ascending_aorta" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000147" + }, { + "val" : "EHDAA:9828" + }, { + "val" : "EMAPA:17014" + }, { + "val" : "FMA:3736" + }, { + "val" : "MA:0002570" + }, { + "val" : "NCIT:C32150" + }, { + "val" : "SCTID:181299009" + }, { + "val" : "Wikipedia:Ascending_aorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001508", + "lbl" : "arch of aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0004113" ] + }, + "xrefs" : [ { + "val" : "BTO:0000157" + }, { + "val" : "EFO:0002526" + }, { + "val" : "EHDAA2:0000132" + }, { + "val" : "EMAPA:17613" + }, { + "val" : "FMA:3768" + }, { + "val" : "GAID:471" + }, { + "val" : "MA:0000475" + }, { + "val" : "SCTID:181300001" + }, { + "val" : "VHOG:0001196" + }, { + "val" : "Wikipedia:Arch_of_aorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001514", + "lbl" : "descending aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted].", + "xrefs" : [ "GO:0035906", "Wikipedia:Descending_aorta" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18606" + }, { + "val" : "FMA:3784" + }, { + "val" : "MA:0002571" + }, { + "val" : "NCIT:C32455" + }, { + "val" : "SCTID:261399002" + }, { + "val" : "Wikipedia:Descending_aorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001515", + "lbl" : "thoracic aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.", + "xrefs" : [ "MP:0010468", "http://www.medterms.com" ] + }, + "xrefs" : [ { + "val" : "BTO:0000157" + }, { + "val" : "EFO:0002525" + }, { + "val" : "EMAPA:18603" + }, { + "val" : "FMA:3786" + }, { + "val" : "GAID:471" + }, { + "val" : "MA:0002569" + }, { + "val" : "MESH:D001013" + }, { + "val" : "NCIT:C33766" + }, { + "val" : "SCTID:302510009" + }, { + "val" : "Wikipedia:Thoracic_aorta" + }, { + "val" : "galen:ThoracicAorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001516", + "lbl" : "abdominal aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted].", + "xrefs" : [ "BTO:0002976", "Wikipedia:Abdominal_aorta" ] + }, + "xrefs" : [ { + "val" : "BTO:0002976" + }, { + "val" : "EFO:0002524" + }, { + "val" : "EMAPA:17856" + }, { + "val" : "FMA:3789" + }, { + "val" : "GAID:470" + }, { + "val" : "MA:0000474" + }, { + "val" : "MESH:D001012" + }, { + "val" : "NCIT:C32038" + }, { + "val" : "SCTID:244231007" + }, { + "val" : "Wikipedia:Abdominal_aorta" + }, { + "val" : "galen:AbdominalAorta" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001529", + "lbl" : "brachiocephalic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery.", + "xrefs" : [ "MGI:csmith", "MP:0010663" ] + }, + "xrefs" : [ { + "val" : "EFO:0002550" + }, { + "val" : "EHDAA2:0000835" + }, { + "val" : "EMAPA:17615" + }, { + "val" : "FMA:3932" + }, { + "val" : "GAID:476" + }, { + "val" : "MA:0001922" + }, { + "val" : "MESH:D016122" + }, { + "val" : "NCIT:C32814" + }, { + "val" : "SCTID:244244002" + }, { + "val" : "Wikipedia:Brachiocephalic_artery" + }, { + "val" : "galen:BrachioCephalicArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001530", + "lbl" : "common carotid artery plus branches", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm].", + "xrefs" : [ "Wikipedia:Common_carotid_artery" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0116" + }, { + "val" : "EHDAA2:0000217" + }, { + "val" : "EHDAA:7331" + }, { + "val" : "EMAPA:17855" + }, { + "val" : "FMA:3939" + }, { + "val" : "GAID:479" + }, { + "val" : "MA:0001926" + }, { + "val" : "MESH:D017536" + }, { + "val" : "NCIT:C32352" + }, { + "val" : "SCTID:362041005" + }, { + "val" : "VHOG:0000272" + }, { + "val" : "Wikipedia:Common_carotid_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001533", + "lbl" : "subclavian artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta.", + "xrefs" : [ "ISBN:0073040584", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010232" + }, { + "val" : "EHDAA2:0001933" + }, { + "val" : "EHDAA:4357" + }, { + "val" : "EMAPA:17617" + }, { + "val" : "FMA:3951" + }, { + "val" : "GAID:511" + }, { + "val" : "MA:0002045" + }, { + "val" : "MESH:D013348" + }, { + "val" : "NCIT:C33643" + }, { + "val" : "SCTID:265790007" + }, { + "val" : "TAO:0005086" + }, { + "val" : "Wikipedia:Subclavian_artery" + }, { + "val" : "XAO:0000365" + }, { + "val" : "ZFA:0005086" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001534", + "lbl" : "right subclavian artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The subclavian artery that supplies the right pectoral appendage.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004514" + }, { + "val" : "FMA:3953" + }, { + "val" : "MA:0002047" + }, { + "val" : "NCIT:C33490" + }, { + "val" : "SCTID:244246000" + }, { + "val" : "Wikipedia:Subclavian_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001555", + "lbl" : "digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tube extending from the mouth to the anus.", + "xrefs" : [ "Wikipedia:Talk:Human_gastrointestinal_tract", "https://github.com/geneontology/go-ontology/issues/7549" ] + }, + "xrefs" : [ { + "val" : "AAO:0010023" + }, { + "val" : "BILA:0000083" + }, { + "val" : "BTO:0000511" + }, { + "val" : "BTO:0000545" + }, { + "val" : "EHDAA2:0000726" + }, { + "val" : "EHDAA:518" + }, { + "val" : "EMAPA:16247" + }, { + "val" : "FMA:45615" + }, { + "val" : "MA:0000917" + }, { + "val" : "NCIT:C34082" + }, { + "val" : "TAO:0000112" + }, { + "val" : "TGMA:0001819" + }, { + "val" : "VHOG:0000309" + }, { + "val" : "WBbt:0005743" + }, { + "val" : "ZFA:0000112" + }, { + "val" : "galen:AlimentaryTract" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001558", + "lbl" : "lower respiratory tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified].", + "xrefs" : [ "Wikipedia:Lower_respiratory_tract", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001036" + }, { + "val" : "EMAPA:16738" + }, { + "val" : "FMA:45662" + }, { + "val" : "MA:0000435" + }, { + "val" : "SCTID:281488008" + }, { + "val" : "VHOG:0000382" + }, { + "val" : "Wikipedia:Lower_respiratory_tract" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001584", + "lbl" : "left subclavian artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The subclavian artery that supplies the left pectoral appendage.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:4694" + }, { + "val" : "MA:0002046" + }, { + "val" : "NCIT:C32972" + }, { + "val" : "SCTID:244245001" + }, { + "val" : "Wikipedia:Subclavian_artery" + } ] + } + }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0001585", "lbl" : "anterior vena cava", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart.", + "xrefs" : [ "Wikipedia:Superior_vena_cava", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0002683" + }, { + "val" : "EHDAA2:0001962" + }, { + "val" : "EHDAA:8726" + }, { + "val" : "EMAPA:18417" + }, { + "val" : "FMA:4720" + }, { + "val" : "GAID:549" + }, { + "val" : "MA:0000481" + }, { + "val" : "MESH:D014683" + }, { + "val" : "NCIT:C12816" + }, { + "val" : "SCTID:181368006" + }, { + "val" : "VHOG:0001195" + }, { + "val" : "Wikipedia:Superior_vena_cava" + }, { + "val" : "galen:SuperiorVenaCava" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001586", + "lbl" : "internal jugular vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Internal_jugular_vein" ] + }, + "xrefs" : [ { + "val" : "AAO:0010236" + }, { + "val" : "EHDAA2:0000877" + }, { + "val" : "EHDAA:5407" + }, { + "val" : "EMAPA:17620" + }, { + "val" : "FMA:4724" + }, { + "val" : "MA:0002157" + }, { + "val" : "NCIT:C32849" + }, { + "val" : "RETIRED_EHDAA2:0000878" + }, { + "val" : "SCTID:181372005" + }, { + "val" : "Wikipedia:Internal_jugular_vein" + }, { + "val" : "XAO:0000382" + }, { + "val" : "galen:InternalJugularVein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001592", + "lbl" : "bronchial vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Bronchial_veins" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36284" + }, { + "val" : "FMA:4749" + }, { + "val" : "MA:0002088" + }, { + "val" : "NCIT:C53031" + }, { + "val" : "SCTID:198293000" + }, { + "val" : "Wikipedia:Bronchial_veins" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001605", + "lbl" : "ciliary muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Ciliary_muscle" ] + }, + "xrefs" : [ { + "val" : "BTO:0000654" + }, { + "val" : "EMAPA:35240" + }, { + "val" : "FMA:49151" + }, { + "val" : "MA:0001269" + }, { + "val" : "NCIT:C32315" + }, { + "val" : "SCTID:280862009" + }, { + "val" : "Wikipedia:Ciliary_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001606", + "lbl" : "muscle of iris", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:49154" + }, { + "val" : "MA:0001287" + }, { + "val" : "SCTID:280888007" + }, { + "val" : "Wikipedia:Iris_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "lbl" : "sphincter pupillae", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphincter muscle that is part of the iris.", + "xrefs" : [ "Wikipedia:Iris_sphincter_muscle" ] + }, + "xrefs" : [ { + "val" : "BTO:0000656" + }, { + "val" : "EMAPA:35788" + }, { + "val" : "FMA:49157" + }, { + "val" : "MA:0001289" + }, { + "val" : "NCIT:C33586" + }, { + "val" : "SCTID:280889004" + }, { + "val" : "Wikipedia:Iris_sphincter_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "lbl" : "dilatator pupillae", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Iris_dilator_muscle" ] + }, + "xrefs" : [ { + "val" : "BTO:0001371" + }, { + "val" : "EMAPA:35286" + }, { + "val" : "FMA:49158" + }, { + "val" : "MA:0001288" + }, { + "val" : "NCIT:C32463" + }, { + "val" : "SCTID:280890008" + }, { + "val" : "Wikipedia:Iris_dilator_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001612", + "lbl" : "facial artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A branch of the external carotid artery that supplies structures of the face. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Facial_artery" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19213" + }, { + "val" : "FMA:49549" + }, { + "val" : "MA:0001950" + }, { + "val" : "NCIT:C32578" + }, { + "val" : "SCTID:181328007" + }, { + "val" : "Wikipedia:Facial_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001630", + "lbl" : "muscle organ", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO].", + "xrefs" : [ "GO:0007517" ] + }, + "xrefs" : [ { + "val" : "EV:0100146" + }, { + "val" : "FMA:5022" + }, { + "val" : "GAID:131" + }, { + "val" : "MA:0000015" + }, { + "val" : "SCTID:71616004" + }, { + "val" : "TAO:0005145" + }, { + "val" : "VHOG:0001245" + }, { + "val" : "XAO:0000172" + }, { + "val" : "ZFA:0005145" + }, { + "val" : "galen:Muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001637", + "lbl" : "artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition].", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AAO:0010211" + }, { + "val" : "AEO:0000208" + }, { + "val" : "BTO:0000573" + }, { + "val" : "CALOHA:TS-0054" + }, { + "val" : "EFO:0000814" + }, { + "val" : "EHDAA2:0003253" + }, { + "val" : "EMAPA:35147" + }, { + "val" : "EV:0100026" + }, { + "val" : "FMA:50720" + }, { + "val" : "GAID:468" + }, { + "val" : "MA:0000064" + }, { + "val" : "MAT:0000034" + }, { + "val" : "MESH:D001158" + }, { + "val" : "MIAA:0000034" + }, { + "val" : "NCIT:C12372" + }, { + "val" : "SCTID:362877004" + }, { + "val" : "TAO:0000005" + }, { + "val" : "VHOG:0001251" + }, { + "val" : "Wikipedia:Artery" + }, { + "val" : "XAO:0000114" + }, { + "val" : "ZFA:0000005" + }, { + "val" : "galen:Artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001638", + "lbl" : "vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the tubular branching vessels that carry blood from the capillaries toward the heart.", + "xrefs" : [ "Wikipedia:Vein" ] + }, + "xrefs" : [ { + "val" : "AAO:0010212" + }, { + "val" : "AEO:0000209" + }, { + "val" : "BTO:0000234" + }, { + "val" : "CALOHA:TS-1108" + }, { + "val" : "EFO:0000816" + }, { + "val" : "EHDAA2:0003254" + }, { + "val" : "EMAPA:35906" + }, { + "val" : "EV:0100031" + }, { + "val" : "FMA:50723" + }, { + "val" : "GAID:492" + }, { + "val" : "MA:0000067" + }, { + "val" : "MAT:0000037" + }, { + "val" : "MESH:D014680" + }, { + "val" : "MIAA:0000037" + }, { + "val" : "NCIT:C12814" + }, { + "val" : "SCTID:181367001" + }, { + "val" : "TAO:0000082" + }, { + "val" : "VHOG:0001743" + }, { + "val" : "Wikipedia:Vein" + }, { + "val" : "XAO:0000115" + }, { + "val" : "ZFA:0000082" + }, { + "val" : "galen:Vein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001639", + "lbl" : "hepatic portal vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portal vein that transports nutrients from the digestive tract to the liver[Kardong].", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Hepatic_portal_vein", "http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376" ] + }, + "xrefs" : [ { + "val" : "AAO:0010214" + }, { + "val" : "FMA:50735" + }, { + "val" : "MA:0002132" + }, { + "val" : "TAO:0005090" + }, { + "val" : "VHOG:0000642" + }, { + "val" : "Wikipedia:Hepatic_portal_vein" + }, { + "val" : "ZFA:0005090" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "lbl" : "celiac artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first major branch of the abdominal aorta.", + "xrefs" : [ "Wikipedia:Celiac_artery" ] + }, + "comments" : [ "dorsal aorta in Kardong" ], + "xrefs" : [ { + "val" : "EHDAA2:0004519" + }, { + "val" : "EMAPA:35202" + }, { + "val" : "FMA:50737" + }, { + "val" : "GAID:483" + }, { + "val" : "MA:0001931" + }, { + "val" : "MESH:D002445" + }, { + "val" : "NCIT:C52846" + }, { + "val" : "SCTID:181340007" + }, { + "val" : "Wikipedia:Celiac_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001645", + "lbl" : "trigeminal nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw).", + "xrefs" : [ "ISBN:0471209627", "Wikipedia:Trigeminal_nerve" ] + }, + "xrefs" : [ { + "val" : "AAO:0010470" + }, { + "val" : "BAMS:5n" + }, { + "val" : "BAMS:Vn" + }, { + "val" : "BAMS:nV" + }, { + "val" : "BIRNLEX:869" + }, { + "val" : "BM:VN" + }, { + "val" : "BTO:0001072" + }, { + "val" : "EFO:0001402" + }, { + "val" : "EHDAA2:0002084" + }, { + "val" : "EHDAA:3738" + }, { + "val" : "EMAPA:17576" + }, { + "val" : "FMA:50866" + }, { + "val" : "GAID:726" + }, { + "val" : "MA:0001100" + }, { + "val" : "MBA:901" + }, { + "val" : "MESH:D014276" + }, { + "val" : "MFMO:0000093" + }, { + "val" : "NCIT:C12806" + }, { + "val" : "SCTID:362459002" + }, { + "val" : "TAO:0000697" + }, { + "val" : "VHOG:0000704" + }, { + "val" : "Wikipedia:Trigeminal_nerve" + }, { + "val" : "XAO:0003092" + }, { + "val" : "ZFA:0000697" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001651", + "lbl" : "right pulmonary artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pulmonary artery that supplies the right lung.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:50872" + }, { + "val" : "MA:0002500" + }, { + "val" : "NCIT:C33489" + }, { + "val" : "SCTID:244235003" + }, { + "val" : "Wikipedia:Right_pulmonary_artery" + }, { + "val" : "galen:RightPulmonaryArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001652", + "lbl" : "left pulmonary artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pulmonary artery that supplies the left lung.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:50873" + }, { + "val" : "MA:0002032" + }, { + "val" : "NCIT:C32971" + }, { + "val" : "SCTID:244234004" + }, { + "val" : "Wikipedia:Left_pulmonary_artery" + }, { + "val" : "galen:LeftPulmonaryArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001653", + "lbl" : "facial vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Facial_vein" ] + }, + "xrefs" : [ { + "val" : "AAO:0010513" + }, { + "val" : "EMAPA:19220" + }, { + "val" : "FMA:50874" + }, { + "val" : "MA:0002115" + }, { + "val" : "NCIT:C32579" + }, { + "val" : "SCTID:181374006" + }, { + "val" : "Wikipedia:Facial_vein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001675", + "lbl" : "trigeminal ganglion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cranial ganglion that is associated with and extends fibers into the trigeminal nerve.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.ncbi.nlm.nih.gov/books/NBK53171", "https://github.com/obophenotype/uberon/issues/693" ] + }, + "xrefs" : [ { + "val" : "AAO:0011107" + }, { + "val" : "BAMS:5Gn" + }, { + "val" : "BAMS:GV" + }, { + "val" : "BTO:0001231" + }, { + "val" : "EFO:0000903" + }, { + "val" : "EHDAA2:0002085" + }, { + "val" : "EHDAA:2113" + }, { + "val" : "EMAPA:16797" + }, { + "val" : "FMA:52618" + }, { + "val" : "GAID:725" + }, { + "val" : "MA:0001080" + }, { + "val" : "MAT:0000511" + }, { + "val" : "MESH:D012668" + }, { + "val" : "NCIT:C62642" + }, { + "val" : "SCTID:244449009" + }, { + "val" : "TAO:0000295" + }, { + "val" : "VHOG:0000694" + }, { + "val" : "Wikipedia:Trigeminal_ganglion" + }, { + "val" : "XAO:0000427" + }, { + "val" : "XAO:0000428" + }, { + "val" : "ZFA:0000295" + }, { + "val" : "neuronames:1402" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001676", + "lbl" : "occipital bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bone at the lower, posterior part of the skull.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0005269" ] + }, + "xrefs" : [ { + "val" : "EMAPA:25112" + }, { + "val" : "FMA:52735" + }, { + "val" : "GAID:227" + }, { + "val" : "MA:0001468" + }, { + "val" : "MESH:D009777" + }, { + "val" : "NCIT:C12757" + }, { + "val" : "SCTID:181796003" + }, { + "val" : "Wikipedia:Occipital_bone" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "lbl" : "sphenoid bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended.", + "xrefs" : [ "Wikipedia:Sphenoid_bone" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2343" + }, { + "val" : "EMAPA:18340" + }, { + "val" : "FMA:52736" + }, { + "val" : "GAID:230" + }, { + "val" : "MA:0001472" + }, { + "val" : "MESH:D013100" + }, { + "val" : "NCIT:C12790" + }, { + "val" : "SCTID:272676008" + }, { + "val" : "Wikipedia:Sphenoid_bone" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "lbl" : "ethmoid bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP].", + "xrefs" : [ "Wikipedia:Ethmoid_bone" ] + }, + "xrefs" : [ { + "val" : "BTO:0004140" + }, { + "val" : "EMAPA:19018" + }, { + "val" : "FMA:52740" + }, { + "val" : "GAID:212" + }, { + "val" : "MA:0001483" + }, { + "val" : "MESH:D005004" + }, { + "val" : "NCIT:C12711" + }, { + "val" : "SCTID:272674006" + }, { + "val" : "VHOG:0001317" + }, { + "val" : "Wikipedia:Ethmoid_bone" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "lbl" : "orbit of skull", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball.", + "xrefs" : [ "TAO:0001410", "Wikipedia:Orbit_(anatomy)", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004687" + }, { + "val" : "FMA:53074" + }, { + "val" : "GAID:223" + }, { + "val" : "MA:0002482" + }, { + "val" : "MESH:D009915" + }, { + "val" : "NCIT:C12347" + }, { + "val" : "TAO:0001410" + }, { + "val" : "Wikipedia:Orbit_(anatomy)" + }, { + "val" : "XAO:0003171" + }, { + "val" : "ZFA:0001410" + }, { + "val" : "galen:Orbit" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001703", + "lbl" : "neurocranium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof.", + "xrefs" : [ "PMID:11523816", "TAO:MAH", "Wikipedia:Neuroranium", "ZFA:0001580" ] + }, + "xrefs" : [ { + "val" : "FMA:53672" + }, { + "val" : "MA:0000317" + }, { + "val" : "SCTID:361731002" + }, { + "val" : "TAO:0001580" + }, { + "val" : "Wikipedia:Neuroranium" + }, { + "val" : "XAO:0003170" + }, { + "val" : "ZFA:0001580" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001708", + "lbl" : "jaw skeleton", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skeleton which includes upper and lower jaw skeletons.", + "xrefs" : [ "Wikipedia:Jaw", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000988" + }, { + "val" : "BTO:0001749" + }, { + "val" : "EMAPA:35455" + }, { + "val" : "FMA:54396" + }, { + "val" : "GAID:214" + }, { + "val" : "MA:0001905" + }, { + "val" : "MESH:D007568" + }, { + "val" : "NCIT:C48821" + }, { + "val" : "SCTID:181811001" + }, { + "val" : "TAO:0001227" + }, { + "val" : "Wikipedia:Jaw" + }, { + "val" : "ZFA:0001227" + }, { + "val" : "galen:Jaw" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "lbl" : "upper jaw region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm].", + "xrefs" : [ "Wikipedia:Upper_jaw", "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "See notes for jaw w.r.t skeletal element vs subdivision of head." ], + "xrefs" : [ { + "val" : "AAO:0000620" + }, { + "val" : "EHDAA2:0002118" + }, { + "val" : "EHDAA2:0004607" + }, { + "val" : "EHDAA:8025" + }, { + "val" : "EMAPA:17924" + }, { + "val" : "FMA:59399" + }, { + "val" : "SCTID:362636001" + }, { + "val" : "VHOG:0000454" + }, { + "val" : "Wikipedia:Upper_jaw" + }, { + "val" : "ncithesaurus:Upper_Jaw" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001710", + "lbl" : "lower jaw region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm].", + "xrefs" : [ "Wikipedia:Lower_jaw" ] + }, + "comments" : [ "See notes for jaw w.r.t skeletal element vs subdivision of head" ], + "xrefs" : [ { + "val" : "AAO:0000272" + }, { + "val" : "EFO:0003660" + }, { + "val" : "EHDAA2:0001018" + }, { + "val" : "EHDAA:7995" + }, { + "val" : "EMAPA:17906" + }, { + "val" : "FMA:59398" + }, { + "val" : "MESH:D008334" + }, { + "val" : "SCTID:362637005" + }, { + "val" : "VHOG:0000453" + }, { + "val" : "Wikipedia:Lower_jaw" + }, { + "val" : "ncithesaurus:Lower_Jaw" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001714", + "lbl" : "cranial ganglion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The groups of nerve cell bodies associated with the twelve cranial nerves.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:csmith", "MP:0001081", "PMID:9362461" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:2597" + }, { + "val" : "BTO:0000106" + }, { + "val" : "EFO:0000902" + }, { + "val" : "EMAPA:16659" + }, { + "val" : "FMA:54502" + }, { + "val" : "MA:0000213" + }, { + "val" : "MA:0000214" + }, { + "val" : "MAT:0000200" + }, { + "val" : "MIAA:0000200" + }, { + "val" : "SCTID:244448001" + }, { + "val" : "TAO:0000013" + }, { + "val" : "VHOG:0000076" + }, { + "val" : "Wikipedia:Cranial_nerve_ganglion" + }, { + "val" : "XAO:0000027" + }, { + "val" : "ZFA:0000013" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001731", + "lbl" : "cavity of pharynx", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is enclosed by a pharynx.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0010435" + }, { + "val" : "BSA:0000113" + }, { + "val" : "BTO:0002097" + }, { + "val" : "EMAPA:18381" + }, { + "val" : "FMA:54935" + }, { + "val" : "SCTID:180543003" + }, { + "val" : "XAO:0000105" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001766", + "lbl" : "anterior chamber of eyeball", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens.", + "xrefs" : [ "MESH:A09.371.060.067", "MP:0005205" ] + }, + "xrefs" : [ { + "val" : "BTO:0002084" + }, { + "val" : "EHDAA2:0000129" + }, { + "val" : "EHDAA:9033" + }, { + "val" : "EMAPA:18231" + }, { + "val" : "FMA:58078" + }, { + "val" : "GAID:889" + }, { + "val" : "MA:0000262" + }, { + "val" : "MESH:D000867" + }, { + "val" : "NCIT:C12667" + }, { + "val" : "SCTID:181160009" + }, { + "val" : "VHOG:0001431" + }, { + "val" : "Wikipedia:Anterior_chamber_of_eyeball" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001768", + "lbl" : "uvea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited].", + "xrefs" : [ "MP:0005197", "Wikipedia:Uvea" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2228" + }, { + "val" : "EMAPA:35901" + }, { + "val" : "FMA:58103" + }, { + "val" : "GAID:912" + }, { + "val" : "MA:0002480" + }, { + "val" : "MESH:D014602" + }, { + "val" : "NCIT:C12811" + }, { + "val" : "SCTID:280648000" + }, { + "val" : "Wikipedia:Uvea" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001769", + "lbl" : "iris", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0001322" ] + }, + "xrefs" : [ { + "val" : "AAO:0010347" + }, { + "val" : "BTO:0000653" + }, { + "val" : "CALOHA:TS-0491" + }, { + "val" : "EFO:0004245" + }, { + "val" : "EMAPA:19154" + }, { + "val" : "EV:0100345" + }, { + "val" : "FMA:58235" + }, { + "val" : "GAID:917" + }, { + "val" : "MA:0000273" + }, { + "val" : "MESH:D007498" + }, { + "val" : "NCIT:C12737" + }, { + "val" : "SCTID:181164000" + }, { + "val" : "TAO:0001238" + }, { + "val" : "VHOG:0000101" + }, { + "val" : "Wikipedia:Iris_(anatomy)" + }, { + "val" : "XAO:0000185" + }, { + "val" : "ZFA:0001238" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001772", + "lbl" : "corneal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The smooth stratified squamous epithelium that covers the outer surface of the cornea.", + "xrefs" : [ "MESH:A09.371.060.217.325", "MGI:smb", "MP:0006000" ] + }, + "xrefs" : [ { + "val" : "BTO:0000287" + }, { + "val" : "CALOHA:TS-0173" + }, { + "val" : "EFO:0001917" + }, { + "val" : "EHDAA2:0000319" + }, { + "val" : "EMAPA:17162" + }, { + "val" : "FMA:58263" + }, { + "val" : "GAID:895" + }, { + "val" : "MA:0001243" + }, { + "val" : "MESH:D019573" + }, { + "val" : "NCIT:C12928" + }, { + "val" : "SCTID:368825001" + }, { + "val" : "TAO:0002187" + }, { + "val" : "Wikipedia:Corneal_epithelium" + }, { + "val" : "ZFA:0001683" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001773", + "lbl" : "sclera", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP].", + "xrefs" : [ "Wikipedia:Sclera", "ZFIN:ZDB-PUB-050701-15" ] + }, + "comments" : [ "Disease notes: implicated in rheumatoid arthritis." ], + "xrefs" : [ { + "val" : "AAO:0010354" + }, { + "val" : "BTO:0001606" + }, { + "val" : "EMAPA:19027" + }, { + "val" : "EV:0100342" + }, { + "val" : "FMA:58269" + }, { + "val" : "GAID:911" + }, { + "val" : "MA:0000280" + }, { + "val" : "MESH:D012590" + }, { + "val" : "NCIT:C12784" + }, { + "val" : "SCTID:181163006" + }, { + "val" : "VHOG:0001274" + }, { + "val" : "Wikipedia:Sclera" + }, { + "val" : "XAO:0000183" + }, { + "val" : "ZFA:0005563" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001774", + "lbl" : "skeletal muscle of trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal muscle organ that is part of the trunk region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000611" + }, { + "val" : "EMAPA:35888" + }, { + "val" : "FMA:58274" + }, { + "val" : "MA:0000514" + }, { + "val" : "TAO:0000473" + }, { + "val" : "XAO:0003230" + }, { + "val" : "ZFA:0000473" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001775", + "lbl" : "ciliary body", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0005099", "Wikipedia:Ciliary_body" ] + }, + "xrefs" : [ { + "val" : "AAO:0010341" + }, { + "val" : "BTO:0000260" + }, { + "val" : "CALOHA:TS-0694" + }, { + "val" : "EMAPA:19065" + }, { + "val" : "EV:0100346" + }, { + "val" : "FMA:58295" + }, { + "val" : "GAID:916" + }, { + "val" : "MA:0000264" + }, { + "val" : "MESH:D002924" + }, { + "val" : "NCIT:C12345" + }, { + "val" : "SCTID:263340007" + }, { + "val" : "VHOG:0000102" + }, { + "val" : "Wikipedia:Ciliary_body" + }, { + "val" : "XAO:0000186" + }, { + "val" : "neuronames:1571" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001776", + "lbl" : "optic choroid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP].", + "xrefs" : [ "Wikipedia:Choroid" ] + }, + "xrefs" : [ { + "val" : "BTO:0001829" + }, { + "val" : "CALOHA:TS-2054" + }, { + "val" : "EMAPA:19077" + }, { + "val" : "EV:0100347" + }, { + "val" : "FMA:58298" + }, { + "val" : "GAID:913" + }, { + "val" : "MA:0000263" + }, { + "val" : "MESH:D002829" + }, { + "val" : "NCIT:C12344" + }, { + "val" : "SCTID:181172003" + }, { + "val" : "TAO:0005229" + }, { + "val" : "VHOG:0001568" + }, { + "val" : "Wikipedia:Choroid" + }, { + "val" : "ZFA:0005229" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001777", + "lbl" : "substantia propria of cornea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The lamellated connective tissue of the cornea between the Bowman and Descemet membranes.", + "xrefs" : [ "ISBN:0-683-40008-8", "MESH:A09.371.060.217.228", "MP:0005300" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1138" + }, { + "val" : "EFO:0002514" + }, { + "val" : "EMAPA:17602" + }, { + "val" : "FMA:58306" + }, { + "val" : "GAID:893" + }, { + "val" : "MA:0001245" + }, { + "val" : "MESH:D003319" + }, { + "val" : "NCIT:C12699" + }, { + "val" : "SCTID:362511000" + }, { + "val" : "TAO:0002189" + }, { + "val" : "Wikipedia:Corneal_stroma" + }, { + "val" : "ZFA:0001685" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001778", + "lbl" : "ciliary epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A double layer covering the ciliary body that produces aqueous humor.", + "xrefs" : [ "Wikipedia:Ciliary_body#Ciliary_epithelium" ] + }, + "xrefs" : [ { + "val" : "BTO:0001770" + }, { + "val" : "CALOHA:TS-0695" + }, { + "val" : "EMAPA:35239" + }, { + "val" : "FMA:58464" + }, { + "val" : "MA:0001238" + }, { + "val" : "NCIT:C32314" + }, { + "val" : "SCTID:280870004" + }, { + "val" : "Wikipedia:Ciliary_body#Ciliary_epithelium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001779", + "lbl" : "iris stroma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae.", + "xrefs" : [ "Wikipedia:Iris_stroma", "http://www.drugs.com/dict/stroma-of-iris.html" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35451" + }, { + "val" : "FMA:58526" + }, { + "val" : "MA:0002777" + }, { + "val" : "SCTID:280882008" + }, { + "val" : "Wikipedia:Iris_stroma" + }, { + "val" : "ZFA:0005569" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001780", + "lbl" : "spinal nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified].", + "xrefs" : [ "MESH:A08.800.800.720", "MP:0001077" ] + }, + "xrefs" : [ { + "val" : "AAO:0011101" + }, { + "val" : "BAMS:spin" + }, { + "val" : "BTO:0000870" + }, { + "val" : "EHDAA2:0001898" + }, { + "val" : "EMAPA:16989" + }, { + "val" : "FMA:5858" + }, { + "val" : "GAID:841" + }, { + "val" : "MA:0000233" + }, { + "val" : "MESH:D013127" + }, { + "val" : "NCIT:C12792" + }, { + "val" : "SCTID:361099009" + }, { + "val" : "VHOG:0000824" + }, { + "val" : "Wikipedia:Spinal_nerve" + }, { + "val" : "XAO:0003101" + }, { + "val" : "neuronames:1228" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001781", + "lbl" : "layer of retina", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the layers that make up the retina[MP].", + "xrefs" : [ "MP:0003727" ] + }, + "xrefs" : [ { + "val" : "AAO:0010353" + }, { + "val" : "EMAPA:35742" + }, { + "val" : "FMA:58617" + }, { + "val" : "MA:0001319" + }, { + "val" : "NCIT:C49328" + }, { + "val" : "SCTID:280657006" + }, { + "val" : "XAO:0000266" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001785", + "lbl" : "cranial nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord.", + "xrefs" : [ "Wikipedia:Cranial_nerve" ] + }, + "xrefs" : [ { + "val" : "AAO:0000108" + }, { + "val" : "BAMS:cran" + }, { + "val" : "BIRNLEX:1623" + }, { + "val" : "BTO:0001104" + }, { + "val" : "EHDAA2:0000323" + }, { + "val" : "EMAPA:17264" + }, { + "val" : "FMA:5865" + }, { + "val" : "GAID:802" + }, { + "val" : "MA:0000215" + }, { + "val" : "MBA:967" + }, { + "val" : "MESH:D003391" + }, { + "val" : "NCIT:C12700" + }, { + "val" : "SCTID:244447006" + }, { + "val" : "TAO:0000641" + }, { + "val" : "VHOG:0000279" + }, { + "val" : "Wikipedia:Cranial_nerve" + }, { + "val" : "XAO:0000429" + }, { + "val" : "XAO:0003089" + }, { + "val" : "ZFA:0000641" + }, { + "val" : "neuronames:1227" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001796", + "lbl" : "aqueous humor of eyeball", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thick watery refractive medium that fills the space between the lens and the cornea[WP].", + "xrefs" : [ "Wikipedia:Aqueous_humor" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000139" + }, { + "val" : "EHDAA:10196" + }, { + "val" : "EMAPA:18232" + }, { + "val" : "ENVO:02000024" + }, { + "val" : "FMA:58819" + }, { + "val" : "GAID:890" + }, { + "val" : "MA:0001236" + }, { + "val" : "MESH:D001082" + }, { + "val" : "NCIT:C13190" + }, { + "val" : "SCTID:280587006" + }, { + "val" : "VHOG:0000548" + }, { + "val" : "Wikipedia:Aqueous_humor" + }, { + "val" : "ZFA:0005564" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001800", + "lbl" : "sensory ganglion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells.", + "xrefs" : [ "MP:0000960" ] + }, + "xrefs" : [ { + "val" : "AEO:0001000" + }, { + "val" : "BTO:0005630" + }, { + "val" : "EMAPA:36596" + }, { + "val" : "FMA:5885" + }, { + "val" : "MA:0002566" + }, { + "val" : "MESH:D017950" + }, { + "val" : "NCIT:C13060" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001801", + "lbl" : "anterior segment of eyeball", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive).", + "xrefs" : [ "ISBN:0-683-40008-8", "MESH:A09.371.060", "MP:0005193" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36594" + }, { + "val" : "FMA:58865" + }, { + "val" : "MA:0002484" + }, { + "val" : "MESH:D000869" + }, { + "val" : "NCIT:C12668" + }, { + "val" : "SCTID:280658001" + }, { + "val" : "Wikipedia:Anterior_segment_of_eyeball" + }, { + "val" : "ZFA:0005566" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001802", + "lbl" : "posterior segment of eyeball", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive).", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0005195" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36595" + }, { + "val" : "FMA:58868" + }, { + "val" : "MA:0002485" + }, { + "val" : "NCIT:C12906" + }, { + "val" : "SCTID:280659009" + }, { + "val" : "Wikipedia:Posterior_segment_of_eyeball" + }, { + "val" : "ZFA:0005567" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001803", + "lbl" : "epithelium of lens", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of epithelial cells that is part of the eye.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001873" + }, { + "val" : "CALOHA:TS-0543" + }, { + "val" : "EMAPA:32871" + }, { + "val" : "FMA:58871" + }, { + "val" : "MA:0001301" + }, { + "val" : "SCTID:362523006" + }, { + "val" : "TAO:0001326" + }, { + "val" : "Wikipedia:Lens_(anatomy)#Lens_Epithelium" + }, { + "val" : "XAO:0004094" + }, { + "val" : "ZFA:0001326" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001804", + "lbl" : "capsule of lens", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The elastic, clear, membrane-like structure, that is outer most layer of the lens.", + "xrefs" : [ "MGI:smb", "MP:0003236", "PMID:15483628" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000977" + }, { + "val" : "EMAPA:18237" + }, { + "val" : "FMA:58881" + }, { + "val" : "MA:0001300" + }, { + "val" : "NCIT:C32975" + }, { + "val" : "SCTID:244500004" + }, { + "val" : "VHOG:0000550" + }, { + "val" : "Wikipedia:Lens_(anatomy)#Lens_capsule" + }, { + "val" : "ZFA:0005574" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001805", + "lbl" : "autonomic ganglion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion.", + "xrefs" : [ "Wikipedia:Autonomic_ganglion" ] + }, + "xrefs" : [ { + "val" : "AEO:0001001" + }, { + "val" : "CALOHA:TS-2340" + }, { + "val" : "EMAPA:18221" + }, { + "val" : "FMA:5889" + }, { + "val" : "MA:0000220" + }, { + "val" : "MESH:D005725" + }, { + "val" : "NCIT:C12720" + }, { + "val" : "Wikipedia:Autonomic_ganglion" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001806", + "lbl" : "sympathetic ganglion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.", + "xrefs" : [ "MP:0001008", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010773" + }, { + "val" : "BTO:0001333" + }, { + "val" : "CALOHA:TS-0994" + }, { + "val" : "EHDAA2:0001969" + }, { + "val" : "EMAPA:17157" + }, { + "val" : "FMA:5890" + }, { + "val" : "MA:0000226" + }, { + "val" : "NCIT:C12467" + }, { + "val" : "SCTID:362485003" + }, { + "val" : "Wikipedia:Sympathetic_ganglion" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001833", + "lbl" : "lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the two fleshy folds which surround the opening of the mouth.", + "xrefs" : [ "Wikipedia:Lip", "http://www.medterms.com/script/main/art.asp?articlekey=9458" ] + }, + "xrefs" : [ { + "val" : "BTO:0001647" + }, { + "val" : "CALOHA:TS-0558" + }, { + "val" : "EMAPA:32839" + }, { + "val" : "FMA:59816" + }, { + "val" : "GAID:76" + }, { + "val" : "MA:0000343" + }, { + "val" : "MESH:D008046" + }, { + "val" : "NCIT:C12220" + }, { + "val" : "SCTID:181221003" + }, { + "val" : "TAO:0007006" + }, { + "val" : "VHOG:0000677" + }, { + "val" : "Wikipedia:Lip" + }, { + "val" : "ZFA:0007006" + }, { + "val" : "galen:Lip" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001834", + "lbl" : "upper lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lip that covers the upper portion of the mouth.[TAO].", + "xrefs" : [ "TAO:0001970", "Wikipedia:Upper_lip" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17925" + }, { + "val" : "FMA:59817" + }, { + "val" : "MA:0000919" + }, { + "val" : "SCTID:245776003" + }, { + "val" : "TAO:0001970" + }, { + "val" : "VHOG:0001750" + }, { + "val" : "Wikipedia:Upper_lip" + }, { + "val" : "ZFA:0005226" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001835", + "lbl" : "lower lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lip that covers the lower portion of the mouth.[TAO].", + "xrefs" : [ "TAO:0002060", "Wikipedia:Lower_lip" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17909" + }, { + "val" : "FMA:59818" + }, { + "val" : "MA:0000921" + }, { + "val" : "NCIT:C94572" + }, { + "val" : "SCTID:245777007" + }, { + "val" : "TAO:0002060" + }, { + "val" : "Wikipedia:Lower_lip" + }, { + "val" : "ZFA:0005225" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001884", + "lbl" : "phrenic nerve", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium.", + "xrefs" : [ "VHOG:0000728" ] + }, + "xrefs" : [ { + "val" : "BAMS:phn" + }, { + "val" : "BTO:0001063" + }, { + "val" : "EHDAA:4677" + }, { + "val" : "EMAPA:17813" + }, { + "val" : "FMA:6191" + }, { + "val" : "GAID:848" + }, { + "val" : "MA:0001170" + }, { + "val" : "MESH:D010791" + }, { + "val" : "NCIT:C52813" + }, { + "val" : "SCTID:280344009" + }, { + "val" : "VHOG:0000728" + }, { + "val" : "Wikipedia:Phrenic_nerve" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001891", + "lbl" : "midbrain", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO].", + "xrefs" : [ "GO:0030901" ] + }, + "xrefs" : [ { + "val" : "AAO:0010149" + }, { + "val" : "BAMS:MES" + }, { + "val" : "BIRNLEX:1667" + }, { + "val" : "BM:MB" + }, { + "val" : "BTO:0000138" + }, { + "val" : "CALOHA:TS-0630" + }, { + "val" : "DHBA:10648" + }, { + "val" : "DMBA:16649" + }, { + "val" : "EFO:0000919" + }, { + "val" : "EHDAA2:0001162" + }, { + "val" : "EHDAA:3694" + }, { + "val" : "EMAPA:16974" + }, { + "val" : "EV:0100242" + }, { + "val" : "FMA:61993" + }, { + "val" : "HBA:9001" + }, { + "val" : "MA:0000207" + }, { + "val" : "MAT:0000106" + }, { + "val" : "MBA:313" + }, { + "val" : "MESH:D008636" + }, { + "val" : "MIAA:0000106" + }, { + "val" : "NCIT:C12510" + }, { + "val" : "RETIRED_EHDAA2:0001104" + }, { + "val" : "SCTID:279099009" + }, { + "val" : "TAO:0000128" + }, { + "val" : "VHOG:0000069" + }, { + "val" : "Wikipedia:Midbrain" + }, { + "val" : "XAO:0000014" + }, { + "val" : "ZFA:0000128" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001892", + "lbl" : "rhombomere", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP].", + "xrefs" : [ "Wikipedia:Rhombomere", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "DHBA:12664" + }, { + "val" : "EFO:0003617" + }, { + "val" : "EMAPA:16148" + }, { + "val" : "FMA:295666" + }, { + "val" : "MAT:0000272" + }, { + "val" : "MIAA:0000272" + }, { + "val" : "RETIRED_EHDAA2:0000669" + }, { + "val" : "TAO:0001064" + }, { + "val" : "VHOG:0000672" + }, { + "val" : "Wikipedia:Rhombomere" + }, { + "val" : "XAO:0004079" + }, { + "val" : "ZFA:0001064" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001895", + "lbl" : "metencephalon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified].", + "xrefs" : [ "Wikipedia:Metencephalon", "https://github.com/obophenotype/uberon/issues/300" ] + }, + "comments" : [ "the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]." ], + "xrefs" : [ { + "val" : "BAMS:Met" + }, { + "val" : "BIRNLEX:965" + }, { + "val" : "BTO:0000673" + }, { + "val" : "CALOHA:TS-2029" + }, { + "val" : "DHBA:10655" + }, { + "val" : "EHDAA2:0001149" + }, { + "val" : "EHDAA:5498" + }, { + "val" : "EMAPA:17071" + }, { + "val" : "FMA:62003" + }, { + "val" : "GAID:594" + }, { + "val" : "HBA:4833" + }, { + "val" : "MA:0000197" + }, { + "val" : "MESH:D020540" + }, { + "val" : "NCIT:C32741" + }, { + "val" : "VHOG:0000741" + }, { + "val" : "Wikipedia:Metencephalon" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001896", + "lbl" : "medulla oblongata", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO].", + "xrefs" : [ "FMA:62004", "GO:0021550", "Wikipedia:Bone_marrow_of_ovary_oblongata" ] + }, + "xrefs" : [ { + "val" : "AAO:0010486" + }, { + "val" : "BAMS:MY" + }, { + "val" : "BAMS:Md" + }, { + "val" : "BIRNLEX:957" + }, { + "val" : "BM:Me" + }, { + "val" : "BTO:0000041" + }, { + "val" : "CALOHA:TS-0607" + }, { + "val" : "DMBA:17352" + }, { + "val" : "EFO:0000924" + }, { + "val" : "EHDAA2:0001088" + }, { + "val" : "EHDAA:7588" + }, { + "val" : "EMAPA:17550" + }, { + "val" : "EV:0100275" + }, { + "val" : "FMA:62004" + }, { + "val" : "GAID:590" + }, { + "val" : "MA:0000206" + }, { + "val" : "MAT:0000111" + }, { + "val" : "MAT:0000367" + }, { + "val" : "MBA:354" + }, { + "val" : "MESH:D008526" + }, { + "val" : "MIAA:0000111" + }, { + "val" : "NCIT:C12442" + }, { + "val" : "SCTID:279104005" + }, { + "val" : "TAO:0000545" + }, { + "val" : "VHOG:0000181" + }, { + "val" : "Wikipedia:Bone_marrow_of_ovary_oblongata" + }, { + "val" : "XAO:0003100" + }, { + "val" : "ZFA:0000545" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001901", + "lbl" : "epithelium of trachea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial lining of the trachea which contains numerous ciliated cells.", + "xrefs" : [ "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002285" ] + }, + "xrefs" : [ { + "val" : "BTO:0001389" + }, { + "val" : "CALOHA:TS-1061" + }, { + "val" : "EHDAA2:0002069" + }, { + "val" : "EHDAA:5007" + }, { + "val" : "EMAPA:16855" + }, { + "val" : "EMAPA:18409" + }, { + "val" : "FMA:62015" + }, { + "val" : "MA:0001862" + }, { + "val" : "NCIT:C33797" + }, { + "val" : "VHOG:0001045" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001902", + "lbl" : "epithelium of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a small intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001258" + }, { + "val" : "CALOHA:TS-2104" + }, { + "val" : "EMAPA:35778" + }, { + "val" : "FMA:62017" + }, { + "val" : "MA:0001553" + }, { + "val" : "SCTID:45480009" + }, { + "val" : "TAO:0005127" + }, { + "val" : "ZFA:0005127" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001915", + "lbl" : "endothelium of capillary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a capillary [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004954" + }, { + "val" : "CALOHA:TS-0112" + }, { + "val" : "EMAPA:36292" + }, { + "val" : "FMA:62114" + }, { + "val" : "MA:0000711" + }, { + "val" : "NCIT:C49215" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001916", + "lbl" : "endothelium of arteriole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of an arteriole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36286" + }, { + "val" : "FMA:62115" + }, { + "val" : "MA:0000705" + }, { + "val" : "NCIT:C49192" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001917", + "lbl" : "endothelium of artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of an artery [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0011013" + }, { + "val" : "BTO:0004757" + }, { + "val" : "EMAPA:35148" + }, { + "val" : "FMA:62116" + }, { + "val" : "MA:0000707" + }, { + "val" : "NCIT:C49194" + }, { + "val" : "VHOG:0001215" + }, { + "val" : "XAO:0000357" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001918", + "lbl" : "endothelium of venule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a venule [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36290" + }, { + "val" : "FMA:62117" + }, { + "val" : "MA:0000716" + }, { + "val" : "NCIT:C49319" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001919", + "lbl" : "endothelium of vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a vein [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0011110" + }, { + "val" : "BTO:0004756" + }, { + "val" : "EMAPA:36288" + }, { + "val" : "FMA:62118" + }, { + "val" : "MA:0000712" + }, { + "val" : "NCIT:C49317" + }, { + "val" : "VHOG:0001216" + }, { + "val" : "XAO:0000358" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001943", + "lbl" : "midbrain tegmentum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP].", + "xrefs" : [ "FMA:FMA", "ISBN:0471888893", "Wikipedia:Midbrain_tegmentum" ] + }, + "comments" : [ "'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum" ], + "xrefs" : [ { + "val" : "BAMS:MTg" + }, { + "val" : "BIRNLEX:1200" + }, { + "val" : "BTO:0003388" + }, { + "val" : "DHBA:12195" + }, { + "val" : "EFO:0000921" + }, { + "val" : "EHDAA2:0004475" + }, { + "val" : "EMAPA:18215" + }, { + "val" : "FMA:62393" + }, { + "val" : "HBA:9002" + }, { + "val" : "MA:0000212" + }, { + "val" : "MAT:0000452" + }, { + "val" : "SCTID:362392007" + }, { + "val" : "TAO:0000160" + }, { + "val" : "VHOG:0001367" + }, { + "val" : "Wikipedia:Midbrain_tegmentum" + }, { + "val" : "XAO:0004271" + }, { + "val" : "ZFA:0000160" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001948", + "lbl" : "regional part of spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multi-tissue structure that is part of a spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1496" + }, { + "val" : "NCIT:C33969" + }, { + "val" : "SCTID:244437008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001955", + "lbl" : "epithelium of respiratory bronchiole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a respiratory bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35730" + }, { + "val" : "FMA:62498" + }, { + "val" : "MA:0001773" + }, { + "val" : "NCIT:C48943" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001956", + "lbl" : "cartilage of bronchus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP].", + "xrefs" : [ "MP:0010988" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35192" + }, { + "val" : "FMA:62649" + }, { + "val" : "MA:0001835" + }, { + "val" : "NCIT:C49209" + }, { + "val" : "SCTID:278980009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001957", + "lbl" : "submucosa of bronchus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002108" + }, { + "val" : "FMA:62653" + }, { + "val" : "MA:0001837" + }, { + "val" : "NCIT:C49214" + }, { + "val" : "SCTID:85546005" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001958", + "lbl" : "terminal bronchiole epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that lines a terminal bronchiole.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36283" + }, { + "val" : "FMA:62794" + }, { + "val" : "MA:0001774" + }, { + "val" : "NCIT:C33755" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001969", + "lbl" : "blood plasma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The liquid component of blood, in which erythrocytes are suspended.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000131" + }, { + "val" : "CALOHA:TS-0800" + }, { + "val" : "EFO:0001905" + }, { + "val" : "EMAPA:35690" + }, { + "val" : "FMA:62970" + }, { + "val" : "GAID:1178" + }, { + "val" : "MA:0002501" + }, { + "val" : "MAT:0000052" + }, { + "val" : "MESH:D010949" + }, { + "val" : "MIAA:0000052" + }, { + "val" : "NCIT:C13356" + }, { + "val" : "Wikipedia:Blood_plasma" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "lbl" : "bile", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium.", + "xrefs" : [ "DOI:10.1002/cphy.c120027", "Wikipedia:Bile" ] + }, + "xrefs" : [ { + "val" : "BTO:0000121" + }, { + "val" : "CALOHA:TS-1172" + }, { + "val" : "ENVO:02000023" + }, { + "val" : "FMA:62971" + }, { + "val" : "GAID:1157" + }, { + "val" : "MA:0002513" + }, { + "val" : "MESH:D001646" + }, { + "val" : "NCIT:C13192" + }, { + "val" : "Wikipedia:Bile" + }, { + "val" : "ZFA:0005857" + }, { + "val" : "galen:Bile" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001971", + "lbl" : "gastric juice", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0000501" + }, { + "val" : "FMA:62972" + }, { + "val" : "GAID:1160" + }, { + "val" : "MA:0002519" + }, { + "val" : "MESH:D005750" + }, { + "val" : "NCIT:C32661" + }, { + "val" : "Wikipedia:Gastric_juice" + }, { + "val" : "galen:GastricJuice" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001972", + "lbl" : "submucosa of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002109" + }, { + "val" : "EMAPA:35325" + }, { + "val" : "FMA:62997" + }, { + "val" : "MA:0002724" + }, { + "val" : "SCTID:362128009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001974", + "lbl" : "lamina propria of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26987" + }, { + "val" : "FMA:63050" + }, { + "val" : "MA:0001568" + }, { + "val" : "NCIT:C49223" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001975", + "lbl" : "serosa of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35322" + }, { + "val" : "FMA:63057" + }, { + "val" : "MA:0001571" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001976", + "lbl" : "epithelium of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial layer that lines the luminal space of the esophagus.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0000468" ] + }, + "xrefs" : [ { + "val" : "BTO:0001578" + }, { + "val" : "CALOHA:TS-0698" + }, { + "val" : "EFO:0003041" + }, { + "val" : "EHDAA2:0001287" + }, { + "val" : "EMAPA:16835" + }, { + "val" : "FMA:63063" + }, { + "val" : "MA:0001565" + }, { + "val" : "NCIT:C49221" + }, { + "val" : "TAO:0001499" + }, { + "val" : "ZFA:0001499" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001978", + "lbl" : "parenchyma of pancreas", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:32925" + }, { + "val" : "FMA:63120" + }, { + "val" : "MA:0000724" + }, { + "val" : "SCTID:371401008" + }, { + "val" : "VHOG:0001430" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001979", + "lbl" : "venule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins.", + "xrefs" : [ "MESH:A07.231.432.952", "MP:0004125" ] + }, + "xrefs" : [ { + "val" : "BTO:0002626" + }, { + "val" : "EMAPA:35917" + }, { + "val" : "FMA:63130" + }, { + "val" : "MA:0000071" + }, { + "val" : "MESH:D014699" + }, { + "val" : "NCIT:C12818" + }, { + "val" : "SCTID:341687009" + }, { + "val" : "TAO:0005315" + }, { + "val" : "VHOG:0001765" + }, { + "val" : "Wikipedia:Venule" + }, { + "val" : "ZFA:0005315" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001980", + "lbl" : "arteriole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The smallest division of the artery located between the muscular arteries and the capillaries[GO].", + "xrefs" : [ "GO:0014830" ] + }, + "xrefs" : [ { + "val" : "AAO:0010253" + }, { + "val" : "BTO:0001997" + }, { + "val" : "EMAPA:35146" + }, { + "val" : "FMA:63182" + }, { + "val" : "MA:0000063" + }, { + "val" : "MESH:D001160" + }, { + "val" : "NCIT:C12672" + }, { + "val" : "SCTID:337724002" + }, { + "val" : "TAO:0002138" + }, { + "val" : "VHOG:0001763" + }, { + "val" : "Wikipedia:Arteriole" + }, { + "val" : "ZFA:0005255" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001981", + "lbl" : "blood vessel", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vessel through which blood circulates in the body.", + "xrefs" : [ "BTO:0001102", "Wikipedia:Blood_vessel" ] + }, + "xrefs" : [ { + "val" : "AAO:0011004" + }, { + "val" : "AEO:0000207" + }, { + "val" : "BTO:0001102" + }, { + "val" : "CALOHA:TS-0080" + }, { + "val" : "EFO:0000817" + }, { + "val" : "EHDAA2:0003252" + }, { + "val" : "EHDAA:240" + }, { + "val" : "EMAPA:32743" + }, { + "val" : "EMAPA:35993" + }, { + "val" : "FMA:50722" + }, { + "val" : "FMA:63183" + }, { + "val" : "GAID:169" + }, { + "val" : "MA:0000060" + }, { + "val" : "MAT:0000393" + }, { + "val" : "MESH:D001808" + }, { + "val" : "NCIT:C12679" + }, { + "val" : "NLXANAT:090901" + }, { + "val" : "SCTID:361097006" + }, { + "val" : "TAO:0002137" + }, { + "val" : "VHOG:0001250" + }, { + "val" : "Wikipedia:Blood_vessel" + }, { + "val" : "XAO:0001011" + }, { + "val" : "ZFA:0005314" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001982", + "lbl" : "capillary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the smallest blood vessels connecting arterioles with venules.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Capillary", "https://github.com/obophenotype/uberon/issues/137" ] + }, + "xrefs" : [ { + "val" : "AAO:0010252" + }, { + "val" : "BTO:0002045" + }, { + "val" : "CALOHA:TS-2006" + }, { + "val" : "EFO:0001906" + }, { + "val" : "EMAPA:35198" + }, { + "val" : "EV:0100035" + }, { + "val" : "FMA:63194" + }, { + "val" : "MA:0000065" + }, { + "val" : "MESH:D002196" + }, { + "val" : "NCIT:C12685" + }, { + "val" : "NLXANAT:090902" + }, { + "val" : "TAO:0005250" + }, { + "val" : "VHOG:0001253" + }, { + "val" : "Wikipedia:Capillary" + }, { + "val" : "XAO:0000116" + }, { + "val" : "ZFA:0005250" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001985", + "lbl" : "corneal endothelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP].", + "xrefs" : [ "Wikipedia:Corneal_endothelium" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0172" + }, { + "val" : "EMAPA:35935" + }, { + "val" : "FMA:63882" + }, { + "val" : "GAID:891" + }, { + "val" : "MA:0001242" + }, { + "val" : "MESH:D004728" + }, { + "val" : "NCIT:C12707" + }, { + "val" : "SCTID:368827009" + }, { + "val" : "TAO:0002186" + }, { + "val" : "Wikipedia:Corneal_endothelium" + }, { + "val" : "ZFA:0001687" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001986", + "lbl" : "endothelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA].", + "xrefs" : [ "FMA:63916", "MESH:A10.272.491", "https://github.com/obophenotype/uberon/issues/225" ] + }, + "comments" : [ "The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980)" ], + "xrefs" : [ { + "val" : "BTO:0000393" + }, { + "val" : "CALOHA:TS-0278" + }, { + "val" : "EFO:0002548" + }, { + "val" : "FMA:63916" + }, { + "val" : "GAID:520" + }, { + "val" : "MESH:D004727" + }, { + "val" : "NCIT:C12481" + }, { + "val" : "SCTID:27168002" + }, { + "val" : "galen:Endothelium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001988", + "lbl" : "feces", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of semisolid bodily waste discharged through the anus[MW,modified].", + "xrefs" : [ "Wikipedia:Feces", "http://www.merriam-webster.com/dictionary/feces" ] + }, + "xrefs" : [ { + "val" : "BTO:0000440" + }, { + "val" : "CALOHA:TS-2345" + }, { + "val" : "ENVO:00002003" + }, { + "val" : "FMA:64183" + }, { + "val" : "GAID:1199" + }, { + "val" : "MA:0002509" + }, { + "val" : "MAT:0000053" + }, { + "val" : "MESH:D005243" + }, { + "val" : "MIAA:0000053" + }, { + "val" : "NCIT:C13234" + }, { + "val" : "Wikipedia:Feces" + }, { + "val" : "galen:Feces" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0001994", + "lbl" : "hyaline cartilage tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000094", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35414" + }, { + "val" : "FMA:64783" + }, { + "val" : "MA:0000109" + }, { + "val" : "NCIT:C32746" + }, { + "val" : "SCTID:39298000" + }, { + "val" : "VSAO:0000094" + }, { + "val" : "Wikipedia:Hyaline_cartilage" + }, { + "val" : "XAO:0004029" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002012", + "lbl" : "pulmonary artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood..", + "xrefs" : [ "Wikipedia:Pulmonary_artery", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010221" + }, { + "val" : "BTO:0000778" + }, { + "val" : "CALOHA:TS-0839" + }, { + "val" : "EFO:0001399" + }, { + "val" : "EHDAA2:0001575" + }, { + "val" : "EHDAA:4351" + }, { + "val" : "EMAPA:17008" + }, { + "val" : "FMA:66326" + }, { + "val" : "GAID:505" + }, { + "val" : "MA:0002031" + }, { + "val" : "MESH:D011651" + }, { + "val" : "NCIT:C12774" + }, { + "val" : "SCTID:181380003" + }, { + "val" : "VHOG:0000982" + }, { + "val" : "Wikipedia:Pulmonary_artery" + }, { + "val" : "XAO:0004162" + }, { + "val" : "galen:PulmonaryArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002016", + "lbl" : "pulmonary vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO].", + "xrefs" : [ "GO:0060577" ] + }, + "xrefs" : [ { + "val" : "AAO:0010521" + }, { + "val" : "BTO:0001799" + }, { + "val" : "CALOHA:TS-0840" + }, { + "val" : "EHDAA2:0001579" + }, { + "val" : "EHDAA:2629" + }, { + "val" : "EMAPA:18645" + }, { + "val" : "FMA:66643" + }, { + "val" : "GAID:543" + }, { + "val" : "MA:0002206" + }, { + "val" : "MESH:D011667" + }, { + "val" : "NCIT:C12776" + }, { + "val" : "SCTID:430160002" + }, { + "val" : "VHOG:0001133" + }, { + "val" : "Wikipedia:Pulmonary_vein" + }, { + "val" : "XAO:0000394" + }, { + "val" : "galen:PulmonaryVein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002017", + "lbl" : "portal vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO].", + "xrefs" : [ "BTO:0001792" ] + }, + "xrefs" : [ { + "val" : "BTO:0001792" + }, { + "val" : "CALOHA:TS-0814" + }, { + "val" : "EHDAA2:0001485" + }, { + "val" : "EHDAA:6510" + }, { + "val" : "EMAPA:17349" + }, { + "val" : "FMA:66645" + }, { + "val" : "GAID:540" + }, { + "val" : "MA:0002198" + }, { + "val" : "MESH:D011169" + }, { + "val" : "NCIT:C33343" + }, { + "val" : "SCTID:362064007" + }, { + "val" : "VHOG:0000656" + }, { + "val" : "XAO:0000392" + }, { + "val" : "galen:PortalVein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002020", + "lbl" : "gray matter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons.", + "xrefs" : [ "Wikipedia:Gray_matter", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0001012" + }, { + "val" : "EHDAA2:0003136" + }, { + "val" : "EHDAA2_RETIRED:0004658" + }, { + "val" : "FMA:67242" + }, { + "val" : "HBA:4006" + }, { + "val" : "MA:0001112" + }, { + "val" : "NCIT:C32695" + }, { + "val" : "TAO:0002197" + }, { + "val" : "VHOG:0001768" + }, { + "val" : "Wikipedia:Gray_matter" + }, { + "val" : "ZFA:0001681" + }, { + "val" : "neuronames:2869" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002028", + "lbl" : "hindbrain", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA].", + "xrefs" : [ "Wikipedia:Rhombencephalon", "ZFA:0000029", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0010150" + }, { + "val" : "BAMS:HB" + }, { + "val" : "BIRNLEX:942" + }, { + "val" : "BTO:0000672" + }, { + "val" : "CALOHA:TS-0457" + }, { + "val" : "DHBA:10653" + }, { + "val" : "DMBA:16808" + }, { + "val" : "EFO:0000923" + }, { + "val" : "EHDAA2:0000746" + }, { + "val" : "EHDAA:3514" + }, { + "val" : "EHDAA:6487" + }, { + "val" : "EMAPA:16916" + }, { + "val" : "FMA:67687" + }, { + "val" : "MA:0000195" + }, { + "val" : "MAT:0000107" + }, { + "val" : "MBA:1065" + }, { + "val" : "MESH:D012249" + }, { + "val" : "MIAA:0000107" + }, { + "val" : "NCIT:C40336" + }, { + "val" : "SCTID:303456008" + }, { + "val" : "TAO:0000029" + }, { + "val" : "VHOG:0000070" + }, { + "val" : "Wikipedia:Rhombencephalon" + }, { + "val" : "XAO:0000015" + }, { + "val" : "ZFA:0000029" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "lbl" : "epithelium of gall bladder", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The simple columnar epithelial lining of the gall bladder.", + "xrefs" : [ "MP:0009492" ] + }, + "xrefs" : [ { + "val" : "BTO:0001449" + }, { + "val" : "CALOHA:TS-1304" + }, { + "val" : "EMAPA:35370" + }, { + "val" : "FMA:67711" + }, { + "val" : "MA:0001632" + }, { + "val" : "NCIT:C49227" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002031", + "lbl" : "epithelium of bronchus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001845" + }, { + "val" : "CALOHA:TS-1240" + }, { + "val" : "EFO:0000307" + }, { + "val" : "EMAPA:32691" + }, { + "val" : "FMA:67782" + }, { + "val" : "MA:0001839" + }, { + "val" : "NCIT:C32231" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002036", + "lbl" : "striated muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle tissue that contains fibers that are divided by transverse bands into striations.", + "xrefs" : [ "CL:0000737", "GOC:dph", "GOC:mtg_muscle" ] + }, + "xrefs" : [ { + "val" : "AAO:0010762" + }, { + "val" : "AEO:0000140" + }, { + "val" : "CALOHA:TS-2047" + }, { + "val" : "EHDAA2:0003140" + }, { + "val" : "EMAPA:36390" + }, { + "val" : "FMA:67905" + }, { + "val" : "MA:0002438" + }, { + "val" : "NCIT:C12436" + }, { + "val" : "WBbt:0005779" + }, { + "val" : "Wikipedia:Striated_muscle" + }, { + "val" : "galen:StriatedMuscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002040", + "lbl" : "bronchial artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A systemic artery that supplies the lung with with oxygenated blood.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Bronchial_artery" ] + }, + "comments" : [ "Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung." ], + "xrefs" : [ { + "val" : "EMAPA:18608" + }, { + "val" : "FMA:68109" + }, { + "val" : "GAID:477" + }, { + "val" : "MA:0001923" + }, { + "val" : "MESH:D001981" + }, { + "val" : "NCIT:C32230" + }, { + "val" : "SCTID:244247009" + }, { + "val" : "Wikipedia:Bronchial_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002047", + "lbl" : "pontine raphe nucleus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Pontine_raphe_nucleus" ] + }, + "xrefs" : [ { + "val" : "BAMS:PnR" + }, { + "val" : "BAMS:RA-PONS" + }, { + "val" : "BAMS:RPn" + }, { + "val" : "BIRNLEX:1110" + }, { + "val" : "DHBA:12471" + }, { + "val" : "DHBA:12475" + }, { + "val" : "FMA:68875" + }, { + "val" : "HBA:9159" + }, { + "val" : "MA:0001022" + }, { + "val" : "MBA:238" + }, { + "val" : "Wikipedia:Pontine_raphe_nucleus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002048", + "lbl" : "lung", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Respiration organ that develops as an outpocketing of the esophagus.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP]" ], + "xrefs" : [ { + "val" : "AAO:0000275" + }, { + "val" : "AAO:0010567" + }, { + "val" : "BTO:0000763" + }, { + "val" : "CALOHA:TS-0568" + }, { + "val" : "EFO:0000934" + }, { + "val" : "EHDAA2:0001042" + }, { + "val" : "EHDAA:1554" + }, { + "val" : "EHDAA:2205" + }, { + "val" : "EMAPA:16728" + }, { + "val" : "EV:0100042" + }, { + "val" : "FMA:7195" + }, { + "val" : "GAID:345" + }, { + "val" : "MA:0000415" + }, { + "val" : "MAT:0000135" + }, { + "val" : "MESH:D008168" + }, { + "val" : "MIAA:0000135" + }, { + "val" : "NCIT:C12468" + }, { + "val" : "SCTID:181216001" + }, { + "val" : "Wikipedia:Lung" + }, { + "val" : "XAO:0000119" + }, { + "val" : "galen:Lung" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002049", + "lbl" : "vasculature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face.", + "xrefs" : [ "ZFA:0005249" ] + }, + "xrefs" : [ { + "val" : "BTO:0003718" + }, { + "val" : "FMA:69050" + }, { + "val" : "TAO:0005249" + }, { + "val" : "ZFA:0005249" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002050", + "lbl" : "embryonic structure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that is part of an embryo.", + "xrefs" : [ "BTO:0000174", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0000138" + }, { + "val" : "BILA:0000034" + }, { + "val" : "BTO:0000174" + }, { + "val" : "CALOHA:TS-2110" + }, { + "val" : "EFO:0000461" + }, { + "val" : "FMA:69067" + }, { + "val" : "GAID:407" + }, { + "val" : "MESH:D004628" + }, { + "val" : "NCIT:C13229" + }, { + "val" : "RETIRED_EHDAA2:0003169" + }, { + "val" : "SCTID:667009" + }, { + "val" : "TAO:0001105" + }, { + "val" : "VSAO:0000178" + }, { + "val" : "XAO:0003042" + }, { + "val" : "ZFA:0001105" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002051", + "lbl" : "epithelium of bronchiole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001866" + }, { + "val" : "CALOHA:TS-0570" + }, { + "val" : "EMAPA:32693" + }, { + "val" : "FMA:69077" + }, { + "val" : "MA:0001772" + }, { + "val" : "NCIT:C48942" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002057", + "lbl" : "phrenic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that supplies the diaphragm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:69330" + }, { + "val" : "MA:0002019" + }, { + "val" : "NCIT:C33320" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002061", + "lbl" : "truncus arteriosus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles.", + "xrefs" : [ "Wikipedia:Truncus_arteriosus_(embryology)" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004143" + }, { + "val" : "EMAPA:35887" + }, { + "val" : "FMA:70301" + }, { + "val" : "GAID:554" + }, { + "val" : "MA:0000103" + }, { + "val" : "MESH:D014338" + }, { + "val" : "NCIT:C34317" + }, { + "val" : "SCTID:308828009" + }, { + "val" : "Wikipedia:Truncus_arteriosus_(embryology)" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002062", + "lbl" : "endocardial cushion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA].", + "xrefs" : [ "GO:0003197", "Wikipedia:Atrioventricular_cushions", "ZFIN:curator" ] + }, + "comments" : [ "GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form" ], + "xrefs" : [ { + "val" : "EHDAA2:0000434" + }, { + "val" : "EHDAA2:0004028" + }, { + "val" : "EHDAA:2586" + }, { + "val" : "EMAPA:16696" + }, { + "val" : "FMA:70302" + }, { + "val" : "MA:0000078" + }, { + "val" : "TAO:0001317" + }, { + "val" : "VHOG:0000932" + }, { + "val" : "Wikipedia:Atrioventricular_cushions" + }, { + "val" : "XAO:0004189" + }, { + "val" : "ZFA:0001317" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002063", + "lbl" : "sinus venosus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart.", + "xrefs" : [ "PMID:20735616", "Wikipedia:Sinus_venosus" ] + }, + "xrefs" : [ { + "val" : "AAO:0010505" + }, { + "val" : "EHDAA2:0001839" + }, { + "val" : "EHDAA:480" + }, { + "val" : "EMAPA:16237" + }, { + "val" : "FMA:70303" + }, { + "val" : "NCIT:C34299" + }, { + "val" : "NCIT:C34300" + }, { + "val" : "TAO:0000154" + }, { + "val" : "VHOG:0000177" + }, { + "val" : "Wikipedia:Sinus_venosus" + }, { + "val" : "ZFA:0000154" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002067", + "lbl" : "dermis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP].", + "xrefs" : [ "Wikipedia:Dermis", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0000128" + }, { + "val" : "BTO:0000294" + }, { + "val" : "CALOHA:TS-2076" + }, { + "val" : "EFO:0000953" + }, { + "val" : "EMAPA:17527" + }, { + "val" : "EV:0100154" + }, { + "val" : "FMA:70323" + }, { + "val" : "GAID:1321" + }, { + "val" : "MA:0000152" + }, { + "val" : "MAT:0000153" + }, { + "val" : "MESH:D020405" + }, { + "val" : "MIAA:0000153" + }, { + "val" : "NCIT:C12701" + }, { + "val" : "SCTID:361696001" + }, { + "val" : "TAO:0001119" + }, { + "val" : "VHOG:0000108" + }, { + "val" : "Wikipedia:Dermis" + }, { + "val" : "XAO:0000217" + }, { + "val" : "ZFA:0001119" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002072", + "lbl" : "hypodermis", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP].", + "xrefs" : [ "Wikipedia:Hypodermis" ] + }, + "xrefs" : [ { + "val" : "BTO:0001314" + }, { + "val" : "CALOHA:TS-2366" + }, { + "val" : "FMA:70544" + }, { + "val" : "NCIT:C33645" + }, { + "val" : "TAO:0001136" + }, { + "val" : "Wikipedia:Hypodermis" + }, { + "val" : "ZFA:0001136" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002075", + "lbl" : "viscus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen.", + "xrefs" : [ "BTO:0001491", "Wikipedia:Viscus", "https://github.com/obophenotype/mouse-anatomy-ontology/issues/14" ] + }, + "xrefs" : [ { + "val" : "AAO:0010386" + }, { + "val" : "BTO:0001491" + }, { + "val" : "EHDAA:512" + }, { + "val" : "EMAPA:16245" + }, { + "val" : "FMA:7085" + }, { + "val" : "MA:0000019" + }, { + "val" : "MESH:D014781" + }, { + "val" : "NCIT:C28287" + }, { + "val" : "RETIRED_EHDAA2:0002201" + }, { + "val" : "SCTID:118760003" + }, { + "val" : "Wikipedia:Viscus" + }, { + "val" : "XAO:0003034" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002078", + "lbl" : "right cardiac atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve.", + "xrefs" : [ "Wikipedia:Right_atrium", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010248" + }, { + "val" : "BTO:0001703" + }, { + "val" : "EHDAA2:0000290" + }, { + "val" : "EMAPA:17321" + }, { + "val" : "FMA:7096" + }, { + "val" : "MA:0000075" + }, { + "val" : "NCIT:C12868" + }, { + "val" : "SCTID:244383003" + }, { + "val" : "VHOG:0000328" + }, { + "val" : "Wikipedia:Right_atrium" + }, { + "val" : "XAO:0003192" + }, { + "val" : "galen:RightAtrium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002079", + "lbl" : "left cardiac atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve.", + "xrefs" : [ "Wikipedia:Left_atrium", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010247" + }, { + "val" : "BTO:0001702" + }, { + "val" : "EHDAA2:0000275" + }, { + "val" : "EMAPA:17315" + }, { + "val" : "FMA:7097" + }, { + "val" : "MA:0000074" + }, { + "val" : "NCIT:C12869" + }, { + "val" : "SCTID:244387002" + }, { + "val" : "VHOG:0000369" + }, { + "val" : "Wikipedia:Left_atrium" + }, { + "val" : "XAO:0003191" + }, { + "val" : "galen:LeftAtrium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002080", + "lbl" : "heart right ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac ventricle that is in the right side of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001630" + }, { + "val" : "CALOHA:TS-0443" + }, { + "val" : "EHDAA2:0000196" + }, { + "val" : "EMAPA:17340" + }, { + "val" : "FMA:7098" + }, { + "val" : "MA:0000093" + }, { + "val" : "NCIT:C12870" + }, { + "val" : "SCTID:244384009" + }, { + "val" : "VHOG:0000717" + }, { + "val" : "Wikipedia:Right_ventricle" + }, { + "val" : "galen:RightVentricle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002081", + "lbl" : "cardiac atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cardiac chamber in which blood enters the heart.", + "xrefs" : [ "Wikipedia:Heart_atrium", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010246" + }, { + "val" : "BTO:0000903" + }, { + "val" : "CALOHA:TS-0437" + }, { + "val" : "EFO:0000277" + }, { + "val" : "EHDAA2:0000154" + }, { + "val" : "EHDAA:1265" + }, { + "val" : "EMAPA:16688" + }, { + "val" : "EV:0100019" + }, { + "val" : "FMA:7099" + }, { + "val" : "GAID:555" + }, { + "val" : "MA:0000073" + }, { + "val" : "MAT:0000496" + }, { + "val" : "MESH:D006325" + }, { + "val" : "NCIT:C12728" + }, { + "val" : "SCTID:261405004" + }, { + "val" : "TAO:0000471" + }, { + "val" : "VHOG:0000175" + }, { + "val" : "Wikipedia:Heart_atrium" + }, { + "val" : "ZFA:0000471" + }, { + "val" : "galen:Atrium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002082", + "lbl" : "cardiac ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cardiac chamber through which blood leaves the heart.", + "xrefs" : [ "Wikipedia:Ventricle_(heart)", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010249" + }, { + "val" : "BTO:0000862" + }, { + "val" : "CALOHA:TS-0444" + }, { + "val" : "EFO:0000317" + }, { + "val" : "EHDAA2:0004164" + }, { + "val" : "EHDAA:1912" + }, { + "val" : "EMAPA:17331" + }, { + "val" : "EV:0100020" + }, { + "val" : "FMA:7100" + }, { + "val" : "GAID:568" + }, { + "val" : "MA:0000091" + }, { + "val" : "MAT:0000497" + }, { + "val" : "MESH:D006352" + }, { + "val" : "NCIT:C12730" + }, { + "val" : "SCTID:277699000" + }, { + "val" : "TAO:0000009" + }, { + "val" : "VHOG:0000435" + }, { + "val" : "Wikipedia:Ventricle_(heart)" + }, { + "val" : "XAO:0003193" + }, { + "val" : "ZFA:0000009" + }, { + "val" : "galen:Ventricle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002084", + "lbl" : "heart left ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac ventricle that is in the left side of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001629" + }, { + "val" : "CALOHA:TS-0439" + }, { + "val" : "EHDAA2:0002178" + }, { + "val" : "EMAPA:17337" + }, { + "val" : "FMA:7101" + }, { + "val" : "MA:0000092" + }, { + "val" : "NCIT:C12871" + }, { + "val" : "SCTID:244385005" + }, { + "val" : "VHOG:0000718" + }, { + "val" : "Wikipedia:Left_ventricle" + }, { + "val" : "galen:LeftVentricle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002085", + "lbl" : "interatrial septum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac septum that divides the left and right atria of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000838" + }, { + "val" : "EHDAA:1896" + }, { + "val" : "EMAPA:17011" + }, { + "val" : "FMA:7108" + }, { + "val" : "MA:0000084" + }, { + "val" : "NCIT:C32818" + }, { + "val" : "SCTID:362016003" + }, { + "val" : "VHOG:0000385" + }, { + "val" : "Wikipedia:Interatrial_septum" + }, { + "val" : "galen:InteratrialSeptum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002090", + "lbl" : "postcranial axial skeleton", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA].", + "xrefs" : [ "ZFA:0000317", "https://sourceforge.net/tracker/?func=detail&aid=2983975&group_id=76834&atid=974957", "https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=2983977&group_id=76834" ] + }, + "comments" : [ "previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed." ], + "xrefs" : [ { + "val" : "AAO:0000034" + }, { + "val" : "EFO:0000942" + }, { + "val" : "EHDAA2:0000161" + }, { + "val" : "EHDAA:5049" + }, { + "val" : "FMA:71221" + }, { + "val" : "MA:0002986" + }, { + "val" : "MAT:0000148" + }, { + "val" : "MIAA:0000148" + }, { + "val" : "TAO:0000317" + }, { + "val" : "VHOG:0000317" + }, { + "val" : "VSAO:0000093" + }, { + "val" : "XAO:0003073" + }, { + "val" : "ZFA:0000317" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002091", + "lbl" : "appendicular skeleton", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm].", + "xrefs" : [ "UBERONREF:0000003", "Wikipedia:Appendicular_skeleton", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000747" + }, { + "val" : "EFO:0000951" + }, { + "val" : "EMAPA:32729" + }, { + "val" : "FMA:71222" + }, { + "val" : "MA:0000290" + }, { + "val" : "MAT:0000278" + }, { + "val" : "MIAA:0000278" + }, { + "val" : "NCIT:C49477" + }, { + "val" : "SCTID:322050006" + }, { + "val" : "VSAO:0000076" + }, { + "val" : "Wikipedia:Appendicular_skeleton" + }, { + "val" : "XAO:0003166" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002094", + "lbl" : "interventricular septum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cardiac septum which separates the right ventricle from the left ventricle.[FMA].", + "xrefs" : [ "FMA:7133" ] + }, + "xrefs" : [ { + "val" : "BTO:0002483" + }, { + "val" : "EFO:0001956" + }, { + "val" : "EHDAA:2603" + }, { + "val" : "EMAPA:17333" + }, { + "val" : "FMA:7133" + }, { + "val" : "MA:0000085" + }, { + "val" : "NCIT:C32874" + }, { + "val" : "SCTID:362019005" + }, { + "val" : "VHOG:0000386" + }, { + "val" : "Wikipedia:Interventricular_septum" + }, { + "val" : "galen:InterventricularSeptum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002095", + "lbl" : "mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon.", + "xrefs" : [ "FMA:7144", "Wikipedia:Mesentery", "Wikipedia:Mesentery#Mesentery_.28general.29", "https://github.com/obophenotype/uberon/issues/85" ] + }, + "xrefs" : [ { + "val" : "AAO:0011061" + }, { + "val" : "BTO:0001380" + }, { + "val" : "EV:0100083" + }, { + "val" : "FMA:7144" + }, { + "val" : "GAID:21" + }, { + "val" : "MESH:D008643" + }, { + "val" : "NCIT:C33103" + }, { + "val" : "SCTID:362707009" + }, { + "val" : "Wikipedia:Mesentery#Mesentery_.28general.29" + }, { + "val" : "galen:Mesentery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002097", + "lbl" : "skin of body", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The organ covering the body that consists of the dermis and epidermis.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "BTO:0001253" + }, { + "val" : "CALOHA:TS-0934" + }, { + "val" : "EFO:0000962" + }, { + "val" : "EHDAA2:0001844" + }, { + "val" : "EMAPA:17525" + }, { + "val" : "FMA:7163" + }, { + "val" : "MESH:D012867" + }, { + "val" : "MFMO:0000099" + }, { + "val" : "NCIT:C12470" + }, { + "val" : "SCTID:181469002" + }, { + "val" : "Wikipedia:Skin" + }, { + "val" : "XAO:0000023" + }, { + "val" : "galen:Skin" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002099", + "lbl" : "cardiac septum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles.", + "xrefs" : [ "MESH:A07.541.459" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35400" + }, { + "val" : "FMA:7180" + }, { + "val" : "GAID:562" + }, { + "val" : "MA:0000083" + }, { + "val" : "MESH:D006346" + }, { + "val" : "NCIT:C49485" + }, { + "val" : "SCTID:362014000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002100", + "lbl" : "trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.", + "xrefs" : [ "TAO:0001115", "UBERONREF:0000006", "Wikipedia:Torso" ] + }, + "xrefs" : [ { + "val" : "AAO:0010339" + }, { + "val" : "BILA:0000116" + }, { + "val" : "BTO:0001493" + }, { + "val" : "CALOHA:TS-1071" + }, { + "val" : "EFO:0000966" + }, { + "val" : "EMAPA:31857" + }, { + "val" : "FMA:7181" + }, { + "val" : "MA:0000004" + }, { + "val" : "MAT:0000296" + }, { + "val" : "MIAA:0000296" + }, { + "val" : "NCIT:C33816" + }, { + "val" : "SCTID:262225004" + }, { + "val" : "TAO:0001115" + }, { + "val" : "Wikipedia:Torso" + }, { + "val" : "XAO:0000054" + }, { + "val" : "XAO:0003025" + }, { + "val" : "ZFA:0001115" + }, { + "val" : "galen:Trunk" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002104", + "lbl" : "visual system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sensory system subserving the sense of vision.", + "xrefs" : [ "NIFSTD:FMAID_7191" ] + }, + "xrefs" : [ { + "val" : "AAO:0000632" + }, { + "val" : "BILA:0000140" + }, { + "val" : "EMAPA:36003" + }, { + "val" : "FMA:7191" + }, { + "val" : "MA:0002444" + }, { + "val" : "NCIT:C12888" + }, { + "val" : "SCTID:281831001" + }, { + "val" : "TAO:0001127" + }, { + "val" : "Wikipedia:Visual_system" + }, { + "val" : "XAO:0003198" + }, { + "val" : "ZFA:0001127" + }, { + "val" : "http://uri.neuinfo.org/nif/nifstd/FMAID_7191" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002105", + "lbl" : "vestibulo-auditory system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Sensory system responsible for the perception of spatial orientation and auditory stimuli.", + "xrefs" : [ "ZFA:0001138" ] + }, + "xrefs" : [ { + "val" : "AAO:0000631" + }, { + "val" : "FMA:78500" + }, { + "val" : "TAO:0001138" + }, { + "val" : "XAO:0003195" + }, { + "val" : "ZFA:0001138" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "lbl" : "spleen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The organ that functions to filter blood and to store red corpuscles and platelets.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0000689" ] + }, + "xrefs" : [ { + "val" : "AAO:0010395" + }, { + "val" : "BTO:0001281" + }, { + "val" : "CALOHA:TS-0956" + }, { + "val" : "EFO:0000869" + }, { + "val" : "EMAPA:18767" + }, { + "val" : "EV:0100055" + }, { + "val" : "FMA:7196" + }, { + "val" : "GAID:1289" + }, { + "val" : "MA:0000141" + }, { + "val" : "MAT:0000085" + }, { + "val" : "MESH:D013154" + }, { + "val" : "MIAA:0000085" + }, { + "val" : "NCIT:C12432" + }, { + "val" : "SCTID:181279003" + }, { + "val" : "TAO:0000436" + }, { + "val" : "VHOG:0000120" + }, { + "val" : "Wikipedia:Spleen" + }, { + "val" : "XAO:0000328" + }, { + "val" : "ZFA:0000436" + }, { + "val" : "galen:Spleen" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "lbl" : "liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].", + "xrefs" : [ "BTO:0000759", "Wikipedia:Liver" ] + }, + "xrefs" : [ { + "val" : "AAO:0010111" + }, { + "val" : "BTO:0000759" + }, { + "val" : "CALOHA:TS-0564" + }, { + "val" : "EFO:0000887" + }, { + "val" : "EHDAA2:0000997" + }, { + "val" : "EHDAA:2197" + }, { + "val" : "EMAPA:16846" + }, { + "val" : "EV:0100089" + }, { + "val" : "FMA:7197" + }, { + "val" : "GAID:288" + }, { + "val" : "MA:0000358" + }, { + "val" : "MAT:0000097" + }, { + "val" : "MESH:D008099" + }, { + "val" : "MIAA:0000097" + }, { + "val" : "NCIT:C12392" + }, { + "val" : "SCTID:181268008" + }, { + "val" : "TAO:0000123" + }, { + "val" : "VHOG:0000257" + }, { + "val" : "Wikipedia:Liver" + }, { + "val" : "XAO:0000133" + }, { + "val" : "ZFA:0000123" + }, { + "val" : "galen:Liver" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "lbl" : "small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong].", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Small_intestine" ] + }, + "xrefs" : [ { + "val" : "AAO:0010397" + }, { + "val" : "BTO:0000651" + }, { + "val" : "CALOHA:TS-0942" + }, { + "val" : "EFO:0000841" + }, { + "val" : "EMAPA:32834" + }, { + "val" : "EV:0100072" + }, { + "val" : "FMA:7200" + }, { + "val" : "GAID:313" + }, { + "val" : "MA:0000337" + }, { + "val" : "MAT:0000047" + }, { + "val" : "MESH:D007421" + }, { + "val" : "MIAA:0000047" + }, { + "val" : "NCIT:C12386" + }, { + "val" : "SCTID:181250005" + }, { + "val" : "TAO:0001323" + }, { + "val" : "VHOG:0000055" + }, { + "val" : "Wikipedia:Small_intestine" + }, { + "val" : "XAO:0000130" + }, { + "val" : "ZFA:0001323" + }, { + "val" : "galen:SmallIntestine" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "lbl" : "gallbladder", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that aids digestion and stores bile produced by the liver[WP].", + "xrefs" : [ "Wikipedia:Gallbladder" ] + }, + "comments" : [ "Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988)" ], + "xrefs" : [ { + "val" : "AAO:0010114" + }, { + "val" : "BTO:0000493" + }, { + "val" : "CALOHA:TS-0394" + }, { + "val" : "EFO:0000853" + }, { + "val" : "EHDAA2:0000699" + }, { + "val" : "EHDAA:8062" + }, { + "val" : "EMAPA:17202" + }, { + "val" : "EV:0100090" + }, { + "val" : "FMA:7202" + }, { + "val" : "MA:0000356" + }, { + "val" : "MAT:0000072" + }, { + "val" : "MESH:D005704" + }, { + "val" : "MIAA:0000072" + }, { + "val" : "NCIT:C12377" + }, { + "val" : "SCTID:181269000" + }, { + "val" : "TAO:0000208" + }, { + "val" : "VHOG:0000221" + }, { + "val" : "Wikipedia:Gallbladder" + }, { + "val" : "XAO:0000135" + }, { + "val" : "ZFA:0000208" + }, { + "val" : "galen:Gallbladder" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002111", + "lbl" : "artery smooth muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of an artery [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000087" + }, { + "val" : "CALOHA:TS-1198" + }, { + "val" : "EMAPA:36285" + }, { + "val" : "FMA:72024" + }, { + "val" : "MA:0000708" + }, { + "val" : "NCIT:C49195" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002112", + "lbl" : "smooth muscle of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35323" + }, { + "val" : "FMA:72025" + }, { + "val" : "MA:0001573" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "lbl" : "duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one).", + "xrefs" : [ "ISBN:0815318960", "Wikipedia:Duodenum" ] + }, + "xrefs" : [ { + "val" : "AAO:0010402" + }, { + "val" : "BTO:0000365" + }, { + "val" : "CALOHA:TS-0214" + }, { + "val" : "EFO:0000851" + }, { + "val" : "EMAPA:18852" + }, { + "val" : "EV:0100073" + }, { + "val" : "FMA:7206" + }, { + "val" : "GAID:284" + }, { + "val" : "MA:0000338" + }, { + "val" : "MAT:0000044" + }, { + "val" : "MESH:D004386" + }, { + "val" : "MIAA:0000044" + }, { + "val" : "NCIT:C12263" + }, { + "val" : "SCTID:181247007" + }, { + "val" : "VHOG:0000052" + }, { + "val" : "Wikipedia:Duodenum" + }, { + "val" : "XAO:0000236" + }, { + "val" : "galen:Duodenum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002118", + "lbl" : "right ovary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ovary that is part of a right side of organism [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7213" + }, { + "val" : "MA:0001705" + }, { + "val" : "NCIT:C33487" + }, { + "val" : "SCTID:280123002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002119", + "lbl" : "left ovary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ovary that is part of a left side of organism [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7214" + }, { + "val" : "MA:0001704" + }, { + "val" : "NCIT:C32969" + }, { + "val" : "SCTID:280124008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002128", + "lbl" : "superior olivary complex", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system.", + "xrefs" : [ "ISBN:0-19-502694-2", "Wikipedia:Superior_olivary_complex" ] + }, + "xrefs" : [ { + "val" : "BAMS:SOC" + }, { + "val" : "BIRNLEX:1307" + }, { + "val" : "DHBA:12462" + }, { + "val" : "EMAPA:35840" + }, { + "val" : "EV:0100263" + }, { + "val" : "FMA:72247" + }, { + "val" : "HBA:9177" + }, { + "val" : "MA:0001026" + }, { + "val" : "MBA:398" + }, { + "val" : "VHOG:0001381" + }, { + "val" : "Wikipedia:Superior_olivary_complex" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002148", + "lbl" : "locus ceruleus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID].", + "xrefs" : [ "GAID:577", "GO:0021703", "Wikipedia:Locus_ceruleus" ] + }, + "xrefs" : [ { + "val" : "BAMS:CAE" + }, { + "val" : "BAMS:LC" + }, { + "val" : "BIRNLEX:905" + }, { + "val" : "BM:Pons-LC" + }, { + "val" : "BTO:0001408" + }, { + "val" : "DHBA:12819" + }, { + "val" : "DMBA:16972" + }, { + "val" : "EFO:0001963" + }, { + "val" : "EMAPA:35502" + }, { + "val" : "FMA:72478" + }, { + "val" : "GAID:577" + }, { + "val" : "HBA:9148" + }, { + "val" : "MA:0001017" + }, { + "val" : "MBA:147" + }, { + "val" : "MESH:D008125" + }, { + "val" : "NCIT:C97333" + }, { + "val" : "SCTID:369016004" + }, { + "val" : "TAO:0000539" + }, { + "val" : "Wikipedia:Locus_ceruleus" + }, { + "val" : "ZFA:0000539" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002149", + "lbl" : "superior salivatory nucleus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703).", + "xrefs" : [ "BIRNLEX:1131" ] + }, + "xrefs" : [ { + "val" : "BAMS:SSN" + }, { + "val" : "BAMS:SuS" + }, { + "val" : "BIRNLEX:1131" + }, { + "val" : "DHBA:12435" + }, { + "val" : "EHDAA2:0004646" + }, { + "val" : "FMA:72482" + }, { + "val" : "HBA:9194" + }, { + "val" : "MA:0001027" + }, { + "val" : "MBA:462" + }, { + "val" : "SCTID:369028007" + }, { + "val" : "Wikipedia:Superior_salivatory_nucleus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002165", + "lbl" : "endocardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO].", + "xrefs" : [ "GO:0003157" ] + }, + "comments" : [ "fixed in GO to reflect FMA. See email to David/Varsha June 18 2010" ], + "xrefs" : [ { + "val" : "AAO:0010408" + }, { + "val" : "BTO:0000387" + }, { + "val" : "CALOHA:TS-2075" + }, { + "val" : "EFO:0000821" + }, { + "val" : "EHDAA2:0004153" + }, { + "val" : "EMAPA:17868" + }, { + "val" : "EMAPA:32686" + }, { + "val" : "EV:0100021" + }, { + "val" : "FMA:7280" + }, { + "val" : "GAID:550" + }, { + "val" : "MA:0000076" + }, { + "val" : "MAT:0000455" + }, { + "val" : "MESH:D004699" + }, { + "val" : "NCIT:C13004" + }, { + "val" : "SCTID:362013006" + }, { + "val" : "TAO:0001320" + }, { + "val" : "VHOG:0000084" + }, { + "val" : "Wikipedia:Endocardium" + }, { + "val" : "XAO:0000066" + }, { + "val" : "ZFA:0001320" + }, { + "val" : "galen:Endocardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002166", + "lbl" : "endocardium of atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endocardium that is part of the atrium.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32745" + }, { + "val" : "FMA:7284" + }, { + "val" : "MA:0000077" + }, { + "val" : "SCTID:192001005" + }, { + "val" : "TAO:0002169" + }, { + "val" : "VHOG:0000606" + }, { + "val" : "ZFA:0001614" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002167", + "lbl" : "right lung", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA].", + "xrefs" : [ "FMA:FMA", "Wikipedia:Right_lung" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001730" + }, { + "val" : "EHDAA:4969" + }, { + "val" : "EMAPA:17661" + }, { + "val" : "FMA:7309" + }, { + "val" : "MA:0000426" + }, { + "val" : "NCIT:C33483" + }, { + "val" : "SCTID:361967000" + }, { + "val" : "VHOG:0000301" + }, { + "val" : "Wikipedia:Right_lung" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002168", + "lbl" : "left lung", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Lung which consists of the left upper lobe and left lower lobe.[FMA].", + "xrefs" : [ "FMA:FMA", "Wikipedia:Left_lung" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000943" + }, { + "val" : "EHDAA:4947" + }, { + "val" : "EMAPA:17653" + }, { + "val" : "FMA:7310" + }, { + "val" : "MA:0000425" + }, { + "val" : "NCIT:C32967" + }, { + "val" : "SCTID:361982005" + }, { + "val" : "VHOG:0000618" + }, { + "val" : "Wikipedia:Left_lung" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002169", + "lbl" : "alveolar sac", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters.", + "xrefs" : [ "MP:0010902", "Wikipedia:Alveolar_sac" ] + }, + "xrefs" : [ { + "val" : "BTO:0000061" + }, { + "val" : "EMAPA:35119" + }, { + "val" : "FMA:7317" + }, { + "val" : "MA:0000418" + }, { + "val" : "NCIT:C32057" + }, { + "val" : "SCTID:361964007" + }, { + "val" : "Wikipedia:Alveolar_sac" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002173", + "lbl" : "pulmonary alveolar duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:cwg", "MP:0002271" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32694" + }, { + "val" : "FMA:7341" + }, { + "val" : "MA:0000417" + }, { + "val" : "NCIT:C32056" + }, { + "val" : "Wikipedia:Alveolar_duct" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002185", + "lbl" : "bronchus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The upper conducting airways of the lung; these airways arise from the terminus of the trachea.", + "xrefs" : [ "ISBN:0-397-51047-0", "MESH:A04.411.125", "MGI:cwg", "MP:0002264" ] + }, + "xrefs" : [ { + "val" : "BTO:0001340" + }, { + "val" : "CALOHA:TS-1229" + }, { + "val" : "EFO:0000932" + }, { + "val" : "EMAPA:32689" + }, { + "val" : "EV:0100041" + }, { + "val" : "FMA:7409" + }, { + "val" : "GAID:346" + }, { + "val" : "MA:0000436" + }, { + "val" : "MAT:0000133" + }, { + "val" : "MESH:D001980" + }, { + "val" : "MIAA:0000133" + }, { + "val" : "NCIT:C12683" + }, { + "val" : "SCTID:181215002" + }, { + "val" : "VHOG:0000262" + }, { + "val" : "Wikipedia:Bronchus" + }, { + "val" : "XAO:0000121" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002186", + "lbl" : "bronchiole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching.", + "xrefs" : [ "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002267" ] + }, + "comments" : [ "In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole." ], + "xrefs" : [ { + "val" : "BTO:0002375" + }, { + "val" : "CALOHA:TS-2003" + }, { + "val" : "EHDAA:8171" + }, { + "val" : "EHDAA:8183" + }, { + "val" : "EHDAA:8199" + }, { + "val" : "EHDAA:8221" + }, { + "val" : "EMAPA:32697" + }, { + "val" : "FMA:7410" + }, { + "val" : "MA:0000422" + }, { + "val" : "NCIT:C12684" + }, { + "val" : "SCTID:278982001" + }, { + "val" : "VHOG:0000675" + }, { + "val" : "Wikipedia:Bronchiole" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002187", + "lbl" : "terminal bronchiole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls.", + "xrefs" : [ "ISBN:0-397-51047-0", "MGI:cwg", "MP:0002268", "PMID:16543587" ] + }, + "xrefs" : [ { + "val" : "BTO:0003223" + }, { + "val" : "EMAPA:36282" + }, { + "val" : "FMA:7411" + }, { + "val" : "MA:0000424" + }, { + "val" : "NCIT:C33754" + }, { + "val" : "SCTID:278981008" + }, { + "val" : "Wikipedia:Terminal_bronchiole" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002188", + "lbl" : "respiratory bronchiole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bronchiole that is the first segment of the respiratory zone.", + "xrefs" : [ "ISBN:0123813611", "Wikipedia:Respiratory_bronchiole" ] + }, + "xrefs" : [ { + "val" : "BTO:0003222" + }, { + "val" : "EMAPA:35729" + }, { + "val" : "FMA:7412" + }, { + "val" : "MA:0000423" + }, { + "val" : "NCIT:C33465" + }, { + "val" : "SCTID:128517006" + }, { + "val" : "Wikipedia:Respiratory_bronchiole" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002190", + "lbl" : "subcutaneous adipose tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of adipose tissue that is part of the hypodermis, beneath the dermis.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004042" + }, { + "val" : "EMAPA:35829" + }, { + "val" : "FMA:74315" + }, { + "val" : "MA:0000473" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002193", + "lbl" : "hemolymphoid system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2018" + }, { + "val" : "EHDAA2:0004615" + }, { + "val" : "EMAPA:18765" + }, { + "val" : "FMA:74562" + }, { + "val" : "MA:0000013" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002199", + "lbl" : "integument", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dermis, epidermis and hypodermis.", + "xrefs" : [ "Wikipedia:Integument" ] + }, + "xrefs" : [ { + "val" : "AAO:0000239" + }, { + "val" : "BTO:0000634" + }, { + "val" : "FMA:74657" + }, { + "val" : "TAO:0000368" + }, { + "val" : "VSAO:0000029" + }, { + "val" : "Wikipedia:Integument" + }, { + "val" : "ZFA:0000368" + }, { + "val" : "galen:Integument" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002200", + "lbl" : "vasculature of head", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vasculature that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003656" + }, { + "val" : "FMA:74710" + }, { + "val" : "TAO:0001267" + }, { + "val" : "XAO:0004152" + }, { + "val" : "ZFA:0001267" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002201", + "lbl" : "vasculature of trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:74712" + }, { + "val" : "TAO:0005024" + }, { + "val" : "ZFA:0005024" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002202", + "lbl" : "submucosa of trachea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002115" + }, { + "val" : "EMAPA:35879" + }, { + "val" : "FMA:7472" + }, { + "val" : "MA:0001860" + }, { + "val" : "NCIT:C49307" + }, { + "val" : "SCTID:4419000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002203", + "lbl" : "vasculature of eye", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vasculature that is part of the eye region.", + "xrefs" : [ "OBOL:automatic", "https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726" ] + }, + "xrefs" : [ { + "val" : "FMA:74743" + }, { + "val" : "SCTID:123846009" + }, { + "val" : "TAO:0007057" + }, { + "val" : "ZFA:0007057" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002204", + "lbl" : "musculoskeletal system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that consists of the muscular and skeletal systems.", + "xrefs" : [ "VSAO:0000031", "VSAO:curator", "https://github.com/obophenotype/uberon/issues/77" ] + }, + "xrefs" : [ { + "val" : "AAO:0010546" + }, { + "val" : "CALOHA:TS-1311" + }, { + "val" : "EMAPA:32714" + }, { + "val" : "EV:0100139" + }, { + "val" : "FMA:7482" + }, { + "val" : "GAID:98" + }, { + "val" : "MA:0002418" + }, { + "val" : "MESH:D009141" + }, { + "val" : "NCIT:C12754" + }, { + "val" : "SCTID:278858007" + }, { + "val" : "VHOG:0001275" + }, { + "val" : "VSAO:0000031" + }, { + "val" : "Wikipedia:Musculoskeletal_system" + }, { + "val" : "XAO:0000168" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002213", + "lbl" : "cartilaginous joint", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA].", + "xrefs" : [ "FMA:FMA", "Wikipedia:Cartilaginous_joint" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36581" + }, { + "val" : "FMA:7496" + }, { + "val" : "MA:0000320" + }, { + "val" : "SCTID:58442004" + }, { + "val" : "TAO:0005155" + }, { + "val" : "Wikipedia:Cartilaginous_joint" + }, { + "val" : "ZFA:0005155" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002217", + "lbl" : "synovial joint", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA].", + "xrefs" : [ "FMA:7501", "Wikipedia:Synovial_joint" ] + }, + "xrefs" : [ { + "val" : "AEO:0000183" + }, { + "val" : "CALOHA:TS-2138" + }, { + "val" : "EHDAA2:0003183" + }, { + "val" : "FMA:7501" + }, { + "val" : "MA:0000322" + }, { + "val" : "NCIT:C32461" + }, { + "val" : "SCTID:113234001" + }, { + "val" : "TAO:0005153" + }, { + "val" : "Wikipedia:Synovial_joint" + }, { + "val" : "ZFA:0005153" + }, { + "val" : "galen:SynovialJoint" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002224", + "lbl" : "thoracic cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the coelemic cavity lumen that is enclosed by the walls of the thorax.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Thoracic_cavity" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36497" + }, { + "val" : "FMA:7565" + }, { + "val" : "GAID:93" + }, { + "val" : "MA:0000032" + }, { + "val" : "MESH:D035423" + }, { + "val" : "NCIT:C12905" + }, { + "val" : "SCTID:243949006" + }, { + "val" : "Wikipedia:Thoracic_cavity" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002240", + "lbl" : "spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).", + "xrefs" : [ "BIRNLEX:1709" ] + }, + "xrefs" : [ { + "val" : "AAO:0010151" + }, { + "val" : "BAMS:SP" + }, { + "val" : "BAMS:Spinal" + }, { + "val" : "BIRNLEX:1709" + }, { + "val" : "BM:SpC" + }, { + "val" : "BTO:0001279" + }, { + "val" : "CALOHA:TS-0953" + }, { + "val" : "DHBA:12890" + }, { + "val" : "DMBA:17651" + }, { + "val" : "EFO:0000110" + }, { + "val" : "EHDAA2:0001255" + }, { + "val" : "EHDAA:2863" + }, { + "val" : "EMAPA:17577" + }, { + "val" : "EV:0100316" + }, { + "val" : "FMA:7647" + }, { + "val" : "GAID:695" + }, { + "val" : "MA:0000216" + }, { + "val" : "MAT:0000183" + }, { + "val" : "MESH:D013116" + }, { + "val" : "MIAA:0000183" + }, { + "val" : "NCIT:C12464" + }, { + "val" : "SCTID:180959008" + }, { + "val" : "TAO:0000075" + }, { + "val" : "VHOG:0000601" + }, { + "val" : "Wikipedia:Spinal_cord" + }, { + "val" : "XAO:0000020" + }, { + "val" : "ZFA:0000075" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002241", + "lbl" : "chondrocranium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD].", + "xrefs" : [ "Wikipedia:Chondrocranium", "http://medical-dictionary.thefreedictionary.com/chondrocranium" ] + }, + "xrefs" : [ { + "val" : "AAO:0010169" + }, { + "val" : "EHDAA2:0000243" + }, { + "val" : "EMAPA:17681" + }, { + "val" : "TAO:0001424" + }, { + "val" : "VHOG:0000288" + }, { + "val" : "Wikipedia:Chondrocranium" + }, { + "val" : "ZFA:0001424" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002257", + "lbl" : "ventral horn of spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO].", + "xrefs" : [ "GO:0021517", "MP:0005112", "Wikipedia:Anterior_horn_of_spinal_cord", "https://sourceforge.net/tracker/?group_id=36855&atid=440764" ] + }, + "xrefs" : [ { + "val" : "BAMS:VH" + }, { + "val" : "BIRNLEX:2668" + }, { + "val" : "BTO:0005151" + }, { + "val" : "EMAPA:18575" + }, { + "val" : "EMAPA:35794" + }, { + "val" : "FMA:256541" + }, { + "val" : "MA:0001134" + }, { + "val" : "NCIT:C33859" + }, { + "val" : "SCTID:279443000" + }, { + "val" : "TAO:0000702" + }, { + "val" : "VHOG:0001288" + }, { + "val" : "Wikipedia:Anterior_horn_of_spinal_cord" + }, { + "val" : "ZFA:0000702" + }, { + "val" : "neuronames:1751" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002275", + "lbl" : "reticular formation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ).", + "xrefs" : [ "NeuroNames:1223" ] + }, + "xrefs" : [ { + "val" : "BAMS:RET" + }, { + "val" : "EMAPA:35188" + }, { + "val" : "FMA:77719" + }, { + "val" : "MA:0003185" + }, { + "val" : "MESH:D012154" + }, { + "val" : "NLX:143558" + }, { + "val" : "SCTID:361552007" + }, { + "val" : "Wikipedia:Reticular_formation" + }, { + "val" : "neuronames:1223" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "lbl" : "biliary system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree).", + "xrefs" : [ "Wikipedia:Biliary_system" ] + }, + "xrefs" : [ { + "val" : "FMA:79646" + }, { + "val" : "GAID:279" + }, { + "val" : "MA:0001273" + }, { + "val" : "MESH:D001659" + }, { + "val" : "NCIT:C12678" + }, { + "val" : "SCTID:361354009" + }, { + "val" : "Wikipedia:Biliary_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002296", + "lbl" : "dorsal mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA].", + "xrefs" : [ "Wikipedia:Dorsal_mesentery", "Wikipedia:Mesentery#Development", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004560" + }, { + "val" : "EHDAA:3019" + }, { + "val" : "EHDAA:3033" + }, { + "val" : "EHDAA:3921" + }, { + "val" : "EHDAA:3934" + }, { + "val" : "EHDAA:3957" + }, { + "val" : "EHDAA:3971" + }, { + "val" : "FMA:79795" + }, { + "val" : "SCTID:308823000" + }, { + "val" : "TAO:0005130" + }, { + "val" : "Wikipedia:Mesentery#Development" + }, { + "val" : "ZFA:0005130" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002298", + "lbl" : "brainstem", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized].", + "xrefs" : [ "ISBN:0471888893", "MP:0005277", "Wikipedia:Brainstem", "ZFA:0001707" ] + }, + "comments" : [ "'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions)." ], + "xrefs" : [ { + "val" : "BAMS:BS" + }, { + "val" : "BIRNLEX:1565" + }, { + "val" : "BTO:0000146" + }, { + "val" : "CALOHA:TS-0093" + }, { + "val" : "EFO:0001962" + }, { + "val" : "EMAPA:32678" + }, { + "val" : "EV:0100241" + }, { + "val" : "FMA:79876" + }, { + "val" : "MA:0000169" + }, { + "val" : "MBA:343" + }, { + "val" : "MESH:D001933" + }, { + "val" : "NCIT:C12441" + }, { + "val" : "SCTID:180925009" + }, { + "val" : "TAO:0002156" + }, { + "val" : "VHOG:0001457" + }, { + "val" : "Wikipedia:Brainstem" + }, { + "val" : "ZFA:0001707" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002299", + "lbl" : "alveolus of lung", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP].", + "xrefs" : [ "Wikipedia:Pulmonary_alveolus" ] + }, + "xrefs" : [ { + "val" : "BTO:0000060" + }, { + "val" : "CALOHA:TS-0031" + }, { + "val" : "EFO:0001985" + }, { + "val" : "EMAPA:32682" + }, { + "val" : "FMA:7318" + }, { + "val" : "GAID:349" + }, { + "val" : "MA:0000420" + }, { + "val" : "MESH:D011650" + }, { + "val" : "SCTID:361364000" + }, { + "val" : "VHOG:0001445" + }, { + "val" : "Wikipedia:Pulmonary_alveolus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002302", + "lbl" : "myocardium of atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The atrial part of middle layer of the heart, comprised of involuntary muscle.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010493" ] + }, + "xrefs" : [ { + "val" : "EFO:0003087" + }, { + "val" : "EMAPA:32746" + }, { + "val" : "FMA:83509" + }, { + "val" : "MA:0000081" + }, { + "val" : "SCTID:191910002" + }, { + "val" : "TAO:0001374" + }, { + "val" : "VHOG:0000602" + }, { + "val" : "ZFA:0001374" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002308", + "lbl" : "nucleus of brain", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural nucleus that is part of the brain.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35185" + }, { + "val" : "FMA:83840" + }, { + "val" : "MA:0000811" + }, { + "val" : "NCIT:C49346" + }, { + "val" : "SCTID:426465002" + }, { + "val" : "ZFA:0005575" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002315", + "lbl" : "gray matter of spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue.", + "xrefs" : [ "MP:0008503" ] + }, + "xrefs" : [ { + "val" : "BAMS:Scgrey" + }, { + "val" : "DHBA:146035048" + }, { + "val" : "EMAPA:35792" + }, { + "val" : "FMA:256580" + }, { + "val" : "MA:0000002" + }, { + "val" : "NCIT:C32696" + }, { + "val" : "NLXANAT:100204" + }, { + "val" : "SCTID:279441003" + }, { + "val" : "neuronames:2619" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002323", + "lbl" : "coelemic cavity lumen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities.", + "xrefs" : [ "BTO:0001707" ] + }, + "comments" : [ "EDITOR_NOTE check the FMA placement here; ncit placement of body cavity here probably not correct" ], + "xrefs" : [ { + "val" : "AEO:0000186" + }, { + "val" : "BTO:0001707" + }, { + "val" : "EHDAA2:0000267" + }, { + "val" : "FMA:85006" + }, { + "val" : "NCIT:C25444" + }, { + "val" : "RETIRED_EHDAA2:0003186" + }, { + "val" : "SCTID:361348008" + }, { + "val" : "TAO:0001438" + }, { + "val" : "ZFA:0001438" + }, { + "val" : "galen:BodyCavity" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002324", + "lbl" : "muscle of back", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35161" + }, { + "val" : "FMA:85216" + }, { + "val" : "MA:0000496" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002328", + "lbl" : "notochord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube.", + "xrefs" : [ "ISBN:0815318960", "Wikipedia:Notochord", "http://tolweb.org/Chordata/2499", "https://github.com/obophenotype/uberon/issues/25", "https://github.com/obophenotype/uberon/issues/271" ] + }, + "comments" : [ "The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB]" ], + "xrefs" : [ { + "val" : "AAO:0000327" + }, { + "val" : "BTO:0001768" + }, { + "val" : "CALOHA:TS-0690" + }, { + "val" : "EHDAA2:0001277" + }, { + "val" : "EHDAA:1241" + }, { + "val" : "EHDAA:6021" + }, { + "val" : "EMAPA:16191" + }, { + "val" : "EV:0100002" + }, { + "val" : "FMA:85521" + }, { + "val" : "GAID:1311" + }, { + "val" : "MAT:0000281" + }, { + "val" : "MESH:D009672" + }, { + "val" : "NCIT:C12463" + }, { + "val" : "SCTID:308820002" + }, { + "val" : "TAO:0000135" + }, { + "val" : "VHOG:0000199" + }, { + "val" : "VSAO:0000032" + }, { + "val" : "Wikipedia:Notochord" + }, { + "val" : "XAO:0000055" + }, { + "val" : "ZFA:0000135" + }, { + "val" : "http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002329", + "lbl" : "somite", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.", + "xrefs" : [ "DOI:10.1111/j.1439-0426.2012.01987.x", "Wikipedia:Somite" ] + }, + "comments" : [ "When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248]" ], + "xrefs" : [ { + "val" : "AAO:0010569" + }, { + "val" : "AEO:0001015" + }, { + "val" : "BTO:0001558" + }, { + "val" : "EHDAA2:0003436" + }, { + "val" : "EHDAA:366" + }, { + "val" : "EHDAA:699" + }, { + "val" : "EMAPA:31169" + }, { + "val" : "FMA:85522" + }, { + "val" : "GAID:1306" + }, { + "val" : "MAT:0000068" + }, { + "val" : "MESH:D019170" + }, { + "val" : "MIAA:0000068" + }, { + "val" : "NCIT:C34302" + }, { + "val" : "TAO:0000155" + }, { + "val" : "VHOG:0000191" + }, { + "val" : "Wikipedia:Somite" + }, { + "val" : "XAO:0000058" + }, { + "val" : "ZFA:0000155" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002330", + "lbl" : "exocrine system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia].", + "xrefs" : [ "Wikipedia:Exocrine_gland" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2057" + }, { + "val" : "EHDAA2:0002225" + }, { + "val" : "EMAPA:35329" + }, { + "val" : "FMA:85539" + }, { + "val" : "MA:0002411" + }, { + "val" : "NCIT:C12957" + }, { + "val" : "Wikipedia:Exocrine_gland" + }, { + "val" : "WikipediaCategory:Exocrine_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002333", + "lbl" : "pulmonary trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arterial trunk which is continuous with the heart and branches into the pulmonary arteries.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001576" + }, { + "val" : "EHDAA:9831" + }, { + "val" : "EMAPA:17015" + }, { + "val" : "FMA:8612" + }, { + "val" : "MA:0002033" + }, { + "val" : "NCIT:C116918" + }, { + "val" : "VHOG:0001134" + }, { + "val" : "galen:PulmonaryTrunk" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002338", + "lbl" : "lamina propria of bronchus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35194" + }, { + "val" : "FMA:86619" + }, { + "val" : "MA:0001836" + }, { + "val" : "NCIT:C49212" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002342", + "lbl" : "neural crest", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].", + "xrefs" : [ "MP:0009846" ] + }, + "comments" : [ "Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells." ], + "xrefs" : [ { + "val" : "AAO:0010578" + }, { + "val" : "BTO:0001764" + }, { + "val" : "CALOHA:TS-0676" + }, { + "val" : "EHDAA2:0004419" + }, { + "val" : "EMAPA:32737" + }, { + "val" : "FMA:86666" + }, { + "val" : "GAID:1310" + }, { + "val" : "MAT:0000066" + }, { + "val" : "MESH:D009432" + }, { + "val" : "MIAA:0000066" + }, { + "val" : "NCIT:C34222" + }, { + "val" : "SCTID:361462002" + }, { + "val" : "VHOG:0000057" + }, { + "val" : "Wikipedia:Neural_crest" + }, { + "val" : "XAO:0000048" + }, { + "val" : "ZFA:0000045" + }, { + "val" : "neuronames:1366" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002343", + "lbl" : "abdomen musculature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Set of all muscles in abdomen.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:71294" + }, { + "val" : "FMA:86917" + }, { + "val" : "TAO:0001327" + }, { + "val" : "ZFA:0001327" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002345", + "lbl" : "descending thoracic aorta", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.", + "xrefs" : [ "MP:0009868" ] + }, + "xrefs" : [ { + "val" : "EFO:0002527" + }, { + "val" : "EMAPA:18605" + }, { + "val" : "FMA:87217" + }, { + "val" : "MA:0002572" + }, { + "val" : "SCTID:181301002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002346", + "lbl" : "neurectoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Embryonic ectoderm that gives rise to nervous tissue.", + "xrefs" : [ "Wikipedia:Neuroectoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0011074" + }, { + "val" : "BILA:0000039" + }, { + "val" : "CALOHA:TS-1212" + }, { + "val" : "EHDAA2:0001248" + }, { + "val" : "EHDAA:1498" + }, { + "val" : "EHDAA:255" + }, { + "val" : "EMAPA:16073" + }, { + "val" : "EV:0100004" + }, { + "val" : "FMA:87657" + }, { + "val" : "MAT:0000176" + }, { + "val" : "MIAA:0000176" + }, { + "val" : "NCIT:C34228" + }, { + "val" : "TAO:0001120" + }, { + "val" : "VHOG:0000150" + }, { + "val" : "Wikipedia:Neuroectoderm" + }, { + "val" : "XAO:0000042" + }, { + "val" : "ZFA:0001120" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "lbl" : "thoracic vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thoracic vertebra endochondral element that is composed primarily of a bone tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18011" + }, { + "val" : "FMA:9139" + }, { + "val" : "GAID:244" + }, { + "val" : "MA:0000314" + }, { + "val" : "MESH:D013904" + }, { + "val" : "NCIT:C12798" + }, { + "val" : "SCTID:181821009" + }, { + "val" : "Wikipedia:Thoracic_vertebrae" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002348", + "lbl" : "epicardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "EDITOR_NOTE TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer." ], + "xrefs" : [ { + "val" : "AAO:0010409" + }, { + "val" : "EHDAA2:0002202" + }, { + "val" : "FMA:9461" + }, { + "val" : "NCIT:C13164" + }, { + "val" : "TAO:0005057" + }, { + "val" : "VHOG:0000119" + }, { + "val" : "Wikipedia:Epicardium" + }, { + "val" : "XAO:0000316" + }, { + "val" : "ZFA:0005057" + }, { + "val" : "galen:Epicardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002349", + "lbl" : "myocardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The middle layer of the heart, comprised mainly of striated cardiac muscle fibers.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0005329" ] + }, + "comments" : [ "EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium" ], + "xrefs" : [ { + "val" : "AAO:0010410" + }, { + "val" : "BSA:0000089" + }, { + "val" : "BTO:0000901" + }, { + "val" : "CALOHA:TS-0440" + }, { + "val" : "EFO:0000819" + }, { + "val" : "EHDAA2:0004150" + }, { + "val" : "EV:0100022" + }, { + "val" : "FMA:9462" + }, { + "val" : "GAID:173" + }, { + "val" : "MA:0000164" + }, { + "val" : "MAT:0000453" + }, { + "val" : "MESH:D009206" + }, { + "val" : "NCIT:C12371" + }, { + "val" : "RETIRED_EHDAA2:0001220" + }, { + "val" : "SCTID:362012001" + }, { + "val" : "TAO:0001319" + }, { + "val" : "VHOG:0000083" + }, { + "val" : "Wikipedia:Myocardium" + }, { + "val" : "XAO:0000065" + }, { + "val" : "ZFA:0001319" + }, { + "val" : "galen:Myocardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002350", + "lbl" : "conducting system of heart", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO].", + "xrefs" : [ "GO:0003161" ] + }, + "xrefs" : [ { + "val" : "EFO:0003909" + }, { + "val" : "EHDAA2:0004185" + }, { + "val" : "EMAPA:35428" + }, { + "val" : "EV:0100025" + }, { + "val" : "FMA:9476" + }, { + "val" : "MA:0000094" + }, { + "val" : "MESH:D006329" + }, { + "val" : "SCTID:281489000" + }, { + "val" : "TAO:0005063" + }, { + "val" : "VHOG:0001271" + }, { + "val" : "ZFA:0005063" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002351", + "lbl" : "sinoatrial node", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA].", + "xrefs" : [ "GO:0003163", "Wikipedia:Sinoatrial_node" ] + }, + "comments" : [ "WP:Heart states: \"The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.\". Note however that ZFA has SA node." ], + "xrefs" : [ { + "val" : "BTO:0004358" + }, { + "val" : "EHDAA2:0004184" + }, { + "val" : "EMAPA:35772" + }, { + "val" : "FMA:9477" + }, { + "val" : "GAID:561" + }, { + "val" : "MA:0000097" + }, { + "val" : "MESH:D012849" + }, { + "val" : "NCIT:C33555" + }, { + "val" : "SCTID:277687007" + }, { + "val" : "TAO:0005069" + }, { + "val" : "Wikipedia:Sinoatrial_node" + }, { + "val" : "ZFA:0005069" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002352", + "lbl" : "atrioventricular node", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Atrioventricular_node" ] + }, + "xrefs" : [ { + "val" : "BTO:0005689" + }, { + "val" : "EFO:0000276" + }, { + "val" : "EHDAA2:0004183" + }, { + "val" : "EMAPA:35153" + }, { + "val" : "FMA:9478" + }, { + "val" : "GAID:558" + }, { + "val" : "MA:0000095" + }, { + "val" : "MAT:0000498" + }, { + "val" : "MESH:D001283" + }, { + "val" : "NCIT:C32161" + }, { + "val" : "SCTID:277688002" + }, { + "val" : "TAO:0005070" + }, { + "val" : "VHOG:0001474" + }, { + "val" : "Wikipedia:Atrioventricular_node" + }, { + "val" : "ZFA:0005070" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002354", + "lbl" : "cardiac Purkinje fiber", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.", + "xrefs" : [ "GO:0003165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001735" + }, { + "val" : "EMAPA:35718" + }, { + "val" : "FMA:9492" + }, { + "val" : "GAID:560" + }, { + "val" : "MA:0000096" + }, { + "val" : "MESH:D011690" + }, { + "val" : "NCIT:C33430" + }, { + "val" : "Wikipedia:Purkinje_fiber" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002357", + "lbl" : "serous pericardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Serous membrane which is divided into parietal and visceral serous pericardium.", + "xrefs" : [ "Wikipedia:Serous_pericardium", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19030" + }, { + "val" : "FMA:9582" + }, { + "val" : "MA:0002739" + }, { + "val" : "SCTID:243954002" + }, { + "val" : "Wikipedia:Serous_pericardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002358", + "lbl" : "peritoneum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that lines the peritoneal cavity[VHOG,modified].", + "xrefs" : [ "VHOG:0001257" ] + }, + "xrefs" : [ { + "val" : "AAO:0010814" + }, { + "val" : "BTO:0001472" + }, { + "val" : "CALOHA:TS-2072" + }, { + "val" : "EV:0100087" + }, { + "val" : "FMA:9584" + }, { + "val" : "GAID:18" + }, { + "val" : "MA:0000449" + }, { + "val" : "MESH:D010537" + }, { + "val" : "NCIT:C12770" + }, { + "val" : "TAO:0005120" + }, { + "val" : "VHOG:0001257" + }, { + "val" : "Wikipedia:Peritoneum" + }, { + "val" : "XAO:0000139" + }, { + "val" : "ZFA:0005120" + }, { + "val" : "galen:Peritoneum" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002359", + "lbl" : "fibrous pericardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA].", + "xrefs" : [ "FMA:9586" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19029" + }, { + "val" : "FMA:9586" + }, { + "val" : "MA:0002738" + }, { + "val" : "SCTID:243953008" + }, { + "val" : "Wikipedia:Fibrous_pericardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002365", + "lbl" : "exocrine gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas.", + "xrefs" : [ "Wikipedia:Exocrine_gland" ] + }, + "xrefs" : [ { + "val" : "AEO:0000097" + }, { + "val" : "BTO:0000765" + }, { + "val" : "CALOHA:TS-2012" + }, { + "val" : "EHDAA2:0003097" + }, { + "val" : "EMAPA:35327" + }, { + "val" : "FMA:9596" + }, { + "val" : "GAID:34" + }, { + "val" : "MA:0002564" + }, { + "val" : "MESH:D005088" + }, { + "val" : "NCIT:C12712" + }, { + "val" : "SCTID:115976003" + }, { + "val" : "Wikipedia:Exocrine_gland" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002368", + "lbl" : "endocrine gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified].", + "xrefs" : [ "Wikipedia:Endocrine_gland" ] + }, + "xrefs" : [ { + "val" : "AEO:0000098" + }, { + "val" : "BTO:0001488" + }, { + "val" : "CALOHA:TS-1300" + }, { + "val" : "EHDAA2:0003098" + }, { + "val" : "EMAPA:35999" + }, { + "val" : "FMA:9602" + }, { + "val" : "GAID:335" + }, { + "val" : "MA:0002563" + }, { + "val" : "MESH:D004702" + }, { + "val" : "NCIT:C12704" + }, { + "val" : "SCTID:40818001" + }, { + "val" : "Wikipedia:Endocrine_gland" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002371", + "lbl" : "bone marrow", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The soft tissue that fills the cavities of bones.", + "xrefs" : [ "MGI:cwg", "MP:0002397" ] + }, + "xrefs" : [ { + "val" : "AAO:0011007" + }, { + "val" : "BTO:0000141" + }, { + "val" : "BTO:0000829" + }, { + "val" : "CALOHA:TS-0087" + }, { + "val" : "EFO:0000868" + }, { + "val" : "EMAPA:32760" + }, { + "val" : "EV:0100046" + }, { + "val" : "FMA:9608" + }, { + "val" : "GAID:1287" + }, { + "val" : "MA:0000134" + }, { + "val" : "MAT:0000084" + }, { + "val" : "MESH:D001853" + }, { + "val" : "MIAA:0000084" + }, { + "val" : "NCIT:C12431" + }, { + "val" : "SCTID:421320006" + }, { + "val" : "VHOG:0001218" + }, { + "val" : "Wikipedia:Bone_marrow" + }, { + "val" : "XAO:0000123" + }, { + "val" : "galen:BoneMarrow" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002376", + "lbl" : "cranial muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any skeletal muscle that is part of the head region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984)" ], + "xrefs" : [ { + "val" : "AAO:0000107" + }, { + "val" : "BTO:0000021" + }, { + "val" : "EFO:0003524" + }, { + "val" : "EHDAA2:0000322" + }, { + "val" : "EMAPA:18172" + }, { + "val" : "FMA:9616" + }, { + "val" : "MA:0000578" + }, { + "val" : "SCTID:244718003" + }, { + "val" : "ZFA:0001652" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002377", + "lbl" : "muscle of neck", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle that is part of the cervical (neck) region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:9617" + }, { + "val" : "GAID:149" + }, { + "val" : "MA:0000587" + }, { + "val" : "MESH:D009334" + }, { + "val" : "NCIT:C33163" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002378", + "lbl" : "muscle of abdomen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis.", + "xrefs" : [ "Wikipedia:Abdominal_muscle" ] + }, + "xrefs" : [ { + "val" : "BTO:0001261" + }, { + "val" : "EMAPA:35103" + }, { + "val" : "FMA:9620" + }, { + "val" : "GAID:89" + }, { + "val" : "MA:0000520" + }, { + "val" : "MESH:D000009" + }, { + "val" : "NCIT:C32040" + }, { + "val" : "SCTID:361352008" + }, { + "val" : "Wikipedia:Abdominal_muscle" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002384", + "lbl" : "connective tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000017", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/23" ] + }, + "xrefs" : [ { + "val" : "AAO:0000098" + }, { + "val" : "BTO:0000421" + }, { + "val" : "CALOHA:TS-2009" + }, { + "val" : "EFO:0000952" + }, { + "val" : "EMAPA:35251" + }, { + "val" : "FMA:9640" + }, { + "val" : "GAID:100" + }, { + "val" : "MA:0000011" + }, { + "val" : "MAT:0000301" + }, { + "val" : "MESH:D003238" + }, { + "val" : "MIAA:0000301" + }, { + "val" : "NCIT:C12374" + }, { + "val" : "SCTID:361919005" + }, { + "val" : "TAO:0001641" + }, { + "val" : "VSAO:0000017" + }, { + "val" : "XAO:0001017" + }, { + "val" : "ZFA:0001632" + }, { + "val" : "galen:ConnectiveTissue" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002385", + "lbl" : "muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].", + "xrefs" : [ "GO:0060537", "Wikipedia:Muscle_tissue", "https://sourceforge.net/tracker/index.php?func=detail&aid=2801266&group_id=36855&atid=440764" ] + }, + "comments" : [ "Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach." ], + "xrefs" : [ { + "val" : "AAO:0000306" + }, { + "val" : "AEO:0000122" + }, { + "val" : "CALOHA:TS-0642" + }, { + "val" : "EHDAA2:0003122" + }, { + "val" : "EMAPA:32715" + }, { + "val" : "FMA:9641" + }, { + "val" : "MA:0002437" + }, { + "val" : "MESH:D009132" + }, { + "val" : "NCIT:C12435" + }, { + "val" : "SCTID:91727004" + }, { + "val" : "Wikipedia:Muscle_tissue" + }, { + "val" : "galen:MuscleTissue" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002390", + "lbl" : "hematopoietic system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that is involved in the production of hematopoietic cells.", + "xrefs" : [ "Wikipedia:Haematopoiesis" ] + }, + "xrefs" : [ { + "val" : "AAO:0011002" + }, { + "val" : "BTO:0000570" + }, { + "val" : "CALOHA:TS-0449" + }, { + "val" : "EFO:0000798" + }, { + "val" : "EMAPA:35402" + }, { + "val" : "EV:0100045" + }, { + "val" : "FMA:9667" + }, { + "val" : "GAID:1008" + }, { + "val" : "MA:0002434" + }, { + "val" : "MAT:0000022" + }, { + "val" : "MESH:D006413" + }, { + "val" : "MIAA:0000022" + }, { + "val" : "NCIT:C12909" + }, { + "val" : "SCTID:362587009" + }, { + "val" : "TAO:0005023" + }, { + "val" : "VHOG:0001624" + }, { + "val" : "Wikipedia:Haematopoiesis" + }, { + "val" : "XAO:0000122" + }, { + "val" : "ZFA:0005023" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "lbl" : "bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine.", + "xrefs" : [ "Wikipedia:Bile_duct", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011019" + }, { + "val" : "BTO:0000122" + }, { + "val" : "CALOHA:TS-0075" + }, { + "val" : "EMAPA:35171" + }, { + "val" : "EV:0100091" + }, { + "val" : "FMA:9706" + }, { + "val" : "GAID:280" + }, { + "val" : "MA:0000354" + }, { + "val" : "MESH:D001652" + }, { + "val" : "NCIT:C12376" + }, { + "val" : "SCTID:276157007" + }, { + "val" : "TAO:0001100" + }, { + "val" : "VHOG:0000212" + }, { + "val" : "Wikipedia:Bile_duct" + }, { + "val" : "XAO:0000134" + }, { + "val" : "ZFA:0001100" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "lbl" : "vomer", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The triangular flat bone of the nasal septum.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0000098" ] + }, + "xrefs" : [ { + "val" : "AAO:0000633" + }, { + "val" : "FMA:9710" + }, { + "val" : "MA:0001496" + }, { + "val" : "NCIT:C33888" + }, { + "val" : "SCTID:272678009" + }, { + "val" : "TAO:0000308" + }, { + "val" : "Wikipedia:Vomer" + }, { + "val" : "ZFA:0000308" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002400", + "lbl" : "parietal pleura", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outer serous membrane of the pulmonary pleural.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Pulmonary_pleurae" ] + }, + "comments" : [ "the part of the pleura external to the visceral pleura. It lines the inner surface of the chest wall, covers the diaphragm, and is reflected over the structures occupying the middle of the thorax" ], + "xrefs" : [ { + "val" : "EMAPA:16776" + }, { + "val" : "FMA:9733" + }, { + "val" : "MA:0002488" + }, { + "val" : "NCIT:C33273" + }, { + "val" : "SCTID:361998003" + }, { + "val" : "VHOG:0001495" + }, { + "val" : "Wikipedia:Parietal_pleura" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002401", + "lbl" : "visceral pleura", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Pulmonary_pleurae" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002205" + }, { + "val" : "EMAPA:16777" + }, { + "val" : "FMA:9734" + }, { + "val" : "MA:0002489" + }, { + "val" : "NCIT:C33881" + }, { + "val" : "SCTID:361997008" + }, { + "val" : "VHOG:0001496" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002402", + "lbl" : "pleural cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The fluid-filled cavity that lies between the visceral and parietal pleurae.", + "xrefs" : [ "Wikipedia:Pleural_cavity", "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "BTO:0004422" + }, { + "val" : "EHDAA2:0001475" + }, { + "val" : "EMAPA:16773" + }, { + "val" : "EMAPA:16774" + }, { + "val" : "FMA:9740" + }, { + "val" : "GAID:95" + }, { + "val" : "MA:0000055" + }, { + "val" : "MESH:D035422" + }, { + "val" : "NCIT:C12840" + }, { + "val" : "SCTID:361999006" + }, { + "val" : "VHOG:0000581" + }, { + "val" : "Wikipedia:Pleural_cavity" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002405", + "lbl" : "immune system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies.", + "xrefs" : [ "Wikipedia:Immune_system" ] + }, + "xrefs" : [ { + "val" : "AAO:0011003" + }, { + "val" : "BILA:0000104" + }, { + "val" : "BTO:0005810" + }, { + "val" : "FMA:9825" + }, { + "val" : "GAID:328" + }, { + "val" : "MA:0002711" + }, { + "val" : "MESH:D007107" + }, { + "val" : "NCIT:C12735" + }, { + "val" : "SCTID:362590003" + }, { + "val" : "TAO:0001159" + }, { + "val" : "VHOG:0001247" + }, { + "val" : "Wikipedia:Immune_system" + }, { + "val" : "XAO:0003152" + }, { + "val" : "ZFA:0001159" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002406", + "lbl" : "pericardial sac", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A double-walled sac containing the heart and the roots of the great vessels.", + "xrefs" : [ "Wikipedia:Pericardium", "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "FMA:9868" + }, { + "val" : "RETIRED_EHDAA2:0001443" + }, { + "val" : "SCTID:361326002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002407", + "lbl" : "pericardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium.", + "xrefs" : [ "Wikipedia:Pericardium", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010817" + }, { + "val" : "BSA:0000090" + }, { + "val" : "BTO:0000717" + }, { + "val" : "CALOHA:TS-0761" + }, { + "val" : "EFO:0000820" + }, { + "val" : "EHDAA:5376" + }, { + "val" : "EV:0100023" + }, { + "val" : "FMA:9869" + }, { + "val" : "GAID:569" + }, { + "val" : "MA:0000099" + }, { + "val" : "MAT:0000454" + }, { + "val" : "MESH:D010496" + }, { + "val" : "NCIT:C13005" + }, { + "val" : "RETIRED_EHDAA2:0001443" + }, { + "val" : "SCTID:181295003" + }, { + "val" : "VHOG:0001280" + }, { + "val" : "Wikipedia:Pericardium" + }, { + "val" : "XAO:0004182" + }, { + "val" : "ZFA:0000054" + }, { + "val" : "galen:Pericardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002408", + "lbl" : "parietal serous pericardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA:3422" + }, { + "val" : "EHDAA:5378" + }, { + "val" : "EMAPA:19031" + }, { + "val" : "FMA:9870" + }, { + "val" : "MA:0000483" + }, { + "val" : "NCIT:C94500" + }, { + "val" : "SCTID:243956000" + }, { + "val" : "VHOG:0000537" + }, { + "val" : "Wikipedia:Parietal_pericardium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002409", + "lbl" : "pericardial fluid", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Transudate contained in the pericardial cavity.[FMA].", + "xrefs" : [ "FMA:9887", "Wikipedia:Pericardial_fluid" ] + }, + "xrefs" : [ { + "val" : "BTO:0001016" + }, { + "val" : "FMA:9887" + }, { + "val" : "MA:0002530" + }, { + "val" : "Wikipedia:Pericardial_fluid" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002410", + "lbl" : "autonomic nervous system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO].", + "xrefs" : [ "GO:0048483" ] + }, + "xrefs" : [ { + "val" : "AAO:0000033" + }, { + "val" : "BIRNLEX:1123" + }, { + "val" : "BTO:0002507" + }, { + "val" : "CALOHA:TS-2001" + }, { + "val" : "EHDA:10095" + }, { + "val" : "EHDAA2:0000158" + }, { + "val" : "EHDAA:3767" + }, { + "val" : "EMAPA:16984" + }, { + "val" : "FMA:65553" + }, { + "val" : "GAID:706" + }, { + "val" : "MA:0000219" + }, { + "val" : "MESH:D001341" + }, { + "val" : "NCIT:C12673" + }, { + "val" : "SCTID:362481007" + }, { + "val" : "TAO:0001574" + }, { + "val" : "VHOG:0000396" + }, { + "val" : "Wikipedia:Autonomic_nervous_system" + }, { + "val" : "ZFA:0001574" + }, { + "val" : "neuronames:2054" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "lbl" : "vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000691" + }, { + "val" : "CALOHA:TS-2352" + }, { + "val" : "EFO:0001371" + }, { + "val" : "EMAPA:32740" + }, { + "val" : "FMA:9914" + }, { + "val" : "MA:0000309" + }, { + "val" : "NCIT:C12933" + }, { + "val" : "SCTID:181817002" + }, { + "val" : "TAO:0001189" + }, { + "val" : "Wikipedia:Vertebra" + }, { + "val" : "XAO:0004019" + }, { + "val" : "ZFA:0001189" + }, { + "val" : "galen:Vertebra" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "lbl" : "cervical vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vertebra that is located in the cervical region of the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17674" + }, { + "val" : "FMA:9915" + }, { + "val" : "GAID:235" + }, { + "val" : "MA:0000311" + }, { + "val" : "MESH:D002574" + }, { + "val" : "NCIT:C12693" + }, { + "val" : "SCTID:181820005" + }, { + "val" : "Wikipedia:Cervical_vertebrae" + }, { + "val" : "XAO:0003076" + }, { + "val" : "galen:CervicalVertebra" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002415", + "lbl" : "tail", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail.", + "xrefs" : [ "AEO:0000109", "Wikipedia:Tail" ] + }, + "xrefs" : [ { + "val" : "AEO:0000109" + }, { + "val" : "BILA:0000117" + }, { + "val" : "BTO:0001348" + }, { + "val" : "EFO:0000963" + }, { + "val" : "EHDAA:9198" + }, { + "val" : "GAID:1245" + }, { + "val" : "MAT:0000094" + }, { + "val" : "MESH:D013623" + }, { + "val" : "MIAA:0000094" + }, { + "val" : "WBbt:0005741" + }, { + "val" : "Wikipedia:Tail" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002416", + "lbl" : "integumental system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle.", + "xrefs" : [ "CARO:0002001", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/29" ] + }, + "xrefs" : [ { + "val" : "AEO:0000154" + }, { + "val" : "BILA:0000118" + }, { + "val" : "CALOHA:TS-1299" + }, { + "val" : "CARO:0002001" + }, { + "val" : "EFO:0000807" + }, { + "val" : "EHDAA2:0000836" + }, { + "val" : "EHDAA2_RETIRED:0003154" + }, { + "val" : "EHDAA:6520" + }, { + "val" : "EMAPA:17524" + }, { + "val" : "EV:0100151" + }, { + "val" : "FMA:72979" + }, { + "val" : "HAO:0000421" + }, { + "val" : "MA:0000014" + }, { + "val" : "MAT:0000033" + }, { + "val" : "MESH:D034582" + }, { + "val" : "MIAA:0000033" + }, { + "val" : "NCIT:C12907" + }, { + "val" : "SCTID:361692004" + }, { + "val" : "TADS:0000108" + }, { + "val" : "VHOG:0000403" + }, { + "val" : "Wikipedia:Integumentary_system" + }, { + "val" : "XAO:0000176" + }, { + "val" : "galen:Surface" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002417", + "lbl" : "abdominal segment of trunk", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The abdominal segment of the torso.", + "xrefs" : [ "Wikipedia:Lumbar" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35104" + }, { + "val" : "FMA:259211" + }, { + "val" : "MA:0000021" + }, { + "val" : "SCTID:362875007" + }, { + "val" : "Wikipedia:Lumbar" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0002418", + "lbl" : "cartilage tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000040", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/37", "https://sourceforge.net/p/obo/vertebrate-skeletal-anatomy-vsao-term-requests/5" ] + }, + "comments" : [ "Previous: \"A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten].\" See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W]" ], + "xrefs" : [ { + "val" : "AAO:0000060" + }, { + "val" : "AEO:0000087" + }, { + "val" : "BTO:0000206" + }, { + "val" : "EFO:0000949" + }, { + "val" : "EHDAA2:0003087" + }, { + "val" : "EMAPA:32730" + }, { + "val" : "EV:0100141" + }, { + "val" : "FMA:37377" + }, { + "val" : "GAID:99" + }, { + "val" : "MA:0000104" + }, { + "val" : "MAT:0000189" + }, { + "val" : "MESH:D002356" + }, { + "val" : "MIAA:0000189" + }, { + "val" : "NCIT:C12373" + }, { + "val" : "NCIT:C32268" + }, { + "val" : "SCTID:309312004" + }, { + "val" : "TAO:0001501" + }, { + "val" : "VHOG:0001207" + }, { + "val" : "VSAO:0000040" + }, { + "val" : "Wikipedia:Cartilage" + }, { + "val" : "XAO:0000170" + }, { + "val" : "ZFA:0005622" + }, { + "val" : "galen:Cartilage" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001586", - "lbl" : "internal jugular vein", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002419", + "lbl" : "skin gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland that is part of a skin of body [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35774" + }, { + "val" : "FMA:71878" + }, { + "val" : "MA:0000146" + }, { + "val" : "SCTID:110485007" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001592", - "lbl" : "bronchial vein", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "lbl" : "hepatobiliary system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the digestive system that contains the liver and the biliary system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011056" + }, { + "val" : "CALOHA:TS-1308" + }, { + "val" : "EFO:0000800" + }, { + "val" : "EHDAA2:0000998" + }, { + "val" : "EHDAA:2189" + }, { + "val" : "EMAPA:16840" + }, { + "val" : "EV:0100088" + }, { + "val" : "MA:0000324" + }, { + "val" : "MAT:0000024" + }, { + "val" : "MIAA:0000024" + }, { + "val" : "NCIT:C43612" + }, { + "val" : "TAO:0000036" + }, { + "val" : "VHOG:0000294" + }, { + "val" : "Wikipedia:Hepatobiliary_system" + }, { + "val" : "XAO:0000132" + }, { + "val" : "ZFA:0000036" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001605", - "lbl" : "ciliary muscle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002424", + "lbl" : "oral epithelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010357" + }, { + "val" : "BTO:0001775" + }, { + "val" : "CALOHA:TS-0715" + }, { + "val" : "EHDAA2:0001325" + }, { + "val" : "EHDAA:2187" + }, { + "val" : "EMAPA:16839" + }, { + "val" : "EMAPA:26942" + }, { + "val" : "FMA:265152" + }, { + "val" : "MA:0000344" + }, { + "val" : "NCIT:C49595" + }, { + "val" : "TAO:0000816" + }, { + "val" : "VHOG:0000187" + }, { + "val" : "XAO:0003201" + }, { + "val" : "ZFA:0000816" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001606", - "lbl" : "muscle of iris", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001612", - "lbl" : "facial artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002425", + "lbl" : "visceral serous pericardium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA].", + "xrefs" : [ "Wikipedia:Visceral_pericardium" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19032" + }, { + "val" : "FMA:84882" + }, { + "val" : "MA:0000484" + }, { + "val" : "SCTID:243955001" + }, { + "val" : "VHOG:0000538" + }, { + "val" : "Wikipedia:Visceral_pericardium" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001630", - "lbl" : "muscle organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001637", - "lbl" : "artery", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001638", - "lbl" : "vein", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001645", - "lbl" : "trigeminal nerve", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002443", + "lbl" : "choroidal blood vessel", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A blood vessel that is part of a choroid [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "cannot find singular in FMA, using Set class" ], + "xrefs" : [ { + "val" : "EMAPA:17828" + }, { + "val" : "FMA:76550" + }, { + "val" : "MA:0001237" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001651", - "lbl" : "right pulmonary artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002457", + "lbl" : "intersomitic artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries.", + "xrefs" : [ "MP:0010662" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000882" + }, { + "val" : "EHDAA:4340" + }, { + "val" : "EMAPA:17616" + }, { + "val" : "MA:0001985" + }, { + "val" : "SCTID:360401001" + }, { + "val" : "TAO:0001061" + }, { + "val" : "VHOG:0000225" + }, { + "val" : "XAO:0004165" + }, { + "val" : "ZFA:0001061" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001652", - "lbl" : "left pulmonary artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002458", + "lbl" : "spinal artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Arteries that supply the spinal cord.", + "xrefs" : [ "Wikipedia:Spinal_artery", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001890" + }, { + "val" : "EHDAA:4355" + }, { + "val" : "EMAPA:18241" + }, { + "val" : "MA:0002043" + }, { + "val" : "NCIT:C33587" + }, { + "val" : "SCTID:244228006" + }, { + "val" : "TAO:0000682" + }, { + "val" : "Wikipedia:Spinal_artery" + }, { + "val" : "ZFA:0000682" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001653", - "lbl" : "facial vein", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002466", + "lbl" : "intestine secretion", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine.", + "xrefs" : [ "Wikipedia:Succus_entericus" ] + }, + "xrefs" : [ { + "val" : "BTO:0000644" + }, { + "val" : "FMA:62974" + }, { + "val" : "GAID:1162" + }, { + "val" : "MA:0002515" + }, { + "val" : "MESH:D007419" + }, { + "val" : "NCIT:C32875" + }, { + "val" : "Wikipedia:Succus_entericus" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001675", - "lbl" : "trigeminal ganglion", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001676", - "lbl" : "occipital bone", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002469", + "lbl" : "esophagus mucosa", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mucosa that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0002859" + }, { + "val" : "EMAPA:26981" + }, { + "val" : "FMA:62996" + }, { + "val" : "MA:0002680" + }, { + "val" : "NCIT:C32538" + }, { + "val" : "SCTID:362127004" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001703", - "lbl" : "neurocranium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002481", + "lbl" : "bone tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000047", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2011" + }, { + "val" : "EMAPA:35179" + }, { + "val" : "FMA:224804" + }, { + "val" : "MA:0002780" + }, { + "val" : "MESH:D001842" + }, { + "val" : "NCIT:C13076" + }, { + "val" : "VSAO:0000047" + }, { + "val" : "Wikipedia:Bone_tissue" + }, { + "val" : "XAO:0004040" + }, { + "val" : "ZFA:0005621" + }, { + "val" : "galen:BoneTissue" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001708", - "lbl" : "jaw skeleton", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001710", - "lbl" : "lower jaw region", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001714", - "lbl" : "cranial ganglion", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002506", + "lbl" : "iris epithelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelium that is part of a iris [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35447" + }, { + "val" : "FMA:58517" + }, { + "val" : "MA:0002826" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001731", - "lbl" : "cavity of pharynx", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001766", - "lbl" : "anterior chamber of eyeball", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001768", - "lbl" : "uvea", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001769", - "lbl" : "iris", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002511", + "lbl" : "trabecula carnea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The supporting bundles of muscular fibers lining the walls of the ventricles of the heart.", + "xrefs" : [ "MGI:monikat", "MP:0004067" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18626" + }, { + "val" : "FMA:7269" + }, { + "val" : "MA:0002831" + }, { + "val" : "SCTID:118755002" + }, { + "val" : "Wikipedia:Trabeculae_carneae" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001772", - "lbl" : "corneal epithelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002513", + "lbl" : "endochondral bone", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Replacement bone that forms within cartilage.", + "xrefs" : [ "GO:0001958", "GO_REF:0000034", "VSAO:0000145", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/54" ] + }, + "xrefs" : [ { + "val" : "AAO:0010776" + }, { + "val" : "AEO:0000083" + }, { + "val" : "BTO:0002157" + }, { + "val" : "EHDAA2:0003083" + }, { + "val" : "FMA:24321" + }, { + "val" : "TAO:0001591" + }, { + "val" : "VSAO:0000145" + }, { + "val" : "XAO:0004018" + }, { + "val" : "ZFA:0001591" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001773", - "lbl" : "sclera", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002514", + "lbl" : "intramembranous bone", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].", + "xrefs" : [ "GO:0001957", "Wikipedia:Intramembranous_ossification", "https://github.com/obophenotype/uberon/issues/267" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36615" + }, { + "val" : "TAO:0001644" + }, { + "val" : "Wikipedia:Intramembranous_ossification" + }, { + "val" : "ZFA:0001635" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001774", - "lbl" : "skeletal muscle of trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001775", - "lbl" : "ciliary body", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002517", + "lbl" : "basicranium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof.", + "xrefs" : [ "Wikipedia:Base_of_skull" ] + }, + "comments" : [ "The skull base is formed from a series of cartilages either side of, and rostral to, the notochord, whose tip lies just caudal to the pituitary gland. It is closely associated with the sensory capsules, which partially or completely sur- round the olfactory epithelium, the eye, and the inner ear[PMID:11523816]" ], + "xrefs" : [ { + "val" : "FMA:52801" + }, { + "val" : "MA:0002840" + }, { + "val" : "MESH:D019291" + }, { + "val" : "MFMO:0000044" + }, { + "val" : "NCIT:C12493" + }, { + "val" : "SCTID:181890004" + }, { + "val" : "Wikipedia:Base_of_skull" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001776", - "lbl" : "optic choroid", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002521", + "lbl" : "elastic tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Connective tissue composed of elastic fibers.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:20113" + }, { + "val" : "GAID:926" + }, { + "val" : "MA:0002853" + }, { + "val" : "MESH:D004547" + }, { + "val" : "NCIT:C32495" + }, { + "val" : "SCTID:27197004" + }, { + "val" : "Wikipedia:Elastic_fiber" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001777", - "lbl" : "substantia propria of cornea", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001778", - "lbl" : "ciliary epithelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002522", + "lbl" : "tunica media", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The middle layer of an artery or vein. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Tunica_media" ] + }, + "comments" : [ "May be composed of smooth muscle and elastic tissue" ], + "xrefs" : [ { + "val" : "BTO:0002011" + }, { + "val" : "EMAPA:36298" + }, { + "val" : "FMA:55590" + }, { + "val" : "GAID:170" + }, { + "val" : "MA:0002855" + }, { + "val" : "MESH:D017540" + }, { + "val" : "NCIT:C33821" + }, { + "val" : "SCTID:61695000" + }, { + "val" : "Wikipedia:Tunica_media" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001779", - "lbl" : "iris stroma", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001780", - "lbl" : "spinal nerve", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002523", + "lbl" : "tunica intima", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong].", + "xrefs" : [ "ISBN:0073040584", "NCIT:C33820", "Wikipedia:Tunica_intima" ] + }, + "xrefs" : [ { + "val" : "BTO:0002012" + }, { + "val" : "EMAPA:36297" + }, { + "val" : "FMA:55589" + }, { + "val" : "GAID:523" + }, { + "val" : "MA:0002861" + }, { + "val" : "MESH:D017539" + }, { + "val" : "NCIT:C33820" + }, { + "val" : "SCTID:8361002" + }, { + "val" : "SCTID:87483006" + }, { + "val" : "Wikipedia:Tunica_intima" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001781", - "lbl" : "layer of retina", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001785", - "lbl" : "cranial nerve", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002530", + "lbl" : "gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An organ that functions as a secretory or excretory organ.", + "xrefs" : [ "MGI:csmith", "MP:0002163" ] + }, + "xrefs" : [ { + "val" : "AAO:0000212" + }, { + "val" : "AEO:0000096" + }, { + "val" : "BTO:0000522" + }, { + "val" : "EFO:0000797" + }, { + "val" : "EHDAA2:0003096" + }, { + "val" : "EHDAA:2161" + }, { + "val" : "EMAPA:18425" + }, { + "val" : "FMA:7146" + }, { + "val" : "FMA:86294" + }, { + "val" : "HAO:0000375" + }, { + "val" : "MA:0003038" + }, { + "val" : "MAT:0000021" + }, { + "val" : "MIAA:0000021" + }, { + "val" : "NCIT:C13319" + }, { + "val" : "SCTID:134358001" + }, { + "val" : "Wikipedia:Gland" + }, { + "val" : "WikipediaCategory:Glands" + }, { + "val" : "galen:Gland" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001796", - "lbl" : "aqueous humor of eyeball", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001800", - "lbl" : "sensory ganglion", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002532", + "lbl" : "epiblast (generic)", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA].", + "xrefs" : [ "Wikipedia:Epiblast", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "BTO:0004593" + }, { + "val" : "FMA:296704" + }, { + "val" : "MAT:0000067" + }, { + "val" : "MIAA:0000067" + }, { + "val" : "VHOG:0000243" + }, { + "val" : "Wikipedia:Epiblast" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001801", - "lbl" : "anterior segment of eyeball", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001802", - "lbl" : "posterior segment of eyeball", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001803", - "lbl" : "epithelium of lens", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002533", + "lbl" : "post-anal tail bud", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node.", + "xrefs" : [ "BTO:0001445" ] + }, + "xrefs" : [ { + "val" : "AAO:0011104" + }, { + "val" : "BTO:0001445" + }, { + "val" : "EFO:0002748" + }, { + "val" : "EHDAA2:0001976" + }, { + "val" : "EHDAA:1595" + }, { + "val" : "EMAPA:16580" + }, { + "val" : "MAT:0000070" + }, { + "val" : "MIAA:0000070" + }, { + "val" : "TAO:0000077" + }, { + "val" : "VHOG:0000201" + }, { + "val" : "XAO:0000107" + }, { + "val" : "ZFA:0000077" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001804", - "lbl" : "capsule of lens", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001805", - "lbl" : "autonomic ganglion", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002536", + "lbl" : "arthropod sensillum", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt].", + "xrefs" : [ "FBbt:00007152", "Wikipedia:Sensillum" ] + }, + "xrefs" : [ { + "val" : "BTO:0001237" + }, { + "val" : "EFO:0000939" + }, { + "val" : "HAO:0000933" + }, { + "val" : "MAT:0000163" + }, { + "val" : "MIAA:0000163" + }, { + "val" : "TGMA:0000540" + }, { + "val" : "Wikipedia:Sensillum" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001806", - "lbl" : "sympathetic ganglion", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001833", - "lbl" : "lip", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001835", - "lbl" : "lower lip", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001884", - "lbl" : "phrenic nerve", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002539", + "lbl" : "pharyngeal arch", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches.", + "xrefs" : [ "PMID:16313389", "ZFA:yb", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010359" + }, { + "val" : "BTO:0001785" + }, { + "val" : "EFO:0000959" + }, { + "val" : "EHDAA:571" + }, { + "val" : "EMAPA:16117" + }, { + "val" : "FMA:293015" + }, { + "val" : "GAID:1292" + }, { + "val" : "MAT:0000242" + }, { + "val" : "MESH:D001934" + }, { + "val" : "MIAA:0000242" + }, { + "val" : "NCIT:C34249" + }, { + "val" : "SCTID:308766004" + }, { + "val" : "TAO:0001306" + }, { + "val" : "VHOG:0000155" + }, { + "val" : "Wikipedia:Pharyngeal_arch" + }, { + "val" : "XAO:0000096" + }, { + "val" : "ZFA:0001306" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001891", - "lbl" : "midbrain", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002546", + "lbl" : "cranial placode", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic.", + "xrefs" : [ "http://www.ncbi.nlm.nih.gov/books/NBK53175/", "https://github.com/obophenotype/uberon/issues/135", "https://github.com/seger/aao/issues/4", "https://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/p/obo/xenopus-anatomy-xao-term-requests/11/" ] + }, + "xrefs" : [ { + "val" : "AAO:0010466" + }, { + "val" : "EFO:0001650" + }, { + "val" : "MAT:0000369" + }, { + "val" : "MIAA:0000369" + }, { + "val" : "XAO:0000305" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001892", - "lbl" : "rhombomere", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001895", - "lbl" : "metencephalon", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001896", - "lbl" : "medulla oblongata", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002553", + "lbl" : "anatomical cavity", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina.", + "xrefs" : [ "FMA:67552" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1011" + }, { + "val" : "FMA:67552" + }, { + "val" : "MA:0002447" + }, { + "val" : "NCIT:C34007" + }, { + "val" : "galen:Cavity" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001901", - "lbl" : "epithelium of trachea", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002558", + "lbl" : "organ cavity", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "BIRNLEX:1019" + }, { + "val" : "FMA:12237" + }, { + "val" : "SCTID:362606005" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001915", - "lbl" : "endothelium of capillary", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001916", - "lbl" : "endothelium of arteriole", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001917", - "lbl" : "endothelium of artery", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001918", - "lbl" : "endothelium of venule", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001919", - "lbl" : "endothelium of vein", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001943", - "lbl" : "midbrain tegmentum", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002561", + "lbl" : "lumen of central nervous system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1029" + }, { + "val" : "FMA:75007" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001948", - "lbl" : "regional part of spinal cord", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001955", - "lbl" : "epithelium of respiratory bronchiole", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002616", + "lbl" : "regional part of brain", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia.", + "xrefs" : [ "BIRNLEX:1167" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1167" + }, { + "val" : "FMA:55676" + }, { + "val" : "NCIT:C13031" + }, { + "val" : "SCTID:384763002" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001956", - "lbl" : "cartilage of bronchus", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002726", + "lbl" : "cervical spinal cord", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A spinal cord segment that adjacent_to a cervical region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1499" + }, { + "val" : "FMA:71166" + }, { + "val" : "MA:0003081" + }, { + "val" : "NCIT:C12892" + }, { + "val" : "SCTID:180960003" + }, { + "val" : "neuronames:1654" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001957", - "lbl" : "submucosa of bronchus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001958", - "lbl" : "terminal bronchiole epithelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0002925", + "lbl" : "trigeminal nucleus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A nucleus of brain that is part of a trigeminal nuclear complex.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BM:V" + }, { + "val" : "BTO:0001074" + }, { + "val" : "CALOHA:TS-2077" + }, { + "val" : "EMAPA:35883" + }, { + "val" : "EV:0100271" + }, { + "val" : "FMA:71247" + }, { + "val" : "GAID:604" + }, { + "val" : "MA:0001028" + }, { + "val" : "MESH:D014278" + }, { + "val" : "NCIT:C12807" + }, { + "val" : "SCTID:280164007" + }, { + "val" : "VHOG:0001353" + }, { + "val" : "http://uri.neuinfo.org/nif/nifstd/nifext_11" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001969", - "lbl" : "blood plasma", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003023", + "lbl" : "pontine tegmentum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133).", + "xrefs" : [ "BIRNLEX:923" ] + }, + "xrefs" : [ { + "val" : "BAMS:PTg" + }, { + "val" : "BIRNLEX:923" + }, { + "val" : "DHBA:12416" + }, { + "val" : "FMA:71108" + }, { + "val" : "HBA:9135" + }, { + "val" : "SCTID:362401009" + }, { + "val" : "Wikipedia:Pontine_tegmentum" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001971", - "lbl" : "gastric juice", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003037", + "lbl" : "septum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A wall, dividing a cavity or structure into smaller ones[WP].", + "xrefs" : [ "Wikipedia:Septum" ] + }, + "comments" : [ "general anatomical term in FMA" ], + "xrefs" : [ { + "val" : "AAO:0011127" + }, { + "val" : "FMA:86461" + }, { + "val" : "Wikipedia:Septum" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001972", - "lbl" : "submucosa of esophagus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003038", + "lbl" : "thoracic spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Thoracic_spinal_cord" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:966" + }, { + "val" : "FMA:71167" + }, { + "val" : "MA:0003082" + }, { + "val" : "NCIT:C12894" + }, { + "val" : "SCTID:278750009" + }, { + "val" : "Wikipedia:Thoracic_spinal_cord" + }, { + "val" : "neuronames:1718" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001974", - "lbl" : "lamina propria of esophagus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003052", + "lbl" : "midbrain-hindbrain boundary", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate.", + "xrefs" : [ "GO:0021555" ] + }, + "xrefs" : [ { + "val" : "AAO:0011064" + }, { + "val" : "DMBA:16810" + }, { + "val" : "EHDAA2:0004395" + }, { + "val" : "EHDAA:5789" + }, { + "val" : "EMAPA:32857" + }, { + "val" : "NCIT:C93172" + }, { + "val" : "TAO:0000042" + }, { + "val" : "VHOG:0000649" + }, { + "val" : "XAO:0000016" + }, { + "val" : "ZFA:0000042" + }, { + "val" : "neuronames:2076" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001975", - "lbl" : "serosa of esophagus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003055", + "lbl" : "periderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm.", + "xrefs" : [ "ISBN:9780878932504", "PMID:25133425", "PMID:35582825" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001846" + }, { + "val" : "EHDAA:6538" + }, { + "val" : "FMA:295662" + }, { + "val" : "NCIT:C34247" + }, { + "val" : "TAO:0001185" + }, { + "val" : "VHOG:0001680" + }, { + "val" : "XAO:0000029" + }, { + "val" : "ZFA:0001185" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001976", - "lbl" : "epithelium of esophagus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003056", + "lbl" : "pre-chordal neural plate", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of neural plate anterior to the mid-hindbrain junction.", + "xrefs" : [ "XB:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011084" + }, { + "val" : "TAO:0007016" + }, { + "val" : "VHOG:0001200" + }, { + "val" : "XAO:0000045" + }, { + "val" : "ZFA:0007016" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001979", - "lbl" : "venule", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003057", + "lbl" : "chordal neural plate", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The portion of neural plate posterior to the mid-hindbrain junction.", + "xrefs" : [ "XB:curator" ] + }, + "xrefs" : [ { + "val" : "TAO:0007017" + }, { + "val" : "VHOG:0001201" + }, { + "val" : "XAO:0000046" + }, { + "val" : "ZFA:0007017" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001980", - "lbl" : "arteriole", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003059", + "lbl" : "presomitic mesoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011086" + }, { + "val" : "EFO:0001982" + }, { + "val" : "EMAPA:16189" + }, { + "val" : "EMAPA:16752" + }, { + "val" : "TAO:0000279" + }, { + "val" : "VHOG:0000559" + }, { + "val" : "XAO:0000057" + }, { + "val" : "ZFA:0000279" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001981", - "lbl" : "blood vessel", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003061", + "lbl" : "blood island", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted].", + "xrefs" : [ "Wikipedia:Blood_island_of_umbilical_vesicle" ] + }, + "xrefs" : [ { + "val" : "AAO:0011006" + }, { + "val" : "EFO:0003489" + }, { + "val" : "EHDAA:207" + }, { + "val" : "NCIT:C34113" + }, { + "val" : "TAO:0000094" + }, { + "val" : "TE:E5.11.2.0.0.0.4" + }, { + "val" : "VHOG:0000085" + }, { + "val" : "Wikipedia:Blood_island_of_umbilical_vesicle" + }, { + "val" : "XAO:0000067" + }, { + "val" : "ZFA:0000094" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001982", - "lbl" : "capillary", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003063", + "lbl" : "prechordal plate", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue.", + "xrefs" : [ "ISBN:0838580343", "MP:0004387" ] + }, + "xrefs" : [ { + "val" : "AAO:0011085" + }, { + "val" : "EHDAA2:0001493" + }, { + "val" : "EHDAA:181" + }, { + "val" : "FMA:295532" + }, { + "val" : "TAO:0000060" + }, { + "val" : "VHOG:0000086" + }, { + "val" : "Wikipedia:Prechordal_plate" + }, { + "val" : "XAO:0000079" + }, { + "val" : "ZFA:0000060" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001985", - "lbl" : "corneal endothelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003064", + "lbl" : "intermediate mesoderm", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.", + "xrefs" : [ "GOC:curators", "Wikipedia:Intermediate_mesoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0010575" + }, { + "val" : "EMAPA:16056" + }, { + "val" : "EMAPA:16178" + }, { + "val" : "FMA:293147" + }, { + "val" : "NCIT:C34193" + }, { + "val" : "SCTID:361476001" + }, { + "val" : "TAO:0001206" + }, { + "val" : "VHOG:0000087" + }, { + "val" : "Wikipedia:Intermediate_mesoderm" + }, { + "val" : "XAO:0000085" + }, { + "val" : "ZFA:0001206" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001986", - "lbl" : "endothelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003067", + "lbl" : "dorsolateral placode", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Lateral neurogenic placodes positioned dorsal of the epibranchial placodes.", + "xrefs" : [ "ZFIN:curator" ] + }, + "comments" : [ "The only remaining dorsolateral placode in land vertebrates is the otic/octaval placode" ], + "xrefs" : [ { + "val" : "TAO:0001310" + }, { + "val" : "VHOG:0000103" + }, { + "val" : "XAO:0000187" + }, { + "val" : "ZFA:0001310" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0001994", - "lbl" : "hyaline cartilage tissue", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003068", + "lbl" : "axial mesoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.", + "xrefs" : [ "GO:0048318", "Wikipedia:Chordamesoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0011017" + }, { + "val" : "EFO:0003647" + }, { + "val" : "TAO:0001204" + }, { + "val" : "VHOG:0000107" + }, { + "val" : "Wikipedia:Chordamesoderm" + }, { + "val" : "XAO:0000205" + }, { + "val" : "ZFA:0001204" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002012", - "lbl" : "pulmonary artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003070", + "lbl" : "trigeminal placode complex", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion.", + "xrefs" : [ "PMID:22512454", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/693" ] + }, + "xrefs" : [ { + "val" : "EFO:0003433" + }, { + "val" : "EHDAA2:0004209" + }, { + "val" : "TAO:0000162" + }, { + "val" : "VHOG:0000109" + }, { + "val" : "XAO:0000225" + }, { + "val" : "ZFA:0000162" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002016", - "lbl" : "pulmonary vein", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003071", + "lbl" : "eye primordium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles.", + "xrefs" : [ "GO:0046619", "ZFA:0000570" ] + }, + "xrefs" : [ { + "val" : "AAO:0011038" + }, { + "val" : "EFO:0003541" + }, { + "val" : "EHDAA2:0004431" + }, { + "val" : "TAO:0000570" + }, { + "val" : "XAO:0000227" + }, { + "val" : "XAO:0004090" + }, { + "val" : "ZFA:0000570" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002020", - "lbl" : "gray matter", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003072", + "lbl" : "optic cup", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP].", + "xrefs" : [ "MP:0004269", "Wikipedia:Optic_cup_(embryology)", "ZFA:0001202" ] + }, + "xrefs" : [ { + "val" : "BTO:0005351" + }, { + "val" : "EHDAA2:0001303" + }, { + "val" : "EHDAA:2912" + }, { + "val" : "EMAPA:16674" + }, { + "val" : "NCIT:C34233" + }, { + "val" : "SCTID:308789007" + }, { + "val" : "TAO:0001202" + }, { + "val" : "VHOG:0000167" + }, { + "val" : "ZFA:0001202" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002028", - "lbl" : "hindbrain", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003073", + "lbl" : "lens placode", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP].", + "xrefs" : [ "Wikipedia:Lens_placode", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011055" + }, { + "val" : "EFO:0003494" + }, { + "val" : "EHDAA2:0000982" + }, { + "val" : "EHDAA:2908" + }, { + "val" : "EMAPA:16672" + }, { + "val" : "FMA:296767" + }, { + "val" : "NCIT:C34202" + }, { + "val" : "TAO:0000122" + }, { + "val" : "VHOG:0000166" + }, { + "val" : "Wikipedia:Lens_placode" + }, { + "val" : "XAO:0000240" + }, { + "val" : "ZFA:0000122" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002031", - "lbl" : "epithelium of bronchus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003075", + "lbl" : "neural plate", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].", + "xrefs" : [ "ISBN:0815318960", "OMD:neural+plate", "Wikipedia:Neural_plate", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011072" + }, { + "val" : "BTO:0001765" + }, { + "val" : "DHBA:10153" + }, { + "val" : "DMBA:15565" + }, { + "val" : "EHDAA:346" + }, { + "val" : "EHDAA:902" + }, { + "val" : "EMAPA:35593" + }, { + "val" : "FMA:293879" + }, { + "val" : "NCIT:C34225" + }, { + "val" : "RETIRED_EHDAA2:0001252" + }, { + "val" : "TAO:0000132" + }, { + "val" : "VHOG:0000068" + }, { + "val" : "Wikipedia:Neural_plate" + }, { + "val" : "XAO:0000249" + }, { + "val" : "ZFA:0000132" + }, { + "val" : "neuronames:1362" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002036", - "lbl" : "striated muscle tissue", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003076", + "lbl" : "posterior neural tube", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "AAO:0011082" + }, { + "val" : "TAO:0007037" + }, { + "val" : "VHOG:0001383" + }, { + "val" : "XAO:0000250" + }, { + "val" : "ZFA:0007037" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002040", - "lbl" : "bronchial artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003077", + "lbl" : "paraxial mesoderm", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].", + "xrefs" : [ "GO:0048339", "https://github.com/obophenotype/uberon/issues/30" ] + }, + "xrefs" : [ { + "val" : "AAO:0010568" + }, { + "val" : "EFO:0003515" + }, { + "val" : "EMAPA:16183" + }, { + "val" : "EMAPA:16751" + }, { + "val" : "FMA:293145" + }, { + "val" : "NCIT:C34244" + }, { + "val" : "SCTID:361475002" + }, { + "val" : "TAO:0000255" + }, { + "val" : "VHOG:0000114" + }, { + "val" : "Wikipedia:Paraxial_mesoderm" + }, { + "val" : "XAO:0000259" + }, { + "val" : "ZFA:0000255" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002047", - "lbl" : "pontine raphe nucleus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003078", + "lbl" : "epibranchial placode", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia.", + "xrefs" : [ "VHOG:0000117" ] + }, + "xrefs" : [ { + "val" : "AAO:0011036" + }, { + "val" : "EFO:0003455" + }, { + "val" : "FMA:293968" + }, { + "val" : "TAO:0001294" + }, { + "val" : "VHOG:0000117" + }, { + "val" : "XAO:0000284" + }, { + "val" : "ZFA:0001294" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002048", - "lbl" : "lung", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003080", + "lbl" : "anterior neural tube", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "AAO:0011012" + }, { + "val" : "TAO:0007038" + }, { + "val" : "VHOG:0001384" + }, { + "val" : "XAO:0000307" + }, { + "val" : "ZFA:0007038" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002049", - "lbl" : "vasculature", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003081", + "lbl" : "lateral plate mesoderm", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP].", + "xrefs" : [ "MP:0010117", "Wikipedia:Lateral_plate_mesoderm" ] + }, + "xrefs" : [ { + "val" : "AAO:0010574" + }, { + "val" : "EHDAA2:0000919" + }, { + "val" : "EHDAA:379" + }, { + "val" : "EMAPA:16179" + }, { + "val" : "FMA:293149" + }, { + "val" : "NCIT:C34199" + }, { + "val" : "SCTID:361477005" + }, { + "val" : "TAO:0000121" + }, { + "val" : "VHOG:0000118" + }, { + "val" : "Wikipedia:Lateral_plate_mesoderm" + }, { + "val" : "XAO:0000311" + }, { + "val" : "ZFA:0000121" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002050", - "lbl" : "embryonic structure", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003082", + "lbl" : "myotome", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells.", + "xrefs" : [ "AEO:0001018" ] + }, + "xrefs" : [ { + "val" : "AAO:0011067" + }, { + "val" : "AEO:0001018" + }, { + "val" : "BTO:0000742" + }, { + "val" : "EHDAA2_RETIRED:0003431" + }, { + "val" : "EHDAA:1721" + }, { + "val" : "EHDAA:1727" + }, { + "val" : "EHDAA:1733" + }, { + "val" : "EHDAA:1739" + }, { + "val" : "EMAPA:32841" + }, { + "val" : "FMA:295658" + }, { + "val" : "NCIT:C34214" + }, { + "val" : "SCTID:344535001" + }, { + "val" : "TAO:0001056" + }, { + "val" : "VHOG:0001244" + }, { + "val" : "Wikipedia:Myotome" + }, { + "val" : "XAO:0000315" + }, { + "val" : "ZFA:0001056" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002051", - "lbl" : "epithelium of bronchiole", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003083", + "lbl" : "trunk neural crest", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia].", + "xrefs" : [ "ISBN:0815318960", "Wikipedia:Trunk_neural_crest" ] + }, + "xrefs" : [ { + "val" : "AAO:0010582" + }, { + "val" : "EFO:0003605" + }, { + "val" : "EHDAA2:0001901" + }, { + "val" : "TAO:0001024" + }, { + "val" : "VHOG:0000062" + }, { + "val" : "Wikipedia:Trunk_neural_crest" + }, { + "val" : "XAO:0000319" + }, { + "val" : "ZFA:0001024" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002057", - "lbl" : "phrenic artery", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003084", + "lbl" : "heart primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011044" + }, { + "val" : "BTO:0001887" + }, { + "val" : "NCIT:C34276" + }, { + "val" : "TAO:0000028" + }, { + "val" : "XAO:0000336" + }, { + "val" : "ZFA:0000028" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002061", - "lbl" : "truncus arteriosus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "lbl" : "caudal artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Extension of the dorsal aorta in the tail.", + "xrefs" : [ "Wikipedia:Caudal_artery", "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0011023" + }, { + "val" : "EFO:0003472" + }, { + "val" : "TAO:0000011" + }, { + "val" : "VHOG:0000123" + }, { + "val" : "Wikipedia:Caudal_artery" + }, { + "val" : "XAO:0000364" + }, { + "val" : "ZFA:0000011" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002062", - "lbl" : "endocardial cushion", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003089", + "lbl" : "sclerotome", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].", + "xrefs" : [ "Wikipedia:Sclerotome", "XB:curator", "https://github.com/obophenotype/uberon/issues/316" ] + }, + "xrefs" : [ { + "val" : "AAO:0010571" + }, { + "val" : "AEO:0000212" + }, { + "val" : "EHDAA2:0003439" + }, { + "val" : "EMAPA:31159" + }, { + "val" : "FMA:295652" + }, { + "val" : "NCIT:C34287" + }, { + "val" : "TAO:0001080" + }, { + "val" : "VHOG:0000680" + }, { + "val" : "Wikipedia:Sclerotome" + }, { + "val" : "XAO:0000397" + }, { + "val" : "ZFA:0001080" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002063", - "lbl" : "sinus venosus", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003099", + "lbl" : "cranial neural crest", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage.", + "xrefs" : [ "MGI:anna" ] + }, + "xrefs" : [ { + "val" : "AAO:0010580" + }, { + "val" : "EFO:0003645" + }, { + "val" : "EHDAA2:0004420" + }, { + "val" : "EMAPA:16091" + }, { + "val" : "TAO:0001194" + }, { + "val" : "VHOG:0000063" + }, { + "val" : "Wikipedia:Cranial_neural_crest" + }, { + "val" : "XAO:0001001" + }, { + "val" : "ZFA:0001194" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002067", - "lbl" : "dermis", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003100", + "lbl" : "female organism", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Gonochoristic organism that can produce female gametes.", + "xrefs" : [ "CARO:0000028" ] + }, + "xrefs" : [ { + "val" : "AAO:0010030" + }, { + "val" : "BILA:0000028" + }, { + "val" : "CARO:0000028" + }, { + "val" : "FMA:67812" + }, { + "val" : "HAO:0000028" + }, { + "val" : "SCTID:362608006" + }, { + "val" : "TAO:0000303" + }, { + "val" : "TGMA:0001839" + }, { + "val" : "XAO:0003005" + }, { + "val" : "ZFA:0000303" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002072", - "lbl" : "hypodermis", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003102", + "lbl" : "surface structure", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/24" ] + }, + "xrefs" : [ { + "val" : "AAO:0010337" + }, { + "val" : "AEO_RETIRED:0000010" + }, { + "val" : "EHDAA2_RETIRED:0003010" + }, { + "val" : "TAO:0000292" + }, { + "val" : "VSAO:0000001" + }, { + "val" : "Wikipedia:Surface_structure" + }, { + "val" : "XAO:0003028" + }, { + "val" : "ZFA:0000292" + }, { + "val" : "galen:SurfaceRegion" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002075", - "lbl" : "viscus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002078", - "lbl" : "right cardiac atrium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003103", + "lbl" : "compound organ", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types.", + "xrefs" : [ "CARO:0000024" ] + }, + "xrefs" : [ { + "val" : "AAO:0010015" + }, { + "val" : "AEO:0000024" + }, { + "val" : "BILA:0000024" + }, { + "val" : "CARO:0000024" + }, { + "val" : "EHDAA2:0003024" + }, { + "val" : "HAO:0000024" + }, { + "val" : "TADS:0000598" + }, { + "val" : "TAO:0000496" + }, { + "val" : "TGMA:0001837" + }, { + "val" : "VHOG:0001723" + }, { + "val" : "XAO:0003041" + }, { + "val" : "ZFA:0000496" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002079", - "lbl" : "left cardiac atrium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003104", + "lbl" : "mesenchyme", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme.", + "xrefs" : [ "https://archive.org/details/invertebratesnde00brus/page/n240/mode/2up", "https://en.wikipedia.org/wiki/Mesenchyme", "https://github.com/obophenotype/uberon/issues/1641" ] + }, + "xrefs" : [ { + "val" : "AAO:0010427" + }, { + "val" : "AEO:0000145" + }, { + "val" : "BTO:0001393" + }, { + "val" : "CALOHA:TS-0620" + }, { + "val" : "EHDAA2:0003145" + }, { + "val" : "EV:0100007" + }, { + "val" : "NCIT:C13301" + }, { + "val" : "TAO:0000393" + }, { + "val" : "VHOG:0000170" + }, { + "val" : "Wikipedia:Mesenchyme" + }, { + "val" : "XAO:0003046" + }, { + "val" : "ZFA:0000393" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002080", - "lbl" : "heart right ventricle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003112", + "lbl" : "olfactory region", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ.", + "xrefs" : [ "TAO:0000351" ] + }, + "xrefs" : [ { + "val" : "AAO:0010206" + }, { + "val" : "EFO:0003525" + }, { + "val" : "NCIT:C98765" + }, { + "val" : "TAO:0000351" + }, { + "val" : "XAO:0003172" + }, { + "val" : "ZFA:0000351" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002081", - "lbl" : "cardiac atrium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002082", - "lbl" : "cardiac ventricle", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002084", - "lbl" : "heart left ventricle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003113", + "lbl" : "dermatocranium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified].", + "xrefs" : [ "Wikipedia:Skull_roof", "ZFA:0000863" ] + }, + "xrefs" : [ { + "val" : "AAO:0010154" + }, { + "val" : "TAO:0000863" + }, { + "val" : "VHOG:0001665" + }, { + "val" : "Wikipedia:Skull_roof" + }, { + "val" : "XAO:0003169" + }, { + "val" : "ZFA:0000863" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002085", - "lbl" : "interatrial septum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002090", - "lbl" : "postcranial axial skeleton", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002091", - "lbl" : "appendicular skeleton", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003115", + "lbl" : "pharyngeal arch 4", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus.", + "xrefs" : [ "MP:0006340" ] + }, + "xrefs" : [ { + "val" : "AAO:0010366" + }, { + "val" : "EHDAA2:0000086" + }, { + "val" : "EHDAA:1663" + }, { + "val" : "EMAPA:16760" + }, { + "val" : "FMA:293035" + }, { + "val" : "SCTID:308770007" + }, { + "val" : "TAO:0001599" + }, { + "val" : "VHOG:0000299" + }, { + "val" : "XAO:0000449" + }, { + "val" : "ZFA:0001607" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002094", - "lbl" : "interventricular septum", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003117", + "lbl" : "pharyngeal arch 6", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles.", + "xrefs" : [ "MP:0006347" ] + }, + "xrefs" : [ { + "val" : "AAO:0010368" + }, { + "val" : "EHDAA2:0004075" + }, { + "val" : "EMAPA:32766" + }, { + "val" : "FMA:293047" + }, { + "val" : "SCTID:308772004" + }, { + "val" : "TAO:0001601" + }, { + "val" : "VHOG:0001205" + }, { + "val" : "XAO:0000453" + }, { + "val" : "ZFA:0001609" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002097", - "lbl" : "skin of body", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003118", + "lbl" : "pharyngeal arch artery 1", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The vessels formed within the first pair of branchial arches in embryogenesis.", + "xrefs" : [ "MP:0010355" ] + }, + "xrefs" : [ { + "val" : "AAO:0010415" + }, { + "val" : "EHDAA2:0000007" + }, { + "val" : "EMAPA:16202" + }, { + "val" : "EMAPA:16685" + }, { + "val" : "SCTID:308774003" + }, { + "val" : "TAO:0005005" + }, { + "val" : "VHOG:0000149" + }, { + "val" : "XAO:0000342" + }, { + "val" : "ZFA:0005005" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002099", - "lbl" : "cardiac septum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002100", - "lbl" : "trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002104", - "lbl" : "visual system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002105", - "lbl" : "vestibulo-auditory system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002111", - "lbl" : "artery smooth muscle tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002112", - "lbl" : "smooth muscle of esophagus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002118", - "lbl" : "right ovary", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002119", - "lbl" : "left ovary", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002128", - "lbl" : "superior olivary complex", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002148", - "lbl" : "locus ceruleus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002149", - "lbl" : "superior salivatory nucleus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002165", - "lbl" : "endocardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002166", - "lbl" : "endocardium of atrium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002167", - "lbl" : "right lung", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002168", - "lbl" : "left lung", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002169", - "lbl" : "alveolar sac", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002173", - "lbl" : "pulmonary alveolar duct", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003121", + "lbl" : "pharyngeal arch artery 4", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The vessels formed within the fourth pair of branchial arches in embryogenesis.", + "xrefs" : [ "MP:0006354" ] + }, + "comments" : [ "proximal right subclavian" ], + "xrefs" : [ { + "val" : "AAO:0010420" + }, { + "val" : "EHDAA2:0000087" + }, { + "val" : "EMAPA:17004" + }, { + "val" : "SCTID:308777005" + }, { + "val" : "TAO:0005008" + }, { + "val" : "Wikipedia:Aortic_arches#Arch_4" + }, { + "val" : "XAO:0000355" + }, { + "val" : "ZFA:0005008" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002185", - "lbl" : "bronchus", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003123", + "lbl" : "pharyngeal arch artery 6", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The vessels formed within the sixth pair of branchial arches in embryogenesis.", + "xrefs" : [ "MP:0006355" ] + }, + "xrefs" : [ { + "val" : "AAO:0010422" + }, { + "val" : "EHDAA2:0000102" + }, { + "val" : "EMAPA:17005" + }, { + "val" : "SCTID:308779008" + }, { + "val" : "TAO:0005016" + }, { + "val" : "VHOG:0000144" + }, { + "val" : "Wikipedia:Aortic_arches#Arch_6" + }, { + "val" : "XAO:0000353" + }, { + "val" : "ZFA:0005016" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002186", - "lbl" : "bronchiole", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002187", - "lbl" : "terminal bronchiole", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003126", + "lbl" : "trachea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph].", + "xrefs" : [ "GO:0060438", "Wikipedia:Vertebrate_trachea" ] + }, + "xrefs" : [ { + "val" : "AAO:0010140" + }, { + "val" : "BTO:0001388" + }, { + "val" : "CALOHA:TS-1060" + }, { + "val" : "EFO:0000935" + }, { + "val" : "EHDAA2:0002066" + }, { + "val" : "EHDAA:3078" + }, { + "val" : "EMAPA:16853" + }, { + "val" : "EV:0100040" + }, { + "val" : "FMA:7394" + }, { + "val" : "GAID:361" + }, { + "val" : "MA:0000441" + }, { + "val" : "MAT:0000137" + }, { + "val" : "MESH:D014132" + }, { + "val" : "MIAA:0000137" + }, { + "val" : "NCIT:C12428" + }, { + "val" : "SCTID:181213009" + }, { + "val" : "VHOG:0000371" + }, { + "val" : "Wikipedia:Vertebrate_trachea" + }, { + "val" : "XAO:0000118" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002188", - "lbl" : "respiratory bronchiole", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003128", + "lbl" : "cranium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Upper portion of the skull that excludes the mandible (when present in the organism).", + "xrefs" : [ "Wikipedia:Cranium_(anatomy)", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001328" + }, { + "val" : "EFO:0000831" + }, { + "val" : "EHDAA:6029" + }, { + "val" : "FMA:71325" + }, { + "val" : "MA:0000316" + }, { + "val" : "MAT:0000340" + }, { + "val" : "MIAA:0000340" + }, { + "val" : "SCTID:181889008" + }, { + "val" : "VHOG:0000334" + }, { + "val" : "Wikipedia:Cranium_(anatomy)" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002190", - "lbl" : "subcutaneous adipose tissue", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003129", + "lbl" : "skull", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP].", + "xrefs" : [ "PMID:11523816", "Wikipedia:Skull", "http://sourceforge.net/tracker/?func=detail&aid=2962656&group_id=76834&atid=1205376" ] + }, + "xrefs" : [ { + "val" : "BTO:0001295" + }, { + "val" : "CALOHA:TS-2344" + }, { + "val" : "EHDAA2:0000325" + }, { + "val" : "EMAPA:17680" + }, { + "val" : "FMA:46565" + }, { + "val" : "GAID:82" + }, { + "val" : "MESH:D012886" + }, { + "val" : "NCIT:C12789" + }, { + "val" : "SCTID:110530005" + }, { + "val" : "Wikipedia:Skull" + }, { + "val" : "WikipediaCategory:Skull" + }, { + "val" : "galen:Skull" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002193", - "lbl" : "hemolymphoid system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002199", - "lbl" : "integument", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003133", + "lbl" : "reproductive organ", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An organ involved in reproduction.", + "xrefs" : [ "UBERON:xp" ] + }, + "xrefs" : [ { + "val" : "MA:0001752" + }, { + "val" : "MESH:D005835" + }, { + "val" : "NCIT:C25177" + }, { + "val" : "SCTID:128181006" + }, { + "val" : "TGMA:0000591" + }, { + "val" : "WBbt:0008422" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002200", - "lbl" : "vasculature of head", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002201", - "lbl" : "vasculature of trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002202", - "lbl" : "submucosa of trachea", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003134", + "lbl" : "female reproductive organ", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A female organ involved in reproduction.", + "xrefs" : [ "UBERON:xp" ] + }, + "xrefs" : [ { + "val" : "EMAPA:28540" + }, { + "val" : "MA:0000544" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002203", - "lbl" : "vasculature of eye", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003215", + "lbl" : "alveolus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Organ part that has the form of a hollow cavity[WP].", + "xrefs" : [ "Wikipedia:Alveolus" ] + }, + "xrefs" : [ { + "val" : "EFO:0002513" + }, { + "val" : "FMA:82493" + }, { + "val" : "NCIT:C12986" + }, { + "val" : "Wikipedia:Alveolus" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002204", - "lbl" : "musculoskeletal system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002213", - "lbl" : "cartilaginous joint", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002217", - "lbl" : "synovial joint", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002224", - "lbl" : "thoracic cavity", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003218", + "lbl" : "ovary septum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO].", + "xrefs" : [ "GO:0080126" ] + } + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002240", - "lbl" : "spinal cord", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003235", + "lbl" : "epithelium of upper jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelium that is part of a upper jaw [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002119" + }, { + "val" : "EHDAA:8027" + }, { + "val" : "EMAPA:18971" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002241", - "lbl" : "chondrocranium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002257", - "lbl" : "ventral horn of spinal cord", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002275", - "lbl" : "reticular formation", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002298", - "lbl" : "brainstem", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002299", - "lbl" : "alveolus of lung", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003236", + "lbl" : "epithelium of lower jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An epithelium that is part of a lower jaw [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001019" + }, { + "val" : "EHDAA:7999" + }, { + "val" : "EMAPA:35516" + }, { + "val" : "VHOG:0000802" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002302", - "lbl" : "myocardium of atrium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002308", - "lbl" : "nucleus of brain", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002315", - "lbl" : "gray matter of spinal cord", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002323", - "lbl" : "coelemic cavity lumen", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002324", - "lbl" : "muscle of back", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003257", + "lbl" : "yolk sac endoderm", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The portion of the yolk sac that is derived from endoderm and lines the yolk sac.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002215" + }, { + "val" : "EHDAA:166" + }, { + "val" : "EMAPA:16086" + }, { + "val" : "VHOG:0000626" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002328", - "lbl" : "notochord", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002329", - "lbl" : "somite", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002330", - "lbl" : "exocrine system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002333", - "lbl" : "pulmonary trunk", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003258", + "lbl" : "endoderm of foregut", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endoderm that is part of a foregut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004568" + }, { + "val" : "EHDAA:524" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002338", - "lbl" : "lamina propria of bronchus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002342", - "lbl" : "neural crest", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002343", - "lbl" : "abdomen musculature", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002345", - "lbl" : "descending thoracic aorta", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003259", + "lbl" : "endoderm of midgut", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endoderm that is part of a midgut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:987" + }, { + "val" : "EMAPA:16257" + }, { + "val" : "RETIRED_EHDAA2:0001194" + }, { + "val" : "VHOG:0001080" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002346", - "lbl" : "neurectoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002348", - "lbl" : "epicardium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003260", + "lbl" : "endoderm of hindgut", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endoderm that is part of a hindgut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:979" + }, { + "val" : "RETIRED_EHDAA2:0000781" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002349", - "lbl" : "myocardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002350", - "lbl" : "conducting system of heart", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002351", - "lbl" : "sinoatrial node", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003269", + "lbl" : "skeletal muscle tissue of eye", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000486" + }, { + "val" : "EHDAA:2923" + }, { + "val" : "EMAPA:17844" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002352", - "lbl" : "atrioventricular node", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "lbl" : "skeleton of upper jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000622" + }, { + "val" : "EHDAA2:0002128" + }, { + "val" : "EHDAA:8041" + }, { + "val" : "EMAPA:17927" + }, { + "val" : "FMA:54397" + }, { + "val" : "MA:0001908" + }, { + "val" : "VHOG:0000429" + }, { + "val" : "XAO:0003087" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002354", - "lbl" : "cardiac Purkinje fiber", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002357", - "lbl" : "serous pericardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002358", - "lbl" : "peritoneum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002359", - "lbl" : "fibrous pericardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002365", - "lbl" : "exocrine gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002368", - "lbl" : "endocrine gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002371", - "lbl" : "bone marrow", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003278", + "lbl" : "skeleton of lower jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000274" + }, { + "val" : "EHDAA2:0004606" + }, { + "val" : "EHDAA:8005" + }, { + "val" : "EMAPA:17910" + }, { + "val" : "FMA:54398" + }, { + "val" : "MA:0001906" + }, { + "val" : "TAO:0001273" + }, { + "val" : "VHOG:0000428" + }, { + "val" : "XAO:0003084" + }, { + "val" : "ZFA:0001273" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002376", - "lbl" : "cranial muscle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003279", + "lbl" : "endothelium of trachea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelium that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:3082" + }, { + "val" : "RETIRED_EHDAA2:0002068" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002377", - "lbl" : "muscle of neck", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003281", + "lbl" : "mesentery of stomach", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/mesogastrium" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001922" + }, { + "val" : "EHDAA:2999" + }, { + "val" : "EMAPA:17024" + }, { + "val" : "MA:0001617" + }, { + "val" : "SCTID:261623000" + }, { + "val" : "VHOG:0000358" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002378", - "lbl" : "muscle of abdomen", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003282", + "lbl" : "mesentery of heart", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mesentery that surrounds the heart.", + "xrefs" : [ "MA:th" ] + }, + "xrefs" : [ { + "val" : "EHDAA:432" + }, { + "val" : "EMAPA:16212" + }, { + "val" : "RETIRED_EHDAA2:0000739" + }, { + "val" : "VHOG:0000353" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002384", - "lbl" : "connective tissue", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003283", + "lbl" : "mesentery of oesophagus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mesentery that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001288" + }, { + "val" : "EHDAA:2943" + }, { + "val" : "EMAPA:16836" + }, { + "val" : "MA:0001569" + }, { + "val" : "VHOG:0000415" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002385", - "lbl" : "muscle tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002390", - "lbl" : "hematopoietic system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003284", + "lbl" : "mesentery of midgut", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A mesentery that is part of a midgut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001202" + }, { + "val" : "EHDAA:3031" + }, { + "val" : "EMAPA:16721" + }, { + "val" : "EMAPA:17039" + }, { + "val" : "EMAPA:17197" + }, { + "val" : "VHOG:0000413" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002400", - "lbl" : "parietal pleura", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002401", - "lbl" : "visceral pleura", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003294", + "lbl" : "gland of foregut", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland that is part of a foregut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000567" + }, { + "val" : "EHDAA:950" + }, { + "val" : "EMAPA:16557" + }, { + "val" : "VHOG:0000650" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002402", - "lbl" : "pleural cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002405", - "lbl" : "immune system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003295", + "lbl" : "pharyngeal gland", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Racemose mucous glands beneath the mucous membrane of the pharynx.", + "xrefs" : [ "http://www.biology-online.org/dictionary/" ] + }, + "xrefs" : [ { + "val" : "BTO:0004849" + }, { + "val" : "EHDAA2:0001461" + }, { + "val" : "EHDAA:2967" + }, { + "val" : "FMA:55075" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002406", - "lbl" : "pericardial sac", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002407", - "lbl" : "pericardium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003297", + "lbl" : "gland of integumental system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gland that is part of a integumental system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000837" + }, { + "val" : "EMAPA:17758" + }, { + "val" : "MA:0000144" + }, { + "val" : "VHOG:0000654" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002408", - "lbl" : "parietal serous pericardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002409", - "lbl" : "pericardial fluid", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002410", - "lbl" : "autonomic nervous system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002416", - "lbl" : "integumental system", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003304", + "lbl" : "mesoderm blood island", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A blood island that is part of a mesoderm.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0003241" + }, { + "val" : "EHDAA:170" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002417", - "lbl" : "abdominal segment of trunk", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002418", - "lbl" : "cartilage tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002419", - "lbl" : "skin gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002424", - "lbl" : "oral epithelium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002425", - "lbl" : "visceral serous pericardium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002443", - "lbl" : "choroidal blood vessel", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002457", - "lbl" : "intersomitic artery", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002458", - "lbl" : "spinal artery", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002469", - "lbl" : "esophagus mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002481", - "lbl" : "bone tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002506", - "lbl" : "iris epithelium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003314", + "lbl" : "eye mesenchyme", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Mesenchyme that is part of a developing camera-type eye.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000485" + }, { + "val" : "EHDAA:2910" + }, { + "val" : "EMAPA:16673" + }, { + "val" : "VHOG:0001084" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002513", - "lbl" : "endochondral bone", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002514", - "lbl" : "intramembranous bone", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002521", - "lbl" : "elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002522", - "lbl" : "tunica media", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002523", - "lbl" : "tunica intima", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002530", - "lbl" : "gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002532", - "lbl" : "epiblast (generic)", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002536", - "lbl" : "arthropod sensillum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002539", - "lbl" : "pharyngeal arch", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002546", - "lbl" : "cranial placode", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002553", - "lbl" : "anatomical cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002616", - "lbl" : "regional part of brain", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002726", - "lbl" : "cervical spinal cord", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003315", + "lbl" : "mesenchyme of ovary", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Mesenchyme that is part of a developing ovary [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001362" + }, { + "val" : "EHDAA:8128" + }, { + "val" : "VHOG:0001441" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0002925", - "lbl" : "trigeminal nucleus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003023", - "lbl" : "pontine tegmentum", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003316", + "lbl" : "mesenchyme of yolk sac", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002216" + }, { + "val" : "EHDAA:168" + }, { + "val" : "EHDAA:205" + }, { + "val" : "EMAPA:16087" + }, { + "val" : "EMAPA:16267" + }, { + "val" : "VHOG:0000503" + }, { + "val" : "VHOG:0000617" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003037", - "lbl" : "septum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003038", - "lbl" : "thoracic spinal cord", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "lbl" : "mesenchyme of upper jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Mesenchyme that is part of a developing upper jaw [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002124" + }, { + "val" : "EHDAA:8031" + }, { + "val" : "EMAPA:17929" + }, { + "val" : "VHOG:0001099" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003052", - "lbl" : "midbrain-hindbrain boundary", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003055", - "lbl" : "periderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003056", - "lbl" : "pre-chordal neural plate", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003057", - "lbl" : "chordal neural plate", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003059", - "lbl" : "presomitic mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003061", - "lbl" : "blood island", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003063", - "lbl" : "prechordal plate", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003064", - "lbl" : "intermediate mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003067", - "lbl" : "dorsolateral placode", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003068", - "lbl" : "axial mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003070", - "lbl" : "trigeminal placode complex", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003071", - "lbl" : "eye primordium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003072", - "lbl" : "optic cup", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003073", - "lbl" : "lens placode", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003075", - "lbl" : "neural plate", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003076", - "lbl" : "posterior neural tube", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003077", - "lbl" : "paraxial mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003078", - "lbl" : "epibranchial placode", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003080", - "lbl" : "anterior neural tube", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003081", - "lbl" : "lateral plate mesoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003082", - "lbl" : "myotome", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003083", - "lbl" : "trunk neural crest", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003084", - "lbl" : "heart primordium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003089", - "lbl" : "sclerotome", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003099", - "lbl" : "cranial neural crest", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003100", - "lbl" : "female organism", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003102", - "lbl" : "surface structure", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003103", - "lbl" : "compound organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003104", - "lbl" : "mesenchyme", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003113", - "lbl" : "dermatocranium", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003115", - "lbl" : "pharyngeal arch 4", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003117", - "lbl" : "pharyngeal arch 6", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003118", - "lbl" : "pharyngeal arch artery 1", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003121", - "lbl" : "pharyngeal arch artery 4", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003123", - "lbl" : "pharyngeal arch artery 6", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003126", - "lbl" : "trachea", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003324", + "lbl" : "mesenchyme of lower jaw", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Mesenchyme that is part of a developing lower jaw [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001024" + }, { + "val" : "EHDAA:8003" + }, { + "val" : "EMAPA:17916" + }, { + "val" : "VHOG:0001069" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003128", - "lbl" : "cranium", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003329", + "lbl" : "submucosa of anal canal", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7762" + "definition" : { + "val" : "A submucosa that is part of an anal canal [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27217" + }, { + "val" : "EMAPA:27227" + }, { + "val" : "EMAPA:27535" + }, { + "val" : "FMA:85399" + }, { + "val" : "SCTID:7892006" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003129", - "lbl" : "skull", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003133", - "lbl" : "reproductive organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003134", - "lbl" : "female reproductive organ", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003215", - "lbl" : "alveolus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003218", - "lbl" : "ovary septum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003236", - "lbl" : "epithelium of lower jaw", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003257", - "lbl" : "yolk sac endoderm", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003258", - "lbl" : "endoderm of foregut", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003269", - "lbl" : "skeletal muscle tissue of eye", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003278", - "lbl" : "skeleton of lower jaw", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003279", - "lbl" : "endothelium of trachea", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003294", - "lbl" : "gland of foregut", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003295", - "lbl" : "pharyngeal gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003297", - "lbl" : "gland of integumental system", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003330", + "lbl" : "submucosa of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The submucous layer of the wall of the rectum.", + "xrefs" : [ "BTO:0002114" ] + }, + "xrefs" : [ { + "val" : "BTO:0002114" + }, { + "val" : "EMAPA:27083" + }, { + "val" : "FMA:15034" + }, { + "val" : "SCTID:71683001" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003304", - "lbl" : "mesoderm blood island", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003331", + "lbl" : "submucosa of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27379" + }, { + "val" : "FMA:14985" + }, { + "val" : "MA:0003200" + }, { + "val" : "SCTID:61647009" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003314", - "lbl" : "eye mesenchyme", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003332", + "lbl" : "submucosa of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a duodenum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27027" + }, { + "val" : "EMAPA:27097" + }, { + "val" : "EMAPA:27239" + }, { + "val" : "FMA:14943" + }, { + "val" : "MA:0003213" + }, { + "val" : "SCTID:76519004" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003315", - "lbl" : "mesenchyme of ovary", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003334", + "lbl" : "serosa of rectum", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A serous membrane that is part of a rectum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27087" + }, { + "val" : "FMA:15039" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003316", - "lbl" : "mesenchyme of yolk sac", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003335", + "lbl" : "serosa of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27387" + }, { + "val" : "FMA:14990" + }, { + "val" : "MA:0003199" + }, { + "val" : "SCTID:90132000" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003324", - "lbl" : "mesenchyme of lower jaw", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003336", + "lbl" : "serosa of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a duodenum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27247" + }, { + "val" : "FMA:14948" + }, { + "val" : "MA:0003212" + }, { + "val" : "SCTID:1236009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003338", "lbl" : "ganglion of peripheral nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO).", + "xrefs" : [ "BIRNLEX:2548" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:2548" + }, { + "val" : "BTO:0001123" + }, { + "val" : "EMAPA:32814" + }, { + "val" : "MA:0001161" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003339", "lbl" : "ganglion of central nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ganglion that is part of a central nervous system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000227" + }, { + "val" : "EMAPA:16658" + }, { + "val" : "FMA:83843" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003342", + "lbl" : "mucosa of anal canal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of an anal canal [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27531" + }, { + "val" : "FMA:74654" + }, { + "val" : "NCIT:C60784" + }, { + "val" : "SCTID:362170004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003343", "lbl" : "mucosa of oral region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a oral opening [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:362083000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003346", + "lbl" : "mucosa of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a rectum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2107" + }, { + "val" : "EMAPA:27081" + }, { + "val" : "FMA:15033" + }, { + "val" : "MA:0003218" + }, { + "val" : "SCTID:362167003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003350", "lbl" : "epithelium of mucosa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of epithelial cells on the surface of the mucosa.", + "xrefs" : [ "BTO:0003752" ] + }, + "comments" : [ "lies on top of lamina propria" ], + "xrefs" : [ { + "val" : "BTO:0003752" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003351", "lbl" : "pharyngeal epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a pharynx [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BSA:0000112" + }, { + "val" : "BTO:0005240" + }, { + "val" : "EMAPA:16708" + }, { + "val" : "MA:0002725" + }, { + "val" : "RETIRED_EHDAA2:0001460" + }, { + "val" : "TAO:0001174" + }, { + "val" : "XAO:0003202" + }, { + "val" : "ZFA:0001174" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003352", + "lbl" : "epithelium of midgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a midgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0005053" + }, { + "val" : "EHDAA2:0001195" + }, { + "val" : "EMAPA:16569" + }, { + "val" : "MA:0003205" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003353", + "lbl" : "epithelium of hindgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a hindgut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000782" + }, { + "val" : "EMAPA:16717" + }, { + "val" : "MA:0003206" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003354", + "lbl" : "epithelium of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a rectum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2066" + }, { + "val" : "EHDAA2:0001594" + }, { + "val" : "EMAPA:17898" + }, { + "val" : "FMA:17510" + }, { + "val" : "MA:0003219" + }, { + "val" : "VHOG:0001037" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003364", "lbl" : "epithelium of right lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17663" + }, { + "val" : "MA:0003132" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003365", "lbl" : "epithelium of left lung", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17655" + }, { + "val" : "MA:0003131" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003372", "lbl" : "pectoral appendage bud ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An unilaminar epithelium that surrounds a pectoral appendage bud.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002134" + }, { + "val" : "EMAPA:16407" + }, { + "val" : "VHOG:0001047" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003379", "lbl" : "cardiac muscle of right atrium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004155" + }, { + "val" : "EMAPA:17326" + }, { + "val" : "FMA:7282" + }, { + "val" : "SCTID:362018002" + }, { + "val" : "VHOG:0001227" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003380", "lbl" : "cardiac muscle of left atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004154" + }, { + "val" : "EMAPA:17320" + }, { + "val" : "FMA:7285" + }, { + "val" : "SCTID:189936008" + }, { + "val" : "VHOG:0001225" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003381", "lbl" : "cardiac muscle of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17342" + }, { + "val" : "FMA:83452" + }, { + "val" : "VHOG:0001236" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003382", "lbl" : "cardiac muscle of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17339" + }, { + "val" : "FMA:83453" + }, { + "val" : "VHOG:0001234" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003383", "lbl" : "cardiac muscle tissue of interventricular septum", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004158" + }, { + "val" : "EMAPA:17335" + }, { + "val" : "FMA:84084" + }, { + "val" : "VHOG:0000999" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003384", "lbl" : "skeletal muscle tissue of pharynx", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18963" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003386", "lbl" : "smooth muscle of eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi.", + "xrefs" : [ "MGI:cwg", "MP:0005247" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18807" + }, { + "val" : "MA:0001268" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003387", "lbl" : "smooth muscle of trachea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001391" + }, { + "val" : "EMAPA:19192" + }, { + "val" : "FMA:262010" + }, { + "val" : "MA:0001863" + }, { + "val" : "NCIT:C49306" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003388", "lbl" : "mesothelium of pericardial cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelium that is part of a pericardium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "RETIRED_EHDAA2:0001436" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003389", "lbl" : "mesothelium of diaphragm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelium that is part of a diaphragm [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18429" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003390", "lbl" : "mesothelium of pleural cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelium that is part of a pleural cavity [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0003155" + }, { + "val" : "EHDAA2:0001476" + }, { + "val" : "EMAPA:16775" + }, { + "val" : "FMA:18148" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003393", + "lbl" : "mesentery of urinary system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a urinary system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17367" + }, { + "val" : "MA:0003233" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003394", + "lbl" : "mesentery of hindgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a hindgut [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16718" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003395", + "lbl" : "mesentery of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a rectum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18664" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003396", + "lbl" : "mesentery of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18942" + }, { + "val" : "FMA:14645" + }, { + "val" : "SCTID:245457004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003397", + "lbl" : "mesentery of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a duodenum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19081" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003406", "lbl" : "cartilage of respiratory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage element that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18694" + }, { + "val" : "MA:0001818" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003408", "lbl" : "gland of digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a digestive tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18815" + }, { + "val" : "MA:0003202" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003413", "lbl" : "pectoral appendage bud mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a pectoral appendage bud.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002135" + }, { + "val" : "EHDAA:1703" + }, { + "val" : "EMAPA:16408" + }, { + "val" : "TAO:0000789" + }, { + "val" : "ZFA:0000789" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003426", "lbl" : "dermis adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adipose tissue that is part of a dermis [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000798" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003429", "lbl" : "abdomen nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of an abdomen [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000521" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003430", "lbl" : "neck nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000588" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003438", "lbl" : "iris nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any nerve that innervates the iris.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35449" + }, { + "val" : "MA:0001291" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003439", "lbl" : "nerve of trunk region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000515" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003443", "lbl" : "thoracic cavity nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is located in a thoracic cavity [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000556" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003452", + "lbl" : "trabecula carnea cardiac muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36573" + }, { + "val" : "FMA:84428" + }, { + "val" : "MA:0002833" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003457", "lbl" : "head bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "Different sources vary regarding which bones are craniofacial; e.g. hyoid bone" ], + "xrefs" : [ { + "val" : "EMAPA:35996" + }, { + "val" : "MA:0000576" + }, { + "val" : "SCTID:118646007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003458", "lbl" : "neck bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000584" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003462", "lbl" : "facial bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a facial skeleton [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19019" + }, { + "val" : "EMAPA:35924" + }, { + "val" : "MA:0001482" + }, { + "val" : "MA:0003159" + }, { + "val" : "NCIT:C63706" + }, { + "val" : "SCTID:181799005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003463", "lbl" : "trunk bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36583" + }, { + "val" : "MA:0000512" + }, { + "val" : "SCTID:427358002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003469", "lbl" : "respiratory system artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001804" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "lbl" : "artery of upper lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose.", + "xrefs" : [ "Wikipedia:Superior_labial_artery" ] + }, + "xrefs" : [ { + "val" : "FMA:49570" + }, { + "val" : "MA:0001917" + }, { + "val" : "SCTID:145137009" + }, { + "val" : "Wikipedia:Superior_labial_artery" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003471", "lbl" : "artery of lower lip", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery.", + "xrefs" : [ "Wikipedia:Inferior_labial_artery" ] + }, + "xrefs" : [ { + "val" : "FMA:49567" + }, { + "val" : "MA:0001916" + }, { + "val" : "SCTID:145036002" + }, { + "val" : "Wikipedia:Inferior_labial_artery" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003473", "lbl" : "thoracic cavity artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that is part of a thoracic cavity[cjm].", + "xrefs" : [ "https://sourceforge.net/tracker/index.php?func=detail&aid=3317815&group_id=76834&atid=1205376" ] + }, + "xrefs" : [ { + "val" : "MA:0001902" + }, { + "val" : "MESH:D013895" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003476", "lbl" : "respiratory system venous blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001809" + }, { + "val" : "MA:0001810" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003477", + "lbl" : "vein of upper lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The inferior labial vein is the vein receiving blood from the upper lip.", + "xrefs" : [ "Wikipedia:Superior_labial_vein" ] + }, + "xrefs" : [ { + "val" : "FMA:52538" + }, { + "val" : "MA:0002255" + }, { + "val" : "SCTID:422755007" + }, { + "val" : "Wikipedia:Superior_labial_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003478", "lbl" : "vein of lower lip", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The inferior labial vein is the vein receiving blood from the lower lip.", + "xrefs" : [ "Wikipedia:Inferior_labial_vein" ] + }, + "xrefs" : [ { + "val" : "FMA:52541" + }, { + "val" : "MA:0002253" + }, { + "val" : "SCTID:422955002" + }, { + "val" : "Wikipedia:Inferior_labial_vein" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003479", "lbl" : "thoracic cavity vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a thoracic cavity [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001903" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003481", + "lbl" : "tail vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a tail [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic", "Wikipedia:Tail_vein" ] + }, + "xrefs" : [ { + "val" : "AAO:0011105" + }, { + "val" : "MA:0002233" + }, { + "val" : "Wikipedia:Tail_vein" + }, { + "val" : "XAO:0000393" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003489", "lbl" : "respiratory system capillary endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium of capillary that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001808" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003494", "lbl" : "respiratory system venule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A venule that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001813" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003495", "lbl" : "respiratory system arteriole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arteriole that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001803" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003496", "lbl" : "head blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36610" + }, { + "val" : "MA:0000575" + }, { + "val" : "SCTID:127865000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003497", "lbl" : "abdomen blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of an abdomen [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000518" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003498", "lbl" : "heart blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a heart [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35397" + }, { + "val" : "MA:0002483" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003499", "lbl" : "brain blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a brain [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35182" + }, { + "val" : "MA:0002769" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003500", "lbl" : "corneal blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a cornea [Automatically generated definition].", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/tracker/index.php?func=detail&aid=3564332&group_id=36855&atid=440764" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36611" + }, { + "val" : "MA:0001241" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003501", "lbl" : "retina blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a retina [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36520" + }, { + "val" : "GAID:509" + }, { + "val" : "MA:0001317" + }, { + "val" : "MESH:D012171" + }, { + "val" : "SCTID:280692003" + }, { + "val" : "XAO:0004153" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003502", "lbl" : "neck blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000583" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003504", "lbl" : "respiratory system blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35731" + }, { + "val" : "EMAPA:35995" + }, { + "val" : "MA:0001799" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003505", "lbl" : "trachea blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35874" + }, { + "val" : "MA:0001852" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003509", "lbl" : "arterial blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "only in MA - supertype of artery, arteriole, aorta." ], + "xrefs" : [ { + "val" : "EMAPA:35144" + }, { + "val" : "MA:0000061" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003511", "lbl" : "iris blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a iris [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001290" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003512", "lbl" : "lung blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32867" + }, { + "val" : "MA:0002457" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003513", "lbl" : "trunk blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000511" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003519", "lbl" : "thoracic cavity blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a thoracic cavity [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000554" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003524", + "lbl" : "tail blood vessel", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a tail [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35848" + }, { + "val" : "MA:0000695" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003526", "lbl" : "respiratory system capillary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001807" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003528", "lbl" : "brain gray matter", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gray matter that is part of a brain [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35184" + }, { + "val" : "MA:0000810" + }, { + "val" : "NCIT:C49333" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003534", + "lbl" : "tail skin", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a tail [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36502" + }, { + "val" : "MA:0000700" + }, { + "val" : "SCTID:67214004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003536", "lbl" : "right lung alveolar duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An alveolar duct that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35819" + }, { + "val" : "MA:0001785" + }, { + "val" : "NCIT:C49277" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003537", "lbl" : "left lung alveolar duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An alveolar duct that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "Mice have 1 left lobe" ], + "xrefs" : [ { + "val" : "EMAPA:19183" + }, { + "val" : "MA:0001776" + }, { + "val" : "NCIT:C49250" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003538", "lbl" : "right lung bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bronchiole that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35425" + }, { + "val" : "MA:0001787" + }, { + "val" : "NCIT:C49279" + }, { + "val" : "SCTID:200089000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003539", "lbl" : "left lung bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bronchiole that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19000" + }, { + "val" : "MA:0001778" + }, { + "val" : "NCIT:C49252" + }, { + "val" : "SCTID:200484003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003540", "lbl" : "right lung terminal bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A terminal bronchiole that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36638" + }, { + "val" : "MA:0001789" + }, { + "val" : "NCIT:C49294" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003541", "lbl" : "left lung terminal bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A terminal bronchiole that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36636" + }, { + "val" : "MA:0001780" + }, { + "val" : "NCIT:C49255" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003542", "lbl" : "right lung respiratory bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A respiratory bronchiole that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36637" + }, { + "val" : "MA:0001788" + }, { + "val" : "NCIT:C49285" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003543", "lbl" : "left lung respiratory bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A respiratory bronchiole that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36635" + }, { + "val" : "MA:0001779" + }, { + "val" : "NCIT:C49254" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003566", "lbl" : "head connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000577" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003567", "lbl" : "abdomen connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of an abdomen [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000519" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003568", "lbl" : "neck connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000585" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003570", "lbl" : "respiratory system connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35968" + }, { + "val" : "EMAPA:35977" + }, { + "val" : "MA:0001814" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003571", "lbl" : "trachea connective tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of connective tissue that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35876" + }, { + "val" : "MA:0001853" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003580", "lbl" : "lower respiratory tract connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002409" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003585", "lbl" : "dermis connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a dermis [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36509" + }, { + "val" : "MA:0000799" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003586", "lbl" : "trunk connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000513" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003592", "lbl" : "bronchus connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32690" + }, { + "val" : "EMAPA:35193" + }, { + "val" : "MA:0001831" + }, { + "val" : "NCIT:C49210" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003593", "lbl" : "thoracic cavity connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000555" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003599", + "lbl" : "tail connective tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a tail [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16749" + }, { + "val" : "MA:0000697" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003601", "lbl" : "neck cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000586" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003603", "lbl" : "lower respiratory tract cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage that is part of a lower respiratory tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001819" + }, { + "val" : "NCIT:C49256" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003604", "lbl" : "trachea cartilage", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The ring-shaped cartilaginous structures that support the trachea.", + "xrefs" : [ "J:97123", "MGI:smb", "MP:0003120", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18699" + }, { + "val" : "EMAPA:35875" + }, { + "val" : "FMA:7434" + }, { + "val" : "MA:0001857" + }, { + "val" : "NCIT:C49304" + }, { + "val" : "SCTID:278979006" + }, { + "val" : "Wikipedia:Tracheal_rings" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003605", + "lbl" : "eye skin gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skin gland that is part of a camera-type eye [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002451" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003609", + "lbl" : "aorta elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall.", + "xrefs" : [ "MP:0009862" ] + }, + "xrefs" : [ { + "val" : "MA:0002859" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003610", + "lbl" : "heart elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers.", + "xrefs" : [ "MP:0009863" ] + }, + "xrefs" : [ { + "val" : "MA:0002858" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003611", + "lbl" : "respiratory system elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An elastic tissue that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001820" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003613", + "lbl" : "cardiovascular system elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An elastic tissue that is part of a circulatory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002857" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003614", + "lbl" : "blood vessel elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Elastic tissue layer that lines a blood vessel layer.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "https://sourceforge.net/p/obo/mammalian-phenotype-requests/2026/" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36300" + }, { + "val" : "MA:0002856" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003615", + "lbl" : "lung elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Elastic tissue that is part of a lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002860" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003616", + "lbl" : "bronchus elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An elastic tissue that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001838" + }, { + "val" : "NCIT:C49211" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003617", + "lbl" : "trachea elastic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An elastic tissue that is part of a trachea [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001861" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003618", + "lbl" : "aorta tunica media", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers.", + "xrefs" : [ "MP:0009873" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35138" + }, { + "val" : "FMA:74433" + }, { + "val" : "MA:0002903" + }, { + "val" : "SCTID:48467007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003619", + "lbl" : "aorta tunica intima", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The innermost layer of the aorta, containing the endothelium and an inner elastic membrane.", + "xrefs" : [ "MP:0009872" ] + }, + "xrefs" : [ { + "val" : "BTO:0005553" + }, { + "val" : "EMAPA:35137" + }, { + "val" : "FMA:74419" + }, { + "val" : "MA:0002904" + }, { + "val" : "SCTID:362031007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003643", + "lbl" : "respiratory system arterial blood vessel", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arterial blood vessel that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001800" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003665", + "lbl" : "post-anal tail muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle organ that attaches to a tail vertebra [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000081" + }, { + "val" : "BTO:0001905" + }, { + "val" : "MA:0000699" + }, { + "val" : "SCTID:113230005" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003684", + "lbl" : "abdominal cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity).", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "EFO:0000213" + }, { + "val" : "EMAPA:36505" + }, { + "val" : "FMA:12266" + }, { + "val" : "GAID:17" + }, { + "val" : "MA:0003057" + }, { + "val" : "MESH:D034841" + }, { + "val" : "NCIT:C12664" + }, { + "val" : "SCTID:361294009" + }, { + "val" : "Wikipedia:Abdominal_cavity" + }, { + "val" : "galen:AbdominalCavity" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003687", + "lbl" : "foramen magnum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Foramen_magnum" ] + }, + "comments" : [ "Design pattern notes: check whether this fits the foramen design pattern" ], + "xrefs" : [ { + "val" : "AAO:0010826" + }, { + "val" : "FMA:75306" + }, { + "val" : "GAID:228" + }, { + "val" : "MESH:D005539" + }, { + "val" : "NCIT:C12495" + }, { + "val" : "SCTID:244679008" + }, { + "val" : "TAO:0002045" + }, { + "val" : "Wikipedia:Foramen_magnum" + }, { + "val" : "ZFA:0005387" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "lbl" : "atlanto-axial joint", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas.", + "xrefs" : [ "Wikipedia:Atlanto-axial_joint" ] + }, + "xrefs" : [ { + "val" : "FMA:25524" + }, { + "val" : "GAID:250" + }, { + "val" : "MESH:D001268" + }, { + "val" : "NCIT:C32157" + }, { + "val" : "SCTID:361832004" + }, { + "val" : "Wikipedia:Atlanto-axial_joint" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003697", + "lbl" : "abdominal wall", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles.", + "xrefs" : [ "ncithesaurus:Abdominal_Wall" ] + }, + "xrefs" : [ { + "val" : "FMA:10429" + }, { + "val" : "FMA:259054" + }, { + "val" : "GAID:26" + }, { + "val" : "MESH:D034861" + }, { + "val" : "NCIT:C77608" + }, { + "val" : "SCTID:181613000" + }, { + "val" : "Wikipedia:Abdominal_wall" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003605", - "lbl" : "eye skin gland", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003609", - "lbl" : "aorta elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003610", - "lbl" : "heart elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003611", - "lbl" : "respiratory system elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003613", - "lbl" : "cardiovascular system elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003614", - "lbl" : "blood vessel elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003615", - "lbl" : "lung elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003616", - "lbl" : "bronchus elastic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003617", - "lbl" : "trachea elastic tissue", + "id" : "http://purl.obolibrary.org/obo/UBERON_0003703", + "lbl" : "extrahepatic bile duct", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct.", + "xrefs" : [ "MESH:A03.159.183.079" ] + }, + "xrefs" : [ { + "val" : "FMA:14678" + }, { + "val" : "GAID:281" + }, { + "val" : "MA:0002659" + }, { + "val" : "MESH:D017734" + }, { + "val" : "NCIT:C32573" + }, { + "val" : "SCTID:276158002" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003618", - "lbl" : "aorta tunica media", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003619", - "lbl" : "aorta tunica intima", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003643", - "lbl" : "respiratory system arterial blood vessel", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003684", - "lbl" : "abdominal cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003687", - "lbl" : "foramen magnum", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0003697", - "lbl" : "abdominal wall", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0003704", + "lbl" : "intrahepatic bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.", + "xrefs" : [ "MESH:A03.159.183.158" ] + }, + "xrefs" : [ { + "val" : "FMA:15766" + }, { + "val" : "GAID:287" + }, { + "val" : "MA:0001630" + }, { + "val" : "MESH:D001653" + }, { + "val" : "NCIT:C12677" + }, { + "val" : "SCTID:362193005" + }, { + "val" : "TAO:0005169" + }, { + "val" : "ZFA:0005169" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003711", "lbl" : "brachiocephalic vein", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava.", + "xrefs" : [ "Wikipedia:Brachiocephalic_vein" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000182" + }, { + "val" : "EHDAA:9868" + }, { + "val" : "FMA:4723" + }, { + "val" : "GAID:529" + }, { + "val" : "MESH:D016121" + }, { + "val" : "NCIT:C32816" + }, { + "val" : "SCTID:181371003" + }, { + "val" : "Wikipedia:Brachiocephalic_vein" + }, { + "val" : "galen:BrachiocephalicVein" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003713", + "lbl" : "splenic vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein.", + "xrefs" : [ "ncithesaurus:Splenic_Vein" ] + }, + "xrefs" : [ { + "val" : "FMA:14331" + }, { + "val" : "GAID:541" + }, { + "val" : "MA:0002164" + }, { + "val" : "MESH:D013162" + }, { + "val" : "NCIT:C33608" + }, { + "val" : "SCTID:278029005" + }, { + "val" : "Wikipedia:Splenic_vein" + }, { + "val" : "galen:SplenicVein" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003714", "lbl" : "neural tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature.", + "xrefs" : [ "FMA:9642" ] + }, + "xrefs" : [ { + "val" : "AAO:0000325" + }, { + "val" : "AEO:0000123" + }, { + "val" : "EHDAA2:0003123" + }, { + "val" : "FMA:9642" + }, { + "val" : "GAID:609" + }, { + "val" : "MESH:D009417" + }, { + "val" : "NCIT:C13052" + }, { + "val" : "SCTID:91728009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003715", "lbl" : "splanchnic nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia.", + "xrefs" : [ "MP:0008318" ] + }, + "xrefs" : [ { + "val" : "BAMS:spn" + }, { + "val" : "FMA:5883" + }, { + "val" : "GAID:800" + }, { + "val" : "MESH:D013153" + }, { + "val" : "SCTID:264198001" + }, { + "val" : "Wikipedia:Splanchnic_nerves" } ] } }, { @@ -19550,381 +66246,1845 @@ "lbl" : "thoracic nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls.", + "xrefs" : [ "MESH:A08.800.800.720.800" ] + }, + "xrefs" : [ { + "val" : "FMA:5860" + }, { + "val" : "GAID:857" + }, { + "val" : "MESH:D013900" + }, { + "val" : "SCTID:360498003" + }, { + "val" : "Wikipedia:Thoracic_nerves" + }, { + "val" : "neuronames:1725" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003727", "lbl" : "intercostal nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Intercostal_nerves" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18227" + }, { + "val" : "FMA:6028" + }, { + "val" : "GAID:858" + }, { + "val" : "MESH:D007367" + }, { + "val" : "NCIT:C32825" + }, { + "val" : "SCTID:279568001" + }, { + "val" : "Wikipedia:Intercostal_nerves" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003729", "lbl" : "mouth mucosa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucous membrane that lines the mouth.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0002860" + }, { + "val" : "CALOHA:TS-0716" + }, { + "val" : "EMAPA:26937" + }, { + "val" : "FMA:59660" + }, { + "val" : "GAID:951" + }, { + "val" : "MA:0002794" + }, { + "val" : "MESH:D009061" + }, { + "val" : "NCIT:C77637" + }, { + "val" : "Wikipedia:Oral_mucosa" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003824", "lbl" : "nerve of thoracic segment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000562" + }, { + "val" : "MESH:D013900" + }, { + "val" : "SCTID:359876006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003825", "lbl" : "nerve of abdominal segment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000528" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003827", "lbl" : "thoracic segment bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000559" + }, { + "val" : "SCTID:426649006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003828", "lbl" : "abdominal segment bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000525" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003830", "lbl" : "thoracic segment muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000561" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003831", "lbl" : "respiratory system muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35733" + }, { + "val" : "MA:0001828" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003832", "lbl" : "esophagus muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26983" + }, { + "val" : "MA:0002682" + }, { + "val" : "SCTID:360961009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003833", "lbl" : "abdominal segment muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000527" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003834", "lbl" : "thoracic segment blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000558" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003835", "lbl" : "abdominal segment blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000524" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003836", "lbl" : "abdominal segment skin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skin of body that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:264898" + }, { + "val" : "MA:0000530" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003837", "lbl" : "thoracic segment connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000560" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003838", "lbl" : "abdominal segment connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000526" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003842", "lbl" : "neural tube lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that surrounded_by a neural tube.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0011073" + }, { + "val" : "EHDAA2:0001269" + }, { + "val" : "EHDAA:2889" + }, { + "val" : "EHDAA:914" + }, { + "val" : "EMAPA:16167" + }, { + "val" : "VHOG:0001119" + }, { + "val" : "XAO:0000252" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003848", "lbl" : "gonadal vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted].", + "xrefs" : [ "Wikipedia:Gonadal_vein" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000719" + }, { + "val" : "EHDAA:8703" + }, { + "val" : "SCTID:278192008" + }, { + "val" : "VHOG:0001340" + }, { + "val" : "Wikipedia:Gonadal_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003849", "lbl" : "mesencephalic neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural crest that has_potential_to_developmentally_contribute_to a midbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003591" + }, { + "val" : "EHDAA2:0001101" + }, { + "val" : "EHDAA:360" + }, { + "val" : "TAO:0000935" + }, { + "val" : "VHOG:0000796" + }, { + "val" : "ZFA:0000935" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003852", "lbl" : "rhombencephalon neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001628" + }, { + "val" : "EHDAA:362" + }, { + "val" : "EMAPA:35747" + }, { + "val" : "TAO:0007063" + }, { + "val" : "VHOG:0001210" + }, { + "val" : "ZFA:0007063" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003853", "lbl" : "spinal cord neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural crest that has_potential_to_developmentally_contribute_to a spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:696" + }, { + "val" : "EMAPA:16163" + }, { + "val" : "EMAPA:16881" + }, { + "val" : "VHOG:0001006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003854", "lbl" : "spinal cord neural plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural plate that develops_from a future spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:312957" + }, { + "val" : "TAO:0007021" + }, { + "val" : "VHOG:0000439" + }, { + "val" : "ZFA:0007021" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003855", "lbl" : "gonad mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing gonad [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:5012" + }, { + "val" : "EMAPA:16858" + }, { + "val" : "EMAPA:17385" + }, { + "val" : "VHOG:0001090" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003869", "lbl" : "presumptive ganglion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A presumptive structure that has the potential to develop into a ganglion.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003886", "lbl" : "future coelemic cavity lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that has the potential to develop into a coelemic cavity lumen.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003887", "lbl" : "intraembryonic coelom", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.", + "xrefs" : [ "MGI:anna", "MP:0012187" ] + }, + "xrefs" : [ { + "val" : "EHDAA:251" + }, { + "val" : "EMAPA:16088" + }, { + "val" : "NCIT:C34195" + }, { + "val" : "VHOG:0000316" + }, { + "val" : "Wikipedia:Intraembryonic_coelom" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003891", "lbl" : "stroma", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:81494" + }, { + "val" : "NCIT:C67387" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "lbl" : "liver primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum.", + "xrefs" : [ "ISBN:3211492755" ] + }, + "xrefs" : [ { + "val" : "AAO:0011058" + }, { + "val" : "BTO:0003391" + }, { + "val" : "EFO:0002577" + }, { + "val" : "EFO:0003428" + }, { + "val" : "EHDAA2:0000744" + }, { + "val" : "EHDAA:973" + }, { + "val" : "EMAPA:16847" + }, { + "val" : "NCIT:C34277" + }, { + "val" : "TAO:0000124" + }, { + "val" : "XAO:0003266" + }, { + "val" : "ZFA:0000124" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003898", "lbl" : "skeletal muscle tissue of trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue in the trunk.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "SCTID:244848007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003902", "lbl" : "retinal neural layer", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the retina that contains neurons and photoreceptor cells[GO].", + "xrefs" : [ "GO:0003407" ] + }, + "xrefs" : [ { + "val" : "AAO:0011095" + }, { + "val" : "BTO:0000929" + }, { + "val" : "CALOHA:TS-0685" + }, { + "val" : "EHDAA2:0001253" + }, { + "val" : "EHDAA:4763" + }, { + "val" : "EMAPA:17171" + }, { + "val" : "EMAPA:18590" + }, { + "val" : "FMA:58628" + }, { + "val" : "MA:0000277" + }, { + "val" : "NCIT:C33166" + }, { + "val" : "TAO:0000046" + }, { + "val" : "VHOG:0000535" + }, { + "val" : "XAO:0003216" + }, { + "val" : "ZFA:0000046" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003909", "lbl" : "sinusoid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP].", + "xrefs" : [ "Wikipedia:Sinusoid_(blood_vessel)" ] + }, + "xrefs" : [ { + "val" : "FMA:63131" + }, { + "val" : "SCTID:340163004" + }, { + "val" : "TAO:0005261" + }, { + "val" : "Wikipedia:Sinusoid_(blood_vessel)" + }, { + "val" : "ZFA:0005261" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003914", "lbl" : "epithelial tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.", + "xrefs" : [ "GO:0060562", "PMID:12526790" ] + }, + "xrefs" : [ { + "val" : "AEO:0000114" + }, { + "val" : "EHDAA2:0003114" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003915", "lbl" : "endothelial tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any endothelium that has the quality of being cylindrical [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003920", "lbl" : "venous blood vessel", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A blood vessel that carries blood from the capillaries toward the heart.", + "xrefs" : [ "http://www.thefreedictionary.com/venous+blood+vessel" ] + }, + "comments" : [ "Compare to: vein" ], + "xrefs" : [ { + "val" : "EMAPA:35932" + }, { + "val" : "FMA:86188" + }, { + "val" : "MA:0000066" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "lbl" : "pancreas primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Embryonic structure that develops into pancreatic bud.", + "xrefs" : [ "Wikipedia:Pancreas#Embryological_development" ] + }, + "xrefs" : [ { + "val" : "EFO:0002579" + }, { + "val" : "EFO:0003434" + }, { + "val" : "EHDAA2:0001382" + }, { + "val" : "EHDAA:2163" + }, { + "val" : "EMAPA:17066" + }, { + "val" : "FMA:79792" + }, { + "val" : "TAO:0000254" + }, { + "val" : "XAO:0001101" + }, { + "val" : "ZFA:0000254" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "lbl" : "pancreatic epithelial bud", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID].", + "xrefs" : [ "PMID:16417468", "Wikipedia:Pancreatic_bud" ] + }, + "xrefs" : [ { + "val" : "EFO:0003470" + }, { + "val" : "EMAPA:35645" + }, { + "val" : "NCIT:C34242" + }, { + "val" : "SCTID:360398004" + }, { + "val" : "TAO:0001390" + }, { + "val" : "Wikipedia:Pancreatic_bud" + }, { + "val" : "ZFA:0001390" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003923", + "lbl" : "dorsal pancreatic bud", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Pancreatic bud that gives rise to the accessory pancreatic duct.", + "xrefs" : [ "Wikipedia:Pancreatic_bud" ] + }, + "xrefs" : [ { + "val" : "AAO:0011031" + }, { + "val" : "EFO:0003465" + }, { + "val" : "EHDAA2:0001385" + }, { + "val" : "EMAPA:17067" + }, { + "val" : "SCTID:361435005" + }, { + "val" : "TAO:0001370" + }, { + "val" : "VHOG:0001428" + }, { + "val" : "Wikipedia:Pancreatic_bud" + }, { + "val" : "XAO:0000467" + }, { + "val" : "ZFA:0001370" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0003924", + "lbl" : "ventral pancreatic bud", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Pancreatic bud that gives rise to the major pancreatic duct.", + "xrefs" : [ "Wikipedia:Pancreatic_bud" ] + }, + "xrefs" : [ { + "val" : "AAO:0011111" + }, { + "val" : "EFO:0003464" + }, { + "val" : "EHDAA2:0001389" + }, { + "val" : "EMAPA:17256" + }, { + "val" : "SCTID:361437002" + }, { + "val" : "TAO:0001369" + }, { + "val" : "VHOG:0001429" + }, { + "val" : "Wikipedia:Pancreatic_bud" + }, { + "val" : "XAO:0001103" + }, { + "val" : "ZFA:0001369" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003928", "lbl" : "digestive system duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A duct that is part of a digestive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005162" + }, { + "val" : "ZFA:0005162" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003929", "lbl" : "digestive tract epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that lines the lumen of the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000956" + }, { + "val" : "EHDAA2:0004567" + }, { + "val" : "EMAPA:32928" + }, { + "val" : "MA:0003201" + }, { + "val" : "NCIT:C12963" + }, { + "val" : "TAO:0005123" + }, { + "val" : "XAO:0003200" + }, { + "val" : "ZFA:0005123" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003932", "lbl" : "cartilage element of chondrocranium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage element of chondrocranium. Example: neurocranial trabecula.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EFO:0003690" + }, { + "val" : "TAO:0001461" + }, { + "val" : "ZFA:0001461" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003933", "lbl" : "cranial cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage element that is part of the cranial skeleton.", + "xrefs" : [ "ZFA:0001458", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001458" + }, { + "val" : "ZFA:0001458" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003937", "lbl" : "reproductive gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction.", + "xrefs" : [ "MP:0000653" ] + }, + "xrefs" : [ { + "val" : "MA:0001751" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003942", "lbl" : "somatosensory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sensory system for the sense of touch and pain.", + "xrefs" : [ "NLXANAT:090818" ] + }, + "xrefs" : [ { + "val" : "NLXANAT:090818" + }, { + "val" : "Wikipedia:Somatosensory_system" + }, { + "val" : "neuronames:2887" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003952", "lbl" : "anterior stroma of cornea", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "The anterior segment of the lamellated connective tissue layer of the cornea.", + "xrefs" : [ "MP:0003093" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003953", "lbl" : "posterior stroma of cornea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The posterior segment of the lamellated connective tissue layer of the cornea.", + "xrefs" : [ "MP:0003094" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003967", "lbl" : "cutaneous elastic tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity.", + "xrefs" : [ "MP:0008418" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0003975", "lbl" : "internal female genitalia", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina.", + "xrefs" : [ "MP:0009209" ] + }, + "comments" : [ "TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547" ], + "xrefs" : [ { + "val" : "BTO:0003099" + }, { + "val" : "FMA:45654" + }, { + "val" : "SCTID:303518005" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004015", "lbl" : "embryonic-extraembryonic boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connection between the embryo proper and extraembryonic tissues.", + "xrefs" : [ "MP:0003890" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004016", "lbl" : "dermatome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells.", + "xrefs" : [ "AEO:0001017", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AAO:0011028" + }, { + "val" : "AEO:0001017" + }, { + "val" : "EHDAA2_RETIRED:0003428" + }, { + "val" : "EHDAA:1719" + }, { + "val" : "EHDAA:1725" + }, { + "val" : "EHDAA:1731" + }, { + "val" : "EHDAA:1737" + }, { + "val" : "EMAPA:32838" + }, { + "val" : "FMA:295656" + }, { + "val" : "NCIT:C61572" + }, { + "val" : "Wikipedia:Dermatome_(embryology)" + }, { + "val" : "XAO:0000220" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004022", "lbl" : "germinal neuroepithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells.", + "xrefs" : [ "MP:0004261", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "lbl" : "biliary ductule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP].", + "xrefs" : [ "BTO:0002840", "MP:0009494" ] + }, + "xrefs" : [ { + "val" : "BTO:0002840" + }, { + "val" : "TAO:0005164" + }, { + "val" : "ZFA:0005164" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004060", "lbl" : "neural tube ventricular layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium.", + "xrefs" : [ "MP:0009689", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17152" + }, { + "val" : "EMAPA:35362" + }, { + "val" : "EMAPA_RETIRED:16783" + }, { + "val" : "MA:0003193" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004061", "lbl" : "neural tube mantle layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer.", + "xrefs" : [ "MP:0009690", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17148" + }, { + "val" : "EMAPA:35360" + }, { + "val" : "neuronames:1367" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004062", "lbl" : "neural tube marginal layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter.", + "xrefs" : [ "MP:0009691", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17151" + }, { + "val" : "neuronames:1368" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004064", "lbl" : "neural tube basal plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons.", + "xrefs" : [ "MP:0009693", "Wikipedia:Basal_plate_(neural_tube)", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + }, + "xrefs" : [ { + "val" : "AAO:0010561" + }, { + "val" : "EFO:0001904" + }, { + "val" : "NCIT:C34111" + }, { + "val" : "Wikipedia:Basal_plate_(neural_tube)" + }, { + "val" : "neuronames:1372" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004066", + "lbl" : "frontonasal prominence", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout.", + "xrefs" : [ "MP:0009901" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000578" + }, { + "val" : "EHDAA:4778" + }, { + "val" : "EMAPA:16681" + }, { + "val" : "FMA:293101" + }, { + "val" : "NCIT:C34182" + }, { + "val" : "SCTID:361486000" + }, { + "val" : "VHOG:0001319" + }, { + "val" : "Wikipedia:Frontonasal_prominence" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004068", + "lbl" : "medial nasal prominence", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it.", + "xrefs" : [ "MP:0009903", "Wikipedia:Medial_nasal_prominence" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001076" + }, { + "val" : "EHDAA:4792" + }, { + "val" : "EMAPA:16808" + }, { + "val" : "FMA:295858" + }, { + "val" : "SCTID:308877001" + }, { + "val" : "VHOG:0000804" + }, { + "val" : "Wikipedia:Medial_nasal_prominence" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004087", "lbl" : "vena cava", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart.", + "xrefs" : [ "Wikipedia:Venae_cavae", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010215" + }, { + "val" : "BTO:0001438" + }, { + "val" : "EMAPA:18415" + }, { + "val" : "FMA:321896" + }, { + "val" : "GAID:547" + }, { + "val" : "MA:0000068" + }, { + "val" : "MESH:D014684" + }, { + "val" : "NCIT:C12817" + }, { + "val" : "SCTID:244405007" + }, { + "val" : "Wikipedia:Venae_cavae" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004088", "lbl" : "orbital region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:260119" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004089", + "lbl" : "midface", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The middle of the face including the nose and its associated bony structures[MW].", + "xrefs" : [ "HP:0000309", "http://www.merriam-webster.com/medical/midface" ] + }, + "xrefs" : [ { + "val" : "FMA:285406" + }, { + "val" : "MA:0001910" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004111", "lbl" : "anatomical conduit", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "definition" : { + "val" : "Any tube, opening or passage that connects two distinct anatomical spaces.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AEO:0000080" + }, { + "val" : "EHDAA2:0003080" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "FMA:242873" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "SCTID:346902003" + }, { + "val" : "Wikipedia:Foramen" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004118", "lbl" : "vasculature of iris", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a iris [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "ZFA:0005568" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004119", "lbl" : "endoderm-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops (entirely or partially) from the endoderm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004120", "lbl" : "mesoderm-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops (entirely or partially) from the mesoderm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004121", "lbl" : "ectoderm-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops (entirely or partially) from the ectoderm.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "lbl" : "genitourinary system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction.", + "xrefs" : [ "VHOG:0000286" ] + }, + "xrefs" : [ { + "val" : "AAO:0000624" + }, { + "val" : "BILA:0000122" + }, { + "val" : "BTO:0003091" + }, { + "val" : "EFO:0003864" + }, { + "val" : "EHDAA:1013" + }, { + "val" : "EMAPA:16367" + }, { + "val" : "EV:0100094" + }, { + "val" : "FMA:280610" + }, { + "val" : "GAID:362" + }, { + "val" : "MESH:D014566" + }, { + "val" : "NCIT:C12810" + }, { + "val" : "SCTID:278861008" + }, { + "val" : "VHOG:0000286" + }, { + "val" : "XAO:0000140" + }, { + "val" : "galen:GenitoUrinarySystem" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004123", + "lbl" : "myocardial layer", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the layers of the myocardium. Example: compact layer, trabecular layer.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000080" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004124", + "lbl" : "myocardium trabecular layer", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA].", + "xrefs" : [ "ZFA:0005059" ] + }, + "xrefs" : [ { + "val" : "EFO:0003706" + }, { + "val" : "MA:0002866" + }, { + "val" : "TAO:0005059" + }, { + "val" : "ZFA:0005059" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004126", + "lbl" : "trabecular layer of ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myocardium trabecular layer that is part of a cardiac ventricle.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:83511" + }, { + "val" : "TAO:0005060" + }, { + "val" : "ZFA:0005060" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004128", "lbl" : "optic vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA].", + "xrefs" : [ "GO:0003404", "Wikipedia:Optic_vesicles" ] + }, + "comments" : [ "Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 \"Developmental Biology\"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288]" ], + "xrefs" : [ { + "val" : "AAO:0011039" + }, { + "val" : "EHDAA2:0001320" + }, { + "val" : "EMAPA:16540" + }, { + "val" : "FMA:293357" + }, { + "val" : "NCIT:C34236" + }, { + "val" : "SCTID:362864008" + }, { + "val" : "TAO:0000050" + }, { + "val" : "VHOG:0000165" + }, { + "val" : "Wikipedia:Optic_vesicles" + }, { + "val" : "XAO:0000228" + }, { + "val" : "ZFA:0000050" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004133", "lbl" : "salivatory nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Missing definition for term UBERON:0004133. Please replace it using linked reference.", + "xrefs" : [ "GO:0021751" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004139", "lbl" : "cardiogenic plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first recognizable structure derived from the heart field.", + "xrefs" : [ "GO:0003142" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000215" + }, { + "val" : "EMAPA:16106" + }, { + "val" : "VHOG:0000975" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004140", "lbl" : "primary heart field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.", + "xrefs" : [ "GO:0003138", "GOC:mtg_heart", "GOC:rl" ] + }, + "xrefs" : [ { + "val" : "XAO:0004185" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004141", "lbl" : "heart tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial tube that will give rise to the mature heart.", + "xrefs" : [ "GO:0003143", "GOC:mtg_heart" ] + }, + "xrefs" : [ { + "val" : "AAO:0010411" + }, { + "val" : "EFO:0003526" + }, { + "val" : "EMAPA:32685" + }, { + "val" : "NCIT:C34161" + }, { + "val" : "TAO:0000360" + }, { + "val" : "XAO:0000337" + }, { + "val" : "ZFA:0000360" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004142", "lbl" : "outflow tract septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outflow tract septum is a partition in the outflow tract.", + "xrefs" : [ "GO:0003148" ] + }, + "xrefs" : [ { + "val" : "XAO:0004141" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004145", "lbl" : "outflow tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outflow tract is the portion of the heart through which blood flows into the arteries.", + "xrefs" : [ "GO:0003151" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001351" + }, { + "val" : "EHDAA:464" + }, { + "val" : "EHDAA:798" + }, { + "val" : "EMAPA:16346" + }, { + "val" : "MA:0000100" + }, { + "val" : "VHOG:0000670" + }, { + "val" : "XAO:0004139" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004146", "lbl" : "His-Purkinje system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.", + "xrefs" : [ "GO:0003164", "https://github.com/geneontology/go-ontology/issues/12451" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004148", "lbl" : "cardiac vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vein of heart that drains the myocardium.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004507" + }, { + "val" : "FMA:12846" + }, { + "val" : "NCIT:C12878" + }, { + "val" : "NCIT:C12882" + }, { + "val" : "SCTID:277726009" + }, { + "val" : "Wikipedia:Coronary_circulation" + }, { + "val" : "ZFA:0005814" + }, { + "val" : "galen:CoronaryVein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004151", "lbl" : "cardiac chamber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiac chamber surrounds an enclosed cavity within the heart.", + "xrefs" : [ "GO:0003205" ] + }, + "comments" : [ "generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus" ], + "xrefs" : [ { + "val" : "FMA:7095" + }, { + "val" : "SCTID:276456008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004160", "lbl" : "proepicardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium.", + "xrefs" : [ "GO:0003342", "http://en.wiktionary.org/wiki/proepicardium" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36025" + }, { + "val" : "ZFA:0005808" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004161", "lbl" : "septum transversum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG].", + "xrefs" : [ "VHOG:0000019", "Wikipedia:Septum_transversum" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001829" + }, { + "val" : "EHDAA:736" + }, { + "val" : "EMAPA:16318" + }, { + "val" : "FMA:295593" + }, { + "val" : "NCIT:C34296" + }, { + "val" : "SCTID:308819008" + }, { + "val" : "VHOG:0000019" + }, { + "val" : "Wikipedia:Septum_transversum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004175", "lbl" : "internal genitalia", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.", + "xrefs" : [ "GO:0035260" ] + }, + "comments" : [ "TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547" ], + "xrefs" : [ { + "val" : "FMA:45652" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004176", "lbl" : "external genitalia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The external genitalia are the outer sex organs, such as the penis or vulva in mammals.", + "xrefs" : [ "GO:0035261" ] + }, + "comments" : [ "TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547" ], + "xrefs" : [ { + "val" : "FMA:45643" + }, { + "val" : "SCTID:362207005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004177", "lbl" : "hemopoietic organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ that is part of the hematopoietic system.", + "xrefs" : [ "GOC:Obol" ] + }, + "xrefs" : [ { + "val" : "BTO:0004605" + }, { + "val" : "FMA:7143" + }, { + "val" : "MA:0000747" + }, { + "val" : "SCTID:361338006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004178", "lbl" : "aorta smooth muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The nonstriated, involuntary muscle tissue located in the wall of the aorta.", + "xrefs" : [ "MGI:csmith", "MP:0009865" ] + }, + "xrefs" : [ { + "val" : "BTO:0001685" + }, { + "val" : "CALOHA:TS-0048" + }, { + "val" : "EFO:0002775" + }, { + "val" : "EMAPA:35135" + }, { + "val" : "MA:0000702" + }, { + "val" : "NCIT:C49191" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004185", "lbl" : "endodermal part of digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portions of the gut that is derived from endoderm.", + "xrefs" : [ "GO:0061031" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32930" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004215", "lbl" : "back nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000497" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004220", + "lbl" : "large intestine smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35469" + }, { + "val" : "MA:0001547" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "lbl" : "intestine smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000643" + }, { + "val" : "EMAPA:35441" + }, { + "val" : "EMAPA:35443" + }, { + "val" : "MA:0001539" + }, { + "val" : "NCIT:C49243" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004222", "lbl" : "stomach smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001818" + }, { + "val" : "EMAPA:35823" + }, { + "val" : "MA:0001627" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004225", "lbl" : "respiratory system smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0001660" + }, { + "val" : "EMAPA:35734" + }, { + "val" : "MA:0001830" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004226", "lbl" : "gastrointestinal system smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35117" + }, { + "val" : "MA:0001523" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004231", + "lbl" : "anal region smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001532" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004233", "lbl" : "lower respiratory tract smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35520" + }, { + "val" : "MA:0002410" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004234", "lbl" : "iris smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a iris [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000655" + }, { + "val" : "EMAPA:35448" + }, { + "val" : "FMA:312338" + }, { + "val" : "MA:0001270" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004236", "lbl" : "arteriole smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36287" + }, { + "val" : "FMA:312251" + }, { + "val" : "MA:0000706" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004237", "lbl" : "blood vessel smooth muscle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Smooth muscle found within, and composing the majority of the wall of blood vessels.", + "xrefs" : [ "Wikipedia:Vascular_smooth_muscle" ] + }, + "xrefs" : [ { + "val" : "BTO:0001431" + }, { + "val" : "CALOHA:TS-1107" + }, { + "val" : "EMAPA:35177" + }, { + "val" : "MA:0000710" + }, { + "val" : "MESH:D009131" + }, { + "val" : "NCIT:C33853" + }, { + "val" : "TAO:0005321" + }, { + "val" : "Wikipedia:Vascular_smooth_muscle" + }, { + "val" : "ZFA:0005321" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004238", + "lbl" : "spleen smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35807" + }, { + "val" : "MA:0000757" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004239", + "lbl" : "small intestine smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35783" + }, { + "val" : "MA:0001559" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004240", + "lbl" : "gallbladder smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35373" + }, { + "val" : "MA:0001635" + }, { + "val" : "NCIT:C49483" } ] } }, { @@ -19932,181 +68092,756 @@ "lbl" : "bronchus smooth muscle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004401" + }, { + "val" : "EMAPA:35195" + }, { + "val" : "MA:0001840" + }, { + "val" : "NCIT:C49213" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004246", "lbl" : "outflow tract smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000492" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004247", "lbl" : "bone of dorsum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of the dorsal region of an animal.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000494" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004253", "lbl" : "skin muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a skin of body [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18187" + }, { + "val" : "EMAPA:35776" + }, { + "val" : "MA:0002710" + }, { + "val" : "MA:0003139" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004258", "lbl" : "back blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000493" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004265", "lbl" : "outflow tract myocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myocardium that is part of a outflow tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001358" + }, { + "val" : "EMAPA:35623" + }, { + "val" : "MA:0000489" + }, { + "val" : "VHOG:0000603" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004267", "lbl" : "back connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of connective tissue that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000495" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004271", "lbl" : "outflow tract pericardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pericardium that is part of a outflow tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000491" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004277", "lbl" : "eye muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle that is part of the eye region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000156" + }, { + "val" : "EMAPA:35335" + }, { + "val" : "MA:0000271" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004288", "lbl" : "skeleton", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.", + "xrefs" : [ "VSAO:0000026" ] + }, + "xrefs" : [ { + "val" : "AEO:0000168" + }, { + "val" : "EHDAA2:0001843" + }, { + "val" : "EHDAA:5047" + }, { + "val" : "EMAPA:17213" + }, { + "val" : "FMA:23875" + }, { + "val" : "GAID:177" + }, { + "val" : "MA:0003006" + }, { + "val" : "MAT:0000032" + }, { + "val" : "MESH:D012863" + }, { + "val" : "MIAA:0000032" + }, { + "val" : "SCTID:361378004" + }, { + "val" : "VSAO:0000026" + }, { + "val" : "Wikipedia:Skeleton" + }, { + "val" : "XAO:0004053" + }, { + "val" : "galen:Skeleton" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004290", "lbl" : "dermomyotome", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The bilaminar epithelium formed from the myotome and dermatome.", + "xrefs" : [ "AEO:0000214" ] + }, + "xrefs" : [ { + "val" : "AAO:0010572" + }, { + "val" : "AEO:0000214" + }, { + "val" : "EHDAA2:0003259" + }, { + "val" : "EMAPA:31109" + }, { + "val" : "FMA:295654" + }, { + "val" : "NCIT:C34140" + }, { + "val" : "TAO:0001513" + }, { + "val" : "VHOG:0000676" + }, { + "val" : "ZFA:0001513" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004291", "lbl" : "heart rudiment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.", + "xrefs" : [ "GO:0003313" ] + }, + "xrefs" : [ { + "val" : "TAO:0000115" + }, { + "val" : "ZFA:0000115" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004292", "lbl" : "cardiac skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart.", + "xrefs" : [ "GO:0003204", "Wikipedia:Cardiac_skeleton" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36645" + }, { + "val" : "FMA:9496" + }, { + "val" : "Wikipedia:Cardiac_skeleton" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004297", "lbl" : "respiratory system blood vessel smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001806" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004345", "lbl" : "trophectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition.", + "xrefs" : [ "MP:0005028" ] + }, + "xrefs" : [ { + "val" : "BTO:0001840" + }, { + "val" : "EHDAA2:0002091" + }, { + "val" : "EHDAA:56" + }, { + "val" : "EMAPA:16046" + }, { + "val" : "VHOG:0000979" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004348", "lbl" : "optic eminence", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic structure that gives rise to the corneal ectoderm.", + "xrefs" : [ "MP:0006305" ] + }, + "xrefs" : [ { + "val" : "EHDAA:938" + }, { + "val" : "EMAPA:16322" + }, { + "val" : "RETIRED_EHDAA2:0001308" + }, { + "val" : "VHOG:0001296" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004356", "lbl" : "apical ectodermal ridge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP].", + "xrefs" : [ "MP:0001676", "Wikipedia:Apical_ectodermal_ridge" ] + }, + "xrefs" : [ { + "val" : "AAO:0010760" + }, { + "val" : "EMAPA:32744" + }, { + "val" : "NCIT:C34109" + }, { + "val" : "TAO:0002146" + }, { + "val" : "Wikipedia:Apical_ectodermal_ridge" + }, { + "val" : "XAO:0004121" + }, { + "val" : "ZFA:0001702" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004357", "lbl" : "paired limb/fin bud", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP].", + "xrefs" : [ "ISBN:9780878932504", "MP:0005650", "https://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056]" ], + "xrefs" : [ { + "val" : "VHOG:0001258" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004362", "lbl" : "pharyngeal arch 1", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010364" + }, { + "val" : "CALOHA:TS-2089" + }, { + "val" : "EHDAA2:0000006" + }, { + "val" : "EHDAA:573" + }, { + "val" : "EMAPA:16118" + }, { + "val" : "FMA:293019" + }, { + "val" : "MFMO:0000095" + }, { + "val" : "NCIT:C34175" + }, { + "val" : "SCTID:308767008" + }, { + "val" : "TAO:0001595" + }, { + "val" : "VHOG:0000296" + }, { + "val" : "Wikipedia:First_pharyngeal_arch" + }, { + "val" : "XAO:0000097" + }, { + "val" : "ZFA:0001612" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004363", "lbl" : "pharyngeal arch artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP].", + "xrefs" : [ "MP:0002672" ] + }, + "xrefs" : [ { + "val" : "AAO:0010414" + }, { + "val" : "EFO:0003695" + }, { + "val" : "EHDAA2:0000186" + }, { + "val" : "EHDAA:398" + }, { + "val" : "EHDAA:7327" + }, { + "val" : "EMAPA:16684" + }, { + "val" : "NCIT:C32123" + }, { + "val" : "TAO:0005004" + }, { + "val" : "VHOG:0000122" + }, { + "val" : "Wikipedia:Aortic_arches" + }, { + "val" : "XAO:0000341" + }, { + "val" : "ZFA:0005004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004364", "lbl" : "ectoplacental cone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta.", + "xrefs" : [ "MP:0001717", "PMID:19829370" ] + }, + "xrefs" : [ { + "val" : "BTO:0001715" + }, { + "val" : "EMAPA:16059" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004365", "lbl" : "vitelline blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Blood vessel that is connected to the yolk sac.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36494" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004367", "lbl" : "Descemet's membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP].", + "xrefs" : [ "MP:0004285", "https://github.com/obophenotype/uberon/issues/15" ] + }, + "comments" : [ "The strong, resistant, thin, noncellular fourth layer of the cornea, located between the endothelium (from which it is secreted) and the stroma. (Cline et al., Dictionary of Visual Science, 4th ed)" ], + "xrefs" : [ { + "val" : "EMAPA:18804" + }, { + "val" : "FMA:58309" + }, { + "val" : "GAID:894" + }, { + "val" : "MA:0001246" + }, { + "val" : "MESH:D003886" + }, { + "val" : "NCIT:C32454" + }, { + "val" : "SCTID:281076002" + }, { + "val" : "TAO:0002157" + }, { + "val" : "Wikipedia:Descemet%27s_membrane" + }, { + "val" : "ZFA:0001686" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004370", "lbl" : "anterior limiting lamina of cornea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane.", + "xrefs" : [ "ncithesaurus:Bowman_s_Membrane" ] + }, + "xrefs" : [ { + "val" : "FMA:58273" + }, { + "val" : "MA:0001240" + }, { + "val" : "NCIT:C32226" + }, { + "val" : "SCTID:281075003" + }, { + "val" : "TAO:0002155" + }, { + "val" : "Wikipedia:Bowman%27s_membrane" + }, { + "val" : "ZFA:0001684" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004374", "lbl" : "vitelline vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vascular network that is connected to the yolk sac.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Vitelline_circulation" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004375", "lbl" : "bone of free limb or fin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of an appendage [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004451", + "lbl" : "trunk or cervical vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra.", + "xrefs" : [ "UBERONREF:0000006" ] + }, + "xrefs" : [ { + "val" : "MA:0002869" + }, { + "val" : "XAO:0003077" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004455", "lbl" : "neurula embryo", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryo at the neurula stage.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BILA:0000061" + }, { + "val" : "BTO:0001766" + }, { + "val" : "NCIT:C34229" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004456", "lbl" : "entire sense organ system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Sum of all sensory systems in an organism.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:78499" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004461", "lbl" : "skeletal musculature of head", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of skeletal muscles that is part of a head [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "This class is restricted to skeletal muscles that attach to the cranial skeleton. This seems to be consistent with FMA and EMAPA usage. Note that by definition this excludes invertebrate head musculature. It corresponds to the individual muscle organ term UBERON:0002376" ], + "xrefs" : [ { + "val" : "EMAPA:18171" + }, { + "val" : "FMA:71287" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004464", "lbl" : "musculature of thorax", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000508" + }, { + "val" : "FMA:71293" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004465", "lbl" : "musculature of neck", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a neck [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000091" + }, { + "val" : "EMAPA:36050" + }, { + "val" : "FMA:71290" + }, { + "val" : "MESH:D009334" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004468", + "lbl" : "set of muscles of vertebral column", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:33061" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004469", "lbl" : "musculature of back", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a back [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:71291" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004471", "lbl" : "musculature of pectoral girdle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000423" + }, { + "val" : "FMA:33519" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004473", "lbl" : "musculature of face", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a face.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:71288" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004479", "lbl" : "musculature of trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a trunk [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0011572" + }, { + "val" : "EFO:0003531" + }, { + "val" : "FMA:50187" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004490", "lbl" : "cardiac muscle tissue of atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7283" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004491", "lbl" : "cardiac muscle tissue of interatrial septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:84083" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004492", "lbl" : "cardiac muscle tissue of cardiac septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:226279" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004493", "lbl" : "cardiac muscle tissue of myocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:261726" + }, { + "val" : "MA:0002441" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004495", "lbl" : "skeletal muscle tissue of diaphragm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:261898" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004515", "lbl" : "smooth muscle tissue of bronchiole", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:261045" } ] } }, { @@ -20114,9 +68849,12 @@ "lbl" : "smooth muscle tissue of terminal bronchiole", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:261051" } ] } }, { @@ -20124,27 +68862,132 @@ "lbl" : "smooth muscle tissue of respiratory bronchiole", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:261055" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004518", + "lbl" : "muscle of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle that is attached to a vertebra of the vertebral column.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:22594" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004521", "lbl" : "vasculature of muscle organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a muscle organ [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:87123" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004522", "lbl" : "vasculature of musculoskeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a musculoskeletal system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:239607" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004525", + "lbl" : "cardiac muscle tissue of trabecula carnea of right ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:84429" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004526", + "lbl" : "cardiac muscle tissue of trabecula carnea of left ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:84430" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004535", "lbl" : "cardiovascular system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical system that has as its parts the heart and blood vessels.", + "xrefs" : [ "BTO:0000088" ] + }, + "xrefs" : [ { + "val" : "AAO:0011001" + }, { + "val" : "BILA:0000016" + }, { + "val" : "BTO:0000088" + }, { + "val" : "CALOHA:TS-1297" + }, { + "val" : "EFO:0000791" + }, { + "val" : "EHDAA:394" + }, { + "val" : "EMAPA:16104" + }, { + "val" : "EV:0100017" + }, { + "val" : "FMA:7161" + }, { + "val" : "GAID:467" + }, { + "val" : "MA:0000010" + }, { + "val" : "MAT:0000016" + }, { + "val" : "MESH:D002319" + }, { + "val" : "MIAA:0000016" + }, { + "val" : "NCIT:C12686" + }, { + "val" : "SCTID:278198007" + }, { + "val" : "TAO:0000010" + }, { + "val" : "VHOG:0000302" + }, { + "val" : "WikipediaCategory:Cardiovascular_system" + }, { + "val" : "XAO:0000100" + }, { + "val" : "XAO:0001010" + }, { + "val" : "ZFA:0000010" } ] } }, { @@ -20152,31 +68995,94 @@ "lbl" : "blood vasculature", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A vascular network consisting of blood vessels.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001079" + }, { + "val" : "ZFA:0001079" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004548", "lbl" : "left eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An eye that is part of a left side of organism [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:12515" + }, { + "val" : "MA:0002949" + }, { + "val" : "NCIT:C119334" + }, { + "val" : "SCTID:362503005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004549", "lbl" : "right eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An eye that is part of a right side of organism [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:12514" + }, { + "val" : "MA:0002950" + }, { + "val" : "NCIT:C119333" + }, { + "val" : "SCTID:362502000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004571", "lbl" : "systemic arterial system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart.", + "xrefs" : [ "Wikipedia:Systemic_circulation#Arteries", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:45623" + }, { + "val" : "Wikipedia:Systemic_circulation#Arteries" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004572", "lbl" : "arterial system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the cardiovascular system consisting of all arteries.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004690" + }, { + "val" : "EHDAA2:0000143" + }, { + "val" : "EHDAA:396" + }, { + "val" : "EMAPA:16201" + }, { + "val" : "EMAPA:16371" + }, { + "val" : "MA:0002719" + }, { + "val" : "SCTID:362030008" + }, { + "val" : "VHOG:0000273" } ] } }, { @@ -20184,23 +69090,73 @@ "lbl" : "systemic artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart.", + "xrefs" : [ "Wikipedia:Artery#Systemic_arteries", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:66464" + }, { + "val" : "Wikipedia:Artery#Systemic_arteries" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004581", "lbl" : "systemic venous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the venous system that drains the general body tissues[Kardong].", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Systemic_venous_system" ] + }, + "xrefs" : [ { + "val" : "FMA:45626" + }, { + "val" : "Wikipedia:Systemic_venous_system" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004582", "lbl" : "venous system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004692" + }, { + "val" : "EHDAA2:0002171" + }, { + "val" : "EHDAA:486" + }, { + "val" : "EMAPA:16240" + }, { + "val" : "MA:0002720" + }, { + "val" : "NCIT:C33858" + }, { + "val" : "SCTID:362060003" + }, { + "val" : "VHOG:0000277" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004590", + "lbl" : "sphincter muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.", + "xrefs" : [ "Wikipedia:Sphincter" ] + }, + "xrefs" : [ { + "val" : "FMA:75004" + }, { + "val" : "NCIT:C28381" + }, { + "val" : "Wikipedia:Sphincter" } ] } }, { @@ -20208,219 +69164,1106 @@ "lbl" : "blood vessel endothelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000766" + }, { + "val" : "CALOHA:TS-2155" + }, { + "val" : "EMAPA:35176" + }, { + "val" : "MA:0000709" + }, { + "val" : "NCIT:C53395" + }, { + "val" : "TAO:0005257" + }, { + "val" : "ZFA:0005257" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "lbl" : "liver lobule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0008987" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35499" + }, { + "val" : "FMA:14471" + }, { + "val" : "MA:0002494" + }, { + "val" : "NCIT:C32732" + }, { + "val" : "SCTID:362194004" + }, { + "val" : "Wikipedia:Lobules_of_liver" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004663", "lbl" : "aorta wall", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of an aorta, enclosing the luminal space.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35139" + }, { + "val" : "FMA:14156" + }, { + "val" : "MA:0002901" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004664", "lbl" : "aorta tunica adventitia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0009871" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35136" + }, { + "val" : "FMA:14283" + }, { + "val" : "MA:0002902" + }, { + "val" : "SCTID:24996002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004666", "lbl" : "interventricular septum membranous part", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The membranous portion of the wall between the two lower chambers of the heart.", + "xrefs" : [ "MP:0008823" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004596" + }, { + "val" : "EMAPA:18246" + }, { + "val" : "FMA:7135" + }, { + "val" : "MA:0002939" + }, { + "val" : "SCTID:278228007" + }, { + "val" : "VHOG:0000927" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004667", "lbl" : "interventricular septum muscular part", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The muscular portion of the wall between the two lower chambers of the heart.", + "xrefs" : [ "Wikipedia:Interventricular_septum#Portions", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000885" + }, { + "val" : "EHDAA:2607" + }, { + "val" : "EMAPA:18247" + }, { + "val" : "FMA:7134" + }, { + "val" : "MA:0002940" + }, { + "val" : "RETIRED_EHDAA2:0000888" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004684", "lbl" : "raphe nuclei", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane.", + "xrefs" : [ "NLXANAT:20090205", "https://sourceforge.net/tracker/?func=detail&aid=3248146&group_id=36855&atid=440764" ] + }, + "comments" : [ "we treat NR obscurus, NR magnus etc as parts of the raphe nuclei. This is consistent with treatment in FMA, where the class is 'set of raphe nuclei'" ], + "xrefs" : [ { + "val" : "BAMS:RA" + }, { + "val" : "EMAPA:35721" + }, { + "val" : "FMA:84017" + }, { + "val" : "MA:0003147" + }, { + "val" : "MESH:D011903" + }, { + "val" : "NCIT:C97335" + }, { + "val" : "NLXANAT:20090205" + }, { + "val" : "TAO:0001429" + }, { + "val" : "Wikipedia:Raphe_nuclei" + }, { + "val" : "ZFA:0001429" + }, { + "val" : "neuronames:2495" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004688", "lbl" : "costo-cervical trunk", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted].", + "xrefs" : [ "Wikipedia:Costocervical_trunk" ] + }, + "xrefs" : [ { + "val" : "FMA:10636" + }, { + "val" : "MA:0001939" + }, { + "val" : "SCTID:244225009" + }, { + "val" : "Wikipedia:Costocervical_trunk" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004695", "lbl" : "arterial system smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36503" + }, { + "val" : "MA:0000704" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004696", "lbl" : "venous system smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36613" + }, { + "val" : "MA:0000715" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004698", "lbl" : "vena cava endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a vena cava [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000713" + }, { + "val" : "NCIT:C49318" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004699", "lbl" : "outflow tract endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a outflow tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000490" + }, { + "val" : "VHOG:0001524" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004700", "lbl" : "arterial system endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of an arterial system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35145" + }, { + "val" : "MA:0000703" + }, { + "val" : "NCIT:C49329" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004701", "lbl" : "venous system endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a venous system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35907" + }, { + "val" : "MA:0000714" + }, { + "val" : "NCIT:C49320" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004702", "lbl" : "respiratory system blood vessel endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel endothelium that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35732" + }, { + "val" : "MA:0001805" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004706", "lbl" : "bulbus cordis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010568" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000197" + }, { + "val" : "EHDAA:438" + }, { + "val" : "EHDAA:768" + }, { + "val" : "EMAPA:16333" + }, { + "val" : "FMA:70300" + }, { + "val" : "NCIT:C34114" + }, { + "val" : "SCTID:361525002" + }, { + "val" : "Wikipedia:Bulbus_cordis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004708", "lbl" : "paired limb/fin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An appendage that is part of an appendage girdle complex.", + "xrefs" : [ "UBERON:cjm", "https://github.com/geneontology/go-ontology/issues/9029" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000067" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004710", "lbl" : "pectoral appendage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues.", + "xrefs" : [ "VSAO:0000150-modified" ] + }, + "xrefs" : [ { + "val" : "VHOG:0001753" + }, { + "val" : "VSAO:0000125" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004711", "lbl" : "jugular vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava.", + "xrefs" : [ "Wikipedia:Jugular_vein" ] + }, + "xrefs" : [ { + "val" : "BTO:0001744" + }, { + "val" : "CALOHA:TS-0497" + }, { + "val" : "EMAPA:18638" + }, { + "val" : "GAID:536" + }, { + "val" : "MA:0002154" + }, { + "val" : "MESH:D007601" + }, { + "val" : "NCIT:C12738" + }, { + "val" : "SCTID:244403000" + }, { + "val" : "Wikipedia:Jugular_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004716", "lbl" : "conceptus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP].", + "xrefs" : [ "BTO:0003834", "Wikipedia:Conceptus" ] + }, + "xrefs" : [ { + "val" : "AEO:0000194" + }, { + "val" : "BTO:0003834" + }, { + "val" : "EHDAA2:0000001" + }, { + "val" : "EHDAA2:0003235" + }, { + "val" : "EMAPA:36040" + }, { + "val" : "NCIT:C34131" + }, { + "val" : "Wikipedia:Conceptus" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004731", "lbl" : "neuromere", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres).", + "xrefs" : [ "DOI:10.1016/j.tins.2013.06.004", "https://github.com/obophenotype/uberon/issues/318" ] + }, + "xrefs" : [ { + "val" : "NLX:147842" + }, { + "val" : "TAO:0001328" + }, { + "val" : "Wikipedia:Neuromere" + }, { + "val" : "ZFA:0001328" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004732", "lbl" : "segmental subdivision of nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres.", + "xrefs" : [ "FBbt:00005140", "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004733", "lbl" : "segmental subdivision of hindbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ subunit that is part of a hindbrain [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:61998" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004734", "lbl" : "gastrula", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organism at the gastrula stage.", + "xrefs" : [ "Wikipedia:Gastrula", "Wikipedia:Trilaminar_blastocyst" ] + }, + "xrefs" : [ { + "val" : "BILA:0000060" + }, { + "val" : "BTO:0001403" + }, { + "val" : "FMA:293108" + }, { + "val" : "GAID:1302" + }, { + "val" : "MESH:D005775" + }, { + "val" : "MIAA:0000179" + }, { + "val" : "NCIT:C34057" + }, { + "val" : "NCIT:C34058" + }, { + "val" : "Wikipedia:Gastrula" + }, { + "val" : "Wikipedia:Trilaminar_blastocyst" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004755", "lbl" : "skeletal tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000015", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/134" ] + }, + "comments" : [ "Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from" ], + "xrefs" : [ { + "val" : "MA:0003047" + }, { + "val" : "SCTID:309311006" + }, { + "val" : "VSAO:0000015" + }, { + "val" : "XAO:0004038" + }, { + "val" : "ZFA:0005619" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004756", "lbl" : "dermal skeletal element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dermis-derived entity that is made of skeletal tissue.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/206" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004760", + "lbl" : "gland of anal canal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of an anal canal [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic", "Wikipedia:Anal_gland" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27221" + }, { + "val" : "EMAPA:27233" + }, { + "val" : "EMAPA:27543" + }, { + "val" : "FMA:15720" + }, { + "val" : "FMA:15724" + }, { + "val" : "NCIT:C32068" + }, { + "val" : "SCTID:245448005" + }, { + "val" : "Wikipedia:Anal_gland" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004761", "lbl" : "cartilaginous neurocranium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP].", + "xrefs" : [ "Wikipedia:Chondrocranium" ] + }, + "xrefs" : [ { + "val" : "AAO:0000094" + }, { + "val" : "EHDAA:6031" + }, { + "val" : "FMA:76621" + }, { + "val" : "NCIT:C34121" + }, { + "val" : "SCTID:155540009" + }, { + "val" : "Wikipedia:Chondrocranium" + }, { + "val" : "XAO:0003059" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004764", "lbl" : "intramembranous bone tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].", + "xrefs" : [ "GO:0001957", "Wikipedia:Intramembranous_ossification" ] + }, + "xrefs" : [ { + "val" : "MA:0002837" + }, { + "val" : "Wikipedia:Intramembranous_ossification" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004765", "lbl" : "skeletal element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011129" + }, { + "val" : "TAO:0001890" + }, { + "val" : "VSAO:0000128" + }, { + "val" : "XAO:0004012" + }, { + "val" : "ZFA:0005494" + }, { + "val" : "galen:SkeletalStructure" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004766", + "lbl" : "cranial bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a cranium.", + "xrefs" : [ "UBERON:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:181792001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004768", + "lbl" : "bone of lower jaw", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004770", + "lbl" : "articular system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical system that consists of all the joints of the body.", + "xrefs" : [ "VSAO:0000181" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35150" + }, { + "val" : "FMA:23878" + }, { + "val" : "MA:0003007" + }, { + "val" : "SCTID:361827000" + }, { + "val" : "VSAO:0000181" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004777", + "lbl" : "respiratory system submucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001822" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004779", + "lbl" : "respiratory system lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001821" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004780", + "lbl" : "gastrointestinal system lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a gastrointestinal system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001899" + }, { + "val" : "NCIT:C49299" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004781", + "lbl" : "gallbladder lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a gallbladder [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35371" + }, { + "val" : "FMA:278594" + }, { + "val" : "MA:0001633" + }, { + "val" : "NCIT:C49228" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004782", + "lbl" : "gastrointestinal system serosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a digestive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001522" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004783", + "lbl" : "gallbladder serosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a gallbladder [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35372" + }, { + "val" : "FMA:14659" + }, { + "val" : "MA:0001634" + }, { + "val" : "SCTID:362197006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004784", + "lbl" : "heart ventricle wall", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical wall that is part of a cardiac ventricle [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:13884" + }, { + "val" : "MA:0002791" + }, { + "val" : "NCIT:C119295" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004785", + "lbl" : "respiratory system mucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The mucous membrane lining the respiratory tract.", + "xrefs" : [ "MESH:A04.760", "MGI:cwg", "MP:0002277" ] + }, + "xrefs" : [ { + "val" : "BTO:0000973" + }, { + "val" : "FMA:302092" + }, { + "val" : "GAID:304" + }, { + "val" : "MA:0001827" + }, { + "val" : "MESH:D020545" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004786", + "lbl" : "gastrointestinal system mucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a gastrointestinal system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "The gut mucosa of amphioxus has insulin-secreting cells. http://www.ncbi.nlm.nih.gov/pubmed/16417468" ], + "xrefs" : [ { + "val" : "BTO:0000546" + }, { + "val" : "BTO:0005568" + }, { + "val" : "EMAPA:36591" + }, { + "val" : "MA:0001521" + }, { + "val" : "SCTID:410433007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004790", + "lbl" : "skin mucous gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucous gland that is part of the skin.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35775" + }, { + "val" : "MA:0000148" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004792", + "lbl" : "secretion of endocrine pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A secretion that is part of a endocrine pancreas [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002517" + }, { + "val" : "NCIT:C33255" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004766", - "lbl" : "cranial bone", + "id" : "http://purl.obolibrary.org/obo/UBERON_0004793", + "lbl" : "secretion of exocrine pancreas", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A secretion that is part of a exocrine pancreas [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002518" + }, { + "val" : "NCIT:C33256" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004768", - "lbl" : "bone of lower jaw", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004770", - "lbl" : "articular system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004777", - "lbl" : "respiratory system submucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004779", - "lbl" : "respiratory system lamina propria", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004780", - "lbl" : "gastrointestinal system lamina propria", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004782", - "lbl" : "gastrointestinal system serosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004784", - "lbl" : "heart ventricle wall", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004785", - "lbl" : "respiratory system mucosa", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0004786", - "lbl" : "gastrointestinal system mucosa", - "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004794", "lbl" : "esophagus secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A secretion that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:79662" + }, { + "val" : "MA:0002514" + }, { + "val" : "NCIT:C52555" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004795", + "lbl" : "pancreas secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A secretion that is part of a pancreas [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002516" + }, { + "val" : "NCIT:C13270" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004797", "lbl" : "blood vessel layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36296" + }, { + "val" : "MA:0002854" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004802", "lbl" : "respiratory tract epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi.", + "xrefs" : [ "ISBN:0-683-40008-8", "MGI:anna", "MP:0010942" ] + }, + "xrefs" : [ { + "val" : "BTO:0000419" + }, { + "val" : "CALOHA:TS-0023" + }, { + "val" : "EMAPA:32827" + }, { + "val" : "MA:0001480" + }, { + "val" : "SCTID:321764001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004807", "lbl" : "respiratory system epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0023" + }, { + "val" : "EMAPA:32826" + }, { + "val" : "MA:0001823" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004808", "lbl" : "gastrointestinal system epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a digestive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32683" + }, { + "val" : "MA:0001520" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004815", "lbl" : "lower respiratory tract epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a lower respiratory tract [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001481" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "lbl" : "bile duct epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any epithelium that lines one of the bile ducts.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000417" + }, { + "val" : "MA:0001629" + }, { + "val" : "NCIT:C43616" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004821", "lbl" : "pulmonary alveolus epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO].", + "xrefs" : [ "BTO:0003511", "MP:0010898" ] + }, + "xrefs" : [ { + "val" : "BTO:0003511" + }, { + "val" : "EMAPA:35121" + }, { + "val" : "FMA:63915" + }, { + "val" : "MA:0001771" + }, { + "val" : "NCIT:C12867" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004822", + "lbl" : "extrahepatic bile duct epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a extrahepatic bile duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000742" + }, { + "val" : "EHDAA:3051" + }, { + "val" : "MA:0002661" + }, { + "val" : "NCIT:C43618" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004823", + "lbl" : "intrahepatic bile duct epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a intrahepatic bile duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000743" + }, { + "val" : "EHDAA:3053" + }, { + "val" : "MA:0002662" + }, { + "val" : "NCIT:C43617" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004830", "lbl" : "respiratory system skeletal muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001829" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004831", "lbl" : "esophagus skeletal muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "Most muscle tissue lining the digestive tract is smooth, but part of the externa of the esophagus is skeletal" ], + "xrefs" : [ { + "val" : "EMAPA:36523" + }, { + "val" : "MA:0001572" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004832", + "lbl" : "anal region skeletal muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001530" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004833", "lbl" : "lip skeletal muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001578" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004834", + "lbl" : "hepatic duct smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Smooth muscle tissue in all or part of a hepatic duct.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0001640" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004848", "lbl" : "respiratory system arterial endothelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelium of artery that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001801" } ] } }, { @@ -20428,782 +70271,4239 @@ "lbl" : "respiratory system venous endothelium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An endothelium of vein that is part of a respiratory system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001811" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004851", "lbl" : "aorta endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall.", + "xrefs" : [ "MGI:csmith", "MP:0009864" ] + }, + "xrefs" : [ { + "val" : "BTO:0000394" + }, { + "val" : "CALOHA:TS-0047" + }, { + "val" : "EFO:0002597" + }, { + "val" : "EMAPA:35134" + }, { + "val" : "MA:0000701" + }, { + "val" : "NCIT:C49190" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004852", "lbl" : "cardiovascular system endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of the cardiovascular system.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001853" + }, { + "val" : "EMAPA:35201" + }, { + "val" : "GAID:519" + }, { + "val" : "MA:0000717" + }, { + "val" : "MESH:D004730" + }, { + "val" : "NCIT:C13053" + }, { + "val" : "TAO:0002171" + }, { + "val" : "VHOG:0001217" + }, { + "val" : "XAO:0000356" + }, { + "val" : "ZFA:0001639" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004854", + "lbl" : "gastrointestinal system mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a digestive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001900" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004857", "lbl" : "skeletal muscle connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A connective tissue that surrounds a skeletal muscle tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002868" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004859", "lbl" : "eye gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Examples: harderian gland, accessory lacrimal gland, gland of Moll, gland of Zeis, nictitating membrane glands" ], + "xrefs" : [ { + "val" : "EMAPA:35334" + }, { + "val" : "MA:0000267" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004861", "lbl" : "right lung alveolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An alveolus that is part of a right lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35997" + }, { + "val" : "MA:0001786" + }, { + "val" : "NCIT:C49278" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004862", "lbl" : "left lung alveolus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An alveolus that is part of a left lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19182" + }, { + "val" : "MA:0001777" + }, { + "val" : "NCIT:C49251" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004864", "lbl" : "vasculature of retina", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A vasculature that is part of a retina [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:76552" + }, { + "val" : "MESH:D012171" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004867", + "lbl" : "orbital cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000343" + }, { + "val" : "FMA:84961" + }, { + "val" : "SCTID:280541000" + }, { + "val" : "Wikipedia:Orbit_(anatomy)" + }, { + "val" : "ZFA:0005558" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004872", "lbl" : "splanchnic layer of lateral plate mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP].", + "xrefs" : [ "Wikipedia:Lateral_plate_mesoderm#Division_into_layers" ] + }, + "xrefs" : [ { + "val" : "AAO:0011102" + }, { + "val" : "BILA:0000044" + }, { + "val" : "FMA:295568" + }, { + "val" : "Wikipedia:Lateral_plate_mesoderm#Division_into_layers" + }, { + "val" : "XAO:0000276" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004873", "lbl" : "splanchnopleure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP].", + "xrefs" : [ "Wikipedia:Splanchnopleure" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001903" + }, { + "val" : "EHDAA:383" + }, { + "val" : "EMAPA:16181" + }, { + "val" : "FMA:295564" + }, { + "val" : "NCIT:C34303" + }, { + "val" : "VHOG:0000558" + }, { + "val" : "Wikipedia:Splanchnopleure" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004874", "lbl" : "somatopleure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP].", + "xrefs" : [ "Wikipedia:Somatopleure" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001847" + }, { + "val" : "EHDAA:381" + }, { + "val" : "EMAPA:16180" + }, { + "val" : "FMA:295566" + }, { + "val" : "NCIT:C34301" + }, { + "val" : "VHOG:0000557" + }, { + "val" : "Wikipedia:Somatopleure" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004880", "lbl" : "chordamesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The central region of trunk mesoderm. This tissue forms the notochord.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000478" + }, { + "val" : "EFO:0003426" + }, { + "val" : "TAO:0000091" + }, { + "val" : "ZFA:0000091" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004883", "lbl" : "lung mesenchyme", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The mass of tissue made up of mesenchymal cells in the lung.", + "xrefs" : [ "GO:0060484" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32866" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004893", "lbl" : "interalveolar septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung.", + "xrefs" : [ "LG:0012625", "Wikipedia:Alveolar_septum" ] + }, + "xrefs" : [ { + "val" : "BTO:0003149" + }, { + "val" : "EMAPA:35433" + }, { + "val" : "MA:0000421" + }, { + "val" : "NCIT:C49473" + }, { + "val" : "Wikipedia:Alveolar_septum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004894", "lbl" : "alveolar wall", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A wall that contains the alveoli.", + "xrefs" : [ "LG:0012626", "MP:0010903" ] + }, + "xrefs" : [ { + "val" : "BTO:0002543" + }, { + "val" : "EMAPA:35120" + }, { + "val" : "FMA:14117" + }, { + "val" : "MA:0002568" + }, { + "val" : "NCIT:C13085" + }, { + "val" : "SCTID:361965008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004895", "lbl" : "alveolar smooth muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus.", + "xrefs" : [ "LG:0012628" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35122" + }, { + "val" : "MA:0002759" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004904", "lbl" : "neuron projection bundle connecting eye with brain", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "for the vertebrate-specific structure, see UBERON:0000941 (cranial nerve II)" ], + "xrefs" : [ { + "val" : "BTO:0000966" + }, { + "val" : "EV:0100351" + }, { + "val" : "TADS:0000232" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004905", "lbl" : "articulation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004906", "lbl" : "ectodermal part of digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of the gut that is derived from ectoderm.", + "xrefs" : [ "GO:0007439" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004907", + "lbl" : "lower digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition].", + "xrefs" : [ "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract" ] + }, + "xrefs" : [ { + "val" : "FMA:49179" + }, { + "val" : "NCIT:C33010" + }, { + "val" : "SCTID:279973004" + }, { + "val" : "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract" + }, { + "val" : "galen:LowerGastrointestinalTract" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004908", "lbl" : "upper digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum.", + "xrefs" : [ "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract" ] + }, + "xrefs" : [ { + "val" : "FMA:49177" + }, { + "val" : "NCIT:C33837" + }, { + "val" : "SCTID:181244000" + }, { + "val" : "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract" + }, { + "val" : "galen:UpperGastrointestinalTract" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004909", "lbl" : "epithelium of gonad", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium surrounding a gonad.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:4032" + }, { + "val" : "EHDAA:5931" + }, { + "val" : "NCIT:C32676" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004911", "lbl" : "epithelium of female gonad", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium surrounding an ovary.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0003661" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "lbl" : "biliary bud", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000171" + }, { + "val" : "EMAPA:16561" + }, { + "val" : "EMAPA_RETIRED:16565" + }, { + "val" : "VHOG:0001351" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004913", + "lbl" : "hepatopancreatic ampulla", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct.", + "xrefs" : [ "Wikipedia:Ampulla_of_Vater" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2348" + }, { + "val" : "FMA:15076" + }, { + "val" : "GAID:283" + }, { + "val" : "MESH:D014670" + }, { + "val" : "NCIT:C13011" + }, { + "val" : "SCTID:362200007" + }, { + "val" : "TAO:0005167" + }, { + "val" : "Wikipedia:Ampulla_of_Vater" + }, { + "val" : "ZFA:0005167" + }, { + "val" : "galen:AmpullaOfVater" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004914", + "lbl" : "duodenal papilla", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/duodenal+papilla" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18662" + }, { + "val" : "FMA:15953" + }, { + "val" : "MA:0003107" + }, { + "val" : "NCIT:C119578" + }, { + "val" : "SCTID:245389007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004915", + "lbl" : "sphincter of hepatopancreatic ampulla", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP].", + "xrefs" : [ "Wikipedia:Sphincter_of_ampulla" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18663" + }, { + "val" : "FMA:15077" + }, { + "val" : "GAID:285" + }, { + "val" : "MESH:D009803" + }, { + "val" : "NCIT:C13065" + }, { + "val" : "SCTID:181271000" + }, { + "val" : "Wikipedia:Sphincter_of_ampulla" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004916", + "lbl" : "anal sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphincter muscle that is part of a anal region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36052" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004921", "lbl" : "subdivision of digestive tract", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A proximal-distal subdivision of the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:71131" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004923", "lbl" : "organ component layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A part of a wall of an organ that forms a layer.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:82485" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004924", "lbl" : "submucosa of pharynx", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The tissue underlying the tunica mucosa of the pharynx.", + "xrefs" : [ "BTO:0002113" ] + }, + "xrefs" : [ { + "val" : "BTO:0002113" + }, { + "val" : "FMA:75144" + }, { + "val" : "SCTID:19594009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004926", + "lbl" : "submucosa of cystic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a cystic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18013" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004932", + "lbl" : "submucosa of sigmoid colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a sigmoid colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15027" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004934", + "lbl" : "submucosa of body of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a body of stomach [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:17059" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004936", + "lbl" : "submucosa of pyloric antrum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a pyloric antrum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:17060" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004937", + "lbl" : "submucosa of pylorus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a pylorus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27201" + }, { + "val" : "FMA:17462" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004938", + "lbl" : "submucosa of biliary tree", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a biliary tree [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18009" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004939", + "lbl" : "submucosa of common bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a common bile duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18011" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004940", + "lbl" : "submucosa of common hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a common hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18014" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004941", + "lbl" : "submucosa of right hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a right hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18015" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004942", + "lbl" : "submucosa of left hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a left hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:18017" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0004952", "lbl" : "submucosa of bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:62775" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004988", + "lbl" : "mucosa of cystic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a cystic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14690" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004993", + "lbl" : "mucosa of sigmoid colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a sigmoid colon [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15026" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004995", + "lbl" : "mucosa of body of stomach", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a body of stomach [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:17054" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004997", + "lbl" : "mucosa of pyloric antrum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a pyloric antrum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004107" + }, { + "val" : "FMA:17055" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004998", + "lbl" : "mucosa of pylorus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a pylorus [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004110" + }, { + "val" : "EMAPA:27199" + }, { + "val" : "FMA:17461" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0004999", + "lbl" : "mucosa of biliary tree", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a biliary tree [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14695" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005000", + "lbl" : "mucosa of common bile duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a common bile duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14688" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005001", + "lbl" : "mucosa of common hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a common hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14691" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005002", + "lbl" : "mucosa of right hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a right hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14692" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005003", + "lbl" : "mucosa of left hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a left hepatic duct [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14693" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005031", + "lbl" : "mucosa of upper lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a upper lip [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:59832" + }, { + "val" : "NCIT:C12224" + }, { + "val" : "SCTID:362088009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005032", "lbl" : "mucosa of lower lip", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a lower lip [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:59833" + }, { + "val" : "NCIT:C12225" + }, { + "val" : "SCTID:362089001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005033", + "lbl" : "mucosa of gallbladder", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a gallbladder [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14662" + }, { + "val" : "SCTID:362196002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005039", "lbl" : "mucosa of bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:62774" + }, { + "val" : "SCTID:10887006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005040", "lbl" : "mucosa of terminal bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a terminal bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:263232" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005041", "lbl" : "mucosa of respiratory bronchiole", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a respiratory bronchiole [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:263238" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005056", "lbl" : "external female genitalia", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_50557" + "definition" : { + "val" : "An external genitalia that is part of a female reproductive system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547" ], + "xrefs" : [ { + "val" : "BTO:0003100" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "val" : "EMAPA:30984" + }, { + "val" : "FMA:45649" + }, { + "val" : "SCTID:362234008" + }, { + "val" : "galen:FemaleExternalGenitalia" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005057", "lbl" : "immune organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that is part of a immune system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005058", "lbl" : "hemolymphoid system gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a hemolymphoid system [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18766" + }, { + "val" : "MA:0002962" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005061", "lbl" : "neural groove", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds.", + "xrefs" : [ "GO:0001842", "Wikipedia:Neural_groove", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0011071" + }, { + "val" : "EMAPA:35594" + }, { + "val" : "FMA:295624" + }, { + "val" : "NCIT:C34224" + }, { + "val" : "SCTID:361463007" + }, { + "val" : "Wikipedia:Neural_groove" + }, { + "val" : "XAO:0000248" + }, { + "val" : "neuronames:1363" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005062", "lbl" : "neural fold", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the two elevated edges of the neural groove[GO,MP].", + "xrefs" : [ "GO:0001842", "MP:0011256", "Wikipedia:Neural_fold" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001249" + }, { + "val" : "FMA:295618" + }, { + "val" : "NCIT:C34223" + }, { + "val" : "SCTID:361461009" + }, { + "val" : "Wikipedia:Neural_fold" + }, { + "val" : "XAO:0004087" + }, { + "val" : "neuronames:1364" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005064", + "lbl" : "left ventricular trabecular myocardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Missing definition for term UBERON:0005064. Please replace it using linked reference.", + "xrefs" : [ "GO:0003225" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005066", + "lbl" : "right ventricular trabecular myocardium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Missing definition for term UBERON:0005066. Please replace it using linked reference.", + "xrefs" : [ "GO:0003227" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005068", "lbl" : "neural rod", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN].", + "xrefs" : [ "GO:0014024", "ZFA:0000133" ] + }, + "xrefs" : [ { + "val" : "EFO:0003498" + }, { + "val" : "TAO:0000133" + }, { + "val" : "ZFA:0000133" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005076", "lbl" : "hindbrain-spinal cord boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005082", "lbl" : "tube lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hole in a tube[GO].", + "xrefs" : [ "GO:0060609" ] + }, + "xrefs" : [ { + "val" : "AEO:0000078" + }, { + "val" : "EHDAA2:0004618" + }, { + "val" : "RETIRED_EHDAA2:0003078" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005085", "lbl" : "ectodermal placode", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO].", + "xrefs" : [ "GO:0060788" ] + }, + "xrefs" : [ { + "val" : "AEO:0000218" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005090", "lbl" : "muscle structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO].", + "xrefs" : [ "GO:0061061" ] + }, + "xrefs" : [ { + "val" : "FMA:30316" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005092", "lbl" : "right horn of sinus venosus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001841" + }, { + "val" : "EHDAA:484" + }, { + "val" : "EMAPA:16239" + }, { + "val" : "FMA:70318" + }, { + "val" : "VHOG:0000489" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005153", "lbl" : "epithelial bud", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bud is a protrusion that forms from an epithelial sheet by localized folding.", + "xrefs" : [ "GO:0060572" ] + }, + "xrefs" : [ { + "val" : "BTO:0001639" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005156", "lbl" : "reproductive structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any anatomical structure that is part of the reproductive system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005157", "lbl" : "epithelial fold", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial sheet bent on a linear axis.", + "xrefs" : [ "GO:0060571" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005158", "lbl" : "parenchyma of central nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The functional tissue of the central nervous system consisting of neurons and glial cells.", + "xrefs" : [ "CL:tm", "https://github.com/obophenotype/uberon/issues/8" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005162", "lbl" : "multi cell part structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part.", + "xrefs" : [ "CARO:0001000" ] + }, + "xrefs" : [ { + "val" : "AAO:0011000" + }, { + "val" : "CARO:0001000" + }, { + "val" : "FMA:83115" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005169", "lbl" : "interstitial tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Connective tissue between the cellular elements of a structure.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/tissue" ] + }, + "xrefs" : [ { + "val" : "FMA:86301" + }, { + "val" : "SCTID:85293002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005171", + "lbl" : "hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000741" + }, { + "val" : "EHDAA:3049" + }, { + "val" : "EMAPA:16843" + }, { + "val" : "FMA:71891" + }, { + "val" : "MA:0000357" + }, { + "val" : "NCIT:C32730" + }, { + "val" : "SCTID:245399002" + }, { + "val" : "VHOG:0000219" + }, { + "val" : "galen:HepaticDuct" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005172", "lbl" : "abdomen element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000522" + }, { + "val" : "SCTID:272631008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005173", "lbl" : "abdominal segment element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000529" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005174", "lbl" : "dorsal region element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0001901" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005177", "lbl" : "trunk region element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000516" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005178", "lbl" : "thoracic cavity element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000557" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005181", "lbl" : "thoracic segment organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0000563" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005194", "lbl" : "thoracic vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a thorax [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002235" + }, { + "val" : "NCIT:C53142" + }, { + "val" : "SCTID:281472008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005203", + "lbl" : "trachea gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen.", + "xrefs" : [ "ISBN:1451113412", "MGI:Anna", "PMID:15973734", "http://medical-dictionary.thefreedictionary.com/tracheal+glands", "https://github.com/obophenotype/uberon/issues/1197" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36574" + }, { + "val" : "FMA:7473" + }, { + "val" : "MA:0002937" + }, { + "val" : "SCTID:197423006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005221", + "lbl" : "liver right lobe parenchyma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A parenchyma that is part of a right lobe of liver [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001010" + }, { + "val" : "EMAPA:18317" + }, { + "val" : "FMA:71657" + }, { + "val" : "VHOG:0000840" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005222", + "lbl" : "liver left lobe parenchyma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A parenchyma that is part of a left lobe of liver [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001002" + }, { + "val" : "EMAPA:18310" + }, { + "val" : "FMA:71658" + }, { + "val" : "VHOG:0000839" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005233", + "lbl" : "medial-nasal process ectoderm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ectoderm that is part of a medial nasal prominence [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001078" + }, { + "val" : "EMAPA:16809" + }, { + "val" : "FMA:312675" + }, { + "val" : "VHOG:0000803" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005234", "lbl" : "optic eminence ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ectoderm that is part of a optic eminence [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:940" + }, { + "val" : "EMAPA:16539" + }, { + "val" : "RETIRED_EHDAA2:0001309" + }, { + "val" : "VHOG:0001105" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005239", "lbl" : "basal plate metencephalon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001154" + }, { + "val" : "EMAPA:17078" + }, { + "val" : "VHOG:0000320" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005243", "lbl" : "interventricular septum endocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endocardium that is part of a interventricular septum [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000886" + }, { + "val" : "EHDAA2:0000887" + }, { + "val" : "FMA:83584" + }, { + "val" : "VHOG:0000615" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005248", "lbl" : "bulbus cordis myocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A myocardium that is part of a bulbus cordis [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36488" + }, { + "val" : "VHOG:0000609" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005250", "lbl" : "stomatodeum gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a stomodeum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "VHOG:0000658" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005251", "lbl" : "yolk sac cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that is part of a yolk sac [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16055" + }, { + "val" : "FMA:63942" + }, { + "val" : "VHOG:0000843" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005253", "lbl" : "head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells.", + "xrefs" : [ "ISBN:0683400088", "MP:0011260" ] + }, + "xrefs" : [ { + "val" : "EFO:0003492" + }, { + "val" : "EHDAA2:0000732" + }, { + "val" : "EHDAA:179" + }, { + "val" : "EMAPA:16098" + }, { + "val" : "EMAPA_RETIRED:16269" + }, { + "val" : "FMA:76622" + }, { + "val" : "TAO:0000113" + }, { + "val" : "VHOG:0000332" + }, { + "val" : "ZFA:0000113" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005256", "lbl" : "trunk mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing trunk.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003485" + }, { + "val" : "EHDAA2:0002092" + }, { + "val" : "EHDAA:377" + }, { + "val" : "EMAPA:16177" + }, { + "val" : "TAO:0000081" + }, { + "val" : "VHOG:0000281" + }, { + "val" : "ZFA:0000081" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005290", "lbl" : "myelencephalon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP].", + "xrefs" : [ "BTO:0000758", "Wikipedia:Myelencephalon" ] + }, + "xrefs" : [ { + "val" : "BTO:0000758" + }, { + "val" : "CALOHA:TS-0607" + }, { + "val" : "CALOHA:TS-2365" + }, { + "val" : "DHBA:10662" + }, { + "val" : "EHDAA2:0001207" + }, { + "val" : "EHDAA:5526" + }, { + "val" : "EMAPA:17082" + }, { + "val" : "HBA:9512" + }, { + "val" : "MA:0000205" + }, { + "val" : "VHOG:0000456" + }, { + "val" : "Wikipedia:Myelencephalon" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005291", "lbl" : "embryonic tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of tissue that is part of an embryo.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2100" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005292", "lbl" : "extraembryonic tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0003360" + }, { + "val" : "CALOHA:TS-2119" + }, { + "val" : "EFO:0001406" + }, { + "val" : "MAT:0000061" + }, { + "val" : "MIAA:0000061" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005316", "lbl" : "endocardial endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The endothelial lining of the endocardium.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:83596" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005317", "lbl" : "pulmonary artery endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO].", + "xrefs" : [ "GO:0061155" ] + }, + "xrefs" : [ { + "val" : "BTO:0000137" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005334", "lbl" : "oral lamina propria", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a mucosa of oral region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26947" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005337", "lbl" : "outflow tract of ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP].", + "xrefs" : [ "Wikipedia:Ventricular_outflow_tract" ] + }, + "xrefs" : [ { + "val" : "FMA:13225" + }, { + "val" : "Wikipedia:Ventricular_outflow_tract" + }, { + "val" : "XAO:0004140" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005338", "lbl" : "outflow tract aortic component", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An outflow tract that is part of a aorta.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001353" + }, { + "val" : "EMAPA:17329" + }, { + "val" : "MA:0000101" + }, { + "val" : "VHOG:0001394" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005339", "lbl" : "outflow tract pulmonary component", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001359" + }, { + "val" : "EHDAA:4401" + }, { + "val" : "EMAPA:17330" + }, { + "val" : "MA:0000102" + }, { + "val" : "VHOG:0001395" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005388", "lbl" : "photoreceptor array", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An array of photoreceptors and any supporting cells found in an eye.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005389", "lbl" : "transparent eye structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005396", "lbl" : "carotid artery segment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of: the common carotid artery, or its branches, the external and internal carotid arteries.", + "xrefs" : [ "Wikipedia:Carotid_artery", "https://sourceforge.net/tracker/?func=detail&aid=3486870&group_id=76834&atid=994764" ] + }, + "xrefs" : [ { + "val" : "AAO:0010217" + }, { + "val" : "BTO:0000168" + }, { + "val" : "CALOHA:TS-0116" + }, { + "val" : "EFO:0000818" + }, { + "val" : "EHDAA:6385" + }, { + "val" : "EMAPA:18609" + }, { + "val" : "EV:0100379" + }, { + "val" : "FMA:70504" + }, { + "val" : "GAID:478" + }, { + "val" : "MA:0001925" + }, { + "val" : "MAT:0000501" + }, { + "val" : "MESH:D002339" + }, { + "val" : "NCIT:C12687" + }, { + "val" : "SCTID:362040006" + }, { + "val" : "SCTID:69105007" + }, { + "val" : "TAO:0000097" + }, { + "val" : "VHOG:0000266" + }, { + "val" : "Wikipedia:Carotid_artery" + }, { + "val" : "ZFA:0000097" + }, { + "val" : "galen:CarotidArtery" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005398", "lbl" : "female reproductive gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sex gland that is part of a female reproductive system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000254" + }, { + "val" : "MA:0000383" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005409", "lbl" : "alimentary part of gastrointestinal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the digestive system that excludes the hepatobiliary system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0000058" + }, { + "val" : "CALOHA:TS-0407" + }, { + "val" : "EHDAA2:0000110" + }, { + "val" : "EHDAA:514" + }, { + "val" : "EMAPA:16246" + }, { + "val" : "FMA:71132" + }, { + "val" : "GAID:294" + }, { + "val" : "MA:0000323" + }, { + "val" : "MESH:D041981" + }, { + "val" : "NCIT:C12378" + }, { + "val" : "SCTID:373871007" + }, { + "val" : "VHOG:0000412" + }, { + "val" : "galen:GastrointestinalTract" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005419", "lbl" : "pectoral appendage bud", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A limb bud that develops into a forelimb or pectoral fin.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "at this time we have no need to name a more specific 'pectoral fin bud' class, but we may in future" ], + "xrefs" : [ { + "val" : "EFO:0003430" + }, { + "val" : "TAO:0000141" + }, { + "val" : "VHOG:0001754" + }, { + "val" : "VHOG_RETIRED:0001259" + }, { + "val" : "ZFA:0000141" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005421", "lbl" : "pectoral appendage apical ectodermal ridge", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An apical ectodermal ridge that is part of a pectoral appendage bud.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003487" + }, { + "val" : "EHDAA2:0000138" + }, { + "val" : "EMAPA:16778" + }, { + "val" : "TAO:0000085" + }, { + "val" : "TAO:0000736" + }, { + "val" : "VHOG:0001064" + }, { + "val" : "ZFA:0000085" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005423", "lbl" : "developing anatomical structure", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + "xrefs" : [ { + "val" : "AEO:0000125" + }, { + "val" : "CALOHA:TS-2122" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "val" : "EHDAA2:0003125" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "FMA:292313" + }, { + "val" : "MIAA:0000019" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005425", "lbl" : "presumptive neural retina", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that is the inner layer of the optic cup and will become the neural retina.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001304" + }, { + "val" : "EMAPA:16675" + }, { + "val" : "TAO:0001071" + }, { + "val" : "VHOG:0000490" + }, { + "val" : "ZFA:0001071" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005426", "lbl" : "lens vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that gives rise to the lens.", + "xrefs" : [ "ZFIN:curator", "https://sourceforge.net/tracker/?func=detail&atid=994726&aid=3514998&group_id=76834" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000983" + }, { + "val" : "EHDAA:4737" + }, { + "val" : "EMAPA:17163" + }, { + "val" : "SCTID:361510002" + }, { + "val" : "TAO:0002205" + }, { + "val" : "VHOG:0001163" + }, { + "val" : "ZFA:0001679" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005427", "lbl" : "corneal primordium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea.", + "xrefs" : [ "ZFIN:ZDB-PUB-061010-3" ] + }, + "xrefs" : [ { + "val" : "TAO:0002188" + }, { + "val" : "ZFA:0001688" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005428", "lbl" : "vagal neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA].", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002156" + }, { + "val" : "EHDAA:669" + }, { + "val" : "TAO:0000818" + }, { + "val" : "VHOG:0001208" + }, { + "val" : "XAO:0004191" + }, { + "val" : "ZFA:0000818" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005432", "lbl" : "aortic sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates.", + "xrefs" : [ "MP:0012510" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004145" + }, { + "val" : "EHDAA:9826" + }, { + "val" : "EMAPA:36461" + }, { + "val" : "FMA:71008" + }, { + "val" : "RETIRED_EHDAA2:0000133" + }, { + "val" : "SCTID:361527005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005434", "lbl" : "cervical region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:24219" + }, { + "val" : "SCTID:123958008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005436", + "lbl" : "common hepatic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:.", + "xrefs" : [ "Wikipedia:Common_hepatic_artery" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000308" + }, { + "val" : "EHDAA:8570" + }, { + "val" : "FMA:14771" + }, { + "val" : "MA:0003094" + }, { + "val" : "SCTID:244263001" + }, { + "val" : "Wikipedia:Common_hepatic_artery" + }, { + "val" : "galen:CommonHepaticArtery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "lbl" : "foramen rotundum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa.", + "xrefs" : [ "Wikipedia:Foramen_rotundum" ] + }, + "xrefs" : [ { + "val" : "AAO:0000194" + }, { + "val" : "EHDAA2:0000552" + }, { + "val" : "EHDAA:10629" + }, { + "val" : "EMAPA:18712" + }, { + "val" : "FMA:53154" + }, { + "val" : "SCTID:369439002" + }, { + "val" : "VHOG:0001543" + }, { + "val" : "Wikipedia:Foramen_rotundum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005460", "lbl" : "left vitelline vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vitelline vein that is in the left side of a multicellular organism.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000971" + }, { + "val" : "EMAPA:16380" + }, { + "val" : "EMAPA:16698" + }, { + "val" : "FMA:70307" + }, { + "val" : "SCTID:361446008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005472", "lbl" : "right vitelline vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vitelline vein that is in the right side of a multicellular organism.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001766" + }, { + "val" : "EMAPA:16381" + }, { + "val" : "EMAPA:16699" + }, { + "val" : "FMA:70306" + }, { + "val" : "SCTID:361445007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005478", "lbl" : "sulcus limitans of neural tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD].", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/Sulcus+limitans", "http://www.ncbi.nlm.nih.gov/books/NBK10047" ] + }, + "xrefs" : [ { + "val" : "BAMS:slim" + }, { + "val" : "BAMS:slm" + }, { + "val" : "neuronames:629" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005487", "lbl" : "vitelline vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The paired veins that carry blood from the yolk sac back to the embryo.", + "xrefs" : [ "MGI:csmith", "MP:0010666" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36021" + }, { + "val" : "FMA:70305" + }, { + "val" : "NCIT:C34329" + }, { + "val" : "RETIRED_EHDAA2:0002209" + }, { + "val" : "SCTID:2730004" + }, { + "val" : "SCTID:308832003" + }, { + "val" : "VHOG:0000401" + }, { + "val" : "Wikipedia:Vitelline_veins" + }, { + "val" : "XAO:0000376" + }, { + "val" : "XAO:0004147" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005496", "lbl" : "neural tube lateral wall", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue on the side of the lumen of the neural tube.", + "xrefs" : [ "ZFA:0001435" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001257" + }, { + "val" : "EHDAA:2873" + }, { + "val" : "EHDAA:912" + }, { + "val" : "EMAPA:16166" + }, { + "val" : "TAO:0001435" + }, { + "val" : "VHOG:0000513" + }, { + "val" : "ZFA:0001435" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005497", "lbl" : "non-neural ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998)." ], + "xrefs" : [ { + "val" : "EFO:0003643" + }, { + "val" : "EHDAA:257" + }, { + "val" : "EMAPA:16074" + }, { + "val" : "RETIRED_EHDAA2:0001273" + }, { + "val" : "TAO:0001178" + }, { + "val" : "VHOG:0001372" + }, { + "val" : "XAO:0004091" + }, { + "val" : "ZFA:0001178" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005498", "lbl" : "primitive heart tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that arises from the heart rudiment and will become the heart tube.", + "xrefs" : [ "ZFA:0000149" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001512" + }, { + "val" : "EHDAA:424" + }, { + "val" : "EHDAA:436" + }, { + "val" : "EMAPA:16215" + }, { + "val" : "FMA:321916" + }, { + "val" : "SCTID:361522004" + }, { + "val" : "TAO:0000149" + }, { + "val" : "Wikipedia:Primitive_heart_tube" + }, { + "val" : "ZFA:0000149" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005501", "lbl" : "rhombomere lateral wall", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural tube lateral wall that is part of a rhombomere.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32819" + }, { + "val" : "EMAPA:35364" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005563", "lbl" : "trigeminal neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cranial neural crest which gives rise to the trigeminal ganglion.", + "xrefs" : [ "ZFA:0000080" ] + }, + "xrefs" : [ { + "val" : "EFO:0003484" + }, { + "val" : "EHDAA2:0002083" + }, { + "val" : "EHDAA:667" + }, { + "val" : "EMAPA:16170" + }, { + "val" : "TAO:0000080" + }, { + "val" : "VHOG:0000269" + }, { + "val" : "ZFA:0000080" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005564", "lbl" : "gonad primordium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that gives rise to the immature gonad.", + "xrefs" : [ "ZFA:0001262" ] + }, + "xrefs" : [ { + "val" : "EFO:0003651" + }, { + "val" : "EHDAA:5927" + }, { + "val" : "EMAPA:17204" + }, { + "val" : "RETIRED_EHDAA2:0002148" + }, { + "val" : "TAO:0001262" + }, { + "val" : "WBbt:0008366" + }, { + "val" : "ZFA:0001262" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005594", "lbl" : "head somite", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Somite located in the head region, caudal to the otic vesicle.", + "xrefs" : [ "PMID:11830559" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0003437" + }, { + "val" : "EMAPA:16172" + }, { + "val" : "XAO:0000313" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005597", "lbl" : "lung primordium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum.", + "xrefs" : [ "XAO:0001002" ] + }, + "xrefs" : [ { + "val" : "AAO:0011059" + }, { + "val" : "EFO:0002578" + }, { + "val" : "EMAPA:36007" + }, { + "val" : "XAO:0001002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005598", "lbl" : "trunk somite", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A somite that is part of a trunk.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0010385" + }, { + "val" : "EHDAA2:0003438" + }, { + "val" : "EMAPA:16184" + }, { + "val" : "XAO:0000314" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005602", + "lbl" : "dorsal mesogastrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum.", + "xrefs" : [ "Wikipedia:Dorsal_mesentery" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000416" + }, { + "val" : "EHDAA:3001" + }, { + "val" : "EMAPA:17025" + }, { + "val" : "MA:0001618" + }, { + "val" : "NCIT:C34142" + }, { + "val" : "VHOG:0000352" + }, { + "val" : "Wikipedia:Dorsal_mesentery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005604", + "lbl" : "extrahepatic part of hepatic duct", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:16844" + }, { + "val" : "MA:0001636" + }, { + "val" : "VHOG:0000215" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005613", "lbl" : "left dorsal aorta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000936" + }, { + "val" : "EHDAA:404" + }, { + "val" : "EMAPA:16205" + }, { + "val" : "MA:0000478" + }, { + "val" : "SCTID:361403005" + }, { + "val" : "VHOG:0000484" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005614", "lbl" : "lens anterior epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000984" + }, { + "val" : "EHDAA:9059" + }, { + "val" : "EMAPA:17304" + }, { + "val" : "EMAPA:17839" + }, { + "val" : "FMA:70612" + }, { + "val" : "MA:0001302" + }, { + "val" : "NCIT:C33641" + }, { + "val" : "RETIRED_EHDAA2:0000976" + }, { + "val" : "SCTID:362521008" + }, { + "val" : "VHOG:0001425" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005616", + "lbl" : "mesenteric artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Arteries which arise from the abdominal aorta and distribute to most of the intestines.", + "xrefs" : [ "MESH:A07.231.114.565", "Wikipedia:Mesenteric_artery" ] + }, + "xrefs" : [ { + "val" : "BTO:0000779" + }, { + "val" : "EHDAA2:0001123" + }, { + "val" : "EHDAA:4343" + }, { + "val" : "EMAPA:17312" + }, { + "val" : "MA:0002003" + }, { + "val" : "MESH:D008638" + }, { + "val" : "NCIT:C52975" + }, { + "val" : "SCTID:281084003" + }, { + "val" : "VHOG:0001117" + }, { + "val" : "Wikipedia:Mesenteric_artery" + }, { + "val" : "XAO:0000370" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005617", + "lbl" : "mesenteric vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that returns blood from the intestines.", + "xrefs" : [ "MESH:A07.231.908.670.385", "Wikipedia:Mesenteric_vein" ] + }, + "xrefs" : [ { + "val" : "BTO:0002781" + }, { + "val" : "EHDAA:4442" + }, { + "val" : "EMAPA:17348" + }, { + "val" : "MA:0002177" + }, { + "val" : "MESH:D008642" + }, { + "val" : "NCIT:C53055" + }, { + "val" : "RETIRED_EHDAA2:0001125" + }, { + "val" : "SCTID:304045008" + }, { + "val" : "Wikipedia:Mesenteric_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005622", "lbl" : "right dorsal aorta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001720" + }, { + "val" : "EHDAA:406" + }, { + "val" : "EMAPA:16206" + }, { + "val" : "MA:0000479" + }, { + "val" : "SCTID:361404004" + }, { + "val" : "VHOG:0000485" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005631", "lbl" : "extraembryonic membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo.", + "xrefs" : [ "ISBN:0073040584" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004714" + }, { + "val" : "FMA:305915" + }, { + "val" : "SCTID:362840007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005637", + "lbl" : "pyloric region epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a pylorus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001582" + }, { + "val" : "EMAPA:17633" + }, { + "val" : "RETIRED_EHDAA2:0001927" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005638", "lbl" : "anterior chamber epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a anterior chamber of eyeball.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000130" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005656", "lbl" : "lens vesicle epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a lens vesicle.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000987" + }, { + "val" : "EMAPA:17165" + }, { + "val" : "VHOG:0000532" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005662", "lbl" : "4th arch ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ectoderm that is part of a pharyngeal arch 4.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004032" + }, { + "val" : "EMAPA:16762" + }, { + "val" : "EMAPA:16764" + }, { + "val" : "EMAPA:16768" + }, { + "val" : "RETIRED_EHDAA2:0000094" + }, { + "val" : "VHOG:0001095" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005666", "lbl" : "4th arch endoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endoderm that is part of a pharyngeal arch 4.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004033" + }, { + "val" : "EMAPA:16765" + }, { + "val" : "EMAPA:16767" + }, { + "val" : "EMAPA:16769" + }, { + "val" : "RETIRED_EHDAA2:0000095" + }, { + "val" : "VHOG:0001092" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005669", "lbl" : "peritoneal cavity mesothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelium that is part of a peritoneal cavity.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0003156" + }, { + "val" : "EHDAA2:0001447" + }, { + "val" : "EMAPA:16139" + }, { + "val" : "FMA:18147" + }, { + "val" : "SCTID:34073007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005672", "lbl" : "right lung endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a right lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001755" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005673", "lbl" : "left lung endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a left lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000961" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005685", + "lbl" : "midgut dorsal mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dorsal mesentery that is part of a midgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16722" + }, { + "val" : "EMAPA:17040" + }, { + "val" : "EMAPA:18671" + }, { + "val" : "RETIRED_EHDAA2:0001187" + }, { + "val" : "SCTID:361434009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005688", "lbl" : "lens vesicle cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that is part of a lens vesicle.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000986" + }, { + "val" : "EMAPA:17164" + }, { + "val" : "VHOG:0000531" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005691", "lbl" : "4th arch mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a pharyngeal arch 4.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000096" + }, { + "val" : "EHDAA:1677" + }, { + "val" : "EMAPA:16770" + }, { + "val" : "FMA:295702" + }, { + "val" : "VHOG:0001052" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005702", "lbl" : "optic eminence mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a optic eminence.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:942" + }, { + "val" : "EMAPA:16324" + }, { + "val" : "RETIRED_EHDAA2:0001310" + }, { + "val" : "VHOG:0001073" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "lbl" : "foregut duodenum mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery of duodenum that is part of a foregut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000564" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "lbl" : "midgut duodenum mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery of duodenum that is part of a midgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001193" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005720", "lbl" : "hindbrain venous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A venous system that is part of a hindbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000776" + }, { + "val" : "EMAPA:18632" + }, { + "val" : "VHOG:0001322" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005726", "lbl" : "chemosensory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BILA:0000139" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005728", "lbl" : "extraembryonic mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000474" + }, { + "val" : "EMAPA:31862" + }, { + "val" : "EMAPA:31863" + }, { + "val" : "FMA:296719" + }, { + "val" : "VHOG:0000616" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005729", "lbl" : "pectoral appendage field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0001453" + }, { + "val" : "ZFA:0001453" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005732", "lbl" : "paired limb/fin field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ring of cells capable of forming a limb or paired fin[Gilbert,modified].", + "xrefs" : [ "ISBN:9780878932504" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005734", "lbl" : "tunica adventitia of blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The outermost layer of a blood vessel, composed mainly of fibrous tissue.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Tunica_externa_(vessels)" ] + }, + "xrefs" : [ { + "val" : "BTO:0002010" + }, { + "val" : "EMAPA:36299" + }, { + "val" : "NCIT:C33818" + }, { + "val" : "SCTID:61066005" + }, { + "val" : "Wikipedia:Tunica_externa_(vessels)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005740", "lbl" : "tunica intima of artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica intima that is part of a artery.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36293" + }, { + "val" : "EV:0100028" + }, { + "val" : "FMA:14272" + }, { + "val" : "SCTID:40022005" + }, { + "val" : "galen:IntimaOfArtery" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005742", "lbl" : "adventitia", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An outermost connective tissue covering of an organ, vessel, or other structure[WP].", + "xrefs" : [ "Wikipedia:Adventitia" ] + }, + "xrefs" : [ { + "val" : "BTO:0002010" + }, { + "val" : "FMA:45635" + }, { + "val" : "SCTID:30180000" + }, { + "val" : "Wikipedia:Adventitia" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005744", "lbl" : "bone foramen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves.", + "xrefs" : [ "TAO:curator" ] + }, + "xrefs" : [ { + "val" : "AAO:0010438" + }, { + "val" : "TAO:0001736" + }, { + "val" : "VHOG:0001760" + }, { + "val" : "ZFA:0005386" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005764", "lbl" : "acellular membrane", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "An acellular anatomical structure that is the bounding layer of a anatomical structure.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63871" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005769", "lbl" : "basement membrane of epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina.", + "xrefs" : [ "Wikipedia:Basement_membrane", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010596" + }, { + "val" : "FMA:63872" + }, { + "val" : "GAID:915" + }, { + "val" : "NCIT:C13191" + }, { + "val" : "SCTID:68989006" + }, { + "val" : "Wikipedia:Basement_membrane" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005800", "lbl" : "section of aorta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle.", + "xrefs" : [ "ncithesaurus:Aortic_Segment" ] + }, + "xrefs" : [ { + "val" : "FMA:13087" + }, { + "val" : "NCIT:C34027" + }, { + "val" : "SCTID:119203005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005805", "lbl" : "dorsal aorta", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.", + "xrefs" : [ "GO:0035907", "https://sourceforge.net/p/geneontology/ontology-requests/8525/" ] + }, + "xrefs" : [ { + "val" : "AAO:0011029" + }, { + "val" : "BTO:0004673" + }, { + "val" : "EHDAA:402" + }, { + "val" : "EMAPA:18606" + }, { + "val" : "SCTID:338637006" + }, { + "val" : "TAO:0000014" + }, { + "val" : "VHOG:0000264" + }, { + "val" : "Wikipedia:Dorsal_aorta" + }, { + "val" : "XAO:0000051" + }, { + "val" : "ZFA:0000014" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005806", + "lbl" : "portal system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP].", + "xrefs" : [ "Wikipedia:Portal_venous_system" ] + }, + "xrefs" : [ { + "val" : "FMA:45628" + }, { + "val" : "MESH:D011168" + }, { + "val" : "NCIT:C33344" + }, { + "val" : "SCTID:362063001" + }, { + "val" : "Wikipedia:Portal_venous_system" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005844", "lbl" : "spinal cord segment", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BIRNLEX:2665" + }, { + "val" : "FMA:62420" + }, { + "val" : "MA:0003080" + }, { + "val" : "SCTID:278748001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005845", + "lbl" : "caudal segment of spinal cord", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A spinal cord segment that adjacent_to a caudal region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "for spinal cord segments, we treat coccygeal/caudal as synonyms - we only differentiate where bone is concerned" ], + "xrefs" : [ { + "val" : "FMA:256635" + }, { + "val" : "MA:0003084" + }, { + "val" : "SCTID:278753006" + }, { + "val" : "neuronames:1656" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005856", "lbl" : "developing mesenchymal condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A delimited region of dense mesenchyme within looser mesenchyme.", + "xrefs" : [ "AEO:0000148" ] + }, + "xrefs" : [ { + "val" : "AEO:0000148" + }, { + "val" : "EHDAA2_RETIRED:0003148" + }, { + "val" : "EHDAA:8979" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005863", "lbl" : "cartilaginous condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes.", + "xrefs" : [ "GO:curator" ] + }, + "xrefs" : [ { + "val" : "AEO:0000147" + }, { + "val" : "EHDAA2_RETIRED:0003147" + }, { + "val" : "EMAPA:32731" + }, { + "val" : "VSAO:0000092" + }, { + "val" : "XAO:0004022" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005865", "lbl" : "pre-muscle condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "AEO:0000149" + }, { + "val" : "EHDAA2_RETIRED:0003149" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005866", "lbl" : "pre-cartilage condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts.", + "xrefs" : [ "AEO:0000150", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000150" + }, { + "val" : "EHDAA2:0003150" + }, { + "val" : "EMAPA:32736" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005867", "lbl" : "mandibular prominence", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010939" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001061" + }, { + "val" : "EHDAA:5871" + }, { + "val" : "EMAPA:17355" + }, { + "val" : "FMA:293051" + }, { + "val" : "NCIT:C34204" + }, { + "val" : "Wikipedia:Mandibular_prominence" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005868", + "lbl" : "maxillary prominence", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw.", + "xrefs" : [ "ISBN:0-683-40008-8", "MP:0010940" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001070" + }, { + "val" : "EHDAA:5877" + }, { + "val" : "EMAPA:17359" + }, { + "val" : "FMA:293049" + }, { + "val" : "NCIT:C34206" + }, { + "val" : "SCTID:346355001" + }, { + "val" : "Wikipedia:Maxillary_prominence" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005902", "lbl" : "occipital region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles.", + "xrefs" : [ "TAO:0001414", "UBERONREF:0000007" ] + }, + "xrefs" : [ { + "val" : "AAO:0010199" + }, { + "val" : "BTO:0004675" + }, { + "val" : "FMA:49187" + }, { + "val" : "SCTID:362618001" + }, { + "val" : "TAO:0001414" + }, { + "val" : "XAO:0003173" + }, { + "val" : "ZFA:0001414" + }, { + "val" : "neuronames:2431" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005906", "lbl" : "serous sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA].", + "xrefs" : [ "FMA:9689", "https://github.com/obophenotype/uberon/issues/86" ] + }, + "comments" : [ "See notes for serous membrane" ], + "xrefs" : [ { + "val" : "FMA:9689" + }, { + "val" : "SCTID:362890006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005911", "lbl" : "endo-epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA].", + "xrefs" : [ "FMA:69065" ] + }, + "xrefs" : [ { + "val" : "FMA:69065" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005944", "lbl" : "axial skeleton plus cranial skeleton", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified].", + "xrefs" : [ "FMA:71221", "VSAO:0000056", "Wikipedia:Axial_skeleton", "https://github.com/obophenotype/uberon/issues/44", "https://github.com/obophenotype/uberon/wiki/The-axial-skeleton" ] + }, + "xrefs" : [ { + "val" : "AAO:0000963" + }, { + "val" : "EMAPA:17214" + }, { + "val" : "MA:0000308" + }, { + "val" : "NCIT:C32172" + }, { + "val" : "SCTID:361725000" + }, { + "val" : "VSAO:0000056" + }, { + "val" : "Wikipedia:Axial_skeleton" + }, { + "val" : "XAO:0004011" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005945", + "lbl" : "neurocranial trabecula", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EFO:0003677" + }, { + "val" : "TAO:0001321" + }, { + "val" : "ZFA:0001321" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005946", "lbl" : "outflow tract of atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An outflow tract that is part of a cardiac atrium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14141" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005953", "lbl" : "outflow part of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk.", + "xrefs" : [ "MP:0010428" ] + }, + "xrefs" : [ { + "val" : "FMA:7216" + }, { + "val" : "NCIT:C61368" + }, { + "val" : "SCTID:244379003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005956", "lbl" : "outflow part of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta.", + "xrefs" : [ "MP:0010429" ] + }, + "xrefs" : [ { + "val" : "FMA:9473" + }, { + "val" : "SCTID:264070001" + }, { + "val" : "Wikipedia:Aortic_vestibule" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005965", "lbl" : "outflow part of right atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA].", + "xrefs" : [ "FMA:9550", "FMA:FMA" ] + }, + "xrefs" : [ { + "val" : "FMA:9550" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005966", "lbl" : "outflow part of left atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An outflow tract of atrium that is part of a left atrium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:9551" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005979", "lbl" : "crista terminalis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium.", + "xrefs" : [ "MP:0010495" ] + }, + "xrefs" : [ { + "val" : "FMA:9236" + }, { + "val" : "SCTID:277693004" + }, { + "val" : "Wikipedia:Crista_terminalis" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005983", "lbl" : "heart layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The laminar structure of the heart.", + "xrefs" : [ "MP:0010545" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005985", "lbl" : "coronary vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation.", + "xrefs" : [ "MP:0010551" ] + }, + "xrefs" : [ { + "val" : "MESH:D003331" + }, { + "val" : "Wikipedia:Coronary_circulation" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "lbl" : "atrium myocardial trabecula", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The supporting bundles of muscular fibers lining the walls of the atrial myocardium.", + "xrefs" : [ "MP:0010581", "ZFA:0005810" ] + }, + "xrefs" : [ { + "val" : "ZFA:0005810" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0005989", "lbl" : "atrioventricular septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve.", + "xrefs" : [ "MP:0010592" ] + }, + "xrefs" : [ { + "val" : "FMA:7136" + }, { + "val" : "SCTID:280151006" + }, { + "val" : "Wikipedia:Atrioventricular_septum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006002", "lbl" : "vitelline artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The paired arteries that carry blood to the yolk sac from the dorsal aorta.", + "xrefs" : [ "MP:0010664", "Wikipedia:Vitelline_arteries" ] + }, + "comments" : [ "Development notes:; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult[MP:0010664]" ], + "xrefs" : [ { + "val" : "EHDAA2:0002208" + }, { + "val" : "EMAPA:16207" + }, { + "val" : "Wikipedia:Vitelline_arteries" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006003", "lbl" : "integumentary adnexa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers.", + "xrefs" : [ "http://code.google.com/p/caro2/issues/detail?id=5", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Skin_appendage" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006056", "lbl" : "posterior surface of head", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006068", + "lbl" : "bone of tail", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a post-anal tail.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18042" + }, { + "val" : "MA:0000696" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006071", + "lbl" : "caudal region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "XAO:0000087" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "lbl" : "cervical region of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "That portion of the spine comprising the cervical vertebrae. The neck area of the spine.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/" ] + }, + "xrefs" : [ { + "val" : "AAO:0000092" + }, { + "val" : "BTO:0004148" + }, { + "val" : "EHDAA2:0000238" + }, { + "val" : "EHDAA:5051" + }, { + "val" : "EMAPA:17215" + }, { + "val" : "FMA:24138" + }, { + "val" : "MA:0003154" + }, { + "val" : "NCIT:C69313" + }, { + "val" : "SCTID:260488005" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "lbl" : "thoracic region of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "That part of the spine comprising the thoracic vertebrae.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/" ] + }, + "xrefs" : [ { + "val" : "BTO:0004150" + }, { + "val" : "EHDAA:5063" + }, { + "val" : "EMAPA:17396" + }, { + "val" : "FMA:9140" + }, { + "val" : "MA:0003155" + }, { + "val" : "NCIT:C69315" + }, { + "val" : "SCTID:243931006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "lbl" : "caudal region of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae.", + "xrefs" : [ "UBERONREF:0000006" ] + }, + "xrefs" : [ { + "val" : "AAO:0000082" + }, { + "val" : "EMAPA:18043" + }, { + "val" : "MA:0003158" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "lbl" : "subdivision of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of all skeletal elements in some subdivision of the vertebral column.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:16201" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006207", "lbl" : "aortico-pulmonary spiral septum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions.", + "xrefs" : [ "MP:0010650", "Wikipedia:Aorticopulmonary_septum" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2409" + }, { + "val" : "EHDAA2:0000136" + }, { + "val" : "EHDAA:2592" + }, { + "val" : "EMAPA:16827" + }, { + "val" : "VHOG:0000502" + }, { + "val" : "Wikipedia:Aorticopulmonary_septum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006211", "lbl" : "buccopharyngeal membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx.", + "xrefs" : [ "MP:0012521" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000189" + }, { + "val" : "EHDAA:536" + }, { + "val" : "EMAPA:16259" + }, { + "val" : "FMA:313607" + }, { + "val" : "SCTID:361412007" + }, { + "val" : "VHOG:0000380" + }, { + "val" : "Wikipedia:Buccopharyngeal_membrane" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006218", "lbl" : "common atrial chamber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA:1267" + }, { + "val" : "EMAPA:16342" + }, { + "val" : "RETIRED_EHDAA2:0000268" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "lbl" : "ethmoid bone primordium", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000456" + }, { + "val" : "EHDAA:8363" + }, { + "val" : "EMAPA:18023" + }, { + "val" : "FMA:312597" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "lbl" : "foregut-midgut junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junctions that overlaps the foregut and midgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000569" + }, { + "val" : "EHDAA:526" + }, { + "val" : "EMAPA:16363" + }, { + "val" : "VHOG:0000291" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006236", + "lbl" : "tetrapod frontal bone primordium", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000577" + }, { + "val" : "EHDAA:9540" + }, { + "val" : "EMAPA:18017" + }, { + "val" : "FMA:312589" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006238", "lbl" : "future brain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic precursor of the brain.", + "xrefs" : [ "NLX:94995" ] + }, + "xrefs" : [ { + "val" : "BAMS:Enc" + }, { + "val" : "BTO:0004726" + }, { + "val" : "EFO:0003431" + }, { + "val" : "EHDAA:300" + }, { + "val" : "EHDAA:830" + }, { + "val" : "EMAPA:16089" + }, { + "val" : "FMA:312967" + }, { + "val" : "RETIRED_EHDAA2:0000591" + }, { + "val" : "TAO:0000146" + }, { + "val" : "ZFA:0000146" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006239", "lbl" : "future central tendon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tendon that has the potential to develop into a central tendon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000593" + }, { + "val" : "EHDAA:4118" + }, { + "val" : "EMAPA:25035" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006241", "lbl" : "future spinal cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EFO:0003438" + }, { + "val" : "EHDAA2:0000674" + }, { + "val" : "EHDAA:898" + }, { + "val" : "EMAPA:16092" + }, { + "val" : "EMAPA:16755" + }, { + "val" : "TAO:0000417" + }, { + "val" : "ZFA:0000417" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "lbl" : "gallbladder primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops.", + "xrefs" : [ "ISBN:0815318960", "XAO:0004205" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000700" + }, { + "val" : "EHDAA:3047" + }, { + "val" : "EMAPA:16713" + }, { + "val" : "XAO:0004205" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006264", "lbl" : "mouth-foregut junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junctions that overlaps the mouth and foregut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:534" + }, { + "val" : "EMAPA:16258" + }, { + "val" : "RETIRED_EHDAA2:0001205" + }, { + "val" : "VHOG:0000592" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006267", "lbl" : "notochordal plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.", + "xrefs" : [ "VHOG:0001212" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001278" + }, { + "val" : "EHDAA:264" + }, { + "val" : "EMAPA:16101" + }, { + "val" : "NCIT:C34231" + }, { + "val" : "VHOG:0001212" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006268", "lbl" : "notochordal process", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.", + "xrefs" : [ "http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/05embryonicperiod.htm" ] + }, + "comments" : [ "The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus." ], + "xrefs" : [ { + "val" : "EHDAA2:0001279" + }, { + "val" : "EHDAA:224" + }, { + "val" : "EMAPA:16102" + }, { + "val" : "FMA:293135" + }, { + "val" : "NCIT:C34232" + }, { + "val" : "VHOG:0001213" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006271", + "lbl" : "orbital fissure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Either of two openings transmitting nerves and blood vessels to or from the orbit.", + "xrefs" : [ "http://www.merriam-webster.com/medical/orbital%20fissure" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001328" + }, { + "val" : "EHDAA:10648" + }, { + "val" : "EMAPA:18717" + }, { + "val" : "SCTID:280546005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006279", "lbl" : "pleuroperitoneal canal", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity.", + "xrefs" : [ "ISBN:0124020607", "VHOG:0001505" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001481" + }, { + "val" : "EHDAA:4128" + }, { + "val" : "EMAPA:17707" + }, { + "val" : "SCTID:361413002" + }, { + "val" : "VHOG:0001505" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006283", "lbl" : "future cardiac ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle.", + "xrefs" : [ "ZFA:0001719" ] + }, + "comments" : [ "The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum[WP]" ], + "xrefs" : [ { + "val" : "EHDAA2:0001531" + }, { + "val" : "EMAPA:16350" + }, { + "val" : "FMA:71006" + }, { + "val" : "NCIT:C34160" + }, { + "val" : "SCTID:361524003" + }, { + "val" : "TAO:0002231" + }, { + "val" : "Wikipedia:Embryonic_ventricle" + }, { + "val" : "ZFA:0001719" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "lbl" : "spleen primordium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP].", + "xrefs" : [ "ISBN:0123747295", "MP:0011263" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001904" + }, { + "val" : "EHDAA:3003" + }, { + "val" : "EMAPA:18535" + }, { + "val" : "XAO:0000326" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006304", "lbl" : "future trigeminal ganglion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/13 and https://github.com/obophenotype/uberon/issues/693 -- consider merging into trigeminal ganglion, as this complicates the model" ], + "xrefs" : [ { + "val" : "EHDAA:924" + }, { + "val" : "EMAPA:16663" + }, { + "val" : "RETIRED_EHDAA2:0002089" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006311", "lbl" : "chamber of eyeball", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A segment of the eyeball that is filled with refractive media.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0002085" + }, { + "val" : "FMA:58071" + }, { + "val" : "MA:0002459" + }, { + "val" : "NCIT:C32301" + }, { + "val" : "SCTID:280540004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006312", "lbl" : "ocular refractive media", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Body substance in a liquid or semi-solid state in the eyeball which serves to refract light.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0001911" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006314", "lbl" : "bodily fluid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.", + "xrefs" : [ "MESH:A12.207", "Wikipedia:Body_fluid" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:20" + }, { + "val" : "FMA:280556" + }, { + "val" : "GAID:266" + }, { + "val" : "MESH:D001826" + }, { + "val" : "Wikipedia:Body_fluid" + }, { + "val" : "galen:BodyFluid" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006331", "lbl" : "brainstem nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nucleus of brain that is part of a brainstem.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32790" + }, { + "val" : "MA:0000821" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006347", "lbl" : "communicating artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that connects two larger arteries.", + "xrefs" : [ "ncithesaurus:Communicating_Artery" ] + }, + "comments" : [ "Grouping for anterior and posterior" ], + "xrefs" : [ { + "val" : "EMAPA:18598" + }, { + "val" : "MA:0001938" + }, { + "val" : "NCIT:C52851" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006518", "lbl" : "right lung lobe", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lobe of lung that is part of a right lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35155" + }, { + "val" : "MA:0001791" + }, { + "val" : "NCIT:C48944" + }, { + "val" : "SCTID:272654004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006524", "lbl" : "alveolar system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "System pertaining to a bronchus and alveoli.", + "xrefs" : [ "BTO:0000136" ] + }, + "xrefs" : [ { + "val" : "BTO:0000136" + }, { + "val" : "CALOHA:TS-1296" + }, { + "val" : "EMAPA:32692" + }, { + "val" : "MA:0000416" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006525", "lbl" : "left lung alveolar system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:19001" + }, { + "val" : "MA:0001775" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006526", "lbl" : "right lung alveolar system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:35717" + }, { + "val" : "MA:0001784" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006535", "lbl" : "skin secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of organism substance that secreted_by a zone of skin.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002537" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006537", "lbl" : "female reproductive gland secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of organism substance that is secreted by a female reproductive gland.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "MA:0002510" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006538", "lbl" : "respiratory system fluid/secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of organism substance that secreted_by a respiratory system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36550" + }, { + "val" : "MA:0002533" + }, { + "val" : "NCIT:C13722" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006555", + "lbl" : "excretory tube", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tube that is part of a excretory system.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006562", "lbl" : "pharynx", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pharynx is the part of the digestive system immediately posterior to the mouth[GO].", + "xrefs" : [ "GO:0060465" ] + }, + "xrefs" : [ { + "val" : "MAT:0000049" + }, { + "val" : "MESH:D010614" + }, { + "val" : "MIAA:0000049" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006563", "lbl" : "tunica media of pulmonary trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA].", + "xrefs" : [ "FMA:85030", "FMA:FMA" ] + }, + "xrefs" : [ { + "val" : "FMA:85030" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006566", "lbl" : "left ventricle myocardium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A myocardium that is part of a left ventricle of a heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:9558" + }, { + "val" : "MA:0002983" + }, { + "val" : "SCTID:362021000" } ] } }, { @@ -21211,577 +74511,2732 @@ "lbl" : "right ventricle myocardium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A myocardium that is part of a right ventricle of a heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:9535" + }, { + "val" : "MA:0002984" + }, { + "val" : "SCTID:362020004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006570", + "lbl" : "trabecula carnea of right ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A trabecula carnea that is part of a heart right ventricle.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7270" + }, { + "val" : "SCTID:192373001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006571", + "lbl" : "trabecula carnea of left ventricle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A trabecula carnea that is part of a heart left ventricle.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7271" + }, { + "val" : "SCTID:190344008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "lbl" : "pectinate line", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:.", + "xrefs" : [ "Wikipedia:Pectinate_line" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19159" + }, { + "val" : "FMA:75383" + }, { + "val" : "NCIT:C34245" + }, { + "val" : "SCTID:245445008" + }, { + "val" : "Wikipedia:Pectinate_line" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006595", "lbl" : "presumptive endoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Presumptive structure of the blastula that will develop into endoderm.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000471" + }, { + "val" : "EFO:0003437" + }, { + "val" : "TAO:0000416" + }, { + "val" : "ZFA:0000416" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006596", "lbl" : "presumptive blood", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "AAO:0000468" + }, { + "val" : "EFO:0003439" + }, { + "val" : "TAO:0000568" + }, { + "val" : "ZFA:0000568" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006598", "lbl" : "presumptive structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of embryonic tissue determined by fate mapping to become a structure.", + "xrefs" : [ "GOC:CVS", "GOC:YMB", "ZFA:0001116" ] + }, + "xrefs" : [ { + "val" : "AAO:0000479" + }, { + "val" : "TAO:0001116" + }, { + "val" : "ZFA:0001116" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006601", "lbl" : "presumptive ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Presumptive structure of the blastula that will develop into ectoderm.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000470" + }, { + "val" : "EFO:0003466" + }, { + "val" : "TAO:0001376" + }, { + "val" : "XAO:0004132" + }, { + "val" : "ZFA:0001376" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006603", "lbl" : "presumptive mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Presumptive structure of the blastula that will develop into mesoderm.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000476" + }, { + "val" : "EFO:0003467" + }, { + "val" : "TAO:0001377" + }, { + "val" : "ZFA:0001377" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006660", + "lbl" : "muscular coat", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis.", + "xrefs" : [ "Wikipedia:Muscular_layer" ] + }, + "xrefs" : [ { + "val" : "BTO:0004838" + }, { + "val" : "SCTID:86915006" + }, { + "val" : "Wikipedia:Muscular_layer" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006670", "lbl" : "central tendon of diaphragm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers.", + "xrefs" : [ "MGI:csmith", "MP:0012061" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17702" + }, { + "val" : "FMA:58279" + }, { + "val" : "NCIT:C34119" + }, { + "val" : "SCTID:244943002" + }, { + "val" : "VHOG:0001399" + }, { + "val" : "Wikipedia:Central_tendon_of_diaphragm" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006677", "lbl" : "surface of epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical boundary that adjacent_to a epithelium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:70997" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006686", + "lbl" : "spinal vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a vertebral column.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18255" + }, { + "val" : "FMA:76735" + }, { + "val" : "MA:0002108" + }, { + "val" : "SCTID:181376008" + }, { + "val" : "Wikipedia:Spinal_veins" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006761", "lbl" : "corneo-scleral junction", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm.", + "xrefs" : [ "MP:0013477" ] + }, + "comments" : [ "This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343" ], + "xrefs" : [ { + "val" : "EFO:0001403" + }, { + "val" : "FMA:58342" + }, { + "val" : "GAID:896" + }, { + "val" : "MESH:D016850" + }, { + "val" : "SCTID:63716004" + }, { + "val" : "Wikipedia:Corneal_limbus" + }, { + "val" : "ZFA:0005570" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006799", "lbl" : "glandular epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is composed primarily of secretory cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0002991" + }, { + "val" : "NCIT:C43370" + }, { + "val" : "NCIT:C45715" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006815", "lbl" : "areolar connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand.", + "xrefs" : [ "FMA:63897" ] + }, + "xrefs" : [ { + "val" : "AAO:0000027" + }, { + "val" : "FMA:63897" + }, { + "val" : "SCTID:68477002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006828", + "lbl" : "trabecula carnea of atrium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The supporting bundles of muscular fibers lining the walls of the atria[MP].", + "xrefs" : [ "MP:0010581" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006833", "lbl" : "lumen of trachea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that surrounded_by a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:7469" + }, { + "val" : "SCTID:197486000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006834", "lbl" : "uterus or analog", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of a the reproductive tract in a female organism that is the site of embryo development.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TADS:0000421" + }, { + "val" : "WBbt:0006760" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006841", + "lbl" : "central vein of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vein that is central to a lobule in the liver.", + "xrefs" : [ "ZFA:0005168" ] + }, + "xrefs" : [ { + "val" : "FMA:17544" + }, { + "val" : "NCIT:C32281" + }, { + "val" : "SCTID:272023004" + }, { + "val" : "TAO:0005168" + }, { + "val" : "Wikipedia:Central_veins_of_liver" + }, { + "val" : "ZFA:0005168" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006846", "lbl" : "surface groove", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A furrow or an incomplete tube.", + "xrefs" : [ "AEO:0000161", "AEO:JB", "https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/4" ] + }, + "comments" : [ "Surface groove is modelled as immaterial - see https://github.com/obophenotype/uberon/issues/2667 for discussion" ], + "xrefs" : [ { + "val" : "AEO:0000161" + }, { + "val" : "EHDAA2_RETIRED:0003161" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006866", + "lbl" : "terminal part of digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "WBbt:0005773" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006876", "lbl" : "vasculature of organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a organ.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:74612" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0006877", + "lbl" : "vasculature of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0003454" + }, { + "val" : "EMAPA:35501" + }, { + "val" : "FMA:73748" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006904", "lbl" : "head mesenchyme from mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A head mesenchyme that develops_from a mesoderm.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0011051" + }, { + "val" : "EFO:0003337" + }, { + "val" : "EFO:0003603" + }, { + "val" : "EHDAA2:0001118" + }, { + "val" : "EHDAA:655" + }, { + "val" : "EMAPA:16099" + }, { + "val" : "EMAPA_RETIRED:16270" + }, { + "val" : "FMA:293859" + }, { + "val" : "TAO:0000998" + }, { + "val" : "VHOG:0000185" + }, { + "val" : "XAO:0000053" + }, { + "val" : "ZFA:0000998" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006905", "lbl" : "mandibular process mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a mandibular prominence.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001062" + }, { + "val" : "EHDAA:5861" + }, { + "val" : "EHDAA:5873" + }, { + "val" : "EMAPA:17357" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006909", "lbl" : "lumen of digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that surrounded_by a digestive tract.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0000349" + }, { + "val" : "EMAPA:32908" + }, { + "val" : "FMA:45677" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006913", "lbl" : "lip epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a lip.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004468" + }, { + "val" : "TAO:0005334" + }, { + "val" : "ZFA:0005334" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006914", "lbl" : "squamous epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium characterised by its most superficial layer consisting of squamous epithelial cells.", + "xrefs" : [ "Wikipedia:Squamous_epithelium" ] + }, + "xrefs" : [ { + "val" : "BTO:0002072" + }, { + "val" : "NCIT:C12848" + }, { + "val" : "SCTID:40118003" + }, { + "val" : "Wikipedia:Squamous_epithelium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006915", "lbl" : "stratified squamous epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA].", + "xrefs" : [ "FMA:45563", "Wikipedia:Stratified_squamous_epithelium" ] + }, + "xrefs" : [ { + "val" : "FMA:45563" + }, { + "val" : "NCIT:C13180" + }, { + "val" : "Wikipedia:Stratified_squamous_epithelium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006920", "lbl" : "esophagus squamous epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A squamous epithelium that is part of a esophagus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0003635" + }, { + "val" : "CALOHA:TS-1250" + }, { + "val" : "EMAPA:35324" + }, { + "val" : "MA:0001567" + }, { + "val" : "NCIT:C49222" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006921", "lbl" : "stomach squamous epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A squamous epithelium that is part of a stomach.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35824" + }, { + "val" : "MA:0001611" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006924", "lbl" : "stomach glandular epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands.", + "xrefs" : [ "ISBN:0073040584" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35814" + }, { + "val" : "FMA:63458" + }, { + "val" : "MA:0002784" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006925", "lbl" : "digestive system gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any gland that is part of the digestive system.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "AAO:0000130" + }, { + "val" : "BTO:0000345" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006929", "lbl" : "glandular columnar epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA].", + "xrefs" : [ "FMA:64800" ] + }, + "xrefs" : [ { + "val" : "FMA:64800" + }, { + "val" : "NCIT:C13182" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006930", "lbl" : "glandular cuboidal epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:66809" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006931", "lbl" : "stomach glandular region mucosa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27167" + }, { + "val" : "MA:0001614" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006934", "lbl" : "sensory epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue.", + "xrefs" : [ "BTO:0000314" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0682" + }, { + "val" : "FMA:62410" + }, { + "val" : "SCTID:309045006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006960", "lbl" : "ovary stroma", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis.", + "xrefs" : [ "Wikipedia:Stroma_of_ovary" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-1246" + }, { + "val" : "EMAPA:28880" + }, { + "val" : "FMA:18626" + }, { + "val" : "MA:0002991" + }, { + "val" : "NCIT:C33638" + }, { + "val" : "SCTID:259306002" + }, { + "val" : "Wikipedia:Stroma_of_ovary" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006965", "lbl" : "vascular cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA].", + "xrefs" : [ "GO:0072360", "ZFA:0005077" ] + }, + "xrefs" : [ { + "val" : "EFO:0003709" + }, { + "val" : "TAO:0005077" + }, { + "val" : "ZFA:0005077" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006966", "lbl" : "coronary capillary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of the coronary system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "ZFA:0005813" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0006984", "lbl" : "anatomical surface", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n.", + "xrefs" : [ "CARO:0001002" ] + }, + "comments" : [ "Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism." ], + "xrefs" : [ { + "val" : "BILA:0000010" + }, { + "val" : "CARO:0001002" + }, { + "val" : "EHDAA2_RETIRED:0003192" + }, { + "val" : "FMA:24137" + }, { + "val" : "NCIT:C34022" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007005", "lbl" : "cardiogenic splanchnic mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO].", + "xrefs" : [ "XAO:0000235", "http://www.drugs.com/dict/cardiogenic-mesoderm.html", "https://github.com/obophenotype/insect_neuroanatomy_ontology/issues/7" ] + }, + "xrefs" : [ { + "val" : "AAO:0011021" + }, { + "val" : "BILA:0000051" + }, { + "val" : "EFO:0000315" + }, { + "val" : "EHDAA2:0000214" + }, { + "val" : "EHDAA:385" + }, { + "val" : "FMA:293143" + }, { + "val" : "SCTID:360387000" + }, { + "val" : "VHOG:0001641" + }, { + "val" : "XAO:0000235" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007010", "lbl" : "cleaving embryo", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Organism at the cleavage stage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BILA:0000058" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007026", "lbl" : "presumptive gut", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BILA:0000084" + }, { + "val" : "NCIT:C34268" + }, { + "val" : "SCTID:360394002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007037", "lbl" : "mechanosensory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BILA:0000142" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007098", "lbl" : "mandibular neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cranial neural crest that migrates into the mandibular arch.", + "xrefs" : [ "ZFA:0007064" ] + }, + "xrefs" : [ { + "val" : "TAO:0007064" + }, { + "val" : "XAO:0000024" + }, { + "val" : "ZFA:0007064" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007100", "lbl" : "primary circulatory organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].", + "xrefs" : [ "GO:0007507" ] + }, + "comments" : [ "Gene notes: Bmp, Nkx, Gata" ], + "xrefs" : [ { + "val" : "TADS:0000147" + }, { + "val" : "http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007134", "lbl" : "trunk ganglion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ganglion which is located in the trunk.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "EFO:0000901" + }, { + "val" : "MAT:0000344" + }, { + "val" : "MIAA:0000344" + }, { + "val" : "TAO:0001573" + }, { + "val" : "ZFA:0001573" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007135", "lbl" : "neural keel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section.", + "xrefs" : [ "ZFIN:ZDB-PUB-961014-576" ] + }, + "xrefs" : [ { + "val" : "EFO:0003497" + }, { + "val" : "TAO:0000131" + }, { + "val" : "ZFA:0000131" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007144", + "lbl" : "embryonic post-anal tail", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16748" + }, { + "val" : "FMA:85540" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007147", + "lbl" : "lumen of midgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a midgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18377" + }, { + "val" : "FMA:54366" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007148", + "lbl" : "lumen of hindgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a hindgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18396" + }, { + "val" : "FMA:54367" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007158", + "lbl" : "lumen of anal canal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a anal canal.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18836" + }, { + "val" : "FMA:17357" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007159", + "lbl" : "lumen of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a colon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18945" + }, { + "val" : "FMA:18374" + }, { + "val" : "SCTID:362156004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007177", + "lbl" : "lamina propria of mucosa of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a colonic mucosa.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27395" + }, { + "val" : "FMA:15657" + }, { + "val" : "MA:0003196" + }, { + "val" : "SCTID:113284008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007188", "lbl" : "mesothelium of serous pericardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesothelium that is part of a serous pericardium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0003157" + }, { + "val" : "EMAPA:16133" + }, { + "val" : "FMA:18149" + }, { + "val" : "SCTID:67300002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007195", "lbl" : "stroma of bone marrow", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis.", + "xrefs" : [ "Wikipedia:Bone_marrow#Stroma" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0085" + }, { + "val" : "FMA:21426" + }, { + "val" : "Wikipedia:Bone_marrow#Stroma" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007196", "lbl" : "tracheobronchial tree", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells.", + "xrefs" : [ "Wikipedia:Tracheobronchial_tree" ] + }, + "xrefs" : [ { + "val" : "FMA:7393" + }, { + "val" : "NCIT:C117875" + }, { + "val" : "SCTID:361384001" + }, { + "val" : "Wikipedia:Tracheobronchial_tree" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007204", "lbl" : "brachiocephalic vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The vasculature consisting of brachiocephalic arteries and veins.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007213", "lbl" : "mesenchyme derived from head neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a cranial neural crest.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003572" + }, { + "val" : "EHDAA2:0000735" + }, { + "val" : "EMAPA:16169" + }, { + "val" : "EMAPA:16271" + }, { + "val" : "EMAPA_RETIRED:16271" + }, { + "val" : "TAO:0000787" + }, { + "val" : "ZFA:0000787" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007214", "lbl" : "mesenchyme derived from trunk neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a trunk neural crest.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002093" + }, { + "val" : "EMAPA:16182" + }, { + "val" : "TAO:0000999" + }, { + "val" : "ZFA:0000999" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007237", "lbl" : "1st arch mandibular component", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000031" + }, { + "val" : "EHDAA:583" + }, { + "val" : "EMAPA:16382" + }, { + "val" : "VHOG:0000510" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007238", + "lbl" : "1st arch maxillary component", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000038" + }, { + "val" : "EHDAA:595" + }, { + "val" : "EMAPA:16388" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007239", "lbl" : "tunica media of artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica media that is part of a artery.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36294" + }, { + "val" : "EV:0100029" + }, { + "val" : "FMA:14273" + }, { + "val" : "NCIT:C49321" + }, { + "val" : "SCTID:84300001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007240", "lbl" : "tunica adventitia of artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica adventitia that is part of a artery.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36295" + }, { + "val" : "EV:0100030" + }, { + "val" : "FMA:14274" + }, { + "val" : "SCTID:113261001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007241", "lbl" : "tunica adventitia of vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica adventitia that is part of a vein.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36310" + }, { + "val" : "EV:0100034" + }, { + "val" : "FMA:14355" + }, { + "val" : "SCTID:13202006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007242", "lbl" : "tunica intima of vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica intima that is part of a vein.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36308" + }, { + "val" : "EV:0100032" + }, { + "val" : "FMA:14353" + }, { + "val" : "SCTID:2436009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007243", "lbl" : "tunica media of vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tunica media that is part of a vein.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36309" + }, { + "val" : "EV:0100033" + }, { + "val" : "FMA:14354" + }, { + "val" : "SCTID:42049001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007245", "lbl" : "nuclear complex of neuraxis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Gray matter of the central nervous system which is a collection of clustered nuclei.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:256381" + }, { + "val" : "FMA:84059" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007247", "lbl" : "nucleus of superior olivary complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:72246" + }, { + "val" : "SCTID:369024009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007267", "lbl" : "trachea pre-cartilage rings", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pre-cartilage condensation that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002070" + }, { + "val" : "EHDAA:7082" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007269", "lbl" : "pectoral appendage musculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a pectoral appendage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003540" + }, { + "val" : "TAO:0000563" + }, { + "val" : "ZFA:0000563" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007271", "lbl" : "appendage musculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of an appendage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0000207" + }, { + "val" : "ZFA:0000207" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007272", "lbl" : "pectoral appendage skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle.", + "xrefs" : [ "VSAO:0005000", "VSAO:NI" ] + }, + "xrefs" : [ { + "val" : "VSAO:0005000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007277", "lbl" : "presumptive hindbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure.", + "xrefs" : [ "Wikipedia:Rhombencephalon" ] + }, + "xrefs" : [ { + "val" : "BAMS:HB" + }, { + "val" : "CALOHA:TS-2118" + }, { + "val" : "EFO:0003440" + }, { + "val" : "EHDAA2:0001630" + }, { + "val" : "FMA:295640" + }, { + "val" : "TAO:0000569" + }, { + "val" : "Wikipedia:Rhombencephalon" + }, { + "val" : "ZFA:0000569" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007278", "lbl" : "presumptive sinus venosus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that is part of the heart tube and will become the sinus venosus.", + "xrefs" : [ "ZFA:0001722" ] + }, + "xrefs" : [ { + "val" : "TAO:0002234" + }, { + "val" : "ZFA:0001722" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007280", "lbl" : "presumptive endocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A presumptive structure that has the potential to develop into a endocardium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0002233" + }, { + "val" : "ZFA:0001724" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007281", "lbl" : "presumptive midbrain hindbrain boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Embryonic structure that gives rise to the midbrain hindbrain boundary.", + "xrefs" : [ "ZFA:0001187" ] + }, + "xrefs" : [ { + "val" : "EFO:0003446" + }, { + "val" : "TAO:0001187" + }, { + "val" : "XAO:0004086" + }, { + "val" : "ZFA:0001187" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007282", "lbl" : "presumptive segmental plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A presumptive structure that has the potential to develop into a presomitic mesoderm.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003421" + }, { + "val" : "TAO:0000053" + }, { + "val" : "ZFA:0000053" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007284", "lbl" : "presumptive neural plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A presumptive structure that has the potential to develop into a neural plate.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003424" + }, { + "val" : "TAO:0000063" + }, { + "val" : "ZFA:0000063" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007285", "lbl" : "presumptive paraxial mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the blastula that has the potential to develop into a paraxial mesoderm.", + "xrefs" : [ "UBERON:cjm", "https://github.com/obophenotype/uberon/issues/1277" ] + }, + "xrefs" : [ { + "val" : "EFO:0003443" + }, { + "val" : "TAO:0000591" + }, { + "val" : "XAO:0004134" + }, { + "val" : "ZFA:0000591" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007300", "lbl" : "pectoral appendage blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a pectoral appendage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005301" + }, { + "val" : "ZFA:0005301" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007301", "lbl" : "appendage blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a limb/fin.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005299" + }, { + "val" : "ZFA:0005299" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007302", "lbl" : "pectoral appendage vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a pectoral appendage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005096" + }, { + "val" : "ZFA:0005096" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007303", "lbl" : "pharyngeal vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a chordate pharynx.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005003" + }, { + "val" : "ZFA:0005003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007304", "lbl" : "appendage vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a limb/fin.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005095" + }, { + "val" : "ZFA:0005095" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "lbl" : "pancreatic lobule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans.", + "xrefs" : [ "ISBN:0123813611" ] + }, + "xrefs" : [ { + "val" : "FMA:16012" + }, { + "val" : "MA:0000721" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "lbl" : "pancreatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A duct that collects and carries secretions of the exocrine pancreas to the intestine.", + "xrefs" : [ "GOC:cvs", "GOC:ymb", "Wikipedia:Pancreatic_duct", "https://github.com/obophenotype/uberon/issues/1250", "https://orcid.org/0000-0002-2244-7917", "https://orcid.org/0000-0002-6601-2165", "https://orcid.org/0000-0002-9900-7880" ] + }, + "xrefs" : [ { + "val" : "EHDAA:9194" + }, { + "val" : "EMAPA:32952" + }, { + "val" : "FMA:10419" + }, { + "val" : "MA:0000124" + }, { + "val" : "SCTID:181278006" + }, { + "val" : "TAO:0001372" + }, { + "val" : "VHOG:0000254" + }, { + "val" : "Wikipedia:Pancreatic_duct" + }, { + "val" : "ZFA:0001372" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007375", + "lbl" : "roof of mouth", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2212" + }, { + "val" : "Wikipedia:Palate" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007376", "lbl" : "outer epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO].", + "xrefs" : [ "GO:0008544" ] + }, + "xrefs" : [ { + "val" : "BSA:0000073" + }, { + "val" : "BTO:0000313" + }, { + "val" : "HAO:0000298" + }, { + "val" : "TADS:0000109" + }, { + "val" : "WBbt:0005733" + }, { + "val" : "Wikipedia:Epidermis_(zoology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007383", "lbl" : "enveloping layer of ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Outermost layer of cells surrounding the embryo.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EFO:0003425" + }, { + "val" : "TAO:0000086" + }, { + "val" : "ZFA:0000086" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007389", "lbl" : "paired limb/fin cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage tissue that is part of a paired limb or fin.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001543" + }, { + "val" : "ZFA:0001543" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007390", "lbl" : "pectoral appendage cartilage tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage tissue that is part of a pectoral appendage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0000257" + }, { + "val" : "ZFA:0000257" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007414", "lbl" : "nucleus of midbrain tegmentum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nucleus of brain that spans a midbrain tegmentum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:258768" + }, { + "val" : "ZFA:0005577" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007473", "lbl" : "lumen of epithelial sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The space within an epithelial sphere.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000079" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007475", "lbl" : "matrix-based tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000081" + }, { + "val" : "EHDAA2:0003081" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007499", "lbl" : "epithelial sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial tube that is open at one end only.", + "xrefs" : [ "AEO:JB", "UBERONREF:0000001" ] + }, + "xrefs" : [ { + "val" : "AEO:0000115" + }, { + "val" : "EHDAA2:0003115" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007500", "lbl" : "epithelial tube open at both ends", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial tube open at both ends that allows fluid flow.", + "xrefs" : [ "AEO:JB", "UBERONREF:0000001" ] + }, + "xrefs" : [ { + "val" : "AEO_RETIRED:0000116" + }, { + "val" : "RETIRED_EHDAA2:0003116" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007503", "lbl" : "epithelial vesicle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A closed epithelium with a lumen.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000119" + }, { + "val" : "EHDAA2:0003119" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007521", + "lbl" : "smooth muscle sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ring of smooth muscle cells whose contraction closes the opening of the ring.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000143" + }, { + "val" : "EHDAA2:0003143" + }, { + "val" : "SCTID:362915001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007522", + "lbl" : "striated muscle sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ring of striated muscle cells whose contraction closes the opening of the ring.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000144" + }, { + "val" : "EHDAA2:0003144" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007524", "lbl" : "dense mesenchyme tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme with little extracellular matrix.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000146" + }, { + "val" : "EHDAA2:0003146" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007530", "lbl" : "migrating mesenchyme population", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchymal cells that are migrating.", + "xrefs" : [ "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000152" + }, { + "val" : "EHDAA2:0003152" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007592", "lbl" : "ciliated columnar epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA].", + "xrefs" : [ "FMA:64798" ] + }, + "xrefs" : [ { + "val" : "FMA:64798" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007601", "lbl" : "ciliated epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium bearing vibratile cilia on the free surface.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/ciliated+epithelium" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007616", "lbl" : "layer of synovial tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO].", + "xrefs" : [ "BTO:0001338", "http://www.britannica.com/EBchecked/topic/578563/synovial-tissue" ] + }, + "xrefs" : [ { + "val" : "BTO:0001338" + }, { + "val" : "CALOHA:TS-0998" + }, { + "val" : "FMA:66762" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007617", "lbl" : "synovial cavity of joint", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a synovial joint.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:11356" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007625", "lbl" : "pigment epithelium of eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules.", + "xrefs" : [ "MP:0005200" ] + }, + "xrefs" : [ { + "val" : "GAID:907" + }, { + "val" : "MESH:D010857" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007635", "lbl" : "nucleus of medulla oblongata", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural nucleus that is part of a medulla oblongata.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:258772" + }, { + "val" : "SCTID:304943004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007641", "lbl" : "trigeminal nuclear complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP].", + "xrefs" : [ "Wikipedia:Trigeminal_nerve_nuclei" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:4096" + }, { + "val" : "BM:V" + }, { + "val" : "CALOHA:TS-2077" + }, { + "val" : "DHBA:266441713" + }, { + "val" : "FMA:71248" + }, { + "val" : "HBA:9203" + }, { + "val" : "Wikipedia:Trigeminal_nerve_nuclei" + }, { + "val" : "neuronames:2021" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007651", "lbl" : "anatomical junction", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "definition" : { + "val" : "An anatomical structure that connects two structures.", + "xrefs" : [ "http://code.google.com/p/caro2/issues/detail?id=15" ] + }, + "xrefs" : [ { + "val" : "FMA:5898" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "SCTID:91833003" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007652", + "lbl" : "esophageal sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphincter that is part of an esophagus.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "SCTID:277765007" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007688", "lbl" : "anlage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue.", + "xrefs" : [ "FBbt:00005426", "http://flybase.org/reports/FBrf0178740.html" ] + }, + "xrefs" : [ { + "val" : "AEO:0000170" + }, { + "val" : "EFO:0001649" + }, { + "val" : "EHDAA2:0003170" + }, { + "val" : "Wikipedia:Anlage_(biology)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007690", "lbl" : "early pharyngeal endoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "comments" : [ "relation conflict: ZFA vs EHDAA2. Note EHDAA2 term renamed to 'early PA endoderm'" ], + "xrefs" : [ { + "val" : "EFO:0003626" + }, { + "val" : "EHDAA2:0001457" + }, { + "val" : "EHDAA:962" + }, { + "val" : "TAO:0001104" + }, { + "val" : "ZFA:0001104" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007719", "lbl" : "bone of reproductive organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a reproductive organ.", + "xrefs" : [ "OBOL:automatic", "https://github.com/obophenotype/uberon/issues/1158" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007771", "lbl" : "epidermis gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a epidermis.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:59153" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007779", "lbl" : "transudate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/transudate" ] + }, + "xrefs" : [ { + "val" : "FMA:12276" + }, { + "val" : "GAID:1195" + }, { + "val" : "MESH:D005122" + }, { + "val" : "ncithesaurus:Transudate" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007794", "lbl" : "secretion of serous gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fluid produced by a serous gland.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Serous_fluid" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007798", "lbl" : "vascular system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Anatomical system that consists of all blood and lymph vessels.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001085" + }, { + "val" : "CALOHA:TS-2053" + }, { + "val" : "EHDAA2:0004520" + }, { + "val" : "EMAPA:35905" + }, { + "val" : "MA:0002718" + }, { + "val" : "NCIT:C33854" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007808", "lbl" : "adipose tissue of abdominal region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots.", + "xrefs" : [ "CALOHA:paula", "MGI:csmith", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/259" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0002" + }, { + "val" : "EFO:0003771" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007811", "lbl" : "craniocervical region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2356" + }, { + "val" : "EV:0100009" + }, { + "val" : "FMA:280881" + }, { + "val" : "MA:0000006" + }, { + "val" : "NCIT:C12418" + }, { + "val" : "SCTID:361355005" + }, { + "val" : "WikipediaCategory:Head_and_neck" + }, { + "val" : "galen:HeadAndNeck" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "lbl" : "post-anal tail", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010338" + }, { + "val" : "MA:0000008" + }, { + "val" : "NCIT:C77663" + }, { + "val" : "TAO:0001117" + }, { + "val" : "XAO:0003026" + }, { + "val" : "ZFA:0001117" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007823", "lbl" : "appendage girdle region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).", + "xrefs" : [ "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:24874" + }, { + "val" : "VSAO:0000303" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0007826", + "lbl" : "peritoneal mesentery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesentery that is located in the peritoneum.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:20570" + }, { + "val" : "TAO:0005129" + }, { + "val" : "XAO:0000138" + }, { + "val" : "ZFA:0005129" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007828", "lbl" : "girdle bone/zone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a appendage girdle region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35379" + }, { + "val" : "MA:0000291" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007829", "lbl" : "pectoral girdle bone", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A bone that is part of a pectoral girdle region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35669" + }, { + "val" : "MA:0000292" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007831", "lbl" : "pectoral girdle skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons.", + "xrefs" : [ "Wikipedia:Pectoral_girdle" ] + }, + "xrefs" : [ { + "val" : "AAO:0000422" + }, { + "val" : "AAO:0000754" + }, { + "val" : "EFO:0000946" + }, { + "val" : "EHDAA2:0001420" + }, { + "val" : "FMA:24141" + }, { + "val" : "MAT:0000181" + }, { + "val" : "MIAA:0000181" + }, { + "val" : "NCIT:C33547" + }, { + "val" : "TAO:0000407" + }, { + "val" : "VHOG:0001156" + }, { + "val" : "VSAO:0000156" + }, { + "val" : "Wikipedia:Pectoral_girdle" + }, { + "val" : "XAO:0003063" + }, { + "val" : "ZFA:0000407" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007842", "lbl" : "membrane bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bone element that arises as a result of intramembranous ossification.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000023", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/267" ] + }, + "xrefs" : [ { + "val" : "AEO:0000085" + }, { + "val" : "EHDAA2:0003085" + }, { + "val" : "TAO:0001645" + }, { + "val" : "VSAO:0000023" + }, { + "val" : "XAO:0004014" + }, { + "val" : "ZFA:0001636" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007844", "lbl" : "cartilage element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal element that is composed of cartilage tissue and may be permanent or transient.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000000", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AAO:0011130" + }, { + "val" : "CALOHA:TS-0118" + }, { + "val" : "FMA:55107" + }, { + "val" : "VSAO:0000000" + }, { + "val" : "XAO:0004013" + }, { + "val" : "ZFA:0001501" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007845", "lbl" : "regular connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue.", + "xrefs" : [ "FMA:20103" ] + }, + "xrefs" : [ { + "val" : "FMA:20103" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007846", "lbl" : "dense regular connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000050", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "FMA:64781" + }, { + "val" : "NCIT:C33453" + }, { + "val" : "SCTID:22560007" + }, { + "val" : "VSAO:0000050" + }, { + "val" : "Wikipedia:Dense_regular_connective_tissue" + }, { + "val" : "XAO:0004030" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0007914", "lbl" : "bone of craniocervical region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a craniocervical region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000569" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008001", + "lbl" : "irregular bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid.", + "xrefs" : [ "Wikipedia:Irregular_bone" ] + }, + "xrefs" : [ { + "val" : "FMA:7477" + }, { + "val" : "NCIT:C32881" + }, { + "val" : "SCTID:421560006" + }, { + "val" : "Wikipedia:Irregular_bone" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008114", "lbl" : "joint of girdle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal joint that is part of a appendage girdle region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001505" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008115", "lbl" : "surface of cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical surface that is part of a cartilage element.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:76668" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008193", + "lbl" : "pneumatized bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD].", + "xrefs" : [ "http://www.medilexicon.com/medicaldictionary.php?t=11303" ] + }, + "xrefs" : [ { + "val" : "FMA:7478" + }, { + "val" : "SCTID:333008005" + }, { + "val" : "Wikipedia:Skeletal_pneumaticity" + }, { + "val" : "galen:PneumaticBone" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008196", "lbl" : "muscle of pectoral girdle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a pectoral girdle region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:37347" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008229", "lbl" : "craniocervical region musculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Musculature system of the pharyngeal and head regions.", + "xrefs" : [ "ZFA:0000328", "ZFA:curator" ] + }, + "xrefs" : [ { + "val" : "MA:0000571" + }, { + "val" : "TAO:0000328" + }, { + "val" : "ZFA:0000328" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008231", "lbl" : "dorsal thoracic segment of trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax.", + "xrefs" : [ "FMA:24217" ] + }, + "xrefs" : [ { + "val" : "FMA:24217" + }, { + "val" : "MA:0000028" + }, { + "val" : "SCTID:362666008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008243", "lbl" : "upper back muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle of back that is part of a dorsal thoracic segment of trunk.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000508" + }, { + "val" : "SCTID:305071003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008307", "lbl" : "heart endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a heart [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004293" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008339", "lbl" : "microvascular endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0003122" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008342", + "lbl" : "intestinal villus of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An intestinal villus in the duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63300" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008346", + "lbl" : "duodenal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2087" + }, { + "val" : "EMAPA:19078" + }, { + "val" : "FMA:17231" + }, { + "val" : "MA:0003208" + }, { + "val" : "SCTID:66036002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008397", "lbl" : "tracheobronchial epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium pertaining to the trachea and bronchi.", + "xrefs" : [ "Dorlands_Medical_Dictionary:MerckMedicus" ] + }, + "xrefs" : [ { + "val" : "BTO:0002925" + }, { + "val" : "CALOHA:TS-1063" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008780", "lbl" : "inner cell mass derived epiblast", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers.", + "xrefs" : [ "MP:0003886" ] + }, + "comments" : [ "The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5." ], + "xrefs" : [ { + "val" : "EHDAA2:0000444" + }, { + "val" : "EHDAA:42" + }, { + "val" : "EHDAA:75" + }, { + "val" : "EMAPA:16050" + }, { + "val" : "NCIT:C34164" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008814", "lbl" : "pharyngeal arch system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified].", + "xrefs" : [ "GO:0060037", "GOC:dph" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000187" + }, { + "val" : "FMA:293041" + }, { + "val" : "NCIT:C34248" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008816", "lbl" : "embryonic head", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A head that is part of a embryo.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0246" + }, { + "val" : "FMA:293011" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008823", "lbl" : "neural tube derived brain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A brain that develops_from a neural tube.", + "xrefs" : [ "OBOL:automatic", "https://github.com/obophenotype/uberon/issues/338" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008826", "lbl" : "pulmonary surfactant", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein).", + "xrefs" : [ "Wikipedia:Pulmonary_surfactant" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36551" + }, { + "val" : "FMA:62780" + }, { + "val" : "MA:0002534" + }, { + "val" : "NCIT:C13273" + }, { + "val" : "Wikipedia:Pulmonary_surfactant" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "lbl" : "hepatic diverticulum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts.", + "xrefs" : [ "MP:MP", "http://www.stembook.org/node/512" ] + }, + "xrefs" : [ { + "val" : "AAO:0011057" + }, { + "val" : "EHDAA2:0000740" + }, { + "val" : "EHDAA:1530" + }, { + "val" : "NCIT:C34187" + }, { + "val" : "Wikipedia:Hepatic_diverticulum" + }, { + "val" : "XAO:0000101" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "lbl" : "liver bud", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0001642" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008851", "lbl" : "ectoplacental cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals.", + "xrefs" : [ "MP:0011207", "http://www.medilexicon.com/medicaldictionary.php?s=epamniotic+cavity" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16080" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "lbl" : "stomach muscularis externa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines.", + "xrefs" : [ "MP:0010779" ] + }, + "xrefs" : [ { + "val" : "FMA:14909" + }, { + "val" : "SCTID:362132003" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "lbl" : "pyloric canal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter.", + "xrefs" : [ "MP:0010791", "Wikipedia:Pyloric_canal" ] + }, + "xrefs" : [ { + "val" : "FMA:14580" + }, { + "val" : "SCTID:245417002" + }, { + "val" : "Wikipedia:Pyloric_canal" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "lbl" : "pyloric gastric gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP].", + "xrefs" : [ "MP:0010797", "Wikipedia:Pyloric_gland" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27211" + }, { + "val" : "FMA:14922" + }, { + "val" : "NCIT:C33431" + }, { + "val" : "SCTID:70710007" + }, { + "val" : "Wikipedia:Pyloric_gland" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008870", "lbl" : "pulmonary alveolar parenchyma", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages.", + "xrefs" : [ "MP:0010901" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008874", "lbl" : "pulmonary acinus", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The largest lung subunit in which all airways participate in gas exchange, and it is composed of the parenchyma of the respiratory bronchioles, alveolar ducts, and alveoli.", + "xrefs" : [ "MP:0010911", "PMID:2014492", "PMID:3382030", "Wikipedia:Acinus#The_Lungs" ] + }, + "xrefs" : [ { + "val" : "FMA:7313" + }, { + "val" : "NCIT:C33426" + }, { + "val" : "SCTID:361365004" + }, { + "val" : "Wikipedia:Acinus#The_Lungs" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008876", "lbl" : "hypodermis skeletal muscle layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any skeletal muscle organ in the hypodermis / superficial fascia.", + "xrefs" : [ "ISBN:0123813611", "MP:0011157" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18188" + }, { + "val" : "MA:0003140" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008886", "lbl" : "pulmonary vascular system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Pulmonary_circulation" ] + }, + "xrefs" : [ { + "val" : "FMA:45621" + }, { + "val" : "Wikipedia:Pulmonary_circulation" } ] } }, { @@ -21789,435 +77244,2026 @@ "lbl" : "splanchnocranium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Subdivision of endoskeleton derived from pharyngeal arches.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Facial_skeleton", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010157" + }, { + "val" : "TAO:0001216" + }, { + "val" : "VHOG:0000315" + }, { + "val" : "VSAO:0000149" + }, { + "val" : "Wikipedia:Facial_skeleton" + }, { + "val" : "XAO:0003176" + }, { + "val" : "ZFA:0001216" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008907", "lbl" : "dermal bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO].", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000130", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/267" ] + }, + "xrefs" : [ { + "val" : "AAO:0010769" + }, { + "val" : "TAO:0001590" + }, { + "val" : "VSAO:0000130" + }, { + "val" : "Wikipedia:Dermal_bone" + }, { + "val" : "XAO:0004015" + }, { + "val" : "ZFA:0001590" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008909", "lbl" : "perichordal bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bone element that is adjacent to the notochord.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000307", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AAO:0010777" + }, { + "val" : "TAO:0001639" + }, { + "val" : "VSAO:0000307" + }, { + "val" : "ZFA:0001629" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008946", "lbl" : "lung parenchyma", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A parenchyma that is part of a lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35522" + }, { + "val" : "FMA:27360" + }, { + "val" : "MA:0003168" + }, { + "val" : "SCTID:201712001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008947", "lbl" : "respiratory primordium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004069" + }, { + "val" : "NCIT:C34283" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008951", "lbl" : "left lung lobe", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lobe of lung that is part of a left lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA:2981" + }, { + "val" : "NCIT:C48945" + }, { + "val" : "SCTID:272655003" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "lbl" : "submucosal esophageal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed.", + "xrefs" : [ "BTO:0003634", "Wikipedia:Esophageal_glands" ] + }, + "xrefs" : [ { + "val" : "BTO:0003634" + }, { + "val" : "FMA:9404" + }, { + "val" : "NCIT:C32536" + }, { + "val" : "SCTID:322749003" + }, { + "val" : "Wikipedia:Esophageal_glands" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0008998", "lbl" : "vasculature of brain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "System pertaining to blood vessels in the brain.", + "xrefs" : [ "BTO:0003840" ] + }, + "xrefs" : [ { + "val" : "BTO:0003840" + }, { + "val" : "EFO:0003491" + }, { + "val" : "EMAPA:35186" + }, { + "val" : "FMA:242007" + }, { + "val" : "FMA:61935" + }, { + "val" : "SCTID:362029003" + }, { + "val" : "TAO:0000099" + }, { + "val" : "ZFA:0000099" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009015", "lbl" : "upper back skin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a dorsal thoracic segment of trunk.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000510" + }, { + "val" : "SCTID:304890003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009030", "lbl" : "left pulmonary vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vein that drains left lung and returns blood to the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0002207" + }, { + "val" : "NCIT:C48946" + }, { + "val" : "SCTID:304057004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009032", "lbl" : "right pulmonary vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vein that drains right lung and returns blood to the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0002208" + }, { + "val" : "NCIT:C48947" + }, { + "val" : "SCTID:304056008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009117", "lbl" : "indifferent gonad", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gonad prior to differentiating into a definitive testis or ovary.", + "xrefs" : [ "http://www.medterms.com/script/main/art.asp?articlekey=8981" ] + }, + "comments" : [ "typically part of the embryo - however, in male tammar wallabies the gonads are indifferent at the neonatal stage[8827321]" ], + "xrefs" : [ { + "val" : "EHDAA2:0000716" + }, { + "val" : "NCIT:C34192" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009127", "lbl" : "epibranchial ganglion", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Cranial ganglion which develops from an epibranchial placode.", + "xrefs" : [ "PMID:20133851", "ZFIN:curator" ] + }, + "comments" : [ "Epibranchial ganglia orchestrate the development of the cranial neurogenic crest" ], + "xrefs" : [ { + "val" : "TAO:0001555" + }, { + "val" : "ZFA:0001555" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009129", "lbl" : "right atrium endocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endocardium that is part of the right atrium.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000274" + }, { + "val" : "FMA:7281" + }, { + "val" : "NCIT:C102339" + }, { + "val" : "SCTID:3194006" + }, { + "val" : "VHOG:0001228" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009133", "lbl" : "pleuroperitoneal membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities.", + "xrefs" : [ "Wikipedia:Pleuroperitoneal", "http://medical-dictionary.thefreedictionary.com/pleuroperitoneal+membrane" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001483" + }, { + "val" : "EMAPA:17709" + }, { + "val" : "NCIT:C34256" + }, { + "val" : "SCTID:361429005" + }, { + "val" : "VHOG:0000757" + }, { + "val" : "Wikipedia:Pleuroperitoneal" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009141", "lbl" : "craniocervical region vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a craniocervical region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004542" + }, { + "val" : "SCTID:32945007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009142", "lbl" : "entire embryonic mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Sum total of mesenchyme in the embryo.", + "xrefs" : [ "https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/7" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001113" + }, { + "val" : "EHDAA:177" + }, { + "val" : "EMAPA:16097" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009145", "lbl" : "pharyngeal region of foregut", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:16549" + }, { + "val" : "RETIRED_EHDAA2:0001454" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "lbl" : "sphenoid bone pre-cartilage condensation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0003446" + }, { + "val" : "EMAPA:18015" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "lbl" : "sphenoid cartilage element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphenoid endochondral element that is composed primarily of cartilage tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001888" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009196", "lbl" : "indifferent external genitalia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004021" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009204", + "lbl" : "medial nasal process mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a medial nasal prominence.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001077" + }, { + "val" : "EMAPA:16810" + }, { + "val" : "FMA:312659" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009292", + "lbl" : "embryonic nasal process", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000581" + }, { + "val" : "EHDAA:4776" + }, { + "val" : "EMAPA:16680" + }, { + "val" : "SCTID:308881001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009479", "lbl" : "ectoderm of buccopharyngeal membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An ectoderm that is part of a buccopharyngeal membrane.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000190" + }, { + "val" : "EMAPA:16260" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009480", "lbl" : "endoderm of buccopharyngeal membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endoderm that is part of a buccopharyngeal membrane.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000191" + }, { + "val" : "EMAPA:16261" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009482", + "lbl" : "associated mesenchyme of foregut-midgut junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a foregut-midgut junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000570" + }, { + "val" : "EMAPA:16364" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009483", + "lbl" : "mesentery of foregut-midgut junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesentery that is part of a foregut-midgut junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000575" + }, { + "val" : "EMAPA:16365" + }, { + "val" : "VHOG:0000430" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009494", + "lbl" : "pharyngeal arch mesenchymal region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of mesenchymal tissue associated with an individual pharyngeal arch.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32755" + }, { + "val" : "FMA:295694" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "lbl" : "epithelium of foregut-midgut junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a foregut-midgut junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000573" + }, { + "val" : "EMAPA:16564" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009501", + "lbl" : "mesenchyme of fronto-nasal process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head.", + "xrefs" : [ "MP:0011266" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004109" + }, { + "val" : "EMAPA:16683" + }, { + "val" : "FMA:295821" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009503", + "lbl" : "mesenchyme of hindgut", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing hindgut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000780" + }, { + "val" : "EMAPA:16716" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009505", + "lbl" : "mesenchyme of trachea", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002067" + }, { + "val" : "EMAPA:16854" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009521", + "lbl" : "anal membrane endodermal component", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endoderm that is part of a anal region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004020" + }, { + "val" : "EMAPA:17177" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009526", + "lbl" : "maxillary process mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a maxillary prominence.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001071" + }, { + "val" : "EMAPA:17361" + }, { + "val" : "FMA:312691" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009548", + "lbl" : "hepatic sinusoid of left of lobe of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic sinusoid that is part of a left lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001001" + }, { + "val" : "EMAPA:18309" + }, { + "val" : "VHOG:0000709" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009549", + "lbl" : "hepatic sinusoid of right of lobe of liver", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic sinusoid that is part of a right lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001009" + }, { + "val" : "EMAPA:18316" + }, { + "val" : "VHOG:0000710" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009550", + "lbl" : "endoderm of foregut-midgut junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endoderm that is part of a foregut-midgut junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000572" + }, { + "val" : "EMAPA:18403" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0009494", - "lbl" : "pharyngeal arch mesenchymal region", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0009566", + "lbl" : "intestinal submucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a intestine.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15696" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0009505", - "lbl" : "mesenchyme of trachea", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0009568", + "lbl" : "trunk region of vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions.", + "xrefs" : [ "UBERONREF:0000006" ] + }, + "xrefs" : [ { + "val" : "FMA:72066" + }, { + "val" : "NCIT:C92597" + }, { + "val" : "SCTID:281699004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009569", "lbl" : "subdivision of trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:25054" + }, { + "val" : "SCTID:22943007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009570", "lbl" : "spinal cord sulcus limitans", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sulcus limitans of neural tube that is part of a future spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001265" + }, { + "val" : "EMAPA:17584" + }, { + "val" : "VHOG:0001548" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009576", "lbl" : "medulla oblongata sulcus limitans", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sulcus limitans of neural tube that is part of a future medulla oblongata.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001100" + }, { + "val" : "EMAPA:17561" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009577", "lbl" : "metencephalon sulcus limitans", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sulcus limitans of neural tube that is part of a future metencephalon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001161" + }, { + "val" : "EMAPA:17567" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009578", "lbl" : "myelencephalon sulcus limitans", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sulcus limitans of neural tube that is part of a future myelencephalon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001945" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009581", "lbl" : "midbrain mantle layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001172" + }, { + "val" : "EMAPA:16977" + }, { + "val" : "VHOG:0000910" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009583", "lbl" : "spinal cord mantle layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:17580" + }, { + "val" : "VHOG:0000911" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009584", "lbl" : "1st arch mandibular mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a 1st arch mandibular component.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000034" + }, { + "val" : "EMAPA:16385" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009602", "lbl" : "left lung associated mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing left lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000944" + }, { + "val" : "EMAPA:16730" + }, { + "val" : "EMAPA:17654" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009603", "lbl" : "right lung associated mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing right lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001739" + }, { + "val" : "EMAPA:17662" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009611", "lbl" : "midbrain neural plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural plate that develops_from a presumptive midbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0007019" + }, { + "val" : "ZFA:0007019" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009614", "lbl" : "hindbrain neural plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural plate that develops_from a presumptive hindbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0007022" + }, { + "val" : "ZFA:0007022" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009615", "lbl" : "midbrain hindbrain boundary neural plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "TAO:0007044" + }, { + "val" : "ZFA:0007044" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009616", "lbl" : "presumptive midbrain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A presumptive structure that has the potential to develop into a midbrain.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BAMS:MES" + }, { + "val" : "EFO:0003432" + }, { + "val" : "EHDAA2:0000615" + }, { + "val" : "EMAPA:16140" + }, { + "val" : "TAO:0000148" + }, { + "val" : "Wikipedia:Mesencephalon" + }, { + "val" : "ZFA:0000148" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009617", "lbl" : "head paraxial mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles.", + "xrefs" : [ "PMID:21610022" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000736" + }, { + "val" : "EHDAA:364" + }, { + "val" : "EMAPA:16171" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009618", "lbl" : "trunk paraxial mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0002094" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009621", + "lbl" : "tail somite", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A somite that is part of a tail.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0010383" + }, { + "val" : "EMAPA:16860" + }, { + "val" : "XAO:0003143" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009644", "lbl" : "trachea non-cartilage connective tissue", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "EMAPA:35878" + }, { + "val" : "MA:0001859" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009652", "lbl" : "bronchus basement membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A basement membrane that is part of a bronchus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001832" + }, { + "val" : "NCIT:C49208" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009653", "lbl" : "trachea basement membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A basement membrane that is part of a trachea.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001854" + }, { + "val" : "NCIT:C49302" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009657", "lbl" : "artery of lip", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "MA:0001987" + }, { + "val" : "NCIT:C52947" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009661", "lbl" : "midbrain nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Nucleus located in the midbrain.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "SCTID:279285003" + }, { + "val" : "TAO:0002209" + }, { + "val" : "ZFA:0001665" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009662", "lbl" : "hindbrain nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Nucleus located within the hindbrain.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "TAO:0002177" + }, { + "val" : "ZFA:0001658" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009664", + "lbl" : "gut mesentery", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004566" + }, { + "val" : "EMAPA:32911" + }, { + "val" : "MA:0003203" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "lbl" : "embryonic cloacal lumen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that surrounded_by a embryonic cloaca.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004586" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "lbl" : "rectal lumen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that surrounded_by a rectum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004587" + }, { + "val" : "EMAPA:18388" + }, { + "val" : "FMA:14598" + }, { + "val" : "SCTID:259740004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "lbl" : "dorsal pancreas", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001371" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "lbl" : "ventral pancreas", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001393" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009712", "lbl" : "endocardium of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any endocardium that is part of the right ventricle of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002188" + }, { + "val" : "EMAPA:17341" + }, { + "val" : "FMA:9536" + }, { + "val" : "NCIT:C102343" + }, { + "val" : "SCTID:8911002" + }, { + "val" : "VHOG:0001235" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009713", "lbl" : "endocardium of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any endocardium that is part of the left ventricle of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002182" + }, { + "val" : "EMAPA:17338" + }, { + "val" : "FMA:9559" + }, { + "val" : "SCTID:191004004" + }, { + "val" : "VHOG:0001233" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009715", "lbl" : "stomodeal lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a stomodeum.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009722", "lbl" : "entire pharyngeal arch endoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004621" + }, { + "val" : "EMAPA:32754" + }, { + "val" : "FMA:293087" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009751", "lbl" : "cardiac mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures.", + "xrefs" : [ "MP:0011264" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004162" + }, { + "val" : "EMAPA:36438" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009752", + "lbl" : "pancreas mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas.", + "xrefs" : [ "MP:0011265" ] + }, + "xrefs" : [ { + "val" : "EFO:0002557" + }, { + "val" : "EMAPA:26220" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009758", "lbl" : "abdominal ganglion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A ganglion that is part of a abdominal segment of trunk.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:280508003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009778", "lbl" : "pleural sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous sac that has the pleura and the pleural cavity as parts.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004737" + }, { + "val" : "FMA:9690" + }, { + "val" : "SCTID:361996004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009842", "lbl" : "glandular acinus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form.", + "xrefs" : [ "Wikipedia:Acinus" ] + }, + "xrefs" : [ { + "val" : "FMA:55588" + }, { + "val" : "Wikipedia:Acinus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "lbl" : "embryonic cloacal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a embryonic cloaca.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004585" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009854", "lbl" : "digestive tract diverticulum", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Branch or outpocketing of the digestive tract.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009856", "lbl" : "sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "galen:Diverticulum" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009870", "lbl" : "zone of stomach", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Stomach#Sections" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35821" + }, { + "val" : "FMA:14558" + }, { + "val" : "MA:0002561" + }, { + "val" : "SCTID:245415005" + }, { + "val" : "Wikipedia:Stomach#Sections" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009881", "lbl" : "anterior lateral plate mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EFO:0003704" + }, { + "val" : "TAO:0005041" + }, { + "val" : "ZFA:0005041" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009889", "lbl" : "secondary heart field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).", + "xrefs" : [ "GO:0003139", "GOC:mtg_heart", "GOC:rl" ] + }, + "xrefs" : [ { + "val" : "XAO:0004186" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009891", "lbl" : "facial mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing face.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35337" + }, { + "val" : "FMA:302884" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009911", "lbl" : "lobule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:45737" + }, { + "val" : "NCIT:C12990" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009912", "lbl" : "anatomical lobe", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of an organ, such as the liver, lung, breast, or brain.", + "xrefs" : [ "ncithesaurus:Lobe" ] + }, + "xrefs" : [ { + "val" : "FMA:45728" + }, { + "val" : "NCIT:C13393" + }, { + "val" : "UMLS:C0796494" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009920", "lbl" : "optic neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001315" + }, { + "val" : "EHDAA:1122" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009953", "lbl" : "post-embryonic organism", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multicellular organism that existence_starts_with a post-embryonic stage.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0002405" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0009955", "lbl" : "neurogenic placode", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia.", + "xrefs" : [ "PMID:11523831", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EFO:0003460" + }, { + "val" : "TAO:0001309" + }, { + "val" : "Wikipedia:Neurogenic_placodes" + }, { + "val" : "XAO:0004620" + }, { + "val" : "ZFA:0001309" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "lbl" : "epithelium of pancreatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a pancreatic duct.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0002556" + }, { + "val" : "FMA:67681" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010000", "lbl" : "multicellular anatomical structure", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "An anatomical structure that has more than one cell as a part.", + "xrefs" : [ "CARO:0010000" ] + }, + "xrefs" : [ { + "val" : "CARO:0010000" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010009", "lbl" : "aggregate regional part of brain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF].", + "xrefs" : [ "NLXANAT:20090509" ] + }, + "xrefs" : [ { + "val" : "NLXANAT:20090509" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010031", "lbl" : "6th arch mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a pharyngeal arch 6.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004076" + }, { + "val" : "EMAPA:32765" + }, { + "val" : "FMA:318209" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010039", "lbl" : "food storage organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ of the digestive tract that is capable of retaining and storing food.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BSA:0000123" + }, { + "val" : "TADS:0000172" + }, { + "val" : "TGMA:0001041" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010042", "lbl" : "1st arch mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a pharyngeal arch 1.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16128" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010045", + "lbl" : "1st arch maxillary mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a 1st arch maxillary component.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000041" + }, { + "val" : "EMAPA:16391" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010046", "lbl" : "entire pharyngeal arch associated mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells.", + "xrefs" : [ "XAO:0004524", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001459" + }, { + "val" : "EMAPA:16550" + }, { + "val" : "XAO:0004524" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010047", "lbl" : "oral gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Gland of the epithelium lining the oral cavity. The most common are the salivary glands.", + "xrefs" : [ "ISBN:0073040584" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001327" + }, { + "val" : "EHDAA:2181" + }, { + "val" : "EMAPA:16572" + }, { + "val" : "EMAPA:16723" + }, { + "val" : "VHOG:0000652" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010077", "lbl" : "cuboidal epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium consisting of cuboidal epithelial cells.", + "xrefs" : [ "Wikipedia:Cuboidal_epithelium" ] + }, + "xrefs" : [ { + "val" : "NCIT:C32415" + }, { + "val" : "Wikipedia:Cuboidal_epithelium" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "lbl" : "future common hepatic duct", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An extrahepatic bile duct that has the potential to develop into a common hepatic duct.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000595" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010083", "lbl" : "future dermis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that has the potential to develop into a dermis.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000598" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010084", "lbl" : "future diaphragm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A structure that will develop into a diaphragm.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000599" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010092", "lbl" : "future metencephalon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developing anatomical structure that has the potential to develop into a metencephalon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000623" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010096", "lbl" : "future myelencephalon", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A developing anatomical structure that has the potential to develop into a myelencephalon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000640" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010125", "lbl" : "future superior salivatory nucleus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gray matter that has the potential to develop into a superior salivatory nucleus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004644" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010131", "lbl" : "conducting tissue of heart", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004528" + }, { + "val" : "FMA:83378" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010136", "lbl" : "epithelial sheet", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelial sheet is a flat surface consisting of closely packed epithelial cells.", + "xrefs" : [ "GO:0002011" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010152", + "lbl" : "skin mucus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucous secretion that is produced by glands in the epidermis.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010161", "lbl" : "lumen of blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that surrounded_by a blood vessel.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:312610" + }, { + "val" : "SCTID:91747007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010162", + "lbl" : "post-anal tail tip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The distal end of the tail.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MA:0002848" + }, { + "val" : "XAO:0004057" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010183", + "lbl" : "liver trabecula", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A trabecula that is part of a liver.", + "xrefs" : [ "GO:0060344", "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010188", "lbl" : "protuberance", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A roughly circular bulge in a surface.", + "xrefs" : [ "EHDAA2:0003250" ] + }, + "xrefs" : [ { + "val" : "AEO:0000205" + }, { + "val" : "EHDAA2:0003250" + }, { + "val" : "FMA:82506" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010191", "lbl" : "aortic system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004512" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010192", "lbl" : "genital artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the laterally paired arteries that supply the gonads.", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Gonadal_artery" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Gonadal_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010194", + "lbl" : "hepatic portal system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver.", + "xrefs" : [ "ISBN:0073040584" ] + }, + "xrefs" : [ { + "val" : "AAO:0010225" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010199", "lbl" : "bona-fide anatomical boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical boundary that corresponds to some physical discontinuity.", + "xrefs" : [ "CARO:0001004" ] + }, + "comments" : [ "One might argue that all boundaries are actually fiat in the sense that there must be some fiat element at a fine enough scale of granularity. This ontology choses to ignore this issue as below the level of granularity relevant to anatomy. (DOS121102)" ], + "xrefs" : [ { + "val" : "CARO:0001004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010204", + "lbl" : "tail vasculature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vasculature that is part of a post-anal tail.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005037" + }, { + "val" : "XAO:0004151" + }, { + "val" : "ZFA:0005037" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010227", "lbl" : "future cardiac atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Multi-tissue structure that is part of the heart tube and will become the cardiac atrium.", + "xrefs" : [ "ZFA:0001718" ] + }, + "xrefs" : [ { + "val" : "FMA:71005" + }, { + "val" : "TAO:0002228" + }, { + "val" : "ZFA:0001718" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010230", "lbl" : "eyeball of camera-type eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The core globe-shaped component of the camera-type eye.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:12513" + }, { + "val" : "MIAA:0000283" + }, { + "val" : "SCTID:244486005" + }, { + "val" : "VHOG:0001616" + }, { + "val" : "Wikipedia:Globe_(human_eye)" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010243", "lbl" : "merocrine gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged.", + "xrefs" : [ "MGI:anna", "MP:0013544", "Wikipedia:Merocrine" ] + }, + "xrefs" : [ { + "val" : "BTO:0002324" + }, { + "val" : "MA:0003041" + }, { + "val" : "Wikipedia:Merocrine" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010252", "lbl" : "1st arch mandibular mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000037" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "lbl" : "1st arch maxillary mesenchyme from neural crest", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000044" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010256", "lbl" : "4th arch mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000098" + }, { + "val" : "EMAPA:16772" + }, { + "val" : "VHOG:0000580" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010257", "lbl" : "6th arch mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004077" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010258", "lbl" : "mesenchyme from rhombencephalic neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a rhombencephalon neural crest.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004423" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010259", "lbl" : "1st arch mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16129" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010276", + "lbl" : "space in vertebral column", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any anatomical space that is part of a vertebral column.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000700" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010285", "lbl" : "midbrain basal plate", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of tissue that is dorsolateral to the floor plate and part of the midbrain.", + "xrefs" : [ "ZFA:0000761" ] + }, + "xrefs" : [ { + "val" : "DHBA:12322" + }, { + "val" : "EFO:0003567" + }, { + "val" : "EHDAA2:0004375" + }, { + "val" : "TAO:0000761" + }, { + "val" : "ZFA:0000761" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010286", "lbl" : "midbrain neural tube", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Portion of neural tube that gives rise to the midbrain.", + "xrefs" : [ "ZFA:0007039" ] + }, + "xrefs" : [ { + "val" : "TAO:0007039" + }, { + "val" : "ZFA:0007039" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010291", "lbl" : "layer of sclera", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "Wikipedia:Sclera#Histology" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010294", "lbl" : "scleral endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An endothelium that is part of a sclera.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010295", "lbl" : "substantia propria of sclera", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stroma that is part of a sclera.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:58365" + }, { + "val" : "NCIT:C33652" + }, { + "val" : "SCTID:368851004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010299", "lbl" : "scleral mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme surrounding the developing optic cup which develops into the sclera.", + "xrefs" : [ "PMID:16496288", "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010303", "lbl" : "extraembryonic epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a extraembryonic structure.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010312", "lbl" : "immature eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Developing anatomical structure that develops into the eyeball and associated structures.", + "xrefs" : [ "ZFA:0001678" ] + }, + "xrefs" : [ { + "val" : "TAO:0002201" + }, { + "val" : "ZFA:0001678" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010313", "lbl" : "neural crest-derived structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that develops from the neural crest.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010314", "lbl" : "structure with developmental contribution from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical structure that has some part that develops from the neural crest.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010316", "lbl" : "germ layer / neural crest", @@ -22225,177 +79271,826 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010321", "lbl" : "skeletal element of eye region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal element that is part of a orbital region.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010323", "lbl" : "cranial skeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000049", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "AAO:0000109" + }, { + "val" : "AAO:0000971" + }, { + "val" : "AAO:0010185" + }, { + "val" : "TAO:0000737" + }, { + "val" : "VSAO:0000049" + }, { + "val" : "XAO:0003075" + }, { + "val" : "ZFA:0000737" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010329", "lbl" : "paired limb/fin bud mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a limb/fin bud.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010333", "lbl" : "extraembryonic membrane mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a extraembryonic membrane.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "lbl" : "maxillary process mesenchyme from neural crest", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004601" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "lbl" : "maxillary process mesenchyme from head mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004602" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010336", "lbl" : "mandibular process mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004603" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010337", "lbl" : "mandibular process mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004604" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010338", + "lbl" : "1st arch maxillary mesenchyme from head mesenchyme", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000043" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010339", "lbl" : "1st arch mandibular mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000036" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010341", "lbl" : "1st arch mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16130" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010345", "lbl" : "4th arch mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000097" + }, { + "val" : "EMAPA:16771" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010347", "lbl" : "6th arch mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004078" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010359", "lbl" : "pharyngeal arch mesenchyme from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme" ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010360", "lbl" : "pharyngeal arch mesenchyme from head mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme" ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010362", "lbl" : "endoskeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000037", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000037" + }, { + "val" : "Wikipedia:Endoskeleton" + }, { + "val" : "XAO:0004026" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010363", "lbl" : "endochondral element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000139", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000139" + }, { + "val" : "XAO:0004017" + }, { + "val" : "ZFA:0005620" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010364", "lbl" : "dermal skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000035", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "comments" : [ "This ontology covers metazoa, so we do not use exoskeleton as primary label, as in VSAO" ], + "xrefs" : [ { + "val" : "VSAO:0000035" + }, { + "val" : "XAO:0004025" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010368", "lbl" : "pulmonary lobule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa.", + "xrefs" : [ "ncithesaurus:Pulmonary_Lobule" ] + }, + "xrefs" : [ { + "val" : "FMA:75739" + }, { + "val" : "NCIT:C33428" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010369", "lbl" : "secondary pulmonary lobule", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa.", + "xrefs" : [ "PMID:3259815" ] + }, + "xrefs" : [ { + "val" : "FMA:7414" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010371", "lbl" : "ecto-epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium composed of cells that develops from the ectoderm[FMA,modified].", + "xrefs" : [ "FMA:69064" ] + }, + "xrefs" : [ { + "val" : "FMA:69064" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "lbl" : "pancreas dorsal primordium", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001384" + }, { + "val" : "FMA:79793" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "lbl" : "pancreas ventral primordium", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001387" + }, { + "val" : "FMA:79794" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010377", "lbl" : "mesenchyme from somatopleure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a somatopleure.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001120" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010378", "lbl" : "mesenchyme from splanchnopleure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from a splanchnopleure.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0001122" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "lbl" : "spleen trabecular artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the branches of the splenic artery[MP].", + "xrefs" : [ "MP:0002354", "Wikipedia:Trabecular_arteries" ] + }, + "xrefs" : [ { + "val" : "MA:0000759" + }, { + "val" : "NCIT:C49775" + }, { + "val" : "Wikipedia:Trabecular_arteries" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "lbl" : "spleen trabecular vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the veins that feed the splenic vein.", + "xrefs" : [ "MP:0002228", "Wikipedia:Trabecular_veins" ] + }, + "xrefs" : [ { + "val" : "MA:0000760" + }, { + "val" : "NCIT:C49779" + }, { + "val" : "Wikipedia:Trabecular_veins" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010409", "lbl" : "ocular surface region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms.", + "xrefs" : [ "MP:0013754" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35336" + }, { + "val" : "MA:0002486" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010427", "lbl" : "ciliary processes", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens.", + "xrefs" : [ "Wikipedia:Ciliary_processes" ] + }, + "xrefs" : [ { + "val" : "FMA:76551" + }, { + "val" : "SCTID:280860001" + }, { + "val" : "Wikipedia:Ciliary_processes" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010428", "lbl" : "flat bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow.", + "xrefs" : [ "Wikipedia:Flat_bone" ] + }, + "comments" : [ "Examples: cranium, the ilium, sternum, rib cage, the sacrum and the scapula; the occipital, parietal, frontal, nasal, lacrimal, vomer, scapula, os coxC&, sternum, and ribs" ], + "xrefs" : [ { + "val" : "FMA:7476" + }, { + "val" : "NCIT:C32616" + }, { + "val" : "SCTID:332907008" + }, { + "val" : "Wikipedia:Flat_bone" + }, { + "val" : "galen:FlatBone" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010498", "lbl" : "pseudostratified columnar epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels.", + "xrefs" : [ "Wikipedia:Pseudostratified_columnar_epithelium", "http://medical-dictionary.thefreedictionary.com/pseudostratified+epithelium" ] + }, + "xrefs" : [ { + "val" : "FMA:45572" + }, { + "val" : "NCIT:C33419" + }, { + "val" : "NCIT:C49316" + }, { + "val" : "Wikipedia:Pseudostratified_columnar_epithelium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010499", "lbl" : "pseudostratified ciliated columnar epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile.", + "xrefs" : [ "NCIT:NCIT" ] + }, + "xrefs" : [ { + "val" : "FMA:13146" + }, { + "val" : "NCIT:C13181" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010522", "lbl" : "replacement element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal element that forms as a replacement or substitution of another element or tissue.", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000135", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000135" + }, { + "val" : "XAO:0004016" + }, { + "val" : "ZFA:0005624" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010523", + "lbl" : "microcirculatory vessel", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses.", + "xrefs" : [ "MESH:A07.231.432", "ZFA:0005251", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "MESH:D055806" + }, { + "val" : "TAO:0005251" + }, { + "val" : "ZFA:0005251" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010527", + "lbl" : "cavity of bone organ", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ cavity that surrounded_by a bone.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:24021" + } ] + } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0010523", - "lbl" : "microcirculatory vessel", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0010528", + "lbl" : "pneumatic cavity of bone", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:24028" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010707", "lbl" : "appendage girdle complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).", + "xrefs" : [ "https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7182" + }, { + "val" : "VSAO:0000214" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010708", "lbl" : "pectoral complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle.", + "xrefs" : [ "VSAO:0000213" ] + }, + "xrefs" : [ { + "val" : "FMA:7183" + }, { + "val" : "SCTID:110716002" + }, { + "val" : "VSAO:0000213" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010719", "lbl" : "girdle skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The subdivision of the skeleton of either the pectoral or pelvic girdle.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010686" + }, { + "val" : "VSAO:0000302" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010740", "lbl" : "bone of appendage girdle complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle).", + "xrefs" : [ "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35494" + }, { + "val" : "MA:0000688" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010741", "lbl" : "bone of pectoral complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin.", + "xrefs" : [ "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35933" + }, { + "val" : "MA:0000612" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010891", "lbl" : "pectoral complex muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle of a pectoral girdle, pectoral fin or anterior limb.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0010687" + }, { + "val" : "EMAPA:32624" + }, { + "val" : "FMA:9621" + }, { + "val" : "MA:0000615" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010912", "lbl" : "subdivision of skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.", + "xrefs" : [ "UBERONREF:0000003", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:23879" + }, { + "val" : "SCTID:129140006" + }, { + "val" : "VSAO:0000042" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0010913", + "lbl" : "vertebral element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Skeletal element that forms around the notochord and is part of the vertebral column.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "https://github.com/obophenotype/uberon/issues/294" ] + }, + "xrefs" : [ { + "val" : "VHOG:0001143" + }, { + "val" : "VSAO:0000184" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0010959", "lbl" : "craniocervical muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of either the head or the neck.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "NCIT:C32716" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011004", "lbl" : "pharyngeal arch cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cartilage element that is part of a splanchnocranium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0003689" + }, { + "val" : "TAO:0001460" + }, { + "val" : "ZFA:0001460" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "lbl" : "palatoquadrate arch", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG].", + "xrefs" : [ "VHOG:0000511", "https://github.com/obophenotype/uberon/issues/153" ] + }, + "xrefs" : [ { + "val" : "EFO:0003659" + }, { + "val" : "TAO:0001272" + }, { + "val" : "ZFA:0001272" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "lbl" : "vertebra cartilage element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32669" + }, { + "val" : "VHOG:0000584" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011095", + "lbl" : "vertebra pre-cartilage condensation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.", + "xrefs" : [ "GO_REF:0000034", "VSAO:0000184", "http://dx.plos.org/10.1371/journal.pone.0051070", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32671" + }, { + "val" : "VHOG:0000582" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011108", "lbl" : "synovial joint of pectoral girdle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A synovial joint that is part of a pectoral girdle region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:35243" + }, { + "val" : "SCTID:303080001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011134", "lbl" : "nonsynovial joint", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis.", + "xrefs" : [ "FMA:7491" ] + }, + "xrefs" : [ { + "val" : "FMA:7491" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011137", "lbl" : "axial skeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7483" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011138", "lbl" : "postcranial axial skeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/44", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:302077" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011148", + "lbl" : "submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue.", + "xrefs" : [ "BTO:0003751", "Wikipedia:Submucosal_glands" ] + }, + "xrefs" : [ { + "val" : "BTO:0003751" + }, { + "val" : "Wikipedia:Submucosal_glands" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011156", "lbl" : "facial skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of skull that consists of the facial bones.", + "xrefs" : [ "MP:0005274", "Wikipedia:Facial_skeleton", "http://www.bartleby.com/107/37.html", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002206" + }, { + "val" : "EHDAA:8361" + }, { + "val" : "EMAPA:18022" + }, { + "val" : "FMA:53673" + }, { + "val" : "MA:0000318" + }, { + "val" : "Wikipedia:Facial_skeleton" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011158", "lbl" : "primary subdivision of skull", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The skull can be divided into two: the neurocranium and the facial skeleton.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:54964" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011159", "lbl" : "primary subdivision of cranial skeletal system", @@ -22403,346 +80098,1601 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011164", "lbl" : "neurocranium bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone that is part of a neurocranium [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35238" + }, { + "val" : "MA:0001478" + }, { + "val" : "SCTID:120229002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011171", + "lbl" : "joint connecting upper and lower jaws", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Synovial joint that articulates bones of upper and lower jaw.", + "xrefs" : [ "http://evolution.berkeley.edu/evolibrary/article/evograms_05", "https://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011185", + "lbl" : "gastrointestinal sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphincter muscle that is part of the gastrointestinal system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "NCIT:C32669" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011189", + "lbl" : "lamina propria of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a large intestine.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15654" + }, { + "val" : "NCIT:C49298" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011198", + "lbl" : "muscle layer of large intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of a large intestine.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14971" + }, { + "val" : "NCIT:C32927" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011201", + "lbl" : "muscle layer of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of a small intestine.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14932" + }, { + "val" : "NCIT:C33569" + }, { + "val" : "SCTID:362145004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011215", "lbl" : "central nervous system cell part cluster", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A multi cell part structure that is part of a central nervous system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:83143" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011216", "lbl" : "organ system subdivision", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "A subdivision of an anatomical system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:67509" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "val" : "SCTID:91690000" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011222", "lbl" : "intra-ocular muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "AAO:0010038" + }, { + "val" : "EMAPA:18808" + }, { + "val" : "FMA:49150" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011233", "lbl" : "synovial membrane of synovial tendon sheath", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa.", + "xrefs" : [ "FMA:45087", "Wikipedia:Synovial_sheath" ] + }, + "comments" : [ "Alternate def: A synovial sheath is a layer of a tendon sheath containing tendons in the hand and foot. They lie internal to the fibrous tendon sheaths. An example is the common synovial sheath for the flexor tendons. [Wikipedia:Synovial_sheath]" ], + "xrefs" : [ { + "val" : "BTO:0001823" + }, { + "val" : "FMA:40878" + }, { + "val" : "Wikipedia:Synovial_sheath" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011234", "lbl" : "fibrous membrane of synovial tendon sheath", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:40877" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011241", + "lbl" : "ethmoid region", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The most anterior region of the braincase. Provides structural support for peripheral olfactory organ.", + "xrefs" : [ "UBERONREF:0000007", "http://palaeos.com/vertebrates/bones/braincase/ethmoid.html" ] + }, + "xrefs" : [ { + "val" : "AAO:0000986" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011249", "lbl" : "appendicular skeletal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7484" + }, { + "val" : "VSAO:0000306" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011270", "lbl" : "dorsal trunk", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the trunk that is in the dorsum[cjm].", + "xrefs" : [ "UBERONREF:0000006", "Wikipedia:Human_back" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35162" + }, { + "val" : "FMA:25056" + }, { + "val" : "MA:0000020" + }, { + "val" : "Wikipedia:Human_back" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011272", "lbl" : "embryonic skin basal layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001845" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011362", "lbl" : "cranial blood vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vasculature that is part of a head.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0005297" + }, { + "val" : "ZFA:0005297" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011565", "lbl" : "lumen of gastrointestinal system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:54364" + }, { + "val" : "SCTID:432899004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011566", "lbl" : "lumen of esophagus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that is part of a esophagus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18380" + }, { + "val" : "FMA:9398" + }, { + "val" : "SCTID:322648002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011582", "lbl" : "paired limb/fin skeleton", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The collection of all skeletal elements in an individual limb or fin.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000301" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011585", "lbl" : "cell condensation", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995).", + "xrefs" : [ "GO_REF:0000034", "PSPUB:0000170", "VSAO:0000006", "http://dx.plos.org/10.1371/journal.pone.0051070" ] + }, + "xrefs" : [ { + "val" : "VSAO:0000006" + }, { + "val" : "XAO:0004021" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011592", + "lbl" : "future upper lip", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0002120" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011595", "lbl" : "jaw region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32905" + }, { + "val" : "NCIT:C114916" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011596", "lbl" : "future lower lip", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001020" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011597", + "lbl" : "bone of upper jaw", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species).", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011642", "lbl" : "oral epithelium from ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that develops_from a ectoderm and is part of a oral epithelium.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004137" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011648", "lbl" : "jaw muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "AAO:0000247" + }, { + "val" : "EFO:0003511" + }, { + "val" : "TAO:0000236" + }, { + "val" : "XAO:0003269" + }, { + "val" : "ZFA:0000236" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011676", "lbl" : "subdivision of organism along main body axis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "lbl" : "trunk vertebra", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly.", + "xrefs" : [ "UBERONREF:0000006" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011695", "lbl" : "embryonic cardiovascular system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A cardiovascular system that is part of a conceptus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000216" + }, { + "val" : "FMA:305965" + }, { + "val" : "NCIT:C34148" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011772", "lbl" : "lower jaw opening", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is part of a bone of lower jaw.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000273" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011773", + "lbl" : "upper jaw opening", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is part of a bone of upper jaw.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "AAO:0000621" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011777", "lbl" : "nucleus of spinal cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neural nucleus that is part of the spinal cord.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:77011" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011779", "lbl" : "nerve of head region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A nerve that is part of a head.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011814", "lbl" : "non-neurogenic ectodermal placode", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ectodermal placode that does not develop into a component of the nervous system.", + "xrefs" : [ "PMID:11523831", "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011820", "lbl" : "atrioventricular region", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004149" + }, { + "val" : "FMA:85125" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011821", "lbl" : "irregular connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium.", + "xrefs" : [ "FMA:20107" ] + }, + "xrefs" : [ { + "val" : "FMA:20107" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011822", "lbl" : "dense irregular connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium.", + "xrefs" : [ "FMA:20109", "Wikipedia:Dense_irregular_connective_tissue" ] + }, + "xrefs" : [ { + "val" : "FMA:20109" + }, { + "val" : "NCIT:C32882" + }, { + "val" : "Wikipedia:Dense_irregular_connective_tissue" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011823", "lbl" : "dense connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets.", + "xrefs" : [ "Wikipedia:Dense_connective_tissue" ] + }, + "xrefs" : [ { + "val" : "AAO:0000121" + }, { + "val" : "NCIT:C32450" + }, { + "val" : "Wikipedia:Dense_connective_tissue" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011824", "lbl" : "fibrous connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:75634" + }, { + "val" : "SCTID:363130003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011825", "lbl" : "loose connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue.", + "xrefs" : [ "FMA:19783" ] + }, + "xrefs" : [ { + "val" : "FMA:19783" + }, { + "val" : "NCIT:C33007" + }, { + "val" : "Wikipedia:Loose_connective_tissue" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011858", "lbl" : "acinus of exocrine gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An acinus that is part of a exocrine gland.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011860", "lbl" : "collection of collagen fibrils", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:63212" + }, { + "val" : "MESH:D024022" + }, { + "val" : "NCIT:C32339" + }, { + "val" : "NIF_Subcellular:sao7547390221" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011861", "lbl" : "aorta collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity.", + "xrefs" : [ "MP:0011640" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011862", "lbl" : "pulmonary collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity.", + "xrefs" : [ "MP:0011641" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011863", "lbl" : "bone collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity.", + "xrefs" : [ "MP:0011642" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011864", "lbl" : "tendon collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity.", + "xrefs" : [ "MP:0011643" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011865", "lbl" : "corneal stroma collagen fibril", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity.", + "xrefs" : [ "MP:0011650" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011878", + "lbl" : "muscle layer of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of a wall of esophagus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:62998" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011892", "lbl" : "anterior uvea", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris.", + "xrefs" : [ "MP:0005194" ] + }, + "xrefs" : [ { + "val" : "SCTID:280656002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011899", "lbl" : "epimysium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous.", + "xrefs" : [ "Wikipedia:Epimysium" ] + }, + "xrefs" : [ { + "val" : "FMA:9726" + }, { + "val" : "NCIT:C32527" + }, { + "val" : "Wikipedia:Epimysium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011919", "lbl" : "yolk sac blood island", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Masses of developing blood cells attached to endothelium in the yolk sac.", + "xrefs" : [ "MP:0011204" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000177" + }, { + "val" : "EMAPA:16115" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011953", "lbl" : "stomach glandular region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of the stomach that is lined with glandular epithelium.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:17623" + }, { + "val" : "MA:0001613" + }, { + "val" : "NCIT:C77661" + }, { + "val" : "SCTID:27633001" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011955", + "lbl" : "left hepatic vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic vein that is part of a left lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14339" + }, { + "val" : "MA:0003032" + }, { + "val" : "SCTID:55188000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0011956", + "lbl" : "right hepatic vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic vein that is part of a right lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14338" + }, { + "val" : "MA:0003034" + }, { + "val" : "SCTID:18135006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0011997", "lbl" : "coelom", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The aggregate of the coelemic cavity lumen plus the membranes that line the lumen.", + "xrefs" : [ "UBERON:cjm", "Wikipedia:Body_cavity", "Wikipedia:Coelom" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004731" + }, { + "val" : "Wikipedia:Coelom" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012054", "lbl" : "myocoele", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The cavity within a myotome.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/myocoele" ] + }, + "xrefs" : [ { + "val" : "EMAPA:31134" + }, { + "val" : "VHOG:0001283" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012071", + "lbl" : "palate bone", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any bone that is part of a palate.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "NCIT:C33248" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012072", + "lbl" : "palatal part of dermatocranium", "type" : "CLASS" }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012075", "lbl" : "replacement bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Bone that forms as a replacement of another structural tissue.", + "xrefs" : [ "ZFA:0001628" ] + }, + "xrefs" : [ { + "val" : "AAO:0010768" + }, { + "val" : "TAO:0001637" + }, { + "val" : "ZFA:0001628" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012082", "lbl" : "bronchial lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical cavity that is part of a bronchus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:62646" + }, { + "val" : "SCTID:199401001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012172", "lbl" : "stomach primordium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A primordium that has the potential to develop into a stomach.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EFO:0002580" + }, { + "val" : "NCIT:C34305" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012180", "lbl" : "head or neck skin", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a craniocervical region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000574" + }, { + "val" : "NCIT:C12294" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012193", "lbl" : "phrenic vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins.", + "xrefs" : [ "ncithesaurus:Phrenic_Vein" ] + }, + "xrefs" : [ { + "val" : "MA:0002194" + }, { + "val" : "NCIT:C53062" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012254", "lbl" : "abdominal aorta artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that originates from the abdominal aorta.", + "xrefs" : [ "Wikipedia:Abdominal_aorta#Branches", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "SCTID:281470000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012274", "lbl" : "columnar epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified].", + "xrefs" : [ "Wikipedia:Columnar_epithelium" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Columnar_epithelium" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012275", "lbl" : "meso-epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium that derives from the mesoderm. [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:86452" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012314", "lbl" : "embryonic facial prominence", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of five swellings formed during the development of the face.", + "xrefs" : [ "http://www.indiana.edu/~anat550/hnanim/face/face.html" ] + }, + "xrefs" : [ { + "val" : "FMA:293103" + }, { + "val" : "SCTID:89066004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0012320", "lbl" : "cervical artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery of the neck.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "NCIT:C52850" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012321", + "lbl" : "deep cervical artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The deep cervical artery (Profunda cervicalis) is an artery of the neck.", + "xrefs" : [ "Wikipedia:Deep_cervical_artery" ] + }, + "xrefs" : [ { + "val" : "FMA:10659" + }, { + "val" : "SCTID:244223002" + }, { + "val" : "Wikipedia:Deep_cervical_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012324", + "lbl" : "transverse cervical artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery.", + "xrefs" : [ "Wikipedia:Transverse_cervical_artery" ] + }, + "xrefs" : [ { + "val" : "FMA:10664" + }, { + "val" : "MA:0001936" + }, { + "val" : "SCTID:244224008" + }, { + "val" : "Wikipedia:Transverse_cervical_artery" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012360", + "lbl" : "bone of jaw", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bone element that is part of a jaw region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35453" + }, { + "val" : "MA:0003130" + }, { + "val" : "SCTID:369003004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012361", + "lbl" : "internal anal region", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004588" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012367", + "lbl" : "muscle layer of intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of an intestine.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15697" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012375", + "lbl" : "subserosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of tissue between the muscularis and serosa.", + "xrefs" : [ "Wikipedia:Subserosa" ] + }, + "comments" : [ "Contains nerves, blood vessels, lymphatics and lymph nodes" ], + "xrefs" : [ { + "val" : "FMA:45636" + }, { + "val" : "NCIT:C94494" + }, { + "val" : "SCTID:2255006" + }, { + "val" : "Wikipedia:Subserosa" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012416", + "lbl" : "respiratory system arterial smooth muscle", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "MA:0001802" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012418", + "lbl" : "respiratory system venous smooth muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle tissue that is part of a respiratory system venous blood vessel.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001812" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012423", + "lbl" : "layer of microvilli", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified].", + "xrefs" : [ "GO:0005902", "Wikipedia:Microvillus" ] + }, + "xrefs" : [ { + "val" : "FMA:67296" + }, { + "val" : "MESH:D008871" + }, { + "val" : "NCIT:C33112" + }, { + "val" : "Wikipedia:Microvillus" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012425", + "lbl" : "striated border microvillus layer", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A microvillus layer that is striated and found in the intestine.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/striated+border", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:70978" + }, { + "val" : "NCIT:C33634" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012429", + "lbl" : "hematopoietic tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Blood-forming tissue, consisting of reticular fibers and cells.", + "xrefs" : [ "http://encyclopedia2.thefreedictionary.com/hematopoietic+tissue" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2142" + }, { + "val" : "FMA:14073" + }, { + "val" : "NCIT:C13051" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012430", + "lbl" : "tunica fibrosa of eyeball", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth.", + "xrefs" : [ "Wikipedia:Fibrous_tunic_of_eyeball" ] + }, + "xrefs" : [ { + "val" : "FMA:58102" + }, { + "val" : "SCTID:361318005" + }, { + "val" : "Wikipedia:Fibrous_tunic_of_eyeball" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "lbl" : "cloacal lumen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is enclosed by a cloaca.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "TAO:0000330" + }, { + "val" : "ZFA:0000330" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012464", + "lbl" : "cloacal vent", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012465", + "lbl" : "lumen of terminal part of digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is enclosed by a terminal part of digestive tract.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012466", + "lbl" : "extraembryonic cavity", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0000472" + }, { + "val" : "EMAPA:16054" + }, { + "val" : "VHOG:0000767" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012467", + "lbl" : "enclosed anatomical space", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space with no opening to another space or to the exterior.", + "xrefs" : [ "AEO:0000222" ] + }, + "xrefs" : [ { + "val" : "AEO:0000222" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012469", + "lbl" : "external anal region", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004589" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012475", + "lbl" : "skeleton of pectoral complex", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:24139" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012477", + "lbl" : "dorsal part of neck", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The posterior region of the neck, including the suboccipital region.", + "xrefs" : [ "MP:0012723" ] + }, + "xrefs" : [ { + "val" : "BTO:0000957" + }, { + "val" : "FMA:24189" + }, { + "val" : "SCTID:182326009" + }, { + "val" : "SCTID:304036007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012478", + "lbl" : "cloacal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a cloaca.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012480", + "lbl" : "cloacal mucosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a cloaca [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012481", + "lbl" : "cloacal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a cloaca.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27577" + }, { + "val" : "EMAPA:36070" + }, { + "val" : "ZFA:0005783" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012482", + "lbl" : "submucosa of cloaca", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosa that is part of a cloaca [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012483", + "lbl" : "serosa of cloaca", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous membrane that is part of a cloaca [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012485", + "lbl" : "cloacal villus", "type" : "CLASS" }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012321", - "lbl" : "deep cervical artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0012486", + "lbl" : "muscle layer of cloaca", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscular coat that is part of a cloaca.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012488", + "lbl" : "muscle layer of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscular coat that is part of a duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14944" + }, { + "val" : "SCTID:362147007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012489", + "lbl" : "muscle layer of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscular coat that is part of a colon.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27383" + }, { + "val" : "FMA:14986" + }, { + "val" : "MA:0003198" + }, { + "val" : "SCTID:362158003" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012490", + "lbl" : "muscle layer of anal canal", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscular coat that is part of a anal canal.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:15708" + }, { + "val" : "SCTID:362171000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012504", + "lbl" : "adventitia of esophagus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An adventitia that is part of a esophagus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63006" + }, { + "val" : "SCTID:85950006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "lbl" : "gastroduodenal junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junction that connects a stomach and connects a duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:17046" + }, { + "val" : "SCTID:264014000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0012651", + "lbl" : "mucosa of gastroduodenal junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a gastroduodenal junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0005415" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013126", + "lbl" : "vein of abdomen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that is part of a abdomen.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:281473003" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013127", + "lbl" : "pulmonary venous system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the venous system that drains the lungs[Kardong].", + "xrefs" : [ "ISBN:0073040584", "Wikipedia:Pulmonary_venous_system" ] + }, + "xrefs" : [ { + "val" : "Wikipedia:Pulmonary_venous_system" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013136", + "lbl" : "vein of lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vein that drains a lip.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:367664002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013140", + "lbl" : "systemic vein", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vein within the general circulation that transports blood back to the right atrium of the heart.", + "xrefs" : [ "ncithesaurus:Systemic_Vein" ] + }, + "xrefs" : [ { + "val" : "FMA:66644" + }, { + "val" : "NCIT:C33719" + }, { + "val" : "SCTID:244389004" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013158", + "lbl" : "foregut-midgut junction gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is part of a foregut-midgut junction.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000574" + }, { + "val" : "EMAPA:17065" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013212", + "lbl" : "anal sac gland secretion", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bodily secretion that is produced by a gland of anal sac.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013232", + "lbl" : "serous acinus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ] + }, + "xrefs" : [ { + "val" : "FMA:86279" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013411", + "lbl" : "cranial cavity", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical cavity that is the lumen of the skull and contains the brain.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:9644" + }, { + "val" : "MA:0003061" + }, { + "val" : "NCIT:C77638" + }, { + "val" : "SCTID:264452006" + }, { + "val" : "Wikipedia:Cranial_cavity" + }, { + "val" : "neuronames:2806" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013479", + "lbl" : "lung endothelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel endothelium that is part of a lung [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BTO:0004128" + }, { + "val" : "CALOHA:TS-0573" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013501", + "lbl" : "cloacal sphincter", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphincter muscle that is part of a cloaca.", + "xrefs" : [ "OBOL:automatic" ] + }, + "comments" : [ "the muscles of the cloacal sphincter specialise into the perineal muscles in mammals (Gegenbaur, 1883; Popowsky, 1899; Nishi, 1938)." ], + "xrefs" : [ { + "val" : "NCIT:C34129" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "lbl" : "caudal vertebra cartilage element", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A caudal vertebra endochondral element that is composed primarily of cartilage tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000260" + }, { + "val" : "EMAPA:18044" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012324", - "lbl" : "transverse cervical artery", + "id" : "http://purl.obolibrary.org/obo/UBERON_0013504", + "lbl" : "caudal vertebra pre-cartilage condensation", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18045" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012360", - "lbl" : "bone of jaw", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012375", - "lbl" : "subserosa", + "id" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "lbl" : "cervical vertebra cartilage element", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A cervical vertebra endochondral element that is composed primarily of cartilage tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000240" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012416", - "lbl" : "respiratory system arterial smooth muscle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0013506", + "lbl" : "cervical vertebra pre-cartilage condensation", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation.", + "xrefs" : [ "OBOL:automatic" ] + } } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012418", - "lbl" : "respiratory system venous smooth muscle", + "id" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "lbl" : "thoracic vertebra cartilage element", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A thoracic vertebra endochondral element that is composed primarily of cartilage tissue.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002014" } ] } }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012429", - "lbl" : "hematopoietic tissue", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012430", - "lbl" : "tunica fibrosa of eyeball", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012466", - "lbl" : "extraembryonic cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012467", - "lbl" : "enclosed anatomical space", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012475", - "lbl" : "skeleton of pectoral complex", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0012504", - "lbl" : "adventitia of esophagus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013126", - "lbl" : "vein of abdomen", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013127", - "lbl" : "pulmonary venous system", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013136", - "lbl" : "vein of lip", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013140", - "lbl" : "systemic vein", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013232", - "lbl" : "serous acinus", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013411", - "lbl" : "cranial cavity", - "type" : "CLASS" - }, { - "id" : "http://purl.obolibrary.org/obo/UBERON_0013479", - "lbl" : "lung endothelium", - "type" : "CLASS" + "id" : "http://purl.obolibrary.org/obo/UBERON_0013508", + "lbl" : "thoracic vertebra pre-cartilage condensation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013514", "lbl" : "space surrounding organism", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The space that surrounds an organism.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013522", "lbl" : "subdivision of tube", @@ -22750,111 +81700,379 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013525", "lbl" : "stomach lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The anatomical space that is enclosed by a stomach.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18395" + }, { + "val" : "FMA:14585" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013636", + "lbl" : "epithelium of intestinal villus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a intestinal villus.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63587" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013685", "lbl" : "foramen of skull", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical space that is an opening in a bone of the skull.", + "xrefs" : [ "TAO:curator", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:53165" + }, { + "val" : "SCTID:276742007" + }, { + "val" : "Wikipedia:Foramina_of_the_skull" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013686", "lbl" : "anatomical conduit space", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified].", + "xrefs" : [ "FMA:9338", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:9338" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013694", "lbl" : "brain endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vascular endothelium found in blood vessels of the blood-brain-barrier.", + "xrefs" : [ "CALOHA:TS-0092" ] + }, + "xrefs" : [ { + "val" : "BTO:0001852" + }, { + "val" : "BTO:0003248" + }, { + "val" : "CALOHA:TS-0092" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013695", + "lbl" : "colon endothelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Vascular endothelium found in colon blood vessels.", + "xrefs" : [ "CALOHA:TS-0162" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-0162" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0013697", + "lbl" : "exocrine pancreas epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium lining the exocrine pancreas.", + "xrefs" : [ "CALOHA:TS-2108" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2108" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013700", "lbl" : "axial musculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Musculature of the head and neck, spine, and ribs.", + "xrefs" : [ "HP:0003327" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0000159" + }, { + "val" : "EMAPA:18166" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013701", "lbl" : "main body axis", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages.", + "xrefs" : [ "https://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013702", "lbl" : "body proper", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The region of the organism associated with the visceral organs.", + "xrefs" : [ "AEO:0000103" ] + }, + "xrefs" : [ { + "val" : "AEO:0000103" + }, { + "val" : "BTO:0001489" + }, { + "val" : "FMA:231424" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013704", "lbl" : "notochordal canal", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/notochordal+canal" ] + }, + "xrefs" : [ { + "val" : "FMA:293127" + }, { + "val" : "NCIT:C34230" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013727", "lbl" : "notochordal fluid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fluid contained within the notochordal canal.", + "xrefs" : [ "http://animaldiversity.org/accounts/Latimeria_chalumnae/", "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Distinct feature of coelocanths" ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013754", "lbl" : "integumentary system layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An organ component layer that is part of a integumental system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "SCTID:314820002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013755", "lbl" : "arterial blood", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood that is part of a artery.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:83066" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013756", "lbl" : "venous blood", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood that is part of a vein.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:83067" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013757", "lbl" : "capillary blood", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood that is part of a capillary.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:263901" + }, { + "val" : "NCIT:C32212" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013765", "lbl" : "digestive system element", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "SCTID:272627002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0013768", "lbl" : "great vessel of heart", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart.", + "xrefs" : [ "Wikipedia:Great_vessels" ] + }, + "comments" : [ "Groupings may vary - typically pulmonary vessels and aorta and vena cavae" ], + "xrefs" : [ { + "val" : "EMAPA:36460" + }, { + "val" : "SCTID:304066000" + }, { + "val" : "Wikipedia:Great_vessels" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014387", "lbl" : "mesenchyme derived from neural crest", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that develops_from the neural crest[Automatically generated definition].", + "xrefs" : [ "OBOL:automatic", "https://github.com/obophenotype/uberon/issues/248" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32735" + }, { + "val" : "FMA:293883" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014398", "lbl" : "respiratory muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle that is part of the respiratory system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014399", "lbl" : "sinusoidal space", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is enclosed by a sinusoid.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63133" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0014400", + "lbl" : "hepatic sinusoidal space", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sinusoidal space that is part of a hepatic sinusoid.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:262090" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014402", "lbl" : "sex-specific anatomical structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A part of the body present only in a specific gender.", + "xrefs" : [ "AEO:0000174", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000174" + }, { + "val" : "WBbt:0005752" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014404", "lbl" : "female anatomical structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A part of the body present only in females.", + "xrefs" : [ "AEO:0000176", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000176" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014454", "lbl" : "visceral abdominal adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subcutaneous adipose tissue that is located in the peritoneal cavity.", + "xrefs" : [ "CALOHA:paula", "MGI:csmith", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/259" ] + }, + "xrefs" : [ { + "val" : "BTO:0004041" + }, { + "val" : "CALOHA:TS-2405" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014455", "lbl" : "subcutaneous abdominal adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subcutaneous adipose tissue that is located in the abdominal region.", + "xrefs" : [ "CALOHA:paula", "MGI:csmith", "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/259" ] + }, + "xrefs" : [ { + "val" : "CALOHA:TS-2406" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014477", "lbl" : "thoracic skeleton", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum.", + "xrefs" : [ "Wikipedia:Rib_cage", "https://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002013" + }, { + "val" : "FMA:77169" + }, { + "val" : "Wikipedia:Thoracic_skeleton" } ] } }, { @@ -22862,9 +82080,14 @@ "lbl" : "thoracic spinal cord ventral horn", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A ventral horn of spinal cord that is part of a thoracic spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1410" + }, { + "val" : "SCTID:367876000" } ] } }, { @@ -22872,9 +82095,14 @@ "lbl" : "cervical spinal cord gray matter", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gray matter of spinal cord that is part of a cervical spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1521" + }, { + "val" : "SCTID:362438009" } ] } }, { @@ -22882,9 +82110,14 @@ "lbl" : "cervical spinal cord ventral horn", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A ventral horn of spinal cord that is part of a cervical spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:1680" + }, { + "val" : "SCTID:174363005" } ] } }, { @@ -22892,23 +82125,89 @@ "lbl" : "thoracic spinal cord gray matter", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A gray matter of spinal cord that is part of a thoracic spinal cord.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "BIRNLEX:980" + }, { + "val" : "SCTID:362441000" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "lbl" : "frontonasal process epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a frontonasal prominence.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004108" + }, { + "val" : "EMAPA:32918" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0014703", + "lbl" : "anal membrane ectodermal component", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A unilaminar epithelium that develops_from a ectoderm and is part of a anal region.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004019" + }, { + "val" : "EMAPA:25040" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014704", "lbl" : "pleuroperitoneal canal lumen", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is enclosed by a pleuroperitoneal canal.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004736" + }, { + "val" : "EMAPA:25034" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014716", "lbl" : "interlobular duct", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory.", + "xrefs" : [ "ncithesaurus:Interlobular_Duct" ] + }, + "xrefs" : [ { + "val" : "NCIT:C32828" + }, { + "val" : "UMLS:C1512857" + }, { + "val" : "Wikipedia:Interlobular_ducts" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0014717", + "lbl" : "mucous acinus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "http://www.siumed.edu/~dking2/intro/glands.htm" ] + }, + "xrefs" : [ { + "val" : "FMA:86278" } ] } }, { @@ -22916,263 +82215,1176 @@ "lbl" : "intralobular duct", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular.", + "xrefs" : [ "http://www.siumed.edu/~dking2/intro/glands.htm" ] + }, + "xrefs" : [ { + "val" : "SCTID:205214009" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014720", "lbl" : "interlobar duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory.", + "xrefs" : [ "http://www.siumed.edu/~dking2/intro/glands.htm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014776", "lbl" : "midbrain neuromere", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuromere that is part of the presumptive midbrain.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0004352" + }, { + "val" : "FMA:61997" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014777", "lbl" : "spinal neuromere", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuromere that is part of the presumptive spinal cord.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001332" + }, { + "val" : "ZFA:0001332" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0014783", + "lbl" : "cloacal muscle", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a cloaca.", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014793", "lbl" : "musculature of pectoral complex", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:71296" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014794", "lbl" : "pectoral appendage muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin).", + "xrefs" : [ "OBOL:automatic" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014892", "lbl" : "skeletal muscle organ, vertebrate", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles).", + "xrefs" : [ "GOC:dos" ] + }, + "xrefs" : [ { + "val" : "AAO:0011099" + }, { + "val" : "BTO:0001103" + }, { + "val" : "CALOHA:TS-0933" + }, { + "val" : "EFO:0000888" + }, { + "val" : "EHDAA:5035" + }, { + "val" : "EHDAA:5043" + }, { + "val" : "EHDAA:5978" + }, { + "val" : "EHDAA:5984" + }, { + "val" : "EMAPA:35988" + }, { + "val" : "EV:0100377" + }, { + "val" : "GAID:141" + }, { + "val" : "MA:0003148" + }, { + "val" : "MAT:0000302" + }, { + "val" : "MESH:D018482" + }, { + "val" : "MIAA:0000302" + }, { + "val" : "TAO:0005277" + }, { + "val" : "VHOG:0000319" + }, { + "val" : "XAO:0000174" + }, { + "val" : "ZFA:0005277" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014903", "lbl" : "primordial vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of tissue that will develop into vasculature.", + "xrefs" : [ "ZFA:0005076", "ZFA:curator" ] + }, + "xrefs" : [ { + "val" : "EFO:0003708" + }, { + "val" : "TAO:0005076" + }, { + "val" : "ZFA:0005076" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0014907", "lbl" : "intersomitic vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites.", + "xrefs" : [ "MGI:anna" ] + }, + "xrefs" : [ { + "val" : "EFO:0003664" + }, { + "val" : "TAO:0001285" + }, { + "val" : "XAO:0004075" + }, { + "val" : "ZFA:0001285" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015007", + "lbl" : "cervical vertebra endochondral element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vertebral endochondral element in the cervical region of the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "lbl" : "thoracic vertebra endochondral element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A vertebral endochondral element in the thoracic region of the vertebral column.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015060", + "lbl" : "sphenoid endochondral element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A sphenoid bone or its cartilage or pre-cartilage precursor.", + "xrefs" : [ "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015128", "lbl" : "subepicardial layer of epicardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:83105" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015129", "lbl" : "epicardial fat", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Visceral intrapericardial fat contiguous with the myocardial surface.", + "xrefs" : [ "DOI:10.5935/abc.20130138" ] + }, + "xrefs" : [ { + "val" : "FMA:9871" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015152", "lbl" : "gland of ocular region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "https://github.com/obophenotype/uberon/issues/614" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015165", "lbl" : "multi-unit eye", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An eye consisting of multiple light-sensing organs.", + "xrefs" : [ "PMID:21062451", "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015178", "lbl" : "somite border", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region of somite adjacent to presomitic mesoderm.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001462" + }, { + "val" : "XAO:0004074" + }, { + "val" : "ZFA:0001462" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015179", "lbl" : "somite boundary epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium located in the intersomitic region.", + "xrefs" : [ "XAO:0004077", "XAO:EJS" ] + }, + "xrefs" : [ { + "val" : "XAO:0004077" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015203", "lbl" : "non-connected functional system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical group whose component structures share a common function.", + "xrefs" : [ "AEO:0000093", "AEO:JB", "FBC:DOS", "FBbt:00007278" ] + }, + "xrefs" : [ { + "val" : "AEO:0000093" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015204", "lbl" : "glandular system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A non-connected functional system that is composed primarily of a gland.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EHDAA2:0002223" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015212", "lbl" : "lateral structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any structure that is placed on one side of the left-right axis of a bilaterian.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015228", "lbl" : "circulatory organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015280", + "lbl" : "pancreas left lobe", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pancreatic lobule that is in_the_left_side_of a exocrine pancreas.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000722" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015281", + "lbl" : "pancreas right lobe", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A pancreatic lobule that is in_the_right_side_of a exocrine pancreas.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0000723" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015329", "lbl" : "respiratory system basement membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A basement membrane of epithelium that is part of a respiratory system.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "MA:0001815" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015410", "lbl" : "heart plus pericardium", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "MA:0002449" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015480", + "lbl" : "proper hepatic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery.", + "xrefs" : [ "Wikipedia:Hepatic_artery_proper" ] + }, + "xrefs" : [ { + "val" : "FMA:14772" + }, { + "val" : "MA:0003095" + }, { + "val" : "SCTID:244262006" + }, { + "val" : "Wikipedia:Hepatic_artery_proper" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "lbl" : "left hepatic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic artery that is part of a left lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14779" + }, { + "val" : "MA:0003096" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "lbl" : "right hepatic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hepatic artery that is part of a right lobe of liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14778" + }, { + "val" : "MA:0003097" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015485", + "lbl" : "choledocho-duodenal junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla.", + "xrefs" : [ "http://medical-dictionary.thefreedictionary.com/choledochoduodenal+junction" ] + }, + "xrefs" : [ { + "val" : "MA:0003108" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015716", + "lbl" : "anal canal epithelium", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a anal canal.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:18835" + }, { + "val" : "FMA:17511" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015757", "lbl" : "heterogeneous tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:62798" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015783", "lbl" : "smooth muscle layer in fatty layer of subcutaneous tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A smooth muscle tissue that is part of a hypodermis.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:77862" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015796", + "lbl" : "liver blood vessel", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel that is part of a liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35498" + }, { + "val" : "MA:0003137" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015808", "lbl" : "eye epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a camera-type eye.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:35957" + }, { + "val" : "MA:0003162" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0015833", "lbl" : "foregut epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is part of a foregut.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32922" + }, { + "val" : "MA:0003204" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0015834", + "lbl" : "duodenum lamina propria", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A lamina propria that is part of a duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:27255" + }, { + "val" : "FMA:15972" + }, { + "val" : "MA:0003209" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016405", "lbl" : "pulmonary capillary", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "A capillary that is part of a lung.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:14121" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016458", "lbl" : "esophageal hiatus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A hole in the diaphragm through which the esophagus passes.", + "xrefs" : [ "HP:0002036" ] + }, + "xrefs" : [ { + "val" : "FMA:58289" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016478", + "lbl" : "liver stroma", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stroma that is part of a liver.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:17553" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016490", "lbl" : "auditory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Is the sensory system for the sense of hearing.", + "xrefs" : [ "NLXANAT:090817" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36002" + }, { + "val" : "FMA:7192" + }, { + "val" : "MA:0002443" + }, { + "val" : "NCIT:C12889" + }, { + "val" : "NLXANAT:090817" + }, { + "val" : "Wikipedia:Auditory_system" + }, { + "val" : "neuronames:2888" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016509", "lbl" : "cavity of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Luminal space of the right ventricle of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26047" + }, { + "val" : "FMA:9291" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016512", + "lbl" : "lumen of duodenum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical space that is part of a duodenum.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:19080" + }, { + "val" : "FMA:14589" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016513", "lbl" : "cavity of left atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Luminal space of the left atrium of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26011" + }, { + "val" : "FMA:9465" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016514", "lbl" : "cavity of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Luminal space of the left ventricle of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26038" + }, { + "val" : "FMA:9466" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016522", "lbl" : "cavity of right atrium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Luminal space of the right atrium of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "EMAPA:26020" + }, { + "val" : "FMA:11359" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016545", "lbl" : "pharyngeal ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches.", + "xrefs" : [ "PMID:23020903", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "TAO:0001379" + }, { + "val" : "ZFA:0001379" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016548", "lbl" : "central nervous system gray matter layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A layer of of the central nervous system that is part of gray matter.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:83142" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016550", "lbl" : "spinal cord column", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016552", + "lbl" : "phlegm", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mucus produced in the respiratory tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "NCIT:C93171" + }, { + "val" : "UMLS:C0225378" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016553", + "lbl" : "respiratory system mucus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm).", + "xrefs" : [ "Wikipedia:Nasal_mucus#Respiratory_system", "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016566", + "lbl" : "pit", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An roughly circular indentation in a surface.", + "xrefs" : [ "AEO:0000204", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000204" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016570", "lbl" : "lamina of gray matter of spinal cord", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:68861" + }, { + "val" : "Wikipedia:Rexed_laminae" + }, { + "val" : "http://neurolex.org/wiki/Category:Rexed_spinal_cord_parcellation_scheme_region" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "lbl" : "dorsal part of optic cup", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The dorsal region of the optic cup that gives rise to the dorsal part of the retina.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016879", "lbl" : "future central nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primordium that develops into the central nervous system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016880", "lbl" : "future nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Primordium that develops into the nervous system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "AAO:0000477" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016885", + "lbl" : "epithelium of terminal part of digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Epithelium lining the distalmost portion of the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0005445" + }, { + "val" : "WBbt:0005800" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0016886", + "lbl" : "muscle tissue of terminal part of digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any muscle tissue of the distalmost portion of the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016887", "lbl" : "entire extraembryonic component", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism.", + "xrefs" : [ "AEO:0000195", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000195" + }, { + "val" : "EHDAA2:0000003" + }, { + "val" : "EMAPA:16042" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0016888", "lbl" : "transitional anatomical structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development.", + "xrefs" : [ "AEO:0000132", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0000132" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0017650", "lbl" : "developing mesenchymal structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure.", + "xrefs" : [ "AEO:0001016", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0001016" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0017672", "lbl" : "abdominal viscera", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A viscus that is part of a abdomen.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:32413" + }, { + "val" : "FMA:67355" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018111", + "lbl" : "muscle layer of rectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of the rectum.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:15035" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "lbl" : "rectum smooth muscle tissue", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of smooth muscle tissue that is part of the rectum.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018135", "lbl" : "fibrocollagenous connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:83521" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018142", + "lbl" : "caudal vertebra endochondral element", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx).", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018150", "lbl" : "skin of lower lip", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a lower lip.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:24767" + }, { + "val" : "SCTID:281630002" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018151", + "lbl" : "skin of upper lip", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of a upper lip.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:24765" + }, { + "val" : "SCTID:281629007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018234", + "lbl" : "stroma of pancreas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A stroma that is part of a pancreas.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:63121" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018239", "lbl" : "rhombomere boundary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A boundary delimiting a rhombomere.", + "xrefs" : [ "GO:0021654" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018254", "lbl" : "skeletal musculature", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "EHDAA2:0001842" + }, { + "val" : "EMAPA:35578" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018257", "lbl" : "submucosa of digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of submucosa that lines the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018260", "lbl" : "layer of muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any organ component layer that consists of muscle tissue.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:45634" + }, { + "val" : "NCIT:C75444" + }, { + "val" : "UMLS:C0225358" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018261", + "lbl" : "muscular coat of digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscular coat that is part of a digestive tract.", + "xrefs" : [ "OBOL:automatic" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018415", + "lbl" : "ethmoid foramen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An bone foramen in the ethmoid bone.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "Taxon nodes: In humans, refers to anterior or posterior ethmoid foramina" ], + "xrefs" : [ { + "val" : "Wikipedia:Ethmoidal_foramina" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018543", + "lbl" : "lumen of intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The anatomical space within the intestine.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:14586" + }, { + "val" : "TADS:0000495" + }, { + "val" : "WBbt:0005791" + }, { + "val" : "ZFA:0005807" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018544", "lbl" : "trigeminal nerve muscle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Muscle innervated by the trigeminal nerve (Cranial Nerve V).", + "xrefs" : [ "MFMO:0000072" ] + }, + "xrefs" : [ { + "val" : "MFMO:0000072" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018649", "lbl" : "cardiac muscle tissue of ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:83450" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0018674", "lbl" : "heart vasculature", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart.", + "xrefs" : [ "ZFA:0005811", "ZFA:CVS" ] + }, + "xrefs" : [ { + "val" : "FMA:73747" + }, { + "val" : "ZFA:0005811" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "lbl" : "dorsal side of post-anal tail", "type" : "CLASS" + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0018707", + "lbl" : "bladder organ", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A membranous sac in animals that serves as the receptacle of a liquid or contains gas.", + "xrefs" : [ "BTO:0000123" ] + }, + "xrefs" : [ { + "val" : "BTO:0000123" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019042", "lbl" : "reproductive system mucosa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0002439" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019143", "lbl" : "intramuscular adipose tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes.", + "xrefs" : [ "BTO:0004043" ] + }, + "xrefs" : [ { + "val" : "BTO:0004043" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019189", "lbl" : "carotid artery endothelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0004626" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "lbl" : "mucous gland of lung", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0004638" + }, { + "val" : "FMA:13119" + }, { + "val" : "SCTID:88410004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019204", "lbl" : "skin epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any region of epithelium that is part of a skin region.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0004382" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019207", "lbl" : "chorioretinal region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the eye that consists of both the retina and the optic choroid.", + "xrefs" : [ "UBERON:drseb", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "SCTID:110701000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019263", "lbl" : "gray matter of hindbrain", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "DHBA:10654" + }, { + "val" : "FMA:268630" } ] } }, { @@ -23180,81 +83392,211 @@ "lbl" : "gray matter of midbrain", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "DHBA:10649" + }, { + "val" : "FMA:83913" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019304", "lbl" : "sensory organ epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:35952" + }, { + "val" : "MA:0003174" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0019319", "lbl" : "exocrine gland of integumental system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An exocrine gland that is part of a integumental system.", + "xrefs" : [ "GOC:dos", "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022288", "lbl" : "surface of eyeball", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:58315" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0022292", + "lbl" : "splenic arteriole", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "NCIT:C33596" + }, { + "val" : "SCTID:282511007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022293", "lbl" : "reproductive gland secretion", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of organism substance that is secreted by a reproductive gland.", + "xrefs" : [ "UBERON:cjm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022303", "lbl" : "nervous system cell part layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO].", + "xrefs" : [ "NLX:149357" ] + }, + "xrefs" : [ { + "val" : "NLX:149357" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022350", "lbl" : "visceral serous membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Serous membrane layer that is adjacent to and lines an organ.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:15860" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022351", "lbl" : "parietal serous membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Serous membrane layer that lines to a body cavity.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:15859" + }, { + "val" : "MA:0002448" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0022361", "lbl" : "lung field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A specific region of the foregut into the area in which the lung will develop.", + "xrefs" : [ "GOC:dph", "GOC:mtg_lung" ] + }, + "xrefs" : [ { + "val" : "SCTID:34922002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034705", "lbl" : "developing neuroepithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An embryonic or larval epithelium that is committed to form part of the nervous system.", + "xrefs" : [ "AEO:0001008", "AEO:JB" ] + }, + "xrefs" : [ { + "val" : "AEO:0001008" + }, { + "val" : "BTO:0000314" + }, { + "val" : "EHDAA2_RETIRED:0004654" + }, { + "val" : "FMA:64807" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034706", "lbl" : "proliferating neuroepithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells.", + "xrefs" : [ "AEO:0001009" ] + }, + "xrefs" : [ { + "val" : "AEO:0001009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034707", "lbl" : "differentiating neuroepithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells.", + "xrefs" : [ "AEO:0001010" ] + }, + "xrefs" : [ { + "val" : "AEO:0001010" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034709", "lbl" : "hindbrain marginal layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "DHBA:12694" + }, { + "val" : "EMAPA:32916" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034710", "lbl" : "spinal cord ventricular layer", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0001267" + }, { + "val" : "EMAPA:17585" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034713", "lbl" : "cranial neuron projection bundle", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain.", + "xrefs" : [ "ISBN:0471888893", "http://orcid.org/0000-0002-6601-2165" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034728", "lbl" : "autonomic nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa.", + "xrefs" : [ "Wikipedia:Autonomic_nerve" ] + }, + "xrefs" : [ { + "val" : "FMA:5866" + }, { + "val" : "MESH:D017776" + }, { + "val" : "SCTID:276145003" + }, { + "val" : "Wikipedia:Autonomic_nerve" } ] } }, { @@ -23262,31 +83604,74 @@ "lbl" : "sympathetic nerve", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "xrefs" : [ { + "val" : "SCTID:181098007" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034769", "lbl" : "lymphomyeloid tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:79770" + }, { + "val" : "NCIT:C41168" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034873", "lbl" : "bodily gas", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any substance in the body or expelled from the body that is in a gaseous state.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:84580" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034874", "lbl" : "air in respiratory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of gas located in a part of the respiratory system that is composed primarily of air.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:84581" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034878", "lbl" : "prechordal mesoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The area of axial mesoderm that develops into the prechordal plate.", + "xrefs" : [ "MGI:anna" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034903", "lbl" : "left atrium endocardium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Endocardium that is part of the left atrium.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7286" + }, { + "val" : "SCTID:190064008" + }, { + "val" : "VHOG:0001226" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034905", "lbl" : "gland lumen", @@ -23296,15 +83681,12 @@ "lbl" : "multi organ part structure", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "An multicellular anatomical structure that has subparts of multiple organs as a part.", + "xrefs" : [ "CARO:0020001" ] + }, + "xrefs" : [ { + "val" : "CARO:0020001" } ] } }, { @@ -23312,15 +83694,14 @@ "lbl" : "cell cluster", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "definition" : { + "val" : "A cluster of cells, largely surrounded by a morphological boundary.", + "xrefs" : [ "CARO:0020002" ] + }, + "xrefs" : [ { + "val" : "CARO:0020002" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "FMA:62807" } ] } }, { @@ -23328,15 +83709,12 @@ "lbl" : "disconnected anatomical group", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "definition" : { + "val" : "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other.", + "xrefs" : [ "CARO:0020000" ] + }, + "xrefs" : [ { + "val" : "CARO:0020000" } ] } }, { @@ -23344,45 +83722,133 @@ "lbl" : "anatomical collection", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" - } ] + "definition" : { + "val" : "A collection of anatomical structures that are alike in terms of their morphology or developmental origin.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034929", "lbl" : "external soft tissue zone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0034932", + "lbl" : "epithelium of biliary system", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts.", + "xrefs" : [ "BTO:0001513", "MGI:cs", "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "BTO:0001513" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034933", "lbl" : "layer of smooth muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any organ component layer that consists of smooth muscle tissue.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034944", "lbl" : "zone of organ", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:55268" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0034945", + "lbl" : "excreted gas", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any gaseous product of an excretory process.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0034946", + "lbl" : "gas excreted from digestive tract", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any excreted gas that is produced by the digestive tract.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "comments" : [ "In mammals, mostly produced as a byproduct of bacterial fermentation in the gastrointestinal (GI) tract, especially the colon, and excreted through the rectum" ], + "xrefs" : [ { + "val" : "FMA:78440" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034947", "lbl" : "gas in respiratory system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any portion of gas located in a part of the respiratory system.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034969", "lbl" : "epithelial layer of duct", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "NCIT:C25787" + }, { + "val" : "UMLS:C1512086" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0034995", "lbl" : "jaw mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Mesenchyme that is part of a developing jaw [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "EMAPA:32907" + }, { + "val" : "EMAPA:35454" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035037", "lbl" : "jaw epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EMAPA:32904" + }, { + "val" : "MA:0003220" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0035039", + "lbl" : "rectal artery", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "SCTID:277967008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035050", "lbl" : "excretory duct", @@ -23390,205 +83856,568 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035118", "lbl" : "material entity in digestive tract", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included.", + "xrefs" : [ "https://github.com/EnvironmentOntology/envo/issues/110" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035159", "lbl" : "entire surface of organism", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface.", + "xrefs" : [ "FMA:61695" ] + }, + "xrefs" : [ { + "val" : "FMA:61695" + }, { + "val" : "NCIT:C29667" + }, { + "val" : "SCTID:261060002" + }, { + "val" : "UMLS:C0489451" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035398", "lbl" : "branch of external carotid artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:70505" + }, { + "val" : "NCIT:C32552" + }, { + "val" : "SCTID:244216003" + }, { + "val" : "UMLS:C0447038" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035539", "lbl" : "esophageal artery", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "Any of several arteries that arise from the aorta and supply blood to the esophagus.", + "xrefs" : [ "ncithesaurus:Esophageal_Artery" ] + }, + "xrefs" : [ { + "val" : "FMA:4149" + }, { + "val" : "NCIT:C32535" + }, { + "val" : "SCTID:56548006" + }, { + "val" : "UMLS:C0226294" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035546", "lbl" : "uveal vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:51797" + }, { + "val" : "SCTID:149683007" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0035548", + "lbl" : "colic artery", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "SCTID:77852007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035549", "lbl" : "vasculature of integument", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + "definition" : { + "val" : "The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:225275" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035550", "lbl" : "superficial vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers.", + "xrefs" : [ "ncithesaurus:Superficial_Vein" ] + }, + "xrefs" : [ { + "val" : "FMA:76719" + }, { + "val" : "NCIT:C33666" + }, { + "val" : "SCTID:341382008" + }, { + "val" : "UMLS:C0226513" + }, { + "val" : "Wikipedia:Superficial_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035551", "lbl" : "deep vasculature", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035552", "lbl" : "deep vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery.", + "xrefs" : [ "ncithesaurus:Deep_Vein" ] + }, + "xrefs" : [ { + "val" : "FMA:76718" + }, { + "val" : "NCIT:C32444" + }, { + "val" : "SCTID:341484008" + }, { + "val" : "UMLS:C0226514" + }, { + "val" : "Wikipedia:Deep_vein" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035553", "lbl" : "left cardiac chamber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any chamber of the left side of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7166" + }, { + "val" : "SCTID:362008007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035554", "lbl" : "right cardiac chamber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any chamber of the right side of the heart.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165" ] + }, + "xrefs" : [ { + "val" : "FMA:7165" + }, { + "val" : "SCTID:362007002" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035639", "lbl" : "ocular adnexa", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.", + "xrefs" : [ "HPO:pr", "UBERON:cjm", "http://medical-dictionary.thefreedictionary.com/ocular+adnexa", "https://github.com/obophenotype/uberon/issues/1132" ] + }, + "xrefs" : [ { + "val" : "FMA:76554" + }, { + "val" : "NCIT:C32574" + }, { + "val" : "SCTID:120612006" + }, { + "val" : "UMLS:C0229243" + }, { + "val" : "Wikipedia:Accessory_visual_structures" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035763", "lbl" : "cavity of cardiac chamber", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004181" + }, { + "val" : "FMA:9464" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035767", "lbl" : "intrapulmonary bronchus", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:223208" + }, { + "val" : "NCIT:C12930" + }, { + "val" : "UMLS:C1512970" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035804", "lbl" : "future mouth", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The primordial mouth region of the developing head.", + "xrefs" : [ "MP:0003119" ] + }, + "xrefs" : [ { + "val" : "FMA:293105" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0035805", + "lbl" : "muscle layer of sigmoid colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle layer that is part of the sigmoid colon.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/1162" ] + }, + "xrefs" : [ { + "val" : "FMA:15028" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035809", "lbl" : "serous cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:12241" + }, { + "val" : "SCTID:304404008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035814", "lbl" : "pericardial fat", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The sum of epicardial and paracardial fat deposits.", + "xrefs" : [ "DOI:10.5935/abc.20130138" ] + }, + "xrefs" : [ { + "val" : "SCTID:42267001" + }, { + "val" : "ZFA:0005765" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035815", "lbl" : "paracardial fat", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Fat deposits in the mediastinum outside the parietal pericardium .", + "xrefs" : [ "DOI:10.5935/abc.20130138" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035818", "lbl" : "visceral fat", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any fat deposit surrounding a visceral organ.", + "xrefs" : [ "UBERON:cjm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035819", "lbl" : "abdominopelvic cavity", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity.", + "xrefs" : [ "UBERON:cjm" ] + }, + "xrefs" : [ { + "val" : "FMA:12267" + }, { + "val" : "Wikipedia:Abdominopelvic_cavity" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035820", "lbl" : "peritoneal sac", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/86" ] + }, + "xrefs" : [ { + "val" : "EMAPA:16137" + }, { + "val" : "FMA:9908" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0035965", "lbl" : "wall of blood vessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "BTO:0004378" + }, { + "val" : "FMA:67473" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036072", "lbl" : "respiratory primordium epithelium", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004070" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036073", "lbl" : "respiratory primordium mesenchyme", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "EHDAA2:0004071" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036146", "lbl" : "cardiopharyngeal field", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles.", + "xrefs" : [ "http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1", "https://orcid.org/0000-0003-3308-6245" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036186", "lbl" : "fibroelastic connective tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:83520" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0036214", + "lbl" : "rectosigmoid junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junction that is between the sigmoid colon and rectum.", + "xrefs" : [ "NCIT:C54188", "https://github.com/obophenotype/uberon/issues/1319", "https://www.cdc.gov/cancer/npcr/pdf/abstracting/colon.pdf" ] + }, + "xrefs" : [ { + "val" : "NCIT:C54188" + }, { + "val" : "SCTID:245429006" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036215", "lbl" : "anatomical surface region", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + "definition" : { + "val" : "Material anatomical entity that forms the outermost boundary of an anatomical structure.", + "xrefs" : [ "https://github.com/obophenotype/uberon/issues/1324" ] + }, + "xrefs" : [ { + "val" : "AAO:0010270" }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + "val" : "ZFA:0005594" } ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036217", "lbl" : "coelomic fluid", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A bodily fluid that is located in the coelom.", + "xrefs" : [ "PMID:10874572", "https://github.com/obophenotype/uberon/issues/1326" ] + }, + "xrefs" : [ { + "val" : "BTO:0001708" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036225", "lbl" : "respiratory system gland", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any gland that is part os the respiratory system.", + "xrefs" : [ "UBERON:cjm" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036242", "lbl" : "post-embryonic notochord", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_118072" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7737" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7746" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7878" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_8292" - } ] + "definition" : { + "val" : "A notochord that has persisted beyond the embryonic stage.", + "xrefs" : [ "UBERON:cjm" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036244", "lbl" : "secretion of serous membrane", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A transudate found in the serous sac.", + "xrefs" : [ "FMA:20932" ] + }, + "xrefs" : [ { + "val" : "FMA:20932" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036253", "lbl" : "orifice of skull", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:53133" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036264", "lbl" : "zygomaticotemporal nerve", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit.", + "xrefs" : [ "Wikipedia:Zygomaticotemporal_nerve" ] + }, + "xrefs" : [ { + "val" : "FMA:52972" + }, { + "val" : "SCTID:280243001" + }, { + "val" : "Wikipedia:Zygomaticotemporal_nerve" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036285", "lbl" : "wall of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Wall of ventricle which is continuous with the wall of aorta.", + "xrefs" : [ "FMA:9556" ] + }, + "xrefs" : [ { + "val" : "FMA:9556" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036286", "lbl" : "wall of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Wall of ventricle which is continuous with the wall of pulmonary trunk.", + "xrefs" : [ "FMA:9533" ] + }, + "xrefs" : [ { + "val" : "FMA:9533" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036288", "lbl" : "anterior wall of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:9560" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036289", "lbl" : "anterior wall of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle.", + "xrefs" : [ "FMA:9553" ] + }, + "xrefs" : [ { + "val" : "FMA:9553" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036290", "lbl" : "myocardium of anterior wall of left ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:87177" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036291", "lbl" : "myocardium of anterior wall of right ventricle", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:260877" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036294", "lbl" : "mucosa of lip", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A mucosa that is part of a lip region [Automatically generated definition].", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "NCIT:C12226" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0036301", + "lbl" : "vasculature of spleen", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:225251" + }, { + "val" : "SCTID:297287005" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036302", "lbl" : "vasculature of central nervous system plus retina", @@ -23596,83 +84425,322 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036303", "lbl" : "vasculature of central nervous system", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:259905" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0036343", + "lbl" : "wall of gallbladder", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:14657" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036351", "lbl" : "wall of brachiocephalic artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:15089" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036352", "lbl" : "wall of subclavian artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:15090" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0036362", + "lbl" : "wall of anal canal", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:15704" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036422", "lbl" : "wall of pulmonary artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:18211" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036553", "lbl" : "wall of synovial tendon sheath", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:231590" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0036925", "lbl" : "wall of eyeball", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:58098" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "lbl" : "wall of orbit", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:63144" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0037094", "lbl" : "wall of common carotid artery", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:66284" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0037144", "lbl" : "wall of heart", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees.", + "xrefs" : [ "FMA:7274" ] + }, + "xrefs" : [ { + "val" : "FMA:7274" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "lbl" : "cystic artery", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An artery that supplies oxygenated blood to the cystic duct.", + "xrefs" : [ "http://orcid.org/0000-0002-6601-2165", "https://en.wikipedia.org/wiki/Cystic_artery" ] + }, + "xrefs" : [ { + "val" : "FMA:14835" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0039228", + "lbl" : "sigmoid vein", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:15395" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_0039261", + "lbl" : "pancreatic artery", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "FMA:70471" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0039856", "lbl" : "right ovarian vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament.", + "xrefs" : [ "FMA:14342" ] + }, + "xrefs" : [ { + "val" : "FMA:14342" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_0039857", "lbl" : "left ovarian vein", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament.", + "xrefs" : [ "FMA:14347" ] + }, + "xrefs" : [ { + "val" : "FMA:14347" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_1000021", "lbl" : "skin of face", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of the face.", + "xrefs" : [ "UBERON:EJS", "https://github.com/obophenotype/uberon/issues/34" ] + }, + "xrefs" : [ { + "val" : "EMAPA:36657" + }, { + "val" : "FMA:24758" + }, { + "val" : "NCIT:C33561" + }, { + "val" : "SCTID:361703006" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_1000024", + "lbl" : "parenchyma of spleen", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A parenchyma that is part of a spleen.", + "xrefs" : [ "OBOL:automatic" ] + }, + "xrefs" : [ { + "val" : "FMA:16029" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_1100000", "lbl" : "digestive tract junction", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junction between two parts of the digestive tract.", + "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_2001073", + "lbl" : "axial vasculature", + "type" : "CLASS", + "meta" : { + "xrefs" : [ { + "val" : "ZFA:0001073" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_2001457", "lbl" : "postcranial axial cartilage", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Cartilage which is part of the axial skeleton.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "ZFA:0001457" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_2005260", "lbl" : "fenestrated capillary", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse.", + "xrefs" : [ "Wikipedia:Capillary#Types", "Wikipedia:Fenestra_(histology)" ] + }, + "xrefs" : [ { + "val" : "FMA:63196" + }, { + "val" : "NCIT:C32595" + }, { + "val" : "TAO:0005260" + }, { + "val" : "Wikipedia:Capillary#Types" + }, { + "val" : "ZFA:0005260" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_2007013", "lbl" : "preplacodal ectoderm", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes.", + "xrefs" : [ "ZFIN:curator" ] + }, + "xrefs" : [ { + "val" : "ZFA:0007013" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_3000961", "lbl" : "external integument structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument.", + "xrefs" : [ "AAO:EJS" ] + }, + "comments" : [ "Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305" ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_3000972", "lbl" : "head external integument structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dermal, epidermal, glandular and pigment structures of the external head integument.", + "xrefs" : [ "AAO:EJS" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_3000977", "lbl" : "body external integument structure", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dermal, epidermal, glandular and pigment structures of the body integument.", + "xrefs" : [ "AAO:EJS" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_3000982", + "lbl" : "tail external integument structure", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Dermal, epidermal, glandular and pigment structures of the tail integument.", + "xrefs" : [ "AAO:EJS" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_3010200", "lbl" : "vasculature of respiratory integument", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Blood vessels in respiratory skin.", + "xrefs" : [ "AAO:EJS" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_4200230", "lbl" : "surface of bone", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical surface that is part of a bone.", + "xrefs" : [ "PHENOSCAPE" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_6000004", "lbl" : "panarthropod head", @@ -23680,100 +84748,368 @@ }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8000006", "lbl" : "left side of back", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.", + "xrefs" : [ "https://microbiomedb.org/" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8000007", "lbl" : "right side of back", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.", + "xrefs" : [ "https://microbiomedb.org/" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8000009", "lbl" : "Purkinje fiber network", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles.", + "xrefs" : [ "PMID:26786210" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8400021", + "lbl" : "liver serosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact.", + "xrefs" : [ "https://medical-dictionary.thefreedictionary.com/serosa+of+liver", "https://orcid.org/0000-0002-0449-2730" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8400023", + "lbl" : "liver subserosa", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson.", + "xrefs" : [ "FMA:15812", "https://medical-dictionary.thefreedictionary.com/subserosa+of+liver", "https://orcid.org/0000-0002-0449-2730" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410001", + "lbl" : "small intestine venule", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Venule of villus of small intestine.", + "xrefs" : [ "https://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410004", + "lbl" : "small intestine arteriole", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Arteriole of villus of small intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410008", + "lbl" : "venule of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A venule that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410009", + "lbl" : "arteriole of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arteriole that is located in the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410015", + "lbl" : "arteriole of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An arteriole located in the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410024", + "lbl" : "intestinal junction", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "An anatomical junction between two parts of the intestine.", + "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410043", + "lbl" : "bronchus submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosal gland located in a bronchus.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410048", + "lbl" : "venule of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A venule located in the colon.", + "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "lbl" : "anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus.", + "xrefs" : [ "DOI:10.1007/978-3-319-26938-2_8", "DOI:10.1148/rg.2015150037", "PMID:29742860", "http://orcid.org/0000-0002-6826-8770", "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410056", + "lbl" : "capillary of anorectum", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of the anorectum.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410057", + "lbl" : "capillary of colon", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of the colon.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410068", + "lbl" : "capillary of small intestine", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of a small intestine.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "lbl" : "airway submucosal gland", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A submucosal gland found in a respiratory tract.", + "xrefs" : [ "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ] + }, + "xrefs" : [ { + "val" : "EFO:0010666" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8410081", "lbl" : "blood microvessel", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins.", + "xrefs" : [ "Wikipedia:Microcirculation", "http://orcid.org/0000-0002-7073-9172" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8440015", "lbl" : "noradrenergic cell groups", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin).", + "xrefs" : [ "WikipediaVersioned:Noradrenergic_cell_groups&oldid=965992184" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8450002", "lbl" : "excretory system", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "An anatomical system that eliminates waste products that arise as a result of metabolic activity.", + "xrefs" : [ "GO:0007588" ] + } } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8480001", "lbl" : "capillary of brain", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A capillary that is part of the brain.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8480002", "lbl" : "thoracic aorta smooth muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A portion of smooth muscle tissue that is part of the thoracic aorta.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8480025", "lbl" : "skin of clavicle region", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is above the clavicle zone in the pectoral girdle region.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8480029", "lbl" : "skin of external genitalia", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin that is part of the external genitalia.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8480074", "lbl" : "skin of gonad", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A zone of skin part of some gonad.", + "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8600004", "lbl" : "visceral muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A muscle tissue that is associated with soft internal organs (viscera).", + "xrefs" : [ "BTO:0002780", "CLAO:0001295" ] + }, + "comments" : [ "It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated." ] + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8600006", "lbl" : "visceral striated muscle tissue", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A striated muscle tissue that is associated with soft internal organs (viscera).", + "xrefs" : [ "PMID:8720463", "https://pressbooks.pub/rbtallitsch/chapter/chapter-6-muscle-tissue/" ] + } + } + }, { + "id" : "http://purl.obolibrary.org/obo/UBERON_8600012", + "lbl" : "submucosal gland acinus", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium.", + "xrefs" : [ "PMID:17394068", "PMID:17707699", "PMID:25648514", "PMID:30864819" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8600017", "lbl" : "bronchopulmonary segment", "type" : "CLASS", "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/RO_0002175", - "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" - } ] + "definition" : { + "val" : "A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface.", + "xrefs" : [ "FMA:7312", "PMID:18271171", "PMID:33620799", "doi:10.1016/j.mpaic.2008.09.022" ] + }, + "comments" : [ "A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung." ] } }, { "id" : "http://purl.obolibrary.org/obo/UBERON_8600024", "lbl" : "pulmonary venule", - "type" : "CLASS" + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa.", + "xrefs" : [ "PMID:22283705", "PMID:30247823" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000050", "lbl" : "part of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "BFO:0000050" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000051", "lbl" : "has part", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "BFO:0000051" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000062", "lbl" : "preceded by", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "BFO:0000062" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000063", "lbl" : "precedes", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "BFO:0000063" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000066", "lbl" : "occurs in", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "BFO:0000066" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/BFO_0000067", "type" : "PROPERTY", @@ -23838,6 +85174,18 @@ "id" : "http://purl.obolibrary.org/obo/BSPO_0001107", "type" : "PROPERTY", "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "type" : "PROPERTY", + "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/BSPO_0005001", + "type" : "PROPERTY", + "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "type" : "PROPERTY", + "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/CL_4030045", "lbl" : "lacks_part", @@ -23852,27 +85200,52 @@ "id" : "http://purl.obolibrary.org/obo/GOREL_0002003", "lbl" : "results_in_distribution_of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "GOREL:0002003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GOREL_0002004", "lbl" : "results_in_fission_of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "GOREL:0002004" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0000053", "lbl" : "bearer of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0000053" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0000056", "lbl" : "participates in", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0000056" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0000057", "lbl" : "has participant", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0000057" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0000086", "type" : "PROPERTY", @@ -23897,7 +85270,12 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002007", "lbl" : "bounding layer of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002082", "type" : "PROPERTY", @@ -23906,7 +85284,12 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002087", "lbl" : "immediately preceded by", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002087" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002100", "type" : "PROPERTY", @@ -23923,7 +85306,12 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002131", "lbl" : "overlaps", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002131" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002134", "type" : "PROPERTY", @@ -23960,7 +85348,12 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002180", "lbl" : "has component", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002180" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002202", "type" : "PROPERTY", @@ -23973,27 +85366,52 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002211", "lbl" : "regulates", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002211" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002212", "lbl" : "negatively regulates", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002212" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002213", "lbl" : "positively regulates", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002213" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002215", "lbl" : "capable of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002215" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002216", "lbl" : "capable of part of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002216" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002219", "type" : "PROPERTY", @@ -24002,7 +85420,12 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002220", "lbl" : "adjacent to", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002220" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002221", "type" : "PROPERTY", @@ -24015,6 +85438,15 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002224", "lbl" : "starts with", "type" : "PROPERTY", + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002224" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0002226", + "type" : "PROPERTY", "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/RO_0002229", @@ -24024,17 +85456,32 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002230", "lbl" : "ends with", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002230" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002231", "lbl" : "has start location", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002231" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002232", "lbl" : "has end location", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002232" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002252", "type" : "PROPERTY", @@ -24059,66 +85506,136 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002295", "lbl" : "results in developmental progression of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002295" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002296", "lbl" : "results in development of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002296" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002297", "lbl" : "results in formation of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002297" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002298", "lbl" : "results in morphogenesis of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002298" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002299", "lbl" : "results in maturation of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002299" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002315", "lbl" : "results in acquisition of features of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002315" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002328", "type" : "PROPERTY", "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0002332", + "lbl" : "regulates levels of", + "type" : "PROPERTY", + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002332" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002338", "lbl" : "has target start location", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002338" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002339", "lbl" : "has target end location", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002339" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002341", "lbl" : "results in transport along", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002341" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002342", "lbl" : "results in transport across", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002342" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002343", "lbl" : "results in growth of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002343" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002344", "lbl" : "results in transport to from or in", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002344" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002351", "type" : "PROPERTY", @@ -24127,11 +85644,20 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002353", "lbl" : "output of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002353" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002371", "type" : "PROPERTY", "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0002372", + "type" : "PROPERTY", + "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/RO_0002373", "type" : "PROPERTY", @@ -24204,6 +85730,15 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002565", "lbl" : "results in movement of", "type" : "PROPERTY", + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002565" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0002568", + "type" : "PROPERTY", "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/RO_0002570", @@ -24221,56 +85756,116 @@ "id" : "http://purl.obolibrary.org/obo/RO_0002588", "lbl" : "results in assembly of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002588" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002590", "lbl" : "results in disassembly of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002590" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002592", "lbl" : "results in organization of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002592" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002608", "lbl" : "process has causal agent", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0002608" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0003000", "lbl" : "produces", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0003000" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0003001", "lbl" : "produced by", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0003001" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0004007", "lbl" : "has primary input or output", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0004007" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0004008", "lbl" : "has primary output", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0004008" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0004009", "lbl" : "has primary input", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0004009" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0012003", "lbl" : "acts on population of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0012003" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/RO_0012008", "lbl" : "results in fusion of", "type" : "PROPERTY", + "propertyType" : "OBJECT", + "meta" : { + "xrefs" : [ { + "val" : "RO:0012008" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/RO_0015004", + "lbl" : "has characterizing marker set", + "type" : "PROPERTY", "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/RO_0015015", @@ -24280,11 +85875,21 @@ "id" : "http://purl.obolibrary.org/obo/RO_0015016", "type" : "PROPERTY", "propertyType" : "OBJECT" + }, { + "id" : "http://purl.obolibrary.org/obo/so#member_of", + "type" : "PROPERTY", + "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#anteriorly_connected_to", "lbl" : "anteriorly connected to", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y.", + "xrefs" : [ "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#channel_for", "lbl" : "channel for", @@ -24304,12 +85909,24 @@ "id" : "http://purl.obolibrary.org/obo/uberon/core#distally_connected_to", "lbl" : "distally connected to", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y.", + "xrefs" : [ "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into", "lbl" : "extends_fibers_into", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y", + "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#filtered_through", "lbl" : "filtered through", @@ -24318,13 +85935,35 @@ "meta" : { "definition" : { "val" : "Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity." + }, + "comments" : [ "Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed" ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies", + "lbl" : "indirectly_supplies", + "type" : "PROPERTY", + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s." } } + }, { + "id" : "http://purl.obolibrary.org/obo/uberon/core#layer_part_of", + "lbl" : "layer part of", + "type" : "PROPERTY", + "propertyType" : "OBJECT" }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#posteriorly_connected_to", "lbl" : "posteriorly connected to", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y.", + "xrefs" : [ "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#protects", "lbl" : "protects", @@ -24334,7 +85973,13 @@ "id" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to", "lbl" : "proximally connected to", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "definition" : { + "val" : "x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y.", + "xrefs" : [ "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern" ] + } + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#site_of", "lbl" : "site_of", @@ -24349,7 +85994,10 @@ "id" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", "lbl" : "subdivision of", "type" : "PROPERTY", - "propertyType" : "OBJECT" + "propertyType" : "OBJECT", + "meta" : { + "comments" : [ "placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B" ] + } }, { "id" : "http://purl.obolibrary.org/obo/uberon/core#transitively_anteriorly_connected_to", "lbl" : "transitively anteriorly connected to", @@ -24373,10 +86021,6 @@ "id" : "http://purl.obolibrary.org/obo/IAO_0000700", "type" : "PROPERTY", "propertyType" : "ANNOTATION" - }, { - "id" : "http://purl.obolibrary.org/obo/RO_0002175", - "type" : "PROPERTY", - "propertyType" : "ANNOTATION" }, { "id" : "http://purl.obolibrary.org/obo/STATO_0000663", "type" : "PROPERTY", @@ -24412,8 +86056,73 @@ "lbl" : "title", "type" : "PROPERTY", "propertyType" : "ANNOTATION" + }, { + "id" : "http://www.geneontology.org/formats/oboInOwl#hasDbXref", + "lbl" : "database_cross_reference", + "type" : "PROPERTY", + "propertyType" : "ANNOTATION" + }, { + "id" : "http://www.w3.org/2000/01/rdf-schema#comment", + "type" : "PROPERTY", + "propertyType" : "ANNOTATION" } ], "edges" : [ { + "sub" : "http://identifiers.org/ensembl/ENSG00000038945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000050730", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000100292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000131471", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000137804", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000139329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000163735", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000164120", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000166803", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000168079", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000170323", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000171848", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000174807", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { + "sub" : "http://identifiers.org/ensembl/ENSG00000175063", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000704" + }, { "sub" : "http://purl.obolibrary.org/obo/CHEBI_24431", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/BFO_0000040" @@ -24425,6 +86134,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000000", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_131567" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000000", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037006" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000005", "pred" : "is_a", @@ -24881,6 +86594,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000082", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000083", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002076" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000083", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000084", "pred" : "is_a", @@ -25233,6 +86954,34 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000167", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0030072" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000168", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000154" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000168", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000167" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000168", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000169", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000168" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000169", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0008024" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000169", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000169", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0002351" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000170", "pred" : "is_a", @@ -25241,6 +86990,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000170", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0070091" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002067" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0008024" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000171", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0002351" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000172", "pred" : "is_a", @@ -25249,6 +87014,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000172", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0070253" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000173", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000502" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000173", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0008024" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000173", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000173", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0002351" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000174", "pred" : "is_a", @@ -25257,6 +87038,34 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000174", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0035929" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000066" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000417" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0005026" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000182", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0098754" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000183", "pred" : "is_a", @@ -25521,6 +87330,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000313", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000319", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000319", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0070254" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000322", "pred" : "is_a", @@ -25633,6 +87450,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000355", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000188" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000358", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000192" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000358", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000359", "pred" : "is_a", @@ -25697,6 +87522,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000404", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000211" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000412", + "pred" : "http://purl.obolibrary.org/obo/RO_0000053", + "obj" : "http://purl.obolibrary.org/obo/PATO_0001377" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000413", "pred" : "is_a", @@ -25705,6 +87538,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000413", "pred" : "http://purl.obolibrary.org/obo/RO_0000053", "obj" : "http://purl.obolibrary.org/obo/PATO_0001375" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000417", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000412" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000447", "pred" : "is_a", @@ -25793,6 +87630,46 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000499", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_0000134" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000502", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000164" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000502", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000172" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000506", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000507" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000507", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000167" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000164" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000506" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000509" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002180" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000508", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004997" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000509", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000167" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000513", "pred" : "is_a", @@ -26369,6 +88246,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000583", "pred" : "http://purl.obolibrary.org/obo/RO_0002104", "obj" : "http://purl.obolibrary.org/obo/PR_000002972" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000583", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037003" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000583", "pred" : "http://purl.obolibrary.org/obo/RO_0015016", @@ -26397,10 +88278,30 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0000604", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_0002672" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000622", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000150" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000622", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000154" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000622", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009842" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000630", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000666", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0000666", + "pred" : "http://purl.obolibrary.org/obo/RO_0000053", + "obj" : "http://purl.obolibrary.org/obo/PATO_0002064" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0000667", "pred" : "is_a", @@ -28105,6 +90006,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002063", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_4040003" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000622" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001599" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002064", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001263" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002064", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/GO_0042589" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002067", "pred" : "is_a", @@ -28169,6 +90086,34 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002078", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_0000222" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002079", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000069" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002079", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001433" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002079", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001064" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002079", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0015106" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002080", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001433" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002080", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001263" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002080", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0015106" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002086", "pred" : "is_a", @@ -28181,6 +90126,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002087", "pred" : "http://purl.obolibrary.org/obo/CL_4030045", "obj" : "http://purl.obolibrary.org/obo/GO_0030141" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002088", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000710" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002088", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0043134" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002092", "pred" : "is_a", @@ -28289,6 +90242,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002194", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0030224" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002195", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000048" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002195", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002202", "pred" : "is_a", @@ -28353,6 +90314,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002242", "pred" : "http://purl.obolibrary.org/obo/RO_0000053", "obj" : "http://purl.obolibrary.org/obo/PATO_0002505" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002243", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000358" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002243", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001607" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002243", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0000133" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002246", "pred" : "is_a", @@ -28381,6 +90354,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002252", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002253", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002254", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002254", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002262", "pred" : "is_a", @@ -28397,6 +90386,42 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002264", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0002659" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002265", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000502" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002265", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0009042" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002266", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000502" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002266", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0009006" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002267", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000502" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002267", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002659" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000696" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0008024" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002275", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000006" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002308", "pred" : "is_a", @@ -28461,6 +90486,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002350", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002165" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002351", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0011026" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002352", "pred" : "is_a", @@ -28597,6 +90626,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002503", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005742" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002504", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000192" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002504", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002521", "pred" : "is_a", @@ -28605,6 +90642,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002521", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002190" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002538", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002538", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004823" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002539", "pred" : "is_a", @@ -28677,6 +90722,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002557", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002012" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002563", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002251" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002563", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001277" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002570", "pred" : "is_a", @@ -28685,6 +90738,34 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002570", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001013" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002571", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000134" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002571", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002195" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002572", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000134" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002572", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0001035" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002572", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000499" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002574", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002575", "pred" : "is_a", @@ -28829,6 +90910,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002657", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0002252" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002658", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000150" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002658", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002253" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0002659", "pred" : "is_a", @@ -28873,6 +90962,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0002676", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/CL_0000333" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002680", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000696" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0002680", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001516" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0005000", "pred" : "is_a", @@ -28885,6 +90982,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0005012", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000067" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0005026", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000048" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0007001", "pred" : "is_a", @@ -28985,6 +91086,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0008022", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002062" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0008024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000083" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0008024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000164" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0008028", "pred" : "is_a", @@ -29029,6 +91138,130 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0009004", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005388" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009006", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001516" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009006", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001598" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009018", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000542" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009018", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011189" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000499" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009021", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011189" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009022", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000499" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009022", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001238" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002254" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009025", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009025", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0011108" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009038", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000235" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009038", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009040", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0009021" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009040", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007177" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009042", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001516" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009042", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001588" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009044", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000542" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009044", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001238" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009048", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000235" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009048", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009051", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000084" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009051", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009052", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000279" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009052", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009053", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0009021" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009053", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009063", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002658" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009063", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001516" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009063", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0009089", "pred" : "is_a", @@ -29037,6 +91270,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0009089", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002048" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009094", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002543" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009094", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001639" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0009097", "pred" : "is_a", @@ -29045,6 +91286,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0009097", "pred" : "http://purl.obolibrary.org/obo/RO_0002491", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000068" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009100", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000057" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0009100", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001279" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0010001", "pred" : "is_a", @@ -29229,6 +91478,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0011030", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_2000010" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0011108", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002253" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0011108", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000397" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0011115", "pred" : "is_a", @@ -29301,6 +91558,30 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0019019", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007196" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019020", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019020", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004822" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000398" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019021", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001279" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019022", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000398" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0019022", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006841" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000222", "pred" : "is_a", @@ -29365,6 +91646,54 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1000274", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000349" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002504" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000275", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000276", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000275" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000276", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000279", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002504" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000279", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000280", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000279" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000280", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000285", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000280" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000285", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000286", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000279" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000286", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000303", "pred" : "is_a", @@ -29489,6 +91818,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1000376", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002094" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000398", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000666" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000398", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002262" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000398", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001281" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000409", "pred" : "is_a", @@ -29541,6 +91882,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1000414", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001979" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000415", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000066" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000415", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000428", "pred" : "is_a", @@ -29609,6 +91958,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1000482", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002094" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000488", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/BFO_0000002" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000488", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000069" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000488", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1000488", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/CL_0005026" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1000490", "pred" : "is_a", @@ -29641,6 +92006,22 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1000493", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002401" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001433", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000083" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001433", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001516", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000164" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001516", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1001567", "pred" : "is_a", @@ -29657,6 +92038,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1001568", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005317" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001572", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001572", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013695" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1001576", "pred" : "is_a", @@ -29669,6 +92058,70 @@ "sub" : "http://purl.obolibrary.org/obo/CL_1001576", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002424" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001588", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002658" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001588", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0011108" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001589", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001598" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001589", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008346" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001592", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000150" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001592", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1000415" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001592", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002029" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001595", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002658" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001595", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003354" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001598", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000150" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001598", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002254" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001598", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001902" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001599", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000150" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001599", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000152" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001599", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_1001433" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_1001599", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013697" }, { "sub" : "http://purl.obolibrary.org/obo/CL_1001603", "pred" : "is_a", @@ -29829,6 +92282,30 @@ "sub" : "http://purl.obolibrary.org/obo/CL_2000047", "pred" : "http://purl.obolibrary.org/obo/RO_0002100", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002298" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000051", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000057" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000051", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000053", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000053", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000055", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000451" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000055", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/CL_2000063", "pred" : "is_a", @@ -29869,6 +92346,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_2000068", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002407" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000069", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000057" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000069", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/CL_2000070", "pred" : "is_a", @@ -29897,6 +92382,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_2000073", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000095" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000074", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000738" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_2000074", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/CL_2000080", "pred" : "is_a", @@ -29985,6 +92478,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4028004", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002299" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4028004", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037002" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4028006", "pred" : "is_a", @@ -29997,6 +92494,10 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4028006", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002299" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4028006", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037001" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4030029", "pred" : "is_a", @@ -30021,6 +92522,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4030034", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004802" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033005", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000152" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033005", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0019001" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033005", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410043" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4033008", "pred" : "is_a", @@ -30049,6 +92562,46 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4033018", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000114" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033020", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000307" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033020", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_4033037" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033020", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005203" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033022", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002328" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033022", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_4033037" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033022", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410043" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033037", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000152" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033037", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000319" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033037", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002202" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033037", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410077" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4033041", "pred" : "is_a", @@ -30057,10 +92610,18 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4033041", "pred" : "http://purl.obolibrary.org/obo/RO_0002292", "obj" : "http://purl.obolibrary.org/obo/PR_000002123" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033041", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037004" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4033042", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/CL_0000583" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033042", + "pred" : "http://purl.obolibrary.org/obo/RO_0015004", + "obj" : "http://purl.obolibrary.org/obo/CL_4037005" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4033054", "pred" : "is_a", @@ -30069,6 +92630,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_4033054", "pred" : "http://purl.obolibrary.org/obo/RO_0002220", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033061", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0002543" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_4033061", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006841" }, { "sub" : "http://purl.obolibrary.org/obo/CL_4037001", "pred" : "is_a", @@ -30165,6 +92734,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0000271", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18154" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0000272", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0000272", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18154" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0000278", "pred" : "is_a", @@ -30417,6 +92994,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0001654", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000970" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001655", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048731" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001655", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/GO_0072001" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001655", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004122" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0001659", "pred" : "is_a", @@ -30453,6 +93042,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0001677", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0044207" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001678", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019725" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001678", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0001696", "pred" : "is_a", @@ -30969,6 +93566,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0001886", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/CL_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001889", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048732" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001889", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0001889", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0001894", "pred" : "is_a", @@ -31329,6 +93938,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0002250", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0002251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006955" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0002252", "pred" : "is_a", @@ -31545,6 +94158,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0002376", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0002384", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0002384", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0002384", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0002396", "pred" : "is_a", @@ -32833,6 +95458,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0003013", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0003008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003014", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003008" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0003015", "pred" : "is_a", @@ -33365,6 +95994,42 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0003221", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003381" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055010" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061384" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003222", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004126" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003225", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003220" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003225", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003222" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003225", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005064" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003221" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003222" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003227", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005066" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0003228", "pred" : "is_a", @@ -33601,6 +96266,54 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0003301", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0055017" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003309", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0035883" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003309", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031018" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003309", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0000169" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003310", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0035883" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003310", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031018" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003310", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0000171" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003311", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0035883" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003311", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031018" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003311", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0000173" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003312", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0035883" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003312", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031018" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003312", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0002275" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0003313", "pred" : "is_a", @@ -33641,6 +96354,54 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0003315", "pred" : "http://purl.obolibrary.org/obo/RO_0002297", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004291" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003322", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002068" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003322", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003310" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003322", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/CL_0000171" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003323", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002068" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003323", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003309" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003323", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/CL_0000169" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003324", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002068" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003324", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003311" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003324", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/CL_0000173" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003325", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002068" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003325", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003312" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003325", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/CL_0002275" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0003341", "pred" : "is_a", @@ -33877,6 +96638,82 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0003433", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0003413" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003674", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/BFO_0000015" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0003824", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0004518", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0016788" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0004536", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0004518" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0004536", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140097" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0004536", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0006259" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005215", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005275", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0015837" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005275", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_32952" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005319", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005319", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0006869" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005319", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005342", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_1903825" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005342", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005355", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005355", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_1904659" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005355", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0005575", "pred" : "is_a", @@ -34205,6 +97042,82 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0005976", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18154" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005977", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005975" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005977", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006112" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005977", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005977", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_28087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005978", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005977" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005978", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009250" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005978", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_28087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005979", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010962" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005979", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070873" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005979", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0005978" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005980", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005980", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_28087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005981", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043470" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005981", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070873" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0005981", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0005980" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006006", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019318" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006006", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006007", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006007", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006024", "pred" : "is_a", @@ -34213,6 +97126,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006024", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006027", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006027", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006082", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044237" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006082", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006082", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006091", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044237" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006094", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006094", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006109", "pred" : "is_a", @@ -34221,6 +97166,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006109", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0005975" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006111", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006111", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006094" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0015980" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006139", "pred" : "is_a", @@ -34237,6 +97194,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006259", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006308", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006308", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/GO_0004536" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006308", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006309", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006308" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006309", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0030262" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006325", "pred" : "is_a", @@ -34245,6 +97222,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006325", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", "obj" : "http://purl.obolibrary.org/obo/GO_0000785" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006401", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006401", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33697" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006403", "pred" : "is_a", @@ -34345,6 +97330,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006449", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0006415" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006516", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006516", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17089" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006518", "pred" : "is_a", @@ -34377,6 +97370,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006629", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006694", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006694", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008610" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006694", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35341" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008206" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0072330" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1901617" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36235" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006706", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006706", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35341" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006810", "pred" : "is_a", @@ -34417,6 +97454,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0006869", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006873", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019725" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006873", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_24867" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006886", "pred" : "is_a", @@ -34833,6 +97878,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007034", "pred" : "http://purl.obolibrary.org/obo/RO_0002344", "obj" : "http://purl.obolibrary.org/obo/GO_0005773" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007039", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007039", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0005773" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0007040", "pred" : "is_a", @@ -35277,6 +98330,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007440", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007442", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009653" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007442", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0048546" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007442", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061525" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007442", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0007492", "pred" : "is_a", @@ -35285,6 +98354,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007492", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000925" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007494", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007494", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0007498", "pred" : "is_a", @@ -35393,6 +98470,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007586", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0032501" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007588", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007589", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046903" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007589", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050878" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0007600", "pred" : "is_a", @@ -35409,6 +98498,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007606", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0007600" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007610", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032501" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007610", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007610", + "pred" : "http://purl.obolibrary.org/obo/RO_0002608", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001016" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007626", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007610" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008015", "pred" : "is_a", @@ -35453,6 +98558,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0008152", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008202", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006629" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008202", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35341" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008206", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008206", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032787" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008206", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1901615" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008206", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36235" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008219", "pred" : "is_a", @@ -35485,6 +98614,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0008285", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0008283" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008320", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008320", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140318" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008320", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0071806" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008347", "pred" : "is_a", @@ -35577,6 +98718,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0008643", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008645", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008645", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009056", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009057", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009057", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33694" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009058", "pred" : "is_a", @@ -35609,6 +98770,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009101", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_17089" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009250", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0000271" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009250", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009250", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_37163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009251", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_37163" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009306", "pred" : "is_a", @@ -35637,6 +98818,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009309", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_32952" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009310", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009310", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_32952" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009314", "pred" : "is_a", @@ -35733,6 +98922,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009628", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0050896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009636", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042221" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009653", "pred" : "is_a", @@ -35773,6 +98966,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009743", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009746", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009746", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009749", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009749", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009786", "pred" : "is_a", @@ -35897,6 +99106,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009893", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019222" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009894", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009895", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009892" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009895", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009895", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009896", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009893" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009896", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009896", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009913", "pred" : "is_a", @@ -36289,6 +99530,42 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010564", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0022402" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010565", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010565", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010565", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0042180" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010566", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010566", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031326" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010566", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0042181" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010567", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031329" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010567", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010567", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0042182" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010594", "pred" : "is_a", @@ -36721,6 +99998,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010701", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0048243" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010710", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010710", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0030574" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010711", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010711", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010710" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010711", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0030574" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010712", "pred" : "is_a", @@ -36985,6 +100282,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010820", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0010818" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010827", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034762" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010827", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1904659" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010828", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010827" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010828", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034764" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010828", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1904659" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010829", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010827" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010829", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034763" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010829", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1904659" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010830", "pred" : "is_a", @@ -37041,6 +100370,58 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010876", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010893", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045940" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010893", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010893", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010893", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051055" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010894", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010906", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006109" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010906", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006006" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010907", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010906" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010907", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045913" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010907", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006006" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010927", "pred" : "is_a", @@ -37117,6 +100498,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0010948", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0022402" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010962", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032885" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0010962", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0009250" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010968", "pred" : "is_a", @@ -37597,6 +100986,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0014819", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0003009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0014821", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0014827", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0014821" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0014827", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0014831" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0014831", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006939" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0014855", "pred" : "is_a", @@ -37789,6 +101194,82 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0015031", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0045184" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015075", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015075", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0034220" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015075", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_24867" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015106", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015106", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0015701" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015106", + "pred" : "http://purl.obolibrary.org/obo/RO_0000057", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17544" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015106", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17544" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015125", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015125", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0015721" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015125", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_3098" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015144", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015144", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0034219" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015144", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015149", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015149", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0008645" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015149", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015159", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0015774" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015159", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18154" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0015629", "pred" : "is_a", @@ -37809,6 +101290,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0015671", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_15379" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015701", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015701", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17544" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015718", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046942" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015718", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006869" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0015718" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0015850" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015721", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_3098" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0015774", "pred" : "is_a", @@ -37837,6 +101350,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0015837", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_32952" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015849", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015849", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0015850", "pred" : "is_a", @@ -37877,10 +101398,34 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0015931", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_61120" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015932", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015932", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0015931" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015932", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_61120" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0015980", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006091" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0016020", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0110165" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016042", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016042", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0016043", "pred" : "is_a", @@ -37917,6 +101462,46 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0016051", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016052", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016052", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016053", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006082" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016053", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044249" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016053", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044283" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016053", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016054", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006082" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016054", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016054", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044282" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016054", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_64709" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0016057", "pred" : "is_a", @@ -38009,6 +101594,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0016528", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/CL_0000187" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016787", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0016788", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0016787" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0017126", "pred" : "is_a", @@ -38065,6 +101658,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0018958", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33853" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019098", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007610" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019098", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048609" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019216", "pred" : "is_a", @@ -38073,6 +101674,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0019216", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0006629" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019218", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019216" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019218", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0008202" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019219", "pred" : "is_a", @@ -38121,6 +101730,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0019233", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0007600" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019318", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019318", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019319", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019319", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019320", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019320", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019336", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019336", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33853" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019538", "pred" : "is_a", @@ -38129,6 +101770,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0019538", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/PR_000000001" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019614", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019614", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33566" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019725", "pred" : "is_a", @@ -38141,6 +101790,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0019725", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_131567" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019752", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043436" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0019752", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0019867", "pred" : "is_a", @@ -39113,6 +102770,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0022618", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_1990904" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022857", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022857", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0055085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022857", + "pred" : "http://purl.obolibrary.org/obo/RO_0002342", + "obj" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022884", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022884", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022898", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032409" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022898", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034762" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0022898", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0023019", "pred" : "is_a", @@ -39269,6 +102958,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0030072", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_25905" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030073", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009306" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030073", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030072" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030073", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030073", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000009054" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030097", "pred" : "is_a", @@ -39349,6 +103054,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0030155", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0007155" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030163", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030163", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000000001" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030182", "pred" : "is_a", @@ -39409,6 +103122,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0030213", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16336" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030214", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030214", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16336" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030217", "pred" : "is_a", @@ -39653,6 +103374,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0030397", "pred" : "http://purl.obolibrary.org/obo/RO_0002590", "obj" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030421", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007588" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030421", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022600" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030432", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0014821" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030473", "pred" : "is_a", @@ -39673,6 +103406,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0030485", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/CL_0000192" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030573", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030573", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36235" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030574", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/GO_0005581" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030595", "pred" : "is_a", @@ -39965,6 +103714,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0031012", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0030312" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031016", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048513" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048732" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031016" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0035272" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0055123" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031017", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031018", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031018", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031016" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031018", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0035270" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031018", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000016" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0031022", "pred" : "is_a", @@ -40333,6 +104126,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0031328", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0044249" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031329", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031324" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031329" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031330", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031325" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031329" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031331", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0031333", "pred" : "is_a", @@ -40585,6 +104422,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0031982", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0043227" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031987", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0040011" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0031987", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0007626" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050714" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050796" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0090277" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032024", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032057", "pred" : "is_a", @@ -40613,6 +104474,94 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032060", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0032059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032069", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051336" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032069", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060255" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032069", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0004518" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032070", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032069" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032070", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051052" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032070", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0004536" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032074", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032069" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032074", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045934" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032074", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051346" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032074", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0004518" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032075", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032069" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032075", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045935" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032075", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051345" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032075", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0004518" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032070" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032074" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051053" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032076", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0004536" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032070" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032075" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032077", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0004536" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032101", "pred" : "is_a", @@ -40829,6 +104778,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032332", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0002062" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032364", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055082" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032364", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_15379" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032365", "pred" : "is_a", @@ -40969,6 +104926,86 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032388", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0046907" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032409", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0065009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032409", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032410", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032409" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032410", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044092" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032410", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051051" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032410", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032411", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032409" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032411", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044093" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032411", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051050" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032411", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022898" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032412", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0015075" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032410" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032412" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034766" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032413", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0015075" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032414", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032411" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032414", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032412" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032414", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034767" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032414", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0015075" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032418", "pred" : "is_a", @@ -41061,6 +105098,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032774", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33697" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032782", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046717" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032782", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36235" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032787", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019752" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032787", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032790", "pred" : "is_a", @@ -41077,6 +105130,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032838", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0120025" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032868", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042221" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032868", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043434" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032868", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000009054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032869", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032868" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032869", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0071375" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032871", "pred" : "is_a", @@ -41145,6 +105218,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032886", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0007017" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032890", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051049" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032890", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0015849" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032891", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032890" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032891", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051051" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032891", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0015849" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032892", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032890" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032892", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051050" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032892", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0015849" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032940", "pred" : "is_a", @@ -41153,6 +105258,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0032940", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0140352" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032941", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032501" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0032941", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046903" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0032943", "pred" : "is_a", @@ -41501,6 +105614,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0033240", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0009308" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033241", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033241", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0009310" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033242", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033242", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0033241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033242", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0009310" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033243", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033243", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0033241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033243", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0009310" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0033278", "pred" : "is_a", @@ -41549,6 +105694,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0033371", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/CL_0000084" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033500", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0033500", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16646" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0033604", "pred" : "is_a", @@ -41717,6 +105870,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0034250", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0043603" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034251", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0043605" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034252", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0043605" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0034251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034253", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0043605" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0034329", "pred" : "is_a", @@ -41853,6 +106038,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0034654", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_61120" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034655", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0034655", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_61120" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0034762", "pred" : "is_a", @@ -42225,6 +106418,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0035592", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0071692" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035622", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035622", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035622", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003704" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035628", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035628", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035645", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051145" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035645", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0048565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035645", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0002504" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0035701", "pred" : "is_a", @@ -42269,6 +106494,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0035767", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0060326" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035773", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035773", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0071333" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035774", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032024" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035774", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061178" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035774", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0035773" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0035779", "pred" : "is_a", @@ -42293,6 +106538,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0035805", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035844", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035844", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001655" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035844", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0048546" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0035844", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0035855", "pred" : "is_a", @@ -42577,6 +106838,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0036293", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0070482" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036333", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048872" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036333", + "pred" : "http://purl.obolibrary.org/obo/RO_0012003", + "obj" : "http://purl.obolibrary.org/obo/CL_0000182" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0036334", "pred" : "is_a", @@ -42593,6 +106862,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0036336", "pred" : "http://purl.obolibrary.org/obo/RO_0002565", "obj" : "http://purl.obolibrary.org/obo/CL_0000451" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009653" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036342", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036342", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0036477", "pred" : "is_a", @@ -42961,6 +107242,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042158", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_6495" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042159", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_6495" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042175", "pred" : "is_a", @@ -42969,6 +107258,66 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042175", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0012505" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042176", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042176", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042177", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042177", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042176" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042177", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042180", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044237" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042180", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042180", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042181", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042180" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042181", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044249" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042181", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044283" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042181", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042182", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042182", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044282" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042182", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17087" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042221", "pred" : "is_a", @@ -43013,6 +107362,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042401", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0009309" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042402", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009310" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042415", "pred" : "is_a", @@ -43029,6 +107382,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042421", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_72587" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042422", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042422", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_72587" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042423", "pred" : "is_a", @@ -43037,6 +107398,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042423", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33567" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042424", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042402" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042424", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33567" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042427", "pred" : "is_a", @@ -43065,6 +107434,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042428", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_350546" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042429", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042429", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_350546" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042430", "pred" : "is_a", @@ -43085,6 +107462,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042435", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_24828" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042436", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042436", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_24828" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042461", "pred" : "is_a", @@ -43169,10 +107554,34 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042582", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0030141" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042588", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030141" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042589", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030667" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042589", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0042588" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042589", + "pred" : "http://purl.obolibrary.org/obo/RO_0002007", + "obj" : "http://purl.obolibrary.org/obo/GO_0042588" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042592", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042593", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042593", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042611", "pred" : "is_a", @@ -43225,6 +107634,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0042886", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_32988" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042887", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042887", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0042886" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0042887", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_32988" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0042953", "pred" : "is_a", @@ -43477,10 +107898,58 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0043073", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/CL_0000586" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043085", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044093" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043085", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050790" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043085", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043086", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044092" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043086", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050790" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043086", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043129", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0048871" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043133", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043133", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022600" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043133", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043134", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006940" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043134", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044058" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043134", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0043133" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043143", "pred" : "is_a", @@ -43501,6 +107970,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0043170", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044248" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043171", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_60466" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043207", "pred" : "is_a", @@ -43721,6 +108198,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0043434", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_25905" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043436", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006082" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043436", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35406" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043467", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043467", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006091" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043470", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043470", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0016052" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043473", "pred" : "is_a", @@ -43889,6 +108390,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0043604", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_32988" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043605", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0043605", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_32988" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0043931", "pred" : "is_a", @@ -43913,6 +108422,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0043933", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", "obj" : "http://purl.obolibrary.org/obo/GO_0032991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044042", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044042", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_37163" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044057", "pred" : "is_a", @@ -43937,6 +108454,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0044060", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0050886" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044062", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044062", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051046" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044062", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0007588" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044065", "pred" : "is_a", @@ -44001,6 +108530,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0044091", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044092", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0065009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044092", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0003674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044093", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0065009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044093", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0003674" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044207", "pred" : "is_a", @@ -44021,6 +108566,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0044238", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044248", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044248", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044237" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044249", "pred" : "is_a", @@ -44029,6 +108582,34 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0044249", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0044237" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044258", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0016042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044258", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044282", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044282", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044283", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044283", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044297", "pred" : "is_a", @@ -44037,6 +108618,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0044297", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050673" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044342", + "pred" : "http://purl.obolibrary.org/obo/RO_0012003", + "obj" : "http://purl.obolibrary.org/obo/CL_0000169" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044346", "pred" : "is_a", @@ -44917,6 +109506,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0045687", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0010001" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045719", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005979" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045719", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010558" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045719", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070874" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045719", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0005978" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006111" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031327" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045721", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045912" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045721", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006094" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045722", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006111" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045722", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031328" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045722", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006094" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0045724", "pred" : "is_a", @@ -44933,6 +109566,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0045724", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0060271" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045725", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005979" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045725", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010557" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045725", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070875" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045725", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0005978" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0045727", "pred" : "is_a", @@ -44949,6 +109598,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0045727", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0006412" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045732", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045732", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042176" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045732", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0045759", "pred" : "is_a", @@ -45125,6 +109786,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0045807", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0006897" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045818", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005981" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045818", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031330" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045818", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070874" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045818", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0005980" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045819", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005981" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045819", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031331" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045819", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070875" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045819", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0005980" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0045822", "pred" : "is_a", @@ -45505,6 +110198,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0045935", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0006139" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045939", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019218" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045939", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045833" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045939", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0008202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045940", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019218" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045940", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045834" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0045940", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0008202" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0045947", "pred" : "is_a", @@ -45629,6 +110346,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0046189", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33853" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0016053" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019752" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046394", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046395", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0016054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046395", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046530", "pred" : "is_a", @@ -45877,6 +110614,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0046673", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0046667" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046676", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050709" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046676", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050796" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046676", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0090278" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046676", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0046716", "pred" : "is_a", @@ -46061,6 +110814,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0046907", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/GO_0005622" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046942", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046942", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046943", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046943", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_1905039" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0046943", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_29067" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0047496", "pred" : "is_a", @@ -46613,6 +111386,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0048519", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048520", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050795" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048520", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048520", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0007610" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048521", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050795" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048521", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048521", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0007610" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0048522", "pred" : "is_a", @@ -46645,6 +111442,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0048534", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0002520" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048536", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048534" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048536", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0048539", "pred" : "is_a", @@ -47597,6 +112402,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0048873", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0048872" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048878", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042592" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0048878", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_24431" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0048880", "pred" : "is_a", @@ -48001,6 +112814,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050789", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050790", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0065009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050790", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0050793", "pred" : "is_a", @@ -48017,6 +112838,34 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050794", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0009987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050795", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051239" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050795", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0007610" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050796", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050708" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050796", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0090276" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050796", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050801", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050801", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_24867" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0050803", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", @@ -48081,6 +112930,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050808", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", "obj" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050810", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019218" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050810", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046890" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050810", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006694" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0050832", "pred" : "is_a", @@ -48205,6 +113066,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050886", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0003008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050890", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050877" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0050896", "pred" : "is_a", @@ -48389,6 +113254,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0050975", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0050954" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050994", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050994", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0016042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050995", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050995", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050994" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050995", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0016042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050996", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050996", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050994" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0050996", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0016042" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051017", "pred" : "is_a", @@ -48409,6 +113306,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0051027", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051033", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051033", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0050658" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051033", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33697" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051035", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051035", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0051027" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051035", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051046", "pred" : "is_a", @@ -48981,6 +113902,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0051321", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2759" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051336", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050790" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051336", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0016787" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051345", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051345", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051336" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051345", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0016787" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051346", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043086" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051346", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051336" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051346", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0016787" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051402", "pred" : "is_a", @@ -48989,6 +113942,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0051402", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/CL_0000540" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051410", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0098754" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051410", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_1901698" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0051410", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_51143" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0051445", "pred" : "is_a", @@ -49897,6 +114862,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0055059", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0055057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0055082", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019725" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0055082", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0055085", "pred" : "is_a", @@ -49909,6 +114882,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0055085", "pred" : "http://purl.obolibrary.org/obo/RO_0002342", "obj" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0055088", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0055088", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0055094", "pred" : "is_a", @@ -49989,6 +114970,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0055123", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001007" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060021", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007375" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0060037", "pred" : "is_a", @@ -50541,6 +115530,62 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0060341", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0051641" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060343", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048646" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060343", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0009887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060343", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061383" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060343", + "pred" : "http://purl.obolibrary.org/obo/RO_0002297", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060344", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060343" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060344", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060344", + "pred" : "http://purl.obolibrary.org/obo/RO_0002297", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010183" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060345", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060343" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060345", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0048536" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060345", + "pred" : "http://purl.obolibrary.org/obo/RO_0002297", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001265" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060343" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060347", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003206" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060347", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061384" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060347", + "pred" : "http://purl.obolibrary.org/obo/RO_0002297", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0060348", "pred" : "is_a", @@ -50909,6 +115954,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0060441", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0060425" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060450", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043134" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060450", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060450", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060456" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060450", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0043133" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060451", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043134" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060451", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045986" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060451", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060457" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060451", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0043133" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0060452", "pred" : "is_a", @@ -51401,6 +116478,42 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0060572", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005153" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002069" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060574", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0060576" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060574", + "pred" : "http://purl.obolibrary.org/obo/RO_0002299", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060575", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002065" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060575", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0048565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060575", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060576", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002066" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060576", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0060575" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0060576", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0060577", "pred" : "is_a", @@ -51961,6 +117074,66 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0060986", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0050886" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061007", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048731" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061008", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061009", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0035295" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061009", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061009", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061010", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048513" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061010", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061008" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061010", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061011", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061009" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061011", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030855" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048863" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061017", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061024", "pred" : "is_a", @@ -52381,6 +117554,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061111", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0060684" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061113", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0031016" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061113", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061138" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061114", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061113" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061117", "pred" : "is_a", @@ -52393,6 +117586,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061117", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0060419" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061130", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048645" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061130", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061114" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061130", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0072175" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061130", + "pred" : "http://purl.obolibrary.org/obo/RO_0002297", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003922" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061138", "pred" : "is_a", @@ -52449,6 +117658,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061152", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061153", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048732" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061153", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0061152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061153", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005203" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061154", "pred" : "is_a", @@ -52481,6 +117702,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061156", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061178", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050796" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061178", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0035773" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061179", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046676" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061179", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048585" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061179", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061178" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061179", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0035773" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061181", "pred" : "is_a", @@ -52673,6 +117918,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061351", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008283" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061383", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009653" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061383", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061384", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061383" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061384", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061385", "pred" : "is_a", @@ -52701,6 +117962,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061450", "pred" : "http://purl.obolibrary.org/obo/RO_0002565", "obj" : "http://purl.obolibrary.org/obo/CL_0000351" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061453", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060563" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061453", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060575" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061453", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0002088" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061458", "pred" : "is_a", @@ -52717,6 +117990,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061462", "pred" : "http://purl.obolibrary.org/obo/RO_0002339", "obj" : "http://purl.obolibrary.org/obo/GO_0005764" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061469", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050678" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061469", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0044342" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061484", "pred" : "is_a", @@ -52769,6 +118050,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061523", "pred" : "http://purl.obolibrary.org/obo/RO_0002590", "obj" : "http://purl.obolibrary.org/obo/GO_0005929" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061525", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061525", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061548", "pred" : "is_a", @@ -52945,6 +118234,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061572", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", "obj" : "http://purl.obolibrary.org/obo/GO_0032432" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061580", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061582" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061580", + "pred" : "http://purl.obolibrary.org/obo/RO_0002565", + "obj" : "http://purl.obolibrary.org/obo/CL_0011108" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061581", "pred" : "is_a", @@ -52953,6 +118250,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061581", "pred" : "http://purl.obolibrary.org/obo/RO_0002565", "obj" : "http://purl.obolibrary.org/obo/CL_0000575" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061582", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010631" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0061582", + "pred" : "http://purl.obolibrary.org/obo/RO_0002565", + "obj" : "http://purl.obolibrary.org/obo/CL_0002563" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0061626", "pred" : "is_a", @@ -53061,6 +118366,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0061973", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007842" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062012", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019222" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062012", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062013", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009893" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062013", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062013", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062014", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009892" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062014", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0062014", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0044281" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0062023", "pred" : "is_a", @@ -53149,6 +118486,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0065007", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0065009", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0065007" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0065009", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0003674" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0065010", "pred" : "is_a", @@ -53345,6 +118690,66 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0070253", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CHEBI_64628" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070254", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007589" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070254", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032941" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070254", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000912" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070255", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070255", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051046" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070255", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051239" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070255", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0070254" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070256", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051048" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070256", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070256", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070255" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070256", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0070254" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070257", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051047" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070257", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070257", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070255" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070257", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0070254" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0070285", "pred" : "is_a", @@ -53397,6 +118802,58 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0070346", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0070341" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070365", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030855" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070365", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070365", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0000182" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070366", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070366", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0070365" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070367", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070367", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070367", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070366" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070367", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0070365" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070368", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030858" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070368", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070368", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070366" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070368", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0070365" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0070382", "pred" : "is_a", @@ -53505,6 +118962,118 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0070831", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0005604" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070857", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010565" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070857", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031326" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070857", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050810" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070857", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070857", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070858", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070858", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031327" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070858", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070858", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904252" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070858", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070859", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010893" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070859", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031328" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070859", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070859", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904253" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070859", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070873", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032881" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070873", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0043467" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070873", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0005977" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070874", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010605" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070874", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031324" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070874", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045912" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070874", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070873" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070874", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0005977" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070875", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010604" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070875", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010907" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070875", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031325" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070875", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070873" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0070875", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0005977" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0070887", "pred" : "is_a", @@ -53565,6 +119134,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0071322", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0070887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0071331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009746" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0071331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0071333", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0001678" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0071333", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009749" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0071333", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070887" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0071375", "pred" : "is_a", @@ -53981,6 +119570,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0071971", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0070062" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072001", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048731" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072001", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001008" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0072089", "pred" : "is_a", @@ -54041,6 +119638,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0072201", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0010463" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072329", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032787" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046394" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072330", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35757" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0072359", "pred" : "is_a", @@ -54085,6 +119702,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0072537", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/CL_0000057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072560", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002071" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072560", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0003323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072560", + "pred" : "http://purl.obolibrary.org/obo/RO_0002299", + "obj" : "http://purl.obolibrary.org/obo/CL_0000169" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072575", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050673" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072575", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0072576" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072576", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022612" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072576", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0001889" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0072576", + "pred" : "http://purl.obolibrary.org/obo/RO_0002298", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0072577", "pred" : "is_a", @@ -54729,6 +120378,58 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0090317", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0006886" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090325", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0040012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090325", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050795" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090325", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0031987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090326", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0040017" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090326", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048520" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090326", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0090325" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090326", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0031987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090327", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0040013" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090327", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048521" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090327", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0090325" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090327", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0031987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090425", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0002067" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0090425", + "pred" : "http://purl.obolibrary.org/obo/RO_0002315", + "obj" : "http://purl.obolibrary.org/obo/CL_0000622" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0090435", "pred" : "is_a", @@ -54825,6 +120526,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0097049", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/CL_0000100" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097050", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904019" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097050", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/CL_0000169" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0097060", "pred" : "is_a", @@ -54893,6 +120602,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0097212", "pred" : "http://purl.obolibrary.org/obo/RO_0002592", "obj" : "http://purl.obolibrary.org/obo/GO_0005765" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097254", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003014" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097254", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007588" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097272", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097272", + "pred" : "http://purl.obolibrary.org/obo/RO_0002332", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_28938" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055082" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097275", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0097272" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097284", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904019" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0097284", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/CL_0000182" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0097355", "pred" : "is_a", @@ -55209,6 +120950,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0098751", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/CL_0001035" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0098754", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008150" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0098754", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0009636" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0098773", "pred" : "is_a", @@ -55265,6 +121014,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0098797", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0005886" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0098801", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044057" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0098801", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0003014" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0098813", "pred" : "is_a", @@ -55865,6 +121622,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0099541", "pred" : "http://purl.obolibrary.org/obo/RO_0002608", "obj" : "http://purl.obolibrary.org/obo/CHEBI_18059" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099546", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140246" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099546", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0007268" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0099547", "pred" : "is_a", @@ -55921,6 +121686,30 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0099571", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050804" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140250" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099575", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042176" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099575", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0099171" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099576", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042176" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099576", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0099170" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0099577", "pred" : "is_a", @@ -56221,6 +122010,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0110111", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0009887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032368" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032409" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110112", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0005319" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032370" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032411" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0110112" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110113", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0005319" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032369" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032410" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0110112" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110114", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0005319" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0110116", "pred" : "is_a", @@ -56385,6 +122218,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0120111", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0043005" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120158", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120158", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010710" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120158", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0030574" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120178", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006694" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120178", + "pred" : "http://purl.obolibrary.org/obo/RO_0004008", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_26764" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0120186", "pred" : "is_a", @@ -56409,6 +122262,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0120187", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0071168" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120188", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051046" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120188", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0032782" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120189", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051047" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120189", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0120188" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120189", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0032782" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051048" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0120188" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0120190", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0032782" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0120222", "pred" : "is_a", @@ -56517,6 +122402,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0140077", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0042953" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140096", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140096", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000000001" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140097", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140097", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140098", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140098", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33697" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140103", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140103", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17089" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0140112", "pred" : "is_a", @@ -56633,6 +122550,70 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0140245", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140246", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140246", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140246", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140246", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36080" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140247", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140246" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140247", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0098793" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140249", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140246" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140249", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140250", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140250", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140250", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140250", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36080" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140250" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140251", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0098793" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0140250" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140252", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0098794" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0140253", "pred" : "is_a", @@ -56641,6 +122622,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0140253", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/GO_0045026" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140318", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140318", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000000001" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0140352", "pred" : "is_a", @@ -56701,6 +122690,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0140694", "pred" : "http://purl.obolibrary.org/obo/RO_0002588", "obj" : "http://purl.obolibrary.org/obo/GO_0043228" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140734", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007588" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140734", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_28938" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140962", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048871" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140962", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048878" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0150031", "pred" : "is_a", @@ -56897,6 +122902,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0160093", "pred" : "http://purl.obolibrary.org/obo/RO_0002296", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001042" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0170055", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0005319" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0170055", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1900015", "pred" : "is_a", @@ -56929,6 +122942,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1900017", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0002534" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048583" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050794" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900076", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0032869" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048523" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048585" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1900076" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900077", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0032869" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048522" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048584" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1900076" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1900078", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0032869" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1900115", "pred" : "is_a", @@ -57189,6 +123246,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1900426", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0042742" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901142", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019538" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901142", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/PR_000009054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901143", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030163" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901143", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1901142" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901143", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/PR_000009054" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901148", "pred" : "is_a", @@ -57205,6 +123282,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901160", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_50994" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901161", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901161", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_50994" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901162", "pred" : "is_a", @@ -57565,6 +123650,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901564", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901565", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901565", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_35352" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901566", "pred" : "is_a", @@ -57617,6 +123710,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901615", "pred" : "http://purl.obolibrary.org/obo/RO_0004007", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33822" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901616", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901616", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33822" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901617", "pred" : "is_a", @@ -57629,6 +123730,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901617", "pred" : "http://purl.obolibrary.org/obo/RO_0004008", "obj" : "http://purl.obolibrary.org/obo/CHEBI_33822" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901618", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901618", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_33822" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901623", "pred" : "is_a", @@ -57673,6 +123782,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1901653", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_1901652" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901654", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901654", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_17087" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901655", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1901655", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1901654" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1901692", "pred" : "is_a", @@ -58189,6 +124314,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1902340", "pred" : "http://purl.obolibrary.org/obo/RO_0002212", "obj" : "http://purl.obolibrary.org/obo/GO_0030261" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902369", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902369", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006401" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1902414", "pred" : "is_a", @@ -58225,6 +124358,74 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1902474", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0035418" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902488", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904019" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902488", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902489", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006915" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902489", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/CL_0005026" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902494", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902494", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0003824" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902495", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0098796" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902495", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1990351" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902495", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902510", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903624" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902510", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006309" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902511", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1902510" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902511", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903625" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902511", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006309" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902512", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1902510" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902512", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903626" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1902512", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006309" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1902513", "pred" : "is_a", @@ -58969,6 +125170,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903380", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0007076" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903412", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_3098" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0070887" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903412" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903429", "pred" : "is_a", @@ -59009,6 +125226,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903441", "pred" : "http://purl.obolibrary.org/obo/RO_0002339", "obj" : "http://purl.obolibrary.org/obo/GO_0060170" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903510", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903510", + "pred" : "http://purl.obolibrary.org/obo/RO_0004007", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_37395" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903522", "pred" : "is_a", @@ -59245,6 +125470,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903569", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_1903441" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903624", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009894" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903624", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0006308" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903625", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009895" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903625", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903624" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903625", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0006308" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903626", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009896" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903626", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903624" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903626", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0006308" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903697", "pred" : "is_a", @@ -59389,6 +125646,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903781", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0061337" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903825", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0015849" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903825", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055085" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903828", "pred" : "is_a", @@ -59517,6 +125782,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1903942", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0007585" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903943", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904035" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903943", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0097284" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903944", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903943" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903944", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904036" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903944", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0097284" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1903943" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904037" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1903945", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0097284" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1903950", "pred" : "is_a", @@ -59689,6 +125986,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904037", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_1904019" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904054", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050678" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904054", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1990705" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904055", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050680" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904055", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904055", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1990705" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904056", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050679" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904056", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904054" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904056", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1990705" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904057", "pred" : "is_a", @@ -59865,6 +126194,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904179", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0060612" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904192", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904035" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904192", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1902488" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904036" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904192" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904193", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1902488" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904194", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904037" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904194", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904192" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904194", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1902488" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904204", "pred" : "is_a", @@ -59917,6 +126278,62 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904238", "pred" : "http://purl.obolibrary.org/obo/RO_0002315", "obj" : "http://purl.obolibrary.org/obo/CL_0000669" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0019218" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904251", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062012" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904251", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0008206" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031324" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062014" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904252", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904252", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0008206" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0031325" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045940" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0062013" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904251" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904253", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0008206" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904269", "pred" : "is_a", @@ -59925,6 +126342,70 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904269", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0031252" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904304", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006940" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904304", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0014831" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904305", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045986" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904305", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904304" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904305", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0014831" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904306", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904306", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904304" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904306", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0014831" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904341", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904304" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904341", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1990765" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904305" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904341" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904342", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1990765" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904343", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904306" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904343", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904341" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904343", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1990765" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904344", "pred" : "is_a", @@ -59957,6 +126438,70 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904346", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_1990768" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904304" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904347", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1990770" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904348", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904305" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904348", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904347" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904348", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1990770" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904349", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904306" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904349", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904347" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904349", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1990770" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904350", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042176" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904350", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0007039" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904351", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0042177" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904351", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904350" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904351", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0007039" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904352", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0045732" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904352", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904350" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904352", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0007039" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904375", "pred" : "is_a", @@ -60125,6 +126670,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904457", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0019228" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904484", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048732" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904484", + "pred" : "http://purl.obolibrary.org/obo/RO_0002296", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012478" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904491", "pred" : "is_a", @@ -60229,6 +126782,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904655", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0048286" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904659", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055085" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904659", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_4167" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904675", "pred" : "is_a", @@ -60261,6 +126822,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904677", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0048103" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904680", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0022857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904680", + "pred" : "http://purl.obolibrary.org/obo/RO_0004009", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_60466" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904691", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050680" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904691", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061469" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904691", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0044342" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904692", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050679" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904692", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0061469" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904692", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0044342" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904693", "pred" : "is_a", @@ -60277,6 +126870,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904693", "pred" : "http://purl.obolibrary.org/obo/RO_0002298", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001891" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904697", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050678" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904697", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1990863" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904698", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050680" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904698", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904697" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904698", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1990863" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050679" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904699", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904697" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1904699", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1990863" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1904705", "pred" : "is_a", @@ -60685,6 +127310,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1904989", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0042118" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905039", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0046942" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905039", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0055085" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1905063", "pred" : "is_a", @@ -60805,6 +127438,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1905142", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_1905139" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905146", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0007039" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905146", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/GO_0005764" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1905147", "pred" : "is_a", @@ -60881,6 +127522,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1905155", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0010324" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905165", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904350" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905165", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_1905146" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905166", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904351" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905166", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1905165" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905166", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_1905146" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905167", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904352" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905167", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1905165" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905167", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_1905146" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1905207", "pred" : "is_a", @@ -61061,6 +127734,54 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1905294", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0014033" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905298", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905298", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060284" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905298", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0060576" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905299", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010721" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905299", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905299", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905299", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1905298" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905299", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0060576" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905300", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010720" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905300", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905300", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1905298" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1905300", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0060576" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1905304", "pred" : "is_a", @@ -62345,6 +129066,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1990280", "pred" : "http://purl.obolibrary.org/obo/RO_0002339", "obj" : "http://purl.obolibrary.org/obo/GO_0000785" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990351", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0032991" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990351", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0005215" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1990502", "pred" : "is_a", @@ -62353,6 +129082,46 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1990502", "pred" : "http://purl.obolibrary.org/obo/RO_0002299", "obj" : "http://purl.obolibrary.org/obo/GO_0031045" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990705", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050673" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990705", + "pred" : "http://purl.obolibrary.org/obo/RO_0012003", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990748", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990748", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0098754" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990748", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0097237" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990748", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/CL_0000000" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990765", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990765", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0014827" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990765", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990765", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1990768", "pred" : "is_a", @@ -62361,6 +129130,22 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1990768", "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004786" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990770", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0006939" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990770", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0014827" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990770", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000066", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990770", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1990778", "pred" : "is_a", @@ -62377,6 +129162,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_1990849", "pred" : "http://purl.obolibrary.org/obo/RO_0004009", "obj" : "http://purl.obolibrary.org/obo/GO_0005773" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990863", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0050673" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990863", + "pred" : "http://purl.obolibrary.org/obo/RO_0012003", + "obj" : "http://purl.obolibrary.org/obo/CL_0000622" }, { "sub" : "http://purl.obolibrary.org/obo/GO_1990874", "pred" : "is_a", @@ -62437,6 +129230,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000068", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0002213" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000074", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060284" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000074", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0003323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010721" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000074" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000077", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0003323" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0010720" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030858" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000078", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000074" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000078", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0003323" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000106", "pred" : "is_a", @@ -62757,6 +129594,46 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000196", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0008585" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000226", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030856" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000226", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0003310" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030857" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051241" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000226" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000227", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0003310" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000228", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0030858" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000228", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051240" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000228", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000226" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000228", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0003310" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000241", "pred" : "is_a", @@ -62897,6 +129774,50 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000291", "pred" : "http://purl.obolibrary.org/obo/RO_0002211", "obj" : "http://purl.obolibrary.org/obo/GO_0051450" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044058" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044062" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000292", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0030421" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051048" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060457" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000292" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000293", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0030421" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000294", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0051047" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000294", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0060456" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000294", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000292" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000294", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0030421" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000351", "pred" : "is_a", @@ -63385,6 +130306,38 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000673", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0097049" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000674", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904035" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000674", + "pred" : "http://purl.obolibrary.org/obo/RO_0002211", + "obj" : "http://purl.obolibrary.org/obo/GO_0097050" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000675", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904036" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000675", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000675", + "pred" : "http://purl.obolibrary.org/obo/RO_0002212", + "obj" : "http://purl.obolibrary.org/obo/GO_0097050" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000676", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_1904037" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000676", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_2000674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2000676", + "pred" : "http://purl.obolibrary.org/obo/RO_0002213", + "obj" : "http://purl.obolibrary.org/obo/GO_0097050" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2000690", "pred" : "is_a", @@ -63681,6 +130634,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_2000836", "pred" : "http://purl.obolibrary.org/obo/RO_0002213", "obj" : "http://purl.obolibrary.org/obo/GO_0035935" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2001012", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0048762" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_2001012", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/GO_0072001" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2001014", "pred" : "is_a", @@ -64033,6 +130994,10 @@ "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_142796", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2605435" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1437010", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_9347" }, { "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_1437180", "pred" : "is_a", @@ -64073,6 +131038,10 @@ "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2058949", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33083" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_207598", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_9604" }, { "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2157", "pred" : "is_a", @@ -64097,6 +131066,18 @@ "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_2759", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_131567" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_314146", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_1437010" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_314293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_376913" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_314295", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_9526" }, { "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_3176", "pred" : "is_a", @@ -64185,6 +131166,10 @@ "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_35493", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33090" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_376913", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_9443" }, { "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_38254", "pred" : "is_a", @@ -64341,6 +131326,50 @@ "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_89593", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_32525" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9443", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_314146" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9526", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_314293" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9604", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_314295" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9605", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_207598" + }, { + "sub" : "http://purl.obolibrary.org/obo/NCBITaxon_9606", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_9605" + }, { + "sub" : "http://purl.obolibrary.org/obo/SO_0000001", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000110" + }, { + "sub" : "http://purl.obolibrary.org/obo/SO_0000704", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0001411" + }, { + "sub" : "http://purl.obolibrary.org/obo/SO_0000704", + "pred" : "http://purl.obolibrary.org/obo/so#member_of", + "obj" : "http://purl.obolibrary.org/obo/SO_0005855" + }, { + "sub" : "http://purl.obolibrary.org/obo/SO_0001411", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0000001" + }, { + "sub" : "http://purl.obolibrary.org/obo/SO_0005855", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/SO_0001411" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000005", "pred" : "is_a", @@ -64357,6 +131386,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000005", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0007606" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000016" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000172" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0002067" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000006", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000016" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000009", "pred" : "is_a", @@ -64417,6 +131474,86 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000015", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000466" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000471" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000949" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003923" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0030073" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0070091" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0070253" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000016", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001263" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007329" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/RO_0002216", + "obj" : "http://purl.obolibrary.org/obo/GO_0007586" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000017", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000018", "pred" : "is_a", @@ -64625,6 +131762,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000058", "pred" : "http://purl.obolibrary.org/obo/RO_0002570", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000463" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004907" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000059", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000060", "pred" : "is_a", @@ -65229,10 +132390,90 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000158", "pred" : "http://purl.obolibrary.org/obo/RO_0002007", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004111" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001245" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011272" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000159", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channel_for", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001988" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000160", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000160", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000160", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001007" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000161", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004111" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000162", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013522" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000162", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000162", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004122" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000162", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001008" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012361" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000163", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003064" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000165", "pred" : "is_a", @@ -65273,6 +132514,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000167", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000168", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000170", "pred" : "is_a", @@ -65305,6 +132558,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000171", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0007585" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000174", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000463" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000174", + "pred" : "http://purl.obolibrary.org/obo/RO_0002353", + "obj" : "http://purl.obolibrary.org/obo/GO_0007588" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000178", "pred" : "is_a", @@ -65341,6 +132602,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000179", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002514" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008907" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010428" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011164" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000209", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001697" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002217" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015212" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011138" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000126", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001092" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001676" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000304", "pred" : "is_a", @@ -65369,6 +132678,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000307", "pred" : "http://purl.obolibrary.org/obo/RO_0002491", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000317", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001207" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000317", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000320", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001204" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000320", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000325", "pred" : "is_a", @@ -65381,6 +132706,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000325", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000326", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000326", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000328", "pred" : "is_a", @@ -65401,6 +132734,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000332", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/CL_0000136" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000333", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000333", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000344", "pred" : "is_a", @@ -65561,6 +132902,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000390", "pred" : "http://purl.obolibrary.org/obo/RO_0002219", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000389" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000397", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001278" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000397", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000409", "pred" : "is_a", @@ -65589,6 +132938,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000410", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002365" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000319" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0070254" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "pred" : "http://purl.obolibrary.org/obo/RO_0003000", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000912" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000415", "pred" : "is_a", @@ -65597,6 +132962,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000415", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000440", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000440", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002384" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000440", + "pred" : "http://purl.obolibrary.org/obo/RO_0000086", + "obj" : "http://purl.obolibrary.org/obo/PATO_0001873" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000456", "pred" : "is_a", @@ -65657,6 +133034,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000468", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010000" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000471", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000471", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003103" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000474", "pred" : "is_a", @@ -65773,6 +133158,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000490", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006314" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_37395" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "pred" : "http://purl.obolibrary.org/obo/RO_0000086", + "obj" : "http://purl.obolibrary.org/obo/PATO_0000998" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000912", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000344" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000915", "pred" : "is_a", @@ -65869,6 +133274,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0000930", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0016566" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007026" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "http://purl.obolibrary.org/obo/RO_0001025", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012469" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0000931", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0000945", "pred" : "is_a", @@ -66365,6 +133794,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001007", "pred" : "http://purl.obolibrary.org/obo/RO_0002492", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000066" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8450002" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0097254" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "pred" : "http://purl.obolibrary.org/obo/RO_0002492", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000066" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001009", "pred" : "is_a", @@ -66549,6 +133994,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001043", "pred" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001045", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001045", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001046", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001046", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001046", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001048", "pred" : "is_a", @@ -66577,6 +134042,58 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001049", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005068" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012361" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001052", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000025" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007329" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channel_for", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001970" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001064", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_into", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004913" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001068", "pred" : "is_a", @@ -66625,6 +134142,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001072", "pred" : "http://purl.obolibrary.org/obo/RO_0002179", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000154" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410024" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001074", "pred" : "is_a", @@ -66737,6 +134270,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001090", "pred" : "http://purl.obolibrary.org/obo/RO_0003001", "obj" : "http://purl.obolibrary.org/obo/CL_0000214" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001092", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001092", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000096", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001093" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001093", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001093", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#anteriorly_connected_to", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001092" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001095", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001095", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004247" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001095", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018142" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001096", "pred" : "is_a", @@ -66765,6 +134326,46 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001103", "pred" : "http://purl.obolibrary.org/obo/RO_0002495", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010084" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001113", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001113", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001115", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011138" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#protects", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002240" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001133", "pred" : "is_a", @@ -66837,6 +134438,46 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001137", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005617" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005806" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001639" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005487" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006877" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "pred" : "http://purl.obolibrary.org/obo/RO_0002376", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001145", "pred" : "is_a", @@ -66853,6 +134494,102 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001145", "pred" : "http://purl.obolibrary.org/obo/RO_0002179", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000992" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005604" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_into", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001155", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001155", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001155", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001155", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001161", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009870" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009870" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000502" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000508" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001165", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009870" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008858" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008861" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001167", "pred" : "is_a", @@ -66865,6 +134602,170 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001167", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001168", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001168", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001169", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001169", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001170", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001206" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001170", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001170", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007826" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001171", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011858" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001171" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001172", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002294" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001246" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001282" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001174", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001174", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001174", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001174", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_into", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005604" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001176" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "http://purl.obolibrary.org/obo/RO_0002495", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010081" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001175", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_into", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001176", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001176", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005171" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001176", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001177", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001177", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005171" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001177", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001178", "pred" : "is_a", @@ -66909,6 +134810,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001190", "pred" : "http://purl.obolibrary.org/obo/RO_0002178", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000992" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001193", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001194", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001194", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001194", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001640" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001199", "pred" : "is_a", @@ -66949,6 +134870,262 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001201", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001167" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008858" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001204", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001204", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001204", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001205", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009566" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001205", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001206", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001243" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001206", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001206", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001243" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001207", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001207", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001207", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001208", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009566" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001208", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001209", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001243" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001209", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001209", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001243" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011148" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "pred" : "http://purl.obolibrary.org/obo/RO_0001025", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003332" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_40674" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001213", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004923" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001213", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001213", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001981" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001213", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012425" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001215", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005617" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001215", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001215", + "pred" : "http://purl.obolibrary.org/obo/RO_0002376", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003713" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001238", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004780" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001238", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001204" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001242", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004786" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001242", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001243", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004782" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001243", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000931" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003704" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001279" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004058" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014719" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001246", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001279" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001262", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000328" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001262", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013232" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007324" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/CL_0002064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000016" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003923" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001264", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001265", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001265", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001265", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1000024" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001268", "pred" : "is_a", @@ -66989,6 +135166,158 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001276", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001199" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000485" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003350" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004808" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001278", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001278", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001207" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001172" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003704" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001279", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001171" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008835" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003909" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006877" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006841" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "http://purl.obolibrary.org/obo/RO_0002226", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003704" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014716" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001172" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000182" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001282", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001353", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001353", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001353", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000931" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001366", "pred" : "is_a", @@ -67397,6 +135726,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001606", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001606" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004234" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007521" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002346" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "http://purl.obolibrary.org/obo/RO_0002372", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "http://purl.obolibrary.org/obo/RO_0002373", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "pred" : "http://purl.obolibrary.org/obo/RO_0002568", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001608" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004234" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002346" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "pred" : "http://purl.obolibrary.org/obo/RO_0002372", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "pred" : "http://purl.obolibrary.org/obo/RO_0002373", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001608", + "pred" : "http://purl.obolibrary.org/obo/RO_0002568", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001607" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001612", "pred" : "is_a", @@ -67441,6 +135818,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001638", "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_from", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001982" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001639", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001639", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010194" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001639", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001639", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channels_into", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012254" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001640", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001645", "pred" : "is_a", @@ -67557,6 +135970,94 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001676", "pred" : "http://purl.obolibrary.org/obo/RO_0002221", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003687" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002513" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003462" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015060" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008895" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002513" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003462" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011164" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002517" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006227" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001679", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011156" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015212" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004088" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011156" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000126", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011156" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001697", + "pred" : "http://purl.obolibrary.org/obo/RO_0001015", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000019" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001703", "pred" : "is_a", @@ -67609,6 +136110,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001708", "pred" : "http://purl.obolibrary.org/obo/RO_0002576", "obj" : "http://purl.obolibrary.org/obo/UBERON_0011595" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000475" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010314" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004089" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011595" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "pred" : "http://purl.obolibrary.org/obo/RO_0002551", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003277" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001710", "pred" : "is_a", @@ -68105,6 +136626,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001833", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001834", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001833" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001834", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001709" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001834", + "pred" : "http://purl.obolibrary.org/obo/RO_0002495", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011592" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001835", "pred" : "is_a", @@ -68213,6 +136746,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001901", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001902", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001902", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001204" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001902", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000164" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001915", "pred" : "is_a", @@ -68365,6 +136910,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001969", "pred" : "http://purl.obolibrary.org/obo/RO_0002221", "obj" : "http://purl.obolibrary.org/obo/CL_0000232" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006314" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_16990" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_22868" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CHEBI_36277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/RO_0000086", + "obj" : "http://purl.obolibrary.org/obo/PATO_0001735" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/RO_0002216", + "obj" : "http://purl.obolibrary.org/obo/GO_0007586" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001971", "pred" : "is_a", @@ -68413,6 +136990,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001976", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001978", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001978", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001979", "pred" : "is_a", @@ -68541,6 +137126,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0001986", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/CL_0000115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001988", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0001988", + "pred" : "http://purl.obolibrary.org/obo/RO_0002353", + "obj" : "http://purl.obolibrary.org/obo/GO_0030421" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0001994", "pred" : "is_a", @@ -68605,6 +137198,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002016", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002017", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002017", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005806" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002020", "pred" : "is_a", @@ -68633,6 +137234,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002028", "pred" : "http://purl.obolibrary.org/obo/RO_0002495", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000485" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034932" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002031", "pred" : "is_a", @@ -69069,6 +137690,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002094", "pred" : "http://purl.obolibrary.org/obo/RO_0002220", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002084" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002095", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002095", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002097", "pred" : "is_a", @@ -69133,6 +137762,138 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002105", "pred" : "http://purl.obolibrary.org/obo/RO_0002216", "obj" : "http://purl.obolibrary.org/obo/GO_0007605" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005057" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0017672" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7776" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002106", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006293" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002365" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005172" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006925" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002405" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008836" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/RO_0003000", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001970" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#site_of", + "obj" : "http://purl.obolibrary.org/obo/GO_0002384" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#site_of", + "obj" : "http://purl.obolibrary.org/obo/GO_0005978" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002107", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#site_of", + "obj" : "http://purl.obolibrary.org/obo/GO_0005980" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002108", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0017672" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018707" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002294" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006242" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002110", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002111", "pred" : "is_a", @@ -69157,6 +137918,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002112", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0001106", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002114", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002118", "pred" : "is_a", @@ -69601,6 +138382,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002275", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002298" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011216" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0015721" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002296", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002296", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009664" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002296", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002298", "pred" : "is_a", @@ -69893,6 +138706,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002346", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/CL_0000133" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003827" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004247" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015008" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013507" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002348", "pred" : "is_a", @@ -70245,6 +139078,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002390", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000025" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003928" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008835" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#channel_for", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001970" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008001" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011597" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012071" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011085" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002396", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011156" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002400", "pred" : "is_a", @@ -70417,6 +139298,58 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002410", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001016" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002513" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008001" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011094" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003458" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004247" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004451" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015007" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013505" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002415", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011676" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002415", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000154" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002415", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002416", "pred" : "is_a", @@ -70481,6 +139414,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002419", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002097" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011216" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001007" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002294" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/RO_0002215", + "obj" : "http://purl.obolibrary.org/obo/GO_0061007" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002423", + "pred" : "http://purl.obolibrary.org/obo/RO_0002492", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000066" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002424", "pred" : "is_a", @@ -70545,6 +139506,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002458", "pred" : "http://purl.obolibrary.org/obo/RO_0002178", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002240" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002466", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002466", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002469", "pred" : "is_a", @@ -70585,6 +139554,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002506", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001769" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002511", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002511", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002511", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002082" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002511", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001133" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002513", "pred" : "is_a", @@ -70617,6 +139602,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002514", "pred" : "http://purl.obolibrary.org/obo/RO_0002353", "obj" : "http://purl.obolibrary.org/obo/GO_0001957" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002517", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002517", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002517", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002517", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003128" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002521", "pred" : "is_a", @@ -70685,6 +139686,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002532", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/CL_0000352" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002533", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002533", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002536", "pred" : "is_a", @@ -70745,6 +139754,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0002553", "pred" : "http://purl.obolibrary.org/obo/RO_0001015", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000463" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002558", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002553" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002561", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002558" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002561", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0002561", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001017" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0002616", "pred" : "is_a", @@ -71237,6 +140262,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003084", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007005" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003524" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_2001073" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005805" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003089", "pred" : "is_a", @@ -71305,6 +140346,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003104", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/CL_0008019" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003112", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003112", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002241" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003113", "pred" : "is_a", @@ -71441,6 +140494,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003218", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000992" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003235", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0035037" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003235", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001709" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003236", "pred" : "is_a", @@ -71477,6 +140538,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003258", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0015833" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003259", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003259", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003352" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003259", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003260", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003260", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003260", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003269", "pred" : "is_a", @@ -71489,6 +140574,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003269", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000019" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001708" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001709" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "pred" : "http://purl.obolibrary.org/obo/RO_0002576", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001709" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003278", "pred" : "is_a", @@ -71525,6 +140630,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003279", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001986" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003281", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003281", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003282", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003282", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000948" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003283", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001975" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003283", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003284", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003284", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003294", "pred" : "is_a", @@ -71609,6 +140750,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003316", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001040" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034995" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001709" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009526" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003324", "pred" : "is_a", @@ -71621,6 +140778,66 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003324", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006905" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001208" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003329", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003330", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001208" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003330", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003331", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001208" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003331", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003332", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001205" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003332", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003334", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001209" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003334", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003335", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001209" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003335", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003336", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001206" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003336", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003338", "pred" : "is_a", @@ -71641,6 +140858,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003339", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001207" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003342", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003343", "pred" : "is_a", @@ -71649,6 +140878,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003343", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003346", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001207" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003346", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003350", "pred" : "is_a", @@ -71677,6 +140914,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003351", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007690" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003352", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003352", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003353", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003353", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003354", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001278" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003354", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0016885" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003354", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003364", "pred" : "is_a", @@ -71825,6 +141090,50 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003390", "pred" : "http://purl.obolibrary.org/obo/RO_0001025", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002402" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003393", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003393", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001008" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003394", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003394", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003395", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003334" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003395", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003335" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003396", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007826" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003397", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001170" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003397", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003336" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003406", "pred" : "is_a", @@ -71905,6 +141214,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003443", "pred" : "http://purl.obolibrary.org/obo/RO_0001025", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002224" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003452", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018649" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003452", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003457", "pred" : "is_a", @@ -71949,6 +141266,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003469", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003643" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003496" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009657" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001834" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001612" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003471", "pred" : "is_a", @@ -71981,6 +141314,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003476", "pred" : "http://purl.obolibrary.org/obo/RO_0002179", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001004" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003477", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013136" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003477", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001834" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003478", "pred" : "is_a", @@ -71997,6 +141338,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003479", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003519" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003524" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003489", "pred" : "is_a", @@ -72181,6 +141530,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003519", "pred" : "http://purl.obolibrary.org/obo/RO_0001025", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002224" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003524", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001981" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003524", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003526", "pred" : "is_a", @@ -72197,6 +141554,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003528", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000955" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003534", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000014" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003534", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003536", "pred" : "is_a", @@ -72361,6 +141726,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003593", "pred" : "http://purl.obolibrary.org/obo/RO_0001025", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002224" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003599", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002384" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003599", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003601", "pred" : "is_a", @@ -72533,6 +141906,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003643", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003509" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003665", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004518" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003665", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003665", + "pred" : "http://purl.obolibrary.org/obo/RO_0002371", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001095" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003684", "pred" : "is_a", @@ -72557,6 +141942,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003687", "pred" : "http://purl.obolibrary.org/obo/RO_0002570", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001896" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000982" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011138" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001092" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001093" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003697", "pred" : "is_a", @@ -72565,6 +141966,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003697", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000916" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003703", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003704", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003704", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003704", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003711", "pred" : "is_a", @@ -72577,6 +141994,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003711", "pred" : "http://purl.obolibrary.org/obo/RO_0002170", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001585" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003713", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003713", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001639" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003714", "pred" : "is_a", @@ -72881,6 +142306,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003891", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002384" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000485" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009550" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003898", "pred" : "is_a", @@ -72937,6 +142394,82 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0003920", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004582" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007026" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000925" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007499" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003922", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003923", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003923", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010375" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003923", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003924", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003924", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010376" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0003924", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008835" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0003928", "pred" : "is_a", @@ -73097,6 +142630,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004022", "pred" : "http://purl.obolibrary.org/obo/RO_0002220", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003842" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000025" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004058", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004060", "pred" : "is_a", @@ -73197,6 +142750,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004064", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004066", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009292" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004066", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0005001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004068", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009292" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004068", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004066" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004068", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000126", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008816" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004068", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004066" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004087", "pred" : "is_a", @@ -73213,6 +142790,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004088", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004089", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001444" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004089", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004089", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004089", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001456" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004111", "pred" : "is_a", @@ -73257,6 +142850,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004121", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000467" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000990" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001008" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "pred" : "http://purl.obolibrary.org/obo/RO_0002492", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000066" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004123", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005983" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004123", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002349" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004123", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#layer_part_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002349" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004124", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004123" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004124", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004124", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/GO_0036194" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004126", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004124" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004126", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001083" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004128", "pred" : "is_a", @@ -73489,6 +143130,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004215", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001137" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004220", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004221" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004220", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004220", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011198" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004226" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012367" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004222", "pred" : "is_a", @@ -73513,6 +143182,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004226", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004231", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004231", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004233", "pred" : "is_a", @@ -73553,6 +143230,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004237", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001981" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004238", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004238", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004239", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004221" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004239", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004239", + "pred" : "http://purl.obolibrary.org/obo/RO_0002131", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011201" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004240", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004240", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004240", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004242", "pred" : "is_a", @@ -73909,6 +143618,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004375", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0011582" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004451", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004451", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000096", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001095" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004455", "pred" : "is_a", @@ -73969,6 +143686,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004465", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000974" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004468", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001015" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004468", + "pred" : "http://purl.obolibrary.org/obo/RO_0002371", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004469", "pred" : "is_a", @@ -74077,6 +143802,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004517", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/CL_4033017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004518", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014892" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004518", + "pred" : "http://purl.obolibrary.org/obo/RO_0002371", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004521", "pred" : "is_a", @@ -74093,6 +143826,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004522", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002204" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004525", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003381" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004525", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003452" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004525", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006570" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004526", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003382" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004526", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003452" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004526", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006571" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004535", "pred" : "is_a", @@ -74181,6 +143938,10 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004582", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004590", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001630" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004638", "pred" : "is_a", @@ -74189,6 +143950,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004638", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001981" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000182" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004647", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004663", "pred" : "is_a", @@ -74501,6 +144282,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004756", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002067" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004760", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004760", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004760", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004761", "pred" : "is_a", @@ -74609,6 +144402,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004780", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004786" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004781", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000030" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004781", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004781", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005033" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004782", "pred" : "is_a", @@ -74617,6 +144422,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004782", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004783", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004783", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004783", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004784", "pred" : "is_a", @@ -74661,6 +144478,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004786", "pred" : "http://purl.obolibrary.org/obo/RO_0002220", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006909" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004790", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000414" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004790", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007771" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004790", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0019319" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004792", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004795" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004792", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000016" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004793", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004795" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004793", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004794", "pred" : "is_a", @@ -74669,6 +144514,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004794", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004795", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004795", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004797", "pred" : "is_a", @@ -74725,6 +144578,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004815", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001558" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034932" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034969" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_1000488" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004821", "pred" : "is_a", @@ -74749,6 +144622,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004821", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002299" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004822", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004820" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004822", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004823", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004820" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004823", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003704" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004830", "pred" : "is_a", @@ -74765,6 +144654,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004831", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003832" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004832", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001134" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004832", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004833", "pred" : "is_a", @@ -74773,6 +144670,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004833", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001833" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004834", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004834", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004834", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005171" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004848", "pred" : "is_a", @@ -74817,6 +144726,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004852", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004535" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004854", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004854", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004782" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004857", "pred" : "is_a", @@ -74861,6 +144778,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004864", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000966" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004867", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002553" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004867", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001697" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004872", "pred" : "is_a", @@ -74993,6 +144918,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004906", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004907", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004907", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004907", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004908", "pred" : "is_a", @@ -75021,6 +144958,74 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004911", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000992" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007499" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004912", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004913", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004913", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004913", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004914" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004914", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034944" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004914", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000320" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004915", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004915", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004915", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004916", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004916", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004916", + "pred" : "http://purl.obolibrary.org/obo/RO_0002216", + "obj" : "http://purl.obolibrary.org/obo/GO_0030421" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004921", "pred" : "is_a", @@ -75057,6 +145062,90 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004924", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004926", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004938" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004926", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004932", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003331" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004932", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004934", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001200" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004934", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004936", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004937" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004936", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004937", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001200" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004937", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004938", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000009" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004938", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004938", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004939", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004938" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004939", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004940", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004938" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004940", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004941", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004938" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004941", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001176" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004942", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004938" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004942", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001177" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0004952", "pred" : "is_a", @@ -75069,6 +145158,102 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0004952", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002186" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004988", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004999" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004988", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004993", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000317" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004993", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004995", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001199" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004995", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004997", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004998" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004997", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004997", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004998" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004998", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001199" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004998", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004999", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000344" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004999", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0004999", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005000", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004999" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005000", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005001", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004999" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005001", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005002", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004999" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005002", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001176" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005003", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004999" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005003", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005031", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0036294" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005031", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001834" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005032", "pred" : "is_a", @@ -75077,6 +145262,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005032", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001835" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005033", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000344" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005033", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005033", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005039", "pred" : "is_a", @@ -75165,6 +145362,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005062", "pred" : "http://purl.obolibrary.org/obo/BSPO_0000126", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005064", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005064", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003382" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005066", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005066", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003381" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005068", "pred" : "is_a", @@ -75273,6 +145486,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005169", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005172", "pred" : "is_a", @@ -75333,6 +145558,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005194", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003834" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005203", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005203", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005221", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005221", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001280" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005222", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005233", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005233", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014702" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005233", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004068" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005234", "pred" : "is_a", @@ -75665,6 +145926,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005434", "pred" : "http://purl.obolibrary.org/obo/RO_0002160", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_8287" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005436", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004573" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005436", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001640" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013685" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001677" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "pred" : "http://purl.obolibrary.org/obo/RO_0002570", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000377" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005460", "pred" : "is_a", @@ -75821,6 +146106,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005598", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002100" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005602", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003281" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005602", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002296" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005602", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003281" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005604", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005604", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005604", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005171" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005613", "pred" : "is_a", @@ -75845,6 +146154,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005614", "pred" : "http://purl.obolibrary.org/obo/RO_0002220", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001804" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005616", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012254" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005616", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005617", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005617", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005622", "pred" : "is_a", @@ -75865,6 +146190,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005631", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0016887" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005637", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001276" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005637", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005638", "pred" : "is_a", @@ -75929,6 +146262,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005673", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003365" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005685", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002296" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005685", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005688", "pred" : "is_a", @@ -75961,6 +146302,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005702", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004348" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003397" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011642" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003284" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003397" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011642" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005720", "pred" : "is_a", @@ -76145,10 +146518,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005805", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005806", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005844", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001948" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005845", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005844" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005845", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006071" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005856", "pred" : "is_a", @@ -76217,6 +146602,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005867", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007237" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005868", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005868", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007238" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005902", "pred" : "is_a", @@ -76261,6 +146654,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005944", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001434" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003932" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005945", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003112" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005946", "pred" : "is_a", @@ -76361,6 +146766,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0005985", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000948" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002302" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004124" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002302" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0005989", "pred" : "is_a", @@ -76417,6 +146842,94 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006056", "pred" : "http://purl.obolibrary.org/obo/BSPO_0000122", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006068", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001474" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006068", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006071", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011676" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006071", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000154" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006071", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000099", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001245" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006071", + "pred" : "http://purl.obolibrary.org/obo/RO_0002551", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006076" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002090" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012477" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005434" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008231" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014477" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000915" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002090" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006071" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006071" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001137" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006207", "pred" : "is_a", @@ -76473,6 +146986,50 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006218", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002081" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002517" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001679" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1100000" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006236", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006236", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000209" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006238", "pred" : "is_a", @@ -76525,6 +147082,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006241", "pred" : "http://purl.obolibrary.org/obo/RO_0002387", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002240" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006264", "pred" : "is_a", @@ -76573,6 +147150,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006268", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006271", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006271", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013685" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006271", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001697" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006279", "pred" : "is_a", @@ -76613,6 +147202,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006283", "pred" : "http://purl.obolibrary.org/obo/RO_0002387", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002082" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005602" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006293", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004872" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006304", "pred" : "is_a", @@ -76757,6 +147374,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006538", "pred" : "http://purl.obolibrary.org/obo/RO_0003001", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001004" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006555", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000025" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006555", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001008" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006562", "pred" : "is_a", @@ -76797,6 +147422,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006567", "pred" : "http://purl.obolibrary.org/obo/RO_0002150", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006563" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006570", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006570", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002080" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006571", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006571", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002084" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410024" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000931" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006595", "pred" : "is_a", @@ -76861,6 +147522,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006603", "pred" : "http://purl.obolibrary.org/obo/RO_0002387", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000926" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006660", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018260" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006660", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006660", + "pred" : "http://purl.obolibrary.org/obo/RO_0002220", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000009" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006670", "pred" : "is_a", @@ -76893,6 +147566,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006677", "pred" : "http://purl.obolibrary.org/obo/RO_0002007", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006686", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006686", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006761", "pred" : "is_a", @@ -76937,6 +147618,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006815", "pred" : "http://purl.obolibrary.org/obo/uberon/core#protects", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006828", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002511" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006828", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002081" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006833", "pred" : "is_a", @@ -76969,6 +147658,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006834", "pred" : "http://purl.obolibrary.org/obo/uberon/core#site_of", "obj" : "http://purl.obolibrary.org/obo/GO_0009790" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006841", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006841", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006841", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004647" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006846", "pred" : "is_a", @@ -76977,6 +147678,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006846", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0002255" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006866", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006866", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001245" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006866", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006876", "pred" : "is_a", @@ -76985,6 +147698,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0006876", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000062" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006877", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002201" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006877", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006876" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0006877", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0006904", "pred" : "is_a", @@ -77265,6 +147990,70 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007135", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007144", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007144", + "pred" : "http://purl.obolibrary.org/obo/RO_0002494", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002533" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007147", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007147", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007147", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007148", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007148", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007148", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007158", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007158", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007158", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007159", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007159", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007159", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007177", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011189" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007177", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000317" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007188", "pred" : "is_a", @@ -77357,6 +148146,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007237", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004362" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007238", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007238", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004362" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007239", "pred" : "is_a", @@ -77613,6 +148410,58 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007304", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000026" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001263" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007324", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014719" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003928" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007375", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007375", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000033" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007376", "pred" : "is_a", @@ -77721,6 +148570,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007503", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007521", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007521", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000192" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007521", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007522", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007522", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/CL_0000737" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007522", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002036" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007524", "pred" : "is_a", @@ -77809,6 +148682,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007651", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007652", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003832" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007652", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007688", "pred" : "is_a", @@ -77913,6 +148794,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007811", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006562" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002415" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006071" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "pred" : "http://purl.obolibrary.org/obo/RO_0002160", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "pred" : "http://purl.obolibrary.org/obo/RO_0002216", + "obj" : "http://purl.obolibrary.org/obo/GO_0007626" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "pred" : "http://purl.obolibrary.org/obo/RO_0002494", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007144" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007823", "pred" : "is_a", @@ -77929,6 +148830,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007823", "pred" : "http://purl.obolibrary.org/obo/RO_0002551", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010719" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007826", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007826", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002358" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0007826", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001178" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0007828", "pred" : "is_a", @@ -78021,6 +148934,10 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0007914", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007811" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008001", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001474" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008114", "pred" : "is_a", @@ -78045,6 +148962,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0008115", "pred" : "http://purl.obolibrary.org/obo/RO_0002007", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007844" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001474" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008193", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010528" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008196", "pred" : "is_a", @@ -78101,6 +149026,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0008339", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_8410081" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008342", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008342", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000320" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008346", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013636" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008346", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008342" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008397", "pred" : "is_a", @@ -78173,6 +149114,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0008826", "pred" : "http://purl.obolibrary.org/obo/RO_0003001", "obj" : "http://purl.obolibrary.org/obo/CL_0002063" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007499" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008835", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003894" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007499" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009854" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008836", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008835" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008851", "pred" : "is_a", @@ -78185,6 +149174,70 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0008851", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004364" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018261" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034933" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004222" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001135" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001167" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009870" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001165" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001202" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008858", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000325" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000414" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004998" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "pred" : "http://purl.obolibrary.org/obo/RO_0000086", + "obj" : "http://purl.obolibrary.org/obo/PATO_0002299" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001166" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008870", "pred" : "is_a", @@ -78333,6 +149386,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0008951", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002168" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005178" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011148" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "pred" : "http://purl.obolibrary.org/obo/RO_0001025", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001972" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0008998", "pred" : "is_a", @@ -78469,6 +149542,62 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009145", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014387" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015060" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003932" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005863" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014387" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015060" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009191" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009196", "pred" : "is_a", @@ -78477,6 +149606,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009196", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000922" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009204", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009501" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009204", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004068" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012314" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009479", "pred" : "is_a", @@ -78493,6 +149634,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009480", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006211" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009482", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009482", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006235" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009483", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009483", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006235" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009494", "pred" : "is_a", @@ -78513,6 +149670,50 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009494", "pred" : "http://purl.obolibrary.org/obo/RO_0002254", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003099" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006235" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009550" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009501", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009501", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004066" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009501", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009503", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009503", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001046" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009505", "pred" : "is_a", @@ -78529,6 +149730,82 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009505", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002539" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009521", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009521", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009521", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009526", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009526", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009526", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005868" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009548", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001281" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009548", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009548", + "pred" : "http://purl.obolibrary.org/obo/RO_0002226", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009549", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001281" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009549", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009549", + "pred" : "http://purl.obolibrary.org/obo/RO_0002226", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009550", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000925" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009550", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006235" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009566", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018257" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009566", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002100" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009568", + "pred" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002100" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009569", "pred" : "is_a", @@ -78693,6 +149970,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009618", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005256" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009621", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002329" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009621", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002415" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009644", "pred" : "is_a", @@ -78749,6 +150034,98 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009662", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002028" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009664", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009664", + "pred" : "http://purl.obolibrary.org/obo/RO_0001025", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001179" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012463" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000163" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "pred" : "http://purl.obolibrary.org/obo/RO_0002219", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009846" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000163" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012465" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009669" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002365" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010375" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009708", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003923" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002365" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005177" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010376" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009709", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003924" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009712", "pred" : "is_a", @@ -78817,6 +150194,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009751", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000948" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009752", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003104" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009752", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009758", "pred" : "is_a", @@ -78869,6 +150254,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009842", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0002422" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009521" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000163" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0009854", "pred" : "is_a", @@ -78997,6 +150406,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0009955", "pred" : "http://purl.obolibrary.org/obo/RO_0002385", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001785" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010371" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013697" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034969" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007329" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010000", "pred" : "is_a", @@ -79049,6 +150474,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010042", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004362" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010045", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010045", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007238" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010046", "pred" : "is_a", @@ -79081,6 +150514,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010077", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003914" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034932" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005604" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001175" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010083", "pred" : "is_a", @@ -79161,6 +150618,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010136", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010152", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010152", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004790" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010161", "pred" : "is_a", @@ -79173,6 +150638,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010161", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001981" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010162", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011676" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010162", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010162", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010183", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000440" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010183", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010183", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010188", "pred" : "is_a", @@ -79197,10 +150686,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010192", "pred" : "http://purl.obolibrary.org/obo/RO_0002178", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000991" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010194", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005806" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010194", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010194", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010199", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000466" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010204", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010204", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010227", "pred" : "is_a", @@ -79257,6 +150766,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010252", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0007098" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010259" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010258" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010256", "pred" : "is_a", @@ -79325,6 +150850,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010259", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010276", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010276", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001130" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010285", "pred" : "is_a", @@ -79509,6 +151042,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010333", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005728" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010258" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010253" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010338" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010336", "pred" : "is_a", @@ -79541,6 +151106,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010337", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010339" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010338", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010045" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010338", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010341" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010338", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010045" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010339", "pred" : "is_a", @@ -79689,6 +151266,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010371", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/CL_0002077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009708" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001048" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006598" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009709" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010377", "pred" : "is_a", @@ -79729,6 +151338,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010378", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004873" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001265" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001194" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013126" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001265" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003713" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "pred" : "http://purl.obolibrary.org/obo/RO_0002433", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010409", "pred" : "is_a", @@ -79793,6 +151438,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010523", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010527", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002558" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010527", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001474" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010528", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010527" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010528", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008193" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010707", "pred" : "is_a", @@ -79889,6 +151550,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0010912", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004288" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010913", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0010913", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003089" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0010959", "pred" : "is_a", @@ -79909,6 +151578,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011004", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002539" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008895" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011085", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004362" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007844" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011095", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011095", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002412" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011095", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005866" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011108", "pred" : "is_a", @@ -79945,6 +151662,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011138", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003089" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011148", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000414" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011148", + "pred" : "http://purl.obolibrary.org/obo/RO_0001025", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000009" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011148", + "pred" : "http://purl.obolibrary.org/obo/RO_0002150", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003350" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011156", "pred" : "is_a", @@ -79985,6 +151714,54 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011164", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011171", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002217" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003277" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011171", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003278" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011185", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011185", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011185", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005409" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011189", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004780" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011189", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001207" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011198", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012367" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011198", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011201", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012367" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011201", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001168" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011215", "pred" : "is_a", @@ -80037,6 +151814,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011234", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/UBERON_0011824" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011241", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011241", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003112" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011241", + "pred" : "http://purl.obolibrary.org/obo/RO_0002254", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005945" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011249", "pred" : "is_a", @@ -80133,6 +151922,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011585", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000061" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011592", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011592", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003235" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011592", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004068" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011592", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005868" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011595", "pred" : "is_a", @@ -80165,6 +151970,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011596", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005867" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011597", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012360" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011597", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003277" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011642", "pred" : "is_a", @@ -80201,6 +152014,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011676", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0013701" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003463" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004247" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004451" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009568" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011695", "pred" : "is_a", @@ -80221,6 +152050,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011772", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004768" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011773", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011773", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011597" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011773", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011597" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011777", "pred" : "is_a", @@ -80381,6 +152222,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011865", "pred" : "http://purl.obolibrary.org/obo/RO_0002433", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001777" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011878", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018261" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011878", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001096" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011878", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001134" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011892", "pred" : "is_a", @@ -80453,6 +152306,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0011953", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006924" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011955", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001143" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011955", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011956", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001143" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0011956", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0011997", "pred" : "is_a", @@ -80469,6 +152338,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012054", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003082" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012071", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003457" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012071", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008907" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012071", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012072", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012072", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003113" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012072", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007375" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012075", "pred" : "is_a", @@ -80589,6 +152482,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012360", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001708" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012361", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012361", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012367", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018261" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012367", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001262" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012375", "pred" : "is_a", @@ -80625,6 +152534,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012418", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003476" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012423", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012423", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/GO_0005902" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012425", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012425", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012429", "pred" : "is_a", @@ -80665,6 +152590,42 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012430", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001773" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012465" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012464", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000161" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012464", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012465", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012465", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012465", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012466", "pred" : "is_a", @@ -80681,6 +152642,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012467", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0000608" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012469", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012469", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012475", "pred" : "is_a", @@ -80697,6 +152666,106 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012475", "pred" : "http://purl.obolibrary.org/obo/RO_0002576", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010708" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012477", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005434" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012477", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001137" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012477", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000974" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012478", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012478", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012480", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000344" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012480", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012481", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012482", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018257" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012482", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012483", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012483", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012485", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012423" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012485", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012486", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018261" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012486", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012488", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011201" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012488", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012489", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011198" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012489", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012490", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012490", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011198" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012490", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0012504", "pred" : "is_a", @@ -80705,6 +152774,34 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0012504", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1100000" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012651", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001199" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012651", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001199" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0012651", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012650" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013126", "pred" : "is_a", @@ -80745,6 +152842,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0013140", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004581" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013158", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003408" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013158", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006235" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013212", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013212", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004760" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013232", "pred" : "is_a", @@ -80781,6 +152894,102 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0013479", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004702" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013501", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004590" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013501", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014783" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011094" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018142" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_2001457" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013504" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013504", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013504", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0018142" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003601" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011094" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015007" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_2001457" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013506" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002413" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013506", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013506", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015007" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011094" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015008" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_2001457" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013508" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "pred" : "http://purl.obolibrary.org/obo/RO_0002387", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002347" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011095" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013508", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015008" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013514", "pred" : "is_a", @@ -80821,6 +153030,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0013525", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013636", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001902" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013636", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013636", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001902" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013685", "pred" : "is_a", @@ -80849,6 +153070,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0013694", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000955" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013695", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000397" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013695", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001986" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013697", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0013697", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0013700", "pred" : "is_a", @@ -80977,6 +153214,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0014399", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003909" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014400", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014399" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014400", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001281" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014402", "pred" : "is_a", @@ -81057,6 +153302,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0014636", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0003038" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005291" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010371" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004066" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "pred" : "http://purl.obolibrary.org/obo/RO_0002202", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000076" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014703", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000490" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014703", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010371" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014703", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001353" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014704", "pred" : "is_a", @@ -81081,6 +153358,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0014716", "pred" : "http://purl.obolibrary.org/obo/RO_0002170", "obj" : "http://purl.obolibrary.org/obo/UBERON_0009911" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014717", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011858" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014717", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000414" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014717", + "pred" : "http://purl.obolibrary.org/obo/RO_0002473", + "obj" : "http://purl.obolibrary.org/obo/CL_0000319" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014719", "pred" : "is_a", @@ -81117,6 +153406,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0014777", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0006241" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014783", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001630" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014783", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013765" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0014783", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000162" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0014793", "pred" : "is_a", @@ -81181,6 +153482,46 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0014907", "pred" : "http://purl.obolibrary.org/obo/RO_0002202", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005805" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015007", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015007", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015007", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005181" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006073" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015060", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015060", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010363" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015060", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011156" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015128", "pred" : "is_a", @@ -81289,6 +153630,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0015228", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0001690" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015280", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007324" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015280", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015212" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015280", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000120", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007324" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015281", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015212" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015281", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0000121", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000017" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015329", "pred" : "is_a", @@ -81305,6 +153670,70 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0015410", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004535" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015480", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015480", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005436" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001115" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015480" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001193" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "pred" : "http://purl.obolibrary.org/obo/RO_0002170", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015480" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015485", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1100000" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015485", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015485", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015716", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001278" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015716", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014703" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015716", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015757", "pred" : "is_a", @@ -81317,6 +153746,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0015783", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015796", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015796", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015796", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0015808", "pred" : "is_a", @@ -81337,6 +153778,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0015833", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015834", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001238" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0015834", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0008342" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016405", "pred" : "is_a", @@ -81357,6 +153806,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0016458", "pred" : "http://purl.obolibrary.org/obo/RO_0002570", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001043" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016478", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016478", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016478", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016490", "pred" : "is_a", @@ -81377,6 +153838,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0016509", "pred" : "http://purl.obolibrary.org/obo/RO_0002572", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002080" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016512", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016512", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002114" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016513", "pred" : "is_a", @@ -81433,6 +153902,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0016550", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002240" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016552", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016552", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000065" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016553", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000912" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016553", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004785" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016566", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0036215" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016570", "pred" : "is_a", @@ -81445,6 +153934,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0016570", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002315" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000481" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003072" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003072" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016879", "pred" : "is_a", @@ -81473,6 +153978,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0016880", "pred" : "http://purl.obolibrary.org/obo/RO_0002496", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000111" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016885", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016885", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016886", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002385" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0016886", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006866" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0016887", "pred" : "is_a", @@ -81509,6 +154030,30 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0017672", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005172" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018111", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011198" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018111", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004220" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004231" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0016886" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0018135", "pred" : "is_a", @@ -81517,6 +154062,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0018135", "pred" : "http://purl.obolibrary.org/obo/RO_0000086", "obj" : "http://purl.obolibrary.org/obo/PATO_0002462" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018142", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018142", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010913" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018142", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006076" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0018150", "pred" : "is_a", @@ -81525,6 +154082,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0018150", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001835" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018151", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001458" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018151", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1000021" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018151", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001834" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018234", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003891" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018234", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0018239", "pred" : "is_a", @@ -81569,6 +154146,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0018260", "pred" : "http://purl.obolibrary.org/obo/RO_0002473", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002385" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018261", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006660" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018261", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018261", + "pred" : "http://purl.obolibrary.org/obo/RO_0002216", + "obj" : "http://purl.obolibrary.org/obo/GO_0030432" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018415", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018415", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0013685" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018415", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001679" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018543", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000464" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018543", + "pred" : "http://purl.obolibrary.org/obo/RO_0002572", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0018544", "pred" : "is_a", @@ -81601,6 +154210,38 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0018674", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000948" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034929" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001137" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "pred" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018707", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000489" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018707", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0009856" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018707", + "pred" : "http://purl.obolibrary.org/obo/RO_0000086", + "obj" : "http://purl.obolibrary.org/obo/PATO_0002468" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0018707", + "pred" : "http://purl.obolibrary.org/obo/RO_0001015", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000463" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0019042", "pred" : "is_a", @@ -81625,6 +154266,26 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0019189", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0005396" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000414" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0005181" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0036225" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002048" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0019204", "pred" : "is_a", @@ -81697,6 +154358,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0022288", "pred" : "http://purl.obolibrary.org/obo/RO_0002007", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010230" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0022292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001980" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0022292", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003497" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0022292", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0022293", "pred" : "is_a", @@ -81965,6 +154638,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0034929", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034932", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000483" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034932", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002294" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0034933", "pred" : "is_a", @@ -81977,6 +154658,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0034944", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000064" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000174" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034945", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034873" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034946", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0034945" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0034946", + "pred" : "http://purl.obolibrary.org/obo/RO_0003001", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001555" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0034947", "pred" : "is_a", @@ -82009,6 +154706,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0035037", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0011595" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035039", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035039", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0035050", "pred" : "is_a", @@ -82065,6 +154770,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0035546", "pred" : "http://purl.obolibrary.org/obo/RO_0002179", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001768" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035548", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035548", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0035549", "pred" : "is_a", @@ -82169,6 +154882,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0035804", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0000930" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035805", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012489" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0035805", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0035809", "pred" : "is_a", @@ -82317,6 +155038,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0036186", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_0011824" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036214", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410024" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036214", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036214", + "pred" : "http://purl.obolibrary.org/obo/RO_0002176", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0036215", "pred" : "is_a", @@ -82437,6 +155170,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0036294", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001833" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036301", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002201" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036301", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0006876" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036301", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0036302", "pred" : "is_a", @@ -82449,6 +155194,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0036303", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001017" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036343", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0003697" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036343", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036343", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002110" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0036351", "pred" : "is_a", @@ -82465,6 +155222,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0036352", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001533" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036362", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001169" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036362", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004121" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0036362", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0036422", "pred" : "is_a", @@ -82497,6 +155266,22 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0036925", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0010230" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000060" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000075" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0010313" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001697" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0037094", "pred" : "is_a", @@ -82525,6 +155310,46 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_0037144", "pred" : "http://purl.obolibrary.org/obo/RO_0002371", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004292" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015796" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0015482" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001152" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039228", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001638" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039228", + "pred" : "http://purl.obolibrary.org/obo/RO_0002179", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039228", + "pred" : "http://purl.obolibrary.org/obo/RO_0002376", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001215" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039261", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001637" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039261", + "pred" : "http://purl.obolibrary.org/obo/RO_0002178", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_0039261", + "pred" : "http://purl.obolibrary.org/obo/RO_0002252", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001194" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_0039856", "pred" : "is_a", @@ -82553,6 +155378,18 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_1000021", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0001456" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_1000024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000353" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_1000024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004120" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_1000024", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_1100000", "pred" : "is_a", @@ -82561,6 +155398,10 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_1100000", "pred" : "http://purl.obolibrary.org/obo/RO_0002176", "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_2001073", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002049" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_2001457", "pred" : "is_a", @@ -82605,6 +155446,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_3000977", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002100" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_3000982", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_3000961" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_3000982", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0007812" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_3010200", "pred" : "is_a", @@ -82669,6 +155518,154 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_8000009", "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", "obj" : "http://purl.obolibrary.org/obo/UBERON_0002354" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000042" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400021", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400021", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400023", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400023", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0012375" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8400023", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002107" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410001", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001979" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410001", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410004", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001980" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410004", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001213" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410008", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001979" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410008", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410009", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001980" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410009", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410015", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001980" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410015", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410024", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_1100000" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410024", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410043", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410077" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410043", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002185" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410048", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001979" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410048", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004921" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000051", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001245" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410056", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001982" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410056", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_8410050" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410057", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001982" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410057", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001155" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410068", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0001982" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410068", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0002108" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0004119" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011148" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0036225" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000065" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_8410081", "pred" : "is_a", @@ -82757,6 +155754,14 @@ "sub" : "http://purl.obolibrary.org/obo/UBERON_8600006", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/UBERON_8600004" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8600012", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0014717" + }, { + "sub" : "http://purl.obolibrary.org/obo/UBERON_8600012", + "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0011148" }, { "sub" : "http://purl.obolibrary.org/obo/UBERON_8600017", "pred" : "is_a", @@ -82849,6 +155854,10 @@ "sub" : "http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into", "pred" : "subPropertyOf", "obj" : "http://purl.obolibrary.org/obo/RO_0002170" + }, { + "sub" : "http://purl.obolibrary.org/obo/uberon/core#layer_part_of", + "pred" : "subPropertyOf", + "obj" : "http://purl.obolibrary.org/obo/BFO_0000050" }, { "sub" : "http://purl.obolibrary.org/obo/uberon/core#posteriorly_connected_to", "pred" : "subPropertyOf", @@ -83096,6 +156105,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000115" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000083", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000084", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000542" ], @@ -83245,6 +156261,23 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030072" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000168", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000151" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030073" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000169", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030073" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000170", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000151" ], @@ -83252,6 +156285,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0070091" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000171", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002067" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000172", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000151" ], @@ -83259,6 +156299,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0070253" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000173", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000174", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000151" ], @@ -83395,6 +156442,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003126" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000319", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000151" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070254" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000329", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], @@ -83430,6 +156484,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001134" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000358", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004590" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000359", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], @@ -83465,6 +156526,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002100", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001017" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000412", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053", + "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001377" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000413", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], @@ -83893,6 +156961,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0035935" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000666", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053", + "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002064" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0000670", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000039" ], @@ -85017,6 +158092,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0043129" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002064", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000622" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001263" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002067", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], @@ -85045,6 +158127,26 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000222" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002079", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000083" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001064" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015106" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002080", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000083" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001263" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002087", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000738" ], @@ -85052,6 +158154,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/CL_4030045", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030141" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002088", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000710" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043134" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002092", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0001035" ], @@ -85108,6 +158217,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030224" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002195", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002202", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], @@ -85146,6 +158262,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0000053", "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002505" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002243", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001607" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002246", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000037" ], @@ -85167,6 +158290,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002253", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002563" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002254", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002563" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002262", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], @@ -85181,6 +158318,37 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002265", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002266", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002267", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002275", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000696" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000006" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002308", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], @@ -85336,6 +158504,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005742" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002504", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002521", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000136" ], @@ -85343,6 +158518,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002190" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002538", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000488" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004823" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002539", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000359" ], @@ -85399,6 +158581,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002012" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002563", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002570", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000134" ], @@ -85406,6 +158595,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001013" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002571", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000134" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002572", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000134" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002412" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002574", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002575", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000669" ], @@ -85511,6 +158721,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002658", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002659", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], @@ -85525,6 +158742,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002081" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0002680", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000696" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0005000", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000099" ], @@ -85572,6 +158796,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002062" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0008024", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000163" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0008028", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000540" ], @@ -85603,6 +158834,114 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005388" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009006", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009018", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000542" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011189" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009021", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011189" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009022", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001238" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009024", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009025", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009038", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000235" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009040", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007177" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009042", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009044", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000542" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001238" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009048", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000235" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009051", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000084" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009052", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009053", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011189" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009063", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009089", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000669" ], @@ -85610,6 +158949,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009094", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001639" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009097", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0008002" ], @@ -85617,6 +158963,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002491", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000068" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0009100", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001279" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0010001", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000499" ], @@ -85743,6 +159096,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002067" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0011108", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_0011115", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], @@ -85806,6 +159166,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007196" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0019020", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000488" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004822" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0019021", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000398" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001279" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_0019022", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000398" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006841" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000222", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000165" ], @@ -85834,6 +159215,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000275", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002504" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000276", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000275" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000279", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002504" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000280", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002504" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000285", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_1000280" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000286", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000192" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000303", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], @@ -85911,6 +159334,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002094" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000398", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001281" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000409", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000187" ], @@ -85946,6 +159376,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001979" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000415", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000428", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000723" ], @@ -86002,6 +159439,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002094" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000488", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000069" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002394" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1000490", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000077" ], @@ -86030,6 +159477,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002401" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001433", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000066" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001516", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000164" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001242" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001567", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002139" ], @@ -86044,6 +159505,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002012" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001572", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001576", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000076" ], @@ -86051,6 +159519,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002424" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001588", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001589", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001592", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001595", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001598", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001599", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000150" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_1001603", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000235" ], @@ -86177,6 +159687,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002100", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002298" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000051", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000053", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000055", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000451" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000063", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], @@ -86212,6 +159743,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002407" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000069", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000070", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000057" ], @@ -86233,6 +159771,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000095" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000074", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000738" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_2000080", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002570" ], @@ -86310,6 +159855,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004802" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033005", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000313" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410043" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033008", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002543" ], @@ -86331,6 +159883,30 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000114" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033020", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000319" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005203" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033022", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000319" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410043" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033037", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000319" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007196" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410077" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033054", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000000" ], @@ -86338,6 +159914,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002049" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/CL_4033061", + "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0000115" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006841" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/CL_4040004", "genusIds" : [ "http://purl.obolibrary.org/obo/CL_0002570" ], @@ -86387,6 +159970,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18154" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0000272", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18154" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0000278", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007049" ], @@ -86513,6 +160103,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000970" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001655", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004122" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001674", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005634" ], @@ -86527,6 +160124,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0044207" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001678", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0019725" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001704", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], @@ -86785,6 +160389,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000115" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001889", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0001935", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], @@ -87142,6 +160753,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002608", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000782" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0002384", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006955" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0002396", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -88180,6 +161798,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003381" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003222", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004126" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003225", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005064" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003227", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005066" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003228", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -88327,6 +161966,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", "fillerId" : "http://purl.obolibrary.org/obo/CL_2000022" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003309", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000169" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003310", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000171" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003311", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000173" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003312", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002275" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003313", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -88348,6 +162015,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004291" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003322", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000171" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003323", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000169" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003324", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000173" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003325", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048468" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002275" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0003341", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007018" ], @@ -88512,6 +162207,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060350" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005275", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32952" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005319", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005342", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005355", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005583", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005581" ], @@ -88589,6 +162312,55 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18154" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005977", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005978", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005979", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005978" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005980", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0005981", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005980" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006006", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006007", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006024", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -88596,6 +162368,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18085" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006027", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18085" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006082", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006094", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006109", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -88603,6 +162396,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005975" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006111", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006094" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006139", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], @@ -88617,6 +162417,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006308", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006309", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006308" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030262" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006325", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -88624,6 +162438,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0000785" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006401", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33697" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006412", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -88662,6 +162483,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006415" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006516", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17089" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006518", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], @@ -88683,6 +162511,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006694", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35341" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006699", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006706", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35341" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006811", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -88711,6 +162560,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006873", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0019725" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24867" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0006886", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -88905,6 +162761,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002344", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005773" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007039", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030163" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005773" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007040", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -89097,6 +162960,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001041" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007442", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007492", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -89104,6 +162974,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000925" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007494", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0007498", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -89177,6 +163054,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008202", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35341" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008206", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36235" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008284", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -89191,6 +163082,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0008283" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008320", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008347", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], @@ -89240,6 +163141,23 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0008645", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009057", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33694" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009059", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -89261,6 +163179,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17089" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009250", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_37163" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009251", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_37163" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009306", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0046903" ], @@ -89282,6 +163214,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32952" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009310", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32952" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009416", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], @@ -89334,6 +163273,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009746", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009749", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009786", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -89397,6 +163350,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0008152" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009894", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009895", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009896", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0009913", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -89620,6 +163594,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0022402" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010565", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0042180" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010566", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0042181" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010567", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0042182" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010594", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -89886,6 +163881,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0048243" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010710", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030574" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010711", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030574" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010712", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -90040,6 +164049,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0010818" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010827", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1904659" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010828", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1904659" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010829", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1904659" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010830", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -90075,6 +164105,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010893", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006694" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010894", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006694" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010906", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006006" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010907", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006006" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010927", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -90124,6 +164182,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0022402" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010962", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009250" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0010968", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -90544,6 +164609,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015075", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24867" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015106", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17544" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015125", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_3098" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015144", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015149", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015159", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18154" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015671", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -90551,6 +164658,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_15379" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015701", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17544" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015718", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35757" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015721", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_3098" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015774", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -90572,6 +164700,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32952" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015849", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015850", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -90600,6 +164735,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_61120" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0015932", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_61120" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016042", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016043", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009987" ], @@ -90628,6 +164777,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016052", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016053", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016054", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0016057", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042391" ], @@ -90722,6 +164892,9 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33853" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019098", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007610", "http://purl.obolibrary.org/obo/GO_0048609" ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019216", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -90729,6 +164902,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006629" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019218", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008202" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019219", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -90750,6 +164930,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000540" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019318", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019319", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019320", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019336", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33853" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019538", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], @@ -90757,6 +164965,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019614", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33566" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019725", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042592" ], @@ -90764,6 +164979,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000000" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0019752", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0021501", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], @@ -91267,6 +165489,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_1990904" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0022857", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0022884", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33694" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0022898", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0022857" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0023019", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007165" ], @@ -91361,6 +165604,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_25905" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030073", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0046903" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000009054" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030097", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], @@ -91403,6 +165653,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007155" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030163", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030182", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -91445,6 +165702,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16336" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030214", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16336" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030217", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -91585,6 +165849,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000192" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030573", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030574", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005581" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0030595", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006935" ], @@ -91746,6 +166024,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005886" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031016", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031017", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031018", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000016" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031022", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007097" ], @@ -91935,6 +166234,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0044249" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031329", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044248" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031330", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044248" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031331", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044248" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031333", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -92081,6 +166401,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", "fillerId" : "http://purl.obolibrary.org/obo/GO_0043226" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0031987", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0040011" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007626" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032024", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030073" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032057", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -92108,6 +166442,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032059" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032069", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004518" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032070", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004536" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032074", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004518" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032075", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004518" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032076", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004536" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032077", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0004536" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032101", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -92234,6 +166610,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0002062" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032364", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0055082" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_15379" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032365", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -92307,6 +166690,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0046907" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032409", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005215" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032410", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005215" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032411", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005215" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032412", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015075" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032413", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015075" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032414", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015075" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032418", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0051179" ], @@ -92356,6 +166781,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33697" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032782", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0046903" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032787", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35757" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032790", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022411" ], @@ -92370,6 +166809,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0120025" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032868", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042221" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000009054" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032869", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000009054" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032871", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -92419,6 +166872,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007017" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032890", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015849" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032891", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015849" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032892", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015849" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0032943", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], @@ -92629,6 +167103,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0009308" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033241", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009310" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033242", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009310" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033243", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009310" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033278", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], @@ -92667,6 +167162,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030141" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033500", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048878" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0033604", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -92785,6 +167287,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0043603" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034251", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043605" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034252", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043605" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034253", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043605" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034329", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -92893,6 +167416,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_61120" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034655", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_61120" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0034762", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -93103,6 +167633,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005576" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035622", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003704" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035628", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001152" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035645", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002504" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035701", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], @@ -93138,6 +167689,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000115" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035773", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030073" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0071333" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035774", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0035773" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035779", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -93152,6 +167717,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000025" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035844", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0035855", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -93320,6 +167892,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000094" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0036333", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048872" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0012003", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000182" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0036334", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048872" ], @@ -93334,6 +167913,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000451" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0036342", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0036484", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], @@ -93543,6 +168129,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_6495" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042159", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_6495" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042176", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030163" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042177", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030163" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042180", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042181", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042182", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17087" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042221", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], @@ -93571,6 +168199,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_72587" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042422", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_72587" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042423", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -93578,6 +168213,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33567" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042424", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33567" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042427", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -93592,6 +168234,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_350546" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042429", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_350546" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042430", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], @@ -93606,6 +168255,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24828" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042436", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24828" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042461", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], @@ -93648,6 +168304,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002299", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000540" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042589", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016020" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0042588" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042593", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048878" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042670", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -93676,6 +168346,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32988" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042887", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32988" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0042953", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -93836,6 +168513,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000586" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043085", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003824" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043086", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003824" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043133", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006939" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043134", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043133" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043143", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -93850,6 +168555,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33694" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043171", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_60466" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043227", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0043226" ], @@ -93983,6 +168695,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_25905" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043436", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35406" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043467", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006091" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043470", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043501", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0043500" ], @@ -94088,6 +168821,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32988" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043605", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_32988" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0043931", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0001503" ], @@ -94109,6 +168849,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032991" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044042", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_37163" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044057", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94130,6 +168877,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0050886" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044062", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007588" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044065", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94172,6 +168926,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044092", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003674" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044093", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003674" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044258", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044342", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0012003", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000169" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0044346", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], @@ -94690,6 +169472,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0010001" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045719", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005978" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045721", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006094" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045722", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006094" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045724", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94697,6 +169500,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060271" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045725", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005978" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045727", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94704,6 +169514,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006412" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045732", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030163" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045759", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94802,6 +169619,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006897" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045818", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005980" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045819", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005980" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045822", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -94998,6 +169829,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006139" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045939", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008202" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045940", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008202" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0045947", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -95075,6 +169920,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33853" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046394", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046395", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046530", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -95201,6 +170060,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0046667" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046676", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030073" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046716", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0019725" ], @@ -95278,6 +170144,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005622" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046942", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0046943", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0047496", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -95612,6 +170492,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0008150" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048520", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007610" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048521", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007610" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048522", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -95626,6 +170520,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0009987" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048536", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048539", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -96119,6 +171020,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000034" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048878", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042592" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0048880", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -96350,6 +171258,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0008150" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050790", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003824" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050793", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -96364,6 +171279,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0009987" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050795", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007610" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050796", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030073" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050801", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048878" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24867" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050804", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -96399,6 +171335,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0045202" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050810", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006694" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050832", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006952" ], @@ -96546,6 +171489,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0019233" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050994", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016042" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050995", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016042" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0050996", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016042" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051017", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -96560,6 +171524,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051033", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33697" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051035", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051046", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -96906,6 +171884,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", "fillerId" : "http://purl.obolibrary.org/obo/GO_0140013" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051336", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016787" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051345", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016787" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051346", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016787" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051402", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], @@ -96913,6 +171912,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000540" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051410", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0098754" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_51143" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0051445", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -97433,6 +172439,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000031" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0055082", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0019725" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0055085", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -97440,6 +172453,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0055088", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048878" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0055094", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], @@ -97494,6 +172514,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001007" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060021", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007375" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060037", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -97776,6 +172803,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0051641" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060343", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000440" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060344", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010183" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060345", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001265" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060347", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002511" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060348", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048513" ], @@ -97986,6 +173041,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060425" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060450", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060451", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0043133" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060452", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -98290,6 +173359,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005153" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060574", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0021700" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002299", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002563" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060575", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002563" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060576", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002563" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0060577", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], @@ -98646,6 +173736,41 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060978" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061008", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002423" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061009", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002394" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061010", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061011", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001175" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061017", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_1000488" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061024", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016043" ], @@ -98877,6 +174002,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030324" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061113", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061114", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0061138" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0061113" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061117", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -98884,6 +174023,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060419" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061130", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048646" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002297", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003922" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061140", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], @@ -98919,6 +174065,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002202" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061153", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005203" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061154", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], @@ -98940,6 +174093,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002012" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061178", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0035773" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061179", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0035773" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061181", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -99066,6 +174233,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0061343" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061383", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000440" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061384", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002511" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061385", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048144" ], @@ -99087,6 +174268,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000351" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061453", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002088" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061458", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -99101,6 +174289,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005764" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061469", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044342" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061484", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048872" ], @@ -99136,6 +174331,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002590", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005929" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061525", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061548", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -99234,6 +174436,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032432" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061580", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0011108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061581", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], @@ -99241,6 +174450,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000575" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061582", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0016477" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002565", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0002563" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0061626", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], @@ -99321,6 +174537,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007842" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0062012", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044281" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0062013", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044281" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0062014", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044281" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0062033", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -99376,6 +174613,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0032993" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0065009", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003674" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0065010", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0043227" ], @@ -99516,6 +174760,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64628" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070254", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0046903" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000912" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070255", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070254" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070256", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070254" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070257", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070254" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070285", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032502" ], @@ -99551,6 +174823,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0070341" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070365", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000182" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070366", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070365" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070367", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070365" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070368", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0070365" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070382", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030133" ], @@ -99614,6 +174914,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005604" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070857", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006699" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070858", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006699" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070859", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006699" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070873", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005977" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070874", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005977" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070875", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005977" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0070925", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022607" ], @@ -99656,6 +174998,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16646" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071331", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18133" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071333", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0071375", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], @@ -99932,6 +175288,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0070062" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072001", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048731" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001008" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072089", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], @@ -99967,6 +175330,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0010463" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072329", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35757" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072330", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35757" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072359", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], @@ -100008,6 +175385,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000057" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072560", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0021700" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002299", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000169" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072575", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050673" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0072576" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072576", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0072577", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], @@ -100406,6 +175804,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006886" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0090325", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0031987" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0090326", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050789" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0031987" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0090327", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0031987" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0090425", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030154" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000622" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0090435", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -100489,6 +175915,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000100" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097050", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000169" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097060", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0098590" ], @@ -100524,6 +175957,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002592", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005765" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097272", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048878" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28938" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097275", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0055082" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28938" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097284", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000182" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0097355", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -100750,6 +176204,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005886" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0098801", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003014" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0098840", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0046907" ], @@ -101219,6 +176680,19 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002608", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099546", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007268" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099547", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101280,6 +176754,42 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0098794" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099574", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007268" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099575", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042176" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098793" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007268" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099576", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0042176" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007268" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0099577", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101490,6 +177000,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0009887" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0110112", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005319" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0110113", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005319" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0110114", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005319" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0110116", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101602,6 +177133,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0043005" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120158", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030574" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120178", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006694" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_26764" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120186", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101616,6 +177161,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0071168" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120188", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032782" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120189", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032782" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120190", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032782" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0120222", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101693,6 +177259,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0042953" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140096", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0003824" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140097", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0003824" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_16991" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140098", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0003824" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33697" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140103", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0003824" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17089" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140131", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101775,6 +177369,82 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0006412" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140246", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140247", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098793" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140249", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140250", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0045202" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140251", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098793" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140252", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0098794" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0009056" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_36080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140318", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000000001" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140352", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], @@ -101832,6 +177502,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002588", "fillerId" : "http://purl.obolibrary.org/obo/GO_0043228" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140734", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0007588" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_28938" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0140962", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048871" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002332", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_24431" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_0150031", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101971,6 +177655,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001042" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_0170055", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_18059" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1900015", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -101992,6 +177683,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0002534" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1900076", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032869" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1900077", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032869" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1900078", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0032869" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1900115", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009966" ], @@ -102132,6 +177844,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0042742" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901142", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000009054" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901143", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/PR_000009054" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901148", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0010467" ], @@ -102146,6 +177872,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50994" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901161", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_50994" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901162", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -102356,6 +178089,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35352" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901565", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_35352" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901566", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -102391,6 +178131,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33822" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901616", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009056" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33822" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901617", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009058" ], @@ -102398,6 +178145,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004008", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33822" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901618", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0022857" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_33822" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901623", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -102426,6 +178180,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_60466" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901654", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17087" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901655", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_17087" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1901692", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -102748,6 +178516,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030261" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902369", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006401" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902414", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -102776,6 +178551,55 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0035418" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902488", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/CL_1000488" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902489", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006915" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0005026" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902494", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032991" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003824" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902495", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032991" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0022857" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902510", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006309" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902511", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006309" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902512", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006309" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1902513", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103259,6 +179083,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007076" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903412", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0050896" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_3098" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903413", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0070887" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_3098" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903429", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103287,6 +179125,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060170" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903510", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008152" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004007", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_37395" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903522", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103434,6 +179279,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_1903441" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903624", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006308" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903625", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006308" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903626", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006308" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903697", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103518,6 +179384,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0061337" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903825", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_64709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903828", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103602,6 +179478,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007585" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903943", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097284" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903944", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097284" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903945", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097284" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1903950", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103707,6 +179604,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_1904019" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904054", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990705" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904055", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990705" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904056", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990705" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904057", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103805,6 +179723,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0060612" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904192", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1902488" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904193", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1902488" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904194", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1902488" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904204", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103833,6 +179772,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002315", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000669" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904251", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008206" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904252", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008206" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904253", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0008206" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904269", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0099738" ], @@ -103840,6 +179800,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/GO_0031252" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904304", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0014831" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904305", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0014831" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904306", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0014831" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904341", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990765" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904342", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990765" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904343", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990765" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904344", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103861,6 +179863,48 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_1990768" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904347", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990770" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904348", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990770" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904349", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990770" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904350", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007039" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904351", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007039" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904352", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007039" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904375", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -103959,6 +180003,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0019228" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904484", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048856" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002296", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0012478" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904491", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -104029,6 +180080,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0048286" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904659", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_4167" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904675", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -104050,6 +180111,30 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0048103" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904680", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0005215" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_60466" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904691", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044342" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904692", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0044342" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904693", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0009653" ], @@ -104057,6 +180142,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002298", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001891" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904697", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990863" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904698", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990863" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904699", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1990863" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1904705", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -104323,6 +180429,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0042118" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905039", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006810" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002342", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0016020" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", + "fillerId" : "http://purl.obolibrary.org/obo/CHEBI_29067" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905063", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -104393,6 +180509,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_1905139" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905146", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0030163" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005764" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905147", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -104435,6 +180558,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0010324" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905165", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1905146" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905166", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1905146" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905167", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_1905146" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905207", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -104533,6 +180677,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0014033" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905298", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0060576" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905299", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0060576" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905300", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0060576" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1905304", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -105303,6 +181468,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002339", "fillerId" : "http://purl.obolibrary.org/obo/GO_0000785" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990351", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0032991" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0005215" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990502", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0021700" ], @@ -105310,6 +181482,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002299", "fillerId" : "http://purl.obolibrary.org/obo/GO_0031045" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990705", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0012003", + "fillerId" : "http://purl.obolibrary.org/obo/CL_1000488" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990748", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0098754" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000000" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990765", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006939" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990768", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008015" ], @@ -105317,6 +181510,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004786" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990770", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0006939" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000066", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990778", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008104" ], @@ -105331,6 +181531,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0004009", "fillerId" : "http://purl.obolibrary.org/obo/GO_0005773" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990863", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0012003", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000622" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_1990874", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0008283" ], @@ -105373,6 +181580,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0002213" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000074", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003323" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000077", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003323" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000078", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003323" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000106", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -105555,6 +181783,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0008585" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000226", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003310" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000227", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003310" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000228", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0003310" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000241", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -105646,6 +181895,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", "fillerId" : "http://purl.obolibrary.org/obo/GO_0051450" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000292", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030421" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000293", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030421" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000294", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030421" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000351", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -105954,6 +182224,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0097049" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000674", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002211", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000675", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002212", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000676", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097050" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2000690", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -106108,6 +182399,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002213", "fillerId" : "http://purl.obolibrary.org/obo/GO_0035935" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/GO_2001012", + "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0048762" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0072001" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/GO_2001014", "genusIds" : [ "http://purl.obolibrary.org/obo/GO_0065007" ], @@ -106425,6 +182723,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000165" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000168", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0013522" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000170", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0034925" ], @@ -106442,6 +182747,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0007585" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000174", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000463" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002353", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007588" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000179", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000463" ], @@ -106449,6 +182761,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002193" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000220", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002217" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001092" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001676" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000304", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], @@ -106463,6 +182785,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002491", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000108" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000317", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000320", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000326", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000328", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -106477,6 +182820,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000136" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000333", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001242" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000355", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -106519,6 +182869,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002219", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000389" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000397", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000409", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002365" ], @@ -106533,6 +182890,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002185" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000414", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002365" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000319" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0000415", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -106682,6 +183046,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", "fillerId" : "http://purl.obolibrary.org/obo/GO_0022600" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001008", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_8450002" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0097254" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001013", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002384" ], @@ -106710,6 +183081,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000154" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001073", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001074", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002553" ], @@ -106766,6 +183147,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000214" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001095", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0018142" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002481" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001096", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -106773,6 +183161,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001130", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000075" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010913" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001133", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002036" ], @@ -106804,6 +183199,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000926" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001138", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005617" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001143", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001145", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], @@ -106811,6 +183220,29 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000992" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001152", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002150", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002150", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001166", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009870" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001165" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0008858" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0008861" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001167", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -106818,6 +183250,51 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001168", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001169", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001170", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001173", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000062" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002294" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002394" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001176", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003703" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002150", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001177", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003703" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002150", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001115" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001178", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0022350" ], @@ -106845,6 +183322,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000992" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001193", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001194", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001199", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -106866,6 +183357,118 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001167" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001202", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001166" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001204", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001205", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001206", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001207", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001208", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001209", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001212", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011148" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001215", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005617" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001238", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000030" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001242", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001243", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001245", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000161" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001555" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001262", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001263", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009842" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001265", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000440" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001268", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007779" ], @@ -106880,6 +183483,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001277", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001278", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001280", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001281", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003909" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001366", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0022351" ], @@ -106991,6 +183622,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001769" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001607", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001769" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001612", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], @@ -107052,6 +183690,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001645" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001677", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002481" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001708", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010912" ], @@ -107059,6 +183704,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002576", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011595" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001709", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000475" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002551", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003277" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001710", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000475" ], @@ -107167,6 +183819,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000013" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001834", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001833" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001835", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001833" ], @@ -107195,6 +183854,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003126" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001902", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001915", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001986" ], @@ -107281,6 +183947,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002221", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000232" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001970", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001971", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], @@ -107316,6 +183989,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001978", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001980", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001981" ], @@ -107350,6 +184030,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000115" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0001988", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000174" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002353", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0030421" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002012", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], @@ -107367,6 +184054,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002029", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002031", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -107589,6 +184283,19 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000915" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002294", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011216" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001173" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0006699" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002215", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0015721" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002299", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003215" ], @@ -107638,6 +184345,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000916" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002347", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015008" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002481" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002349", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005983" ], @@ -107707,6 +184421,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000187" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002394", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001173" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002400", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], @@ -107758,6 +184479,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002425" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002412", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002481" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002413", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002481" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002419", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], @@ -107793,6 +184528,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002240" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002466", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002469", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -107821,6 +184563,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/GO_0071953" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002561", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002558" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001017" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0002616", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000481" ], @@ -107883,6 +184632,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000965" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003086", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002252", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005805" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003104", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000479" ], @@ -107932,6 +184691,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000992" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003235", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003236", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -107959,6 +184725,26 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000925" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003259", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000490" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000925" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003260", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000490" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000925" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003269", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001134" ], @@ -107966,6 +184752,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000019" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003277", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010912" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002576", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003278", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010912" ], @@ -107980,6 +184773,34 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003126" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003281", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003282", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000948" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003283", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003284", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003294", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], @@ -108029,6 +184850,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001040" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003323", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003324", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -108036,6 +184864,55 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001710" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003329", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003330", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003331", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003332", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003334", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003335", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003336", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003338", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000045" ], @@ -108050,6 +184927,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001017" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003342", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003343", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -108057,6 +184941,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000166" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003346", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003350", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -108071,6 +184962,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001042" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003352", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003353", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003354", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003364", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -108169,6 +185081,41 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002402" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003393", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001008" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003394", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003395", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003396", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003397", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003406", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007844" ], @@ -108232,6 +185179,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002224" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003452", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001133" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002511" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003457", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], @@ -108267,6 +185221,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001004" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003470", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001834" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003471", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], @@ -108288,6 +185249,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001004" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003477", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001834" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003478", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], @@ -108302,6 +185270,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002224" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003481", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003489", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001915" ], @@ -108421,6 +185396,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002224" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003524", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001981" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003526", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001982" ], @@ -108435,6 +185417,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000955" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003534", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000014" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003536", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002173" ], @@ -108561,6 +185550,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002224" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003599", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002384" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003601", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007844" ], @@ -108666,6 +185662,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001004" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003665", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0014892" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002371", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001095" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003684", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -108683,6 +185686,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002570", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001896" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003694", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000982" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001092" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001093" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003697", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -108690,6 +185703,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000916" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003704", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002394" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003714", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000479" ], @@ -108875,6 +185895,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002323" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003894", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003898", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001134" ], @@ -108910,6 +185937,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004582" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003921", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0003928", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], @@ -109021,6 +186055,40 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000924" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004122", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000467" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000990" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001008" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004123", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#layer_part_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002349" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004124", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004123" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002165" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0036194" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004126", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004124" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002082" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004142", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002099" ], @@ -109069,6 +186137,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001137" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004220", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004221", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004222", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], @@ -109090,6 +186172,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004231", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001353" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004233", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], @@ -109118,6 +186207,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001981" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004238", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004239", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004240", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004242", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], @@ -109232,6 +186342,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004708" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004451", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002412" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000096", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001095" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004455", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000468" ], @@ -109263,6 +186380,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000974" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004468", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001015" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002371", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001130" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004469", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001015" ], @@ -109347,6 +186471,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002188" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004518", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0014892" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002371", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002412" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004521", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], @@ -109361,6 +186492,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002204" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004525", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003452" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004526", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003452" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002084" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004535", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000467" ], @@ -109538,6 +186683,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002067" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004760", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004764", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002481" ], @@ -109587,6 +186739,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004781", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000030" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004782", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], @@ -109594,6 +186753,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004783", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004784", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -109615,6 +186781,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004790", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000414" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002097" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004792", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000016" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004793", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004794", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], @@ -109622,6 +186809,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004795", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004797", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], @@ -109657,6 +186851,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001558" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004820", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002394" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004821", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -109664,6 +186865,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002299" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004822", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003703" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004823", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003704" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004830", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001134" ], @@ -109678,6 +186893,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004832", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001134" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001353" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004833", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001134" ], @@ -109685,6 +186907,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001833" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004834", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005171" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004848", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001917" ], @@ -109713,6 +186942,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004535" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004854", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004857", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002384" ], @@ -109748,6 +186984,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000966" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004867", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002553" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001697" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004883", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -109810,6 +187053,30 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000992" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004913", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001174" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004914" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004915", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004913" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004916", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001353" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004921", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0013522" ], @@ -109824,6 +187091,76 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001042" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004926", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001152" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004932", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004934", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001161" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004936", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001165" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004937", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001166" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004938", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001173" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004939", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001174" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004940", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001175" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004941", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001176" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004942", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001177" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004952", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], @@ -109831,6 +187168,83 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002186" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004988", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001152" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004993", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004995", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001161" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004997", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001165" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004998", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001166" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0004999", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001173" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005000", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001174" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005001", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001175" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005002", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001176" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005003", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001177" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005031", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001834" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005032", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -109838,6 +187252,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001835" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005033", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005039", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -109880,6 +187301,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002193" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005064", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004126" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002084" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005066", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004126" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002080" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005076", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], @@ -109960,6 +187395,37 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000915" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005203", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011148" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003126" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005221", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005222", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001115" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005233", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000924" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004068" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005234", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000924" ], @@ -110099,6 +187565,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003902" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005446", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0013685" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001677" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002570", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000377" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005460", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005487" ], @@ -110151,6 +187627,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001804" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005616", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005617", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005637", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001166" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005638", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -110200,6 +187697,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002168" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005685", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002296" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005688", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -110221,6 +187725,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004348" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005711", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003397" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001041" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005712", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003397" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005720", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004582" ], @@ -110270,6 +187788,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000061" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005845", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005844" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006071" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005865", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005856" ], @@ -110333,6 +187858,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000948" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005988", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000440" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002302" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0005989", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002099" ], @@ -110357,6 +187889,41 @@ "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000122", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000033" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006068", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006072", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005434" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006073", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000915" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006076", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006071" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006077", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000075" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001130" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006207", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002099" ], @@ -110367,6 +187934,30 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002220", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005805" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006227", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001679" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006235", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001041" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006236", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000209" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006239", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000043" ], @@ -110374,6 +187965,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006670" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006242", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006264", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], @@ -110384,6 +187982,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002131", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001041" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006271", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0013685" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001697" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006279", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003914" ], @@ -110446,6 +188051,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001004" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006555", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000025" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001008" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006563", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002522" ], @@ -110467,6 +188079,30 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002080" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006570", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002511" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002080" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006571", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002511" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002084" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006574", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000931" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006595", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006598" ], @@ -110521,6 +188157,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000483" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006686", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001130" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006761", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], @@ -110538,6 +188181,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000150" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006828", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002511" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002081" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006833", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -110559,6 +188209,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000062" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006877", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0006904", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005253" ], @@ -110709,6 +188366,41 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002100" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007147", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001045" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007148", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007158", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007159", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007177", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000030" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000317" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007188", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001136" ], @@ -110891,6 +188583,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000026" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007329", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002170", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007376", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -110943,6 +188645,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0000086", "fillerId" : "http://purl.obolibrary.org/obo/PATO_0001987" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007521", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000192" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007522", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/CL_0000737" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007530", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -110992,6 +188708,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001896" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007652", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007719", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], @@ -111033,6 +188756,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000916" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007812", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002415" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006071" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007823", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000475" ], @@ -111040,6 +188770,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002551", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010719" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007826", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002358" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0007828", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], @@ -111102,6 +188839,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007844" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008193", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010528" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008196", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0014892" ], @@ -111137,6 +188881,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410081" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008342", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001213" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008346", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008397", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -111179,6 +188937,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004364" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008856", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001167" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008861", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000325" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001166" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008870", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], @@ -111221,6 +188993,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002168" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0008989", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011148" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009015", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000014" ], @@ -111263,6 +189042,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007811" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009191", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005866" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009193", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002418" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009204", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004068" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009479", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000924" ], @@ -111277,6 +189077,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006211" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009482", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009483", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002095" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006235" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009494", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111284,6 +189098,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002539" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009497", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009501", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004066" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009503", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001046" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009505", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111291,6 +189126,61 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003126" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009521", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000490" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000925" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009526", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005868" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009548", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001281" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001115" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009549", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001281" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009550", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000925" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009566", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009568", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006077" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002100" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#subdivision_of", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002100" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009570", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005478" ], @@ -111361,6 +189251,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001891" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009621", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002329" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002415" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009652", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005769" ], @@ -111396,6 +189293,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002028" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009669", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000163" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009670", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009712", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001081" ], @@ -111424,6 +189335,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000948" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009752", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009758", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000045" ], @@ -111454,6 +189372,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0000086", "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002422" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009846", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000163" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009854", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009856" ], @@ -111502,6 +189427,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002385", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001785" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0009970", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007329" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010000", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ], @@ -111533,6 +189465,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004362" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010045", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007238" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010047", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], @@ -111540,6 +189479,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000165" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010081", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003703" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001175" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010083", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111575,6 +189521,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002149" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010152", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000912" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004790" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010161", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -111582,6 +189535,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001981" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010162", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011676" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0001108", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010183", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000440" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010192", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004573" ], @@ -111589,6 +189556,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000991" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010204", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010243", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002365" ], @@ -111606,6 +189580,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002342" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010253", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010045" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002342" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010256", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111643,6 +189627,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002342" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010276", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001130" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010294", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001986" ], @@ -111713,6 +189704,26 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005631" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010334", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002342" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010335", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009526" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006904" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010336", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111733,6 +189744,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006904" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010338", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010045" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006904" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010339", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111807,6 +189828,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000924" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010375", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009708" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010376", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010377", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003104" ], @@ -111827,6 +189862,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004873" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010399", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001265" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010400", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001265" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010499", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010498" ], @@ -111834,6 +189883,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", "fillerId" : "http://purl.obolibrary.org/obo/CL_0000067" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010527", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002558" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001474" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0010708", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010707" ], @@ -111883,6 +189939,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0008895" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011094", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002418" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011095", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005866" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011108", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002217" ], @@ -111890,6 +189960,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001421" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011148", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000414" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0001025", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000009" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011164", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], @@ -111897,6 +189974,44 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001703" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011171", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000982" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003277" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003278" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011185", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005409" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011189", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000030" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011198", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000059" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011201", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011215", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005162" ], @@ -111949,6 +190064,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002551", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001708" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011597", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001709" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011642", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -111959,6 +190081,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000924" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011677", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002412" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009568" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011695", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004535" ], @@ -111973,6 +190102,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004768" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011773", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011597" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011777", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000125" ], @@ -112059,6 +190195,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001777" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011878", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011919", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003061" ], @@ -112073,6 +190216,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006924" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011955", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001143" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001115" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0011956", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001143" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012054", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002553" ], @@ -112080,6 +190237,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003082" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012071", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001474" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007375" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012172", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001048" ], @@ -112136,6 +190300,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011595" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012367", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012375", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], @@ -112167,6 +190338,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/uberon/core#site_of", "fillerId" : "http://purl.obolibrary.org/obo/GO_0030097" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012463", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012464", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000161" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012465", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006866" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012466", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -112188,6 +190380,76 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002576", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010708" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012478", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012480", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012481", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012482", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000009" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012483", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012485", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0012423" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012486", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012488", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012489", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012490", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012504", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005742" ], @@ -112195,6 +190457,23 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012650", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0012651", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0012650" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013126", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], @@ -112216,6 +190495,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004581" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013158", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002530" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006235" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013212", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000456" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004760" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013232", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009842" ], @@ -112237,6 +190530,55 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013501", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004590" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013503", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0018142" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002418" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013504", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0018142" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005866" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013505", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002418" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013506", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015007" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005866" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013507", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015008" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002418" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013508", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0015008" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005866" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013514", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -112251,6 +190593,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000945" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013636", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001213" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013685", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005744" ], @@ -112265,6 +190614,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000955" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013695", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001986" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013697", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0013700", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001015" ], @@ -112348,6 +190711,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003909" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014400", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0014399" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001281" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014402", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ], @@ -112413,6 +190783,23 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003038" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014702", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004066" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014703", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000490" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001353" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002202", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000924" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014704", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], @@ -112430,6 +190817,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002170", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0009911" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014717", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009842" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000414" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014719", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000058" ], @@ -112461,6 +190855,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006241" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014783", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001630" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000162" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0014793", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001015" ], @@ -112498,6 +190899,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002049" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015007", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006072" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015008", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006073" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015129", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001013" ], @@ -112556,6 +190971,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000126", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000465" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015280", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007324" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000120", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015281", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007324" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000121", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000017" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015329", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005769" ], @@ -112563,6 +190992,37 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001004" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015481", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001193" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001115" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015482", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001193" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001114" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015485", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002394" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015716", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015783", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], @@ -112570,6 +191030,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002072" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015796", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001981" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015808", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -112584,6 +191051,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001041" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0015834", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000030" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016405", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001982" ], @@ -112601,6 +191075,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002570", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001043" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016478", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003891" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016490", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001032" ], @@ -112615,6 +191096,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002080" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016512", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002114" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016513", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002553" ], @@ -112653,6 +191141,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002020" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016552", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000912" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000065" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016553", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000912" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004785" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016570", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0022303" ], @@ -112660,6 +191162,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002315" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016854", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000481" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0003072" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016879", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006598" ], @@ -112674,6 +191183,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002387", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001016" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016885", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006866" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0016886", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002385" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006866" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0017650", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0005423" ], @@ -112688,6 +191211,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000916" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018111", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018112", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001135" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018135", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011824" ], @@ -112695,6 +191232,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0000086", "fillerId" : "http://purl.obolibrary.org/obo/PATO_0002462" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018142", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0010913" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0006076" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018150", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000014" ], @@ -112702,6 +191246,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001835" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018151", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000014" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001834" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018234", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0003891" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018239", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], @@ -112723,6 +191281,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002385" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018261", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001555" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018415", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004111" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001679" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018543", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000464" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018544", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001630" ], @@ -112744,6 +191323,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000948" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0018692", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0034929" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0015101", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0019042", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000344" ], @@ -112765,6 +191351,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0005396" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0019190", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000414" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0019204", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], @@ -112807,6 +191400,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002007", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010230" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0022292", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001980" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0022293", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000463" ], @@ -112913,6 +191513,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002572", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002530" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0034932", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000483" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002294" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0034933", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004923" ], @@ -112920,6 +191527,20 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001135" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0034945", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0034873" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002353", + "fillerId" : "http://purl.obolibrary.org/obo/GO_0007588" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0034946", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0034945" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0003001", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001555" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0034947", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0034873" ], @@ -112948,6 +191569,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011595" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035039", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035118", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ], @@ -112983,6 +191611,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001768" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035548", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035549", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], @@ -113039,6 +191674,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002048" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035805", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006660" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0035809", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002553" ], @@ -113108,6 +191750,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/RO_0002473", "fillerId" : "http://purl.obolibrary.org/obo/GO_0071953" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036214", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036217", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0006314" ], @@ -113192,6 +191844,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001833" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036301", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036303", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0002049" ], @@ -113199,6 +191858,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001017" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036343", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002110" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036351", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -113213,6 +191879,16 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001533" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036362", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001007" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0036422", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -113234,6 +191910,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0010230" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0037089", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001697" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0037094", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000060" ], @@ -113248,6 +191931,27 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000948" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0039222", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001152" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0039228", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001638" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002179", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001159" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0039261", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001637" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002178", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001264" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_0039856", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001145" ], @@ -113269,6 +191973,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001456" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_1000024", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000353" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002106" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_1100000", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], @@ -113304,6 +192015,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002100" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_3000982", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_3000961" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0007812" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_3010200", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001981" ], @@ -113342,6 +192060,120 @@ "propertyId" : "http://purl.obolibrary.org/obo/BSPO_0000121", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000468" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8400021", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000042" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8400023", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0012375" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002107" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410001", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001979" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001213" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410004", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001980" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001213" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410008", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001979" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410009", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001980" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410015", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001980" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410024", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0007651" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000160" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/RO_0002176", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0004921" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410043", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011148" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002185" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410048", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001979" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410050", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0004921" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000159" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001052" + }, { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000051", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001245" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410056", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001982" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_8410050" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410057", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001982" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0001155" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410068", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001982" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0002108" + } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8410077", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0011148" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000065" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8450002", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000467" ], @@ -113384,6 +192216,13 @@ "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0000991" } ] + }, { + "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8600012", + "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0009842" ], + "restrictions" : [ { + "propertyId" : "http://purl.obolibrary.org/obo/BFO_0000050", + "fillerId" : "http://purl.obolibrary.org/obo/UBERON_0011148" + } ] }, { "definedClassId" : "http://purl.obolibrary.org/obo/UBERON_8600024", "genusIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001979" ], @@ -113438,6 +192277,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0002250", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0002384", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0002443", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113466,6 +192309,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0005929", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_2759" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0006699", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0006915", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113502,6 +192349,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0007565", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_40674" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0007610", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0008347", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113546,6 +192397,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0021535", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_89593" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030073", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030097", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113558,6 +192413,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0035805", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0036342", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7711" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0040007", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113678,10 +192537,18 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0099536", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099546", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0099547", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0099574", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0099643", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", @@ -113698,10 +192565,26 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0140243", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140246", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0140250", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0150077", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990765", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_1990770", + "pred" : "http://purl.obolibrary.org/obo/RO_0002162", + "obj" : "http://purl.obolibrary.org/obo/NCBITaxon_7742" }, { "sub" : "http://purl.obolibrary.org/obo/GO_2001222", "pred" : "http://purl.obolibrary.org/obo/RO_0002162", diff --git a/clm.obo b/clm.obo index 47d557f..e766b0e 100644 --- a/clm.obo +++ b/clm.obo @@ -1,12 +1,13 @@ format-version: 1.2 -data-version: releases/2024-07-26 +data-version: releases/2024-07-29 idspace: dce http://purl.org/dc/elements/1.1/ idspace: dcterms http://purl.org/dc/terms/ +idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# ontology: clm property_value: dcterms:description "None" xsd:string property_value: dcterms:license https://creativecommons.org/licenses/unspecified property_value: dcterms:title "Cell Markers Ontology" xsd:string -property_value: owl:versionInfo "2024-07-26" xsd:string +property_value: owl:versionInfo "2024-07-29" xsd:string [Term] id: CHEBI:24431 @@ -19,6 +20,17 @@ equivalent_to: PR:000000001 [Term] id: CL:0000000 name: cell +def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] +comment: A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26. {xref="https://doi.org/10.5281/zenodo.11165918"} +comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). +xref: CALOHA:TS-2035 +xref: FMA:68646 +xref: GO:0005623 +xref: KUPO:0000002 +xref: MESH:D002477 +xref: VHOG:0001533 +xref: WBbt:0004017 +xref: XAO:0003012 is_a: UBERON:0000061 ! anatomical structure disjoint_from: GO:0031012 ! extracellular matrix disjoint_from: GO:0032991 ! protein-containing complex @@ -26,10 +38,12 @@ disjoint_from: GO:0043226 ! organelle relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001407", gci_relation="RO:0000053"} ! has part nucleus relationship: BFO:0000051 GO:0005634 {gci_filler="PATO:0001908", gci_relation="RO:0000053"} ! has part nucleus relationship: RO:0002160 NCBITaxon:131567 ! cellular organisms +relationship: RO:0015004 CL:4037006 ! has characterizing marker set NS forest marker set of cell (Human Lung). [Term] id: CL:0000005 name: neural crest derived fibroblast +def: "Any fibroblast that is derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell @@ -38,6 +52,7 @@ relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell +def: "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception." [FBC:Autogenerated] is_a: CL:0000101 ! sensory neuron is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell @@ -47,21 +62,25 @@ intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involv [Term] id: CL:0000007 name: early embryonic cell (metazoa) +def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm] is_a: CL:0002321 ! embryonic cell (metazoa) [Term] id: CL:0000008 name: migratory cranial neural crest cell +def: "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007091] is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000011 name: migratory trunk neural crest cell +def: "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007095] is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000014 name: germ line stem cell +def: "A stem cell that is the precursor of gametes." [doi:10.1016/j.stem.2012.05.016] is_a: CL:0000034 ! stem cell is_a: CL:0000039 ! germ line cell intersection_of: CL:0000039 ! germ line cell @@ -70,6 +89,10 @@ intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division [Term] id: CL:0000021 name: female germ cell +def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446] +xref: MA:0000388 +xref: ncithesaurus:Egg +xref: VHOG:0001530 is_a: CL:0000586 ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0002215 GO:0048477 ! capable of oogenesis @@ -78,6 +101,7 @@ relationship: RO:0002215 GO:0048477 ! capable of oogenesis [Term] id: CL:0000022 name: female germ line stem cell +def: "A stem cell that is the precursor of female gametes." [doi:10.1016/j.stem.2012.05.016] is_a: CL:0000014 ! germ line stem cell is_a: CL:0000021 ! female germ cell intersection_of: CL:0000021 ! female germ cell @@ -86,6 +110,12 @@ intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division [Term] id: CL:0000023 name: oocyte +def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544] +xref: BTO:0000964 +xref: CALOHA:TS-0711 +xref: FMA:18644 +xref: MESH:D009865 +xref: WBbt:0006797 is_a: BFO:0000002 is_a: CL:0000021 ! female germ cell is_a: CL:0000255 ! eukaryotic cell @@ -95,6 +125,8 @@ relationship: RO:0002160 NCBITaxon:33208 ! Metazoa [Term] id: CL:0000024 name: oogonial cell +def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544] +xref: FMA:83673 is_a: BFO:0000002 is_a: CL:0000021 ! female germ cell intersection_of: CL:0000021 ! female germ cell @@ -105,6 +137,12 @@ relationship: RO:0002215 GO:0000278 ! capable of mitotic cell cycle [Term] id: CL:0000025 name: egg cell +def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544] +xref: BTO:0000369 +xref: BTO:0003801 +xref: CALOHA:TS-2191 +xref: FMA:67343 +xref: MESH:D010063 is_a: BFO:0000002 is_a: CL:0000675 ! female gamete relationship: RO:0000056 GO:0007143 ! participates in female meiotic nuclear division @@ -113,6 +151,7 @@ relationship: RO:0002202 CL:0000023 ! oocyte [Term] id: CL:0000027 name: smooth muscle cell neural crest derived +def: "A smooth muscle cell derived from the neural crest." [https://orcid.org/0000-0001-5208-3432] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell @@ -121,6 +160,7 @@ relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000029 name: neural crest derived neuron +def: "Any neuron that develops from some migratory neural crest cell." [FBC:Autogenerated] is_a: BFO:0000002 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron @@ -131,6 +171,9 @@ relationship: RO:0002202 CL:0002676 ! neural crest derived neuroblast [Term] id: CL:0000031 name: neuroblast (sensu Vertebrata) +def: "A cell that will develop into a neuron often after a migration phase." [GOC:NV, http://en.wikipedia.org/wiki/Neuroblast] +xref: BTO:0000930 +xref: FMA:70563 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -138,16 +181,21 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: CL:0000034 name: stem cell +def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:D013234] +comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. +xref: CALOHA:TS-2086 +xref: FMA:63368 is_a: CL:0011115 ! precursor cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0017145 ! capable of stem cell division relationship: RO:0002162 NCBITaxon:33208 ! Metazoa relationship: RO:0002215 GO:0017145 ! capable of stem cell division -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000035 name: single fate stem cell +def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm] +xref: FMA:70569 is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001400 ! bearer of @@ -157,6 +205,13 @@ relationship: RO:0000053 PATO:0001400 ! bearer of [Term] id: CL:0000037 name: hematopoietic stem cell +def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770] +comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. +xref: BTO:0000725 +xref: CALOHA:TS-0448 +xref: FMA:86475 +xref: MESH:D006412 +xref: VHOG:0001485 is_a: CL:0000723 ! somatic stem cell is_a: CL:0008001 ! hematopoietic precursor cell is_a: CL:0011026 ! progenitor cell @@ -189,11 +244,12 @@ relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part relationship: RO:0002202 CL:0000566 ! angioblastic mesenchymal cell relationship: RO:0002215 GO:0002244 ! capable of hematopoietic progenitor cell differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000038 name: erythroid progenitor cell +def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464] +xref: BTO:0004911 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell @@ -201,12 +257,18 @@ relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell [Term] id: CL:0000039 name: germ line cell +def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] +comment: Originally this term had some plant germ line cell children. is_a: CL:0000000 ! cell relationship: RO:0002215 GO:0022414 ! capable of reproductive process [Term] id: CL:0000040 name: monoblast +def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740] +comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. +xref: CALOHA:TS-1195 +xref: FMA:83553 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell @@ -224,6 +286,8 @@ relationship: RO:0002202 CL:0002009 ! macrophage dendritic cell progenitor [Term] id: CL:0000048 name: multi fate stem cell +def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add] +xref: FMA:84789 is_a: CL:0000034 ! stem cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001402 ! bearer of @@ -233,15 +297,19 @@ relationship: RO:0000053 PATO:0001402 ! bearer of [Term] id: CL:0000049 name: common myeloid progenitor +def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461] +comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). +xref: BTO:0004730 is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell disjoint_from: CL:0000051 ! common lymphoid progenitor disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell +def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566] +comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell @@ -252,44 +320,65 @@ disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation relationship: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000051 name: common lymphoid progenitor +def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251] +comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000052 name: totipotent stem cell +def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm] +xref: FMA:84790 +xref: MESH:D039901 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000055 name: non-terminally differentiated cell +def: "A precursor cell with a limited number of potential fates." [SANBI:mhl] +comment: define using PATO mulit-potent or oligopotent? +xref: BTO:0000125 +xref: FMA:84782 is_a: CL:0011115 ! precursor cell [Term] id: CL:0000056 name: myoblast +def: "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:D032446, PMID:21849021] +xref: BTO:0000222 +xref: CALOHA:TS-0650 +xref: FMA:70335 +xref: VHOG:0001529 is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000057 name: fibroblast +def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:D005347] +comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. +xref: BTO:0000452 +xref: CALOHA:TS-0362 +xref: FMA:63877 +xref: NCIT:C12482 +xref: VHOG:0001482 is_a: BFO:0000002 is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000058 name: chondroblast +def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256] +xref: BTO:0003607 +xref: FMA:66783 is_a: BFO:0000002 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell @@ -299,6 +388,9 @@ relationship: RO:0003000 UBERON:0002418 ! produces cartilage tissue [Term] id: CL:0000064 name: ciliated cell +def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm] +xref: VHOG:0001532 +xref: XAO:0000031 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000051 GO:0005929 ! has part cilium @@ -307,14 +399,21 @@ relationship: BFO:0000051 GO:0005929 ! has part cilium [Term] id: CL:0000066 name: epithelial cell +def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:D004847] +xref: BTO:0000414 +xref: CALOHA:TS-2026 +xref: CARO:0000077 +xref: FMA:66768 +xref: WBbt:0003672 is_a: CL:0000000 ! cell disjoint_from: CL:0000738 ! leukocyte relationship: BFO:0000050 UBERON:0000483 ! part of epithelium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000067 name: ciliated epithelial cell +def: "An epithelial cell that has a cilia." [GOC:tfm] +xref: FMA:70605 is_a: CL:0000064 ! ciliated cell is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell @@ -323,6 +422,7 @@ intersection_of: BFO:0000051 GO:0005929 ! has part cilium [Term] id: CL:0000068 name: duct epithelial cell +def: "An epithelial cell that is part of a duct." [https://orcid.org/0000-0001-5208-3432] is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000058 ! part of duct @@ -336,35 +436,38 @@ is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000071 name: blood vessel endothelial cell +def: "An endothelial cell that lines the vasculature." [GOC:tfm] is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0004638 ! part of blood vessel endothelium relationship: RO:0002202 CL:0002546 ! embryonic blood vessel endothelial progenitor cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell +def: "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GO:0002065, https://orcid.org/0000-0001-5208-3432] is_a: CL:0000066 ! epithelial cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000076 name: squamous epithelial cell +xref: CALOHA:TS-1249 is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000077 name: mesothelial cell +def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [GOC:tfm, ISBN:0721662544] +xref: FMA:66773 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000080 name: circulating cell +def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid @@ -373,6 +476,9 @@ relationship: BFO:0000050 UBERON:0000179 ! part of haemolymphatic fluid [Term] id: CL:0000081 name: blood cell +def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] +xref: FMA:62844 +xref: MESH:D001773 is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation @@ -381,24 +487,47 @@ relationship: RO:0002215 GO:0008015 ! capable of blood circulation [Term] id: CL:0000082 name: epithelial cell of lung +def: "An epithelial cell of the lung." [https://orcid.org/0000-0001-5208-3432] +xref: BTO:0004299 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000115 ! part of lung epithelium relationship: BFO:0000050 UBERON:0000115 ! part of lung epithelium +[Term] +id: CL:0000083 +name: epithelial cell of pancreas +def: "An epithelial cell of the pancreas." [GOC:tfm] +xref: BTO:0000028 +is_a: CL:0002076 ! endo-epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: CL:0000084 name: T cell +def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] +xref: BTO:0000782 +xref: CALOHA:TS-1001 +xref: FMA:62870 +xref: MESH:D013601 +xref: VHOG:0001479 is_a: CL:0000542 ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: RO:0002215 GO:0002456 ! capable of T cell mediated immunity relationship: RO:0002202 CL:0000827 ! pro-T cell relationship: RO:0002215 GO:0002456 ! capable of T cell mediated immunity -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000092 name: osteoclast +def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158] +comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. +xref: BTO:0000968 +xref: CALOHA:TS-0721 +xref: FMA:66781 +xref: MESH:D010010 is_a: CL:0000518 ! phagocyte (sensu Vertebrata) is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0001035 ! bone cell @@ -425,6 +554,11 @@ relationship: RO:0002215 GO:0045453 ! capable of bone resorption [Term] id: CL:0000094 name: granulocyte +def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:D006098] +xref: BTO:0000539 +xref: BTO:0001026 +xref: CALOHA:TS-0422 +xref: FMA:62854 is_a: CL:0000081 ! blood cell is_a: CL:0000766 ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte @@ -445,7 +579,6 @@ relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part relationship: RO:0002104 PR:000001012 relationship: RO:0002104 PR:000001332 relationship: RO:0002104 PR:000001969 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000095 @@ -457,6 +590,9 @@ relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0000098 name: sensory epithelial cell +def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] +comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). +xref: BTO:0004301 is_a: CL:0000066 ! epithelial cell is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000066 ! epithelial cell @@ -465,27 +601,39 @@ intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involv [Term] id: CL:0000099 name: interneuron +def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:D007395] +xref: BTO:0003811 +xref: FMA:67313 +xref: WBbt:0005113 is_a: CL:0000540 ! neuron -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000100 name: motor neuron +def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:D009046, PMID:16875686] +xref: BTO:0000312 +xref: FMA:83617 +xref: WBbt:0005409 is_a: CL:0000527 ! efferent neuron -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000101 name: sensory neuron +def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544] +xref: BTO:0001037 +xref: FMA:84649 +xref: MESH:D011984 +xref: WBbt:0005759 is_a: CL:0000526 ! afferent neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000107 name: autonomic neuron +def: "A neuron whose cell body is within an autonomic ganglion." [GOC:tfm] +xref: FMA:80121 is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0002410 ! autonomic nervous system @@ -494,19 +642,24 @@ relationship: RO:0002100 UBERON:0002410 ! autonomic nervous system [Term] id: CL:0000113 name: mononuclear phagocyte +def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149] +xref: BTO:0001433 is_a: CL:0000518 ! phagocyte (sensu Vertebrata) is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: RO:0000053 PATO:0001407 ! bearer of -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000115 name: endothelial cell +def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341] +comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. +xref: BTO:0001176 +xref: CALOHA:TS-0278 +xref: FMA:66772 is_a: BFO:0000002 is_a: CL:0000213 ! lining cell relationship: RO:0002202 CL:0000222 ! mesodermal cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000117 @@ -519,32 +672,49 @@ relationship: RO:0002202 CL:0000031 ! neuroblast (sensu Vertebrata) [Term] id: CL:0000125 name: glial cell +def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457] +comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 +xref: BTO:0002606 +xref: CALOHA:TS-0415 +xref: FMA:54536 is_a: CL:0000095 ! neuron associated cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000133 name: neurectodermal cell +def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X] is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000134 name: mesenchymal stem cell +def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544] +comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. +xref: BTO:0002625 +xref: BTO:0003298 +xref: FMA:70546 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000136 name: adipocyte +def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:D017667] +xref: BTO:0000443 +xref: CALOHA:TS-0012 +xref: FMA:63880 is_a: BFO:0000002 is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000138 name: chondrocyte +def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:D019902] +xref: BTO:0000249 +xref: CALOHA:TS-0138 +xref: FMA:66782 is_a: CL:0000153 ! glycosaminoglycan secreting cell is_a: CL:0000667 ! collagen secreting cell relationship: RO:0001025 UBERON:0002418 ! cartilage tissue @@ -553,6 +723,8 @@ relationship: RO:0002202 CL:0000058 ! chondroblast [Term] id: CL:0000145 name: professional antigen presenting cell +def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149] +comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: RO:0002215 GO:0002504 ! capable of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II @@ -561,6 +733,8 @@ relationship: RO:0002215 GO:0002504 ! capable of antigen processing and presenta [Term] id: CL:0000147 name: pigment cell +def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm] +xref: VHOG:0001678 is_a: CL:0000325 ! stuff accumulating cell [Term] @@ -571,6 +745,9 @@ is_a: CL:0000147 ! pigment cell [Term] id: CL:0000150 name: glandular epithelial cell +def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [GOC:tfm] +xref: CALOHA:TS-2085 +xref: FMA:86494 is_a: CL:0000066 ! epithelial cell is_a: CL:0000151 ! secretory cell relationship: BFO:0000050 UBERON:0006799 ! part of glandular epithelium @@ -578,6 +755,9 @@ relationship: BFO:0000050 UBERON:0006799 ! part of glandular epithelium [Term] id: CL:0000151 name: secretory cell +def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] +xref: BTO:0003659 +xref: FMA:86916 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0032940 ! capable of secretion by cell @@ -586,6 +766,8 @@ relationship: RO:0002215 GO:0032940 ! capable of secretion by cell [Term] id: CL:0000152 name: exocrine cell +def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684] +xref: FMA:16014 is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002365 ! part of exocrine gland @@ -594,12 +776,14 @@ relationship: BFO:0000050 UBERON:0002365 ! part of exocrine gland [Term] id: CL:0000153 name: glycosaminoglycan secreting cell +def: "A cell that secretes glycosaminoglycans." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell [Term] id: CL:0000154 name: protein secreting cell +def: "Any secretory cell that is capable of some protein secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0009306 ! capable of protein secretion @@ -608,6 +792,7 @@ relationship: RO:0002215 GO:0009306 ! capable of protein secretion [Term] id: CL:0000157 name: surfactant secreting cell +def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [GOC:tfm, ISBN:0721662544] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0043129 ! capable of surfactant homeostasis @@ -616,11 +801,13 @@ relationship: RO:0002215 GO:0043129 ! capable of surfactant homeostasis [Term] id: CL:0000158 name: club cell +def: "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium." [DOI:10.1183/09031936.00146609, DOI:10.1378/chest.12-2762, GOC:tfm, PMID:28128362, PMID:29874100, PMID:7905712] +xref: BTO:0004811 +xref: FMA:14119 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0011026 ! progenitor cell relationship: RO:0002104 GO:0005902 ! microvillus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000159 @@ -630,67 +817,161 @@ is_a: CL:0000151 ! secretory cell [Term] id: CL:0000163 name: endocrine cell +def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:D055098] +xref: FMA:83809 is_a: CL:0000151 ! secretory cell is_a: CL:0000164 {gci_filler="UBERON:0000945", gci_relation="BFO:0000050"} ! enteroendocrine cell +is_a: CL:0000164 {gci_filler="UBERON:0000160", gci_relation="BFO:0000050"} ! enteroendocrine cell +is_a: CL:0000164 {gci_filler="UBERON:0001264", gci_relation="BFO:0000050"} ! enteroendocrine cell relationship: BFO:0000050 UBERON:0000949 ! part of endocrine system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000164 name: enteroendocrine cell +def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl] +xref: BTO:0003865 +xref: FMA:62930 +xref: MESH:D019858 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000165 name: neuroendocrine cell +def: "A neuron that is capable of some hormone secretion in response to neuronal signals." [MESH:D055099] +comment: The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. {xref="https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073", xref="PMID:5342440"} +xref: BTO:0002691 +xref: FMA:83810 is_a: CL:0000163 ! endocrine cell is_a: CL:0000527 ! efferent neuron is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0046879 ! capable of hormone secretion -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000167 name: peptide hormone secreting cell +def: "Any secretory cell that is capable of some peptide hormone secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030072 ! capable of peptide hormone secretion relationship: RO:0002215 GO:0030072 ! capable of peptide hormone secretion +[Term] +id: CL:0000168 +name: insulin secreting cell +def: "Any secretory cell that is capable of some insulin secretion." [FBC:Autogenerated] +xref: BTO:0000783 +is_a: CL:0000154 ! protein secreting cell +is_a: CL:0000167 ! peptide hormone secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: RO:0002215 GO:0030073 ! capable of insulin secretion +relationship: RO:0002215 GO:0030073 ! capable of insulin secretion + +[Term] +id: CL:0000169 +name: type B pancreatic cell +def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651] +comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. +xref: BTO:0000783 +xref: EV:0200009 +xref: FMA:70586 +xref: MA:0002419 +xref: ncithesaurus:Beta_Cell +is_a: CL:0000168 ! insulin secreting cell +is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans +intersection_of: RO:0002215 GO:0030073 ! capable of insulin secretion +relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans +relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas + [Term] id: CL:0000170 name: glucagon secreting cell +def: "A cell that secretes glucagon." [GOC:tfm] +xref: FMA:84045 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070091 ! capable of glucagon secretion relationship: RO:0002215 GO:0070091 ! capable of glucagon secretion +[Term] +id: CL:0000171 +name: pancreatic A cell +def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544] +xref: BTO:0000990 +xref: FMA:70585 +xref: MESH:D050416 +is_a: CL:0002067 ! type A enteroendocrine cell +is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0002067 ! type A enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans +relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas + [Term] id: CL:0000172 name: somatostatin secreting cell +def: "Any secretory cell that is capable of some somatostatin secretion." [FBC:Autogenerated] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070253 ! capable of somatostatin secretion relationship: RO:0002215 GO:0070253 ! capable of somatostatin secretion +[Term] +id: CL:0000173 +name: pancreatic D cell +def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm] +xref: BTO:0000803 +xref: FMA:70587 +is_a: CL:0000502 ! type D enteroendocrine cell +is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans +relationship: RO:0002202 CL:0002351 ! progenitor cell of endocrine pancreas + [Term] id: CL:0000174 name: steroid hormone secreting cell +def: "Any secretory cell that is capable of some steroid hormone secretion." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035929 ! capable of steroid hormone secretion relationship: RO:0002215 GO:0035929 ! capable of steroid hormone secretion +[Term] +id: CL:0000182 +name: hepatocyte +def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:D022781, PMID:19717280] +comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. +xref: BTO:0000575 +xref: CALOHA:TS-0454 +xref: FMA:14515 +is_a: BFO:0000002 +is_a: CL:0000066 ! epithelial cell +is_a: CL:0000417 ! endopolyploid cell +relationship: BFO:0000050 UBERON:0002107 ! part of liver +relationship: RO:0002202 CL:0005026 ! hepatoblast +relationship: RO:0002215 GO:0006699 ! capable of bile acid biosynthetic process +relationship: RO:0002215 GO:0098754 ! capable of detoxification + [Term] id: CL:0000183 name: contractile cell +def: "A cell whose primary function is to shorten." [FB:ma] is_a: CL:0000000 ! cell [Term] id: CL:0000187 name: muscle cell +def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:D032342] +xref: BTO:0000888 +xref: BTO:0000902 +xref: CALOHA:TS-2032 +xref: FMA:67328 +xref: WBbt:0003675 is_a: BFO:0000002 is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell @@ -699,24 +980,31 @@ relationship: RO:0002202 CL:0000056 ! myoblast [Term] id: CL:0000188 name: cell of skeletal muscle +def: "A somatic cell located in skeletal muscle." [GOC:tfm] +xref: BTO:0004392 +xref: CALOHA:TS-2158 +xref: FMA:9727 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue relationship: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000192 name: smooth muscle cell +def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:D032389, PMID:9315361] +xref: BTO:0004576 +xref: CALOHA:TS-2159 +xref: FMA:14072 is_a: CL:0008000 ! non-striated muscle cell is_a: CL:0008007 ! visceral muscle cell relationship: RO:0002202 CL:0000514 ! smooth muscle myoblast -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000197 name: sensory receptor cell def: "A cell that is capable of detection of a stimulus involved in sensory perception." [] +xref: MESH:D011984 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001032 ! part of sensory system @@ -727,6 +1015,7 @@ relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved [Term] id: CL:0000206 name: chemoreceptor cell +def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:D002628] is_a: CL:0000197 ! sensory receptor cell intersection_of: CL:0000197 ! sensory receptor cell intersection_of: RO:0002215 GO:0050907 ! capable of detection of chemical stimulus involved in sensory perception @@ -735,6 +1024,10 @@ relationship: RO:0002215 GO:0050907 ! capable of detection of chemical stimulus [Term] id: CL:0000210 name: photoreceptor cell +def: "A cell specialized to detect and transduce light." [MESH:D010786] +xref: BTO:0001060 +xref: CALOHA:TS-0868 +xref: FMA:86740 is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050962 ! capable of detection of light stimulus involved in sensory perception @@ -743,17 +1036,20 @@ relationship: RO:0002215 GO:0050962 ! capable of detection of light stimulus inv [Term] id: CL:0000211 name: electrically active cell +def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma] is_a: CL:0000000 ! cell [Term] id: CL:0000213 name: lining cell +def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb] is_a: CL:0000215 ! barrier cell [Term] id: CL:0000214 name: synovial cell def: "A cell located in the synovial joint." [] +xref: CALOHA:TS-0995 is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell relationship: BFO:0000050 UBERON:0002217 ! part of synovial joint @@ -761,11 +1057,13 @@ relationship: BFO:0000050 UBERON:0002217 ! part of synovial joint [Term] id: CL:0000215 name: barrier cell +def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb] is_a: CL:0000000 ! cell [Term] id: CL:0000219 name: motile cell +def: "A cell that moves by its own activities." [FB:ma] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0048870 ! capable of cell motility @@ -774,24 +1072,31 @@ relationship: RO:0002215 GO:0048870 ! capable of cell motility [Term] id: CL:0000221 name: ectodermal cell +def: "A cell of the outer of the three germ layers of the embryo." [MESH:D004475] +xref: FMA:72549 is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm [Term] id: CL:0000222 name: mesodermal cell +def: "A cell of the middle germ layer of the embryo." [MESH:D008648] +xref: FMA:72554 is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm [Term] id: CL:0000223 name: endodermal cell +def: "A cell of the inner of the three germ layers of the embryo." [MESH:D004707] +xref: FMA:72555 is_a: CL:0002321 ! embryonic cell (metazoa) relationship: BFO:0000050 UBERON:0000925 ! part of endoderm [Term] id: CL:0000226 name: single nucleate cell +def: "A cell with a single nucleus." [FB:ma, GOC:tfm] is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001407 ! bearer of @@ -800,6 +1105,9 @@ relationship: RO:0000053 PATO:0001407 ! bearer of [Term] id: CL:0000228 name: multinucleate cell +def: "A cell with more than one nucleus." [FB:ma] +xref: AEO:0000203 +xref: WBbt:0008074 is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001908 ! bearer of @@ -808,6 +1116,10 @@ relationship: RO:0000053 PATO:0001908 ! bearer of [Term] id: CL:0000232 name: erythrocyte +def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:D004912] +xref: BTO:0000424 +xref: CALOHA:TS-0290 +xref: FMA:81100 is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 ! erythroid lineage cell @@ -821,11 +1133,14 @@ relationship: CL:4030045 GO:0005840 ! lacks_part ribosome relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part relationship: RO:0000053 PATO:0002039 ! bearer of relationship: RO:0002202 CL:0000558 ! reticulocyte -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000234 name: phagocyte +def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464] +xref: BTO:0001044 +xref: FMA:83806 +xref: MESH:D010586 is_a: CL:0000219 ! motile cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000473 ! defensive cell @@ -836,6 +1151,13 @@ relationship: RO:0002215 GO:0006909 ! capable of phagocytosis [Term] id: CL:0000235 name: macrophage +def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:16213494, PMID:1919437] +comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. +xref: BTO:0000801 +xref: CALOHA:TS-0587 +xref: FMA:63261 +xref: FMA:83585 +xref: MESH:D008264 is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000766 ! myeloid leukocyte @@ -845,11 +1167,12 @@ intersection_of: RO:0002215 GO:0006909 ! capable of phagocytosis intersection_of: RO:0002215 GO:0031268 ! capable of pseudopodium organization relationship: RO:0002202 CL:0000576 ! monocyte relationship: RO:0002215 GO:0031268 ! capable of pseudopodium organization -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000255 name: eukaryotic cell +def: "Any cell that only exists in Eukaryota." [FBC:Autogenerated] +xref: MESH:D005057 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002160 NCBITaxon:2759 ! Eukaryota @@ -858,6 +1181,7 @@ relationship: RO:0002160 NCBITaxon:2759 ! Eukaryota [Term] id: CL:0000257 name: Eumycetozoan cell +def: "Any cell that only exists in Eumycetozoa." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002160 NCBITaxon:142796 ! Eumycetozoa @@ -866,20 +1190,24 @@ relationship: RO:0002160 NCBITaxon:142796 ! Eumycetozoa [Term] id: CL:0000287 name: eye photoreceptor cell +def: "Any photoreceptor cell that is part of some eye." [FBC:Autogenerated] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000970 ! part of eye relationship: BFO:0000050 UBERON:0000970 ! part of eye -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000293 name: structural cell +def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr] is_a: CL:0000000 ! cell [Term] id: CL:0000300 name: gamete +def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544] +xref: CALOHA:TS-0395 +xref: FMA:18649 is_a: CL:0000413 ! haploid cell is_a: CL:0000586 ! germ cell intersection_of: CL:0000586 ! germ cell @@ -895,6 +1223,9 @@ is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000307 name: tracheal epithelial cell +def: "An epithelial cell found in the trachea." [GOC:tfm] +comment: This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' +xref: FMA:74793 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea @@ -904,11 +1235,28 @@ relationship: RO:0002202 CL:0000377 ! tracheoblast [Term] id: CL:0000313 name: serous secreting cell +def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] +xref: BTO:0003687 +xref: FMA:62511 +is_a: CL:0000159 ! seromucus secreting cell + +[Term] +id: CL:0000319 +name: mucus secreting cell +def: "Any secretory cell that is capable of some mucus secretion." [FBC:Autogenerated] +xref: BTO:0003689 is_a: CL:0000159 ! seromucus secreting cell +intersection_of: CL:0000151 ! secretory cell +intersection_of: RO:0002215 GO:0070254 ! capable of mucus secretion +relationship: RO:0002215 GO:0070254 ! capable of mucus secretion [Term] id: CL:0000322 name: pulmonary alveolar epithelial cell +def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [GOC:tfm, PMID:20054144, PMID:29463737] +xref: BTO:0000395 +xref: CALOHA:TS-2168 +xref: FMA:62499 is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0010003 ! epithelial cell of alveolus of lung relationship: BFO:0000050 UBERON:0004821 ! part of pulmonary alveolus epithelium @@ -916,6 +1264,7 @@ relationship: BFO:0000050 UBERON:0004821 ! part of pulmonary alveolus epithelium [Term] id: CL:0000325 name: stuff accumulating cell +def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma] is_a: CL:0000000 ! cell [Term] @@ -926,6 +1275,7 @@ is_a: CL:0000499 ! stromal cell [Term] id: CL:0000329 name: oxygen accumulating cell +def: "Any cell that is capable of some oxygen transport." [FBC:Autogenerated] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0015671 ! capable of oxygen transport @@ -934,6 +1284,8 @@ relationship: RO:0002215 GO:0015671 ! capable of oxygen transport [Term] id: CL:0000333 name: migratory neural crest cell +def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [doi:10.1016/j.stem.2015.02.017] +xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0011012 ! neural crest cell is_a: CL:0011026 ! progenitor cell @@ -942,11 +1294,13 @@ relationship: RO:0002202 CL:0007004 ! premigratory neural crest cell [Term] id: CL:0000335 name: mesenchyme condensation cell +def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] is_a: CL:0008019 ! mesenchymal cell [Term] id: CL:0000347 name: scleral cell +def: "A cell of the sclera of the eye." [GOC:add] is_a: BFO:0000002 is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell @@ -957,6 +1311,7 @@ relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000348 name: choroidal cell of the eye +def: "A structural cell that is part of optic choroid." [GOC:add] is_a: BFO:0000002 is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell @@ -967,6 +1322,7 @@ relationship: RO:0002202 CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000349 name: extraembryonic cell +def: "Any cell that is part of some extraembryonic structure." [FBC:Autogenerated] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure @@ -975,40 +1331,63 @@ relationship: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure [Term] id: CL:0000351 name: trophoblast cell +def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:D014327] +xref: FMA:83028 is_a: CL:0000349 ! extraembryonic cell relationship: BFO:0000050 UBERON:0000358 ! part of blastocyst [Term] id: CL:0000352 name: epiblast cell +def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256] is_a: CL:0000052 ! totipotent stem cell [Term] id: CL:0000353 name: blastoderm cell +def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:D001756] +xref: BTO:0001473 +xref: FMA:72551 is_a: CL:0000007 ! early embryonic cell (metazoa) [Term] id: CL:0000355 name: multi-potent skeletal muscle stem cell +def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570] +comment: Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. +xref: FMA:86767 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000188 ! cell of skeletal muscle intersection_of: CL:0000048 ! multi fate stem cell intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue +[Term] +id: CL:0000358 +name: sphincter associated smooth muscle cell +def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm] +is_a: CL:0000192 ! smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: BFO:0000050 UBERON:0004590 ! part of sphincter muscle +relationship: BFO:0000050 UBERON:0004590 ! part of sphincter muscle + [Term] id: CL:0000359 name: vascular associated smooth muscle cell +def: "A smooth muscle cell associated with the vasculature." [GOC:dsd, GOC:tfm] is_a: CL:0000192 ! smooth muscle cell is_a: CL:4033054 ! perivascular cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002049 ! part of vasculature relationship: BFO:0000050 UBERON:0002049 ! part of vasculature -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000362 name: epidermal cell +def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma] +xref: BTO:0001470 +xref: CALOHA:TS-0283 +xref: FMA:62411 +xref: MESH:D000078404 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0007376 ! part of outer epithelium @@ -1017,6 +1396,10 @@ relationship: BFO:0000050 UBERON:0007376 ! part of outer epithelium [Term] id: CL:0000365 name: animal zygote +def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208] +xref: BTO:0000854 +xref: EHDAA2:0004546 +xref: FMA:72395 is_a: CL:0000007 ! early embryonic cell (metazoa) is_a: CL:0000255 ! eukaryotic cell is_a: CL:0010017 ! zygote @@ -1032,11 +1415,13 @@ is_a: CL:0000069 ! branched duct epithelial cell [Term] id: CL:0000393 name: electrically responsive cell +def: "A cell whose function is determined by its response to an electric signal." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000397 name: ganglion interneuron +def: "Any interneuron that has its soma located in some ganglion." [FBC:Autogenerated] is_a: CL:0000099 ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0000045 ! ganglion @@ -1045,25 +1430,42 @@ relationship: RO:0002100 UBERON:0000045 ! ganglion [Term] id: CL:0000402 name: CNS interneuron +def: "An interneuron that has its cell body in a central nervous system." [doi:10.1016/B978-0-12-817424-1.00001-X] +comment: Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system. is_a: CL:0000099 ! interneuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0001017 ! central nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000404 name: electrically signaling cell +def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma] is_a: CL:0000211 ! electrically active cell +[Term] +id: CL:0000412 +name: polyploid cell +def: "A cell that contains more than two haploid sets of chromosomes." [FB:ma, https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy, PMID:32646579] +is_a: CL:0000000 ! cell +intersection_of: CL:0000000 ! cell +intersection_of: RO:0000053 PATO:0001377 ! bearer of +relationship: RO:0000053 PATO:0001377 ! bearer of + [Term] id: CL:0000413 name: haploid cell +def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0001375 ! bearer of relationship: RO:0000053 PATO:0001375 ! bearer of +[Term] +id: CL:0000417 +name: endopolyploid cell +is_a: CL:0000412 ! polyploid cell + [Term] id: CL:0000447 name: carbohydrate secreting cell @@ -1072,6 +1474,11 @@ is_a: CL:0000151 ! secretory cell [Term] id: CL:0000451 name: dendritic cell +def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149] +xref: BTO:0002042 +xref: CALOHA:TS-0194 +xref: FMA:83036 +xref: MESH:D003713 is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000145 ! professional antigen presenting cell intersection_of: CL:0000738 ! leukocyte @@ -1095,7 +1502,6 @@ relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part relationship: RO:0002215 GO:0001816 ! capable of cytokine production relationship: RO:0002215 GO:0045580 ! capable of regulation of T cell differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000457 @@ -1105,6 +1511,7 @@ is_a: CL:0000151 ! secretory cell [Term] id: CL:0000458 name: serotonin secreting cell +def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0001820 ! capable of serotonin secretion @@ -1113,6 +1520,7 @@ relationship: RO:0002215 GO:0001820 ! capable of serotonin secretion [Term] id: CL:0000459 name: noradrenergic cell +def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0048243 ! capable of norepinephrine secretion @@ -1121,11 +1529,13 @@ relationship: RO:0002215 GO:0048243 ! capable of norepinephrine secretion [Term] id: CL:0000473 name: defensive cell +def: "A cell whose primary function is to protect the organism." [JB:jb] is_a: CL:0000000 ! cell [Term] id: CL:0000488 name: visible light photoreceptor cell +def: "A photoreceptor cell that detects visible light." [GOC:tfm] is_a: CL:0000210 ! photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: RO:0002215 GO:0009584 ! capable of detection of visible light @@ -1134,14 +1544,56 @@ relationship: RO:0002215 GO:0009584 ! capable of detection of visible light [Term] id: CL:0000499 name: stromal cell +def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:D017154] +xref: BTO:0002064 +xref: FMA:83624 is_a: BFO:0000002 is_a: CL:0002320 ! connective tissue cell relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0000502 +name: type D enteroendocrine cell +def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:D019864] +xref: FMA:62935 +is_a: CL:0000164 ! enteroendocrine cell +is_a: CL:0000172 ! somatostatin secreting cell + +[Term] +id: CL:0000506 +name: enkephalin secreting cell +def: "An endorphine cell that secretes enkephalin." [GO:tfm] +is_a: CL:0000507 ! endorphin secreting cell + +[Term] +id: CL:0000507 +name: endorphin secreting cell +def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm] +is_a: CL:0000167 ! peptide hormone secreting cell + +[Term] +id: CL:0000508 +name: type G enteroendocrine cell +def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:D019863] +xref: BTO:0004108 +xref: FMA:67609 +is_a: CL:0000164 ! enteroendocrine cell +is_a: CL:0000506 ! enkephalin secreting cell +is_a: CL:0000509 ! gastrin secreting cell +is_a: CL:0002180 ! mucous cell of stomach +relationship: BFO:0000050 UBERON:0004997 ! part of mucosa of pyloric antrum + +[Term] +id: CL:0000509 +name: gastrin secreting cell +def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm] +is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000513 name: cardiac muscle myoblast +def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:D032386] +xref: FMA:84797 is_a: CL:0002494 ! cardiocyte is_a: CL:0010021 ! cardiac myoblast intersection_of: CL:0000056 ! myoblast @@ -1152,6 +1604,8 @@ relationship: BFO:0000050 UBERON:0001133 ! part of cardiac muscle tissue [Term] id: CL:0000514 name: smooth muscle myoblast +def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:D032390] +xref: FMA:84798 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000192 ! smooth muscle cell @@ -1160,6 +1614,8 @@ relationship: RO:0002203 CL:0000192 ! smooth muscle cell [Term] id: CL:0000515 name: skeletal muscle myoblast +def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl] +xref: FMA:84799 is_a: CL:0000056 ! myoblast is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000056 ! myoblast @@ -1170,6 +1626,7 @@ relationship: RO:0002203 CL:0008002 ! skeletal muscle fiber [Term] id: CL:0000518 name: phagocyte (sensu Vertebrata) +def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm] is_a: CL:0000234 ! phagocyte is_a: CL:0000255 ! eukaryotic cell relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -1177,6 +1634,7 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: CL:0000521 name: fungal cell +def: "Any cell that only exists in Fungi." [FBC:Autogenerated] is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002160 NCBITaxon:4751 ! Fungi @@ -1185,36 +1643,53 @@ relationship: RO:0002160 NCBITaxon:4751 ! Fungi [Term] id: CL:0000525 name: syncytiotrophoblast cell +def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] +xref: FMA:83043 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000351 ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: RO:0000053 PATO:0001908 ! bearer of relationship: BFO:0000050 UBERON:0000371 ! part of syncytiotrophoblast -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000526 name: afferent neuron +def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:D009475] +xref: FMA:87653 is_a: CL:0000540 ! neuron -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000527 name: efferent neuron +def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:D009476] is_a: CL:0000540 ! neuron [Term] id: CL:0000540 name: neuron +def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:D009474] +comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. +xref: BTO:0000938 +xref: CALOHA:TS-0683 +xref: FMA:54527 +xref: VHOG:0001483 +xref: WBbt:0003679 is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell +relationship: RO:0002202 CL:0000031 {gci_filler="NCBITaxon:7742", gci_relation="RO:0002162", xref="https://github.com/obophenotype/cell-ontology/issues/757"} ! neuroblast (sensu Vertebrata) relationship: RO:0002215 GO:0019226 ! capable of transmission of nerve impulse -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000542 name: lymphocyte +def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149] +comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) +xref: BTO:0000775 +xref: CALOHA:TS-0583 +xref: FMA:62863 +xref: MESH:D008214 +xref: VHOG:0001535 is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000738 ! leukocyte intersection_of: BFO:0000051 CL:0017500 ! has part neutrophillic cytoplasm @@ -1226,11 +1701,12 @@ relationship: BFO:0000051 CL:0017500 ! has part neutrophillic cytoplasm relationship: BFO:0000051 GO:0000792 ! has part heterochromatin relationship: RO:0000053 PATO:0040072 ! bearer of relationship: RO:0002202 CL:0000051 ! common lymphoid progenitor -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000547 name: proerythroblast +def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, PMID:1638021] +xref: FMA:83518 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell @@ -1270,6 +1746,8 @@ relationship: RO:0002202 CL:0000038 ! erythroid progenitor cell [Term] id: CL:0000549 name: basophilic erythroblast +def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464] +xref: FMA:83505 is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017503 ! has part basophilic cytoplasm @@ -1282,6 +1760,8 @@ relationship: RO:0002104 PR:000001945 [Term] id: CL:0000550 name: polychromatophilic erythroblast +def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464] +xref: FMA:83506 is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017504 ! has part polychromatophilic cytoplasm @@ -1295,6 +1775,8 @@ relationship: RO:0002202 CL:0000549 ! basophilic erythroblast [Term] id: CL:0000552 name: orthochromatic erythroblast +def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464] +xref: FMA:84646 is_a: CL:0000765 ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: BFO:0000051 CL:0017502 ! has part acidophilic cytoplasm @@ -1306,6 +1788,12 @@ relationship: RO:0002202 CL:0000550 ! polychromatophilic erythroblast [Term] id: CL:0000553 name: megakaryocyte progenitor cell +def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464] +comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. +xref: BTO:0001164 +xref: CALOHA:TS-0610 +xref: FMA:84235 +xref: MESH:D055016 is_a: CL:0000763 ! myeloid cell is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell @@ -1338,20 +1826,25 @@ relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part relationship: RO:0002202 CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: RO:0002215 GO:0007113 ! capable of endomitotic cell cycle relationship: RO:0002215 GO:0030219 ! capable of megakaryocyte differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000556 name: megakaryocyte +def: "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533, PMID:31043076] +comment: Megakaryocytes are reportedly CD181-positive and CD182-positive. +xref: BTO:0000843 +xref: CALOHA:TS-0611 +xref: FMA:83555 is_a: CL:0000763 ! myeloid cell disjoint_from: CL:0000764 ! erythroid lineage cell relationship: RO:0000053 PATO:0001393 ! bearer of relationship: RO:0002202 CL:0000553 ! megakaryocyte progenitor cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000557 name: granulocyte monocyte progenitor cell +def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/CFU-GM, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251, PMID:16647566] +comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. is_a: CL:0000763 ! myeloid cell is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor is_a: CL:0011026 ! progenitor cell @@ -1372,11 +1865,14 @@ relationship: CL:4030045 PR:000007858 ! lacks_part relationship: RO:0002104 PR:000001865 relationship: RO:0002215 GO:0030225 ! capable of macrophage differentiation relationship: RO:0002215 GO:0030851 ! capable of granulocyte differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000558 name: reticulocyte +def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622] +xref: BTO:0001173 +xref: CALOHA:TS-0864 +xref: MESH:D012156 is_a: CL:0000764 ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part @@ -1410,6 +1906,10 @@ relationship: RO:0002215 GO:0071971 ! capable of extracellular exosome assembly [Term] id: CL:0000559 name: promonocyte +def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [GOC:tfm, ISBN:0721601464] +comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. +xref: BTO:0004657 +xref: FMA:83551 is_a: CL:0000763 ! myeloid cell is_a: CL:0002194 ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell @@ -1419,11 +1919,11 @@ intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: BFO:0000051 GO:0042582 ! has part azurophil granule relationship: RO:0002104 PR:000001012 relationship: RO:0002202 CL:0000040 ! monoblast -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000562 name: nucleate erythrocyte +def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm] is_a: CL:0000232 ! erythrocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000232 ! erythrocyte @@ -1433,6 +1933,8 @@ relationship: RO:0002202 CL:0002421 ! nucleated reticulocyte [Term] id: CL:0000566 name: angioblastic mesenchymal cell +def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659] +comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000134 ! mesenchymal stem cell @@ -1447,6 +1949,7 @@ relationship: RO:0002202 CL:0000134 ! mesenchymal stem cell [Term] id: CL:0000569 name: cardiac mesenchymal cell +def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864] is_a: CL:0008019 ! mesenchymal cell is_a: CL:2000073 ! migratory cardiac neural crest cell intersection_of: CL:0008019 ! mesenchymal cell @@ -1456,23 +1959,34 @@ relationship: RO:0002203 CL:0002494 ! cardiocyte [Term] id: CL:0000573 name: retinal cone cell +def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:D017949] +xref: BTO:0001036 +xref: CALOHA:TS-0866 +xref: FMA:67748 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: RO:0002202 CL:0002672 ! retinal progenitor cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000575 name: corneal epithelial cell +def: "An epithelial cell of the cornea." [GOC:tfm] +xref: BTO:0004298 +xref: CALOHA:TS-0173 +xref: FMA:70551 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0001772 ! part of corneal epithelium relationship: BFO:0000050 UBERON:0001772 ! part of corneal epithelium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000576 name: monocyte +def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:D009000] +comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. +xref: BTO:0000876 +xref: CALOHA:TS-0638 +xref: FMA:62864 is_a: CL:0000113 ! mononuclear phagocyte is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0011026 ! progenitor cell @@ -1485,11 +1999,16 @@ relationship: RO:0002202 CL:0000559 ! promonocyte relationship: RO:0002215 GO:0030225 ! capable of macrophage differentiation relationship: RO:0002215 GO:0030316 ! capable of osteoclast differentiation relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000583 name: alveolar macrophage +def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [GO_REF:0000031, GOC:ana, GOC:dsd, GOC:tfm, MESH:D016676] +comment: A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8. {xref="https://doi.org/10.5281/zenodo.11165918"} +comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. +xref: BTO:0000802 +xref: CALOHA:TS-0030 +xref: FMA:83023 is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:1001603 ! lung macrophage intersection_of: CL:0000864 ! tissue-resident macrophage @@ -1511,18 +2030,24 @@ relationship: RO:0002104 PR:000001813 relationship: RO:0002104 PR:000001931 relationship: RO:0002104 PR:000002064 relationship: RO:0002104 PR:000002972 +relationship: RO:0015004 CL:4037003 ! has characterizing marker set NS forest marker set of alveolar macrophage (Human Lung). relationship: RO:0015016 PR:000001012 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000586 name: germ cell +def: "The reproductive cell in multicellular organisms." [MESH:D005854] +xref: BTO:0000535 +xref: NCIT:C12597 +xref: VHOG:0001534 +xref: WBbt:0006796 is_a: CL:0000039 ! germ line cell relationship: RO:0002216 GO:0009566 ! capable of part of fertilization [Term] id: CL:0000593 name: androgen secreting cell +def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm] is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035935 ! capable of androgen secretion @@ -1531,32 +2056,62 @@ relationship: RO:0002215 GO:0035935 ! capable of androgen secretion [Term] id: CL:0000604 name: retinal rod cell +def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:D017948] +xref: BTO:0001024 +xref: CALOHA:TS-0870 +xref: FMA:67747 is_a: CL:0010009 ! camera-type eye photoreceptor cell relationship: RO:0002202 CL:0002672 ! retinal progenitor cell -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0000622 +name: acinar cell +def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de] +xref: FMA:83625 +xref: MESH:D061354 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0000154 ! protein secreting cell +relationship: BFO:0000050 UBERON:0009842 ! part of glandular acinus [Term] id: CL:0000630 name: supporting cell +def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm] +xref: BTO:0002315 is_a: CL:0000000 ! cell +[Term] +id: CL:0000666 +name: fenestrated endothelial cell +def: "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues." [DOI:10.1007/978-3-211-99390-3_133] +is_a: CL:0000115 ! endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: RO:0000053 PATO:0002064 ! bearer of +relationship: RO:0000053 PATO:0002064 ! bearer of + [Term] id: CL:0000667 name: collagen secreting cell +def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000669 name: pericyte +def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." [GOC:dsd, GOC:tfm, ISBN:0721662544, MESH:D020286, PMID:16807374, PMID:17986482, PMID:20024907] +comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A. +xref: BTO:0002441 +xref: FMA:63174 is_a: CL:0000183 ! contractile cell is_a: CL:0000630 ! supporting cell is_a: CL:0002320 ! connective tissue cell is_a: CL:0008034 ! mural cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000670 name: primordial germ cell +def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289] +xref: FMA:70567 is_a: CL:0000039 ! germ line cell is_a: CL:0000219 ! motile cell intersection_of: CL:0000039 ! germ line cell @@ -1567,12 +2122,14 @@ relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: CL:0000675 name: female gamete +def: "A mature sexual reproductive cell of the female germline." [GOC:tfm] is_a: CL:0000021 ! female germ cell is_a: CL:0000300 ! gamete [Term] id: CL:0000680 name: muscle precursor cell +def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add] is_a: BFO:0000002 is_a: CL:0000055 ! non-terminally differentiated cell intersection_of: CL:0011115 ! precursor cell @@ -1583,12 +2140,19 @@ relationship: RO:0002203 CL:0000187 ! muscle cell [Term] id: CL:0000696 name: PP cell +def: "A cell that stores and secretes pancreatic polypeptide hormone." [GOC:tfm, JB:jb, PMID:15153415] +xref: FMA:62938 +xref: FMA:83409 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000710 name: neurecto-epithelial cell +def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm] +comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). +xref: BTO:0004301 +xref: FMA:70557 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell intersection_of: CL:0002077 ! ecto-epithelial cell @@ -1598,6 +2162,9 @@ relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0000723 name: somatic stem cell +def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103] +xref: CALOHA:TS-2086 +xref: MESH:D053687 is_a: CL:0000034 ! stem cell intersection_of: CL:0000034 ! stem cell intersection_of: RO:0002215 GO:0048103 ! capable of somatic stem cell division @@ -1606,6 +2173,10 @@ relationship: RO:0002215 GO:0048103 ! capable of somatic stem cell division [Term] id: CL:0000737 name: striated muscle cell +def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544] +xref: BTO:0002916 +xref: CALOHA:TS-2157 +xref: FMA:86936 is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000051 GO:0030017 ! has part sarcomere @@ -1617,6 +2188,12 @@ relationship: RO:0000053 PATO:0001410 ! bearer of [Term] id: CL:0000738 name: leukocyte +def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0] +xref: BTO:0000751 +xref: CALOHA:TS-0549 +xref: FMA:62852 +xref: MESH:D007962 +xref: NCIT:C12529 is_a: BFO:0000002 is_a: CL:0000219 ! motile cell is_a: CL:0000255 ! eukaryotic cell @@ -1629,18 +2206,26 @@ relationship: BFO:0000050 UBERON:0002405 ! part of immune system relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002202 CL:0000037 ! hematopoietic stem cell relationship: RO:0002215 GO:0001667 ! capable of ameboidal-type cell migration -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000740 name: retinal ganglion cell +def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph] +xref: BTO:0001800 +xref: FMA:67765 +xref: MESH:D012165 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) relationship: RO:0002100 UBERON:0000966 ! retina -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000746 name: cardiac muscle cell +def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263] +comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. +xref: BTO:0001539 +xref: CALOHA:TS-0115 +xref: FMA:14067 +xref: MESH:D032383 is_a: CL:0000737 ! striated muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000187 ! muscle cell @@ -1651,11 +2236,14 @@ intersection_of: RO:0000056 GO:0060047 ! participates in heart contraction relationship: RO:0000053 PATO:0002478 ! bearer of relationship: RO:0000056 GO:0060047 ! participates in heart contraction relationship: RO:0002202 CL:0000513 ! cardiac muscle myoblast -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000763 name: myeloid cell +def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add] +xref: BTO:0001441 +xref: CALOHA:TS-0647 +xref: MESH:D022423 is_a: BFO:0000002 is_a: CL:0000988 ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell @@ -1665,12 +2253,21 @@ relationship: RO:0002202 CL:0000049 ! common myeloid progenitor [Term] id: CL:0000764 name: erythroid lineage cell +def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm] +comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. +xref: CALOHA:TS-0290 +xref: FMA:62845 +xref: FMA:83516 is_a: CL:0000763 ! myeloid cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000765 name: erythroblast +def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176] +xref: BTO:0001571 +xref: CALOHA:TS-0289 +xref: FMA:83504 +xref: MESH:D004900 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000764 ! erythroid lineage cell @@ -1707,6 +2304,7 @@ relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation [Term] id: CL:0000766 name: myeloid leukocyte +def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add] is_a: CL:0000738 ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte @@ -1715,6 +2313,8 @@ intersection_of: RO:0002202 CL:0000049 ! common myeloid progenitor [Term] id: CL:0000778 name: mononuclear osteoclast +def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452] +comment: Morphology: mononuclear, highly vesicular. is_a: CL:0000092 ! osteoclast is_a: CL:0000113 ! mononuclear phagocyte intersection_of: CL:0000092 ! osteoclast @@ -1723,6 +2323,8 @@ intersection_of: RO:0000053 PATO:0001407 ! bearer of [Term] id: CL:0000779 name: multinuclear osteoclast +def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:9415452] +comment: Morphology: multinucleated, highly vesicular. is_a: CL:0000092 ! osteoclast is_a: CL:0000783 ! multinucleated phagocyte intersection_of: CL:0000092 ! osteoclast @@ -1732,6 +2334,9 @@ relationship: RO:0002202 CL:0000778 ! mononuclear osteoclast [Term] id: CL:0000782 name: myeloid dendritic cell +def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319] +comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). +xref: BTO:0004721 is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell @@ -1743,6 +2348,7 @@ relationship: RO:0002202 CL:0000763 ! myeloid cell [Term] id: CL:0000783 name: multinucleated phagocyte +def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) @@ -1751,6 +2357,7 @@ intersection_of: RO:0000053 PATO:0001908 ! bearer of [Term] id: CL:0000827 name: pro-T cell +def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149] is_a: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030217 ! capable of T cell differentiation @@ -1760,6 +2367,9 @@ relationship: RO:0002215 GO:0030217 ! capable of T cell differentiation [Term] id: CL:0000835 name: myeloblast +def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [GOC:add, http://en.wikipedia.org/wiki/Myeloblast, http://www.cap.org, ISBN:0721601464] +xref: BTO:0000187 +xref: FMA:83524 is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell @@ -1776,6 +2386,10 @@ relationship: RO:0002202 CL:0000557 ! granulocyte monocyte progenitor cell [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell +def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770] +comment: Markers differ between mouse and human. +xref: BTO:0000725 +xref: CALOHA:TS-0448 is_a: BFO:0000002 is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell @@ -1811,11 +2425,15 @@ relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part relationship: RO:0000053 PATO:0001402 ! bearer of relationship: RO:0002104 PR:000001003 relationship: RO:0002202 CL:0000037 ! hematopoietic stem cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000838 name: lymphoid lineage restricted progenitor cell +def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm] +comment: Note that this is a class of cell types, not an identified single cell type. +xref: BTO:0004731 +xref: CALOHA:TS-2025 +xref: FMA:70338 is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell @@ -1826,16 +2444,24 @@ relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell +def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770] +comment: Note that this is a class of cell types, not an identified single cell type. +xref: BTO:0004730 +xref: CALOHA:TS-2099 +xref: FMA:70339 is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030099 ! capable of myeloid cell differentiation relationship: RO:0002215 GO:0030099 ! capable of myeloid cell differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000842 name: mononuclear cell +def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] +xref: BTO:0000878 +xref: CALOHA:TS-0768 +xref: FMA:86713 is_a: CL:0000226 ! single nucleate cell is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte @@ -1844,6 +2470,8 @@ intersection_of: RO:0000053 PATO:0001407 ! bearer of [Term] id: CL:0000860 name: classical monocyte +def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes." [GO_REF:0000031, GOC:add, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] +comment: Markers: CCR2+CXCCR1 (human, mouse, rat). is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part @@ -1859,11 +2487,14 @@ relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part relationship: RO:0002215 GO:0002548 ! capable of monocyte chemotaxis relationship: RO:0002215 GO:0006954 ! capable of inflammatory response relationship: RO:0015015 PR:000001199 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000861 name: elicited macrophage +def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [GO_REF:0000031, GOC:add, GOC:ana, GOC:tfm, PMID:15771589] +comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). +xref: FMA:84643 +xref: FMA:84645 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: RO:0000056 GO:0006954 ! participates in inflammatory response @@ -1879,6 +2510,8 @@ relationship: RO:0002202 CL:0000860 ! classical monocyte [Term] id: CL:0000862 name: suppressor macrophage +def: "A macrophage that suppresses immune responses." [GOC:add, GOC:tfm, PMID:20402419] +comment: Markers: May express: IL10, TGFbeta. is_a: CL:0000861 ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: RO:0002215 GO:0050777 ! capable of negative regulation of immune response @@ -1887,6 +2520,9 @@ relationship: RO:0002215 GO:0050777 ! capable of negative regulation of immune r [Term] id: CL:0000864 name: tissue-resident macrophage +def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654] +xref: FMA:84642 +xref: FMA:84644 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0000479 ! part of tissue @@ -1895,6 +2531,7 @@ relationship: BFO:0000050 UBERON:0000479 ! part of tissue [Term] id: CL:0000878 name: central nervous system macrophage +def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, PMID:16322748] is_a: CL:0000864 ! tissue-resident macrophage is_a: CL:0002319 ! neural cell intersection_of: CL:0000864 ! tissue-resident macrophage @@ -1904,6 +2541,8 @@ relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system [Term] id: CL:0000936 name: early lymphoid progenitor +def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:19022770] +comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell @@ -1919,25 +2558,32 @@ relationship: RO:0002104 PR:000002065 relationship: RO:0002104 PR:000002979 relationship: RO:0002202 CL:0002035 ! Slamf1-negative multipotent progenitor cell relationship: RO:0002215 GO:0030098 ! capable of lymphocyte differentiation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000988 name: hematopoietic cell +def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add] +xref: BTO:0000574 +xref: CALOHA:TS-2017 +xref: FMA:70366 +xref: FMA:83598 is_a: CL:0000000 ! cell [Term] id: CL:0000990 name: conventional dendritic cell +def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [GO_REF:0000031, GOC:amm, PMID:17850486] +comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. +xref: FMA:84191 is_a: CL:0000451 ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: RO:0015015 PR:000001013 relationship: RO:0015015 PR:000001013 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0000995 name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor +comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor @@ -1945,6 +2591,8 @@ union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0001008 name: Kit and Sca1-positive hematopoietic stem cell +def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:17952047, PMID:19022770] +comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617). is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: CL:4030046 PR:000001014 ! lacks_plasma_membrane_part @@ -1971,6 +2619,7 @@ relationship: RO:0002104 PR:000002979 [Term] id: CL:0001012 name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor +comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0000557 ! granulocyte monocyte progenitor cell union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell @@ -1978,6 +2627,7 @@ union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001019 name: CD115-positive monocyte OR common dendritic progenitor +comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell union_of: CL:0001022 ! CD115-positive monocyte union_of: CL:0001029 ! common dendritic progenitor @@ -1985,6 +2635,8 @@ union_of: CL:0001029 ! common dendritic progenitor [Term] id: CL:0001021 name: CD34-positive, CD38-positive common lymphoid progenitor +def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMCID:PMC2346585, PMID:19022770] +comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617). is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor @@ -2002,6 +2654,8 @@ relationship: RO:0002202 CL:0002043 ! CD34-positive, CD38-negative multipotent p [Term] id: CL:0001022 name: CD115-positive monocyte +def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047] +comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). is_a: CL:0000576 ! monocyte is_a: CL:0000839 ! myeloid lineage restricted progenitor cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor @@ -2015,6 +2669,8 @@ relationship: RO:0002202 CL:0002001 ! CD34-positive, CD38-positive granulocyte m [Term] id: CL:0001023 name: Kit-positive, CD34-positive common myeloid progenitor +def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:1261582, PMID:17952047] +comment: Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617). is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive @@ -2034,6 +2690,9 @@ relationship: RO:0015016 PR:000001481 [Term] id: CL:0001024 name: CD34-positive, CD38-negative hematopoietic stem cell +def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:10430905, PMID:11750107, PMID:16551251, PMID:20024907, PMID:9389721] +comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617). +xref: CALOHA:TS-0448 is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part @@ -2057,6 +2716,8 @@ relationship: RO:0002104 PR:000001843 [Term] id: CL:0001025 name: Kit-positive, Sca1-positive common lymphoid progenitor +def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17952047] +comment: Markers are associated with mouse cells. is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor @@ -2079,6 +2740,8 @@ relationship: RO:0015016 PR:000002979 [Term] id: CL:0001026 name: CD34-positive, CD38-positive common myeloid progenitor +def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [GO_REF:0000031, GOC:add, GOC:amm, PMCID:PMC2626675, PMID:16551251] +comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617). is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor is_a: CL:0001059 ! common myeloid progenitor, CD34-positive intersection_of: CL:0001059 ! common myeloid progenitor, CD34-positive @@ -2099,6 +2762,8 @@ relationship: RO:0015016 PR:000001865 [Term] id: CL:0001027 name: CD7-negative lymphoid progenitor cell +def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251] +comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617). is_a: CL:0000051 ! common lymphoid progenitor is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor intersection_of: CL:0000051 ! common lymphoid progenitor @@ -2113,6 +2778,8 @@ relationship: RO:0002202 CL:0001021 ! CD34-positive, CD38-positive common lympho [Term] id: CL:0001028 name: CD7-positive lymphoid progenitor cell +def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395] +comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). is_a: CL:0000051 ! common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part @@ -2126,6 +2793,8 @@ relationship: RO:0002202 CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001029 name: common dendritic progenitor +def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519] +comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). is_a: CL:0000763 ! myeloid cell is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell @@ -2164,6 +2833,7 @@ relationship: RO:0015016 PR:000002065 [Term] id: CL:0001030 name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor +comment: Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617). is_a: CL:0001060 ! hematopoietic oligopotent progenitor cell, lineage-negative union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor @@ -2171,15 +2841,17 @@ union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor [Term] id: CL:0001035 name: bone cell +def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element relationship: BFO:0000050 UBERON:0001474 ! part of bone element -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001054 name: CD14-positive monocyte +def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20." [GOC:add, PMID:22343568] +comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. is_a: CL:0000576 ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part @@ -2190,11 +2862,12 @@ relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part relationship: RO:0002104 PR:000001889 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0001059 name: common myeloid progenitor, CD34-positive +def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566] +comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. is_a: CL:0000049 ! common myeloid progenitor is_a: CL:0011026 ! progenitor cell intersection_of: CL:0000049 ! common myeloid progenitor @@ -2215,6 +2888,7 @@ relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differen [Term] id: CL:0001060 name: hematopoietic oligopotent progenitor cell, lineage-negative +def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part @@ -2246,6 +2920,8 @@ relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part [Term] id: CL:0001066 name: erythroid progenitor cell, mammalian +def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] +xref: BTO:0004911 is_a: CL:0000038 ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part @@ -2278,6 +2954,8 @@ relationship: RO:0002215 GO:0030218 ! capable of erythrocyte differentiation [Term] id: CL:0002000 name: Kit-positive erythroid progenitor cell +def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19805084] +comment: Markers found on mouse cells. is_a: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:4030046 GO:0033001 ! lacks_plasma_membrane_part Fc-gamma receptor III complex @@ -2301,6 +2979,8 @@ relationship: RO:0002202 CL:0002006 ! Kit-positive, CD34-negative megakaryocyte [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor +def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770] +comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. is_a: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: RO:0002104 PR:000001003 @@ -2313,6 +2993,8 @@ relationship: RO:0002202 CL:0001026 ! CD34-positive, CD38-positive common myeloi [Term] id: CL:0002002 name: Kit-positive granulocyte monocyte progenitor +def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:16322423, PMID:19022770, PMID:19273628] +comment: Markers are found on mouse cells. is_a: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: CL:4030046 PR:000001206 ! lacks_plasma_membrane_part @@ -2336,6 +3018,9 @@ relationship: RO:0015015 PR:000001479 [Term] id: CL:0002003 name: CD34-positive, GlyA-negative erythroid progenitor cell +def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] +comment: Cell markers associated with human cells. +xref: FMA:83517 is_a: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:0001066 ! erythroid progenitor cell, mammalian intersection_of: CL:4030046 PR:000001460 ! lacks_plasma_membrane_part @@ -2347,6 +3032,8 @@ relationship: RO:0002202 CL:0002005 ! CD34-positive, CD38-positive megakaryocyte [Term] id: CL:0002004 name: CD34-negative, GlyA-negative proerythroblast +def: "A proerythoblast that is CD34-negative and GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] +comment: Cell surface markers are associated with human cells. is_a: CL:0000547 ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part @@ -2358,6 +3045,8 @@ relationship: RO:0002202 CL:0002003 ! CD34-positive, GlyA-negative erythroid pro [Term] id: CL:0002005 name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell +def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700] +comment: Markers are associated with human cell type. is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part @@ -2372,6 +3061,8 @@ relationship: RO:0002104 PR:000001408 [Term] id: CL:0002006 name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell +def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:19022770] +comment: Markers are associated with mouse cells. is_a: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part @@ -2392,6 +3083,7 @@ relationship: RO:0015016 GO:0033001 ! Fc-gamma receptor III complex [Term] id: CL:0002009 name: macrophage dendritic cell progenitor +def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [GOC:tfm, PMID:19273628] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell is_a: CL:0011026 ! progenitor cell @@ -2405,6 +3097,7 @@ relationship: RO:0002215 GO:0043011 ! capable of myeloid dendritic cell differen [Term] id: CL:0002010 name: pre-conventional dendritic cell +def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [GOC:tfm] is_a: CL:0000763 ! myeloid cell is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell @@ -2445,6 +3138,8 @@ relationship: RO:0002202 CL:0001029 ! common dendritic progenitor [Term] id: CL:0002011 name: Kit-positive macrophage dendritic cell progenitor +def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [GOC:tfm, PMID:19273628] +comment: Markers are associated with mouse cells. is_a: CL:0002009 ! macrophage dendritic cell progenitor intersection_of: CL:0002009 ! macrophage dendritic cell progenitor intersection_of: RO:0002104 PR:000001206 @@ -2460,6 +3155,8 @@ relationship: RO:0015015 PR:000002065 [Term] id: CL:0002012 name: Kit-low proerythroblast +def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [GOC:ak, GOC:tfm, PMID:19805084] +comment: Markers are associated with mouse cells. is_a: CL:0000547 ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part @@ -2477,6 +3174,8 @@ relationship: RO:0015016 PR:000002065 [Term] id: CL:0002013 name: GlyA-positive basophilic erythroblast +def: "A basophilic erythroblast that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] +comment: Markers are associated with human cells. is_a: CL:0000549 ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part @@ -2488,6 +3187,8 @@ relationship: RO:0002202 CL:0002004 ! CD34-negative, GlyA-negative proerythrobla [Term] id: CL:0002014 name: Kit-negative, Ly-76 high basophilic erythroblast +def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] +comment: Cell surface markers are associated with mouse cells. is_a: CL:0000549 ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part @@ -2503,6 +3204,7 @@ relationship: RO:0015015 PR:000002981 [Term] id: CL:0002015 name: Kit-negative, Ly-76 high polychromatophilic erythroblast +def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] is_a: CL:0000550 ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part @@ -2518,6 +3220,8 @@ relationship: RO:0015015 PR:000002981 [Term] id: CL:0002016 name: CD71-low, GlyA-positive polychromatic erythroblast +def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." [GOC:ak, GOC:tfm, PMID:1638021] +comment: Cell surface markers are associated with human cells. is_a: CL:0000550 ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: RO:0002104 PR:000001460 @@ -2529,6 +3233,8 @@ relationship: RO:0015016 PR:000001945 [Term] id: CL:0002017 name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts +def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] +comment: Cell surface markers associated with mouse cells. is_a: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part @@ -2546,6 +3252,8 @@ relationship: RO:0015016 PR:000001945 [Term] id: CL:0002018 name: CD71-negative, GlyA-positive orthochromatic erythroblast +def: "An erythroblast that is GlyA-positive and CD71-negative." [GOC:ak, GOC:tfm, PMID:1638021] +comment: Markers associated with human cells. is_a: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part @@ -2557,6 +3265,7 @@ relationship: RO:0002202 CL:0002016 ! CD71-low, GlyA-positive polychromatic eryt [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell +def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] is_a: BFO:0000002 is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell @@ -2568,6 +3277,8 @@ relationship: RO:0002202 CL:0002032 ! hematopoietic oligopotent progenitor cell [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell +def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770] +comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). is_a: BFO:0000002 is_a: CL:0008001 ! hematopoietic precursor cell intersection_of: CL:0000988 ! hematopoietic cell @@ -2578,6 +3289,8 @@ relationship: RO:0002202 CL:0000837 ! hematopoietic multipotent progenitor cell [Term] id: CL:0002033 name: short term hematopoietic stem cell +def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [GOC:tfm, PMID:15572596, PMID:19022770] +comment: Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low. is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:4030046 PR:000002001 ! lacks_plasma_membrane_part @@ -2590,6 +3303,8 @@ relationship: RO:0002202 CL:0002034 ! long term hematopoietic stem cell [Term] id: CL:0002034 name: long term hematopoietic stem cell +def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [GOC:tfm, PMID:15572596, PMID:17582345] +comment: Markers are associated with mouse cells. is_a: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part @@ -2603,6 +3318,8 @@ relationship: RO:0015016 PR:000001843 [Term] id: CL:0002035 name: Slamf1-negative multipotent progenitor cell +def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [GOC:tfm, PMID:19022770] +comment: Markers are associated with mouse cells. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:4030046 PR:000001833 ! lacks_plasma_membrane_part @@ -2618,6 +3335,8 @@ relationship: RO:0002202 CL:0002036 ! Slamf1-positive multipotent progenitor cel [Term] id: CL:0002036 name: Slamf1-positive multipotent progenitor cell +def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [GOC:tfm, PMID:19022770] +comment: Markers are associated with mouse cells. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: RO:0002104 PR:000001833 @@ -2632,6 +3351,8 @@ relationship: RO:0002202 CL:0002033 ! short term hematopoietic stem cell [Term] id: CL:0002043 name: CD34-positive, CD38-negative multipotent progenitor cell +def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [GOC:tfm, PMID:18371405, PMID:19022770] +comment: Cell markers are associated with human hematopoietic multipotent progenitor cells. is_a: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: CL:4030046 PR:000001015 ! lacks_plasma_membrane_part @@ -2646,15 +3367,20 @@ relationship: RO:0002202 CL:0001024 ! CD34-positive, CD38-negative hematopoietic [Term] id: CL:0002062 name: pulmonary alveolar type 1 cell +def: "A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." [GOC:tfm, http://www.copewithcytokines.de, PMID:20054144, PMID:29463737] +xref: BTO:0000780 +xref: FMA:62500 is_a: CL:0000322 ! pulmonary alveolar epithelial cell intersection_of: CL:0000322 ! pulmonary alveolar epithelial cell intersection_of: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system relationship: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002063 name: pulmonary alveolar type 2 cell +def: "A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." [GOC:tfm, http://www.copewithcytokines.de, ISBN:0412046911, PMID:36138472, PMID:8540632] +xref: BTO:0000538 +xref: FMA:62501 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0000322 ! pulmonary alveolar epithelial cell is_a: CL:1000272 ! lung secretory cell @@ -2662,11 +3388,26 @@ intersection_of: CL:0000322 ! pulmonary alveolar epithelial cell intersection_of: RO:0002215 GO:0032940 ! capable of secretion by cell intersection_of: RO:0002215 GO:0043129 ! capable of surfactant homeostasis relationship: RO:0002202 CL:4040003 ! fetal pre-type II pulmonary alveolar epithelial cell -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0002064 +name: pancreatic acinar cell +def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells, ISBN:0517223651, PMID:20395539] +xref: BTO:0000028 +xref: CALOHA:TS-0737 +xref: FMA:63032 +is_a: CL:0000622 ! acinar cell +is_a: CL:1001599 ! pancreas exocrine glandular cell +intersection_of: CL:0000622 ! acinar cell +intersection_of: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus +relationship: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus +relationship: BFO:0000051 GO:0042589 ! has part zymogen granule membrane [Term] id: CL:0002067 name: type A enteroendocrine cell +def: "An enteroendocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911] +xref: FMA:62939 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell intersection_of: CL:0000164 ! enteroendocrine cell @@ -2675,28 +3416,39 @@ intersection_of: RO:0002215 GO:0070091 ! capable of glucagon secretion [Term] id: CL:0002068 name: Purkinje myocyte +def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742] +xref: BTO:0001032 +xref: FMA:14146 is_a: CL:0002086 ! specialized cardiac myocyte -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002072 name: nodal myocyte +def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm] +xref: BTO:0004190 +xref: FMA:67101 is_a: CL:0002086 ! specialized cardiac myocyte [Term] id: CL:0002073 name: transitional myocyte +def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm] +xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte [Term] id: CL:0002074 name: myocardial endocrine cell +def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm] +xref: FMA:67111 is_a: CL:0000163 ! endocrine cell is_a: CL:0002086 ! specialized cardiac myocyte [Term] id: CL:0002076 name: endo-epithelial cell +def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm] +xref: FMA:69075 is_a: BFO:0000002 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell @@ -2706,6 +3458,8 @@ relationship: RO:0002202 CL:0000223 ! endodermal cell [Term] id: CL:0002077 name: ecto-epithelial cell +def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm] +xref: FMA:69074 is_a: BFO:0000002 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell @@ -2715,28 +3469,76 @@ relationship: RO:0002202 CL:0000221 ! ectodermal cell [Term] id: CL:0002078 name: meso-epithelial cell +def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm] +xref: FMA:69076 is_a: BFO:0000002 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: RO:0002202 CL:0000222 ! mesodermal cell relationship: RO:0002202 CL:0000222 ! mesodermal cell +[Term] +id: CL:0002079 +name: pancreatic ductal cell +def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223] +xref: FMA:63099 +is_a: CL:0000069 ! branched duct epithelial cell +is_a: CL:1001433 ! epithelial cell of exocrine pancreas +intersection_of: CL:0000083 ! epithelial cell of pancreas +intersection_of: BFO:0000050 UBERON:0001064 ! part of ventral pancreatic duct +intersection_of: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity +relationship: BFO:0000050 UBERON:0001064 ! part of ventral pancreatic duct +relationship: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity + +[Term] +id: CL:0002080 +name: pancreatic centro-acinar cell +def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160] +xref: FMA:62455 +is_a: CL:1001433 ! epithelial cell of exocrine pancreas +intersection_of: CL:0000083 ! epithelial cell of pancreas +intersection_of: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus +intersection_of: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity +relationship: BFO:0000050 UBERON:0001263 ! part of pancreatic acinus +relationship: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity + [Term] id: CL:0002086 name: specialized cardiac myocyte +def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm] +xref: FMA:67968 is_a: CL:0000746 ! cardiac muscle cell [Term] id: CL:0002087 name: nongranular leukocyte +def: "A leukocyte that lacks granules." [GOC:tfm] +xref: FMA:62855 is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: CL:4030045 GO:0030141 ! lacks_part secretory granule relationship: CL:4030045 GO:0030141 ! lacks_part secretory granule +[Term] +id: CL:0002088 +name: interstitial cell of Cajal +def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112] +comment: Some argue this cell type is of mesenchymal origin. +xref: BTO:0003914 +xref: FMA:86573 +is_a: CL:0000710 ! neurecto-epithelial cell +intersection_of: CL:0000710 ! neurecto-epithelial cell +intersection_of: RO:0002215 GO:0043134 ! capable of regulation of hindgut contraction +relationship: RO:0002215 GO:0043134 ! capable of regulation of hindgut contraction + [Term] id: CL:0002092 name: bone marrow cell +def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256] +comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. +xref: BTO:0004850 +xref: FMA:83621 +xref: MESH:D001854 is_a: CL:0001035 ! bone cell intersection_of: CL:0001035 ! bone cell intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow @@ -2745,13 +3547,16 @@ relationship: BFO:0000050 UBERON:0002371 ! part of bone marrow [Term] id: CL:0002095 name: hilus cell of ovary +def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X] +xref: FMA:18710 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002132 ! stromal cell of ovary -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002132 name: stromal cell of ovary +def: "A stomal cell of the ovary" [GOC:tfm] +xref: FMA:72299 is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary @@ -2760,35 +3565,48 @@ relationship: BFO:0000050 UBERON:0000992 ! part of ovary [Term] id: CL:0002139 name: endothelial cell of vascular tree +def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659] +comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. +xref: BTO:0001854 +xref: CALOHA:TS-1106 +xref: FMA:67755 is_a: CL:0000115 ! endothelial cell [Term] id: CL:0002144 name: capillary endothelial cell +def: "An endothelial cell found in capillaries." [GOC:tfm] +xref: BTO:0004956 +xref: CALOHA:TS-0112 +xref: FMA:67756 is_a: CL:0002653 ! squamous endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0001915 ! part of endothelium of capillary relationship: BFO:0000050 UBERON:0001915 ! part of endothelium of capillary -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002145 name: ciliated columnar cell of tracheobronchial tree +def: "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." [GOC:tfm, ISBN:0517223651] +xref: FMA:70542 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0005012 ! multi-ciliated epithelial cell is_a: CL:4030034 ! respiratory ciliated cell relationship: RO:0002202 CL:0002209 ! intermediate epitheliocyte -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002159 name: general ecto-epithelial cell +def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm] +xref: FMA:70556 is_a: CL:0002077 ! ecto-epithelial cell [Term] id: CL:0002178 name: epithelial cell of stomach +def: "An epithelial cell found in the lining of the stomach." [GOC:tfm] +xref: FMA:62948 is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach @@ -2797,6 +3615,8 @@ relationship: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: CL:0002180 name: mucous cell of stomach +def: "A mucous cell in the epithelium of the stomach." [GOC:tfm] +xref: FMA:63464 is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002178 ! epithelial cell of stomach intersection_of: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach @@ -2805,6 +3625,8 @@ relationship: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach [Term] id: CL:0002183 name: stem cell of gastric gland +def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651] +xref: FMA:62953 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000152 ! exocrine cell is_a: CL:0002180 ! mucous cell of stomach @@ -2815,6 +3637,8 @@ relationship: BFO:0000050 UBERON:0000325 ! part of gastric gland [Term] id: CL:0002191 name: granulocytopoietic cell +def: "A cell involved in the formation of a granulocyte." [GOC:tfm] +xref: FMA:83519 is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030851 ! capable of granulocyte differentiation @@ -2823,14 +3647,28 @@ relationship: RO:0002215 GO:0030851 ! capable of granulocyte differentiation [Term] id: CL:0002194 name: monopoietic cell +def: "A cell involved in the formation of a monocyte (monopoiesis)." [GOC:tfm] +xref: FMA:83552 is_a: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030224 ! capable of monocyte differentiation relationship: RO:0002215 GO:0030224 ! capable of monocyte differentiation +[Term] +id: CL:0002195 +name: hepatic stem cell +def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." [GOC:tfm, PMID:26798363] +xref: FMA:86577 +is_a: CL:0000048 ! multi fate stem cell +intersection_of: CL:0000048 ! multi fate stem cell +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: CL:0002202 name: epithelial cell of tracheobronchial tree +def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm] +xref: FMA:66816 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium @@ -2839,11 +3677,15 @@ relationship: BFO:0000050 UBERON:0008397 ! part of tracheobronchial epithelium [Term] id: CL:0002209 name: intermediate epitheliocyte +def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651] +xref: FMA:69060 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree [Term] id: CL:0002222 name: vertebrate lens cell +def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544] +xref: FMA:70950 is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye @@ -2851,16 +3693,19 @@ relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye [Term] id: CL:0002224 name: lens epithelial cell +def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544] +xref: FMA:67559 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002222 ! vertebrate lens cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: BFO:0000050 UBERON:0001803 ! part of epithelium of lens relationship: BFO:0000050 UBERON:0001803 ! part of epithelium of lens -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002240 name: marrow fibroblast +def: "A fibroblast in the bone marrow." [GOC:tfm] +xref: FMA:84377 is_a: CL:0000057 ! fibroblast is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000057 ! fibroblast @@ -2869,6 +3714,8 @@ intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow [Term] id: CL:0002241 name: pulmonary interstitial fibroblast +def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm] +xref: FMA:84467 is_a: CL:0000057 ! fibroblast is_a: CL:4030031 ! interstitial cell intersection_of: CL:0000057 ! fibroblast @@ -2879,14 +3726,31 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: CL:0002242 name: nucleate cell +def: "A cell containing at least one nucleus." [GOC:tfm] +xref: FMA:67513 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0000053 PATO:0002505 ! bearer of relationship: RO:0000053 PATO:0002505 ! bearer of +[Term] +id: CL:0002243 +name: smooth muscle cell of sphincter of pupil +def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128] +xref: FMA:70611 +is_a: CL:0000358 ! sphincter associated smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: BFO:0000050 UBERON:0001607 ! part of sphincter pupillae +relationship: BFO:0000050 UBERON:0001607 ! part of sphincter pupillae +relationship: RO:0002202 CL:0000133 ! neurectodermal cell + [Term] id: CL:0002246 name: peripheral blood stem cell +def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm] +xref: BTO:0002669 +xref: FMA:86711 +xref: MESH:D000072916 is_a: CL:0000037 ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell intersection_of: CL:0000037 ! hematopoietic stem cell @@ -2896,6 +3760,7 @@ relationship: BFO:0000050 UBERON:0000178 ! part of blood [Term] id: CL:0002251 name: epithelial cell of alimentary canal +def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract @@ -2904,31 +3769,104 @@ relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: CL:0002252 name: epithelial cell of esophagus +def: "An epithelial cell of the esophagus." [GOC:tfm] +xref: FMA:63071 is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus +[Term] +id: CL:0002253 +name: epithelial cell of large intestine +def: "An epithelial cell of the large intestine." [GOC:tfm] +xref: BTO:0004297 +xref: FMA:256157 +is_a: CL:0002563 ! intestinal epithelial cell +intersection_of: CL:0002563 ! intestinal epithelial cell +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine + +[Term] +id: CL:0002254 +name: epithelial cell of small intestine +def: "An epithelial cell of the small intestine." [GOC:tfm] +xref: FMA:256159 +is_a: CL:0002563 ! intestinal epithelial cell +intersection_of: CL:0002563 ! intestinal epithelial cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0002108 ! part of small intestine + [Term] id: CL:0002262 name: endothelial cell of sinusoid +def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256] +xref: FMA:63134 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0003909 ! part of sinusoid relationship: BFO:0000050 UBERON:0003909 ! part of sinusoid -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002264 name: type A cell of stomach +def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm] +xref: FMA:83411 is_a: CL:0002067 ! type A enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002067 ! type A enteroendocrine cell intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach +[Term] +id: CL:0002265 +name: type D cell of colon +def: "A D cell located in the colon." [GOC:tfm] +xref: FMA:268744 +is_a: CL:0000502 ! type D enteroendocrine cell +is_a: CL:0009042 ! enteroendocrine cell of colon +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:0002266 +name: type D cell of small intestine +def: "A type D cell of the small intestine." [GOC:tfm] +xref: FMA:268736 +is_a: CL:0000502 ! type D enteroendocrine cell +is_a: CL:0009006 ! enteroendocrine cell of small intestine +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: CL:0002267 +name: type D cell of stomach +def: "A type D cell found in the stomach." [GOC:tfm] +xref: FMA:83410 +is_a: CL:0000502 ! type D enteroendocrine cell +is_a: CL:0002659 ! glandular cell of stomach +intersection_of: CL:0000502 ! type D enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach + +[Term] +id: CL:0002275 +name: pancreatic PP cell +def: "A PP cell located in the islets of the pancreas." [GOC:tfm] +comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. +xref: BTO:0000805 +xref: FMA:70588 +xref: MESH:D050418 +is_a: CL:0000696 ! PP cell +is_a: CL:0008024 ! pancreatic endocrine cell +intersection_of: CL:0000696 ! PP cell +intersection_of: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0000006 ! part of islet of Langerhans + [Term] id: CL:0002308 name: epithelial cell of skin gland +def: "An epithelial cell of a skin gland." [GOC:tfm] +xref: FMA:70657 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002419 ! part of skin gland @@ -2937,6 +3875,9 @@ relationship: BFO:0000050 UBERON:0002419 ! part of skin gland [Term] id: CL:0002319 name: neural cell +def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] +xref: CALOHA:TS-2040 +xref: FMA:70333 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system @@ -2945,6 +3886,10 @@ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system [Term] id: CL:0002320 name: connective tissue cell +def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256] +xref: CALOHA:TS-2096 +xref: FMA:63875 +xref: MESH:D003239 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue @@ -2953,11 +3898,17 @@ relationship: BFO:0000050 UBERON:0002384 ! part of connective tissue [Term] id: CL:0002321 name: embryonic cell (metazoa) +def: "A cell of the embryo." [FMA:0618947256] +xref: CALOHA:TS-0263 +xref: FMA:82840 +xref: WBbt:0007028 is_a: CL:0000000 ! cell [Term] id: CL:0002328 name: bronchial epithelial cell +def: "An epithelial cell of the bronchus." [GOC:tfm] +xref: BTO:0002922 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus @@ -2966,15 +3917,16 @@ relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus [Term] id: CL:0002332 name: ciliated cell of the bronchus +def: "A ciliated cell of the bronchus." [GOC:tfm, PMID:18757316] is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0000064 ! ciliated cell intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002333 name: neural crest derived adipocyte +def: "An adipocyte derived from a neural crest cell." [GOC:tfm, PMID:17507398] is_a: CL:0000136 ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: RO:0002202 CL:0000333 ! migratory neural crest cell @@ -2984,15 +3936,23 @@ relationship: RO:0002202 CL:0000333 ! migratory neural crest cell [Term] id: CL:0002350 name: endocardial cell +def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458] +xref: FMA:75621 is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0002165 ! part of endocardium relationship: BFO:0000050 UBERON:0002165 ! part of endocardium -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0002351 +name: progenitor cell of endocrine pancreas +def: "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494, PMID:22728667] +is_a: CL:0011026 ! progenitor cell [Term] id: CL:0002352 name: gestational hematopoietic stem cell +def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6] is_a: CL:0000037 ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -3001,15 +3961,17 @@ relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: CL:0002363 name: keratocyte +def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." [GOC:tfm, ISBN:9780702029585] is_a: CL:0000005 ! neural crest derived fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea relationship: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002368 name: respiratory epithelial cell +def: "An endo-epithelial cell of the respiratory tract." [GOC:tfm] +xref: BTO:0004533 is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium @@ -3018,6 +3980,7 @@ relationship: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium [Term] id: CL:0002372 name: myotube +def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000737 ! striated muscle cell intersection_of: CL:0000187 ! muscle cell @@ -3029,6 +3992,8 @@ relationship: RO:0000053 PATO:0002478 ! bearer of [Term] id: CL:0002397 name: CD14-positive, CD16-positive monocyte +def: "A CD14-positive monocyte that is also CD16-positive and CCR2-negative." [GOC:tfm, PMID:20628149, PMID:21937707, PMID:22343568] +comment: This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+). is_a: CL:0001054 ! CD14-positive monocyte intersection_of: CL:0001054 ! CD14-positive monocyte intersection_of: CL:4030046 PR:000001199 ! lacks_plasma_membrane_part @@ -3039,6 +4004,7 @@ relationship: RO:0002104 PR:000001483 [Term] id: CL:0002421 name: nucleated reticulocyte +def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052] is_a: CL:0000558 ! reticulocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000558 ! reticulocyte @@ -3047,6 +4013,7 @@ intersection_of: RO:0000053 PATO:0002505 ! bearer of [Term] id: CL:0002454 name: Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell +def: "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part @@ -3057,6 +4024,7 @@ relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part [Term] id: CL:0002462 name: adipose dendritic cell +def: "A F4/80-negative dendritic cell located in adipose tissue." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000766 ! myeloid leukocyte is_a: CL:0000990 ! conventional dendritic cell is_a: CL:0002320 ! connective tissue cell @@ -3070,6 +4038,7 @@ relationship: RO:0002202 CL:0002010 ! pre-conventional dendritic cell [Term] id: CL:0002463 name: SIRPa-positive adipose dendritic cell +def: "An adipose dendritic cell that is SIRPa-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001968 @@ -3078,6 +4047,7 @@ relationship: RO:0002104 PR:000001968 [Term] id: CL:0002464 name: SIRPa-negative adipose dendritic cell +def: "An adipose dendritic cell that is SIRPa-negative." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: CL:4030046 PR:000001968 ! lacks_plasma_membrane_part @@ -3086,6 +4056,7 @@ relationship: CL:4030046 PR:000001968 ! lacks_plasma_membrane_part [Term] id: CL:0002465 name: CD11b-positive dendritic cell +def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: RO:0002104 PR:000001012 @@ -3094,6 +4065,12 @@ relationship: RO:0002104 PR:000001012 [Term] id: CL:0002494 name: cardiocyte +def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm] +comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. +xref: BTO:0001539 +xref: CALOHA:TS-0115 +xref: FMA:83808 +xref: FMA:84791 is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ @@ -3102,24 +4079,47 @@ relationship: BFO:0000050 UBERON:0007100 ! part of primary circulatory organ [Term] id: CL:0002503 name: adventitial cell +def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm] +xref: BTO:0002441 +xref: FMA:84639 is_a: CL:0000630 ! supporting cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: BFO:0000050 UBERON:0005742 ! part of adventitia relationship: BFO:0000050 UBERON:0005742 ! part of adventitia +[Term] +id: CL:0002504 +name: enteric smooth muscle cell +def: "A smooth muscle cell of the intestine." [GOC:tfm] +is_a: CL:0000192 ! smooth muscle cell +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0000160 ! part of intestine + [Term] id: CL:0002521 name: subcutaneous adipocyte +def: "An adipocyte that is part of subcutaneous adipose tissue." [GOC:tfm] is_a: CL:0000136 ! adipocyte intersection_of: CL:0000136 ! adipocyte intersection_of: BFO:0000050 UBERON:0002190 ! part of subcutaneous adipose tissue relationship: BFO:0000050 UBERON:0002190 ! part of subcutaneous adipose tissue -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0002538 +name: intrahepatic cholangiocyte +def: "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." [GOC:tfm, PMID:23720296] +is_a: CL:1000488 ! cholangiocyte +intersection_of: CL:1000488 ! cholangiocyte +intersection_of: BFO:0000050 UBERON:0004823 ! part of intrahepatic bile duct epithelium +relationship: BFO:0000050 UBERON:0004823 ! part of intrahepatic bile duct epithelium [Term] id: CL:0002539 name: aortic smooth muscle cell +def: "A smooth muscle cell of the aorta." [GOC:tfm] +xref: BTO:0004577 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0004178 ! part of aorta smooth muscle tissue @@ -3128,6 +4128,7 @@ relationship: BFO:0000050 UBERON:0004178 ! part of aorta smooth muscle tissue [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow +def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm] is_a: CL:0000134 ! mesenchymal stem cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000134 ! mesenchymal stem cell @@ -3136,20 +4137,25 @@ intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow [Term] id: CL:0002543 name: vein endothelial cell +def: "An endothelial cell that is part of the vein." [GOC:tfm] +xref: FMA:62104 +xref: KUPO:0001099 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0001638 ! part of vein relationship: BFO:0000050 UBERON:0001638 ! part of vein -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002546 name: embryonic blood vessel endothelial progenitor cell +def: "An endothelial progenitor cell that participates in angiogenesis during development." [GOC:tfm] +comment: See CL:0002619. is_a: CL:0000222 ! mesodermal cell [Term] id: CL:0002547 name: fibroblast of the aortic adventitia +def: "A fibroblast of the aortic adventitia." [GOC:tfm] is_a: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery intersection_of: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia @@ -3158,6 +4164,7 @@ relationship: BFO:0000050 UBERON:0004664 ! part of aorta tunica adventitia [Term] id: CL:0002548 name: fibroblast of cardiac tissue +def: "A fibroblast that is part of the heart." [GOC:tfm] is_a: CL:0000057 ! fibroblast is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000057 ! fibroblast @@ -3167,6 +4174,7 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: CL:0002551 name: fibroblast of dermis +def: "Any skin fibroblast that is part of some dermis." [FBC:Autogenerated] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis @@ -3175,6 +4183,9 @@ relationship: BFO:0000050 UBERON:0002067 ! part of dermis [Term] id: CL:0002553 name: fibroblast of lung +def: "A fibroblast that is part of lung." [GOC:tfm] +xref: BTO:0000764 +xref: CALOHA:TS-0575 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -3183,23 +4194,62 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: CL:0002557 name: fibroblast of pulmonary artery +def: "A fibroblast of pulmonary artery." [GOC:tfm] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0002563 +name: intestinal epithelial cell +def: "An epithelial cell of the intestine." [GOC:tfm] +is_a: CL:0002251 ! epithelial cell of alimentary canal +intersection_of: CL:0000066 ! epithelial cell +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium [Term] id: CL:0002570 name: mesenchymal stem cell of adipose tissue +def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm] is_a: CL:0000134 ! mesenchymal stem cell intersection_of: CL:0000134 ! mesenchymal stem cell intersection_of: BFO:0000050 UBERON:0001013 ! part of adipose tissue relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue +[Term] +id: CL:0002571 +name: hepatic mesenchymal stem cell +def: "A mesenchymal stem cell of liver." [GOC:tfm] +is_a: CL:0000134 ! mesenchymal stem cell +is_a: CL:0002195 ! hepatic stem cell +intersection_of: CL:0000134 ! mesenchymal stem cell +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver + +[Term] +id: CL:0002572 +name: vertebral mesenchymal stem cell +def: "A mesenchymal stem cell of the vertebrae." [GOC:tfm] +is_a: CL:0000134 ! mesenchymal stem cell +is_a: CL:0001035 ! bone cell +intersection_of: CL:0000134 ! mesenchymal stem cell +intersection_of: BFO:0000050 UBERON:0002412 ! part of vertebra +relationship: BFO:0000050 UBERON:0002412 ! part of vertebra + +[Term] +id: CL:0002574 +name: stromal cell of pancreas +def: "A stromal cell of the pancreas." [GOC:tfm] +is_a: CL:0000499 ! stromal cell +intersection_of: CL:0000499 ! stromal cell +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: CL:0002575 name: central nervous system pericyte +def: "A pericyte of the central nervous system." [GOC:tfm] is_a: CL:0000669 ! pericyte is_a: CL:0002319 ! neural cell intersection_of: CL:0000669 ! pericyte @@ -3209,16 +4259,17 @@ relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system [Term] id: CL:0002585 name: retinal blood vessel endothelial cell +def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm] is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0009004 ! retinal cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0000966 ! part of retina relationship: BFO:0000050 UBERON:0000966 ! part of retina -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002589 name: smooth muscle cell of the brachiocephalic vasculature +def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery @@ -3227,6 +4278,7 @@ relationship: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery [Term] id: CL:0002590 name: smooth muscle cell of the brain vasculature +def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm] is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:0002319 ! neural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell @@ -3236,15 +4288,17 @@ relationship: BFO:0000050 UBERON:0000955 ! part of brain [Term] id: CL:0002591 name: smooth muscle cell of the pulmonary artery +def: "A smooth muscle of the pulmonary artery." [GOC:tfm] +xref: BTO:0003336 is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002595 name: smooth muscle cell of the subclavian artery +def: "A smooth muscle cell of the subclavian artery." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0001533 ! part of subclavian artery @@ -3253,6 +4307,7 @@ relationship: BFO:0000050 UBERON:0001533 ! part of subclavian artery [Term] id: CL:0002596 name: smooth muscle cell of the carotid artery +def: "Smooth muscle cell of the carotid artery." [GOC:tfm] is_a: CL:0019018 ! blood vessel smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: BFO:0000050 UBERON:0005396 ! part of carotid artery segment @@ -3261,15 +4316,17 @@ relationship: BFO:0000050 UBERON:0005396 ! part of carotid artery segment [Term] id: CL:0002598 name: bronchial smooth muscle cell +def: "Any smooth muscle cell that is part of some bronchus." [FBC:Autogenerated] +xref: BTO:0004402 is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002599 name: smooth muscle cell of the esophagus +def: "A smooth muscle cell of the esophagus." [GOC:tfm] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -3278,6 +4335,7 @@ relationship: BFO:0000050 UBERON:0001043 ! part of esophagus [Term] id: CL:0002600 name: smooth muscle cell of trachea +def: "A smooth muscle cell of the trachea." [GOC:tfm] is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea @@ -3286,6 +4344,7 @@ relationship: BFO:0000050 UBERON:0003126 ! part of trachea [Term] id: CL:0002610 name: raphe nuclei neuron +def: "A neuron of the raphe nuclei." [GOC:tfm] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) @@ -3295,6 +4354,7 @@ relationship: RO:0002100 UBERON:0004684 ! raphe nuclei [Term] id: CL:0002612 name: neuron of the ventral spinal cord +def: "A neuron of the ventral spinal cord." [GOC:tfm] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata) @@ -3304,15 +4364,18 @@ relationship: RO:0002100 UBERON:0002257 ! ventral horn of spinal cord [Term] id: CL:0002620 name: skin fibroblast +def: "A fibroblast of skin." [GOC:tfm] +xref: BTO:0001255 +xref: CALOHA:TS-0935 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000050 UBERON:0002097 ! part of skin of body -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0002632 name: epithelial cell of lower respiratory tract +def: "Any epithelial cell that is part of some lower respiratory tract epithelium." [FBC:Autogenerated] is_a: CL:0002368 ! respiratory epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0004815 ! part of lower respiratory tract epithelium @@ -3321,19 +4384,35 @@ relationship: BFO:0000050 UBERON:0004815 ! part of lower respiratory tract epith [Term] id: CL:0002653 name: squamous endothelial cell +def: "A squamous shaped endothelial cell." [GOC:dos] is_a: CL:0000115 ! endothelial cell [Term] id: CL:0002657 name: glandular cell of esophagus +def: "A glandular epithelial cell of the esophagus." [GOC:tfm] +xref: FMA:86548 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus +[Term] +id: CL:0002658 +name: glandular cell of the large intestine +def: "A glandular epithelial cell of the large intestine." [GOC:tfm] +xref: FMA:87194 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0002253 ! epithelial cell of large intestine +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine + [Term] id: CL:0002659 name: glandular cell of stomach +def: "A glandular epithelial cell that is part of the stomach." [GOC:tfm] +xref: CALOHA:TS-1284 +xref: FMA:86554 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002178 ! epithelial cell of stomach intersection_of: CL:0000150 ! glandular epithelial cell @@ -3342,6 +4421,8 @@ intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: CL:0002663 name: myocardial endocrine cell of atrium +def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm] +xref: FMA:83389 is_a: CL:0002074 ! myocardial endocrine cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium @@ -3350,11 +4431,14 @@ relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium [Term] id: CL:0002664 name: cardioblast +def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164] +comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0002672 name: retinal progenitor cell +def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186] is_a: BFO:0000002 is_a: CL:0000048 ! multi fate stem cell relationship: RO:0002202 CL:0000133 ! neurectodermal cell @@ -3362,13 +4446,25 @@ relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0002676 name: neural crest derived neuroblast +def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019] is_a: CL:0000031 ! neuroblast (sensu Vertebrata) is_a: CL:0011026 ! progenitor cell relationship: RO:0002202 CL:0000333 ! migratory neural crest cell +[Term] +id: CL:0002680 +name: PP cell of intestine +def: "A PP cell found in intestine." [GOC:tfm, PMID:2420136, PMID:728970] +is_a: CL:0000696 ! PP cell +is_a: CL:1001516 ! intestinal enteroendocrine cell +intersection_of: CL:0000696 ! PP cell +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine + [Term] id: CL:0005000 name: spinal cord interneuron +def: "A CNS interneuron located in the spinal cord." [CL:CVS] +comment: Is_a interneuron, part_of UBERON:0002240. is_a: CL:0000402 ! CNS interneuron intersection_of: CL:0000099 ! interneuron intersection_of: RO:0002100 UBERON:0002240 ! spinal cord @@ -3377,16 +4473,26 @@ relationship: RO:0002100 UBERON:0002240 ! spinal cord [Term] id: CL:0005012 name: multi-ciliated epithelial cell +def: "A ciliated epithelial cell with many cilia." [CL:CVS] is_a: CL:0000067 ! ciliated epithelial cell +[Term] +id: CL:0005026 +name: hepatoblast +def: "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." [GOC:CVS, https://orcid.org/0000-0003-1940-6740, PMID:18356246, PMID:20483998, PMID:26798363] +is_a: CL:0000048 ! multi fate stem cell + [Term] id: CL:0007001 name: skeletogenic cell +def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034] +comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) is_a: CL:0000000 ! cell [Term] id: CL:0007004 name: premigratory neural crest cell +def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002] is_a: BFO:0000002 is_a: CL:0011012 ! neural crest cell relationship: BFO:0000050 UBERON:0002342 ! part of neural crest @@ -3395,21 +4501,26 @@ relationship: RO:0002202 CL:0000133 ! neurectodermal cell [Term] id: CL:0007009 name: prechondroblast +def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034] is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0008000 name: non-striated muscle cell +def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS] is_a: CL:0000187 ! muscle cell [Term] id: CL:0008001 name: hematopoietic precursor cell +def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos] is_a: CL:0000988 ! hematopoietic cell [Term] id: CL:0008002 name: skeletal muscle fiber +def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908] +xref: MESH:D018485 is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0002372 ! myotube intersection_of: CL:0000187 ! muscle cell @@ -3422,6 +4533,7 @@ relationship: RO:0002202 CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0008007 name: visceral muscle cell +def: "A muscle cell that is part of some visceral muscle." [GOC:dos] is_a: CL:0000187 ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: BFO:0000050 UBERON:8600004 ! part of visceral muscle tissue @@ -3430,6 +4542,7 @@ relationship: BFO:0000050 UBERON:8600004 ! part of visceral muscle tissue [Term] id: CL:0008008 name: striated visceral muscle cell +def: "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods." [GOC:dos] is_a: CL:0000737 ! striated muscle cell is_a: CL:0008007 ! visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell @@ -3438,6 +4551,7 @@ intersection_of: RO:0000053 PATO:0001410 {all_some="true"} ! bearer of [Term] id: CL:0008009 name: transversely striated visceral muscle cell +def: "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods." [GOC:dos] is_a: CL:0008008 ! striated visceral muscle cell intersection_of: CL:0008007 ! visceral muscle cell intersection_of: RO:0000053 PATO:0002478 {all_some="true"} ! bearer of @@ -3446,6 +4560,8 @@ relationship: RO:0000053 PATO:0002478 ! bearer of [Term] id: CL:0008017 name: adult skeletal muscle myoblast +def: "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [PMID:23303905] +comment: The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins. is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:0000515 ! skeletal muscle myoblast intersection_of: CL:0000056 ! myoblast @@ -3459,20 +4575,30 @@ def: "A non-polarised cell precursor cell that is part of some mesenchyme, is as is_a: CL:0000219 ! motile cell relationship: BFO:0000050 UBERON:0003104 ! part of mesenchyme relationship: RO:0002215 GO:0016477 ! capable of cell migration -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0008022 name: endocardial cushion cell +def: "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [PMID:18816864] is_a: CL:0000569 ! cardiac mesenchymal cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000569 ! cardiac mesenchymal cell intersection_of: BFO:0000050 UBERON:0002062 ! part of endocardial cushion relationship: BFO:0000050 UBERON:0002062 ! part of endocardial cushion +[Term] +id: CL:0008024 +name: pancreatic endocrine cell +def: "An endocrine cell that is part of the pancreas." [GOC:dos] +is_a: CL:0000083 ! epithelial cell of pancreas +is_a: CL:0000164 ! enteroendocrine cell +intersection_of: CL:0000163 ! endocrine cell +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: CL:0008028 name: visual system neuron +def: "Any neuron that is capable of part of some visual perception." [FBC:Autogenerated] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002216 GO:0007601 ! capable of part of visual perception @@ -3481,12 +4607,13 @@ relationship: RO:0002216 GO:0007601 ! capable of part of visual perception [Term] id: CL:0008034 name: mural cell +def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." [Wiki:Mural_cell&oldid=930603194] is_a: CL:4033054 ! perivascular cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0008035 name: microcirculation associated smooth muscle cell +def: "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel." [FBC:Autogenerated] is_a: CL:0000359 ! vascular associated smooth muscle cell is_a: CL:0008034 ! mural cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell @@ -3496,6 +4623,7 @@ relationship: BFO:0000050 UBERON:0010523 ! part of microcirculatory vessel [Term] id: CL:0009000 name: sensory neuron of spinal nerve +def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr] is_a: CL:3000004 ! peripheral sensory neuron intersection_of: CL:0000101 ! sensory neuron intersection_of: RO:0002100 UBERON:0001780 ! spinal nerve @@ -3505,33 +4633,200 @@ relationship: RO:0002100 UBERON:0001780 ! spinal nerve id: CL:0009001 name: compound eye retinal cell def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." [] +xref: GOC:pr +xref: PMID:12021768 is_a: CL:0009004 ! retinal cell [Term] id: CL:0009004 name: retinal cell +def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:pr] +xref: PMID:10702418 is_a: CL:0002319 ! neural cell intersection_of: CL:0002319 ! neural cell intersection_of: BFO:0000050 UBERON:0005388 ! part of photoreceptor array relationship: BFO:0000050 UBERON:0005388 ! part of photoreceptor array +[Term] +id: CL:0009006 +name: enteroendocrine cell of small intestine +def: "An enteroendocrine cell that is located in the small intestine." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:1001516 ! intestinal enteroendocrine cell +is_a: CL:1001598 ! small intestine glandular cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: CL:0009018 +name: lymphocyte of large intestine lamina propria +def: "A lymphocyte that resides in the lamina propria of the large intestine." [https://orcid.org/0000-0003-4183-8865] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +is_a: CL:0000542 ! lymphocyte +intersection_of: CL:0000542 ! lymphocyte +intersection_of: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine +relationship: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine + +[Term] +id: CL:0009021 +name: stromal cell of lamina propria of large intestine +def: "A stromal cell found in the lamina propria of the large intestine." [http://orcid.org/0000-0003-4183-8865] +is_a: CL:0000499 ! stromal cell +intersection_of: CL:0000499 ! stromal cell +intersection_of: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine +relationship: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine + +[Term] +id: CL:0009022 +name: stromal cell of lamina propria of small intestine +def: "A stromal cell found in the lamina propria of the small intestine." [http://orcid.org/0000-0003-4183-8865] +is_a: CL:0000499 ! stromal cell +intersection_of: CL:0000499 ! stromal cell +intersection_of: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine +relationship: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine + +[Term] +id: CL:0009024 +name: mesothelial cell of small intestine +def: "A mesothelial cell that is part of the small intestine." [http://orcid.org/0000-0003-4183-8865] +is_a: CL:0000077 ! mesothelial cell +is_a: CL:0002254 ! epithelial cell of small intestine +intersection_of: CL:0000077 ! mesothelial cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: CL:0009025 +name: mesothelial cell of colon +def: "A mesothelial cell that is part of the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] +is_a: CL:0000077 ! mesothelial cell +is_a: CL:0011108 ! colon epithelial cell +intersection_of: CL:0000077 ! mesothelial cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:0009038 +name: colon macrophage +def: "A macrophage that is located in the colon." [http://orcid.org/0000-0003-3440-1876] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +is_a: CL:0000235 ! macrophage +intersection_of: CL:0000235 ! macrophage +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:0009040 +name: stromal cell of lamina propria of colon +def: "A stromal cell found in the lamina propria of the colon." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:0009021 ! stromal cell of lamina propria of large intestine +intersection_of: CL:0000499 ! stromal cell +intersection_of: BFO:0000050 UBERON:0007177 ! part of lamina propria of mucosa of colon +relationship: BFO:0000050 UBERON:0007177 ! part of lamina propria of mucosa of colon + +[Term] +id: CL:0009042 +name: enteroendocrine cell of colon +def: "An enteroendocrine cell that is located in the colon." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:1001516 ! intestinal enteroendocrine cell +is_a: CL:1001588 ! colon glandular cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:0009044 +name: lymphocyte of small intestine lamina propria +def: "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response." [https://orcid.org/0000-0003-4183-8865, PMID:26551552] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +is_a: CL:0000542 ! lymphocyte +intersection_of: CL:0000542 ! lymphocyte +intersection_of: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine +relationship: BFO:0000050 UBERON:0001238 ! part of lamina propria of small intestine + +[Term] +id: CL:0009048 +name: anorectum macrophage +def: "A macrophage that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +is_a: CL:0000235 ! macrophage +intersection_of: CL:0000235 ! macrophage +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: CL:0009051 +name: T cell of anorectum +def: "A T cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. +is_a: CL:0000084 ! T cell +intersection_of: CL:0000084 ! T cell +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: CL:0009052 +name: smooth muscle cell of anorectum +def: "A smooth muscle cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:1000279 ! smooth muscle cell of large intestine +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: CL:0009053 +name: stromal cell of anorectum lamina propria +def: "A stromal cell found in the lamina propria of the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:0009021 ! stromal cell of lamina propria of large intestine +intersection_of: CL:0000499 ! stromal cell +intersection_of: BFO:0000050 UBERON:0011189 ! part of lamina propria of large intestine +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: CL:0009063 +name: enteroendocrine cell of anorectum +def: "An enteroendocrine cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: CL:0002658 ! glandular cell of the large intestine +is_a: CL:1001516 ! intestinal enteroendocrine cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + [Term] id: CL:0009089 name: lung pericyte +def: "A pericyte cell that is part of a lung." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] +xref: EFO:0010669 is_a: CL:0000669 ! pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0009094 +name: endothelial cell of hepatic portal vein +def: "An endothelial cell that is part of a hepatic portal vein." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865, PMID:30348985] +xref: EFO:0010704 +is_a: CL:0002543 ! vein endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: BFO:0000050 UBERON:0001639 ! part of hepatic portal vein +relationship: BFO:0000050 UBERON:0001639 ! part of hepatic portal vein [Term] id: CL:0009097 name: embryonic skeletal muscle fiber +def: "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." [http://orcid.org/0000-0003-2034-601X, PMID:32094117, PMID:7196501] is_a: CL:0008002 ! skeletal muscle fiber intersection_of: CL:0008002 ! skeletal muscle fiber intersection_of: RO:0002491 UBERON:0000068 ! embryo stage relationship: RO:0002491 UBERON:0000068 ! embryo stage +[Term] +id: CL:0009100 +name: hepatic portal fibroblast +def: "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." [https://orcid.org/0000-0001-7655-4833, PMID:20209607, PMID:24814904] +is_a: CL:0000057 ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: BFO:0000050 UBERON:0001279 ! part of portal triad +relationship: BFO:0000050 UBERON:0001279 ! part of portal triad + [Term] id: CL:0010001 name: stromal cell of bone marrow @@ -3545,6 +4840,8 @@ intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow id: CL:0010003 name: epithelial cell of alveolus of lung def: "An epithelial cell that is part_of a alveolus of lung." [] +comment: May be merged with pneumocyte in future +xref: MESH:D056809 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0002299 ! part of alveolus of lung @@ -3562,6 +4859,7 @@ intersection_of: BFO:0000050 UBERON:0002371 ! part of bone marrow [Term] id: CL:0010006 name: cardiac blood vessel endothelial cell +def: "Any blood vessel endothelial cell that is part of some heart." [FBC:Autogenerated] is_a: CL:0000071 ! blood vessel endothelial cell is_a: CL:0010008 ! cardiac endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell @@ -3570,6 +4868,7 @@ intersection_of: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: CL:0010007 name: His-Purkinje system cell +def: "Any cell that is part of some His-Purkinje system." [FBC:Autogenerated] is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system @@ -3578,16 +4877,17 @@ relationship: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system [Term] id: CL:0010008 name: cardiac endothelial cell +def: "Any endothelial cell that is part of some heart." [FBC:Autogenerated] is_a: CL:0000115 ! endothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0010009 name: camera-type eye photoreceptor cell +def: "Any photoreceptor cell that is part of some camera-type eye." [FBC:Autogenerated] is_a: BFO:0000002 is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0009004 ! retinal cell @@ -3599,11 +4899,13 @@ relationship: BFO:0000050 UBERON:0000966 ! part of retina id: CL:0010017 name: zygote def: "A zygote in a plant or an animal." [] +xref: MESH:D015053 is_a: CL:0000000 ! cell [Term] id: CL:0010020 name: cardiac glial cell +def: "Any glial cell that is part of some heart." [FBC:Autogenerated] is_a: CL:0000125 ! glial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000125 ! glial cell @@ -3613,6 +4915,8 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: CL:0010021 name: cardiac myoblast +def: "Any myoblast that develops into some cardiac muscle cell." [FBC:Autogenerated] +xref: MESH:D032386 is_a: CL:0000056 ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: RO:0002203 CL:0000746 ! cardiac muscle cell @@ -3621,6 +4925,8 @@ relationship: RO:0002203 CL:0000746 ! cardiac muscle cell [Term] id: CL:0010022 name: cardiac neuron +def: "A neuron that has its soma in the heart." [PMID:12486170, PMID:29265764] +comment: This term is used in 3 GO terms that were created as part of the heart development focus project. is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000948 ! heart @@ -3629,6 +4935,7 @@ relationship: RO:0002100 UBERON:0000948 ! heart [Term] id: CL:0011001 name: spinal cord motor neuron +def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv] is_a: CL:0000100 ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron @@ -3638,6 +4945,7 @@ relationship: RO:0002100 UBERON:0002240 ! spinal cord [Term] id: CL:0011007 name: paraxial cell +def: "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." [GOC:NV, PMID:11687492] is_a: CL:0000222 ! mesodermal cell intersection_of: CL:0000222 ! mesodermal cell intersection_of: BFO:0000050 UBERON:0003059 ! part of presomitic mesoderm @@ -3646,6 +4954,7 @@ relationship: BFO:0000050 UBERON:0003059 ! part of presomitic mesoderm [Term] id: CL:0011012 name: neural crest cell +def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0002-9900-7880] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002321 ! embryonic cell (metazoa) @@ -3680,6 +4989,7 @@ relationship: BFO:0000050 UBERON:0001068 ! part of skin of back [Term] id: CL:0011026 name: progenitor cell +def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3] is_a: BFO:0000002 is_a: CL:0011115 ! precursor cell intersection_of: CL:0011115 ! precursor cell @@ -3689,6 +4999,7 @@ relationship: RO:0002202 CL:0000034 ! stem cell [Term] id: CL:0011027 name: skeletal muscle fibroblast +def: "Any fibroblast that is part of skeletal muscle tissue." [https://orcid.org/0000-0001-6164-0667, PMID:28369879] is_a: CL:0000188 ! cell of skeletal muscle is_a: CL:1001609 ! muscle fibroblast intersection_of: CL:0000057 ! fibroblast @@ -3697,14 +5008,26 @@ intersection_of: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue [Term] id: CL:0011030 name: dermal microvascular endothelial cell +def: "Any microvascular endothelial cell that is part of the dermis." [BTO:0004574, CL:patterns/cellPartOfAnatomicalEntity] is_a: CL:2000008 ! microvascular endothelial cell is_a: CL:2000010 ! dermis blood vessel endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis +[Term] +id: CL:0011108 +name: colon epithelial cell +def: "Epithelial cell that is part of the colon epithelium." [GOC:NV] +is_a: CL:0002253 ! epithelial cell of large intestine +intersection_of: CL:0000066 ! epithelial cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0000397 ! part of colonic epithelium + [Term] id: CL:0011115 name: precursor cell +def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos] +comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002215 GO:0030154 ! capable of cell differentiation @@ -3713,6 +5036,7 @@ relationship: RO:0002215 GO:0030154 ! capable of cell differentiation [Term] id: CL:0017500 name: neutrophillic cytoplasm +def: "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." [GOC:add] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0070046 ! bearer of @@ -3721,6 +5045,7 @@ relationship: RO:0000053 PATO:0070046 ! bearer of [Term] id: CL:0017502 name: acidophilic cytoplasm +def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." [GOC:add] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0002418 ! bearer of @@ -3729,6 +5054,7 @@ relationship: RO:0000053 PATO:0002418 ! bearer of [Term] id: CL:0017503 name: basophilic cytoplasm +def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0002094 ! bearer of @@ -3737,6 +5063,7 @@ relationship: RO:0000053 PATO:0002094 ! bearer of [Term] id: CL:0017504 name: polychromatophilic cytoplasm +def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: RO:0000053 PATO:0070047 ! bearer of @@ -3759,29 +5086,58 @@ is_a: CL:0000138 ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0019018 name: blood vessel smooth muscle cell +def: "A smooth muscle cell that is part of any blood vessel." [PMID:9108778] is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:0019019 name: tracheobronchial smooth muscle cell +def: "A smooth muscle cell that is part of the tracheobronchial tree." [PMID:10853867] is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:0019020 +name: extrahepatic cholangiocyte +def: "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." [PMID:23720296] +is_a: CL:1000488 ! cholangiocyte +intersection_of: CL:1000488 ! cholangiocyte +intersection_of: BFO:0000050 UBERON:0004822 ! part of extrahepatic bile duct epithelium +relationship: BFO:0000050 UBERON:0004822 ! part of extrahepatic bile duct epithelium + +[Term] +id: CL:0019021 +name: endothelial cell of periportal hepatic sinusoid +def: "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." [PMID:27423426] +xref: EFO:0010705 +is_a: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: RO:0002220 UBERON:0001279 ! adjacent to portal triad +relationship: RO:0002220 UBERON:0001279 ! adjacent to portal triad + +[Term] +id: CL:0019022 +name: endothelial cell of pericentral hepatic sinusoid +def: "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." [PMID:27423426] +xref: EFO:0010706 +is_a: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid +intersection_of: RO:0002220 UBERON:0006841 ! adjacent to central vein of liver +relationship: RO:0002220 UBERON:0006841 ! adjacent to central vein of liver [Term] id: CL:1000222 name: stomach neuroendocrine cell +def: "Any neuroendocrine cell that is part of some stomach." [FBC:Autogenerated] is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000165 ! neuroendocrine cell is_a: CL:0002659 ! glandular cell of stomach @@ -3791,6 +5147,7 @@ intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: CL:1000223 name: lung neuroendocrine cell +def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [doi:10.3109/01902148209069653, doi:10.7554/eLife.78216, PMID:33355253] is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000165 ! neuroendocrine cell @@ -3801,20 +5158,20 @@ intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000051 GO:0031045 ! has part dense core granule relationship: RO:0002215 GO:0070483 ! capable of detection of hypoxia -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000271 name: lung ciliated cell +def: "Any ciliated cell that is part of some lung." [FBC:Autogenerated] is_a: CL:4030034 ! respiratory ciliated cell intersection_of: CL:0000064 ! ciliated cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000272 name: lung secretory cell +def: "Any secretory cell that is part of some lung." [FBC:Autogenerated] is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -3825,9 +5182,71 @@ id: CL:1000274 name: trophectodermal cell is_a: CL:0000349 ! extraembryonic cell +[Term] +id: CL:1000275 +name: smooth muscle cell of small intestine +def: "A smooth muscle cell that is part of the small intestine." [GOC:tfm] +xref: FMA:15050 +is_a: CL:0002504 ! enteric smooth muscle cell +intersection_of: CL:0002504 ! enteric smooth muscle cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: CL:1000276 +name: smooth muscle fiber of duodenum +def: "A smooth muscle cell that is part of the duodenum." [GOC:tfm] +xref: FMA:15058 +is_a: CL:1000275 ! smooth muscle cell of small intestine +intersection_of: CL:1000275 ! smooth muscle cell of small intestine +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + +[Term] +id: CL:1000279 +name: smooth muscle cell of large intestine +def: "A smooth muscle cell that is part of the large intestine." [GOC:tfm] +xref: FMA:15653 +is_a: CL:0002504 ! enteric smooth muscle cell +intersection_of: CL:0002504 ! enteric smooth muscle cell +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine + +[Term] +id: CL:1000280 +name: smooth muscle cell of colon +def: "A smooth muscle cell that is part of the colon." [GOC:tfm] +xref: FMA:15663 +is_a: CL:1000279 ! smooth muscle cell of large intestine +intersection_of: CL:0002504 ! enteric smooth muscle cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:1000285 +name: smooth muscle cell of sigmoid colon +def: "A smooth muscle cell that is part of the sigmoid colon." [GOC:tfm] +xref: FMA:17521 +is_a: CL:1000280 ! smooth muscle cell of colon +intersection_of: CL:1000280 ! smooth muscle cell of colon +intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon +relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon + +[Term] +id: CL:1000286 +name: smooth muscle cell of rectum +def: "A smooth muscle cell that is part of the rectum." [GOC:tfm] +xref: FMA:17522 +is_a: CL:1000279 ! smooth muscle cell of large intestine +intersection_of: CL:0000192 ! smooth muscle cell +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + [Term] id: CL:1000303 name: fibroblast of areolar connective tissue +def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm] +xref: FMA:261279 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0006815 ! part of areolar connective tissue @@ -3836,6 +5255,8 @@ relationship: BFO:0000050 UBERON:0006815 ! part of areolar connective tissue [Term] id: CL:1000306 name: fibroblast of tunica adventitia of artery +def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm] +xref: FMA:261285 is_a: CL:0000057 ! fibroblast is_a: CL:0002503 ! adventitial cell intersection_of: CL:0000057 ! fibroblast @@ -3845,6 +5266,8 @@ relationship: BFO:0000050 UBERON:0005734 ! part of tunica adventitia of blood ve [Term] id: CL:1000307 name: fibroblast of dense regular elastic tissue +def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm] +xref: FMA:261287 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0007846 ! part of dense regular connective tissue @@ -3854,14 +5277,17 @@ relationship: BFO:0000050 UBERON:0007846 ! part of dense regular connective tiss [Term] id: CL:1000309 name: epicardial adipocyte +def: "An adipocyte that is part of the epicardial fat." [GOC:tfm] +xref: FMA:261293 is_a: CL:0000136 ! adipocyte is_a: CL:0002494 ! cardiocyte relationship: BFO:0000050 UBERON:0002348 ! part of epicardium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000310 name: adipocyte of epicardial fat of right ventricle +def: "An adipocyte that is part of the epicardial fat of right ventricle." [GOC:tfm] +xref: FMA:261297 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle @@ -3870,6 +5296,8 @@ relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle [Term] id: CL:1000311 name: adipocyte of epicardial fat of left ventricle +def: "An adipocyte that is part of the epicardial fat of left ventricle." [GOC:tfm] +xref: FMA:261300 is_a: CL:1000309 ! epicardial adipocyte intersection_of: CL:1000309 ! epicardial adipocyte intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle @@ -3878,24 +5306,28 @@ relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle [Term] id: CL:1000330 name: serous cell of epithelium of trachea +def: "A serous secreting cell that is part of the epithelium of trachea." [GOC:tfm] +xref: FMA:263078 is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea relationship: BFO:0000050 UBERON:0001901 ! part of epithelium of trachea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000331 name: serous cell of epithelium of bronchus +def: "A serous secreting cell that is part of the epithelium of bronchus." [GOC:tfm] +xref: FMA:263080 is_a: CL:0019001 ! tracheobronchial serous cell intersection_of: CL:0000313 ! serous secreting cell intersection_of: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000332 name: serous cell of epithelium of terminal bronchiole +def: "A serous secreting cell that is part of the epithelium of terminal bronchiole." [GOC:tfm] +xref: FMA:263082 is_a: CL:0019001 ! tracheobronchial serous cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000313 ! serous secreting cell @@ -3905,6 +5337,8 @@ relationship: BFO:0000050 UBERON:0001958 ! part of terminal bronchiole epitheliu [Term] id: CL:1000361 name: transitional myocyte of interatrial septum +def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm] +xref: FMA:263152 is_a: CL:0002073 ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte @@ -3914,6 +5348,8 @@ relationship: BFO:0000050 UBERON:0002085 ! part of interatrial septum [Term] id: CL:1000362 name: transitional myocyte of interventricular septum +def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm] +xref: FMA:263154 is_a: CL:0002073 ! transitional myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002073 ! transitional myocyte @@ -3923,15 +5359,31 @@ relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum [Term] id: CL:1000376 name: Purkinje myocyte of interventricular septum +def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm] +xref: FMA:263182 is_a: CL:0002068 ! Purkinje myocyte is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002068 ! Purkinje myocyte intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum +[Term] +id: CL:1000398 +name: endothelial cell of hepatic sinusoid +def: "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." [GOC:tfm, PMID:3926620] +xref: BTO:000125 +xref: FMA:62911 +is_a: CL:0000666 ! fenestrated endothelial cell +is_a: CL:0002262 ! endothelial cell of sinusoid +intersection_of: CL:0000115 ! endothelial cell +intersection_of: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid +relationship: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid + [Term] id: CL:1000409 name: myocyte of sinoatrial node +def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm] +xref: FMA:67102 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell intersection_of: CL:0000187 ! muscle cell @@ -3941,6 +5393,8 @@ relationship: BFO:0000050 UBERON:0002351 ! part of sinoatrial node [Term] id: CL:1000410 name: myocyte of atrioventricular node +def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm] +xref: FMA:67106 is_a: CL:0002072 ! nodal myocyte is_a: CL:0008009 ! transversely striated visceral muscle cell is_a: CL:2000022 ! cardiac septum cell @@ -3951,33 +5405,51 @@ relationship: BFO:0000050 UBERON:0002352 ! part of atrioventricular node [Term] id: CL:1000412 name: endothelial cell of arteriole +def: "An endothelial cell that is part of the arteriole." [GOC:tfm] +xref: FMA:67760 +xref: KUPO:0001097 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001980 ! part of arteriole relationship: BFO:0000050 UBERON:0001980 ! part of arteriole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000413 name: endothelial cell of artery +def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm] +xref: BTO:0004758 +xref: FMA:67761 +xref: KUPO:0001095 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0001917 ! part of endothelium of artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000414 name: endothelial cell of venule +def: "An endothelial cell that is part of the venule." [GOC:tfm] +xref: FMA:67762 is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0001979 ! part of venule relationship: BFO:0000050 UBERON:0001979 ! part of venule -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:1000415 +name: epithelial cell of gallbladder +def: "An epithelial cell that is part of the gallbladder." [GOC:tfm] +xref: FMA:67780 +is_a: CL:0000066 ! epithelial cell +intersection_of: CL:0000066 ! epithelial cell +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder [Term] id: CL:1000428 name: stem cell of epidermis +def: "A somatic stem cell that is part of the epidermis." [GOC:tfm] +xref: FMA:70541 is_a: CL:0000723 ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis @@ -3986,6 +5458,8 @@ relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis [Term] id: CL:1000443 name: ciliary muscle cell +def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm] +xref: FMA:70610 is_a: CL:0000192 ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0001775 ! part of ciliary body @@ -3994,6 +5468,8 @@ relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body [Term] id: CL:1000444 name: mesothelial cell of anterior chamber of eye +def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm] +xref: FMA:70615 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball @@ -4002,6 +5478,8 @@ relationship: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball [Term] id: CL:1000456 name: mesothelial cell of parietal peritoneum +def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm] +xref: FMA:72142 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001366 ! part of parietal peritoneum @@ -4010,15 +5488,18 @@ relationship: BFO:0000050 UBERON:0001366 ! part of parietal peritoneum [Term] id: CL:1000457 name: mesothelial cell of visceral peritoneum +def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm] +xref: FMA:72143 is_a: CL:1000490 ! mesothelial cell of peritoneum intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum relationship: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:1000478 name: transitional myocyte of sinoatrial node +def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm] +xref: FMA:83384 is_a: CL:0002073 ! transitional myocyte is_a: CL:1000409 ! myocyte of sinoatrial node intersection_of: CL:0002073 ! transitional myocyte @@ -4027,6 +5508,8 @@ intersection_of: BFO:0000050 UBERON:0002351 ! part of sinoatrial node [Term] id: CL:1000479 name: Purkinje myocyte of atrioventricular node +def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm] +xref: FMA:83386 is_a: CL:0002068 ! Purkinje myocyte is_a: CL:1000410 ! myocyte of atrioventricular node intersection_of: CL:0002068 ! Purkinje myocyte @@ -4035,15 +5518,32 @@ intersection_of: BFO:0000050 UBERON:0002352 ! part of atrioventricular node [Term] id: CL:1000482 name: myocardial endocrine cell of interventricular septum +def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm] +xref: FMA:83390 is_a: CL:0002074 ! myocardial endocrine cell is_a: CL:2000022 ! cardiac septum cell intersection_of: CL:0002074 ! myocardial endocrine cell intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum +[Term] +id: CL:1000488 +name: cholangiocyte +def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246] +xref: FMA:86481 +is_a: BFO:0000002 +is_a: CL:0000069 ! branched duct epithelial cell +intersection_of: CL:0000069 ! branched duct epithelial cell +intersection_of: BFO:0000050 UBERON:0002394 ! part of bile duct +intersection_of: RO:0002215 GO:0015106 ! capable of bicarbonate transmembrane transporter activity +relationship: BFO:0000050 UBERON:0002394 ! part of bile duct +relationship: RO:0002202 CL:0005026 ! hepatoblast + [Term] id: CL:1000490 name: mesothelial cell of peritoneum +def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm] +xref: FMA:86736 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum @@ -4052,6 +5552,8 @@ relationship: BFO:0000050 UBERON:0002358 ! part of peritoneum [Term] id: CL:1000491 name: mesothelial cell of pleura +def: "A mesothelial cell that is part of the pleura." [GOC:tfm] +xref: FMA:86737 is_a: CL:0000077 ! mesothelial cell intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0000977 ! part of pleura @@ -4060,6 +5562,8 @@ relationship: BFO:0000050 UBERON:0000977 ! part of pleura [Term] id: CL:1000492 name: mesothelial cell of parietal pleura +def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm] +xref: FMA:86738 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002400 ! part of parietal pleura @@ -4068,15 +5572,36 @@ relationship: BFO:0000050 UBERON:0002400 ! part of parietal pleura [Term] id: CL:1000493 name: mesothelial cell of visceral pleura +def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm] +xref: FMA:86739 is_a: CL:1000491 ! mesothelial cell of pleura intersection_of: CL:0000077 ! mesothelial cell intersection_of: BFO:0000050 UBERON:0002401 ! part of visceral pleura relationship: BFO:0000050 UBERON:0002401 ! part of visceral pleura -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:1001433 +name: epithelial cell of exocrine pancreas +def: "An epithelial cell of the exocrine pancreas." [GOC:tfm] +xref: FMA:70986 +is_a: CL:0000083 ! epithelial cell of pancreas +intersection_of: CL:0000066 ! epithelial cell +intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas + +[Term] +id: CL:1001516 +name: intestinal enteroendocrine cell +def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." [MP:0010802] +is_a: CL:0000164 ! enteroendocrine cell +is_a: CL:0002563 ! intestinal epithelial cell +intersection_of: CL:0000164 ! enteroendocrine cell +intersection_of: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa [Term] id: CL:1001567 name: lung endothelial cell +def: "Any endothelial cell of vascular tree that is part of some lung." [FBC:Autogenerated] is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -4085,24 +5610,105 @@ relationship: BFO:0000050 UBERON:0000102 ! part of lung vasculature [Term] id: CL:1001568 name: pulmonary artery endothelial cell +def: "Any endothelial cell of vascular tree that is part of some pulmonary artery." [FBC:Autogenerated] +xref: BTO:0001141 is_a: CL:1000413 ! endothelial cell of artery intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery relationship: BFO:0000050 UBERON:0005317 ! part of pulmonary artery endothelium -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:1001572 +name: colon endothelial cell +def: "A vascular endothelial cell found in colon blood vessels." [https://orcid.org/0000-0001-5208-3432, NPX:PDR] +xref: CALOHA:TS-2397 +is_a: CL:0000115 ! endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0013695 ! part of colon endothelium [Term] id: CL:1001576 name: oral mucosa squamous cell +def: "Squamous cell of oral epithelium." [NPX:PDR] +xref: CALOHA:TS-1252 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: BFO:0000050 UBERON:0002424 ! part of oral epithelium relationship: BFO:0000050 UBERON:0002424 ! part of oral epithelium +[Term] +id: CL:1001588 +name: colon glandular cell +def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] +xref: CALOHA:TS-1274 +is_a: CL:0002658 ! glandular cell of the large intestine +is_a: CL:0011108 ! colon epithelial cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: CL:1001589 +name: duodenum glandular cell +def: "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." [NPX:PDR] +xref: CALOHA:TS-1275 +is_a: CL:1001598 ! small intestine glandular cell +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0008346 ! part of duodenal epithelium + +[Term] +id: CL:1001592 +name: gallbladder glandular cell +def: "Glandular cell of gallbladder epithelium." [NPX:PDR] +xref: CALOHA:TS-1278 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:1000415 ! epithelial cell of gallbladder +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002029 ! part of epithelium of gall bladder + +[Term] +id: CL:1001595 +name: rectum glandular cell +def: "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR] +xref: CALOHA:TS-1281 +is_a: CL:0002658 ! glandular cell of the large intestine +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0003354 ! part of epithelium of rectum + +[Term] +id: CL:1001598 +name: small intestine glandular cell +def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." [NCI_Thesaurus:Small_Intestinal_Glandular_Cell, NPX:PDR] +xref: CALOHA:TS-1286 +xref: FMA:86928 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0002254 ! epithelial cell of small intestine +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine + +[Term] +id: CL:1001599 +name: pancreas exocrine glandular cell +def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." [HPA:HPA, NPX:PDR] +xref: BTO:0000028 +xref: CALOHA:TS-1242 +is_a: CL:0000150 ! glandular epithelial cell +is_a: CL:0000152 ! exocrine cell +is_a: CL:1001433 ! epithelial cell of exocrine pancreas +intersection_of: CL:0000150 ! glandular epithelial cell +intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000050 UBERON:0013697 ! part of exocrine pancreas epithelium + [Term] id: CL:1001603 name: lung macrophage +def: "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." [HPA:HPA, NPX:PDR] +xref: CALOHA:TS-0576 is_a: CL:0000235 ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -4111,6 +5717,8 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: CL:1001609 name: muscle fibroblast +def: "Fibroblast from muscle organ." [NPX:PDR] +xref: CALOHA:TS-0643 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001630 ! part of muscle organ @@ -4119,6 +5727,8 @@ relationship: BFO:0000050 UBERON:0001630 ! part of muscle organ [Term] id: CL:1001610 name: bone marrow hematopoietic cell +def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR] +xref: CALOHA:TS-2109 is_a: CL:0000988 ! hematopoietic cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000988 ! hematopoietic cell @@ -4128,6 +5738,7 @@ relationship: BFO:0000050 UBERON:0012429 ! part of hematopoietic tissue [Term] id: CL:2000001 name: peripheral blood mononuclear cell +def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [GOC:TermGenie] is_a: CL:0000080 ! circulating cell is_a: CL:0000842 ! mononuclear cell intersection_of: CL:0000842 ! mononuclear cell @@ -4137,6 +5748,7 @@ relationship: BFO:0000050 UBERON:0000178 ! part of blood [Term] id: CL:2000008 name: microvascular endothelial cell +def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium @@ -4145,6 +5757,7 @@ relationship: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium [Term] id: CL:2000010 name: dermis blood vessel endothelial cell +def: "Any blood vessel endothelial cell that is part of a dermis." [GOC:TermGenie] is_a: CL:0000071 ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis @@ -4153,6 +5766,7 @@ relationship: BFO:0000050 UBERON:0002067 ! part of dermis [Term] id: CL:2000013 name: fibroblast of skin of abdomen +def: "Any skin fibroblast that is part of a skin of abdomen." [GOC:TermGenie] is_a: CL:0002620 ! skin fibroblast intersection_of: CL:0002620 ! skin fibroblast intersection_of: BFO:0000050 UBERON:0001416 ! part of skin of abdomen @@ -4161,6 +5775,7 @@ relationship: BFO:0000050 UBERON:0001416 ! part of skin of abdomen [Term] id: CL:2000016 name: lung microvascular endothelial cell +def: "Any lung endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie] is_a: CL:1001567 ! lung endothelial cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:1001567 ! lung endothelial cell @@ -4169,6 +5784,7 @@ intersection_of: BFO:0000050 UBERON:0008339 ! part of microvascular endothelium [Term] id: CL:2000019 name: compound eye photoreceptor cell +def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie] is_a: CL:0000287 ! eye photoreceptor cell intersection_of: CL:0000210 ! photoreceptor cell intersection_of: BFO:0000050 UBERON:0000018 ! part of compound eye @@ -4177,6 +5793,7 @@ relationship: BFO:0000050 UBERON:0000018 ! part of compound eye [Term] id: CL:2000020 name: inner cell mass cell +def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0000087 ! part of inner cell mass @@ -4185,6 +5802,7 @@ relationship: BFO:0000050 UBERON:0000087 ! part of inner cell mass [Term] id: CL:2000022 name: cardiac septum cell +def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie] is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0002099 ! part of cardiac septum @@ -4193,6 +5811,7 @@ relationship: BFO:0000050 UBERON:0002099 ! part of cardiac septum [Term] id: CL:2000029 name: central nervous system neuron +def: "Any neuron that is part of a central nervous system." [GOC:TermGenie] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0001017 ! central nervous system @@ -4201,15 +5820,17 @@ relationship: RO:0002100 UBERON:0001017 ! central nervous system [Term] id: CL:2000032 name: peripheral nervous system neuron +def: "A neuron that is part of a peripheral nervous system." [GOC:TermGenie, ISBN:0721662544] +xref: FMA:84664 is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002100 UBERON:0000010 ! peripheral nervous system relationship: RO:0002100 UBERON:0000010 ! peripheral nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:2000042 name: embryonic fibroblast +def: "Any fibroblast that is part of a embryo." [GOC:TermGenie] is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -4218,6 +5839,7 @@ relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: CL:2000043 name: brain pericyte +def: "Any pericyte cell that is part of a brain." [GOC:TermGenie] is_a: CL:0002575 ! central nervous system pericyte intersection_of: CL:0000669 ! pericyte intersection_of: BFO:0000050 UBERON:0000955 ! part of brain @@ -4226,6 +5848,7 @@ relationship: BFO:0000050 UBERON:0000955 ! part of brain [Term] id: CL:2000044 name: brain microvascular endothelial cell +def: "Any microvascular endothelial cell that is part of a brain." [GOC:TermGenie] is_a: CL:0002319 ! neural cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell @@ -4235,6 +5858,7 @@ relationship: BFO:0000050 UBERON:0000955 ! part of brain [Term] id: CL:2000046 name: ventricular cardiac muscle cell +def: "Any cardiac muscle cell that is part of a cardiac ventricle." [GOC:TermGenie] is_a: CL:0000746 ! cardiac muscle cell intersection_of: CL:0000746 ! cardiac muscle cell intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -4243,15 +5867,47 @@ relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle [Term] id: CL:2000047 name: brainstem motor neuron +def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie] is_a: CL:0000100 ! motor neuron is_a: CL:2000029 ! central nervous system neuron intersection_of: CL:0000100 ! motor neuron intersection_of: RO:0002100 UBERON:0002298 ! brainstem relationship: RO:0002100 UBERON:0002298 ! brainstem +[Term] +id: CL:2000051 +name: splenic fibroblast +def: "Any fibroblast that is part of a spleen." [GOC:TermGenie] +is_a: CL:0000057 ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + +[Term] +id: CL:2000053 +name: splenic endothelial cell +def: "Any endothelial cell that is part of a spleen." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5500 +is_a: CL:0000115 ! endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + +[Term] +id: CL:2000055 +name: liver dendritic cell +def: "Any dendritic cell that is part of a liver." [GOC:TermGenie] +comment: http://www.jleukbio.org/content/66/2/322.abstract +is_a: CL:0000451 ! dendritic cell +intersection_of: CL:0000451 ! dendritic cell +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: CL:2000063 name: ovarian fibroblast +def: "Any fibroblast that is part of a female gonad." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7330 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary @@ -4260,6 +5916,8 @@ relationship: BFO:0000050 UBERON:0000992 ! part of ovary [Term] id: CL:2000064 name: ovarian surface epithelial cell +def: "Any epithelial cell that is part of a female gonad." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7310 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary @@ -4268,32 +5926,48 @@ relationship: BFO:0000050 UBERON:0000992 ! part of ovary [Term] id: CL:2000066 name: cardiac ventricle fibroblast +def: "Any fibroblast that is part of a cardiac ventricle." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6310 is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:2000067 name: cardiac atrium fibroblast +def: "Any fibroblast that is part of a cardiac atrium." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6320 is_a: CL:0002548 ! fibroblast of cardiac tissue intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:2000068 name: pericardium fibroblast +def: "Any fibroblast that is part of a pericardium." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6430 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0002407 ! part of pericardium relationship: BFO:0000050 UBERON:0002407 ! part of pericardium +[Term] +id: CL:2000069 +name: gallbladder fibroblast +def: "Any fibroblast that is part of a gallbladder." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5430 +is_a: CL:0000057 ! fibroblast +intersection_of: CL:0000057 ! fibroblast +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder + [Term] id: CL:2000070 name: optic choroid fibroblast +def: "Any fibroblast that is part of a optic choroid." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6620 is_a: CL:0000057 ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: BFO:0000050 UBERON:0001776 ! part of optic choroid @@ -4302,6 +5976,8 @@ relationship: BFO:0000050 UBERON:0001776 ! part of optic choroid [Term] id: CL:2000072 name: adipose microvascular endothelial cell +def: "Any microvascular endothelial cell that is part of a adipose tissue." [GOC:TermGenie] +comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7200 is_a: CL:0002320 ! connective tissue cell is_a: CL:2000008 ! microvascular endothelial cell intersection_of: CL:2000008 ! microvascular endothelial cell @@ -4311,14 +5987,26 @@ relationship: BFO:0000050 UBERON:0001013 ! part of adipose tissue [Term] id: CL:2000073 name: migratory cardiac neural crest cell +def: "Any migratory neural crest cell that is part of a cardiac neural crest." [GOC:TermGenie] is_a: CL:0000333 ! migratory neural crest cell intersection_of: CL:0000333 ! migratory neural crest cell intersection_of: BFO:0000050 UBERON:0000095 ! part of cardiac neural crest relationship: BFO:0000050 UBERON:0000095 ! part of cardiac neural crest +[Term] +id: CL:2000074 +name: splenocyte +def: "Any leukocyte that is part of a spleen." [GOC:TermGenie] +comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. +is_a: CL:0000738 ! leukocyte +intersection_of: CL:0000738 ! leukocyte +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + [Term] id: CL:2000080 name: mesenchymal stem cell of abdominal adipose tissue +def: "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." [GOC:TermGenie] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -4327,6 +6015,7 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: CL:2000093 name: bronchus fibroblast of lung +def: "Any fibroblast of lung that is part of a bronchus." [GOC:TermGenie] is_a: CL:0002553 ! fibroblast of lung intersection_of: CL:0002553 ! fibroblast of lung intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus @@ -4335,6 +6024,7 @@ relationship: BFO:0000050 UBERON:0002185 ! part of bronchus [Term] id: CL:3000000 name: ciliated epithelial cell of esophagus +def: "A ciliated epithelial cell of the esophagus." [GOC:CellBLAST, PMID:29802404] is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus intersection_of: CL:0000067 ! ciliated epithelial cell @@ -4344,6 +6034,7 @@ relationship: BFO:0000050 UBERON:0001976 ! part of epithelium of esophagus [Term] id: CL:3000004 name: peripheral sensory neuron +def: "Peripheral sensory neuron." [GOC:CellBLAST, PMID:30096314] is_a: CL:0000101 ! sensory neuron is_a: CL:2000032 ! peripheral nervous system neuron intersection_of: CL:2000032 ! peripheral nervous system neuron @@ -4352,25 +6043,26 @@ intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involv [Term] id: CL:4023072 name: brain vascular cell +def: "A cell that is part of the brain vasculature." [DOI:10.1101/2022.10.12.511898] is_a: CL:0002319 ! neural cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0008998 ! part of vasculature of brain relationship: BFO:0000050 UBERON:0008998 ! part of vasculature of brain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4023079 name: midbrain-derived inhibitory neuron +def: "A GABAergic inhibitory neuron that is derived from the midbrain." [DOI:10.1101/2022.10.12.511898] is_a: CL:0000540 ! neuron is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: CL:0000540 ! neuron intersection_of: RO:0002202 UBERON:0001891 ! midbrain relationship: RO:0002202 UBERON:0001891 ! midbrain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4023168 name: somatosensory neuron +def: "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." [PMID:22865660] is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: BFO:0000050 UBERON:0003942 ! part of somatosensory system @@ -4389,22 +6081,27 @@ relationship: BFO:0000050 UBERON:0016405 ! part of pulmonary capillary [Term] id: CL:4028004 name: alveolar type 1 fibroblast cell +def: "A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets." [PMID:22268140, PMID:26706109, PMID:28886382, PMID:29489752, PMID:30675802, PMID:33624948, PMID:33707239, PMID:9074756] +comment: A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7. {xref="https://doi.org/10.5281/zenodo.11165918"} is_a: CL:0002241 ! pulmonary interstitial fibroblast is_a: CL:0002553 ! fibroblast of lung relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung -property_value: RO:0002175 NCBITaxon:9606 +relationship: RO:0015004 CL:4037002 ! has characterizing marker set NS forest marker set of alveolar type 1 fibroblast cell (Human Lung). [Term] id: CL:4028006 name: alveolar adventitial fibroblast +def: "A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia." [PMID:26706109, PMID:28886382, PMID:29752282, PMID:30675802, PMID:33208946, PMID:33624948] +comment: A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85. {xref="https://doi.org/10.5281/zenodo.11165918"} is_a: CL:0002241 ! pulmonary interstitial fibroblast is_a: CL:0002553 ! fibroblast of lung relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung -property_value: RO:0002175 NCBITaxon:9606 +relationship: RO:0015004 CL:4037001 ! has characterizing marker set NS forest marker set of alveolar adventitial fibroblast (Human Lung). [Term] id: CL:4030029 name: blood lymphocyte +def: "A lymphocyte located in blood." [https://orcid.org/0000-0001-9990-8331] is_a: CL:0000542 ! lymphocyte is_a: CL:2000001 ! peripheral blood mononuclear cell intersection_of: CL:0000542 ! lymphocyte @@ -4413,6 +6110,7 @@ intersection_of: BFO:0000050 UBERON:0000178 ! part of blood [Term] id: CL:4030031 name: interstitial cell +def: "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes." [PMID:24987007] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: BFO:0000050 UBERON:0005169 ! part of interstitial tissue @@ -4421,130 +6119,186 @@ relationship: BFO:0000050 UBERON:0005169 ! part of interstitial tissue [Term] id: CL:4030034 name: respiratory ciliated cell +def: "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium." [PMID:18757316, PMID:21364219] is_a: CL:0000064 ! ciliated cell intersection_of: CL:0000064 ! ciliated cell intersection_of: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium relationship: BFO:0000050 UBERON:0004802 ! part of respiratory tract epithelium +[Term] +id: CL:4033005 +name: serous secreting cell of bronchus submucosal gland +def: "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland." [PMID:5487122, PMID:9651178] +is_a: CL:0000152 ! exocrine cell +is_a: CL:0019001 ! tracheobronchial serous cell +intersection_of: CL:0000313 ! serous secreting cell +intersection_of: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland +relationship: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland + [Term] id: CL:4033008 name: vein endothelial cell of respiratory system +def: "A(n) vein endothelial cell that is part of a(n) respiratory system." [PMID:34030460] is_a: CL:0002543 ! vein endothelial cell intersection_of: CL:0002543 ! vein endothelial cell intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033017 name: bronchiolar smooth muscle cell +def: "A smooth muscle cell that is part of a bronchiole." [ISBN:9781260462982, PMID:15347627] is_a: CL:0019019 ! tracheobronchial smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: BFO:0000050 UBERON:0002186 ! part of bronchiole relationship: BFO:0000050 UBERON:0004515 ! part of smooth muscle tissue of bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: CL:4033018 name: lung megakaryocyte +def: "A megakaryocyte that is resident in the lung connective tissue." [PMID:33351116] is_a: CL:0000556 ! megakaryocyte is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000556 ! megakaryocyte intersection_of: BFO:0000050 UBERON:0000114 ! part of lung connective tissue relationship: BFO:0000050 UBERON:0000114 ! part of lung connective tissue -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: CL:4033020 +name: mucus secreting cell of trachea gland +def: "A mucus secreting cell that is part of a submucosal gland of the trachea." [PMID:18931053, PMID:29656943] +is_a: CL:0000307 ! tracheal epithelial cell +is_a: CL:4033037 ! mucus secreting cell of tracheobronchial tree submucosal gland +intersection_of: CL:0000319 ! mucus secreting cell +intersection_of: BFO:0000050 UBERON:0005203 ! part of trachea gland +relationship: BFO:0000050 UBERON:0005203 ! part of trachea gland + +[Term] +id: CL:4033022 +name: mucus secreting cell of bronchus submucosal gland +def: "A mucus secreting cell of a submucosal gland of the bronchus." [PMID:19965983] +is_a: CL:0002328 ! bronchial epithelial cell +is_a: CL:4033037 ! mucus secreting cell of tracheobronchial tree submucosal gland +intersection_of: CL:0000319 ! mucus secreting cell +intersection_of: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland +relationship: BFO:0000050 UBERON:8410043 ! part of bronchus submucosal gland + +[Term] +id: CL:4033037 +name: mucus secreting cell of tracheobronchial tree submucosal gland +def: "A mucus secreting cell of a submucosal gland of the tracheobronchial tree." [PMID:30864819] +is_a: CL:0000152 ! exocrine cell +is_a: CL:0000319 ! mucus secreting cell +is_a: CL:0002202 ! epithelial cell of tracheobronchial tree +intersection_of: CL:0000319 ! mucus secreting cell +intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree +intersection_of: BFO:0000050 UBERON:8410077 ! part of airway submucosal gland +relationship: BFO:0000050 UBERON:8410077 ! part of airway submucosal gland [Term] id: CL:4033041 name: CCL3-positive alveolar macrophage +def: "An alveolar macrophage that expresses CCL3." [PMID:37291214] +comment: A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67. {xref="https://doi.org/10.5281/zenodo.11165918"} is_a: CL:0000583 ! alveolar macrophage relationship: RO:0002292 PR:000002123 -property_value: RO:0002175 NCBITaxon:9606 +relationship: RO:0015004 CL:4037004 ! has characterizing marker set NS forest marker set of CCL3-positive alveolar macrophage (Human Lung). [Term] id: CL:4033042 name: metallothionein-positive alveolar macrophage +def: "An alveolar macrophage that expresses metallothionein." [PMID:37291214] +comment: A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41. {xref="https://doi.org/10.5281/zenodo.11165918"} is_a: CL:0000583 ! alveolar macrophage -property_value: RO:0002175 NCBITaxon:9606 +relationship: RO:0015004 CL:4037005 ! has characterizing marker set NS forest marker set of metallothionein-positive alveolar macrophage (Human Lung). [Term] id: CL:4033054 name: perivascular cell +def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." [PMID:24928499, PMID:27889329] is_a: CL:0000000 ! cell intersection_of: CL:0000000 ! cell intersection_of: RO:0002220 UBERON:0002049 ! adjacent to vasculature relationship: RO:0002220 UBERON:0002049 ! adjacent to vasculature +[Term] +id: CL:4033061 +name: endothelial cell of central vein of liver +def: "An endothelial cell that is part of a central vein of liver." [PMID:28287163] +is_a: CL:0002543 ! vein endothelial cell +intersection_of: CL:0000115 ! endothelial cell +intersection_of: BFO:0000050 UBERON:0006841 ! part of central vein of liver +relationship: BFO:0000050 UBERON:0006841 ! part of central vein of liver + [Term] id: CL:4037001 name: NS forest marker set of alveolar adventitial fibroblast (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/286133 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/57124 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000168079 ! has part SCARA5 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000174807 ! has part CD248 property_value: STATO:0000663 "0.85" xsd:string [Term] id: CL:4037002 name: NS forest marker set of alveolar type 1 fibroblast cell (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/4060 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/8639 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000131471 ! has part AOC3 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000139329 ! has part LUM property_value: STATO:0000663 "0.7" xsd:string [Term] id: CL:4037003 name: NS forest marker set of alveolar macrophage (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/2168 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/4481 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000038945 ! has part MSR1 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000170323 ! has part FABP4 property_value: STATO:0000663 "0.8" xsd:string [Term] id: CL:4037004 name: NS forest marker set of CCL3-positive alveolar macrophage (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/6374 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/79931 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000050730 ! has part TNIP3 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000163735 ! has part CXCL5 property_value: STATO:0000663 "0.67" xsd:string [Term] id: CL:4037005 name: NS forest marker set of metallothionein-positive alveolar macrophage (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/3162 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/3248 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000100292 ! has part HMOX1 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000164120 ! has part HPGD property_value: STATO:0000663 "0.41" xsd:string [Term] id: CL:4037006 name: NS forest marker set of cell (Human Lung). is_a: SO:0001260 ! sequence_collection -relationship: BFO:0000051 http://identifiers.org/ncbigene/11065 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/51203 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/6241 ! has part -relationship: BFO:0000051 http://identifiers.org/ncbigene/9768 ! has part +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000137804 ! has part NUSAP1 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000166803 ! has part PCLAF +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000171848 ! has part RRM2 +relationship: BFO:0000051 http://identifiers.org/ensembl/ENSG00000175063 ! has part UBE2C property_value: STATO:0000663 "0.26" xsd:string [Term] id: CL:4040003 name: fetal pre-type II pulmonary alveolar epithelial cell +def: "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity." [PMID:1316350] is_a: CL:0000322 ! pulmonary alveolar epithelial cell [Term] id: CL:4040004 name: mesenchymal stem cell of orbital adipose tissue +def: "Any mesenchymal stem cell of adipose tissue that is part of an orbital region." [https://orcid.org/0000-0002-0819-0473] is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue intersection_of: BFO:0000050 UBERON:0004088 ! part of orbital region relationship: BFO:0000050 UBERON:0004088 ! part of orbital region -[Term] -id: CLM:0000000 -name: root node - [Term] id: GO:0000011 name: vacuole inheritance +def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization is_a: GO:0048308 ! organelle inheritance intersection_of: GO:0048308 ! organelle inheritance @@ -4554,6 +6308,7 @@ relationship: GOREL:0002003 GO:0005773 ! results in distribution of vacuole [Term] id: GO:0000070 name: mitotic sister chromatid segregation +def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation @@ -4563,6 +6318,7 @@ relationship: BFO:0000050 GO:0140014 ! part of mitotic nuclear division [Term] id: GO:0000139 name: Golgi membrane +def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005794 ! bounding layer of Golgi apparatus @@ -4571,6 +6327,7 @@ relationship: RO:0002007 GO:0005794 ! bounding layer of Golgi apparatus [Term] id: GO:0000226 name: microtubule cytoskeleton organization +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process intersection_of: GO:0016043 ! cellular component organization @@ -4580,6 +6337,7 @@ relationship: RO:0002592 GO:0015630 ! results in organization of microtubule cyt [Term] id: GO:0000228 name: nuclear chromosome +def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: BFO:0000050 GO:0005634 ! part of nucleus @@ -4588,14 +6346,27 @@ relationship: BFO:0000050 GO:0031981 ! part of nuclear lumen [Term] id: GO:0000271 name: polysaccharide biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18154 ! has primary output relationship: RO:0004008 CHEBI:18154 ! has primary output +[Term] +id: GO:0000272 +name: polysaccharide catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:18154 ! has primary input +relationship: RO:0004009 CHEBI:18154 ! has primary input + [Term] id: GO:0000278 name: mitotic cell cycle +def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194] +comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. +xref: Wikipedia:Mitosis is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: BFO:0000051 GO:0140014 ! has part mitotic nuclear division @@ -4606,6 +6377,7 @@ relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! Eukaryota [Term] id: GO:0000280 name: nuclear division +def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] is_a: GO:0048285 ! organelle fission intersection_of: GO:0048285 ! organelle fission intersection_of: GOREL:0002004 GO:0005634 ! results in fission of nucleus @@ -4614,6 +6386,7 @@ relationship: GOREL:0002004 GO:0005634 ! results in fission of nucleus [Term] id: GO:0000313 name: organellar ribosome +def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] is_a: GO:0005840 ! ribosome intersection_of: GO:0005840 ! ribosome intersection_of: BFO:0000050 GO:0043226 ! part of organelle @@ -4622,11 +6395,13 @@ relationship: BFO:0000050 GO:0043226 ! part of organelle [Term] id: GO:0000323 name: lytic vacuole +def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000740 name: nuclear membrane fusion +def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0071763 ! nuclear membrane organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0061025 ! membrane fusion @@ -4636,6 +6411,8 @@ relationship: RO:0012008 GO:0031965 ! results in fusion of nuclear membrane [Term] id: GO:0000741 name: karyogamy +def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] +xref: Wikipedia:Karyogamy is_a: GO:0006997 ! nucleus organization is_a: GO:0048284 ! organelle fusion intersection_of: GO:0048284 ! organelle fusion @@ -4646,6 +6423,7 @@ relationship: RO:0012008 GO:0005634 ! results in fusion of nucleus [Term] id: GO:0000768 name: syncytium formation by plasma membrane fusion +def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] is_a: GO:0006949 ! syncytium formation is_a: GO:0140253 ! cell-cell fusion intersection_of: GO:0006949 ! syncytium formation @@ -4654,28 +6432,39 @@ intersection_of: BFO:0000051 GO:0045026 ! has part plasma membrane fusion [Term] id: GO:0000785 name: chromatin +def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] +comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. +xref: NIF_Subcellular:sao1615953555 is_a: GO:0032993 ! protein-DNA complex relationship: BFO:0000050 GO:0005694 ! part of chromosome [Term] id: GO:0000791 name: euchromatin +def: "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] +xref: NIF_Subcellular:sao445485807 +xref: Wikipedia:Euchromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000792 name: heterochromatin +def: "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] +xref: NIF_Subcellular:sao581845896 +xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000819 name: sister chromatid segregation +def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0051276 ! chromosome organization is_a: GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0000902 name: cell morphogenesis +def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000000 ! results in morphogenesis of cell @@ -4684,6 +6473,7 @@ relationship: RO:0002298 CL:0000000 ! results in morphogenesis of cell [Term] id: GO:0001501 name: skeletal system development +def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001434 ! results in development of skeletal system @@ -4692,6 +6482,9 @@ relationship: RO:0002296 UBERON:0001434 ! results in development of skeletal sys [Term] id: GO:0001503 name: ossification +def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] +comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. +xref: Wikipedia:Ossification is_a: GO:0032501 ! multicellular organismal process intersection_of: GO:0032501 ! multicellular organismal process intersection_of: RO:0002297 UBERON:0001474 ! results in formation of bone element @@ -4700,11 +6493,15 @@ relationship: RO:0002297 UBERON:0001474 ! results in formation of bone element [Term] id: GO:0001508 name: action potential +def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] +comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0001525 name: angiogenesis +def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] +xref: Wikipedia:Angiogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001981 ! results in formation of blood vessel @@ -4714,11 +6511,14 @@ relationship: RO:0002297 UBERON:0001981 ! results in formation of blood vessel [Term] id: GO:0001539 name: cilium or flagellum-dependent cell motility +def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] +comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. is_a: GO:0048870 ! cell motility [Term] id: GO:0001555 name: oocyte growth +def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048588 ! developmental cell growth intersection_of: GO:0040007 ! growth @@ -4731,6 +6531,8 @@ relationship: RO:0002343 CL:0000023 ! results in growth of oocyte [Term] id: GO:0001556 name: oocyte maturation +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/] +xref: Wikipedia:Oocyte_maturation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation @@ -4743,6 +6545,7 @@ relationship: RO:0002299 CL:0000023 ! results in maturation of oocyte [Term] id: GO:0001558 name: regulation of cell growth +def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation @@ -4752,6 +6555,7 @@ relationship: RO:0002211 GO:0016049 ! regulates cell growth [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus +def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] is_a: GO:0001558 ! regulation of cell growth intersection_of: GO:0001558 ! regulation of cell growth intersection_of: BFO:0000050 GO:0051716 ! part of cellular response to stimulus @@ -4760,6 +6564,7 @@ relationship: BFO:0000050 GO:0051716 ! part of cellular response to stimulus [Term] id: GO:0001568 name: blood vessel development +def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001981 ! results in development of blood vessel @@ -4769,6 +6574,7 @@ relationship: RO:0002296 UBERON:0001981 ! results in development of blood vessel [Term] id: GO:0001569 name: branching involved in blood vessel morphogenesis +def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube intersection_of: BFO:0000050 GO:0048514 ! part of blood vessel morphogenesis @@ -4777,6 +6583,8 @@ relationship: BFO:0000050 GO:0001525 ! part of angiogenesis [Term] id: GO:0001570 name: vasculogenesis +def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] +xref: Wikipedia:Vasculogenesis is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002297 UBERON:0001981 ! results in formation of blood vessel @@ -4786,6 +6594,7 @@ relationship: RO:0002297 UBERON:0001981 ! results in formation of blood vessel [Term] id: GO:0001578 name: microtubule bundle formation +def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: RO:0000057 GO:0005874 ! has participant microtubule relationship: RO:0002297 GO:0097427 ! results in formation of microtubule bundle @@ -4793,31 +6602,50 @@ relationship: RO:0002297 GO:0097427 ! results in formation of microtubule bundle [Term] id: GO:0001654 name: eye development +def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] +xref: Wikipedia:Eye_development is_a: GO:0007423 ! sensory organ development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000970 ! results in development of eye relationship: BFO:0000050 GO:0150063 ! part of visual system development relationship: RO:0002296 UBERON:0000970 ! results in development of eye +[Term] +id: GO:0001655 +name: urogenital system development +def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048731 ! system development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: RO:0002296 UBERON:0004122 ! results in development of genitourinary system +relationship: BFO:0000051 GO:0072001 ! has part renal system development +relationship: RO:0002296 UBERON:0004122 ! results in development of genitourinary system + [Term] id: GO:0001659 name: temperature homeostasis +def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl] +xref: Wikipedia:Thermoregulation is_a: GO:0048871 ! multicellular organismal-level homeostasis [Term] id: GO:0001666 name: response to hypoxia +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] +comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. is_a: GO:0006950 ! response to stress is_a: GO:0036293 ! response to decreased oxygen levels [Term] id: GO:0001667 name: ameboidal-type cell migration +def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] +comment: Note that this term refers to a mode of migration rather than to any particular cell type. is_a: GO:0016477 ! cell migration [Term] id: GO:0001674 name: female germ cell nucleus +def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] is_a: GO:0043073 ! germ cell nucleus intersection_of: GO:0005634 ! nucleus intersection_of: BFO:0000050 CL:0000021 ! part of female germ cell @@ -4827,21 +6655,33 @@ relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! Eukaryota [Term] id: GO:0001677 name: formation of translation initiation ternary complex +def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] is_a: GO:0022618 ! protein-RNA complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex relationship: BFO:0000050 GO:0006413 ! part of translational initiation relationship: RO:0002588 GO:0044207 ! results in assembly of translation initiation ternary complex +[Term] +id: GO:0001678 +name: intracellular glucose homeostasis +def: "A homeostatic process involved in the maintenance of a steady state level of glucose within a cell." [GOC:dph, GOC:go_curators, GOC:tb] +is_a: GO:0019725 ! cellular homeostasis +intersection_of: GO:0019725 ! cellular homeostasis +intersection_of: RO:0002332 CHEBI:4167 ! regulates levels of +relationship: RO:0002332 CHEBI:4167 ! regulates levels of + [Term] id: GO:0001696 name: gastric acid secretion +def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] is_a: GO:0022600 ! digestive system process is_a: GO:0046717 ! acid secretion [Term] id: GO:0001700 name: embryonic development via the syncytial blastoderm +def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching relationship: RO:0002160 NCBITaxon:50557 ! Insecta relationship: RO:0002162 NCBITaxon:50557 {all_only="true"} ! Insecta @@ -4849,6 +6689,7 @@ relationship: RO:0002162 NCBITaxon:50557 {all_only="true"} ! Insecta [Term] id: GO:0001701 name: in utero embryonic development +def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development relationship: RO:0002160 NCBITaxon:32525 ! Theria relationship: RO:0002162 NCBITaxon:32525 {all_only="true"} ! Theria @@ -4856,6 +6697,7 @@ relationship: RO:0002162 NCBITaxon:32525 {all_only="true"} ! Theria [Term] id: GO:0001704 name: formation of primary germ layer +def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000923 ! results in formation of germ layer @@ -4865,6 +6707,7 @@ relationship: RO:0002297 UBERON:0000923 ! results in formation of germ layer [Term] id: GO:0001705 name: ectoderm formation +def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000924 ! results in formation of ectoderm @@ -4874,6 +6717,7 @@ relationship: RO:0002297 UBERON:0000924 ! results in formation of ectoderm [Term] id: GO:0001706 name: endoderm formation +def: "The formation of the endoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000925 ! results in formation of endoderm @@ -4883,6 +6727,7 @@ relationship: RO:0002297 UBERON:0000925 ! results in formation of endoderm [Term] id: GO:0001707 name: mesoderm formation +def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000926 ! results in formation of mesoderm @@ -4892,6 +6737,7 @@ relationship: RO:0002297 UBERON:0000926 ! results in formation of mesoderm [Term] id: GO:0001743 name: lens placode formation +def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] is_a: GO:0060788 ! ectodermal placode formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003073 ! results in formation of lens placode @@ -4901,6 +6747,7 @@ relationship: RO:0002297 UBERON:0003073 ! results in formation of lens placode [Term] id: GO:0001745 name: compound eye morphogenesis +def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] is_a: GO:0048592 ! eye morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound eye @@ -4912,6 +6759,7 @@ relationship: RO:0002298 UBERON:0000018 ! results in morphogenesis of compound e [Term] id: GO:0001751 name: compound eye photoreceptor cell differentiation +def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] is_a: GO:0001754 ! eye photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000019 ! results in acquisition of features of compound eye photoreceptor cell @@ -4921,6 +6769,7 @@ relationship: RO:0002315 CL:2000019 ! results in acquisition of features of comp [Term] id: GO:0001754 name: eye photoreceptor cell differentiation +def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000287 ! results in acquisition of features of eye photoreceptor cell @@ -4930,6 +6779,7 @@ relationship: RO:0002315 CL:0000287 ! results in acquisition of features of eye [Term] id: GO:0001755 name: neural crest cell migration +def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] is_a: GO:0090497 ! mesenchymal cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000333 ! results in movement of migratory neural crest cell @@ -4939,6 +6789,8 @@ relationship: RO:0002565 CL:0000333 ! results in movement of migratory neural cr [Term] id: GO:0001756 name: somitogenesis +def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] +xref: Wikipedia:Somitogenesis is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0035282 ! segmentation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis @@ -4951,12 +6803,16 @@ relationship: RO:0002297 UBERON:0002329 ! results in formation of somite [Term] id: GO:0001763 name: morphogenesis of a branching structure +def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001764 name: neuron migration +def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators] +xref: Wikipedia:Neural_development#Neuron_migration +xref: Wikipedia:Neuron_migration is_a: GO:0016477 ! cell migration intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0000540 ! results in movement of neuron @@ -4966,6 +6822,7 @@ relationship: RO:0002565 CL:0000540 ! results in movement of neuron [Term] id: GO:0001767 name: establishment of lymphocyte polarity +def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000542 ! occurs in lymphocyte @@ -4975,6 +6832,7 @@ relationship: BFO:0000066 CL:0000542 ! occurs in lymphocyte [Term] id: GO:0001768 name: establishment of T cell polarity +def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] is_a: GO:0001767 ! establishment of lymphocyte polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell @@ -4984,6 +6842,7 @@ relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0001773 name: myeloid dendritic cell activation +def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell @@ -4992,6 +6851,7 @@ relationship: RO:0004009 CL:0000782 ! has primary input myeloid dendritic cell [Term] id: GO:0001775 name: cell activation +def: "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators] is_a: GO:0009987 ! cellular process is_a: GO:0032501 ! multicellular organismal process relationship: RO:0002160 NCBITaxon:33208 ! Metazoa @@ -5000,6 +6860,8 @@ relationship: RO:0002162 NCBITaxon:33208 {all_only="true"} ! Metazoa [Term] id: GO:0001776 name: leukocyte homeostasis +def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149] +comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells @@ -5011,6 +6873,7 @@ relationship: RO:0012003 CL:0000738 ! acts on population of leukocyte [Term] id: GO:0001777 name: T cell homeostatic proliferation +def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0042098 ! T cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: BFO:0000050 GO:0042592 ! part of homeostatic process @@ -5020,12 +6883,15 @@ relationship: BFO:0000050 GO:0043029 ! part of T cell homeostasis [Term] id: GO:0001816 name: cytokine production +def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0010467 ! gene expression is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001817 name: regulation of cytokine production +def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation @@ -5035,6 +6901,7 @@ relationship: RO:0002211 GO:0001816 ! regulates cytokine production [Term] id: GO:0001818 name: negative regulation of cytokine production +def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051241 ! negative regulation of multicellular organismal process @@ -5045,6 +6912,7 @@ relationship: RO:0002212 GO:0001816 ! negatively regulates cytokine production [Term] id: GO:0001819 name: positive regulation of cytokine production +def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051240 ! positive regulation of multicellular organismal process @@ -5055,6 +6923,7 @@ relationship: RO:0002213 GO:0001816 ! positively regulates cytokine production [Term] id: GO:0001820 name: serotonin secretion +def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149] is_a: GO:0006837 ! serotonin transport is_a: GO:0023061 ! signal release intersection_of: GO:0046903 ! secretion @@ -5063,6 +6932,8 @@ intersection_of: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0001824 name: blastocyst development +def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000358 ! results in development of blastocyst @@ -5074,6 +6945,8 @@ relationship: RO:0002296 UBERON:0000358 ! results in development of blastocyst [Term] id: GO:0001825 name: blastocyst formation +def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0000358 ! results in formation of blastocyst @@ -5083,6 +6956,8 @@ relationship: RO:0002297 UBERON:0000358 ! results in formation of blastocyst [Term] id: GO:0001826 name: inner cell mass cell differentiation +def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000020 ! results in acquisition of features of inner cell mass cell @@ -5092,6 +6967,8 @@ relationship: RO:0002315 CL:2000020 ! results in acquisition of features of inne [Term] id: GO:0001829 name: trophectodermal cell differentiation +def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:1000274 ! results in acquisition of features of trophectodermal cell @@ -5101,6 +6978,8 @@ relationship: RO:0002315 CL:1000274 ! results in acquisition of features of trop [Term] id: GO:0001831 name: trophectodermal cellular morphogenesis +def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. is_a: GO:0000902 ! cell morphogenesis is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -5111,6 +6990,8 @@ relationship: RO:0002298 CL:1000274 ! results in morphogenesis of trophectoderma [Term] id: GO:0001832 name: blastocyst growth +def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. is_a: GO:0048589 ! developmental growth intersection_of: GO:0040007 ! growth intersection_of: RO:0002343 UBERON:0000358 ! results in growth of blastocyst @@ -5120,6 +7001,8 @@ relationship: RO:0002343 UBERON:0000358 ! results in growth of blastocyst [Term] id: GO:0001833 name: inner cell mass cell proliferation +def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell @@ -5129,6 +7012,8 @@ relationship: RO:0012003 CL:2000020 ! acts on population of inner cell mass cell [Term] id: GO:0001834 name: trophectodermal cell proliferation +def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. is_a: GO:0008283 ! cell population proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell @@ -5138,6 +7023,7 @@ relationship: RO:0012003 CL:1000274 ! acts on population of trophectodermal cell [Term] id: GO:0001837 name: epithelial to mesenchymal transition +def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] is_a: GO:0048762 ! mesenchymal cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008019 ! results in acquisition of features of mesenchymal cell @@ -5147,12 +7033,14 @@ relationship: RO:0004009 CL:0000066 ! has primary input epithelial cell [Term] id: GO:0001838 name: embryonic epithelial tube formation +def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0072175 ! epithelial tube formation relationship: BFO:0000050 GO:0016331 ! part of morphogenesis of embryonic epithelium [Term] id: GO:0001839 name: neural plate morphogenesis +def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural plate @@ -5162,6 +7050,7 @@ relationship: RO:0002298 UBERON:0003075 ! results in morphogenesis of neural pla [Term] id: GO:0001840 name: neural plate development +def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003075 ! results in development of neural plate @@ -5171,6 +7060,8 @@ relationship: RO:0002296 UBERON:0003075 ! results in development of neural plate [Term] id: GO:0001841 name: neural tube formation +def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] +xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0001049 ! results in formation of neural tube @@ -5180,6 +7071,7 @@ relationship: RO:0002297 UBERON:0001049 ! results in formation of neural tube [Term] id: GO:0001842 name: neural fold formation +def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold @@ -5191,6 +7083,8 @@ relationship: RO:0002297 UBERON:0005062 ! results in formation of neural fold [Term] id: GO:0001878 name: response to yeast +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091] +comment: defined as response to Saccharomycotina (true yeasts). This excludes fission yeast. is_a: GO:0009620 ! response to fungus intersection_of: GO:0050896 ! response to stimulus intersection_of: RO:0004009 NCBITaxon:147537 ! has primary input Saccharomycotina @@ -5199,6 +7093,7 @@ relationship: RO:0004009 NCBITaxon:147537 ! has primary input Saccharomycotina [Term] id: GO:0001885 name: endothelial cell development +def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000115 ! results in development of endothelial cell @@ -5208,21 +7103,34 @@ relationship: RO:0002296 CL:0000115 ! results in development of endothelial cell [Term] id: GO:0001886 name: endothelial cell morphogenesis +def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell relationship: BFO:0000050 GO:0001885 ! part of endothelial cell development relationship: RO:0002298 CL:0000115 ! results in morphogenesis of endothelial cell +[Term] +id: GO:0001889 +name: liver development +def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] +is_a: GO:0048732 ! gland development +intersection_of: GO:0048856 ! anatomical structure development +intersection_of: RO:0002296 UBERON:0002107 ! results in development of liver +relationship: BFO:0000050 GO:0061008 ! part of hepaticobiliary system development +relationship: RO:0002296 UBERON:0002107 ! results in development of liver + [Term] id: GO:0001894 name: tissue homeostasis +def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete] is_a: GO:0060249 ! anatomical structure homeostasis relationship: BFO:0000050 GO:0048871 ! part of multicellular organismal-level homeostasis [Term] id: GO:0001935 name: endothelial cell proliferation +def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149] is_a: GO:0050673 ! epithelial cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000115 ! acts on population of endothelial cell @@ -5231,6 +7139,7 @@ relationship: RO:0012003 CL:0000115 ! acts on population of endothelial cell [Term] id: GO:0001936 name: regulation of endothelial cell proliferation +def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation @@ -5239,6 +7148,7 @@ relationship: RO:0002211 GO:0001935 ! regulates endothelial cell proliferation [Term] id: GO:0001937 name: negative regulation of endothelial cell proliferation +def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -5248,6 +7158,7 @@ relationship: RO:0002212 GO:0001935 ! negatively regulates endothelial cell prol [Term] id: GO:0001938 name: positive regulation of endothelial cell proliferation +def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -5257,6 +7168,7 @@ relationship: RO:0002213 GO:0001935 ! positively regulates endothelial cell prol [Term] id: GO:0001944 name: vasculature development +def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002049 ! results in development of vasculature @@ -5266,6 +7178,7 @@ relationship: RO:0002296 UBERON:0002049 ! results in development of vasculature [Term] id: GO:0001955 name: blood vessel maturation +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel @@ -5275,11 +7188,15 @@ relationship: RO:0002299 UBERON:0001981 ! results in maturation of blood vessel [Term] id: GO:0001957 name: intramembranous ossification +def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437] +comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. +xref: Wikipedia:Intramembranous_ossification is_a: GO:0036072 ! direct ossification [Term] id: GO:0002009 name: morphogenesis of an epithelium +def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium @@ -5289,6 +7206,7 @@ relationship: RO:0002298 UBERON:0000483 ! results in morphogenesis of epithelium [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet +def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial sheet @@ -5297,11 +7215,13 @@ relationship: RO:0002298 UBERON:0010136 ! results in morphogenesis of epithelial [Term] id: GO:0002027 name: regulation of heart rate +def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] is_a: GO:0008016 ! regulation of heart contraction [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation +def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation @@ -5312,6 +7232,7 @@ relationship: RO:0002213 GO:0007405 ! positively regulates neuroblast proliferat [Term] id: GO:0002053 name: positive regulation of mesenchymal cell proliferation +def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -5321,6 +7242,7 @@ relationship: RO:0002213 GO:0010463 ! positively regulates mesenchymal cell prol [Term] id: GO:0002062 name: chondrocyte differentiation +def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000138 ! results in acquisition of features of chondrocyte @@ -5330,6 +7252,7 @@ relationship: RO:0002315 CL:0000138 ! results in acquisition of features of chon [Term] id: GO:0002063 name: chondrocyte development +def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000138 ! results in development of chondrocyte @@ -5339,6 +7262,7 @@ relationship: RO:0002296 CL:0000138 ! results in development of chondrocyte [Term] id: GO:0002064 name: epithelial cell development +def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000066 ! results in development of epithelial cell @@ -5348,6 +7272,7 @@ relationship: RO:0002296 CL:0000066 ! results in development of epithelial cell [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation +def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000075 ! results in acquisition of features of columnar/cuboidal epithelial cell @@ -5356,6 +7281,7 @@ relationship: RO:0002315 CL:0000075 ! results in acquisition of features of colu [Term] id: GO:0002066 name: columnar/cuboidal epithelial cell development +def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002064 ! epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000075 ! results in development of columnar/cuboidal epithelial cell @@ -5365,6 +7291,7 @@ relationship: RO:0002296 CL:0000075 ! results in development of columnar/cuboida [Term] id: GO:0002067 name: glandular epithelial cell differentiation +def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000150 ! results in acquisition of features of glandular epithelial cell @@ -5373,6 +7300,7 @@ relationship: RO:0002315 CL:0000150 ! results in acquisition of features of glan [Term] id: GO:0002068 name: glandular epithelial cell development +def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development intersection_of: GO:0032502 ! developmental process intersection_of: RO:0002296 CL:0000150 ! results in development of glandular epithelial cell @@ -5382,6 +7310,7 @@ relationship: RO:0002296 CL:0000150 ! results in development of glandular epithe [Term] id: GO:0002069 name: columnar/cuboidal epithelial cell maturation +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal epithelial cell @@ -5391,6 +7320,7 @@ relationship: RO:0002299 CL:0000075 ! results in maturation of columnar/cuboidal [Term] id: GO:0002070 name: epithelial cell maturation +def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048469 ! cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell @@ -5400,6 +7330,7 @@ relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell [Term] id: GO:0002071 name: glandular epithelial cell maturation +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: RO:0002299 CL:0000150 ! results in maturation of glandular epithelial cell @@ -5409,6 +7340,7 @@ relationship: RO:0002299 CL:0000150 ! results in maturation of glandular epithel [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development +def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup @@ -5418,6 +7350,7 @@ relationship: RO:0002298 UBERON:0003072 ! results in morphogenesis of optic cup [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation +def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045995 ! regulation of embryonic development @@ -5429,6 +7362,7 @@ relationship: RO:0002212 GO:0060563 ! negatively regulates neuroepithelial cell [Term] id: GO:0002087 name: regulation of respiratory gaseous exchange by nervous system process +def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] is_a: GO:0044065 ! regulation of respiratory system process is_a: GO:0050877 ! nervous system process intersection_of: GO:0050877 ! nervous system process @@ -5437,6 +7371,7 @@ intersection_of: RO:0002211 GO:0007585 ! regulates respiratory gaseous exchange [Term] id: GO:0002088 name: lens development in camera-type eye +def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000965 ! results in development of lens of camera-type eye @@ -5446,6 +7381,7 @@ relationship: RO:0002296 UBERON:0000965 ! results in development of lens of came [Term] id: GO:0002089 name: lens morphogenesis in camera-type eye +def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of camera-type eye @@ -5456,6 +7392,7 @@ relationship: RO:0002298 UBERON:0000965 ! results in morphogenesis of lens of ca [Term] id: GO:0002158 name: osteoclast proliferation +def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd] is_a: GO:0070661 ! leukocyte proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000092 ! acts on population of osteoclast @@ -5464,6 +7401,7 @@ relationship: RO:0012003 CL:0000092 ! acts on population of osteoclast [Term] id: GO:0002213 name: defense response to insect +def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] is_a: GO:0006952 ! defense response intersection_of: GO:0006952 ! defense response intersection_of: RO:0004009 NCBITaxon:50557 ! has primary input Insecta @@ -5472,6 +7410,7 @@ relationship: RO:0004009 NCBITaxon:50557 ! has primary input Insecta [Term] id: GO:0002232 name: leukocyte chemotaxis involved in inflammatory response +def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002523 ! leukocyte migration involved in inflammatory response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis @@ -5480,6 +7419,7 @@ intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002233 name: leukocyte chemotaxis involved in immune response +def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002522 ! leukocyte migration involved in immune response is_a: GO:0030595 ! leukocyte chemotaxis intersection_of: GO:0030595 ! leukocyte chemotaxis @@ -5488,6 +7428,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002244 name: hematopoietic progenitor cell differentiation +def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0008001 ! results in acquisition of features of hematopoietic precursor cell @@ -5497,18 +7438,28 @@ relationship: RO:0002315 CL:0008001 ! results in acquisition of features of hema [Term] id: GO:0002250 name: adaptive immune response +def: "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, ISBN:0781735149] +xref: Wikipedia:Adaptive_immune_system is_a: GO:0006955 ! immune response relationship: RO:0002160 NCBITaxon:33208 ! Metazoa relationship: RO:0002162 NCBITaxon:33208 {all_only="true"} ! Metazoa +[Term] +id: GO:0002251 +name: organ or tissue specific immune response +def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal] +is_a: GO:0006955 ! immune response + [Term] id: GO:0002252 name: immune effector process +def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002376 ! immune system process [Term] id: GO:0002260 name: lymphocyte homeostasis +def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] is_a: GO:0001776 ! leukocyte homeostasis intersection_of: GO:0048872 ! homeostasis of number of cells intersection_of: RO:0012003 CL:0000542 ! acts on population of lymphocyte @@ -5517,6 +7468,7 @@ relationship: RO:0012003 CL:0000542 ! acts on population of lymphocyte [Term] id: GO:0002262 name: myeloid cell homeostasis +def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells intersection_of: GO:0048872 ! homeostasis of number of cells @@ -5526,6 +7478,7 @@ relationship: RO:0012003 CL:0000763 ! acts on population of myeloid cell [Term] id: GO:0002263 name: cell activation involved in immune response +def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0001775 ! cell activation is_a: GO:0002252 ! immune effector process intersection_of: GO:0001775 ! cell activation @@ -5535,6 +7488,7 @@ relationship: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002264 name: endothelial cell activation involved in immune response +def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0042118 ! endothelial cell activation intersection_of: GO:0042118 ! endothelial cell activation @@ -5543,6 +7497,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002269 name: leukocyte activation involved in inflammatory response +def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response @@ -5551,6 +7506,7 @@ relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002274 name: myeloid leukocyte activation +def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149] is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0001775 ! cell activation intersection_of: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte @@ -5559,12 +7515,14 @@ relationship: RO:0004009 CL:0000766 ! has primary input myeloid leukocyte [Term] id: GO:0002275 name: myeloid cell activation involved in immune response +def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002277 name: myeloid dendritic cell activation involved in immune response +def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002275 ! myeloid cell activation involved in immune response intersection_of: GO:0001773 ! myeloid dendritic cell activation @@ -5573,6 +7531,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002280 name: monocyte activation involved in immune response +def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042117 ! monocyte activation intersection_of: GO:0042117 ! monocyte activation @@ -5581,6 +7540,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002281 name: macrophage activation involved in immune response +def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0042116 ! macrophage activation intersection_of: GO:0042116 ! macrophage activation @@ -5590,6 +7550,7 @@ relationship: BFO:0000050 GO:0002275 ! part of myeloid cell activation involved [Term] id: GO:0002284 name: myeloid dendritic cell differentiation involved in immune response +def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response is_a: GO:0043011 ! myeloid dendritic cell differentiation intersection_of: GO:0043011 ! myeloid dendritic cell differentiation @@ -5598,6 +7559,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002285 name: lymphocyte activation involved in immune response +def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation intersection_of: GO:0046649 ! lymphocyte activation @@ -5606,6 +7568,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002286 name: T cell activation involved in immune response +def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042110 ! T cell activation intersection_of: GO:0042110 ! T cell activation @@ -5614,6 +7577,8 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002292 name: T cell differentiation involved in immune response +def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0030217 ! T cell differentiation intersection_of: GO:0030217 ! T cell differentiation @@ -5622,6 +7587,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002309 name: T cell proliferation involved in immune response +def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0042098 ! T cell proliferation intersection_of: GO:0042098 ! T cell proliferation @@ -5630,6 +7596,7 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002318 name: myeloid progenitor cell differentiation +def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000839 ! results in acquisition of features of myeloid lineage restricted progenitor cell @@ -5638,6 +7605,7 @@ relationship: RO:0002315 CL:0000839 ! results in acquisition of features of myel [Term] id: GO:0002320 name: lymphoid progenitor cell differentiation +def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000838 ! results in acquisition of features of lymphoid lineage restricted progenitor cell @@ -5646,11 +7614,13 @@ relationship: RO:0002315 CL:0000838 ! results in acquisition of features of lymp [Term] id: GO:0002351 name: serotonin production involved in inflammatory response +def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002366 name: leukocyte activation involved in immune response +def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation intersection_of: GO:0045321 ! leukocyte activation @@ -5659,6 +7629,8 @@ intersection_of: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002367 name: cytokine production involved in immune response +def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response intersection_of: GO:0001816 ! cytokine production @@ -5668,6 +7640,8 @@ relationship: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002369 name: T cell cytokine production +def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002456 ! T cell mediated immunity intersection_of: GO:0001816 ! cytokine production @@ -5676,6 +7650,8 @@ intersection_of: RO:0002608 CL:0000084 ! process has causal agent T cell [Term] id: GO:0002371 name: dendritic cell cytokine production +def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0001816 ! cytokine production @@ -5685,6 +7661,8 @@ relationship: RO:0002608 CL:0000451 ! process has causal agent dendritic cell [Term] id: GO:0002372 name: myeloid dendritic cell cytokine production +def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0002371 ! dendritic cell cytokine production is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0061082 ! myeloid leukocyte cytokine production @@ -5695,11 +7673,26 @@ relationship: RO:0002608 CL:0000782 ! process has causal agent myeloid dendritic [Term] id: GO:0002376 name: immune system process +def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] +comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). +xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process +[Term] +id: GO:0002384 +name: hepatic immune response +def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +is_a: GO:0002251 ! organ or tissue specific immune response +intersection_of: GO:0006955 ! immune response +intersection_of: BFO:0000066 UBERON:0002107 ! occurs in liver +relationship: BFO:0000066 UBERON:0002107 ! occurs in liver +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002162 NCBITaxon:7742 {all_only="true"} ! Vertebrata + [Term] id: GO:0002396 name: MHC protein complex assembly +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] is_a: GO:0065003 ! protein-containing complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex @@ -5708,6 +7701,7 @@ relationship: RO:0002588 GO:0042611 ! results in assembly of MHC protein complex [Term] id: GO:0002399 name: MHC class II protein complex assembly +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly intersection_of: GO:0022607 ! cellular component assembly intersection_of: RO:0002588 GO:0042613 ! results in assembly of MHC class II protein complex @@ -5716,6 +7710,7 @@ relationship: RO:0002588 GO:0042613 ! results in assembly of MHC class II protei [Term] id: GO:0002407 name: dendritic cell chemotaxis +def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0036336 ! dendritic cell migration intersection_of: GO:0006935 ! chemotaxis @@ -5724,6 +7719,7 @@ intersection_of: RO:0002565 CL:0000451 ! results in movement of dendritic cell [Term] id: GO:0002408 name: myeloid dendritic cell chemotaxis +def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0002407 ! dendritic cell chemotaxis is_a: GO:0097529 ! myeloid leukocyte migration intersection_of: GO:0006935 ! chemotaxis @@ -5733,12 +7729,15 @@ relationship: RO:0002565 CL:0000782 ! results in movement of myeloid dendritic c [Term] id: GO:0002440 name: production of molecular mediator of immune response +def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. is_a: GO:0002376 ! immune system process is_a: GO:0010467 ! gene expression [Term] id: GO:0002442 name: serotonin secretion involved in inflammatory response +def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0001820 ! serotonin secretion intersection_of: GO:0001820 ! serotonin secretion intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response @@ -5747,6 +7746,7 @@ relationship: BFO:0000050 GO:0002351 ! part of serotonin production involved in [Term] id: GO:0002443 name: leukocyte mediated immunity +def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002252 ! immune effector process intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000738 ! process has causal agent leukocyte @@ -5757,6 +7757,7 @@ relationship: RO:0002608 CL:0000738 ! process has causal agent leukocyte [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity +def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte @@ -5765,6 +7766,7 @@ relationship: RO:0002608 CL:0000766 ! process has causal agent myeloid leukocyte [Term] id: GO:0002449 name: lymphocyte mediated immunity +def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002443 ! leukocyte mediated immunity intersection_of: GO:0002376 ! immune system process intersection_of: RO:0002608 CL:0000542 ! process has causal agent lymphocyte @@ -5773,6 +7775,7 @@ relationship: RO:0002608 CL:0000542 ! process has causal agent lymphocyte [Term] id: GO:0002456 name: T cell mediated immunity +def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, ISBN:0781735149] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0002376 ! immune system process @@ -5782,6 +7785,7 @@ relationship: RO:0002608 CL:0000084 ! process has causal agent T cell [Term] id: GO:0002457 name: T cell antigen processing and presentation +def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000084 ! occurs in T cell @@ -5791,11 +7795,13 @@ relationship: BFO:0000066 CL:0000084 ! occurs in T cell [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002468 name: dendritic cell antigen processing and presentation +def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000451 ! occurs in dendritic cell @@ -5804,6 +7810,7 @@ relationship: BFO:0000066 CL:0000451 ! occurs in dendritic cell [Term] id: GO:0002469 name: myeloid dendritic cell antigen processing and presentation +def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell @@ -5812,6 +7819,7 @@ relationship: BFO:0000066 CL:0000782 ! occurs in myeloid dendritic cell [Term] id: GO:0002471 name: monocyte antigen processing and presentation +def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000576 ! occurs in monocyte @@ -5820,6 +7828,7 @@ relationship: BFO:0000066 CL:0000576 ! occurs in monocyte [Term] id: GO:0002472 name: macrophage antigen processing and presentation +def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation intersection_of: GO:0019882 ! antigen processing and presentation intersection_of: BFO:0000066 CL:0000235 ! occurs in macrophage @@ -5828,11 +7837,13 @@ relationship: BFO:0000066 CL:0000235 ! occurs in macrophage [Term] id: GO:0002504 name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002520 name: immune system development +def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development intersection_of: GO:0048856 ! anatomical structure development @@ -5842,6 +7853,7 @@ relationship: RO:0002296 UBERON:0002405 ! results in development of immune syste [Term] id: GO:0002521 name: leukocyte differentiation +def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000738 ! results in acquisition of features of leukocyte @@ -5851,6 +7863,7 @@ relationship: RO:0002315 CL:0000738 ! results in acquisition of features of leuk [Term] id: GO:0002522 name: leukocyte migration involved in immune response +def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] is_a: GO:0002252 ! immune effector process is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration @@ -5860,6 +7873,7 @@ relationship: BFO:0000050 GO:0006955 ! part of immune response [Term] id: GO:0002523 name: leukocyte migration involved in inflammatory response +def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] is_a: GO:0050900 ! leukocyte migration intersection_of: GO:0050900 ! leukocyte migration intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response @@ -5868,12 +7882,14 @@ relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002532 name: production of molecular mediator involved in inflammatory response +def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] is_a: GO:0032501 ! multicellular organismal process relationship: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002534 name: cytokine production involved in inflammatory response +def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] is_a: GO:0001816 ! cytokine production is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response intersection_of: GO:0001816 ! cytokine production @@ -5882,6 +7898,7 @@ intersection_of: BFO:0000050 GO:0006954 ! part of inflammatory response [Term] id: GO:0002548 name: monocyte chemotaxis +def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0071674 ! mononuclear cell migration is_a: GO:0097529 ! myeloid leukocyte migration @@ -5892,6 +7909,7 @@ relationship: RO:0002565 CL:0000576 ! results in movement of monocyte [Term] id: GO:0002572 name: pro-T cell differentiation +def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149] is_a: GO:0002320 ! lymphoid progenitor cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0000827 ! results in acquisition of features of pro-T cell @@ -5901,6 +7919,7 @@ relationship: RO:0002315 CL:0000827 ! results in acquisition of features of pro- [Term] id: GO:0002573 name: myeloid leukocyte differentiation +def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation intersection_of: GO:0030154 ! cell differentiation @@ -5910,6 +7929,7 @@ relationship: RO:0002315 CL:0000766 ! results in acquisition of features of myel [Term] id: GO:0002577 name: regulation of antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0019882 ! regulates antigen processing and presentation @@ -5918,6 +7938,7 @@ relationship: RO:0002211 GO:0019882 ! regulates antigen processing and presentat [Term] id: GO:0002578 name: negative regulation of antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002683 ! negative regulation of immune system process intersection_of: GO:0065007 ! biological regulation @@ -5927,6 +7948,7 @@ relationship: RO:0002212 GO:0019882 ! negatively regulates antigen processing an [Term] id: GO:0002579 name: positive regulation of antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002684 ! positive regulation of immune system process intersection_of: GO:0065007 ! biological regulation @@ -5936,6 +7958,7 @@ relationship: RO:0002213 GO:0019882 ! positively regulates antigen processing an [Term] id: GO:0002580 name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002504 ! regulates antigen processing and presentation of peptide or polysaccharide antigen via MHC class II @@ -5944,6 +7967,7 @@ relationship: RO:0002211 GO:0002504 ! regulates antigen processing and presentat [Term] id: GO:0002581 name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation @@ -5953,6 +7977,7 @@ relationship: RO:0002212 GO:0002504 ! negatively regulates antigen processing an [Term] id: GO:0002582 name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation @@ -5962,6 +7987,7 @@ relationship: RO:0002213 GO:0002504 ! positively regulates antigen processing an [Term] id: GO:0002604 name: regulation of dendritic cell antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002468 ! regulates dendritic cell antigen processing and presentation @@ -5970,6 +7996,7 @@ relationship: RO:0002211 GO:0002468 ! regulates dendritic cell antigen processin [Term] id: GO:0002605 name: negative regulation of dendritic cell antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -5979,6 +8006,7 @@ relationship: RO:0002212 GO:0002468 ! negatively regulates dendritic cell antige [Term] id: GO:0002606 name: positive regulation of dendritic cell antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -5988,6 +8016,7 @@ relationship: RO:0002213 GO:0002468 ! positively regulates dendritic cell antige [Term] id: GO:0002607 name: regulation of myeloid dendritic cell antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002469 ! regulates myeloid dendritic cell antigen processing and presentation @@ -5996,6 +8025,7 @@ relationship: RO:0002211 GO:0002469 ! regulates myeloid dendritic cell antigen p [Term] id: GO:0002608 name: negative regulation of myeloid dendritic cell antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6005,6 +8035,7 @@ relationship: RO:0002212 GO:0002469 ! negatively regulates myeloid dendritic cel [Term] id: GO:0002609 name: positive regulation of myeloid dendritic cell antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6014,6 +8045,7 @@ relationship: RO:0002213 GO:0002469 ! positively regulates myeloid dendritic cel [Term] id: GO:0002613 name: regulation of monocyte antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002471 ! regulates monocyte antigen processing and presentation @@ -6022,6 +8054,7 @@ relationship: RO:0002211 GO:0002471 ! regulates monocyte antigen processing and [Term] id: GO:0002614 name: negative regulation of monocyte antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6031,6 +8064,7 @@ relationship: RO:0002212 GO:0002471 ! negatively regulates monocyte antigen proc [Term] id: GO:0002615 name: positive regulation of monocyte antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6040,6 +8074,7 @@ relationship: RO:0002213 GO:0002471 ! positively regulates monocyte antigen proc [Term] id: GO:0002616 name: regulation of macrophage antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002472 ! regulates macrophage antigen processing and presentation @@ -6048,6 +8083,7 @@ relationship: RO:0002211 GO:0002472 ! regulates macrophage antigen processing an [Term] id: GO:0002617 name: negative regulation of macrophage antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6057,6 +8093,7 @@ relationship: RO:0002212 GO:0002472 ! negatively regulates macrophage antigen pr [Term] id: GO:0002618 name: positive regulation of macrophage antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0065007 ! biological regulation @@ -6066,6 +8103,7 @@ relationship: RO:0002213 GO:0002472 ! positively regulates macrophage antigen pr [Term] id: GO:0002625 name: regulation of T cell antigen processing and presentation +def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6075,6 +8113,7 @@ relationship: RO:0002211 GO:0002457 ! regulates T cell antigen processing and pr [Term] id: GO:0002626 name: negative regulation of T cell antigen processing and presentation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002710 ! negative regulation of T cell mediated immunity @@ -6085,6 +8124,7 @@ relationship: RO:0002212 GO:0002457 ! negatively regulates T cell antigen proces [Term] id: GO:0002627 name: positive regulation of T cell antigen processing and presentation +def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002711 ! positive regulation of T cell mediated immunity @@ -6095,6 +8135,7 @@ relationship: RO:0002213 GO:0002457 ! positively regulates T cell antigen proces [Term] id: GO:0002682 name: regulation of immune system process +def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002376 ! regulates immune system process @@ -6103,6 +8144,7 @@ relationship: RO:0002211 GO:0002376 ! regulates immune system process [Term] id: GO:0002683 name: negative regulation of immune system process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation @@ -6112,6 +8154,7 @@ relationship: RO:0002212 GO:0002376 ! negatively regulates immune system process [Term] id: GO:0002684 name: positive regulation of immune system process +def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation @@ -6121,6 +8164,7 @@ relationship: RO:0002213 GO:0002376 ! positively regulates immune system process [Term] id: GO:0002685 name: regulation of leukocyte migration +def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation @@ -6130,6 +8174,7 @@ relationship: RO:0002211 GO:0050900 ! regulates leukocyte migration [Term] id: GO:0002686 name: negative regulation of leukocyte migration +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030336 ! negative regulation of cell migration @@ -6140,6 +8185,7 @@ relationship: RO:0002212 GO:0050900 ! negatively regulates leukocyte migration [Term] id: GO:0002687 name: positive regulation of leukocyte migration +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030335 ! positive regulation of cell migration @@ -6150,6 +8196,7 @@ relationship: RO:0002213 GO:0050900 ! positively regulates leukocyte migration [Term] id: GO:0002688 name: regulation of leukocyte chemotaxis +def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation @@ -6159,6 +8206,7 @@ relationship: RO:0002211 GO:0030595 ! regulates leukocyte chemotaxis [Term] id: GO:0002689 name: negative regulation of leukocyte chemotaxis +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050922 ! negative regulation of chemotaxis @@ -6169,6 +8217,7 @@ relationship: RO:0002212 GO:0030595 ! negatively regulates leukocyte chemotaxis [Term] id: GO:0002690 name: positive regulation of leukocyte chemotaxis +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050921 ! positive regulation of chemotaxis @@ -6179,6 +8228,7 @@ relationship: RO:0002213 GO:0030595 ! positively regulates leukocyte chemotaxis [Term] id: GO:0002694 name: regulation of leukocyte activation +def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation @@ -6188,6 +8238,7 @@ relationship: RO:0002211 GO:0045321 ! regulates leukocyte activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation @@ -6198,6 +8249,7 @@ relationship: RO:0002212 GO:0045321 ! negatively regulates leukocyte activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation @@ -6208,6 +8260,7 @@ relationship: RO:0002213 GO:0045321 ! positively regulates leukocyte activation [Term] id: GO:0002697 name: regulation of immune effector process +def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002252 ! regulates immune effector process @@ -6216,6 +8269,7 @@ relationship: RO:0002211 GO:0002252 ! regulates immune effector process [Term] id: GO:0002698 name: negative regulation of immune effector process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation @@ -6225,6 +8279,7 @@ relationship: RO:0002212 GO:0002252 ! negatively regulates immune effector proce [Term] id: GO:0002699 name: positive regulation of immune effector process +def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation @@ -6234,6 +8289,7 @@ relationship: RO:0002213 GO:0002252 ! positively regulates immune effector proce [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response +def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0010468 ! regulation of gene expression intersection_of: GO:0065007 ! biological regulation @@ -6243,6 +8299,7 @@ relationship: RO:0002211 GO:0002440 ! regulates production of molecular mediator [Term] id: GO:0002701 name: negative regulation of production of molecular mediator of immune response +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0010629 ! negative regulation of gene expression @@ -6253,6 +8310,7 @@ relationship: RO:0002212 GO:0002440 ! negatively regulates production of molecul [Term] id: GO:0002702 name: positive regulation of production of molecular mediator of immune response +def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0010628 ! positive regulation of gene expression @@ -6263,6 +8321,7 @@ relationship: RO:0002213 GO:0002440 ! positively regulates production of molecul [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity +def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity @@ -6271,6 +8330,7 @@ relationship: RO:0002211 GO:0002443 ! regulates leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6280,6 +8340,7 @@ relationship: RO:0002212 GO:0002443 ! negatively regulates leukocyte mediated im [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6289,6 +8350,7 @@ relationship: RO:0002213 GO:0002443 ! positively regulates leukocyte mediated im [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity +def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002449 ! regulates lymphocyte mediated immunity @@ -6297,6 +8359,7 @@ relationship: RO:0002211 GO:0002449 ! regulates lymphocyte mediated immunity [Term] id: GO:0002707 name: negative regulation of lymphocyte mediated immunity +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6306,6 +8369,7 @@ relationship: RO:0002212 GO:0002449 ! negatively regulates lymphocyte mediated i [Term] id: GO:0002708 name: positive regulation of lymphocyte mediated immunity +def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6315,6 +8379,7 @@ relationship: RO:0002213 GO:0002449 ! positively regulates lymphocyte mediated i [Term] id: GO:0002709 name: regulation of T cell mediated immunity +def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation @@ -6324,6 +8389,7 @@ relationship: RO:0002211 GO:0002456 ! regulates T cell mediated immunity [Term] id: GO:0002710 name: negative regulation of T cell mediated immunity +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains @@ -6334,6 +8400,7 @@ relationship: RO:0002212 GO:0002456 ! negatively regulates T cell mediated immun [Term] id: GO:0002711 name: positive regulation of T cell mediated immunity +def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains @@ -6344,6 +8411,7 @@ relationship: RO:0002213 GO:0002456 ! positively regulates T cell mediated immun [Term] id: GO:0002718 name: regulation of cytokine production involved in immune response +def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation @@ -6353,6 +8421,7 @@ relationship: RO:0002211 GO:0002367 ! regulates cytokine production involved in [Term] id: GO:0002719 name: negative regulation of cytokine production involved in immune response +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response @@ -6363,6 +8432,7 @@ relationship: RO:0002212 GO:0002367 ! negatively regulates cytokine production i [Term] id: GO:0002720 name: positive regulation of cytokine production involved in immune response +def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response @@ -6373,6 +8443,7 @@ relationship: RO:0002213 GO:0002367 ! positively regulates cytokine production i [Term] id: GO:0002724 name: regulation of T cell cytokine production +def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation @@ -6382,6 +8453,7 @@ relationship: RO:0002211 GO:0002369 ! regulates T cell cytokine production [Term] id: GO:0002725 name: negative regulation of T cell cytokine production +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production @@ -6392,6 +8464,7 @@ relationship: RO:0002212 GO:0002369 ! negatively regulates T cell cytokine produ [Term] id: GO:0002726 name: positive regulation of T cell cytokine production +def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production @@ -6402,6 +8475,7 @@ relationship: RO:0002213 GO:0002369 ! positively regulates T cell cytokine produ [Term] id: GO:0002730 name: regulation of dendritic cell cytokine production +def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation @@ -6411,6 +8485,7 @@ relationship: RO:0002211 GO:0002371 ! regulates dendritic cell cytokine producti [Term] id: GO:0002731 name: negative regulation of dendritic cell cytokine production +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production @@ -6421,6 +8496,7 @@ relationship: RO:0002212 GO:0002371 ! negatively regulates dendritic cell cytoki [Term] id: GO:0002732 name: positive regulation of dendritic cell cytokine production +def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production @@ -6431,6 +8507,7 @@ relationship: RO:0002213 GO:0002371 ! positively regulates dendritic cell cytoki [Term] id: GO:0002733 name: regulation of myeloid dendritic cell cytokine production +def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6440,6 +8517,7 @@ relationship: RO:0002211 GO:0002372 ! regulates myeloid dendritic cell cytokine [Term] id: GO:0002734 name: negative regulation of myeloid dendritic cell cytokine production +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity @@ -6450,6 +8528,7 @@ relationship: RO:0002212 GO:0002372 ! negatively regulates myeloid dendritic cel [Term] id: GO:0002735 name: positive regulation of myeloid dendritic cell cytokine production +def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity @@ -6461,6 +8540,7 @@ relationship: RO:0002213 GO:0002372 ! positively regulates myeloid dendritic cel [Term] id: GO:0002761 name: regulation of myeloid leukocyte differentiation +def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation @@ -6470,6 +8550,7 @@ relationship: RO:0002211 GO:0002573 ! regulates myeloid leukocyte differentiatio [Term] id: GO:0002762 name: negative regulation of myeloid leukocyte differentiation +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:1902106 ! negative regulation of leukocyte differentiation @@ -6480,6 +8561,7 @@ relationship: RO:0002212 GO:0002573 ! negatively regulates myeloid leukocyte dif [Term] id: GO:0002763 name: positive regulation of myeloid leukocyte differentiation +def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:1902107 ! positive regulation of leukocyte differentiation @@ -6490,6 +8572,7 @@ relationship: RO:0002213 GO:0002573 ! positively regulates myeloid leukocyte dif [Term] id: GO:0002790 name: peptide secretion +def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion intersection_of: GO:0046903 ! secretion @@ -6498,6 +8581,7 @@ intersection_of: RO:0004009 CHEBI:60466 ! has primary input [Term] id: GO:0002791 name: regulation of peptide secretion +def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0065007 ! biological regulation @@ -6507,6 +8591,7 @@ relationship: RO:0002211 GO:0002790 ! regulates peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion intersection_of: GO:0065007 ! biological regulation @@ -6516,6 +8601,7 @@ relationship: RO:0002212 GO:0002790 ! negatively regulates peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion +def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion intersection_of: GO:0065007 ! biological regulation @@ -6525,6 +8611,7 @@ relationship: RO:0002213 GO:0002790 ! positively regulates peptide secretion [Term] id: GO:0002819 name: regulation of adaptive immune response +def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002250 ! regulates adaptive immune response @@ -6533,6 +8620,7 @@ relationship: RO:0002211 GO:0002250 ! regulates adaptive immune response [Term] id: GO:0002820 name: negative regulation of adaptive immune response +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation @@ -6542,6 +8630,7 @@ relationship: RO:0002212 GO:0002250 ! negatively regulates adaptive immune respo [Term] id: GO:0002821 name: positive regulation of adaptive immune response +def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation @@ -6551,6 +8640,7 @@ relationship: RO:0002213 GO:0002250 ! positively regulates adaptive immune respo [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002819 ! regulation of adaptive immune response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002460 ! regulates adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains @@ -6561,6 +8651,7 @@ relationship: RO:0002211 GO:0002460 ! regulates adaptive immune response based o [Term] id: GO:0002823 name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation @@ -6570,6 +8661,7 @@ relationship: RO:0002212 GO:0002460 ! negatively regulates adaptive immune respo [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation @@ -6579,6 +8671,8 @@ relationship: RO:0002213 GO:0002460 ! positively regulates adaptive immune respo [Term] id: GO:0002831 name: regulation of response to biotic stimulus +def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009607 ! regulates response to biotic stimulus @@ -6587,6 +8681,8 @@ relationship: RO:0002211 GO:0009607 ! regulates response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation @@ -6596,6 +8692,8 @@ relationship: RO:0002212 GO:0009607 ! negatively regulates response to biotic st [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus +def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation @@ -6605,6 +8703,7 @@ relationship: RO:0002213 GO:0009607 ! positively regulates response to biotic st [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity +def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immunity @@ -6613,6 +8712,7 @@ relationship: RO:0002211 GO:0002444 ! regulates myeloid leukocyte mediated immun [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6622,6 +8722,7 @@ relationship: RO:0002212 GO:0002444 ! negatively regulates myeloid leukocyte med [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity +def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation @@ -6631,6 +8732,7 @@ relationship: RO:0002213 GO:0002444 ! positively regulates myeloid leukocyte med [Term] id: GO:0002932 name: tendon sheath development +def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0000304 ! results in development of tendon sheath @@ -6640,11 +8742,13 @@ relationship: RO:0002296 UBERON:0000304 ! results in development of tendon sheat [Term] id: GO:0003002 name: regionalization +def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0003006 name: developmental process involved in reproduction +def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process intersection_of: GO:0022414 ! reproductive process @@ -6653,6 +8757,7 @@ intersection_of: GO:0032502 ! developmental process [Term] id: GO:0003007 name: heart morphogenesis +def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] is_a: GO:0009887 ! animal organ morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary circulatory organ @@ -6662,11 +8767,13 @@ relationship: RO:0002298 UBERON:0007100 ! results in morphogenesis of primary ci [Term] id: GO:0003008 name: system process +def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003009 name: skeletal muscle contraction +def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0006941 ! striated muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue @@ -6676,33 +8783,46 @@ relationship: BFO:0000066 UBERON:0001134 ! occurs in skeletal muscle tissue [Term] id: GO:0003012 name: muscle system process +def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] is_a: GO:0003008 ! system process [Term] id: GO:0003013 name: circulatory system process +def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] +xref: Wikipedia:Circulatory_system +is_a: GO:0003008 ! system process + +[Term] +id: GO:0003014 +name: renal system process +def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process +def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003016 name: respiratory system process +def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] is_a: GO:0003008 ! system process relationship: BFO:0000050 GO:0007585 ! part of respiratory gaseous exchange by respiratory system [Term] id: GO:0003032 name: detection of oxygen +def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0003131 name: mesodermal-endodermal cell signaling +def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000222 ! has start location mesodermal cell @@ -6713,6 +8833,7 @@ relationship: RO:0002232 CL:0000223 ! has end location endodermal cell [Term] id: GO:0003133 name: endodermal-mesodermal cell signaling +def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] is_a: GO:0007267 ! cell-cell signaling intersection_of: GO:0007267 ! cell-cell signaling intersection_of: RO:0002231 CL:0000223 ! has start location endodermal cell @@ -6723,6 +8844,7 @@ relationship: RO:0002232 CL:0000222 ! has end location mesodermal cell [Term] id: GO:0003142 name: cardiogenic plate morphogenesis +def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogenic plate @@ -6732,6 +8854,7 @@ relationship: RO:0002298 UBERON:0004139 ! results in morphogenesis of cardiogeni [Term] id: GO:0003143 name: embryonic heart tube morphogenesis +def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -6744,6 +8867,7 @@ relationship: RO:0002298 UBERON:0004141 ! results in morphogenesis of heart tube [Term] id: GO:0003144 name: embryonic heart tube formation +def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0001838 ! embryonic epithelial tube formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004141 ! results in formation of heart tube @@ -6753,11 +8877,13 @@ relationship: RO:0002297 UBERON:0004141 ! results in formation of heart tube [Term] id: GO:0003145 name: embryonic heart tube formation via epithelial folding +def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] is_a: GO:0003144 ! embryonic heart tube formation [Term] id: GO:0003147 name: neural crest cell migration involved in heart formation +def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060974 ! cell migration involved in heart formation intersection_of: GO:0001755 ! neural crest cell migration @@ -6767,6 +8893,7 @@ relationship: BFO:0000050 GO:0061308 ! part of cardiac neural crest cell develop [Term] id: GO:0003148 name: outflow tract septum morphogenesis +def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] is_a: GO:0060411 ! cardiac septum morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tract septum @@ -6776,6 +8903,7 @@ relationship: RO:0002298 UBERON:0004142 ! results in morphogenesis of outflow tr [Term] id: GO:0003149 name: membranous septum morphogenesis +def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventricular septum membranous part @@ -6785,6 +8913,7 @@ relationship: RO:0002298 UBERON:0004666 ! results in morphogenesis of interventr [Term] id: GO:0003150 name: muscular septum morphogenesis +def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventricular septum muscular part @@ -6794,6 +8923,7 @@ relationship: RO:0002298 UBERON:0004667 ! results in morphogenesis of interventr [Term] id: GO:0003151 name: outflow tract morphogenesis +def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tract @@ -6803,6 +8933,7 @@ relationship: RO:0002298 UBERON:0004145 ! results in morphogenesis of outflow tr [Term] id: GO:0003152 name: morphogenesis of an epithelial fold involved in embryonic heart tube formation +def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold intersection_of: GO:0060571 ! morphogenesis of an epithelial fold @@ -6812,6 +8943,7 @@ relationship: BFO:0000050 GO:0003145 ! part of embryonic heart tube formation vi [Term] id: GO:0003156 name: regulation of animal organ formation +def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048645 ! regulates animal organ formation @@ -6820,6 +8952,7 @@ relationship: RO:0002211 GO:0048645 ! regulates animal organ formation [Term] id: GO:0003157 name: endocardium development +def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002165 ! results in development of endocardium @@ -6829,6 +8962,7 @@ relationship: RO:0002296 UBERON:0002165 ! results in development of endocardium [Term] id: GO:0003158 name: endothelium development +def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0001986 ! results in development of endothelium @@ -6837,6 +8971,7 @@ relationship: RO:0002296 UBERON:0001986 ! results in development of endothelium [Term] id: GO:0003159 name: morphogenesis of an endothelium +def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0001986 ! results in morphogenesis of endothelium @@ -6846,6 +8981,7 @@ relationship: RO:0002298 UBERON:0001986 ! results in morphogenesis of endotheliu [Term] id: GO:0003160 name: endocardium morphogenesis +def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardium @@ -6855,6 +8991,7 @@ relationship: RO:0002298 UBERON:0002165 ! results in morphogenesis of endocardiu [Term] id: GO:0003161 name: cardiac conduction system development +def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002350 ! results in development of conducting system of heart @@ -6863,6 +9000,7 @@ relationship: RO:0002296 UBERON:0002350 ! results in development of conducting s [Term] id: GO:0003162 name: atrioventricular node development +def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002352 ! results in development of atrioventricular node @@ -6872,6 +9010,7 @@ relationship: RO:0002296 UBERON:0002352 ! results in development of atrioventric [Term] id: GO:0003163 name: sinoatrial node development +def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] is_a: GO:0003228 ! atrial cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002351 ! results in development of sinoatrial node @@ -6881,6 +9020,7 @@ relationship: RO:0002296 UBERON:0002351 ! results in development of sinoatrial n [Term] id: GO:0003164 name: His-Purkinje system development +def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje system @@ -6890,6 +9030,7 @@ relationship: RO:0002296 UBERON:0004146 ! results in development of His-Purkinje [Term] id: GO:0003165 name: Purkinje myocyte development +def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002354 ! results in development of cardiac Purkinje fiber @@ -6899,6 +9040,7 @@ relationship: RO:0002296 UBERON:0002354 ! results in development of cardiac Purk [Term] id: GO:0003168 name: Purkinje myocyte differentiation +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0060932 ! His-Purkinje system cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:0002068 ! results in acquisition of features of Purkinje myocyte @@ -6908,6 +9050,7 @@ relationship: RO:0002315 CL:0002068 ! results in acquisition of features of Purk [Term] id: GO:0003169 name: coronary vein morphogenesis +def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] is_a: GO:0048845 ! venous blood vessel morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -6917,6 +9060,7 @@ relationship: RO:0002298 UBERON:0004148 ! results in morphogenesis of cardiac ve [Term] id: GO:0003197 name: endocardial cushion development +def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002062 ! results in development of endocardial cushion @@ -6926,6 +9070,7 @@ relationship: RO:0002296 UBERON:0002062 ! results in development of endocardial [Term] id: GO:0003203 name: endocardial cushion morphogenesis +def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0072132 ! mesenchyme morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardial cushion @@ -6936,6 +9081,7 @@ relationship: RO:0002298 UBERON:0002062 ! results in morphogenesis of endocardia [Term] id: GO:0003204 name: cardiac skeleton development +def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] is_a: GO:0061448 ! connective tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004292 ! results in development of cardiac skeleton @@ -6945,6 +9091,7 @@ relationship: RO:0002296 UBERON:0004292 ! results in development of cardiac skel [Term] id: GO:0003205 name: cardiac chamber development +def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004151 ! results in development of cardiac chamber @@ -6954,6 +9101,7 @@ relationship: RO:0002296 UBERON:0004151 ! results in development of cardiac cham [Term] id: GO:0003206 name: cardiac chamber morphogenesis +def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac chamber @@ -6964,6 +9112,7 @@ relationship: RO:0002298 UBERON:0004151 ! results in morphogenesis of cardiac ch [Term] id: GO:0003207 name: cardiac chamber formation +def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004151 ! results in formation of cardiac chamber @@ -6973,6 +9122,7 @@ relationship: RO:0002297 UBERON:0004151 ! results in formation of cardiac chambe [Term] id: GO:0003208 name: cardiac ventricle morphogenesis +def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ventricle @@ -6982,6 +9132,7 @@ relationship: RO:0002298 UBERON:0002082 ! results in morphogenesis of cardiac ve [Term] id: GO:0003209 name: cardiac atrium morphogenesis +def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac atrium @@ -6991,6 +9142,7 @@ relationship: RO:0002298 UBERON:0002081 ! results in morphogenesis of cardiac at [Term] id: GO:0003210 name: cardiac atrium formation +def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002081 ! results in formation of cardiac atrium @@ -7000,6 +9152,7 @@ relationship: RO:0002297 UBERON:0002081 ! results in formation of cardiac atrium [Term] id: GO:0003211 name: cardiac ventricle formation +def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002082 ! results in formation of cardiac ventricle @@ -7009,6 +9162,7 @@ relationship: RO:0002297 UBERON:0002082 ! results in formation of cardiac ventri [Term] id: GO:0003212 name: cardiac left atrium morphogenesis +def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardiac atrium @@ -7017,6 +9171,7 @@ relationship: RO:0002298 UBERON:0002079 ! results in morphogenesis of left cardi [Term] id: GO:0003213 name: cardiac right atrium morphogenesis +def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002078 ! results in morphogenesis of right cardiac atrium @@ -7025,6 +9180,7 @@ relationship: RO:0002298 UBERON:0002078 ! results in morphogenesis of right card [Term] id: GO:0003214 name: cardiac left ventricle morphogenesis +def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left ventricle @@ -7033,6 +9189,7 @@ relationship: RO:0002298 UBERON:0002084 ! results in morphogenesis of heart left [Term] id: GO:0003215 name: cardiac right ventricle morphogenesis +def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart right ventricle @@ -7041,6 +9198,7 @@ relationship: RO:0002298 UBERON:0002080 ! results in morphogenesis of heart righ [Term] id: GO:0003216 name: cardiac left atrium formation +def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002079 ! results in formation of left cardiac atrium @@ -7050,6 +9208,7 @@ relationship: RO:0002297 UBERON:0002079 ! results in formation of left cardiac a [Term] id: GO:0003217 name: cardiac right atrium formation +def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002078 ! results in formation of right cardiac atrium @@ -7059,6 +9218,7 @@ relationship: RO:0002297 UBERON:0002078 ! results in formation of right cardiac [Term] id: GO:0003218 name: cardiac left ventricle formation +def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002084 ! results in formation of heart left ventricle @@ -7068,6 +9228,7 @@ relationship: RO:0002297 UBERON:0002084 ! results in formation of heart left ven [Term] id: GO:0003219 name: cardiac right ventricle formation +def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002080 ! results in formation of heart right ventricle @@ -7077,6 +9238,7 @@ relationship: RO:0002297 UBERON:0002080 ! results in formation of heart right ve [Term] id: GO:0003220 name: left ventricular cardiac muscle tissue morphogenesis +def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac muscle of left ventricle @@ -7086,15 +9248,47 @@ relationship: RO:0002298 UBERON:0003382 ! results in morphogenesis of cardiac mu [Term] id: GO:0003221 name: right ventricular cardiac muscle tissue morphogenesis +def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle relationship: BFO:0000050 GO:0003215 ! part of cardiac right ventricle morphogenesis relationship: RO:0002298 UBERON:0003381 ! results in morphogenesis of cardiac muscle of right ventricle +[Term] +id: GO:0003222 +name: ventricular trabecula myocardium morphogenesis +def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] +is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis +is_a: GO:0061384 ! heart trabecula morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: RO:0002298 UBERON:0004126 ! results in morphogenesis of trabecular layer of ventricle +relationship: RO:0002298 UBERON:0004126 ! results in morphogenesis of trabecular layer of ventricle + +[Term] +id: GO:0003225 +name: left ventricular trabecular myocardium morphogenesis +def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart] +is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis +is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: RO:0002298 UBERON:0005064 ! results in morphogenesis of left ventricular trabecular myocardium +relationship: RO:0002298 UBERON:0005064 ! results in morphogenesis of left ventricular trabecular myocardium + +[Term] +id: GO:0003227 +name: right ventricular trabecular myocardium morphogenesis +def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart] +is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis +is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis +intersection_of: GO:0009653 ! anatomical structure morphogenesis +intersection_of: RO:0002298 UBERON:0005066 ! results in morphogenesis of right ventricular trabecular myocardium +relationship: RO:0002298 UBERON:0005066 ! results in morphogenesis of right ventricular trabecular myocardium + [Term] id: GO:0003228 name: atrial cardiac muscle tissue development +def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004490 ! results in development of cardiac muscle tissue of atrium @@ -7103,6 +9297,7 @@ relationship: RO:0002296 UBERON:0004490 ! results in development of cardiac musc [Term] id: GO:0003229 name: ventricular cardiac muscle tissue development +def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0018649 ! results in development of cardiac muscle tissue of ventricle @@ -7111,6 +9306,7 @@ relationship: RO:0002296 UBERON:0018649 ! results in development of cardiac musc [Term] id: GO:0003230 name: cardiac atrium development +def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002081 ! results in development of cardiac atrium @@ -7119,6 +9315,7 @@ relationship: RO:0002296 UBERON:0002081 ! results in development of cardiac atri [Term] id: GO:0003231 name: cardiac ventricle development +def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002082 ! results in development of cardiac ventricle @@ -7127,6 +9324,7 @@ relationship: RO:0002296 UBERON:0002082 ! results in development of cardiac vent [Term] id: GO:0003235 name: sinus venosus development +def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002063 ! results in development of sinus venosus @@ -7135,6 +9333,7 @@ relationship: RO:0002296 UBERON:0002063 ! results in development of sinus venosu [Term] id: GO:0003236 name: sinus venosus morphogenesis +def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus venosus @@ -7144,6 +9343,7 @@ relationship: RO:0002298 UBERON:0002063 ! results in morphogenesis of sinus veno [Term] id: GO:0003237 name: sinus venosus formation +def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002063 ! results in formation of sinus venosus @@ -7153,6 +9353,7 @@ relationship: RO:0002297 UBERON:0002063 ! results in formation of sinus venosus [Term] id: GO:0003241 name: growth involved in heart morphogenesis +def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis intersection_of: GO:0040007 ! growth intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis @@ -7162,6 +9363,7 @@ relationship: BFO:0000050 GO:0060419 ! part of heart growth [Term] id: GO:0003245 name: cardiac muscle tissue growth involved in heart morphogenesis +def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0055017 ! cardiac muscle tissue growth intersection_of: GO:0055017 ! cardiac muscle tissue growth @@ -7171,6 +9373,7 @@ relationship: BFO:0000050 GO:0055008 ! part of cardiac muscle tissue morphogenes [Term] id: GO:0003248 name: heart capillary growth +def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0006966 ! results in growth of coronary capillary @@ -7181,6 +9384,7 @@ relationship: RO:0002343 UBERON:0006966 ! results in growth of coronary capillar [Term] id: GO:0003253 name: cardiac neural crest cell migration involved in outflow tract morphogenesis +def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0001755 ! neural crest cell migration @@ -7190,6 +9394,7 @@ relationship: BFO:0000050 GO:0061309 ! part of cardiac neural crest cell develop [Term] id: GO:0003260 name: cardioblast migration +def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0060974 ! cell migration involved in heart formation intersection_of: GO:0016477 ! cell migration intersection_of: RO:0002565 CL:0002664 ! results in movement of cardioblast @@ -7198,6 +9403,7 @@ relationship: RO:0002565 CL:0002664 ! results in movement of cardioblast [Term] id: GO:0003272 name: endocardial cushion formation +def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0002062 ! results in formation of endocardial cushion @@ -7207,6 +9413,7 @@ relationship: RO:0002297 UBERON:0002062 ! results in formation of endocardial cu [Term] id: GO:0003273 name: cell migration involved in endocardial cushion formation +def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development intersection_of: GO:0016477 ! cell migration intersection_of: BFO:0000050 GO:0003272 ! part of endocardial cushion formation @@ -7215,6 +9422,7 @@ relationship: BFO:0000050 GO:0003272 ! part of endocardial cushion formation [Term] id: GO:0003275 name: apoptotic process involved in outflow tract morphogenesis +def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis @@ -7223,6 +9431,7 @@ relationship: BFO:0000050 GO:0003151 ! part of outflow tract morphogenesis [Term] id: GO:0003277 name: apoptotic process involved in endocardial cushion morphogenesis +def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis @@ -7231,6 +9440,7 @@ relationship: BFO:0000050 GO:0003203 ! part of endocardial cushion morphogenesis [Term] id: GO:0003278 name: apoptotic process involved in heart morphogenesis +def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart] is_a: GO:0060561 ! apoptotic process involved in morphogenesis intersection_of: GO:0006915 ! apoptotic process intersection_of: BFO:0000050 GO:0003007 ! part of heart morphogenesis @@ -7239,6 +9449,7 @@ relationship: BFO:0000050 GO:0003007 ! part of heart morphogenesis [Term] id: GO:0003279 name: cardiac septum development +def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002099 ! results in development of cardiac septum @@ -7248,6 +9459,7 @@ relationship: RO:0002296 UBERON:0002099 ! results in development of cardiac sept [Term] id: GO:0003281 name: ventricular septum development +def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002094 ! results in development of interventricular septum @@ -7257,6 +9469,7 @@ relationship: RO:0002296 UBERON:0002094 ! results in development of interventric [Term] id: GO:0003283 name: atrial septum development +def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002085 ! results in development of interatrial septum @@ -7266,6 +9479,7 @@ relationship: RO:0002296 UBERON:0002085 ! results in development of interatrial [Term] id: GO:0003292 name: cardiac septum cell differentiation +def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: RO:0002315 CL:2000022 ! results in acquisition of features of cardiac septum cell @@ -7275,23 +9489,67 @@ relationship: RO:0002315 CL:2000022 ! results in acquisition of features of card [Term] id: GO:0003298 name: physiological muscle hypertrophy +def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] is_a: GO:0014896 ! muscle hypertrophy [Term] id: GO:0003300 name: cardiac muscle hypertrophy +def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] is_a: GO:0014897 ! striated muscle hypertrophy [Term] id: GO:0003301 name: physiological cardiac muscle hypertrophy +def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0003298 ! physiological muscle hypertrophy is_a: GO:0003300 ! cardiac muscle hypertrophy relationship: BFO:0000050 GO:0055017 ! part of cardiac muscle tissue growth +[Term] +id: GO:0003309 +name: type B pancreatic cell differentiation +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: RO:0002315 CL:0000169 ! results in acquisition of features of type B pancreatic cell +relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development +relationship: RO:0002315 CL:0000169 ! results in acquisition of features of type B pancreatic cell + +[Term] +id: GO:0003310 +name: pancreatic A cell differentiation +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: RO:0002315 CL:0000171 ! results in acquisition of features of pancreatic A cell +relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development +relationship: RO:0002315 CL:0000171 ! results in acquisition of features of pancreatic A cell + +[Term] +id: GO:0003311 +name: pancreatic D cell differentiation +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: RO:0002315 CL:0000173 ! results in acquisition of features of pancreatic D cell +relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development +relationship: RO:0002315 CL:0000173 ! results in acquisition of features of pancreatic D cell + +[Term] +id: GO:0003312 +name: pancreatic PP cell differentiation +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] +is_a: GO:0035883 ! enteroendocrine cell differentiation +intersection_of: GO:0030154 ! cell differentiation +intersection_of: RO:0002315 CL:0002275 ! results in acquisition of features of pancreatic PP cell +relationship: BFO:0000050 GO:0031018 ! part of endocrine pancreas development +relationship: RO:0002315 CL:0002275 ! results in acquisition of features of pancreatic PP cell + [Term] id: GO:0003313 name: heart rudiment development +def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004291 ! results in development of heart rudiment @@ -7301,6 +9559,7 @@ relationship: RO:0002296 UBERON:0004291 ! results in development of heart rudime [Term] id: GO:0003314 name: heart rudiment morphogenesis +def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -7311,15 +9570,58 @@ relationship: RO:0002298 UBERON:0004291 ! results in morphogenesis of heart rudi [Term] id: GO:0003315 name: heart rudiment formation +def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004291 ! results in formation of heart rudiment relationship: BFO:0000050 GO:0003314 ! part of heart rudiment morphogenesis relationship: RO:0002297 UBERON:0004291 ! results in formation of heart rudiment +[Term] +id: GO:0003322 +name: pancreatic A cell development +def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0032502 ! developmental process +intersection_of: RO:0002296 CL:0000171 ! results in development of pancreatic A cell +relationship: BFO:0000050 GO:0003310 ! part of pancreatic A cell differentiation +relationship: RO:0002296 CL:0000171 ! results in development of pancreatic A cell + +[Term] +id: GO:0003323 +name: type B pancreatic cell development +def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0032502 ! developmental process +intersection_of: RO:0002296 CL:0000169 ! results in development of type B pancreatic cell +relationship: BFO:0000050 GO:0003309 ! part of type B pancreatic cell differentiation +relationship: RO:0002296 CL:0000169 ! results in development of type B pancreatic cell + +[Term] +id: GO:0003324 +name: pancreatic D cell development +def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0032502 ! developmental process +intersection_of: RO:0002296 CL:0000173 ! results in development of pancreatic D cell +relationship: BFO:0000050 GO:0003311 ! part of pancreatic D cell differentiation +relationship: RO:0002296 CL:0000173 ! results in development of pancreatic D cell + +[Term] +id: GO:0003325 +name: pancreatic PP cell development +def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +intersection_of: GO:0048468 ! cell development +intersection_of: RO:0002296 CL:0002275 ! results in development of pancreatic PP cell +relationship: BFO:0000050 GO:0003312 ! part of pancreatic PP cell differentiation +relationship: RO:0002296 CL:0002275 ! results in development of pancreatic PP cell + [Term] id: GO:0003341 name: cilium movement +def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. is_a: GO:0007018 ! microtubule-based movement intersection_of: GO:0007018 ! microtubule-based movement intersection_of: RO:0002565 GO:0005929 ! results in movement of cilium @@ -7331,6 +9633,7 @@ relationship: RO:0002565 GO:0005929 ! results in movement of cilium [Term] id: GO:0003342 name: proepicardium development +def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004160 ! results in development of proepicardium @@ -7340,6 +9643,7 @@ relationship: RO:0002296 UBERON:0004160 ! results in development of proepicardiu [Term] id: GO:0003343 name: septum transversum development +def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0004161 ! results in development of septum transversum @@ -7348,6 +9652,7 @@ relationship: RO:0002296 UBERON:0004161 ! results in development of septum trans [Term] id: GO:0003344 name: pericardium morphogenesis +def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -7358,6 +9663,7 @@ relationship: RO:0002298 UBERON:0002407 ! results in morphogenesis of pericardiu [Term] id: GO:0003348 name: cardiac endothelial cell differentiation +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0045446 ! endothelial cell differentiation intersection_of: GO:0030154 ! cell differentiation @@ -7367,6 +9673,8 @@ relationship: RO:0002315 CL:0010008 ! results in acquisition of features of card [Term] id: GO:0003352 name: regulation of cilium movement +def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003341 ! regulates cilium movement @@ -7375,6 +9683,8 @@ relationship: RO:0002211 GO:0003341 ! regulates cilium movement [Term] id: GO:0003353 name: positive regulation of cilium movement +def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation @@ -7384,6 +9694,8 @@ relationship: RO:0002213 GO:0003341 ! positively regulates cilium movement [Term] id: GO:0003354 name: negative regulation of cilium movement +def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation @@ -7393,6 +9705,7 @@ relationship: RO:0002212 GO:0003341 ! negatively regulates cilium movement [Term] id: GO:0003360 name: brainstem development +def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002298 ! results in development of brainstem @@ -7401,6 +9714,7 @@ relationship: RO:0002296 UBERON:0002298 ! results in development of brainstem [Term] id: GO:0003365 name: establishment of cell polarity involved in ameboidal cell migration +def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration @@ -7409,6 +9723,7 @@ relationship: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration [Term] id: GO:0003371 name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: BFO:0000050 GO:0001667 ! part of ameboidal-type cell migration @@ -7417,6 +9732,7 @@ relationship: BFO:0000050 GO:0003365 ! part of establishment of cell polarity in [Term] id: GO:0003379 name: establishment of cell polarity involved in gastrulation cell migration +def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration intersection_of: GO:0030010 ! establishment of cell polarity intersection_of: BFO:0000050 GO:0042074 ! part of cell migration involved in gastrulation @@ -7425,6 +9741,7 @@ relationship: BFO:0000050 GO:0042074 ! part of cell migration involved in gastru [Term] id: GO:0003380 name: establishment or maintenance of cytoskeleton polarity involved in gastrulation +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation @@ -7433,6 +9750,7 @@ relationship: BFO:0000050 GO:0003379 ! part of establishment of cell polarity in [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation +def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis intersection_of: GO:0003382 ! epithelial cell morphogenesis intersection_of: BFO:0000050 GO:0007369 ! part of gastrulation @@ -7441,6 +9759,7 @@ relationship: BFO:0000050 GO:0007369 ! part of gastrulation [Term] id: GO:0003382 name: epithelial cell morphogenesis +def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: RO:0002299 CL:0000066 ! results in maturation of epithelial cell @@ -7450,6 +9769,7 @@ relationship: RO:0002299 CL:0000066 ! results in maturation of epithelial cell [Term] id: GO:0003403 name: optic vesicle formation +def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0004128 ! results in formation of optic vesicle @@ -7460,6 +9780,7 @@ relationship: RO:0002297 UBERON:0004128 ! results in formation of optic vesicle [Term] id: GO:0003404 name: optic vesicle morphogenesis +def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis @@ -7470,6 +9791,7 @@ relationship: RO:0002298 UBERON:0004128 ! results in morphogenesis of optic vesi [Term] id: GO:0003407 name: neural retina development +def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0003902 ! results in development of retinal neural layer @@ -7479,6 +9801,7 @@ relationship: RO:0002296 UBERON:0003902 ! results in development of retinal neur [Term] id: GO:0003411 name: cell motility involved in camera-type eye morphogenesis +def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility intersection_of: GO:0048870 ! cell motility intersection_of: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis @@ -7487,6 +9810,7 @@ relationship: BFO:0000050 GO:0048593 ! part of camera-type eye morphogenesis [Term] id: GO:0003413 name: chondrocyte differentiation involved in endochondral bone morphogenesis +def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002062 ! chondrocyte differentiation intersection_of: GO:0002062 ! chondrocyte differentiation intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis @@ -7495,6 +9819,7 @@ relationship: BFO:0000050 GO:0060351 ! part of cartilage development involved in [Term] id: GO:0003414 name: chondrocyte morphogenesis involved in endochondral bone morphogenesis +def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090171 ! chondrocyte morphogenesis intersection_of: GO:0090171 ! chondrocyte morphogenesis intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis @@ -7503,6 +9828,7 @@ relationship: BFO:0000050 GO:0003433 ! part of chondrocyte development involved [Term] id: GO:0003416 name: endochondral bone growth +def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098868 ! bone growth intersection_of: GO:0048589 ! developmental growth intersection_of: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone @@ -7511,31 +9837,135 @@ relationship: RO:0002343 UBERON:0002513 ! results in growth of endochondral bone [Term] id: GO:0003433 name: chondrocyte development involved in endochondral bone morphogenesis +def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002063 ! chondrocyte development intersection_of: GO:0002063 ! chondrocyte development intersection_of: BFO:0000050 GO:0060350 ! part of endochondral bone morphogenesis relationship: BFO:0000050 GO:0003413 ! part of chondrocyte differentiation involved in endochondral bone morphogenesis +[Term] +id: GO:0003674 +name: molecular_function +def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt] +comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. +is_a: BFO:0000015 +disjoint_from: GO:0005575 ! cellular_component +disjoint_from: GO:0008150 ! biological_process + +[Term] +id: GO:0003824 +name: catalytic activity +def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] +xref: Wikipedia:Enzyme +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0004518 +name: nuclease activity +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] +comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0004536 +name: DNA nuclease activity +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] +xref: Reactome:R-HSA-211247 "Cleavage of DNA by DFF40" +xref: Reactome:R-HSA-5685994 "Long-range resection of DNA DSBs by EXO1 or DNA2" +xref: Reactome:R-HSA-6785986 "DNA nucleases unhook the interstrand crosslink (ICL)" +is_a: GO:0004518 ! nuclease activity +is_a: GO:0140097 ! catalytic activity, acting on DNA +relationship: BFO:0000050 GO:0006259 ! part of DNA metabolic process + +[Term] +id: GO:0005215 +name: transporter activity +def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells." [GOC:ai, GOC:dgf] +comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0005275 +name: amine transmembrane transporter activity +def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: RO:0004009 CHEBI:32952 ! has primary input +relationship: BFO:0000050 GO:0015837 ! part of amine transport +relationship: RO:0004009 CHEBI:32952 ! has primary input + +[Term] +id: GO:0005319 +name: lipid transporter activity +def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] +xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux" +xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx" +xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" +xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region" +xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region" +xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane" +xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL" +is_a: GO:0005215 ! transporter activity +intersection_of: GO:0005215 ! transporter activity +intersection_of: RO:0004009 CHEBI:18059 ! has primary input +relationship: BFO:0000050 GO:0006869 ! part of lipid transport +relationship: RO:0004009 CHEBI:18059 ! has primary input + +[Term] +id: GO:0005342 +name: organic acid transmembrane transporter activity +def: "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage." [ISBN:0198506732] +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: RO:0004009 CHEBI:64709 ! has primary input +relationship: BFO:0000050 GO:1903825 ! part of organic acid transmembrane transport +relationship: RO:0004009 CHEBI:64709 ! has primary input + +[Term] +id: GO:0005355 +name: glucose transmembrane transporter activity +def: "Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-499981 "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2" +xref: Reactome:R-HSA-5653873 "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen" +is_a: GO:0022857 ! transmembrane transporter activity +intersection_of: GO:0022857 ! transmembrane transporter activity +intersection_of: RO:0004009 CHEBI:4167 ! has primary input +relationship: BFO:0000050 GO:1904659 ! part of glucose transmembrane transport +relationship: RO:0004009 CHEBI:4167 ! has primary input + [Term] id: GO:0005575 name: cellular_component +def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt] +comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. +xref: NIF_Subcellular:sao1337158144 is_a: BFO:0000040 disjoint_from: GO:0008150 ! biological_process [Term] id: GO:0005576 name: extracellular region +def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] +comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. +xref: Wikipedia:Extracellular is_a: GO:0110165 ! cellular anatomical entity [Term] id: GO:0005577 name: fibrinogen complex +def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] is_a: GO:0032991 ! protein-containing complex relationship: BFO:0000050 GO:0005615 ! part of extracellular space [Term] id: GO:0005581 name: collagen trimer +def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] +xref: Wikipedia:Collagen is_a: GO:0032991 ! protein-containing complex relationship: RO:0002160 NCBITaxon:33208 ! Metazoa relationship: RO:0002162 NCBITaxon:33208 {all_only="true"} ! Metazoa @@ -7543,6 +9973,7 @@ relationship: RO:0002162 NCBITaxon:33208 {all_only="true"} ! Metazoa [Term] id: GO:0005583 name: fibrillar collagen trimer +def: "Any triple helical collagen trimer that forms fibrils." [GOC:mah, ISBN:0721639976, PMID:21421911] is_a: GO:0005581 ! collagen trimer intersection_of: GO:0005581 ! collagen trimer intersection_of: BFO:0000050 GO:0098643 ! part of banded collagen fibril @@ -7552,34 +9983,49 @@ relationship: BFO:0000050 GO:0098643 ! part of banded collagen fibril [Term] id: GO:0005585 name: collagen type II trimer +def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] +xref: Wikipedia:Collagen_type_II is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005587 name: collagen type IV trimer +def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [ISBN:0721639976, PMID:19693541, PMID:21421911] +xref: Wikipedia:Collagen_type_IV is_a: GO:0098642 ! network-forming collagen trimer is_a: GO:0098651 ! basement membrane collagen trimer [Term] id: GO:0005604 name: basement membrane +def: "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934] +comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. +xref: Wikipedia:Basement_membrane is_a: GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0005615 name: extracellular space +def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] +comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. +xref: NIF_Subcellular:sao1425028079 is_a: GO:0110165 ! cellular anatomical entity relationship: BFO:0000050 GO:0005576 ! part of extracellular region [Term] id: GO:0005622 name: intracellular anatomical structure +def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] +xref: Wikipedia:Intracellular is_a: GO:0110165 ! cellular anatomical entity relationship: BFO:0000050 CL:0000000 ! part of cell [Term] id: GO:0005634 name: nucleus +def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] +xref: NIF_Subcellular:sao1702920020 +xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle disjoint_from: GO:0005737 ! cytoplasm relationship: RO:0002160 NCBITaxon:2759 ! Eukaryota @@ -7588,6 +10034,8 @@ relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! Eukaryota [Term] id: GO:0005635 name: nuclear envelope +def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] +xref: Wikipedia:Nuclear_envelope is_a: GO:0031967 ! organelle envelope relationship: BFO:0000050 GO:0005634 ! part of nucleus relationship: BFO:0000050 GO:0012505 ! part of endomembrane system @@ -7595,6 +10043,8 @@ relationship: BFO:0000050 GO:0012505 ! part of endomembrane system [Term] id: GO:0005640 name: nuclear outer membrane +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] +xref: NIF_Subcellular:sao1617136075 is_a: GO:0031965 ! nuclear membrane is_a: GO:0031968 ! organelle outer membrane intersection_of: GO:0016020 ! membrane @@ -7605,28 +10055,40 @@ relationship: RO:0002007 GO:0005634 ! bounding layer of nucleus [Term] id: GO:0005694 name: chromosome +def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] +comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. +xref: Wikipedia:Chromosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005730 name: nucleolus +def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] +xref: NIF_Subcellular:sao1820400233 +xref: Wikipedia:Nucleolus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: BFO:0000050 GO:0031981 ! part of nuclear lumen [Term] id: GO:0005737 name: cytoplasm +def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] +xref: Wikipedia:Cytoplasm is_a: GO:0110165 ! cellular anatomical entity relationship: BFO:0000050 GO:0005622 ! part of intracellular anatomical structure [Term] id: GO:0005764 name: lysosome +def: "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] +xref: NIF_Subcellular:sao585356902 +xref: Wikipedia:Lysosome is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0005765 name: lysosomal membrane +def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] is_a: GO:0098852 ! lytic vacuole membrane intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005764 ! bounding layer of lysosome @@ -7636,17 +10098,22 @@ relationship: RO:0002007 GO:0005764 ! bounding layer of lysosome [Term] id: GO:0005766 name: primary lysosome +def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] +xref: NIF_Subcellular:sao1140587416 is_a: GO:0005764 ! lysosome [Term] id: GO:0005773 name: vacuole +def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] +xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0005774 name: vacuolar membrane +def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] is_a: GO:0098588 ! bounding membrane of organelle intersection_of: GO:0016020 ! membrane intersection_of: RO:0002007 GO:0005773 ! bounding layer of vacuole @@ -7656,6 +10123,7 @@ relationship: RO:0002007 GO:0005773 ! bounding layer of vacuole [Term] id: GO:0005775 name: vacuolar lumen +def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: BFO:0000050 GO:0005773 ! part of vacuole @@ -7664,6 +10132,10 @@ relationship: BFO:0000050 GO:0005773 ! part of vacuole [Term] id: GO:0005794 name: Golgi apparatus +def: "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732] +comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. +xref: NIF_Subcellular:sao451912436 +xref: Wikipedia:Golgi_apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: BFO:0000050 GO:0005737 ! part of cytoplasm relationship: BFO:0000050 GO:0012505 ! part of endomembrane system @@ -7673,11 +10145,17 @@ relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! Eukaryota [Term] id: GO:0005798 name: Golgi-associated vesicle +def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] +comment: Note that this definition includes vesicles that are transiently associated with the Golgi. +xref: NIF_Subcellular:sao819927218 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0005840 name: ribosome +def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] +xref: NIF_Subcellular:sao1429207766 +xref: Wikipedia:Ribosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle relationship: BFO:0000051 CHEBI:33697 ! has part relationship: BFO:0000051 PR:000000001 ! has part @@ -7686,17 +10164,23 @@ relationship: RO:0002216 GO:0006412 ! capable of part of translation [Term] id: GO:0005856 name: cytoskeleton +def: "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875] +xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005874 name: microtubule +def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] +xref: NIF_Subcellular:sao1846835077 +xref: Wikipedia:Microtubule is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: BFO:0000050 GO:0015630 ! part of microtubule cytoskeleton [Term] id: GO:0005879 name: axonemal microtubule +def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194] is_a: GO:0005881 ! cytoplasmic microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005930 ! part of axoneme @@ -7705,6 +10189,7 @@ relationship: BFO:0000050 GO:0005930 ! part of axoneme [Term] id: GO:0005880 name: nuclear microtubule +def: "Any microtubule in the nucleus of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005634 ! part of nucleus @@ -7713,6 +10198,7 @@ relationship: BFO:0000050 GO:0005634 ! part of nucleus [Term] id: GO:0005881 name: cytoplasmic microtubule +def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: BFO:0000050 GO:0005737 ! part of cytoplasm @@ -7721,18 +10207,29 @@ relationship: BFO:0000050 GO:0005737 ! part of cytoplasm [Term] id: GO:0005884 name: actin filament +def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] +xref: FMA:63850 +xref: NIF_Subcellular:sao1588493326 +xref: Wikipedia:Actin is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: BFO:0000050 GO:0015629 ! part of actin cytoskeleton [Term] id: GO:0005886 name: plasma membrane +def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] +xref: NIF_Subcellular:sao1663586795 +xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: BFO:0000050 GO:0071944 ! part of cell periphery [Term] id: GO:0005902 name: microvillus +def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194] +comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. +xref: NIF_Subcellular:sao671419673 +xref: Wikipedia:Microvillus is_a: GO:0098858 ! actin-based cell projection relationship: BFO:0000050 CL:0000066 ! part of epithelial cell relationship: BFO:0000051 GO:0032432 ! has part actin filament bundle @@ -7740,11 +10237,18 @@ relationship: BFO:0000051 GO:0032432 ! has part actin filament bundle [Term] id: GO:0005911 name: cell-cell junction +def: "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] +xref: NIF_Subcellular:sao1922892319 is_a: GO:0070161 ! anchoring junction [Term] id: GO:0005929 name: cilium +def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. +xref: FMA:67181 +xref: NIF_Subcellular:sao787716553 +xref: Wikipedia:Cilium is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: BFO:0000051 GO:0030990 ! has part intraciliary transport particle @@ -7754,6 +10258,9 @@ relationship: RO:0002162 NCBITaxon:2759 {all_only="true"} ! Eukaryota [Term] id: GO:0005930 name: axoneme +def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. +xref: Wikipedia:Axoneme is_a: GO:0110165 ! cellular anatomical entity relationship: BFO:0000050 GO:0005856 ! part of cytoskeleton relationship: BFO:0000050 GO:0097014 ! part of ciliary plasm @@ -7762,6 +10269,8 @@ relationship: BFO:0000051 GO:0005874 ! has part microtubule [Term] id: GO:0005938 name: cell cortex +def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] +xref: Wikipedia:Cell_cortex is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 GO:0071944 ! part of cell periphery @@ -7770,6 +10279,8 @@ relationship: BFO:0000050 GO:0071944 ! part of cell periphery [Term] id: GO:0005975 name: carbohydrate metabolic process +def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732] +xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16646 ! has primary input or output @@ -7778,30 +10289,159 @@ relationship: RO:0004007 CHEBI:16646 ! has primary input or output [Term] id: GO:0005976 name: polysaccharide metabolic process +def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18154 ! has primary input or output relationship: RO:0004007 CHEBI:18154 ! has primary input or output +[Term] +id: GO:0005977 +name: glycogen metabolic process +def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0006112 ! energy reserve metabolic process +is_a: GO:0044042 ! glucan metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: RO:0004007 CHEBI:28087 ! has primary input or output +relationship: RO:0004007 CHEBI:28087 ! has primary input or output + +[Term] +id: GO:0005978 +name: glycogen biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] +xref: MetaCyc:GLYCOGENSYNTH-PWY +xref: MetaCyc:PWY-5067 +xref: MetaCyc:PWY-7900 +is_a: GO:0005977 ! glycogen metabolic process +is_a: GO:0009250 ! glucan biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: RO:0004008 CHEBI:28087 ! has primary output +relationship: RO:0004008 CHEBI:28087 ! has primary output + +[Term] +id: GO:0005979 +name: regulation of glycogen biosynthetic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] +is_a: GO:0010962 ! regulation of glucan biosynthetic process +is_a: GO:0070873 ! regulation of glycogen metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0005978 ! regulates glycogen biosynthetic process +relationship: RO:0002211 GO:0005978 ! regulates glycogen biosynthetic process + +[Term] +id: GO:0005980 +name: glycogen catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] +xref: MetaCyc:GLYCOCAT-PWY +xref: MetaCyc:PWY-5941 +xref: MetaCyc:PWY-7662 +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:28087 ! has primary input +relationship: RO:0004009 CHEBI:28087 ! has primary input + +[Term] +id: GO:0005981 +name: regulation of glycogen catabolic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +is_a: GO:0070873 ! regulation of glycogen metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0005980 ! regulates glycogen catabolic process +relationship: RO:0002211 GO:0005980 ! regulates glycogen catabolic process + +[Term] +id: GO:0006006 +name: glucose metabolic process +def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] +is_a: GO:0019318 ! hexose metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: RO:0004007 CHEBI:4167 ! has primary input or output +relationship: RO:0004007 CHEBI:4167 ! has primary input or output + +[Term] +id: GO:0006007 +name: glucose catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:4167 ! has primary input +relationship: RO:0004009 CHEBI:4167 ! has primary input + [Term] id: GO:0006024 name: glycosaminoglycan biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] is_a: GO:0009058 ! biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: RO:0004008 CHEBI:18085 ! has primary output relationship: RO:0004008 CHEBI:18085 ! has primary output +[Term] +id: GO:0006027 +name: glycosaminoglycan catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:18085 ! has primary input +relationship: RO:0004009 CHEBI:18085 ! has primary input + +[Term] +id: GO:0006082 +name: organic acid metabolic process +def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0044281 ! small molecule metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: RO:0004007 CHEBI:64709 ! has primary input or output +relationship: RO:0004007 CHEBI:64709 ! has primary input or output + +[Term] +id: GO:0006091 +name: generation of precursor metabolites and energy +def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006094 +name: gluconeogenesis +def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] +xref: MetaCyc:GLUCONEO-PWY +xref: Wikipedia:Gluconeogenesis +is_a: GO:0009058 ! biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: RO:0004008 CHEBI:4167 ! has primary output +relationship: RO:0004008 CHEBI:4167 ! has primary output + [Term] id: GO:0006109 name: regulation of carbohydrate metabolic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process relationship: RO:0002211 GO:0005975 ! regulates carbohydrate metabolic process +[Term] +id: GO:0006111 +name: regulation of gluconeogenesis +def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators] +is_a: GO:0009889 ! regulation of biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0006094 ! regulates gluconeogenesis +relationship: RO:0002211 GO:0006094 ! regulates gluconeogenesis + +[Term] +id: GO:0006112 +name: energy reserve metabolic process +def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] +is_a: GO:0015980 ! energy derivation by oxidation of organic compounds + [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process +def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:61120 ! has primary input or output @@ -7810,27 +10450,61 @@ relationship: RO:0004007 CHEBI:61120 ! has primary input or output [Term] id: GO:0006259 name: DNA metabolic process +def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:16991 ! has primary input or output relationship: RO:0004007 CHEBI:16991 ! has primary input or output +[Term] +id: GO:0006308 +name: DNA catabolic process +def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732] +is_a: GO:0009057 ! macromolecule catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:16991 ! has primary input +relationship: BFO:0000051 GO:0004536 ! has part DNA nuclease activity +relationship: RO:0004009 CHEBI:16991 ! has primary input + +[Term] +id: GO:0006309 +name: apoptotic DNA fragmentation +def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] +comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). +is_a: GO:0006308 ! DNA catabolic process +intersection_of: GO:0006308 ! DNA catabolic process +intersection_of: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes +relationship: BFO:0000050 GO:0030262 ! part of apoptotic nuclear changes + [Term] id: GO:0006325 name: chromatin organization +def: "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130] is_a: GO:0071824 ! protein-DNA complex organization intersection_of: GO:0016043 ! cellular component organization intersection_of: RO:0002592 GO:0000785 ! results in organization of chromatin relationship: RO:0002592 GO:0000785 ! results in organization of chromatin +[Term] +id: GO:0006401 +name: RNA catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:33697 ! has primary input +relationship: RO:0004009 CHEBI:33697 ! has primary input + [Term] id: GO:0006403 name: RNA localization +def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0006412 name: translation +def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] +xref: Wikipedia:Translation_(genetics) is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0019538 ! protein metabolic process intersection_of: GO:0009058 ! biosynthetic process @@ -7845,6 +10519,7 @@ relationship: RO:0004008 CHEBI:36080 ! has primary output [Term] id: GO:0006413 name: translational initiation +def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] is_a: GO:0044237 ! cellular metabolic process relationship: BFO:0000050 GO:0006412 ! part of translation relationship: RO:0002224 GO:0001677 ! starts with formation of translation initiation ternary complex @@ -7852,18 +10527,21 @@ relationship: RO:0002224 GO:0001677 ! starts with formation of translation initi [Term] id: GO:0006414 name: translational elongation +def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: BFO:0000050 GO:0006412 ! part of translation [Term] id: GO:0006415 name: translational termination +def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] is_a: GO:0032984 ! protein-containing complex disassembly relationship: BFO:0000050 GO:0006412 ! part of translation [Term] id: GO:0006417 name: regulation of translation +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] is_a: GO:0010608 ! post-transcriptional regulation of gene expression is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation @@ -7873,6 +10551,7 @@ relationship: RO:0002211 GO:0006412 ! regulates translation [Term] id: GO:0006446 name: regulation of translational initiation +def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006413 ! regulates translational initiation @@ -7881,6 +10560,7 @@ relationship: RO:0002211 GO:0006413 ! regulates translational initiation [Term] id: GO:0006448 name: regulation of translational elongation +def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006414 ! regulates translational elongation @@ -7889,15 +10569,26 @@ relationship: RO:0002211 GO:0006414 ! regulates translational elongation [Term] id: GO:0006449 name: regulation of translational termination +def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation is_a: GO:0043244 ! regulation of protein-containing complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006415 ! regulates translational termination relationship: RO:0002211 GO:0006415 ! regulates translational termination +[Term] +id: GO:0006516 +name: glycoprotein catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] +is_a: GO:0009057 ! macromolecule catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:17089 ! has primary input +relationship: RO:0004009 CHEBI:17089 ! has primary input + [Term] id: GO:0006518 name: peptide metabolic process +def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators] is_a: GO:0008152 ! metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:60466 ! has primary input or output @@ -7906,11 +10597,13 @@ relationship: RO:0004007 CHEBI:60466 ! has primary input or output [Term] id: GO:0006576 name: biogenic amine metabolic process +def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0006584 name: catecholamine metabolic process +def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] is_a: GO:0006576 ! biogenic amine metabolic process is_a: GO:0009712 ! catechol-containing compound metabolic process intersection_of: GO:0008152 ! metabolic process @@ -7920,19 +10613,58 @@ relationship: RO:0004007 CHEBI:33567 ! has primary input or output [Term] id: GO:0006629 name: lipid metabolic process +def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] +xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:18059 ! has primary input or output relationship: RO:0004007 CHEBI:18059 ! has primary input or output +[Term] +id: GO:0006694 +name: steroid biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] +xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: RO:0004008 CHEBI:35341 ! has primary output +relationship: RO:0004008 CHEBI:35341 ! has primary output + +[Term] +id: GO:0006699 +name: bile acid biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008206 ! bile acid metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: RO:0004008 CHEBI:36235 ! has primary output +relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa +relationship: RO:0002162 NCBITaxon:6072 {all_only="true"} ! Eumetazoa +relationship: RO:0004008 CHEBI:36235 ! has primary output + +[Term] +id: GO:0006706 +name: steroid catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:35341 ! has primary input +relationship: RO:0004009 CHEBI:35341 ! has primary input + [Term] id: GO:0006810 name: transport +def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] +comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. is_a: GO:0051234 ! establishment of localization [Term] id: GO:0006811 name: monoatomic ion transport +def: "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:24867 ! has primary input @@ -7941,6 +10673,7 @@ relationship: RO:0004009 CHEBI:24867 ! has primary input [Term] id: GO:0006837 name: serotonin transport +def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:350546 ! has primary input @@ -7949,6 +10682,7 @@ relationship: RO:0004009 CHEBI:350546 ! has primary input [Term] id: GO:0006858 name: extracellular transport +def: "The transport of substances that occurs outside cells." [GOC:go_curators] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: BFO:0000066 GO:0005576 ! occurs in extracellular region @@ -7957,15 +10691,26 @@ relationship: BFO:0000066 GO:0005576 ! occurs in extracellular region [Term] id: GO:0006869 name: lipid transport +def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] is_a: GO:0006810 ! transport intersection_of: GO:0006810 ! transport intersection_of: RO:0004009 CHEBI:18059 ! has primary input relationship: BFO:0000050 GO:0010876 ! part of lipid localization relationship: RO:0004009 CHEBI:18059 ! has primary input +[Term] +id: GO:0006873 +name: intracellular monoatomic ion homeostasis +def: "A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah] +is_a: GO:0019725 ! cellular homeostasis +intersection_of: GO:0019725 ! cellular homeostasis +intersection_of: RO:0002332 CHEBI:24867 ! regulates levels of +relationship: RO:0002332 CHEBI:24867 ! regulates levels of + [Term] id: GO:0006886 name: intracellular protein transport +def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0006810 ! transport @@ -7976,6 +10721,8 @@ relationship: BFO:0000050 GO:0008104 ! part of protein localization [Term] id: GO:0006887 name: exocytosis +def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285] +xref: Wikipedia:Exocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell intersection_of: GO:0006810 ! transport @@ -7986,11 +10733,13 @@ relationship: RO:0002608 GO:0070382 ! process has causal agent exocytic vesicle [Term] id: GO:0006892 name: post-Golgi vesicle-mediated transport +def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah] is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006893 name: Golgi to plasma membrane transport +def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane intersection_of: GO:0016192 ! vesicle-mediated transport @@ -8001,6 +10750,7 @@ relationship: RO:0002338 GO:0005794 ! has target start location Golgi apparatus [Term] id: GO:0006896 name: Golgi to vacuole transport +def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0007034 ! vacuolar transport intersection_of: GO:0016192 ! vesicle-mediated transport @@ -8013,6 +10763,8 @@ relationship: RO:0002339 GO:0005773 ! has target end location vacuole [Term] id: GO:0006897 name: endocytosis +def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis] +xref: Wikipedia:Endocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0098657 ! import into cell relationship: BFO:0000051 GO:0006900 ! has part vesicle budding from membrane @@ -8022,6 +10774,7 @@ relationship: RO:0002339 GO:0031410 ! has target end location cytoplasmic vesicl [Term] id: GO:0006900 name: vesicle budding from membrane +def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] is_a: GO:0016050 ! vesicle organization is_a: GO:0061024 ! membrane organization relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport @@ -8029,6 +10782,7 @@ relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport [Term] id: GO:0006903 name: vesicle targeting +def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] is_a: GO:0009987 ! cellular process relationship: BFO:0000050 GO:0016192 ! part of vesicle-mediated transport relationship: BFO:0000050 GO:0051650 ! part of establishment of vesicle localization @@ -8036,6 +10790,7 @@ relationship: BFO:0000050 GO:0051650 ! part of establishment of vesicle localiza [Term] id: GO:0006906 name: vesicle fusion +def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] is_a: GO:0016050 ! vesicle organization is_a: GO:0090174 ! organelle membrane fusion intersection_of: GO:0009987 ! cellular process @@ -8046,11 +10801,15 @@ relationship: RO:0012008 GO:0012506 ! results in fusion of vesicle membrane [Term] id: GO:0006909 name: phagocytosis +def: "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] +xref: Wikipedia:Phagocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006915 name: apoptotic process +def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] +xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death relationship: RO:0002160 NCBITaxon:33154 ! Opisthokonta relationship: RO:0002162 NCBITaxon:33154 {all_only="true"} ! Opisthokonta @@ -8060,6 +10819,7 @@ relationship: RO:0002230 GO:0097194 ! ends with execution phase of apoptosis [Term] id: GO:0006921 name: cellular component disassembly involved in execution phase of apoptosis +def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb] is_a: GO:0022411 ! cellular component disassembly intersection_of: GO:0022411 ! cellular component disassembly intersection_of: BFO:0000050 GO:0097194 ! part of execution phase of apoptosis @@ -8068,23 +10828,29 @@ relationship: BFO:0000050 GO:0097194 ! part of execution phase of apoptosis [Term] id: GO:0006925 name: inflammatory cell apoptotic process +def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis] is_a: GO:0006915 ! apoptotic process [Term] id: GO:0006935 name: chemotaxis +def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] +xref: Wikipedia:Chemotaxis is_a: GO:0042330 ! taxis relationship: BFO:0000050 GO:0042221 ! part of response to chemical [Term] id: GO:0006936 name: muscle contraction +def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] +xref: Wikipedia:Muscle_contraction is_a: GO:0003012 ! muscle system process relationship: BFO:0000066 UBERON:0002385 ! occurs in muscle tissue [Term] id: GO:0006937 name: regulation of muscle contraction +def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006936 ! regulates muscle contraction @@ -8093,6 +10859,7 @@ relationship: RO:0002211 GO:0006936 ! regulates muscle contraction [Term] id: GO:0006939 name: smooth muscle contraction +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732] is_a: GO:0006936 ! muscle contraction intersection_of: GO:0006936 ! muscle contraction intersection_of: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue @@ -8101,6 +10868,7 @@ relationship: BFO:0000066 UBERON:0001135 ! occurs in smooth muscle tissue [Term] id: GO:0006940 name: regulation of smooth muscle contraction +def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006939 ! regulates smooth muscle contraction @@ -8109,12 +10877,14 @@ relationship: RO:0002211 GO:0006939 ! regulates smooth muscle contraction [Term] id: GO:0006941 name: striated muscle contraction +def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732] is_a: GO:0006936 ! muscle contraction relationship: BFO:0000066 UBERON:0002036 ! occurs in striated muscle tissue [Term] id: GO:0006942 name: regulation of striated muscle contraction +def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006941 ! regulates striated muscle contraction @@ -8123,6 +10893,7 @@ relationship: RO:0002211 GO:0006941 ! regulates striated muscle contraction [Term] id: GO:0006949 name: syncytium formation +def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732] is_a: GO:0009987 ! cellular process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis @@ -8132,16 +10903,21 @@ relationship: RO:0002297 CL:0000228 ! results in formation of multinucleate cell [Term] id: GO:0006950 name: response to stress +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006952 name: defense response +def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] is_a: GO:0006950 ! response to stress [Term] id: GO:0006954 name: inflammatory response +def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732] +xref: Wikipedia:Inflammation is_a: GO:0006952 ! defense response relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002162 NCBITaxon:7742 {all_only="true"} ! Vertebrata @@ -8149,12 +10925,15 @@ relationship: RO:0002162 NCBITaxon:7742 {all_only="true"} ! Vertebrata uPAR + long-chain fatty acid" +xref: Reactome:R-HSA-9023617 "Butyrylcholinesterase hydrolyzes acyl Ghrelin" +xref: Reactome:R-HSA-9023619 "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin" +xref: Reactome:R-HSA-9749609 "BCHE hydrolyzes ASA-" +is_a: GO:0016787 ! hydrolase activity + [Term] id: GO:0017126 name: nucleologenesis +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732] is_a: GO:0007000 ! nucleolus organization is_a: GO:0044085 ! cellular component biogenesis intersection_of: GO:0044085 ! cellular component biogenesis @@ -10892,6 +14622,7 @@ relationship: RO:0004008 GO:0005730 ! has primary output nucleolus [Term] id: GO:0017145 name: stem cell division +def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] is_a: GO:0051301 ! cell division intersection_of: GO:0051301 ! cell division intersection_of: RO:0004009 CL:0000034 ! has primary input stem cell @@ -10900,6 +14631,7 @@ relationship: RO:0004009 CL:0000034 ! has primary input stem cell [Term] id: GO:0017148 name: negative regulation of translation +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] is_a: GO:0006417 ! regulation of translation is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051248 ! negative regulation of protein metabolic process @@ -10910,6 +14642,7 @@ relationship: RO:0002212 GO:0006412 ! negatively regulates translation [Term] id: GO:0017157 name: regulation of exocytosis +def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0065007 ! biological regulation @@ -10919,22 +14652,45 @@ relationship: RO:0002211 GO:0006887 ! regulates exocytosis [Term] id: GO:0018958 name: phenol-containing compound metabolic process +def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] +comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. +xref: UM-BBD_pathwayID:phe is_a: GO:1901615 ! organic hydroxy compound metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 CHEBI:33853 ! has primary input or output relationship: RO:0004007 CHEBI:33853 ! has primary input or output +[Term] +id: GO:0019098 +name: reproductive behavior +def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr] +is_a: GO:0007610 ! behavior +is_a: GO:0048609 ! multicellular organismal reproductive process +intersection_of: GO:0007610 ! behavior +intersection_of: GO:0048609 ! multicellular organismal reproductive process + [Term] id: GO:0019216 name: regulation of lipid metabolic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006629 ! regulates lipid metabolic process relationship: RO:0002211 GO:0006629 ! regulates lipid metabolic process +[Term] +id: GO:0019218 +name: regulation of steroid metabolic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] +is_a: GO:0019216 ! regulation of lipid metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0008202 ! regulates steroid metabolic process +relationship: RO:0002211 GO:0008202 ! regulates steroid metabolic process + [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process +def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound metabolic process @@ -10943,6 +14699,7 @@ relationship: RO:0002211 GO:0006139 ! regulates nucleobase-containing compound m [Term] id: GO:0019222 name: regulation of metabolic process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0008152 ! regulates metabolic process @@ -10951,6 +14708,7 @@ relationship: RO:0002211 GO:0008152 ! regulates metabolic process [Term] id: GO:0019226 name: transmission of nerve impulse +def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194] is_a: GO:0050877 ! nervous system process relationship: BFO:0000050 GO:0007154 ! part of cell communication relationship: BFO:0000051 GO:0001508 ! has part action potential @@ -10959,6 +14717,7 @@ relationship: BFO:0000051 GO:0007268 ! has part chemical synaptic transmission [Term] id: GO:0019228 name: neuronal action potential +def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb] is_a: GO:0001508 ! action potential intersection_of: GO:0001508 ! action potential intersection_of: BFO:0000066 CL:0000540 ! occurs in neuron @@ -10968,19 +14727,71 @@ relationship: BFO:0000066 CL:0000540 ! occurs in neuron [Term] id: GO:0019233 name: sensory perception of pain +def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [GOC:curators] +xref: Wikipedia:Nociception is_a: GO:0007600 ! sensory perception +[Term] +id: GO:0019318 +name: hexose metabolic process +def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +is_a: GO:0008152 ! metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: RO:0004007 CHEBI:18133 ! has primary input or output +relationship: RO:0004007 CHEBI:18133 ! has primary input or output + +[Term] +id: GO:0019319 +name: hexose biosynthetic process +def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +is_a: GO:0009058 ! biosynthetic process +intersection_of: GO:0009058 ! biosynthetic process +intersection_of: RO:0004008 CHEBI:18133 ! has primary output +relationship: RO:0004008 CHEBI:18133 ! has primary output + +[Term] +id: GO:0019320 +name: hexose catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:18133 ! has primary input +relationship: RO:0004009 CHEBI:18133 ! has primary input + +[Term] +id: GO:0019336 +name: phenol-containing compound catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] +xref: MetaCyc:PHENOLDEG-PWY +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:33853 ! has primary input +relationship: RO:0004009 CHEBI:33853 ! has primary input + [Term] id: GO:0019538 name: protein metabolic process +def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +xref: Wikipedia:Protein_metabolism is_a: GO:0044238 ! primary metabolic process intersection_of: GO:0008152 ! metabolic process intersection_of: RO:0004007 PR:000000001 ! has primary input or output relationship: RO:0004007 PR:000000001 ! has primary input or output +[Term] +id: GO:0019614 +name: catechol-containing compound catabolic process +def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] +is_a: GO:0009056 ! catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: RO:0004009 CHEBI:33566 ! has primary input +relationship: RO:0004009 CHEBI:33566 ! has primary input + [Term] id: GO:0019725 name: cellular homeostasis +def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] is_a: GO:0042592 ! homeostatic process intersection_of: GO:0042592 ! homeostatic process intersection_of: BFO:0000066 CL:0000000 ! occurs in cell @@ -10989,24 +14800,40 @@ relationship: BFO:0000066 CL:0000000 ! occurs in cell relationship: RO:0002160 NCBITaxon:131567 ! cellular organisms relationship: RO:0002162 NCBITaxon:131567 {all_only="true"} ! cellular organisms +[Term] +id: GO:0019752 +name: carboxylic acid metabolic process +def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] +is_a: GO:0043436 ! oxoacid metabolic process +intersection_of: GO:0008152 ! metabolic process +intersection_of: RO:0004007 CHEBI:29067 ! has primary input or output +relationship: RO:0004007 CHEBI:29067 ! has primary input or output + [Term] id: GO:0019867 name: outer membrane +def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] is_a: GO:0016020 ! membrane [Term] id: GO:0019882 name: antigen processing and presentation +def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] +xref: Wikipedia:Antigen_presentation is_a: GO:0002376 ! immune system process [Term] id: GO:0019953 name: sexual reproduction +def: "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction] +comment: Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. +xref: Wikipedia:Sexual_reproduction is_a: GO:0022414 ! reproductive process [Term] id: GO:0021501 name: prechordal plate formation +def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: RO:0002297 UBERON:0003063 ! results in formation of prechordal plate @@ -11016,6 +14843,7 @@ relationship: RO:0002297 UBERON:0003063 ! results in formation of prechordal pla [Term] id: GO:0021510 name: spinal cord development +def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002240 ! results in development of spinal cord @@ -11025,6 +14853,7 @@ relationship: RO:0002296 UBERON:0002240 ! results in development of spinal cord [Term] id: GO:0021514 name: ventral spinal cord interneuron differentiation +def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation @@ -11036,6 +14865,7 @@ relationship: RO:0002315 CL:0000099 ! results in acquisition of features of inte [Term] id: GO:0021515 name: cell differentiation in spinal cord +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002240 ! occurs in spinal cord @@ -11045,6 +14875,7 @@ relationship: BFO:0000066 UBERON:0002240 ! occurs in spinal cord [Term] id: GO:0021517 name: ventral spinal cord development +def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development intersection_of: GO:0048856 ! anatomical structure development intersection_of: RO:0002296 UBERON:0002257 ! results in development of ventral horn of spinal cord @@ -11054,6 +14885,7 @@ relationship: RO:0002296 UBERON:0002257 ! results in development of ventral horn [Term] id: GO:0021522 name: spinal cord motor neuron differentiation +def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation intersection_of: GO:0030154 ! cell differentiation @@ -11064,12 +14896,14 @@ relationship: RO:0002315 CL:0011001 ! results in acquisition of features of spin [Term] id: GO:0021532 name: neural tube patterning +def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0003002 ! regionalization relationship: BFO:0000050 GO:0021915 ! part of neural tube development [Term] id: GO:0021533 name: cell differentiation in hindbrain +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] is_a: GO:0030154 ! cell differentiation intersection_of: GO:0030154 ! cell differentiation intersection_of: BFO:0000066 UBERON:0002028 ! occurs in hindbrain @@ -11081,6 +14915,7 @@ relationship: RO:0002162 NCBITaxon:89593 {all_only="true"} ! Craniata +relationship: RO:0002162 NCBITaxon:7742 {all_only="true"} ! Vertebrata + [Term] id: GO:1990768 name: gastric mucosal blood circulation +def: "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products." [PMID:10807413] is_a: GO:0008015 ! blood circulation intersection_of: GO:0008015 ! blood circulation intersection_of: BFO:0000066 UBERON:0004786 ! occurs in gastrointestinal system mucosa relationship: BFO:0000066 UBERON:0004786 ! occurs in gastrointestinal system mucosa +[Term] +id: GO:1990770 +name: small intestine smooth muscle contraction +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." [PMID:11991626] +is_a: GO:0006939 ! smooth muscle contraction +intersection_of: GO:0006939 ! smooth muscle contraction +intersection_of: BFO:0000066 UBERON:0002108 ! occurs in small intestine +relationship: BFO:0000050 GO:0014827 ! part of intestine smooth muscle contraction +relationship: BFO:0000066 UBERON:0002108 ! occurs in small intestine +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002162 NCBITaxon:7742 {all_only="true"} ! Vertebrata + [Term] id: GO:1990778 name: protein localization to cell periphery +def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] is_a: GO:0008104 ! protein localization intersection_of: GO:0008104 ! protein localization intersection_of: RO:0002339 GO:0071944 ! has target end location cell periphery @@ -30226,14 +39325,25 @@ relationship: RO:0002339 GO:0071944 ! has target end location cell periphery [Term] id: GO:1990849 name: vacuolar localization +def: "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell." [PMID:26283797] is_a: GO:0051640 ! organelle localization intersection_of: GO:0051179 ! localization intersection_of: RO:0004009 GO:0005773 ! has primary input vacuole relationship: RO:0004009 GO:0005773 ! has primary input vacuole +[Term] +id: GO:1990863 +name: acinar cell proliferation +def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538] +is_a: GO:0050673 ! epithelial cell proliferation +intersection_of: GO:0008283 ! cell population proliferation +intersection_of: RO:0012003 CL:0000622 ! acts on population of acinar cell +relationship: RO:0012003 CL:0000622 ! acts on population of acinar cell + [Term] id: GO:1990874 name: vascular associated smooth muscle cell proliferation +def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467] is_a: GO:0048659 ! smooth muscle cell proliferation intersection_of: GO:0008283 ! cell population proliferation intersection_of: RO:0012003 CL:0000359 ! acts on population of vascular associated smooth muscle cell @@ -30242,12 +39352,15 @@ relationship: RO:0012003 CL:0000359 ! acts on population of vascular associated [Term] id: GO:1990904 name: ribonucleoprotein complex +def: "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] +xref: Wikipedia:Ribonucleoprotein is_a: GO:0032991 ! protein-containing complex relationship: BFO:0000051 CHEBI:33697 ! has part [Term] id: GO:1990917 name: ooplasm +def: "The cytoplasm of an ovum." [PMID:19022436] is_a: GO:0005737 ! cytoplasm intersection_of: GO:0005737 ! cytoplasm intersection_of: BFO:0000050 CL:0000025 ! part of egg cell @@ -30256,6 +39369,7 @@ relationship: BFO:0000050 CL:0000025 ! part of egg cell [Term] id: GO:2000026 name: regulation of multicellular organismal development +def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation @@ -30265,6 +39379,7 @@ relationship: RO:0002211 GO:0007275 ! regulates multicellular organism developme [Term] id: GO:2000027 name: regulation of animal organ morphogenesis +def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis @@ -30273,6 +39388,7 @@ relationship: RO:0002211 GO:0009887 ! regulates animal organ morphogenesis [Term] id: GO:2000035 name: regulation of stem cell division +def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0017145 ! regulates stem cell division @@ -30281,14 +39397,48 @@ relationship: RO:0002211 GO:0017145 ! regulates stem cell division [Term] id: GO:2000068 name: regulation of defense response to insect +def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol] is_a: GO:0031347 ! regulation of defense response intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002213 ! regulates defense response to insect relationship: RO:0002211 GO:0002213 ! regulates defense response to insect +[Term] +id: GO:2000074 +name: regulation of type B pancreatic cell development +def: "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +is_a: GO:0060284 ! regulation of cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0003323 ! regulates type B pancreatic cell development +relationship: RO:0002211 GO:0003323 ! regulates type B pancreatic cell development + +[Term] +id: GO:2000077 +name: negative regulation of type B pancreatic cell development +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000074 ! regulation of type B pancreatic cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002212 GO:0003323 ! negatively regulates type B pancreatic cell development +relationship: RO:0002212 GO:0003323 ! negatively regulates type B pancreatic cell development + +[Term] +id: GO:2000078 +name: positive regulation of type B pancreatic cell development +def: "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000074 ! regulation of type B pancreatic cell development +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002213 GO:0003323 ! positively regulates type B pancreatic cell development +relationship: RO:0002213 GO:0003323 ! positively regulates type B pancreatic cell development + [Term] id: GO:2000106 name: regulation of leukocyte apoptotic process +def: "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process @@ -30297,6 +39447,7 @@ relationship: RO:0002211 GO:0071887 ! regulates leukocyte apoptotic process [Term] id: GO:2000107 name: negative regulation of leukocyte apoptotic process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30306,6 +39457,7 @@ relationship: RO:0002212 GO:0071887 ! negatively regulates leukocyte apoptotic p [Term] id: GO:2000108 name: positive regulation of leukocyte apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30315,6 +39467,7 @@ relationship: RO:0002213 GO:0071887 ! positively regulates leukocyte apoptotic p [Term] id: GO:2000109 name: regulation of macrophage apoptotic process +def: "Any process that modulates the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30324,6 +39477,7 @@ relationship: RO:0002211 GO:0071888 ! regulates macrophage apoptotic process [Term] id: GO:2000110 name: negative regulation of macrophage apoptotic process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process is_a: GO:2000109 ! regulation of macrophage apoptotic process @@ -30334,6 +39488,7 @@ relationship: RO:0002212 GO:0071888 ! negatively regulates macrophage apoptotic [Term] id: GO:2000111 name: positive regulation of macrophage apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process is_a: GO:2000109 ! regulation of macrophage apoptotic process @@ -30344,6 +39499,7 @@ relationship: RO:0002213 GO:0071888 ! positively regulates macrophage apoptotic [Term] id: GO:2000114 name: regulation of establishment of cell polarity +def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph] is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0030010 ! regulates establishment of cell polarity @@ -30352,6 +39508,7 @@ relationship: RO:0002211 GO:0030010 ! regulates establishment of cell polarity [Term] id: GO:2000136 name: regulation of cell proliferation involved in heart morphogenesis +def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061323 ! regulates cell proliferation involved in heart morphogenesis @@ -30360,6 +39517,7 @@ relationship: RO:0002211 GO:0061323 ! regulates cell proliferation involved in h [Term] id: GO:2000137 name: negative regulation of cell proliferation involved in heart morphogenesis +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation @@ -30369,6 +39527,7 @@ relationship: RO:0002212 GO:0061323 ! negatively regulates cell proliferation in [Term] id: GO:2000138 name: positive regulation of cell proliferation involved in heart morphogenesis +def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis intersection_of: GO:0065007 ! biological regulation @@ -30378,6 +39537,7 @@ relationship: RO:0002213 GO:0061323 ! positively regulates cell proliferation in [Term] id: GO:2000145 name: regulation of cell motility +def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah] is_a: GO:0040012 ! regulation of locomotion is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation @@ -30387,6 +39547,7 @@ relationship: RO:0002211 GO:0048870 ! regulates cell motility [Term] id: GO:2000146 name: negative regulation of cell motility +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah] is_a: GO:0040013 ! negative regulation of locomotion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:2000145 ! regulation of cell motility @@ -30397,6 +39558,7 @@ relationship: RO:0002212 GO:0048870 ! negatively regulates cell motility [Term] id: GO:2000147 name: positive regulation of cell motility +def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] is_a: GO:0040017 ! positive regulation of locomotion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:2000145 ! regulation of cell motility @@ -30407,6 +39569,7 @@ relationship: RO:0002213 GO:0048870 ! positively regulates cell motility [Term] id: GO:2000155 name: positive regulation of cilium-dependent cell motility +def: "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl] is_a: GO:1902019 ! regulation of cilium-dependent cell motility is_a: GO:2000147 ! positive regulation of cell motility intersection_of: GO:0065007 ! biological regulation @@ -30416,6 +39579,7 @@ relationship: RO:0002213 GO:0060285 ! positively regulates cilium-dependent cell [Term] id: GO:2000172 name: regulation of branching morphogenesis of a nerve +def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0060688 ! regulation of morphogenesis of a branching structure intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a nerve @@ -30424,6 +39588,7 @@ relationship: RO:0002211 GO:0048755 ! regulates branching morphogenesis of a ner [Term] id: GO:2000173 name: negative regulation of branching morphogenesis of a nerve +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve @@ -30434,6 +39599,7 @@ relationship: RO:0002212 GO:0048755 ! negatively regulates branching morphogenes [Term] id: GO:2000174 name: regulation of pro-T cell differentiation +def: "Any process that modulates the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] is_a: GO:0045580 ! regulation of T cell differentiation is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -30443,6 +39609,7 @@ relationship: RO:0002211 GO:0002572 ! regulates pro-T cell differentiation [Term] id: GO:2000175 name: negative regulation of pro-T cell differentiation +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] is_a: GO:0045581 ! negative regulation of T cell differentiation is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation @@ -30453,6 +39620,7 @@ relationship: RO:0002212 GO:0002572 ! negatively regulates pro-T cell differenti [Term] id: GO:2000176 name: positive regulation of pro-T cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] is_a: GO:0045582 ! positive regulation of T cell differentiation is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation is_a: GO:2000174 ! regulation of pro-T cell differentiation @@ -30463,6 +39631,7 @@ relationship: RO:0002213 GO:0002572 ! positively regulates pro-T cell differenti [Term] id: GO:2000177 name: regulation of neural precursor cell proliferation +def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferation @@ -30471,6 +39640,7 @@ relationship: RO:0002211 GO:0061351 ! regulates neural precursor cell proliferat [Term] id: GO:2000178 name: negative regulation of neural precursor cell proliferation +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -30480,6 +39650,7 @@ relationship: RO:0002212 GO:0061351 ! negatively regulates neural precursor cell [Term] id: GO:2000179 name: positive regulation of neural precursor cell proliferation +def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000177 ! regulation of neural precursor cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -30489,6 +39660,7 @@ relationship: RO:0002213 GO:0061351 ! positively regulates neural precursor cell [Term] id: GO:2000181 name: negative regulation of blood vessel morphogenesis +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:1901343 ! negative regulation of vasculature development intersection_of: GO:0065007 ! biological regulation @@ -30498,6 +39670,7 @@ relationship: RO:0002212 GO:0048514 ! negatively regulates blood vessel morphoge [Term] id: GO:2000194 name: regulation of female gonad development +def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol] is_a: GO:1905939 ! regulation of gonad development is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0065007 ! biological regulation @@ -30507,6 +39680,7 @@ relationship: RO:0002211 GO:0008585 ! regulates female gonad development [Term] id: GO:2000195 name: negative regulation of female gonad development +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol] is_a: GO:1905940 ! negative regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0065007 ! biological regulation @@ -30516,15 +39690,48 @@ relationship: RO:0002212 GO:0008585 ! negatively regulates female gonad developm [Term] id: GO:2000196 name: positive regulation of female gonad development +def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol] is_a: GO:1905941 ! positive regulation of gonad development is_a: GO:2000194 ! regulation of female gonad development intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0008585 ! positively regulates female gonad development relationship: RO:0002213 GO:0008585 ! positively regulates female gonad development +[Term] +id: GO:2000226 +name: regulation of pancreatic A cell differentiation +def: "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0003310 ! regulates pancreatic A cell differentiation +relationship: RO:0002211 GO:0003310 ! regulates pancreatic A cell differentiation + +[Term] +id: GO:2000227 +name: negative regulation of pancreatic A cell differentiation +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000226 ! regulation of pancreatic A cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002212 GO:0003310 ! negatively regulates pancreatic A cell differentiation +relationship: RO:0002212 GO:0003310 ! negatively regulates pancreatic A cell differentiation + +[Term] +id: GO:2000228 +name: positive regulation of pancreatic A cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000226 ! regulation of pancreatic A cell differentiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002213 GO:0003310 ! positively regulates pancreatic A cell differentiation +relationship: RO:0002213 GO:0003310 ! positively regulates pancreatic A cell differentiation + [Term] id: GO:2000241 name: regulation of reproductive process +def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0022414 ! regulates reproductive process @@ -30533,6 +39740,7 @@ relationship: RO:0002211 GO:0022414 ! regulates reproductive process [Term] id: GO:2000242 name: negative regulation of reproductive process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation @@ -30542,6 +39750,7 @@ relationship: RO:0002212 GO:0022414 ! negatively regulates reproductive process [Term] id: GO:2000243 name: positive regulation of reproductive process +def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation @@ -30551,6 +39760,7 @@ relationship: RO:0002213 GO:0022414 ! positively regulates reproductive process [Term] id: GO:2000248 name: negative regulation of establishment or maintenance of neuroblast polarity +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity is_a: GO:0045769 ! negative regulation of asymmetric cell division @@ -30561,6 +39771,7 @@ relationship: RO:0002212 GO:0045196 ! negatively regulates establishment or main [Term] id: GO:2000269 name: regulation of fibroblast apoptotic process +def: "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process @@ -30569,6 +39780,7 @@ relationship: RO:0002211 GO:0044346 ! regulates fibroblast apoptotic process [Term] id: GO:2000270 name: negative regulation of fibroblast apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30578,6 +39790,7 @@ relationship: RO:0002212 GO:0044346 ! negatively regulates fibroblast apoptotic [Term] id: GO:2000271 name: positive regulation of fibroblast apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000269 ! regulation of fibroblast apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30587,6 +39800,7 @@ relationship: RO:0002213 GO:0044346 ! positively regulates fibroblast apoptotic [Term] id: GO:2000278 name: regulation of DNA biosynthetic process +def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] is_a: GO:0009889 ! regulation of biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0071897 ! regulates DNA biosynthetic process @@ -30595,6 +39809,7 @@ relationship: RO:0002211 GO:0071897 ! regulates DNA biosynthetic process [Term] id: GO:2000279 name: negative regulation of DNA biosynthetic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0065007 ! biological regulation @@ -30604,6 +39819,7 @@ relationship: RO:0002212 GO:0071897 ! negatively regulates DNA biosynthetic proc [Term] id: GO:2000287 name: positive regulation of myotome development +def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000290 ! regulation of myotome development intersection_of: GO:0065007 ! biological regulation @@ -30613,6 +39829,7 @@ relationship: RO:0002213 GO:0061055 ! positively regulates myotome development [Term] id: GO:2000288 name: positive regulation of myoblast proliferation +def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation @@ -30622,6 +39839,7 @@ relationship: RO:0002213 GO:0051450 ! positively regulates myoblast proliferatio [Term] id: GO:2000290 name: regulation of myotome development +def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0061055 ! regulates myotome development @@ -30630,14 +39848,48 @@ relationship: RO:0002211 GO:0061055 ! regulates myotome development [Term] id: GO:2000291 name: regulation of myoblast proliferation +def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0051450 ! regulates myoblast proliferation relationship: RO:0002211 GO:0051450 ! regulates myoblast proliferation +[Term] +id: GO:2000292 +name: regulation of defecation +def: "Any process that modulates the frequency, rate or extent of defecation." [GOC:obol] +is_a: GO:0044058 ! regulation of digestive system process +is_a: GO:0044062 ! regulation of excretion +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0030421 ! regulates defecation +relationship: RO:0002211 GO:0030421 ! regulates defecation + +[Term] +id: GO:2000293 +name: negative regulation of defecation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." [GOC:obol] +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0060457 ! negative regulation of digestive system process +is_a: GO:2000292 ! regulation of defecation +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002212 GO:0030421 ! negatively regulates defecation +relationship: RO:0002212 GO:0030421 ! negatively regulates defecation + +[Term] +id: GO:2000294 +name: positive regulation of defecation +def: "Any process that activates or increases the frequency, rate or extent of defecation." [GOC:obol] +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0060456 ! positive regulation of digestive system process +is_a: GO:2000292 ! regulation of defecation +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002213 GO:0030421 ! positively regulates defecation +relationship: RO:0002213 GO:0030421 ! positively regulates defecation + [Term] id: GO:2000351 name: regulation of endothelial cell apoptotic process +def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic process @@ -30646,6 +39898,7 @@ relationship: RO:0002211 GO:0072577 ! regulates endothelial cell apoptotic proce [Term] id: GO:2000352 name: negative regulation of endothelial cell apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30655,6 +39908,7 @@ relationship: RO:0002212 GO:0072577 ! negatively regulates endothelial cell apop [Term] id: GO:2000353 name: positive regulation of endothelial cell apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2000351 ! regulation of endothelial cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30664,6 +39918,7 @@ relationship: RO:0002213 GO:0072577 ! positively regulates endothelial cell apop [Term] id: GO:2000374 name: regulation of oxygen metabolic process +def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072592 ! regulates oxygen metabolic process @@ -30672,6 +39927,7 @@ relationship: RO:0002211 GO:0072592 ! regulates oxygen metabolic process [Term] id: GO:2000375 name: negative regulation of oxygen metabolic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process." [GOC:mah] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process intersection_of: GO:0065007 ! biological regulation @@ -30681,6 +39937,7 @@ relationship: RO:0002212 GO:0072592 ! negatively regulates oxygen metabolic proc [Term] id: GO:2000376 name: positive regulation of oxygen metabolic process +def: "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process." [GOC:mah] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:2000374 ! regulation of oxygen metabolic process intersection_of: GO:0065007 ! biological regulation @@ -30690,6 +39947,7 @@ relationship: RO:0002213 GO:0072592 ! positively regulates oxygen metabolic proc [Term] id: GO:2000380 name: regulation of mesoderm development +def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007498 ! regulates mesoderm development @@ -30698,6 +39956,7 @@ relationship: RO:0002211 GO:0007498 ! regulates mesoderm development [Term] id: GO:2000381 name: negative regulation of mesoderm development +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation @@ -30707,6 +39966,7 @@ relationship: RO:0002212 GO:0007498 ! negatively regulates mesoderm development [Term] id: GO:2000382 name: positive regulation of mesoderm development +def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000380 ! regulation of mesoderm development intersection_of: GO:0065007 ! biological regulation @@ -30716,6 +39976,7 @@ relationship: RO:0002213 GO:0007498 ! positively regulates mesoderm development [Term] id: GO:2000383 name: regulation of ectoderm development +def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0007398 ! regulates ectoderm development @@ -30724,6 +39985,7 @@ relationship: RO:0002211 GO:0007398 ! regulates ectoderm development [Term] id: GO:2000384 name: negative regulation of ectoderm development +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation @@ -30733,6 +39995,7 @@ relationship: RO:0002212 GO:0007398 ! negatively regulates ectoderm development [Term] id: GO:2000385 name: positive regulation of ectoderm development +def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:2000383 ! regulation of ectoderm development intersection_of: GO:0065007 ! biological regulation @@ -30742,6 +40005,7 @@ relationship: RO:0002213 GO:0007398 ! positively regulates ectoderm development [Term] id: GO:2000401 name: regulation of lymphocyte migration +def: "Any process that modulates the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072676 ! regulates lymphocyte migration @@ -30750,6 +40014,7 @@ relationship: RO:0002211 GO:0072676 ! regulates lymphocyte migration [Term] id: GO:2000402 name: negative regulation of lymphocyte migration +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation @@ -30759,6 +40024,7 @@ relationship: RO:0002212 GO:0072676 ! negatively regulates lymphocyte migration [Term] id: GO:2000403 name: positive regulation of lymphocyte migration +def: "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah] is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation @@ -30768,6 +40034,7 @@ relationship: RO:0002213 GO:0072676 ! positively regulates lymphocyte migration [Term] id: GO:2000404 name: regulation of T cell migration +def: "Any process that modulates the frequency, rate or extent of T cell migration." [GOC:mah] is_a: GO:2000401 ! regulation of lymphocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0072678 ! regulates T cell migration @@ -30776,6 +40043,7 @@ relationship: RO:0002211 GO:0072678 ! regulates T cell migration [Term] id: GO:2000405 name: negative regulation of T cell migration +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah] is_a: GO:2000402 ! negative regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0065007 ! biological regulation @@ -30785,6 +40053,7 @@ relationship: RO:0002212 GO:0072678 ! negatively regulates T cell migration [Term] id: GO:2000406 name: positive regulation of T cell migration +def: "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah] is_a: GO:2000403 ! positive regulation of lymphocyte migration is_a: GO:2000404 ! regulation of T cell migration intersection_of: GO:0065007 ! biological regulation @@ -30794,6 +40063,7 @@ relationship: RO:0002213 GO:0072678 ! positively regulates T cell migration [Term] id: GO:2000471 name: regulation of hematopoietic stem cell migration +def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035701 ! regulates hematopoietic stem cell migration @@ -30802,6 +40072,7 @@ relationship: RO:0002211 GO:0035701 ! regulates hematopoietic stem cell migratio [Term] id: GO:2000472 name: negative regulation of hematopoietic stem cell migration +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration intersection_of: GO:0065007 ! biological regulation @@ -30811,6 +40082,7 @@ relationship: RO:0002212 GO:0035701 ! negatively regulates hematopoietic stem ce [Term] id: GO:2000473 name: positive regulation of hematopoietic stem cell migration +def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:2000471 ! regulation of hematopoietic stem cell migration intersection_of: GO:0065007 ! biological regulation @@ -30820,6 +40092,7 @@ relationship: RO:0002213 GO:0035701 ! positively regulates hematopoietic stem ce [Term] id: GO:2000495 name: regulation of cell proliferation involved in compound eye morphogenesis +def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0042127 ! regulation of cell population proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035736 ! regulates cell proliferation involved in compound eye morphogenesis @@ -30828,6 +40101,7 @@ relationship: RO:0002211 GO:0035736 ! regulates cell proliferation involved in c [Term] id: GO:2000496 name: negative regulation of cell proliferation involved in compound eye morphogenesis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0065007 ! biological regulation @@ -30837,6 +40111,7 @@ relationship: RO:0002212 GO:0035736 ! negatively regulates cell proliferation in [Term] id: GO:2000497 name: positive regulation of cell proliferation involved in compound eye morphogenesis +def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis intersection_of: GO:0065007 ! biological regulation @@ -30846,6 +40121,7 @@ relationship: RO:0002213 GO:0035736 ! positively regulates cell proliferation in [Term] id: GO:2000508 name: regulation of dendritic cell chemotaxis +def: "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0071675 ! regulation of mononuclear cell migration intersection_of: GO:0065007 ! biological regulation @@ -30855,6 +40131,7 @@ relationship: RO:0002211 GO:0002407 ! regulates dendritic cell chemotaxis [Term] id: GO:2000509 name: negative regulation of dendritic cell chemotaxis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0071676 ! negative regulation of mononuclear cell migration is_a: GO:2000508 ! regulation of dendritic cell chemotaxis @@ -30865,6 +40142,7 @@ relationship: RO:0002212 GO:0002407 ! negatively regulates dendritic cell chemot [Term] id: GO:2000510 name: positive regulation of dendritic cell chemotaxis +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0071677 ! positive regulation of mononuclear cell migration is_a: GO:2000508 ! regulation of dendritic cell chemotaxis @@ -30875,6 +40153,7 @@ relationship: RO:0002213 GO:0002407 ! positively regulates dendritic cell chemot [Term] id: GO:2000527 name: regulation of myeloid dendritic cell chemotaxis +def: "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000508 ! regulation of dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0002408 ! regulates myeloid dendritic cell chemotaxis @@ -30883,6 +40162,7 @@ relationship: RO:0002211 GO:0002408 ! regulates myeloid dendritic cell chemotaxi [Term] id: GO:2000528 name: negative regulation of myeloid dendritic cell chemotaxis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000509 ! negative regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation @@ -30892,6 +40172,7 @@ relationship: RO:0002212 GO:0002408 ! negatively regulates myeloid dendritic cel [Term] id: GO:2000529 name: positive regulation of myeloid dendritic cell chemotaxis +def: "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] is_a: GO:2000510 ! positive regulation of dendritic cell chemotaxis is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis intersection_of: GO:0065007 ! biological regulation @@ -30901,6 +40182,7 @@ relationship: RO:0002213 GO:0002408 ! positively regulates myeloid dendritic cel [Term] id: GO:2000542 name: negative regulation of gastrulation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0045992 ! negative regulation of embryonic development intersection_of: GO:0065007 ! biological regulation @@ -30910,6 +40192,7 @@ relationship: RO:0002212 GO:0007369 ! negatively regulates gastrulation [Term] id: GO:2000543 name: positive regulation of gastrulation +def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol] is_a: GO:0010470 ! regulation of gastrulation is_a: GO:0040019 ! positive regulation of embryonic development intersection_of: GO:0065007 ! biological regulation @@ -30919,6 +40202,7 @@ relationship: RO:0002213 GO:0007369 ! positively regulates gastrulation [Term] id: GO:2000547 name: regulation of dendritic cell dendrite assembly +def: "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097026 ! regulates dendritic cell dendrite assembly @@ -30927,6 +40211,7 @@ relationship: RO:0002211 GO:0097026 ! regulates dendritic cell dendrite assembly [Term] id: GO:2000548 name: negative regulation of dendritic cell dendrite assembly +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly intersection_of: GO:0065007 ! biological regulation @@ -30936,6 +40221,7 @@ relationship: RO:0002212 GO:0097026 ! negatively regulates dendritic cell dendri [Term] id: GO:2000549 name: positive regulation of dendritic cell dendrite assembly +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly intersection_of: GO:0065007 ! biological regulation @@ -30945,6 +40231,7 @@ relationship: RO:0002213 GO:0097026 ! positively regulates dendritic cell dendri [Term] id: GO:2000573 name: positive regulation of DNA biosynthetic process +def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0065007 ! biological regulation @@ -30954,6 +40241,7 @@ relationship: RO:0002213 GO:0071897 ! positively regulates DNA biosynthetic proc [Term] id: GO:2000647 name: negative regulation of stem cell proliferation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -30963,6 +40251,7 @@ relationship: RO:0002212 GO:0072089 ! negatively regulates stem cell proliferati [Term] id: GO:2000648 name: positive regulation of stem cell proliferation +def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0072091 ! regulation of stem cell proliferation intersection_of: GO:0065007 ! biological regulation @@ -30972,6 +40261,7 @@ relationship: RO:0002213 GO:0072089 ! positively regulates stem cell proliferati [Term] id: GO:2000668 name: regulation of dendritic cell apoptotic process +def: "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:2000106 ! regulation of leukocyte apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097048 ! regulates dendritic cell apoptotic process @@ -30980,6 +40270,7 @@ relationship: RO:0002211 GO:0097048 ! regulates dendritic cell apoptotic process [Term] id: GO:2000669 name: negative regulation of dendritic cell apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process is_a: GO:2000668 ! regulation of dendritic cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30989,6 +40280,7 @@ relationship: RO:0002212 GO:0097048 ! negatively regulates dendritic cell apopto [Term] id: GO:2000670 name: positive regulation of dendritic cell apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process is_a: GO:2000668 ! regulation of dendritic cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -30998,6 +40290,7 @@ relationship: RO:0002213 GO:0097048 ! positively regulates dendritic cell apopto [Term] id: GO:2000671 name: regulation of motor neuron apoptotic process +def: "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0043523 ! regulation of neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process @@ -31006,6 +40299,7 @@ relationship: RO:0002211 GO:0097049 ! regulates motor neuron apoptotic process [Term] id: GO:2000672 name: negative regulation of motor neuron apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0043524 ! negative regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -31015,15 +40309,46 @@ relationship: RO:0002212 GO:0097049 ! negatively regulates motor neuron apoptoti [Term] id: GO:2000673 name: positive regulation of motor neuron apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0043525 ! positive regulation of neuron apoptotic process is_a: GO:2000671 ! regulation of motor neuron apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process relationship: RO:0002213 GO:0097049 ! positively regulates motor neuron apoptotic process +[Term] +id: GO:2000674 +name: regulation of type B pancreatic cell apoptotic process +def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002211 GO:0097050 ! regulates type B pancreatic cell apoptotic process +relationship: RO:0002211 GO:0097050 ! regulates type B pancreatic cell apoptotic process + +[Term] +id: GO:2000675 +name: negative regulation of type B pancreatic cell apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002212 GO:0097050 ! negatively regulates type B pancreatic cell apoptotic process +relationship: RO:0002212 GO:0097050 ! negatively regulates type B pancreatic cell apoptotic process + +[Term] +id: GO:2000676 +name: positive regulation of type B pancreatic cell apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: RO:0002213 GO:0097050 ! positively regulates type B pancreatic cell apoptotic process +relationship: RO:0002213 GO:0097050 ! positively regulates type B pancreatic cell apoptotic process + [Term] id: GO:2000690 name: regulation of cardiac muscle cell myoblast differentiation +def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] is_a: GO:0045661 ! regulation of myoblast differentiation is_a: GO:0051890 ! regulation of cardioblast differentiation intersection_of: GO:0065007 ! biological regulation @@ -31033,6 +40358,7 @@ relationship: RO:0002211 GO:0060379 ! regulates cardiac muscle cell myoblast dif [Term] id: GO:2000691 name: negative regulation of cardiac muscle cell myoblast differentiation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] is_a: GO:0045662 ! negative regulation of myoblast differentiation is_a: GO:0051892 ! negative regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation @@ -31043,6 +40369,7 @@ relationship: RO:0002212 GO:0060379 ! negatively regulates cardiac muscle cell m [Term] id: GO:2000700 name: positive regulation of cardiac muscle cell myoblast differentiation +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] is_a: GO:0045663 ! positive regulation of myoblast differentiation is_a: GO:0051891 ! positive regulation of cardioblast differentiation is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation @@ -31053,6 +40380,7 @@ relationship: RO:0002213 GO:0060379 ! positively regulates cardiac muscle cell m [Term] id: GO:2000725 name: regulation of cardiac muscle cell differentiation +def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] is_a: GO:0051153 ! regulation of striated muscle cell differentiation is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0065007 ! biological regulation @@ -31062,6 +40390,7 @@ relationship: RO:0002211 GO:0055007 ! regulates cardiac muscle cell differentiat [Term] id: GO:2000726 name: negative regulation of cardiac muscle cell differentiation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation @@ -31072,6 +40401,7 @@ relationship: RO:0002212 GO:0055007 ! negatively regulates cardiac muscle cell d [Term] id: GO:2000727 name: positive regulation of cardiac muscle cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation @@ -31082,6 +40412,7 @@ relationship: RO:0002213 GO:0055007 ! positively regulates cardiac muscle cell d [Term] id: GO:2000736 name: regulation of stem cell differentiation +def: "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0048863 ! regulates stem cell differentiation @@ -31090,6 +40421,7 @@ relationship: RO:0002211 GO:0048863 ! regulates stem cell differentiation [Term] id: GO:2000737 name: negative regulation of stem cell differentiation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31099,6 +40431,7 @@ relationship: RO:0002212 GO:0048863 ! negatively regulates stem cell differentia [Term] id: GO:2000738 name: positive regulation of stem cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2000736 ! regulation of stem cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31108,6 +40441,7 @@ relationship: RO:0002213 GO:0048863 ! positively regulates stem cell differentia [Term] id: GO:2000790 name: regulation of mesenchymal cell proliferation involved in lung development +def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation involved in lung development @@ -31116,6 +40450,7 @@ relationship: RO:0002211 GO:0060916 ! regulates mesenchymal cell proliferation i [Term] id: GO:2000791 name: negative regulation of mesenchymal cell proliferation involved in lung development +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation @@ -31127,6 +40462,7 @@ relationship: RO:0002212 GO:0060916 ! negatively regulates mesenchymal cell prol [Term] id: GO:2000792 name: positive regulation of mesenchymal cell proliferation involved in lung development +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process @@ -31138,6 +40474,7 @@ relationship: RO:0002213 GO:0060916 ! positively regulates mesenchymal cell prol [Term] id: GO:2000794 name: regulation of epithelial cell proliferation involved in lung morphogenesis +def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050678 ! regulation of epithelial cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation involved in lung morphogenesis @@ -31146,6 +40483,7 @@ relationship: RO:0002211 GO:0060502 ! regulates epithelial cell proliferation in [Term] id: GO:2000795 name: negative regulation of epithelial cell proliferation involved in lung morphogenesis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] is_a: GO:0050680 ! negative regulation of epithelial cell proliferation is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis intersection_of: GO:0065007 ! biological regulation @@ -31155,6 +40493,7 @@ relationship: RO:0002212 GO:0060502 ! negatively regulates epithelial cell proli [Term] id: GO:2000818 name: negative regulation of myoblast proliferation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation." [GOC:obol] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:2000291 ! regulation of myoblast proliferation intersection_of: GO:0065007 ! biological regulation @@ -31164,6 +40503,7 @@ relationship: RO:0002212 GO:0051450 ! negatively regulates myoblast proliferatio [Term] id: GO:2000826 name: regulation of heart morphogenesis +def: "Any process that modulates the frequency, rate or extent of heart morphogenesis." [GOC:BHF] is_a: GO:2000027 ! regulation of animal organ morphogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0003007 ! regulates heart morphogenesis @@ -31172,6 +40512,7 @@ relationship: RO:0002211 GO:0003007 ! regulates heart morphogenesis [Term] id: GO:2000831 name: regulation of steroid hormone secretion +def: "Any process that modulates the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion @@ -31182,6 +40523,7 @@ relationship: RO:0002211 GO:0035929 ! regulates steroid hormone secretion [Term] id: GO:2000832 name: negative regulation of steroid hormone secretion +def: "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process @@ -31193,6 +40535,7 @@ relationship: RO:0002212 GO:0035929 ! negatively regulates steroid hormone secre [Term] id: GO:2000833 name: positive regulation of steroid hormone secretion +def: "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." [GOC:sl] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process @@ -31204,6 +40547,7 @@ relationship: RO:0002213 GO:0035929 ! positively regulates steroid hormone secre [Term] id: GO:2000834 name: regulation of androgen secretion +def: "Any process that modulates the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000831 ! regulation of steroid hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035935 ! regulates androgen secretion @@ -31212,6 +40556,7 @@ relationship: RO:0002211 GO:0035935 ! regulates androgen secretion [Term] id: GO:2000835 name: negative regulation of androgen secretion +def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0065007 ! biological regulation @@ -31221,15 +40566,26 @@ relationship: RO:0002212 GO:0035935 ! negatively regulates androgen secretion [Term] id: GO:2000836 name: positive regulation of androgen secretion +def: "Any process that activates or increases the frequency, rate or extent of androgen secretion." [GOC:sl] is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000834 ! regulation of androgen secretion intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002213 GO:0035935 ! positively regulates androgen secretion relationship: RO:0002213 GO:0035935 ! positively regulates androgen secretion +[Term] +id: GO:2001012 +name: mesenchymal cell differentiation involved in renal system development +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +is_a: GO:0048762 ! mesenchymal cell differentiation +intersection_of: GO:0048762 ! mesenchymal cell differentiation +intersection_of: BFO:0000050 GO:0072001 ! part of renal system development +relationship: BFO:0000050 GO:0072001 ! part of renal system development + [Term] id: GO:2001014 name: regulation of skeletal muscle cell differentiation +def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentiation @@ -31238,6 +40594,7 @@ relationship: RO:0002211 GO:0035914 ! regulates skeletal muscle cell differentia [Term] id: GO:2001015 name: negative regulation of skeletal muscle cell differentiation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31247,6 +40604,7 @@ relationship: RO:0002212 GO:0035914 ! negatively regulates skeletal muscle cell [Term] id: GO:2001016 name: positive regulation of skeletal muscle cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31256,6 +40614,7 @@ relationship: RO:0002213 GO:0035914 ! positively regulates skeletal muscle cell [Term] id: GO:2001026 name: regulation of endothelial cell chemotaxis +def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation @@ -31265,6 +40624,7 @@ relationship: RO:0002211 GO:0035767 ! regulates endothelial cell chemotaxis [Term] id: GO:2001027 name: negative regulation of endothelial cell chemotaxis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010596 ! negative regulation of endothelial cell migration is_a: GO:0050922 ! negative regulation of chemotaxis is_a: GO:2001026 ! regulation of endothelial cell chemotaxis @@ -31275,6 +40635,7 @@ relationship: RO:0002212 GO:0035767 ! negatively regulates endothelial cell chem [Term] id: GO:2001028 name: positive regulation of endothelial cell chemotaxis +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] is_a: GO:0010595 ! positive regulation of endothelial cell migration is_a: GO:0050921 ! positive regulation of chemotaxis is_a: GO:2001026 ! regulation of endothelial cell chemotaxis @@ -31285,6 +40646,7 @@ relationship: RO:0002213 GO:0035767 ! positively regulates endothelial cell chem [Term] id: GO:2001053 name: regulation of mesenchymal cell apoptotic process +def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097152 ! regulates mesenchymal cell apoptotic process @@ -31293,6 +40655,7 @@ relationship: RO:0002211 GO:0097152 ! regulates mesenchymal cell apoptotic proce [Term] id: GO:2001054 name: negative regulation of mesenchymal cell apoptotic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -31302,6 +40665,7 @@ relationship: RO:0002212 GO:0097152 ! negatively regulates mesenchymal cell apop [Term] id: GO:2001055 name: positive regulation of mesenchymal cell apoptotic process +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -31311,6 +40675,7 @@ relationship: RO:0002213 GO:0097152 ! positively regulates mesenchymal cell apop [Term] id: GO:2001141 name: regulation of RNA biosynthetic process +def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0032774 ! regulates RNA biosynthetic process @@ -31319,6 +40684,7 @@ relationship: RO:0002211 GO:0032774 ! regulates RNA biosynthetic process [Term] id: GO:2001198 name: regulation of dendritic cell differentiation +def: "Any process that modulates the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902105 ! regulation of leukocyte differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0097028 ! regulates dendritic cell differentiation @@ -31327,6 +40693,7 @@ relationship: RO:0002211 GO:0097028 ! regulates dendritic cell differentiation [Term] id: GO:2001199 name: negative regulation of dendritic cell differentiation +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902106 ! negative regulation of leukocyte differentiation is_a: GO:2001198 ! regulation of dendritic cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31336,6 +40703,7 @@ relationship: RO:0002212 GO:0097028 ! negatively regulates dendritic cell differ [Term] id: GO:2001200 name: positive regulation of dendritic cell differentiation +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] is_a: GO:1902107 ! positive regulation of leukocyte differentiation is_a: GO:2001198 ! regulation of dendritic cell differentiation intersection_of: GO:0065007 ! biological regulation @@ -31345,6 +40713,7 @@ relationship: RO:0002213 GO:0097028 ! positively regulates dendritic cell differ [Term] id: GO:2001204 name: regulation of osteoclast development +def: "Any process that modulates the frequency, rate or extent of osteoclast development." [GOC:obol] is_a: GO:1903706 ! regulation of hemopoiesis intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0036035 ! regulates osteoclast development @@ -31353,6 +40722,7 @@ relationship: RO:0002211 GO:0036035 ! regulates osteoclast development [Term] id: GO:2001205 name: negative regulation of osteoclast development +def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development." [GOC:obol] is_a: GO:0045671 ! negative regulation of osteoclast differentiation is_a: GO:2001204 ! regulation of osteoclast development intersection_of: GO:0065007 ! biological regulation @@ -31362,6 +40732,7 @@ relationship: RO:0002212 GO:0036035 ! negatively regulates osteoclast developmen [Term] id: GO:2001206 name: positive regulation of osteoclast development +def: "Any process that activates or increases the frequency, rate or extent of osteoclast development." [GOC:obol] is_a: GO:0045672 ! positive regulation of osteoclast differentiation is_a: GO:2001204 ! regulation of osteoclast development intersection_of: GO:0065007 ! biological regulation @@ -31371,6 +40742,7 @@ relationship: RO:0002213 GO:0036035 ! positively regulates osteoclast developmen [Term] id: GO:2001212 name: regulation of vasculogenesis +def: "Any process that modulates the frequency, rate or extent of vasculogenesis." [GOC:obol] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001570 ! regulates vasculogenesis @@ -31379,6 +40751,7 @@ relationship: RO:0002211 GO:0001570 ! regulates vasculogenesis [Term] id: GO:2001213 name: negative regulation of vasculogenesis +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis." [GOC:obol] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0065007 ! biological regulation @@ -31388,6 +40761,7 @@ relationship: RO:0002212 GO:0001570 ! negatively regulates vasculogenesis [Term] id: GO:2001214 name: positive regulation of vasculogenesis +def: "Any process that activates or increases the frequency, rate or extent of vasculogenesis." [GOC:obol] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:2001212 ! regulation of vasculogenesis intersection_of: GO:0065007 ! biological regulation @@ -31397,6 +40771,7 @@ relationship: RO:0002213 GO:0001570 ! positively regulates vasculogenesis [Term] id: GO:2001222 name: regulation of neuron migration +def: "Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol] is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: RO:0002211 GO:0001764 ! regulates neuron migration @@ -31407,6 +40782,7 @@ relationship: RO:0002211 GO:0001764 ! regulates neuron migration [Term] id: GO:2001223 name: negative regulation of neuron migration +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration." [GOC:obol] is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0065007 ! biological regulation @@ -31416,6 +40792,7 @@ relationship: RO:0002212 GO:0001764 ! negatively regulates neuron migration [Term] id: GO:2001224 name: positive regulation of neuron migration +def: "Any process that activates or increases the frequency, rate or extent of neuron migration." [GOC:obol] is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:2001222 ! regulation of neuron migration intersection_of: GO:0065007 ! biological regulation @@ -31425,6 +40802,7 @@ relationship: RO:0002213 GO:0001764 ! positively regulates neuron migration [Term] id: GO:2001233 name: regulation of apoptotic signaling pathway +def: "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0042981 ! regulation of apoptotic process intersection_of: GO:0065007 ! biological regulation @@ -31434,6 +40812,7 @@ relationship: RO:0002211 GO:0097190 ! regulates apoptotic signaling pathway [Term] id: GO:2001234 name: negative regulation of apoptotic signaling pathway +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway @@ -31444,6 +40823,7 @@ relationship: RO:0002212 GO:0097190 ! negatively regulates apoptotic signaling p [Term] id: GO:2001235 name: positive regulation of apoptotic signaling pathway +def: "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:2001233 ! regulation of apoptotic signaling pathway @@ -31454,6 +40834,7 @@ relationship: RO:0002213 GO:0097190 ! positively regulates apoptotic signaling p [Term] id: GO:2001251 name: negative regulation of chromosome organization +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation @@ -31463,6 +40844,7 @@ relationship: RO:0002212 GO:0051276 ! negatively regulates chromosome organizati [Term] id: GO:2001252 name: positive regulation of chromosome organization +def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation @@ -31472,448 +40854,730 @@ relationship: RO:0002213 GO:0051276 ! positively regulates chromosome organizati [Term] id: NCBITaxon:1 name: root +xref: GC_ID:1 +xref: PMID:30365038 +xref: PMID:32761142 [Term] id: NCBITaxon:117570 name: Teleostomi +xref: GC_ID:1 is_a: NCBITaxon:7776 ! Gnathostomata [Term] id: NCBITaxon:117571 name: Euteleostomi +xref: GC_ID:1 is_a: NCBITaxon:117570 ! Teleostomi [Term] id: NCBITaxon:1206794 name: Ecdysozoa +xref: GC_ID:1 is_a: NCBITaxon:33317 ! Protostomia [Term] id: NCBITaxon:131209 name: Zygnemophyceae +xref: GC_ID:1 is_a: NCBITaxon:131221 ! Streptophytina [Term] id: NCBITaxon:131221 name: Streptophytina +xref: GC_ID:1 is_a: NCBITaxon:35493 ! Streptophyta [Term] id: NCBITaxon:131567 name: cellular organisms +xref: GC_ID:1 is_a: NCBITaxon:1 ! root [Term] id: NCBITaxon:1329799 name: Archelosauria +xref: GC_ID:1 +xref: PMID:22839753 +xref: PMID:25450099 is_a: NCBITaxon:32561 ! Sauria [Term] id: NCBITaxon:1338369 name: Dipnotetrapodomorpha +xref: GC_ID:1 is_a: NCBITaxon:8287 ! Sarcopterygii [Term] id: NCBITaxon:142796 name: Eumycetozoa +xref: GC_ID:1 +xref: PMID:11062127 +xref: PMID:9342353 is_a: NCBITaxon:2605435 ! Evosea +[Term] +id: NCBITaxon:1437010 +name: Boreoeutheria +xref: GC_ID:1 +xref: PMID:11743200 +xref: PMID:11791233 +is_a: NCBITaxon:9347 ! Eutheria + [Term] id: NCBITaxon:1437180 name: Acrogymnospermae +xref: GC_ID:1 is_a: NCBITaxon:58024 ! Spermatophyta [Term] id: NCBITaxon:1445966 name: Gnetidae +xref: GC_ID:1 is_a: NCBITaxon:3372 ! Gnetopsida [Term] id: NCBITaxon:147537 name: Saccharomycotina +xref: GC_ID:1 is_a: NCBITaxon:716545 ! saccharomyceta [Term] id: NCBITaxon:147554 name: Schizosaccharomycetes +xref: GC_ID:1 is_a: NCBITaxon:451866 ! Taphrinomycotina [Term] id: NCBITaxon:186623 name: Actinopteri +xref: GC_ID:1 is_a: NCBITaxon:7898 ! Actinopterygii [Term] id: NCBITaxon:197562 name: Pancrustacea +xref: GC_ID:1 +xref: PMID:10874751 +xref: PMID:11557979 is_a: NCBITaxon:197563 ! Mandibulata [Term] id: NCBITaxon:197563 name: Mandibulata +xref: GC_ID:1 +xref: PMID:11557979 +xref: PMID:9727836 is_a: NCBITaxon:6656 ! Arthropoda [Term] id: NCBITaxon:2 name: Bacteria +xref: GC_ID:11 +xref: PMID:10425795 +xref: PMID:10425796 +xref: PMID:10425797 +xref: PMID:10490293 +xref: PMID:10843050 +xref: PMID:10939651 +xref: PMID:10939673 +xref: PMID:10939677 +xref: PMID:11211268 +xref: PMID:11321083 +xref: PMID:11321113 +xref: PMID:11411719 +xref: PMID:11540071 +xref: PMID:11542017 +xref: PMID:11542087 +xref: PMID:11760965 +xref: PMID:12054223 +xref: PMID:2112744 +xref: PMID:270744 +xref: PMID:32628106 +xref: PMID:36748408 +xref: PMID:7520741 +xref: PMID:8123559 +xref: PMID:8186100 +xref: PMID:8590690 +xref: PMID:9103655 +xref: PMID:9336922 is_a: NCBITaxon:131567 ! cellular organisms [Term] id: NCBITaxon:2058185 name: Dictyosteliaceae +xref: GC_ID:1 +xref: PMID:29367151 is_a: NCBITaxon:2058949 ! Dictyosteliales [Term] id: NCBITaxon:2058949 name: Dictyosteliales +xref: GC_ID:1 +xref: PMID:29367151 is_a: NCBITaxon:33083 ! Dictyostelia +[Term] +id: NCBITaxon:207598 +name: Homininae +xref: GC_ID:1 +is_a: NCBITaxon:9604 ! Hominidae + [Term] id: NCBITaxon:2157 name: Archaea +xref: GC_ID:11 +xref: PMID:10425795 +xref: PMID:10425796 +xref: PMID:10425797 +xref: PMID:10490293 +xref: PMID:10843050 +xref: PMID:10939651 +xref: PMID:10939673 +xref: PMID:10939677 +xref: PMID:11211268 +xref: PMID:11321083 +xref: PMID:11321113 +xref: PMID:11411719 +xref: PMID:11540071 +xref: PMID:11541975 +xref: PMID:11542064 +xref: PMID:11542149 +xref: PMID:11760965 +xref: PMID:12054223 +xref: PMID:2112744 +xref: PMID:25527841 +xref: PMID:270744 +xref: PMID:32628106 +xref: PMID:36748408 +xref: PMID:8123559 +xref: PMID:8590690 +xref: PMID:9103655 +xref: PMID:9336922 is_a: NCBITaxon:131567 ! cellular organisms [Term] id: NCBITaxon:2605435 name: Evosea +xref: GC_ID:1 is_a: NCBITaxon:554915 ! Amoebozoa [Term] id: NCBITaxon:2611352 name: Discoba +xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:2684882 name: Zygnematophycidae +xref: GC_ID:1 is_a: NCBITaxon:131209 ! Zygnemophyceae [Term] id: NCBITaxon:2698737 name: Sar +xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:2759 name: Eukaryota +xref: GC_ID:1 +xref: PMID:23020233 +xref: PMID:30257078 is_a: NCBITaxon:131567 ! cellular organisms +[Term] +id: NCBITaxon:314146 +name: Euarchontoglires +xref: GC_ID:1 +xref: PMID:11214319 +xref: PMID:12082125 +xref: PMID:12878460 +xref: PMID:15522813 +is_a: NCBITaxon:1437010 ! Boreoeutheria + +[Term] +id: NCBITaxon:314293 +name: Simiiformes +xref: GC_ID:1 +is_a: NCBITaxon:376913 ! Haplorrhini + +[Term] +id: NCBITaxon:314295 +name: Hominoidea +xref: GC_ID:1 +is_a: NCBITaxon:9526 ! Catarrhini + [Term] id: NCBITaxon:3176 name: Zygnematales +xref: GC_ID:1 is_a: NCBITaxon:2684882 ! Zygnematophycidae [Term] id: NCBITaxon:3193 name: Embryophyta +xref: GC_ID:1 is_a: NCBITaxon:131221 ! Streptophytina [Term] id: NCBITaxon:32443 name: Teleostei +xref: GC_ID:1 is_a: NCBITaxon:41665 ! Neopterygii [Term] id: NCBITaxon:32523 name: Tetrapoda +xref: GC_ID:1 is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha [Term] id: NCBITaxon:32524 name: Amniota +xref: GC_ID:1 is_a: NCBITaxon:32523 ! Tetrapoda [Term] id: NCBITaxon:32525 name: Theria +xref: GC_ID:1 is_a: NCBITaxon:40674 ! Mammalia [Term] id: NCBITaxon:32561 name: Sauria +xref: GC_ID:1 is_a: NCBITaxon:8457 ! Sauropsida [Term] id: NCBITaxon:33083 name: Dictyostelia +xref: GC_ID:1 +xref: PMID:11062127 +xref: PMID:29367151 +xref: PMID:9342353 is_a: NCBITaxon:142796 ! Eumycetozoa [Term] id: NCBITaxon:33090 name: Viridiplantae +xref: GC_ID:1 +xref: PMID:16248873 +xref: PMID:30257078 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:3312 name: Coniferophyta +xref: GC_ID:1 is_a: NCBITaxon:1437180 ! Acrogymnospermae [Term] id: NCBITaxon:33154 name: Opisthokonta +xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:33208 name: Metazoa +xref: GC_ID:1 is_a: NCBITaxon:33154 ! Opisthokonta [Term] id: NCBITaxon:33213 name: Bilateria +xref: GC_ID:1 is_a: NCBITaxon:6072 ! Eumetazoa [Term] id: NCBITaxon:33317 name: Protostomia +xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria [Term] id: NCBITaxon:33511 name: Deuterostomia +xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria [Term] id: NCBITaxon:33630 name: Alveolata +xref: GC_ID:1 is_a: NCBITaxon:2698737 ! Sar [Term] id: NCBITaxon:33682 name: Euglenozoa +xref: GC_ID:1 is_a: NCBITaxon:2611352 ! Discoba [Term] id: NCBITaxon:3372 name: Gnetopsida +xref: GC_ID:1 is_a: NCBITaxon:1437180 ! Acrogymnospermae [Term] id: NCBITaxon:3378 name: Gnetales +xref: GC_ID:1 is_a: NCBITaxon:1445966 ! Gnetidae [Term] id: NCBITaxon:3398 name: Magnoliopsida +xref: GC_ID:1 +xref: PMID:25249442 is_a: NCBITaxon:58024 ! Spermatophyta [Term] id: NCBITaxon:34346 name: Schizosaccharomycetales +xref: GC_ID:1 is_a: NCBITaxon:147554 ! Schizosaccharomycetes [Term] id: NCBITaxon:35493 name: Streptophyta +xref: GC_ID:1 is_a: NCBITaxon:33090 ! Viridiplantae +[Term] +id: NCBITaxon:376913 +name: Haplorrhini +xref: GC_ID:1 +is_a: NCBITaxon:9443 ! Primates + [Term] id: NCBITaxon:38254 name: Glaucocystophyceae +xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:40674 name: Mammalia +xref: GC_ID:1 is_a: NCBITaxon:32524 ! Amniota [Term] id: NCBITaxon:41665 name: Neopterygii +xref: GC_ID:1 is_a: NCBITaxon:186623 ! Actinopteri [Term] id: NCBITaxon:436486 name: Dinosauria +xref: GC_ID:1 is_a: NCBITaxon:8492 ! Archosauria [Term] id: NCBITaxon:436489 name: Saurischia +xref: GC_ID:1 is_a: NCBITaxon:436486 ! Dinosauria [Term] id: NCBITaxon:436491 name: Theropoda +xref: GC_ID:1 is_a: NCBITaxon:436489 ! Saurischia [Term] id: NCBITaxon:436492 name: Coelurosauria +xref: GC_ID:1 is_a: NCBITaxon:436491 ! Theropoda [Term] id: NCBITaxon:451864 name: Dikarya +xref: GC_ID:1 +xref: PMID:15689432 +xref: PMID:16151185 +xref: PMID:17010206 +xref: PMID:17051209 +xref: PMID:17572334 is_a: NCBITaxon:4751 ! Fungi [Term] id: NCBITaxon:451866 name: Taphrinomycotina +xref: GC_ID:1 is_a: NCBITaxon:4890 ! Ascomycota [Term] id: NCBITaxon:4751 name: Fungi +xref: GC_ID:1 +xref: PMID:11062127 +xref: PMID:12684019 is_a: NCBITaxon:33154 ! Opisthokonta [Term] id: NCBITaxon:4890 name: Ascomycota +xref: GC_ID:1 +xref: PMID:17572334 is_a: NCBITaxon:451864 ! Dikarya [Term] id: NCBITaxon:4891 name: Saccharomycetes +xref: GC_ID:1 is_a: NCBITaxon:147537 ! Saccharomycotina [Term] id: NCBITaxon:4892 name: Saccharomycetales +xref: GC_ID:1 is_a: NCBITaxon:4891 ! Saccharomycetes [Term] id: NCBITaxon:4893 name: Saccharomycetaceae +xref: GC_ID:1 is_a: NCBITaxon:4892 ! Saccharomycetales [Term] id: NCBITaxon:4894 name: Schizosaccharomycetaceae +xref: GC_ID:1 is_a: NCBITaxon:34346 ! Schizosaccharomycetales [Term] id: NCBITaxon:4895 name: Schizosaccharomyces +xref: GC_ID:1 is_a: NCBITaxon:4894 ! Schizosaccharomycetaceae [Term] id: NCBITaxon:4896 name: Schizosaccharomyces pombe +xref: GC_ID:1 is_a: NCBITaxon:4895 ! Schizosaccharomyces [Term] id: NCBITaxon:4930 name: Saccharomyces +xref: GC_ID:1 is_a: NCBITaxon:4893 ! Saccharomycetaceae [Term] id: NCBITaxon:4932 name: Saccharomyces cerevisiae +xref: GC_ID:1 is_a: NCBITaxon:4930 ! Saccharomyces [Term] id: NCBITaxon:50557 name: Insecta +xref: GC_ID:1 is_a: NCBITaxon:6960 ! Hexapoda [Term] id: NCBITaxon:554915 name: Amoebozoa +xref: GC_ID:1 +xref: PMID:23020233 +xref: PMID:30257078 is_a: NCBITaxon:2759 ! Eukaryota [Term] id: NCBITaxon:5782 name: Dictyostelium +xref: GC_ID:1 +xref: PMID:29367151 is_a: NCBITaxon:2058185 ! Dictyosteliaceae [Term] id: NCBITaxon:58023 name: Tracheophyta +xref: GC_ID:1 is_a: NCBITaxon:3193 ! Embryophyta [Term] id: NCBITaxon:58024 name: Spermatophyta +xref: GC_ID:1 is_a: NCBITaxon:78536 ! Euphyllophyta [Term] id: NCBITaxon:6072 name: Eumetazoa +xref: GC_ID:1 is_a: NCBITaxon:33208 ! Metazoa [Term] id: NCBITaxon:6656 name: Arthropoda +xref: GC_ID:1 is_a: NCBITaxon:88770 ! Panarthropoda [Term] id: NCBITaxon:6960 name: Hexapoda +xref: GC_ID:1 is_a: NCBITaxon:197562 ! Pancrustacea [Term] id: NCBITaxon:716545 name: saccharomyceta +xref: GC_ID:1 is_a: NCBITaxon:4890 ! Ascomycota [Term] id: NCBITaxon:7711 name: Chordata +xref: GC_ID:1 is_a: NCBITaxon:33511 ! Deuterostomia [Term] id: NCBITaxon:7742 name: Vertebrata +xref: GC_ID:1 is_a: NCBITaxon:89593 ! Craniata [Term] id: NCBITaxon:7776 name: Gnathostomata +xref: GC_ID:1 is_a: NCBITaxon:7742 ! Vertebrata [Term] id: NCBITaxon:78536 name: Euphyllophyta +xref: GC_ID:1 is_a: NCBITaxon:58023 ! Tracheophyta [Term] id: NCBITaxon:7898 name: Actinopterygii +xref: GC_ID:1 is_a: NCBITaxon:117571 ! Euteleostomi [Term] id: NCBITaxon:8287 name: Sarcopterygii +xref: GC_ID:1 is_a: NCBITaxon:117571 ! Euteleostomi [Term] id: NCBITaxon:8457 name: Sauropsida +xref: GC_ID:1 is_a: NCBITaxon:32524 ! Amniota [Term] id: NCBITaxon:8492 name: Archosauria +xref: GC_ID:1 is_a: NCBITaxon:1329799 ! Archelosauria [Term] id: NCBITaxon:8782 name: Aves +xref: GC_ID:1 is_a: NCBITaxon:436492 ! Coelurosauria [Term] id: NCBITaxon:88770 name: Panarthropoda +xref: GC_ID:1 is_a: NCBITaxon:1206794 ! Ecdysozoa [Term] id: NCBITaxon:89593 name: Craniata +xref: GC_ID:1 is_a: NCBITaxon:7711 ! Chordata +[Term] +id: NCBITaxon:9347 +name: Eutheria +xref: GC_ID:1 +is_a: NCBITaxon:32525 ! Theria + +[Term] +id: NCBITaxon:9443 +name: Primates +xref: GC_ID:1 +is_a: NCBITaxon:314146 ! Euarchontoglires + +[Term] +id: NCBITaxon:9526 +name: Catarrhini +xref: GC_ID:1 +is_a: NCBITaxon:314293 ! Simiiformes + +[Term] +id: NCBITaxon:9604 +name: Hominidae +xref: GC_ID:1 +is_a: NCBITaxon:314295 ! Hominoidea + +[Term] +id: NCBITaxon:9605 +name: Homo +xref: GC_ID:1 +is_a: NCBITaxon:207598 ! Homininae + +[Term] +id: NCBITaxon:9606 +name: Homo sapiens +xref: GC_ID:1 +is_a: NCBITaxon:9605 ! Homo + +[Term] +id: SO:0000001 +name: region +def: "A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids." [SO:ke] +is_a: SO:0000110 ! sequence_feature + +[Term] +id: SO:0000110 +name: sequence_feature +def: "Any extent of continuous biological sequence." [LAMHDI:mb, SO:ke] + +[Term] +id: SO:0000704 +name: gene +def: "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions." [SO:immuno_workshop] +comment: This term is mapped to MGED. Do not obsolete without consulting MGED ontology. A gene may be considered as a unit of inheritance. +xref: http://en.wikipedia.org/wiki/Gene "wiki" +is_a: SO:0001411 ! biological_region +relationship: member_of SO:0005855 ! gene_group + [Term] id: SO:0001260 name: sequence_collection +def: "A collection of discontinuous sequences." [SO:ke] + +[Term] +id: SO:0001411 +name: biological_region +def: "A region defined by its disposition to be involved in a biological process." [SO:cb] +is_a: SO:0000001 ! region + +[Term] +id: SO:0005855 +name: gene_group +def: "A collection of related genes." [SO:ma] +is_a: SO:0001411 ! biological_region [Term] id: UBERON:0000000 name: processual entity +def: "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity." [span:ProcessualEntity] +xref: BFO:0000003 disjoint_from: UBERON:0001062 ! anatomical entity -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000005 @@ -31925,9 +41589,44 @@ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000050 UBERON:0005726 ! part of chemosensory system relationship: RO:0002215 GO:0007606 ! capable of sensory perception of chemical stimulus +[Term] +id: UBERON:0000006 +name: islet of Langerhans +def: "The clusters of hormone-producing cells that are scattered throughout the pancreas." [MA:0000127, MESH:A03.734.414, MP:0005215] +xref: AAO:0010406 +xref: BTO:0000991 +xref: CALOHA:TS-0741 +xref: EFO:0000856 +xref: EMAPA:32927 +xref: EV:0100130 +xref: FMA:16016 +xref: GAID:324 +xref: MA:0000127 +xref: MAT:0000076 +xref: MESH:D007515 +xref: MIAA:0000076 +xref: NCIT:C12608 +xref: VHOG:0000646 +xref: Wikipedia:Islets_of_Langerhans +xref: XAO:0000159 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0034922 ! cell cluster +relationship: BFO:0000050 UBERON:0000016 ! part of endocrine pancreas +relationship: BFO:0000051 CL:0000168 ! has part insulin secreting cell +relationship: BFO:0000051 CL:0000172 ! has part somatostatin secreting cell +relationship: BFO:0000051 CL:0002067 ! has part type A enteroendocrine cell +relationship: RO:0002433 UBERON:0000016 ! endocrine pancreas + [Term] id: UBERON:0000009 name: submucosa +def: "A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]." [Wikipedia:Submucosa] +xref: BTO:0002107 +xref: FMA:85391 +xref: FMA:85392 +xref: NCIT:C13167 +xref: SCTID:68439008 +xref: Wikipedia:Submucosa is_a: UBERON:0004923 ! organ component layer relationship: BSPO:0001107 UBERON:0000344 ! mucosa relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -31936,13 +41635,58 @@ relationship: RO:0002473 UBERON:0002384 ! connective tissue [Term] id: UBERON:0000010 name: peripheral nervous system +def: "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GO:0007422] +xref: AAO:0000429 +xref: BAMS:PNS +xref: BILA:0000081 +xref: BIRNLEX:1111 +xref: BTO:0001028 +xref: CALOHA:TS-0808 +xref: EFO:0000891 +xref: EHDAA2:0001445 +xref: EHDAA:2893 +xref: EMAPA:16665 +xref: EV:0100335 +xref: FMA:9903 +xref: GAID:715 +xref: MA:0000218 +xref: MAT:0000338 +xref: MESH:D017933 +xref: MIAA:0000338 +xref: NCIT:C12465 +xref: neuronames:3232 +xref: SCTID:362292005 +xref: TAO:0000142 +xref: VHOG:0000399 +xref: Wikipedia:Peripheral_nervous_system +xref: XAO:0000178 +xref: ZFA:0000142 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0001016 ! part of nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000013 name: sympathetic nervous system +def: "The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]." [GO:0048485] +xref: AAO:0010487 +xref: BIRNLEX:2516 +xref: BTO:0001832 +xref: CALOHA:TS-2050 +xref: EFO:0000893 +xref: EHDAA2:0001971 +xref: EHDAA:3769 +xref: EMAPA:16985 +xref: FMA:9906 +xref: GAID:710 +xref: MA:0000225 +xref: MESH:D013564 +xref: MIAA:0000100 +xref: NCIT:C12795 +xref: SCTID:362484004 +xref: TAO:0001576 +xref: VHOG:0000384 +xref: Wikipedia:Sympathetic_nervous_system +xref: ZFA:0001576 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: RO:0002433 UBERON:0002410 ! autonomic nervous system @@ -31950,6 +41694,18 @@ relationship: RO:0002433 UBERON:0002410 ! autonomic nervous system [Term] id: UBERON:0000014 name: zone of skin +def: "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Skin] +xref: EHDAA:6530 +xref: EV:0100152 +xref: FMA:86166 +xref: GAID:933 +xref: MA:0000151 +xref: MAT:0000284 +xref: MESH:D012867 +xref: MIAA:0000284 +xref: SCTID:20795001 +xref: VHOG:0000860 +xref: Wikipedia:Skin is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034944 ! zone of organ relationship: BFO:0000050 UBERON:0002097 ! part of skin of body @@ -31959,14 +41715,78 @@ relationship: BFO:0000051 UBERON:0002067 ! has part dermis [Term] id: UBERON:0000015 name: non-material anatomical boundary +def: "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." [CARO:0000010] +comment: Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. +xref: AEO:0000192 +xref: CARO:0000010 +xref: FMA:50705 is_a: UBERON:0000466 ! immaterial anatomical entity -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 + +[Term] +id: UBERON:0000016 +name: endocrine pancreas +def: "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin." [GO:GO, http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000650 +xref: CALOHA:TS-1302 +xref: EFO:0002542 +xref: EMAPA:35305 +xref: EV:0100129 +xref: FMA:16018 +xref: MA:0001582 +xref: NCIT:C32509 +xref: SCTID:361339003 +xref: TAO:0001260 +xref: VHOG:0000049 +xref: Wikipedia:Islets_of_Langerhans +xref: ZFA:0001260 +is_a: UBERON:0000471 ! compound organ component +is_a: UBERON:0004119 ! endoderm-derived structure +relationship: BFO:0000050 UBERON:0000949 ! part of endocrine system +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: RO:0002202 UBERON:0003923 ! dorsal pancreatic bud +relationship: RO:0002215 GO:0030073 ! capable of insulin secretion +relationship: RO:0002215 GO:0070091 ! capable of glucagon secretion +relationship: RO:0002215 GO:0070253 ! capable of somatostatin secretion +relationship: RO:0002433 UBERON:0001264 ! pancreas +relationship: RO:0002473 UBERON:0000006 ! islet of Langerhans + +[Term] +id: UBERON:0000017 +name: exocrine pancreas +def: "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]." [GOC:GO, http://orcid.org/0000-0002-6601-2165] +xref: AAO:0010407 +xref: BTO:0000434 +xref: CALOHA:TS-1241 +xref: EMAPA:35328 +xref: EV:0100093 +xref: FMA:16017 +xref: MA:0002415 +xref: NCIT:C32546 +xref: SCTID:248202004 +xref: TAO:0001249 +xref: VHOG:0000048 +xref: Wikipedia:Exocrine_component_of_pancreas +xref: XAO:0000137 +xref: ZFA:0001249 +is_a: UBERON:0000409 ! serous gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005177 ! trunk region element +is_a: UBERON:0013765 ! digestive system element +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000051 UBERON:0001263 ! has part pancreatic acinus +relationship: BFO:0000051 UBERON:0007329 ! has part pancreatic duct +relationship: RO:0002202 UBERON:0003924 ! ventral pancreatic bud +relationship: RO:0002216 GO:0007586 ! capable of part of digestion +relationship: RO:0002433 UBERON:0001264 ! pancreas [Term] id: UBERON:0000018 name: compound eye +def: "A light sensing organ composed of ommatidia." [FB:gg, Wikipedia:Compound_eye] +xref: BTO:0001921 +xref: HAO:0000217 +xref: TGMA:0000024 +xref: Wikipedia:Compound_eye is_a: UBERON:0015165 ! multi-unit eye intersection_of: UBERON:0000970 ! eye intersection_of: RO:0002473 UBERON:0000971 ! ommatidium @@ -31976,6 +41796,21 @@ relationship: RO:0002473 UBERON:0000971 ! ommatidium [Term] id: UBERON:0000019 name: camera-type eye +def: "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid." [GO:0043010, https://orcid.org/0000-0002-6601-2165] +xref: AAO:0010340 +xref: BIRNLEX:1169 +xref: BTO:0004688 +xref: EHDAA2:0000484 +xref: EHDAA:936 +xref: EMAPA:16198 +xref: FMA:54448 +xref: MA:0000261 +xref: NCIT:C12401 +xref: SCTID:181143004 +xref: TAO:0000107 +xref: VHOG:0000275 +xref: XAO:0000179 +xref: ZFA:0000107 is_a: UBERON:0000047 ! simple eye is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -31990,6 +41825,22 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0000020 name: sense organ +def: "An organ that is capable of transducing sensory stimulus to the nervous system." [https://github.com/obophenotype/uberon/issues/549, https://orcid.org/0000-0002-6601-2165] +xref: AEO:0000094 +xref: BSA:0000121 +xref: BTO:0000202 +xref: CALOHA:TS-2043 +xref: EHDAA2:0001824 +xref: EHDAA:500 +xref: EMAPA:35955 +xref: GAID:63 +xref: HAO:0000930 +xref: MA:0000017 +xref: MESH:D012679 +xref: NCIT:C33224 +xref: SCTID:244485009 +xref: VHOG:0001407 +xref: WBbt:0006929 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: RO:0002215 GO:0050906 ! capable of detection of stimulus involved in sensory perception @@ -31999,6 +41850,8 @@ relationship: RO:0002215 GO:0050906 ! capable of detection of stimulus involved [Term] id: UBERON:0000025 name: tube +def: "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported." [http://orcid.org/0000-0002-6601-2165] +xref: galen:Tube is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: RO:0000086 PATO:0002299 @@ -32008,12 +41861,34 @@ relationship: RO:0000086 PATO:0002299 [Term] id: UBERON:0000026 name: appendage +def: "Major subdivision of an organism that protrudes from the body[DOS, CARO]." [CARO:DOS] +xref: AEO:0000193 +xref: BILA:0000018 +xref: BTO:0001492 +xref: CARO:0010003 +xref: EFO:0000799 +xref: EHDAA2:0003193 +xref: EV:0100155 +xref: HAO:0000144 +xref: MAT:0000023 +xref: MESH:D005121 +xref: MIAA:0000023 +xref: NCIT:C61460 +xref: VSAO:0000075 +xref: Wikipedia:Appendage +xref: XAO:0000218 is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0000030 name: lamina propria +def: "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions." [Wikipedia:Lamina_propria] +xref: BTO:0002330 +xref: FMA:62517 +xref: NCIT:C32918 +xref: SCTID:298225002 +xref: Wikipedia:Lamina_propria is_a: UBERON:0004923 ! organ component layer relationship: BFO:0000050 UBERON:0000344 ! part of mucosa relationship: BSPO:0001107 UBERON:0000483 ! epithelium @@ -32022,6 +41897,11 @@ relationship: RO:0002473 UBERON:0011825 ! loose connective tissue [Term] id: UBERON:0000031 name: lamina propria of trachea +def: "A lamina propria that is part of a respiratory airway." [OBOL:automatic] +xref: EMAPA:35877 +xref: FMA:265157 +xref: MA:0001858 +xref: NCIT:C49305 is_a: UBERON:0004779 ! respiratory system lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001005 ! part of respiratory airway @@ -32030,6 +41910,34 @@ relationship: BFO:0000050 UBERON:0000379 ! part of tracheal mucosa [Term] id: UBERON:0000033 name: head +def: "The head is the anterior-most division of the body [GO]." [GO:0060322, Wikipedia:Head] +xref: AAO:0010335 +xref: AEO:0000106 +xref: BILA:0000115 +xref: BIRNLEX:1230 +xref: BTO:0000282 +xref: CALOHA:TS-0436 +xref: EFO:0000964 +xref: EHDAA2:0003106 +xref: EMAPA:31858 +xref: FMA:7154 +xref: GAID:61 +xref: galen:Head +xref: HAO:0000397 +xref: MA:0000023 +xref: MAT:0000294 +xref: MESH:D006257 +xref: MIAA:0000294 +xref: NCIT:C12419 +xref: SCTID:302548004 +xref: SPD:0000016 +xref: TAO:0001114 +xref: TGMA:0000002 +xref: VHOG:0001644 +xref: WBbt:0005739 +xref: Wikipedia:Head +xref: XAO:0003024 +xref: ZFA:0001114 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region relationship: RO:0002160 NCBITaxon:33213 ! Bilateria @@ -32038,6 +41946,15 @@ relationship: RO:0002551 UBERON:0003129 {gci_filler="NCBITaxon:7776", gci_relati [Term] id: UBERON:0000042 name: serous membrane +def: "Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Serous_membrane] +xref: FMA:9581 +xref: GAID:19 +xref: MESH:D012704 +xref: NCIT:C13169 +xref: SCTID:362878009 +xref: TAO:0005425 +xref: Wikipedia:Serous_membrane +xref: ZFA:0005425 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000060 ! part of anatomical wall @@ -32047,6 +41964,25 @@ relationship: BFO:0000051 UBERON:0002384 ! has part connective tissue [Term] id: UBERON:0000043 name: tendon +def: "Dense regular connective tissue that connects muscle to bone[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000073, Wikipedia:Tendon] +xref: AEO:0000091 +xref: BTO:0001356 +xref: CALOHA:TS-1021 +xref: EHDAA2:0003091 +xref: EMAPA:35854 +xref: EV:0100149 +xref: FMA:9721 +xref: GAID:276 +xref: galen:Tendon +xref: MA:0000115 +xref: MESH:D013710 +xref: NCIT:C13045 +xref: SCTID:256667004 +xref: VHOG:0001286 +xref: VSAO:0000073 +xref: Wikipedia:Tendon +xref: XAO:0000173 +xref: ZFA:0005647 is_a: UBERON:0007846 ! dense regular connective tissue relationship: BFO:0000050 UBERON:0002204 ! part of musculoskeletal system relationship: BFO:0000051 CL:0000327 ! has part extracellular matrix secreting cell @@ -32057,35 +41993,108 @@ relationship: RO:0002176 UBERON:0001630 ! muscle organ [Term] id: UBERON:0000045 name: ganglion +def: "A biological tissue mass, most commonly a mass of nerve cell bodies." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Ganglion] +xref: AAO:0010426 +xref: AEO:0000135 +xref: BAMS:G +xref: BTO:0000497 +xref: CALOHA:TS-0397 +xref: EFO:0000899 +xref: EHDAA2:0003135 +xref: EHDAA:2897 +xref: EHDAA:4662 +xref: EHDAA:5621 +xref: EHDAA:918 +xref: EMAPA:32846 +xref: EV:0100372 +xref: FMA:5884 +xref: MA:0002406 +xref: MAT:0000207 +xref: MAT:0000343 +xref: MESH:D005724 +xref: MIAA:0000207 +xref: MIAA:0000343 +xref: NCIT:C12719 +xref: NLXANAT:100302 +xref: TAO:0000190 +xref: TGMA:0001016 +xref: VHOG:0000156 +xref: WBbt:0005189 +xref: Wikipedia:Ganglion +xref: XAO:0000209 +xref: ZFA:0000190 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002473 UBERON:0003714 ! neural tissue relationship: RO:0002495 UBERON:0003869 ! presumptive ganglion -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000047 name: simple eye +def: "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity." [Wikipedia:Eye#Simple_eyes] +xref: TGMA:0000729 +xref: Wikipedia:Eye#Simple_eyes is_a: UBERON:0000970 ! eye [Term] id: UBERON:0000055 name: vessel +def: "A tubular structure that contains, conveys body fluid, such as blood or lymph." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0004111 ! anatomical conduit relationship: channel_for UBERON:0006314 ! bodily fluid -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000058 name: duct +def: "A tubular structure that transports secreted or excreted substances." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm#ducts] +xref: AAO:0011123 +xref: FMA:30320 +xref: galen:Duct +xref: NCIT:C12948 +xref: SCTID:91726008 +xref: TAO:0005171 +xref: Wikipedia:Duct_(anatomy) +xref: XAO:0004000 +xref: ZFA:0005171 is_a: UBERON:0000063 ! organ subunit relationship: BFO:0000051 UBERON:0034969 ! has part epithelial layer of duct relationship: RO:0000086 PATO:0002299 relationship: RO:0002570 UBERON:0000463 ! organism substance +[Term] +id: UBERON:0000059 +name: large intestine +def: "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]." [ISBN:0073040584, Wikipedia:Large_intestine_(anatomy)] +xref: AAO:0010396 +xref: BTO:0000706 +xref: CALOHA:TS-1306 +xref: EFO:0000840 +xref: EMAPA:19252 +xref: EV:0100077 +xref: FMA:7201 +xref: GAID:306 +xref: galen:LargeIntestine +xref: MA:0000333 +xref: MESH:D007420 +xref: MIAA:0000046 +xref: NCIT:C12379 +xref: SCTID:181254001 +xref: VHOG:0000054 +xref: Wikipedia:Large_intestine_(anatomy) +xref: XAO:0000131 +is_a: UBERON:0004921 ! subdivision of digestive tract +is_a: UBERON:0013765 ! digestive system element +relationship: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0004907 ! part of lower digestive tract +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002433 UBERON:0000160 ! intestine + [Term] id: UBERON:0000060 name: anatomical wall +def: "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers." [FMA:82482] +xref: FMA:82482 +xref: galen:Wall is_a: UBERON:0000064 ! organ part relationship: BFO:0000051 UBERON:0004923 ! has part organ component layer relationship: RO:0002220 UBERON:0002553 ! adjacent to anatomical cavity @@ -32093,52 +42102,98 @@ relationship: RO:0002220 UBERON:0002553 ! adjacent to anatomical cavity [Term] id: UBERON:0000061 name: anatomical structure +def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." [CARO:0000003] +xref: AAO:0010825 +xref: AEO:0000003 +xref: BILA:0000003 +xref: CARO:0000003 +xref: EHDAA2:0003003 +xref: EMAPA:0 +xref: FMA:305751 +xref: FMA:67135 +xref: GAID:781 +xref: HAO:0000003 +xref: http://dbpedia.org/ontology/AnatomicalStructure +xref: MA:0003000 +xref: MESH:D000825 +xref: SCTID:362889002 +xref: TAO:0000037 +xref: TGMA:0001823 +xref: VHOG:0001759 +xref: XAO:0003000 +xref: ZFA:0000037 is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002496 UBERON:0000106 {gci_filler="NCBITaxon:33208", gci_relation="RO:0002162"} ! zygote stage relationship: RO:0002497 UBERON:0000071 ! death stage -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000062 name: organ +def: "Anatomical structure that performs a specific function or group of functions [WP]." [Wikipedia:Organ_(anatomy)] +xref: BIRNLEX:4 +xref: CARO:0020004 +xref: EFO:0000634 +xref: EMAPA:35949 +xref: ENVO:01000162 +xref: FMA:67498 +xref: MA:0003001 +xref: NCIT:C13018 +xref: SCTID:272625005 +xref: WBbt:0003760 +xref: Wikipedia:Organ_(anatomy) is_a: UBERON:0010000 ! multicellular anatomical structure disjoint_from: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0000467 ! part of anatomical system relationship: RO:0002002 UBERON:0006984 ! anatomical surface relationship: RO:0002215 GO:0008150 ! capable of biological_process relationship: RO:0002496 UBERON:0000111 {gci_filler="NCBITaxon:6072", gci_relation="RO:0002162"} ! organogenesis stage -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000063 name: organ subunit +def: "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:86140 is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0000064 name: organ part +def: "A multicellular structure that is a part of an organ." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0011124 +xref: BIRNLEX:16 +xref: EFO:0000635 +xref: FMA:82472 +xref: SCTID:113343008 +xref: SCTID:91717005 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000062 ! part of organ -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000065 name: respiratory tract +def: "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts." [https://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0001606 +xref: EHDAA:1568 +xref: EHDAA:2219 +xref: EMAPA:16737 +xref: FMA:265130 +xref: SCTID:361110005 +xref: VHOG:0000393 is_a: UBERON:0001005 ! respiratory airway is_a: UBERON:0004119 ! endoderm-derived structure relationship: RO:0002202 UBERON:0007026 ! presumptive gut relationship: RO:0002202 UBERON:0008947 ! respiratory primordium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000066 name: fully formed stage +def: "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage." [https://orcid.org/0000-0002-6601-2165] +xref: BilaDO:0000004 +xref: BTO:0001043 +xref: EFO:0001272 +xref: FBdv:00005369 +xref: WBls:0000041 +xref: XtroDO:0000084 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000092 ! part of post-embryonic stage @@ -32148,6 +42203,20 @@ relationship: BFO:0000063 UBERON:0000071 ! precedes death stage [Term] id: UBERON:0000068 name: embryo stage +def: "A life cycle stage that starts with fertilization and ends with the fully formed embryo." [http://orcid.org/0000-0002-6601-2165] +xref: BilaDO:0000002 +xref: EV:0300001 +xref: FBdv:00005289 +xref: FMA:72652 +xref: HsapDv:0000002 +xref: MmusDv:0000002 +xref: OGES:000000 +xref: OGES:000022 +xref: SCTID:296280003 +xref: WBls:0000003 +xref: WBls:0000092 +xref: WBls:0000102 +xref: XAO:1000012 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage disjoint_from: UBERON:0000092 ! post-embryonic stage @@ -32158,16 +42227,19 @@ relationship: RO:0002082 GO:0009790 ! embryo development [Term] id: UBERON:0000071 name: death stage +def: "End of the life of an organism." [XAO:0000437] +xref: XAO:0000437 +xref: XtroDO:0000085 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: RO:0002229 UBERON:0000104 ! life cycle -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000072 name: proximo-distal subdivision of respiratory tract +def: "An section of a respiratory tract." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:45660 +xref: MA:0000434 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube @@ -32177,6 +42249,10 @@ relationship: BFO:0000050 UBERON:0000065 ! part of respiratory tract [Term] id: UBERON:0000073 name: regional part of nervous system +def: "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS." [BIRNLEX:1157] +xref: BIRNLEX:1157 +xref: NCIT:C13040 +xref: SCTID:25087005 is_a: UBERON:0000481 ! multi-tissue structure intersection_of: UBERON:0000481 ! multi-tissue structure intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system @@ -32185,6 +42261,11 @@ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system [Term] id: UBERON:0000075 name: subdivision of skeletal system +def: "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: FMA:85544 +xref: galen:ComplexSkeletalStructure +xref: NCIT:C34076 +xref: SCTID:118966000 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0001434 ! part of skeletal system relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -32193,6 +42274,18 @@ relationship: RO:0002473 UBERON:0004765 ! skeletal element [Term] id: UBERON:0000076 name: external ectoderm +def: "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm." [MGI:anna, MP:0012532] +xref: EHDAA2:0001968 +xref: EHDAA:1494 +xref: EHDAA:350 +xref: EHDAA:4784 +xref: EHDAA:4790 +xref: EHDAA:4796 +xref: EHDAA:7860 +xref: EMAPA:16096 +xref: FMA:87656 +xref: NCIT:C34309 +xref: Wikipedia:External_ectoderm is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm @@ -32200,6 +42293,7 @@ relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm [Term] id: UBERON:0000077 name: mixed endoderm/mesoderm-derived structure +def: "An anatomical structure that develops from the endoderm and the mesoderm." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000061 ! anatomical structure @@ -32209,6 +42303,7 @@ intersection_of: RO:0002202 UBERON:0000926 ! mesoderm [Term] id: UBERON:0000078 name: mixed ectoderm/mesoderm/endoderm-derived structure +def: "An anatomical structure that develops from the ectoderm, mesoderm and endoderm." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000061 ! anatomical structure @@ -32219,6 +42314,15 @@ intersection_of: RO:0002202 UBERON:0000926 ! mesoderm [Term] id: UBERON:0000085 name: morula +def: "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [MP:0012130] +xref: BTO:0001508 +xref: EHDAA2:0000005 +xref: FMA:292334 +xref: GAID:1295 +xref: MESH:D009028 +xref: NCIT:C34212 +xref: SCTID:361474003 +xref: Wikipedia:Morula is_a: UBERON:0000922 ! embryo relationship: BFO:0000050 UBERON:0004716 ! part of conceptus relationship: BFO:0000051 CL:0000353 ! has part blastoderm cell @@ -32229,15 +42333,38 @@ relationship: RO:0002492 UBERON:0000107 ! cleavage stage [Term] id: UBERON:0000086 name: zona pellucida +def: "A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes." [Wikipedia:Zona_pellucida] +xref: BTO:0003135 +xref: EHDAA2:0002220 +xref: EHDAA:31 +xref: EHDAA:62 +xref: EMAPA:16035 +xref: FMA:18674 +xref: GAID:410 +xref: MA:0001715 +xref: MESH:D015044 +xref: NCIT:C33896 +xref: TAO:0001111 +xref: Wikipedia:Zona_pellucida +xref: ZFA:0001111 is_a: UBERON:0005764 ! acellular membrane relationship: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000051 CHEBI:17089 ! has part relationship: RO:0002007 CL:0000023 ! bounding layer of oocyte -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000087 name: inner cell mass +def: "A mass of cells that develop into the body of the embryo and some extraembryonic tissues." [ISBN:0-683-40008-8, MGI:pvb] +xref: EFO:0000547 +xref: EHDAA2:0000830 +xref: EHDAA:40 +xref: EMAPA:16041 +xref: FMA:86557 +xref: NCIT:C13740 +xref: SCTID:361456007 +xref: VHOG:0000742 +xref: Wikipedia:Inner_cell_mass is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0000358 ! blastocyst relationship: RO:0002219 UBERON:0000088 ! trophoblast @@ -32245,6 +42372,17 @@ relationship: RO:0002219 UBERON:0000088 ! trophoblast [Term] id: UBERON:0000088 name: trophoblast +def: "The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta." [ISBN:0-683-40008-8, MP:0005031] +comment: Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast] +xref: BTO:0001079 +xref: CALOHA:TS-1070 +xref: EV:0100120 +xref: FMA:83029 +xref: GAID:1152 +xref: MESH:D014327 +xref: NCIT:C93292 +xref: SCTID:362839005 +xref: Wikipedia:Trophoblast is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000358 ! part of blastocyst relationship: RO:0002202 UBERON:0004345 ! trophectoderm @@ -32253,12 +42391,24 @@ relationship: RO:0002473 CL:0000351 ! trophoblast cell [Term] id: UBERON:0000091 name: bilaminar disc +def: "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc." [MP:0003886] +xref: FMA:293863 +xref: NCIT:C34112 +xref: Wikipedia:Bilaminar_disc is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0000087 ! inner cell mass [Term] id: UBERON:0000092 name: post-embryonic stage +def: "Stage succeeding embryo, including mature structure." [https://orcid.org/0000-0002-6601-2165] +xref: BilaDO:0000003 +xref: OGES:000010 +xref: OGES:000014 +xref: OGES:000024 +xref: WBls:0000022 +xref: WBls:0000093 +xref: WBls:0000103 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000062 UBERON:0000068 ! preceded by embryo stage @@ -32267,12 +42417,19 @@ relationship: RO:0002082 GO:0009791 ! post-embryonic development [Term] id: UBERON:0000094 name: membrane organ +def: "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]." [FMA:7145] +xref: FMA:7145 is_a: UBERON:0000062 ! organ relationship: RO:0002473 UBERON:0011823 ! dense connective tissue [Term] id: UBERON:0000095 name: cardiac neural crest +def: "Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]." [Wikipedia:Cardiac_neural_crest] +xref: TAO:0002173 +xref: Wikipedia:Cardiac_neural_crest +xref: XAO:0004190 +xref: ZFA:0001648 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0002342 ! part of neural crest @@ -32281,6 +42438,13 @@ relationship: RO:0002131 UBERON:0005428 ! overlaps vagal neural crest [Term] id: UBERON:0000101 name: lobe of lung +def: "A lung lobe is one of the rounded projections that compose the lung[GO]." [GOC:GO] +xref: EMAPA:36281 +xref: FMA:7311 +xref: galen:LobeOfLung +xref: MA:0003098 +xref: NCIT:C34021 +xref: SCTID:245524004 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0009912 ! anatomical lobe relationship: BFO:0000050 UBERON:0002048 ! part of lung @@ -32289,6 +42453,8 @@ relationship: RO:0002433 UBERON:0002048 ! lung [Term] id: UBERON:0000102 name: lung vasculature +def: "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]." [GOC:GO] +xref: FMA:73750 is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature @@ -32298,27 +42464,54 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: UBERON:0000104 name: life cycle +def: "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism." [https://orcid.org/0000-0002-6601-2165] +xref: FBdv:00000000 +xref: HsapDv:0000001 +xref: MmusDv:0000001 +xref: ncithesaurus:Life +xref: OGES:000011 is_a: BFO:0000003 is_a: UBERON:0000000 ! processual entity relationship: BFO:0000051 UBERON:0000105 ! has part life cycle stage relationship: RO:0002224 UBERON:0000106 {gci_filler="NCBITaxon:33208", gci_relation="RO:0002162"} ! starts with zygote stage relationship: RO:0002230 UBERON:0000071 ! ends with death stage -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000105 name: life cycle stage +def: "A spatiotemporal region encompassing some part of the life cycle of an organism." [https://orcid.org/0000-0002-6601-2165] +xref: BILS:0000105 +xref: EFO:0000399 +xref: FBdv:00007012 +xref: FMA:24120 +xref: HsapDv:0000000 +xref: MESH:D008018 +xref: MmusDv:0000000 +xref: ncithesaurus:Developmental_Stage +xref: OlatDv:0000010 +xref: PdumDv:0000090 +xref: WBls:0000002 +xref: XAO:1000000 +xref: ZFS:0000000 +xref: ZFS:0100000 is_a: UBERON:0000000 ! processual entity relationship: BFO:0000050 UBERON:0000104 ! part of life cycle -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000106 name: zygote stage +def: "A stage at which the organism is a single cell produced by means of sexual reproduction." [Wikipedia:Zygote] +xref: BilaDO:0000005 +xref: BILS:0000106 +xref: EFO:0001322 +xref: EHDAA:27 +xref: FBdv:00005288 +xref: NCIT:C12601 +xref: PdumDv:0000100 +xref: VHOG:0000745 +xref: Wikipedia:Zygote +xref: XAO:1000001 +xref: ZFS:0000001 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage @@ -32327,6 +42520,19 @@ relationship: RO:0002223 UBERON:0000104 ! life cycle [Term] id: UBERON:0000107 name: cleavage stage +def: "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula." [GO:0040016, Wikipedia:Cleavage_(embryo)] +xref: BilaDO:0000006 +xref: BILS:0000107 +xref: EFO:0001290 +xref: FBdv:00000054 +xref: MESH:D002970 +xref: MmusDv:0000004 +xref: OGES:000015 +xref: OGES:000020 +xref: PdumDv:0000200 +xref: Wikipedia:Cleavage_(embryo) +xref: XAO:1000004 +xref: ZFS:0000046 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage intersection_of: UBERON:0000105 ! life cycle stage @@ -32338,6 +42544,19 @@ relationship: RO:0002087 UBERON:0000106 ! immediately preceded by zygote stage [Term] id: UBERON:0000108 name: blastula stage +def: "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [Wikipedia:Blastula] +xref: BilaDO:0000007 +xref: BILS:0000108 +xref: EFO:0001282 +xref: HsapDv:0000006 +xref: MmusDv:0000007 +xref: OGES:000003 +xref: OGES:000016 +xref: OGES:000021 +xref: WBls:0000005 +xref: Wikipedia:Blastula +xref: XAO:1000003 +xref: ZFS:0000045 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage @@ -32346,6 +42565,18 @@ relationship: BFO:0000062 UBERON:0000107 ! preceded by cleavage stage [Term] id: UBERON:0000109 name: gastrula stage +def: "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GO:0007369] +xref: BilaDO:0000008 +xref: BILS:0000109 +xref: EFO:0001296 +xref: FBdv:00005317 +xref: HsapDv:0000010 +xref: MmusDv:0000013 +xref: OGES:000004 +xref: OGES:000019 +xref: WBls:0000010 +xref: XAO:1000005 +xref: ZFS:0000047 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage @@ -32356,6 +42587,12 @@ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0000110 name: neurula stage +def: "Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GO:0001841] +xref: BilaDO:0000009 +xref: BILS:0000110 +xref: HsapDv:0000012 +xref: MmusDv:0000017 +xref: XAO:1000006 is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage @@ -32366,6 +42603,14 @@ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0000111 name: organogenesis stage +def: "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism." [Wikipedia:Organogenesis] +xref: BilaDO:0000010 +xref: BILS:0000111 +xref: HsapDv:0000015 +xref: MmusDv:0000018 +xref: OGES:000005 +xref: OGES:000032 +xref: Wikipedia:Organogenesis is_a: BFO:0000003 is_a: UBERON:0000105 ! life cycle stage relationship: BFO:0000050 UBERON:0000068 ! part of embryo stage @@ -32376,6 +42621,11 @@ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0000114 name: lung connective tissue +def: "The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin." [ISBN:0-683-40008-8, MGI:anna, MP:0002276, PMID:14635660] +xref: EMAPA:35521 +xref: FMA:27533 +xref: MA:0001782 +xref: SCTID:201609008 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003580 ! lower respiratory tract connective tissue is_a: UBERON:0003837 ! thoracic segment connective tissue @@ -32384,11 +42634,14 @@ intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002433 UBERON:0002048 ! lung relationship: RO:0002494 UBERON:0004883 ! lung mesenchyme -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000115 name: lung epithelium +def: "The epithelial layer of the lung." [MP:0006382] +xref: BTO:0001653 +xref: EMAPA:32860 +xref: MA:0001783 is_a: UBERON:0004815 ! lower respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -32399,6 +42652,8 @@ relationship: RO:0002433 UBERON:0002048 ! lung [Term] id: UBERON:0000117 name: respiratory tube +def: "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea." [GO:0030323, http://orcid.org/0000-0002-6601-2165] +xref: FMA:12224 is_a: UBERON:0000025 ! tube is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000025 ! tube @@ -32409,6 +42664,13 @@ relationship: BFO:0000051 UBERON:0000483 ! has part epithelium [Term] id: UBERON:0000118 name: lung bud +def: "Structure derived from foregut that becomes a lung[GO]." [GO:0060431, Wikipedia:Respiratory_bud] +xref: BTO:0001643 +xref: EHDAA2:0004089 +xref: NCIT:C34260 +xref: NCIT:C34282 +xref: SCTID:361427007 +xref: Wikipedia:Respiratory_bud is_a: UBERON:0005153 ! epithelial bud is_a: UBERON:0005911 ! endo-epithelium relationship: RO:0002202 UBERON:0005597 ! lung primordium @@ -32418,6 +42680,9 @@ relationship: RO:0002220 UBERON:0004872 ! adjacent to splanchnic layer of latera [Term] id: UBERON:0000122 name: neuron projection bundle +def: "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." [CARO:0001001, FBbt:00005099, FBC:DOS] +xref: CARO:0001001 +xref: NLX:147821 is_a: UBERON:0005162 ! multi cell part structure relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: BFO:0000051 GO:0043005 ! has part neuron projection @@ -32425,6 +42690,12 @@ relationship: BFO:0000051 GO:0043005 ! has part neuron projection [Term] id: UBERON:0000125 name: neural nucleus +def: "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO)." [NLX:28443] +xref: AEO:0000136 +xref: FMA:83686 +xref: NCIT:C13197 +xref: NLX:28443 +xref: Wikipedia:Nucleus_(neuroanatomy) is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: RO:0002160 NCBITaxon:7711 ! Chordata relationship: RO:0002473 UBERON:0002020 ! gray matter @@ -32432,6 +42703,11 @@ relationship: RO:0002473 UBERON:0002020 ! gray matter [Term] id: UBERON:0000126 name: cranial nerve nucleus +def: "Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves." [NLX:28532] +xref: FMA:54501 +xref: NLX:28532 +xref: SCTID:280160003 +xref: Wikipedia:Cranial_nerve_nucleus is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: extends_fibers_into UBERON:0001785 ! cranial nerve @@ -32453,17 +42729,139 @@ relationship: RO:0002160 NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0000158 name: membranous layer +xref: FMA:30322 +xref: FMA:82500 +xref: MESH:D008566 +xref: NCIT:C12749 is_a: UBERON:0004923 ! organ component layer relationship: RO:0002007 UBERON:0000064 ! bounding layer of organ part +[Term] +id: UBERON:0000159 +name: anal canal +def: "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus." [Wikipedia:Anal_canal] +xref: BTO:0001978 +xref: CALOHA:TS-2160 +xref: EMAPA:18256 +xref: FMA:15703 +xref: galen:AnalCanal +xref: MA:0000330 +xref: NCIT:C12375 +xref: SCTID:245438008 +xref: Wikipedia:Anal_canal +is_a: UBERON:0004111 ! anatomical conduit +is_a: UBERON:0004121 ! ectoderm-derived structure +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001353 ! part of anal region +relationship: channel_for UBERON:0001988 ! feces +relationship: RO:0002150 UBERON:0001052 ! rectum +relationship: RO:0002150 UBERON:0001245 ! anus +relationship: RO:0002202 UBERON:0011272 ! embryonic skin basal layer + +[Term] +id: UBERON:0000160 +name: intestine +def: "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine." [GOC:GO, Wikipedia:Intestine] +xref: AAO:0000246 +xref: ANISEED:1235303 +xref: BSA:0000093 +xref: BTO:0000648 +xref: CALOHA:TS-0490 +xref: EFO:0000834 +xref: EMAPA:32874 +xref: EV:0100071 +xref: FMA:7199 +xref: GAID:295 +xref: galen:Intestine +xref: MA:0000328 +xref: MA:0001524 +xref: MESH:D007422 +xref: MIAA:0000043 +xref: NCIT:C12736 +xref: SCTID:256876008 +xref: TAO:0001338 +xref: VHOG:0000056 +xref: WBbt:0005772 +xref: Wikipedia:Intestine +xref: XAO:0000129 +xref: ZFA:0001338 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system +relationship: RO:0002433 UBERON:0001007 ! digestive system + [Term] id: UBERON:0000161 name: orifice +def: "Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]." [FMA:3724] +xref: FMA:3724 +xref: SCTID:91837002 is_a: UBERON:0004111 ! anatomical conduit +[Term] +id: UBERON:0000162 +name: cloaca +def: "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures." [ISBN:0073040584, Wikipedia:Cloaca] +xref: AAO:0000095 +xref: GAID:1206 +xref: MESH:D002988 +xref: NCIT:C34127 +xref: SCTID:362857006 +xref: SCTID:370631000 +xref: VHOG:0001186 +xref: Wikipedia:Cloaca +xref: XAO:0000244 +xref: ZFA:0005781 +is_a: UBERON:0013522 ! subdivision of tube +relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract +relationship: BFO:0000050 UBERON:0004122 ! part of genitourinary system +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata + +[Term] +id: UBERON:0000163 +name: embryonic cloaca +def: "Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]." [MP:0010115, Wikipedia:Cloaca_(embryology)] +xref: EHDAA2:0000256 +xref: EHDAA:4895 +xref: EMAPA:27573 +xref: Wikipedia:Cloaca_(embryology) +is_a: UBERON:0000162 ! cloaca +relationship: BFO:0000050 UBERON:0000922 ! part of embryo +relationship: BFO:0000050 UBERON:0001008 ! part of renal system +relationship: BFO:0000050 UBERON:0012361 ! part of internal anal region +relationship: RO:0002254 UBERON:0003064 ! intermediate mesoderm + [Term] id: UBERON:0000165 name: mouth +def: "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract, Wikipedia:Mouth] +xref: AAO:0010355 +xref: BTO:0001090 +xref: BTO:0004698 +xref: CALOHA:TS-1315 +xref: EFO:0000825 +xref: EHDAA2:0001326 +xref: EHDAA:542 +xref: EMAPA:16262 +xref: FMA:49184 +xref: GAID:75 +xref: galen:Mouth +xref: http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg +xref: MA:0000341 +xref: MA:0002474 +xref: MAT:0000038 +xref: MESH:D009055 +xref: MIAA:0000038 +xref: SCTID:21082005 +xref: TADS:0000040 +xref: TAO:0000547 +xref: TAO:0000590 +xref: TGMA:0000131 +xref: VHOG:0000280 +xref: VHOG:0000812 +xref: Wikipedia:Mouth +xref: XAO:0003029 +xref: ZFA:0000547 +xref: ZFA:0000590 is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: BSPO:0001106 UBERON:0001555 ! digestive tract @@ -32474,6 +42872,8 @@ relationship: RO:0002202 UBERON:0035804 ! future mouth [Term] id: UBERON:0000166 name: oral opening +def: "The orifice that connects the mouth to the exterior of the body." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract] +xref: FMA:59806 is_a: UBERON:0000161 ! orifice relationship: BFO:0000050 UBERON:0000165 ! part of mouth relationship: RO:0002131 UBERON:0001004 {gci_filler="NCBITaxon:32523", gci_relation="BFO:0000050"} ! overlaps respiratory system @@ -32481,6 +42881,27 @@ relationship: RO:0002131 UBERON:0001004 {gci_filler="NCBITaxon:32523", gci_relat [Term] id: UBERON:0000167 name: oral cavity +def: "Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present)." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract, https://orcid.org/0000-0002-6601-2165, ISBN:0073040584] +xref: AAO:0000053 +xref: AAO:0000960 +xref: BSA:0000107 +xref: CALOHA:TS-1315 +xref: EFO:0001975 +xref: EHDAA2:0001324 +xref: EHDAA:6970 +xref: EMAPA:17411 +xref: EMAPA:18399 +xref: EV:0100057 +xref: FMA:20292 +xref: HAO:0000669 +xref: NCIT:C12421 +xref: SCTID:181220002 +xref: TAO:0001027 +xref: TGMA:0000102 +xref: VHOG:0000188 +xref: WBbt:0005255 +xref: XAO:0000126 +xref: ZFA:0001027 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000165 ! mouth @@ -32488,9 +42909,22 @@ relationship: BFO:0000050 UBERON:0000165 ! part of mouth relationship: RO:0002433 UBERON:0000165 ! mouth relationship: RO:0002572 UBERON:0000165 ! mouth +[Term] +id: UBERON:0000168 +name: proximal-distal subdivision of colon +def: "A section dividing a colon along a proximal-distal axis." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:222905 +is_a: UBERON:0004921 ! subdivision of digestive tract +intersection_of: UBERON:0013522 ! subdivision of tube +intersection_of: subdivision_of UBERON:0001155 ! colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon +relationship: subdivision_of UBERON:0001155 ! colon + [Term] id: UBERON:0000170 name: pair of lungs +def: "The pair of anatomical structures comprised of a left lung and right lung." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:68877 is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: RO:0002351 UBERON:0002167 ! right lung @@ -32501,40 +42935,128 @@ relationship: RO:0002351 UBERON:0002167 ! right lung relationship: RO:0002351 UBERON:0002167 {cardinality="1"} ! right lung relationship: RO:0002351 UBERON:0002168 ! left lung relationship: RO:0002351 UBERON:0002168 {cardinality="1"} ! left lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000171 name: respiration organ +def: "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [GO:0007585] +xref: SCTID:272626006 +xref: SPD:0000428 +xref: TGMA:0001247 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system +[Term] +id: UBERON:0000174 +name: excreta +def: "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity." [GO:0007588, http://orcid.org/0000-0002-6601-2165] +xref: AEO:0000184 +xref: BTO:0000491 +xref: EHDAA2_RETIRED:0003184 +xref: ENVO:02000022 +xref: FMA:9674 +xref: galen:Excretion +is_a: UBERON:0000463 ! organism substance +intersection_of: UBERON:0000463 ! organism substance +intersection_of: RO:0002353 GO:0007588 ! output of excretion +relationship: RO:0002353 GO:0007588 ! output of excretion + [Term] id: UBERON:0000178 name: blood +def: "A fluid that is composed of blood plasma and erythrocytes." [FMA:9670, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/9, Wikipedia:Blood] +xref: AAO:0000046 +xref: BTO:0000089 +xref: CALOHA:TS-0079 +xref: EFO:0000296 +xref: EHDAA2:0000176 +xref: EHDAA:418 +xref: EMAPA:16332 +xref: ENVO:02000027 +xref: EV:0100047 +xref: FMA:9670 +xref: GAID:965 +xref: galen:Blood +xref: MA:0000059 +xref: MESH:D001769 +xref: MIAA:0000315 +xref: NCIT:C12434 +xref: TAO:0000007 +xref: VHOG:0000224 +xref: Wikipedia:Blood +xref: XAO:0000124 +xref: ZFA:0000007 is_a: UBERON:0000179 ! haemolymphatic fluid relationship: BFO:0000050 UBERON:0002390 ! part of hematopoietic system relationship: BFO:0000051 CL:0000232 ! has part erythrocyte relationship: BFO:0000051 UBERON:0001969 ! has part blood plasma relationship: RO:0001025 UBERON:0002049 ! vasculature relationship: RO:0002495 UBERON:0006596 ! presumptive blood -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000179 name: haemolymphatic fluid +def: "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs." [http://orcid.org/0000-0002-6601-2165] +xref: CARO:0000081 is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system relationship: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa +[Term] +id: UBERON:0000209 +name: tetrapod frontal bone +def: "The bone forming the forehead and roof of the eye orbit." [ISBN:0-683-40008-8, MP:0000107, PMID:7914451, Wikipedia:Frontal_bone] +xref: AAO:0000206 +xref: EMAPA:19016 +xref: FMA:52734 +xref: GAID:226 +xref: MA:0001466 +xref: MESH:D005624 +xref: NCIT:C32635 +xref: SCTID:181793006 +xref: VSAO:0000208 +xref: Wikipedia:Frontal_bone +is_a: UBERON:0002514 ! intramembranous bone +is_a: UBERON:0008907 ! dermal bone +is_a: UBERON:0010428 ! flat bone +is_a: UBERON:0011164 ! neurocranium bone +relationship: BFO:0000050 UBERON:0003113 ! part of dermatocranium +relationship: RO:0002131 UBERON:0001697 ! overlaps orbit of skull + +[Term] +id: UBERON:0000220 +name: atlanto-occipital joint +def: "The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital." [Wikipedia:Atlanto-occipital_joint] +xref: FMA:24939 +xref: NCIT:C32158 +xref: ncithesaurus:Atlanto-occipital_Joint-Atlanto +xref: SCTID:361831006 +xref: Wikipedia:Atlanto-occipital_joint +is_a: UBERON:0002217 ! synovial joint +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0002217 ! synovial joint +intersection_of: RO:0002176 UBERON:0001092 ! vertebral bone 1 +intersection_of: RO:0002176 UBERON:0001676 ! occipital bone +relationship: BFO:0000050 UBERON:0011138 ! part of postcranial axial skeletal system +relationship: BSPO:0000126 UBERON:0006072 ! cervical region of vertebral column +relationship: RO:0002176 UBERON:0001092 ! vertebral bone 1 +relationship: RO:0002176 UBERON:0001676 ! occipital bone + [Term] id: UBERON:0000304 name: tendon sheath +def: "A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath." [Wikipedia:Tendon_sheath] +xref: BTO:0000051 +xref: FMA:45087 +xref: FMA:76715 +xref: NCIT:C96299 +xref: SCTID:361885006 +xref: Wikipedia:Tendon_sheath is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002007 UBERON:0000043 ! bounding layer of tendon @@ -32545,22 +43067,82 @@ relationship: RO:0002007 UBERON:0000043 ! bounding layer of tendon [Term] id: UBERON:0000307 name: blastula +def: "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [Wikipedia:Blastula] +xref: BILA:0000059 +xref: BTO:0000128 +xref: GAID:1294 +xref: MESH:D036703 +xref: OGEM:000006 +xref: Wikipedia:Blastula is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002491 UBERON:0000108 ! blastula stage relationship: RO:0002202 UBERON:0007010 ! cleaving embryo relationship: RO:0002491 UBERON:0000108 ! blastula stage +[Term] +id: UBERON:0000317 +name: colonic mucosa +def: "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000271 +xref: CALOHA:TS-0164 +xref: EFO:0003038 +xref: EMAPA:27375 +xref: FMA:14984 +xref: FMA:85388 +xref: MA:0003194 +xref: SCTID:362157008 +is_a: UBERON:0001207 ! mucosa of large intestine +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0000320 +name: duodenal mucosa +def: "A mucosa that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000367 +xref: CALOHA:TS-0213 +xref: EMAPA:27235 +xref: FMA:14942 +xref: MA:0003207 +xref: SCTID:362146003 +is_a: UBERON:0001204 ! mucosa of small intestine +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + [Term] id: UBERON:0000325 name: gastric gland +def: "The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin." [MGI:anna] +xref: BTO:0000503 +xref: EMAPA:27181 +xref: FMA:14919 is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003294 ! gland of foregut relationship: BFO:0000050 UBERON:0006924 ! part of stomach glandular epithelium +[Term] +id: UBERON:0000326 +name: pancreatic juice +def: "Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GO:0030157] +xref: BTO:0000504 +xref: CALOHA:TS-2235 +xref: FMA:62973 +xref: GAID:1166 +xref: MESH:D010189 +is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: RO:0003001 UBERON:0001264 ! produced by pancreas +relationship: RO:0003001 UBERON:0001264 ! produced by pancreas + [Term] id: UBERON:0000328 name: gut wall +def: "The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity)." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000547 +xref: FMA:45653 is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract @@ -32569,15 +43151,46 @@ relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: UBERON:0000332 name: yellow bone marrow +def: "Bone marrow in which the fat cells predominate in the meshes of the reticular network." [http://medical-dictionary.thefreedictionary.com/Yellow+Marrow] +xref: BTO:0000635 +xref: FMA:74596 +xref: SCTID:328639002 +xref: SCTID:5023006 is_a: UBERON:0002371 ! bone marrow intersection_of: UBERON:0002371 ! bone marrow intersection_of: RO:0002473 CL:0000136 ! adipocyte relationship: BFO:0000050 UBERON:0007195 ! part of stroma of bone marrow relationship: RO:0002473 CL:0000136 ! adipocyte +[Term] +id: UBERON:0000333 +name: intestinal gland +def: "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0000640 +xref: FMA:15052 +xref: SCTID:266297002 +is_a: UBERON:0003408 ! gland of digestive tract +intersection_of: UBERON:0002530 ! gland +intersection_of: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa +relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa + [Term] id: UBERON:0000344 name: mucosa +def: "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]." [Wikipedia:Mucous_membrane] +xref: AEO:0000199 +xref: BTO:0000886 +xref: CALOHA:TS-2031 +xref: EHDAA2_RETIRED:0003234 +xref: EV:0100382 +xref: FMA:85355 +xref: FMA:85358 +xref: GAID:297 +xref: galen:Mucosa +xref: MESH:D009092 +xref: NCIT:C13166 +xref: SCTID:361693009 +xref: Wikipedia:Mucous_membrane is_a: UBERON:0004923 ! organ component layer relationship: BFO:0000051 UBERON:0000483 ! has part epithelium relationship: BFO:0000051 UBERON:0002384 ! has part connective tissue @@ -32586,6 +43199,22 @@ relationship: RO:0002160 NCBITaxon:7711 ! Chordata [Term] id: UBERON:0000353 name: parenchyma +def: "Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues." [Wikipedia:Parenchyma] +xref: EHDAA:3015 +xref: EHDAA:3905 +xref: EHDAA:3999 +xref: EHDAA:4005 +xref: EHDAA:6899 +xref: EHDAA:6903 +xref: EHDAA:6994 +xref: EHDAA:8086 +xref: EHDAA:9182 +xref: EHDAA:9190 +xref: EHDAA:9196 +xref: EHDAA:9202 +xref: FMA:45732 +xref: NCIT:C74601 +xref: Wikipedia:Parenchyma is_a: UBERON:0000064 ! organ part disjoint_from: UBERON:0003891 ! stroma relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa @@ -32594,6 +43223,12 @@ relationship: RO:0002215 GO:0032501 ! capable of multicellular organismal proces [Term] id: UBERON:0000355 name: pharyngeal mucosa +def: "A mucosa that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001047 +xref: EMAPA:26957 +xref: FMA:55031 +xref: MA:0003143 +xref: SCTID:362121003 is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx @@ -32602,6 +43237,18 @@ relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx [Term] id: UBERON:0000358 name: blastocyst +def: "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]." [GO:0001824, Wikipedia:Blastocyst] +xref: BTO:0001099 +xref: CALOHA:TS-0076 +xref: EFO:0000295 +xref: EMAPA:36035 +xref: EV:0100394 +xref: FMA:83041 +xref: GAID:1153 +xref: MESH:D001755 +xref: NCIT:C13739 +xref: SCTID:308837009 +xref: Wikipedia:Blastocyst is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000307 ! part of blastula relationship: BFO:0000051 UBERON:0000087 ! has part inner cell mass @@ -32613,6 +43260,11 @@ relationship: RO:0002491 UBERON:0000108 ! blastula stage [Term] id: UBERON:0000361 name: red bone marrow +def: "The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream." [http://medical-dictionary.thefreedictionary.com/red+marrow] +xref: BTO:0001160 +xref: FMA:74595 +xref: SCTID:328538003 +xref: SCTID:75330005 is_a: UBERON:0002371 ! bone marrow intersection_of: UBERON:0002371 ! bone marrow intersection_of: RO:0002473 CL:0000988 ! hematopoietic cell @@ -32622,6 +43274,15 @@ relationship: RO:0002473 CL:0000988 ! hematopoietic cell [Term] id: UBERON:0000371 name: syncytiotrophoblast +def: "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated)." [http://embryology.med.unsw.edu.au/Notes/placenta5.htm, Wikipedia:Syncytiotrophoblast] +xref: BTO:0001335 +xref: EHDAA:129 +xref: EHDAA:91 +xref: EMAPA:16068 +xref: FMA:83040 +xref: NCIT:C33918 +xref: SCTID:256965005 +xref: Wikipedia:Syncytiotrophoblast is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004364 ! part of ectoplacental cone relationship: RO:0002473 CL:0000525 ! syncytiotrophoblast cell @@ -32629,13 +43290,28 @@ relationship: RO:0002473 CL:0000525 ! syncytiotrophoblast cell [Term] id: UBERON:0000377 name: maxillary nerve +def: "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses." [MP:0009799, Wikipedia:Maxillary_nerve] +xref: AAO:0010670 +xref: BTO:0001378 +xref: EHDAA2:0002087 +xref: EMAPA:17799 +xref: FMA:52724 +xref: GAID:836 +xref: MA:0001103 +xref: MESH:D008442 +xref: SCTID:280211001 +xref: VHOG:0001346 +xref: Wikipedia:Maxillary_nerve is_a: UBERON:0011779 ! nerve of head region relationship: RO:0002380 UBERON:0001645 ! trigeminal nerve -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000379 name: tracheal mucosa +def: "A mucosa that is part of a respiratory airway." [OBOL:automatic] +xref: BTO:0001390 +xref: FMA:7471 +xref: SCTID:660006 is_a: UBERON:0004785 ! respiratory system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001005 ! part of respiratory airway @@ -32644,17 +43320,34 @@ relationship: BFO:0000050 UBERON:0001005 ! part of respiratory airway [Term] id: UBERON:0000383 name: musculature of body +def: "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]." [VSAO:0000033] +xref: AAO:0000307 +xref: BILA:0000088 +xref: BTO:0001369 +xref: BTO:0001485 +xref: EFO:0000801 +xref: FMA:72954 +xref: MA:0002888 +xref: MAT:0000025 +xref: MIAA:0000025 +xref: VSAO:0000033 +xref: XAO:0004042 is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: RO:0002473 UBERON:0001015 ! musculature relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa relationship: RO:0002215 GO:0003012 ! capable of muscle system process relationship: RO:0002473 UBERON:0001015 ! musculature -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000389 name: lens cortex +def: "Tissue that surrounds the lens nucleus." [http://www.thefreedictionary.com/lens+cortex] +xref: BTO:0001632 +xref: CALOHA:TS-0542 +xref: FMA:58970 +xref: MESH:D007904 +xref: SCTID:280626006 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000479 ! tissue @@ -32662,11 +43355,15 @@ intersection_of: RO:0002221 UBERON:0000390 ! lens nucleus relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: RO:0002202 UBERON:0005614 ! lens anterior epithelium relationship: RO:0002221 UBERON:0000390 ! lens nucleus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000390 name: lens nucleus +def: "The core of the crystalline lens, surrounded by the cortex." [BTO:0001633] +xref: BTO:0001633 +xref: FMA:58971 +xref: MESH:D007907 +xref: SCTID:280628007 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0034944 ! zone of organ intersection_of: UBERON:0034944 ! zone of organ @@ -32674,11 +43371,31 @@ intersection_of: RO:0002219 UBERON:0000389 ! lens cortex relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: RO:0002202 UBERON:0005614 ! lens anterior epithelium relationship: RO:0002219 UBERON:0000389 ! lens cortex -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0000397 +name: colonic epithelium +def: "An epithelium that is part of a colon [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001709 +xref: CALOHA:TS-0163 +xref: EMAPA:18941 +xref: FMA:17302 +xref: MA:0003195 +xref: SCTID:42978003 +xref: TAO:0005128 +xref: ZFA:0005128 +is_a: UBERON:0001278 ! epithelium of large intestine +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon [Term] id: UBERON:0000409 name: serous gland +def: "A gland in which the principal secretory cells are serous secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] +xref: BTO:0001837 +xref: FMA:62889 +xref: Wikipedia:Serous_gland is_a: UBERON:0002365 ! exocrine gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: BFO:0000051 CL:0000313 ! has part serous secreting cell @@ -32689,23 +43406,67 @@ relationship: RO:0003000 UBERON:0007794 ! produces secretion of serous gland [Term] id: UBERON:0000410 name: bronchial mucosa +def: "A mucosa that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001846 +xref: FMA:62652 +xref: SCTID:30802009 is_a: UBERON:0000379 ! tracheal mucosa is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus +[Term] +id: UBERON:0000414 +name: mucous gland +def: "A gland in which the principal secretory cells are mucus secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] +xref: AAO:0010601 +xref: BTO:0001979 +xref: FMA:62888 +xref: Wikipedia:Mucous_gland +is_a: UBERON:0002365 ! exocrine gland +intersection_of: UBERON:0002365 ! exocrine gland +intersection_of: BFO:0000051 CL:0000319 ! has part mucus secreting cell +relationship: BFO:0000051 CL:0000319 ! has part mucus secreting cell +relationship: RO:0002215 GO:0070254 ! capable of mucus secretion +relationship: RO:0003000 UBERON:0000912 ! produces mucus + [Term] id: UBERON:0000415 name: artery wall +def: "An anatomical wall that is part of an artery [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0002009 +xref: FMA:14155 +xref: galen:ArterialWall is_a: UBERON:0035965 ! wall of blood vessel intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001637 ! part of artery relationship: BFO:0000050 UBERON:0001637 ! part of artery +[Term] +id: UBERON:0000440 +name: trabecula +def: "A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]." [GO:0060343, Wikipedia:Trabecula] +xref: BTO:0002501 +xref: FMA:85273 +xref: Wikipedia:Trabecula +is_a: UBERON:0000064 ! organ part +relationship: BFO:0000051 UBERON:0002384 ! has part connective tissue +relationship: RO:0000086 PATO:0001873 + [Term] id: UBERON:0000456 name: secretion of exocrine gland +def: "A portion of organism substance that is produced by exocrine glands." [http://orcid.org/0000-0002-6601-2165] +xref: AEO:0001005 +xref: BTO:0002977 +xref: BTO:0002979 +xref: EMAPA:36535 +xref: FMA:9675 +xref: galen:Secretion +xref: MA:0002504 +xref: MESH:D012634 +xref: NCIT:C34062 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0002365 ! produced by exocrine gland @@ -32714,73 +43475,224 @@ relationship: RO:0003001 UBERON:0002365 ! produced by exocrine gland [Term] id: UBERON:0000463 name: organism substance +def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010839 +xref: AEO:0000004 +xref: BILA:0000004 +xref: CALOHA:TS-2101 +xref: CARO:0000004 +xref: EHDAA2:0003004 +xref: EMAPA:35178 +xref: FMA:9669 +xref: galen:BodySubstance +xref: HAO:0000004 +xref: MA:0002450 +xref: NCIT:C13236 +xref: SPD:0000008 +xref: TAO:0001487 +xref: TGMA:0001824 +xref: VHOG:0001726 +xref: XAO:0004001 +xref: ZFA:0001487 is_a: UBERON:0000465 ! material anatomical entity relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: RO:0000086 PATO:0002198 -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000464 name: anatomical space +def: "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010110 +xref: AEO:0000005 +xref: BILA:0000005 +xref: CARO:0000005 +xref: EHDAA2:0003005 +xref: FMA:5897 +xref: HAO:0000005 +xref: NCIT:C94478 +xref: TAO:0001668 +xref: TGMA:0001825 +xref: VHOG:0001728 +xref: XAO:0003190 +xref: ZFA:0001643 is_a: UBERON:0000466 ! immaterial anatomical entity relationship: RO:0002219 UBERON:0000061 ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000465 name: material anatomical entity +def: "Anatomical entity that has mass." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010264 +xref: AEO:0000006 +xref: BILA:0000006 +xref: CARO:0000006 +xref: EHDAA2:0003006 +xref: FMA:67165 +xref: HAO:0000006 +xref: TAO:0001836 +xref: TGMA:0001826 +xref: VHOG:0001721 is_a: BFO:0000040 is_a: UBERON:0001062 ! anatomical entity disjoint_from: UBERON:0000466 ! immaterial anatomical entity -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000466 name: immaterial anatomical entity +def: "Anatomical entity that has no mass." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010265 +xref: AEO:0000007 +xref: BILA:0000007 +xref: CARO:0000007 +xref: EHDAA2:0003007 +xref: FMA:67112 +xref: HAO:0000007 +xref: TAO:0001835 +xref: TGMA:0001827 +xref: VHOG:0001727 is_a: BFO:0000141 is_a: UBERON:0001062 ! anatomical entity -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000467 name: anatomical system +def: "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." [CARO:0000011] +xref: AAO:0000007 +xref: AEO:0000011 +xref: BILA:0000011 +xref: BIRNLEX:14 +xref: BSA:0000049 +xref: CALOHA:TS-2088 +xref: CARO:0000011 +xref: EHDAA2:0003011 +xref: EHDAA:392 +xref: EMAPA:16103 +xref: EV:0100000 +xref: FMA:7149 +xref: galen:AnatomicalSystem +xref: HAO:0000011 +xref: MA:0000003 +xref: NCIT:C12919 +xref: SCTID:278195005 +xref: TAO:0001439 +xref: TGMA:0001831 +xref: VHOG:0001725 +xref: WBbt:0005746 +xref: WBbt:0005763 +xref: Wikipedia:Organ_system +xref: XAO:0003002 +xref: ZFA:0001439 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: BFO:0000051 UBERON:0000062 ! has part organ relationship: RO:0002496 UBERON:0000111 {gci_filler="NCBITaxon:6072", gci_relation="RO:0002162"} ! organogenesis stage -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000468 name: multicellular organism +def: "Anatomical structure that is an individual member of a species and consists of more than one cell." [CARO:0000012, http://orcid.org/0000-0001-9114-8737, Wikipedia:Multi-cellular_organism] +xref: AAO:0010026 +xref: AEO:0000191 +xref: BILA:0000012 +xref: BIRNLEX:18 +xref: BSA:0000038 +xref: BTO:0000042 +xref: CARO:0000012 +xref: EFO:0002906 +xref: EHDAA2:0003103 +xref: EHDAA2:0003191 +xref: EHDAA:1 +xref: EMAPA:25765 +xref: EV:0100016 +xref: FMA:256135 +xref: galen:Organism +xref: HAO:0000012 +xref: NCIT:C13041 +xref: ncithesaurus:Whole_Organism +xref: SCTID:243928005 +xref: TADS:0000001 +xref: TAO:0001094 +xref: TGMA:0001832 +xref: VHOG:0000671 +xref: WBbt:0007833 +xref: Wikipedia:Multi-cellular_organism +xref: XAO:0003004 +xref: ZFA:0001094 is_a: UBERON:0010000 ! multicellular anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 + +[Term] +id: UBERON:0000471 +name: compound organ component +def: "Multi-tissue structure that is part of a compound organ." [CARO:0000019, http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010017 +xref: AEO:0000019 +xref: BILA:0000019 +xref: CARO:0000019 +xref: EHDAA2:0003019 +xref: HAO:0000019 +xref: TAO:0001489 +xref: TGMA:0001835 +xref: XAO:0003039 +xref: ZFA:0001489 +is_a: UBERON:0000481 ! multi-tissue structure +relationship: BFO:0000050 UBERON:0003103 ! part of compound organ [Term] id: UBERON:0000474 name: female reproductive system +def: "The organs and associated structures associated with bearing offspring in a female animal." [http://orcid.org/0000-0002-6601-2165, MP:0001119, Wikipedia:Female_genitalia] +xref: BTO:0000083 +xref: CALOHA:TS-1303 +xref: EFO:0000969 +xref: EHDAA2:0000506 +xref: EHDAA:8116 +xref: EMAPA:17959 +xref: EV:0100110 +xref: FMA:45663 +xref: GAID:364 +xref: HAO:0000324 +xref: MA:0000381 +xref: MESH:D005836 +xref: MIAA:0000028 +xref: NCIT:C12402 +xref: SCTID:361386004 +xref: TGMA:0000635 +xref: VHOG:0000726 +xref: Wikipedia:Female_genitalia +xref: WikipediaCategory:Female_reproductive_system +xref: XAO:0000156 is_a: UBERON:0000990 ! reproductive system intersection_of: UBERON:0000990 ! reproductive system intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism relationship: BFO:0000050 UBERON:0003100 ! part of female organism -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000475 name: organism subdivision +def: "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." [CARO:0000032, CARO:DOS, http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010053 +xref: AEO:0000032 +xref: BILA:0000032 +xref: BIRNLEX:7 +xref: CALOHA:TS-2084 +xref: CARO:0000032 +xref: EFO:0000808 +xref: EHDAA2:0003032 +xref: EMAPA:36031 +xref: FMA:7153 +xref: galen:BodyPart +xref: HAO:0000032 +xref: MA:0002433 +xref: MAT:0000293 +xref: MESH:D001829 +xref: MIAA:0000293 +xref: NCIT:C32221 +xref: TAO:0001308 +xref: TGMA:0001840 +xref: VHOG:0001758 +xref: Wikipedia:Body_part +xref: XAO:0003013 +xref: ZFA:0001308 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: BFO:0000051 UBERON:0000075 {gci_filler="NCBITaxon:7742", gci_relation="BFO:0000050"} ! has part subdivision of skeletal system @@ -32790,29 +43702,52 @@ relationship: RO:0002131 UBERON:0001015 {gci_filler="NCBITaxon:6072", gci_relati relationship: RO:0002131 UBERON:0001016 {gci_filler="NCBITaxon:6072", gci_relation="RO:0002162"} ! overlaps nervous system relationship: RO:0002131 UBERON:0001434 {gci_filler="NCBITaxon:33213", gci_relation="RO:0002162"} ! overlaps skeletal system relationship: RO:0002131 UBERON:0002416 {gci_filler="NCBITaxon:6072", gci_relation="RO:0002162"} ! overlaps integumental system -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000476 name: acellular anatomical structure +def: "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010268 +xref: AEO:0000040 +xref: BILA:0000040 +xref: CARO:0000040 +xref: EHDAA2:0003040 +xref: FMA:63863 +xref: HAO:0000040 +xref: TAO:0000382 +xref: TGMA:0001841 +xref: XAO:0003162 +xref: ZFA:0000382 is_a: UBERON:0000061 ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000477 name: anatomical cluster +def: "Anatomical group whose component anatomical structures lie in close proximity to each other." [FBbt:00007277] +xref: VHOG:0001737 is_a: UBERON:0034923 ! disconnected anatomical group -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000478 name: extraembryonic structure +def: "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." [CARO:DOS, http://orcid.org/0000-0001-9114-8737, https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279] +comment: see also conceptus extraembryonic component in EHDAA2. +xref: AAO:0010020 +xref: AEO:0000042 +xref: BILA:0000042 +xref: CALOHA:TS-2119 +xref: CARO:0000042 +xref: EHDAA2:0003042 +xref: EHDAA:46 +xref: FMA:85537 +xref: HAO:0000042 +xref: NCIT:C34055 +xref: SCTID:314908006 +xref: TAO:0000020 +xref: TGMA:0001843 +xref: VHOG:0000292 +xref: XAO:0004005 +xref: ZFA:0000020 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component @@ -32822,26 +43757,77 @@ relationship: RO:0002491 UBERON:0000068 {gci_filler="NCBITaxon:6072", gci_relati [Term] id: UBERON:0000479 name: tissue +def: "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." [CARO:0000043] +xref: AAO:0000607 +xref: AAO:0010054 +xref: AEO:0000043 +xref: BILA:0000043 +xref: BIRNLEX:19 +xref: CALOHA:TS-2090 +xref: CARO:0000043 +xref: EHDAA2:0003043 +xref: EMAPA:35868 +xref: FMA:9637 +xref: galen:Tissue +xref: HAO:0000043 +xref: MA:0003002 +xref: MESH:D014024 +xref: NCIT:C12801 +xref: TAO:0001477 +xref: TGMA:0001844 +xref: VHOG:0001757 +xref: WBbt:0005729 +xref: XAO:0003040 +xref: ZFA:0001477 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism relationship: BFO:0000051 GO:0031012 ! has part extracellular matrix -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000481 name: multi-tissue structure +def: "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." [CARO:0000055, http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010048 +xref: AEO:0000055 +xref: BILA:0000055 +xref: CARO:0000055 +xref: EHDAA2:0003055 +xref: HAO:0000055 +xref: TAO:0001488 +xref: TGMA:0001847 +xref: VHOG:0001762 +xref: XAO:0003037 +xref: ZFA:0001488 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 NCBITaxon:6072 {gci_filler="NCBITaxon:6072", gci_relation="RO:0002162"} ! part of Eumetazoa relationship: BFO:0000051 UBERON:0000479 ! has part tissue -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0000483 name: epithelium +def: "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." [http://orcid.org/0000-0001-9114-8737, Wikipedia:Epithelium] +comment: Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it? +xref: AAO:0000144 +xref: AAO:0010055 +xref: AEO:0000066 +xref: BILA:0000066 +xref: BTO:0000416 +xref: CALOHA:TS-0288 +xref: CARO:0000066 +xref: EHDAA2:0003066 +xref: EMAPA:32738 +xref: FMA:9639 +xref: GAID:402 +xref: HAO:0000066 +xref: MA:0003060 +xref: MESH:D004848 +xref: NCIT:C12710 +xref: SCTID:31610004 +xref: TAO:0001486 +xref: VHOG:0000387 +xref: Wikipedia:Epithelium +xref: XAO:0003045 +xref: ZFA:0001486 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002473 CL:0000066 ! epithelial cell @@ -32855,23 +43841,79 @@ relationship: RO:0002473 CL:0000066 ! epithelial cell [Term] id: UBERON:0000484 name: simple cuboidal epithelium +def: "Unilaminar epithelium that consists of a single layer of cuboidal cells." [http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_cuboidal_epithelium] +xref: AAO:0010064 +xref: AEO:0000067 +xref: BILA:0000067 +xref: CARO:0000067 +xref: EHDAA2:0003067 +xref: FMA:45566 +xref: HAO:0000067 +xref: NCIT:C33553 +xref: TAO:0001497 +xref: Wikipedia:Simple_cuboidal_epithelium +xref: XAO:0004009 +xref: ZFA:0001497 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0010077 ! cuboidal epithelium [Term] id: UBERON:0000485 name: simple columnar epithelium +def: "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]." [FMA:FMA, http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_columnar_epithelium] +xref: AAO:0010063 +xref: AEO:0000068 +xref: BILA:0000068 +xref: CARO:0000068 +xref: EHDAA2_RETIRED:0003068 +xref: FMA:45567 +xref: HAO:0000068 +xref: NCIT:C33552 +xref: SCTID:32210007 +xref: TAO:0001496 +xref: Wikipedia:Simple_columnar_epithelium +xref: XAO:0004008 +xref: ZFA:0001496 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0012274 ! columnar epithelium [Term] id: UBERON:0000486 name: multilaminar epithelium +def: "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]." [FMA:FMA, http://orcid.org/0000-0001-9114-8737, Wikipedia:Stratified_epithelium] +xref: AAO:0010059 +xref: AEO:0000069 +xref: BILA:0000069 +xref: BTO:0002074 +xref: CARO:0000069 +xref: EHDAA2:0003069 +xref: FMA:45562 +xref: HAO:0000069 +xref: NCIT:C33622 +xref: SCTID:309044005 +xref: TAO:0001494 +xref: Wikipedia:Stratified_epithelium +xref: XAO:0004006 +xref: ZFA:0001494 is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0000487 name: simple squamous epithelium +def: "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]." [FMA:45565, http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_squamous_epithelium] +xref: AAO:0010066 +xref: AEO:0000070 +xref: BILA:0000070 +xref: BTO:0002073 +xref: CARO:0000070 +xref: EHDAA2:0003070 +xref: FMA:45565 +xref: HAO:0000070 +xref: NCIT:C13178 +xref: TAO:0001498 +xref: Wikipedia:Simple_squamous_epithelium +xref: XAO:0004010 +xref: ZFA:0001498 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0000490 ! unilaminar epithelium @@ -32880,11 +43922,35 @@ intersection_of: BFO:0000051 CL:0000076 ! has part squamous epithelial cell [Term] id: UBERON:0000488 name: atypical epithelium +def: "Epithelium that consists of epithelial cells not arranged in one ore more layers." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010057 +xref: AEO:0000071 +xref: BILA:0000071 +xref: CARO:0000071 +xref: EHDAA2:0003071 +xref: FMA:61741 +xref: HAO:0000071 +xref: TAO:0001493 +xref: XAO:0004004 +xref: ZFA:0001493 is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0000489 name: cavitated compound organ +def: "Compound organ that contains one or more macroscopic anatomical spaces." [http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010016 +xref: AEO:0000072 +xref: BILA:0000072 +xref: CARO:0000072 +xref: EHDAA2:0003072 +xref: FMA:55671 +xref: HAO:0000072 +xref: TAO:0001490 +xref: TGMA:0001857 +xref: VHOG:0001730 +xref: XAO:0003165 +xref: ZFA:0001490 is_a: UBERON:0003103 ! compound organ intersection_of: UBERON:0003103 ! compound organ intersection_of: BFO:0000051 UBERON:0002553 ! has part anatomical cavity @@ -32893,11 +43959,49 @@ relationship: BFO:0000051 UBERON:0002553 ! has part anatomical cavity [Term] id: UBERON:0000490 name: unilaminar epithelium +def: "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]." [FMA:45561, http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010062 +xref: AEO:0000073 +xref: BILA:0000073 +xref: BTO:0002073 +xref: CARO:0000073 +xref: EHDAA2:0003073 +xref: FMA:45561 +xref: HAO:0000073 +xref: NCIT:C33554 +xref: SCTID:309043004 +xref: TAO:0001495 +xref: XAO:0004007 +xref: ZFA:0001495 is_a: UBERON:0000483 ! epithelium +[Term] +id: UBERON:0000912 +name: mucus +def: "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water." [Wikipedia:Mucus] +xref: CALOHA:TS-2144 +xref: ENVO:02000040 +xref: FMA:66938 +xref: GAID:1164 +xref: galen:Mucus +xref: MESH:D009093 +xref: NCIT:C13259 +xref: Wikipedia:Mucus +is_a: UBERON:0000456 ! secretion of exocrine gland +is_a: UBERON:0006314 ! bodily fluid +relationship: BFO:0000051 CHEBI:37395 ! has part +relationship: RO:0000086 PATO:0000998 +relationship: RO:0003001 UBERON:0000344 ! produced by mucosa + [Term] id: UBERON:0000915 name: thoracic segment of trunk +def: "Subdivision of trunk that lies between the head and the abdomen." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:35862 +xref: FMA:259209 +xref: MA:0000022 +xref: SCTID:302551006 +xref: Wikipedia:Thorax is_a: UBERON:0009569 ! subdivision of trunk is_a: UBERON:0011676 ! subdivision of organism along main body axis intersection_of: UBERON:0011676 ! subdivision of organism along main body axis @@ -32907,6 +44011,21 @@ relationship: RO:0002551 UBERON:0014477 ! thoracic skeleton [Term] id: UBERON:0000916 name: abdomen +def: "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000020 +xref: CALOHA:TS-0001 +xref: EFO:0000968 +xref: EMAPA:35102 +xref: EV:0100011 +xref: FMA:9577 +xref: GAID:16 +xref: galen:Abdomen +xref: MA:0000029 +xref: MAT:0000298 +xref: MESH:D000005 +xref: MIAA:0000298 +xref: SCTID:302553009 +xref: Wikipedia:Abdomen is_a: UBERON:0009569 ! subdivision of trunk relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -32914,6 +44033,31 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0000922 name: embryo +def: "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [BTO:0000379, FB:FBrf0039741, FB:FBrf0041814, GO:0009790, Wikipedia:Embryo] +xref: AAO:0011035 +xref: AEO:0000169 +xref: BILA:0000056 +xref: BSA:0000039 +xref: BTO:0000379 +xref: CALOHA:TS-0229 +xref: EFO:0001367 +xref: EHDAA2:0000002 +xref: EHDAA2_RETIRED:0003236 +xref: EHDAA:38 +xref: EMAPA:16039 +xref: FMA:69068 +xref: GAID:963 +xref: http://neurolex.org/wiki/Category\:Embryonic_organism +xref: MAT:0000226 +xref: MESH:D004622 +xref: MIAA:0000019 +xref: NCIT:C28147 +xref: OGEM:000001 +xref: SCTID:57991002 +xref: VHOG:0001766 +xref: Wikipedia:Embryo +xref: XAO:0000113 +xref: ZFA:0000103 is_a: UBERON:0000468 ! multicellular organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002489 UBERON:0000068 ! embryo stage @@ -32924,12 +44068,50 @@ relationship: RO:0002493 UBERON:0000068 ! embryo stage [Term] id: UBERON:0000923 name: germ layer +def: "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm." [https://github.com/obophenotype/uberon/issues/203, Wikipedia:Germ_layer] +comment: Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest] +xref: AAO:0000480 +xref: BILA:0000035 +xref: BTO:0000556 +xref: EMAPA:36033 +xref: FMA:69069 +xref: GAID:1303 +xref: MESH:D005855 +xref: NCIT:C12950 +xref: NCIT:C54105 +xref: TAO:0001122 +xref: VHOG:0001223 +xref: Wikipedia:Germ_layer +xref: XAO:0003011 +xref: ZFA:0001122 is_a: UBERON:0010316 ! germ layer / neural crest relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0000924 name: ectoderm +def: "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." [Wikipedia:Ectoderm] +xref: AAO:0000137 +xref: BILA:0000036 +xref: BTO:0000315 +xref: CALOHA:TS-0216 +xref: EFO:0000414 +xref: EHDAA2:0000428 +xref: EMAPA:16069 +xref: EV:0100003 +xref: FMA:69070 +xref: GAID:1304 +xref: MAT:0000155 +xref: MAT:0000173 +xref: MESH:D004475 +xref: MIAA:0000173 +xref: NCIT:C12703 +xref: SCTID:362851007 +xref: TAO:0000016 +xref: VHOG:0000153 +xref: Wikipedia:Ectoderm +xref: XAO:0000001 +xref: ZFA:0000016 is_a: UBERON:0000923 ! germ layer relationship: BFO:0000051 CL:0000221 ! has part ectodermal cell relationship: RO:0002495 UBERON:0006601 ! presumptive ectoderm @@ -32937,6 +44119,27 @@ relationship: RO:0002495 UBERON:0006601 ! presumptive ectoderm [Term] id: UBERON:0000925 name: endoderm +def: "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut." [Wikipedia:Endoderm] +xref: AAO:0000139 +xref: BILA:0000038 +xref: BTO:0000800 +xref: CALOHA:TS-0273 +xref: EFO:0002545 +xref: EHDAA2:0000436 +xref: EMAPA:16062 +xref: EV:0100005 +xref: FMA:69071 +xref: GAID:1305 +xref: MAT:0000175 +xref: MESH:D004707 +xref: MIAA:0000175 +xref: NCIT:C12706 +xref: SCTID:362855003 +xref: TAO:0000017 +xref: VHOG:0000154 +xref: Wikipedia:Endoderm +xref: XAO:0000090 +xref: ZFA:0000017 is_a: UBERON:0000923 ! germ layer relationship: BFO:0000051 CL:0000223 ! has part endodermal cell relationship: RO:0002495 UBERON:0006595 ! presumptive endoderm @@ -32944,6 +44147,30 @@ relationship: RO:0002495 UBERON:0006595 ! presumptive endoderm [Term] id: UBERON:0000926 name: mesoderm +def: "The middle germ layer of the embryo, between the endoderm and ectoderm." [Wikipedia:Mesoderm] +xref: AAO:0000304 +xref: BILA:0000037 +xref: BTO:0000839 +xref: CALOHA:TS-0623 +xref: EFO:0001981 +xref: EHDAA2:0001128 +xref: EHDAA:124 +xref: EHDAA:160 +xref: EHDAA:183 +xref: EMAPA:16083 +xref: EV:0100006 +xref: FMA:69072 +xref: GAID:522 +xref: MAT:0000174 +xref: MESH:D008648 +xref: MIAA:0000174 +xref: NCIT:C12750 +xref: SCTID:362854004 +xref: TAO:0000041 +xref: VHOG:0000152 +xref: Wikipedia:Mesoderm +xref: XAO:0000050 +xref: ZFA:0000041 is_a: UBERON:0000923 ! germ layer relationship: BFO:0000051 CL:0000222 ! has part mesodermal cell relationship: RO:0002495 UBERON:0006603 ! presumptive mesoderm @@ -32951,35 +44178,131 @@ relationship: RO:0002495 UBERON:0006603 ! presumptive mesoderm [Term] id: UBERON:0000930 name: stomodeum +def: "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/326, Wikipedia:Stomodeum] +xref: BTO:0004224 +xref: EHDAA2:0001929 +xref: EMAPA:16263 +xref: FMA:295846 +xref: NCIT:C34306 +xref: TAO:0001290 +xref: TGMA:0000135 +xref: Wikipedia:Stomodeum +xref: XAO:0000269 +xref: ZFA:0001290 is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm relationship: BFO:0000050 UBERON:0035804 ! part of future mouth relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa +[Term] +id: UBERON:0000931 +name: proctodeum +def: "Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract." [https://github.com/obophenotype/uberon/issues/685, https://sourceforge.net/p/fbbtdv/tickets/52, ZFA:0000066] +xref: AAO:0011087 +xref: EHDAA2:0000121 +xref: EMAPA:25038 +xref: NCIT:C34278 +xref: TAO:0000066 +xref: VHOG:0000139 +xref: Wikipedia:Proctodeum +xref: XAO:0001019 +xref: ZFA:0000066 +is_a: UBERON:0016566 ! pit +relationship: BFO:0000050 UBERON:0007026 ! part of presumptive gut +relationship: RO:0001025 UBERON:0012469 ! external anal region +relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa +relationship: RO:0002202 UBERON:0000924 ! ectoderm +relationship: RO:0002387 UBERON:0001353 ! anal region + [Term] id: UBERON:0000945 name: stomach +def: "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584, Wikipedia:Stomach] +xref: AAO:0000579 +xref: ANISEED:1235297 +xref: BTO:0001307 +xref: CALOHA:TS-0980 +xref: EFO:0000837 +xref: EHDAA2:0001915 +xref: EHDAA:2993 +xref: EMAPA:17021 +xref: EV:0100070 +xref: FMA:7148 +xref: GAID:293 +xref: galen:Stomach +xref: MA:0000353 +xref: MAT:0000051 +xref: MESH:D013270 +xref: MIAA:0000051 +xref: NCIT:C12391 +xref: SCTID:181246003 +xref: TAO:0002121 +xref: VHOG:0000408 +xref: Wikipedia:Stomach +xref: XAO:0000128 is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0010039 ! food storage organ relationship: BFO:0000050 UBERON:0001041 ! part of foregut relationship: RO:0002160 NCBITaxon:7776 ! Gnathostomata relationship: RO:0002215 GO:0001696 ! capable of gastric acid secretion relationship: RO:0002433 UBERON:0001007 ! digestive system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000947 name: aorta +def: "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MESH:A07.231.114.056, MP:0000272, Wikipedia:Aorta] +xref: AAO:0010213 +xref: BTO:0000135 +xref: CALOHA:TS-0046 +xref: EFO:0000265 +xref: EMAPA:18601 +xref: EV:0100027 +xref: FMA:3734 +xref: GAID:469 +xref: galen:Aorta +xref: MA:0000062 +xref: MAT:0000035 +xref: MESH:D001011 +xref: MIAA:0000035 +xref: NCIT:C12669 +xref: SCTID:181298001 +xref: VHOG:0001523 +xref: Wikipedia:Aorta +xref: XAO:0003010 is_a: UBERON:0003509 ! arterial blood vessel is_a: UBERON:0003519 ! thoracic cavity blood vessel is_a: UBERON:0013768 ! great vessel of heart relationship: BFO:0000050 UBERON:0010191 ! part of aortic system relationship: RO:0002170 UBERON:0002084 ! heart left ventricle -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000948 name: heart +def: "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Heart] +comment: Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 +xref: AAO:0010210 +xref: BILA:0000020 +xref: BTO:0000562 +xref: CALOHA:TS-0445 +xref: EFO:0000815 +xref: EHDAA2:0000738 +xref: EHDAA:420 +xref: EMAPA:16105 +xref: EV:0100018 +xref: FMA:7088 +xref: GAID:174 +xref: galen:Heart +xref: MA:0000072 +xref: MAT:0000036 +xref: MESH:D006321 +xref: MIAA:0000036 +xref: NCIT:C12727 +xref: SCTID:302509004 +xref: TAO:0000114 +xref: VHOG:0000276 +xref: Wikipedia:Heart +xref: XAO:0000064 +xref: ZFA:0000114 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0007100 ! primary circulatory organ @@ -32991,11 +44314,28 @@ relationship: BFO:0000051 UBERON:0004151 ! has part cardiac chamber relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002202 UBERON:0004141 ! heart tube relationship: RO:0002433 UBERON:0004535 ! cardiovascular system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000949 name: endocrine system +def: "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity." [NLM:endocrine+system, Wikipedia:Endocrine_system] +xref: AAO:0010279 +xref: CALOHA:TS-1301 +xref: EFO:0002969 +xref: EHDAA2:0002224 +xref: EMAPA:35306 +xref: EV:0100128 +xref: FMA:9668 +xref: GAID:439 +xref: MA:0000012 +xref: MESH:D004703 +xref: NCIT:C12705 +xref: SCTID:278876000 +xref: TAO:0001158 +xref: VHOG:0000098 +xref: Wikipedia:Endocrine_system +xref: XAO:0000158 +xref: ZFA:0001158 is_a: UBERON:0015204 ! glandular system disjoint_from: UBERON:0000990 ! reproductive system disjoint_from: UBERON:0001004 ! respiratory system @@ -33004,10 +44344,12 @@ disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa @@ -33017,20 +44359,56 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0000955 name: brain +def: "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Brain] +xref: AAO:0010478 +xref: ABA:Brain +xref: BAMS:Br +xref: BAMS:Brain +xref: BILA:0000135 +xref: BIRNLEX:796 +xref: BTO:0000142 +xref: CALOHA:TS-0095 +xref: DHBA:10155 +xref: EFO:0000302 +xref: EHDAA2:0000183 +xref: EHDAA:2641 +xref: EHDAA:6485 +xref: EMAPA:16894 +xref: EV:0100164 +xref: FMA:50801 +xref: GAID:571 +xref: galen:Brain +xref: HBA:4005 +xref: MA:0000168 +xref: MAT:0000098 +xref: MBA:8 +xref: MBA:997 +xref: MESH:D001921 +xref: MIAA:0000098 +xref: NCIT:C12439 +xref: PBA:3999 +xref: SCTID:258335003 +xref: TAO:0000008 +xref: VHOG:0000157 +xref: Wikipedia:Brain +xref: XAO:0000010 +xref: ZFA:0000008 is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BSPO:0000123 UBERON:0000468 ! multicellular organism relationship: RO:0002202 UBERON:0001049 {gci_filler="NCBITaxon:7711", gci_relation="BFO:0000050"} ! neural tube +relationship: RO:0002215 GO:0050890 {gci_filler="NCBITaxon:9606", gci_relation="BFO:0000050"} ! capable of cognition relationship: RO:0002433 UBERON:0001016 ! nervous system relationship: RO:0002473 CL:0002319 ! neural cell relationship: RO:0002492 UBERON:0000066 ! fully formed stage relationship: RO:0002495 UBERON:0006238 ! future brain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000957 name: lamina +def: "Any thin layer or plate." [Wikipedia:Lamina_of_the_vertebral_arch] +xref: Wikipedia:Lamina_of_the_vertebral_arch is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0000086 PATO:0002124 @@ -33039,15 +44417,25 @@ relationship: RO:0000086 PATO:0002124 [Term] id: UBERON:0000962 name: nerve of cervical vertebra +def: "The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]." [Wikipedia:Cervical_nerves] +comment: Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP] +xref: BAMS:cern +xref: FMA:5859 +xref: NCIT:C32299 +xref: neuronames:2351 +xref: NLXANAT:20090207 +xref: SCTID:360497008 +xref: Wikipedia:Cervical_nerves is_a: UBERON:0001780 ! spinal nerve intersection_of: UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0002726 ! cervical spinal cord relationship: extends_fibers_into UBERON:0002726 ! cervical spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000963 name: head sensillum +xref: MAT:0000204 +xref: MIAA:0000204 is_a: UBERON:0002536 ! arthropod sensillum intersection_of: UBERON:0002536 ! arthropod sensillum intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -33056,6 +44444,26 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0000964 name: cornea +def: "The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure." [ISBN:0-683-40008-8, MESH:A09.371.060.217, MP:0001312] +xref: AAO:0010344 +xref: BTO:0000286 +xref: CALOHA:TS-0171 +xref: EFO:0000377 +xref: EHDAA2:0000316 +xref: EHDAA:10199 +xref: EMAPA:17161 +xref: EV:0100341 +xref: FMA:58238 +xref: GAID:892 +xref: MA:0000266 +xref: MESH:D003315 +xref: NCIT:C12342 +xref: SCTID:181162001 +xref: TAO:0000640 +xref: VHOG:0000164 +xref: Wikipedia:Cornea +xref: XAO:0000180 +xref: ZFA:0000640 is_a: UBERON:0010000 ! multicellular anatomical structure is_a: UBERON:0010313 ! neural crest-derived structure relationship: BFO:0000050 UBERON:0001801 ! part of anterior segment of eyeball @@ -33069,22 +44477,69 @@ relationship: RO:0002202 UBERON:0004348 ! optic eminence relationship: RO:0002202 UBERON:0005427 ! corneal primordium relationship: RO:0002256 UBERON:0005426 ! lens vesicle relationship: RO:0002433 UBERON:0001801 ! anterior segment of eyeball -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000965 name: lens of camera-type eye +def: "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lens_(anatomy)] +comment: The lens is avascular and nourished by diffusion from the aqueous and vitreous humors. +xref: AAO:0010348 +xref: BTO:0000723 +xref: CALOHA:TS-0545 +xref: EHDAA:9057 +xref: EMAPA:17838 +xref: EV:0100343 +xref: FMA:58241 +xref: MA:0000275 +xref: MAT:0000141 +xref: MESH:D007908 +xref: MIAA:0000141 +xref: NCIT:C12743 +xref: RETIRED_EHDAA2:0000975 +xref: SCTID:181169005 +xref: TAO:0000035 +xref: VHOG:0000169 +xref: Wikipedia:Lens_(anatomy) +xref: XAO:0000008 +xref: ZFA:0000035 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005389 ! transparent eye structure relationship: BFO:0000050 UBERON:0001801 ! part of anterior segment of eyeball relationship: RO:0002202 UBERON:0005426 ! lens vesicle relationship: RO:0002256 UBERON:0003902 ! retinal neural layer relationship: RO:0002433 UBERON:0001801 ! anterior segment of eyeball -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000966 name: retina +def: "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [Wikipedia:Retina, ZFIN:curator] +comment: Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods +xref: AAO:0010352 +xref: BAMS:R +xref: BIRNLEX:1153 +xref: BTO:0001175 +xref: CALOHA:TS-0865 +xref: EFO:0000832 +xref: EHDAA2:0001627 +xref: EHDAA:4757 +xref: EMAPA:17168 +xref: EV:0100348 +xref: FMA:58301 +xref: GAID:755 +xref: MA:0000276 +xref: MAT:0000142 +xref: MBA:304325711 +xref: MESH:D012160 +xref: MIAA:0000142 +xref: NCIT:C12343 +xref: neuronames:1862 +xref: NIFSTD_RETIRED:birnlex_1156 +xref: SCTID:181171005 +xref: TAO:0000152 +xref: VHOG:0000229 +xref: Wikipedia:Retina +xref: XAO:0000009 +xref: ZFA:0000152 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005388 ! photoreceptor array relationship: BFO:0000050 UBERON:0001802 ! part of posterior segment of eyeball @@ -33093,21 +44548,36 @@ relationship: BFO:0000051 CL:0000573 ! has part retinal cone cell relationship: BFO:0000051 CL:0000604 ! has part retinal rod cell relationship: BFO:0000051 CL:0000740 ! has part retinal ganglion cell relationship: RO:0002202 UBERON:0003072 ! optic cup -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000970 name: eye +def: "An organ that detects light." [https://orcid.org/0000-0002-6601-2165] +xref: BILA:0000017 +xref: BTO:0000439 +xref: CALOHA:TS-0309 +xref: EFO:0000827 +xref: EV:0100336 +xref: GAID:69 +xref: MAT:0000140 +xref: MESH:D005123 +xref: MIAA:0000140 +xref: Wikipedia:Eye is_a: UBERON:0000020 ! sense organ relationship: BFO:0000050 UBERON:0002104 ! part of visual system relationship: BFO:0000051 CL:0000149 ! has part visual pigment cell relationship: BFO:0000051 CL:0000210 ! has part photoreceptor cell relationship: RO:0002215 GO:0009584 ! capable of detection of visible light -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000971 name: ommatidium +def: "The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells." [PMID:21062451] +xref: BTO:0001922 +xref: HAO:0000666 +xref: MAT:0000143 +xref: MIAA:0000143 +xref: Wikipedia:Ommatidium is_a: UBERON:0000970 ! eye is_a: UBERON:0002536 ! arthropod sensillum relationship: BFO:0000050 UBERON:0000018 ! part of compound eye @@ -33115,6 +44585,23 @@ relationship: BFO:0000050 UBERON:0000018 ! part of compound eye [Term] id: UBERON:0000974 name: neck +def: "An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column." [http://orcid.org/0000-0002-6601-2165] +xref: AEO:0000108 +xref: BTO:0000420 +xref: CALOHA:TS-2045 +xref: EFO:0000967 +xref: EHDAA2:0003108 +xref: EMAPA:35587 +xref: FMA:7155 +xref: GAID:86 +xref: galen:Neck +xref: MA:0000024 +xref: MAT:0000297 +xref: MESH:D009333 +xref: MIAA:0000297 +xref: NCIT:C13063 +xref: SCTID:302550007 +xref: Wikipedia:Neck is_a: UBERON:0000475 ! organism subdivision relationship: anteriorly_connected_to UBERON:0000033 ! head relationship: BFO:0000050 UBERON:0000153 ! part of anterior region of body @@ -33123,6 +44610,19 @@ relationship: posteriorly_connected_to UBERON:0002100 ! trunk [Term] id: UBERON:0000977 name: pleura +def: "The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion)." [https://github.com/obophenotype/uberon/issues/1231, ISBN:0-683-40008-8, MP:0010820, UBERON:cjm, Wikipedia:Pulmonary_pleurae] +xref: BTO:0001791 +xref: CALOHA:TS-2081 +xref: EFO:0001980 +xref: EV:0100044 +xref: FMA:9583 +xref: GAID:360 +xref: MA:0000433 +xref: MESH:D010994 +xref: NCIT:C12469 +xref: SCTID:181609007 +xref: VHOG:0000394 +xref: Wikipedia:Pleura is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure intersection_of: UBERON:0000042 ! serous membrane @@ -33140,6 +44640,28 @@ relationship: RO:0002433 UBERON:0001004 ! respiratory system [Term] id: UBERON:0000982 name: skeletal joint +def: "Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000101, Wikipedia:Joint] +xref: AEO:0000182 +xref: BTO:0001686 +xref: CALOHA:TS-2023 +xref: EFO:0000948 +xref: EMAPA:35456 +xref: FMA:7490 +xref: GAID:102 +xref: galen:Joint +xref: MA:0000319 +xref: MAT:0000188 +xref: MESH:D007596 +xref: MIAA:0000188 +xref: NCIT:C13044 +xref: RETIRED_EHDAA2:0003182 +xref: SCTID:302536002 +xref: TAO:0000367 +xref: VHOG:0001276 +xref: VSAO:0000101 +xref: Wikipedia:Joint +xref: XAO:0000171 +xref: ZFA:0001596 is_a: UBERON:0004905 ! articulation union_of: UBERON:0002217 ! synovial joint union_of: UBERON:0011134 ! nonsynovial joint @@ -33150,17 +44672,64 @@ relationship: RO:0002433 UBERON:0001434 ! skeletal system [Term] id: UBERON:0000988 name: pons +def: "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum." [VHOG:0001176] +xref: BAMS:PONS +xref: BAMS:Pons +xref: BIRNLEX:733 +xref: BM:Pons +xref: BTO:0001101 +xref: CALOHA:TS-0813 +xref: DHBA:10661 +xref: EFO:0001394 +xref: EHDAA2:0004394 +xref: EMAPA:17563 +xref: EV:0100253 +xref: FMA:67943 +xref: GAID:578 +xref: HBA:9131 +xref: MA:0000204 +xref: MAT:0000115 +xref: MBA:771 +xref: MESH:D011149 +xref: MIAA:0000115 +xref: NCIT:C12511 +xref: SCTID:279103004 +xref: VHOG:0001176 +xref: Wikipedia:Pons is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001895 ! part of metencephalon relationship: BFO:0000050 UBERON:0002298 ! part of brainstem relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002433 UBERON:0001895 ! metencephalon relationship: RO:0002433 UBERON:0002298 ! brainstem -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000990 name: reproductive system +def: "Anatomical system that has as its parts the organs concerned with reproduction." [Wikipedia:Reproductive_system] +xref: AAO:0010258 +xref: BILA:0000103 +xref: BTO:0000081 +xref: CALOHA:TS-1318 +xref: EFO:0000809 +xref: EHDAA2:0001603 +xref: EHDAA:5923 +xref: EMAPA:17381 +xref: EV:0100100 +xref: FMA:7160 +xref: GAID:363 +xref: HAO:0000374 +xref: HAO:0000895 +xref: MA:0000326 +xref: MIAA:0000305 +xref: NCIT:C12841 +xref: SCTID:278875001 +xref: TAO:0000632 +xref: VHOG:0000182 +xref: WBbt:0005747 +xref: Wikipedia:Reproductive_system +xref: XAO:0000142 +xref: ZFA:0000632 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002216 GO:0022414 ! capable of part of reproductive process @@ -33170,20 +44739,40 @@ disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 UBERON:0000991 ! has part gonad relationship: RO:0002216 GO:0022414 ! capable of part of reproductive process relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0000991 name: gonad +def: "Reproductive organ that produces and releases eggs (ovary) or sperm (testis)." [ISBN:0140512888, Wikipedia:Gonad, ZFA:0000413, ZFIN:curator] +xref: AAO:0000213 +xref: BILA:0000123 +xref: BSA:0000079 +xref: BTO:0000534 +xref: EMAPA:17383 +xref: FMA:18250 +xref: GAID:368 +xref: HAO:0000379 +xref: MA:0002420 +xref: MESH:D006066 +xref: NCIT:C12725 +xref: SCTID:304623008 +xref: TAO:0000413 +xref: VHOG:0000397 +xref: WBbt:0005175 +xref: Wikipedia:Gonad +xref: XAO:0003146 +xref: ZFA:0000413 is_a: UBERON:0003133 ! reproductive organ intersection_of: UBERON:0003133 ! reproductive organ intersection_of: BFO:0000051 CL:0000586 ! has part germ cell @@ -33194,6 +44783,29 @@ relationship: RO:0002202 UBERON:0005564 ! gonad primordium [Term] id: UBERON:0000992 name: ovary +def: "The gonad of a female organism which contains germ cells." [ISBN:0-683-40008-8, MP:0001126, Wikipedia:Ovary] +xref: AAO:0000371 +xref: BILA:0000125 +xref: BSA:0000080 +xref: BTO:0000975 +xref: CALOHA:TS-0730 +xref: EFO:0000973 +xref: EHDAA2:0001360 +xref: EHDAA:8124 +xref: EMAPA:17962 +xref: EV:0100111 +xref: FMA:7209 +xref: GAID:367 +xref: MA:0000384 +xref: MESH:D010053 +xref: MIAA:0000125 +xref: NCIT:C12404 +xref: SCTID:181464007 +xref: TAO:0000403 +xref: VHOG:0000251 +xref: Wikipedia:Ovary +xref: XAO:0000258 +xref: ZFA:0000403 is_a: UBERON:0000991 ! gonad is_a: UBERON:0003134 ! female reproductive organ intersection_of: UBERON:0000991 ! gonad @@ -33201,11 +44813,30 @@ intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system disjoint_from: UBERON:0009117 ! indifferent gonad relationship: RO:0002160 NCBITaxon:33208 ! Metazoa relationship: RO:0002202 UBERON:0009117 ! indifferent gonad -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001003 name: skin epidermis +def: "The outer epithelial layer of the skin that is superficial to the dermis." [http://orcid.org/0000-0002-6601-2165, ISBN:0073040584] +xref: AAO:0000143 +xref: BTO:0000404 +xref: CALOHA:TS-0283 +xref: EFO:0000954 +xref: EMAPA:17528 +xref: EV:0100153 +xref: FMA:70596 +xref: GAID:932 +xref: MA:0000153 +xref: MAT:0000154 +xref: MESH:D004817 +xref: MIAA:0000154 +xref: NCIT:C12708 +xref: SCTID:361694003 +xref: TAO:0000105 +xref: VHOG:0000077 +xref: Wikipedia:Epidermis_(skin) +xref: XAO:0000028 +xref: ZFA:0000105 is_a: UBERON:0007376 ! outer epithelium is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:0007376 ! outer epithelium @@ -33213,11 +44844,32 @@ intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: RO:0002220 UBERON:0002067 ! adjacent to dermis relationship: RO:0002285 UBERON:0003055 ! periderm -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001004 name: respiratory system +def: "Functional system which consists of structures involved in respiration." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Respiratory_system] +xref: AAO:0000541 +xref: BTO:0000203 +xref: CALOHA:TS-1319 +xref: EFO:0000804 +xref: EHDAA2:0001604 +xref: EHDAA:2203 +xref: EMAPA:16727 +xref: EV:0100036 +xref: FMA:7158 +xref: GAID:78 +xref: MA:0000327 +xref: MAT:0000030 +xref: MESH:D012137 +xref: MIAA:0000030 +xref: NCIT:C12779 +xref: SCTID:278197002 +xref: TAO:0000272 +xref: VHOG:0000202 +xref: Wikipedia:Respiratory_system +xref: XAO:0000117 +xref: ZFA:0000272 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system @@ -33226,21 +44878,25 @@ disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002160 NCBITaxon:33213 ! Bilateria relationship: RO:0002215 GO:0003016 ! capable of respiratory system process relationship: RO:0002215 GO:0007585 ! capable of respiratory gaseous exchange by respiratory system relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001005 name: respiratory airway +def: "An airway through which respiratory air passes in organisms." [Wikipedia:Trachea] +xref: SCTID:361380005 +xref: Wikipedia:Trachea is_a: UBERON:0003103 ! compound organ is_a: UBERON:0004111 ! anatomical conduit relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -33249,6 +44905,27 @@ relationship: channel_for UBERON:0034874 ! air in respiratory system [Term] id: UBERON:0001007 name: digestive system +def: "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." [FB:gg, NLM:alimentary+system, Wikipedia:Digestive_system] +xref: AAO:0000129 +xref: BILA:0000082 +xref: BTO:0000058 +xref: CALOHA:TS-1293 +xref: EFO:0000793 +xref: FMA:7152 +xref: GAID:278 +xref: galen:DigestiveSystem +xref: MA:0002431 +xref: MAT:0000018 +xref: MESH:D004064 +xref: MIAA:0000018 +xref: ncithesaurus:Digestive_System +xref: SCTID:278859004 +xref: TADS:0000170 +xref: TAO:0000339 +xref: WBbt:0005748 +xref: Wikipedia:Digestive_system +xref: XAO:0000125 +xref: ZFA:0000339 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002215 GO:0022600 ! capable of digestive system process @@ -33256,47 +44933,126 @@ disjoint_from: UBERON:0001009 ! circulatory system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002215 GO:0022600 ! capable of digestive system process relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001008 +name: renal system +def: "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products." [DOI:10.1371/journal.pone.0099864, GO:0072001] +comment: EDITOR_NOTE In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here +xref: AAO:0010257 +xref: BILA:0000015 +xref: BTO:0001244 +xref: BTO:0003092 +xref: CALOHA:TS-1323 +xref: EFO:0000803 +xref: EHDAA2:0001601 +xref: EHDAA:5901 +xref: EMAPA:17366 +xref: EV:0100095 +xref: FMA:7159 +xref: GAID:391 +xref: galen:UrinaryTract +xref: MA:0000325 +xref: MAT:0000027 +xref: MESH:D014551 +xref: MIAA:0000027 +xref: NCIT:C12413 +xref: SCTID:362204003 +xref: TADS:0000162 +xref: TAO:0000163 +xref: VHOG:0000723 +xref: WBbt:0005736 +xref: Wikipedia:Excretory_system +xref: XAO:0000143 +xref: ZFA:0000163 +is_a: UBERON:8450002 ! excretory system +intersection_of: UBERON:8450002 ! excretory system +intersection_of: RO:0002215 GO:0097254 ! capable of renal tubular secretion +relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa +relationship: RO:0002215 GO:0097254 ! capable of renal tubular secretion +relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0001009 name: circulatory system +def: "Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]." [Wikipedia:Circulatory_system] +xref: AAO:0000959 +xref: CALOHA:TS-2103 +xref: VHOG:0001248 +xref: Wikipedia:Circulatory_system is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0001016 ! nervous system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002160 NCBITaxon:33213 ! Bilateria relationship: RO:0002215 GO:0003013 ! capable of circulatory system process relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001013 name: adipose tissue +def: "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue." [http://orcid.org/0000-0002-6601-2165, MESH:A10.165.114, MGI:cwg, MP:0000003, Wikipedia:Adipose_tissue] +xref: AAO:0000001 +xref: AEO:000020 +xref: BTO:0001487 +xref: CALOHA:TS-0013 +xref: EFO:0000790 +xref: EHDAA2:0003120 +xref: EMAPA:35112 +xref: EV:0100381 +xref: FMA:20110 +xref: GAID:920 +xref: galen:FattyTissue +xref: MA:0000009 +xref: MAT:0000015 +xref: MESH:D000273 +xref: MIAA:0000015 +xref: NCIT:C12472 +xref: SCTID:55603005 +xref: TAO:0002134 +xref: VHOG:0001284 +xref: Wikipedia:Adipose_tissue +xref: XAO:0003049 +xref: ZFA:0005345 is_a: UBERON:0011822 ! dense irregular connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002473 CL:0000136 ! adipocyte disjoint_from: UBERON:0003714 ! neural tissue relationship: RO:0002473 CL:0000136 ! adipocyte -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001015 name: musculature +def: "A subdivision of the muscular system corresponding to a subdisivision of an organism." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Muscular_system] +xref: BTO:0000887 +xref: EFO:0001949 +xref: EMAPA:35577 +xref: FMA:32558 +xref: MA:0000165 +xref: NCIT:C13056 +xref: TAO:0000548 +xref: VSAO:0005038 +xref: WBbt:0005737 +xref: Wikipedia:Muscular_system +xref: ZFA:0000548 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0000383 ! part of musculature of body relationship: RO:0002473 UBERON:0001630 ! muscle organ @@ -33304,13 +45060,41 @@ relationship: RO:0002473 UBERON:0001630 ! muscle organ [Term] id: UBERON:0001016 name: nervous system +def: "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." [BIRNLEX:844, ISBN:0-14-051288-8, ISBN:3110148986, NLM:nervous+system, WB:rynl, Wikipedia:Nervous_system, ZFIN:curator] +xref: AAO:0000324 +xref: BILA:0000079 +xref: BIRNLEX:844 +xref: BTO:0001484 +xref: CALOHA:TS-1313 +xref: EFO:0000802 +xref: EHDAA2:0001246 +xref: EHDAA:826 +xref: EMAPA:16469 +xref: EV:0100162 +xref: FMA:7157 +xref: GAID:466 +xref: MA:0000016 +xref: MAT:0000026 +xref: MESH:D009420 +xref: MIAA:0000026 +xref: NCIT:C12755 +xref: neuronames:3236 +xref: SCTID:278196006 +xref: TAO:0000396 +xref: VHOG:0000402 +xref: WBbt:0005735 +xref: Wikipedia:Nervous_system +xref: XAO:0000177 +xref: ZFA:0000396 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0001434 ! skeletal system disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 CL:0000540 ! has part neuron @@ -33319,35 +45103,115 @@ relationship: RO:0002215 GO:0050877 ! capable of nervous system process relationship: RO:0002473 CL:0002319 ! neural cell relationship: RO:0002492 UBERON:0000066 ! fully formed stage relationship: RO:0002495 UBERON:0016880 ! future nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001017 name: central nervous system +def: "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord." [GO:0021551, http://www.frontiersinzoology.com/content/7/1/29, https://sourceforge.net/p/geneontology/ontology-requests/11422/] +xref: AAO:0000090 +xref: BAMS:CNS +xref: BILA:0000080 +xref: BIRNLEX:1099 +xref: BTO:0000227 +xref: CALOHA:TS-0150 +xref: EFO:0000908 +xref: EHDAA2:0000225 +xref: EHDAA:828 +xref: EMAPA:16470 +xref: EMAPA:16754 +xref: EV:0100163 +xref: FMA:55675 +xref: GAID:570 +xref: MA:0000167 +xref: MAT:0000457 +xref: MESH:D002490 +xref: NCIT:C12438 +xref: neuronames:854 +xref: SCTID:278199004 +xref: TAO:0000012 +xref: VHOG:0000293 +xref: Wikipedia:Central_nervous_system +xref: XAO:0000215 +xref: ZFA:0000012 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002160 NCBITaxon:33213 ! Bilateria relationship: RO:0002495 UBERON:0016879 ! future central nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001021 name: nerve +def: "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures." [FBbt:00005105, http://orcid.org/0000-0002-6601-2165] +xref: AAO:0011070 +xref: AEO:0000137 +xref: BAMS:n +xref: BIRNLEX:1615 +xref: BSA:0000098 +xref: BTO:0000925 +xref: BTO:0001027 +xref: CALOHA:TS-0772 +xref: EHDAA2:0003137 +xref: EHDAA:2851 +xref: EHDAA:3776 +xref: EHDAA:4657 +xref: EMAPA:32808 +xref: EMAPA:32815 +xref: EV:0100371 +xref: FMA:65132 +xref: FMA:65239 +xref: GAID:747 +xref: GAID:758 +xref: galen:Nerve +xref: MA:0000217 +xref: MA:0000228 +xref: MESH:D010525 +xref: NCIT:C12466 +xref: NCIT:C12768 +xref: NLX:147826 +xref: SCTID:244457007 +xref: SCTID:256864008 +xref: TAO:0007009 +xref: VHOG:0000901 +xref: Wikipedia:Nervous_system +xref: XAO:0000204 +xref: XAO:0003047 +xref: ZFA:0007009 is_a: UBERON:0000122 ! neuron projection bundle relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system relationship: RO:0000086 PATO:0002045 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001027 name: sensory nerve +def: "A nerve that transmits from sensory receptors on the surface of the body to the central nervous system." [UBERON:cjm, Wikipedia:Sensory_nerve] +xref: AEO:0000201 +xref: EHDAA2:0003200 +xref: FMA:5868 +xref: Wikipedia:Sensory_nerve is_a: UBERON:0001021 ! nerve relationship: BFO:0000051 CL:0000526 ! has part afferent neuron [Term] id: UBERON:0001032 name: sensory system +def: "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information." [Wikipedia:Sensory_system] +xref: AAO:0000555 +xref: BAMS:SEN +xref: BILA:0000099 +xref: EFO:0000805 +xref: EHDAA2:0003094 +xref: EMAPA:16192 +xref: FMA:75259 +xref: MA:0002442 +xref: MAT:0000031 +xref: MIAA:0000031 +xref: NLXANAT:090816 +xref: TAO:0000282 +xref: VHOG:0001674 +xref: Wikipedia:Sensory_system +xref: XAO:0003194 +xref: ZFA:0000282 is_a: UBERON:0015203 ! non-connected functional system relationship: BFO:0000050 UBERON:0004456 ! part of entire sense organ system relationship: RO:0002131 UBERON:0001016 ! overlaps nervous system @@ -33356,6 +45220,20 @@ relationship: RO:0002216 GO:0007600 ! capable of part of sensory perception [Term] id: UBERON:0001040 name: yolk sac +def: "A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]." [Wikipedia:Yolk_sac] +xref: BTO:0001471 +xref: CALOHA:TS-1130 +xref: EFO:0003078 +xref: EHDAA2:0002212 +xref: EHDAA:164 +xref: EMAPA:16085 +xref: FMA:87180 +xref: GAID:1301 +xref: MESH:D015017 +xref: NCIT:C14128 +xref: SCTID:362845002 +xref: VHOG:0000830 +xref: Wikipedia:Yolk_sac is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0005631 ! extraembryonic membrane is_a: UBERON:0007499 ! epithelial sac @@ -33365,11 +45243,48 @@ relationship: RO:0002254 UBERON:0004872 ! splanchnic layer of lateral plate meso [Term] id: UBERON:0001041 name: foregut +def: "Anterior subdivision of a digestive tract." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0011042 +xref: BILA:0000085 +xref: BTO:0000507 +xref: EHDAA2:0000557 +xref: EHDAA:520 +xref: EMAPA:16548 +xref: FMA:45616 +xref: MA:0001526 +xref: NCIT:C34180 +xref: SCTID:361409009 +xref: TGMA:0001014 +xref: VHOG:0000285 +xref: Wikipedia:Foregut +xref: XAO:0000232 is_a: UBERON:0004921 ! subdivision of digestive tract [Term] id: UBERON:0001042 name: chordate pharynx +def: "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]." [http://www.feedexp.org] +comment: Consider generalizing to deuterostome pharynx +xref: AAO:0000967 +xref: BTO:0001049 +xref: CALOHA:TS-0785 +xref: EFO:0000836 +xref: EHDAA2:0001458 +xref: EHDAA:2947 +xref: EMAPA:16706 +xref: EV:0100065 +xref: FMA:46688 +xref: GAID:155 +xref: galen:Pharynx +xref: MA:0000432 +xref: MESH:D010614 +xref: NCIT:C12425 +xref: SCTID:181211006 +xref: TAO:0000056 +xref: VHOG:0000462 +xref: Wikipedia:Pharynx +xref: XAO:0003227 +xref: ZFA:0000056 is_a: UBERON:0006562 ! pharynx relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: distally_connected_to UBERON:0001043 {gci_filler="NCBITaxon:7742", gci_relation="BFO:0000050"} ! esophagus @@ -33381,41 +45296,216 @@ relationship: RO:0002551 UBERON:0008895 {gci_filler="NCBITaxon:89593", gci_relat [Term] id: UBERON:0001043 name: esophagus +def: "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993)." [http://www.rivm.nl/interspeciesinfo/inter/oesophagus/, Wikipedia:Esophagus] +xref: AAO:0000145 +xref: ANISEED:1235301 +xref: BTO:0000959 +xref: CALOHA:TS-0700 +xref: EFO:0000835 +xref: EHDAA2:0001285 +xref: EHDAA:2937 +xref: EMAPA:16833 +xref: EV:0100069 +xref: FMA:7131 +xref: GAID:291 +xref: galen:Esophagus +xref: MA:0000352 +xref: MAT:0000048 +xref: MESH:D004947 +xref: MIAA:0000048 +xref: NCIT:C12389 +xref: SCTID:181245004 +xref: TAO:0000204 +xref: VHOG:0000450 +xref: Wikipedia:Esophagus +xref: XAO:0000127 +xref: ZFA:0000204 is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0005178 ! thoracic cavity element is_a: UBERON:0013765 ! digestive system element relationship: BFO:0000050 UBERON:0004908 ! part of upper digestive tract relationship: proximally_connected_to UBERON:0001042 ! chordate pharynx relationship: RO:0002202 UBERON:0001041 ! foregut -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001045 +name: midgut +def: "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]." [GO:0007494, Wikipedia:Midgut] +xref: BILA:0000086 +xref: BTO:0000863 +xref: EFO:0001950 +xref: EHDAA2:0001185 +xref: EHDAA:983 +xref: EMAPA:16255 +xref: FMA:45617 +xref: MA:0001564 +xref: NCIT:C34210 +xref: SCTID:361410004 +xref: TGMA:0001036 +xref: VHOG:0000290 +xref: Wikipedia:Midgut +xref: XAO:0000103 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: proximally_connected_to UBERON:0001041 ! foregut + +[Term] +id: UBERON:0001046 +name: hindgut +def: "The caudalmost subdivision of a digestive tract." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0011052 +xref: BILA:0000087 +xref: BTO:0000510 +xref: EHDAA2:0000779 +xref: EHDAA:975 +xref: EMAPA:16715 +xref: FMA:45618 +xref: MA:0001527 +xref: NCIT:C34188 +xref: SCTID:362856002 +xref: TGMA:0001020 +xref: VHOG:0000459 +xref: Wikipedia:Hindgut +xref: XAO:0000104 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: proximally_connected_to UBERON:0001045 ! midgut +relationship: RO:0002202 UBERON:0003104 ! mesenchyme [Term] id: UBERON:0001048 name: primordium +def: "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]." [BTO:0001886, FB:DJS, FB:FBrf0089570, http://flybase.org/reports/FBrf0178740.html] +xref: AEO:0000171 +xref: BTO:0001886 +xref: EFO:0001652 +xref: EHDAA2:0003171 +xref: FMA:86589 +xref: MAT:0000482 +xref: NCIT:C34275 +xref: Wikipedia:Primordium +xref: XAO:0003043 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0000468 ! part of multicellular organism [Term] id: UBERON:0001049 name: neural tube +def: "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]." [Wikipedia:Neural_tube] +xref: AAO:0010617 +xref: BTO:0001057 +xref: CALOHA:TS-2371 +xref: DHBA:10154 +xref: EHDAA2:0001254 +xref: EHDAA:2869 +xref: EHDAA:908 +xref: EMAPA:16164 +xref: EMAPA:16757 +xref: FMA:293882 +xref: MAT:0000069 +xref: MIAA:0000069 +xref: NCIT:C34226 +xref: neuronames:1365 +xref: SCTID:362852000 +xref: TAO:0001135 +xref: VHOG:0000307 +xref: Wikipedia:Neural_tube +xref: XAO:0003204 +xref: ZFA:0001135 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0016879 ! future central nervous system relationship: RO:0002202 UBERON:0005068 ! neural rod +[Term] +id: UBERON:0001052 +name: rectum +def: "The terminal portion of the intestinal tube, terminating with the anus." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MP:0000492] +xref: AAO:0010401 +xref: BTO:0001158 +xref: CALOHA:TS-1180 +xref: EFO:0000848 +xref: EHDAA2:0001592 +xref: EHDAA:5836 +xref: EMAPA:17896 +xref: EV:0100081 +xref: FMA:14544 +xref: GAID:311 +xref: galen:Rectum +xref: MA:0000336 +xref: MAT:0000050 +xref: MESH:D012007 +xref: MIAA:0000050 +xref: NCIT:C12390 +xref: SCTID:181261002 +xref: VHOG:0001751 +xref: Wikipedia:Rectum +xref: XAO:0000238 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract +relationship: BFO:0000050 UBERON:0012361 ! part of internal anal region +relationship: BSPO:0001108 UBERON:0000059 ! large intestine +relationship: RO:0002150 UBERON:0001159 ! sigmoid colon +relationship: RO:0002433 UBERON:0000059 ! large intestine + [Term] id: UBERON:0001062 name: anatomical entity +def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [FMA:62955, http://orcid.org/0000-0001-9114-8737] +xref: AAO:0010841 +xref: AEO:0000000 +xref: BFO:0000004 +xref: BILA:0000000 +xref: BIRNLEX:6 +xref: CARO:0000000 +xref: EHDAA2:0002229 +xref: FMA:62955 +xref: HAO:0000000 +xref: MA:0000001 +xref: NCIT:C12219 +xref: TAO:0100000 +xref: TGMA:0001822 +xref: WBbt:0000100 +xref: XAO:0000000 +xref: ZFA:0100000 relationship: BFO:0000050 UBERON:0003942 {gci_relation="RO:0002216", gci_filler="GO:0050975"} ! part of somatosensory system relationship: BFO:0000050 UBERON:0003942 {gci_relation="RO:0002216", gci_filler="GO:0019233"} ! part of somatosensory system -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 + +[Term] +id: UBERON:0001064 +name: ventral pancreatic duct +def: "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla." [Wikipedia:Pancreatic_duct] +comment: EDITOR_NOTE in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue +xref: BTO:0002362 +xref: EHDAA2:0001396 +xref: EHDAA:6905 +xref: EMAPA:17510 +xref: FMA:16003 +xref: GAID:337 +xref: MA:0000126 +xref: MESH:D010183 +xref: NCIT:C12272 +xref: RETIRED_EHDAA2:0002177 +xref: SCTID:245385001 +xref: VHOG:0000256 +xref: Wikipedia:Pancreatic_duct +is_a: UBERON:0000025 ! tube +is_a: UBERON:0007329 ! pancreatic duct +relationship: channel_for UBERON:0001970 ! bile +relationship: channels_into UBERON:0004913 ! hepatopancreatic ampulla +relationship: RO:0002150 UBERON:0001174 ! common bile duct +relationship: RO:0002202 UBERON:0003924 ! ventral pancreatic bud [Term] id: UBERON:0001068 name: skin of back +def: "A zone of skin that is part of a back [Automatically generated definition]." [OBOL:automatic] +comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region +xref: EMAPA:36392 +xref: FMA:10462 +xref: FMA:22985 +xref: MA:0000498 +xref: SCTID:181492002 is_a: UBERON:0001085 ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum @@ -33424,36 +45514,100 @@ relationship: BFO:0000050 UBERON:0011270 ! part of dorsal trunk [Term] id: UBERON:0001070 name: external carotid artery +def: "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]." [MGI:anna] +xref: AAO:0010218 +xref: AAO:0010416 +xref: BTO:0004696 +xref: EFO:0001953 +xref: EHDAA2:0000461 +xref: EMAPA:18611 +xref: FMA:10635 +xref: GAID:480 +xref: MA:0001929 +xref: MESH:D002342 +xref: NCIT:C32551 +xref: SCTID:362044002 +xref: VHOG:0000265 +xref: Wikipedia:External_carotid_artery +xref: XAO:0000345 is_a: UBERON:0005396 ! carotid artery segment relationship: BFO:0000050 UBERON:0001530 ! part of common carotid artery plus branches relationship: RO:0002202 UBERON:0001530 ! common carotid artery plus branches relationship: RO:0002380 UBERON:0001530 ! common carotid artery plus branches -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001071 name: superficial cervical artery +def: "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery." [Wikipedia:Superficial_part_of_transverse_cervical_artery] +comment: The transverse cervical artery splits into two branches, a superficial one and a deep one[WP] +xref: FMA:10665 +xref: MA:0002052 +xref: NCIT:C53005 +xref: SCTID:161746006 +xref: Wikipedia:Superficial_part_of_transverse_cervical_artery is_a: UBERON:0012320 ! cervical artery intersection_of: UBERON:0012320 ! cervical artery intersection_of: BFO:0000050 UBERON:0035549 ! part of vasculature of integument relationship: BFO:0000050 UBERON:0035549 ! part of vasculature of integument relationship: RO:0002170 UBERON:0012324 ! transverse cervical artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001072 name: inferior vena cava +def: "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Inferior_vena_cava] +xref: AAO:0011083 +xref: BTO:0002682 +xref: EHDAA2:0000611 +xref: EMAPA:18416 +xref: FMA:10951 +xref: GAID:548 +xref: galen:InferiorVenaCava +xref: MA:0000480 +xref: MESH:D014682 +xref: NCIT:C12815 +xref: SCTID:181369003 +xref: VHOG:0001194 +xref: Wikipedia:Inferior_vena_cava +xref: XAO:0000388 is_a: UBERON:0004087 ! vena cava intersection_of: UBERON:0004087 ! vena cava intersection_of: RO:0002179 UBERON:0000154 ! posterior region of body relationship: channels_into UBERON:0002078 {gci_filler="NCBITaxon:40674", gci_relation="BFO:0000050"} ! right cardiac atrium relationship: RO:0002170 UBERON:0002078 ! right cardiac atrium relationship: RO:0002179 UBERON:0000154 ! posterior region of body -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001073 +name: ileocecal junction +def: "A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice." [http://www.medilexicon.com/medicaldictionary.php?t=46539] +xref: FMA:11338 +xref: MA:0000332 +xref: SCTID:264021000 +is_a: UBERON:8410024 ! intestinal junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0000059 ! large intestine +intersection_of: RO:0002176 UBERON:0002108 ! small intestine +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002176 UBERON:0000059 ! large intestine +relationship: RO:0002176 UBERON:0002108 ! small intestine [Term] id: UBERON:0001074 name: pericardial cavity +def: "A potential space between the visceral and parietal layers of the pericardium." [Wikipedia:Pericardium] +xref: BSA:0000091 +xref: EHDAA2:0001434 +xref: EMAPA:16131 +xref: EMAPA:16132 +xref: FMA:11350 +xref: galen:PericardialSpace +xref: MA:0000053 +xref: NCIT:C38662 +xref: SCTID:362027001 +xref: TAO:0002220 +xref: VHOG:0000556 +xref: Wikipedia:Pericardial_cavity +xref: ZFA:0001655 is_a: UBERON:0002323 ! coelemic cavity lumen is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity @@ -33467,6 +45621,14 @@ relationship: RO:0002572 UBERON:0002406 ! pericardial sac [Term] id: UBERON:0001081 name: endocardium of ventricle +def: "Endocardium that is part of the cardiac ventricle." [ZFIN:curator] +xref: EMAPA:32747 +xref: FMA:12148 +xref: MA:0000079 +xref: SCTID:192172004 +xref: TAO:0002247 +xref: VHOG:0000607 +xref: ZFA:0001615 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0002165 ! endocardium is_a: UBERON:0012275 ! meso-epithelium @@ -33478,6 +45640,10 @@ relationship: RO:0002433 UBERON:0002082 ! cardiac ventricle [Term] id: UBERON:0001082 name: epicardium of ventricle +def: "An epicardial layer that lines a cardiac ventricle." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:12150 +xref: TAO:0005058 +xref: ZFA:0005058 is_a: UBERON:0002348 ! epicardium intersection_of: UBERON:0002348 ! epicardium intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -33486,6 +45652,15 @@ relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle [Term] id: UBERON:0001083 name: myocardium of ventricle +def: "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer." [ZFIN:curator] +xref: EFO:0003088 +xref: EMAPA:32748 +xref: FMA:12151 +xref: MA:0000082 +xref: SCTID:192084000 +xref: TAO:0005061 +xref: VHOG:0000604 +xref: ZFA:0005061 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -33495,6 +45670,13 @@ relationship: RO:0002433 UBERON:0002082 ! cardiac ventricle [Term] id: UBERON:0001084 name: skin of head +def: "A zone of skin that is part of a head [Automatically generated definition]." [OBOL:automatic] +comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region +xref: FMA:12166 +xref: FMA:24756 +xref: MA:0000582 +xref: NCIT:C52757 +xref: SCTID:181484006 is_a: UBERON:0012180 ! head or neck skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -33503,6 +45685,13 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0001085 name: skin of trunk +def: "A zone of skin that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region +xref: FMA:12167 +xref: FMA:23093 +xref: MA:0000517 +xref: NCIT:C12295 +xref: SCTID:181489001 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -33511,6 +45700,13 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0001087 name: pleural fluid +def: "Transudate contained in the pleural cavity." [FMA:12273] +xref: BTO:0003080 +xref: FMA:12273 +xref: MA:0002532 +xref: MAT:0000500 +xref: ncithesaurus:Pleural_Fluid +xref: Wikipedia:Pleural_fluid is_a: UBERON:0036244 ! secretion of serous membrane intersection_of: UBERON:0007779 ! transudate intersection_of: RO:0001025 UBERON:0002402 ! pleural cavity @@ -33519,6 +45715,19 @@ relationship: RO:0001025 UBERON:0002402 ! pleural cavity [Term] id: UBERON:0001090 name: synovial fluid +def: "Joint fluid is a transudate of plasma that is actively secreted by synovial cells." [https://www.ncbi.nlm.nih.gov/books/NBK274/] +xref: BTO:0001339 +xref: CALOHA:TS-0996 +xref: ENVO:02000039 +xref: FMA:12277 +xref: GAID:265 +xref: galen:SynovialFluid +xref: MA:0002544 +xref: MESH:D013582 +xref: NCIT:C33718 +xref: TAO:0005154 +xref: Wikipedia:Synovial_fluid +xref: ZFA:0005154 is_a: UBERON:0007779 ! transudate is_a: UBERON:0007794 ! secretion of serous gland intersection_of: UBERON:0007779 ! transudate @@ -33527,9 +45736,74 @@ relationship: BFO:0000051 CHEBI:16336 ! has part relationship: RO:0001025 UBERON:0007617 ! synovial cavity of joint relationship: RO:0003001 CL:0000214 ! produced by synovial cell +[Term] +id: UBERON:0001092 +name: vertebral bone 1 +def: "The first vertebral bone in the vertebral column." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000709 +xref: EHDAA:10606 +xref: EMAPA:19431 +xref: FMA:12519 +xref: GAID:236 +xref: MA:0001421 +xref: MESH:D001270 +xref: NCIT:C32239 +xref: SCTID:181818007 +xref: TAO:0001167 +xref: Wikipedia:Atlas_(anatomy) +xref: ZFA:0001167 +is_a: UBERON:0002412 ! vertebra +relationship: BFO:0000050 UBERON:0006072 {gci_filler="NCBITaxon:32523", gci_relation="BFO:0000050"} ! part of cervical region of vertebral column +relationship: BSPO:0000096 UBERON:0001093 ! vertebral bone 2 + +[Term] +id: UBERON:0001093 +name: vertebral bone 2 +def: "The second vertebral bone in the vertebral column." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA:10608 +xref: EMAPA:19432 +xref: FMA:12520 +xref: GAID:237 +xref: MA:0001422 +xref: MESH:D001368 +xref: NCIT:C32240 +xref: SCTID:181819004 +xref: TAO:0001168 +xref: Wikipedia:Axis_(anatomy) +xref: ZFA:0001168 +is_a: UBERON:0002412 ! vertebra +relationship: anteriorly_connected_to UBERON:0001092 ! vertebral bone 1 +relationship: BFO:0000050 UBERON:0006072 {gci_filler="NCBITaxon:32523", gci_relation="BFO:0000050"} ! part of cervical region of vertebral column + +[Term] +id: UBERON:0001095 +name: caudal vertebra +def: "Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx)." [http://orcid.org/0000-0002-6601-2165] +comment: Taxon notes In zebrafish, Vertebra bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae +xref: EMAPA:18374 +xref: FMA:12527 +xref: galen:CoccygealVertebra +xref: MA:0000310 +xref: MA:0001420 +xref: NCIT:C32334 +xref: SCTID:361774004 +xref: TAO:0000326 +xref: Wikipedia:Caudal_vertebra +xref: XAO:0003079 +xref: ZFA:0000326 +is_a: UBERON:0002412 ! vertebra +is_a: UBERON:0004247 ! bone of dorsum +is_a: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002481 ! bone tissue + [Term] id: UBERON:0001096 name: wall of esophagus +def: "An anatomical wall that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35326 +xref: FMA:12611 +xref: MA:0002691 is_a: UBERON:0000328 ! gut wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -33538,15 +45812,127 @@ relationship: BFO:0000050 UBERON:0001043 ! part of esophagus [Term] id: UBERON:0001103 name: diaphragm +def: "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control." [MP:0002279] +xref: BTO:0000341 +xref: CALOHA:TS-0198 +xref: EFO:0000937 +xref: EHDAA2:0003495 +xref: EMAPA:17701 +xref: EV:0100376 +xref: FMA:13295 +xref: GAID:158 +xref: MA:0001904 +xref: MAT:0000502 +xref: MESH:D003964 +xref: NCIT:C12702 +xref: SCTID:181614006 +xref: VHOG:0000713 +xref: Wikipedia:Thoracid_diaphragm is_a: UBERON:0003830 ! thoracic segment muscle is_a: UBERON:0003831 ! respiratory system muscle relationship: RO:0002005 UBERON:0001884 ! phrenic nerve relationship: RO:0002160 NCBITaxon:40674 ! Mammalia relationship: RO:0002495 UBERON:0010084 ! future diaphragm +[Term] +id: UBERON:0001113 +name: lobe of liver +def: "Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe." [Wikipedia:Liver#Lobes] +xref: EMAPA:18306 +xref: FMA:13361 +xref: MA:0000360 +xref: NCIT:C49579 +xref: SCTID:245378000 +xref: Wikipedia:Liver#Lobes +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0009912 ! anatomical lobe +relationship: BFO:0000050 UBERON:0002107 ! part of liver + +[Term] +id: UBERON:0001114 +name: right lobe of liver +def: "The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]." [Wikipedia:Right_lobe_of_liver] +xref: EHDAA2:0001008 +xref: EHDAA:4001 +xref: EMAPA:18311 +xref: FMA:13362 +xref: MA:0000363 +xref: NCIT:C33481 +xref: SCTID:362182008 +xref: TAO:0005173 +xref: VHOG:0001424 +xref: Wikipedia:Right_lobe_of_liver +xref: ZFA:0005173 +is_a: UBERON:0001113 ! lobe of liver + +[Term] +id: UBERON:0001115 +name: left lobe of liver +def: "The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]." [Wikipedia:Left_lobe_of_liver] +xref: EHDAA2:0001000 +xref: EHDAA:3995 +xref: EMAPA:18307 +xref: FMA:13363 +xref: MA:0000361 +xref: NCIT:C32965 +xref: SCTID:362183003 +xref: TAO:0005172 +xref: VHOG:0001423 +xref: Wikipedia:Left_lobe_of_liver +xref: ZFA:0005172 +is_a: UBERON:0001113 ! lobe of liver + +[Term] +id: UBERON:0001130 +name: vertebral column +def: "Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]." [https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/tracker/?func=detail&aid=3530322&group_id=76834&atid=2257941, VSAO:0000185] +xref: AAO:0000699 +xref: AAO:0000734 +xref: BTO:0000818 +xref: EFO:0001369 +xref: EHDA:10119 +xref: EMAPA:35919 +xref: FMA:13478 +xref: GAID:106 +xref: galen:SpinalColumn +xref: MA:0002416 +xref: MESH:D013131 +xref: NCIT:C12998 +xref: NCIT:C33588 +xref: NIF_Subcellular:sao1145756102 +xref: SCTID:44300000 +xref: TAO:0001559 +xref: VHOG:0001142 +xref: VSAO:0000185 +xref: Wikipedia:Vertebral_column +xref: XAO:0003074 +xref: ZFA:0001559 +is_a: UBERON:0000075 ! subdivision of skeletal system +intersection_of: UBERON:0000075 ! subdivision of skeletal system +intersection_of: RO:0002473 UBERON:0010913 ! vertebral element +relationship: BFO:0000050 UBERON:0011138 ! part of postcranial axial skeletal system +relationship: protects UBERON:0002240 ! spinal cord +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002473 UBERON:0010913 ! vertebral element + [Term] id: UBERON:0001133 name: cardiac muscle tissue +def: "Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]." [ZFA:0005280] +xref: AAO:0010245 +xref: AEO:0000142 +xref: BILA:0000134 +xref: BTO:0000199 +xref: CALOHA:TS-0440 +xref: EHDAA2:0003142 +xref: EMAPA:32688 +xref: FMA:14068 +xref: galen:CardiacMuscle +xref: galen:CardiacMuscleTissue +xref: ncithesaurus:Heart_Muscle +xref: TAO:0005280 +xref: Wikipedia:Cardiac_muscle +xref: ZFA:0005280 is_a: UBERON:8600006 ! visceral striated muscle tissue intersection_of: UBERON:0002036 ! striated muscle tissue intersection_of: BFO:0000051 CL:0000746 ! has part cardiac muscle cell @@ -33558,6 +45944,13 @@ relationship: RO:0002473 CL:0000746 ! cardiac muscle cell [Term] id: UBERON:0001134 name: skeletal muscle tissue +def: "Muscle tissue that consists primarily of skeletal muscle fibers." [https://github.com/obophenotype/uberon/issues/324] +xref: EMAPA:32716 +xref: FMA:14069 +xref: MA:0002439 +xref: NCIT:C13050 +xref: SCTID:426215008 +xref: Wikipedia:Skeletal_striated_muscle is_a: UBERON:0002036 ! striated muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: RO:0002473 CL:0008002 ! skeletal muscle fiber @@ -33568,6 +45961,30 @@ relationship: RO:0002473 CL:0008002 ! skeletal muscle fiber [Term] id: UBERON:0001135 name: smooth muscle tissue +def: "Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]." [GO:0006939, Wikipedia:Smooth_muscle_tissue] +xref: AAO:0010244 +xref: AEO:0000141 +xref: BTO:0001260 +xref: CALOHA:TS-0943 +xref: EFO:0000889 +xref: EHDAA2:0003141 +xref: EMAPA:32717 +xref: EV:0100378 +xref: FMA:14070 +xref: GAID:167 +xref: galen:SmoothMuscle +xref: galen:SmoothMuscleTissue +xref: MA:0000166 +xref: MAT:0000303 +xref: MESH:D009130 +xref: MIAA:0000303 +xref: NCIT:C12437 +xref: TAO:0005274 +xref: VHOG:0001246 +xref: WBbt:0005781 +xref: Wikipedia:Smooth_muscle_tissue +xref: XAO:0000175 +xref: ZFA:0005274 is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: BFO:0000051 CL:0000192 ! has part smooth muscle cell @@ -33579,6 +45996,23 @@ relationship: RO:0002473 CL:0000192 ! smooth muscle cell [Term] id: UBERON:0001136 name: mesothelium +def: "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri)." [FMA:14074, Wikipedia:Mesothelium] +xref: AEO:0000111 +xref: BTO:0002422 +xref: CALOHA:TS-1183 +xref: EHDAA2_RETIRED:0003111 +xref: EHDAA:2331 +xref: EHDAA:2349 +xref: EHDAA:295 +xref: EHDAA:6073 +xref: EHDAA:640 +xref: EHDAA:646 +xref: EMAPA:32856 +xref: FMA:14074 +xref: MA:0000565 +xref: NCIT:C33105 +xref: SCTID:361918002 +xref: Wikipedia:Mesothelium is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000487 ! simple squamous epithelium @@ -33590,12 +46024,78 @@ relationship: RO:0002473 CL:0000077 ! mesothelial cell [Term] id: UBERON:0001137 name: dorsum +def: "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.." [BSPO:0000063, UBERONREF:0000006, Wikipedia:Dorsum_(anatomy)] +xref: BTO:0001713 +xref: CALOHA:TS-2223 +xref: EFO:0001405 +xref: FMA:14181 +xref: GAID:30 +xref: galen:Back +xref: MESH:D001415 +xref: NCIT:C13062 +xref: SCTID:123961009 +xref: Wikipedia:Dorsum_(anatomy) is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002160 NCBITaxon:33213 ! Bilateria +[Term] +id: UBERON:0001138 +name: superior mesenteric vein +def: "In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." [Wikipedia:Superior_mesenteric_vein] +xref: BTO:0002783 +xref: EHDAA2:0001951 +xref: EHDAA:5414 +xref: EMAPA:18643 +xref: FMA:14332 +xref: MA:0002179 +xref: NCIT:C33687 +xref: SCTID:278031001 +xref: VHOG:0000552 +xref: Wikipedia:Superior_mesenteric_vein +is_a: UBERON:0005617 ! mesenteric vein +intersection_of: UBERON:0005617 ! mesenteric vein +intersection_of: RO:0002179 UBERON:0002108 ! small intestine +relationship: BFO:0000050 UBERON:0005806 ! part of portal system +relationship: RO:0002170 UBERON:0001639 ! hepatic portal vein +relationship: RO:0002179 UBERON:0002108 ! small intestine +relationship: RO:0002202 UBERON:0005487 ! vitelline vein + +[Term] +id: UBERON:0001143 +name: hepatic vein +def: "Vein that carries blood away from the liver[ZFA]." [https://sourceforge.net/tracker/?func=detail&aid=3565355&group_id=76834&atid=1205376, Wikipedia:Hepatic_vein, ZFA:0000670] +xref: AAO:0010216 +xref: EMAPA:19221 +xref: FMA:14337 +xref: GAID:534 +xref: galen:HepaticVein +xref: MA:0003015 +xref: MESH:D006503 +xref: NCIT:C32736 +xref: SCTID:278191001 +xref: TAO:0000670 +xref: Wikipedia:Hepatic_vein +xref: XAO:0000387 +xref: ZFA:0000670 +is_a: UBERON:0013126 ! vein of abdomen +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001638 ! vein +intersection_of: RO:0002179 UBERON:0002107 ! liver +disjoint_from: UBERON:0001639 ! hepatic portal vein +relationship: BFO:0000050 UBERON:0006877 ! part of vasculature of liver +relationship: RO:0002179 UBERON:0002107 ! liver +relationship: RO:0002376 UBERON:0001072 ! inferior vena cava + [Term] id: UBERON:0001145 name: ovarian vein +def: "A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries." [Wikipedia:Ovarian_vein] +xref: EMAPA:18644 +xref: FMA:14346 +xref: MA:0002186 +xref: NCIT:C53058 +xref: SCTID:278193003 +xref: Wikipedia:Ovarian_vein is_a: UBERON:0001638 ! vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001638 ! vein @@ -33603,18 +46103,342 @@ intersection_of: RO:0002179 UBERON:0000992 ! ovary relationship: BSPO:0000126 UBERON:0000468 ! multicellular organism relationship: RO:0002179 UBERON:0000992 ! ovary +[Term] +id: UBERON:0001152 +name: cystic duct +def: "The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct." [ISBN:0-683-40008-8, MP:0009493] +xref: EHDAA2:0000333 +xref: EHDAA:3045 +xref: EMAPA:16841 +xref: FMA:14539 +xref: GAID:290 +xref: galen:CysticDuct +xref: MA:0000355 +xref: MESH:D003549 +xref: NCIT:C32421 +xref: SCTID:245398005 +xref: TAO:0005166 +xref: VHOG:0000213 +xref: Wikipedia:Cystic_duct +xref: ZFA:0005166 +is_a: UBERON:0003703 ! extrahepatic bile duct +intersection_of: UBERON:0000058 ! duct +intersection_of: RO:0002150 UBERON:0001174 ! common bile duct +intersection_of: RO:0002150 UBERON:0002110 ! gallbladder +disjoint_from: UBERON:0005171 ! hepatic duct +relationship: channels_into UBERON:0001174 ! common bile duct +relationship: RO:0002150 UBERON:0001174 ! common bile duct +relationship: RO:0002150 UBERON:0002110 ! gallbladder +relationship: RO:0002202 UBERON:0005604 ! extrahepatic part of hepatic duct + +[Term] +id: UBERON:0001155 +name: colon +def: "A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal." [http://orcid.org/0000-0002-2825-0621, http://orcid.org/0000-0002-6601-2165, Wikipedia:Colon_(anatomy), ZFIN:curator] +xref: AAO:0010400 +xref: BTO:0000269 +xref: CALOHA:TS-0158 +xref: EFO:0000361 +xref: EMAPA:18939 +xref: EV:0100079 +xref: FMA:14543 +xref: GAID:309 +xref: galen:Colon +xref: MA:0000335 +xref: MAP:0000001 +xref: MAT:0000526 +xref: MESH:D003106 +xref: NCIT:C12382 +xref: SCTID:302508007 +xref: TAO:0000706 +xref: VHOG:0000648 +xref: Wikipedia:Colon_(anatomy) +xref: XAO:0000243 +xref: ZFA:0000706 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002433 UBERON:0000059 ! large intestine + +[Term] +id: UBERON:0001159 +name: sigmoid colon +def: "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity." [Wikipedia:Sigmoid_colon] +xref: BTO:0000645 +xref: CALOHA:TS-2044 +xref: EFO:0000846 +xref: EMAPA:36391 +xref: FMA:14548 +xref: galen:SigmoidColon +xref: MAT:0000314 +xref: MESH:D012809 +xref: MIAA:0000314 +xref: NCIT:C12384 +xref: NCIT:C33550 +xref: SCTID:362166007 +xref: Wikipedia:Sigmoid_colon +is_a: UBERON:0000168 ! proximal-distal subdivision of colon +relationship: RO:0002150 UBERON:0001052 ! rectum +relationship: RO:0002202 UBERON:0001046 ! hindgut + +[Term] +id: UBERON:0001161 +name: body of stomach +def: "The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]." [GO:0014845, Wikipedia:Body_of_stomach] +xref: BTO:0000505 +xref: EMAPA:35810 +xref: FMA:14560 +xref: galen:GastricCorpus +xref: MA:0002559 +xref: NCIT:C12258 +xref: SCTID:362140009 +xref: Wikipedia:Body_of_stomach +is_a: UBERON:0009870 ! zone of stomach + +[Term] +id: UBERON:0001165 +name: pyloric antrum +def: "The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells." [ISBN:0-683-40008-8, MP:0010790] +xref: BTO:0001732 +xref: EFO:0002555 +xref: EMAPA:17891 +xref: FMA:14579 +xref: GAID:332 +xref: galen:PyloricAntrum +xref: MA:0001624 +xref: MESH:D011706 +xref: NCIT:C12259 +xref: SCTID:362142001 +xref: Wikipedia:Pyloric_antrum +is_a: UBERON:0009870 ! zone of stomach +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000051 CL:0000502 ! has part type D enteroendocrine cell +relationship: BFO:0000051 CL:0000508 ! has part type G enteroendocrine cell +relationship: RO:0002150 UBERON:0001161 ! body of stomach +relationship: RO:0002433 UBERON:0001166 ! pylorus + +[Term] +id: UBERON:0001166 +name: pylorus +def: "The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum." [MGI:csmith, MP:0010785] +xref: BTO:0001146 +xref: EHDAA2:0001580 +xref: EHDAA:4860 +xref: EMAPA:17631 +xref: FMA:14581 +xref: GAID:333 +xref: galen:Pylorus +xref: MA:0002560 +xref: MESH:D011708 +xref: NCIT:C12260 +xref: SCTID:362143006 +xref: VHOG:0000420 +xref: Wikipedia:Pylorus +is_a: UBERON:0009870 ! zone of stomach +intersection_of: UBERON:0009870 ! zone of stomach +intersection_of: BFO:0000051 UBERON:0001165 ! has part pyloric antrum +intersection_of: BFO:0000051 UBERON:0008858 ! has part pyloric canal +intersection_of: BFO:0000051 UBERON:0008861 ! has part pyloric gastric gland +relationship: BFO:0000051 UBERON:0001165 ! has part pyloric antrum +relationship: BFO:0000051 UBERON:0008858 ! has part pyloric canal +relationship: BFO:0000051 UBERON:0008861 ! has part pyloric gastric gland +relationship: RO:0002433 UBERON:0000945 ! stomach + [Term] id: UBERON:0001167 name: wall of stomach +def: "The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between." [MGI:csmith, MP:0010783] +xref: EMAPA:35826 +xref: FMA:14582 +xref: galen:WallOfStomach +xref: MA:0002692 +xref: SCTID:279995000 is_a: UBERON:0000328 ! gut wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0000945 ! part of stomach relationship: RO:0002433 UBERON:0000945 ! stomach +[Term] +id: UBERON:0001168 +name: wall of small intestine +def: "An anatomical wall that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35785 +xref: FMA:14615 +xref: MA:0002696 +xref: NCIT:C33573 +is_a: UBERON:0001262 ! wall of intestine +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: UBERON:0001169 +name: wall of large intestine +def: "An anatomical wall that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35470 +xref: FMA:14619 +xref: MA:0002695 +is_a: UBERON:0001262 ! wall of intestine +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine + +[Term] +id: UBERON:0001170 +name: mesentery of small intestine +def: "The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]." [Wikipedia:Mesentery#Mesentery_.28proper.29] +xref: FMA:14643 +xref: MA:0001555 +xref: SCTID:245456008 +xref: Wikipedia:Mesentery#Mesentery_.28proper.29 +is_a: UBERON:0001206 ! serosa of small intestine +is_a: UBERON:0004854 ! gastrointestinal system mesentery +is_a: UBERON:0007826 ! peritoneal mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: UBERON:0001171 +name: portal lobule +def: "The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." [MP:0008992] +xref: FMA:14653 +xref: MA:0002498 +xref: NCIT:C33341 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0009911 ! lobule +relationship: BFO:0000050 UBERON:0001280 ! part of liver parenchyma +relationship: RO:0002433 UBERON:0001280 ! liver parenchyma + +[Term] +id: UBERON:0001172 +name: hepatic acinus +def: "The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids." [http://orcid.org/0000-0002-6601-2165, http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_acinus.html] +xref: EMAPA:35497 +xref: FMA:14654 +xref: MA:0002496 +xref: NCIT:C32992 +xref: SCTID:272214009 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0011858 ! acinus of exocrine gland +relationship: BFO:0000050 UBERON:0001280 ! part of liver parenchyma +relationship: RO:0002131 UBERON:0001171 ! overlaps portal lobule +relationship: RO:0002131 UBERON:0004647 ! overlaps liver lobule + +[Term] +id: UBERON:0001173 +name: biliary tree +def: "A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder." [DOI:10.1002/ar.20664] +comment: The path in many species is as follows: Bile canaliculi -> Canals of Hering (intralobar bile duct) -> interlobular bile ducts -> intrahepatic bile ducts -> left and right hepatic ducts merge to form -> common hepatic duct *exits liver* and joins -> cystic duct (from gall bladder) forming -> common bile duct -> joins with pancreatic duct -> forming ampulla of Vater -> enters duodenum [WP] +xref: AAO:0011020 +xref: EMAPA:35172 +xref: FMA:14665 +xref: SCTID:181267003 +xref: Wikipedia:Biliary_tract +xref: XAO:0000455 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0000062 ! organ +intersection_of: BFO:0000050 UBERON:0002294 ! part of biliary system +intersection_of: RO:0002473 UBERON:0002394 ! bile duct +relationship: BFO:0000050 UBERON:0002294 ! part of biliary system +relationship: BFO:0000051 UBERON:0001246 ! has part interlobular bile duct +relationship: BFO:0000051 UBERON:0001282 ! has part intralobular bile duct +relationship: BFO:0000051 UBERON:0003703 ! has part extrahepatic bile duct +relationship: RO:0002202 UBERON:0004912 ! biliary bud +relationship: RO:0002433 UBERON:0002423 ! hepatobiliary system +relationship: RO:0002473 UBERON:0002394 ! bile duct + +[Term] +id: UBERON:0001174 +name: common bile duct +def: "The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct." [MGI:csmith, MP:0009495] +xref: EHDAA2:0000303 +xref: EHDAA:3981 +xref: EMAPA:17201 +xref: FMA:14667 +xref: GAID:282 +xref: galen:CommonBileDuct +xref: MA:0001631 +xref: MESH:D003135 +xref: NCIT:C12698 +xref: SCTID:362199009 +xref: TAO:0005165 +xref: VHOG:0000214 +xref: Wikipedia:Common_bile_duct +xref: ZFA:0005165 +is_a: UBERON:0003703 ! extrahepatic bile duct +relationship: channels_into UBERON:0001064 ! ventral pancreatic duct +relationship: RO:0002150 UBERON:0001152 ! cystic duct +relationship: RO:0002150 UBERON:0001175 ! common hepatic duct + +[Term] +id: UBERON:0001175 +name: common hepatic duct +def: "Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]." [Wikipedia:Common_hepatic_duct, ZFIN:curator] +xref: EMAPA:19101 +xref: FMA:14668 +xref: GAID:286 +xref: MA:0002660 +xref: MESH:D006500 +xref: NCIT:C32356 +xref: SCTID:245403006 +xref: VHOG:0000220 +xref: Wikipedia:Common_hepatic_duct +is_a: UBERON:0003703 ! extrahepatic bile duct +relationship: BFO:0000050 UBERON:0005604 ! part of extrahepatic part of hepatic duct +relationship: channels_into UBERON:0001174 ! common bile duct +relationship: RO:0002150 UBERON:0001176 ! right hepatic duct +relationship: RO:0002150 UBERON:0001177 ! left hepatic duct +relationship: RO:0002495 UBERON:0010081 ! future common hepatic duct + +[Term] +id: UBERON:0001176 +name: right hepatic duct +def: "The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct." [http://www.medterms.com/script/main/art.asp?articlekey=26034] +xref: EHDAA2:0001727 +xref: EHDAA:3992 +xref: EMAPA:32797 +xref: FMA:14669 +xref: MA:0001639 +xref: NCIT:C33476 +xref: SCTID:245401008 +xref: VHOG:0000217 +is_a: UBERON:0003703 ! extrahepatic bile duct +intersection_of: UBERON:0003703 ! extrahepatic bile duct +intersection_of: RO:0002150 UBERON:0001114 ! right lobe of liver +relationship: BFO:0000050 UBERON:0005171 ! part of hepatic duct +relationship: RO:0002150 UBERON:0001114 ! right lobe of liver + +[Term] +id: UBERON:0001177 +name: left hepatic duct +def: "The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct." [http://www.medterms.com/script/main/art.asp?articlekey=26035] +xref: EHDAA2:0000941 +xref: EHDAA:3990 +xref: EMAPA:32795 +xref: FMA:14670 +xref: MA:0001638 +xref: NCIT:C32960 +xref: SCTID:245400009 +xref: VHOG:0000218 +is_a: UBERON:0003703 ! extrahepatic bile duct +intersection_of: UBERON:0003703 ! extrahepatic bile duct +intersection_of: RO:0002150 UBERON:0001115 ! left lobe of liver +relationship: BFO:0000050 UBERON:0005171 ! part of hepatic duct +relationship: RO:0002150 UBERON:0001115 ! left lobe of liver + [Term] id: UBERON:0001178 name: visceral peritoneum +def: "The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Peritoneum#Types] +xref: EMAPA:16592 +xref: FMA:14703 +xref: SCTID:362702003 +xref: TAO:0005132 +xref: VHOG:0001528 +xref: Wikipedia:Visceral_peritoneum +xref: ZFA:0005132 is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0022350 ! visceral serous membrane intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum @@ -33623,6 +46447,18 @@ relationship: BFO:0000050 UBERON:0002358 ! part of peritoneum [Term] id: UBERON:0001179 name: peritoneal cavity +def: "Anatomical cavity bounded by visceral and parietal peritoneum." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/86, Wikipedia:Peritoneal_cavity] +xref: BTO:0001782 +xref: EHDAA2:0001446 +xref: EMAPA:16138 +xref: FMA:14704 +xref: GAID:24 +xref: MA:0000054 +xref: MESH:D010529 +xref: NCIT:C12769 +xref: SCTID:181616008 +xref: VHOG:0000852 +xref: Wikipedia:Peritoneal_cavity is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002220 UBERON:0001178 ! adjacent to visceral peritoneum @@ -33637,16 +46473,75 @@ relationship: RO:0002572 UBERON:0035820 ! peritoneal sac [Term] id: UBERON:0001190 name: ovarian artery +def: "An artery that supplies an ovary." [OBOL:automatic] +xref: EMAPA:18620 +xref: FMA:14761 +xref: MA:0002012 +xref: NCIT:C33242 +xref: SCTID:244280002 +xref: Wikipedia:Ovarian_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0000992 ! ovary relationship: RO:0002170 UBERON:0001516 ! abdominal aorta relationship: RO:0002178 UBERON:0000992 ! ovary -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001193 +name: hepatic artery +def: "An artery that supplies the liver." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Hepatic_artery_proper] +xref: BTO:0004307 +xref: EMAPA:17859 +xref: FMA:14769 +xref: GAID:496 +xref: galen:HepaticArtery +xref: MA:0001963 +xref: MESH:D006499 +xref: NCIT:C32729 +xref: SCTID:76015000 +xref: TAO:0005161 +xref: ZFA:0005161 +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0002107 ! liver +relationship: RO:0002178 UBERON:0002107 ! liver + +[Term] +id: UBERON:0001194 +name: splenic artery +def: "An artery that supplies the spleen." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:19216 +xref: FMA:14773 +xref: GAID:510 +xref: galen:SplenicArtery +xref: MA:0001991 +xref: MA:0003177 +xref: MESH:D013157 +xref: NCIT:C33597 +xref: SCTID:244266009 +xref: Wikipedia:Splenic_artery +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0002106 ! spleen +disjoint_from: UBERON:0001640 ! celiac artery +relationship: RO:0002178 UBERON:0002106 ! spleen +relationship: RO:0002252 UBERON:0001640 ! celiac artery [Term] id: UBERON:0001199 name: mucosa of stomach +def: "The mucosal layer that lines the stomach." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0001308 +xref: CALOHA:TS-0404 +xref: EMAPA:35817 +xref: FMA:14907 +xref: GAID:321 +xref: galen:GastricMucosa +xref: MA:0002683 +xref: MESH:D005753 +xref: NCIT:C32656 +xref: SCTID:362131005 +xref: Wikipedia:Gastric_mucosa is_a: UBERON:0004786 ! gastrointestinal system mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach @@ -33657,6 +46552,13 @@ relationship: RO:0002433 UBERON:0001167 ! wall of stomach [Term] id: UBERON:0001200 name: submucosa of stomach +def: "The fibrous connective tissue layer beneath the stomach mucosa." [MGI:csmith, MP:0010794] +xref: BTO:0002110 +xref: EMAPA:35825 +xref: FMA:14908 +xref: MA:0002685 +xref: NCIT:C32663 +xref: SCTID:52459002 is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach @@ -33666,15 +46568,356 @@ relationship: RO:0002433 UBERON:0001167 ! wall of stomach [Term] id: UBERON:0001201 name: serosa of stomach +def: "The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum." [MGI:csmith, MP:0010793] +xref: EMAPA:35822 +xref: FMA:14914 +xref: MA:0001626 +xref: NCIT:C32662 +xref: SCTID:1353004 is_a: UBERON:0004782 ! gastrointestinal system serosa intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0001167 ! part of wall of stomach relationship: BFO:0000050 UBERON:0001167 ! part of wall of stomach relationship: RO:0002433 UBERON:0001167 ! wall of stomach +[Term] +id: UBERON:0001202 +name: pyloric sphincter +def: "A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0011093 +xref: EMAPA:19251 +xref: FMA:14916 +xref: MA:0002952 +xref: NCIT:C33433 +xref: SCTID:268073008 +xref: VHOG:0001466 +xref: XAO:0000457 +is_a: UBERON:0011185 ! gastrointestinal sphincter +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: RO:0002150 UBERON:0008858 ! pyloric canal +relationship: RO:0002220 UBERON:0002114 ! adjacent to duodenum +relationship: RO:0002433 UBERON:0001166 ! pylorus + +[Term] +id: UBERON:0001204 +name: mucosa of small intestine +def: "A mucosa that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001259 +xref: CALOHA:TS-0941 +xref: EMAPA:35780 +xref: FMA:14933 +xref: MA:0002686 +xref: NCIT:C33568 +xref: SCTID:362144000 +is_a: UBERON:0001242 ! intestinal mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine +relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa + +[Term] +id: UBERON:0001205 +name: submucosa of small intestine +def: "Submucosal tissue in the small intestines." [Wikipedia:Small_intestinal_submucosa] +xref: BTO:0002112 +xref: FMA:14934 +xref: MA:0001562 +xref: NCIT:C33572 +xref: SCTID:691000 +xref: Wikipedia:Small_intestinal_submucosa +is_a: UBERON:0009566 ! intestinal submucosa +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine + +[Term] +id: UBERON:0001206 +name: serosa of small intestine +def: "A serous membrane that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14938 +xref: MA:0001558 +xref: SCTID:8266009 +is_a: UBERON:0001243 ! serosa of intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine +relationship: BFO:0000050 UBERON:0001243 ! part of serosa of intestine + +[Term] +id: UBERON:0001207 +name: mucosa of large intestine +def: "A mucosa that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: CALOHA:TS-2106 +xref: EMAPA:35467 +xref: FMA:14969 +xref: MA:0002688 +xref: NCIT:C32926 +is_a: UBERON:0001242 ! intestinal mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine +relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa + +[Term] +id: UBERON:0001208 +name: submucosa of large intestine +def: "A submucosa that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0002111 +xref: FMA:14970 +xref: MA:0002690 +xref: NCIT:C32930 +is_a: UBERON:0009566 ! intestinal submucosa +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine + +[Term] +id: UBERON:0001209 +name: serosa of large intestine +def: "A serous membrane that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14975 +xref: MA:0001546 +xref: NCIT:C32929 +is_a: UBERON:0001243 ! serosa of intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine +relationship: BFO:0000050 UBERON:0001243 ! part of serosa of intestine + +[Term] +id: UBERON:0001212 +name: duodenal gland +def: "A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]." [Wikipedia:Brunner's_glands] +xref: BTO:0002376 +xref: EMAPA:36522 +xref: FMA:15060 +xref: GAID:314 +xref: MA:0001551 +xref: MESH:D002011 +xref: NCIT:C13010 +xref: SCTID:41298001 +xref: Wikipedia:Brunner's_glands +is_a: UBERON:0003408 ! gland of digestive tract +is_a: UBERON:0011148 ! submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: RO:0001025 UBERON:0003332 ! submucosa of duodenum +relationship: RO:0002160 NCBITaxon:40674 ! Mammalia + +[Term] +id: UBERON:0001213 +name: intestinal villus +def: "The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold." [MGI:csmith, MGI:rbabiuk, MP:0008108] +xref: BTO:0003121 +xref: EMAPA:35784 +xref: FMA:15072 +xref: MA:0001563 +xref: NCIT:C33874 +xref: SCTID:23230007 +xref: TAO:0005125 +xref: Wikipedia:Intestinal_villus +xref: ZFA:0005125 +is_a: UBERON:0004923 ! organ component layer +relationship: BFO:0000050 UBERON:0001277 ! part of intestinal epithelium +relationship: BFO:0000051 UBERON:0001981 ! has part blood vessel +relationship: BFO:0000051 UBERON:0012425 ! has part striated border microvillus layer + +[Term] +id: UBERON:0001215 +name: inferior mesenteric vein +def: "A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]." [Wikipedia:Inferior_mesenteric_vein] +xref: BTO:0002782 +xref: EHDAA2:0000819 +xref: EHDAA:8712 +xref: EMAPA:18642 +xref: FMA:15391 +xref: MA:0002178 +xref: NCIT:C32782 +xref: SCTID:281055007 +xref: VHOG:0001118 +xref: Wikipedia:Inferior_mesenteric_vein +is_a: UBERON:0005617 ! mesenteric vein +intersection_of: UBERON:0005617 ! mesenteric vein +intersection_of: RO:0002179 UBERON:0000059 ! large intestine +relationship: RO:0002179 UBERON:0000059 ! large intestine +relationship: RO:0002376 UBERON:0003713 ! splenic vein + +[Term] +id: UBERON:0001238 +name: lamina propria of small intestine +def: "Lamina propria that is part_of the small intestine." [GOC:Obol] +xref: EMAPA:35779 +xref: FMA:15651 +xref: MA:0001554 +xref: NCIT:C49297 +xref: SCTID:63588008 +is_a: UBERON:0004780 ! gastrointestinal system lamina propria +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001204 ! part of mucosa of small intestine + +[Term] +id: UBERON:0001242 +name: intestinal mucosa +def: "Mucosal layer that lines the intestine." [UBERON:cjm] +xref: BTO:0000642 +xref: EMAPA:35440 +xref: FMA:15695 +xref: GAID:296 +xref: MA:0001537 +xref: MESH:D007413 +xref: NCIT:C49241 +xref: SCTID:362080002 +is_a: UBERON:0004786 ! gastrointestinal system mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine + +[Term] +id: UBERON:0001243 +name: serosa of intestine +def: "A serous membrane that is part of a wall of intestine [Automatically generated definition]." [OBOL:automatic] +xref: FMA:15701 +xref: MA:0001538 +is_a: UBERON:0004782 ! gastrointestinal system serosa +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine + +[Term] +id: UBERON:0001245 +name: anus +def: "Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts." [Wikipedia:Anus, ZFIN:curator] +xref: BTO:0001680 +xref: CALOHA:TS-2005 +xref: EV:0100082 +xref: FMA:15711 +xref: GAID:312 +xref: galen:Anus +xref: MA:0000331 +xref: NCIT:C43362 +xref: SCTID:181262009 +xref: TADS:0000066 +xref: TGMA:0001279 +xref: WBbt:0005364 +xref: Wikipedia:Anus +is_a: UBERON:0000161 ! orifice +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000161 ! orifice +intersection_of: BSPO:0001108 UBERON:0001555 ! digestive tract +relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract +relationship: BSPO:0001108 UBERON:0001555 ! digestive tract +relationship: RO:0002202 UBERON:0000931 ! proctodeum + +[Term] +id: UBERON:0001246 +name: interlobular bile duct +def: "The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad." [MP:0009500] +xref: FMA:15767 +xref: MA:0002668 +xref: NCIT:C32827 +xref: SCTID:83488001 +xref: Wikipedia:Interlobular_bile_ducts +is_a: UBERON:0003704 ! intrahepatic bile duct +relationship: BFO:0000050 UBERON:0001279 ! part of portal triad +relationship: RO:0002176 UBERON:0004058 ! biliary ductule +relationship: RO:0002176 UBERON:0014719 ! intralobular duct +relationship: RO:0002433 UBERON:0001279 ! portal triad + +[Term] +id: UBERON:0001262 +name: wall of intestine +def: "An anatomical wall that is part of a intestine [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000647 +xref: EMAPA:35444 +xref: FMA:15949 +xref: MA:0001525 +xref: MA:0002693 +xref: NCIT:C49478 +is_a: UBERON:0000328 ! gut wall +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0000160 ! part of intestine + +[Term] +id: UBERON:0001263 +name: pancreatic acinus +def: "The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct." [MP:0009145] +xref: EMAPA:35651 +xref: FMA:16011 +xref: MA:0002417 +xref: NCIT:C49268 +xref: SCTID:247604006 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0013232 ! serous acinus +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000050 UBERON:0007324 ! part of pancreatic lobule +relationship: RO:0002433 UBERON:0000017 ! exocrine pancreas +relationship: RO:0002473 CL:0002064 ! pancreatic acinar cell + +[Term] +id: UBERON:0001264 +name: pancreas +def: "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]." [GO:0031016] +xref: AAO:0010112 +xref: BTO:0000988 +xref: CALOHA:TS-0736 +xref: EFO:0000855 +xref: EHDAA2:0001367 +xref: EHDAA:6893 +xref: EMAPA:17503 +xref: EV:0100092 +xref: FMA:7198 +xref: GAID:334 +xref: galen:Pancreas +xref: MA:0000120 +xref: MAT:0000075 +xref: MESH:D010179 +xref: MIAA:0000075 +xref: NCIT:C12393 +xref: SCTID:181277001 +xref: TAO:0000140 +xref: VHOG:0000050 +xref: Wikipedia:Pancreas +xref: XAO:0000136 +xref: ZFA:0000140 +is_a: UBERON:0002075 ! viscus +relationship: BFO:0000051 UBERON:0000016 ! has part endocrine pancreas +relationship: BFO:0000051 UBERON:0000017 {gci_filler="NCBITaxon:89593", gci_relation="BFO:0000050"} ! has part exocrine pancreas +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002254 UBERON:0003923 ! dorsal pancreatic bud +relationship: RO:0002254 UBERON:0003924 ! ventral pancreatic bud + +[Term] +id: UBERON:0001265 +name: trabecula of spleen +def: "A trabecula that is part of a spleen." [OBOL:automatic] +xref: EMAPA:35808 +xref: FMA:16027 +xref: MA:0000758 +xref: NCIT:C33607 +xref: SCTID:61987002 +xref: Wikipedia:Trabeculae_of_spleen +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0000440 ! trabecula +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:1000024 ! part of parenchyma of spleen + [Term] id: UBERON:0001268 name: peritoneal fluid +def: "Transudate contained in the peritoneal cavity." [FMA:16515] +xref: BTO:0001031 +xref: EMAPA:35683 +xref: FMA:16515 +xref: MA:0002531 +xref: ncithesaurus:Peritoneal_Fluid +xref: Wikipedia:Peritoneal_fluid is_a: UBERON:0007779 ! transudate is_a: UBERON:0007794 ! secretion of serous gland is_a: UBERON:0036217 ! coelomic fluid @@ -33685,6 +46928,15 @@ relationship: RO:0001025 UBERON:0001179 ! peritoneal cavity [Term] id: UBERON:0001276 name: epithelium of stomach +def: "The epithelial layer of the stomach ." [MP:0000471] +xref: BTO:0000500 +xref: CALOHA:TS-2068 +xref: EHDAA2:0001918 +xref: EMAPA:17023 +xref: FMA:17091 +xref: MA:0001610 +xref: SCTID:64977002 +xref: VHOG:0001433 is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0004808 ! gastrointestinal system epithelium @@ -33694,9 +46946,155 @@ intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach relationship: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach relationship: RO:0002433 UBERON:0001199 ! mucosa of stomach +[Term] +id: UBERON:0001277 +name: intestinal epithelium +def: "Epithelial layer that lines the intestine." [UBERON:cjm] +xref: BTO:0000781 +xref: EMAPA:32873 +xref: FMA:17229 +xref: MA:0001536 +xref: NCIT:C49240 +xref: SCTID:266135004 +xref: TAO:0005124 +xref: Wikipedia:Intestinal_epithelium +xref: ZFA:0005124 +is_a: UBERON:0000485 ! simple columnar epithelium +is_a: UBERON:0003350 ! epithelium of mucosa +is_a: UBERON:0003929 ! digestive tract epithelium +is_a: UBERON:0004808 ! gastrointestinal system epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001242 ! part of intestinal mucosa +relationship: RO:0002433 UBERON:0000160 ! intestine + +[Term] +id: UBERON:0001278 +name: epithelium of large intestine +def: "An epithelium that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: CALOHA:TS-2105 +xref: EMAPA:35466 +xref: FMA:17301 +xref: MA:0001545 +is_a: UBERON:0001277 ! intestinal epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001207 ! part of mucosa of large intestine + +[Term] +id: UBERON:0001279 +name: portal triad +def: "A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MGI:csmith, MP:0008993] +xref: FMA:17523 +xref: MA:0002499 +xref: NCIT:C33342 +xref: SCTID:362192000 +xref: Wikipedia:Portal_triad +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0034921 ! multi organ part structure +relationship: BFO:0000050 UBERON:0001172 ! part of hepatic acinus +relationship: BFO:0000051 UBERON:0001193 ! has part hepatic artery +relationship: BFO:0000051 UBERON:0002017 ! has part portal vein +relationship: BFO:0000051 UBERON:0003704 ! has part intrahepatic bile duct +relationship: RO:0002433 UBERON:0001171 ! portal lobule + +[Term] +id: UBERON:0001280 +name: liver parenchyma +def: "The functional units of the liver including the lobules." [MP:0008986] +xref: AAO:0010405 +xref: EHDAA2:0001004 +xref: EHDAA:2201 +xref: EMAPA:17203 +xref: FMA:17540 +xref: MA:0000366 +xref: NCIT:C32735 +xref: SCTID:363535004 +xref: UMLS:C0736268 +xref: VHOG:0000539 +xref: XAO:0000454 +is_a: UBERON:0000353 ! parenchyma +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver +relationship: RO:0002202 UBERON:0008835 ! hepatic diverticulum +relationship: RO:0002433 UBERON:0002107 ! liver + +[Term] +id: UBERON:0001281 +name: hepatic sinusoid +def: "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers." [Wikipedia:Hepatic_sinusoid, ZFIN:curator] +xref: EHDAA2:0000999 +xref: EMAPA:17365 +xref: FMA:17543 +xref: MA:0000367 +xref: NCIT:C32733 +xref: SCTID:67435004 +xref: TAO:0005091 +xref: VHOG:0000708 +xref: Wikipedia:Hepatic_sinusoid +xref: ZFA:0005091 +is_a: UBERON:0003909 ! sinusoid +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0003909 ! sinusoid +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0004647 ! part of liver lobule +relationship: BFO:0000050 UBERON:0006877 ! part of vasculature of liver +relationship: RO:0002170 UBERON:0006841 ! central vein of liver +relationship: RO:0002226 UBERON:0001113 ! lobe of liver +relationship: RO:0002433 UBERON:0004647 ! liver lobule + +[Term] +id: UBERON:0001282 +name: intralobular bile duct +def: "The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule." [MGI:csmith, MP:0009499] +xref: FMA:17545 +xref: MA:0002669 +xref: NCIT:C32255 +xref: SCTID:227002 +xref: SCTID:269922006 +xref: Wikipedia:Canals_of_Hering +is_a: UBERON:0003704 ! intrahepatic bile duct +is_a: UBERON:0014716 ! interlobular duct +relationship: BFO:0000050 UBERON:0001172 ! part of hepatic acinus +relationship: BFO:0000050 UBERON:0004647 ! part of liver lobule +relationship: BFO:0000051 CL:0000182 ! has part hepatocyte +relationship: BFO:0000051 CL:1000488 ! has part cholangiocyte +relationship: RO:0002433 UBERON:0004647 ! liver lobule + +[Term] +id: UBERON:0001353 +name: anal region +def: "The anus and surrounding regions. Encompasses both internal and external regions, where present." [https://orcid.org/0000-0002-6601-2165] +xref: EFO:0000847 +xref: EHDAA2:0000122 +xref: EHDAA:2931 +xref: EMAPA:16831 +xref: MA:0000329 +xref: MAT:0000042 +xref: MIAA:0000042 +xref: NCIT:C32069 +xref: SCTID:362680001 +xref: VHOG:0000395 +xref: WBbt:0006919 +is_a: UBERON:0000475 ! organism subdivision +relationship: RO:0002131 UBERON:0006866 ! overlaps terminal part of digestive tract +relationship: RO:0002254 UBERON:0000931 ! proctodeum + [Term] id: UBERON:0001366 name: parietal peritoneum +def: "The outer layer of peritoneum that is attached to the abdominal and pelvic walls." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Peritoneum#Types] +xref: AAO:0010816 +xref: EMAPA:16591 +xref: FMA:21451 +xref: SCTID:362700006 +xref: TAO:0005131 +xref: VHOG:0001527 +xref: Wikipedia:Parietal_peritoneum +xref: ZFA:0005131 is_a: UBERON:0022351 ! parietal serous membrane intersection_of: UBERON:0022351 ! parietal serous membrane intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum @@ -33706,6 +47104,13 @@ relationship: RO:0002371 UBERON:0003697 ! abdominal wall [Term] id: UBERON:0001416 name: skin of abdomen +def: "A zone of skin that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] +xref: EFO:0000214 +xref: FMA:22988 +xref: FMA:23000 +xref: MA:0000523 +xref: NCIT:C52758 +xref: SCTID:361707007 is_a: UBERON:0003836 ! abdominal segment skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -33714,6 +47119,12 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0001417 name: skin of neck +def: "A zone of skin that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: FMA:23021 +xref: FMA:23022 +xref: MA:0000590 +xref: NCIT:C52756 +xref: SCTID:361705004 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -33722,6 +47133,11 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0001418 name: skin of thorax +def: "A zone of skin that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: FMA:23028 +xref: FMA:23029 +xref: MA:0000564 +xref: SCTID:281723000 is_a: UBERON:0001085 ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -33730,6 +47146,11 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0001421 name: pectoral girdle region +def: "An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions." [FMA:23217, https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: FMA:23217 +xref: galen:ShoulderGirdle +xref: SCTID:229759004 +xref: VSAO:0000305 is_a: UBERON:0007823 ! appendage girdle region is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0007823 ! appendage girdle region @@ -33742,16 +47163,33 @@ relationship: RO:0002551 UBERON:0007831 ! pectoral girdle skeleton [Term] id: UBERON:0001434 name: skeletal system +def: "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000027] +xref: AAO:0000566 +xref: BTO:0001486 +xref: CALOHA:TS-1320 +xref: EFO:0000806 +xref: EHDAA2:0003168 +xref: EMAPA:35773 +xref: FMA:23881 +xref: MA:0000018 +xref: NCIT:C12788 +xref: TAO:0000434 +xref: VHOG:0001254 +xref: VSAO:0000027 +xref: XAO:0003060 +xref: ZFA:0000434 is_a: UBERON:0011216 ! organ system subdivision intersection_of: UBERON:0011216 ! organ system subdivision intersection_of: BFO:0000051 UBERON:0004288 ! has part skeleton intersection_of: BFO:0000051 UBERON:0004770 ! has part articular system disjoint_from: UBERON:0001474 ! bone element disjoint_from: UBERON:0002204 ! musculoskeletal system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000050 UBERON:0002204 ! part of musculoskeletal system @@ -33762,12 +47200,28 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0001444 name: subdivision of head +xref: FMA:24218 +xref: SCTID:123852005 +xref: XAO:0000040 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0001456 name: face +def: "A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc)." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0003369 +xref: CALOHA:TS-2216 +xref: EMAPA:32763 +xref: FMA:24728 +xref: GAID:64 +xref: galen:Face +xref: HAO:0000316 +xref: MA:0002473 +xref: MESH:D005145 +xref: NCIT:C13071 +xref: SCTID:302549007 +xref: Wikipedia:Face is_a: UBERON:0001444 ! subdivision of head relationship: BFO:0000051 UBERON:0000018 {gci_filler="NCBITaxon:50557", gci_relation="BFO:0000050"} ! has part compound eye relationship: BFO:0000051 UBERON:0000165 ! has part mouth @@ -33778,6 +47232,11 @@ relationship: RO:0002551 UBERON:0011156 {gci_filler="NCBITaxon:7742", gci_relati [Term] id: UBERON:0001458 name: skin of lip +def: "A zone of skin that is part of a lip [Automatically generated definition]." [OBOL:automatic] +xref: FMA:24764 +xref: MA:0001579 +xref: NCIT:C12291 +xref: SCTID:244092005 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001833 ! part of lip @@ -33786,6 +47245,31 @@ relationship: BFO:0000050 UBERON:0001833 ! part of lip [Term] id: UBERON:0001474 name: bone element +def: "Skeletal element that is composed of bone tissue." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/277, PSPUB:0000170, VSAO:0000057] +xref: AAO:0000047 +xref: AEO:0000082 +xref: BTO:0000140 +xref: CALOHA:TS-0088 +xref: EFO:0000298 +xref: EHDAA2:0003082 +xref: EMAPA:32782 +xref: ENVO:00002039 +xref: EV:0100140 +xref: FMA:30317 +xref: FMA:5018 +xref: GAID:92 +xref: galen:Bone +xref: MA:0001459 +xref: MAT:0000299 +xref: MIAA:0000299 +xref: NCIT:C12366 +xref: SCTID:90780006 +xref: TAO:0001514 +xref: VHOG:0001190 +xref: VSAO:0000057 +xref: Wikipedia:Bone +xref: XAO:0000169 +xref: ZFA:0001514 is_a: UBERON:0004765 ! skeletal element intersection_of: UBERON:0004765 ! skeletal element intersection_of: RO:0002473 UBERON:0002481 ! bone tissue @@ -33797,6 +47281,16 @@ relationship: RO:0002473 UBERON:0002481 ! bone tissue [Term] id: UBERON:0001484 name: articular capsule +def: "An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]." [Wikipedia:Articular_capsule] +xref: FMA:34836 +xref: GAID:263 +xref: galen:JointCapsule +xref: MA:0001519 +xref: MESH:D017746 +xref: NCIT:C32259 +xref: NCIT:C84388 +xref: SCTID:182238002 +xref: Wikipedia:Articular_capsule is_a: UBERON:0000094 ! membrane organ intersection_of: UBERON:0000094 ! membrane organ intersection_of: BFO:0000051 UBERON:0007616 ! has part layer of synovial tissue @@ -33807,17 +47301,36 @@ relationship: RO:0002221 UBERON:0002217 ! synovial joint [Term] id: UBERON:0001496 name: ascending aorta +def: "The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]." [GO:0035905, Wikipedia:Ascending_aorta] +xref: EHDAA2:0000147 +xref: EHDAA:9828 +xref: EMAPA:17014 +xref: FMA:3736 +xref: MA:0002570 +xref: NCIT:C32150 +xref: SCTID:181299009 +xref: Wikipedia:Ascending_aorta is_a: UBERON:0001515 ! thoracic aorta relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta relationship: RO:0002202 UBERON:0005338 ! outflow tract aortic component relationship: RO:0002254 UBERON:0002061 ! truncus arteriosus relationship: RO:0002254 UBERON:0005432 ! aortic sac relationship: RO:0002433 UBERON:0001515 ! thoracic aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001508 name: arch of aorta +def: "The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery." [ISBN:0-683-40008-8, MP:0004113] +xref: BTO:0000157 +xref: EFO:0002526 +xref: EHDAA2:0000132 +xref: EMAPA:17613 +xref: FMA:3768 +xref: GAID:471 +xref: MA:0000475 +xref: SCTID:181300001 +xref: VHOG:0001196 +xref: Wikipedia:Arch_of_aorta is_a: UBERON:0001515 ! thoracic aorta relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta relationship: RO:0002170 UBERON:0001496 ! ascending aorta @@ -33825,21 +47338,38 @@ relationship: RO:0002202 UBERON:0003121 ! pharyngeal arch artery 4 relationship: RO:0002254 UBERON:0005432 ! aortic sac relationship: RO:0002254 UBERON:0005613 ! left dorsal aorta relationship: RO:0002433 UBERON:0001515 ! thoracic aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001514 name: descending aorta +def: "The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]." [GO:0035906, Wikipedia:Descending_aorta] +xref: EMAPA:18606 +xref: FMA:3784 +xref: MA:0002571 +xref: NCIT:C32455 +xref: SCTID:261399002 +xref: Wikipedia:Descending_aorta is_a: UBERON:0005800 ! section of aorta relationship: RO:0002170 UBERON:0001508 ! arch of aorta relationship: RO:0002202 UBERON:0005805 ! dorsal aorta relationship: RO:0002254 UBERON:0005613 ! left dorsal aorta relationship: RO:0002254 UBERON:0005622 ! right dorsal aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001515 name: thoracic aorta +def: "The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." [http://www.medterms.com, MP:0010468] +xref: BTO:0000157 +xref: EFO:0002525 +xref: EMAPA:18603 +xref: FMA:3786 +xref: GAID:471 +xref: galen:ThoracicAorta +xref: MA:0002569 +xref: MESH:D001013 +xref: NCIT:C33766 +xref: SCTID:302510009 +xref: Wikipedia:Thoracic_aorta is_a: UBERON:0005800 ! section of aorta intersection_of: UBERON:0005800 ! section of aorta intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -33849,139 +47379,318 @@ relationship: RO:0002433 UBERON:0000947 ! aorta [Term] id: UBERON:0001516 name: abdominal aorta +def: "Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]." [BTO:0002976, Wikipedia:Abdominal_aorta] +xref: BTO:0002976 +xref: EFO:0002524 +xref: EMAPA:17856 +xref: FMA:3789 +xref: GAID:470 +xref: galen:AbdominalAorta +xref: MA:0000474 +xref: MESH:D001012 +xref: NCIT:C32038 +xref: SCTID:244231007 +xref: Wikipedia:Abdominal_aorta is_a: UBERON:0005800 ! section of aorta relationship: BFO:0000050 UBERON:0001514 ! part of descending aorta relationship: RO:0002131 UBERON:0000916 ! overlaps abdomen relationship: RO:0002170 UBERON:0002345 ! descending thoracic aorta relationship: RO:0002433 UBERON:0001514 ! descending aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001529 name: brachiocephalic artery +def: "The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery." [MGI:csmith, MP:0010663] +xref: EFO:0002550 +xref: EHDAA2:0000835 +xref: EMAPA:17615 +xref: FMA:3932 +xref: GAID:476 +xref: galen:BrachioCephalicArtery +xref: MA:0001922 +xref: MESH:D016122 +xref: NCIT:C32814 +xref: SCTID:244244002 +xref: Wikipedia:Brachiocephalic_artery is_a: UBERON:0004573 ! systemic artery relationship: BFO:0000050 UBERON:0007204 ! part of brachiocephalic vasculature relationship: channels_from UBERON:0001508 ! arch of aorta relationship: RO:0002170 UBERON:0001508 ! arch of aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001530 name: common carotid artery plus branches +def: "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]." [Wikipedia:Common_carotid_artery] +xref: CALOHA:TS-0116 +xref: EHDAA2:0000217 +xref: EHDAA:7331 +xref: EMAPA:17855 +xref: FMA:3939 +xref: GAID:479 +xref: MA:0001926 +xref: MESH:D017536 +xref: NCIT:C32352 +xref: SCTID:362041005 +xref: VHOG:0000272 +xref: Wikipedia:Common_carotid_artery is_a: UBERON:0004573 ! systemic artery relationship: RO:0002170 UBERON:0001508 ! arch of aorta relationship: RO:0002202 UBERON:0004363 ! pharyngeal arch artery relationship: RO:0002488 UBERON:0000068 ! embryo stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001533 name: subclavian artery +def: "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584] +xref: AAO:0010232 +xref: EHDAA2:0001933 +xref: EHDAA:4357 +xref: EMAPA:17617 +xref: FMA:3951 +xref: GAID:511 +xref: MA:0002045 +xref: MESH:D013348 +xref: NCIT:C33643 +xref: SCTID:265790007 +xref: TAO:0005086 +xref: Wikipedia:Subclavian_artery +xref: XAO:0000365 +xref: ZFA:0005086 is_a: UBERON:0004573 ! systemic artery relationship: RO:0002131 UBERON:0000915 ! overlaps thoracic segment of trunk relationship: RO:0002170 UBERON:0001508 ! arch of aorta relationship: RO:0002178 UBERON:0004710 ! pectoral appendage relationship: RO:0002202 UBERON:0002457 ! intersomitic artery relationship: RO:0002202 UBERON:0005622 ! right dorsal aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001534 name: right subclavian artery +def: "The subclavian artery that supplies the right pectoral appendage." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0004514 +xref: FMA:3953 +xref: MA:0002047 +xref: NCIT:C33490 +xref: SCTID:244246000 +xref: Wikipedia:Subclavian_artery is_a: UBERON:0001533 ! subclavian artery is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001533 ! subclavian artery intersection_of: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism relationship: RO:0002170 UBERON:0001529 ! brachiocephalic artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001555 name: digestive tract +def: "A tube extending from the mouth to the anus." [https://github.com/geneontology/go-ontology/issues/7549, Wikipedia:Talk\:Human_gastrointestinal_tract] +xref: AAO:0010023 +xref: BILA:0000083 +xref: BTO:0000511 +xref: BTO:0000545 +xref: EHDAA2:0000726 +xref: EHDAA:518 +xref: EMAPA:16247 +xref: FMA:45615 +xref: galen:AlimentaryTract +xref: MA:0000917 +xref: NCIT:C34082 +xref: TAO:0000112 +xref: TGMA:0001819 +xref: VHOG:0000309 +xref: WBbt:0005743 +xref: ZFA:0000112 is_a: UBERON:0000025 ! tube relationship: BFO:0000050 UBERON:0001007 ! part of digestive system relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa relationship: RO:0002176 UBERON:0000165 ! mouth relationship: RO:0002495 UBERON:0007026 ! presumptive gut -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001558 name: lower respiratory tract +def: "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lower_respiratory_tract] +xref: EHDAA2:0001036 +xref: EMAPA:16738 +xref: FMA:45662 +xref: MA:0000435 +xref: SCTID:281488008 +xref: VHOG:0000382 +xref: Wikipedia:Lower_respiratory_tract is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract relationship: BFO:0000051 UBERON:0000170 ! has part pair of lungs -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001584 name: left subclavian artery +def: "The subclavian artery that supplies the left pectoral appendage." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:4694 +xref: MA:0002046 +xref: NCIT:C32972 +xref: SCTID:244245001 +xref: Wikipedia:Subclavian_artery is_a: UBERON:0001533 ! subclavian artery is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001533 ! subclavian artery intersection_of: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism relationship: channels_from UBERON:0001508 ! arch of aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001585 name: anterior vena cava +def: "A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Superior_vena_cava] +xref: BTO:0002683 +xref: EHDAA2:0001962 +xref: EHDAA:8726 +xref: EMAPA:18417 +xref: FMA:4720 +xref: GAID:549 +xref: galen:SuperiorVenaCava +xref: MA:0000481 +xref: MESH:D014683 +xref: NCIT:C12816 +xref: SCTID:181368006 +xref: VHOG:0001195 +xref: Wikipedia:Superior_vena_cava is_a: UBERON:0004087 ! vena cava intersection_of: UBERON:0004087 ! vena cava intersection_of: RO:0002179 UBERON:0000153 ! anterior region of body relationship: RO:0002170 UBERON:0002078 ! right cardiac atrium relationship: RO:0002179 UBERON:0000153 ! anterior region of body -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001586 name: internal jugular vein +def: "One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]." [Wikipedia:Internal_jugular_vein] +xref: AAO:0010236 +xref: EHDAA2:0000877 +xref: EHDAA:5407 +xref: EMAPA:17620 +xref: FMA:4724 +xref: galen:InternalJugularVein +xref: MA:0002157 +xref: NCIT:C32849 +xref: RETIRED_EHDAA2:0000878 +xref: SCTID:181372005 +xref: Wikipedia:Internal_jugular_vein +xref: XAO:0000382 is_a: UBERON:0004711 ! jugular vein relationship: RO:0002170 UBERON:0003711 ! brachiocephalic vein relationship: RO:0002179 UBERON:0000955 ! brain relationship: RO:0002179 UBERON:0001456 ! face -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001592 name: bronchial vein +def: "The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]." [Wikipedia:Bronchial_veins] +xref: EMAPA:36284 +xref: FMA:4749 +xref: MA:0002088 +xref: NCIT:C53031 +xref: SCTID:198293000 +xref: Wikipedia:Bronchial_veins is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0002185 ! bronchus relationship: RO:0002179 UBERON:0002185 ! bronchus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001605 name: ciliary muscle +def: "The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]." [Wikipedia:Ciliary_muscle] +xref: BTO:0000654 +xref: EMAPA:35240 +xref: FMA:49151 +xref: MA:0001269 +xref: NCIT:C32315 +xref: SCTID:280862009 +xref: Wikipedia:Ciliary_muscle is_a: UBERON:0003386 ! smooth muscle of eye is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0011222 ! intra-ocular muscle relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001606 name: muscle of iris +xref: FMA:49154 +xref: MA:0001287 +xref: SCTID:280888007 +xref: Wikipedia:Iris_muscle is_a: UBERON:0011222 ! intra-ocular muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000050 UBERON:0001769 ! part of iris +[Term] +id: UBERON:0001607 +name: sphincter pupillae +def: "A sphincter muscle that is part of the iris." [Wikipedia:Iris_sphincter_muscle] +xref: BTO:0000656 +xref: EMAPA:35788 +xref: FMA:49157 +xref: MA:0001289 +xref: NCIT:C33586 +xref: SCTID:280889004 +xref: Wikipedia:Iris_sphincter_muscle +is_a: UBERON:0001606 ! muscle of iris +is_a: UBERON:0004234 ! iris smooth muscle +is_a: UBERON:0007521 ! smooth muscle sphincter +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0001769 ! part of iris +relationship: RO:0002202 UBERON:0002346 ! neurectoderm +relationship: RO:0002372 UBERON:0001769 ! iris +relationship: RO:0002373 UBERON:0001769 ! iris +relationship: RO:0002568 UBERON:0001608 ! dilatator pupillae + +[Term] +id: UBERON:0001608 +name: dilatator pupillae +def: "A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]." [Wikipedia:Iris_dilator_muscle] +xref: BTO:0001371 +xref: EMAPA:35286 +xref: FMA:49158 +xref: MA:0001288 +xref: NCIT:C32463 +xref: SCTID:280890008 +xref: Wikipedia:Iris_dilator_muscle +is_a: UBERON:0004234 ! iris smooth muscle +relationship: RO:0002202 UBERON:0002346 ! neurectoderm +relationship: RO:0002372 UBERON:0001769 ! iris +relationship: RO:0002373 UBERON:0001769 ! iris +relationship: RO:0002568 UBERON:0001607 ! sphincter pupillae + [Term] id: UBERON:0001612 name: facial artery +def: "A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]." [Wikipedia:Facial_artery] +xref: EMAPA:19213 +xref: FMA:49549 +xref: MA:0001950 +xref: NCIT:C32578 +xref: SCTID:181328007 +xref: Wikipedia:Facial_artery is_a: UBERON:0035398 ! branch of external carotid artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0001456 ! face intersection_of: RO:0002252 UBERON:0001070 ! external carotid artery relationship: RO:0002178 UBERON:0001456 ! face -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001630 name: muscle organ +def: "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]." [GO:0007517] +xref: EV:0100146 +xref: FMA:5022 +xref: GAID:131 +xref: galen:Muscle +xref: MA:0000015 +xref: SCTID:71616004 +xref: TAO:0005145 +xref: VHOG:0001245 +xref: XAO:0000172 +xref: ZFA:0005145 is_a: UBERON:0000062 ! organ is_a: UBERON:0005090 ! muscle structure intersection_of: UBERON:0000062 ! organ @@ -33992,21 +47701,128 @@ relationship: RO:0002473 UBERON:0002385 ! muscle tissue [Term] id: UBERON:0001637 name: artery +def: "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]." [AEO:JB] +xref: AAO:0010211 +xref: AEO:0000208 +xref: BTO:0000573 +xref: CALOHA:TS-0054 +xref: EFO:0000814 +xref: EHDAA2:0003253 +xref: EMAPA:35147 +xref: EV:0100026 +xref: FMA:50720 +xref: GAID:468 +xref: galen:Artery +xref: MA:0000064 +xref: MAT:0000034 +xref: MESH:D001158 +xref: MIAA:0000034 +xref: NCIT:C12372 +xref: SCTID:362877004 +xref: TAO:0000005 +xref: VHOG:0001251 +xref: Wikipedia:Artery +xref: XAO:0000114 +xref: ZFA:0000005 is_a: UBERON:0003509 ! arterial blood vessel relationship: channels_from UBERON:0000948 ! heart [Term] id: UBERON:0001638 name: vein +def: "Any of the tubular branching vessels that carry blood from the capillaries toward the heart." [Wikipedia:Vein] +xref: AAO:0010212 +xref: AEO:0000209 +xref: BTO:0000234 +xref: CALOHA:TS-1108 +xref: EFO:0000816 +xref: EHDAA2:0003254 +xref: EMAPA:35906 +xref: EV:0100031 +xref: FMA:50723 +xref: GAID:492 +xref: galen:Vein +xref: MA:0000067 +xref: MAT:0000037 +xref: MESH:D014680 +xref: MIAA:0000037 +xref: NCIT:C12814 +xref: SCTID:181367001 +xref: TAO:0000082 +xref: VHOG:0001743 +xref: Wikipedia:Vein +xref: XAO:0000115 +xref: ZFA:0000082 is_a: UBERON:0003920 ! venous blood vessel intersection_of: UBERON:0003920 ! venous blood vessel intersection_of: channel_for UBERON:0013756 ! venous blood relationship: channel_for UBERON:0013756 ! venous blood relationship: channels_from UBERON:0001982 ! capillary +[Term] +id: UBERON:0001639 +name: hepatic portal vein +def: "A portal vein that transports nutrients from the digestive tract to the liver[Kardong]." [http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376, ISBN:0073040584, Wikipedia:Hepatic_portal_vein] +xref: AAO:0010214 +xref: FMA:50735 +xref: MA:0002132 +xref: TAO:0005090 +xref: VHOG:0000642 +xref: Wikipedia:Hepatic_portal_vein +xref: ZFA:0005090 +is_a: UBERON:0002017 ! portal vein +relationship: BFO:0000050 UBERON:0010194 ! part of hepatic portal system +relationship: channels_into UBERON:0002107 ! liver +relationship: RO:0002131 UBERON:0002107 ! overlaps liver + +[Term] +id: UBERON:0001640 +name: celiac artery +def: "The first major branch of the abdominal aorta." [Wikipedia:Celiac_artery] +comment: dorsal aorta in Kardong +xref: EHDAA2:0004519 +xref: EMAPA:35202 +xref: FMA:50737 +xref: GAID:483 +xref: MA:0001931 +xref: MESH:D002445 +xref: NCIT:C52846 +xref: SCTID:181340007 +xref: Wikipedia:Celiac_artery +is_a: UBERON:0012254 ! abdominal aorta artery +relationship: indirectly_supplies UBERON:0000160 ! intestine +relationship: indirectly_supplies UBERON:0000945 ! stomach +relationship: indirectly_supplies UBERON:0002106 ! spleen +relationship: indirectly_supplies UBERON:0002107 ! liver + [Term] id: UBERON:0001645 name: trigeminal nerve +def: "Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw)." [ISBN:0471209627, Wikipedia:Trigeminal_nerve] +xref: AAO:0010470 +xref: BAMS:5n +xref: BAMS:nV +xref: BAMS:Vn +xref: BIRNLEX:869 +xref: BM:VN +xref: BTO:0001072 +xref: EFO:0001402 +xref: EHDAA2:0002084 +xref: EHDAA:3738 +xref: EMAPA:17576 +xref: FMA:50866 +xref: GAID:726 +xref: MA:0001100 +xref: MBA:901 +xref: MESH:D014276 +xref: MFMO:0000093 +xref: NCIT:C12806 +xref: SCTID:362459002 +xref: TAO:0000697 +xref: VHOG:0000704 +xref: Wikipedia:Trigeminal_nerve +xref: XAO:0003092 +xref: ZFA:0000697 is_a: UBERON:0001785 ! cranial nerve intersection_of: UBERON:0001785 ! cranial nerve intersection_of: extends_fibers_into UBERON:0002925 ! trigeminal nucleus @@ -34018,40 +47834,81 @@ relationship: RO:0002134 UBERON:0000165 ! mouth relationship: RO:0002134 UBERON:0011648 ! jaw muscle relationship: RO:0002134 UBERON:1000021 ! skin of face relationship: RO:0002254 UBERON:0005239 ! basal plate metencephalon -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001651 name: right pulmonary artery +def: "The pulmonary artery that supplies the right lung." [UBERON:cjm] +xref: FMA:50872 +xref: galen:RightPulmonaryArtery +xref: MA:0002500 +xref: NCIT:C33489 +xref: SCTID:244235003 +xref: Wikipedia:Right_pulmonary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0002167 ! right lung relationship: RO:0002170 UBERON:0002333 ! pulmonary trunk relationship: RO:0002178 UBERON:0002167 ! right lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001652 name: left pulmonary artery +def: "The pulmonary artery that supplies the left lung." [UBERON:cjm] +xref: FMA:50873 +xref: galen:LeftPulmonaryArtery +xref: MA:0002032 +xref: NCIT:C32971 +xref: SCTID:244234004 +xref: Wikipedia:Left_pulmonary_artery is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0002168 ! left lung relationship: RO:0002170 UBERON:0002333 ! pulmonary trunk relationship: RO:0002178 UBERON:0002168 ! left lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001653 name: facial vein +def: "The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]." [Wikipedia:Facial_vein] +xref: AAO:0010513 +xref: EMAPA:19220 +xref: FMA:50874 +xref: MA:0002115 +xref: NCIT:C32579 +xref: SCTID:181374006 +xref: Wikipedia:Facial_vein is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009141 ! craniocervical region vein relationship: BFO:0000050 UBERON:0001456 ! part of face relationship: RO:0002376 UBERON:0001586 ! internal jugular vein -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001675 name: trigeminal ganglion +def: "The cranial ganglion that is associated with and extends fibers into the trigeminal nerve." [http://orcid.org/0000-0002-6601-2165, http://www.ncbi.nlm.nih.gov/books/NBK53171, https://github.com/obophenotype/uberon/issues/693] +xref: AAO:0011107 +xref: BAMS:5Gn +xref: BAMS:GV +xref: BTO:0001231 +xref: EFO:0000903 +xref: EHDAA2:0002085 +xref: EHDAA:2113 +xref: EMAPA:16797 +xref: FMA:52618 +xref: GAID:725 +xref: MA:0001080 +xref: MAT:0000511 +xref: MESH:D012668 +xref: NCIT:C62642 +xref: neuronames:1402 +xref: SCTID:244449009 +xref: TAO:0000295 +xref: VHOG:0000694 +xref: Wikipedia:Trigeminal_ganglion +xref: XAO:0000427 +xref: XAO:0000428 +xref: ZFA:0000295 is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0001800 ! sensory ganglion is_a: UBERON:0010313 ! neural crest-derived structure @@ -34063,6 +47920,15 @@ relationship: RO:0002495 UBERON:0006304 ! future trigeminal ganglion [Term] id: UBERON:0001676 name: occipital bone +def: "The bone at the lower, posterior part of the skull." [ISBN:0-683-40008-8, MP:0005269] +xref: EMAPA:25112 +xref: FMA:52735 +xref: GAID:227 +xref: MA:0001468 +xref: MESH:D009777 +xref: NCIT:C12757 +xref: SCTID:181796003 +xref: Wikipedia:Occipital_bone is_a: UBERON:0010428 ! flat bone is_a: UBERON:0011164 ! neurocranium bone relationship: BFO:0000050 UBERON:0005902 ! part of occipital region @@ -34071,21 +47937,110 @@ relationship: RO:0002131 UBERON:0003113 ! overlaps dermatocranium relationship: RO:0002160 NCBITaxon:117570 ! Teleostomi relationship: RO:0002202 UBERON:0003089 ! sclerotome relationship: RO:0002221 UBERON:0003687 ! foramen magnum -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001677 +name: sphenoid bone +def: "An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended." [Wikipedia:Sphenoid_bone] +xref: CALOHA:TS-2343 +xref: EMAPA:18340 +xref: FMA:52736 +xref: GAID:230 +xref: MA:0001472 +xref: MESH:D013100 +xref: NCIT:C12790 +xref: SCTID:272676008 +xref: Wikipedia:Sphenoid_bone +is_a: UBERON:0002513 ! endochondral bone +is_a: UBERON:0003462 ! facial bone +is_a: UBERON:0008193 ! pneumatized bone +is_a: UBERON:0015060 ! sphenoid endochondral element +intersection_of: UBERON:0015060 ! sphenoid endochondral element +intersection_of: RO:0002473 UBERON:0002481 ! bone tissue +relationship: RO:0002131 UBERON:0002241 ! overlaps chondrocranium +relationship: RO:0002131 UBERON:0003113 ! overlaps dermatocranium +relationship: RO:0002131 UBERON:0008895 ! overlaps splanchnocranium +relationship: RO:0002202 UBERON:0009193 ! sphenoid cartilage element + +[Term] +id: UBERON:0001679 +name: ethmoid bone +def: "A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]." [Wikipedia:Ethmoid_bone] +xref: BTO:0004140 +xref: EMAPA:19018 +xref: FMA:52740 +xref: GAID:212 +xref: MA:0001483 +xref: MESH:D005004 +xref: NCIT:C12711 +xref: SCTID:272674006 +xref: VHOG:0001317 +xref: Wikipedia:Ethmoid_bone +is_a: UBERON:0002513 ! endochondral bone +is_a: UBERON:0003462 ! facial bone +is_a: UBERON:0011164 ! neurocranium bone +relationship: BFO:0000050 UBERON:0002517 ! part of basicranium +relationship: BFO:0000050 UBERON:0011241 ! part of ethmoid region +relationship: RO:0002202 UBERON:0006227 ! ethmoid bone primordium +relationship: RO:0002433 UBERON:0011156 ! facial skeleton + +[Term] +id: UBERON:0001697 +name: orbit of skull +def: "Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball." [http://orcid.org/0000-0002-6601-2165, TAO:0001410, Wikipedia:Orbit_(anatomy)] +xref: BTO:0004687 +xref: FMA:53074 +xref: GAID:223 +xref: galen:Orbit +xref: MA:0002482 +xref: MESH:D009915 +xref: NCIT:C12347 +xref: TAO:0001410 +xref: Wikipedia:Orbit_(anatomy) +xref: XAO:0003171 +xref: ZFA:0001410 +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010912 ! subdivision of skeleton +is_a: UBERON:0015212 ! lateral structure +relationship: BFO:0000050 UBERON:0004088 ! part of orbital region +relationship: BFO:0000050 UBERON:0011156 ! part of facial skeleton +relationship: BSPO:0000126 UBERON:0011156 ! facial skeleton +relationship: RO:0001015 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0001703 name: neurocranium +def: "Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof." [PMID:11523816, TAO:MAH, Wikipedia:Neuroranium, ZFA:0001580] +xref: FMA:53672 +xref: MA:0000317 +xref: SCTID:361731002 +xref: TAO:0001580 +xref: Wikipedia:Neuroranium +xref: XAO:0003170 +xref: ZFA:0001580 is_a: UBERON:0011158 ! primary subdivision of skull relationship: BFO:0000050 UBERON:0003128 ! part of cranium relationship: protects UBERON:0000955 ! brain relationship: RO:0001015 UBERON:0000955 ! brain relationship: RO:0002202 UBERON:0004761 ! cartilaginous neurocranium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001708 name: jaw skeleton +def: "Subdivision of skeleton which includes upper and lower jaw skeletons." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Jaw] +xref: AAO:0000988 +xref: BTO:0001749 +xref: EMAPA:35455 +xref: FMA:54396 +xref: GAID:214 +xref: galen:Jaw +xref: MA:0001905 +xref: MESH:D007568 +xref: NCIT:C48821 +xref: SCTID:181811001 +xref: TAO:0001227 +xref: Wikipedia:Jaw +xref: ZFA:0001227 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton @@ -34097,9 +48052,46 @@ relationship: RO:0002160 NCBITaxon:7776 ! Gnathostomata relationship: RO:0002215 NBO:0000073 ! capable of relationship: RO:0002576 UBERON:0011595 ! jaw region +[Term] +id: UBERON:0001709 +name: upper jaw region +def: "Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Upper_jaw] +comment: See notes for jaw w.r.t skeletal element vs subdivision of head. +xref: AAO:0000620 +xref: EHDAA2:0002118 +xref: EHDAA2:0004607 +xref: EHDAA:8025 +xref: EMAPA:17924 +xref: FMA:59399 +xref: ncithesaurus:Upper_Jaw +xref: SCTID:362636001 +xref: VHOG:0000454 +xref: Wikipedia:Upper_jaw +is_a: UBERON:0000475 ! organism subdivision +is_a: UBERON:0010314 ! structure with developmental contribution from neural crest +intersection_of: UBERON:0000475 ! organism subdivision +intersection_of: RO:0002551 UBERON:0003277 ! skeleton of upper jaw +disjoint_from: UBERON:0001710 ! lower jaw region +relationship: BFO:0000050 UBERON:0004089 ! part of midface +relationship: BFO:0000050 UBERON:0011595 ! part of jaw region +relationship: RO:0002551 UBERON:0003277 ! skeleton of upper jaw + [Term] id: UBERON:0001710 name: lower jaw region +def: "Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]." [Wikipedia:Lower_jaw] +comment: See notes for jaw w.r.t skeletal element vs subdivision of head +xref: AAO:0000272 +xref: EFO:0003660 +xref: EHDAA2:0001018 +xref: EHDAA:7995 +xref: EMAPA:17906 +xref: FMA:59398 +xref: MESH:D008334 +xref: ncithesaurus:Lower_Jaw +xref: SCTID:362637005 +xref: VHOG:0000453 +xref: Wikipedia:Lower_jaw is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000475 ! organism subdivision @@ -34111,16 +48103,39 @@ relationship: RO:0002551 UBERON:0003278 ! skeleton of lower jaw [Term] id: UBERON:0001714 name: cranial ganglion +def: "The groups of nerve cell bodies associated with the twelve cranial nerves." [ISBN:0-683-40008-8, MGI:csmith, MP:0001081, PMID:9362461] +xref: BIRNLEX:2597 +xref: BTO:0000106 +xref: EFO:0000902 +xref: EMAPA:16659 +xref: FMA:54502 +xref: MA:0000213 +xref: MA:0000214 +xref: MAT:0000200 +xref: MIAA:0000200 +xref: SCTID:244448001 +xref: TAO:0000013 +xref: VHOG:0000076 +xref: Wikipedia:Cranial_nerve_ganglion +xref: XAO:0000027 +xref: ZFA:0000013 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0034713 ! cranial neuron projection bundle relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: extends_fibers_into UBERON:0034713 ! cranial neuron projection bundle -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001731 name: cavity of pharynx +def: "An anatomical space that is enclosed by a pharynx." [OBOL:automatic] +xref: AAO:0010435 +xref: BSA:0000113 +xref: BTO:0002097 +xref: EMAPA:18381 +xref: FMA:54935 +xref: SCTID:180543003 +xref: XAO:0000105 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0006562 ! pharynx @@ -34131,6 +48146,19 @@ relationship: RO:0002572 UBERON:0006562 ! pharynx [Term] id: UBERON:0001766 name: anterior chamber of eyeball +def: "The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens." [MESH:A09.371.060.067, MP:0005205] +xref: BTO:0002084 +xref: EHDAA2:0000129 +xref: EHDAA:9033 +xref: EMAPA:18231 +xref: FMA:58078 +xref: GAID:889 +xref: MA:0000262 +xref: MESH:D000867 +xref: NCIT:C12667 +xref: SCTID:181160009 +xref: VHOG:0001431 +xref: Wikipedia:Anterior_chamber_of_eyeball is_a: UBERON:0006311 ! chamber of eyeball relationship: BFO:0000050 UBERON:0001801 ! part of anterior segment of eyeball relationship: RO:0002433 UBERON:0001801 ! anterior segment of eyeball @@ -34138,6 +48166,16 @@ relationship: RO:0002433 UBERON:0001801 ! anterior segment of eyeball [Term] id: UBERON:0001768 name: uvea +def: "The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]." [MP:0005197, Wikipedia:Uvea] +xref: CALOHA:TS-2228 +xref: EMAPA:35901 +xref: FMA:58103 +xref: GAID:912 +xref: MA:0002480 +xref: MESH:D014602 +xref: NCIT:C12811 +xref: SCTID:280648000 +xref: Wikipedia:Uvea is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004923 ! organ component layer is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -34150,16 +48188,48 @@ relationship: RO:0002433 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0001769 name: iris +def: "The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye." [ISBN:0-683-40008-8, MP:0001322] +xref: AAO:0010347 +xref: BTO:0000653 +xref: CALOHA:TS-0491 +xref: EFO:0004245 +xref: EMAPA:19154 +xref: EV:0100345 +xref: FMA:58235 +xref: GAID:917 +xref: MA:0000273 +xref: MESH:D007498 +xref: NCIT:C12737 +xref: SCTID:181164000 +xref: TAO:0001238 +xref: VHOG:0000101 +xref: Wikipedia:Iris_(anatomy) +xref: XAO:0000185 +xref: ZFA:0001238 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0011892 ! part of anterior uvea relationship: RO:0002202 UBERON:0004128 ! optic vesicle relationship: RO:0002433 UBERON:0011892 ! anterior uvea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001772 name: corneal epithelium +def: "The smooth stratified squamous epithelium that covers the outer surface of the cornea." [MESH:A09.371.060.217.325, MGI:smb, MP:0006000] +xref: BTO:0000287 +xref: CALOHA:TS-0173 +xref: EFO:0001917 +xref: EHDAA2:0000319 +xref: EMAPA:17162 +xref: FMA:58263 +xref: GAID:895 +xref: MA:0001243 +xref: MESH:D019573 +xref: NCIT:C12928 +xref: SCTID:368825001 +xref: TAO:0002187 +xref: Wikipedia:Corneal_epithelium +xref: ZFA:0001683 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium @@ -34167,11 +48237,26 @@ intersection_of: RO:0002007 UBERON:0000964 ! bounding layer of cornea relationship: RO:0002007 UBERON:0000964 ! bounding layer of cornea relationship: RO:0002202 UBERON:0000076 ! external ectoderm relationship: RO:0002433 UBERON:0000964 ! cornea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001773 name: sclera +def: "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]." [Wikipedia:Sclera, ZFIN:ZDB-PUB-050701-15] +comment: Disease notes: implicated in rheumatoid arthritis. +xref: AAO:0010354 +xref: BTO:0001606 +xref: EMAPA:19027 +xref: EV:0100342 +xref: FMA:58269 +xref: GAID:911 +xref: MA:0000280 +xref: MESH:D012590 +xref: NCIT:C12784 +xref: SCTID:181163006 +xref: VHOG:0001274 +xref: Wikipedia:Sclera +xref: XAO:0000183 +xref: ZFA:0005563 is_a: UBERON:0000064 ! organ part is_a: UBERON:0010313 ! neural crest-derived structure relationship: BFO:0000050 UBERON:0012430 ! part of tunica fibrosa of eyeball @@ -34179,11 +48264,18 @@ relationship: BFO:0000051 CL:0000347 ! has part scleral cell relationship: RO:0000086 PATO:0000963 relationship: RO:0002202 UBERON:0003314 ! eye mesenchyme relationship: RO:0002433 UBERON:0000019 ! camera-type eye -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001774 name: skeletal muscle of trunk +def: "A skeletal muscle organ that is part of the trunk region." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000611 +xref: EMAPA:35888 +xref: FMA:58274 +xref: MA:0000514 +xref: TAO:0000473 +xref: XAO:0003230 +xref: ZFA:0000473 is_a: UBERON:0005177 ! trunk region element is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate @@ -34193,6 +48285,22 @@ relationship: BFO:0000050 UBERON:0004479 ! part of musculature of trunk [Term] id: UBERON:0001775 name: ciliary body +def: "The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes." [ISBN:0-683-40008-8, MP:0005099, Wikipedia:Ciliary_body] +xref: AAO:0010341 +xref: BTO:0000260 +xref: CALOHA:TS-0694 +xref: EMAPA:19065 +xref: EV:0100346 +xref: FMA:58295 +xref: GAID:916 +xref: MA:0000264 +xref: MESH:D002924 +xref: NCIT:C12345 +xref: neuronames:1571 +xref: SCTID:263340007 +xref: VHOG:0000102 +xref: Wikipedia:Ciliary_body +xref: XAO:0000186 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0011892 ! part of anterior uvea @@ -34200,11 +48308,25 @@ relationship: BFO:0000051 UBERON:0001605 ! has part ciliary muscle relationship: BFO:0000051 UBERON:0010427 ! has part ciliary processes relationship: RO:0002202 UBERON:0002346 ! neurectoderm relationship: RO:0002433 UBERON:0011892 ! anterior uvea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001776 name: optic choroid +def: "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]." [Wikipedia:Choroid] +xref: BTO:0001829 +xref: CALOHA:TS-2054 +xref: EMAPA:19077 +xref: EV:0100347 +xref: FMA:58298 +xref: GAID:913 +xref: MA:0000263 +xref: MESH:D002829 +xref: NCIT:C12344 +xref: SCTID:181172003 +xref: TAO:0005229 +xref: VHOG:0001568 +xref: Wikipedia:Choroid +xref: ZFA:0005229 is_a: UBERON:0002203 ! vasculature of eye relationship: BFO:0000050 UBERON:0001768 ! part of uvea relationship: BFO:0000050 UBERON:0019207 ! part of chorioretinal region @@ -34213,11 +48335,23 @@ relationship: RO:0002220 UBERON:0000966 ! adjacent to retina relationship: RO:0002220 UBERON:0001773 ! adjacent to sclera relationship: RO:0002220 UBERON:0011892 ! adjacent to anterior uvea relationship: RO:0002433 UBERON:0001768 ! uvea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001777 name: substantia propria of cornea +def: "The lamellated connective tissue of the cornea between the Bowman and Descemet membranes." [ISBN:0-683-40008-8, MESH:A09.371.060.217.228, MP:0005300] +xref: CALOHA:TS-1138 +xref: EFO:0002514 +xref: EMAPA:17602 +xref: FMA:58306 +xref: GAID:893 +xref: MA:0001245 +xref: MESH:D003319 +xref: NCIT:C12699 +xref: SCTID:362511000 +xref: TAO:0002189 +xref: Wikipedia:Corneal_stroma +xref: ZFA:0001685 is_a: UBERON:0003891 ! stroma is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0003891 ! stroma @@ -34231,6 +48365,15 @@ relationship: RO:0002433 UBERON:0000964 ! cornea [Term] id: UBERON:0001778 name: ciliary epithelium +def: "A double layer covering the ciliary body that produces aqueous humor." [Wikipedia:Ciliary_body#Ciliary_epithelium] +xref: BTO:0001770 +xref: CALOHA:TS-0695 +xref: EMAPA:35239 +xref: FMA:58464 +xref: MA:0001238 +xref: NCIT:C32314 +xref: SCTID:280870004 +xref: Wikipedia:Ciliary_body#Ciliary_epithelium is_a: UBERON:0000488 ! atypical epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium @@ -34238,11 +48381,17 @@ intersection_of: BFO:0000050 UBERON:0001775 ! part of ciliary body relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body relationship: BFO:0000051 GO:0048770 ! has part pigment granule relationship: RO:0003000 UBERON:0001796 ! produces aqueous humor of eyeball -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001779 name: iris stroma +def: "The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae." [http://www.drugs.com/dict/stroma-of-iris.html, Wikipedia:Iris_stroma] +xref: EMAPA:35451 +xref: FMA:58526 +xref: MA:0002777 +xref: SCTID:280882008 +xref: Wikipedia:Iris_stroma +xref: ZFA:0005569 is_a: UBERON:0003891 ! stroma is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0003891 ! stroma @@ -34253,15 +48402,38 @@ relationship: RO:0002433 UBERON:0001769 ! iris [Term] id: UBERON:0001780 name: spinal nerve +def: "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]." [MESH:A08.800.800.720, MP:0001077] +xref: AAO:0011101 +xref: BAMS:spin +xref: BTO:0000870 +xref: EHDAA2:0001898 +xref: EMAPA:16989 +xref: FMA:5858 +xref: GAID:841 +xref: MA:0000233 +xref: MESH:D013127 +xref: NCIT:C12792 +xref: neuronames:1228 +xref: SCTID:361099009 +xref: VHOG:0000824 +xref: Wikipedia:Spinal_nerve +xref: XAO:0003101 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: extends_fibers_into UBERON:0002240 ! spinal cord relationship: extends_fibers_into UBERON:0002240 ! spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001781 name: layer of retina +def: "Any of the layers that make up the retina[MP]." [MP:0003727] +xref: AAO:0010353 +xref: EMAPA:35742 +xref: FMA:58617 +xref: MA:0001319 +xref: NCIT:C49328 +xref: SCTID:280657006 +xref: XAO:0000266 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0022303 ! nervous system cell part layer relationship: BFO:0000050 UBERON:0000966 ! part of retina @@ -34270,6 +48442,27 @@ relationship: RO:0002433 UBERON:0000966 ! retina [Term] id: UBERON:0001785 name: cranial nerve +def: "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord." [Wikipedia:Cranial_nerve] +xref: AAO:0000108 +xref: BAMS:cran +xref: BIRNLEX:1623 +xref: BTO:0001104 +xref: EHDAA2:0000323 +xref: EMAPA:17264 +xref: FMA:5865 +xref: GAID:802 +xref: MA:0000215 +xref: MBA:967 +xref: MESH:D003391 +xref: NCIT:C12700 +xref: neuronames:1227 +xref: SCTID:244447006 +xref: TAO:0000641 +xref: VHOG:0000279 +xref: Wikipedia:Cranial_nerve +xref: XAO:0000429 +xref: XAO:0003089 +xref: ZFA:0000641 is_a: UBERON:0011779 ! nerve of head region is_a: UBERON:0034713 ! cranial neuron projection bundle intersection_of: UBERON:0001021 ! nerve @@ -34277,11 +48470,24 @@ intersection_of: BSPO:0000096 UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0000955 ! brain relationship: BSPO:0000096 UBERON:0001780 ! spinal nerve relationship: RO:0002254 UBERON:0003099 ! cranial neural crest -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001796 name: aqueous humor of eyeball +def: "A thick watery refractive medium that fills the space between the lens and the cornea[WP]." [Wikipedia:Aqueous_humor] +xref: EHDAA2:0000139 +xref: EHDAA:10196 +xref: EMAPA:18232 +xref: ENVO:02000024 +xref: FMA:58819 +xref: GAID:890 +xref: MA:0001236 +xref: MESH:D001082 +xref: NCIT:C13190 +xref: SCTID:280587006 +xref: VHOG:0000548 +xref: Wikipedia:Aqueous_humor +xref: ZFA:0005564 is_a: UBERON:0006312 ! ocular refractive media is_a: UBERON:0006314 ! bodily fluid relationship: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball @@ -34290,15 +48496,31 @@ relationship: RO:0002433 UBERON:0001766 ! anterior chamber of eyeball [Term] id: UBERON:0001800 name: sensory ganglion +def: "The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells." [MP:0000960] +xref: AEO:0001000 +xref: BTO:0005630 +xref: EMAPA:36596 +xref: FMA:5885 +xref: MA:0002566 +xref: MESH:D017950 +xref: NCIT:C13060 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: extends_fibers_into UBERON:0001027 ! sensory nerve relationship: extends_fibers_into UBERON:0001027 ! sensory nerve -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001801 name: anterior segment of eyeball +def: "Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive)." [ISBN:0-683-40008-8, MESH:A09.371.060, MP:0005193] +xref: EMAPA:36594 +xref: FMA:58865 +xref: MA:0002484 +xref: MESH:D000869 +xref: NCIT:C12668 +xref: SCTID:280658001 +xref: Wikipedia:Anterior_segment_of_eyeball +xref: ZFA:0005566 is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye @@ -34308,6 +48530,14 @@ relationship: RO:0002433 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0001802 name: posterior segment of eyeball +def: "Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive)." [ISBN:0-683-40008-8, MP:0005195] +xref: EMAPA:36595 +xref: FMA:58868 +xref: MA:0002485 +xref: NCIT:C12906 +xref: SCTID:280659009 +xref: Wikipedia:Posterior_segment_of_eyeball +xref: ZFA:0005567 is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye @@ -34317,17 +48547,37 @@ relationship: RO:0002433 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0001803 name: epithelium of lens +def: "A layer of epithelial cells that is part of the eye." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0001873 +xref: CALOHA:TS-0543 +xref: EMAPA:32871 +xref: FMA:58871 +xref: MA:0001301 +xref: SCTID:362523006 +xref: TAO:0001326 +xref: Wikipedia:Lens_(anatomy)#Lens_Epithelium +xref: XAO:0004094 +xref: ZFA:0001326 is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye relationship: RO:0002433 UBERON:0000965 ! lens of camera-type eye -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001804 name: capsule of lens +def: "The elastic, clear, membrane-like structure, that is outer most layer of the lens." [MGI:smb, MP:0003236, PMID:15483628] +xref: EHDAA2:0000977 +xref: EMAPA:18237 +xref: FMA:58881 +xref: MA:0001300 +xref: NCIT:C32975 +xref: SCTID:244500004 +xref: VHOG:0000550 +xref: Wikipedia:Lens_(anatomy)#Lens_capsule +xref: ZFA:0005574 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005764 ! acellular membrane intersection_of: UBERON:0000476 ! acellular anatomical structure @@ -34341,16 +48591,35 @@ relationship: RO:0002202 UBERON:0005614 ! lens anterior epithelium [Term] id: UBERON:0001805 name: autonomic ganglion +def: "Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion." [Wikipedia:Autonomic_ganglion] +xref: AEO:0001001 +xref: CALOHA:TS-2340 +xref: EMAPA:18221 +xref: FMA:5889 +xref: MA:0000220 +xref: MESH:D005725 +xref: NCIT:C12720 +xref: Wikipedia:Autonomic_ganglion is_a: UBERON:0003338 ! ganglion of peripheral nervous system intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: extends_fibers_into UBERON:0034728 ! autonomic nerve -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001806 name: sympathetic ganglion +def: "A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia." [http://orcid.org/0000-0002-6601-2165, MP:0001008] +xref: AAO:0010773 +xref: BTO:0001333 +xref: CALOHA:TS-0994 +xref: EHDAA2:0001969 +xref: EMAPA:17157 +xref: FMA:5890 +xref: MA:0000226 +xref: NCIT:C12467 +xref: SCTID:362485003 +xref: Wikipedia:Sympathetic_ganglion is_a: UBERON:0001805 ! autonomic ganglion is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0000045 ! ganglion @@ -34363,14 +48632,56 @@ relationship: RO:0002433 UBERON:0000013 ! sympathetic nervous system [Term] id: UBERON:0001833 name: lip +def: "One of the two fleshy folds which surround the opening of the mouth." [http://www.medterms.com/script/main/art.asp?articlekey=9458, Wikipedia:Lip] +xref: BTO:0001647 +xref: CALOHA:TS-0558 +xref: EMAPA:32839 +xref: FMA:59816 +xref: GAID:76 +xref: galen:Lip +xref: MA:0000343 +xref: MESH:D008046 +xref: NCIT:C12220 +xref: SCTID:181221003 +xref: TAO:0007006 +xref: VHOG:0000677 +xref: Wikipedia:Lip +xref: ZFA:0007006 is_a: UBERON:0003102 ! surface structure relationship: BFO:0000050 UBERON:0000165 ! part of mouth relationship: RO:0002221 UBERON:0000166 ! oral opening relationship: RO:0002433 UBERON:0000165 ! mouth +[Term] +id: UBERON:0001834 +name: upper lip +def: "Lip that covers the upper portion of the mouth.[TAO]." [TAO:0001970, Wikipedia:Upper_lip] +xref: EMAPA:17925 +xref: FMA:59817 +xref: MA:0000919 +xref: SCTID:245776003 +xref: TAO:0001970 +xref: VHOG:0001750 +xref: Wikipedia:Upper_lip +xref: ZFA:0005226 +is_a: UBERON:0001833 ! lip +intersection_of: UBERON:0001833 ! lip +intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: RO:0002495 UBERON:0011592 ! future upper lip + [Term] id: UBERON:0001835 name: lower lip +def: "Lip that covers the lower portion of the mouth.[TAO]." [TAO:0002060, Wikipedia:Lower_lip] +xref: EMAPA:17909 +xref: FMA:59818 +xref: MA:0000921 +xref: NCIT:C94572 +xref: SCTID:245777007 +xref: TAO:0002060 +xref: Wikipedia:Lower_lip +xref: ZFA:0005225 is_a: UBERON:0001833 ! lip intersection_of: UBERON:0001833 ! lip intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region @@ -34380,26 +48691,79 @@ relationship: RO:0002202 UBERON:0011596 ! future lower lip [Term] id: UBERON:0001884 name: phrenic nerve +def: "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium." [VHOG:0000728] +xref: BAMS:phn +xref: BTO:0001063 +xref: EHDAA:4677 +xref: EMAPA:17813 +xref: FMA:6191 +xref: GAID:848 +xref: MA:0001170 +xref: MESH:D010791 +xref: NCIT:C52813 +xref: SCTID:280344009 +xref: VHOG:0000728 +xref: Wikipedia:Phrenic_nerve is_a: UBERON:0003443 ! thoracic cavity nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001103 ! diaphragm relationship: RO:0002134 UBERON:0001103 ! diaphragm relationship: RO:0002380 UBERON:0000962 ! nerve of cervical vertebra -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001891 name: midbrain +def: "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]." [GO:0030901] +xref: AAO:0010149 +xref: BAMS:MES +xref: BIRNLEX:1667 +xref: BM:MB +xref: BTO:0000138 +xref: CALOHA:TS-0630 +xref: DHBA:10648 +xref: DMBA:16649 +xref: EFO:0000919 +xref: EHDAA2:0001162 +xref: EHDAA:3694 +xref: EMAPA:16974 +xref: EV:0100242 +xref: FMA:61993 +xref: HBA:9001 +xref: MA:0000207 +xref: MAT:0000106 +xref: MBA:313 +xref: MESH:D008636 +xref: MIAA:0000106 +xref: NCIT:C12510 +xref: RETIRED_EHDAA2:0001104 +xref: SCTID:279099009 +xref: TAO:0000128 +xref: VHOG:0000069 +xref: Wikipedia:Midbrain +xref: XAO:0000014 +xref: ZFA:0000128 is_a: UBERON:0002616 ! regional part of brain is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: RO:0002254 UBERON:0003849 ! mesencephalic neural crest relationship: RO:0002433 UBERON:0000955 ! brain relationship: RO:0002495 UBERON:0009616 ! presumptive midbrain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001892 name: rhombomere +def: "A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]." [Wikipedia:Rhombomere, ZFIN:curator] +xref: DHBA:12664 +xref: EFO:0003617 +xref: EMAPA:16148 +xref: FMA:295666 +xref: MAT:0000272 +xref: MIAA:0000272 +xref: RETIRED_EHDAA2:0000669 +xref: TAO:0001064 +xref: VHOG:0000672 +xref: Wikipedia:Rhombomere +xref: XAO:0004079 +xref: ZFA:0001064 is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: BFO:0000050 UBERON:0007277 ! part of presumptive hindbrain @@ -34408,6 +48772,24 @@ relationship: BFO:0000050 UBERON:0007277 ! part of presumptive hindbrain [Term] id: UBERON:0001895 name: metencephalon +def: "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Metencephalon] +comment: the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]. +xref: BAMS:Met +xref: BIRNLEX:965 +xref: BTO:0000673 +xref: CALOHA:TS-2029 +xref: DHBA:10655 +xref: EHDAA2:0001149 +xref: EHDAA:5498 +xref: EMAPA:17071 +xref: FMA:62003 +xref: GAID:594 +xref: HBA:4833 +xref: MA:0000197 +xref: MESH:D020540 +xref: NCIT:C32741 +xref: VHOG:0000741 +xref: Wikipedia:Metencephalon is_a: UBERON:0004733 ! segmental subdivision of hindbrain relationship: RO:0002433 UBERON:0002028 ! hindbrain relationship: RO:0002495 UBERON:0010092 ! future metencephalon @@ -34415,6 +48797,35 @@ relationship: RO:0002495 UBERON:0010092 ! future metencephalon [Term] id: UBERON:0001896 name: medulla oblongata +def: "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]." [FMA:62004, GO:0021550, Wikipedia:Bone_marrow_of_ovary_oblongata] +xref: AAO:0010486 +xref: BAMS:Md +xref: BAMS:MY +xref: BIRNLEX:957 +xref: BM:Me +xref: BTO:0000041 +xref: CALOHA:TS-0607 +xref: DMBA:17352 +xref: EFO:0000924 +xref: EHDAA2:0001088 +xref: EHDAA:7588 +xref: EMAPA:17550 +xref: EV:0100275 +xref: FMA:62004 +xref: GAID:590 +xref: MA:0000206 +xref: MAT:0000111 +xref: MAT:0000367 +xref: MBA:354 +xref: MESH:D008526 +xref: MIAA:0000111 +xref: NCIT:C12442 +xref: SCTID:279104005 +xref: TAO:0000545 +xref: VHOG:0000181 +xref: Wikipedia:Bone_marrow_of_ovary_oblongata +xref: XAO:0003100 +xref: ZFA:0000545 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0002298 ! part of brainstem @@ -34422,22 +48833,56 @@ relationship: BFO:0000050 UBERON:0005290 ! part of myelencephalon relationship: RO:0002215 GO:0002027 ! capable of regulation of heart rate relationship: RO:0002215 GO:0043576 ! capable of regulation of respiratory gaseous exchange relationship: RO:0002215 GO:0044058 ! capable of regulation of digestive system process -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001901 name: epithelium of trachea +def: "The epithelial lining of the trachea which contains numerous ciliated cells." [ISBN:0-397-51047-0, MGI:cwg, MP:0002285] +xref: BTO:0001389 +xref: CALOHA:TS-1061 +xref: EHDAA2:0002069 +xref: EHDAA:5007 +xref: EMAPA:16855 +xref: EMAPA:18409 +xref: FMA:62015 +xref: MA:0001862 +xref: NCIT:C33797 +xref: VHOG:0001045 is_a: UBERON:0008397 ! tracheobronchial epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 UBERON:0003258 ! endoderm of foregut relationship: RO:0002433 UBERON:0003126 ! trachea -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001902 +name: epithelium of small intestine +def: "An epithelium that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001258 +xref: CALOHA:TS-2104 +xref: EMAPA:35778 +xref: FMA:62017 +xref: MA:0001553 +xref: SCTID:45480009 +xref: TAO:0005127 +xref: ZFA:0005127 +is_a: UBERON:0001277 ! intestinal epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001204 ! part of mucosa of small intestine +relationship: BFO:0000051 CL:0000164 ! has part enteroendocrine cell [Term] id: UBERON:0001915 name: endothelium of capillary +def: "An endothelium that is part of a capillary [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004954 +xref: CALOHA:TS-0112 +xref: EMAPA:36292 +xref: FMA:62114 +xref: MA:0000711 +xref: NCIT:C49215 is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001982 ! part of capillary @@ -34446,6 +48891,11 @@ relationship: BFO:0000050 UBERON:0001982 ! part of capillary [Term] id: UBERON:0001916 name: endothelium of arteriole +def: "An endothelium that is part of an arteriole [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36286 +xref: FMA:62115 +xref: MA:0000705 +xref: NCIT:C49192 is_a: UBERON:0004700 ! arterial system endothelium is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium @@ -34455,6 +48905,15 @@ relationship: BFO:0000050 UBERON:0001980 ! part of arteriole [Term] id: UBERON:0001917 name: endothelium of artery +def: "An endothelium that is part of an artery [Automatically generated definition]." [OBOL:automatic] +xref: AAO:0011013 +xref: BTO:0004757 +xref: EMAPA:35148 +xref: FMA:62116 +xref: MA:0000707 +xref: NCIT:C49194 +xref: VHOG:0001215 +xref: XAO:0000357 is_a: UBERON:0003915 ! endothelial tube is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004700 ! arterial system endothelium @@ -34465,6 +48924,11 @@ relationship: BFO:0000050 UBERON:0001637 ! part of artery [Term] id: UBERON:0001918 name: endothelium of venule +def: "An endothelium that is part of a venule [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36290 +xref: FMA:62117 +xref: MA:0000716 +xref: NCIT:C49319 is_a: UBERON:0004701 ! venous system endothelium is_a: UBERON:0008339 ! microvascular endothelium intersection_of: UBERON:0001986 ! endothelium @@ -34474,6 +48938,15 @@ relationship: BFO:0000050 UBERON:0001979 ! part of venule [Term] id: UBERON:0001919 name: endothelium of vein +def: "An endothelium that is part of a vein [Automatically generated definition]." [OBOL:automatic] +xref: AAO:0011110 +xref: BTO:0004756 +xref: EMAPA:36288 +xref: FMA:62118 +xref: MA:0000712 +xref: NCIT:C49317 +xref: VHOG:0001216 +xref: XAO:0000358 is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004701 ! venous system endothelium intersection_of: UBERON:0001986 ! endothelium @@ -34483,15 +48956,37 @@ relationship: BFO:0000050 UBERON:0001638 ! part of vein [Term] id: UBERON:0001943 name: midbrain tegmentum +def: "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]." [FMA:FMA, ISBN:0471888893, Wikipedia:Midbrain_tegmentum] +comment: 'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum +xref: BAMS:MTg +xref: BIRNLEX:1200 +xref: BTO:0003388 +xref: DHBA:12195 +xref: EFO:0000921 +xref: EHDAA2:0004475 +xref: EMAPA:18215 +xref: FMA:62393 +xref: HBA:9002 +xref: MA:0000212 +xref: MAT:0000452 +xref: SCTID:362392007 +xref: TAO:0000160 +xref: VHOG:0001367 +xref: Wikipedia:Midbrain_tegmentum +xref: XAO:0004271 +xref: ZFA:0000160 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: BFO:0000050 UBERON:0002298 ! part of brainstem relationship: RO:0002202 UBERON:0010285 ! midbrain basal plate -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001948 name: regional part of spinal cord +def: "A multi-tissue structure that is part of a spinal cord." [OBOL:automatic] +xref: BIRNLEX:1496 +xref: NCIT:C33969 +xref: SCTID:244437008 is_a: UBERON:0000073 ! regional part of nervous system is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000481 ! multi-tissue structure @@ -34501,15 +48996,25 @@ relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord [Term] id: UBERON:0001955 name: epithelium of respiratory bronchiole +def: "An epithelium that is part of a respiratory bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35730 +xref: FMA:62498 +xref: MA:0001773 +xref: NCIT:C48943 is_a: UBERON:0002051 ! epithelium of bronchiole intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole relationship: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001956 name: cartilage of bronchus +def: "The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]." [MP:0010988] +xref: EMAPA:35192 +xref: FMA:62649 +xref: MA:0001835 +xref: NCIT:C49209 +xref: SCTID:278980009 is_a: UBERON:0003603 ! lower respiratory tract cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus @@ -34517,11 +49022,16 @@ relationship: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000051 CL:0019002 ! has part tracheobronchial chondrocyte relationship: RO:0002433 UBERON:0002185 ! bronchus relationship: RO:0002473 UBERON:0001994 ! hyaline cartilage tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001957 name: submucosa of bronchus +def: "A submucosa that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0002108 +xref: FMA:62653 +xref: MA:0001837 +xref: NCIT:C49214 +xref: SCTID:85546005 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa @@ -34531,15 +49041,32 @@ relationship: BFO:0000050 UBERON:0002185 ! part of bronchus [Term] id: UBERON:0001958 name: terminal bronchiole epithelium +def: "An epithelium that lines a terminal bronchiole." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:36283 +xref: FMA:62794 +xref: MA:0001774 +xref: NCIT:C33755 is_a: UBERON:0002051 ! epithelium of bronchiole intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole relationship: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001969 name: blood plasma +def: "The liquid component of blood, in which erythrocytes are suspended." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000131 +xref: CALOHA:TS-0800 +xref: EFO:0001905 +xref: EMAPA:35690 +xref: FMA:62970 +xref: GAID:1178 +xref: MA:0002501 +xref: MAT:0000052 +xref: MESH:D010949 +xref: MIAA:0000052 +xref: NCIT:C13356 +xref: Wikipedia:Blood_plasma is_a: UBERON:0000179 ! haemolymphatic fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: BFO:0000050 UBERON:0000178 ! part of blood @@ -34550,9 +49077,43 @@ relationship: BFO:0000050 UBERON:0000178 ! part of blood relationship: BFO:0000051 GO:0005577 ! has part fibrinogen complex relationship: RO:0002221 CL:0000232 ! erythrocyte +[Term] +id: UBERON:0001970 +name: bile +def: "Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium." [DOI:10.1002/cphy.c120027, Wikipedia:Bile] +xref: BTO:0000121 +xref: CALOHA:TS-1172 +xref: ENVO:02000023 +xref: FMA:62971 +xref: GAID:1157 +xref: galen:Bile +xref: MA:0002513 +xref: MESH:D001646 +xref: NCIT:C13192 +xref: Wikipedia:Bile +xref: ZFA:0005857 +is_a: UBERON:0000456 ! secretion of exocrine gland +is_a: UBERON:0006314 ! bodily fluid +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: RO:0003001 UBERON:0002107 ! produced by liver +relationship: BFO:0000051 CHEBI:16990 ! has part +relationship: BFO:0000051 CHEBI:22868 ! has part +relationship: BFO:0000051 CHEBI:36277 ! has part +relationship: RO:0000086 PATO:0001735 +relationship: RO:0002216 GO:0007586 ! capable of part of digestion +relationship: RO:0003001 UBERON:0002107 ! produced by liver + [Term] id: UBERON:0001971 name: gastric juice +xref: BTO:0000501 +xref: FMA:62972 +xref: GAID:1160 +xref: galen:GastricJuice +xref: MA:0002519 +xref: MESH:D005750 +xref: NCIT:C32661 +xref: Wikipedia:Gastric_juice is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: RO:0003001 UBERON:0011953 ! produced by stomach glandular region @@ -34561,6 +49122,12 @@ relationship: RO:0003001 UBERON:0011953 ! produced by stomach glandular region [Term] id: UBERON:0001972 name: submucosa of esophagus +def: "A submucosa that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0002109 +xref: EMAPA:35325 +xref: FMA:62997 +xref: MA:0002724 +xref: SCTID:362128009 is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -34569,6 +49136,11 @@ relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus [Term] id: UBERON:0001974 name: lamina propria of esophagus +def: "A lamina propria that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:26987 +xref: FMA:63050 +xref: MA:0001568 +xref: NCIT:C49223 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -34577,6 +49149,10 @@ relationship: BFO:0000050 UBERON:0002469 ! part of esophagus mucosa [Term] id: UBERON:0001975 name: serosa of esophagus +def: "A serous membrane that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35322 +xref: FMA:63057 +xref: MA:0001571 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -34585,6 +49161,17 @@ relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus [Term] id: UBERON:0001976 name: epithelium of esophagus +def: "The epithelial layer that lines the luminal space of the esophagus." [ISBN:0-683-40008-8, MP:0000468] +xref: BTO:0001578 +xref: CALOHA:TS-0698 +xref: EFO:0003041 +xref: EHDAA2:0001287 +xref: EMAPA:16835 +xref: FMA:63063 +xref: MA:0001565 +xref: NCIT:C49221 +xref: TAO:0001499 +xref: ZFA:0001499 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium @@ -34592,18 +49179,55 @@ intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0002469 ! part of esophagus mucosa relationship: RO:0002433 UBERON:0001043 ! esophagus +[Term] +id: UBERON:0001978 +name: parenchyma of pancreas +xref: EMAPA:32925 +xref: FMA:63120 +xref: MA:0000724 +xref: SCTID:371401008 +xref: VHOG:0001430 +is_a: UBERON:0000353 ! parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: UBERON:0001979 name: venule +def: "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins." [MESH:A07.231.432.952, MP:0004125] +xref: BTO:0002626 +xref: EMAPA:35917 +xref: FMA:63130 +xref: MA:0000071 +xref: MESH:D014699 +xref: NCIT:C12818 +xref: SCTID:341687009 +xref: TAO:0005315 +xref: VHOG:0001765 +xref: Wikipedia:Venule +xref: ZFA:0005315 is_a: UBERON:0003920 ! venous blood vessel is_a: UBERON:8410081 ! blood microvessel relationship: RO:0002176 UBERON:0001638 ! vein relationship: RO:0002176 UBERON:0001982 ! capillary -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001980 name: arteriole +def: "The smallest division of the artery located between the muscular arteries and the capillaries[GO]." [GO:0014830] +xref: AAO:0010253 +xref: BTO:0001997 +xref: EMAPA:35146 +xref: FMA:63182 +xref: MA:0000063 +xref: MESH:D001160 +xref: NCIT:C12672 +xref: SCTID:337724002 +xref: TAO:0002138 +xref: VHOG:0001763 +xref: Wikipedia:Arteriole +xref: ZFA:0005255 is_a: UBERON:0003509 ! arterial blood vessel is_a: UBERON:8410081 ! blood microvessel intersection_of: UBERON:0001981 ! blood vessel @@ -34616,6 +49240,30 @@ relationship: RO:0002433 UBERON:0001637 ! artery [Term] id: UBERON:0001981 name: blood vessel +def: "A vessel through which blood circulates in the body." [BTO:0001102, Wikipedia:Blood_vessel] +xref: AAO:0011004 +xref: AEO:0000207 +xref: BTO:0001102 +xref: CALOHA:TS-0080 +xref: EFO:0000817 +xref: EHDAA2:0003252 +xref: EHDAA:240 +xref: EMAPA:32743 +xref: EMAPA:35993 +xref: FMA:50722 +xref: FMA:63183 +xref: GAID:169 +xref: MA:0000060 +xref: MAT:0000393 +xref: MESH:D001808 +xref: NCIT:C12679 +xref: NLXANAT:090901 +xref: SCTID:361097006 +xref: TAO:0002137 +xref: VHOG:0001250 +xref: Wikipedia:Blood_vessel +xref: XAO:0001011 +xref: ZFA:0005314 is_a: UBERON:0000055 ! vessel is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0004537 ! part of blood vasculature @@ -34626,22 +49274,49 @@ relationship: RO:0000086 PATO:0002045 relationship: RO:0002202 UBERON:0004872 ! splanchnic layer of lateral plate mesoderm relationship: RO:0002202 UBERON:0006965 ! vascular cord relationship: RO:0002216 GO:0008015 ! capable of part of blood circulation -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001982 name: capillary +def: "Any of the smallest blood vessels connecting arterioles with venules." [https://github.com/obophenotype/uberon/issues/137, ISBN:0073040584, Wikipedia:Capillary] +xref: AAO:0010252 +xref: BTO:0002045 +xref: CALOHA:TS-2006 +xref: EFO:0001906 +xref: EMAPA:35198 +xref: EV:0100035 +xref: FMA:63194 +xref: MA:0000065 +xref: MESH:D002196 +xref: NCIT:C12685 +xref: NLXANAT:090902 +xref: TAO:0005250 +xref: VHOG:0001253 +xref: Wikipedia:Capillary +xref: XAO:0000116 +xref: ZFA:0005250 is_a: UBERON:8410081 ! blood microvessel intersection_of: UBERON:8410081 ! blood microvessel intersection_of: RO:0002176 UBERON:0001979 ! venule intersection_of: RO:0002176 UBERON:0001980 ! arteriole relationship: RO:0002176 UBERON:0001979 ! venule relationship: RO:0002176 UBERON:0001980 ! arteriole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001985 name: corneal endothelium +def: "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]." [Wikipedia:Corneal_endothelium] +xref: CALOHA:TS-0172 +xref: EMAPA:35935 +xref: FMA:63882 +xref: GAID:891 +xref: MA:0001242 +xref: MESH:D004728 +xref: NCIT:C12707 +xref: SCTID:368827009 +xref: TAO:0002186 +xref: Wikipedia:Corneal_endothelium +xref: ZFA:0001687 is_a: UBERON:0001986 ! endothelium is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0015808 ! eye epithelium @@ -34650,28 +49325,85 @@ intersection_of: BFO:0000050 UBERON:0000964 ! part of cornea relationship: BFO:0000050 UBERON:0000964 ! part of cornea relationship: RO:0002220 UBERON:0001766 ! adjacent to anterior chamber of eyeball relationship: RO:0002433 UBERON:0000964 ! cornea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0001986 name: endothelium +def: "A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]." [FMA:63916, https://github.com/obophenotype/uberon/issues/225, MESH:A10.272.491] +comment: The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980) +xref: BTO:0000393 +xref: CALOHA:TS-0278 +xref: EFO:0002548 +xref: FMA:63916 +xref: GAID:520 +xref: galen:Endothelium +xref: MESH:D004727 +xref: NCIT:C12481 +xref: SCTID:27168002 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0012275 ! meso-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002473 CL:0000115 ! endothelial cell relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002473 CL:0000115 ! endothelial cell -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0001988 +name: feces +def: "Portion of semisolid bodily waste discharged through the anus[MW,modified]." [http://www.merriam-webster.com/dictionary/feces, Wikipedia:Feces] +xref: BTO:0000440 +xref: CALOHA:TS-2345 +xref: ENVO:00002003 +xref: FMA:64183 +xref: GAID:1199 +xref: galen:Feces +xref: MA:0002509 +xref: MAT:0000053 +xref: MESH:D005243 +xref: MIAA:0000053 +xref: NCIT:C13234 +xref: Wikipedia:Feces +is_a: UBERON:0000174 ! excreta +intersection_of: UBERON:0000174 ! excreta +intersection_of: RO:0002353 GO:0030421 ! output of defecation +relationship: RO:0002353 GO:0030421 ! output of defecation [Term] id: UBERON:0001994 name: hyaline cartilage tissue +def: "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000094] +xref: EMAPA:35414 +xref: FMA:64783 +xref: MA:0000109 +xref: NCIT:C32746 +xref: SCTID:39298000 +xref: VSAO:0000094 +xref: Wikipedia:Hyaline_cartilage +xref: XAO:0004029 is_a: UBERON:0002418 ! cartilage tissue relationship: RO:0002473 GO:0005585 ! collagen type II trimer [Term] id: UBERON:0002012 name: pulmonary artery +def: "An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Pulmonary_artery] +xref: AAO:0010221 +xref: BTO:0000778 +xref: CALOHA:TS-0839 +xref: EFO:0001399 +xref: EHDAA2:0001575 +xref: EHDAA:4351 +xref: EMAPA:17008 +xref: FMA:66326 +xref: GAID:505 +xref: galen:PulmonaryArtery +xref: MA:0002031 +xref: MESH:D011651 +xref: NCIT:C12774 +xref: SCTID:181380003 +xref: VHOG:0000982 +xref: Wikipedia:Pulmonary_artery +xref: XAO:0004162 is_a: UBERON:0001637 ! artery is_a: UBERON:0013768 ! great vessel of heart intersection_of: UBERON:0001637 ! artery @@ -34684,11 +49416,27 @@ relationship: RO:0002178 UBERON:0002048 ! lung relationship: RO:0002202 UBERON:0002061 ! truncus arteriosus relationship: RO:0002202 UBERON:0003123 ! pharyngeal arch artery 6 relationship: RO:0002202 UBERON:0005339 ! outflow tract pulmonary component -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002016 name: pulmonary vein +def: "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]." [GO:0060577] +xref: AAO:0010521 +xref: BTO:0001799 +xref: CALOHA:TS-0840 +xref: EHDAA2:0001579 +xref: EHDAA:2629 +xref: EMAPA:18645 +xref: FMA:66643 +xref: GAID:543 +xref: galen:PulmonaryVein +xref: MA:0002206 +xref: MESH:D011667 +xref: NCIT:C12776 +xref: SCTID:430160002 +xref: VHOG:0001133 +xref: Wikipedia:Pulmonary_vein +xref: XAO:0000394 is_a: UBERON:0001638 ! vein is_a: UBERON:0013768 ! great vessel of heart intersection_of: UBERON:0001638 ! vein @@ -34697,27 +49445,111 @@ relationship: BFO:0000050 UBERON:0008886 ! part of pulmonary vascular system relationship: RO:0002170 UBERON:0002079 ! left cardiac atrium relationship: RO:0002179 UBERON:0002048 ! lung relationship: RO:0002202 UBERON:0002061 ! truncus arteriosus -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002017 +name: portal vein +def: "A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]." [BTO:0001792] +xref: BTO:0001792 +xref: CALOHA:TS-0814 +xref: EHDAA2:0001485 +xref: EHDAA:6510 +xref: EMAPA:17349 +xref: FMA:66645 +xref: GAID:540 +xref: galen:PortalVein +xref: MA:0002198 +xref: MESH:D011169 +xref: NCIT:C33343 +xref: SCTID:362064007 +xref: VHOG:0000656 +xref: XAO:0000392 +is_a: UBERON:0001638 ! vein +relationship: BFO:0000050 UBERON:0005806 ! part of portal system [Term] id: UBERON:0002020 name: gray matter +def: "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Gray_matter] +xref: AEO:0001012 +xref: EHDAA2:0003136 +xref: EHDAA2_RETIRED:0004658 +xref: FMA:67242 +xref: HBA:4006 +xref: MA:0001112 +xref: NCIT:C32695 +xref: neuronames:2869 +xref: TAO:0002197 +xref: VHOG:0001768 +xref: Wikipedia:Gray_matter +xref: ZFA:0001681 is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: RO:0002473 GO:0043025 ! neuronal cell body [Term] id: UBERON:0002028 name: hindbrain +def: "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]." [Wikipedia:Rhombencephalon, ZFA:0000029, ZFIN:curator] +xref: AAO:0010150 +xref: BAMS:HB +xref: BIRNLEX:942 +xref: BTO:0000672 +xref: CALOHA:TS-0457 +xref: DHBA:10653 +xref: DMBA:16808 +xref: EFO:0000923 +xref: EHDAA2:0000746 +xref: EHDAA:3514 +xref: EHDAA:6487 +xref: EMAPA:16916 +xref: FMA:67687 +xref: MA:0000195 +xref: MAT:0000107 +xref: MBA:1065 +xref: MESH:D012249 +xref: MIAA:0000107 +xref: NCIT:C40336 +xref: SCTID:303456008 +xref: TAO:0000029 +xref: VHOG:0000070 +xref: Wikipedia:Rhombencephalon +xref: XAO:0000015 +xref: ZFA:0000029 is_a: UBERON:0002616 ! regional part of brain relationship: RO:0002131 UBERON:0002298 ! overlaps brainstem relationship: RO:0002160 NCBITaxon:89593 ! Craniata relationship: RO:0002433 UBERON:0000955 ! brain relationship: RO:0002495 UBERON:0007277 ! presumptive hindbrain -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002029 +name: epithelium of gall bladder +def: "The simple columnar epithelial lining of the gall bladder." [MP:0009492] +xref: BTO:0001449 +xref: CALOHA:TS-1304 +xref: EMAPA:35370 +xref: FMA:67711 +xref: MA:0001632 +xref: NCIT:C49227 +is_a: UBERON:0000485 ! simple columnar epithelium +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0034932 ! epithelium of biliary system +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: RO:0002433 UBERON:0002110 ! gallbladder [Term] id: UBERON:0002031 name: epithelium of bronchus +def: "An epithelium that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001845 +xref: CALOHA:TS-1240 +xref: EFO:0000307 +xref: EMAPA:32691 +xref: FMA:67782 +xref: MA:0001839 +xref: NCIT:C32231 is_a: UBERON:0008397 ! tracheobronchial epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus @@ -34728,6 +49560,18 @@ relationship: RO:0002433 UBERON:0002185 ! bronchus [Term] id: UBERON:0002036 name: striated muscle tissue +def: "Muscle tissue that contains fibers that are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_muscle] +xref: AAO:0010762 +xref: AEO:0000140 +xref: CALOHA:TS-2047 +xref: EHDAA2:0003140 +xref: EMAPA:36390 +xref: FMA:67905 +xref: galen:StriatedMuscle +xref: MA:0002438 +xref: NCIT:C12436 +xref: WBbt:0005779 +xref: Wikipedia:Striated_muscle is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: RO:0002473 CL:0000737 ! striated muscle cell @@ -34736,6 +49580,16 @@ relationship: RO:0002473 CL:0000737 ! striated muscle cell [Term] id: UBERON:0002040 name: bronchial artery +def: "A systemic artery that supplies the lung with with oxygenated blood." [UBERON:cjm, Wikipedia:Bronchial_artery] +comment: Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung. +xref: EMAPA:18608 +xref: FMA:68109 +xref: GAID:477 +xref: MA:0001923 +xref: MESH:D001981 +xref: NCIT:C32230 +xref: SCTID:244247009 +xref: Wikipedia:Bronchial_artery is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0004573 ! systemic artery intersection_of: BFO:0000050 UBERON:0004571 ! part of systemic arterial system @@ -34743,11 +49597,22 @@ intersection_of: RO:0002178 UBERON:0002048 ! lung relationship: BFO:0000051 UBERON:0004848 ! has part respiratory system arterial endothelium relationship: BFO:0000051 UBERON:0012416 ! has part respiratory system arterial smooth muscle relationship: RO:0002178 UBERON:0002048 ! lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002047 name: pontine raphe nucleus +def: "The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]." [Wikipedia:Pontine_raphe_nucleus] +xref: BAMS:PnR +xref: BAMS:RA-PONS +xref: BAMS:RPn +xref: BIRNLEX:1110 +xref: DHBA:12471 +xref: DHBA:12475 +xref: FMA:68875 +xref: HBA:9159 +xref: MA:0001022 +xref: MBA:238 +xref: Wikipedia:Pontine_raphe_nucleus is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus relationship: BFO:0000050 UBERON:0003023 ! part of pontine tegmentum @@ -34756,6 +49621,29 @@ relationship: BFO:0000050 UBERON:0004684 ! part of raphe nuclei [Term] id: UBERON:0002048 name: lung +def: "Respiration organ that develops as an outpocketing of the esophagus." [http://orcid.org/0000-0002-6601-2165] +comment: Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP] +xref: AAO:0000275 +xref: AAO:0010567 +xref: BTO:0000763 +xref: CALOHA:TS-0568 +xref: EFO:0000934 +xref: EHDAA2:0001042 +xref: EHDAA:1554 +xref: EHDAA:2205 +xref: EMAPA:16728 +xref: EV:0100042 +xref: FMA:7195 +xref: GAID:345 +xref: galen:Lung +xref: MA:0000415 +xref: MAT:0000135 +xref: MESH:D008168 +xref: MIAA:0000135 +xref: NCIT:C12468 +xref: SCTID:181216001 +xref: Wikipedia:Lung +xref: XAO:0000119 is_a: UBERON:0000171 ! respiration organ is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005178 ! thoracic cavity element @@ -34765,20 +49653,39 @@ relationship: BSPO:0000126 UBERON:0000170 ! pair of lungs relationship: RO:0002160 NCBITaxon:7776 ! Gnathostomata relationship: RO:0002202 UBERON:0000118 ! lung bud relationship: RO:0002433 UBERON:0001004 ! respiratory system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002049 name: vasculature +def: "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face." [ZFA:0005249] +xref: BTO:0003718 +xref: FMA:69050 +xref: TAO:0005249 +xref: ZFA:0005249 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0007798 ! part of vascular system relationship: BFO:0000051 UBERON:0000179 ! has part haemolymphatic fluid relationship: RO:0002473 UBERON:0000055 ! vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002050 name: embryonic structure +def: "Anatomical structure that is part of an embryo." [BTO:0000174, ZFIN:curator] +xref: AAO:0000138 +xref: BILA:0000034 +xref: BTO:0000174 +xref: CALOHA:TS-2110 +xref: EFO:0000461 +xref: FMA:69067 +xref: GAID:407 +xref: MESH:D004628 +xref: NCIT:C13229 +xref: RETIRED_EHDAA2:0003169 +xref: SCTID:667009 +xref: TAO:0001105 +xref: VSAO:0000178 +xref: XAO:0003042 +xref: ZFA:0001105 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -34787,6 +49694,13 @@ relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: UBERON:0002051 name: epithelium of bronchiole +def: "An epithelium that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001866 +xref: CALOHA:TS-0570 +xref: EMAPA:32693 +xref: FMA:69077 +xref: MA:0001772 +xref: NCIT:C48942 is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0008397 ! tracheobronchial epithelium @@ -34797,11 +49711,14 @@ relationship: BFO:0000051 CL:0000158 ! has part club cell relationship: BFO:0000051 CL:0002145 ! has part ciliated columnar cell of tracheobronchial tree relationship: BFO:0000051 CL:1000271 ! has part lung ciliated cell relationship: RO:0002433 UBERON:0002186 ! bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002057 name: phrenic artery +def: "An artery that supplies the diaphragm." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:69330 +xref: MA:0002019 +xref: NCIT:C33320 is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0004573 ! systemic artery intersection_of: RO:0002178 UBERON:0001103 ! diaphragm @@ -34810,6 +49727,16 @@ relationship: RO:0002178 UBERON:0001103 ! diaphragm [Term] id: UBERON:0002061 name: truncus arteriosus +def: "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles." [Wikipedia:Truncus_arteriosus_(embryology)] +xref: EHDAA2:0004143 +xref: EMAPA:35887 +xref: FMA:70301 +xref: GAID:554 +xref: MA:0000103 +xref: MESH:D014338 +xref: NCIT:C34317 +xref: SCTID:308828009 +xref: Wikipedia:Truncus_arteriosus_(embryology) is_a: UBERON:0001637 ! artery is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003498 ! heart blood vessel @@ -34820,6 +49747,19 @@ relationship: RO:0002202 UBERON:0005432 ! aortic sac [Term] id: UBERON:0002062 name: endocardial cushion +def: "The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]." [GO:0003197, Wikipedia:Atrioventricular_cushions, ZFIN:curator] +comment: GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form +xref: EHDAA2:0000434 +xref: EHDAA2:0004028 +xref: EHDAA:2586 +xref: EMAPA:16696 +xref: FMA:70302 +xref: MA:0000078 +xref: TAO:0001317 +xref: VHOG:0000932 +xref: Wikipedia:Atrioventricular_cushions +xref: XAO:0004189 +xref: ZFA:0001317 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0009751 ! cardiac mesenchyme @@ -34829,6 +49769,18 @@ relationship: BFO:0000050 UBERON:0002165 ! part of endocardium [Term] id: UBERON:0002063 name: sinus venosus +def: "The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart." [PMID:20735616, Wikipedia:Sinus_venosus] +xref: AAO:0010505 +xref: EHDAA2:0001839 +xref: EHDAA:480 +xref: EMAPA:16237 +xref: FMA:70303 +xref: NCIT:C34299 +xref: NCIT:C34300 +xref: TAO:0000154 +xref: VHOG:0000177 +xref: Wikipedia:Sinus_venosus +xref: ZFA:0000154 is_a: UBERON:0004151 ! cardiac chamber relationship: BFO:0000050 UBERON:0002350 ! part of conducting system of heart relationship: RO:0002495 UBERON:0007278 ! presumptive sinus venosus @@ -34836,6 +49788,26 @@ relationship: RO:0002495 UBERON:0007278 ! presumptive sinus venosus [Term] id: UBERON:0002067 name: dermis +def: "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]." [Wikipedia:Dermis, ZFIN:curator] +xref: AAO:0000128 +xref: BTO:0000294 +xref: CALOHA:TS-2076 +xref: EFO:0000953 +xref: EMAPA:17527 +xref: EV:0100154 +xref: FMA:70323 +xref: GAID:1321 +xref: MA:0000152 +xref: MAT:0000153 +xref: MESH:D020405 +xref: MIAA:0000153 +xref: NCIT:C12701 +xref: SCTID:361696001 +xref: TAO:0001119 +xref: VHOG:0000108 +xref: Wikipedia:Dermis +xref: XAO:0000217 +xref: ZFA:0001119 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0013754 ! integumentary system layer @@ -34846,11 +49818,18 @@ relationship: BSPO:0000107 UBERON:0001003 ! skin epidermis relationship: BSPO:0000108 UBERON:0002072 ! hypodermis relationship: RO:0002473 UBERON:0002384 ! connective tissue relationship: RO:0002495 UBERON:0010083 ! future dermis -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002072 name: hypodermis +def: "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]." [Wikipedia:Hypodermis] +xref: BTO:0001314 +xref: CALOHA:TS-2366 +xref: FMA:70544 +xref: NCIT:C33645 +xref: TAO:0001136 +xref: Wikipedia:Hypodermis +xref: ZFA:0001136 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013754 ! integumentary system layer relationship: BFO:0000050 UBERON:0002199 ! part of integument @@ -34858,11 +49837,23 @@ relationship: BSPO:0000107 UBERON:0002067 ! dermis relationship: BSPO:0000108 UBERON:0001015 ! musculature relationship: RO:0002473 UBERON:0001013 ! adipose tissue relationship: RO:0002473 UBERON:0011825 ! loose connective tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002075 name: viscus +def: "An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen." [BTO:0001491, https://github.com/obophenotype/mouse-anatomy-ontology/issues/14, Wikipedia:Viscus] +xref: AAO:0010386 +xref: BTO:0001491 +xref: EHDAA:512 +xref: EMAPA:16245 +xref: FMA:7085 +xref: MA:0000019 +xref: MESH:D014781 +xref: NCIT:C28287 +xref: RETIRED_EHDAA2:0002201 +xref: SCTID:118760003 +xref: Wikipedia:Viscus +xref: XAO:0003034 is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0000062 ! organ intersection_of: RO:0001025 UBERON:0002323 ! coelemic cavity lumen @@ -34871,26 +49862,62 @@ relationship: RO:0001025 UBERON:0002323 ! coelemic cavity lumen [Term] id: UBERON:0002078 name: right cardiac atrium +def: "A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Right_atrium] +xref: AAO:0010248 +xref: BTO:0001703 +xref: EHDAA2:0000290 +xref: EMAPA:17321 +xref: FMA:7096 +xref: galen:RightAtrium +xref: MA:0000075 +xref: NCIT:C12868 +xref: SCTID:244383003 +xref: VHOG:0000328 +xref: Wikipedia:Right_atrium +xref: XAO:0003192 is_a: UBERON:0002081 ! cardiac atrium is_a: UBERON:0035554 ! right cardiac chamber intersection_of: UBERON:0002081 ! cardiac atrium intersection_of: BSPO:0000121 UBERON:0000948 ! heart relationship: RO:0002170 UBERON:0004537 ! blood vasculature -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002079 name: left cardiac atrium +def: "A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Left_atrium] +xref: AAO:0010247 +xref: BTO:0001702 +xref: EHDAA2:0000275 +xref: EMAPA:17315 +xref: FMA:7097 +xref: galen:LeftAtrium +xref: MA:0000074 +xref: NCIT:C12869 +xref: SCTID:244387002 +xref: VHOG:0000369 +xref: Wikipedia:Left_atrium +xref: XAO:0003191 is_a: UBERON:0002081 ! cardiac atrium is_a: UBERON:0035553 ! left cardiac chamber intersection_of: UBERON:0002081 ! cardiac atrium intersection_of: BSPO:0000120 UBERON:0000948 ! heart relationship: RO:0002170 UBERON:0004537 ! blood vasculature -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002080 name: heart right ventricle +def: "A cardiac ventricle that is in the right side of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0001630 +xref: CALOHA:TS-0443 +xref: EHDAA2:0000196 +xref: EMAPA:17340 +xref: FMA:7098 +xref: galen:RightVentricle +xref: MA:0000093 +xref: NCIT:C12870 +xref: SCTID:244384009 +xref: VHOG:0000717 +xref: Wikipedia:Right_ventricle is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035554 ! right cardiac chamber intersection_of: UBERON:0002082 ! cardiac ventricle @@ -34898,11 +49925,31 @@ intersection_of: BSPO:0000121 UBERON:0000948 ! heart relationship: RO:0002170 UBERON:0004537 ! blood vasculature relationship: RO:0002202 UBERON:0009889 ! secondary heart field relationship: RO:0002254 UBERON:0004706 ! bulbus cordis -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002081 name: cardiac atrium +def: "Cardiac chamber in which blood enters the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Heart_atrium] +xref: AAO:0010246 +xref: BTO:0000903 +xref: CALOHA:TS-0437 +xref: EFO:0000277 +xref: EHDAA2:0000154 +xref: EHDAA:1265 +xref: EMAPA:16688 +xref: EV:0100019 +xref: FMA:7099 +xref: GAID:555 +xref: galen:Atrium +xref: MA:0000073 +xref: MAT:0000496 +xref: MESH:D006325 +xref: NCIT:C12728 +xref: SCTID:261405004 +xref: TAO:0000471 +xref: VHOG:0000175 +xref: Wikipedia:Heart_atrium +xref: ZFA:0000471 is_a: UBERON:0004151 ! cardiac chamber relationship: RO:0002433 UBERON:0000948 ! heart relationship: RO:0002495 UBERON:0010227 ! future cardiac atrium @@ -34910,6 +49957,28 @@ relationship: RO:0002495 UBERON:0010227 ! future cardiac atrium [Term] id: UBERON:0002082 name: cardiac ventricle +def: "Cardiac chamber through which blood leaves the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Ventricle_(heart)] +xref: AAO:0010249 +xref: BTO:0000862 +xref: CALOHA:TS-0444 +xref: EFO:0000317 +xref: EHDAA2:0004164 +xref: EHDAA:1912 +xref: EMAPA:17331 +xref: EV:0100020 +xref: FMA:7100 +xref: GAID:568 +xref: galen:Ventricle +xref: MA:0000091 +xref: MAT:0000497 +xref: MESH:D006352 +xref: NCIT:C12730 +xref: SCTID:277699000 +xref: TAO:0000009 +xref: VHOG:0000435 +xref: Wikipedia:Ventricle_(heart) +xref: XAO:0003193 +xref: ZFA:0000009 is_a: UBERON:0004151 ! cardiac chamber relationship: RO:0002433 UBERON:0000948 ! heart relationship: RO:0002495 UBERON:0006283 ! future cardiac ventricle @@ -34917,6 +49986,18 @@ relationship: RO:0002495 UBERON:0006283 ! future cardiac ventricle [Term] id: UBERON:0002084 name: heart left ventricle +def: "A cardiac ventricle that is in the left side of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0001629 +xref: CALOHA:TS-0439 +xref: EHDAA2:0002178 +xref: EMAPA:17337 +xref: FMA:7101 +xref: galen:LeftVentricle +xref: MA:0000092 +xref: NCIT:C12871 +xref: SCTID:244385005 +xref: VHOG:0000718 +xref: Wikipedia:Left_ventricle is_a: UBERON:0002082 ! cardiac ventricle is_a: UBERON:0035553 ! left cardiac chamber intersection_of: UBERON:0002082 ! cardiac ventricle @@ -34924,11 +50005,21 @@ intersection_of: BSPO:0000120 UBERON:0000948 ! heart relationship: RO:0002150 UBERON:0000947 ! aorta relationship: RO:0002170 UBERON:0004537 ! blood vasculature relationship: RO:0002202 UBERON:0004140 ! primary heart field -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002085 name: interatrial septum +def: "A cardiac septum that divides the left and right atria of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0000838 +xref: EHDAA:1896 +xref: EMAPA:17011 +xref: FMA:7108 +xref: galen:InteratrialSeptum +xref: MA:0000084 +xref: NCIT:C32818 +xref: SCTID:362016003 +xref: VHOG:0000385 +xref: Wikipedia:Interatrial_septum is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: RO:0002220 UBERON:0002078 ! adjacent to right cardiac atrium @@ -34939,6 +50030,21 @@ relationship: RO:0002220 UBERON:0002079 ! adjacent to left cardiac atrium [Term] id: UBERON:0002090 name: postcranial axial skeleton +def: "The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]." [https://sourceforge.net/tracker/?func=detail&aid=2983975&group_id=76834&atid=974957, https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=2983977&group_id=76834, ZFA:0000317] +comment: previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed. +xref: AAO:0000034 +xref: EFO:0000942 +xref: EHDAA2:0000161 +xref: EHDAA:5049 +xref: FMA:71221 +xref: MA:0002986 +xref: MAT:0000148 +xref: MIAA:0000148 +xref: TAO:0000317 +xref: VHOG:0000317 +xref: VSAO:0000093 +xref: XAO:0003073 +xref: ZFA:0000317 is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0005944 ! part of axial skeleton plus cranial skeleton relationship: BFO:0000050 UBERON:0011138 ! part of postcranial axial skeletal system @@ -34947,37 +50053,98 @@ relationship: RO:0002202 UBERON:0003089 ! sclerotome [Term] id: UBERON:0002091 name: appendicular skeleton +def: "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003, Wikipedia:Appendicular_skeleton] +xref: AAO:0000747 +xref: EFO:0000951 +xref: EMAPA:32729 +xref: FMA:71222 +xref: MA:0000290 +xref: MAT:0000278 +xref: MIAA:0000278 +xref: NCIT:C49477 +xref: SCTID:322050006 +xref: VSAO:0000076 +xref: Wikipedia:Appendicular_skeleton +xref: XAO:0003166 is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0011249 ! part of appendicular skeletal system relationship: RO:0002131 UBERON:0000026 ! overlaps appendage relationship: RO:0002160 NCBITaxon:7776 ! Gnathostomata relationship: RO:0002433 UBERON:0001434 ! skeletal system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002094 name: interventricular septum +def: "Cardiac septum which separates the right ventricle from the left ventricle.[FMA]." [FMA:7133] +xref: BTO:0002483 +xref: EFO:0001956 +xref: EHDAA:2603 +xref: EMAPA:17333 +xref: FMA:7133 +xref: galen:InterventricularSeptum +xref: MA:0000085 +xref: NCIT:C32874 +xref: SCTID:362019005 +xref: VHOG:0000386 +xref: Wikipedia:Interventricular_septum is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: RO:0002220 UBERON:0002080 ! adjacent to heart right ventricle intersection_of: RO:0002220 UBERON:0002084 ! adjacent to heart left ventricle relationship: RO:0002220 UBERON:0002080 ! adjacent to heart right ventricle relationship: RO:0002220 UBERON:0002084 ! adjacent to heart left ventricle -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002095 +name: mesentery +def: "Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon." [FMA:7144, https://github.com/obophenotype/uberon/issues/85, Wikipedia:Mesentery, Wikipedia:Mesentery#Mesentery_.28general.29] +xref: AAO:0011061 +xref: BTO:0001380 +xref: EV:0100083 +xref: FMA:7144 +xref: GAID:21 +xref: galen:Mesentery +xref: MESH:D008643 +xref: NCIT:C33103 +xref: SCTID:362707009 +xref: Wikipedia:Mesentery#Mesentery_.28general.29 +is_a: UBERON:0000042 ! serous membrane +relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0002097 name: skin of body +def: "The organ covering the body that consists of the dermis and epidermis." [UBERON:cjm] +xref: BTO:0001253 +xref: CALOHA:TS-0934 +xref: EFO:0000962 +xref: EHDAA2:0001844 +xref: EMAPA:17525 +xref: FMA:7163 +xref: galen:Skin +xref: MESH:D012867 +xref: MFMO:0000099 +xref: NCIT:C12470 +xref: SCTID:181469002 +xref: Wikipedia:Skin +xref: XAO:0000023 is_a: UBERON:0000062 ! organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0002199 ! part of integument relationship: RO:0002202 UBERON:0011272 ! embryonic skin basal layer relationship: RO:0002473 UBERON:0000014 ! zone of skin -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002099 name: cardiac septum +def: "The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles." [MESH:A07.541.459] +xref: EMAPA:35400 +xref: FMA:7180 +xref: GAID:562 +xref: MA:0000083 +xref: MESH:D006346 +xref: NCIT:C49485 +xref: SCTID:362014000 is_a: UBERON:0003037 ! septum is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003037 ! septum @@ -34989,6 +50156,25 @@ relationship: RO:0002433 UBERON:0000948 ! heart [Term] id: UBERON:0002100 name: trunk +def: "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present." [TAO:0001115, UBERONREF:0000006, Wikipedia:Torso] +xref: AAO:0010339 +xref: BILA:0000116 +xref: BTO:0001493 +xref: CALOHA:TS-1071 +xref: EFO:0000966 +xref: EMAPA:31857 +xref: FMA:7181 +xref: galen:Trunk +xref: MA:0000004 +xref: MAT:0000296 +xref: MIAA:0000296 +xref: NCIT:C33816 +xref: SCTID:262225004 +xref: TAO:0001115 +xref: Wikipedia:Torso +xref: XAO:0000054 +xref: XAO:0003025 +xref: ZFA:0001115 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: BFO:0000050 UBERON:0013702 ! part of body proper relationship: BFO:0000051 UBERON:0000915 {gci_filler="NCBITaxon:7742", gci_relation="BFO:0000050"} ! has part thoracic segment of trunk @@ -34997,18 +50183,181 @@ relationship: BFO:0000051 UBERON:0000916 {gci_filler="NCBITaxon:7742", gci_relat [Term] id: UBERON:0002104 name: visual system +def: "The sensory system subserving the sense of vision." [NIFSTD:FMAID_7191] +xref: AAO:0000632 +xref: BILA:0000140 +xref: EMAPA:36003 +xref: FMA:7191 +xref: http://uri.neuinfo.org/nif/nifstd/FMAID_7191 +xref: MA:0002444 +xref: NCIT:C12888 +xref: SCTID:281831001 +xref: TAO:0001127 +xref: Wikipedia:Visual_system +xref: XAO:0003198 +xref: ZFA:0001127 is_a: UBERON:0001032 ! sensory system relationship: RO:0002216 GO:0007601 ! capable of part of visual perception [Term] id: UBERON:0002105 name: vestibulo-auditory system +def: "Sensory system responsible for the perception of spatial orientation and auditory stimuli." [ZFA:0001138] +xref: AAO:0000631 +xref: FMA:78500 +xref: TAO:0001138 +xref: XAO:0003195 +xref: ZFA:0001138 is_a: UBERON:0001032 ! sensory system relationship: RO:0002216 GO:0007605 ! capable of part of sensory perception of sound +[Term] +id: UBERON:0002106 +name: spleen +def: "The organ that functions to filter blood and to store red corpuscles and platelets." [ISBN:0-683-40008-8, MP:0000689] +xref: AAO:0010395 +xref: BTO:0001281 +xref: CALOHA:TS-0956 +xref: EFO:0000869 +xref: EMAPA:18767 +xref: EV:0100055 +xref: FMA:7196 +xref: GAID:1289 +xref: galen:Spleen +xref: MA:0000141 +xref: MAT:0000085 +xref: MESH:D013154 +xref: MIAA:0000085 +xref: NCIT:C12432 +xref: SCTID:181279003 +xref: TAO:0000436 +xref: VHOG:0000120 +xref: Wikipedia:Spleen +xref: XAO:0000328 +xref: ZFA:0000436 +is_a: UBERON:0004177 ! hemopoietic organ +is_a: UBERON:0005057 ! immune organ +is_a: UBERON:0017672 ! abdominal viscera +relationship: RO:0002160 NCBITaxon:7776 ! Gnathostomata +relationship: RO:0002202 UBERON:0006293 ! spleen primordium + +[Term] +id: UBERON:0002107 +name: liver +def: "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." [BTO:0000759, Wikipedia:Liver] +xref: AAO:0010111 +xref: BTO:0000759 +xref: CALOHA:TS-0564 +xref: EFO:0000887 +xref: EHDAA2:0000997 +xref: EHDAA:2197 +xref: EMAPA:16846 +xref: EV:0100089 +xref: FMA:7197 +xref: GAID:288 +xref: galen:Liver +xref: MA:0000358 +xref: MAT:0000097 +xref: MESH:D008099 +xref: MIAA:0000097 +xref: NCIT:C12392 +xref: SCTID:181268008 +xref: TAO:0000123 +xref: VHOG:0000257 +xref: Wikipedia:Liver +xref: XAO:0000133 +xref: ZFA:0000123 +is_a: UBERON:0002365 ! exocrine gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005172 ! abdomen element +is_a: UBERON:0006925 ! digestive system gland +relationship: BFO:0000050 UBERON:0002423 ! part of hepatobiliary system +relationship: BFO:0000051 UBERON:0004647 ! has part liver lobule +relationship: RO:0002131 UBERON:0002405 ! overlaps immune system +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002202 UBERON:0004161 ! septum transversum +relationship: RO:0002202 UBERON:0008836 ! liver bud +relationship: RO:0002433 UBERON:0002423 ! hepatobiliary system +relationship: RO:0003000 UBERON:0001970 ! produces bile +relationship: site_of GO:0002384 ! hepatic immune response +relationship: site_of GO:0005978 ! glycogen biosynthetic process +relationship: site_of GO:0005980 ! glycogen catabolic process + +[Term] +id: UBERON:0002108 +name: small intestine +def: "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]." [ISBN:0073040584, Wikipedia:Small_intestine] +xref: AAO:0010397 +xref: BTO:0000651 +xref: CALOHA:TS-0942 +xref: EFO:0000841 +xref: EMAPA:32834 +xref: EV:0100072 +xref: FMA:7200 +xref: GAID:313 +xref: galen:SmallIntestine +xref: MA:0000337 +xref: MAT:0000047 +xref: MESH:D007421 +xref: MIAA:0000047 +xref: NCIT:C12386 +xref: SCTID:181250005 +xref: TAO:0001323 +xref: VHOG:0000055 +xref: Wikipedia:Small_intestine +xref: XAO:0000130 +xref: ZFA:0001323 +is_a: UBERON:0004921 ! subdivision of digestive tract +is_a: UBERON:0013765 ! digestive system element +relationship: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002433 UBERON:0000160 ! intestine + +[Term] +id: UBERON:0002110 +name: gallbladder +def: "An organ that aids digestion and stores bile produced by the liver[WP]." [Wikipedia:Gallbladder] +comment: Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988) +xref: AAO:0010114 +xref: BTO:0000493 +xref: CALOHA:TS-0394 +xref: EFO:0000853 +xref: EHDAA2:0000699 +xref: EHDAA:8062 +xref: EMAPA:17202 +xref: EV:0100090 +xref: FMA:7202 +xref: galen:Gallbladder +xref: MA:0000356 +xref: MAT:0000072 +xref: MESH:D005704 +xref: MIAA:0000072 +xref: NCIT:C12377 +xref: SCTID:181269000 +xref: TAO:0000208 +xref: VHOG:0000221 +xref: Wikipedia:Gallbladder +xref: XAO:0000135 +xref: ZFA:0000208 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0013765 ! digestive system element +is_a: UBERON:0017672 ! abdominal viscera +is_a: UBERON:0018707 ! bladder organ +relationship: BFO:0000050 UBERON:0002294 ! part of biliary system +relationship: RO:0002202 UBERON:0004912 ! biliary bud +relationship: RO:0002202 UBERON:0006242 ! gallbladder primordium +relationship: RO:0002433 UBERON:0001173 ! biliary tree + [Term] id: UBERON:0002111 name: artery smooth muscle tissue +def: "A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000087 +xref: CALOHA:TS-1198 +xref: EMAPA:36285 +xref: FMA:72024 +xref: MA:0000708 +xref: NCIT:C49195 is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -35018,15 +50367,52 @@ relationship: BFO:0000050 UBERON:0001637 ! part of artery [Term] id: UBERON:0002112 name: smooth muscle of esophagus +def: "A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35323 +xref: FMA:72025 +xref: MA:0001573 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0003832 ! part of esophagus muscle relationship: RO:0002433 UBERON:0001043 ! esophagus +[Term] +id: UBERON:0002114 +name: duodenum +def: "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one)." [ISBN:0815318960, Wikipedia:Duodenum] +xref: AAO:0010402 +xref: BTO:0000365 +xref: CALOHA:TS-0214 +xref: EFO:0000851 +xref: EMAPA:18852 +xref: EV:0100073 +xref: FMA:7206 +xref: GAID:284 +xref: galen:Duodenum +xref: MA:0000338 +xref: MAT:0000044 +xref: MESH:D004386 +xref: MIAA:0000044 +xref: NCIT:C12263 +xref: SCTID:181247007 +xref: VHOG:0000052 +xref: Wikipedia:Duodenum +xref: XAO:0000236 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BSPO:0001106 UBERON:0002108 ! small intestine +relationship: RO:0002150 UBERON:0001166 ! pylorus +relationship: RO:0002433 UBERON:0002108 ! small intestine + [Term] id: UBERON:0002118 name: right ovary +def: "An ovary that is part of a right side of organism [Automatically generated definition]." [OBOL:automatic] +xref: FMA:7213 +xref: MA:0001705 +xref: NCIT:C33487 +xref: SCTID:280123002 is_a: UBERON:0000992 ! ovary is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000992 ! ovary @@ -35036,6 +50422,11 @@ relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0002119 name: left ovary +def: "An ovary that is part of a left side of organism [Automatically generated definition]." [OBOL:automatic] +xref: FMA:7214 +xref: MA:0001704 +xref: NCIT:C32969 +xref: SCTID:280124008 is_a: UBERON:0000992 ! ovary is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000992 ! ovary @@ -35045,6 +50436,18 @@ relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0002128 name: superior olivary complex +def: "A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system." [ISBN:0-19-502694-2, Wikipedia:Superior_olivary_complex] +xref: BAMS:SOC +xref: BIRNLEX:1307 +xref: DHBA:12462 +xref: EMAPA:35840 +xref: EV:0100263 +xref: FMA:72247 +xref: HBA:9177 +xref: MA:0001026 +xref: MBA:398 +xref: VHOG:0001381 +xref: Wikipedia:Superior_olivary_complex is_a: UBERON:0007245 ! nuclear complex of neuraxis is_a: UBERON:0019263 ! gray matter of hindbrain relationship: BFO:0000050 UBERON:0003023 ! part of pontine tegmentum @@ -35053,6 +50456,27 @@ relationship: BFO:0000050 UBERON:0016490 ! part of auditory system [Term] id: UBERON:0002148 name: locus ceruleus +def: "The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]." [GAID:577, GO:0021703, Wikipedia:Locus_ceruleus] +xref: BAMS:CAE +xref: BAMS:LC +xref: BIRNLEX:905 +xref: BM:Pons-LC +xref: BTO:0001408 +xref: DHBA:12819 +xref: DMBA:16972 +xref: EFO:0001963 +xref: EMAPA:35502 +xref: FMA:72478 +xref: GAID:577 +xref: HBA:9148 +xref: MA:0001017 +xref: MBA:147 +xref: MESH:D008125 +xref: NCIT:C97333 +xref: SCTID:369016004 +xref: TAO:0000539 +xref: Wikipedia:Locus_ceruleus +xref: ZFA:0000539 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus is_a: UBERON:8440015 ! noradrenergic cell groups @@ -35062,6 +50486,18 @@ relationship: RO:0002215 GO:0048243 ! capable of norepinephrine secretion [Term] id: UBERON:0002149 name: superior salivatory nucleus +def: "Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703)." [BIRNLEX:1131] +xref: BAMS:SSN +xref: BAMS:SuS +xref: BIRNLEX:1131 +xref: DHBA:12435 +xref: EHDAA2:0004646 +xref: FMA:72482 +xref: HBA:9194 +xref: MA:0001027 +xref: MBA:462 +xref: SCTID:369028007 +xref: Wikipedia:Superior_salivatory_nucleus is_a: UBERON:0000126 ! cranial nerve nucleus is_a: UBERON:0004133 ! salivatory nucleus is_a: UBERON:0007635 ! nucleus of medulla oblongata @@ -35071,6 +50507,29 @@ relationship: RO:0002495 UBERON:0010125 ! future superior salivatory nucleus [Term] id: UBERON:0002165 name: endocardium +def: "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]." [GO:0003157] +comment: fixed in GO to reflect FMA. See email to David/Varsha June 18 2010 +xref: AAO:0010408 +xref: BTO:0000387 +xref: CALOHA:TS-2075 +xref: EFO:0000821 +xref: EHDAA2:0004153 +xref: EMAPA:17868 +xref: EMAPA:32686 +xref: EV:0100021 +xref: FMA:7280 +xref: GAID:550 +xref: galen:Endocardium +xref: MA:0000076 +xref: MAT:0000455 +xref: MESH:D004699 +xref: NCIT:C13004 +xref: SCTID:362013006 +xref: TAO:0001320 +xref: VHOG:0000084 +xref: Wikipedia:Endocardium +xref: XAO:0000066 +xref: ZFA:0001320 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0005983 ! heart layer relationship: BFO:0000051 UBERON:0005316 ! has part endocardial endothelium @@ -35079,6 +50538,14 @@ relationship: RO:0002495 UBERON:0007280 ! presumptive endocardium [Term] id: UBERON:0002166 name: endocardium of atrium +def: "Endocardium that is part of the atrium." [ZFIN:curator] +xref: EMAPA:32745 +xref: FMA:7284 +xref: MA:0000077 +xref: SCTID:192001005 +xref: TAO:0002169 +xref: VHOG:0000606 +xref: ZFA:0001614 is_a: UBERON:0002165 ! endocardium intersection_of: UBERON:0002165 ! endocardium intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium @@ -35088,6 +50555,16 @@ relationship: RO:0002433 UBERON:0002081 ! cardiac atrium [Term] id: UBERON:0002167 name: right lung +def: "Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]." [FMA:FMA, Wikipedia:Right_lung] +xref: EHDAA2:0001730 +xref: EHDAA:4969 +xref: EMAPA:17661 +xref: FMA:7309 +xref: MA:0000426 +xref: NCIT:C33483 +xref: SCTID:361967000 +xref: VHOG:0000301 +xref: Wikipedia:Right_lung is_a: UBERON:0002048 ! lung intersection_of: UBERON:0002048 ! lung intersection_of: BSPO:0000121 UBERON:0000170 ! pair of lungs @@ -35096,6 +50573,16 @@ relationship: BSPO:0000121 UBERON:0000170 ! pair of lungs [Term] id: UBERON:0002168 name: left lung +def: "Lung which consists of the left upper lobe and left lower lobe.[FMA]." [FMA:FMA, Wikipedia:Left_lung] +xref: EHDAA2:0000943 +xref: EHDAA:4947 +xref: EMAPA:17653 +xref: FMA:7310 +xref: MA:0000425 +xref: NCIT:C32967 +xref: SCTID:361982005 +xref: VHOG:0000618 +xref: Wikipedia:Left_lung is_a: UBERON:0002048 ! lung intersection_of: UBERON:0002048 ! lung intersection_of: BSPO:0000120 UBERON:0000170 ! pair of lungs @@ -35104,6 +50591,14 @@ relationship: BSPO:0000120 UBERON:0000170 ! pair of lungs [Term] id: UBERON:0002169 name: alveolar sac +def: "The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters." [MP:0010902, Wikipedia:Alveolar_sac] +xref: BTO:0000061 +xref: EMAPA:35119 +xref: FMA:7317 +xref: MA:0000418 +xref: NCIT:C32057 +xref: SCTID:361964007 +xref: Wikipedia:Alveolar_sac is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0000117 ! respiratory tube is_a: UBERON:0007499 ! epithelial sac @@ -35117,21 +50612,57 @@ relationship: RO:0002433 UBERON:0008874 ! pulmonary acinus [Term] id: UBERON:0002173 name: pulmonary alveolar duct +def: "The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli." [ISBN:0-683-40008-8, MGI:cwg, MP:0002271] +xref: EMAPA:32694 +xref: FMA:7341 +xref: MA:0000417 +xref: NCIT:C32056 +xref: Wikipedia:Alveolar_duct is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0006524 ! part of alveolar system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002185 name: bronchus +def: "The upper conducting airways of the lung; these airways arise from the terminus of the trachea." [ISBN:0-397-51047-0, MESH:A04.411.125, MGI:cwg, MP:0002264] +xref: BTO:0001340 +xref: CALOHA:TS-1229 +xref: EFO:0000932 +xref: EMAPA:32689 +xref: EV:0100041 +xref: FMA:7409 +xref: GAID:346 +xref: MA:0000436 +xref: MAT:0000133 +xref: MESH:D001980 +xref: MIAA:0000133 +xref: NCIT:C12683 +xref: SCTID:181215002 +xref: VHOG:0000262 +xref: Wikipedia:Bronchus +xref: XAO:0000121 is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: RO:0001025 UBERON:0002224 ! thoracic cavity -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002186 name: bronchiole +def: "The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching." [ISBN:0-397-51047-0, MGI:cwg, MP:0002267] +comment: In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole. {xref="https://github.com/obophenotype/uberon/issues/2795"} +xref: BTO:0002375 +xref: CALOHA:TS-2003 +xref: EHDAA:8171 +xref: EHDAA:8183 +xref: EHDAA:8199 +xref: EHDAA:8221 +xref: EMAPA:32697 +xref: FMA:7410 +xref: MA:0000422 +xref: NCIT:C12684 +xref: SCTID:278982001 +xref: VHOG:0000675 +xref: Wikipedia:Bronchiole is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002380 UBERON:0007196 ! tracheobronchial tree @@ -35139,53 +50670,91 @@ relationship: RO:0002380 UBERON:0007196 ! tracheobronchial tree [Term] id: UBERON:0002187 name: terminal bronchiole +def: "A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls." [ISBN:0-397-51047-0, MGI:cwg, MP:0002268, PMID:16543587] +xref: BTO:0003223 +xref: EMAPA:36282 +xref: FMA:7411 +xref: MA:0000424 +xref: NCIT:C33754 +xref: SCTID:278981008 +xref: Wikipedia:Terminal_bronchiole is_a: UBERON:0002186 ! bronchiole relationship: BFO:0000050 UBERON:0010369 ! part of secondary pulmonary lobule relationship: distally_connected_to UBERON:0002188 ! respiratory bronchiole relationship: distally_connected_to UBERON:0008874 ! pulmonary acinus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002188 name: respiratory bronchiole +def: "A bronchiole that is the first segment of the respiratory zone." [ISBN:0123813611, Wikipedia:Respiratory_bronchiole] +xref: BTO:0003222 +xref: EMAPA:35729 +xref: FMA:7412 +xref: MA:0000423 +xref: NCIT:C33465 +xref: SCTID:128517006 +xref: Wikipedia:Respiratory_bronchiole is_a: UBERON:0002186 ! bronchiole relationship: BFO:0000050 UBERON:0008874 ! part of pulmonary acinus relationship: distally_connected_to UBERON:0002173 ! pulmonary alveolar duct relationship: proximally_connected_to UBERON:0002187 ! terminal bronchiole relationship: RO:0002433 UBERON:0008874 ! pulmonary acinus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002190 name: subcutaneous adipose tissue +def: "A portion of adipose tissue that is part of the hypodermis, beneath the dermis." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0004042 +xref: EMAPA:35829 +xref: FMA:74315 +xref: MA:0000473 is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: RO:0002433 UBERON:0002072 ! hypodermis -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002193 name: hemolymphoid system +def: "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs." [http://orcid.org/0000-0002-6601-2165] +xref: CALOHA:TS-2018 +xref: EHDAA2:0004615 +xref: EMAPA:18765 +xref: FMA:74562 +xref: MA:0000013 is_a: UBERON:0000467 ! anatomical system relationship: RO:0002160 NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0002199 name: integument +def: "The dermis, epidermis and hypodermis." [Wikipedia:Integument] +xref: AAO:0000239 +xref: BTO:0000634 +xref: FMA:74657 +xref: galen:Integument +xref: TAO:0000368 +xref: VSAO:0000029 +xref: Wikipedia:Integument +xref: ZFA:0000368 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002416 ! part of integumental system relationship: BFO:0000051 UBERON:0002072 ! has part hypodermis relationship: BFO:0000051 UBERON:0002097 ! has part skin of body relationship: RO:0002007 UBERON:0000468 ! bounding layer of multicellular organism relationship: RO:0002160 NCBITaxon:7711 ! Chordata -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002200 name: vasculature of head +def: "Vasculature that is part of a head [Automatically generated definition]." [OBOL:automatic] +xref: EFO:0003656 +xref: FMA:74710 +xref: TAO:0001267 +xref: XAO:0004152 +xref: ZFA:0001267 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -35194,6 +50763,10 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0002201 name: vasculature of trunk +def: "A vasculature that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +xref: FMA:74712 +xref: TAO:0005024 +xref: ZFA:0005024 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -35202,32 +50775,59 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0002202 name: submucosa of trachea +def: "A submucosa that is part of a trachea." [OBOL:automatic] +xref: BTO:0002115 +xref: EMAPA:35879 +xref: FMA:7472 +xref: MA:0001860 +xref: NCIT:C49307 +xref: SCTID:4419000 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002203 name: vasculature of eye +def: "Vasculature that is part of the eye region." [https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726, OBOL:automatic] +xref: FMA:74743 +xref: SCTID:123846009 +xref: TAO:0007057 +xref: ZFA:0007057 is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: RO:0002202 UBERON:0003314 ! eye mesenchyme -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002204 name: musculoskeletal system +def: "Anatomical system that consists of the muscular and skeletal systems." [https://github.com/obophenotype/uberon/issues/77, VSAO:0000031, VSAO:curator] +xref: AAO:0010546 +xref: CALOHA:TS-1311 +xref: EMAPA:32714 +xref: EV:0100139 +xref: FMA:7482 +xref: GAID:98 +xref: MA:0002418 +xref: MESH:D009141 +xref: NCIT:C12754 +xref: SCTID:278858007 +xref: VHOG:0001275 +xref: VSAO:0000031 +xref: Wikipedia:Musculoskeletal_system +xref: XAO:0000168 is_a: UBERON:0000467 ! anatomical system +disjoint_from: UBERON:0002294 ! biliary system disjoint_from: UBERON:0002330 ! exocrine system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 UBERON:0000383 ! has part musculature of body @@ -35239,6 +50839,14 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0002213 name: cartilaginous joint +def: "Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]." [FMA:FMA, Wikipedia:Cartilaginous_joint] +xref: EMAPA:36581 +xref: FMA:7496 +xref: MA:0000320 +xref: SCTID:58442004 +xref: TAO:0005155 +xref: Wikipedia:Cartilaginous_joint +xref: ZFA:0005155 is_a: UBERON:0011134 ! nonsynovial joint intersection_of: UBERON:0011134 ! nonsynovial joint intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue @@ -35247,6 +50855,18 @@ relationship: RO:0002473 UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0002217 name: synovial joint +def: "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]." [FMA:7501, Wikipedia:Synovial_joint] +xref: AEO:0000183 +xref: CALOHA:TS-2138 +xref: EHDAA2:0003183 +xref: FMA:7501 +xref: galen:SynovialJoint +xref: MA:0000322 +xref: NCIT:C32461 +xref: SCTID:113234001 +xref: TAO:0005153 +xref: Wikipedia:Synovial_joint +xref: ZFA:0005153 is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: RO:0002219 UBERON:0001484 ! articular capsule @@ -35257,6 +50877,15 @@ relationship: RO:0002219 UBERON:0001484 ! articular capsule [Term] id: UBERON:0002224 name: thoracic cavity +def: "The part of the coelemic cavity lumen that is enclosed by the walls of the thorax." [UBERON:cjm, Wikipedia:Thoracic_cavity] +xref: EMAPA:36497 +xref: FMA:7565 +xref: GAID:93 +xref: MA:0000032 +xref: MESH:D035423 +xref: NCIT:C12905 +xref: SCTID:243949006 +xref: Wikipedia:Thoracic_cavity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen @@ -35267,6 +50896,34 @@ relationship: RO:0002572 UBERON:0000915 ! thoracic segment of trunk [Term] id: UBERON:0002240 name: spinal cord +def: "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO)." [BIRNLEX:1709] +xref: AAO:0010151 +xref: BAMS:SP +xref: BAMS:Spinal +xref: BIRNLEX:1709 +xref: BM:SpC +xref: BTO:0001279 +xref: CALOHA:TS-0953 +xref: DHBA:12890 +xref: DMBA:17651 +xref: EFO:0000110 +xref: EHDAA2:0001255 +xref: EHDAA:2863 +xref: EMAPA:17577 +xref: EV:0100316 +xref: FMA:7647 +xref: GAID:695 +xref: MA:0000216 +xref: MAT:0000183 +xref: MESH:D013116 +xref: MIAA:0000183 +xref: NCIT:C12464 +xref: SCTID:180959008 +xref: TAO:0000075 +xref: VHOG:0000601 +xref: Wikipedia:Spinal_cord +xref: XAO:0000020 +xref: ZFA:0000075 is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005174 ! dorsal region element @@ -35276,17 +50933,39 @@ relationship: BFO:0000051 CL:0005000 ! has part spinal cord interneuron relationship: RO:0002202 UBERON:0003076 ! posterior neural tube relationship: RO:0002254 UBERON:0003853 ! spinal cord neural crest relationship: RO:0002495 UBERON:0006241 ! future spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002241 name: chondrocranium +def: "Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]." [http://medical-dictionary.thefreedictionary.com/chondrocranium, Wikipedia:Chondrocranium] +xref: AAO:0010169 +xref: EHDAA2:0000243 +xref: EMAPA:17681 +xref: TAO:0001424 +xref: VHOG:0000288 +xref: Wikipedia:Chondrocranium +xref: ZFA:0001424 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system relationship: RO:0002131 UBERON:0001703 ! overlaps neurocranium [Term] id: UBERON:0002257 name: ventral horn of spinal cord +def: "The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]." [GO:0021517, https://sourceforge.net/tracker/?group_id=36855&atid=440764, MP:0005112, Wikipedia:Anterior_horn_of_spinal_cord] +xref: BAMS:VH +xref: BIRNLEX:2668 +xref: BTO:0005151 +xref: EMAPA:18575 +xref: EMAPA:35794 +xref: FMA:256541 +xref: MA:0001134 +xref: NCIT:C33859 +xref: neuronames:1751 +xref: SCTID:279443000 +xref: TAO:0000702 +xref: VHOG:0001288 +xref: Wikipedia:Anterior_horn_of_spinal_cord +xref: ZFA:0000702 is_a: UBERON:0015212 ! lateral structure is_a: UBERON:0016550 ! spinal cord column relationship: BFO:0000050 UBERON:0002315 ! part of gray matter of spinal cord @@ -35297,12 +50976,89 @@ relationship: RO:0002433 UBERON:0002315 ! gray matter of spinal cord [Term] id: UBERON:0002275 name: reticular formation +def: "A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 )." [NeuroNames:1223] +xref: BAMS:RET +xref: EMAPA:35188 +xref: FMA:77719 +xref: MA:0003185 +xref: MESH:D012154 +xref: neuronames:1223 +xref: NLX:143558 +xref: SCTID:361552007 +xref: Wikipedia:Reticular_formation is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002298 ! part of brainstem +[Term] +id: UBERON:0002294 +name: biliary system +def: "Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree)." [Wikipedia:Biliary_system] +xref: FMA:79646 +xref: GAID:279 +xref: MA:0001273 +xref: MESH:D001659 +xref: NCIT:C12678 +xref: SCTID:361354009 +xref: Wikipedia:Biliary_system +is_a: UBERON:0011216 ! organ system subdivision +intersection_of: UBERON:0011216 ! organ system subdivision +intersection_of: BFO:0000051 UBERON:0001173 ! has part biliary tree +intersection_of: RO:0002215 GO:0006699 ! capable of bile acid biosynthetic process +intersection_of: RO:0002215 GO:0015721 ! capable of bile acid and bile salt transport +disjoint_from: UBERON:0002330 ! exocrine system +disjoint_from: UBERON:0002390 ! hematopoietic system +disjoint_from: UBERON:0002405 ! immune system +disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system +disjoint_from: UBERON:0004456 ! entire sense organ system +disjoint_from: UBERON:8450002 ! excretory system +relationship: BFO:0000050 UBERON:0002423 ! part of hepatobiliary system +relationship: BFO:0000051 UBERON:0001173 ! has part biliary tree +relationship: RO:0002215 GO:0006699 ! capable of bile acid biosynthetic process +relationship: RO:0002215 GO:0015721 ! capable of bile acid and bile salt transport + +[Term] +id: UBERON:0002296 +name: dorsal mesentery +def: "The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]." [Wikipedia:Dorsal_mesentery, Wikipedia:Mesentery#Development, ZFIN:curator] +xref: EHDAA2:0004560 +xref: EHDAA:3019 +xref: EHDAA:3033 +xref: EHDAA:3921 +xref: EHDAA:3934 +xref: EHDAA:3957 +xref: EHDAA:3971 +xref: FMA:79795 +xref: SCTID:308823000 +xref: TAO:0005130 +xref: Wikipedia:Mesentery#Development +xref: ZFA:0005130 +is_a: UBERON:0006598 ! presumptive structure +relationship: BFO:0000050 UBERON:0009664 ! part of gut mesentery +relationship: RO:0002387 UBERON:0002095 ! mesentery + [Term] id: UBERON:0002298 name: brainstem +def: "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]." [ISBN:0471888893, MP:0005277, Wikipedia:Brainstem, ZFA:0001707] +comment: 'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions). +xref: BAMS:BS +xref: BIRNLEX:1565 +xref: BTO:0000146 +xref: CALOHA:TS-0093 +xref: EFO:0001962 +xref: EMAPA:32678 +xref: EV:0100241 +xref: FMA:79876 +xref: MA:0000169 +xref: MBA:343 +xref: MESH:D001933 +xref: NCIT:C12441 +xref: SCTID:180925009 +xref: TAO:0002156 +xref: VHOG:0001457 +xref: Wikipedia:Brainstem +xref: ZFA:0001707 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000051 UBERON:0001896 ! has part medulla oblongata relationship: BFO:0000051 UBERON:0001943 ! has part midbrain tegmentum @@ -35312,6 +51068,18 @@ relationship: RO:0002433 UBERON:0000955 ! brain [Term] id: UBERON:0002299 name: alveolus of lung +def: "Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]." [Wikipedia:Pulmonary_alveolus] +xref: BTO:0000060 +xref: CALOHA:TS-0031 +xref: EFO:0001985 +xref: EMAPA:32682 +xref: FMA:7318 +xref: GAID:349 +xref: MA:0000420 +xref: MESH:D011650 +xref: SCTID:361364000 +xref: VHOG:0001445 +xref: Wikipedia:Pulmonary_alveolus is_a: UBERON:0003215 ! alveolus is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0003215 ! alveolus @@ -35321,11 +51089,19 @@ relationship: BFO:0000050 UBERON:0008874 ! part of pulmonary acinus relationship: BFO:0000067 GO:0007585 ! respiratory gaseous exchange by respiratory system relationship: RO:0002160 NCBITaxon:40674 ! Mammalia relationship: RO:0002433 UBERON:0008874 ! pulmonary acinus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002302 name: myocardium of atrium +def: "The atrial part of middle layer of the heart, comprised of involuntary muscle." [ISBN:0-683-40008-8, MP:0010493] +xref: EFO:0003087 +xref: EMAPA:32746 +xref: FMA:83509 +xref: MA:0000081 +xref: SCTID:191910002 +xref: TAO:0001374 +xref: VHOG:0000602 +xref: ZFA:0001374 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium @@ -35335,6 +51111,13 @@ relationship: RO:0002433 UBERON:0002081 ! cardiac atrium [Term] id: UBERON:0002308 name: nucleus of brain +def: "A neural nucleus that is part of the brain." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:35185 +xref: FMA:83840 +xref: MA:0000811 +xref: NCIT:C49346 +xref: SCTID:426465002 +xref: ZFA:0005575 is_a: UBERON:0000125 ! neural nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: BFO:0000050 UBERON:0000955 ! part of brain @@ -35343,6 +51126,16 @@ relationship: BFO:0000050 UBERON:0003528 ! part of brain gray matter [Term] id: UBERON:0002315 name: gray matter of spinal cord +def: "The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue." [MP:0008503] +xref: BAMS:Scgrey +xref: DHBA:146035048 +xref: EMAPA:35792 +xref: FMA:256580 +xref: MA:0000002 +xref: NCIT:C32696 +xref: neuronames:2619 +xref: NLXANAT:100204 +xref: SCTID:279441003 is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord @@ -35352,6 +51145,18 @@ relationship: RO:0002433 UBERON:0002240 ! spinal cord [Term] id: UBERON:0002323 name: coelemic cavity lumen +def: "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities." [BTO:0001707] +comment: EDITOR_NOTE check the FMA placement here; ncit placement of body cavity here probably not correct +xref: AEO:0000186 +xref: BTO:0001707 +xref: EHDAA2:0000267 +xref: FMA:85006 +xref: galen:BodyCavity +xref: NCIT:C25444 +xref: RETIRED_EHDAA2:0003186 +xref: SCTID:361348008 +xref: TAO:0001438 +xref: ZFA:0001438 is_a: UBERON:0002553 ! anatomical cavity relationship: RO:0002494 UBERON:0003886 ! future coelemic cavity lumen relationship: RO:0002572 UBERON:0011997 ! coelom @@ -35359,16 +51164,42 @@ relationship: RO:0002572 UBERON:0011997 ! coelom [Term] id: UBERON:0002324 name: muscle of back +def: "Any muscle organ that is part of a back [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35161 +xref: FMA:85216 +xref: MA:0000496 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005174 ! dorsal region element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0004469 ! part of musculature of back -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002328 name: notochord +def: "A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube." [http://tolweb.org/Chordata/2499, https://github.com/obophenotype/uberon/issues/25, https://github.com/obophenotype/uberon/issues/271, ISBN:0815318960, Wikipedia:Notochord] +comment: The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB] +xref: AAO:0000327 +xref: BTO:0001768 +xref: CALOHA:TS-0690 +xref: EHDAA2:0001277 +xref: EHDAA:1241 +xref: EHDAA:6021 +xref: EMAPA:16191 +xref: EV:0100002 +xref: FMA:85521 +xref: GAID:1311 +xref: http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg +xref: MAT:0000281 +xref: MESH:D009672 +xref: NCIT:C12463 +xref: SCTID:308820002 +xref: TAO:0000135 +xref: VHOG:0000199 +xref: VSAO:0000032 +xref: Wikipedia:Notochord +xref: XAO:0000055 +xref: ZFA:0000135 is_a: UBERON:0000062 ! organ is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure @@ -35386,6 +51217,26 @@ relationship: RO:0003000 PR:000014841 ! produces [Term] id: UBERON:0002329 name: somite +def: "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm." [DOI:10.1111/j.1439-0426.2012.01987.x, Wikipedia:Somite] +comment: When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248] +xref: AAO:0010569 +xref: AEO:0001015 +xref: BTO:0001558 +xref: EHDAA2:0003436 +xref: EHDAA:366 +xref: EHDAA:699 +xref: EMAPA:31169 +xref: FMA:85522 +xref: GAID:1306 +xref: MAT:0000068 +xref: MESH:D019170 +xref: MIAA:0000068 +xref: NCIT:C34302 +xref: TAO:0000155 +xref: VHOG:0000191 +xref: Wikipedia:Somite +xref: XAO:0000058 +xref: ZFA:0000155 is_a: UBERON:0005423 ! developing anatomical structure is_a: UBERON:0007503 ! epithelial vesicle relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -35394,10 +51245,20 @@ relationship: RO:0002202 UBERON:0003059 ! presomitic mesoderm [Term] id: UBERON:0002330 name: exocrine system +def: "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]." [Wikipedia:Exocrine_gland] +xref: CALOHA:TS-2057 +xref: EHDAA2:0002225 +xref: EMAPA:35329 +xref: FMA:85539 +xref: MA:0002411 +xref: NCIT:C12957 +xref: Wikipedia:Exocrine_gland +xref: WikipediaCategory:Exocrine_system is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:0002390 ! hematopoietic system disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa @@ -35407,16 +51268,29 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0002333 name: pulmonary trunk +def: "An arterial trunk which is continuous with the heart and branches into the pulmonary arteries." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0001576 +xref: EHDAA:9831 +xref: EMAPA:17015 +xref: FMA:8612 +xref: galen:PulmonaryTrunk +xref: MA:0002033 +xref: NCIT:C116918 +xref: VHOG:0001134 is_a: UBERON:0001637 ! artery relationship: BFO:0000050 UBERON:0008886 ! part of pulmonary vascular system relationship: RO:0002150 UBERON:0000948 ! heart relationship: RO:0002150 UBERON:0002080 {gci_filler="NCBITaxon:40674", gci_relation="BFO:0000050"} ! heart right ventricle relationship: RO:0002170 UBERON:0002080 ! heart right ventricle -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002338 name: lamina propria of bronchus +def: "A lamina propria that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35194 +xref: FMA:86619 +xref: MA:0001836 +xref: NCIT:C49212 is_a: UBERON:0000031 ! lamina propria of trachea is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000030 ! lamina propria @@ -35426,6 +51300,25 @@ relationship: BFO:0000050 UBERON:0000410 ! part of bronchial mucosa [Term] id: UBERON:0002342 name: neural crest +def: "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]." [MP:0009846] +comment: Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. +xref: AAO:0010578 +xref: BTO:0001764 +xref: CALOHA:TS-0676 +xref: EHDAA2:0004419 +xref: EMAPA:32737 +xref: FMA:86666 +xref: GAID:1310 +xref: MAT:0000066 +xref: MESH:D009432 +xref: MIAA:0000066 +xref: NCIT:C34222 +xref: neuronames:1366 +xref: SCTID:361462002 +xref: VHOG:0000057 +xref: Wikipedia:Neural_crest +xref: XAO:0000048 +xref: ZFA:0000045 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest is_a: UBERON:0010316 ! germ layer / neural crest @@ -35439,6 +51332,11 @@ relationship: RO:0002488 UBERON:0000110 ! neurula stage [Term] id: UBERON:0002343 name: abdomen musculature +def: "Set of all muscles in abdomen." [OBOL:automatic] +xref: FMA:71294 +xref: FMA:86917 +xref: TAO:0001327 +xref: ZFA:0001327 is_a: UBERON:0004479 ! musculature of trunk intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -35447,35 +51345,112 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0002345 name: descending thoracic aorta +def: "The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest." [MP:0009868] +xref: EFO:0002527 +xref: EMAPA:18605 +xref: FMA:87217 +xref: MA:0002572 +xref: SCTID:181301002 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0001514 ! part of descending aorta relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta relationship: RO:0002433 UBERON:0001514 ! descending aorta relationship: RO:0002433 UBERON:0001515 ! thoracic aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002346 name: neurectoderm +def: "Embryonic ectoderm that gives rise to nervous tissue." [Wikipedia:Neuroectoderm] +xref: AAO:0011074 +xref: BILA:0000039 +xref: CALOHA:TS-1212 +xref: EHDAA2:0001248 +xref: EHDAA:1498 +xref: EHDAA:255 +xref: EMAPA:16073 +xref: EV:0100004 +xref: FMA:87657 +xref: MAT:0000176 +xref: MIAA:0000176 +xref: NCIT:C34228 +xref: TAO:0001120 +xref: VHOG:0000150 +xref: Wikipedia:Neuroectoderm +xref: XAO:0000042 +xref: ZFA:0001120 is_a: UBERON:0000923 ! germ layer is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000051 CL:0000133 ! has part neurectodermal cell +[Term] +id: UBERON:0002347 +name: thoracic vertebra +def: "A thoracic vertebra endochondral element that is composed primarily of a bone tissue." [OBOL:automatic] +xref: EMAPA:18011 +xref: FMA:9139 +xref: GAID:244 +xref: MA:0000314 +xref: MESH:D013904 +xref: NCIT:C12798 +xref: SCTID:181821009 +xref: Wikipedia:Thoracic_vertebrae +is_a: UBERON:0002412 ! vertebra +is_a: UBERON:0003827 ! thoracic segment bone +is_a: UBERON:0004247 ! bone of dorsum +is_a: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002481 ! bone tissue +relationship: RO:0002202 UBERON:0013507 ! thoracic vertebra cartilage element + [Term] id: UBERON:0002348 name: epicardium +def: "A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart." [http://orcid.org/0000-0002-6601-2165] +comment: EDITOR_NOTE TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer. +xref: AAO:0010409 +xref: EHDAA2:0002202 +xref: FMA:9461 +xref: galen:Epicardium +xref: NCIT:C13164 +xref: TAO:0005057 +xref: VHOG:0000119 +xref: Wikipedia:Epicardium +xref: XAO:0000316 +xref: ZFA:0005057 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0002425 ! part of visceral serous pericardium relationship: RO:0002202 UBERON:0004160 ! proepicardium relationship: RO:0002371 UBERON:0002349 ! myocardium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002349 name: myocardium +def: "The middle layer of the heart, comprised mainly of striated cardiac muscle fibers." [ISBN:0-683-40008-8, MP:0005329] +comment: EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium +xref: AAO:0010410 +xref: BSA:0000089 +xref: BTO:0000901 +xref: CALOHA:TS-0440 +xref: EFO:0000819 +xref: EHDAA2:0004150 +xref: EV:0100022 +xref: FMA:9462 +xref: GAID:173 +xref: galen:Myocardium +xref: MA:0000164 +xref: MAT:0000453 +xref: MESH:D009206 +xref: NCIT:C12371 +xref: RETIRED_EHDAA2:0001220 +xref: SCTID:362012001 +xref: TAO:0001319 +xref: VHOG:0000083 +xref: Wikipedia:Myocardium +xref: XAO:0000065 +xref: ZFA:0001319 is_a: UBERON:0005983 ! heart layer is_a: UBERON:0018260 ! layer of muscle tissue intersection_of: UBERON:0005983 ! heart layer @@ -35487,6 +51462,18 @@ relationship: RO:0002473 UBERON:0001133 ! cardiac muscle tissue [Term] id: UBERON:0002350 name: conducting system of heart +def: "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]." [GO:0003161] +xref: EFO:0003909 +xref: EHDAA2:0004185 +xref: EMAPA:35428 +xref: EV:0100025 +xref: FMA:9476 +xref: MA:0000094 +xref: MESH:D006329 +xref: SCTID:281489000 +xref: TAO:0005063 +xref: VHOG:0001271 +xref: ZFA:0005063 is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 ! conducting tissue of heart relationship: BFO:0000051 CL:0002068 ! has part Purkinje myocyte @@ -35499,6 +51486,20 @@ relationship: RO:0002433 UBERON:0000948 ! heart [Term] id: UBERON:0002351 name: sinoatrial node +def: "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]." [GO:0003163, Wikipedia:Sinoatrial_node] +comment: WP:Heart states: "The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.". Note however that ZFA has SA node. +xref: BTO:0004358 +xref: EHDAA2:0004184 +xref: EMAPA:35772 +xref: FMA:9477 +xref: GAID:561 +xref: MA:0000097 +xref: MESH:D012849 +xref: NCIT:C33555 +xref: SCTID:277687007 +xref: TAO:0005069 +xref: Wikipedia:Sinoatrial_node +xref: ZFA:0005069 is_a: UBERON:0003379 ! cardiac muscle of right atrium is_a: UBERON:0010131 ! conducting tissue of heart relationship: BFO:0000050 UBERON:0002350 ! part of conducting system of heart @@ -35506,11 +51507,26 @@ relationship: RO:0002162 NCBITaxon:7742 ! Vertebrata relationship: RO:0002215 GO:0002027 ! capable of regulation of heart rate relationship: RO:0002216 GO:0060048 ! capable of part of cardiac muscle contraction relationship: RO:0002433 UBERON:0002350 ! conducting system of heart -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002352 name: atrioventricular node +def: "An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles." [UBERON:cjm, Wikipedia:Atrioventricular_node] +xref: BTO:0005689 +xref: EFO:0000276 +xref: EHDAA2:0004183 +xref: EMAPA:35153 +xref: FMA:9478 +xref: GAID:558 +xref: MA:0000095 +xref: MAT:0000498 +xref: MESH:D001283 +xref: NCIT:C32161 +xref: SCTID:277688002 +xref: TAO:0005070 +xref: VHOG:0001474 +xref: Wikipedia:Atrioventricular_node +xref: ZFA:0005070 is_a: UBERON:0004491 ! cardiac muscle tissue of interatrial septum is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium is_a: UBERON:0010131 ! conducting tissue of heart @@ -35518,11 +51534,19 @@ relationship: BFO:0000050 UBERON:0002350 ! part of conducting system of heart relationship: RO:0002170 UBERON:0002085 ! interatrial septum relationship: RO:0002170 UBERON:0005979 ! crista terminalis relationship: RO:0002433 UBERON:0002350 ! conducting system of heart -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002354 name: cardiac Purkinje fiber +def: "The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GO:0003165] +xref: BTO:0001735 +xref: EMAPA:35718 +xref: FMA:9492 +xref: GAID:560 +xref: MA:0000096 +xref: MESH:D011690 +xref: NCIT:C33430 +xref: Wikipedia:Purkinje_fiber is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BFO:0000050 UBERON:8000009 ! part of Purkinje fiber network @@ -35532,6 +51556,12 @@ relationship: RO:0002433 UBERON:0002350 ! conducting system of heart [Term] id: UBERON:0002357 name: serous pericardium +def: "Serous membrane which is divided into parietal and visceral serous pericardium." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Serous_pericardium] +xref: EMAPA:19030 +xref: FMA:9582 +xref: MA:0002739 +xref: SCTID:243954002 +xref: Wikipedia:Serous_pericardium is_a: UBERON:0000042 ! serous membrane relationship: BFO:0000050 UBERON:0002406 ! part of pericardial sac relationship: BFO:0000051 UBERON:0002408 ! has part parietal serous pericardium @@ -35541,6 +51571,22 @@ relationship: RO:0002371 UBERON:0002359 ! fibrous pericardium [Term] id: UBERON:0002358 name: peritoneum +def: "A serous membrane that lines the peritoneal cavity[VHOG,modified]." [VHOG:0001257] +xref: AAO:0010814 +xref: BTO:0001472 +xref: CALOHA:TS-2072 +xref: EV:0100087 +xref: FMA:9584 +xref: GAID:18 +xref: galen:Peritoneum +xref: MA:0000449 +xref: MESH:D010537 +xref: NCIT:C12770 +xref: TAO:0005120 +xref: VHOG:0001257 +xref: Wikipedia:Peritoneum +xref: XAO:0000139 +xref: ZFA:0005120 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0035820 ! part of peritoneal sac @@ -35550,6 +51596,12 @@ relationship: BFO:0000050 UBERON:0035820 ! part of peritoneal sac [Term] id: UBERON:0002359 name: fibrous pericardium +def: "Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]." [FMA:9586] +xref: EMAPA:19029 +xref: FMA:9586 +xref: MA:0002738 +xref: SCTID:243953008 +xref: Wikipedia:Fibrous_pericardium is_a: UBERON:0000094 ! membrane organ is_a: UBERON:0005181 ! thoracic segment organ relationship: BFO:0000050 UBERON:0002407 ! part of pericardium @@ -35559,6 +51611,19 @@ relationship: RO:0002473 UBERON:0006815 ! areolar connective tissue [Term] id: UBERON:0002365 name: exocrine gland +def: "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas." [Wikipedia:Exocrine_gland] +xref: AEO:0000097 +xref: BTO:0000765 +xref: CALOHA:TS-2012 +xref: EHDAA2:0003097 +xref: EMAPA:35327 +xref: FMA:9596 +xref: GAID:34 +xref: MA:0002564 +xref: MESH:D005088 +xref: NCIT:C12712 +xref: SCTID:115976003 +xref: Wikipedia:Exocrine_gland is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002330 ! part of exocrine system @@ -35568,6 +51633,19 @@ relationship: BFO:0000051 UBERON:0000058 ! has part duct [Term] id: UBERON:0002368 name: endocrine gland +def: "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]." [Wikipedia:Endocrine_gland] +xref: AEO:0000098 +xref: BTO:0001488 +xref: CALOHA:TS-1300 +xref: EHDAA2:0003098 +xref: EMAPA:35999 +xref: FMA:9602 +xref: GAID:335 +xref: MA:0002563 +xref: MESH:D004702 +xref: NCIT:C12704 +xref: SCTID:40818001 +xref: Wikipedia:Endocrine_gland is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000949 ! part of endocrine system @@ -35577,6 +51655,26 @@ relationship: RO:0002215 GO:0046879 ! capable of hormone secretion [Term] id: UBERON:0002371 name: bone marrow +def: "The soft tissue that fills the cavities of bones." [MGI:cwg, MP:0002397] +xref: AAO:0011007 +xref: BTO:0000141 +xref: BTO:0000829 +xref: CALOHA:TS-0087 +xref: EFO:0000868 +xref: EMAPA:32760 +xref: EV:0100046 +xref: FMA:9608 +xref: GAID:1287 +xref: galen:BoneMarrow +xref: MA:0000134 +xref: MAT:0000084 +xref: MESH:D001853 +xref: MIAA:0000084 +xref: NCIT:C12431 +xref: SCTID:421320006 +xref: VHOG:0001218 +xref: Wikipedia:Bone_marrow +xref: XAO:0000123 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000479 ! tissue @@ -35587,11 +51685,21 @@ relationship: BFO:0000050 UBERON:0002390 ! part of hematopoietic system relationship: BFO:0000050 UBERON:0002405 ! part of immune system relationship: BFO:0000051 CL:0002092 ! has part bone marrow cell relationship: BFO:0000051 UBERON:0012429 ! has part hematopoietic tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002376 name: cranial muscle +def: "Any skeletal muscle that is part of the head region." [http://orcid.org/0000-0002-6601-2165] +comment: defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984) +xref: AAO:0000107 +xref: BTO:0000021 +xref: EFO:0003524 +xref: EHDAA2:0000322 +xref: EMAPA:18172 +xref: FMA:9616 +xref: MA:0000578 +xref: SCTID:244718003 +xref: ZFA:0001652 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010959 ! craniocervical muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate @@ -35600,38 +51708,83 @@ intersection_of: RO:0002371 UBERON:0003129 ! skull relationship: BFO:0000050 UBERON:0004461 ! part of skeletal musculature of head relationship: RO:0002202 UBERON:0006904 ! head mesenchyme from mesoderm relationship: RO:0002371 UBERON:0003129 ! skull -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002377 name: muscle of neck +def: "Any muscle that is part of the cervical (neck) region." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:9617 +xref: GAID:149 +xref: MA:0000587 +xref: MESH:D009334 +xref: NCIT:C33163 is_a: UBERON:0010959 ! craniocervical muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0004465 ! part of musculature of neck -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002378 name: muscle of abdomen +def: "Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis." [Wikipedia:Abdominal_muscle] +xref: BTO:0001261 +xref: EMAPA:35103 +xref: FMA:9620 +xref: GAID:89 +xref: MA:0000520 +xref: MESH:D000009 +xref: NCIT:C32040 +xref: SCTID:361352008 +xref: Wikipedia:Abdominal_muscle is_a: UBERON:0003833 ! abdominal segment muscle is_a: UBERON:0005172 ! abdomen element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0002343 ! part of abdomen musculature relationship: BFO:0000050 UBERON:0003697 ! part of abdominal wall -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002384 name: connective tissue +def: "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/23, PSPUB:0000170, VSAO:0000017] +xref: AAO:0000098 +xref: BTO:0000421 +xref: CALOHA:TS-2009 +xref: EFO:0000952 +xref: EMAPA:35251 +xref: FMA:9640 +xref: GAID:100 +xref: galen:ConnectiveTissue +xref: MA:0000011 +xref: MAT:0000301 +xref: MESH:D003238 +xref: MIAA:0000301 +xref: NCIT:C12374 +xref: SCTID:361919005 +xref: TAO:0001641 +xref: VSAO:0000017 +xref: XAO:0001017 +xref: ZFA:0001632 is_a: UBERON:0000479 ! tissue relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002385 name: muscle tissue +def: "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]." [GO:0060537, https://sourceforge.net/tracker/index.php?func=detail&aid=2801266&group_id=36855&atid=440764, Wikipedia:Muscle_tissue] +comment: Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach. +xref: AAO:0000306 +xref: AEO:0000122 +xref: CALOHA:TS-0642 +xref: EHDAA2:0003122 +xref: EMAPA:32715 +xref: FMA:9641 +xref: galen:MuscleTissue +xref: MA:0002437 +xref: MESH:D009132 +xref: NCIT:C12435 +xref: SCTID:91727004 +xref: Wikipedia:Muscle_tissue is_a: UBERON:0000479 ! tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000479 ! tissue @@ -35645,20 +51798,97 @@ relationship: RO:0002473 CL:0000187 ! muscle cell [Term] id: UBERON:0002390 name: hematopoietic system +def: "Anatomical system that is involved in the production of hematopoietic cells." [Wikipedia:Haematopoiesis] +xref: AAO:0011002 +xref: BTO:0000570 +xref: CALOHA:TS-0449 +xref: EFO:0000798 +xref: EMAPA:35402 +xref: EV:0100045 +xref: FMA:9667 +xref: GAID:1008 +xref: MA:0002434 +xref: MAT:0000022 +xref: MESH:D006413 +xref: MIAA:0000022 +xref: NCIT:C12909 +xref: SCTID:362587009 +xref: TAO:0005023 +xref: VHOG:0001624 +xref: Wikipedia:Haematopoiesis +xref: XAO:0000122 +xref: ZFA:0005023 is_a: UBERON:0000467 ! anatomical system is_a: UBERON:0004120 ! mesoderm-derived structure disjoint_from: UBERON:0002405 ! immune system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system relationship: RO:0002160 NCBITaxon:7711 ! Chordata relationship: RO:0002202 UBERON:0003061 ! blood island -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002394 +name: bile duct +def: "Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Bile_duct] +xref: AAO:0011019 +xref: BTO:0000122 +xref: CALOHA:TS-0075 +xref: EMAPA:35171 +xref: EV:0100091 +xref: FMA:9706 +xref: GAID:280 +xref: MA:0000354 +xref: MESH:D001652 +xref: NCIT:C12376 +xref: SCTID:276157007 +xref: TAO:0001100 +xref: VHOG:0000212 +xref: Wikipedia:Bile_duct +xref: XAO:0000134 +xref: ZFA:0001100 +is_a: UBERON:0000025 ! tube +is_a: UBERON:0003928 ! digestive system duct +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000058 ! duct +intersection_of: BFO:0000050 UBERON:0001173 ! part of biliary tree +relationship: BFO:0000050 UBERON:0001173 ! part of biliary tree +relationship: channel_for UBERON:0001970 ! bile +relationship: RO:0002202 UBERON:0008835 ! hepatic diverticulum +relationship: RO:0002433 UBERON:0001173 ! biliary tree + +[Term] +id: UBERON:0002396 +name: vomer +def: "The triangular flat bone of the nasal septum." [ISBN:0-683-40008-8, MP:0000098] +xref: AAO:0000633 +xref: FMA:9710 +xref: MA:0001496 +xref: NCIT:C33888 +xref: SCTID:272678009 +xref: TAO:0000308 +xref: Wikipedia:Vomer +xref: ZFA:0000308 +is_a: UBERON:0008001 ! irregular bone +is_a: UBERON:0011597 ! bone of upper jaw +is_a: UBERON:0012071 ! palate bone +relationship: BFO:0000050 UBERON:0011085 ! part of palatoquadrate arch +relationship: RO:0002433 UBERON:0011156 ! facial skeleton [Term] id: UBERON:0002400 name: parietal pleura +def: "The outer serous membrane of the pulmonary pleural." [UBERON:cjm, Wikipedia:Pulmonary_pleurae] +comment: the part of the pleura external to the visceral pleura. It lines the inner surface of the chest wall, covers the diaphragm, and is reflected over the structures occupying the middle of the thorax +xref: EMAPA:16776 +xref: FMA:9733 +xref: MA:0002488 +xref: NCIT:C33273 +xref: SCTID:361998003 +xref: VHOG:0001495 +xref: Wikipedia:Parietal_pleura is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -35672,6 +51902,14 @@ relationship: RO:0002433 UBERON:0000977 ! pleura [Term] id: UBERON:0002401 name: visceral pleura +def: "The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs." [UBERON:cjm, Wikipedia:Pulmonary_pleurae] +xref: EHDAA2:0002205 +xref: EMAPA:16777 +xref: FMA:9734 +xref: MA:0002489 +xref: NCIT:C33881 +xref: SCTID:361997008 +xref: VHOG:0001496 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0004923 ! organ component layer @@ -35682,11 +51920,23 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002220 UBERON:0002048 ! adjacent to lung relationship: RO:0002371 UBERON:0008946 ! lung parenchyma relationship: RO:0002433 UBERON:0000977 ! pleura -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002402 name: pleural cavity +def: "The fluid-filled cavity that lies between the visceral and parietal pleurae." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Pleural_cavity] +xref: BTO:0004422 +xref: EHDAA2:0001475 +xref: EMAPA:16773 +xref: EMAPA:16774 +xref: FMA:9740 +xref: GAID:95 +xref: MA:0000055 +xref: MESH:D035422 +xref: NCIT:C12840 +xref: SCTID:361999006 +xref: VHOG:0000581 +xref: Wikipedia:Pleural_cavity is_a: UBERON:0035809 ! serous cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0009778 ! pleural sac @@ -35698,18 +51948,37 @@ relationship: RO:0002572 UBERON:0009778 ! pleural sac [Term] id: UBERON:0002405 name: immune system +def: "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies." [Wikipedia:Immune_system] +xref: AAO:0011003 +xref: BILA:0000104 +xref: BTO:0005810 +xref: FMA:9825 +xref: GAID:328 +xref: MA:0002711 +xref: MESH:D007107 +xref: NCIT:C12735 +xref: SCTID:362590003 +xref: TAO:0001159 +xref: VHOG:0001247 +xref: Wikipedia:Immune_system +xref: XAO:0003152 +xref: ZFA:0001159 is_a: UBERON:0015203 ! non-connected functional system disjoint_from: UBERON:0002416 ! integumental system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: protects UBERON:0000468 ! multicellular organism relationship: RO:0002215 GO:0002376 ! capable of immune system process relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002406 name: pericardial sac +def: "A double-walled sac containing the heart and the roots of the great vessels." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Pericardium] +xref: FMA:9868 +xref: RETIRED_EHDAA2:0001443 +xref: SCTID:361326002 is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0005906 ! serous sac intersection_of: UBERON:0005906 ! serous sac @@ -35723,16 +51992,46 @@ relationship: RO:0002219 UBERON:0002359 ! fibrous pericardium [Term] id: UBERON:0002407 name: pericardium +def: "The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Pericardium] +xref: AAO:0010817 +xref: BSA:0000090 +xref: BTO:0000717 +xref: CALOHA:TS-0761 +xref: EFO:0000820 +xref: EHDAA:5376 +xref: EV:0100023 +xref: FMA:9869 +xref: GAID:569 +xref: galen:Pericardium +xref: MA:0000099 +xref: MAT:0000454 +xref: MESH:D010496 +xref: NCIT:C13005 +xref: RETIRED_EHDAA2:0001443 +xref: SCTID:181295003 +xref: VHOG:0001280 +xref: Wikipedia:Pericardium +xref: XAO:0004182 +xref: ZFA:0000054 is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0015410 ! part of heart plus pericardium relationship: BFO:0000051 UBERON:0002359 ! has part fibrous pericardium relationship: BFO:0000051 UBERON:0002406 ! has part pericardial sac relationship: RO:0002221 UBERON:0002349 ! myocardium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002408 name: parietal serous pericardium +def: "Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA:3422 +xref: EHDAA:5378 +xref: EMAPA:19031 +xref: FMA:9870 +xref: MA:0000483 +xref: NCIT:C94500 +xref: SCTID:243956000 +xref: VHOG:0000537 +xref: Wikipedia:Parietal_pericardium is_a: UBERON:0022351 ! parietal serous membrane intersection_of: UBERON:0022351 ! parietal serous membrane intersection_of: BFO:0000050 UBERON:0002357 ! part of serous pericardium @@ -35741,6 +52040,11 @@ relationship: BFO:0000050 UBERON:0002357 ! part of serous pericardium [Term] id: UBERON:0002409 name: pericardial fluid +def: "Transudate contained in the pericardial cavity.[FMA]." [FMA:9887, Wikipedia:Pericardial_fluid] +xref: BTO:0001016 +xref: FMA:9887 +xref: MA:0002530 +xref: Wikipedia:Pericardial_fluid is_a: UBERON:0007794 ! secretion of serous gland is_a: UBERON:0036217 ! coelomic fluid intersection_of: UBERON:0000463 ! organism substance @@ -35751,32 +52055,173 @@ relationship: RO:0003001 UBERON:0002425 ! produced by visceral serous pericardiu [Term] id: UBERON:0002410 name: autonomic nervous system +def: "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]." [GO:0048483] +xref: AAO:0000033 +xref: BIRNLEX:1123 +xref: BTO:0002507 +xref: CALOHA:TS-2001 +xref: EHDA:10095 +xref: EHDAA2:0000158 +xref: EHDAA:3767 +xref: EMAPA:16984 +xref: FMA:65553 +xref: GAID:706 +xref: MA:0000219 +xref: MESH:D001341 +xref: NCIT:C12673 +xref: neuronames:2054 +xref: SCTID:362481007 +xref: TAO:0001574 +xref: VHOG:0000396 +xref: Wikipedia:Autonomic_nervous_system +xref: ZFA:0001574 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002433 UBERON:0001016 ! nervous system +[Term] +id: UBERON:0002412 +name: vertebra +def: "The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, http://orcid.org/0000-0002-6601-2165, VSAO:0000184] +xref: AAO:0000691 +xref: CALOHA:TS-2352 +xref: EFO:0001371 +xref: EMAPA:32740 +xref: FMA:9914 +xref: galen:Vertebra +xref: MA:0000309 +xref: NCIT:C12933 +xref: SCTID:181817002 +xref: TAO:0001189 +xref: Wikipedia:Vertebra +xref: XAO:0004019 +xref: ZFA:0001189 +is_a: UBERON:0002513 ! endochondral bone +is_a: UBERON:0008001 ! irregular bone +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: RO:0002473 UBERON:0002481 ! bone tissue +relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column +relationship: RO:0002202 UBERON:0011094 ! vertebra cartilage element + +[Term] +id: UBERON:0002413 +name: cervical vertebra +def: "A vertebra that is located in the cervical region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:17674 +xref: FMA:9915 +xref: GAID:235 +xref: galen:CervicalVertebra +xref: MA:0000311 +xref: MESH:D002574 +xref: NCIT:C12693 +xref: SCTID:181820005 +xref: Wikipedia:Cervical_vertebrae +xref: XAO:0003076 +is_a: UBERON:0003458 ! neck bone +is_a: UBERON:0004247 ! bone of dorsum +is_a: UBERON:0004451 ! trunk or cervical vertebra +is_a: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002481 ! bone tissue +relationship: RO:0002202 UBERON:0013505 ! cervical vertebra cartilage element + +[Term] +id: UBERON:0002415 +name: tail +def: "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail." [AEO:0000109, Wikipedia:Tail] +xref: AEO:0000109 +xref: BILA:0000117 +xref: BTO:0001348 +xref: EFO:0000963 +xref: EHDAA:9198 +xref: GAID:1245 +xref: MAT:0000094 +xref: MESH:D013623 +xref: MIAA:0000094 +xref: WBbt:0005741 +xref: Wikipedia:Tail +is_a: UBERON:0011676 ! subdivision of organism along main body axis +relationship: BFO:0000050 UBERON:0000154 ! part of posterior region of body +relationship: RO:0002160 NCBITaxon:33213 ! Bilateria + [Term] id: UBERON:0002416 name: integumental system +def: "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle." [CARO:0002001, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/29] +xref: AEO:0000154 +xref: BILA:0000118 +xref: CALOHA:TS-1299 +xref: CARO:0002001 +xref: EFO:0000807 +xref: EHDAA2:0000836 +xref: EHDAA2_RETIRED:0003154 +xref: EHDAA:6520 +xref: EMAPA:17524 +xref: EV:0100151 +xref: FMA:72979 +xref: galen:Surface +xref: HAO:0000421 +xref: MA:0000014 +xref: MAT:0000033 +xref: MESH:D034582 +xref: MIAA:0000033 +xref: NCIT:C12907 +xref: SCTID:361692004 +xref: TADS:0000108 +xref: VHOG:0000403 +xref: Wikipedia:Integumentary_system +xref: XAO:0000176 is_a: UBERON:0000467 ! anatomical system +disjoint_from: UBERON:0002423 ! hepatobiliary system disjoint_from: UBERON:0004456 ! entire sense organ system disjoint_from: UBERON:8450002 ! excretory system relationship: BFO:0000051 UBERON:0007376 ! has part outer epithelium relationship: RO:0002007 UBERON:0000468 ! bounding layer of multicellular organism relationship: RO:0002219 UBERON:0013514 ! space surrounding organism relationship: RO:0002492 UBERON:0000066 ! fully formed stage -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002417 name: abdominal segment of trunk +def: "The abdominal segment of the torso." [Wikipedia:Lumbar] +xref: EMAPA:35104 +xref: FMA:259211 +xref: MA:0000021 +xref: SCTID:362875007 +xref: Wikipedia:Lumbar is_a: UBERON:0009569 ! subdivision of trunk is_a: UBERON:0011676 ! subdivision of organism along main body axis [Term] id: UBERON:0002418 name: cartilage tissue +def: "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/37, https://sourceforge.net/p/obo/vertebrate-skeletal-anatomy-vsao-term-requests/5, PSPUB:0000170, VSAO:0000040] +comment: Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W] +xref: AAO:0000060 +xref: AEO:0000087 +xref: BTO:0000206 +xref: EFO:0000949 +xref: EHDAA2:0003087 +xref: EMAPA:32730 +xref: EV:0100141 +xref: FMA:37377 +xref: GAID:99 +xref: galen:Cartilage +xref: MA:0000104 +xref: MAT:0000189 +xref: MESH:D002356 +xref: MIAA:0000189 +xref: NCIT:C12373 +xref: NCIT:C32268 +xref: SCTID:309312004 +xref: TAO:0001501 +xref: VHOG:0001207 +xref: VSAO:0000040 +xref: Wikipedia:Cartilage +xref: XAO:0000170 +xref: ZFA:0005622 is_a: UBERON:0004755 ! skeletal tissue relationship: BFO:0000051 CHEBI:18085 ! has part relationship: BFO:0000051 CL:0000138 ! has part chondrocyte @@ -35786,6 +52231,11 @@ relationship: RO:0002433 UBERON:0001434 ! skeletal system [Term] id: UBERON:0002419 name: skin gland +def: "A gland that is part of a skin of body [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35774 +xref: FMA:71878 +xref: MA:0000146 +xref: SCTID:110485007 is_a: UBERON:0003297 ! gland of integumental system is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0006003 ! integumentary adnexa @@ -35793,9 +52243,54 @@ intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body relationship: BFO:0000050 UBERON:0002097 ! part of skin of body +[Term] +id: UBERON:0002423 +name: hepatobiliary system +def: "The part of the digestive system that contains the liver and the biliary system." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0011056 +xref: CALOHA:TS-1308 +xref: EFO:0000800 +xref: EHDAA2:0000998 +xref: EHDAA:2189 +xref: EMAPA:16840 +xref: EV:0100088 +xref: MA:0000324 +xref: MAT:0000024 +xref: MIAA:0000024 +xref: NCIT:C43612 +xref: TAO:0000036 +xref: VHOG:0000294 +xref: Wikipedia:Hepatobiliary_system +xref: XAO:0000132 +xref: ZFA:0000036 +is_a: UBERON:0011216 ! organ system subdivision +disjoint_from: UBERON:0004456 ! entire sense organ system +disjoint_from: UBERON:8450002 ! excretory system +relationship: BFO:0000050 UBERON:0001007 ! part of digestive system +relationship: BFO:0000051 UBERON:0002107 ! has part liver +relationship: BFO:0000051 UBERON:0002294 ! has part biliary system +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002215 GO:0061007 ! capable of hepaticobiliary system process +relationship: RO:0002492 UBERON:0000066 ! fully formed stage + [Term] id: UBERON:0002424 name: oral epithelium +def: "An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0010357 +xref: BTO:0001775 +xref: CALOHA:TS-0715 +xref: EHDAA2:0001325 +xref: EHDAA:2187 +xref: EMAPA:16839 +xref: EMAPA:26942 +xref: FMA:265152 +xref: MA:0000344 +xref: NCIT:C49595 +xref: TAO:0000816 +xref: VHOG:0000187 +xref: XAO:0003201 +xref: ZFA:0000816 is_a: UBERON:0003350 ! epithelium of mucosa is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium @@ -35806,6 +52301,13 @@ relationship: RO:0002220 UBERON:0000167 ! adjacent to oral cavity [Term] id: UBERON:0002425 name: visceral serous pericardium +def: "Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]." [Wikipedia:Visceral_pericardium] +xref: EMAPA:19032 +xref: FMA:84882 +xref: MA:0000484 +xref: SCTID:243955001 +xref: VHOG:0000538 +xref: Wikipedia:Visceral_pericardium is_a: UBERON:0022350 ! visceral serous membrane intersection_of: UBERON:0022350 ! visceral serous membrane intersection_of: BFO:0000050 UBERON:0002357 ! part of serous pericardium @@ -35817,6 +52319,11 @@ relationship: RO:0002433 UBERON:0002407 ! pericardium [Term] id: UBERON:0002443 name: choroidal blood vessel +def: "A blood vessel that is part of a choroid [Automatically generated definition]." [OBOL:automatic] +comment: cannot find singular in FMA, using Set class +xref: EMAPA:17828 +xref: FMA:76550 +xref: MA:0001237 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001981 ! blood vessel @@ -35826,20 +52333,63 @@ relationship: BFO:0000050 UBERON:0001776 ! part of optic choroid [Term] id: UBERON:0002457 name: intersomitic artery +def: "The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries." [MP:0010662] +xref: EHDAA2:0000882 +xref: EHDAA:4340 +xref: EMAPA:17616 +xref: MA:0001985 +xref: SCTID:360401001 +xref: TAO:0001061 +xref: VHOG:0000225 +xref: XAO:0004165 +xref: ZFA:0001061 is_a: UBERON:0001637 ! artery is_a: UBERON:0014907 ! intersomitic vessel [Term] id: UBERON:0002458 name: spinal artery +def: "Arteries that supply the spinal cord." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Spinal_artery] +xref: EHDAA2:0001890 +xref: EHDAA:4355 +xref: EMAPA:18241 +xref: MA:0002043 +xref: NCIT:C33587 +xref: SCTID:244228006 +xref: TAO:0000682 +xref: Wikipedia:Spinal_artery +xref: ZFA:0000682 is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0002240 ! spinal cord relationship: RO:0002178 UBERON:0002240 ! spinal cord +[Term] +id: UBERON:0002466 +name: intestine secretion +def: "Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine." [Wikipedia:Succus_entericus] +xref: BTO:0000644 +xref: FMA:62974 +xref: GAID:1162 +xref: MA:0002515 +xref: MESH:D007419 +xref: NCIT:C32875 +xref: Wikipedia:Succus_entericus +is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: RO:0003001 UBERON:0000160 ! produced by intestine +relationship: RO:0003001 UBERON:0000160 ! produced by intestine + [Term] id: UBERON:0002469 name: esophagus mucosa +def: "A mucosa that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0002859 +xref: EMAPA:26981 +xref: FMA:62996 +xref: MA:0002680 +xref: NCIT:C32538 +xref: SCTID:362127004 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus @@ -35848,6 +52398,18 @@ relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus [Term] id: UBERON:0002481 name: bone tissue +def: "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000047] +xref: CALOHA:TS-2011 +xref: EMAPA:35179 +xref: FMA:224804 +xref: galen:BoneTissue +xref: MA:0002780 +xref: MESH:D001842 +xref: NCIT:C13076 +xref: VSAO:0000047 +xref: Wikipedia:Bone_tissue +xref: XAO:0004040 +xref: ZFA:0005621 is_a: UBERON:0004755 ! skeletal tissue disjoint_from: UBERON:0005090 ! muscle structure relationship: BFO:0000050 UBERON:0001474 ! part of bone element @@ -35856,6 +52418,10 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0002506 name: iris epithelium +def: "An epithelium that is part of a iris [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35447 +xref: FMA:58517 +xref: MA:0002826 is_a: UBERON:0000488 ! atypical epithelium is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium @@ -35863,11 +52429,34 @@ intersection_of: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000050 UBERON:0001769 ! part of iris relationship: BFO:0000051 GO:0048770 ! has part pigment granule relationship: RO:0002433 UBERON:0001769 ! iris -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0002511 +name: trabecula carnea +def: "The supporting bundles of muscular fibers lining the walls of the ventricles of the heart." [MGI:monikat, MP:0004067] +xref: EMAPA:18626 +xref: FMA:7269 +xref: MA:0002831 +xref: SCTID:118755002 +xref: Wikipedia:Trabeculae_carneae +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0004120 ! mesoderm-derived structure +relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle +relationship: RO:0002473 UBERON:0001133 ! cardiac muscle tissue [Term] id: UBERON:0002513 name: endochondral bone +def: "Replacement bone that forms within cartilage." [GO:0001958, GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/54, VSAO:0000145] +xref: AAO:0010776 +xref: AEO:0000083 +xref: BTO:0002157 +xref: EHDAA2:0003083 +xref: FMA:24321 +xref: TAO:0001591 +xref: VSAO:0000145 +xref: XAO:0004018 +xref: ZFA:0001591 is_a: UBERON:0001474 ! bone element is_a: UBERON:0010363 ! endochondral element intersection_of: UBERON:0001474 ! bone element @@ -35879,13 +52468,43 @@ relationship: RO:0002285 UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0002514 name: intramembranous bone +def: "Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]." [GO:0001957, https://github.com/obophenotype/uberon/issues/267, Wikipedia:Intramembranous_ossification] +xref: EMAPA:36615 +xref: TAO:0001644 +xref: Wikipedia:Intramembranous_ossification +xref: ZFA:0001635 is_a: UBERON:0001474 ! bone element relationship: RO:0002202 UBERON:0003104 ! mesenchyme relationship: RO:0002353 GO:0001957 ! output of intramembranous ossification +[Term] +id: UBERON:0002517 +name: basicranium +def: "The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof." [Wikipedia:Base_of_skull] +comment: The skull base is formed from a series of cartilages either side of, and rostral to, the notochord, whose tip lies just caudal to the pituitary gland. It is closely associated with the sensory capsules, which partially or completely sur- round the olfactory epithelium, the eye, and the inner ear[PMID:11523816] +xref: FMA:52801 +xref: MA:0002840 +xref: MESH:D019291 +xref: MFMO:0000044 +xref: NCIT:C12493 +xref: SCTID:181890004 +xref: Wikipedia:Base_of_skull +is_a: UBERON:0000075 ! subdivision of skeletal system +relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium +relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium +relationship: RO:0002433 UBERON:0003128 ! cranium + [Term] id: UBERON:0002521 name: elastic tissue +def: "Connective tissue composed of elastic fibers." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:20113 +xref: GAID:926 +xref: MA:0002853 +xref: MESH:D004547 +xref: NCIT:C32495 +xref: SCTID:27197004 +xref: Wikipedia:Elastic_fiber is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002473 GO:0071953 ! elastic fiber @@ -35895,6 +52514,17 @@ relationship: RO:0002473 GO:0071953 ! elastic fiber [Term] id: UBERON:0002522 name: tunica media +def: "The middle layer of an artery or vein. [WP,unvetted]." [Wikipedia:Tunica_media] +comment: May be composed of smooth muscle and elastic tissue +xref: BTO:0002011 +xref: EMAPA:36298 +xref: FMA:55590 +xref: GAID:170 +xref: MA:0002855 +xref: MESH:D017540 +xref: NCIT:C33821 +xref: SCTID:61695000 +xref: Wikipedia:Tunica_media is_a: UBERON:0004797 ! blood vessel layer relationship: BFO:0000051 UBERON:0002521 ! has part elastic tissue relationship: BFO:0000051 UBERON:0004237 ! has part blood vessel smooth muscle @@ -35903,6 +52533,17 @@ relationship: RO:0002219 UBERON:0005734 ! tunica adventitia of blood vessel [Term] id: UBERON:0002523 name: tunica intima +def: "The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]." [ISBN:0073040584, NCIT:C33820, Wikipedia:Tunica_intima] +xref: BTO:0002012 +xref: EMAPA:36297 +xref: FMA:55589 +xref: GAID:523 +xref: MA:0002861 +xref: MESH:D017539 +xref: NCIT:C33820 +xref: SCTID:8361002 +xref: SCTID:87483006 +xref: Wikipedia:Tunica_intima is_a: UBERON:0004923 ! organ component layer relationship: BFO:0000051 UBERON:0001986 ! has part endothelium relationship: RO:0002219 UBERON:0002522 ! tunica media @@ -35911,6 +52552,25 @@ relationship: RO:0002220 UBERON:0010161 ! adjacent to lumen of blood vessel [Term] id: UBERON:0002530 name: gland +def: "An organ that functions as a secretory or excretory organ." [MGI:csmith, MP:0002163] +xref: AAO:0000212 +xref: AEO:0000096 +xref: BTO:0000522 +xref: EFO:0000797 +xref: EHDAA2:0003096 +xref: EHDAA:2161 +xref: EMAPA:18425 +xref: FMA:7146 +xref: FMA:86294 +xref: galen:Gland +xref: HAO:0000375 +xref: MA:0003038 +xref: MAT:0000021 +xref: MIAA:0000021 +xref: NCIT:C13319 +xref: SCTID:134358001 +xref: Wikipedia:Gland +xref: WikipediaCategory:Glands is_a: UBERON:0000062 ! organ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa relationship: RO:0002215 GO:0046903 ! capable of secretion @@ -35919,12 +52579,46 @@ relationship: RO:0003000 UBERON:0000463 ! produces organism substance [Term] id: UBERON:0002532 name: epiblast (generic) +def: "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]." [Wikipedia:Epiblast, ZFIN:curator] +xref: BTO:0004593 +xref: FMA:296704 +xref: MAT:0000067 +xref: MIAA:0000067 +xref: VHOG:0000243 +xref: Wikipedia:Epiblast is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000051 CL:0000352 ! has part epiblast cell +[Term] +id: UBERON:0002533 +name: post-anal tail bud +def: "The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node." [BTO:0001445] +xref: AAO:0011104 +xref: BTO:0001445 +xref: EFO:0002748 +xref: EHDAA2:0001976 +xref: EHDAA:1595 +xref: EMAPA:16580 +xref: MAT:0000070 +xref: MIAA:0000070 +xref: TAO:0000077 +xref: VHOG:0000201 +xref: XAO:0000107 +xref: ZFA:0000077 +is_a: UBERON:0002050 ! embryonic structure +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata + [Term] id: UBERON:0002536 name: arthropod sensillum +def: "Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt]." [FBbt:00007152, Wikipedia:Sensillum] +xref: BTO:0001237 +xref: EFO:0000939 +xref: HAO:0000933 +xref: MAT:0000163 +xref: MIAA:0000163 +xref: TGMA:0000540 +xref: Wikipedia:Sensillum is_a: UBERON:0000020 ! sense organ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system relationship: RO:0002160 NCBITaxon:6656 ! Arthropoda @@ -35932,6 +52626,24 @@ relationship: RO:0002160 NCBITaxon:6656 ! Arthropoda [Term] id: UBERON:0002539 name: pharyngeal arch +def: "One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches." [http://orcid.org/0000-0002-6601-2165, PMID:16313389, ZFA:yb] +xref: AAO:0010359 +xref: BTO:0001785 +xref: EFO:0000959 +xref: EHDAA:571 +xref: EMAPA:16117 +xref: FMA:293015 +xref: GAID:1292 +xref: MAT:0000242 +xref: MESH:D001934 +xref: MIAA:0000242 +xref: NCIT:C34249 +xref: SCTID:308766004 +xref: TAO:0001306 +xref: VHOG:0000155 +xref: Wikipedia:Pharyngeal_arch +xref: XAO:0000096 +xref: ZFA:0001306 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0010188 ! protuberance is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -35943,6 +52655,12 @@ relationship: RO:0002256 UBERON:0007690 ! early pharyngeal endoderm [Term] id: UBERON:0002546 name: cranial placode +def: "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic." [http://www.ncbi.nlm.nih.gov/books/NBK53175/, https://github.com/obophenotype/uberon/issues/135, https://github.com/seger/aao/issues/4, https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/p/obo/xenopus-anatomy-xao-term-requests/11/] +xref: AAO:0010466 +xref: EFO:0001650 +xref: MAT:0000369 +xref: MIAA:0000369 +xref: XAO:0000305 is_a: UBERON:0005085 ! ectodermal placode relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -35950,12 +52668,43 @@ relationship: RO:0002160 NCBITaxon:7711 ! Chordata [Term] id: UBERON:0002553 name: anatomical cavity +def: "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina." [FMA:67552] +xref: BIRNLEX:1011 +xref: FMA:67552 +xref: galen:Cavity +xref: MA:0002447 +xref: NCIT:C34007 is_a: UBERON:0000464 ! anatomical space relationship: RO:0001015 UBERON:0000463 ! organism substance +[Term] +id: UBERON:0002558 +name: organ cavity +xref: BIRNLEX:1019 +xref: FMA:12237 +xref: SCTID:362606005 +is_a: UBERON:0002553 ! anatomical cavity + +[Term] +id: UBERON:0002561 +name: lumen of central nervous system +def: "The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube." [https://orcid.org/0000-0002-6601-2165] +xref: BIRNLEX:1029 +xref: FMA:75007 +is_a: UBERON:0002558 ! organ cavity +intersection_of: UBERON:0002558 ! organ cavity +intersection_of: RO:0002572 UBERON:0001017 ! central nervous system +relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system +relationship: RO:0002572 UBERON:0001017 ! central nervous system + [Term] id: UBERON:0002616 name: regional part of brain +def: "Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia." [BIRNLEX:1167] +xref: BIRNLEX:1167 +xref: FMA:55676 +xref: NCIT:C13031 +xref: SCTID:384763002 is_a: UBERON:0000073 ! regional part of nervous system is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000481 ! multi-tissue structure @@ -35966,16 +52715,36 @@ relationship: RO:0002473 UBERON:0003714 ! neural tissue [Term] id: UBERON:0002726 name: cervical spinal cord +def: "A spinal cord segment that adjacent_to a cervical region." [OBOL:automatic] +xref: BIRNLEX:1499 +xref: FMA:71166 +xref: MA:0003081 +xref: NCIT:C12892 +xref: neuronames:1654 +xref: SCTID:180960003 is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: RO:0002220 UBERON:0005434 ! adjacent to cervical region relationship: RO:0002160 NCBITaxon:8287 ! Sarcopterygii relationship: RO:0002220 UBERON:0005434 ! adjacent to cervical region -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0002925 name: trigeminal nucleus +def: "A nucleus of brain that is part of a trigeminal nuclear complex." [OBOL:automatic] +xref: BM:V +xref: BTO:0001074 +xref: CALOHA:TS-2077 +xref: EMAPA:35883 +xref: EV:0100271 +xref: FMA:71247 +xref: GAID:604 +xref: http://uri.neuinfo.org/nif/nifstd/nifext_11 +xref: MA:0001028 +xref: MESH:D014278 +xref: NCIT:C12807 +xref: SCTID:280164007 +xref: VHOG:0001353 is_a: UBERON:0000126 ! cranial nerve nucleus intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0007641 ! part of trigeminal nuclear complex @@ -35985,6 +52754,14 @@ relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve [Term] id: UBERON:0003023 name: pontine tegmentum +def: "Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133)." [BIRNLEX:923] +xref: BAMS:PTg +xref: BIRNLEX:923 +xref: DHBA:12416 +xref: FMA:71108 +xref: HBA:9135 +xref: SCTID:362401009 +xref: Wikipedia:Pontine_tegmentum is_a: UBERON:0000064 ! organ part is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0000988 ! part of pons @@ -35992,26 +52769,49 @@ relationship: BFO:0000051 UBERON:0002047 ! has part pontine raphe nucleus relationship: BFO:0000051 UBERON:0002128 ! has part superior olivary complex relationship: BFO:0000051 UBERON:0002148 ! has part locus ceruleus relationship: BFO:0000051 UBERON:0002149 ! has part superior salivatory nucleus -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003037 name: septum +def: "A wall, dividing a cavity or structure into smaller ones[WP]." [Wikipedia:Septum] +comment: general anatomical term in FMA +xref: AAO:0011127 +xref: FMA:86461 +xref: Wikipedia:Septum is_a: UBERON:0000061 ! anatomical structure relationship: RO:0001025 UBERON:0002553 ! anatomical cavity [Term] id: UBERON:0003038 name: thoracic spinal cord +def: "The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]." [Wikipedia:Thoracic_spinal_cord] +xref: BIRNLEX:966 +xref: FMA:71167 +xref: MA:0003082 +xref: NCIT:C12894 +xref: neuronames:1718 +xref: SCTID:278750009 +xref: Wikipedia:Thoracic_spinal_cord is_a: UBERON:0005844 ! spinal cord segment intersection_of: UBERON:0005844 ! spinal cord segment intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of trunk -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003052 name: midbrain-hindbrain boundary +def: "The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate." [GO:0021555] +xref: AAO:0011064 +xref: DMBA:16810 +xref: EHDAA2:0004395 +xref: EHDAA:5789 +xref: EMAPA:32857 +xref: NCIT:C93172 +xref: neuronames:2076 +xref: TAO:0000042 +xref: VHOG:0000649 +xref: XAO:0000016 +xref: ZFA:0000042 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction @@ -36025,6 +52825,15 @@ relationship: RO:0002495 UBERON:0009615 ! midbrain hindbrain boundary neural pla [Term] id: UBERON:0003055 name: periderm +def: "The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm." [ISBN:9780878932504, PMID:25133425, PMID:35582825] +xref: EHDAA2:0001846 +xref: EHDAA:6538 +xref: FMA:295662 +xref: NCIT:C34247 +xref: TAO:0001185 +xref: VHOG:0001680 +xref: XAO:0000029 +xref: ZFA:0001185 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0007376 ! outer epithelium is_a: UBERON:3000961 ! external integument structure @@ -36032,6 +52841,12 @@ is_a: UBERON:3000961 ! external integument structure [Term] id: UBERON:0003056 name: pre-chordal neural plate +def: "The portion of neural plate anterior to the mid-hindbrain junction." [XB:curator] +xref: AAO:0011084 +xref: TAO:0007016 +xref: VHOG:0001200 +xref: XAO:0000045 +xref: ZFA:0007016 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0003075 ! part of neural plate @@ -36040,6 +52855,11 @@ relationship: BSPO:0000096 UBERON:0009615 ! midbrain hindbrain boundary neural p [Term] id: UBERON:0003057 name: chordal neural plate +def: "The portion of neural plate posterior to the mid-hindbrain junction." [XB:curator] +xref: TAO:0007017 +xref: VHOG:0001201 +xref: XAO:0000046 +xref: ZFA:0007017 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003075 ! part of neural plate relationship: BSPO:0000099 UBERON:0009615 ! midbrain hindbrain boundary neural plate @@ -36047,6 +52867,15 @@ relationship: BSPO:0000099 UBERON:0009615 ! midbrain hindbrain boundary neural p [Term] id: UBERON:0003059 name: presomitic mesoderm +def: "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form." [ZFIN:curator] +xref: AAO:0011086 +xref: EFO:0001982 +xref: EMAPA:16189 +xref: EMAPA:16752 +xref: TAO:0000279 +xref: VHOG:0000559 +xref: XAO:0000057 +xref: ZFA:0000279 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: RO:0002387 UBERON:0002329 ! somite @@ -36058,6 +52887,17 @@ relationship: RO:0002495 UBERON:0007282 ! presumptive segmental plate [Term] id: UBERON:0003061 name: blood island +def: "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]." [Wikipedia:Blood_island_of_umbilical_vesicle] +xref: AAO:0011006 +xref: EFO:0003489 +xref: EHDAA:207 +xref: NCIT:C34113 +xref: TAO:0000094 +xref: TE:E5.11.2.0.0.0.4 +xref: VHOG:0000085 +xref: Wikipedia:Blood_island_of_umbilical_vesicle +xref: XAO:0000067 +xref: ZFA:0000094 is_a: UBERON:0006598 ! presumptive structure relationship: RO:0002202 UBERON:0003081 ! lateral plate mesoderm relationship: RO:0002387 UBERON:0002390 ! hematopoietic system @@ -36065,6 +52905,16 @@ relationship: RO:0002387 UBERON:0002390 ! hematopoietic system [Term] id: UBERON:0003063 name: prechordal plate +def: "A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue." [ISBN:0838580343, MP:0004387] +xref: AAO:0011085 +xref: EHDAA2:0001493 +xref: EHDAA:181 +xref: FMA:295532 +xref: TAO:0000060 +xref: VHOG:0000086 +xref: Wikipedia:Prechordal_plate +xref: XAO:0000079 +xref: ZFA:0000060 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003068 ! part of axial mesoderm relationship: RO:0002494 UBERON:0034878 ! prechordal mesoderm @@ -36072,6 +52922,18 @@ relationship: RO:0002494 UBERON:0034878 ! prechordal mesoderm [Term] id: UBERON:0003064 name: intermediate mesoderm +def: "The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:curators, Wikipedia:Intermediate_mesoderm] +xref: AAO:0010575 +xref: EMAPA:16056 +xref: EMAPA:16178 +xref: FMA:293147 +xref: NCIT:C34193 +xref: SCTID:361476001 +xref: TAO:0001206 +xref: VHOG:0000087 +xref: Wikipedia:Intermediate_mesoderm +xref: XAO:0000085 +xref: ZFA:0001206 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm relationship: BFO:0000050 UBERON:0005256 ! part of trunk mesenchyme @@ -36082,12 +52944,26 @@ relationship: RO:0002220 UBERON:0003081 ! adjacent to lateral plate mesoderm [Term] id: UBERON:0003067 name: dorsolateral placode +def: "Lateral neurogenic placodes positioned dorsal of the epibranchial placodes." [ZFIN:curator] +comment: The only remaining dorsolateral placode in land vertebrates is the otic/octaval placode +xref: TAO:0001310 +xref: VHOG:0000103 +xref: XAO:0000187 +xref: ZFA:0001310 is_a: UBERON:0009955 ! neurogenic placode relationship: BSPO:0000098 UBERON:0003078 ! epibranchial placode [Term] id: UBERON:0003068 name: axial mesoderm +def: "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GO:0048318, Wikipedia:Chordamesoderm] +xref: AAO:0011017 +xref: EFO:0003647 +xref: TAO:0001204 +xref: VHOG:0000107 +xref: Wikipedia:Chordamesoderm +xref: XAO:0000205 +xref: ZFA:0001204 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000926 ! part of mesoderm relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -36096,12 +52972,27 @@ relationship: RO:0002202 UBERON:0000926 ! mesoderm [Term] id: UBERON:0003070 name: trigeminal placode complex +def: "A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/693, PMID:22512454] +xref: EFO:0003433 +xref: EHDAA2:0004209 +xref: TAO:0000162 +xref: VHOG:0000109 +xref: XAO:0000225 +xref: ZFA:0000162 is_a: UBERON:0003067 ! dorsolateral placode relationship: RO:0002385 UBERON:0003942 ! somatosensory system [Term] id: UBERON:0003071 name: eye primordium +def: "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles." [GO:0046619, ZFA:0000570] +xref: AAO:0011038 +xref: EFO:0003541 +xref: EHDAA2:0004431 +xref: TAO:0000570 +xref: XAO:0000227 +xref: XAO:0004090 +xref: ZFA:0000570 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0001048 ! primordium is_a: UBERON:0005291 ! embryonic tissue @@ -36116,6 +53007,16 @@ relationship: RO:0002387 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0003072 name: optic cup +def: "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]." [MP:0004269, Wikipedia:Optic_cup_(embryology), ZFA:0001202] +xref: BTO:0005351 +xref: EHDAA2:0001303 +xref: EHDAA:2912 +xref: EMAPA:16674 +xref: NCIT:C34233 +xref: SCTID:308789007 +xref: TAO:0001202 +xref: VHOG:0000167 +xref: ZFA:0001202 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0010312 ! part of immature eye @@ -36125,6 +53026,19 @@ relationship: RO:0002256 UBERON:0003073 ! lens placode [Term] id: UBERON:0003073 name: lens placode +def: "A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]." [Wikipedia:Lens_placode, ZFIN:curator] +xref: AAO:0011055 +xref: EFO:0003494 +xref: EHDAA2:0000982 +xref: EHDAA:2908 +xref: EMAPA:16672 +xref: FMA:296767 +xref: NCIT:C34202 +xref: TAO:0000122 +xref: VHOG:0000166 +xref: Wikipedia:Lens_placode +xref: XAO:0000240 +xref: ZFA:0000122 is_a: UBERON:0002546 ! cranial placode is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0010312 ! immature eye @@ -36138,6 +53052,23 @@ relationship: RO:0002387 UBERON:0000965 ! lens of camera-type eye [Term] id: UBERON:0003075 name: neural plate +def: "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]." [ISBN:0815318960, OMD:neural+plate, Wikipedia:Neural_plate, ZFIN:curator] +xref: AAO:0011072 +xref: BTO:0001765 +xref: DHBA:10153 +xref: DMBA:15565 +xref: EHDAA:346 +xref: EHDAA:902 +xref: EMAPA:35593 +xref: FMA:293879 +xref: NCIT:C34225 +xref: neuronames:1362 +xref: RETIRED_EHDAA2:0001252 +xref: TAO:0000132 +xref: VHOG:0000068 +xref: Wikipedia:Neural_plate +xref: XAO:0000249 +xref: ZFA:0000132 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0016879 ! future central nervous system @@ -36148,6 +53079,11 @@ relationship: RO:0002495 UBERON:0007284 ! presumptive neural plate [Term] id: UBERON:0003076 name: posterior neural tube +xref: AAO:0011082 +xref: TAO:0007037 +xref: VHOG:0001383 +xref: XAO:0000250 +xref: ZFA:0007037 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: RO:0002202 UBERON:0003057 ! chordal neural plate @@ -36155,6 +53091,19 @@ relationship: RO:0002202 UBERON:0003057 ! chordal neural plate [Term] id: UBERON:0003077 name: paraxial mesoderm +def: "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]." [GO:0048339, https://github.com/obophenotype/uberon/issues/30] +xref: AAO:0010568 +xref: EFO:0003515 +xref: EMAPA:16183 +xref: EMAPA:16751 +xref: FMA:293145 +xref: NCIT:C34244 +xref: SCTID:361475002 +xref: TAO:0000255 +xref: VHOG:0000114 +xref: Wikipedia:Paraxial_mesoderm +xref: XAO:0000259 +xref: ZFA:0000255 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0015212 ! lateral structure @@ -36165,6 +53114,14 @@ relationship: RO:0002495 UBERON:0007285 ! presumptive paraxial mesoderm [Term] id: UBERON:0003078 name: epibranchial placode +def: "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia." [VHOG:0000117] +xref: AAO:0011036 +xref: EFO:0003455 +xref: FMA:293968 +xref: TAO:0001294 +xref: VHOG:0000117 +xref: XAO:0000284 +xref: ZFA:0001294 is_a: UBERON:0009955 ! neurogenic placode relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system relationship: RO:0002202 UBERON:0000076 ! external ectoderm @@ -36173,6 +53130,11 @@ relationship: RO:0002385 UBERON:0002410 ! autonomic nervous system [Term] id: UBERON:0003080 name: anterior neural tube +xref: AAO:0011012 +xref: TAO:0007038 +xref: VHOG:0001384 +xref: XAO:0000307 +xref: ZFA:0007038 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: RO:0002202 UBERON:0003056 ! pre-chordal neural plate @@ -36180,6 +53142,19 @@ relationship: RO:0002202 UBERON:0003056 ! pre-chordal neural plate [Term] id: UBERON:0003081 name: lateral plate mesoderm +def: "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]." [MP:0010117, Wikipedia:Lateral_plate_mesoderm] +xref: AAO:0010574 +xref: EHDAA2:0000919 +xref: EHDAA:379 +xref: EMAPA:16179 +xref: FMA:293149 +xref: NCIT:C34199 +xref: SCTID:361477005 +xref: TAO:0000121 +xref: VHOG:0000118 +xref: Wikipedia:Lateral_plate_mesoderm +xref: XAO:0000311 +xref: ZFA:0000121 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -36191,6 +53166,24 @@ relationship: RO:0002221 UBERON:0003887 ! intraembryonic coelom [Term] id: UBERON:0003082 name: myotome +def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells." [AEO:0001018] +xref: AAO:0011067 +xref: AEO:0001018 +xref: BTO:0000742 +xref: EHDAA2_RETIRED:0003431 +xref: EHDAA:1721 +xref: EHDAA:1727 +xref: EHDAA:1733 +xref: EHDAA:1739 +xref: EMAPA:32841 +xref: FMA:295658 +xref: NCIT:C34214 +xref: SCTID:344535001 +xref: TAO:0001056 +xref: VHOG:0001244 +xref: Wikipedia:Myotome +xref: XAO:0000315 +xref: ZFA:0001056 is_a: UBERON:0017650 ! developing mesenchymal structure relationship: RO:0002202 UBERON:0004290 ! dermomyotome relationship: RO:0002433 UBERON:0001630 ! muscle organ @@ -36198,6 +53191,15 @@ relationship: RO:0002433 UBERON:0001630 ! muscle organ [Term] id: UBERON:0003083 name: trunk neural crest +def: "Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]." [ISBN:0815318960, Wikipedia:Trunk_neural_crest] +xref: AAO:0010582 +xref: EFO:0003605 +xref: EHDAA2:0001901 +xref: TAO:0001024 +xref: VHOG:0000062 +xref: Wikipedia:Trunk_neural_crest +xref: XAO:0000319 +xref: ZFA:0001024 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -36207,15 +53209,53 @@ relationship: BFO:0000051 CL:0000011 ! has part migratory trunk neural crest cel [Term] id: UBERON:0003084 name: heart primordium +def: "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone." [ZFIN:curator] +xref: AAO:0011044 +xref: BTO:0001887 +xref: NCIT:C34276 +xref: TAO:0000028 +xref: XAO:0000336 +xref: ZFA:0000028 is_a: UBERON:0001048 ! primordium relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system relationship: RO:0002202 UBERON:0003081 ! lateral plate mesoderm relationship: RO:0002202 UBERON:0004140 ! primary heart field relationship: RO:0002202 UBERON:0007005 ! cardiogenic splanchnic mesoderm +[Term] +id: UBERON:0003086 +name: caudal artery +def: "Extension of the dorsal aorta in the tail." [Wikipedia:Caudal_artery, ZFIN:curator] +xref: AAO:0011023 +xref: EFO:0003472 +xref: TAO:0000011 +xref: VHOG:0000123 +xref: Wikipedia:Caudal_artery +xref: XAO:0000364 +xref: ZFA:0000011 +is_a: UBERON:0001637 ! artery +is_a: UBERON:0003524 ! tail blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +intersection_of: RO:0002252 UBERON:0005805 ! dorsal aorta +relationship: BFO:0000050 UBERON:2001073 ! part of axial vasculature +relationship: RO:0002252 UBERON:0005805 ! dorsal aorta + [Term] id: UBERON:0003089 name: sclerotome +def: "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]." [https://github.com/obophenotype/uberon/issues/316, Wikipedia:Sclerotome, XB:curator] +xref: AAO:0010571 +xref: AEO:0000212 +xref: EHDAA2:0003439 +xref: EMAPA:31159 +xref: FMA:295652 +xref: NCIT:C34287 +xref: TAO:0001080 +xref: VHOG:0000680 +xref: Wikipedia:Sclerotome +xref: XAO:0000397 +xref: ZFA:0001080 is_a: UBERON:0005856 ! developing mesenchymal condensation is_a: UBERON:0007530 ! migrating mesenchyme population relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -36224,6 +53264,16 @@ relationship: RO:0002202 UBERON:0002329 ! somite [Term] id: UBERON:0003099 name: cranial neural crest +def: "Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage." [MGI:anna] +xref: AAO:0010580 +xref: EFO:0003645 +xref: EHDAA2:0004420 +xref: EMAPA:16091 +xref: TAO:0001194 +xref: VHOG:0000063 +xref: Wikipedia:Cranial_neural_crest +xref: XAO:0001001 +xref: ZFA:0001194 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -36233,22 +53283,69 @@ relationship: BFO:0000051 CL:0000008 ! has part migratory cranial neural crest c [Term] id: UBERON:0003100 name: female organism +def: "Gonochoristic organism that can produce female gametes." [CARO:0000028] +xref: AAO:0010030 +xref: BILA:0000028 +xref: CARO:0000028 +xref: FMA:67812 +xref: HAO:0000028 +xref: SCTID:362608006 +xref: TAO:0000303 +xref: TGMA:0001839 +xref: XAO:0003005 +xref: ZFA:0000303 is_a: UBERON:0000468 ! multicellular organism [Term] id: UBERON:0003102 name: surface structure +def: "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/24] +xref: AAO:0010337 +xref: AEO_RETIRED:0000010 +xref: EHDAA2_RETIRED:0003010 +xref: galen:SurfaceRegion +xref: TAO:0000292 +xref: VSAO:0000001 +xref: Wikipedia:Surface_structure +xref: XAO:0003028 +xref: ZFA:0000292 is_a: UBERON:0000061 ! anatomical structure relationship: RO:0002220 UBERON:0013514 ! adjacent to space surrounding organism [Term] id: UBERON:0003103 name: compound organ +def: "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types." [CARO:0000024] +xref: AAO:0010015 +xref: AEO:0000024 +xref: BILA:0000024 +xref: CARO:0000024 +xref: EHDAA2:0003024 +xref: HAO:0000024 +xref: TADS:0000598 +xref: TAO:0000496 +xref: TGMA:0001837 +xref: VHOG:0001723 +xref: XAO:0003041 +xref: ZFA:0000496 is_a: UBERON:0000062 ! organ [Term] id: UBERON:0003104 name: mesenchyme +def: "Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme." [https://archive.org/details/invertebratesnde00brus/page/n240/mode/2up, https://en.wikipedia.org/wiki/Mesenchyme, https://github.com/obophenotype/uberon/issues/1641] +xref: AAO:0010427 +xref: AEO:0000145 +xref: BTO:0001393 +xref: CALOHA:TS-0620 +xref: EHDAA2:0003145 +xref: EV:0100007 +xref: NCIT:C13301 +xref: TAO:0000393 +xref: VHOG:0000170 +xref: Wikipedia:Mesenchyme +xref: XAO:0003046 +xref: ZFA:0000393 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002473 CL:0008019 ! mesenchymal cell @@ -36257,9 +53354,30 @@ relationship: RO:0002254 UBERON:0000926 {gci_filler="NCBITaxon:7711", gci_relati relationship: RO:0002328 GO:0032502 ! developmental process relationship: RO:0002473 CL:0008019 ! mesenchymal cell +[Term] +id: UBERON:0003112 +name: olfactory region +def: "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ." [TAO:0000351] +xref: AAO:0010206 +xref: EFO:0003525 +xref: NCIT:C98765 +xref: TAO:0000351 +xref: XAO:0003172 +xref: ZFA:0000351 +is_a: UBERON:0034921 ! multi organ part structure +relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium +relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium + [Term] id: UBERON:0003113 name: dermatocranium +def: "Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]." [Wikipedia:Skull_roof, ZFA:0000863] +xref: AAO:0010154 +xref: TAO:0000863 +xref: VHOG:0001665 +xref: Wikipedia:Skull_roof +xref: XAO:0003169 +xref: ZFA:0000863 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system relationship: BFO:0000050 UBERON:0010364 ! part of dermal skeleton relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -36267,16 +53385,47 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0003115 name: pharyngeal arch 4 +def: "Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus." [MP:0006340] +xref: AAO:0010366 +xref: EHDAA2:0000086 +xref: EHDAA:1663 +xref: EMAPA:16760 +xref: FMA:293035 +xref: SCTID:308770007 +xref: TAO:0001599 +xref: VHOG:0000299 +xref: XAO:0000449 +xref: ZFA:0001607 is_a: UBERON:0002539 ! pharyngeal arch [Term] id: UBERON:0003117 name: pharyngeal arch 6 +def: "The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles." [MP:0006347] +xref: AAO:0010368 +xref: EHDAA2:0004075 +xref: EMAPA:32766 +xref: FMA:293047 +xref: SCTID:308772004 +xref: TAO:0001601 +xref: VHOG:0001205 +xref: XAO:0000453 +xref: ZFA:0001609 is_a: UBERON:0002539 ! pharyngeal arch [Term] id: UBERON:0003118 name: pharyngeal arch artery 1 +def: "The vessels formed within the first pair of branchial arches in embryogenesis." [MP:0010355] +xref: AAO:0010415 +xref: EHDAA2:0000007 +xref: EMAPA:16202 +xref: EMAPA:16685 +xref: SCTID:308774003 +xref: TAO:0005005 +xref: VHOG:0000149 +xref: XAO:0000342 +xref: ZFA:0005005 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 @@ -36286,6 +53435,16 @@ relationship: RO:0002433 UBERON:0004362 ! pharyngeal arch 1 [Term] id: UBERON:0003121 name: pharyngeal arch artery 4 +def: "The vessels formed within the fourth pair of branchial arches in embryogenesis." [MP:0006354] +comment: proximal right subclavian +xref: AAO:0010420 +xref: EHDAA2:0000087 +xref: EMAPA:17004 +xref: SCTID:308777005 +xref: TAO:0005008 +xref: Wikipedia:Aortic_arches#Arch_4 +xref: XAO:0000355 +xref: ZFA:0005008 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 @@ -36294,6 +53453,16 @@ relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 [Term] id: UBERON:0003123 name: pharyngeal arch artery 6 +def: "The vessels formed within the sixth pair of branchial arches in embryogenesis." [MP:0006355] +xref: AAO:0010422 +xref: EHDAA2:0000102 +xref: EMAPA:17005 +xref: SCTID:308779008 +xref: TAO:0005016 +xref: VHOG:0000144 +xref: Wikipedia:Aortic_arches#Arch_6 +xref: XAO:0000353 +xref: ZFA:0005016 is_a: UBERON:0004363 ! pharyngeal arch artery intersection_of: UBERON:0004363 ! pharyngeal arch artery intersection_of: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 @@ -36302,23 +53471,65 @@ relationship: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 [Term] id: UBERON:0003126 name: trachea +def: "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]." [GO:0060438, Wikipedia:Vertebrate_trachea] +xref: AAO:0010140 +xref: BTO:0001388 +xref: CALOHA:TS-1060 +xref: EFO:0000935 +xref: EHDAA2:0002066 +xref: EHDAA:3078 +xref: EMAPA:16853 +xref: EV:0100040 +xref: FMA:7394 +xref: GAID:361 +xref: MA:0000441 +xref: MAT:0000137 +xref: MESH:D014132 +xref: MIAA:0000137 +xref: NCIT:C12428 +xref: SCTID:181213009 +xref: VHOG:0000371 +xref: Wikipedia:Vertebrate_trachea +xref: XAO:0000118 is_a: UBERON:0000117 ! respiratory tube relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree relationship: RO:0001025 UBERON:0002224 ! thoracic cavity relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002202 UBERON:0008947 ! respiratory primordium relationship: RO:0002433 UBERON:0001004 ! respiratory system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003128 name: cranium +def: "Upper portion of the skull that excludes the mandible (when present in the organism)." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Cranium_(anatomy)] +xref: BTO:0001328 +xref: EFO:0000831 +xref: EHDAA:6029 +xref: FMA:71325 +xref: MA:0000316 +xref: MAT:0000340 +xref: MIAA:0000340 +xref: SCTID:181889008 +xref: VHOG:0000334 +xref: Wikipedia:Cranium_(anatomy) is_a: UBERON:0000075 ! subdivision of skeletal system -property_value: RO:0002175 NCBITaxon:7762 [Term] id: UBERON:0003129 name: skull +def: "Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]." [http://sourceforge.net/tracker/?func=detail&aid=2962656&group_id=76834&atid=1205376, PMID:11523816, Wikipedia:Skull] +xref: BTO:0001295 +xref: CALOHA:TS-2344 +xref: EHDAA2:0000325 +xref: EMAPA:17680 +xref: FMA:46565 +xref: GAID:82 +xref: galen:Skull +xref: MESH:D012886 +xref: NCIT:C12789 +xref: SCTID:110530005 +xref: Wikipedia:Skull +xref: WikipediaCategory:Skull is_a: UBERON:0000075 ! subdivision of skeletal system is_a: UBERON:0010314 ! structure with developmental contribution from neural crest relationship: BFO:0000050 UBERON:0000033 ! part of head @@ -36330,6 +53541,13 @@ relationship: RO:0002160 NCBITaxon:89593 ! Craniata [Term] id: UBERON:0003133 name: reproductive organ +def: "An organ involved in reproduction." [UBERON:xp] +xref: MA:0001752 +xref: MESH:D005835 +xref: NCIT:C25177 +xref: SCTID:128181006 +xref: TGMA:0000591 +xref: WBbt:0008422 is_a: UBERON:0000062 ! organ is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000062 ! organ @@ -36339,6 +53557,9 @@ relationship: RO:0002216 GO:0022414 ! capable of part of reproductive process [Term] id: UBERON:0003134 name: female reproductive organ +def: "A female organ involved in reproduction." [UBERON:xp] +xref: EMAPA:28540 +xref: MA:0000544 is_a: UBERON:0003133 ! reproductive organ intersection_of: UBERON:0003133 ! reproductive organ intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism @@ -36347,19 +53568,42 @@ relationship: BFO:0000050 UBERON:0000474 ! part of female reproductive system [Term] id: UBERON:0003215 name: alveolus +def: "Organ part that has the form of a hollow cavity[WP]." [Wikipedia:Alveolus] +xref: EFO:0002513 +xref: FMA:82493 +xref: NCIT:C12986 +xref: Wikipedia:Alveolus is_a: UBERON:0000064 ! organ part [Term] id: UBERON:0003218 name: ovary septum +def: "Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]." [GO:0080126] is_a: UBERON:0003037 ! septum intersection_of: UBERON:0003037 ! septum intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary +[Term] +id: UBERON:0003235 +name: epithelium of upper jaw +def: "An epithelium that is part of a upper jaw [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0002119 +xref: EHDAA:8027 +xref: EMAPA:18971 +is_a: UBERON:0035037 ! jaw epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region + [Term] id: UBERON:0003236 name: epithelium of lower jaw +def: "An epithelium that is part of a lower jaw [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001019 +xref: EHDAA:7999 +xref: EMAPA:35516 +xref: VHOG:0000802 is_a: UBERON:0035037 ! jaw epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region @@ -36368,6 +53612,11 @@ relationship: BFO:0000050 UBERON:0001710 ! part of lower jaw region [Term] id: UBERON:0003257 name: yolk sac endoderm +def: "The portion of the yolk sac that is derived from endoderm and lines the yolk sac." [UBERON:cjm] +xref: EHDAA2:0002215 +xref: EHDAA:166 +xref: EMAPA:16086 +xref: VHOG:0000626 is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0005911 ! endo-epithelium @@ -36379,6 +53628,9 @@ relationship: RO:0002007 UBERON:0001040 ! bounding layer of yolk sac [Term] id: UBERON:0003258 name: endoderm of foregut +def: "An endoderm that is part of a foregut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0004568 +xref: EHDAA:524 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0015833 ! foregut epithelium @@ -36386,18 +53638,81 @@ intersection_of: UBERON:0000490 ! unilaminar epithelium intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut intersection_of: RO:0002202 UBERON:0000925 ! endoderm +[Term] +id: UBERON:0003259 +name: endoderm of midgut +def: "An endoderm that is part of a midgut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA:987 +xref: EMAPA:16257 +xref: RETIRED_EHDAA2:0001194 +xref: VHOG:0001080 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0003352 ! epithelium of midgut +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000490 ! unilaminar epithelium +intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut +intersection_of: RO:0002202 UBERON:0000925 ! endoderm + +[Term] +id: UBERON:0003260 +name: endoderm of hindgut +def: "An endoderm that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA:979 +xref: RETIRED_EHDAA2:0000781 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0003353 ! epithelium of hindgut +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000490 ! unilaminar epithelium +intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut +intersection_of: RO:0002202 UBERON:0000925 ! endoderm + [Term] id: UBERON:0003269 name: skeletal muscle tissue of eye +def: "A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000486 +xref: EHDAA:2923 +xref: EMAPA:17844 is_a: UBERON:0001134 ! skeletal muscle tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye +[Term] +id: UBERON:0003277 +name: skeleton of upper jaw +def: "A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000622 +xref: EHDAA2:0002128 +xref: EHDAA:8041 +xref: EMAPA:17927 +xref: FMA:54397 +xref: MA:0001908 +xref: VHOG:0000429 +xref: XAO:0003087 +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010912 ! subdivision of skeleton +intersection_of: UBERON:0010912 ! subdivision of skeleton +intersection_of: RO:0002576 UBERON:0001709 ! upper jaw region +relationship: BFO:0000050 UBERON:0001708 ! part of jaw skeleton +relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: RO:0002576 UBERON:0001709 ! upper jaw region + [Term] id: UBERON:0003278 name: skeleton of lower jaw +def: "A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000274 +xref: EHDAA2:0004606 +xref: EHDAA:8005 +xref: EMAPA:17910 +xref: FMA:54398 +xref: MA:0001906 +xref: TAO:0001273 +xref: VHOG:0000428 +xref: XAO:0003084 +xref: ZFA:0001273 is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton @@ -36410,15 +53725,81 @@ relationship: RO:0002576 UBERON:0001710 ! lower jaw region [Term] id: UBERON:0003279 name: endothelium of trachea +def: "An endothelium that is part of a trachea." [OBOL:automatic] +xref: EHDAA:3082 +xref: RETIRED_EHDAA2:0002068 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001901 ! epithelium of trachea is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea +[Term] +id: UBERON:0003281 +name: mesentery of stomach +def: "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum." [http://medical-dictionary.thefreedictionary.com/mesogastrium] +xref: EHDAA2:0001922 +xref: EHDAA:2999 +xref: EMAPA:17024 +xref: MA:0001617 +xref: SCTID:261623000 +xref: VHOG:0000358 +is_a: UBERON:0004854 ! gastrointestinal system mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach +relationship: BFO:0000050 UBERON:0000945 ! part of stomach +relationship: RO:0002433 UBERON:0000945 ! stomach + +[Term] +id: UBERON:0003282 +name: mesentery of heart +def: "A mesentery that surrounds the heart." [MA:th] +xref: EHDAA:432 +xref: EMAPA:16212 +xref: RETIRED_EHDAA2:0000739 +xref: VHOG:0000353 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0000948 ! part of heart +relationship: BFO:0000050 UBERON:0000948 ! part of heart + +[Term] +id: UBERON:0003283 +name: mesentery of oesophagus +def: "A mesentery that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001288 +xref: EHDAA:2943 +xref: EMAPA:16836 +xref: MA:0001569 +xref: VHOG:0000415 +is_a: UBERON:0001975 ! serosa of esophagus +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus + +[Term] +id: UBERON:0003284 +name: mesentery of midgut +def: "A mesentery that is part of a midgut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001202 +xref: EHDAA:3031 +xref: EMAPA:16721 +xref: EMAPA:17039 +xref: EMAPA:17197 +xref: VHOG:0000413 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut +relationship: BFO:0000050 UBERON:0001045 ! part of midgut + [Term] id: UBERON:0003294 name: gland of foregut +def: "A gland that is part of a foregut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000567 +xref: EHDAA:950 +xref: EMAPA:16557 +xref: VHOG:0000650 is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut @@ -36427,6 +53808,11 @@ relationship: BFO:0000050 UBERON:0001041 ! part of foregut [Term] id: UBERON:0003295 name: pharyngeal gland +def: "Racemose mucous glands beneath the mucous membrane of the pharynx." [http://www.biology-online.org/dictionary/] +xref: BTO:0004849 +xref: EHDAA2:0001461 +xref: EHDAA:2967 +xref: FMA:55075 is_a: UBERON:0003408 ! gland of digestive tract is_a: UBERON:0036225 ! respiratory system gland intersection_of: UBERON:0002530 ! gland @@ -36436,6 +53822,11 @@ relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx [Term] id: UBERON:0003297 name: gland of integumental system +def: "A gland that is part of a integumental system [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000837 +xref: EMAPA:17758 +xref: MA:0000144 +xref: VHOG:0000654 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system @@ -36444,6 +53835,9 @@ relationship: BFO:0000050 UBERON:0002416 ! part of integumental system [Term] id: UBERON:0003304 name: mesoderm blood island +def: "A blood island that is part of a mesoderm." [OBOL:automatic] +xref: EHDAA2:0003241 +xref: EHDAA:170 is_a: UBERON:0003061 ! blood island is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007503 ! epithelial vesicle @@ -36456,6 +53850,11 @@ relationship: BFO:0000050 UBERON:0007798 ! part of vascular system [Term] id: UBERON:0003314 name: eye mesenchyme +def: "Mesenchyme that is part of a developing camera-type eye." [OBOL:automatic] +xref: EHDAA2:0000485 +xref: EHDAA:2910 +xref: EMAPA:16673 +xref: VHOG:0001084 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0009891 ! facial mesenchyme intersection_of: UBERON:0003104 ! mesenchyme @@ -36466,32 +53865,161 @@ relationship: RO:0002202 UBERON:0009920 ! optic neural crest [Term] id: UBERON:0003315 name: mesenchyme of ovary +def: "Mesenchyme that is part of a developing ovary [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001362 +xref: EHDAA:8128 +xref: VHOG:0001441 is_a: UBERON:0003855 ! gonad mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003316 name: mesenchyme of yolk sac +def: "The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme." [UBERON:cjm] +xref: EHDAA2:0002216 +xref: EHDAA:168 +xref: EHDAA:205 +xref: EMAPA:16087 +xref: EMAPA:16267 +xref: VHOG:0000503 +xref: VHOG:0000617 is_a: UBERON:0010333 ! extraembryonic membrane mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001040 ! part of yolk sac relationship: BFO:0000050 UBERON:0001040 ! part of yolk sac +[Term] +id: UBERON:0003323 +name: mesenchyme of upper jaw +def: "Mesenchyme that is part of a developing upper jaw [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0002124 +xref: EHDAA:8031 +xref: EMAPA:17929 +xref: VHOG:0001099 +is_a: UBERON:0009891 ! facial mesenchyme +is_a: UBERON:0034995 ! jaw mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: RO:0002202 UBERON:0009526 ! maxillary process mesenchyme + [Term] id: UBERON:0003324 name: mesenchyme of lower jaw +def: "Mesenchyme that is part of a developing lower jaw [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001024 +xref: EHDAA:8003 +xref: EMAPA:17916 +xref: VHOG:0001069 is_a: UBERON:0034995 ! jaw mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: BFO:0000050 UBERON:0001710 ! part of lower jaw region relationship: RO:0002202 UBERON:0006905 ! mandibular process mesenchyme +[Term] +id: UBERON:0003329 +name: submucosa of anal canal +def: "A submucosa that is part of an anal canal [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27217 +xref: EMAPA:27227 +xref: EMAPA:27535 +xref: FMA:85399 +xref: SCTID:7892006 +is_a: UBERON:0001208 ! submucosa of large intestine +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal + +[Term] +id: UBERON:0003330 +name: submucosa of rectum +def: "The submucous layer of the wall of the rectum." [BTO:0002114] +xref: BTO:0002114 +xref: EMAPA:27083 +xref: FMA:15034 +xref: SCTID:71683001 +is_a: UBERON:0001208 ! submucosa of large intestine +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + +[Term] +id: UBERON:0003331 +name: submucosa of colon +def: "A submucosa that is part of a colon [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27379 +xref: FMA:14985 +xref: MA:0003200 +xref: SCTID:61647009 +is_a: UBERON:0001208 ! submucosa of large intestine +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0003332 +name: submucosa of duodenum +def: "A submucosa that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27027 +xref: EMAPA:27097 +xref: EMAPA:27239 +xref: FMA:14943 +xref: MA:0003213 +xref: SCTID:76519004 +is_a: UBERON:0001205 ! submucosa of small intestine +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + +[Term] +id: UBERON:0003334 +name: serosa of rectum +def: "A serous membrane that is part of a rectum [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27087 +xref: FMA:15039 +is_a: UBERON:0001209 ! serosa of large intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + +[Term] +id: UBERON:0003335 +name: serosa of colon +def: "A serous membrane that is part of a colon [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27387 +xref: FMA:14990 +xref: MA:0003199 +xref: SCTID:90132000 +is_a: UBERON:0001209 ! serosa of large intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0003336 +name: serosa of duodenum +def: "A serous membrane that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27247 +xref: FMA:14948 +xref: MA:0003212 +xref: SCTID:1236009 +is_a: UBERON:0001206 ! serosa of small intestine +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + [Term] id: UBERON:0003338 name: ganglion of peripheral nervous system +def: "A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO)." [BIRNLEX:2548] +xref: BIRNLEX:2548 +xref: BTO:0001123 +xref: EMAPA:32814 +xref: MA:0001161 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system @@ -36500,23 +54028,60 @@ relationship: BFO:0000050 UBERON:0000010 ! part of peripheral nervous system [Term] id: UBERON:0003339 name: ganglion of central nervous system +def: "A ganglion that is part of a central nervous system [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000227 +xref: EMAPA:16658 +xref: FMA:83843 is_a: UBERON:0000045 ! ganglion is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system +[Term] +id: UBERON:0003342 +name: mucosa of anal canal +def: "A mucosa that is part of an anal canal [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27531 +xref: FMA:74654 +xref: NCIT:C60784 +xref: SCTID:362170004 +is_a: UBERON:0001207 ! mucosa of large intestine +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal + [Term] id: UBERON:0003343 name: mucosa of oral region +def: "A mucosa that is part of a oral opening [Automatically generated definition]." [OBOL:automatic] +xref: SCTID:362083000 is_a: UBERON:0003729 ! mouth mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000166 ! part of oral opening relationship: BFO:0000050 UBERON:0000166 ! part of oral opening +[Term] +id: UBERON:0003346 +name: mucosa of rectum +def: "A mucosa that is part of a rectum [Automatically generated definition]." [OBOL:automatic] +xref: CALOHA:TS-2107 +xref: EMAPA:27081 +xref: FMA:15033 +xref: MA:0003218 +xref: SCTID:362167003 +is_a: UBERON:0001207 ! mucosa of large intestine +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + [Term] id: UBERON:0003350 name: epithelium of mucosa +def: "A layer of epithelial cells on the surface of the mucosa." [BTO:0003752] +comment: lies on top of lamina propria +xref: BTO:0003752 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000344 ! part of mucosa @@ -36525,6 +54090,15 @@ relationship: BFO:0000050 UBERON:0000344 ! part of mucosa [Term] id: UBERON:0003351 name: pharyngeal epithelium +def: "An epithelium that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] +xref: BSA:0000112 +xref: BTO:0005240 +xref: EMAPA:16708 +xref: MA:0002725 +xref: RETIRED_EHDAA2:0001460 +xref: TAO:0001174 +xref: XAO:0003202 +xref: ZFA:0001174 is_a: UBERON:0003929 ! digestive tract epithelium is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0005911 ! endo-epithelium @@ -36533,9 +54107,53 @@ intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: RO:0002202 UBERON:0007690 ! early pharyngeal endoderm +[Term] +id: UBERON:0003352 +name: epithelium of midgut +def: "An epithelium that is part of a midgut." [OBOL:automatic] +xref: BTO:0005053 +xref: EHDAA2:0001195 +xref: EMAPA:16569 +xref: MA:0003205 +is_a: UBERON:0003929 ! digestive tract epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut +relationship: BFO:0000050 UBERON:0001045 ! part of midgut + +[Term] +id: UBERON:0003353 +name: epithelium of hindgut +def: "An epithelium that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000782 +xref: EMAPA:16717 +xref: MA:0003206 +is_a: UBERON:0003929 ! digestive tract epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut +relationship: BFO:0000050 UBERON:0001046 ! part of hindgut + +[Term] +id: UBERON:0003354 +name: epithelium of rectum +def: "An epithelium that is part of a rectum [Automatically generated definition]." [OBOL:automatic] +xref: CALOHA:TS-2066 +xref: EHDAA2:0001594 +xref: EMAPA:17898 +xref: FMA:17510 +xref: MA:0003219 +xref: VHOG:0001037 +is_a: UBERON:0001278 ! epithelium of large intestine +is_a: UBERON:0016885 ! epithelium of terminal part of digestive tract +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + [Term] id: UBERON:0003364 name: epithelium of right lung +def: "An epithelium that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:17663 +xref: MA:0003132 is_a: UBERON:0000115 ! lung epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -36544,6 +54162,9 @@ relationship: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0003365 name: epithelium of left lung +def: "An epithelium that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:17655 +xref: MA:0003131 is_a: UBERON:0000115 ! lung epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung @@ -36552,6 +54173,10 @@ relationship: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0003372 name: pectoral appendage bud ectoderm +def: "An unilaminar epithelium that surrounds a pectoral appendage bud." [OBOL:automatic] +xref: EHDAA2:0002134 +xref: EMAPA:16407 +xref: VHOG:0001047 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium @@ -36565,15 +54190,26 @@ relationship: RO:0002202 UBERON:0000076 ! external ectoderm [Term] id: UBERON:0003379 name: cardiac muscle of right atrium +def: "A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0004155 +xref: EMAPA:17326 +xref: FMA:7282 +xref: SCTID:362018002 +xref: VHOG:0001227 is_a: UBERON:0004490 ! cardiac muscle tissue of atrium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium relationship: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003380 name: cardiac muscle of left atrium +def: "A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0004154 +xref: EMAPA:17320 +xref: FMA:7285 +xref: SCTID:189936008 +xref: VHOG:0001225 is_a: UBERON:0004490 ! cardiac muscle tissue of atrium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium @@ -36582,6 +54218,10 @@ relationship: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium [Term] id: UBERON:0003381 name: cardiac muscle of right ventricle +def: "A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:17342 +xref: FMA:83452 +xref: VHOG:0001236 is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle @@ -36590,6 +54230,10 @@ relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle [Term] id: UBERON:0003382 name: cardiac muscle of left ventricle +def: "A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:17339 +xref: FMA:83453 +xref: VHOG:0001234 is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle @@ -36598,15 +54242,21 @@ relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle [Term] id: UBERON:0003383 name: cardiac muscle tissue of interventricular septum +def: "A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0004158 +xref: EMAPA:17335 +xref: FMA:84084 +xref: VHOG:0000999 is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum is_a: UBERON:0004667 ! interventricular septum muscular part intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003384 name: skeletal muscle tissue of pharynx +def: "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18963 is_a: UBERON:0004830 ! respiratory system skeletal muscle intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx @@ -36615,6 +54265,9 @@ relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx [Term] id: UBERON:0003386 name: smooth muscle of eye +def: "Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi." [MGI:cwg, MP:0005247] +xref: EMAPA:18807 +xref: MA:0001268 is_a: UBERON:0001135 ! smooth muscle tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -36625,16 +54278,23 @@ relationship: RO:0002433 UBERON:0001015 ! musculature [Term] id: UBERON:0003387 name: smooth muscle of trachea +def: "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001391 +xref: EMAPA:19192 +xref: FMA:262010 +xref: MA:0001863 +xref: NCIT:C49306 is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002433 UBERON:0003126 ! trachea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003388 name: mesothelium of pericardial cavity +def: "A mesothelium that is part of a pericardium [Automatically generated definition]." [OBOL:automatic] +xref: RETIRED_EHDAA2:0001436 is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: BFO:0000050 UBERON:0002407 ! part of pericardium @@ -36643,6 +54303,8 @@ relationship: BFO:0000050 UBERON:0002407 ! part of pericardium [Term] id: UBERON:0003389 name: mesothelium of diaphragm +def: "A mesothelium that is part of a diaphragm [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18429 is_a: UBERON:0001136 ! mesothelium is_a: UBERON:0004807 ! respiratory system epithelium intersection_of: UBERON:0001136 ! mesothelium @@ -36652,14 +54314,76 @@ relationship: BFO:0000050 UBERON:0001103 ! part of diaphragm [Term] id: UBERON:0003390 name: mesothelium of pleural cavity +def: "A mesothelium that is part of a pleural cavity [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0003155 +xref: EHDAA2:0001476 +xref: EMAPA:16775 +xref: FMA:18148 is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: RO:0001025 UBERON:0002402 ! pleural cavity relationship: RO:0001025 UBERON:0002402 ! pleural cavity +[Term] +id: UBERON:0003393 +name: mesentery of urinary system +def: "A mesentery that is part of a urinary system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:17367 +xref: MA:0003233 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001008 ! part of renal system +relationship: BFO:0000050 UBERON:0001008 ! part of renal system + +[Term] +id: UBERON:0003394 +name: mesentery of hindgut +def: "A mesentery that is part of a hindgut [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:16718 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut +relationship: BFO:0000050 UBERON:0001046 ! part of hindgut + +[Term] +id: UBERON:0003395 +name: mesentery of rectum +def: "A mesentery that is part of a rectum [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18664 +is_a: UBERON:0003334 ! serosa of rectum +is_a: UBERON:0004854 ! gastrointestinal system mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum + +[Term] +id: UBERON:0003396 +name: mesentery of colon +def: "A mesentery that is part of a colon [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18942 +xref: FMA:14645 +xref: SCTID:245457004 +is_a: UBERON:0003335 ! serosa of colon +is_a: UBERON:0004854 ! gastrointestinal system mesentery +is_a: UBERON:0007826 ! peritoneal mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0003397 +name: mesentery of duodenum +def: "A mesentery that is part of a duodenum [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:19081 +is_a: UBERON:0001170 ! mesentery of small intestine +is_a: UBERON:0003336 ! serosa of duodenum +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum + [Term] id: UBERON:0003406 name: cartilage of respiratory system +def: "A cartilage element that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18694 +xref: MA:0001818 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -36668,6 +54392,9 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003408 name: gland of digestive tract +def: "A gland that is part of a digestive tract [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18815 +xref: MA:0003202 is_a: UBERON:0002530 ! gland is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0002530 ! gland @@ -36677,6 +54404,12 @@ relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: UBERON:0003413 name: pectoral appendage bud mesenchyme +def: "Mesenchyme that is part of a pectoral appendage bud." [OBOL:automatic] +xref: EHDAA2:0002135 +xref: EHDAA:1703 +xref: EMAPA:16408 +xref: TAO:0000789 +xref: ZFA:0000789 is_a: UBERON:0010329 ! paired limb/fin bud mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005419 ! part of pectoral appendage bud @@ -36686,6 +54419,8 @@ relationship: RO:0002202 UBERON:0005729 ! pectoral appendage field [Term] id: UBERON:0003426 name: dermis adipose tissue +def: "An adipose tissue that is part of a dermis [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000798 is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003585 ! dermis connective tissue intersection_of: UBERON:0001013 ! adipose tissue @@ -36694,6 +54429,8 @@ intersection_of: BFO:0000050 UBERON:0002067 ! part of dermis [Term] id: UBERON:0003429 name: abdomen nerve +def: "A nerve that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000521 is_a: UBERON:0003825 ! nerve of abdominal segment intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -36702,6 +54439,8 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0003430 name: neck nerve +def: "A nerve that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000588 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -36710,6 +54449,9 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0003438 name: iris nerve +def: "Any nerve that innervates the iris." [UBERON:cjm] +xref: EMAPA:35449 +xref: MA:0001291 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0001769 ! iris @@ -36718,6 +54460,8 @@ relationship: RO:0002134 UBERON:0001769 ! iris [Term] id: UBERON:0003439 name: nerve of trunk region +def: "A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk)." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000515 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -36726,14 +54470,33 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0003443 name: thoracic cavity nerve +def: "A nerve that is located in a thoracic cavity [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000556 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0001025 UBERON:0002224 ! thoracic cavity relationship: RO:0001025 UBERON:0002224 ! thoracic cavity +[Term] +id: UBERON:0003452 +name: trabecula carnea cardiac muscle tissue +def: "A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36573 +xref: FMA:84428 +xref: MA:0002833 +is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle +intersection_of: UBERON:0001133 ! cardiac muscle tissue +intersection_of: BFO:0000050 UBERON:0002511 ! part of trabecula carnea +relationship: BFO:0000050 UBERON:0002511 ! part of trabecula carnea + [Term] id: UBERON:0003457 name: head bone +def: "A bone that is part of a head [Automatically generated definition]." [OBOL:automatic] +comment: Different sources vary regarding which bones are craniofacial; e.g. hyoid bone +xref: EMAPA:35996 +xref: MA:0000576 +xref: SCTID:118646007 is_a: UBERON:0007914 ! bone of craniocervical region intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -36742,6 +54505,8 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0003458 name: neck bone +def: "A bone that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000584 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -36750,6 +54515,13 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0003462 name: facial bone +def: "A bone that is part of a facial skeleton [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:19019 +xref: EMAPA:35924 +xref: MA:0001482 +xref: MA:0003159 +xref: NCIT:C63706 +xref: SCTID:181799005 is_a: UBERON:0003457 ! head bone is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001474 ! bone element @@ -36759,6 +54531,10 @@ relationship: BFO:0000050 UBERON:0011156 ! part of facial skeleton [Term] id: UBERON:0003463 name: trunk bone +def: "A bone that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36583 +xref: MA:0000512 +xref: SCTID:427358002 is_a: UBERON:0001474 ! bone element is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0001474 ! bone element @@ -36767,25 +54543,49 @@ intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0003469 name: respiratory system artery +def: "An artery that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001804 is_a: UBERON:0001637 ! artery is_a: UBERON:0003643 ! respiratory system arterial blood vessel intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system +[Term] +id: UBERON:0003470 +name: artery of upper lip +def: "The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose." [Wikipedia:Superior_labial_artery] +xref: FMA:49570 +xref: MA:0001917 +xref: SCTID:145137009 +xref: Wikipedia:Superior_labial_artery +is_a: UBERON:0003496 ! head blood vessel +is_a: UBERON:0009657 ! artery of lip +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0001834 ! upper lip +relationship: RO:0002178 UBERON:0001834 ! upper lip +relationship: RO:0002252 UBERON:0001612 ! facial artery + [Term] id: UBERON:0003471 name: artery of lower lip +def: "The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery." [Wikipedia:Inferior_labial_artery] +xref: FMA:49567 +xref: MA:0001916 +xref: SCTID:145036002 +xref: Wikipedia:Inferior_labial_artery is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0009657 ! artery of lip intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0001835 ! lower lip relationship: RO:0002178 UBERON:0001835 ! lower lip relationship: RO:0002252 UBERON:0001612 ! facial artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003473 name: thoracic cavity artery +def: "An artery that is part of a thoracic cavity[cjm]." [https://sourceforge.net/tracker/index.php?func=detail&aid=3317815&group_id=76834&atid=1205376] +xref: MA:0001902 +xref: MESH:D013895 is_a: UBERON:0001637 ! artery is_a: UBERON:0003519 ! thoracic cavity blood vessel intersection_of: UBERON:0001637 ! artery @@ -36794,31 +54594,68 @@ intersection_of: RO:0001025 UBERON:0002224 ! thoracic cavity [Term] id: UBERON:0003476 name: respiratory system venous blood vessel +def: "A vein that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001809 +xref: MA:0001810 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0001004 ! respiratory system relationship: RO:0002179 UBERON:0001004 ! respiratory system +[Term] +id: UBERON:0003477 +name: vein of upper lip +def: "The inferior labial vein is the vein receiving blood from the upper lip." [Wikipedia:Superior_labial_vein] +xref: FMA:52538 +xref: MA:0002255 +xref: SCTID:422755007 +xref: Wikipedia:Superior_labial_vein +is_a: UBERON:0013136 ! vein of lip +intersection_of: UBERON:0001638 ! vein +intersection_of: RO:0002179 UBERON:0001834 ! upper lip +relationship: RO:0002179 UBERON:0001834 ! upper lip + [Term] id: UBERON:0003478 name: vein of lower lip +def: "The inferior labial vein is the vein receiving blood from the lower lip." [Wikipedia:Inferior_labial_vein] +xref: FMA:52541 +xref: MA:0002253 +xref: SCTID:422955002 +xref: Wikipedia:Inferior_labial_vein is_a: UBERON:0013136 ! vein of lip intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0001835 ! lower lip relationship: RO:0002179 UBERON:0001835 ! lower lip -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003479 name: thoracic cavity vein +def: "A vein that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001903 is_a: UBERON:0001638 ! vein is_a: UBERON:0003519 ! thoracic cavity blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: RO:0001025 UBERON:0002224 ! thoracic cavity +[Term] +id: UBERON:0003481 +name: tail vein +def: "A vein that is part of a tail [Automatically generated definition]." [OBOL:automatic, Wikipedia:Tail_vein] +xref: AAO:0011105 +xref: MA:0002233 +xref: Wikipedia:Tail_vein +xref: XAO:0000393 +is_a: UBERON:0001638 ! vein +is_a: UBERON:0003524 ! tail blood vessel +intersection_of: UBERON:0001638 ! vein +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:0003489 name: respiratory system capillary endothelium +def: "An endothelium of capillary that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001808 is_a: UBERON:0001915 ! endothelium of capillary is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001915 ! endothelium of capillary @@ -36828,6 +54665,8 @@ relationship: BFO:0000050 UBERON:0003526 ! part of respiratory system capillary [Term] id: UBERON:0003494 name: respiratory system venule +def: "A venule that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001813 is_a: UBERON:0001979 ! venule is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001979 ! venule @@ -36836,6 +54675,8 @@ intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003495 name: respiratory system arteriole +def: "An arteriole that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001803 is_a: UBERON:0001980 ! arteriole is_a: UBERON:0003643 ! respiratory system arterial blood vessel intersection_of: UBERON:0001980 ! arteriole @@ -36845,6 +54686,10 @@ relationship: BFO:0000050 UBERON:0003469 ! part of respiratory system artery [Term] id: UBERON:0003496 name: head blood vessel +def: "A blood vessel that is part of a head [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36610 +xref: MA:0000575 +xref: SCTID:127865000 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -36853,6 +54698,8 @@ relationship: BFO:0000050 UBERON:0011362 ! part of cranial blood vasculature [Term] id: UBERON:0003497 name: abdomen blood vessel +def: "A blood vessel that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000518 is_a: UBERON:0003835 ! abdominal segment blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -36861,6 +54708,9 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0003498 name: heart blood vessel +def: "A blood vessel that is part of a heart [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35397 +xref: MA:0002483 is_a: UBERON:0003834 ! thoracic segment blood vessel is_a: UBERON:0005985 ! coronary vessel intersection_of: UBERON:0001981 ! blood vessel @@ -36870,6 +54720,9 @@ relationship: BFO:0000050 UBERON:0018674 ! part of heart vasculature [Term] id: UBERON:0003499 name: brain blood vessel +def: "A blood vessel that is part of a brain [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35182 +xref: MA:0002769 is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001981 ! blood vessel @@ -36879,6 +54732,9 @@ relationship: BFO:0000050 UBERON:0008998 ! part of vasculature of brain [Term] id: UBERON:0003500 name: corneal blood vessel +def: "A blood vessel that is part of a cornea [Automatically generated definition]." [https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/tracker/index.php?func=detail&aid=3564332&group_id=36855&atid=440764] +xref: EMAPA:36611 +xref: MA:0001241 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001981 ! blood vessel @@ -36888,6 +54744,13 @@ relationship: BFO:0000050 UBERON:0000964 ! part of cornea [Term] id: UBERON:0003501 name: retina blood vessel +def: "A blood vessel that is part of a retina [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36520 +xref: GAID:509 +xref: MA:0001317 +xref: MESH:D012171 +xref: SCTID:280692003 +xref: XAO:0004153 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001981 ! blood vessel @@ -36898,6 +54761,8 @@ relationship: RO:0002433 UBERON:0000966 ! retina [Term] id: UBERON:0003502 name: neck blood vessel +def: "A blood vessel that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000583 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -36906,6 +54771,10 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0003504 name: respiratory system blood vessel +def: "A blood vessel that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35731 +xref: EMAPA:35995 +xref: MA:0001799 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -36914,6 +54783,9 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003505 name: trachea blood vessel +def: "A blood vessel that is part of a trachea." [OBOL:automatic] +xref: EMAPA:35874 +xref: MA:0001852 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001981 ! blood vessel @@ -36923,6 +54795,10 @@ relationship: BFO:0000050 UBERON:0003126 ! part of trachea [Term] id: UBERON:0003509 name: arterial blood vessel +def: "A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta." [https://orcid.org/0000-0002-6601-2165] +comment: only in MA - supertype of artery, arteriole, aorta. +xref: EMAPA:35144 +xref: MA:0000061 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0004572 ! part of arterial system @@ -36931,6 +54807,8 @@ relationship: BFO:0000050 UBERON:0004572 ! part of arterial system [Term] id: UBERON:0003511 name: iris blood vessel +def: "A blood vessel that is part of a iris [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001290 is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0001981 ! blood vessel @@ -36940,6 +54818,9 @@ relationship: BFO:0000050 UBERON:0004118 ! part of vasculature of iris [Term] id: UBERON:0003512 name: lung blood vessel +def: "A blood vessel that is part of a lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:32867 +xref: MA:0002457 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003504 ! respiratory system blood vessel is_a: UBERON:0003834 ! thoracic segment blood vessel @@ -36951,6 +54832,8 @@ relationship: RO:0002433 UBERON:0002048 ! lung [Term] id: UBERON:0003513 name: trunk blood vessel +def: "A blood vessel that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000511 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -36959,14 +54842,29 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0003519 name: thoracic cavity blood vessel +def: "A blood vessel that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000554 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: RO:0001025 UBERON:0002224 ! thoracic cavity relationship: RO:0001025 UBERON:0002224 ! thoracic cavity +[Term] +id: UBERON:0003524 +name: tail blood vessel +def: "A blood vessel that is part of a tail [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35848 +xref: MA:0000695 +is_a: UBERON:0001981 ! blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:0003526 name: respiratory system capillary +def: "A capillary that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001807 is_a: UBERON:0001982 ! capillary is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001982 ! capillary @@ -36975,14 +54873,34 @@ intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003528 name: brain gray matter +def: "A gray matter that is part of a brain [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35184 +xref: MA:0000810 +xref: NCIT:C49333 is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain +[Term] +id: UBERON:0003534 +name: tail skin +def: "A zone of skin that is part of a tail [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36502 +xref: MA:0000700 +xref: SCTID:67214004 +is_a: UBERON:0000014 ! zone of skin +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:0003536 name: right lung alveolar duct +def: "An alveolar duct that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35819 +xref: MA:0001785 +xref: NCIT:C49277 is_a: UBERON:0002173 ! pulmonary alveolar duct intersection_of: UBERON:0002173 ! pulmonary alveolar duct intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -36991,6 +54909,11 @@ relationship: BFO:0000050 UBERON:0006526 ! part of right lung alveolar system [Term] id: UBERON:0003537 name: left lung alveolar duct +def: "An alveolar duct that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +comment: Mice have 1 left lobe +xref: EMAPA:19183 +xref: MA:0001776 +xref: NCIT:C49250 is_a: UBERON:0002173 ! pulmonary alveolar duct intersection_of: UBERON:0002173 ! pulmonary alveolar duct intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung @@ -36999,6 +54922,11 @@ relationship: BFO:0000050 UBERON:0006525 ! part of left lung alveolar system [Term] id: UBERON:0003538 name: right lung bronchiole +def: "A bronchiole that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35425 +xref: MA:0001787 +xref: NCIT:C49279 +xref: SCTID:200089000 is_a: UBERON:0002186 ! bronchiole intersection_of: UBERON:0002186 ! bronchiole intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -37007,6 +54935,11 @@ relationship: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0003539 name: left lung bronchiole +def: "A bronchiole that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:19000 +xref: MA:0001778 +xref: NCIT:C49252 +xref: SCTID:200484003 is_a: UBERON:0002186 ! bronchiole intersection_of: UBERON:0002186 ! bronchiole intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung @@ -37015,6 +54948,10 @@ relationship: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0003540 name: right lung terminal bronchiole +def: "A terminal bronchiole that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36638 +xref: MA:0001789 +xref: NCIT:C49294 is_a: UBERON:0002187 ! terminal bronchiole is_a: UBERON:0003538 ! right lung bronchiole intersection_of: UBERON:0002187 ! terminal bronchiole @@ -37023,6 +54960,10 @@ intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0003541 name: left lung terminal bronchiole +def: "A terminal bronchiole that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36636 +xref: MA:0001780 +xref: NCIT:C49255 is_a: UBERON:0002187 ! terminal bronchiole is_a: UBERON:0003539 ! left lung bronchiole intersection_of: UBERON:0002187 ! terminal bronchiole @@ -37031,6 +54972,10 @@ intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0003542 name: right lung respiratory bronchiole +def: "A respiratory bronchiole that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36637 +xref: MA:0001788 +xref: NCIT:C49285 is_a: UBERON:0002188 ! respiratory bronchiole is_a: UBERON:0003538 ! right lung bronchiole intersection_of: UBERON:0002188 ! respiratory bronchiole @@ -37039,6 +54984,10 @@ intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0003543 name: left lung respiratory bronchiole +def: "A respiratory bronchiole that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36635 +xref: MA:0001779 +xref: NCIT:C49254 is_a: UBERON:0002188 ! respiratory bronchiole is_a: UBERON:0003539 ! left lung bronchiole intersection_of: UBERON:0002188 ! respiratory bronchiole @@ -37047,6 +54996,8 @@ intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0003566 name: head connective tissue +def: "A portion of connective tissue that is part of a head [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000577 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -37056,6 +55007,8 @@ relationship: RO:0002494 UBERON:0005253 ! head mesenchyme [Term] id: UBERON:0003567 name: abdomen connective tissue +def: "A portion of connective tissue that is part of an abdomen [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000519 is_a: UBERON:0003838 ! abdominal segment connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -37064,6 +55017,8 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0003568 name: neck connective tissue +def: "A portion of connective tissue that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000585 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -37072,6 +55027,10 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0003570 name: respiratory system connective tissue +def: "A portion of connective tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35968 +xref: EMAPA:35977 +xref: MA:0001814 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -37080,16 +55039,20 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003571 name: trachea connective tissue +def: "A portion of connective tissue that is part of a trachea." [OBOL:automatic] +xref: EMAPA:35876 +xref: MA:0001853 is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002494 UBERON:0009505 ! mesenchyme of trachea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003580 name: lower respiratory tract connective tissue +def: "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002409 is_a: UBERON:0003570 ! respiratory system connective tissue is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0002384 ! connective tissue @@ -37099,6 +55062,9 @@ relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract [Term] id: UBERON:0003585 name: dermis connective tissue +def: "A portion of connective tissue that is part of a dermis [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36509 +xref: MA:0000799 is_a: UBERON:0002384 ! connective tissue is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002384 ! connective tissue @@ -37109,6 +55075,8 @@ relationship: RO:0002202 UBERON:0004016 ! dermatome [Term] id: UBERON:0003586 name: trunk connective tissue +def: "A portion of connective tissue that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000513 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -37117,6 +55085,11 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0003592 name: bronchus connective tissue +def: "A portion of connective tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:32690 +xref: EMAPA:35193 +xref: MA:0001831 +xref: NCIT:C49210 is_a: UBERON:0003580 ! lower respiratory tract connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus @@ -37125,14 +55098,29 @@ relationship: BFO:0000050 UBERON:0002185 ! part of bronchus [Term] id: UBERON:0003593 name: thoracic cavity connective tissue +def: "A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000555 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0001025 UBERON:0002224 ! thoracic cavity relationship: RO:0001025 UBERON:0002224 ! thoracic cavity +[Term] +id: UBERON:0003599 +name: tail connective tissue +def: "A portion of connective tissue that is part of a tail [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:16749 +xref: MA:0000697 +is_a: UBERON:0002384 ! connective tissue +intersection_of: UBERON:0002384 ! connective tissue +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:0003601 name: neck cartilage +def: "A cartilage that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000586 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0000974 ! part of neck @@ -37141,6 +55129,9 @@ relationship: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0003603 name: lower respiratory tract cartilage +def: "A cartilage that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001819 +xref: NCIT:C49256 is_a: UBERON:0003406 ! cartilage of respiratory system is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0007844 ! cartilage element @@ -37150,16 +55141,25 @@ relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract [Term] id: UBERON:0003604 name: trachea cartilage +def: "The ring-shaped cartilaginous structures that support the trachea." [http://orcid.org/0000-0002-6601-2165, J:97123, MGI:smb, MP:0003120] +xref: EMAPA:18699 +xref: EMAPA:35875 +xref: FMA:7434 +xref: MA:0001857 +xref: NCIT:C49304 +xref: SCTID:278979006 +xref: Wikipedia:Tracheal_rings is_a: UBERON:0003603 ! lower respiratory tract cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 UBERON:0007267 ! trachea pre-cartilage rings -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003605 name: eye skin gland +def: "A skin gland that is part of a camera-type eye [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002451 is_a: UBERON:0002419 ! skin gland is_a: UBERON:0004859 ! eye gland is_a: UBERON:0015152 ! gland of ocular region @@ -37170,6 +55170,8 @@ relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye [Term] id: UBERON:0003609 name: aorta elastic tissue +def: "The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall." [MP:0009862] +xref: MA:0002859 is_a: UBERON:0003614 ! blood vessel elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta @@ -37178,6 +55180,8 @@ relationship: BFO:0000050 UBERON:0000947 ! part of aorta [Term] id: UBERON:0003610 name: heart elastic tissue +def: "The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers." [MP:0009863] +xref: MA:0002858 is_a: UBERON:0003613 ! cardiovascular system elastic tissue is_a: UBERON:0003837 ! thoracic segment connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure @@ -37188,6 +55192,8 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: UBERON:0003611 name: respiratory system elastic tissue +def: "An elastic tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001820 is_a: UBERON:0002521 ! elastic tissue is_a: UBERON:0003570 ! respiratory system connective tissue intersection_of: UBERON:0002521 ! elastic tissue @@ -37197,6 +55203,8 @@ relationship: BFO:0000050 UBERON:0004777 ! part of respiratory system submucosa [Term] id: UBERON:0003613 name: cardiovascular system elastic tissue +def: "An elastic tissue that is part of a circulatory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002857 is_a: UBERON:0002521 ! elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0001009 ! part of circulatory system @@ -37205,6 +55213,9 @@ relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system [Term] id: UBERON:0003614 name: blood vessel elastic tissue +def: "Elastic tissue layer that lines a blood vessel layer." [http://orcid.org/0000-0002-6601-2165, https://sourceforge.net/p/obo/mammalian-phenotype-requests/2026/] +xref: EMAPA:36300 +xref: MA:0002856 is_a: UBERON:0003613 ! cardiovascular system elastic tissue is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002521 ! elastic tissue @@ -37214,6 +55225,8 @@ relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel [Term] id: UBERON:0003615 name: lung elastic tissue +def: "Elastic tissue that is part of a lung [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002860 is_a: UBERON:0000114 ! lung connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue @@ -37222,6 +55235,9 @@ intersection_of: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: UBERON:0003616 name: bronchus elastic tissue +def: "An elastic tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001838 +xref: NCIT:C49211 is_a: UBERON:0003592 ! bronchus connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue @@ -37231,16 +55247,22 @@ relationship: BFO:0000050 UBERON:0001957 ! part of submucosa of bronchus [Term] id: UBERON:0003617 name: trachea elastic tissue +def: "An elastic tissue that is part of a trachea [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001861 is_a: UBERON:0003571 ! trachea connective tissue is_a: UBERON:0003611 ! respiratory system elastic tissue intersection_of: UBERON:0002521 ! elastic tissue intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0002202 ! part of submucosa of trachea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003618 name: aorta tunica media +def: "The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers." [MP:0009873] +xref: EMAPA:35138 +xref: FMA:74433 +xref: MA:0002903 +xref: SCTID:48467007 is_a: UBERON:0002522 ! tunica media intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta @@ -37250,6 +55272,12 @@ relationship: RO:0002433 UBERON:0004663 ! aorta wall [Term] id: UBERON:0003619 name: aorta tunica intima +def: "The innermost layer of the aorta, containing the endothelium and an inner elastic membrane." [MP:0009872] +xref: BTO:0005553 +xref: EMAPA:35137 +xref: FMA:74419 +xref: MA:0002904 +xref: SCTID:362031007 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004797 ! blood vessel layer intersection_of: UBERON:0002523 ! tunica intima @@ -37260,14 +55288,41 @@ relationship: RO:0002433 UBERON:0004663 ! aorta wall [Term] id: UBERON:0003643 name: respiratory system arterial blood vessel +def: "An arterial blood vessel that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001800 is_a: UBERON:0003504 ! respiratory system blood vessel is_a: UBERON:0003509 ! arterial blood vessel intersection_of: UBERON:0003509 ! arterial blood vessel intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system +[Term] +id: UBERON:0003665 +name: post-anal tail muscle +def: "A muscle organ that attaches to a tail vertebra [Automatically generated definition]." [OBOL:automatic] +xref: AAO:0000081 +xref: BTO:0001905 +xref: MA:0000699 +xref: SCTID:113230005 +is_a: UBERON:0004518 ! muscle of vertebral column +intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate +intersection_of: RO:0002371 UBERON:0001095 ! caudal vertebra +relationship: RO:0002131 UBERON:0007812 ! overlaps post-anal tail +relationship: RO:0002371 UBERON:0001095 ! caudal vertebra + [Term] id: UBERON:0003684 name: abdominal cavity +def: "The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity)." [UBERON:cjm] +xref: EFO:0000213 +xref: EMAPA:36505 +xref: FMA:12266 +xref: GAID:17 +xref: galen:AbdominalCavity +xref: MA:0003057 +xref: MESH:D034841 +xref: NCIT:C12664 +xref: SCTID:361294009 +xref: Wikipedia:Abdominal_cavity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen @@ -37278,31 +55333,131 @@ relationship: RO:0002572 UBERON:0000916 ! abdomen [Term] id: UBERON:0003687 name: foramen magnum +def: "In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]." [Wikipedia:Foramen_magnum] +comment: Design pattern notes: check whether this fits the foramen design pattern +xref: AAO:0010826 +xref: FMA:75306 +xref: GAID:228 +xref: MESH:D005539 +xref: NCIT:C12495 +xref: SCTID:244679008 +xref: TAO:0002045 +xref: Wikipedia:Foramen_magnum +xref: ZFA:0005387 is_a: UBERON:0013685 ! foramen of skull intersection_of: UBERON:0013685 ! foramen of skull intersection_of: RO:0002570 UBERON:0001896 ! medulla oblongata relationship: RO:0001025 UBERON:0001676 ! occipital bone relationship: RO:0002570 UBERON:0001896 ! medulla oblongata +[Term] +id: UBERON:0003694 +name: atlanto-axial joint +def: "The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas." [Wikipedia:Atlanto-axial_joint] +xref: FMA:25524 +xref: GAID:250 +xref: MESH:D001268 +xref: NCIT:C32157 +xref: SCTID:361832004 +xref: Wikipedia:Atlanto-axial_joint +is_a: UBERON:0000982 ! skeletal joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: RO:0002176 UBERON:0001092 ! vertebral bone 1 +intersection_of: RO:0002176 UBERON:0001093 ! vertebral bone 2 +relationship: BFO:0000050 UBERON:0011138 ! part of postcranial axial skeletal system +relationship: RO:0002176 UBERON:0001092 ! vertebral bone 1 +relationship: RO:0002176 UBERON:0001093 ! vertebral bone 2 + [Term] id: UBERON:0003697 name: abdominal wall +def: "The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles." [ncithesaurus:Abdominal_Wall] +xref: FMA:10429 +xref: FMA:259054 +xref: GAID:26 +xref: MESH:D034861 +xref: NCIT:C77608 +xref: SCTID:181613000 +xref: Wikipedia:Abdominal_wall is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen relationship: BFO:0000050 UBERON:0000916 ! part of abdomen +[Term] +id: UBERON:0003703 +name: extrahepatic bile duct +def: "Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct." [MESH:A03.159.183.079] +xref: FMA:14678 +xref: GAID:281 +xref: MA:0002659 +xref: MESH:D017734 +xref: NCIT:C32573 +xref: SCTID:276158002 +is_a: UBERON:0002394 ! bile duct + +[Term] +id: UBERON:0003704 +name: intrahepatic bile duct +def: "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct." [MESH:A03.159.183.158] +xref: FMA:15766 +xref: GAID:287 +xref: MA:0001630 +xref: MESH:D001653 +xref: NCIT:C12677 +xref: SCTID:362193005 +xref: TAO:0005169 +xref: ZFA:0005169 +is_a: UBERON:0002394 ! bile duct +intersection_of: UBERON:0002394 ! bile duct +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver +relationship: RO:0002433 UBERON:0002107 ! liver + [Term] id: UBERON:0003711 name: brachiocephalic vein +def: "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava." [Wikipedia:Brachiocephalic_vein] +xref: EHDAA2:0000182 +xref: EHDAA:9868 +xref: FMA:4723 +xref: GAID:529 +xref: galen:BrachiocephalicVein +xref: MESH:D016121 +xref: NCIT:C32816 +xref: SCTID:181371003 +xref: Wikipedia:Brachiocephalic_vein is_a: UBERON:0001638 ! vein relationship: BFO:0000050 UBERON:0007204 ! part of brachiocephalic vasculature relationship: RO:0002170 UBERON:0001585 ! anterior vena cava -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0003713 +name: splenic vein +def: "A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein." [ncithesaurus:Splenic_Vein] +xref: FMA:14331 +xref: GAID:541 +xref: galen:SplenicVein +xref: MA:0002164 +xref: MESH:D013162 +xref: NCIT:C33608 +xref: SCTID:278029005 +xref: Wikipedia:Splenic_vein +is_a: UBERON:0001638 ! vein +relationship: RO:0002170 UBERON:0001639 ! hepatic portal vein [Term] id: UBERON:0003714 name: neural tissue +def: "Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature." [FMA:9642] +xref: AAO:0000325 +xref: AEO:0000123 +xref: EHDAA2:0003123 +xref: FMA:9642 +xref: GAID:609 +xref: MESH:D009417 +xref: NCIT:C13052 +xref: SCTID:91728009 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000051 CL:0000125 ! has part glial cell @@ -37315,30 +55470,60 @@ relationship: BFO:0000051 CL:0000540 ! has part neuron [Term] id: UBERON:0003715 name: splanchnic nerve +def: "The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia." [MP:0008318] +xref: BAMS:spn +xref: FMA:5883 +xref: GAID:800 +xref: MESH:D013153 +xref: SCTID:264198001 +xref: Wikipedia:Splanchnic_nerves is_a: UBERON:0034729 ! sympathetic nerve intersection_of: UBERON:0001021 ! nerve intersection_of: RO:0002134 UBERON:0000916 ! abdomen relationship: RO:0002134 UBERON:0000916 ! abdomen relationship: RO:0002433 UBERON:0000013 ! sympathetic nervous system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003726 name: thoracic nerve +def: "The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls." [MESH:A08.800.800.720.800] +xref: FMA:5860 +xref: GAID:857 +xref: MESH:D013900 +xref: neuronames:1725 +xref: SCTID:360498003 +xref: Wikipedia:Thoracic_nerves is_a: UBERON:0001780 ! spinal nerve intersection_of: UBERON:0001780 ! spinal nerve intersection_of: extends_fibers_into UBERON:0003038 ! thoracic spinal cord relationship: extends_fibers_into UBERON:0003038 ! thoracic spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003727 name: intercostal nerve +def: "The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]." [Wikipedia:Intercostal_nerves] +xref: EMAPA:18227 +xref: FMA:6028 +xref: GAID:858 +xref: MESH:D007367 +xref: NCIT:C32825 +xref: SCTID:279568001 +xref: Wikipedia:Intercostal_nerves is_a: UBERON:0001780 ! spinal nerve [Term] id: UBERON:0003729 name: mouth mucosa +def: "A mucous membrane that lines the mouth." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0002860 +xref: CALOHA:TS-0716 +xref: EMAPA:26937 +xref: FMA:59660 +xref: GAID:951 +xref: MA:0002794 +xref: MESH:D009061 +xref: NCIT:C77637 +xref: Wikipedia:Oral_mucosa is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0000165 ! part of mouth @@ -37351,6 +55536,10 @@ relationship: RO:0002433 UBERON:0001007 ! digestive system [Term] id: UBERON:0003824 name: nerve of thoracic segment +def: "A nerve that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000562 +xref: MESH:D013900 +xref: SCTID:359876006 is_a: UBERON:0003439 ! nerve of trunk region intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -37359,6 +55548,8 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0003825 name: nerve of abdominal segment +def: "A nerve that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000528 is_a: UBERON:0003439 ! nerve of trunk region intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -37367,6 +55558,9 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003827 name: thoracic segment bone +def: "A bone that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000559 +xref: SCTID:426649006 is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0001474 ! bone element @@ -37375,6 +55569,8 @@ intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0003828 name: abdominal segment bone +def: "A bone that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000525 is_a: UBERON:0003463 ! trunk bone is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0001474 ! bone element @@ -37383,6 +55579,8 @@ intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003830 name: thoracic segment muscle +def: "Any muscle organ that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000561 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate @@ -37392,6 +55590,9 @@ relationship: BFO:0000050 UBERON:0004464 ! part of musculature of thorax [Term] id: UBERON:0003831 name: respiratory system muscle +def: "Any muscle organ that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35733 +xref: MA:0001828 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -37400,6 +55601,10 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0003832 name: esophagus muscle +def: "Any muscle organ that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:26983 +xref: MA:0002682 +xref: SCTID:360961009 is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0005181 ! thoracic segment organ is_a: UBERON:0013765 ! digestive system element @@ -37410,6 +55615,8 @@ relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus [Term] id: UBERON:0003833 name: abdominal segment muscle +def: "A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000527 is_a: UBERON:0001774 ! skeletal muscle of trunk is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate @@ -37418,6 +55625,8 @@ intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003834 name: thoracic segment blood vessel +def: "A blood vessel that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000558 is_a: UBERON:0003513 ! trunk blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -37426,6 +55635,8 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0003835 name: abdominal segment blood vessel +def: "A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000524 is_a: UBERON:0003513 ! trunk blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -37434,6 +55645,9 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003836 name: abdominal segment skin +def: "A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: FMA:264898 +xref: MA:0000530 is_a: UBERON:0001085 ! skin of trunk intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -37442,6 +55656,8 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003837 name: thoracic segment connective tissue +def: "A portion of connective tissue that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000560 is_a: UBERON:0003586 ! trunk connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -37450,6 +55666,8 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0003838 name: abdominal segment connective tissue +def: "A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000526 is_a: UBERON:0003586 ! trunk connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -37458,6 +55676,14 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0003842 name: neural tube lumen +def: "An anatomical space that surrounded_by a neural tube." [OBOL:automatic] +xref: AAO:0011073 +xref: EHDAA2:0001269 +xref: EHDAA:2889 +xref: EHDAA:914 +xref: EMAPA:16167 +xref: VHOG:0001119 +xref: XAO:0000252 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001049 ! neural tube @@ -37467,6 +55693,12 @@ relationship: RO:0002572 UBERON:0001049 ! neural tube [Term] id: UBERON:0003848 name: gonadal vein +def: "In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]." [Wikipedia:Gonadal_vein] +xref: EHDAA2:0000719 +xref: EHDAA:8703 +xref: SCTID:278192008 +xref: VHOG:0001340 +xref: Wikipedia:Gonadal_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002371 UBERON:0000991 ! gonad @@ -37475,6 +55707,13 @@ relationship: RO:0002371 UBERON:0000991 ! gonad [Term] id: UBERON:0003849 name: mesencephalic neural crest +def: "A neural crest that has_potential_to_developmentally_contribute_to a midbrain." [OBOL:automatic] +xref: EFO:0003591 +xref: EHDAA2:0001101 +xref: EHDAA:360 +xref: TAO:0000935 +xref: VHOG:0000796 +xref: ZFA:0000935 is_a: UBERON:0002342 ! neural crest is_a: UBERON:0003099 ! cranial neural crest intersection_of: UBERON:0002342 ! neural crest @@ -37484,6 +55723,13 @@ relationship: RO:0002385 UBERON:0001891 ! midbrain [Term] id: UBERON:0003852 name: rhombencephalon neural crest +def: "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain." [OBOL:automatic] +xref: EHDAA2:0001628 +xref: EHDAA:362 +xref: EMAPA:35747 +xref: TAO:0007063 +xref: VHOG:0001210 +xref: ZFA:0007063 is_a: UBERON:0002342 ! neural crest is_a: UBERON:0003099 ! cranial neural crest intersection_of: UBERON:0002342 ! neural crest @@ -37493,6 +55739,11 @@ relationship: RO:0002385 UBERON:0002028 ! hindbrain [Term] id: UBERON:0003853 name: spinal cord neural crest +def: "A neural crest that has_potential_to_developmentally_contribute_to a spinal cord." [OBOL:automatic] +xref: EHDAA:696 +xref: EMAPA:16163 +xref: EMAPA:16881 +xref: VHOG:0001006 is_a: UBERON:0002342 ! neural crest intersection_of: UBERON:0002342 ! neural crest intersection_of: RO:0002385 UBERON:0002240 ! spinal cord @@ -37501,6 +55752,11 @@ relationship: RO:0002385 UBERON:0002240 ! spinal cord [Term] id: UBERON:0003854 name: spinal cord neural plate +def: "A neural plate that develops_from a future spinal cord." [OBOL:automatic] +xref: FMA:312957 +xref: TAO:0007021 +xref: VHOG:0000439 +xref: ZFA:0007021 is_a: UBERON:0003075 ! neural plate intersection_of: UBERON:0003075 ! neural plate intersection_of: RO:0002202 UBERON:0006241 ! future spinal cord @@ -37509,6 +55765,11 @@ relationship: RO:0002202 UBERON:0006241 ! future spinal cord [Term] id: UBERON:0003855 name: gonad mesenchyme +def: "Mesenchyme that is part of a developing gonad [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA:5012 +xref: EMAPA:16858 +xref: EMAPA:17385 +xref: VHOG:0001090 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003104 ! mesenchyme @@ -37518,6 +55779,7 @@ relationship: BFO:0000050 UBERON:0000991 ! part of gonad [Term] id: UBERON:0003869 name: presumptive ganglion +def: "A presumptive structure that has the potential to develop into a ganglion." [OBOL:automatic] is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0000045 ! ganglion @@ -37526,6 +55788,7 @@ relationship: RO:0002387 UBERON:0000045 ! ganglion [Term] id: UBERON:0003886 name: future coelemic cavity lumen +def: "An anatomical cavity that has the potential to develop into a coelemic cavity lumen." [OBOL:automatic] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002387 UBERON:0002323 ! coelemic cavity lumen @@ -37537,6 +55800,12 @@ relationship: RO:0002492 UBERON:0000111 ! organogenesis stage [Term] id: UBERON:0003887 name: intraembryonic coelom +def: "The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom." [MGI:anna, MP:0012187] +xref: EHDAA:251 +xref: EMAPA:16088 +xref: NCIT:C34195 +xref: VHOG:0000316 +xref: Wikipedia:Intraembryonic_coelom is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0011997 ! part of coelom relationship: RO:0002202 UBERON:0003081 ! lateral plate mesoderm @@ -37544,13 +55813,44 @@ relationship: RO:0002202 UBERON:0003081 ! lateral plate mesoderm [Term] id: UBERON:0003891 name: stroma +def: "Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:81494 +xref: NCIT:C67387 is_a: UBERON:0000064 ! organ part relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa relationship: RO:0002473 UBERON:0002384 ! connective tissue +[Term] +id: UBERON:0003894 +name: liver primordium +def: "A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum." [ISBN:3211492755] +xref: AAO:0011058 +xref: BTO:0003391 +xref: EFO:0002577 +xref: EFO:0003428 +xref: EHDAA2:0000744 +xref: EHDAA:973 +xref: EMAPA:16847 +xref: NCIT:C34277 +xref: TAO:0000124 +xref: XAO:0003266 +xref: ZFA:0000124 +is_a: UBERON:0000485 ! simple columnar epithelium +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0006598 ! presumptive structure +is_a: UBERON:0009497 ! epithelium of foregut-midgut junction +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0002107 ! liver +relationship: BFO:0000050 UBERON:0009550 ! part of endoderm of foregut-midgut junction +relationship: RO:0002202 UBERON:0001041 ! foregut +relationship: RO:0002387 UBERON:0002107 ! liver + [Term] id: UBERON:0003898 name: skeletal muscle tissue of trunk +def: "A portion of skeletal muscle tissue in the trunk." [http://orcid.org/0000-0002-6601-2165] +xref: SCTID:244848007 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -37560,22 +55860,45 @@ relationship: BFO:0000050 UBERON:0013700 ! part of axial musculature [Term] id: UBERON:0003902 name: retinal neural layer +def: "The part of the retina that contains neurons and photoreceptor cells[GO]." [GO:0003407] +xref: AAO:0011095 +xref: BTO:0000929 +xref: CALOHA:TS-0685 +xref: EHDAA2:0001253 +xref: EHDAA:4763 +xref: EMAPA:17171 +xref: EMAPA:18590 +xref: FMA:58628 +xref: MA:0000277 +xref: NCIT:C33166 +xref: TAO:0000046 +xref: VHOG:0000535 +xref: XAO:0003216 +xref: ZFA:0000046 is_a: UBERON:0001781 ! layer of retina intersection_of: UBERON:0001781 ! layer of retina intersection_of: RO:0002495 UBERON:0005425 ! presumptive neural retina relationship: BFO:0000051 CL:0000210 ! has part photoreceptor cell relationship: RO:0002256 UBERON:0005426 ! lens vesicle relationship: RO:0002495 UBERON:0005425 ! presumptive neural retina -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003909 name: sinusoid +def: "Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]." [Wikipedia:Sinusoid_(blood_vessel)] +xref: FMA:63131 +xref: SCTID:340163004 +xref: TAO:0005261 +xref: Wikipedia:Sinusoid_(blood_vessel) +xref: ZFA:0005261 is_a: UBERON:2005260 ! fenestrated capillary [Term] id: UBERON:0003914 name: epithelial tube +def: "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GO:0060562, PMID:12526790] +xref: AEO:0000114 +xref: EHDAA2:0003114 is_a: UBERON:0000025 ! tube is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium @@ -37584,6 +55907,7 @@ intersection_of: RO:0000086 PATO:0002299 [Term] id: UBERON:0003915 name: endothelial tube +def: "Any endothelium that has the quality of being cylindrical [Automatically generated definition]." [OBOL:automatic] is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003914 ! epithelial tube intersection_of: UBERON:0001986 ! endothelium @@ -37592,15 +55916,99 @@ intersection_of: RO:0000086 PATO:0002299 [Term] id: UBERON:0003920 name: venous blood vessel +def: "A blood vessel that carries blood from the capillaries toward the heart." [http://www.thefreedictionary.com/venous+blood+vessel] +comment: Compare to: vein +xref: EMAPA:35932 +xref: FMA:86188 +xref: MA:0000066 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0004582 ! part of venous system relationship: BFO:0000050 UBERON:0004582 ! part of venous system -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0003921 +name: pancreas primordium +def: "Embryonic structure that develops into pancreatic bud." [Wikipedia:Pancreas#Embryological_development] +xref: EFO:0002579 +xref: EFO:0003434 +xref: EHDAA2:0001382 +xref: EHDAA:2163 +xref: EMAPA:17066 +xref: FMA:79792 +xref: TAO:0000254 +xref: XAO:0001101 +xref: ZFA:0000254 +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0001264 ! pancreas +relationship: BFO:0000050 UBERON:0007026 ! part of presumptive gut +relationship: RO:0002202 UBERON:0000925 ! endoderm +relationship: RO:0002387 UBERON:0001264 ! pancreas + +[Term] +id: UBERON:0003922 +name: pancreatic epithelial bud +def: "The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]." [PMID:16417468, Wikipedia:Pancreatic_bud] +xref: EFO:0003470 +xref: EMAPA:35645 +xref: NCIT:C34242 +xref: SCTID:360398004 +xref: TAO:0001390 +xref: Wikipedia:Pancreatic_bud +xref: ZFA:0001390 +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0007499 ! epithelial sac +relationship: BFO:0000050 UBERON:0003921 ! part of pancreas primordium +relationship: RO:0002202 UBERON:0001041 ! foregut +relationship: RO:0002202 UBERON:0001555 ! digestive tract +relationship: RO:0002202 UBERON:0002114 ! duodenum +relationship: RO:0002202 UBERON:0009497 ! epithelium of foregut-midgut junction + +[Term] +id: UBERON:0003923 +name: dorsal pancreatic bud +def: "Pancreatic bud that gives rise to the accessory pancreatic duct." [Wikipedia:Pancreatic_bud] +xref: AAO:0011031 +xref: EFO:0003465 +xref: EHDAA2:0001385 +xref: EMAPA:17067 +xref: SCTID:361435005 +xref: TAO:0001370 +xref: VHOG:0001428 +xref: Wikipedia:Pancreatic_bud +xref: XAO:0000467 +xref: ZFA:0001370 +is_a: UBERON:0003922 ! pancreatic epithelial bud +relationship: BFO:0000050 UBERON:0010375 ! part of pancreas dorsal primordium +relationship: RO:0002202 UBERON:0001045 ! midgut + +[Term] +id: UBERON:0003924 +name: ventral pancreatic bud +def: "Pancreatic bud that gives rise to the major pancreatic duct." [Wikipedia:Pancreatic_bud] +xref: AAO:0011111 +xref: EFO:0003464 +xref: EHDAA2:0001389 +xref: EMAPA:17256 +xref: SCTID:361437002 +xref: TAO:0001369 +xref: VHOG:0001429 +xref: Wikipedia:Pancreatic_bud +xref: XAO:0001103 +xref: ZFA:0001369 +is_a: UBERON:0003922 ! pancreatic epithelial bud +relationship: BFO:0000050 UBERON:0010376 ! part of pancreas ventral primordium +relationship: RO:0002202 UBERON:0008835 ! hepatic diverticulum [Term] id: UBERON:0003928 name: digestive system duct +def: "A duct that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] +xref: TAO:0005162 +xref: ZFA:0005162 is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system @@ -37609,6 +56017,15 @@ relationship: BFO:0000050 UBERON:0001007 ! part of digestive system [Term] id: UBERON:0003929 name: digestive tract epithelium +def: "An epithelium that lines the lumen of the digestive tract." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000956 +xref: EHDAA2:0004567 +xref: EMAPA:32928 +xref: MA:0003201 +xref: NCIT:C12963 +xref: TAO:0005123 +xref: XAO:0003200 +xref: ZFA:0005123 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract @@ -37617,6 +56034,10 @@ relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: UBERON:0003932 name: cartilage element of chondrocranium +def: "A cartilage element of chondrocranium. Example: neurocranial trabecula." [https://orcid.org/0000-0002-6601-2165] +xref: EFO:0003690 +xref: TAO:0001461 +xref: ZFA:0001461 is_a: UBERON:0003933 ! cranial cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0002241 ! part of chondrocranium @@ -37625,6 +56046,9 @@ relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium [Term] id: UBERON:0003933 name: cranial cartilage +def: "A cartilage element that is part of the cranial skeleton." [https://orcid.org/0000-0002-6601-2165, ZFA:0001458] +xref: TAO:0001458 +xref: ZFA:0001458 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system @@ -37633,6 +56057,8 @@ relationship: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system [Term] id: UBERON:0003937 name: reproductive gland +def: "Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction." [MP:0000653] +xref: MA:0001751 is_a: UBERON:0002530 ! gland is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0002530 ! gland @@ -37641,6 +56067,10 @@ intersection_of: BFO:0000050 UBERON:0000990 ! part of reproductive system [Term] id: UBERON:0003942 name: somatosensory system +def: "The sensory system for the sense of touch and pain." [NLXANAT:090818] +xref: neuronames:2887 +xref: NLXANAT:090818 +xref: Wikipedia:Somatosensory_system is_a: UBERON:0001032 ! sensory system relationship: RO:0002216 GO:0019233 ! capable of part of sensory perception of pain relationship: RO:0002216 GO:0050975 ! capable of part of sensory perception of touch @@ -37648,6 +56078,7 @@ relationship: RO:0002216 GO:0050975 ! capable of part of sensory perception of t [Term] id: UBERON:0003952 name: anterior stroma of cornea +def: "The anterior segment of the lamellated connective tissue layer of the cornea." [MP:0003093] is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002384 ! connective tissue @@ -37655,11 +56086,11 @@ intersection_of: BSPO:0000123 UBERON:0001777 ! substantia propria of cornea relationship: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea relationship: BSPO:0000123 UBERON:0001777 ! substantia propria of cornea relationship: RO:0002433 UBERON:0001777 ! substantia propria of cornea -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0003953 name: posterior stroma of cornea +def: "The posterior segment of the lamellated connective tissue layer of the cornea." [MP:0003094] is_a: UBERON:0003566 ! head connective tissue is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002384 ! connective tissue @@ -37671,6 +56102,7 @@ relationship: RO:0002433 UBERON:0001777 ! substantia propria of cornea [Term] id: UBERON:0003967 name: cutaneous elastic tissue +def: "The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity." [MP:0008418] is_a: UBERON:0002521 ! elastic tissue is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0002521 ! elastic tissue @@ -37681,15 +56113,20 @@ relationship: RO:0002433 UBERON:0000014 ! zone of skin [Term] id: UBERON:0003975 name: internal female genitalia +def: "The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina." [MP:0009209] +comment: TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 +xref: BTO:0003099 +xref: FMA:45654 +xref: SCTID:303518005 is_a: UBERON:0003134 ! female reproductive organ is_a: UBERON:0004175 ! internal genitalia intersection_of: UBERON:0004175 ! internal genitalia intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004015 name: embryonic-extraembryonic boundary +def: "The connection between the embryo proper and extraembryonic tissues." [MP:0003890] is_a: UBERON:0000015 ! non-material anatomical boundary intersection_of: UBERON:0000015 ! non-material anatomical boundary intersection_of: RO:0002220 UBERON:0000478 ! adjacent to extraembryonic structure @@ -37700,12 +56137,26 @@ relationship: RO:0002220 UBERON:0002050 ! adjacent to embryonic structure [Term] id: UBERON:0004016 name: dermatome +def: "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells." [AEO:0001017, AEO:JB] +xref: AAO:0011028 +xref: AEO:0001017 +xref: EHDAA2_RETIRED:0003428 +xref: EHDAA:1719 +xref: EHDAA:1725 +xref: EHDAA:1731 +xref: EHDAA:1737 +xref: EMAPA:32838 +xref: FMA:295656 +xref: NCIT:C61572 +xref: Wikipedia:Dermatome_(embryology) +xref: XAO:0000220 is_a: UBERON:0017650 ! developing mesenchymal structure relationship: RO:0002202 UBERON:0004290 ! dermomyotome [Term] id: UBERON:0004022 name: germinal neuroepithelium +def: "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0004261] is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0034706 ! proliferating neuroepithelium @@ -37714,9 +56165,27 @@ relationship: BFO:0000050 UBERON:0001049 ! part of neural tube relationship: RO:0002007 UBERON:0001049 ! bounding layer of neural tube relationship: RO:0002220 UBERON:0003842 ! adjacent to neural tube lumen +[Term] +id: UBERON:0004058 +name: biliary ductule +def: "One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]." [BTO:0002840, MP:0009494] +xref: BTO:0002840 +xref: TAO:0005164 +xref: ZFA:0005164 +is_a: UBERON:0000025 ! tube +is_a: UBERON:0004119 ! endoderm-derived structure +relationship: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002394 ! part of bile duct +relationship: RO:0002220 UBERON:0001175 ! adjacent to common hepatic duct + [Term] id: UBERON:0004060 name: neural tube ventricular layer +def: "The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009689] +xref: EMAPA:17152 +xref: EMAPA:35362 +xref: EMAPA_RETIRED:16783 +xref: MA:0003193 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0034706 ! proliferating neuroepithelium @@ -37727,6 +56196,10 @@ relationship: RO:0002495 UBERON:0004022 ! germinal neuroepithelium [Term] id: UBERON:0004061 name: neural tube mantle layer +def: "The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009690] +xref: EMAPA:17148 +xref: EMAPA:35360 +xref: neuronames:1367 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium is_a: UBERON:0034707 ! differentiating neuroepithelium @@ -37738,6 +56211,9 @@ relationship: RO:0002220 UBERON:0004062 ! adjacent to neural tube marginal layer [Term] id: UBERON:0004062 name: neural tube marginal layer +def: "The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009691] +xref: EMAPA:17151 +xref: neuronames:1368 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005162 ! multi cell part structure relationship: BFO:0000050 UBERON:0001049 ! part of neural tube @@ -37747,6 +56223,12 @@ relationship: RO:0002220 UBERON:0004061 ! adjacent to neural tube mantle layer [Term] id: UBERON:0004064 name: neural tube basal plate +def: "The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons." [http://www.ncbi.nlm.nih.gov/books/NBK10047, MP:0009693, Wikipedia:Basal_plate_(neural_tube)] +xref: AAO:0010561 +xref: EFO:0001904 +xref: NCIT:C34111 +xref: neuronames:1372 +xref: Wikipedia:Basal_plate_(neural_tube) is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0004061 ! part of neural tube mantle layer @@ -37755,21 +56237,82 @@ relationship: BSPO:0000102 UBERON:0005478 ! sulcus limitans of neural tube relationship: RO:0002256 UBERON:0002328 ! notochord relationship: RO:0002433 UBERON:0004061 ! neural tube mantle layer +[Term] +id: UBERON:0004066 +name: frontonasal prominence +def: "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout." [MP:0009901] +xref: EHDAA2:0000578 +xref: EHDAA:4778 +xref: EMAPA:16681 +xref: FMA:293101 +xref: NCIT:C34182 +xref: SCTID:361486000 +xref: VHOG:0001319 +xref: Wikipedia:Frontonasal_prominence +is_a: UBERON:0009292 ! embryonic nasal process +relationship: BSPO:0005001 UBERON:0000033 ! head + +[Term] +id: UBERON:0004068 +name: medial nasal prominence +def: "The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it." [MP:0009903, Wikipedia:Medial_nasal_prominence] +xref: EHDAA2:0001076 +xref: EHDAA:4792 +xref: EMAPA:16808 +xref: FMA:295858 +xref: SCTID:308877001 +xref: VHOG:0000804 +xref: Wikipedia:Medial_nasal_prominence +is_a: UBERON:0009292 ! embryonic nasal process +relationship: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence +relationship: BSPO:0000126 UBERON:0008816 ! embryonic head +relationship: RO:0002202 UBERON:0004066 ! frontonasal prominence + [Term] id: UBERON:0004087 name: vena cava +def: "Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Venae_cavae] +xref: AAO:0010215 +xref: BTO:0001438 +xref: EMAPA:18415 +xref: FMA:321896 +xref: GAID:547 +xref: MA:0000068 +xref: MESH:D014684 +xref: NCIT:C12817 +xref: SCTID:244405007 +xref: Wikipedia:Venae_cavae is_a: UBERON:0003479 ! thoracic cavity vein is_a: UBERON:0013768 ! great vessel of heart [Term] id: UBERON:0004088 name: orbital region +def: "The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:260119 +is_a: UBERON:0001444 ! subdivision of head +relationship: BFO:0000050 UBERON:0001456 ! part of face + +[Term] +id: UBERON:0004089 +name: midface +def: "The middle of the face including the nose and its associated bony structures[MW]." [HP:0000309, http://www.merriam-webster.com/medical/midface] +xref: FMA:285406 +xref: MA:0001910 is_a: UBERON:0001444 ! subdivision of head relationship: BFO:0000050 UBERON:0001456 ! part of face +relationship: RO:0002160 NCBITaxon:89593 ! Craniata +relationship: RO:0002433 UBERON:0001456 ! face [Term] id: UBERON:0004111 name: anatomical conduit +def: "Any tube, opening or passage that connects two distinct anatomical spaces." [http://orcid.org/0000-0002-6601-2165] +xref: AEO:0000080 +xref: EHDAA2:0003080 +xref: FMA:242873 +xref: SCTID:346902003 +xref: Wikipedia:Foramen is_a: UBERON:0010000 ! multicellular anatomical structure intersection_of: UBERON:0010000 ! multicellular anatomical structure intersection_of: BFO:0000051 UBERON:0013686 ! has part anatomical conduit space @@ -37777,13 +56320,12 @@ intersection_of: RO:0002570 UBERON:0000061 ! anatomical structure relationship: BFO:0000051 UBERON:0013686 ! has part anatomical conduit space relationship: RO:0002176 UBERON:0000464 {cardinality="2"} ! anatomical space relationship: RO:0002570 UBERON:0000061 ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0004118 name: vasculature of iris +def: "A vasculature that is part of a iris [Automatically generated definition]." [OBOL:automatic] +xref: ZFA:0005568 is_a: UBERON:0002203 ! vasculature of eye intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001769 ! part of iris @@ -37792,6 +56334,7 @@ relationship: BFO:0000050 UBERON:0001769 ! part of iris [Term] id: UBERON:0004119 name: endoderm-derived structure +def: "An anatomical structure that develops (entirely or partially) from the endoderm." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0000925 ! endoderm @@ -37800,6 +56343,7 @@ relationship: RO:0002202 UBERON:0000925 ! endoderm [Term] id: UBERON:0004120 name: mesoderm-derived structure +def: "An anatomical structure that develops (entirely or partially) from the mesoderm." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0000926 ! mesoderm @@ -37808,14 +56352,93 @@ relationship: RO:0002202 UBERON:0000926 ! mesoderm [Term] id: UBERON:0004121 name: ectoderm-derived structure +def: "An anatomical structure that develops (entirely or partially) from the ectoderm." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002202 UBERON:0000924 ! ectoderm relationship: RO:0002202 UBERON:0000924 ! ectoderm +[Term] +id: UBERON:0004122 +name: genitourinary system +def: "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction." [VHOG:0000286] +xref: AAO:0000624 +xref: BILA:0000122 +xref: BTO:0003091 +xref: EFO:0003864 +xref: EHDAA:1013 +xref: EMAPA:16367 +xref: EV:0100094 +xref: FMA:280610 +xref: GAID:362 +xref: galen:GenitoUrinarySystem +xref: MESH:D014566 +xref: NCIT:C12810 +xref: SCTID:278861008 +xref: VHOG:0000286 +xref: XAO:0000140 +is_a: UBERON:0000467 ! anatomical system +intersection_of: UBERON:0000467 ! anatomical system +intersection_of: BFO:0000051 UBERON:0000990 ! has part reproductive system +intersection_of: BFO:0000051 UBERON:0001008 ! has part renal system +relationship: BFO:0000051 UBERON:0000990 ! has part reproductive system +relationship: BFO:0000051 UBERON:0001008 ! has part renal system +relationship: RO:0002492 UBERON:0000066 ! fully formed stage + +[Term] +id: UBERON:0004123 +name: myocardial layer +def: "Any of the layers of the myocardium. Example: compact layer, trabecular layer." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000080 +is_a: UBERON:0005983 ! heart layer +intersection_of: UBERON:0004923 ! organ component layer +intersection_of: layer_part_of UBERON:0002349 ! myocardium +relationship: BFO:0000050 UBERON:0002349 ! part of myocardium +relationship: layer_part_of UBERON:0002349 ! myocardium + +[Term] +id: UBERON:0004124 +name: myocardium trabecular layer +def: "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA]." [ZFA:0005059] +xref: EFO:0003706 +xref: MA:0002866 +xref: TAO:0005059 +xref: ZFA:0005059 +is_a: UBERON:0004123 ! myocardial layer +intersection_of: UBERON:0004123 ! myocardial layer +intersection_of: RO:0002220 UBERON:0002165 ! adjacent to endocardium +intersection_of: RO:0002473 GO:0036194 ! muscle cell projection +relationship: RO:0002220 UBERON:0002165 ! adjacent to endocardium +relationship: RO:0002473 GO:0036194 ! muscle cell projection + +[Term] +id: UBERON:0004126 +name: trabecular layer of ventricle +def: "A myocardium trabecular layer that is part of a cardiac ventricle." [OBOL:automatic] +xref: FMA:83511 +xref: TAO:0005060 +xref: ZFA:0005060 +is_a: UBERON:0004124 ! myocardium trabecular layer +intersection_of: UBERON:0004124 ! myocardium trabecular layer +intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle +relationship: BFO:0000050 UBERON:0001083 ! part of myocardium of ventricle + [Term] id: UBERON:0004128 name: optic vesicle +def: "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]." [GO:0003404, Wikipedia:Optic_vesicles] +comment: Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 "Developmental Biology"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288] +xref: AAO:0011039 +xref: EHDAA2:0001320 +xref: EMAPA:16540 +xref: FMA:293357 +xref: NCIT:C34236 +xref: SCTID:362864008 +xref: TAO:0000050 +xref: VHOG:0000165 +xref: Wikipedia:Optic_vesicles +xref: XAO:0000228 +xref: ZFA:0000050 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0010312 ! part of immature eye @@ -37826,6 +56449,7 @@ relationship: RO:0002256 UBERON:0004880 ! chordamesoderm [Term] id: UBERON:0004133 name: salivatory nucleus +def: "Missing definition for term UBERON:0004133. Please replace it using linked reference." [GO:0021751] is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus relationship: BFO:0000050 UBERON:0000988 ! part of pons @@ -37833,12 +56457,18 @@ relationship: BFO:0000050 UBERON:0000988 ! part of pons [Term] id: UBERON:0004139 name: cardiogenic plate +def: "The first recognizable structure derived from the heart field." [GO:0003142] +xref: EHDAA2:0000215 +xref: EMAPA:16106 +xref: VHOG:0000975 is_a: UBERON:0002050 ! embryonic structure relationship: RO:0002202 UBERON:0003084 ! heart primordium [Term] id: UBERON:0004140 name: primary heart field +def: "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [GO:0003138, GOC:mtg_heart, GOC:rl] +xref: XAO:0004185 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -37849,6 +56479,14 @@ relationship: BFO:0000050 UBERON:0036146 ! part of cardiopharyngeal field [Term] id: UBERON:0004141 name: heart tube +def: "An epithelial tube that will give rise to the mature heart." [GO:0003143, GOC:mtg_heart] +xref: AAO:0010411 +xref: EFO:0003526 +xref: EMAPA:32685 +xref: NCIT:C34161 +xref: TAO:0000360 +xref: XAO:0000337 +xref: ZFA:0000360 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0012275 ! meso-epithelium @@ -37857,6 +56495,8 @@ relationship: RO:0002495 UBERON:0005498 ! primitive heart tube [Term] id: UBERON:0004142 name: outflow tract septum +def: "The outflow tract septum is a partition in the outflow tract." [GO:0003148] +xref: XAO:0004141 is_a: UBERON:0002099 ! cardiac septum intersection_of: UBERON:0002099 ! cardiac septum intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract @@ -37865,6 +56505,14 @@ relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract [Term] id: UBERON:0004145 name: outflow tract +def: "The outflow tract is the portion of the heart through which blood flows into the arteries." [GO:0003151] +xref: EHDAA2:0001351 +xref: EHDAA:464 +xref: EHDAA:798 +xref: EMAPA:16346 +xref: MA:0000100 +xref: VHOG:0000670 +xref: XAO:0004139 is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000948 ! part of heart @@ -37875,6 +56523,7 @@ relationship: channels_into UBERON:0001637 ! artery [Term] id: UBERON:0004146 name: His-Purkinje system +def: "The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GO:0003164, https://github.com/geneontology/go-ontology/issues/12451] is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BFO:0000050 UBERON:0002350 ! part of conducting system of heart @@ -37883,6 +56532,15 @@ relationship: RO:0002160 NCBITaxon:32523 ! Tetrapoda [Term] id: UBERON:0004148 name: cardiac vein +def: "Vein of heart that drains the myocardium." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0004507 +xref: FMA:12846 +xref: galen:CoronaryVein +xref: NCIT:C12878 +xref: NCIT:C12882 +xref: SCTID:277726009 +xref: Wikipedia:Coronary_circulation +xref: ZFA:0005814 is_a: UBERON:0003498 ! heart blood vessel is_a: UBERON:0005194 ! thoracic vein is_a: UBERON:0013140 ! systemic vein @@ -37894,6 +56552,10 @@ relationship: RO:0002179 UBERON:0002349 ! myocardium [Term] id: UBERON:0004151 name: cardiac chamber +def: "A cardiac chamber surrounds an enclosed cavity within the heart." [GO:0003205] +comment: generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus +xref: FMA:7095 +xref: SCTID:276456008 is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000948 ! part of heart @@ -37901,6 +56563,9 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: UBERON:0004160 name: proepicardium +def: "An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium." [GO:0003342, http://en.wiktionary.org/wiki/proepicardium] +xref: EMAPA:36025 +xref: ZFA:0005808 is_a: UBERON:0003104 ! mesenchyme relationship: BFO:0000050 UBERON:0004161 ! part of septum transversum relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system @@ -37908,6 +56573,15 @@ relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system [Term] id: UBERON:0004161 name: septum transversum +def: "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]." [VHOG:0000019, Wikipedia:Septum_transversum] +xref: EHDAA2:0001829 +xref: EHDAA:736 +xref: EMAPA:16318 +xref: FMA:295593 +xref: NCIT:C34296 +xref: SCTID:308819008 +xref: VHOG:0000019 +xref: Wikipedia:Septum_transversum is_a: UBERON:0003104 ! mesenchyme relationship: BFO:0000050 UBERON:0002100 ! part of trunk relationship: RO:0001025 UBERON:0002323 ! coelemic cavity lumen @@ -37915,17 +56589,28 @@ relationship: RO:0001025 UBERON:0002323 ! coelemic cavity lumen [Term] id: UBERON:0004175 name: internal genitalia +def: "The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [GO:0035260] +comment: TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 +xref: FMA:45652 is_a: UBERON:0003133 ! reproductive organ -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004176 name: external genitalia +def: "The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [GO:0035261] +comment: TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 +xref: FMA:45643 +xref: SCTID:362207005 is_a: UBERON:0003133 ! reproductive organ [Term] id: UBERON:0004177 name: hemopoietic organ +def: "Organ that is part of the hematopoietic system." [GOC:Obol] +xref: BTO:0004605 +xref: FMA:7143 +xref: MA:0000747 +xref: SCTID:361338006 is_a: UBERON:0000062 ! organ is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000062 ! organ @@ -37935,6 +56620,13 @@ relationship: BFO:0000050 UBERON:0002390 ! part of hematopoietic system [Term] id: UBERON:0004178 name: aorta smooth muscle tissue +def: "The nonstriated, involuntary muscle tissue located in the wall of the aorta." [MGI:csmith, MP:0009865] +xref: BTO:0001685 +xref: CALOHA:TS-0048 +xref: EFO:0002775 +xref: EMAPA:35135 +xref: MA:0000702 +xref: NCIT:C49191 is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -37944,6 +56636,8 @@ relationship: BFO:0000050 UBERON:0000947 ! part of aorta [Term] id: UBERON:0004185 name: endodermal part of digestive tract +def: "A portions of the gut that is derived from endoderm." [GO:0061031] +xref: EMAPA:32930 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract @@ -37953,14 +56647,48 @@ intersection_of: RO:0002202 UBERON:0000925 ! endoderm [Term] id: UBERON:0004215 name: back nerve +def: "A nerve that is part of a back [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000497 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum relationship: BFO:0000050 UBERON:0001137 ! part of dorsum +[Term] +id: UBERON:0004220 +name: large intestine smooth muscle +def: "A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35469 +xref: MA:0001547 +is_a: UBERON:0004221 ! intestine smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine +relationship: RO:0002131 UBERON:0011198 ! overlaps muscle layer of large intestine + +[Term] +id: UBERON:0004221 +name: intestine smooth muscle +def: "A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000643 +xref: EMAPA:35441 +xref: EMAPA:35443 +xref: MA:0001539 +xref: NCIT:C49243 +is_a: UBERON:0004226 ! gastrointestinal system smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine +relationship: RO:0002131 UBERON:0012367 ! overlaps muscle layer of intestine +relationship: RO:0002433 UBERON:0000160 ! intestine + [Term] id: UBERON:0004222 name: stomach smooth muscle +def: "A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001818 +xref: EMAPA:35823 +xref: MA:0001627 is_a: UBERON:0004226 ! gastrointestinal system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach @@ -37969,6 +56697,10 @@ relationship: BFO:0000050 UBERON:0001167 ! part of wall of stomach [Term] id: UBERON:0004225 name: respiratory system smooth muscle +def: "A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0001660 +xref: EMAPA:35734 +xref: MA:0001830 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -37977,14 +56709,30 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0004226 name: gastrointestinal system smooth muscle +def: "A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35117 +xref: MA:0001523 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system +[Term] +id: UBERON:0004231 +name: anal region smooth muscle +def: "A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001532 +is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region +relationship: BFO:0000050 UBERON:0001353 ! part of anal region + [Term] id: UBERON:0004233 name: lower respiratory tract smooth muscle +def: "A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35520 +xref: MA:0002410 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0004225 ! respiratory system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -37994,6 +56742,11 @@ relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract [Term] id: UBERON:0004234 name: iris smooth muscle +def: "A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000655 +xref: EMAPA:35448 +xref: FMA:312338 +xref: MA:0001270 is_a: UBERON:0003386 ! smooth muscle of eye intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001769 ! part of iris @@ -38002,6 +56755,10 @@ relationship: BFO:0000050 UBERON:0001606 ! part of muscle of iris [Term] id: UBERON:0004236 name: arteriole smooth muscle +def: "A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36287 +xref: FMA:312251 +xref: MA:0000706 is_a: UBERON:0004237 ! blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -38011,25 +56768,76 @@ relationship: BFO:0000050 UBERON:0001980 ! part of arteriole [Term] id: UBERON:0004237 name: blood vessel smooth muscle +def: "Smooth muscle found within, and composing the majority of the wall of blood vessels." [Wikipedia:Vascular_smooth_muscle] +xref: BTO:0001431 +xref: CALOHA:TS-1107 +xref: EMAPA:35177 +xref: MA:0000710 +xref: MESH:D009131 +xref: NCIT:C33853 +xref: TAO:0005321 +xref: Wikipedia:Vascular_smooth_muscle +xref: ZFA:0005321 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004238 +name: spleen smooth muscle +def: "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35807 +xref: MA:0000757 +is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + +[Term] +id: UBERON:0004239 +name: small intestine smooth muscle +def: "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35783 +xref: MA:0001559 +is_a: UBERON:0004221 ! intestine smooth muscle +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine +relationship: RO:0002131 UBERON:0011201 ! overlaps muscle layer of small intestine + +[Term] +id: UBERON:0004240 +name: gallbladder smooth muscle +def: "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35373 +xref: MA:0001635 +xref: NCIT:C49483 +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder [Term] id: UBERON:0004242 name: bronchus smooth muscle +def: "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004401 +xref: EMAPA:35195 +xref: MA:0001840 +xref: NCIT:C49213 is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: BFO:0000051 CL:0002598 ! has part bronchial smooth muscle cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004246 name: outflow tract smooth muscle +def: "A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000492 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract @@ -38038,6 +56846,8 @@ relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract [Term] id: UBERON:0004247 name: bone of dorsum +def: "A bone that is part of the dorsal region of an animal." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000494 is_a: UBERON:0001474 ! bone element is_a: UBERON:0005174 ! dorsal region element intersection_of: UBERON:0001474 ! bone element @@ -38046,6 +56856,11 @@ intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0004253 name: skin muscle +def: "Any muscle organ that is part of a skin of body [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18187 +xref: EMAPA:35776 +xref: MA:0002710 +xref: MA:0003139 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system @@ -38055,6 +56870,8 @@ relationship: RO:0001025 UBERON:0002097 ! skin of body [Term] id: UBERON:0004258 name: back blood vessel +def: "A blood vessel that is part of a back [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000493 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum @@ -38063,6 +56880,11 @@ relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0004265 name: outflow tract myocardium +def: "A myocardium that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001358 +xref: EMAPA:35623 +xref: MA:0000489 +xref: VHOG:0000603 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract @@ -38071,6 +56893,8 @@ relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract [Term] id: UBERON:0004267 name: back connective tissue +def: "A portion of connective tissue that is part of a back [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000495 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum @@ -38079,6 +56903,8 @@ relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0004271 name: outflow tract pericardium +def: "A pericardium that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000491 is_a: UBERON:0002407 ! pericardium is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0002407 ! pericardium @@ -38088,6 +56914,10 @@ relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract [Term] id: UBERON:0004277 name: eye muscle +def: "A muscle that is part of the eye region." [OBOL:automatic] +xref: AAO:0000156 +xref: EMAPA:35335 +xref: MA:0000271 is_a: UBERON:0001630 ! muscle organ is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001630 ! muscle organ @@ -38098,15 +56928,40 @@ relationship: RO:0002433 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0004288 name: skeleton +def: "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body." [VSAO:0000026] +xref: AEO:0000168 +xref: EHDAA2:0001843 +xref: EHDAA:5047 +xref: EMAPA:17213 +xref: FMA:23875 +xref: GAID:177 +xref: galen:Skeleton +xref: MA:0003006 +xref: MAT:0000032 +xref: MESH:D012863 +xref: MIAA:0000032 +xref: SCTID:361378004 +xref: VSAO:0000026 +xref: Wikipedia:Skeleton +xref: XAO:0004053 is_a: UBERON:0034925 ! anatomical collection disjoint_from: UBERON:0004770 ! articular system relationship: BFO:0000050 UBERON:0001434 ! part of skeletal system relationship: RO:0002351 UBERON:0004765 ! skeletal element -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004290 name: dermomyotome +def: "The bilaminar epithelium formed from the myotome and dermatome." [AEO:0000214] +xref: AAO:0010572 +xref: AEO:0000214 +xref: EHDAA2:0003259 +xref: EMAPA:31109 +xref: FMA:295654 +xref: NCIT:C34140 +xref: TAO:0001513 +xref: VHOG:0000676 +xref: ZFA:0001513 is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0016888 ! transitional anatomical structure relationship: BFO:0000051 CL:0000075 ! has part columnar/cuboidal epithelial cell @@ -38115,12 +56970,19 @@ relationship: RO:0002202 UBERON:0002329 ! somite [Term] id: UBERON:0004291 name: heart rudiment +def: "A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GO:0003313] +xref: TAO:0000115 +xref: ZFA:0000115 is_a: UBERON:0012275 ! meso-epithelium relationship: RO:0002202 UBERON:0004139 ! cardiogenic plate [Term] id: UBERON:0004292 name: cardiac skeleton +def: "Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart." [GO:0003204, Wikipedia:Cardiac_skeleton] +xref: EMAPA:36645 +xref: FMA:9496 +xref: Wikipedia:Cardiac_skeleton is_a: UBERON:0003837 ! thoracic segment connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000948 ! part of heart @@ -38130,6 +56992,8 @@ relationship: RO:0002220 UBERON:0002082 ! adjacent to cardiac ventricle [Term] id: UBERON:0004297 name: respiratory system blood vessel smooth muscle +def: "A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001806 is_a: UBERON:0004225 ! respiratory system smooth muscle is_a: UBERON:0004237 ! blood vessel smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue @@ -38139,6 +57003,12 @@ relationship: BFO:0000050 UBERON:0003504 ! part of respiratory system blood vess [Term] id: UBERON:0004345 name: trophectoderm +def: "Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition." [MP:0005028] +xref: BTO:0001840 +xref: EHDAA2:0002091 +xref: EHDAA:56 +xref: EMAPA:16046 +xref: VHOG:0000979 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005292 ! extraembryonic tissue relationship: BFO:0000050 UBERON:0005631 ! part of extraembryonic membrane @@ -38148,12 +57018,25 @@ relationship: RO:0002202 UBERON:0000085 ! morula [Term] id: UBERON:0004348 name: optic eminence +def: "The embryonic structure that gives rise to the corneal ectoderm." [MP:0006305] +xref: EHDAA:938 +xref: EMAPA:16322 +xref: RETIRED_EHDAA2:0001308 +xref: VHOG:0001296 is_a: UBERON:0006598 ! presumptive structure relationship: RO:0002387 UBERON:0000964 ! cornea [Term] id: UBERON:0004356 name: apical ectodermal ridge +def: "Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]." [MP:0001676, Wikipedia:Apical_ectodermal_ridge] +xref: AAO:0010760 +xref: EMAPA:32744 +xref: NCIT:C34109 +xref: TAO:0002146 +xref: Wikipedia:Apical_ectodermal_ridge +xref: XAO:0004121 +xref: ZFA:0001702 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm relationship: BFO:0000050 UBERON:0004357 ! part of paired limb/fin bud @@ -38165,6 +57048,9 @@ relationship: RO:0003000 PR:000007499 ! produces [Term] id: UBERON:0004357 name: paired limb/fin bud +def: "An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]." [https://orcid.org/0000-0002-6601-2165, ISBN:9780878932504, MP:0005650] +comment: Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056] +xref: VHOG:0001258 is_a: UBERON:0003102 ! surface structure is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000051 UBERON:0004356 ! has part apical ectodermal ridge @@ -38174,11 +57060,39 @@ relationship: RO:0002387 UBERON:0004708 ! paired limb/fin [Term] id: UBERON:0004362 name: pharyngeal arch 1 +def: "The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0010364 +xref: CALOHA:TS-2089 +xref: EHDAA2:0000006 +xref: EHDAA:573 +xref: EMAPA:16118 +xref: FMA:293019 +xref: MFMO:0000095 +xref: NCIT:C34175 +xref: SCTID:308767008 +xref: TAO:0001595 +xref: VHOG:0000296 +xref: Wikipedia:First_pharyngeal_arch +xref: XAO:0000097 +xref: ZFA:0001612 is_a: UBERON:0002539 ! pharyngeal arch [Term] id: UBERON:0004363 name: pharyngeal arch artery +def: "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]." [MP:0002672] +xref: AAO:0010414 +xref: EFO:0003695 +xref: EHDAA2:0000186 +xref: EHDAA:398 +xref: EHDAA:7327 +xref: EMAPA:16684 +xref: NCIT:C32123 +xref: TAO:0005004 +xref: VHOG:0000122 +xref: Wikipedia:Aortic_arches +xref: XAO:0000341 +xref: ZFA:0005004 is_a: UBERON:0003469 ! respiratory system artery is_a: UBERON:0003496 ! head blood vessel is_a: UBERON:0006598 ! presumptive structure @@ -38191,12 +57105,17 @@ relationship: RO:0002433 UBERON:0002539 ! pharyngeal arch [Term] id: UBERON:0004364 name: ectoplacental cone +def: "Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta." [MP:0001717, PMID:19829370] +xref: BTO:0001715 +xref: EMAPA:16059 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000088 ! part of trophoblast [Term] id: UBERON:0004365 name: vitelline blood vessel +def: "Blood vessel that is connected to the yolk sac." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:36494 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: RO:0002170 UBERON:0001040 ! yolk sac @@ -38206,6 +57125,18 @@ relationship: RO:0002170 UBERON:0001040 ! yolk sac [Term] id: UBERON:0004367 name: Descemet's membrane +def: "A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]." [https://github.com/obophenotype/uberon/issues/15, MP:0004285] +comment: The strong, resistant, thin, noncellular fourth layer of the cornea, located between the endothelium (from which it is secreted) and the stroma. (Cline et al., Dictionary of Visual Science, 4th ed) +xref: EMAPA:18804 +xref: FMA:58309 +xref: GAID:894 +xref: MA:0001246 +xref: MESH:D003886 +xref: NCIT:C32454 +xref: SCTID:281076002 +xref: TAO:0002157 +xref: Wikipedia:Descemet%27s_membrane +xref: ZFA:0001686 is_a: UBERON:0005769 ! basement membrane of epithelium is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0005769 ! basement membrane of epithelium @@ -38221,6 +57152,14 @@ relationship: RO:0003001 UBERON:0001985 ! produced by corneal endothelium [Term] id: UBERON:0004370 name: anterior limiting lamina of cornea +def: "A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane." [ncithesaurus:Bowman_s_Membrane] +xref: FMA:58273 +xref: MA:0001240 +xref: NCIT:C32226 +xref: SCTID:281075003 +xref: TAO:0002155 +xref: Wikipedia:Bowman%27s_membrane +xref: ZFA:0001684 is_a: UBERON:0005769 ! basement membrane of epithelium is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0005769 ! basement membrane of epithelium @@ -38232,6 +57171,8 @@ relationship: RO:0002371 UBERON:0001772 ! corneal epithelium [Term] id: UBERON:0004374 name: vitelline vasculature +def: "Vascular network that is connected to the yolk sac." [http://orcid.org/0000-0002-6601-2165] +xref: Wikipedia:Vitelline_circulation is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: RO:0002170 UBERON:0001040 ! yolk sac @@ -38240,15 +57181,33 @@ relationship: RO:0002170 UBERON:0001040 ! yolk sac [Term] id: UBERON:0004375 name: bone of free limb or fin +def: "A bone that is part of an appendage [Automatically generated definition]." [OBOL:automatic] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010740 ! bone of appendage girdle complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0004708 ! part of paired limb/fin relationship: BFO:0000050 UBERON:0011582 ! part of paired limb/fin skeleton +[Term] +id: UBERON:0004451 +name: trunk or cervical vertebra +def: "A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra." [UBERONREF:0000006] +xref: MA:0002869 +xref: XAO:0003077 +is_a: UBERON:0002412 ! vertebra +intersection_of: UBERON:0002412 ! vertebra +intersection_of: BSPO:0000096 UBERON:0001095 ! caudal vertebra +union_of: UBERON:0002413 ! cervical vertebra +union_of: UBERON:0011677 ! trunk vertebra +relationship: BSPO:0000096 UBERON:0001095 ! caudal vertebra + [Term] id: UBERON:0004455 name: neurula embryo +def: "An embryo at the neurula stage." [http://orcid.org/0000-0002-6601-2165] +xref: BILA:0000061 +xref: BTO:0001766 +xref: NCIT:C34229 is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002491 UBERON:0000110 ! neurula stage @@ -38258,6 +57217,8 @@ relationship: RO:0002491 UBERON:0000110 ! neurula stage [Term] id: UBERON:0004456 name: entire sense organ system +def: "Sum of all sensory systems in an organism." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:78499 is_a: UBERON:0000467 ! anatomical system disjoint_from: UBERON:8450002 ! excretory system relationship: RO:0002131 UBERON:0001016 ! overlaps nervous system @@ -38266,6 +57227,10 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0004461 name: skeletal musculature of head +def: "Any collection of skeletal muscles that is part of a head [Automatically generated definition]." [OBOL:automatic] +comment: This class is restricted to skeletal muscles that attach to the cranial skeleton. This seems to be consistent with FMA and EMAPA usage. Note that by definition this excludes invertebrate head musculature. It corresponds to the individual muscle organ term UBERON:0002376 +xref: EMAPA:18171 +xref: FMA:71287 is_a: UBERON:0008229 ! craniocervical region musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -38278,6 +57243,9 @@ relationship: RO:0002371 UBERON:0003129 ! skull [Term] id: UBERON:0004464 name: musculature of thorax +def: "Any collection of muscles that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0000508 +xref: FMA:71293 is_a: UBERON:0004479 ! musculature of trunk intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -38286,14 +57254,30 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0004465 name: musculature of neck +def: "Any collection of muscles that is part of a neck [Automatically generated definition]." [OBOL:automatic] +xref: AAO:0000091 +xref: EMAPA:36050 +xref: FMA:71290 +xref: MESH:D009334 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000974 ! part of neck relationship: BFO:0000050 UBERON:0000974 ! part of neck +[Term] +id: UBERON:0004468 +name: set of muscles of vertebral column +xref: FMA:33061 +is_a: UBERON:0001015 ! musculature +intersection_of: UBERON:0001015 ! musculature +intersection_of: RO:0002371 UBERON:0001130 ! vertebral column +relationship: RO:0002371 UBERON:0001130 ! vertebral column + [Term] id: UBERON:0004469 name: musculature of back +def: "Any collection of muscles that is part of a back [Automatically generated definition]." [OBOL:automatic] +xref: FMA:71291 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum @@ -38302,6 +57286,9 @@ relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0004471 name: musculature of pectoral girdle +def: "A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0000423 +xref: FMA:33519 is_a: UBERON:0014793 ! musculature of pectoral complex intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region @@ -38310,6 +57297,8 @@ relationship: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region [Term] id: UBERON:0004473 name: musculature of face +def: "Any collection of muscles that is part of a face." [OBOL:automatic] +xref: FMA:71288 is_a: UBERON:0008229 ! craniocervical region musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0001456 ! part of face @@ -38318,6 +57307,10 @@ relationship: BFO:0000050 UBERON:0001456 ! part of face [Term] id: UBERON:0004479 name: musculature of trunk +def: "Any collection of muscles that is part of a trunk [Automatically generated definition]." [OBOL:automatic] +xref: AAO:0011572 +xref: EFO:0003531 +xref: FMA:50187 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -38326,6 +57319,8 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0004490 name: cardiac muscle tissue of atrium +def: "A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]." [OBOL:automatic] +xref: FMA:7283 is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium @@ -38334,6 +57329,8 @@ relationship: BFO:0000050 UBERON:0002302 ! part of myocardium of atrium [Term] id: UBERON:0004491 name: cardiac muscle tissue of interatrial septum +def: "A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]." [OBOL:automatic] +xref: FMA:84083 is_a: UBERON:0004492 ! cardiac muscle tissue of cardiac septum intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002085 ! part of interatrial septum @@ -38342,6 +57339,8 @@ relationship: BFO:0000050 UBERON:0002085 ! part of interatrial septum [Term] id: UBERON:0004492 name: cardiac muscle tissue of cardiac septum +def: "A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]." [OBOL:automatic] +xref: FMA:226279 is_a: UBERON:0001133 ! cardiac muscle tissue intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002099 ! part of cardiac septum @@ -38350,6 +57349,9 @@ relationship: BFO:0000050 UBERON:0002099 ! part of cardiac septum [Term] id: UBERON:0004493 name: cardiac muscle tissue of myocardium +def: "A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]." [OBOL:automatic] +xref: FMA:261726 +xref: MA:0002441 is_a: UBERON:0001133 ! cardiac muscle tissue intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002349 ! part of myocardium @@ -38358,6 +57360,8 @@ relationship: BFO:0000050 UBERON:0002349 ! part of myocardium [Term] id: UBERON:0004495 name: skeletal muscle tissue of diaphragm +def: "A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition]." [OBOL:automatic] +xref: FMA:261898 is_a: UBERON:0003898 ! skeletal muscle tissue of trunk is_a: UBERON:0004830 ! respiratory system skeletal muscle intersection_of: UBERON:0001134 ! skeletal muscle tissue @@ -38367,35 +57371,50 @@ relationship: BFO:0000050 UBERON:0001103 ! part of diaphragm [Term] id: UBERON:0004515 name: smooth muscle tissue of bronchiole +def: "A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:261045 is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002186 ! part of bronchiole relationship: BFO:0000050 UBERON:0002186 ! part of bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004516 name: smooth muscle tissue of terminal bronchiole +def: "A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:261051 is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole relationship: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole relationship: BFO:0000051 CL:4033017 ! has part bronchiolar smooth muscle cell -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004517 name: smooth muscle tissue of respiratory bronchiole +def: "A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:261055 is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole relationship: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole relationship: BFO:0000051 CL:4033017 ! has part bronchiolar smooth muscle cell -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004518 +name: muscle of vertebral column +def: "A muscle that is attached to a vertebra of the vertebral column." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:22594 +is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate +intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate +intersection_of: RO:0002371 UBERON:0002412 ! vertebra +relationship: RO:0002371 UBERON:0002412 ! vertebra [Term] id: UBERON:0004521 name: vasculature of muscle organ +def: "A vasculature that is part of a muscle organ [Automatically generated definition]." [OBOL:automatic] +xref: FMA:87123 is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001630 ! part of muscle organ @@ -38404,14 +57423,61 @@ relationship: BFO:0000050 UBERON:0001630 ! part of muscle organ [Term] id: UBERON:0004522 name: vasculature of musculoskeletal system +def: "A vasculature that is part of a musculoskeletal system [Automatically generated definition]." [OBOL:automatic] +xref: FMA:239607 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0002204 ! part of musculoskeletal system relationship: BFO:0000050 UBERON:0002204 ! part of musculoskeletal system +[Term] +id: UBERON:0004525 +name: cardiac muscle tissue of trabecula carnea of right ventricle +def: "A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]." [OBOL:automatic] +xref: FMA:84429 +is_a: UBERON:0003381 ! cardiac muscle of right ventricle +is_a: UBERON:0003452 ! trabecula carnea cardiac muscle tissue +intersection_of: UBERON:0003452 ! trabecula carnea cardiac muscle tissue +intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle +relationship: BFO:0000050 UBERON:0006570 ! part of trabecula carnea of right ventricle + +[Term] +id: UBERON:0004526 +name: cardiac muscle tissue of trabecula carnea of left ventricle +def: "A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]." [OBOL:automatic] +xref: FMA:84430 +is_a: UBERON:0003382 ! cardiac muscle of left ventricle +is_a: UBERON:0003452 ! trabecula carnea cardiac muscle tissue +intersection_of: UBERON:0003452 ! trabecula carnea cardiac muscle tissue +intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle +relationship: BFO:0000050 UBERON:0006571 ! part of trabecula carnea of left ventricle + [Term] id: UBERON:0004535 name: cardiovascular system +def: "Anatomical system that has as its parts the heart and blood vessels." [BTO:0000088] +xref: AAO:0011001 +xref: BILA:0000016 +xref: BTO:0000088 +xref: CALOHA:TS-1297 +xref: EFO:0000791 +xref: EHDAA:394 +xref: EMAPA:16104 +xref: EV:0100017 +xref: FMA:7161 +xref: GAID:467 +xref: MA:0000010 +xref: MAT:0000016 +xref: MESH:D002319 +xref: MIAA:0000016 +xref: NCIT:C12686 +xref: SCTID:278198007 +xref: TAO:0000010 +xref: VHOG:0000302 +xref: WikipediaCategory:Cardiovascular_system +xref: XAO:0000100 +xref: XAO:0001010 +xref: ZFA:0000010 is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: BFO:0000050 UBERON:0001009 ! part of circulatory system @@ -38420,20 +57486,26 @@ intersection_of: BFO:0000051 UBERON:0001981 ! has part blood vessel relationship: BFO:0000050 UBERON:0001009 ! part of circulatory system relationship: BFO:0000051 UBERON:0000948 ! has part heart relationship: BFO:0000051 UBERON:0001981 ! has part blood vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004537 name: blood vasculature +def: "A vascular network consisting of blood vessels." [https://orcid.org/0000-0002-6601-2165] +xref: TAO:0001079 +xref: ZFA:0001079 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: RO:0002473 UBERON:0001981 ! blood vessel relationship: RO:0002473 UBERON:0001981 ! blood vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004548 name: left eye +def: "An eye that is part of a left side of organism [Automatically generated definition]." [OBOL:automatic] +xref: FMA:12515 +xref: MA:0002949 +xref: NCIT:C119334 +xref: SCTID:362503005 is_a: UBERON:0000970 ! eye is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000970 ! eye @@ -38443,6 +57515,11 @@ relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0004549 name: right eye +def: "An eye that is part of a right side of organism [Automatically generated definition]." [OBOL:automatic] +xref: FMA:12514 +xref: MA:0002950 +xref: NCIT:C119333 +xref: SCTID:362502000 is_a: UBERON:0000970 ! eye is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0000970 ! eye @@ -38452,50 +57529,110 @@ relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0004571 name: systemic arterial system +def: "The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Systemic_circulation#Arteries] +xref: FMA:45623 +xref: Wikipedia:Systemic_circulation#Arteries is_a: UBERON:0007798 ! vascular system relationship: BFO:0000050 UBERON:0004572 ! part of arterial system [Term] id: UBERON:0004572 name: arterial system +def: "The part of the cardiovascular system consisting of all arteries." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0004690 +xref: EHDAA2:0000143 +xref: EHDAA:396 +xref: EMAPA:16201 +xref: EMAPA:16371 +xref: MA:0002719 +xref: SCTID:362030008 +xref: VHOG:0000273 is_a: UBERON:0007798 ! vascular system relationship: RO:0002351 UBERON:0001637 ! artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004573 name: systemic artery +def: "An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Artery#Systemic_arteries] +xref: FMA:66464 +xref: Wikipedia:Artery#Systemic_arteries is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: BFO:0000050 UBERON:0004571 ! part of systemic arterial system relationship: BFO:0000050 UBERON:0004571 ! part of systemic arterial system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004581 name: systemic venous system +def: "The part of the venous system that drains the general body tissues[Kardong]." [ISBN:0073040584, Wikipedia:Systemic_venous_system] +xref: FMA:45626 +xref: Wikipedia:Systemic_venous_system is_a: UBERON:0002049 ! vasculature relationship: BFO:0000050 UBERON:0004582 ! part of venous system [Term] id: UBERON:0004582 name: venous system +def: "The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0004692 +xref: EHDAA2:0002171 +xref: EHDAA:486 +xref: EMAPA:16240 +xref: MA:0002720 +xref: NCIT:C33858 +xref: SCTID:362060003 +xref: VHOG:0000277 is_a: UBERON:0007798 ! vascular system relationship: RO:0002473 UBERON:0001638 ! vein -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004590 +name: sphincter muscle +def: "A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [Wikipedia:Sphincter] +xref: FMA:75004 +xref: NCIT:C28381 +xref: Wikipedia:Sphincter +is_a: UBERON:0001630 ! muscle organ [Term] id: UBERON:0004638 name: blood vessel endothelium +def: "An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0000766 +xref: CALOHA:TS-2155 +xref: EMAPA:35176 +xref: MA:0000709 +xref: NCIT:C53395 +xref: TAO:0005257 +xref: ZFA:0005257 is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004647 +name: liver lobule +def: "The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein." [ISBN:0-683-40008-8, MP:0008987] +xref: EMAPA:35499 +xref: FMA:14471 +xref: MA:0002494 +xref: NCIT:C32732 +xref: SCTID:362194004 +xref: Wikipedia:Lobules_of_liver +is_a: UBERON:0000064 ! organ part +is_a: UBERON:0004119 ! endoderm-derived structure +relationship: BFO:0000050 UBERON:0001280 ! part of liver parenchyma +relationship: BFO:0000051 CL:0000182 ! has part hepatocyte +relationship: RO:0002433 UBERON:0001280 ! liver parenchyma [Term] id: UBERON:0004663 name: aorta wall +def: "An anatomical wall that is part of an aorta, enclosing the luminal space." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:35139 +xref: FMA:14156 +xref: MA:0002901 is_a: UBERON:0035965 ! wall of blood vessel intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta @@ -38505,6 +57642,11 @@ relationship: RO:0002433 UBERON:0000947 ! aorta [Term] id: UBERON:0004664 name: aorta tunica adventitia +def: "The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers." [ISBN:0-683-40008-8, MP:0009871] +xref: EMAPA:35136 +xref: FMA:14283 +xref: MA:0002902 +xref: SCTID:24996002 is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta @@ -38514,6 +57656,13 @@ relationship: RO:0002433 UBERON:0004663 ! aorta wall [Term] id: UBERON:0004666 name: interventricular septum membranous part +def: "The membranous portion of the wall between the two lower chambers of the heart." [MP:0008823] +xref: EHDAA2:0004596 +xref: EMAPA:18246 +xref: FMA:7135 +xref: MA:0002939 +xref: SCTID:278228007 +xref: VHOG:0000927 is_a: UBERON:0000158 ! membranous layer is_a: UBERON:0005983 ! heart layer is_a: UBERON:0010313 ! neural crest-derived structure @@ -38526,6 +57675,13 @@ relationship: RO:0002433 UBERON:0002094 ! interventricular septum [Term] id: UBERON:0004667 name: interventricular septum muscular part +def: "The muscular portion of the wall between the two lower chambers of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Interventricular_septum#Portions] +xref: EHDAA2:0000885 +xref: EHDAA:2607 +xref: EMAPA:18247 +xref: FMA:7134 +xref: MA:0002940 +xref: RETIRED_EHDAA2:0000888 is_a: UBERON:0002385 ! muscle tissue intersection_of: UBERON:0002385 ! muscle tissue intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum @@ -38535,6 +57691,19 @@ relationship: RO:0002433 UBERON:0002094 ! interventricular septum [Term] id: UBERON:0004684 name: raphe nuclei +def: "The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane." [https://sourceforge.net/tracker/?func=detail&aid=3248146&group_id=36855&atid=440764, NLXANAT:20090205] +comment: we treat NR obscurus, NR magnus etc as parts of the raphe nuclei. This is consistent with treatment in FMA, where the class is 'set of raphe nuclei' +xref: BAMS:RA +xref: EMAPA:35721 +xref: FMA:84017 +xref: MA:0003147 +xref: MESH:D011903 +xref: NCIT:C97335 +xref: neuronames:2495 +xref: NLXANAT:20090205 +xref: TAO:0001429 +xref: Wikipedia:Raphe_nuclei +xref: ZFA:0001429 is_a: UBERON:0002616 ! regional part of brain relationship: BFO:0000050 UBERON:0002275 ! part of reticular formation relationship: RO:0002215 GO:0001820 ! capable of serotonin secretion @@ -38542,13 +57711,20 @@ relationship: RO:0002215 GO:0001820 ! capable of serotonin secretion [Term] id: UBERON:0004688 name: costo-cervical trunk +def: "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]." [Wikipedia:Costocervical_trunk] +xref: FMA:10636 +xref: MA:0001939 +xref: SCTID:244225009 +xref: Wikipedia:Costocervical_trunk is_a: UBERON:0001637 ! artery relationship: RO:0002170 UBERON:0001533 ! subclavian artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004695 name: arterial system smooth muscle +def: "A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36503 +xref: MA:0000704 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0004572 ! part of arterial system @@ -38557,6 +57733,9 @@ relationship: BFO:0000050 UBERON:0004572 ! part of arterial system [Term] id: UBERON:0004696 name: venous system smooth muscle +def: "A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36613 +xref: MA:0000715 is_a: UBERON:0004237 ! blood vessel smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0004582 ! part of venous system @@ -38566,6 +57745,9 @@ relationship: BFO:0000050 UBERON:0004582 ! part of venous system [Term] id: UBERON:0004698 name: vena cava endothelium +def: "An endothelium that is part of a vena cava [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000713 +xref: NCIT:C49318 is_a: UBERON:0001919 ! endothelium of vein intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004087 ! part of vena cava @@ -38574,6 +57756,9 @@ relationship: BFO:0000050 UBERON:0004087 ! part of vena cava [Term] id: UBERON:0004699 name: outflow tract endothelium +def: "An endothelium that is part of a outflow tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0000490 +xref: VHOG:0001524 is_a: UBERON:0008307 ! heart endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004145 ! part of outflow tract @@ -38582,6 +57767,10 @@ relationship: BFO:0000050 UBERON:0004145 ! part of outflow tract [Term] id: UBERON:0004700 name: arterial system endothelium +def: "An endothelium that is part of an arterial system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35145 +xref: MA:0000703 +xref: NCIT:C49329 is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004572 ! part of arterial system @@ -38590,6 +57779,10 @@ relationship: BFO:0000050 UBERON:0004572 ! part of arterial system [Term] id: UBERON:0004701 name: venous system endothelium +def: "An endothelium that is part of a venous system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35907 +xref: MA:0000714 +xref: NCIT:C49320 is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004582 ! part of venous system @@ -38598,6 +57791,9 @@ relationship: BFO:0000050 UBERON:0004582 ! part of venous system [Term] id: UBERON:0004702 name: respiratory system blood vessel endothelium +def: "A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35732 +xref: MA:0001805 is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004807 ! respiratory system epithelium intersection_of: UBERON:0004638 ! blood vessel endothelium @@ -38607,12 +57803,23 @@ relationship: BFO:0000050 UBERON:0003504 ! part of respiratory system blood vess [Term] id: UBERON:0004706 name: bulbus cordis +def: "A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches." [ISBN:0-683-40008-8, MP:0010568] +xref: EHDAA2:0000197 +xref: EHDAA:438 +xref: EHDAA:768 +xref: EMAPA:16333 +xref: FMA:70300 +xref: NCIT:C34114 +xref: SCTID:361525002 +xref: Wikipedia:Bulbus_cordis is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: UBERON:0004708 name: paired limb/fin +def: "An appendage that is part of an appendage girdle complex." [https://github.com/geneontology/go-ontology/issues/9029, UBERON:cjm] +xref: VSAO:0000067 is_a: UBERON:0000026 ! appendage intersection_of: UBERON:0000026 ! appendage intersection_of: BFO:0000050 UBERON:0010707 ! part of appendage girdle complex @@ -38628,6 +57835,9 @@ relationship: RO:0002551 UBERON:0011582 ! paired limb/fin skeleton [Term] id: UBERON:0004710 name: pectoral appendage +def: "Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues." [VSAO:0000150-modified] +xref: VHOG:0001753 +xref: VSAO:0000125 is_a: UBERON:0004708 ! paired limb/fin intersection_of: UBERON:0004708 ! paired limb/fin intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex @@ -38639,6 +57849,16 @@ relationship: RO:0002551 UBERON:0007272 ! pectoral appendage skeleton [Term] id: UBERON:0004711 name: jugular vein +def: "The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava." [Wikipedia:Jugular_vein] +xref: BTO:0001744 +xref: CALOHA:TS-0497 +xref: EMAPA:18638 +xref: GAID:536 +xref: MA:0002154 +xref: MESH:D007601 +xref: NCIT:C12738 +xref: SCTID:244403000 +xref: Wikipedia:Jugular_vein is_a: UBERON:0001638 ! vein relationship: BFO:0000050 UBERON:0000974 {gci_filler="NCBITaxon:8287", gci_relation="RO:0002162"} ! part of neck relationship: RO:0002179 UBERON:0000033 ! head @@ -38646,6 +57866,14 @@ relationship: RO:0002179 UBERON:0000033 ! head [Term] id: UBERON:0004716 name: conceptus +def: "The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]." [BTO:0003834, Wikipedia:Conceptus] +xref: AEO:0000194 +xref: BTO:0003834 +xref: EHDAA2:0000001 +xref: EHDAA2:0003235 +xref: EMAPA:36040 +xref: NCIT:C34131 +xref: Wikipedia:Conceptus is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000051 UBERON:0002050 ! has part embryonic structure relationship: BFO:0000051 UBERON:0016887 ! has part entire extraembryonic component @@ -38656,6 +57884,11 @@ relationship: RO:0002493 UBERON:0000068 ! embryo stage [Term] id: UBERON:0004731 name: neuromere +def: "A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres)." [DOI:10.1016/j.tins.2013.06.004, https://github.com/obophenotype/uberon/issues/318] +xref: NLX:147842 +xref: TAO:0001328 +xref: Wikipedia:Neuromere +xref: ZFA:0001328 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: UBERON:0004732 ! segmental subdivision of nervous system @@ -38665,6 +57898,7 @@ relationship: BFO:0000050 UBERON:0001049 ! part of neural tube [Term] id: UBERON:0004732 name: segmental subdivision of nervous system +def: "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres." [FBbt:00005140, http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000063 ! organ subunit intersection_of: UBERON:0000063 ! organ subunit intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system @@ -38673,6 +57907,8 @@ relationship: BFO:0000050 UBERON:0001016 ! part of nervous system [Term] id: UBERON:0004733 name: segmental subdivision of hindbrain +def: "An organ subunit that is part of a hindbrain [Automatically generated definition]." [OBOL:automatic] +xref: FMA:61998 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004732 ! segmental subdivision of nervous system intersection_of: UBERON:0000063 ! organ subunit @@ -38682,6 +57918,17 @@ relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain [Term] id: UBERON:0004734 name: gastrula +def: "Organism at the gastrula stage." [Wikipedia:Gastrula, Wikipedia:Trilaminar_blastocyst] +xref: BILA:0000060 +xref: BTO:0001403 +xref: FMA:293108 +xref: GAID:1302 +xref: MESH:D005775 +xref: MIAA:0000179 +xref: NCIT:C34057 +xref: NCIT:C34058 +xref: Wikipedia:Gastrula +xref: Wikipedia:Trilaminar_blastocyst is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002491 UBERON:0000109 ! gastrula stage @@ -38691,6 +57938,13 @@ relationship: RO:0002491 UBERON:0000109 ! gastrula stage [Term] id: UBERON:0004755 name: skeletal tissue +def: "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/134, PSPUB:0000170, VSAO:0000015] +comment: Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from +xref: MA:0003047 +xref: SCTID:309311006 +xref: VSAO:0000015 +xref: XAO:0004038 +xref: ZFA:0005619 is_a: UBERON:0002384 ! connective tissue relationship: BFO:0000050 UBERON:0004765 ! part of skeletal element relationship: RO:0002202 CL:0007001 ! skeletogenic cell @@ -38698,6 +57952,7 @@ relationship: RO:0002202 CL:0007001 ! skeletogenic cell [Term] id: UBERON:0004756 name: dermal skeletal element +def: "Dermis-derived entity that is made of skeletal tissue." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/206] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004765 ! skeletal element intersection_of: UBERON:0004765 ! skeletal element @@ -38706,9 +57961,35 @@ intersection_of: RO:0002202 UBERON:0002067 ! dermis relationship: BFO:0000051 UBERON:0004755 ! has part skeletal tissue relationship: RO:0002202 UBERON:0002067 ! dermis +[Term] +id: UBERON:0004760 +name: gland of anal canal +def: "A gland that is part of an anal canal [Automatically generated definition]." [OBOL:automatic, Wikipedia:Anal_gland] +xref: EMAPA:27221 +xref: EMAPA:27233 +xref: EMAPA:27543 +xref: FMA:15720 +xref: FMA:15724 +xref: NCIT:C32068 +xref: SCTID:245448005 +xref: Wikipedia:Anal_gland +is_a: UBERON:0003408 ! gland of digestive tract +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0002530 ! gland +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal + [Term] id: UBERON:0004761 name: cartilaginous neurocranium +def: "The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]." [Wikipedia:Chondrocranium] +xref: AAO:0000094 +xref: EHDAA:6031 +xref: FMA:76621 +xref: NCIT:C34121 +xref: SCTID:155540009 +xref: Wikipedia:Chondrocranium +xref: XAO:0003059 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000051 UBERON:0002418 ! has part cartilage tissue relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -38717,6 +57998,9 @@ relationship: RO:0002202 UBERON:0009617 ! head paraxial mesoderm [Term] id: UBERON:0004764 name: intramembranous bone tissue +def: "Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]." [GO:0001957, Wikipedia:Intramembranous_ossification] +xref: MA:0002837 +xref: Wikipedia:Intramembranous_ossification is_a: UBERON:0002481 ! bone tissue intersection_of: UBERON:0002481 ! bone tissue intersection_of: RO:0002353 GO:0001957 ! output of intramembranous ossification @@ -38727,21 +58011,30 @@ relationship: RO:0002353 GO:0001957 ! output of intramembranous ossification [Term] id: UBERON:0004765 name: skeletal element +def: "Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0011129 +xref: galen:SkeletalStructure +xref: TAO:0001890 +xref: VSAO:0000128 +xref: XAO:0004012 +xref: ZFA:0005494 is_a: UBERON:0000062 ! organ relationship: BFO:0000050 UBERON:0001434 ! part of skeletal system [Term] id: UBERON:0004766 name: cranial bone +def: "A bone that is part of a cranium." [UBERON:automatic] +xref: SCTID:181792001 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0003128 ! part of cranium relationship: BFO:0000050 UBERON:0003128 ! part of cranium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004768 name: bone of lower jaw +def: "Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0012360 ! bone of jaw intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001710 ! part of lower jaw region @@ -38750,6 +58043,12 @@ relationship: BFO:0000050 UBERON:0003278 ! part of skeleton of lower jaw [Term] id: UBERON:0004770 name: articular system +def: "Anatomical system that consists of all the joints of the body." [VSAO:0000181] +xref: EMAPA:35150 +xref: FMA:23878 +xref: MA:0003007 +xref: SCTID:361827000 +xref: VSAO:0000181 is_a: UBERON:0034925 ! anatomical collection intersection_of: UBERON:0034925 ! anatomical collection intersection_of: RO:0002351 UBERON:0000982 ! skeletal joint @@ -38762,6 +58061,8 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0004777 name: respiratory system submucosa +def: "A submucosa that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001822 is_a: UBERON:0000009 ! submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -38770,6 +58071,8 @@ relationship: BFO:0000050 UBERON:0003570 ! part of respiratory system connective [Term] id: UBERON:0004779 name: respiratory system lamina propria +def: "A lamina propria that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001821 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -38779,22 +58082,59 @@ relationship: BFO:0000050 UBERON:0004785 ! part of respiratory system mucosa [Term] id: UBERON:0004780 name: gastrointestinal system lamina propria +def: "A lamina propria that is part of a gastrointestinal system." [OBOL:automatic] +xref: MA:0001899 +xref: NCIT:C49299 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0004786 ! part of gastrointestinal system mucosa +[Term] +id: UBERON:0004781 +name: gallbladder lamina propria +def: "A lamina propria that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35371 +xref: FMA:278594 +xref: MA:0001633 +xref: NCIT:C49228 +is_a: UBERON:0000030 ! lamina propria +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0005033 ! part of mucosa of gallbladder + [Term] id: UBERON:0004782 name: gastrointestinal system serosa +def: "A serous membrane that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001522 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system +[Term] +id: UBERON:0004783 +name: gallbladder serosa +def: "A serous membrane that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35372 +xref: FMA:14659 +xref: MA:0001634 +xref: SCTID:362197006 +is_a: UBERON:0000042 ! serous membrane +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder + [Term] id: UBERON:0004784 name: heart ventricle wall +def: "An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]." [OBOL:automatic] +xref: FMA:13884 +xref: MA:0002791 +xref: NCIT:C119295 is_a: UBERON:0037144 ! wall of heart intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -38803,6 +58143,12 @@ relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle [Term] id: UBERON:0004785 name: respiratory system mucosa +def: "The mucous membrane lining the respiratory tract." [MESH:A04.760, MGI:cwg, MP:0002277] +xref: BTO:0000973 +xref: FMA:302092 +xref: GAID:304 +xref: MA:0001827 +xref: MESH:D020545 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -38811,6 +58157,13 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0004786 name: gastrointestinal system mucosa +def: "A mucosa that is part of a gastrointestinal system." [OBOL:automatic] +comment: The gut mucosa of amphioxus has insulin-secreting cells. http://www.ncbi.nlm.nih.gov/pubmed/16417468 +xref: BTO:0000546 +xref: BTO:0005568 +xref: EMAPA:36591 +xref: MA:0001521 +xref: SCTID:410433007 is_a: UBERON:0000344 ! mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system @@ -38821,17 +58174,69 @@ relationship: BFO:0000051 CL:0000696 ! has part PP cell relationship: BFO:0000051 CL:0002067 ! has part type A enteroendocrine cell relationship: RO:0002220 UBERON:0006909 ! adjacent to lumen of digestive tract +[Term] +id: UBERON:0004790 +name: skin mucous gland +def: "A mucous gland that is part of the skin." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:35775 +xref: MA:0000148 +is_a: UBERON:0000414 ! mucous gland +is_a: UBERON:0007771 ! epidermis gland +is_a: UBERON:0019319 ! exocrine gland of integumental system +intersection_of: UBERON:0000414 ! mucous gland +intersection_of: BFO:0000050 UBERON:0002097 ! part of skin of body + +[Term] +id: UBERON:0004792 +name: secretion of endocrine pancreas +def: "A secretion that is part of a endocrine pancreas [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002517 +xref: NCIT:C33255 +is_a: UBERON:0004795 ! pancreas secretion +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: BFO:0000050 UBERON:0000016 ! part of endocrine pancreas +relationship: BFO:0000050 UBERON:0000016 ! part of endocrine pancreas + +[Term] +id: UBERON:0004793 +name: secretion of exocrine pancreas +def: "A secretion that is part of a exocrine pancreas [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002518 +xref: NCIT:C33256 +is_a: UBERON:0004795 ! pancreas secretion +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas + [Term] id: UBERON:0004794 name: esophagus secretion +def: "A secretion that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +xref: FMA:79662 +xref: MA:0002514 +xref: NCIT:C52555 is_a: UBERON:0000456 ! secretion of exocrine gland intersection_of: UBERON:0000456 ! secretion of exocrine gland intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus +[Term] +id: UBERON:0004795 +name: pancreas secretion +def: "A secretion that is part of a pancreas [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002516 +xref: NCIT:C13270 +is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: UBERON:0004797 name: blood vessel layer +def: "Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:36296 +xref: MA:0002854 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -38841,6 +58246,12 @@ relationship: BFO:0000050 UBERON:0035965 ! part of wall of blood vessel [Term] id: UBERON:0004802 name: respiratory tract epithelium +def: "The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi." [ISBN:0-683-40008-8, MGI:anna, MP:0010942] +xref: BTO:0000419 +xref: CALOHA:TS-0023 +xref: EMAPA:32827 +xref: MA:0001480 +xref: SCTID:321764001 is_a: UBERON:0004807 ! respiratory system epithelium is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0010499 ! pseudostratified ciliated columnar epithelium @@ -38852,6 +58263,10 @@ relationship: RO:0002433 UBERON:0001004 ! respiratory system [Term] id: UBERON:0004807 name: respiratory system epithelium +def: "An epithelium that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: CALOHA:TS-0023 +xref: EMAPA:32826 +xref: MA:0001823 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -38860,6 +58275,9 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0004808 name: gastrointestinal system epithelium +def: "An epithelium that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:32683 +xref: MA:0001520 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system @@ -38868,14 +58286,37 @@ relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointe [Term] id: UBERON:0004815 name: lower respiratory tract epithelium +def: "An epithelium that is part of a lower respiratory tract [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001481 is_a: UBERON:0004802 ! respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract +[Term] +id: UBERON:0004820 +name: bile duct epithelium +def: "Any epithelium that lines one of the bile ducts." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000417 +xref: MA:0001629 +xref: NCIT:C43616 +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0034932 ! epithelium of biliary system +is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0002394 ! part of bile duct +relationship: BFO:0000050 UBERON:0002394 ! part of bile duct +relationship: BFO:0000051 CL:1000488 ! has part cholangiocyte + [Term] id: UBERON:0004821 name: pulmonary alveolus epithelium +def: "The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO]." [BTO:0003511, MP:0010898] +xref: BTO:0003511 +xref: EMAPA:35121 +xref: FMA:63915 +xref: MA:0001771 +xref: NCIT:C12867 is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0000487 ! simple squamous epithelium intersection_of: UBERON:0000483 ! epithelium @@ -38885,9 +58326,37 @@ relationship: BFO:0000051 CL:0002062 ! has part pulmonary alveolar type 1 cell relationship: RO:0002433 UBERON:0000115 ! lung epithelium relationship: RO:0002433 UBERON:0002299 ! alveolus of lung +[Term] +id: UBERON:0004822 +name: extrahepatic bile duct epithelium +def: "An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000742 +xref: EHDAA:3051 +xref: MA:0002661 +xref: NCIT:C43618 +is_a: UBERON:0004820 ! bile duct epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0003703 ! part of extrahepatic bile duct +relationship: BFO:0000050 UBERON:0003703 ! part of extrahepatic bile duct + +[Term] +id: UBERON:0004823 +name: intrahepatic bile duct epithelium +def: "An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000743 +xref: EHDAA:3053 +xref: MA:0002662 +xref: NCIT:C43617 +is_a: UBERON:0004820 ! bile duct epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0003704 ! part of intrahepatic bile duct +relationship: BFO:0000050 UBERON:0003704 ! part of intrahepatic bile duct + [Term] id: UBERON:0004830 name: respiratory system skeletal muscle +def: "A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001829 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -38896,42 +58365,78 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0004831 name: esophagus skeletal muscle +def: "A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]." [OBOL:automatic] +comment: Most muscle tissue lining the digestive tract is smooth, but part of the externa of the esophagus is skeletal +xref: EMAPA:36523 +xref: MA:0001572 is_a: UBERON:0003898 ! skeletal muscle tissue of trunk intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0003832 ! part of esophagus muscle +[Term] +id: UBERON:0004832 +name: anal region skeletal muscle +def: "A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001530 +is_a: UBERON:0001134 ! skeletal muscle tissue +intersection_of: UBERON:0001134 ! skeletal muscle tissue +intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region +relationship: BFO:0000050 UBERON:0001353 ! part of anal region + [Term] id: UBERON:0004833 name: lip skeletal muscle +def: "A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001578 is_a: UBERON:0001134 ! skeletal muscle tissue intersection_of: UBERON:0001134 ! skeletal muscle tissue intersection_of: BFO:0000050 UBERON:0001833 ! part of lip relationship: BFO:0000050 UBERON:0001833 ! part of lip +[Term] +id: UBERON:0004834 +name: hepatic duct smooth muscle +def: "Smooth muscle tissue in all or part of a hepatic duct." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0001640 +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0001135 ! smooth muscle tissue +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0005171 ! part of hepatic duct +relationship: BFO:0000050 UBERON:0005171 ! part of hepatic duct + [Term] id: UBERON:0004848 name: respiratory system arterial endothelium +def: "An endothelium of artery that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001801 is_a: UBERON:0001917 ! endothelium of artery is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001917 ! endothelium of artery intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003469 ! part of respiratory system artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004849 name: respiratory system venous endothelium +def: "An endothelium of vein that is part of a respiratory system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001811 is_a: UBERON:0001919 ! endothelium of vein is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0001919 ! endothelium of vein intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system relationship: BFO:0000050 UBERON:0003476 ! part of respiratory system venous blood vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004851 name: aorta endothelium +def: "The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall." [MGI:csmith, MP:0009864] +xref: BTO:0000394 +xref: CALOHA:TS-0047 +xref: EFO:0002597 +xref: EMAPA:35134 +xref: MA:0000701 +xref: NCIT:C49190 is_a: UBERON:0004638 ! blood vessel endothelium is_a: UBERON:0004700 ! arterial system endothelium intersection_of: UBERON:0001986 ! endothelium @@ -38941,14 +58446,37 @@ relationship: BFO:0000050 UBERON:0000947 ! part of aorta [Term] id: UBERON:0004852 name: cardiovascular system endothelium +def: "An endothelium that is part of the cardiovascular system." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0001853 +xref: EMAPA:35201 +xref: GAID:519 +xref: MA:0000717 +xref: MESH:D004730 +xref: NCIT:C13053 +xref: TAO:0002171 +xref: VHOG:0001217 +xref: XAO:0000356 +xref: ZFA:0001639 is_a: UBERON:0001986 ! endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0004535 ! part of cardiovascular system relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system +[Term] +id: UBERON:0004854 +name: gastrointestinal system mesentery +def: "A mesentery that is part of a digestive system [Automatically generated definition]." [OBOL:automatic] +xref: MA:0001900 +is_a: UBERON:0002095 ! mesentery +is_a: UBERON:0004782 ! gastrointestinal system serosa +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system + [Term] id: UBERON:0004857 name: skeletal muscle connective tissue +def: "A connective tissue that surrounds a skeletal muscle tissue." [OBOL:automatic] +xref: MA:0002868 is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002221 UBERON:0001134 ! skeletal muscle tissue @@ -38957,6 +58485,10 @@ relationship: RO:0002221 UBERON:0001134 ! skeletal muscle tissue [Term] id: UBERON:0004859 name: eye gland +def: "A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid." [http://orcid.org/0000-0002-6601-2165] +comment: Examples: harderian gland, accessory lacrimal gland, gland of Moll, gland of Zeis, nictitating membrane glands +xref: EMAPA:35334 +xref: MA:0000267 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000970 ! part of eye @@ -38965,6 +58497,10 @@ relationship: BFO:0000050 UBERON:0000970 ! part of eye [Term] id: UBERON:0004861 name: right lung alveolus +def: "An alveolus that is part of a right lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35997 +xref: MA:0001786 +xref: NCIT:C49278 is_a: UBERON:0002299 ! alveolus of lung intersection_of: UBERON:0003215 ! alveolus intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -38973,6 +58509,10 @@ relationship: BFO:0000050 UBERON:0006526 ! part of right lung alveolar system [Term] id: UBERON:0004862 name: left lung alveolus +def: "An alveolus that is part of a left lung [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:19182 +xref: MA:0001777 +xref: NCIT:C49251 is_a: UBERON:0002299 ! alveolus of lung intersection_of: UBERON:0003215 ! alveolus intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung @@ -38981,22 +58521,52 @@ relationship: BFO:0000050 UBERON:0006525 ! part of left lung alveolar system [Term] id: UBERON:0004864 name: vasculature of retina +def: "A vasculature that is part of a retina [Automatically generated definition]." [OBOL:automatic] +xref: FMA:76552 +xref: MESH:D012171 is_a: UBERON:0002203 ! vasculature of eye is_a: UBERON:0036302 ! vasculature of central nervous system plus retina intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000966 ! part of retina relationship: BFO:0000050 UBERON:0000966 ! part of retina -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0004867 +name: orbital cavity +def: "Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000343 +xref: FMA:84961 +xref: SCTID:280541000 +xref: Wikipedia:Orbit_(anatomy) +xref: ZFA:0005558 +is_a: UBERON:0002553 ! anatomical cavity +intersection_of: UBERON:0002553 ! anatomical cavity +intersection_of: RO:0002572 UBERON:0001697 ! orbit of skull +relationship: RO:0002572 UBERON:0001697 ! orbit of skull [Term] id: UBERON:0004872 name: splanchnic layer of lateral plate mesoderm +def: "Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]." [Wikipedia:Lateral_plate_mesoderm#Division_into_layers] +xref: AAO:0011102 +xref: BILA:0000044 +xref: FMA:295568 +xref: Wikipedia:Lateral_plate_mesoderm#Division_into_layers +xref: XAO:0000276 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm [Term] id: UBERON:0004873 name: splanchnopleure +def: "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]." [Wikipedia:Splanchnopleure] +xref: EHDAA2:0001903 +xref: EHDAA:383 +xref: EMAPA:16181 +xref: FMA:295564 +xref: NCIT:C34303 +xref: VHOG:0000558 +xref: Wikipedia:Splanchnopleure is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm relationship: RO:0002131 UBERON:0000925 ! overlaps endoderm @@ -39004,6 +58574,14 @@ relationship: RO:0002131 UBERON:0000925 ! overlaps endoderm [Term] id: UBERON:0004874 name: somatopleure +def: "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]." [Wikipedia:Somatopleure] +xref: EHDAA2:0001847 +xref: EHDAA:381 +xref: EMAPA:16180 +xref: FMA:295566 +xref: NCIT:C34301 +xref: VHOG:0000557 +xref: Wikipedia:Somatopleure is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm relationship: RO:0002131 UBERON:0000924 ! overlaps ectoderm @@ -39011,6 +58589,11 @@ relationship: RO:0002131 UBERON:0000924 ! overlaps ectoderm [Term] id: UBERON:0004880 name: chordamesoderm +def: "The central region of trunk mesoderm. This tissue forms the notochord." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0000478 +xref: EFO:0003426 +xref: TAO:0000091 +xref: ZFA:0000091 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003068 ! part of axial mesoderm relationship: RO:0002160 NCBITaxon:7711 ! Chordata @@ -39018,17 +58601,24 @@ relationship: RO:0002160 NCBITaxon:7711 ! Chordata [Term] id: UBERON:0004883 name: lung mesenchyme +def: "The mass of tissue made up of mesenchymal cells in the lung." [GO:0060484] +xref: EMAPA:32866 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002048 ! part of lung relationship: BFO:0000050 UBERON:0002048 ! part of lung relationship: RO:0002202 UBERON:0003081 ! lateral plate mesoderm -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004893 name: interalveolar septum +def: "A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung." [LG:0012625, Wikipedia:Alveolar_septum] +xref: BTO:0003149 +xref: EMAPA:35433 +xref: MA:0000421 +xref: NCIT:C49473 +xref: Wikipedia:Alveolar_septum is_a: UBERON:0003037 ! septum is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0003037 ! septum @@ -39039,6 +58629,13 @@ relationship: RO:0002220 UBERON:0002299 ! adjacent to alveolus of lung [Term] id: UBERON:0004894 name: alveolar wall +def: "A wall that contains the alveoli." [LG:0012626, MP:0010903] +xref: BTO:0002543 +xref: EMAPA:35120 +xref: FMA:14117 +xref: MA:0002568 +xref: NCIT:C13085 +xref: SCTID:361965008 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall @@ -39049,6 +58646,9 @@ relationship: RO:0002433 UBERON:0002299 ! alveolus of lung [Term] id: UBERON:0004895 name: alveolar smooth muscle +def: "Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus." [LG:0012628] +xref: EMAPA:35122 +xref: MA:0002759 is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002299 ! part of alveolus of lung @@ -39057,6 +58657,11 @@ relationship: BFO:0000050 UBERON:0002299 ! part of alveolus of lung [Term] id: UBERON:0004904 name: neuron projection bundle connecting eye with brain +def: "A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila." [http://orcid.org/0000-0002-6601-2165] +comment: for the vertebrate-specific structure, see UBERON:0000941 (cranial nerve II) +xref: BTO:0000966 +xref: EV:0100351 +xref: TADS:0000232 is_a: UBERON:0000122 ! neuron projection bundle intersection_of: UBERON:0000122 ! neuron projection bundle intersection_of: extends_fibers_into UBERON:0000955 ! brain @@ -39064,32 +58669,56 @@ intersection_of: extends_fibers_into UBERON:0005388 ! photoreceptor array relationship: BFO:0000050 UBERON:0002104 ! part of visual system relationship: extends_fibers_into UBERON:0000955 ! brain relationship: extends_fibers_into UBERON:0005388 ! photoreceptor array -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004905 name: articulation +def: "Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0004770 ! part of articular system [Term] id: UBERON:0004906 name: ectodermal part of digestive tract +def: "A portion of the gut that is derived from ectoderm." [GO:0007439] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004921 ! subdivision of digestive tract intersection_of: UBERON:0004921 ! subdivision of digestive tract intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract intersection_of: RO:0002202 UBERON:0000924 ! ectoderm +[Term] +id: UBERON:0004907 +name: lower digestive tract +def: "The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]." [Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract] +xref: FMA:49179 +xref: galen:LowerGastrointestinalTract +xref: NCIT:C33010 +xref: SCTID:279973004 +xref: Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system +relationship: RO:0002202 UBERON:0001046 ! hindgut + [Term] id: UBERON:0004908 name: upper digestive tract +def: "The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum." [Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract] +xref: FMA:49177 +xref: galen:UpperGastrointestinalTract +xref: NCIT:C33837 +xref: SCTID:181244000 +xref: Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract is_a: UBERON:0004921 ! subdivision of digestive tract relationship: RO:0002202 UBERON:0001041 ! foregut [Term] id: UBERON:0004909 name: epithelium of gonad +def: "An epithelium surrounding a gonad." [OBOL:automatic] +xref: EHDAA:4032 +xref: EHDAA:5931 +xref: NCIT:C32676 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000483 ! epithelium @@ -39099,24 +58728,104 @@ relationship: BFO:0000050 UBERON:0000991 ! part of gonad [Term] id: UBERON:0004911 name: epithelium of female gonad +def: "An epithelium surrounding an ovary." [OBOL:automatic] +xref: BTO:0003661 is_a: UBERON:0004909 ! epithelium of gonad intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary +[Term] +id: UBERON:0004912 +name: biliary bud +xref: EHDAA2:0000171 +xref: EMAPA:16561 +xref: EMAPA_RETIRED:16565 +xref: VHOG:0001351 +is_a: UBERON:0004185 ! endodermal part of digestive tract +is_a: UBERON:0007499 ! epithelial sac +is_a: UBERON:0009497 ! epithelium of foregut-midgut junction +is_a: UBERON:0009854 ! digestive tract diverticulum +relationship: BFO:0000050 UBERON:0002423 ! part of hepatobiliary system +relationship: RO:0002202 UBERON:0004161 ! septum transversum + +[Term] +id: UBERON:0004913 +name: hepatopancreatic ampulla +def: "A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct." [Wikipedia:Ampulla_of_Vater] +xref: CALOHA:TS-2348 +xref: FMA:15076 +xref: GAID:283 +xref: galen:AmpullaOfVater +xref: MESH:D014670 +xref: NCIT:C13011 +xref: SCTID:362200007 +xref: TAO:0005167 +xref: Wikipedia:Ampulla_of_Vater +xref: ZFA:0005167 +is_a: UBERON:0002394 ! bile duct +intersection_of: UBERON:0000058 ! duct +intersection_of: BFO:0000050 UBERON:0001174 ! part of common bile duct +intersection_of: BFO:0000050 UBERON:0004914 ! part of duodenal papilla +relationship: BFO:0000050 UBERON:0001174 ! part of common bile duct +relationship: BFO:0000050 UBERON:0004914 ! part of duodenal papilla + +[Term] +id: UBERON:0004914 +name: duodenal papilla +def: "One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct." [http://medical-dictionary.thefreedictionary.com/duodenal+papilla] +xref: EMAPA:18662 +xref: FMA:15953 +xref: MA:0003107 +xref: NCIT:C119578 +xref: SCTID:245389007 +is_a: UBERON:0034944 ! zone of organ +relationship: BFO:0000050 UBERON:0000320 ! part of duodenal mucosa + +[Term] +id: UBERON:0004915 +name: sphincter of hepatopancreatic ampulla +def: "Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]." [Wikipedia:Sphincter_of_ampulla] +xref: EMAPA:18663 +xref: FMA:15077 +xref: GAID:285 +xref: MESH:D009803 +xref: NCIT:C13065 +xref: SCTID:181271000 +xref: Wikipedia:Sphincter_of_ampulla +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0011185 ! gastrointestinal sphincter +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0004913 ! part of hepatopancreatic ampulla +relationship: BFO:0000050 UBERON:0004913 ! part of hepatopancreatic ampulla + +[Term] +id: UBERON:0004916 +name: anal sphincter +def: "A sphincter muscle that is part of a anal region." [OBOL:automatic] +xref: EMAPA:36052 +is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region +relationship: BFO:0000050 UBERON:0001353 ! part of anal region +relationship: RO:0002216 GO:0030421 ! capable of part of defecation + [Term] id: UBERON:0004921 name: subdivision of digestive tract +def: "A proximal-distal subdivision of the digestive tract." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:71131 is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube intersection_of: subdivision_of UBERON:0001555 ! digestive tract relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: subdivision_of UBERON:0001555 ! digestive tract -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0004923 name: organ component layer +def: "A part of a wall of an organ that forms a layer." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:82485 is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0000060 ! part of anatomical wall relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa @@ -39124,32 +58833,276 @@ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0004924 name: submucosa of pharynx +def: "The tissue underlying the tunica mucosa of the pharynx." [BTO:0002113] +xref: BTO:0002113 +xref: FMA:75144 +xref: SCTID:19594009 is_a: UBERON:0004777 ! respiratory system submucosa is_a: UBERON:0018257 ! submucosa of digestive tract intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx +[Term] +id: UBERON:0004926 +name: submucosa of cystic duct +def: "A submucosa that is part of a cystic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18013 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001152 ! part of cystic duct +relationship: BFO:0000050 UBERON:0001152 ! part of cystic duct + +[Term] +id: UBERON:0004932 +name: submucosa of sigmoid colon +def: "A submucosa that is part of a sigmoid colon [Automatically generated definition]." [OBOL:automatic] +xref: FMA:15027 +is_a: UBERON:0003331 ! submucosa of colon +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon +relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon + +[Term] +id: UBERON:0004934 +name: submucosa of body of stomach +def: "A submucosa that is part of a body of stomach [Automatically generated definition]." [OBOL:automatic] +xref: FMA:17059 +is_a: UBERON:0001200 ! submucosa of stomach +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001161 ! part of body of stomach +relationship: BFO:0000050 UBERON:0001161 ! part of body of stomach + +[Term] +id: UBERON:0004936 +name: submucosa of pyloric antrum +def: "A submucosa that is part of a pyloric antrum [Automatically generated definition]." [OBOL:automatic] +xref: FMA:17060 +is_a: UBERON:0004937 ! submucosa of pylorus +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001165 ! part of pyloric antrum +relationship: BFO:0000050 UBERON:0001165 ! part of pyloric antrum + +[Term] +id: UBERON:0004937 +name: submucosa of pylorus +def: "A submucosa that is part of a pylorus [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:27201 +xref: FMA:17462 +is_a: UBERON:0001200 ! submucosa of stomach +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus + +[Term] +id: UBERON:0004938 +name: submucosa of biliary tree +def: "A submucosa that is part of a biliary tree [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18009 +is_a: UBERON:0000009 ! submucosa +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001173 ! part of biliary tree +relationship: BFO:0000050 UBERON:0001173 ! part of biliary tree + +[Term] +id: UBERON:0004939 +name: submucosa of common bile duct +def: "A submucosa that is part of a common bile duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18011 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001174 ! part of common bile duct +relationship: BFO:0000050 UBERON:0001174 ! part of common bile duct + +[Term] +id: UBERON:0004940 +name: submucosa of common hepatic duct +def: "A submucosa that is part of a common hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18014 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001175 ! part of common hepatic duct +relationship: BFO:0000050 UBERON:0001175 ! part of common hepatic duct + +[Term] +id: UBERON:0004941 +name: submucosa of right hepatic duct +def: "A submucosa that is part of a right hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18015 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001176 ! part of right hepatic duct +relationship: BFO:0000050 UBERON:0001176 ! part of right hepatic duct + +[Term] +id: UBERON:0004942 +name: submucosa of left hepatic duct +def: "A submucosa that is part of a left hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:18017 +is_a: UBERON:0004938 ! submucosa of biliary tree +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0001177 ! part of left hepatic duct +relationship: BFO:0000050 UBERON:0001177 ! part of left hepatic duct + [Term] id: UBERON:0004952 name: submucosa of bronchiole +def: "A submucosa that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:62775 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0004777 ! respiratory system submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0002186 ! part of bronchiole relationship: BFO:0000050 UBERON:0002186 ! part of bronchiole +[Term] +id: UBERON:0004988 +name: mucosa of cystic duct +def: "A mucosa that is part of a cystic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14690 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001152 ! part of cystic duct +relationship: BFO:0000050 UBERON:0001152 ! part of cystic duct + +[Term] +id: UBERON:0004993 +name: mucosa of sigmoid colon +def: "A mucosa that is part of a sigmoid colon [Automatically generated definition]." [OBOL:automatic] +xref: FMA:15026 +is_a: UBERON:0000317 ! colonic mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon +relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon + +[Term] +id: UBERON:0004995 +name: mucosa of body of stomach +def: "A mucosa that is part of a body of stomach [Automatically generated definition]." [OBOL:automatic] +xref: FMA:17054 +is_a: UBERON:0001199 ! mucosa of stomach +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001161 ! part of body of stomach +relationship: BFO:0000050 UBERON:0001161 ! part of body of stomach + +[Term] +id: UBERON:0004997 +name: mucosa of pyloric antrum +def: "A mucosa that is part of a pyloric antrum [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004107 +xref: FMA:17055 +is_a: UBERON:0004998 ! mucosa of pylorus +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001165 ! part of pyloric antrum +relationship: BFO:0000050 UBERON:0001165 ! part of pyloric antrum +relationship: BFO:0000050 UBERON:0004998 ! part of mucosa of pylorus + +[Term] +id: UBERON:0004998 +name: mucosa of pylorus +def: "A mucosa that is part of a pylorus [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004110 +xref: EMAPA:27199 +xref: FMA:17461 +is_a: UBERON:0001199 ! mucosa of stomach +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus + +[Term] +id: UBERON:0004999 +name: mucosa of biliary tree +def: "A mucosa that is part of a biliary tree [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14695 +is_a: UBERON:0000344 ! mucosa +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001173 ! part of biliary tree +relationship: BFO:0000050 UBERON:0001173 ! part of biliary tree + +[Term] +id: UBERON:0005000 +name: mucosa of common bile duct +def: "A mucosa that is part of a common bile duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14688 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001174 ! part of common bile duct +relationship: BFO:0000050 UBERON:0001174 ! part of common bile duct + +[Term] +id: UBERON:0005001 +name: mucosa of common hepatic duct +def: "A mucosa that is part of a common hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14691 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001175 ! part of common hepatic duct +relationship: BFO:0000050 UBERON:0001175 ! part of common hepatic duct + +[Term] +id: UBERON:0005002 +name: mucosa of right hepatic duct +def: "A mucosa that is part of a right hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14692 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001176 ! part of right hepatic duct +relationship: BFO:0000050 UBERON:0001176 ! part of right hepatic duct + +[Term] +id: UBERON:0005003 +name: mucosa of left hepatic duct +def: "A mucosa that is part of a left hepatic duct [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14693 +is_a: UBERON:0004999 ! mucosa of biliary tree +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001177 ! part of left hepatic duct +relationship: BFO:0000050 UBERON:0001177 ! part of left hepatic duct + +[Term] +id: UBERON:0005031 +name: mucosa of upper lip +def: "A mucosa that is part of a upper lip [Automatically generated definition]." [OBOL:automatic] +xref: FMA:59832 +xref: NCIT:C12224 +xref: SCTID:362088009 +is_a: UBERON:0036294 ! mucosa of lip +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0001834 ! part of upper lip +relationship: BFO:0000050 UBERON:0001834 ! part of upper lip + [Term] id: UBERON:0005032 name: mucosa of lower lip +def: "A mucosa that is part of a lower lip [Automatically generated definition]." [OBOL:automatic] +xref: FMA:59833 +xref: NCIT:C12225 +xref: SCTID:362089001 is_a: UBERON:0036294 ! mucosa of lip intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001835 ! part of lower lip relationship: BFO:0000050 UBERON:0001835 ! part of lower lip +[Term] +id: UBERON:0005033 +name: mucosa of gallbladder +def: "A mucosa that is part of a gallbladder [Automatically generated definition]." [OBOL:automatic] +xref: FMA:14662 +xref: SCTID:362196002 +is_a: UBERON:0000344 ! mucosa +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder + [Term] id: UBERON:0005039 name: mucosa of bronchiole +def: "A mucosa that is part of a bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:62774 +xref: SCTID:10887006 is_a: UBERON:0000379 ! tracheal mucosa is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000344 ! mucosa @@ -39159,6 +59112,8 @@ relationship: BFO:0000050 UBERON:0002186 ! part of bronchiole [Term] id: UBERON:0005040 name: mucosa of terminal bronchiole +def: "A mucosa that is part of a terminal bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:263232 is_a: UBERON:0005039 ! mucosa of bronchiole intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole @@ -39167,6 +59122,8 @@ relationship: BFO:0000050 UBERON:0002187 ! part of terminal bronchiole [Term] id: UBERON:0005041 name: mucosa of respiratory bronchiole +def: "A mucosa that is part of a respiratory bronchiole [Automatically generated definition]." [OBOL:automatic] +xref: FMA:263238 is_a: UBERON:0005039 ! mucosa of bronchiole intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole @@ -39175,17 +59132,23 @@ relationship: BFO:0000050 UBERON:0002188 ! part of respiratory bronchiole [Term] id: UBERON:0005056 name: external female genitalia +def: "An external genitalia that is part of a female reproductive system [Automatically generated definition]." [OBOL:automatic] +comment: TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 +xref: BTO:0003100 +xref: EMAPA:30984 +xref: FMA:45649 +xref: galen:FemaleExternalGenitalia +xref: SCTID:362234008 is_a: UBERON:0003134 ! female reproductive organ is_a: UBERON:0004176 ! external genitalia intersection_of: UBERON:0004176 ! external genitalia intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system disjoint_from: UBERON:0009196 ! indifferent external genitalia -property_value: RO:0002175 NCBITaxon:50557 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005057 name: immune organ +def: "An organ that is part of a immune system [Automatically generated definition]." [OBOL:automatic] is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002405 ! part of immune system @@ -39194,6 +59157,9 @@ relationship: BFO:0000050 UBERON:0002405 ! part of immune system [Term] id: UBERON:0005058 name: hemolymphoid system gland +def: "A gland that is part of a hemolymphoid system [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:18766 +xref: MA:0002962 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system @@ -39202,12 +59168,29 @@ relationship: BFO:0000050 UBERON:0002193 ! part of hemolymphoid system [Term] id: UBERON:0005061 name: neural groove +def: "The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds." [GO:0001842, http://orcid.org/0000-0002-6601-2165, Wikipedia:Neural_groove] +xref: AAO:0011071 +xref: EMAPA:35594 +xref: FMA:295624 +xref: NCIT:C34224 +xref: neuronames:1363 +xref: SCTID:361463007 +xref: Wikipedia:Neural_groove +xref: XAO:0000248 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0003075 ! part of neural plate [Term] id: UBERON:0005062 name: neural fold +def: "One of the two elevated edges of the neural groove[GO,MP]." [GO:0001842, MP:0011256, Wikipedia:Neural_fold] +xref: EHDAA2:0001249 +xref: FMA:295618 +xref: NCIT:C34223 +xref: neuronames:1364 +xref: SCTID:361461009 +xref: Wikipedia:Neural_fold +xref: XAO:0004087 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005157 ! epithelial fold is_a: UBERON:0005291 ! embryonic tissue @@ -39216,15 +59199,38 @@ is_a: UBERON:0015212 ! lateral structure relationship: BFO:0000050 UBERON:0005061 ! part of neural groove relationship: BSPO:0000126 UBERON:0005061 ! neural groove +[Term] +id: UBERON:0005064 +name: left ventricular trabecular myocardium +def: "Missing definition for term UBERON:0005064. Please replace it using linked reference." [GO:0003225] +is_a: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle +relationship: BFO:0000050 UBERON:0003382 ! part of cardiac muscle of left ventricle + +[Term] +id: UBERON:0005066 +name: right ventricular trabecular myocardium +def: "Missing definition for term UBERON:0005066. Please replace it using linked reference." [GO:0003227] +is_a: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: UBERON:0004126 ! trabecular layer of ventricle +intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle +relationship: BFO:0000050 UBERON:0003381 ! part of cardiac muscle of right ventricle + [Term] id: UBERON:0005068 name: neural rod +def: "A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]." [GO:0014024, ZFA:0000133] +xref: EFO:0003498 +xref: TAO:0000133 +xref: ZFA:0000133 is_a: UBERON:0016879 ! future central nervous system relationship: RO:0002202 UBERON:0007135 ! neural keel [Term] id: UBERON:0005076 name: hindbrain-spinal cord boundary +def: "An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord." [OBOL:automatic] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction @@ -39237,6 +59243,10 @@ relationship: RO:0002220 UBERON:0002240 ! adjacent to spinal cord [Term] id: UBERON:0005082 name: tube lumen +def: "A hole in a tube[GO]." [GO:0060609] +xref: AEO:0000078 +xref: EHDAA2:0004618 +xref: RETIRED_EHDAA2:0003078 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002219 UBERON:0000025 ! tube @@ -39245,6 +59255,8 @@ relationship: RO:0002219 UBERON:0000025 ! tube [Term] id: UBERON:0005085 name: ectodermal placode +def: "An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]." [GO:0060788] +xref: AEO:0000218 is_a: UBERON:0001048 ! primordium is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm @@ -39252,6 +59264,8 @@ relationship: BFO:0000050 UBERON:0000924 ! part of ectoderm [Term] id: UBERON:0005090 name: muscle structure +def: "Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]." [GO:0061061] +xref: FMA:30316 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000051 CL:0000187 ! has part muscle cell relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa @@ -39259,17 +59273,25 @@ relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0005092 name: right horn of sinus venosus +xref: EHDAA2:0001841 +xref: EHDAA:484 +xref: EMAPA:16239 +xref: FMA:70318 +xref: VHOG:0000489 is_a: UBERON:0002050 ! embryonic structure relationship: BSPO:0000121 UBERON:0002063 ! sinus venosus [Term] id: UBERON:0005153 name: epithelial bud +def: "A bud is a protrusion that forms from an epithelial sheet by localized folding." [GO:0060572] +xref: BTO:0001639 is_a: UBERON:0005157 ! epithelial fold [Term] id: UBERON:0005156 name: reproductive structure +def: "Any anatomical structure that is part of the reproductive system." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0010000 ! multicellular anatomical structure intersection_of: UBERON:0010000 ! multicellular anatomical structure intersection_of: BFO:0000050 UBERON:0000990 ! part of reproductive system @@ -39278,11 +59300,13 @@ relationship: BFO:0000050 UBERON:0000990 ! part of reproductive system [Term] id: UBERON:0005157 name: epithelial fold +def: "An epithelial sheet bent on a linear axis." [GO:0060571] is_a: UBERON:0000483 ! epithelium [Term] id: UBERON:0005158 name: parenchyma of central nervous system +def: "The functional tissue of the central nervous system consisting of neurons and glial cells." [CL:tm, https://github.com/obophenotype/uberon/issues/8] is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000353 ! parenchyma @@ -39292,18 +59316,44 @@ relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system [Term] id: UBERON:0005162 name: multi cell part structure +def: "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part." [CARO:0001000] +xref: AAO:0011000 +xref: CARO:0001000 +xref: FMA:83115 is_a: UBERON:0000061 ! anatomical structure relationship: RO:0002473 GO:0005575 ! cellular_component [Term] id: UBERON:0005169 name: interstitial tissue +def: "Connective tissue between the cellular elements of a structure." [http://medical-dictionary.thefreedictionary.com/tissue] +xref: FMA:86301 +xref: SCTID:85293002 is_a: UBERON:0003891 ! stroma -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0005171 +name: hepatic duct +def: "Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion)." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0000741 +xref: EHDAA:3049 +xref: EMAPA:16843 +xref: FMA:71891 +xref: galen:HepaticDuct +xref: MA:0000357 +xref: NCIT:C32730 +xref: SCTID:245399002 +xref: VHOG:0000219 +is_a: UBERON:0002394 ! bile duct +relationship: RO:0002176 UBERON:0001174 ! common bile duct +relationship: RO:0002176 UBERON:0002107 ! liver [Term] id: UBERON:0005172 name: abdomen element +def: "An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000522 +xref: SCTID:272631008 is_a: UBERON:0005173 ! abdominal segment element intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -39312,6 +59362,8 @@ relationship: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0005173 name: abdominal segment element +def: "An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000529 is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -39320,6 +59372,8 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0005174 name: dorsal region element +def: "An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0001901 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0001137 ! part of dorsum @@ -39328,6 +59382,8 @@ relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0005177 name: trunk region element +def: "An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000516 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -39336,6 +59392,8 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0005178 name: thoracic cavity element +def: "An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000557 is_a: UBERON:0002075 ! viscus is_a: UBERON:0005181 ! thoracic segment organ intersection_of: UBERON:0000062 ! organ @@ -39345,6 +59403,8 @@ relationship: RO:0001025 UBERON:0002224 ! thoracic cavity [Term] id: UBERON:0005181 name: thoracic segment organ +def: "An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0000563 is_a: UBERON:0005177 ! trunk region element intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk @@ -39353,14 +59413,77 @@ relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk [Term] id: UBERON:0005194 name: thoracic vein +def: "A vein that is part of a thorax [Automatically generated definition]." [OBOL:automatic] +xref: MA:0002235 +xref: NCIT:C53142 +xref: SCTID:281472008 is_a: UBERON:0001638 ! vein is_a: UBERON:0003834 ! thoracic segment blood vessel intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk +[Term] +id: UBERON:0005203 +name: trachea gland +def: "A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen." [http://medical-dictionary.thefreedictionary.com/tracheal+glands, https://github.com/obophenotype/uberon/issues/1197, ISBN:1451113412, MGI:Anna, PMID:15973734] +xref: EMAPA:36574 +xref: FMA:7473 +xref: MA:0002937 +xref: SCTID:197423006 +is_a: UBERON:8410077 ! airway submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea +intersection_of: BFO:0000051 CL:0000159 ! has part seromucus secreting cell +relationship: BFO:0000050 UBERON:0003126 ! part of trachea + +[Term] +id: UBERON:0005221 +name: liver right lobe parenchyma +def: "A parenchyma that is part of a right lobe of liver [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001010 +xref: EMAPA:18317 +xref: FMA:71657 +xref: VHOG:0000840 +is_a: UBERON:0001280 ! liver parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: BFO:0000050 UBERON:0001114 ! part of right lobe of liver + +[Term] +id: UBERON:0005222 +name: liver left lobe parenchyma +def: "A parenchyma that is part of a left lobe of liver [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001002 +xref: EMAPA:18310 +xref: FMA:71658 +xref: VHOG:0000839 +is_a: UBERON:0001280 ! liver parenchyma +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: BFO:0000050 UBERON:0001115 ! part of left lobe of liver + +[Term] +id: UBERON:0005233 +name: medial-nasal process ectoderm +def: "An ectoderm that is part of a medial nasal prominence [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0001078 +xref: EMAPA:16809 +xref: FMA:312675 +xref: VHOG:0000803 +is_a: UBERON:0000924 ! ectoderm +is_a: UBERON:0014702 ! frontonasal process epithelium +intersection_of: UBERON:0000924 ! ectoderm +intersection_of: BFO:0000050 UBERON:0004068 ! part of medial nasal prominence +relationship: BFO:0000050 UBERON:0004068 ! part of medial nasal prominence + [Term] id: UBERON:0005234 name: optic eminence ectoderm +def: "An ectoderm that is part of a optic eminence [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA:940 +xref: EMAPA:16539 +xref: RETIRED_EHDAA2:0001309 +xref: VHOG:0001105 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0004348 ! part of optic eminence @@ -39369,11 +59492,19 @@ relationship: BFO:0000050 UBERON:0004348 ! part of optic eminence [Term] id: UBERON:0005239 name: basal plate metencephalon +xref: EHDAA2:0001154 +xref: EMAPA:17078 +xref: VHOG:0000320 is_a: UBERON:0004064 ! neural tube basal plate [Term] id: UBERON:0005243 name: interventricular septum endocardium +def: "An endocardium that is part of a interventricular septum [Automatically generated definition]." [OBOL:automatic] +xref: EHDAA2:0000886 +xref: EHDAA2:0000887 +xref: FMA:83584 +xref: VHOG:0000615 is_a: UBERON:0002165 ! endocardium intersection_of: UBERON:0002165 ! endocardium intersection_of: BFO:0000050 UBERON:0002094 ! part of interventricular septum @@ -39382,6 +59513,9 @@ relationship: BFO:0000050 UBERON:0002094 ! part of interventricular septum [Term] id: UBERON:0005248 name: bulbus cordis myocardium +def: "A myocardium that is part of a bulbus cordis [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:36488 +xref: VHOG:0000609 is_a: UBERON:0002349 ! myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0004706 ! part of bulbus cordis @@ -39390,6 +59524,8 @@ relationship: BFO:0000050 UBERON:0004706 ! part of bulbus cordis [Term] id: UBERON:0005250 name: stomatodeum gland +def: "A gland that is part of a stomodeum." [OBOL:automatic] +xref: VHOG:0000658 is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0000930 ! part of stomodeum @@ -39398,6 +59534,10 @@ relationship: BFO:0000050 UBERON:0000930 ! part of stomodeum [Term] id: UBERON:0005251 name: yolk sac cavity +def: "An anatomical cavity that is part of a yolk sac [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:16055 +xref: FMA:63942 +xref: VHOG:0000843 is_a: UBERON:0002553 ! anatomical cavity is_a: UBERON:0007473 ! lumen of epithelial sac is_a: UBERON:0012466 ! extraembryonic cavity @@ -39408,6 +59548,16 @@ relationship: RO:0002572 UBERON:0001040 ! yolk sac [Term] id: UBERON:0005253 name: head mesenchyme +def: "Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells." [ISBN:0683400088, MP:0011260] +xref: EFO:0003492 +xref: EHDAA2:0000732 +xref: EHDAA:179 +xref: EMAPA:16098 +xref: EMAPA_RETIRED:16269 +xref: FMA:76622 +xref: TAO:0000113 +xref: VHOG:0000332 +xref: ZFA:0000113 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme @@ -39418,6 +59568,14 @@ relationship: BFO:0000050 UBERON:0009142 ! part of entire embryonic mesenchyme [Term] id: UBERON:0005256 name: trunk mesenchyme +def: "Mesenchyme that is part of a developing trunk." [OBOL:automatic] +xref: EFO:0003485 +xref: EHDAA2:0002092 +xref: EHDAA:377 +xref: EMAPA:16177 +xref: TAO:0000081 +xref: VHOG:0000281 +xref: ZFA:0000081 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme @@ -39429,12 +59587,26 @@ relationship: BFO:0000050 UBERON:0009142 ! part of entire embryonic mesenchyme [Term] id: UBERON:0005290 name: myelencephalon +def: "The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]." [BTO:0000758, Wikipedia:Myelencephalon] +xref: BTO:0000758 +xref: CALOHA:TS-0607 +xref: CALOHA:TS-2365 +xref: DHBA:10662 +xref: EHDAA2:0001207 +xref: EHDAA:5526 +xref: EMAPA:17082 +xref: HBA:9512 +xref: MA:0000205 +xref: VHOG:0000456 +xref: Wikipedia:Myelencephalon is_a: UBERON:0004733 ! segmental subdivision of hindbrain relationship: RO:0002495 UBERON:0010096 ! future myelencephalon [Term] id: UBERON:0005291 name: embryonic tissue +def: "A portion of tissue that is part of an embryo." [OBOL:automatic] +xref: CALOHA:TS-2100 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -39443,6 +59615,12 @@ relationship: BFO:0000050 UBERON:0002050 ! part of embryonic structure [Term] id: UBERON:0005292 name: extraembryonic tissue +def: "Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo." [https://orcid.org/0000-0002-6601-2165] +xref: BTO:0003360 +xref: CALOHA:TS-2119 +xref: EFO:0001406 +xref: MAT:0000061 +xref: MIAA:0000061 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component @@ -39451,6 +59629,8 @@ relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic compone [Term] id: UBERON:0005316 name: endocardial endothelium +def: "The endothelial lining of the endocardium." [UBERON:cjm] +xref: FMA:83596 is_a: UBERON:0008307 ! heart endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0002165 ! part of endocardium @@ -39459,6 +59639,8 @@ relationship: BFO:0000050 UBERON:0002165 ! part of endocardium [Term] id: UBERON:0005317 name: pulmonary artery endothelium +def: "An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]." [GO:0061155] +xref: BTO:0000137 is_a: UBERON:0001917 ! endothelium of artery intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery @@ -39467,6 +59649,8 @@ relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery [Term] id: UBERON:0005334 name: oral lamina propria +def: "A lamina propria that is part of a mucosa of oral region." [OBOL:automatic] +xref: EMAPA:26947 is_a: UBERON:0000030 ! lamina propria intersection_of: UBERON:0000030 ! lamina propria intersection_of: BFO:0000050 UBERON:0003343 ! part of mucosa of oral region @@ -39475,6 +59659,10 @@ relationship: BFO:0000050 UBERON:0003343 ! part of mucosa of oral region [Term] id: UBERON:0005337 name: outflow tract of ventricle +def: "A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]." [Wikipedia:Ventricular_outflow_tract] +xref: FMA:13225 +xref: Wikipedia:Ventricular_outflow_tract +xref: XAO:0004140 is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -39483,6 +59671,11 @@ relationship: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle [Term] id: UBERON:0005338 name: outflow tract aortic component +def: "An outflow tract that is part of a aorta." [OBOL:automatic] +xref: EHDAA2:0001353 +xref: EMAPA:17329 +xref: MA:0000101 +xref: VHOG:0001394 is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: BFO:0000050 UBERON:0000947 ! part of aorta @@ -39491,11 +59684,17 @@ relationship: BFO:0000050 UBERON:0000947 ! part of aorta [Term] id: UBERON:0005339 name: outflow tract pulmonary component +xref: EHDAA2:0001359 +xref: EHDAA:4401 +xref: EMAPA:17330 +xref: MA:0000102 +xref: VHOG:0001395 is_a: UBERON:0004145 ! outflow tract [Term] id: UBERON:0005388 name: photoreceptor array +def: "An array of photoreceptors and any supporting cells found in an eye." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0000970 ! part of eye @@ -39507,6 +59706,7 @@ relationship: RO:0002473 CL:0000210 ! photoreceptor cell [Term] id: UBERON:0005389 name: transparent eye structure +def: "A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0000970 ! part of eye relationship: RO:0000086 PATO:0000964 @@ -39514,11 +59714,35 @@ relationship: RO:0000086 PATO:0000964 [Term] id: UBERON:0005396 name: carotid artery segment +def: "One of: the common carotid artery, or its branches, the external and internal carotid arteries." [https://sourceforge.net/tracker/?func=detail&aid=3486870&group_id=76834&atid=994764, Wikipedia:Carotid_artery] +xref: AAO:0010217 +xref: BTO:0000168 +xref: CALOHA:TS-0116 +xref: EFO:0000818 +xref: EHDAA:6385 +xref: EMAPA:18609 +xref: EV:0100379 +xref: FMA:70504 +xref: GAID:478 +xref: galen:CarotidArtery +xref: MA:0001925 +xref: MAT:0000501 +xref: MESH:D002339 +xref: NCIT:C12687 +xref: SCTID:362040006 +xref: SCTID:69105007 +xref: TAO:0000097 +xref: VHOG:0000266 +xref: Wikipedia:Carotid_artery +xref: ZFA:0000097 is_a: UBERON:0004573 ! systemic artery [Term] id: UBERON:0005398 name: female reproductive gland +def: "A sex gland that is part of a female reproductive system." [OBOL:automatic] +xref: BTO:0000254 +xref: MA:0000383 is_a: UBERON:0003937 ! reproductive gland intersection_of: UBERON:0003937 ! reproductive gland intersection_of: BFO:0000050 UBERON:0000474 ! part of female reproductive system @@ -39527,6 +59751,20 @@ relationship: BFO:0000050 UBERON:0003134 ! part of female reproductive organ [Term] id: UBERON:0005409 name: alimentary part of gastrointestinal system +def: "The part of the digestive system that excludes the hepatobiliary system." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0000058 +xref: CALOHA:TS-0407 +xref: EHDAA2:0000110 +xref: EHDAA:514 +xref: EMAPA:16246 +xref: FMA:71132 +xref: GAID:294 +xref: galen:GastrointestinalTract +xref: MA:0000323 +xref: MESH:D041981 +xref: NCIT:C12378 +xref: SCTID:373871007 +xref: VHOG:0000412 is_a: UBERON:0000467 ! anatomical system relationship: BFO:0000050 UBERON:0001007 ! part of digestive system relationship: RO:0002492 UBERON:0000066 ! fully formed stage @@ -39534,6 +59772,13 @@ relationship: RO:0002492 UBERON:0000066 ! fully formed stage [Term] id: UBERON:0005419 name: pectoral appendage bud +def: "A limb bud that develops into a forelimb or pectoral fin." [OBOL:automatic] +comment: at this time we have no need to name a more specific 'pectoral fin bud' class, but we may in future +xref: EFO:0003430 +xref: TAO:0000141 +xref: VHOG:0001754 +xref: VHOG_RETIRED:0001259 +xref: ZFA:0000141 is_a: UBERON:0004357 ! paired limb/fin bud intersection_of: UBERON:0004357 ! paired limb/fin bud intersection_of: RO:0002387 UBERON:0004710 ! pectoral appendage @@ -39544,6 +59789,14 @@ relationship: RO:0002387 UBERON:0004710 ! pectoral appendage [Term] id: UBERON:0005421 name: pectoral appendage apical ectodermal ridge +def: "An apical ectodermal ridge that is part of a pectoral appendage bud." [OBOL:automatic] +xref: EFO:0003487 +xref: EHDAA2:0000138 +xref: EMAPA:16778 +xref: TAO:0000085 +xref: TAO:0000736 +xref: VHOG:0001064 +xref: ZFA:0000085 is_a: UBERON:0004356 ! apical ectodermal ridge intersection_of: UBERON:0004356 ! apical ectodermal ridge intersection_of: BFO:0000050 UBERON:0005419 ! part of pectoral appendage bud @@ -39553,15 +59806,23 @@ relationship: RO:0002202 UBERON:0003372 ! pectoral appendage bud ectoderm [Term] id: UBERON:0005423 name: developing anatomical structure +xref: AEO:0000125 +xref: CALOHA:TS-2122 +xref: EHDAA2:0003125 +xref: FMA:292313 +xref: MIAA:0000019 is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002215 GO:0032502 ! capable of developmental process -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0005425 name: presumptive neural retina +def: "Portion of tissue that is the inner layer of the optic cup and will become the neural retina." [ZFIN:curator] +xref: EHDAA2:0001304 +xref: EMAPA:16675 +xref: TAO:0001071 +xref: VHOG:0000490 +xref: ZFA:0001071 is_a: UBERON:0006598 ! presumptive structure is_a: UBERON:0010312 ! immature eye intersection_of: UBERON:0006598 ! presumptive structure @@ -39572,6 +59833,14 @@ relationship: RO:0002387 UBERON:0003902 ! retinal neural layer [Term] id: UBERON:0005426 name: lens vesicle +def: "Portion of tissue that gives rise to the lens." [https://sourceforge.net/tracker/?func=detail&atid=994726&aid=3514998&group_id=76834, ZFIN:curator] +xref: EHDAA2:0000983 +xref: EHDAA:4737 +xref: EMAPA:17163 +xref: SCTID:361510002 +xref: TAO:0002205 +xref: VHOG:0001163 +xref: ZFA:0001679 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure relationship: RO:0002202 UBERON:0003073 ! lens placode @@ -39579,6 +59848,9 @@ relationship: RO:0002202 UBERON:0003073 ! lens placode [Term] id: UBERON:0005427 name: corneal primordium +def: "Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea." [ZFIN:ZDB-PUB-061010-3] +xref: TAO:0002188 +xref: ZFA:0001688 is_a: UBERON:0000479 ! tissue is_a: UBERON:0001048 ! primordium is_a: UBERON:0010312 ! immature eye @@ -39588,6 +59860,13 @@ relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye [Term] id: UBERON:0005428 name: vagal neural crest +def: "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]." [ZFIN:curator] +xref: EHDAA2:0002156 +xref: EHDAA:669 +xref: TAO:0000818 +xref: VHOG:0001208 +xref: XAO:0004191 +xref: ZFA:0000818 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0002342 ! part of neural crest @@ -39595,6 +59874,13 @@ relationship: BFO:0000050 UBERON:0002342 ! part of neural crest [Term] id: UBERON:0005432 name: aortic sac +def: "The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates." [MP:0012510] +xref: EHDAA2:0004145 +xref: EHDAA:9826 +xref: EMAPA:36461 +xref: FMA:71008 +xref: RETIRED_EHDAA2:0000133 +xref: SCTID:361527005 is_a: UBERON:0001637 ! artery is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0003498 ! heart blood vessel @@ -39604,13 +59890,55 @@ relationship: RO:0002202 UBERON:0004363 ! pharyngeal arch artery [Term] id: UBERON:0005434 name: cervical region +xref: FMA:24219 +xref: SCTID:123958008 is_a: UBERON:0011676 ! subdivision of organism along main body axis relationship: BFO:0000050 UBERON:0000974 ! part of neck relationship: RO:0002160 NCBITaxon:8287 ! Sarcopterygii +[Term] +id: UBERON:0005436 +name: common hepatic artery +def: "In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:." [Wikipedia:Common_hepatic_artery] +xref: EHDAA2:0000308 +xref: EHDAA:8570 +xref: FMA:14771 +xref: galen:CommonHepaticArtery +xref: MA:0003094 +xref: SCTID:244263001 +xref: Wikipedia:Common_hepatic_artery +is_a: UBERON:0004573 ! systemic artery +relationship: RO:0002252 UBERON:0001640 ! celiac artery + +[Term] +id: UBERON:0005446 +name: foramen rotundum +def: "The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa." [Wikipedia:Foramen_rotundum] +xref: AAO:0000194 +xref: EHDAA2:0000552 +xref: EHDAA:10629 +xref: EMAPA:18712 +xref: FMA:53154 +xref: SCTID:369439002 +xref: VHOG:0001543 +xref: Wikipedia:Foramen_rotundum +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0013685 ! foramen of skull +intersection_of: UBERON:0013685 ! foramen of skull +intersection_of: BFO:0000050 UBERON:0001677 ! part of sphenoid bone +intersection_of: RO:0002570 UBERON:0000377 ! maxillary nerve +relationship: BFO:0000050 UBERON:0001677 ! part of sphenoid bone +relationship: RO:0002570 UBERON:0000377 ! maxillary nerve + [Term] id: UBERON:0005460 name: left vitelline vein +def: "A vitelline vein that is in the left side of a multicellular organism." [OBOL:automatic] +xref: EHDAA2:0000971 +xref: EMAPA:16380 +xref: EMAPA:16698 +xref: FMA:70307 +xref: SCTID:361446008 is_a: UBERON:0005487 ! vitelline vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0005487 ! vitelline vein @@ -39620,6 +59948,12 @@ relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0005472 name: right vitelline vein +def: "A vitelline vein that is in the right side of a multicellular organism." [OBOL:automatic] +xref: EHDAA2:0001766 +xref: EMAPA:16381 +xref: EMAPA:16699 +xref: FMA:70306 +xref: SCTID:361445007 is_a: UBERON:0005487 ! vitelline vein is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0005487 ! vitelline vein @@ -39629,12 +59963,27 @@ relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0005478 name: sulcus limitans of neural tube +def: "A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]." [http://medical-dictionary.thefreedictionary.com/Sulcus+limitans, http://www.ncbi.nlm.nih.gov/books/NBK10047] +xref: BAMS:slim +xref: BAMS:slm +xref: neuronames:629 is_a: UBERON:0006846 ! surface groove relationship: BFO:0000050 UBERON:0005496 ! part of neural tube lateral wall [Term] id: UBERON:0005487 name: vitelline vein +def: "The paired veins that carry blood from the yolk sac back to the embryo." [MGI:csmith, MP:0010666] +xref: EMAPA:36021 +xref: FMA:70305 +xref: NCIT:C34329 +xref: RETIRED_EHDAA2:0002209 +xref: SCTID:2730004 +xref: SCTID:308832003 +xref: VHOG:0000401 +xref: Wikipedia:Vitelline_veins +xref: XAO:0000376 +xref: XAO:0004147 is_a: UBERON:0004365 ! vitelline blood vessel is_a: UBERON:0013140 ! systemic vein intersection_of: UBERON:0001638 ! vein @@ -39644,18 +59993,45 @@ relationship: RO:0002179 UBERON:0001040 ! yolk sac [Term] id: UBERON:0005496 name: neural tube lateral wall +def: "Portion of tissue on the side of the lumen of the neural tube." [ZFA:0001435] +xref: EHDAA2:0001257 +xref: EHDAA:2873 +xref: EHDAA:912 +xref: EMAPA:16166 +xref: TAO:0001435 +xref: VHOG:0000513 +xref: ZFA:0001435 is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001049 ! part of neural tube [Term] id: UBERON:0005497 name: non-neural ectoderm +comment: Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998). +xref: EFO:0003643 +xref: EHDAA:257 +xref: EMAPA:16074 +xref: RETIRED_EHDAA2:0001273 +xref: TAO:0001178 +xref: VHOG:0001372 +xref: XAO:0004091 +xref: ZFA:0001178 is_a: UBERON:0000479 ! tissue is_a: UBERON:0004121 ! ectoderm-derived structure [Term] id: UBERON:0005498 name: primitive heart tube +def: "Multi-tissue structure that arises from the heart rudiment and will become the heart tube." [ZFA:0000149] +xref: EHDAA2:0001512 +xref: EHDAA:424 +xref: EHDAA:436 +xref: EMAPA:16215 +xref: FMA:321916 +xref: SCTID:361522004 +xref: TAO:0000149 +xref: Wikipedia:Primitive_heart_tube +xref: ZFA:0000149 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0000922 ! part of embryo @@ -39664,6 +60040,9 @@ relationship: RO:0002202 UBERON:0004291 ! heart rudiment [Term] id: UBERON:0005501 name: rhombomere lateral wall +def: "A neural tube lateral wall that is part of a rhombomere." [OBOL:automatic] +xref: EMAPA:32819 +xref: EMAPA:35364 is_a: UBERON:0005496 ! neural tube lateral wall intersection_of: UBERON:0005496 ! neural tube lateral wall intersection_of: BFO:0000050 UBERON:0001892 ! part of rhombomere @@ -39672,6 +60051,14 @@ relationship: BFO:0000050 UBERON:0001892 ! part of rhombomere [Term] id: UBERON:0005563 name: trigeminal neural crest +def: "Cranial neural crest which gives rise to the trigeminal ganglion." [ZFA:0000080] +xref: EFO:0003484 +xref: EHDAA2:0002083 +xref: EHDAA:667 +xref: EMAPA:16170 +xref: TAO:0000080 +xref: VHOG:0000269 +xref: ZFA:0000080 is_a: UBERON:0003099 ! cranial neural crest is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0007530 ! migrating mesenchyme population @@ -39680,6 +60067,14 @@ relationship: BFO:0000050 UBERON:0007213 ! part of mesenchyme derived from head [Term] id: UBERON:0005564 name: gonad primordium +def: "Portion of tissue that gives rise to the immature gonad." [ZFA:0001262] +xref: EFO:0003651 +xref: EHDAA:5927 +xref: EMAPA:17204 +xref: RETIRED_EHDAA2:0002148 +xref: TAO:0001262 +xref: WBbt:0008366 +xref: ZFA:0001262 is_a: UBERON:0001048 ! primordium relationship: BFO:0000050 UBERON:0000990 ! part of reproductive system relationship: RO:0002387 UBERON:0000991 ! gonad @@ -39687,6 +60082,10 @@ relationship: RO:0002387 UBERON:0000991 ! gonad [Term] id: UBERON:0005594 name: head somite +def: "Somite located in the head region, caudal to the otic vesicle." [PMID:11830559] +xref: EHDAA2:0003437 +xref: EMAPA:16172 +xref: XAO:0000313 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0002329 ! somite is_a: UBERON:0005291 ! embryonic tissue @@ -39698,6 +60097,11 @@ relationship: RO:0002202 UBERON:0009617 ! head paraxial mesoderm [Term] id: UBERON:0005597 name: lung primordium +def: "A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum." [XAO:0001002] +xref: AAO:0011059 +xref: EFO:0002578 +xref: EMAPA:36007 +xref: XAO:0001002 is_a: UBERON:0001048 ! primordium relationship: BFO:0000050 UBERON:0008947 ! part of respiratory primordium relationship: RO:0002202 UBERON:0001041 ! foregut @@ -39706,14 +60110,50 @@ relationship: RO:0002387 UBERON:0000170 ! pair of lungs [Term] id: UBERON:0005598 name: trunk somite +def: "A somite that is part of a trunk." [OBOL:automatic] +xref: AAO:0010385 +xref: EHDAA2:0003438 +xref: EMAPA:16184 +xref: XAO:0000314 is_a: UBERON:0002329 ! somite intersection_of: UBERON:0002329 ! somite intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk +[Term] +id: UBERON:0005602 +name: dorsal mesogastrium +def: "The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum." [Wikipedia:Dorsal_mesentery] +xref: EHDAA2:0000416 +xref: EHDAA:3001 +xref: EMAPA:17025 +xref: MA:0001618 +xref: NCIT:C34142 +xref: VHOG:0000352 +xref: Wikipedia:Dorsal_mesentery +is_a: UBERON:0003281 ! mesentery of stomach +relationship: BFO:0000050 UBERON:0002296 ! part of dorsal mesentery +relationship: BFO:0000050 UBERON:0003281 ! part of mesentery of stomach + +[Term] +id: UBERON:0005604 +name: extrahepatic part of hepatic duct +xref: EMAPA:16844 +xref: MA:0001636 +xref: VHOG:0000215 +is_a: UBERON:0002394 ! bile duct +relationship: BFO:0000050 UBERON:0003703 ! part of extrahepatic bile duct +relationship: BFO:0000050 UBERON:0005171 ! part of hepatic duct + [Term] id: UBERON:0005613 name: left dorsal aorta +xref: EHDAA2:0000936 +xref: EHDAA:404 +xref: EMAPA:16205 +xref: MA:0000478 +xref: SCTID:361403005 +xref: VHOG:0000484 is_a: UBERON:0000947 ! aorta is_a: UBERON:0003513 ! trunk blood vessel relationship: BFO:0000050 UBERON:0005805 ! part of dorsal aorta @@ -39721,6 +60161,17 @@ relationship: BFO:0000050 UBERON:0005805 ! part of dorsal aorta [Term] id: UBERON:0005614 name: lens anterior epithelium +def: "A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0000984 +xref: EHDAA:9059 +xref: EMAPA:17304 +xref: EMAPA:17839 +xref: FMA:70612 +xref: MA:0001302 +xref: NCIT:C33641 +xref: RETIRED_EHDAA2:0000976 +xref: SCTID:362521008 +xref: VHOG:0001425 is_a: UBERON:0001803 ! epithelium of lens intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000965 ! part of lens of camera-type eye @@ -39728,9 +60179,53 @@ intersection_of: RO:0002220 UBERON:0001804 ! adjacent to capsule of lens relationship: RO:0002220 UBERON:0000389 ! adjacent to lens cortex relationship: RO:0002220 UBERON:0001804 ! adjacent to capsule of lens +[Term] +id: UBERON:0005616 +name: mesenteric artery +def: "Arteries which arise from the abdominal aorta and distribute to most of the intestines." [MESH:A07.231.114.565, Wikipedia:Mesenteric_artery] +xref: BTO:0000779 +xref: EHDAA2:0001123 +xref: EHDAA:4343 +xref: EMAPA:17312 +xref: MA:0002003 +xref: MESH:D008638 +xref: NCIT:C52975 +xref: SCTID:281084003 +xref: VHOG:0001117 +xref: Wikipedia:Mesenteric_artery +xref: XAO:0000370 +is_a: UBERON:0012254 ! abdominal aorta artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0000160 ! intestine +relationship: RO:0002178 UBERON:0000160 ! intestine + +[Term] +id: UBERON:0005617 +name: mesenteric vein +def: "A vein that returns blood from the intestines." [MESH:A07.231.908.670.385, Wikipedia:Mesenteric_vein] +xref: BTO:0002781 +xref: EHDAA:4442 +xref: EMAPA:17348 +xref: MA:0002177 +xref: MESH:D008642 +xref: NCIT:C53055 +xref: RETIRED_EHDAA2:0001125 +xref: SCTID:304045008 +xref: Wikipedia:Mesenteric_vein +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: RO:0002179 UBERON:0000160 ! intestine +relationship: RO:0002179 UBERON:0000160 ! intestine + [Term] id: UBERON:0005622 name: right dorsal aorta +xref: EHDAA2:0001720 +xref: EHDAA:406 +xref: EMAPA:16206 +xref: MA:0000479 +xref: SCTID:361404004 +xref: VHOG:0000485 is_a: UBERON:0000947 ! aorta is_a: UBERON:0003513 ! trunk blood vessel relationship: BFO:0000050 UBERON:0005805 ! part of dorsal aorta @@ -39738,12 +60233,30 @@ relationship: BFO:0000050 UBERON:0005805 ! part of dorsal aorta [Term] id: UBERON:0005631 name: extraembryonic membrane +def: "Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo." [ISBN:0073040584] +xref: EHDAA2:0004714 +xref: FMA:305915 +xref: SCTID:362840007 is_a: UBERON:0000158 ! membranous layer relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component +[Term] +id: UBERON:0005637 +name: pyloric region epithelium +def: "An epithelium that is part of a pylorus." [OBOL:automatic] +xref: EHDAA2:0001582 +xref: EMAPA:17633 +xref: RETIRED_EHDAA2:0001927 +is_a: UBERON:0001276 ! epithelium of stomach +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus + [Term] id: UBERON:0005638 name: anterior chamber epithelium +def: "An epithelium that is part of a anterior chamber of eyeball." [OBOL:automatic] +xref: EHDAA2:0000130 is_a: UBERON:0015808 ! eye epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball @@ -39752,6 +60265,10 @@ relationship: BFO:0000050 UBERON:0001766 ! part of anterior chamber of eyeball [Term] id: UBERON:0005656 name: lens vesicle epithelium +def: "An epithelium that is part of a lens vesicle." [OBOL:automatic] +xref: EHDAA2:0000987 +xref: EMAPA:17165 +xref: VHOG:0000532 is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0005426 ! part of lens vesicle @@ -39760,6 +60277,13 @@ relationship: BFO:0000050 UBERON:0005426 ! part of lens vesicle [Term] id: UBERON:0005662 name: 4th arch ectoderm +def: "An ectoderm that is part of a pharyngeal arch 4." [OBOL:automatic] +xref: EHDAA2:0004032 +xref: EMAPA:16762 +xref: EMAPA:16764 +xref: EMAPA:16768 +xref: RETIRED_EHDAA2:0000094 +xref: VHOG:0001095 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 @@ -39768,6 +60292,13 @@ relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 [Term] id: UBERON:0005666 name: 4th arch endoderm +def: "An endoderm that is part of a pharyngeal arch 4." [OBOL:automatic] +xref: EHDAA2:0004033 +xref: EMAPA:16765 +xref: EMAPA:16767 +xref: EMAPA:16769 +xref: RETIRED_EHDAA2:0000095 +xref: VHOG:0001092 is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 @@ -39776,6 +60307,12 @@ relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 [Term] id: UBERON:0005669 name: peritoneal cavity mesothelium +def: "A mesothelium that is part of a peritoneal cavity." [OBOL:automatic] +xref: BTO:0003156 +xref: EHDAA2:0001447 +xref: EMAPA:16139 +xref: FMA:18147 +xref: SCTID:34073007 is_a: UBERON:0001136 ! mesothelium intersection_of: UBERON:0001136 ! mesothelium intersection_of: RO:0001025 UBERON:0001179 ! peritoneal cavity @@ -39784,6 +60321,8 @@ relationship: RO:0001025 UBERON:0001179 ! peritoneal cavity [Term] id: UBERON:0005672 name: right lung endothelium +def: "An endothelium that is part of a right lung." [OBOL:automatic] +xref: EHDAA2:0001755 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003364 ! epithelium of right lung @@ -39793,15 +60332,35 @@ intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0005673 name: left lung endothelium +def: "An endothelium that is part of a left lung." [OBOL:automatic] +xref: EHDAA2:0000961 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0001986 ! endothelium is_a: UBERON:0003365 ! epithelium of left lung intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung +[Term] +id: UBERON:0005685 +name: midgut dorsal mesentery +def: "A dorsal mesentery that is part of a midgut." [OBOL:automatic] +xref: EMAPA:16722 +xref: EMAPA:17040 +xref: EMAPA:18671 +xref: RETIRED_EHDAA2:0001187 +xref: SCTID:361434009 +is_a: UBERON:0002296 ! dorsal mesentery +intersection_of: UBERON:0002296 ! dorsal mesentery +intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut +relationship: BFO:0000050 UBERON:0001045 ! part of midgut + [Term] id: UBERON:0005688 name: lens vesicle cavity +def: "An anatomical cavity that is part of a lens vesicle." [OBOL:automatic] +xref: EHDAA2:0000986 +xref: EMAPA:17164 +xref: VHOG:0000531 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0005426 ! lens vesicle @@ -39811,6 +60370,12 @@ relationship: RO:0002572 UBERON:0005426 ! lens vesicle [Term] id: UBERON:0005691 name: 4th arch mesenchyme +def: "Mesenchyme that is part of a pharyngeal arch 4." [OBOL:automatic] +xref: EHDAA2:0000096 +xref: EHDAA:1677 +xref: EMAPA:16770 +xref: FMA:295702 +xref: VHOG:0001052 is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 @@ -39819,15 +60384,48 @@ relationship: BFO:0000050 UBERON:0003115 ! part of pharyngeal arch 4 [Term] id: UBERON:0005702 name: optic eminence mesenchyme +def: "Mesenchyme that is part of a optic eminence." [OBOL:automatic] +xref: EHDAA:942 +xref: EMAPA:16324 +xref: RETIRED_EHDAA2:0001310 +xref: VHOG:0001073 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004348 ! part of optic eminence relationship: BFO:0000050 UBERON:0004348 ! part of optic eminence +[Term] +id: UBERON:0005711 +name: foregut duodenum mesentery +def: "A mesentery of duodenum that is part of a foregut." [OBOL:automatic] +xref: EHDAA2:0000564 +is_a: UBERON:0003397 ! mesentery of duodenum +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0003397 ! mesentery of duodenum +intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut +relationship: BFO:0000050 UBERON:0001041 ! part of foregut +relationship: RO:0002202 UBERON:0011642 ! oral epithelium from ectoderm + +[Term] +id: UBERON:0005712 +name: midgut duodenum mesentery +def: "A mesentery of duodenum that is part of a midgut." [OBOL:automatic] +xref: EHDAA2:0001193 +is_a: UBERON:0003284 ! mesentery of midgut +is_a: UBERON:0003397 ! mesentery of duodenum +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0003397 ! mesentery of duodenum +intersection_of: BFO:0000050 UBERON:0001045 ! part of midgut +relationship: RO:0002202 UBERON:0011642 ! oral epithelium from ectoderm + [Term] id: UBERON:0005720 name: hindbrain venous system +def: "A venous system that is part of a hindbrain." [OBOL:automatic] +xref: EHDAA2:0000776 +xref: EMAPA:18632 +xref: VHOG:0001322 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004582 ! venous system intersection_of: UBERON:0004582 ! venous system @@ -39837,6 +60435,7 @@ relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain [Term] id: UBERON:0005726 name: chemosensory system +xref: BILA:0000139 is_a: UBERON:0001032 ! sensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: RO:0002215 GO:0007606 ! capable of sensory perception of chemical stimulus @@ -39845,6 +60444,11 @@ relationship: RO:0002215 GO:0007606 ! capable of sensory perception of chemical [Term] id: UBERON:0005728 name: extraembryonic mesoderm +xref: EHDAA2:0000474 +xref: EMAPA:31862 +xref: EMAPA:31863 +xref: FMA:296719 +xref: VHOG:0000616 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005292 ! extraembryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue @@ -39854,6 +60458,9 @@ relationship: RO:0002202 UBERON:0008780 ! inner cell mass derived epiblast [Term] id: UBERON:0005729 name: pectoral appendage field +def: "A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme." [OBOL:automatic] +xref: TAO:0001453 +xref: ZFA:0001453 is_a: UBERON:0005732 ! paired limb/fin field is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0005732 ! paired limb/fin field @@ -39863,6 +60470,7 @@ relationship: RO:0002387 UBERON:0003413 ! pectoral appendage bud mesenchyme [Term] id: UBERON:0005732 name: paired limb/fin field +def: "A ring of cells capable of forming a limb or paired fin[Gilbert,modified]." [ISBN:9780878932504] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -39875,6 +60483,12 @@ relationship: RO:0002385 UBERON:0004357 ! paired limb/fin bud [Term] id: UBERON:0005734 name: tunica adventitia of blood vessel +def: "The outermost layer of a blood vessel, composed mainly of fibrous tissue." [ISBN:0073040584, Wikipedia:Tunica_externa_(vessels)] +xref: BTO:0002010 +xref: EMAPA:36299 +xref: NCIT:C33818 +xref: SCTID:61066005 +xref: Wikipedia:Tunica_externa_(vessels) is_a: UBERON:0004797 ! blood vessel layer is_a: UBERON:0005742 ! adventitia relationship: RO:0000086 PATO:0002462 @@ -39883,6 +60497,12 @@ relationship: RO:0002473 UBERON:0011824 ! fibrous connective tissue [Term] id: UBERON:0005740 name: tunica intima of artery +def: "A tunica intima that is part of a artery." [OBOL:automatic] +xref: EMAPA:36293 +xref: EV:0100028 +xref: FMA:14272 +xref: galen:IntimaOfArtery +xref: SCTID:40022005 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004797 ! blood vessel layer intersection_of: UBERON:0002523 ! tunica intima @@ -39892,13 +60512,22 @@ relationship: BFO:0000050 UBERON:0000415 ! part of artery wall [Term] id: UBERON:0005742 name: adventitia +def: "An outermost connective tissue covering of an organ, vessel, or other structure[WP]." [Wikipedia:Adventitia] +xref: BTO:0002010 +xref: FMA:45635 +xref: SCTID:30180000 +xref: Wikipedia:Adventitia is_a: UBERON:0004923 ! organ component layer relationship: RO:0002473 UBERON:0002384 ! connective tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0005744 name: bone foramen +def: "Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves." [TAO:curator] +xref: AAO:0010438 +xref: TAO:0001736 +xref: VHOG:0001760 +xref: ZFA:0005386 is_a: UBERON:0004111 ! anatomical conduit intersection_of: UBERON:0004111 ! anatomical conduit intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element @@ -39907,17 +60536,23 @@ relationship: BFO:0000050 UBERON:0001474 ! part of bone element [Term] id: UBERON:0005764 name: acellular membrane +def: "An acellular anatomical structure that is the bounding layer of a anatomical structure." [OBOL:automatic] +xref: FMA:63871 is_a: UBERON:0000476 ! acellular anatomical structure intersection_of: UBERON:0000476 ! acellular anatomical structure intersection_of: RO:0002007 UBERON:0000061 ! bounding layer of anatomical structure relationship: RO:0002007 UBERON:0000061 ! bounding layer of anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0005769 name: basement membrane of epithelium +def: "An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Basement_membrane] +xref: AAO:0010596 +xref: FMA:63872 +xref: GAID:915 +xref: NCIT:C13191 +xref: SCTID:68989006 +xref: Wikipedia:Basement_membrane is_a: UBERON:0005764 ! acellular membrane relationship: BFO:0000050 UBERON:0000483 ! part of epithelium relationship: BFO:0000051 GO:0005587 ! has part collagen type IV trimer @@ -39928,6 +60563,10 @@ relationship: RO:0002473 GO:0005604 ! basement membrane [Term] id: UBERON:0005800 name: section of aorta +def: "Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle." [ncithesaurus:Aortic_Segment] +xref: FMA:13087 +xref: NCIT:C34027 +xref: SCTID:119203005 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0000947 ! part of aorta @@ -39935,20 +60574,64 @@ relationship: BFO:0000050 UBERON:0000947 ! part of aorta [Term] id: UBERON:0005805 name: dorsal aorta +def: "The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GO:0035907, https://sourceforge.net/p/geneontology/ontology-requests/8525/] +xref: AAO:0011029 +xref: BTO:0004673 +xref: EHDAA:402 +xref: EMAPA:18606 +xref: SCTID:338637006 +xref: TAO:0000014 +xref: VHOG:0000264 +xref: Wikipedia:Dorsal_aorta +xref: XAO:0000051 +xref: ZFA:0000014 is_a: UBERON:0000947 ! aorta is_a: UBERON:0003513 ! trunk blood vessel relationship: BFO:0000050 UBERON:0002201 ! part of vasculature of trunk relationship: RO:0002202 UBERON:0001917 ! endothelium of artery relationship: RO:0002202 UBERON:0003064 ! intermediate mesoderm +[Term] +id: UBERON:0005806 +name: portal system +def: "In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]." [Wikipedia:Portal_venous_system] +xref: FMA:45628 +xref: MESH:D011168 +xref: NCIT:C33344 +xref: SCTID:362063001 +xref: Wikipedia:Portal_venous_system +is_a: UBERON:0002049 ! vasculature + [Term] id: UBERON:0005844 name: spinal cord segment +xref: BIRNLEX:2665 +xref: FMA:62420 +xref: MA:0003080 +xref: SCTID:278748001 is_a: UBERON:0001948 ! regional part of spinal cord +[Term] +id: UBERON:0005845 +name: caudal segment of spinal cord +def: "A spinal cord segment that adjacent_to a caudal region." [OBOL:automatic] +comment: for spinal cord segments, we treat coccygeal/caudal as synonyms - we only differentiate where bone is concerned +xref: FMA:256635 +xref: MA:0003084 +xref: neuronames:1656 +xref: SCTID:278753006 +is_a: UBERON:0005844 ! spinal cord segment +intersection_of: UBERON:0005844 ! spinal cord segment +intersection_of: RO:0002220 UBERON:0006071 ! adjacent to caudal region +relationship: RO:0002220 UBERON:0006071 ! adjacent to caudal region + [Term] id: UBERON:0005856 name: developing mesenchymal condensation +def: "A delimited region of dense mesenchyme within looser mesenchyme." [AEO:0000148] +xref: AEO:0000148 +xref: EHDAA2_RETIRED:0003148 +xref: EHDAA:8979 is_a: UBERON:0007524 ! dense mesenchyme tissue is_a: UBERON:0011585 ! cell condensation relationship: RO:0002473 CL:0000335 ! mesenchyme condensation cell @@ -39956,6 +60639,12 @@ relationship: RO:0002473 CL:0000335 ! mesenchyme condensation cell [Term] id: UBERON:0005863 name: cartilaginous condensation +def: "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes." [GO:curator] +xref: AEO:0000147 +xref: EHDAA2_RETIRED:0003147 +xref: EMAPA:32731 +xref: VSAO:0000092 +xref: XAO:0004022 is_a: UBERON:0005856 ! developing mesenchymal condensation relationship: BFO:0000050 UBERON:0004288 ! part of skeleton relationship: RO:0002202 UBERON:0005866 ! pre-cartilage condensation @@ -39963,6 +60652,8 @@ relationship: RO:0002202 UBERON:0005866 ! pre-cartilage condensation [Term] id: UBERON:0005865 name: pre-muscle condensation +xref: AEO:0000149 +xref: EHDAA2_RETIRED:0003149 is_a: UBERON:0005856 ! developing mesenchymal condensation intersection_of: UBERON:0005856 ! developing mesenchymal condensation intersection_of: RO:0002473 CL:0000680 ! muscle precursor cell @@ -39973,6 +60664,10 @@ relationship: RO:0002473 CL:0000680 ! muscle precursor cell [Term] id: UBERON:0005866 name: pre-cartilage condensation +def: "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts." [AEO:0000150, AEO:JB] +xref: AEO:0000150 +xref: EHDAA2:0003150 +xref: EMAPA:32736 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005856 ! developing mesenchymal condensation relationship: BFO:0000050 UBERON:0004288 ! part of skeleton @@ -39981,19 +60676,53 @@ relationship: RO:0002387 UBERON:0007844 ! cartilage element [Term] id: UBERON:0005867 name: mandibular prominence +def: "The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip." [ISBN:0-683-40008-8, MP:0010939] +xref: EHDAA2:0001061 +xref: EHDAA:5871 +xref: EMAPA:17355 +xref: FMA:293051 +xref: NCIT:C34204 +xref: Wikipedia:Mandibular_prominence is_a: UBERON:0012314 ! embryonic facial prominence relationship: BFO:0000050 UBERON:0000166 ! part of oral opening relationship: RO:0002202 UBERON:0007237 ! 1st arch mandibular component +[Term] +id: UBERON:0005868 +name: maxillary prominence +def: "The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw." [ISBN:0-683-40008-8, MP:0010940] +xref: EHDAA2:0001070 +xref: EHDAA:5877 +xref: EMAPA:17359 +xref: FMA:293049 +xref: NCIT:C34206 +xref: SCTID:346355001 +xref: Wikipedia:Maxillary_prominence +is_a: UBERON:0002050 ! embryonic structure +relationship: RO:0002202 UBERON:0007238 ! 1st arch maxillary component + [Term] id: UBERON:0005902 name: occipital region +def: "Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles." [TAO:0001414, UBERONREF:0000007] +xref: AAO:0010199 +xref: BTO:0004675 +xref: FMA:49187 +xref: neuronames:2431 +xref: SCTID:362618001 +xref: TAO:0001414 +xref: XAO:0003173 +xref: ZFA:0001414 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0003128 ! part of cranium [Term] id: UBERON:0005906 name: serous sac +def: "Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]." [FMA:9689, https://github.com/obophenotype/uberon/issues/86] +comment: See notes for serous membrane +xref: FMA:9689 +xref: SCTID:362890006 is_a: UBERON:0000062 ! organ relationship: BFO:0000051 UBERON:0000042 ! has part serous membrane relationship: BFO:0000051 UBERON:0002553 ! has part anatomical cavity @@ -40001,6 +60730,8 @@ relationship: BFO:0000051 UBERON:0002553 ! has part anatomical cavity [Term] id: UBERON:0005911 name: endo-epithelium +def: "Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]." [FMA:69065] +xref: FMA:69065 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000483 ! epithelium @@ -40009,16 +60740,36 @@ intersection_of: RO:0002202 UBERON:0000925 ! endoderm [Term] id: UBERON:0005944 name: axial skeleton plus cranial skeleton +def: "Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]." [FMA:71221, https://github.com/obophenotype/uberon/issues/44, https://github.com/obophenotype/uberon/wiki/The-axial-skeleton, VSAO:0000056, Wikipedia:Axial_skeleton] +xref: AAO:0000963 +xref: EMAPA:17214 +xref: MA:0000308 +xref: NCIT:C32172 +xref: SCTID:361725000 +xref: VSAO:0000056 +xref: Wikipedia:Axial_skeleton +xref: XAO:0004011 is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0011137 ! part of axial skeletal system relationship: RO:0002170 UBERON:0002091 {gci_filler="NCBITaxon:7776", gci_relation="BFO:0000050"} ! appendicular skeleton relationship: RO:0002202 UBERON:0003089 ! sclerotome relationship: RO:0002433 UBERON:0001434 ! skeletal system -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0005945 +name: neurocranial trabecula +xref: EFO:0003677 +xref: TAO:0001321 +xref: ZFA:0001321 +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0003932 ! cartilage element of chondrocranium +relationship: BFO:0000050 UBERON:0003112 ! part of olfactory region [Term] id: UBERON:0005946 name: outflow tract of atrium +def: "An outflow tract that is part of a cardiac atrium." [OBOL:automatic] +xref: FMA:14141 is_a: UBERON:0004145 ! outflow tract intersection_of: UBERON:0004145 ! outflow tract intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium @@ -40028,6 +60779,10 @@ relationship: RO:0002150 UBERON:0002082 ! cardiac ventricle [Term] id: UBERON:0005953 name: outflow part of right ventricle +def: "Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk." [MP:0010428] +xref: FMA:7216 +xref: NCIT:C61368 +xref: SCTID:244379003 is_a: UBERON:0005337 ! outflow tract of ventricle intersection_of: UBERON:0005337 ! outflow tract of ventricle intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle @@ -40038,6 +60793,10 @@ relationship: RO:0002202 UBERON:0009889 ! secondary heart field [Term] id: UBERON:0005956 name: outflow part of left ventricle +def: "Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta." [MP:0010429] +xref: FMA:9473 +xref: SCTID:264070001 +xref: Wikipedia:Aortic_vestibule is_a: UBERON:0005337 ! outflow tract of ventricle intersection_of: UBERON:0005337 ! outflow tract of ventricle intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle @@ -40046,6 +60805,8 @@ relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle [Term] id: UBERON:0005965 name: outflow part of right atrium +def: "Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA]." [FMA:9550, FMA:FMA] +xref: FMA:9550 is_a: UBERON:0005946 ! outflow tract of atrium intersection_of: UBERON:0005946 ! outflow tract of atrium intersection_of: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium @@ -40054,6 +60815,8 @@ relationship: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium [Term] id: UBERON:0005966 name: outflow part of left atrium +def: "An outflow tract of atrium that is part of a left atrium." [OBOL:automatic] +xref: FMA:9551 is_a: UBERON:0005946 ! outflow tract of atrium intersection_of: UBERON:0005946 ! outflow tract of atrium intersection_of: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium @@ -40062,6 +60825,10 @@ relationship: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium [Term] id: UBERON:0005979 name: crista terminalis +def: "The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium." [MP:0010495] +xref: FMA:9236 +xref: SCTID:277693004 +xref: Wikipedia:Crista_terminalis is_a: UBERON:0000064 ! organ part is_a: UBERON:0004120 ! mesoderm-derived structure relationship: BFO:0000050 UBERON:0002078 ! part of right cardiac atrium @@ -40070,6 +60837,7 @@ relationship: RO:0002433 UBERON:0002078 ! right cardiac atrium [Term] id: UBERON:0005983 name: heart layer +def: "The laminar structure of the heart." [MP:0010545] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -40080,6 +60848,9 @@ relationship: RO:0002433 UBERON:0000948 ! heart [Term] id: UBERON:0005985 name: coronary vessel +def: "Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation." [MP:0010551] +xref: MESH:D003331 +xref: Wikipedia:Coronary_circulation is_a: UBERON:0000055 ! vessel is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000055 ! vessel @@ -40087,9 +60858,26 @@ intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002433 UBERON:0000948 ! heart +[Term] +id: UBERON:0005988 +name: atrium myocardial trabecula +def: "The supporting bundles of muscular fibers lining the walls of the atrial myocardium." [MP:0010581, ZFA:0005810] +xref: ZFA:0005810 +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0000440 ! trabecula +intersection_of: BFO:0000050 UBERON:0002302 ! part of myocardium of atrium +relationship: BFO:0000050 UBERON:0002302 ! part of myocardium of atrium +relationship: BFO:0000050 UBERON:0004124 ! part of myocardium trabecular layer +relationship: RO:0002433 UBERON:0002302 ! myocardium of atrium + [Term] id: UBERON:0005989 name: atrioventricular septum +def: "The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve." [MP:0010592] +xref: FMA:7136 +xref: SCTID:280151006 +xref: Wikipedia:Atrioventricular_septum is_a: UBERON:0002099 ! cardiac septum is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002099 ! cardiac septum @@ -40102,6 +60890,11 @@ relationship: RO:0002220 UBERON:0002084 ! adjacent to heart left ventricle [Term] id: UBERON:0006002 name: vitelline artery +def: "The paired arteries that carry blood to the yolk sac from the dorsal aorta." [MP:0010664, Wikipedia:Vitelline_arteries] +comment: Development notes:; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult[MP:0010664] +xref: EHDAA2:0002208 +xref: EMAPA:16207 +xref: Wikipedia:Vitelline_arteries is_a: UBERON:0001637 ! artery is_a: UBERON:0004365 ! vitelline blood vessel intersection_of: UBERON:0001637 ! artery @@ -40112,6 +60905,8 @@ relationship: RO:0002252 UBERON:0005805 ! dorsal aorta [Term] id: UBERON:0006003 name: integumentary adnexa +def: "Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers." [http://code.google.com/p/caro2/issues/detail?id=5, http://orcid.org/0000-0002-6601-2165] +xref: Wikipedia:Skin_appendage is_a: UBERON:0000064 ! organ part relationship: BFO:0000050 UBERON:0002416 ! part of integumental system @@ -40124,9 +60919,101 @@ intersection_of: BSPO:0000122 UBERON:0000033 ! head relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: BSPO:0000122 UBERON:0000033 ! head +[Term] +id: UBERON:0006068 +name: bone of tail +def: "A bone that is part of a post-anal tail." [OBOL:automatic] +xref: EMAPA:18042 +xref: MA:0000696 +is_a: UBERON:0001474 ! bone element +intersection_of: UBERON:0001474 ! bone element +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + +[Term] +id: UBERON:0006071 +name: caudal region +def: "Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this." [http://orcid.org/0000-0002-6601-2165] +xref: XAO:0000087 +is_a: UBERON:0011676 ! subdivision of organism along main body axis +relationship: BFO:0000050 UBERON:0000154 ! part of posterior region of body +relationship: BSPO:0000099 UBERON:0001245 ! anus +relationship: RO:0002551 UBERON:0006076 ! caudal region of vertebral column + +[Term] +id: UBERON:0006072 +name: cervical region of vertebral column +def: "That portion of the spine comprising the cervical vertebrae. The neck area of the spine." [http://medical-dictionary.thefreedictionary.com/] +xref: AAO:0000092 +xref: BTO:0004148 +xref: EHDAA2:0000238 +xref: EHDAA:5051 +xref: EMAPA:17215 +xref: FMA:24138 +xref: MA:0003154 +xref: NCIT:C69313 +xref: SCTID:260488005 +is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: subdivision_of UBERON:0005434 ! cervical region +relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton +relationship: BFO:0000050 UBERON:0012477 ! part of dorsal part of neck +relationship: subdivision_of UBERON:0005434 ! cervical region + +[Term] +id: UBERON:0006073 +name: thoracic region of vertebral column +def: "That part of the spine comprising the thoracic vertebrae." [http://medical-dictionary.thefreedictionary.com/] +xref: BTO:0004150 +xref: EHDAA:5063 +xref: EMAPA:17396 +xref: FMA:9140 +xref: MA:0003155 +xref: NCIT:C69315 +xref: SCTID:243931006 +is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: subdivision_of UBERON:0000915 ! thoracic segment of trunk +relationship: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of trunk +relationship: BFO:0000050 UBERON:0014477 ! part of thoracic skeleton +relationship: subdivision_of UBERON:0000915 ! thoracic segment of trunk + +[Term] +id: UBERON:0006076 +name: caudal region of vertebral column +def: "Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae." [UBERONREF:0000006] +xref: AAO:0000082 +xref: EMAPA:18043 +xref: MA:0003158 +is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: subdivision_of UBERON:0006071 ! caudal region +relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton +relationship: BFO:0000050 UBERON:0006071 ! part of caudal region +relationship: subdivision_of UBERON:0006071 ! caudal region + +[Term] +id: UBERON:0006077 +name: subdivision of vertebral column +def: "A collection of all skeletal elements in some subdivision of the vertebral column." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:16201 +is_a: UBERON:0000075 ! subdivision of skeletal system +intersection_of: UBERON:0000075 ! subdivision of skeletal system +intersection_of: subdivision_of UBERON:0001130 ! vertebral column +relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column +relationship: BFO:0000050 UBERON:0001137 ! part of dorsum +relationship: subdivision_of UBERON:0001130 ! vertebral column + [Term] id: UBERON:0006207 name: aortico-pulmonary spiral septum +def: "The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions." [MP:0010650, Wikipedia:Aorticopulmonary_septum] +xref: CALOHA:TS-2409 +xref: EHDAA2:0000136 +xref: EHDAA:2592 +xref: EMAPA:16827 +xref: VHOG:0000502 +xref: Wikipedia:Aorticopulmonary_septum is_a: UBERON:0004142 ! outflow tract septum is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0002099 ! cardiac septum @@ -40139,6 +61026,14 @@ relationship: RO:0002220 UBERON:0005805 ! adjacent to dorsal aorta [Term] id: UBERON:0006211 name: buccopharyngeal membrane +def: "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx." [MP:0012521] +xref: EHDAA2:0000189 +xref: EHDAA:536 +xref: EMAPA:16259 +xref: FMA:313607 +xref: SCTID:361412007 +xref: VHOG:0000380 +xref: Wikipedia:Buccopharyngeal_membrane is_a: UBERON:0003037 ! septum relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0006264 ! part of mouth-foregut junction @@ -40150,12 +61045,69 @@ relationship: RO:0002254 UBERON:0000925 ! endoderm [Term] id: UBERON:0006218 name: common atrial chamber +xref: EHDAA:1267 +xref: EMAPA:16342 +xref: RETIRED_EHDAA2:0000268 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium +[Term] +id: UBERON:0006227 +name: ethmoid bone primordium +xref: EHDAA2:0000456 +xref: EHDAA:8363 +xref: EMAPA:18023 +xref: FMA:312597 +is_a: UBERON:0001048 ! primordium +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0001679 ! ethmoid bone +relationship: BFO:0000050 UBERON:0002517 ! part of basicranium +relationship: BFO:0000050 UBERON:0011241 ! part of ethmoid region +relationship: RO:0002202 UBERON:0007213 ! mesenchyme derived from head neural crest +relationship: RO:0002387 UBERON:0001679 ! ethmoid bone + +[Term] +id: UBERON:0006235 +name: foregut-midgut junction +def: "An anatomical junctions that overlaps the foregut and midgut." [OBOL:automatic] +xref: EHDAA2:0000569 +xref: EHDAA:526 +xref: EMAPA:16363 +xref: VHOG:0000291 +is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0001041 ! foregut +intersection_of: RO:0002176 UBERON:0001045 ! midgut +relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract +relationship: RO:0002176 UBERON:0001041 ! foregut +relationship: RO:0002176 UBERON:0001045 ! midgut + +[Term] +id: UBERON:0006236 +name: tetrapod frontal bone primordium +xref: EHDAA2:0000577 +xref: EHDAA:9540 +xref: EMAPA:18017 +xref: FMA:312589 +is_a: UBERON:0001048 ! primordium +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0000209 ! tetrapod frontal bone +relationship: RO:0002387 UBERON:0000209 ! tetrapod frontal bone + [Term] id: UBERON:0006238 name: future brain +def: "The embryonic precursor of the brain." [NLX:94995] +xref: BAMS:Enc +xref: BTO:0004726 +xref: EFO:0003431 +xref: EHDAA:300 +xref: EHDAA:830 +xref: EMAPA:16089 +xref: FMA:312967 +xref: RETIRED_EHDAA2:0000591 +xref: TAO:0000146 +xref: ZFA:0000146 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0002346 ! part of neurectoderm relationship: RO:0002387 UBERON:0000955 ! brain @@ -40163,6 +61115,10 @@ relationship: RO:0002387 UBERON:0000955 ! brain [Term] id: UBERON:0006239 name: future central tendon +def: "A tendon that has the potential to develop into a central tendon." [OBOL:automatic] +xref: EHDAA2:0000593 +xref: EHDAA:4118 +xref: EMAPA:25035 is_a: UBERON:0000043 ! tendon is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0006598 ! presumptive structure @@ -40175,14 +61131,42 @@ relationship: RO:0002387 UBERON:0006670 ! central tendon of diaphragm [Term] id: UBERON:0006241 name: future spinal cord +xref: EFO:0003438 +xref: EHDAA2:0000674 +xref: EHDAA:898 +xref: EMAPA:16092 +xref: EMAPA:16755 +xref: TAO:0000417 +xref: ZFA:0000417 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: RO:0002387 UBERON:0001049 ! neural tube relationship: RO:0002387 UBERON:0002240 ! spinal cord +[Term] +id: UBERON:0006242 +name: gallbladder primordium +def: "A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops." [ISBN:0815318960, XAO:0004205] +xref: EHDAA2:0000700 +xref: EHDAA:3047 +xref: EMAPA:16713 +xref: XAO:0004205 +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0002110 ! gallbladder +relationship: BFO:0000050 UBERON:0004912 ! part of biliary bud +relationship: RO:0002202 UBERON:0001152 ! cystic duct +relationship: RO:0002387 UBERON:0002110 ! gallbladder + [Term] id: UBERON:0006264 name: mouth-foregut junction +def: "An anatomical junctions that overlaps the mouth and foregut." [OBOL:automatic] +xref: EHDAA:534 +xref: EMAPA:16258 +xref: RETIRED_EHDAA2:0001205 +xref: VHOG:0000592 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002131 UBERON:0000165 ! overlaps mouth @@ -40194,6 +61178,12 @@ relationship: RO:0002131 UBERON:0001041 ! overlaps foregut [Term] id: UBERON:0006267 name: notochordal plate +def: "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord." [VHOG:0001212] +xref: EHDAA2:0001278 +xref: EHDAA:264 +xref: EMAPA:16101 +xref: NCIT:C34231 +xref: VHOG:0001212 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue @@ -40203,13 +61193,41 @@ relationship: RO:0002202 UBERON:0006268 ! notochordal process [Term] id: UBERON:0006268 name: notochordal process +def: "A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot." [http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/05embryonicperiod.htm] +comment: The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. +xref: EHDAA2:0001279 +xref: EHDAA:224 +xref: EMAPA:16102 +xref: FMA:293135 +xref: NCIT:C34232 +xref: VHOG:0001213 is_a: UBERON:0005423 ! developing anatomical structure relationship: RO:0002160 NCBITaxon:7711 ! Chordata relationship: RO:0002202 UBERON:0000924 ! ectoderm +[Term] +id: UBERON:0006271 +name: orbital fissure +def: "Either of two openings transmitting nerves and blood vessels to or from the orbit." [http://www.merriam-webster.com/medical/orbital%20fissure] +xref: EHDAA2:0001328 +xref: EHDAA:10648 +xref: EMAPA:18717 +xref: SCTID:280546005 +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0013685 ! foramen of skull +intersection_of: UBERON:0013685 ! foramen of skull +intersection_of: BFO:0000050 UBERON:0001697 ! part of orbit of skull +relationship: BFO:0000050 UBERON:0001697 ! part of orbit of skull + [Term] id: UBERON:0006279 name: pleuroperitoneal canal +def: "Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity." [ISBN:0124020607, VHOG:0001505] +xref: EHDAA2:0001481 +xref: EHDAA:4128 +xref: EMAPA:17707 +xref: SCTID:361413002 +xref: VHOG:0001505 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0005291 ! embryonic tissue intersection_of: UBERON:0003914 ! epithelial tube @@ -40223,14 +61241,44 @@ relationship: RO:0002176 UBERON:0002402 ! pleural cavity [Term] id: UBERON:0006283 name: future cardiac ventricle +def: "Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle." [ZFA:0001719] +comment: The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum[WP] +xref: EHDAA2:0001531 +xref: EMAPA:16350 +xref: FMA:71006 +xref: NCIT:C34160 +xref: SCTID:361524003 +xref: TAO:0002231 +xref: Wikipedia:Embryonic_ventricle +xref: ZFA:0001719 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0004141 ! part of heart tube relationship: BFO:0000050 UBERON:0005498 ! part of primitive heart tube relationship: RO:0002387 UBERON:0002082 ! cardiac ventricle +[Term] +id: UBERON:0006293 +name: spleen primordium +def: "A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]." [ISBN:0123747295, MP:0011263] +xref: EHDAA2:0001904 +xref: EHDAA:3003 +xref: EMAPA:18535 +xref: XAO:0000326 +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0002050 ! embryonic structure +is_a: UBERON:0003104 ! mesenchyme +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0005291 ! embryonic tissue +relationship: BFO:0000050 UBERON:0005602 ! part of dorsal mesogastrium +relationship: RO:0002202 UBERON:0004872 ! splanchnic layer of lateral plate mesoderm + [Term] id: UBERON:0006304 name: future trigeminal ganglion +comment: See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/13 and https://github.com/obophenotype/uberon/issues/693 -- consider merging into trigeminal ganglion, as this complicates the model +xref: EHDAA:924 +xref: EMAPA:16663 +xref: RETIRED_EHDAA2:0002089 is_a: UBERON:0003869 ! presumptive ganglion relationship: RO:0002202 UBERON:0005563 ! trigeminal neural crest relationship: RO:0002387 UBERON:0001675 ! trigeminal ganglion @@ -40239,6 +61287,12 @@ relationship: RO:0002494 UBERON:0003070 ! trigeminal placode complex [Term] id: UBERON:0006311 name: chamber of eyeball +def: "A segment of the eyeball that is filled with refractive media." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0002085 +xref: FMA:58071 +xref: MA:0002459 +xref: NCIT:C32301 +xref: SCTID:280540004 is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000063 ! organ subunit @@ -40250,12 +61304,21 @@ relationship: RO:0001015 UBERON:0006312 ! ocular refractive media [Term] id: UBERON:0006312 name: ocular refractive media +def: "Body substance in a liquid or semi-solid state in the eyeball which serves to refract light." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0001911 is_a: UBERON:0000463 ! organism substance relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye [Term] id: UBERON:0006314 name: bodily fluid +def: "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not." [MESH:A12.207, Wikipedia:Body_fluid] +xref: BIRNLEX:20 +xref: FMA:280556 +xref: GAID:266 +xref: galen:BodyFluid +xref: MESH:D001826 +xref: Wikipedia:Body_fluid is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0000086 PATO:0001548 @@ -40264,6 +61327,9 @@ relationship: RO:0000086 PATO:0001548 [Term] id: UBERON:0006331 name: brainstem nucleus +def: "A nucleus of brain that is part of a brainstem." [OBOL:automatic] +xref: EMAPA:32790 +xref: MA:0000821 is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0002298 ! part of brainstem @@ -40272,6 +61338,11 @@ relationship: BFO:0000050 UBERON:0002298 ! part of brainstem [Term] id: UBERON:0006347 name: communicating artery +def: "An artery that connects two larger arteries." [ncithesaurus:Communicating_Artery] +comment: Grouping for anterior and posterior +xref: EMAPA:18598 +xref: MA:0001938 +xref: NCIT:C52851 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002176 UBERON:0001637 {cardinality="2"} ! artery @@ -40280,6 +61351,11 @@ relationship: RO:0002176 UBERON:0001637 ! artery [Term] id: UBERON:0006518 name: right lung lobe +def: "A lobe of lung that is part of a right lung." [OBOL:automatic] +xref: EMAPA:35155 +xref: MA:0001791 +xref: NCIT:C48944 +xref: SCTID:272654004 is_a: UBERON:0000101 ! lobe of lung intersection_of: UBERON:0000101 ! lobe of lung intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -40288,6 +61364,11 @@ relationship: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0006524 name: alveolar system +def: "System pertaining to a bronchus and alveoli." [BTO:0000136] +xref: BTO:0000136 +xref: CALOHA:TS-1296 +xref: EMAPA:32692 +xref: MA:0000416 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002048 ! part of lung @@ -40296,6 +61377,8 @@ relationship: RO:0002433 UBERON:0002048 ! lung [Term] id: UBERON:0006525 name: left lung alveolar system +xref: EMAPA:19001 +xref: MA:0001775 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002168 ! part of left lung @@ -40304,6 +61387,8 @@ relationship: BFO:0000050 UBERON:0006524 ! part of alveolar system [Term] id: UBERON:0006526 name: right lung alveolar system +xref: EMAPA:35717 +xref: MA:0001784 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0002167 ! part of right lung @@ -40312,6 +61397,8 @@ relationship: BFO:0000050 UBERON:0006524 ! part of alveolar system [Term] id: UBERON:0006535 name: skin secretion +def: "A portion of organism substance that secreted_by a zone of skin." [OBOL:automatic] +xref: MA:0002537 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0000014 ! produced by zone of skin @@ -40320,6 +61407,8 @@ relationship: RO:0003001 UBERON:0000014 ! produced by zone of skin [Term] id: UBERON:0006537 name: female reproductive gland secretion +def: "A portion of organism substance that is secreted by a female reproductive gland." [UBERON:cjm] +xref: MA:0002510 is_a: UBERON:0022293 ! reproductive gland secretion intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0005398 ! produced by female reproductive gland @@ -40328,20 +61417,39 @@ relationship: RO:0003001 UBERON:0005398 ! produced by female reproductive gland [Term] id: UBERON:0006538 name: respiratory system fluid/secretion +def: "A portion of organism substance that secreted_by a respiratory system." [OBOL:automatic] +xref: EMAPA:36550 +xref: MA:0002533 +xref: NCIT:C13722 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0001004 ! produced by respiratory system relationship: RO:0003001 UBERON:0001004 ! produced by respiratory system +[Term] +id: UBERON:0006555 +name: excretory tube +def: "A tube that is part of a excretory system." [OBOL:automatic] +is_a: UBERON:0000025 ! tube +intersection_of: UBERON:0000025 ! tube +intersection_of: BFO:0000050 UBERON:0001008 ! part of renal system +relationship: BFO:0000050 UBERON:0001008 ! part of renal system + [Term] id: UBERON:0006562 name: pharynx +def: "The pharynx is the part of the digestive system immediately posterior to the mouth[GO]." [GO:0060465] +xref: MAT:0000049 +xref: MESH:D010614 +xref: MIAA:0000049 is_a: UBERON:0004921 ! subdivision of digestive tract relationship: RO:0002160 NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0006563 name: tunica media of pulmonary trunk +def: "Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA]." [FMA:85030, FMA:FMA] +xref: FMA:85030 is_a: UBERON:0007239 ! tunica media of artery intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0002333 ! part of pulmonary trunk @@ -40350,26 +61458,77 @@ relationship: BFO:0000050 UBERON:0002333 ! part of pulmonary trunk [Term] id: UBERON:0006566 name: left ventricle myocardium +def: "A myocardium that is part of a left ventricle of a heart." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:9558 +xref: MA:0002983 +xref: SCTID:362021000 is_a: UBERON:0001083 ! myocardium of ventricle intersection_of: UBERON:0001083 ! myocardium of ventricle intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle relationship: RO:0002150 UBERON:0003618 ! aorta tunica media -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006567 name: right ventricle myocardium +def: "A myocardium that is part of a right ventricle of a heart." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:9535 +xref: MA:0002984 +xref: SCTID:362020004 is_a: UBERON:0001083 ! myocardium of ventricle intersection_of: UBERON:0001083 ! myocardium of ventricle intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle relationship: RO:0002150 UBERON:0006563 ! tunica media of pulmonary trunk -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0006570 +name: trabecula carnea of right ventricle +def: "A trabecula carnea that is part of a heart right ventricle." [OBOL:automatic] +xref: FMA:7270 +xref: SCTID:192373001 +is_a: UBERON:0002511 ! trabecula carnea +intersection_of: UBERON:0002511 ! trabecula carnea +intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle +relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle + +[Term] +id: UBERON:0006571 +name: trabecula carnea of left ventricle +def: "A trabecula carnea that is part of a heart left ventricle." [OBOL:automatic] +xref: FMA:7271 +xref: SCTID:190344008 +is_a: UBERON:0002511 ! trabecula carnea +intersection_of: UBERON:0002511 ! trabecula carnea +intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle +relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle + +[Term] +id: UBERON:0006574 +name: pectinate line +def: "The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:." [Wikipedia:Pectinate_line] +xref: EMAPA:19159 +xref: FMA:75383 +xref: NCIT:C34245 +xref: SCTID:245445008 +xref: Wikipedia:Pectinate_line +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:8410024 ! intestinal junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0000931 ! proctodeum +intersection_of: RO:0002176 UBERON:0001046 ! hindgut +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: RO:0002176 UBERON:0000931 ! proctodeum +relationship: RO:0002176 UBERON:0001046 ! hindgut [Term] id: UBERON:0006595 name: presumptive endoderm +def: "Presumptive structure of the blastula that will develop into endoderm." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000471 +xref: EFO:0003437 +xref: TAO:0000416 +xref: ZFA:0000416 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: BFO:0000050 UBERON:0000307 ! part of blastula @@ -40381,6 +61540,10 @@ relationship: RO:0002387 UBERON:0000925 ! endoderm [Term] id: UBERON:0006596 name: presumptive blood +xref: AAO:0000468 +xref: EFO:0003439 +xref: TAO:0000568 +xref: ZFA:0000568 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0000178 ! blood @@ -40389,6 +61552,10 @@ relationship: RO:0002387 UBERON:0000178 ! blood [Term] id: UBERON:0006598 name: presumptive structure +def: "Portion of embryonic tissue determined by fate mapping to become a structure." [GOC:CVS, GOC:YMB, ZFA:0001116] +xref: AAO:0000479 +xref: TAO:0001116 +xref: ZFA:0001116 is_a: UBERON:0002050 ! embryonic structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -40398,6 +61565,12 @@ relationship: RO:0002387 UBERON:0000061 ! anatomical structure [Term] id: UBERON:0006601 name: presumptive ectoderm +def: "Presumptive structure of the blastula that will develop into ectoderm." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000470 +xref: EFO:0003466 +xref: TAO:0001376 +xref: XAO:0004132 +xref: ZFA:0001376 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: BFO:0000050 UBERON:0000307 ! part of blastula @@ -40409,6 +61582,11 @@ relationship: RO:0002387 UBERON:0000924 ! ectoderm [Term] id: UBERON:0006603 name: presumptive mesoderm +def: "Presumptive structure of the blastula that will develop into mesoderm." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000476 +xref: EFO:0003467 +xref: TAO:0001377 +xref: ZFA:0001377 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: BFO:0000050 UBERON:0000307 ! part of blastula @@ -40417,9 +61595,27 @@ relationship: BFO:0000050 UBERON:0000307 ! part of blastula relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa relationship: RO:0002387 UBERON:0000926 ! mesoderm +[Term] +id: UBERON:0006660 +name: muscular coat +def: "A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis." [Wikipedia:Muscular_layer] +xref: BTO:0004838 +xref: SCTID:86915006 +xref: Wikipedia:Muscular_layer +is_a: UBERON:0018260 ! layer of muscle tissue +relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata +relationship: RO:0002220 UBERON:0000009 ! adjacent to submucosa + [Term] id: UBERON:0006670 name: central tendon of diaphragm +def: "The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers." [MGI:csmith, MP:0012061] +xref: EMAPA:17702 +xref: FMA:58279 +xref: NCIT:C34119 +xref: SCTID:244943002 +xref: VHOG:0001399 +xref: Wikipedia:Central_tendon_of_diaphragm is_a: UBERON:0000043 ! tendon is_a: UBERON:0003570 ! respiratory system connective tissue is_a: UBERON:0003837 ! thoracic segment connective tissue @@ -40430,14 +61626,39 @@ relationship: RO:0002495 UBERON:0006239 ! future central tendon [Term] id: UBERON:0006677 name: surface of epithelium +def: "An anatomical boundary that adjacent_to a epithelium." [OBOL:automatic] +xref: FMA:70997 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: RO:0002007 UBERON:0000483 ! bounding layer of epithelium relationship: RO:0002007 UBERON:0000483 ! bounding layer of epithelium +[Term] +id: UBERON:0006686 +name: spinal vein +def: "A vein that is part of a vertebral column." [OBOL:automatic] +xref: EMAPA:18255 +xref: FMA:76735 +xref: MA:0002108 +xref: SCTID:181376008 +xref: Wikipedia:Spinal_veins +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: BFO:0000050 UBERON:0001130 ! part of vertebral column +relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column + [Term] id: UBERON:0006761 name: corneo-scleral junction +def: "The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm." [MP:0013477] +comment: This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343 +xref: EFO:0001403 +xref: FMA:58342 +xref: GAID:896 +xref: MESH:D016850 +xref: SCTID:63716004 +xref: Wikipedia:Corneal_limbus +xref: ZFA:0005570 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction @@ -40446,11 +61667,14 @@ intersection_of: RO:0002176 UBERON:0001773 ! sclera relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye relationship: RO:0002176 UBERON:0000964 ! cornea relationship: RO:0002176 UBERON:0001773 ! sclera -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006799 name: glandular epithelium +def: "An epithelium that is composed primarily of secretory cells." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0002991 +xref: NCIT:C43370 +xref: NCIT:C45715 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002473 CL:0000150 ! glandular epithelial cell @@ -40459,14 +61683,30 @@ relationship: RO:0002473 CL:0000150 ! glandular epithelial cell [Term] id: UBERON:0006815 name: areolar connective tissue +def: "Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand." [FMA:63897] +xref: AAO:0000027 +xref: FMA:63897 +xref: SCTID:68477002 is_a: UBERON:0011825 ! loose connective tissue relationship: BFO:0000050 UBERON:0000030 ! part of lamina propria relationship: BFO:0000051 CL:1000303 ! has part fibroblast of areolar connective tissue relationship: protects UBERON:0000062 ! organ +[Term] +id: UBERON:0006828 +name: trabecula carnea of atrium +def: "The supporting bundles of muscular fibers lining the walls of the atria[MP]." [MP:0010581] +is_a: UBERON:0002511 ! trabecula carnea +intersection_of: UBERON:0002511 ! trabecula carnea +intersection_of: BFO:0000050 UBERON:0002081 ! part of cardiac atrium +relationship: BFO:0000050 UBERON:0002081 ! part of cardiac atrium + [Term] id: UBERON:0006833 name: lumen of trachea +def: "An anatomical space that surrounded_by a trachea." [OBOL:automatic] +xref: FMA:7469 +xref: SCTID:197486000 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0003126 ! trachea @@ -40476,6 +61716,9 @@ relationship: RO:0002572 UBERON:0003126 ! trachea [Term] id: UBERON:0006834 name: uterus or analog +def: "A subdivision of a the reproductive tract in a female organism that is the site of embryo development." [http://orcid.org/0000-0002-6601-2165] +xref: TADS:0000421 +xref: WBbt:0006760 is_a: UBERON:0005156 ! reproductive structure is_a: UBERON:0013522 ! subdivision of tube intersection_of: UBERON:0013522 ! subdivision of tube @@ -40484,23 +61727,78 @@ relationship: BFO:0000050 UBERON:0000474 ! part of female reproductive system relationship: RO:0002160 NCBITaxon:33208 ! Metazoa relationship: site_of GO:0009790 ! embryo development +[Term] +id: UBERON:0006841 +name: central vein of liver +def: "Vein that is central to a lobule in the liver." [ZFA:0005168] +xref: FMA:17544 +xref: NCIT:C32281 +xref: SCTID:272023004 +xref: TAO:0005168 +xref: Wikipedia:Central_veins_of_liver +xref: ZFA:0005168 +is_a: UBERON:0013126 ! vein of abdomen +is_a: UBERON:0015796 ! liver blood vessel +relationship: BFO:0000050 UBERON:0004647 ! part of liver lobule + [Term] id: UBERON:0006846 name: surface groove +def: "A furrow or an incomplete tube." [AEO:0000161, AEO:JB, https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/4] +comment: Surface groove is modelled as immaterial - see https://github.com/obophenotype/uberon/issues/2667 for discussion +xref: AEO:0000161 +xref: EHDAA2_RETIRED:0003161 is_a: UBERON:0000466 ! immaterial anatomical entity relationship: RO:0000086 PATO:0002255 +[Term] +id: UBERON:0006866 +name: terminal part of digestive tract +def: "The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus." [http://orcid.org/0000-0002-6601-2165] +xref: WBbt:0005773 +is_a: UBERON:0004921 ! subdivision of digestive tract +relationship: RO:0002150 UBERON:0001245 ! anus +relationship: RO:0002202 UBERON:0001046 ! hindgut + [Term] id: UBERON:0006876 name: vasculature of organ +def: "A vasculature that is part of a organ." [OBOL:automatic] +xref: FMA:74612 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000062 ! part of organ relationship: BFO:0000050 UBERON:0000062 ! part of organ +[Term] +id: UBERON:0006877 +name: vasculature of liver +def: "A vasculature that is part of a liver." [OBOL:automatic] +xref: EHDAA2:0003454 +xref: EMAPA:35501 +xref: FMA:73748 +is_a: UBERON:0002201 ! vasculature of trunk +is_a: UBERON:0006876 ! vasculature of organ +intersection_of: UBERON:0002049 ! vasculature +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: UBERON:0006904 name: head mesenchyme from mesoderm +def: "A head mesenchyme that develops_from a mesoderm." [OBOL:automatic] +xref: AAO:0011051 +xref: EFO:0003337 +xref: EFO:0003603 +xref: EHDAA2:0001118 +xref: EHDAA:655 +xref: EMAPA:16099 +xref: EMAPA_RETIRED:16270 +xref: FMA:293859 +xref: TAO:0000998 +xref: VHOG:0000185 +xref: XAO:0000053 +xref: ZFA:0000998 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005253 ! head mesenchyme intersection_of: UBERON:0005253 ! head mesenchyme @@ -40510,6 +61808,11 @@ relationship: RO:0002202 UBERON:0003063 ! prechordal plate [Term] id: UBERON:0006905 name: mandibular process mesenchyme +def: "Mesenchyme that is part of a mandibular prominence." [OBOL:automatic] +xref: EHDAA2:0001062 +xref: EHDAA:5861 +xref: EHDAA:5873 +xref: EMAPA:17357 is_a: UBERON:0005253 ! head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0005867 ! part of mandibular prominence @@ -40518,6 +61821,10 @@ relationship: BFO:0000050 UBERON:0005867 ! part of mandibular prominence [Term] id: UBERON:0006909 name: lumen of digestive tract +def: "An anatomical space that surrounded_by a digestive tract." [OBOL:automatic] +xref: BTO:0000349 +xref: EMAPA:32908 +xref: FMA:45677 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001555 ! digestive tract @@ -40527,6 +61834,10 @@ relationship: RO:0002572 UBERON:0001555 ! digestive tract [Term] id: UBERON:0006913 name: lip epithelium +def: "An epithelium that is part of a lip." [OBOL:automatic] +xref: BTO:0004468 +xref: TAO:0005334 +xref: ZFA:0005334 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001833 ! part of lip @@ -40535,6 +61846,11 @@ relationship: BFO:0000050 UBERON:0001833 ! part of lip [Term] id: UBERON:0006914 name: squamous epithelium +def: "An epithelium characterised by its most superficial layer consisting of squamous epithelial cells." [Wikipedia:Squamous_epithelium] +xref: BTO:0002072 +xref: NCIT:C12848 +xref: SCTID:40118003 +xref: Wikipedia:Squamous_epithelium is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000051 CL:0000076 ! has part squamous epithelial cell @@ -40543,6 +61859,10 @@ relationship: BFO:0000051 CL:0000076 ! has part squamous epithelial cell [Term] id: UBERON:0006915 name: stratified squamous epithelium +def: "Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]." [FMA:45563, Wikipedia:Stratified_squamous_epithelium] +xref: FMA:45563 +xref: NCIT:C13180 +xref: Wikipedia:Stratified_squamous_epithelium is_a: UBERON:0000486 ! multilaminar epithelium is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0000486 ! multilaminar epithelium @@ -40551,6 +61871,12 @@ intersection_of: BFO:0000051 CL:0000076 ! has part squamous epithelial cell [Term] id: UBERON:0006920 name: esophagus squamous epithelium +def: "A squamous epithelium that is part of a esophagus." [OBOL:automatic] +xref: BTO:0003635 +xref: CALOHA:TS-1250 +xref: EMAPA:35324 +xref: MA:0001567 +xref: NCIT:C49222 is_a: UBERON:0001976 ! epithelium of esophagus is_a: UBERON:0006914 ! squamous epithelium intersection_of: UBERON:0006914 ! squamous epithelium @@ -40559,6 +61885,9 @@ intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus [Term] id: UBERON:0006921 name: stomach squamous epithelium +def: "A squamous epithelium that is part of a stomach." [OBOL:automatic] +xref: EMAPA:35824 +xref: MA:0001611 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0001276 ! epithelium of stomach intersection_of: UBERON:0006914 ! squamous epithelium @@ -40567,6 +61896,10 @@ intersection_of: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: UBERON:0006924 name: stomach glandular epithelium +def: "A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands." [ISBN:0073040584] +xref: EMAPA:35814 +xref: FMA:63458 +xref: MA:0002784 is_a: UBERON:0001276 ! epithelium of stomach is_a: UBERON:0006929 ! glandular columnar epithelium intersection_of: UBERON:0006799 ! glandular epithelium @@ -40577,6 +61910,9 @@ relationship: BFO:0000051 UBERON:0000325 ! has part gastric gland [Term] id: UBERON:0006925 name: digestive system gland +def: "Any gland that is part of the digestive system." [UBERON:cjm] +xref: AAO:0000130 +xref: BTO:0000345 is_a: UBERON:0002368 ! endocrine gland is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0002368 ! endocrine gland @@ -40585,6 +61921,9 @@ intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system [Term] id: UBERON:0006929 name: glandular columnar epithelium +def: "Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]." [FMA:64800] +xref: FMA:64800 +xref: NCIT:C13182 is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0006799 ! glandular epithelium intersection_of: UBERON:0000485 ! simple columnar epithelium @@ -40593,6 +61932,7 @@ intersection_of: RO:0002473 CL:0000150 ! glandular epithelial cell [Term] id: UBERON:0006930 name: glandular cuboidal epithelium +xref: FMA:66809 is_a: UBERON:0000484 ! simple cuboidal epithelium is_a: UBERON:0006799 ! glandular epithelium intersection_of: UBERON:0000484 ! simple cuboidal epithelium @@ -40601,6 +61941,9 @@ intersection_of: RO:0002473 CL:0000150 ! glandular epithelial cell [Term] id: UBERON:0006931 name: stomach glandular region mucosa +def: "Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:27167 +xref: MA:0001614 is_a: UBERON:0001199 ! mucosa of stomach intersection_of: UBERON:0001199 ! mucosa of stomach intersection_of: BFO:0000050 UBERON:0011953 ! part of stomach glandular region @@ -40609,6 +61952,10 @@ relationship: BFO:0000050 UBERON:0011953 ! part of stomach glandular region [Term] id: UBERON:0006934 name: sensory epithelium +def: "Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue." [BTO:0000314] +xref: CALOHA:TS-0682 +xref: FMA:62410 +xref: SCTID:309045006 is_a: UBERON:0000488 ! atypical epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000051 CL:0000098 ! has part sensory epithelial cell @@ -40618,17 +61965,28 @@ relationship: BFO:0000051 CL:0000098 ! has part sensory epithelial cell [Term] id: UBERON:0006960 name: ovary stroma +def: "The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis." [Wikipedia:Stroma_of_ovary] +xref: CALOHA:TS-1246 +xref: EMAPA:28880 +xref: FMA:18626 +xref: MA:0002991 +xref: NCIT:C33638 +xref: SCTID:259306002 +xref: Wikipedia:Stroma_of_ovary is_a: UBERON:0003891 ! stroma is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0003891 ! stroma intersection_of: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000050 UBERON:0000992 ! part of ovary relationship: BFO:0000051 CL:0002095 ! has part hilus cell of ovary -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0006965 name: vascular cord +def: "The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]." [GO:0072360, ZFA:0005077] +xref: EFO:0003709 +xref: TAO:0005077 +xref: ZFA:0005077 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0014903 ! part of primordial vasculature relationship: BFO:0000051 CL:0000115 ! has part endothelial cell @@ -40638,6 +61996,8 @@ relationship: site_of GO:0048754 ! branching morphogenesis of an epithelial tube [Term] id: UBERON:0006966 name: coronary capillary +def: "A capillary that is part of the coronary system." [http://orcid.org/0000-0002-6601-2165] +xref: ZFA:0005813 is_a: UBERON:0001982 ! capillary is_a: UBERON:0003498 ! heart blood vessel intersection_of: UBERON:0001982 ! capillary @@ -40646,11 +62006,28 @@ intersection_of: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: UBERON:0006984 name: anatomical surface +def: "A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n." [CARO:0001002] +comment: Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism. +xref: BILA:0000010 +xref: CARO:0001002 +xref: EHDAA2_RETIRED:0003192 +xref: FMA:24137 +xref: NCIT:C34022 is_a: UBERON:0010199 ! bona-fide anatomical boundary [Term] id: UBERON:0007005 name: cardiogenic splanchnic mesoderm +def: "The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]." [http://www.drugs.com/dict/cardiogenic-mesoderm.html, https://github.com/obophenotype/insect_neuroanatomy_ontology/issues/7, XAO:0000235] +xref: AAO:0011021 +xref: BILA:0000051 +xref: EFO:0000315 +xref: EHDAA2:0000214 +xref: EHDAA:385 +xref: FMA:293143 +xref: SCTID:360387000 +xref: VHOG:0001641 +xref: XAO:0000235 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0004140 ! part of primary heart field @@ -40661,6 +62038,8 @@ relationship: RO:0002256 UBERON:0009881 ! anterior lateral plate mesoderm [Term] id: UBERON:0007010 name: cleaving embryo +def: "Organism at the cleavage stage." [OBOL:automatic] +xref: BILA:0000058 is_a: UBERON:0000922 ! embryo intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002489 UBERON:0000107 ! cleavage stage @@ -40671,6 +62050,9 @@ relationship: RO:0002493 UBERON:0000107 ! cleavage stage [Term] id: UBERON:0007026 name: presumptive gut +xref: BILA:0000084 +xref: NCIT:C34268 +xref: SCTID:360394002 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001555 ! digestive tract @@ -40682,6 +62064,7 @@ relationship: RO:0002488 UBERON:0000109 ! gastrula stage [Term] id: UBERON:0007037 name: mechanosensory system +xref: BILA:0000142 is_a: UBERON:0001032 ! sensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: RO:0002215 GO:0050954 ! capable of sensory perception of mechanical stimulus @@ -40690,12 +62073,20 @@ relationship: RO:0002215 GO:0050954 ! capable of sensory perception of mechanica [Term] id: UBERON:0007098 name: mandibular neural crest +def: "Cranial neural crest that migrates into the mandibular arch." [ZFA:0007064] +xref: TAO:0007064 +xref: XAO:0000024 +xref: ZFA:0007064 is_a: UBERON:0003099 ! cranial neural crest relationship: BFO:0000050 UBERON:0003852 ! part of rhombencephalon neural crest [Term] id: UBERON:0007100 name: primary circulatory organ +def: "A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]." [GO:0007507] +comment: Gene notes: Bmp, Nkx, Gata +xref: http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg +xref: TADS:0000147 is_a: UBERON:0015228 ! circulatory organ intersection_of: UBERON:0015228 ! circulatory organ intersection_of: RO:0002215 GO:0008015 ! capable of blood circulation @@ -40705,6 +62096,12 @@ relationship: RO:0002215 GO:0008015 ! capable of blood circulation [Term] id: UBERON:0007134 name: trunk ganglion +def: "Ganglion which is located in the trunk." [ZFIN:curator] +xref: EFO:0000901 +xref: MAT:0000344 +xref: MIAA:0000344 +xref: TAO:0001573 +xref: ZFA:0001573 is_a: UBERON:0000045 ! ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk @@ -40713,12 +62110,92 @@ relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0007135 name: neural keel +def: "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section." [ZFIN:ZDB-PUB-961014-576] +xref: EFO:0003497 +xref: TAO:0000131 +xref: ZFA:0000131 is_a: UBERON:0016879 ! future central nervous system relationship: RO:0002202 UBERON:0003075 ! neural plate +[Term] +id: UBERON:0007144 +name: embryonic post-anal tail +def: "An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:16748 +xref: FMA:85540 +is_a: UBERON:0002050 ! embryonic structure +relationship: RO:0002494 UBERON:0002533 ! post-anal tail bud + +[Term] +id: UBERON:0007147 +name: lumen of midgut +def: "An anatomical cavity that surrounded_by a midgut." [OBOL:automatic] +xref: EMAPA:18377 +xref: FMA:54366 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0001045 ! midgut +relationship: BFO:0000050 UBERON:0001045 ! part of midgut +relationship: RO:0002572 UBERON:0001045 ! midgut + +[Term] +id: UBERON:0007148 +name: lumen of hindgut +def: "An anatomical cavity that surrounded_by a hindgut." [OBOL:automatic] +xref: EMAPA:18396 +xref: FMA:54367 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0001046 ! hindgut +relationship: BFO:0000050 UBERON:0001046 ! part of hindgut +relationship: RO:0002572 UBERON:0001046 ! hindgut + +[Term] +id: UBERON:0007158 +name: lumen of anal canal +def: "An anatomical cavity that surrounded_by a anal canal." [OBOL:automatic] +xref: EMAPA:18836 +xref: FMA:17357 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0000159 ! anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: RO:0002572 UBERON:0000159 ! anal canal + +[Term] +id: UBERON:0007159 +name: lumen of colon +def: "An anatomical cavity that surrounded_by a colon." [OBOL:automatic] +xref: EMAPA:18945 +xref: FMA:18374 +xref: SCTID:362156004 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0001155 ! colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon +relationship: RO:0002572 UBERON:0001155 ! colon + +[Term] +id: UBERON:0007177 +name: lamina propria of mucosa of colon +def: "A lamina propria that is part of a colonic mucosa." [OBOL:automatic] +xref: EMAPA:27395 +xref: FMA:15657 +xref: MA:0003196 +xref: SCTID:113284008 +is_a: UBERON:0011189 ! lamina propria of large intestine +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: BFO:0000050 UBERON:0000317 ! part of colonic mucosa +relationship: BFO:0000050 UBERON:0000317 ! part of colonic mucosa + [Term] id: UBERON:0007188 name: mesothelium of serous pericardium +def: "A mesothelium that is part of a serous pericardium." [OBOL:automatic] +xref: BTO:0003157 +xref: EMAPA:16133 +xref: FMA:18149 +xref: SCTID:67300002 is_a: UBERON:0003388 ! mesothelium of pericardial cavity intersection_of: UBERON:0001136 ! mesothelium intersection_of: BFO:0000050 UBERON:0002357 ! part of serous pericardium @@ -40727,6 +62204,10 @@ relationship: BFO:0000050 UBERON:0002357 ! part of serous pericardium [Term] id: UBERON:0007195 name: stroma of bone marrow +def: "The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis." [Wikipedia:Bone_marrow#Stroma] +xref: CALOHA:TS-0085 +xref: FMA:21426 +xref: Wikipedia:Bone_marrow#Stroma is_a: UBERON:0003891 ! stroma is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003891 ! stroma @@ -40739,22 +62220,35 @@ relationship: BFO:0000051 UBERON:0003909 ! has part sinusoid [Term] id: UBERON:0007196 name: tracheobronchial tree +def: "The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells." [Wikipedia:Tracheobronchial_tree] +xref: FMA:7393 +xref: NCIT:C117875 +xref: SCTID:361384001 +xref: Wikipedia:Tracheobronchial_tree is_a: UBERON:0000062 ! organ is_a: UBERON:0004119 ! endoderm-derived structure relationship: BFO:0000050 UBERON:0001558 ! part of lower respiratory tract relationship: BFO:0000051 UBERON:0002185 ! has part bronchus relationship: BFO:0000051 UBERON:0003126 ! has part trachea relationship: BFO:0000051 UBERON:0007592 ! has part ciliated columnar epithelium -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007204 name: brachiocephalic vasculature +def: "The vasculature consisting of brachiocephalic arteries and veins." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002049 ! vasculature [Term] id: UBERON:0007213 name: mesenchyme derived from head neural crest +def: "Mesenchyme that develops_from a cranial neural crest." [OBOL:automatic] +xref: EFO:0003572 +xref: EHDAA2:0000735 +xref: EMAPA:16169 +xref: EMAPA:16271 +xref: EMAPA_RETIRED:16271 +xref: TAO:0000787 +xref: ZFA:0000787 is_a: UBERON:0005253 ! head mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest intersection_of: UBERON:0003104 ! mesenchyme @@ -40764,6 +62258,11 @@ relationship: RO:0002202 UBERON:0003099 ! cranial neural crest [Term] id: UBERON:0007214 name: mesenchyme derived from trunk neural crest +def: "Mesenchyme that develops_from a trunk neural crest." [OBOL:automatic] +xref: EHDAA2:0002093 +xref: EMAPA:16182 +xref: TAO:0000999 +xref: ZFA:0000999 is_a: UBERON:0005256 ! trunk mesenchyme is_a: UBERON:0014387 ! mesenchyme derived from neural crest intersection_of: UBERON:0003104 ! mesenchyme @@ -40773,12 +62272,31 @@ relationship: RO:0002202 UBERON:0003083 ! trunk neural crest [Term] id: UBERON:0007237 name: 1st arch mandibular component +xref: EHDAA2:0000031 +xref: EHDAA:583 +xref: EMAPA:16382 +xref: VHOG:0000510 +is_a: UBERON:0002050 ! embryonic structure +relationship: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 + +[Term] +id: UBERON:0007238 +name: 1st arch maxillary component +xref: EHDAA2:0000038 +xref: EHDAA:595 +xref: EMAPA:16388 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 [Term] id: UBERON:0007239 name: tunica media of artery +def: "A tunica media that is part of a artery." [OBOL:automatic] +xref: EMAPA:36294 +xref: EV:0100029 +xref: FMA:14273 +xref: NCIT:C49321 +xref: SCTID:84300001 is_a: UBERON:0002522 ! tunica media intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0001637 ! part of artery @@ -40787,6 +62305,11 @@ relationship: BFO:0000050 UBERON:0000415 ! part of artery wall [Term] id: UBERON:0007240 name: tunica adventitia of artery +def: "A tunica adventitia that is part of a artery." [OBOL:automatic] +xref: EMAPA:36295 +xref: EV:0100030 +xref: FMA:14274 +xref: SCTID:113261001 is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: BFO:0000050 UBERON:0001637 ! part of artery @@ -40796,6 +62319,11 @@ relationship: BFO:0000051 CL:1000306 ! has part fibroblast of tunica adventitia [Term] id: UBERON:0007241 name: tunica adventitia of vein +def: "A tunica adventitia that is part of a vein." [OBOL:automatic] +xref: EMAPA:36310 +xref: EV:0100034 +xref: FMA:14355 +xref: SCTID:13202006 is_a: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel intersection_of: BFO:0000050 UBERON:0001638 ! part of vein @@ -40804,6 +62332,11 @@ relationship: BFO:0000050 UBERON:0001638 ! part of vein [Term] id: UBERON:0007242 name: tunica intima of vein +def: "A tunica intima that is part of a vein." [OBOL:automatic] +xref: EMAPA:36308 +xref: EV:0100032 +xref: FMA:14353 +xref: SCTID:2436009 is_a: UBERON:0002523 ! tunica intima is_a: UBERON:0004797 ! blood vessel layer intersection_of: UBERON:0002523 ! tunica intima @@ -40813,6 +62346,11 @@ relationship: BFO:0000050 UBERON:0001638 ! part of vein [Term] id: UBERON:0007243 name: tunica media of vein +def: "A tunica media that is part of a vein." [OBOL:automatic] +xref: EMAPA:36309 +xref: EV:0100033 +xref: FMA:14354 +xref: SCTID:42049001 is_a: UBERON:0002522 ! tunica media intersection_of: UBERON:0002522 ! tunica media intersection_of: BFO:0000050 UBERON:0001638 ! part of vein @@ -40821,6 +62359,9 @@ relationship: BFO:0000050 UBERON:0001638 ! part of vein [Term] id: UBERON:0007245 name: nuclear complex of neuraxis +def: "Gray matter of the central nervous system which is a collection of clustered nuclei." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:256381 +xref: FMA:84059 is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: RO:0002473 UBERON:0000125 ! neural nucleus @@ -40829,6 +62370,9 @@ relationship: RO:0002473 UBERON:0000125 ! neural nucleus [Term] id: UBERON:0007247 name: nucleus of superior olivary complex +def: "Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:72246 +xref: SCTID:369024009 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus intersection_of: UBERON:0002308 ! nucleus of brain @@ -40838,6 +62382,9 @@ relationship: BFO:0000050 UBERON:0002128 ! part of superior olivary complex [Term] id: UBERON:0007267 name: trachea pre-cartilage rings +def: "A pre-cartilage condensation that is part of a trachea." [OBOL:automatic] +xref: EHDAA2:0002070 +xref: EHDAA:7082 is_a: UBERON:0005866 ! pre-cartilage condensation is_a: UBERON:0009505 ! mesenchyme of trachea intersection_of: UBERON:0005866 ! pre-cartilage condensation @@ -40847,6 +62394,10 @@ relationship: RO:0002202 UBERON:0009505 ! mesenchyme of trachea [Term] id: UBERON:0007269 name: pectoral appendage musculature +def: "Any collection of muscles that is part of a pectoral appendage." [OBOL:automatic] +xref: EFO:0003540 +xref: TAO:0000563 +xref: ZFA:0000563 is_a: UBERON:0007271 ! appendage musculature is_a: UBERON:0014793 ! musculature of pectoral complex intersection_of: UBERON:0001015 ! musculature @@ -40856,6 +62407,9 @@ relationship: BFO:0000050 UBERON:0004710 ! part of pectoral appendage [Term] id: UBERON:0007271 name: appendage musculature +def: "Any collection of muscles that is part of an appendage." [OBOL:automatic] +xref: TAO:0000207 +xref: ZFA:0000207 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0000026 ! part of appendage @@ -40864,6 +62418,8 @@ relationship: BFO:0000050 UBERON:0000026 ! part of appendage [Term] id: UBERON:0007272 name: pectoral appendage skeleton +def: "Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle." [VSAO:0005000, VSAO:NI] +xref: VSAO:0005000 is_a: UBERON:0011582 ! paired limb/fin skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0004710 ! pectoral appendage @@ -40874,6 +62430,15 @@ relationship: RO:0002576 UBERON:0004710 ! pectoral appendage [Term] id: UBERON:0007277 name: presumptive hindbrain +def: "The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure." [Wikipedia:Rhombencephalon] +xref: BAMS:HB +xref: CALOHA:TS-2118 +xref: EFO:0003440 +xref: EHDAA2:0001630 +xref: FMA:295640 +xref: TAO:0000569 +xref: Wikipedia:Rhombencephalon +xref: ZFA:0000569 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002028 ! hindbrain @@ -40885,6 +62450,9 @@ relationship: RO:0002387 UBERON:0002028 ! hindbrain [Term] id: UBERON:0007278 name: presumptive sinus venosus +def: "Portion of tissue that is part of the heart tube and will become the sinus venosus." [ZFA:0001722] +xref: TAO:0002234 +xref: ZFA:0001722 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002063 ! sinus venosus @@ -40894,6 +62462,9 @@ relationship: RO:0002387 UBERON:0002063 ! sinus venosus [Term] id: UBERON:0007280 name: presumptive endocardium +def: "A presumptive structure that has the potential to develop into a endocardium." [OBOL:automatic] +xref: TAO:0002233 +xref: ZFA:0001724 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0002165 ! endocardium @@ -40904,6 +62475,11 @@ relationship: RO:0002387 UBERON:0002165 ! endocardium [Term] id: UBERON:0007281 name: presumptive midbrain hindbrain boundary +def: "Embryonic structure that gives rise to the midbrain hindbrain boundary." [ZFA:0001187] +xref: EFO:0003446 +xref: TAO:0001187 +xref: XAO:0004086 +xref: ZFA:0001187 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003052 ! midbrain-hindbrain boundary @@ -40913,6 +62489,10 @@ relationship: RO:0002387 UBERON:0003052 ! midbrain-hindbrain boundary [Term] id: UBERON:0007282 name: presumptive segmental plate +def: "A presumptive structure that has the potential to develop into a presomitic mesoderm." [OBOL:automatic] +xref: EFO:0003421 +xref: TAO:0000053 +xref: ZFA:0000053 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003059 ! presomitic mesoderm @@ -40922,6 +62502,10 @@ relationship: RO:0002387 UBERON:0003059 ! presomitic mesoderm [Term] id: UBERON:0007284 name: presumptive neural plate +def: "A presumptive structure that has the potential to develop into a neural plate." [OBOL:automatic] +xref: EFO:0003424 +xref: TAO:0000063 +xref: ZFA:0000063 is_a: UBERON:0016879 ! future central nervous system intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0003075 ! neural plate @@ -40932,6 +62516,11 @@ relationship: RO:0002387 UBERON:0003075 ! neural plate [Term] id: UBERON:0007285 name: presumptive paraxial mesoderm +def: "The part of the blastula that has the potential to develop into a paraxial mesoderm." [https://github.com/obophenotype/uberon/issues/1277, UBERON:cjm] +xref: EFO:0003443 +xref: TAO:0000591 +xref: XAO:0004134 +xref: ZFA:0000591 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0000307 ! part of blastula relationship: RO:0002387 UBERON:0003077 ! paraxial mesoderm @@ -40939,6 +62528,9 @@ relationship: RO:0002387 UBERON:0003077 ! paraxial mesoderm [Term] id: UBERON:0007300 name: pectoral appendage blood vessel +def: "A blood vessel that is part of a pectoral appendage." [OBOL:automatic] +xref: TAO:0005301 +xref: ZFA:0005301 is_a: UBERON:0007301 ! appendage blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage @@ -40947,6 +62539,9 @@ relationship: BFO:0000050 UBERON:0004710 ! part of pectoral appendage [Term] id: UBERON:0007301 name: appendage blood vessel +def: "A blood vessel that is part of a limb/fin." [OBOL:automatic] +xref: TAO:0005299 +xref: ZFA:0005299 is_a: UBERON:0001981 ! blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0000026 ! part of appendage @@ -40955,6 +62550,9 @@ relationship: BFO:0000050 UBERON:0007304 ! part of appendage vasculature [Term] id: UBERON:0007302 name: pectoral appendage vasculature +def: "A vasculature that is part of a pectoral appendage." [OBOL:automatic] +xref: TAO:0005096 +xref: ZFA:0005096 is_a: UBERON:0007304 ! appendage vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage @@ -40963,6 +62561,9 @@ relationship: BFO:0000050 UBERON:0004710 ! part of pectoral appendage [Term] id: UBERON:0007303 name: pharyngeal vasculature +def: "A vasculature that is part of a chordate pharynx." [OBOL:automatic] +xref: TAO:0005003 +xref: ZFA:0005003 is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001042 ! part of chordate pharynx @@ -40971,14 +62572,68 @@ relationship: BFO:0000050 UBERON:0001042 ! part of chordate pharynx [Term] id: UBERON:0007304 name: appendage vasculature +def: "A vasculature that is part of a limb/fin." [OBOL:automatic] +xref: TAO:0005095 +xref: ZFA:0005095 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000026 ! part of appendage relationship: BFO:0000050 UBERON:0000026 ! part of appendage +[Term] +id: UBERON:0007324 +name: pancreatic lobule +def: "A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans." [ISBN:0123813611] +xref: FMA:16012 +xref: MA:0000721 +is_a: UBERON:0000064 ! organ part +is_a: UBERON:0004119 ! endoderm-derived structure +relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000051 UBERON:0001263 ! has part pancreatic acinus +relationship: BFO:0000051 UBERON:0014719 ! has part intralobular duct + +[Term] +id: UBERON:0007329 +name: pancreatic duct +def: "A duct that collects and carries secretions of the exocrine pancreas to the intestine." [GOC:cvs, GOC:ymb, https://github.com/obophenotype/uberon/issues/1250, https://orcid.org/0000-0002-2244-7917, https://orcid.org/0000-0002-6601-2165, https://orcid.org/0000-0002-9900-7880, Wikipedia:Pancreatic_duct] +xref: EHDAA:9194 +xref: EMAPA:32952 +xref: FMA:10419 +xref: MA:0000124 +xref: SCTID:181278006 +xref: TAO:0001372 +xref: VHOG:0000254 +xref: Wikipedia:Pancreatic_duct +xref: ZFA:0001372 +is_a: UBERON:0003928 ! digestive system duct +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000058 ! duct +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +intersection_of: RO:0002170 UBERON:0000160 ! intestine +relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: RO:0002170 UBERON:0000160 ! intestine +relationship: RO:0002202 UBERON:0003922 ! pancreatic epithelial bud +relationship: RO:0002433 UBERON:0000017 ! exocrine pancreas + +[Term] +id: UBERON:0007375 +name: roof of mouth +def: "A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones." [https://orcid.org/0000-0002-6601-2165] +xref: CALOHA:TS-2212 +xref: Wikipedia:Palate +is_a: UBERON:0000481 ! multi-tissue structure +relationship: BFO:0000050 UBERON:0000033 ! part of head + [Term] id: UBERON:0007376 name: outer epithelium +def: "The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]." [GO:0008544] +xref: BSA:0000073 +xref: BTO:0000313 +xref: HAO:0000298 +xref: TADS:0000109 +xref: WBbt:0005733 +xref: Wikipedia:Epidermis_(zoology) is_a: UBERON:0003102 ! surface structure is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium @@ -40991,6 +62646,10 @@ relationship: RO:0002202 UBERON:0007383 ! enveloping layer of ectoderm [Term] id: UBERON:0007383 name: enveloping layer of ectoderm +def: "Outermost layer of cells surrounding the embryo." [http://orcid.org/0000-0002-6601-2165] +xref: EFO:0003425 +xref: TAO:0000086 +xref: ZFA:0000086 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0010371 ! ecto-epithelium @@ -41000,6 +62659,9 @@ relationship: RO:0002202 UBERON:0000076 ! external ectoderm [Term] id: UBERON:0007389 name: paired limb/fin cartilage +def: "A cartilage tissue that is part of a paired limb or fin." [http://orcid.org/0000-0002-6601-2165] +xref: TAO:0001543 +xref: ZFA:0001543 is_a: UBERON:0002418 ! cartilage tissue intersection_of: UBERON:0002418 ! cartilage tissue intersection_of: BFO:0000050 UBERON:0004708 ! part of paired limb/fin @@ -41009,6 +62671,9 @@ relationship: BFO:0000050 UBERON:0004708 ! part of paired limb/fin [Term] id: UBERON:0007390 name: pectoral appendage cartilage tissue +def: "A cartilage tissue that is part of a pectoral appendage." [OBOL:automatic] +xref: TAO:0000257 +xref: ZFA:0000257 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007389 ! paired limb/fin cartilage intersection_of: UBERON:0002418 ! cartilage tissue @@ -41019,6 +62684,9 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0007414 name: nucleus of midbrain tegmentum +def: "A nucleus of brain that spans a midbrain tegmentum." [OBOL:automatic] +xref: FMA:258768 +xref: ZFA:0005577 is_a: UBERON:0000125 ! neural nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: RO:0002131 UBERON:0001943 ! overlaps midbrain tegmentum @@ -41027,6 +62695,8 @@ relationship: RO:0002131 UBERON:0001943 ! overlaps midbrain tegmentum [Term] id: UBERON:0007473 name: lumen of epithelial sac +def: "The space within an epithelial sphere." [AEO:JB] +xref: AEO:0000079 is_a: UBERON:0012467 ! enclosed anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0007499 ! epithelial sac @@ -41035,6 +62705,9 @@ relationship: RO:0002572 UBERON:0007499 ! epithelial sac [Term] id: UBERON:0007475 name: matrix-based tissue +def: "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified." [AEO:JB] +xref: AEO:0000081 +xref: EHDAA2:0003081 is_a: UBERON:0000479 ! tissue intersection_of: UBERON:0000479 ! tissue intersection_of: RO:0002473 GO:0031012 ! extracellular matrix @@ -41043,6 +62716,9 @@ relationship: RO:0002473 GO:0031012 ! extracellular matrix [Term] id: UBERON:0007499 name: epithelial sac +def: "An epithelial tube that is open at one end only." [AEO:JB, UBERONREF:0000001] +xref: AEO:0000115 +xref: EHDAA2:0003115 is_a: UBERON:0003914 ! epithelial tube is_a: UBERON:0009856 ! sac intersection_of: UBERON:0000483 ! epithelium @@ -41051,22 +62727,59 @@ intersection_of: RO:0000086 PATO:0001987 [Term] id: UBERON:0007500 name: epithelial tube open at both ends +def: "An epithelial tube open at both ends that allows fluid flow." [AEO:JB, UBERONREF:0000001] +xref: AEO_RETIRED:0000116 +xref: RETIRED_EHDAA2:0003116 is_a: UBERON:0003914 ! epithelial tube [Term] id: UBERON:0007503 name: epithelial vesicle +def: "A closed epithelium with a lumen." [AEO:JB] +xref: AEO:0000119 +xref: EHDAA2:0003119 is_a: UBERON:0000483 ! epithelium +[Term] +id: UBERON:0007521 +name: smooth muscle sphincter +def: "A ring of smooth muscle cells whose contraction closes the opening of the ring." [AEO:JB] +xref: AEO:0000143 +xref: EHDAA2:0003143 +xref: SCTID:362915001 +is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000051 CL:0000192 ! has part smooth muscle cell +relationship: BFO:0000051 CL:0000192 ! has part smooth muscle cell +relationship: RO:0002473 UBERON:0001135 ! smooth muscle tissue + +[Term] +id: UBERON:0007522 +name: striated muscle sphincter +def: "A ring of striated muscle cells whose contraction closes the opening of the ring." [AEO:JB] +xref: AEO:0000144 +xref: EHDAA2:0003144 +is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000051 CL:0000737 ! has part striated muscle cell +relationship: BFO:0000051 CL:0000737 ! has part striated muscle cell +relationship: RO:0002473 UBERON:0002036 ! striated muscle tissue + [Term] id: UBERON:0007524 name: dense mesenchyme tissue +def: "Mesenchyme with little extracellular matrix." [AEO:JB] +xref: AEO:0000146 +xref: EHDAA2:0003146 is_a: UBERON:0003104 ! mesenchyme relationship: BFO:0000051 CL:0000057 ! has part fibroblast [Term] id: UBERON:0007530 name: migrating mesenchyme population +def: "Mesenchymal cells that are migrating." [AEO:JB] +xref: AEO:0000152 +xref: EHDAA2:0003152 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0000056 GO:0016477 ! participates in cell migration @@ -41075,6 +62788,8 @@ relationship: RO:0000056 GO:0016477 ! participates in cell migration [Term] id: UBERON:0007592 name: ciliated columnar epithelium +def: "Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]." [FMA:64798] +xref: FMA:64798 is_a: UBERON:0000485 ! simple columnar epithelium is_a: UBERON:0007601 ! ciliated epithelium intersection_of: UBERON:0000485 ! simple columnar epithelium @@ -41083,6 +62798,7 @@ intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell [Term] id: UBERON:0007601 name: ciliated epithelium +def: "Epithelium bearing vibratile cilia on the free surface." [http://medical-dictionary.thefreedictionary.com/ciliated+epithelium] is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell @@ -41091,6 +62807,10 @@ relationship: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell [Term] id: UBERON:0007616 name: layer of synovial tissue +def: "A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]." [BTO:0001338, http://www.britannica.com/EBchecked/topic/578563/synovial-tissue] +xref: BTO:0001338 +xref: CALOHA:TS-0998 +xref: FMA:66762 is_a: UBERON:0000042 ! serous membrane intersection_of: UBERON:0000042 ! serous membrane intersection_of: RO:0003000 UBERON:0001090 ! produces synovial fluid @@ -41100,6 +62820,8 @@ relationship: RO:0003000 UBERON:0001090 ! produces synovial fluid [Term] id: UBERON:0007617 name: synovial cavity of joint +def: "An anatomical cavity that surrounded_by a synovial joint." [OBOL:automatic] +xref: FMA:11356 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002217 ! synovial joint @@ -41108,6 +62830,9 @@ relationship: RO:0002572 UBERON:0002217 ! synovial joint [Term] id: UBERON:0007625 name: pigment epithelium of eye +def: "Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules." [MP:0005200] +xref: GAID:907 +xref: MESH:D010857 is_a: UBERON:0019304 ! sensory organ epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000970 ! part of eye @@ -41116,6 +62841,9 @@ relationship: BFO:0000050 UBERON:0000970 ! part of eye [Term] id: UBERON:0007635 name: nucleus of medulla oblongata +def: "A neural nucleus that is part of a medulla oblongata." [OBOL:automatic] +xref: FMA:258772 +xref: SCTID:304943004 is_a: UBERON:0006331 ! brainstem nucleus is_a: UBERON:0009662 ! hindbrain nucleus intersection_of: UBERON:0000125 ! neural nucleus @@ -41125,6 +62853,15 @@ relationship: BFO:0000050 UBERON:0001896 ! part of medulla oblongata [Term] id: UBERON:0007641 name: trigeminal nuclear complex +def: "The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]." [Wikipedia:Trigeminal_nerve_nuclei] +xref: BIRNLEX:4096 +xref: BM:V +xref: CALOHA:TS-2077 +xref: DHBA:266441713 +xref: FMA:71248 +xref: HBA:9203 +xref: neuronames:2021 +xref: Wikipedia:Trigeminal_nerve_nuclei is_a: UBERON:0007245 ! nuclear complex of neuraxis relationship: extends_fibers_into UBERON:0001645 ! trigeminal nerve relationship: RO:0002131 UBERON:0003023 ! overlaps pontine tegmentum @@ -41132,21 +62869,42 @@ relationship: RO:0002131 UBERON:0003023 ! overlaps pontine tegmentum [Term] id: UBERON:0007651 name: anatomical junction +def: "An anatomical structure that connects two structures." [http://code.google.com/p/caro2/issues/detail?id=15] +xref: FMA:5898 +xref: SCTID:91833003 is_a: UBERON:0000061 ! anatomical structure relationship: RO:0002176 UBERON:0000061 {minCardinality="2"} ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 + +[Term] +id: UBERON:0007652 +name: esophageal sphincter +def: "A sphincter that is part of an esophagus." [http://orcid.org/0000-0002-6601-2165] +xref: SCTID:277765007 +is_a: UBERON:0003832 ! esophagus muscle +is_a: UBERON:0004590 ! sphincter muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus [Term] id: UBERON:0007688 name: anlage +def: "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue." [FBbt:00005426, http://flybase.org/reports/FBrf0178740.html] +xref: AEO:0000170 +xref: EFO:0001649 +xref: EHDAA2:0003170 +xref: Wikipedia:Anlage_(biology) is_a: UBERON:0000479 ! tissue is_a: UBERON:0005423 ! developing anatomical structure [Term] id: UBERON:0007690 name: early pharyngeal endoderm +comment: relation conflict: ZFA vs EHDAA2. Note EHDAA2 term renamed to 'early PA endoderm' +xref: EFO:0003626 +xref: EHDAA2:0001457 +xref: EHDAA:962 +xref: TAO:0001104 +xref: ZFA:0001104 is_a: UBERON:0003258 ! endoderm of foregut is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0009722 ! part of entire pharyngeal arch endoderm @@ -41154,6 +62912,7 @@ relationship: BFO:0000050 UBERON:0009722 ! part of entire pharyngeal arch endode [Term] id: UBERON:0007719 name: bone of reproductive organ +def: "A bone that is part of a reproductive organ." [https://github.com/obophenotype/uberon/issues/1158, OBOL:automatic] is_a: UBERON:0001474 ! bone element is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0001474 ! bone element @@ -41163,6 +62922,8 @@ relationship: BFO:0000050 UBERON:0003133 ! part of reproductive organ [Term] id: UBERON:0007771 name: epidermis gland +def: "A gland that is part of a epidermis." [OBOL:automatic] +xref: FMA:59153 is_a: UBERON:0002419 ! skin gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001003 ! part of skin epidermis @@ -41171,6 +62932,11 @@ relationship: BFO:0000050 UBERON:0001003 ! part of skin epidermis [Term] id: UBERON:0007779 name: transudate +def: "Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces." [http://medical-dictionary.thefreedictionary.com/transudate] +xref: FMA:12276 +xref: GAID:1195 +xref: MESH:D005122 +xref: ncithesaurus:Transudate is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0000463 ! organism substance intersection_of: filtered_through UBERON:0001982 ! capillary @@ -41183,6 +62949,8 @@ relationship: RO:0002494 UBERON:0001969 ! blood plasma [Term] id: UBERON:0007794 name: secretion of serous gland +def: "Any fluid produced by a serous gland." [UBERON:cjm] +xref: Wikipedia:Serous_fluid is_a: UBERON:0000456 ! secretion of exocrine gland is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid @@ -41192,13 +62960,22 @@ relationship: RO:0003001 UBERON:0000409 ! produced by serous gland [Term] id: UBERON:0007798 name: vascular system +def: "Anatomical system that consists of all blood and lymph vessels." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0001085 +xref: CALOHA:TS-2053 +xref: EHDAA2:0004520 +xref: EMAPA:35905 +xref: MA:0002718 +xref: NCIT:C33854 is_a: UBERON:0000467 ! anatomical system relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007808 name: adipose tissue of abdominal region +def: "Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots." [CALOHA:paula, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/259, MGI:csmith] +xref: CALOHA:TS-0002 +xref: EFO:0003771 is_a: UBERON:0001013 ! adipose tissue is_a: UBERON:0003567 ! abdomen connective tissue intersection_of: UBERON:0001013 ! adipose tissue @@ -41207,6 +62984,15 @@ intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0007811 name: craniocervical region +def: "The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae." [https://orcid.org/0000-0002-6601-2165] +xref: CALOHA:TS-2356 +xref: EV:0100009 +xref: FMA:280881 +xref: galen:HeadAndNeck +xref: MA:0000006 +xref: NCIT:C12418 +xref: SCTID:361355005 +xref: WikipediaCategory:Head_and_neck is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0000153 ! part of anterior region of body relationship: BFO:0000050 UBERON:0013702 ! part of body proper @@ -41214,9 +63000,30 @@ relationship: BFO:0000051 UBERON:0000033 ! has part head relationship: BFO:0000051 UBERON:0000974 {gci_filler="NCBITaxon:32523", gci_relation="BFO:0000050"} ! has part neck relationship: BFO:0000051 UBERON:0006562 ! has part pharynx +[Term] +id: UBERON:0007812 +name: post-anal tail +def: "A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0010338 +xref: MA:0000008 +xref: NCIT:C77663 +xref: TAO:0001117 +xref: XAO:0003026 +xref: ZFA:0001117 +is_a: UBERON:0002415 ! tail +intersection_of: UBERON:0002415 ! tail +intersection_of: BFO:0000050 UBERON:0006071 ! part of caudal region +relationship: BFO:0000050 UBERON:0006071 ! part of caudal region +relationship: RO:0002160 NCBITaxon:7711 ! Chordata +relationship: RO:0002216 GO:0007626 ! capable of part of locomotory behavior +relationship: RO:0002494 UBERON:0007144 ! embryonic post-anal tail + [Term] id: UBERON:0007823 name: appendage girdle region +def: "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: FMA:24874 +xref: VSAO:0000303 is_a: UBERON:0000475 ! organism subdivision intersection_of: UBERON:0000475 ! organism subdivision intersection_of: RO:0002551 UBERON:0010719 ! girdle skeleton @@ -41224,9 +63031,26 @@ relationship: BFO:0000050 UBERON:0010707 ! part of appendage girdle complex relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002551 UBERON:0010719 ! girdle skeleton +[Term] +id: UBERON:0007826 +name: peritoneal mesentery +def: "Mesentery that is located in the peritoneum." [UBERON:cjm] +xref: FMA:20570 +xref: TAO:0005129 +xref: XAO:0000138 +xref: ZFA:0005129 +is_a: UBERON:0002095 ! mesentery +is_a: UBERON:0002358 ! peritoneum +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0002358 ! part of peritoneum +relationship: BFO:0000050 UBERON:0001178 ! part of visceral peritoneum + [Term] id: UBERON:0007828 name: girdle bone/zone +def: "A bone that is part of a appendage girdle region." [OBOL:automatic] +xref: EMAPA:35379 +xref: MA:0000291 is_a: UBERON:0010740 ! bone of appendage girdle complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0007823 ! part of appendage girdle region @@ -41235,16 +63059,33 @@ relationship: BFO:0000050 UBERON:0010719 ! part of girdle skeleton [Term] id: UBERON:0007829 name: pectoral girdle bone +def: "A bone that is part of a pectoral girdle region." [OBOL:automatic] +xref: EMAPA:35669 +xref: MA:0000292 is_a: UBERON:0007828 ! girdle bone/zone is_a: UBERON:0010741 ! bone of pectoral complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region relationship: BFO:0000050 UBERON:0007831 ! part of pectoral girdle skeleton -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0007831 name: pectoral girdle skeleton +def: "A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons." [Wikipedia:Pectoral_girdle] +xref: AAO:0000422 +xref: AAO:0000754 +xref: EFO:0000946 +xref: EHDAA2:0001420 +xref: FMA:24141 +xref: MAT:0000181 +xref: MIAA:0000181 +xref: NCIT:C33547 +xref: TAO:0000407 +xref: VHOG:0001156 +xref: VSAO:0000156 +xref: Wikipedia:Pectoral_girdle +xref: XAO:0003063 +xref: ZFA:0000407 is_a: UBERON:0010719 ! girdle skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region @@ -41256,12 +63097,26 @@ relationship: RO:0002576 UBERON:0001421 ! pectoral girdle region [Term] id: UBERON:0007842 name: membrane bone +def: "Bone element that arises as a result of intramembranous ossification." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/267, VSAO:0000023] +xref: AEO:0000085 +xref: EHDAA2:0003085 +xref: TAO:0001645 +xref: VSAO:0000023 +xref: XAO:0004014 +xref: ZFA:0001636 is_a: UBERON:0001474 ! bone element relationship: RO:0002353 GO:0001957 ! output of intramembranous ossification [Term] id: UBERON:0007844 name: cartilage element +def: "Skeletal element that is composed of cartilage tissue and may be permanent or transient." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000000] +xref: AAO:0011130 +xref: CALOHA:TS-0118 +xref: FMA:55107 +xref: VSAO:0000000 +xref: XAO:0004013 +xref: ZFA:0001501 is_a: UBERON:0004765 ! skeletal element intersection_of: UBERON:0004765 ! skeletal element intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue @@ -41272,6 +63127,8 @@ relationship: RO:0002473 UBERON:0002418 ! cartilage tissue [Term] id: UBERON:0007845 name: regular connective tissue +def: "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue." [FMA:20103] +xref: FMA:20103 is_a: UBERON:0002384 ! connective tissue disjoint_from: UBERON:0011821 ! irregular connective tissue relationship: BFO:0000051 CL:0000057 ! has part fibroblast @@ -41281,6 +63138,13 @@ relationship: BFO:0000051 UBERON:0011860 ! has part collection of collagen fibri [Term] id: UBERON:0007846 name: dense regular connective tissue +def: "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts)." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000050] +xref: FMA:64781 +xref: NCIT:C33453 +xref: SCTID:22560007 +xref: VSAO:0000050 +xref: Wikipedia:Dense_regular_connective_tissue +xref: XAO:0004030 is_a: UBERON:0007845 ! regular connective tissue is_a: UBERON:0011823 ! dense connective tissue intersection_of: UBERON:0007845 ! regular connective tissue @@ -41290,14 +63154,28 @@ intersection_of: RO:0002473 UBERON:0011860 ! collection of collagen fibrils [Term] id: UBERON:0007914 name: bone of craniocervical region +def: "A bone that is part of a craniocervical region." [OBOL:automatic] +xref: MA:0000569 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region +[Term] +id: UBERON:0008001 +name: irregular bone +def: "The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid." [Wikipedia:Irregular_bone] +xref: FMA:7477 +xref: NCIT:C32881 +xref: SCTID:421560006 +xref: Wikipedia:Irregular_bone +is_a: UBERON:0001474 ! bone element + [Term] id: UBERON:0008114 name: joint of girdle +def: "A skeletal joint that is part of a appendage girdle region." [OBOL:automatic] +xref: MA:0001505 is_a: UBERON:0000982 ! skeletal joint intersection_of: UBERON:0000982 ! skeletal joint intersection_of: BFO:0000050 UBERON:0007823 ! part of appendage girdle region @@ -41308,14 +63186,31 @@ relationship: RO:0002176 UBERON:0007828 ! girdle bone/zone [Term] id: UBERON:0008115 name: surface of cartilage +def: "An anatomical surface that is part of a cartilage element." [OBOL:automatic] +xref: FMA:76668 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: RO:0002007 UBERON:0007844 ! bounding layer of cartilage element relationship: RO:0002007 UBERON:0007844 ! bounding layer of cartilage element +[Term] +id: UBERON:0008193 +name: pneumatized bone +def: "A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]." [http://www.medilexicon.com/medicaldictionary.php?t=11303] +xref: FMA:7478 +xref: galen:PneumaticBone +xref: SCTID:333008005 +xref: Wikipedia:Skeletal_pneumaticity +is_a: UBERON:0001474 ! bone element +intersection_of: UBERON:0001474 ! bone element +intersection_of: BFO:0000051 UBERON:0010528 ! has part pneumatic cavity of bone +relationship: BFO:0000051 UBERON:0010528 ! has part pneumatic cavity of bone + [Term] id: UBERON:0008196 name: muscle of pectoral girdle +def: "Any muscle organ that is part of a pectoral girdle region." [OBOL:automatic] +xref: FMA:37347 is_a: UBERON:0010891 ! pectoral complex muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region @@ -41324,6 +63219,10 @@ relationship: BFO:0000050 UBERON:0004471 ! part of musculature of pectoral girdl [Term] id: UBERON:0008229 name: craniocervical region musculature +def: "Musculature system of the pharyngeal and head regions." [ZFA:0000328, ZFA:curator] +xref: MA:0000571 +xref: TAO:0000328 +xref: ZFA:0000328 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region @@ -41332,6 +63231,10 @@ relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region [Term] id: UBERON:0008231 name: dorsal thoracic segment of trunk +def: "Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax." [FMA:24217] +xref: FMA:24217 +xref: MA:0000028 +xref: SCTID:362666008 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0011270 ! part of dorsal trunk @@ -41339,6 +63242,9 @@ relationship: BFO:0000050 UBERON:0011270 ! part of dorsal trunk [Term] id: UBERON:0008243 name: upper back muscle +def: "A muscle of back that is part of a dorsal thoracic segment of trunk." [OBOL:automatic] +xref: MA:0000508 +xref: SCTID:305071003 is_a: UBERON:0002324 ! muscle of back is_a: UBERON:0003830 ! thoracic segment muscle intersection_of: UBERON:0002324 ! muscle of back @@ -41348,6 +63254,8 @@ relationship: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of tr [Term] id: UBERON:0008307 name: heart endothelium +def: "An endothelium that is part of a heart [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004293 is_a: UBERON:0004852 ! cardiovascular system endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0000948 ! part of heart @@ -41356,14 +63264,42 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart [Term] id: UBERON:0008339 name: microvascular endothelium +xref: BTO:0003122 is_a: UBERON:0004638 ! blood vessel endothelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:8410081 ! part of blood microvessel relationship: BFO:0000050 UBERON:8410081 ! part of blood microvessel +[Term] +id: UBERON:0008342 +name: intestinal villus of duodenum +def: "An intestinal villus in the duodenum." [OBOL:automatic] +xref: FMA:63300 +is_a: UBERON:0001213 ! intestinal villus +intersection_of: UBERON:0001213 ! intestinal villus +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0000320 ! part of duodenal mucosa + +[Term] +id: UBERON:0008346 +name: duodenal epithelium +def: "An epithelium that is part of a duodenum." [OBOL:automatic] +xref: CALOHA:TS-2087 +xref: EMAPA:19078 +xref: FMA:17231 +xref: MA:0003208 +xref: SCTID:66036002 +is_a: UBERON:0013636 ! epithelium of intestinal villus +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0008342 ! part of intestinal villus of duodenum + [Term] id: UBERON:0008397 name: tracheobronchial epithelium +def: "Epithelium pertaining to the trachea and bronchi." [Dorlands_Medical_Dictionary:MerckMedicus] +xref: BTO:0002925 +xref: CALOHA:TS-1063 is_a: UBERON:0004815 ! lower respiratory tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree @@ -41372,6 +63308,13 @@ relationship: BFO:0000050 UBERON:0007196 ! part of tracheobronchial tree [Term] id: UBERON:0008780 name: inner cell mass derived epiblast +def: "An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers." [MP:0003886] +comment: The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5. +xref: EHDAA2:0000444 +xref: EHDAA:42 +xref: EHDAA:75 +xref: EMAPA:16050 +xref: NCIT:C34164 is_a: UBERON:0002532 ! epiblast (generic) intersection_of: UBERON:0002532 ! epiblast (generic) intersection_of: RO:0002202 UBERON:0000087 ! inner cell mass @@ -41381,6 +63324,10 @@ relationship: RO:0002202 UBERON:0000087 ! inner cell mass [Term] id: UBERON:0008814 name: pharyngeal arch system +def: "A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]." [GO:0060037, GOC:dph] +xref: EHDAA2:0000187 +xref: FMA:293041 +xref: NCIT:C34248 is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: BFO:0000050 UBERON:0009145 ! part of pharyngeal region of foregut @@ -41389,6 +63336,9 @@ relationship: RO:0002160 NCBITaxon:7711 ! Chordata [Term] id: UBERON:0008816 name: embryonic head +def: "A head that is part of a embryo." [OBOL:automatic] +xref: CALOHA:TS-0246 +xref: FMA:293011 is_a: UBERON:0000033 ! head intersection_of: UBERON:0000033 ! head intersection_of: BFO:0000050 UBERON:0000922 ! part of embryo @@ -41397,6 +63347,7 @@ relationship: BFO:0000050 UBERON:0000922 ! part of embryo [Term] id: UBERON:0008823 name: neural tube derived brain +def: "A brain that develops_from a neural tube." [https://github.com/obophenotype/uberon/issues/338, OBOL:automatic] is_a: UBERON:0000489 ! cavitated compound organ is_a: UBERON:0000955 ! brain intersection_of: UBERON:0000955 ! brain @@ -41407,24 +63358,106 @@ relationship: RO:0002202 UBERON:0001049 ! neural tube [Term] id: UBERON:0008826 name: pulmonary surfactant +def: "A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein)." [Wikipedia:Pulmonary_surfactant] +xref: EMAPA:36551 +xref: FMA:62780 +xref: MA:0002534 +xref: NCIT:C13273 +xref: Wikipedia:Pulmonary_surfactant is_a: UBERON:0006538 ! respiratory system fluid/secretion intersection_of: UBERON:0006538 ! respiratory system fluid/secretion intersection_of: RO:0003001 CL:0002063 ! produced by pulmonary alveolar type 2 cell relationship: BFO:0000051 CHEBI:6495 ! has part relationship: RO:0003001 CL:0002063 ! produced by pulmonary alveolar type 2 cell +[Term] +id: UBERON:0008835 +name: hepatic diverticulum +def: "An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts." [http://www.stembook.org/node/512, MP:MP] +xref: AAO:0011057 +xref: EHDAA2:0000740 +xref: EHDAA:1530 +xref: NCIT:C34187 +xref: Wikipedia:Hepatic_diverticulum +xref: XAO:0000101 +is_a: UBERON:0004185 ! endodermal part of digestive tract +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0007499 ! epithelial sac +is_a: UBERON:0009497 ! epithelium of foregut-midgut junction +is_a: UBERON:0009854 ! digestive tract diverticulum +relationship: BFO:0000050 UBERON:0004161 ! part of septum transversum +relationship: RO:0002202 UBERON:0003894 ! liver primordium + +[Term] +id: UBERON:0008836 +name: liver bud +xref: BTO:0001642 +is_a: UBERON:0004185 ! endodermal part of digestive tract +is_a: UBERON:0007499 ! epithelial sac +is_a: UBERON:0009497 ! epithelium of foregut-midgut junction +is_a: UBERON:0009854 ! digestive tract diverticulum +relationship: RO:0002202 UBERON:0008835 ! hepatic diverticulum + [Term] id: UBERON:0008851 name: ectoplacental cavity +def: "Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals." [http://www.medilexicon.com/medicaldictionary.php?s=epamniotic+cavity, MP:0011207] +xref: EMAPA:16080 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0004364 ! ectoplacental cone relationship: BFO:0000050 UBERON:0004364 ! part of ectoplacental cone relationship: RO:0002572 UBERON:0004364 ! ectoplacental cone +[Term] +id: UBERON:0008856 +name: stomach muscularis externa +def: "The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines." [MP:0010779] +xref: FMA:14909 +xref: SCTID:362132003 +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0018261 ! muscular coat of digestive tract +is_a: UBERON:0034933 ! layer of smooth muscle tissue +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001167 ! part of wall of stomach +relationship: BFO:0000050 UBERON:0004222 ! part of stomach smooth muscle +relationship: RO:0002433 UBERON:0001135 ! smooth muscle tissue +relationship: RO:0002433 UBERON:0001167 ! wall of stomach + +[Term] +id: UBERON:0008858 +name: pyloric canal +def: "The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter." [MP:0010791, Wikipedia:Pyloric_canal] +xref: FMA:14580 +xref: SCTID:245417002 +xref: Wikipedia:Pyloric_canal +is_a: UBERON:0009870 ! zone of stomach +relationship: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: RO:0002150 UBERON:0001165 ! pyloric antrum +relationship: RO:0002150 UBERON:0001202 ! pyloric sphincter +relationship: RO:0002433 UBERON:0001166 ! pylorus + +[Term] +id: UBERON:0008861 +name: pyloric gastric gland +def: "The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]." [MP:0010797, Wikipedia:Pyloric_gland] +xref: EMAPA:27211 +xref: FMA:14922 +xref: NCIT:C33431 +xref: SCTID:70710007 +xref: Wikipedia:Pyloric_gland +is_a: UBERON:0000325 ! gastric gland +is_a: UBERON:0000414 ! mucous gland +intersection_of: UBERON:0000325 ! gastric gland +intersection_of: BFO:0000050 UBERON:0001166 ! part of pylorus +relationship: BFO:0000050 UBERON:0004998 ! part of mucosa of pylorus +relationship: RO:0000086 PATO:0002299 +relationship: RO:0002433 UBERON:0001166 ! pylorus + [Term] id: UBERON:0008870 name: pulmonary alveolar parenchyma +def: "The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages." [MP:0010901] is_a: UBERON:0008946 ! lung parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: BFO:0000050 UBERON:0002299 ! part of alveolus of lung @@ -41433,20 +63466,26 @@ relationship: BFO:0000051 CL:0002062 ! has part pulmonary alveolar type 1 cell relationship: BFO:0000051 CL:0002063 ! has part pulmonary alveolar type 2 cell relationship: BFO:0000051 CL:0009089 ! has part lung pericyte relationship: RO:0002433 UBERON:0006524 ! alveolar system -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008874 name: pulmonary acinus +def: "The largest lung subunit in which all airways participate in gas exchange, and it is composed of the parenchyma of the respiratory bronchioles, alveolar ducts, and alveoli." [MP:0010911, PMID:2014492, PMID:3382030, Wikipedia:Acinus#The_Lungs] +xref: FMA:7313 +xref: NCIT:C33426 +xref: SCTID:361365004 +xref: Wikipedia:Acinus#The_Lungs is_a: BFO:0000004 is_a: UBERON:0001062 ! anatomical entity relationship: BFO:0000050 UBERON:0010369 ! part of secondary pulmonary lobule relationship: RO:0002170 UBERON:0002187 ! terminal bronchiole -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008876 name: hypodermis skeletal muscle layer +def: "Any skeletal muscle organ in the hypodermis / superficial fascia." [ISBN:0123813611, MP:0011157] +xref: EMAPA:18188 +xref: MA:0003140 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004253 ! skin muscle is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate @@ -41461,24 +63500,40 @@ relationship: RO:0002433 UBERON:0002072 ! hypodermis [Term] id: UBERON:0008886 name: pulmonary vascular system +def: "The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins." [ISBN:0073040584, Wikipedia:Pulmonary_circulation] +xref: FMA:45621 +xref: Wikipedia:Pulmonary_circulation is_a: UBERON:0007798 ! vascular system relationship: BFO:0000051 UBERON:0002012 ! has part pulmonary artery relationship: BFO:0000051 UBERON:0002016 ! has part pulmonary vein -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008895 name: splanchnocranium +def: "Subdivision of endoskeleton derived from pharyngeal arches." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584, Wikipedia:Facial_skeleton] +xref: AAO:0010157 +xref: TAO:0001216 +xref: VHOG:0000315 +xref: VSAO:0000149 +xref: Wikipedia:Facial_skeleton +xref: XAO:0003176 +xref: ZFA:0001216 is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system disjoint_from: UBERON:0011156 ! facial skeleton relationship: RO:0002131 UBERON:0011156 {gci_filler="NCBITaxon:89593", gci_relation="BFO:0000050"} ! overlaps facial skeleton relationship: RO:0002202 UBERON:0002539 ! pharyngeal arch relationship: RO:0002254 UBERON:0003099 ! cranial neural crest -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0008907 name: dermal bone +def: "Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/267, VSAO:0000130] +xref: AAO:0010769 +xref: TAO:0001590 +xref: VSAO:0000130 +xref: Wikipedia:Dermal_bone +xref: XAO:0004015 +xref: ZFA:0001590 is_a: UBERON:0004756 ! dermal skeletal element is_a: UBERON:0007842 ! membrane bone intersection_of: UBERON:0001474 ! bone element @@ -41488,6 +63543,11 @@ relationship: BFO:0000050 UBERON:0010364 ! part of dermal skeleton [Term] id: UBERON:0008909 name: perichordal bone +def: "Bone element that is adjacent to the notochord." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000307] +xref: AAO:0010777 +xref: TAO:0001639 +xref: VSAO:0000307 +xref: ZFA:0001629 is_a: UBERON:0012075 ! replacement bone intersection_of: UBERON:0001474 ! bone element intersection_of: RO:0002220 UBERON:0002328 ! adjacent to notochord @@ -41496,6 +63556,11 @@ relationship: RO:0002220 UBERON:0002328 ! adjacent to notochord [Term] id: UBERON:0008946 name: lung parenchyma +def: "A parenchyma that is part of a lung." [OBOL:automatic] +xref: EMAPA:35522 +xref: FMA:27360 +xref: MA:0003168 +xref: SCTID:201712001 is_a: UBERON:0000353 ! parenchyma is_a: UBERON:0004119 ! endoderm-derived structure intersection_of: UBERON:0000353 ! parenchyma @@ -41505,6 +63570,8 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: UBERON:0008947 name: respiratory primordium +xref: EHDAA2:0004069 +xref: NCIT:C34283 is_a: UBERON:0001048 ! primordium relationship: BFO:0000050 UBERON:0003258 ! part of endoderm of foregut relationship: RO:0002387 UBERON:0001004 ! respiratory system @@ -41512,14 +63579,44 @@ relationship: RO:0002387 UBERON:0001004 ! respiratory system [Term] id: UBERON:0008951 name: left lung lobe +def: "A lobe of lung that is part of a left lung." [OBOL:automatic] +xref: EHDAA:2981 +xref: NCIT:C48945 +xref: SCTID:272655003 is_a: UBERON:0000101 ! lobe of lung intersection_of: UBERON:0000101 ! lobe of lung intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung relationship: BFO:0000050 UBERON:0002168 ! part of left lung +[Term] +id: UBERON:0008989 +name: submucosal esophageal gland +def: "One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed." [BTO:0003634, Wikipedia:Esophageal_glands] +xref: BTO:0003634 +xref: FMA:9404 +xref: NCIT:C32536 +xref: SCTID:322749003 +xref: Wikipedia:Esophageal_glands +is_a: UBERON:0003408 ! gland of digestive tract +is_a: UBERON:0005178 ! thoracic cavity element +is_a: UBERON:0011148 ! submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus +relationship: BFO:0000050 UBERON:0001043 ! part of esophagus +relationship: RO:0001025 UBERON:0001972 ! submucosa of esophagus + [Term] id: UBERON:0008998 name: vasculature of brain +def: "System pertaining to blood vessels in the brain." [BTO:0003840] +xref: BTO:0003840 +xref: EFO:0003491 +xref: EMAPA:35186 +xref: FMA:242007 +xref: FMA:61935 +xref: SCTID:362029003 +xref: TAO:0000099 +xref: ZFA:0000099 is_a: UBERON:0006876 ! vasculature of organ is_a: UBERON:0036303 ! vasculature of central nervous system relationship: BFO:0000050 UBERON:0000955 ! part of brain @@ -41527,6 +63624,9 @@ relationship: BFO:0000050 UBERON:0000955 ! part of brain [Term] id: UBERON:0009015 name: upper back skin +def: "A zone of skin that is part of a dorsal thoracic segment of trunk." [OBOL:automatic] +xref: MA:0000510 +xref: SCTID:304890003 is_a: UBERON:0001068 ! skin of back is_a: UBERON:0001418 ! skin of thorax intersection_of: UBERON:0000014 ! zone of skin @@ -41536,6 +63636,10 @@ relationship: BFO:0000050 UBERON:0008231 ! part of dorsal thoracic segment of tr [Term] id: UBERON:0009030 name: left pulmonary vein +def: "Vein that drains left lung and returns blood to the heart." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0002207 +xref: NCIT:C48946 +xref: SCTID:304057004 is_a: UBERON:0002016 ! pulmonary vein intersection_of: UBERON:0002016 ! pulmonary vein intersection_of: RO:0002179 UBERON:0002168 ! left lung @@ -41544,6 +63648,10 @@ relationship: RO:0002179 UBERON:0002168 ! left lung [Term] id: UBERON:0009032 name: right pulmonary vein +def: "Vein that drains right lung and returns blood to the heart." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0002208 +xref: NCIT:C48947 +xref: SCTID:304056008 is_a: UBERON:0002016 ! pulmonary vein intersection_of: UBERON:0002016 ! pulmonary vein intersection_of: RO:0002179 UBERON:0002167 ! right lung @@ -41552,22 +63660,35 @@ relationship: RO:0002179 UBERON:0002167 ! right lung [Term] id: UBERON:0009117 name: indifferent gonad +def: "A gonad prior to differentiating into a definitive testis or ovary." [http://www.medterms.com/script/main/art.asp?articlekey=8981] +comment: typically part of the embryo - however, in male tammar wallabies the gonads are indifferent at the neonatal stage[8827321] +xref: EHDAA2:0000716 +xref: NCIT:C34192 is_a: UBERON:0000991 ! gonad relationship: BFO:0000050 UBERON:0009196 ! part of indifferent external genitalia [Term] id: UBERON:0009127 name: epibranchial ganglion +def: "Cranial ganglion which develops from an epibranchial placode." [PMID:20133851, ZFIN:curator] +comment: Epibranchial ganglia orchestrate the development of the cranial neurogenic crest +xref: TAO:0001555 +xref: ZFA:0001555 is_a: UBERON:0001714 ! cranial ganglion is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0001714 ! cranial ganglion intersection_of: RO:0002202 UBERON:0003078 ! epibranchial placode relationship: RO:0002202 UBERON:0003078 ! epibranchial placode -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009129 name: right atrium endocardium +def: "Endocardium that is part of the right atrium." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0000274 +xref: FMA:7281 +xref: NCIT:C102339 +xref: SCTID:3194006 +xref: VHOG:0001228 is_a: UBERON:0000487 ! simple squamous epithelium is_a: UBERON:0002166 ! endocardium of atrium is_a: UBERON:0005291 ! embryonic tissue @@ -41581,6 +63702,13 @@ relationship: RO:0002202 UBERON:0005092 ! right horn of sinus venosus [Term] id: UBERON:0009133 name: pleuroperitoneal membrane +def: "A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities." [http://medical-dictionary.thefreedictionary.com/pleuroperitoneal+membrane, Wikipedia:Pleuroperitoneal] +xref: EHDAA2:0001483 +xref: EMAPA:17709 +xref: NCIT:C34256 +xref: SCTID:361429005 +xref: VHOG:0000757 +xref: Wikipedia:Pleuroperitoneal is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0005291 ! embryonic tissue relationship: RO:0002220 UBERON:0001179 ! adjacent to peritoneal cavity @@ -41589,6 +63717,9 @@ relationship: RO:0002220 UBERON:0002402 ! adjacent to pleural cavity [Term] id: UBERON:0009141 name: craniocervical region vein +def: "A vein that is part of a craniocervical region." [OBOL:automatic] +xref: EHDAA2:0004542 +xref: SCTID:32945007 is_a: UBERON:0013140 ! systemic vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region @@ -41597,6 +63728,10 @@ relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region [Term] id: UBERON:0009142 name: entire embryonic mesenchyme +def: "Sum total of mesenchyme in the embryo." [https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/7] +xref: EHDAA2:0001113 +xref: EHDAA:177 +xref: EMAPA:16097 is_a: UBERON:0000477 ! anatomical cluster relationship: BFO:0000050 UBERON:0000922 ! part of embryo relationship: RO:0002254 UBERON:0000926 ! mesoderm @@ -41605,18 +63740,76 @@ relationship: RO:0002473 UBERON:0003104 ! mesenchyme [Term] id: UBERON:0009145 name: pharyngeal region of foregut +xref: EMAPA:16549 +xref: RETIRED_EHDAA2:0001454 is_a: UBERON:0005423 ! developing anatomical structure relationship: BFO:0000050 UBERON:0001041 ! part of foregut +[Term] +id: UBERON:0009191 +name: sphenoid bone pre-cartilage condensation +def: "A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] +xref: EHDAA2:0003446 +xref: EMAPA:18015 +is_a: UBERON:0000481 ! multi-tissue structure +is_a: UBERON:0005866 ! pre-cartilage condensation +is_a: UBERON:0009891 ! facial mesenchyme +is_a: UBERON:0014387 ! mesenchyme derived from neural crest +is_a: UBERON:0015060 ! sphenoid endochondral element +intersection_of: UBERON:0015060 ! sphenoid endochondral element +intersection_of: RO:0002473 UBERON:0005866 ! pre-cartilage condensation +relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium +relationship: BFO:0000050 UBERON:0002241 ! part of chondrocranium +relationship: RO:0002473 UBERON:0005866 ! pre-cartilage condensation + +[Term] +id: UBERON:0009193 +name: sphenoid cartilage element +def: "A sphenoid endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] +xref: EHDAA2:0001888 +is_a: UBERON:0003932 ! cartilage element of chondrocranium +is_a: UBERON:0005863 ! cartilaginous condensation +is_a: UBERON:0009891 ! facial mesenchyme +is_a: UBERON:0014387 ! mesenchyme derived from neural crest +is_a: UBERON:0015060 ! sphenoid endochondral element +intersection_of: UBERON:0015060 ! sphenoid endochondral element +intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue +relationship: RO:0002202 UBERON:0009191 ! sphenoid bone pre-cartilage condensation + [Term] id: UBERON:0009196 name: indifferent external genitalia +xref: EHDAA2:0004021 is_a: UBERON:0004176 ! external genitalia relationship: BFO:0000050 UBERON:0000922 ! part of embryo +[Term] +id: UBERON:0009204 +name: medial nasal process mesenchyme +def: "Mesenchyme that is part of a medial nasal prominence." [OBOL:automatic] +xref: EHDAA2:0001077 +xref: EMAPA:16810 +xref: FMA:312659 +is_a: UBERON:0009501 ! mesenchyme of fronto-nasal process +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0004068 ! part of medial nasal prominence +relationship: BFO:0000050 UBERON:0004068 ! part of medial nasal prominence + +[Term] +id: UBERON:0009292 +name: embryonic nasal process +xref: EHDAA2:0000581 +xref: EHDAA:4776 +xref: EMAPA:16680 +xref: SCTID:308881001 +is_a: UBERON:0012314 ! embryonic facial prominence + [Term] id: UBERON:0009479 name: ectoderm of buccopharyngeal membrane +def: "An ectoderm that is part of a buccopharyngeal membrane." [OBOL:automatic] +xref: EHDAA2:0000190 +xref: EMAPA:16260 is_a: UBERON:0000924 ! ectoderm intersection_of: UBERON:0000924 ! ectoderm intersection_of: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane @@ -41625,14 +63818,43 @@ relationship: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane [Term] id: UBERON:0009480 name: endoderm of buccopharyngeal membrane +def: "An endoderm that is part of a buccopharyngeal membrane." [OBOL:automatic] +xref: EHDAA2:0000191 +xref: EMAPA:16261 is_a: UBERON:0000925 ! endoderm intersection_of: UBERON:0000925 ! endoderm intersection_of: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane relationship: BFO:0000050 UBERON:0006211 ! part of buccopharyngeal membrane +[Term] +id: UBERON:0009482 +name: associated mesenchyme of foregut-midgut junction +def: "Mesenchyme that is part of a foregut-midgut junction." [OBOL:automatic] +xref: EHDAA2:0000570 +xref: EMAPA:16364 +is_a: UBERON:0003104 ! mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction + +[Term] +id: UBERON:0009483 +name: mesentery of foregut-midgut junction +def: "A mesentery that is part of a foregut-midgut junction." [OBOL:automatic] +xref: EHDAA2:0000575 +xref: EMAPA:16365 +xref: VHOG:0000430 +is_a: UBERON:0002095 ! mesentery +intersection_of: UBERON:0002095 ! mesentery +intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction + [Term] id: UBERON:0009494 name: pharyngeal arch mesenchymal region +def: "A portion of mesenchymal tissue associated with an individual pharyngeal arch." [https://orcid.org/0000-0002-6601-2165] +xref: EMAPA:32755 +xref: FMA:295694 is_a: UBERON:0005253 ! head mesenchyme is_a: UBERON:0007524 ! dense mesenchyme tissue intersection_of: UBERON:0003104 ! mesenchyme @@ -41641,9 +63863,51 @@ relationship: BFO:0000050 UBERON:0002539 ! part of pharyngeal arch relationship: BFO:0000050 UBERON:0010046 ! part of entire pharyngeal arch associated mesenchyme relationship: RO:0002254 UBERON:0003099 ! cranial neural crest +[Term] +id: UBERON:0009497 +name: epithelium of foregut-midgut junction +def: "An epithelium that is part of a foregut-midgut junction." [OBOL:automatic] +xref: EHDAA2:0000573 +xref: EMAPA:16564 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0003929 ! digestive tract epithelium +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: BFO:0000050 UBERON:0003929 ! part of digestive tract epithelium +relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: RO:0002202 UBERON:0009550 ! endoderm of foregut-midgut junction + +[Term] +id: UBERON:0009501 +name: mesenchyme of fronto-nasal process +def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head." [MP:0011266] +xref: EHDAA2:0004109 +xref: EMAPA:16683 +xref: FMA:295821 +is_a: UBERON:0007213 ! mesenchyme derived from head neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence +relationship: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence +relationship: RO:0002202 UBERON:0007213 ! mesenchyme derived from head neural crest + +[Term] +id: UBERON:0009503 +name: mesenchyme of hindgut +def: "Mesenchyme that is part of a developing hindgut." [OBOL:automatic] +xref: EHDAA2:0000780 +xref: EMAPA:16716 +is_a: UBERON:0003104 ! mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0001046 ! part of hindgut +relationship: BFO:0000050 UBERON:0001046 ! part of hindgut + [Term] id: UBERON:0009505 name: mesenchyme of trachea +def: "Mesenchyme that is part of a developing trachea." [OBOL:automatic] +xref: EHDAA2:0002067 +xref: EMAPA:16854 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0007524 ! dense mesenchyme tissue intersection_of: UBERON:0003104 ! mesenchyme @@ -41651,15 +63915,108 @@ intersection_of: BFO:0000050 UBERON:0003126 ! part of trachea relationship: BFO:0000050 UBERON:0003126 ! part of trachea relationship: RO:0002202 UBERON:0002539 ! pharyngeal arch +[Term] +id: UBERON:0009521 +name: anal membrane endodermal component +def: "An endoderm that is part of a anal region." [OBOL:automatic] +xref: EHDAA2:0004020 +xref: EMAPA:17177 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000490 ! unilaminar epithelium +intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region +intersection_of: RO:0002202 UBERON:0000925 ! endoderm +relationship: BFO:0000050 UBERON:0001353 ! part of anal region + +[Term] +id: UBERON:0009526 +name: maxillary process mesenchyme +def: "Mesenchyme that is part of a maxillary prominence." [OBOL:automatic] +xref: EHDAA2:0001071 +xref: EMAPA:17361 +xref: FMA:312691 +is_a: UBERON:0003104 ! mesenchyme +is_a: UBERON:0005291 ! embryonic tissue +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0005868 ! part of maxillary prominence +relationship: BFO:0000050 UBERON:0005868 ! part of maxillary prominence + +[Term] +id: UBERON:0009548 +name: hepatic sinusoid of left of lobe of liver +def: "A hepatic sinusoid that is part of a left lobe of liver." [OBOL:automatic] +xref: EHDAA2:0001001 +xref: EMAPA:18309 +xref: VHOG:0000709 +is_a: UBERON:0001281 ! hepatic sinusoid +intersection_of: UBERON:0001281 ! hepatic sinusoid +intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: RO:0002226 UBERON:0001115 ! left lobe of liver + +[Term] +id: UBERON:0009549 +name: hepatic sinusoid of right of lobe of liver +def: "A hepatic sinusoid that is part of a right lobe of liver." [OBOL:automatic] +xref: EHDAA2:0001009 +xref: EMAPA:18316 +xref: VHOG:0000710 +is_a: UBERON:0001281 ! hepatic sinusoid +intersection_of: UBERON:0001281 ! hepatic sinusoid +intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: RO:0002226 UBERON:0001114 ! right lobe of liver + +[Term] +id: UBERON:0009550 +name: endoderm of foregut-midgut junction +def: "An endoderm that is part of a foregut-midgut junction." [OBOL:automatic] +xref: EHDAA2:0000572 +xref: EMAPA:18403 +is_a: UBERON:0000925 ! endoderm +intersection_of: UBERON:0000925 ! endoderm +intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction + +[Term] +id: UBERON:0009566 +name: intestinal submucosa +def: "A submucosa that is part of a intestine." [OBOL:automatic] +xref: FMA:15696 +is_a: UBERON:0018257 ! submucosa of digestive tract +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine + +[Term] +id: UBERON:0009568 +name: trunk region of vertebral column +def: "Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions." [UBERONREF:0000006] +xref: FMA:72066 +xref: NCIT:C92597 +xref: SCTID:281699004 +is_a: UBERON:0006077 ! subdivision of vertebral column +intersection_of: UBERON:0006077 ! subdivision of vertebral column +intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk +intersection_of: subdivision_of UBERON:0002100 ! trunk +relationship: BFO:0000050 UBERON:0002100 ! part of trunk +relationship: subdivision_of UBERON:0002100 ! trunk + [Term] id: UBERON:0009569 name: subdivision of trunk +xref: FMA:25054 +xref: SCTID:22943007 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0002100 ! part of trunk [Term] id: UBERON:0009570 name: spinal cord sulcus limitans +def: "A sulcus limitans of neural tube that is part of a future spinal cord." [OBOL:automatic] +xref: EHDAA2:0001265 +xref: EMAPA:17584 +xref: VHOG:0001548 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord @@ -41668,6 +64025,9 @@ relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord [Term] id: UBERON:0009576 name: medulla oblongata sulcus limitans +def: "A sulcus limitans of neural tube that is part of a future medulla oblongata." [OBOL:automatic] +xref: EHDAA2:0001100 +xref: EMAPA:17561 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0001896 ! part of medulla oblongata @@ -41677,6 +64037,9 @@ relationship: RO:0002202 UBERON:0009578 ! myelencephalon sulcus limitans [Term] id: UBERON:0009577 name: metencephalon sulcus limitans +def: "A sulcus limitans of neural tube that is part of a future metencephalon." [OBOL:automatic] +xref: EHDAA2:0001161 +xref: EMAPA:17567 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0010092 ! part of future metencephalon @@ -41685,6 +64048,8 @@ relationship: BFO:0000050 UBERON:0010092 ! part of future metencephalon [Term] id: UBERON:0009578 name: myelencephalon sulcus limitans +def: "A sulcus limitans of neural tube that is part of a future myelencephalon." [OBOL:automatic] +xref: EHDAA2:0001945 is_a: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: UBERON:0005478 ! sulcus limitans of neural tube intersection_of: BFO:0000050 UBERON:0010096 ! part of future myelencephalon @@ -41693,6 +64058,9 @@ relationship: BFO:0000050 UBERON:0010096 ! part of future myelencephalon [Term] id: UBERON:0009581 name: midbrain mantle layer +xref: EHDAA2:0001172 +xref: EMAPA:16977 +xref: VHOG:0000910 is_a: UBERON:0004061 ! neural tube mantle layer intersection_of: UBERON:0004061 ! neural tube mantle layer intersection_of: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain @@ -41701,6 +64069,8 @@ relationship: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain [Term] id: UBERON:0009583 name: spinal cord mantle layer +xref: EMAPA:17580 +xref: VHOG:0000911 is_a: UBERON:0004061 ! neural tube mantle layer intersection_of: UBERON:0004061 ! neural tube mantle layer intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord @@ -41709,6 +64079,9 @@ relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord [Term] id: UBERON:0009584 name: 1st arch mandibular mesenchyme +def: "Mesenchyme that is part of a 1st arch mandibular component." [OBOL:automatic] +xref: EHDAA2:0000034 +xref: EMAPA:16385 is_a: UBERON:0010042 ! 1st arch mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0007237 ! part of 1st arch mandibular component @@ -41717,6 +64090,10 @@ relationship: BFO:0000050 UBERON:0007237 ! part of 1st arch mandibular component [Term] id: UBERON:0009602 name: left lung associated mesenchyme +def: "Mesenchyme that is part of a developing left lung." [OBOL:automatic] +xref: EHDAA2:0000944 +xref: EMAPA:16730 +xref: EMAPA:17654 is_a: UBERON:0004883 ! lung mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002168 ! part of left lung @@ -41725,6 +64102,9 @@ relationship: BFO:0000050 UBERON:0002168 ! part of left lung [Term] id: UBERON:0009603 name: right lung associated mesenchyme +def: "Mesenchyme that is part of a developing right lung." [OBOL:automatic] +xref: EHDAA2:0001739 +xref: EMAPA:17662 is_a: UBERON:0004883 ! lung mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0002167 ! part of right lung @@ -41733,6 +64113,9 @@ relationship: BFO:0000050 UBERON:0002167 ! part of right lung [Term] id: UBERON:0009611 name: midbrain neural plate +def: "A neural plate that develops_from a presumptive midbrain." [OBOL:automatic] +xref: TAO:0007019 +xref: ZFA:0007019 is_a: UBERON:0003075 ! neural plate relationship: BFO:0000050 UBERON:0003056 ! part of pre-chordal neural plate relationship: RO:0002202 UBERON:0009616 ! presumptive midbrain @@ -41740,6 +64123,9 @@ relationship: RO:0002202 UBERON:0009616 ! presumptive midbrain [Term] id: UBERON:0009614 name: hindbrain neural plate +def: "A neural plate that develops_from a presumptive hindbrain." [OBOL:automatic] +xref: TAO:0007022 +xref: ZFA:0007022 is_a: UBERON:0003075 ! neural plate relationship: BFO:0000050 UBERON:0003057 ! part of chordal neural plate relationship: RO:0002202 UBERON:0007277 ! presumptive hindbrain @@ -41747,6 +64133,8 @@ relationship: RO:0002202 UBERON:0007277 ! presumptive hindbrain [Term] id: UBERON:0009615 name: midbrain hindbrain boundary neural plate +xref: TAO:0007044 +xref: ZFA:0007044 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0003075 ! part of neural plate relationship: RO:0002495 UBERON:0007281 ! presumptive midbrain hindbrain boundary @@ -41754,6 +64142,14 @@ relationship: RO:0002495 UBERON:0007281 ! presumptive midbrain hindbrain boundar [Term] id: UBERON:0009616 name: presumptive midbrain +def: "A presumptive structure that has the potential to develop into a midbrain." [OBOL:automatic] +xref: BAMS:MES +xref: EFO:0003432 +xref: EHDAA2:0000615 +xref: EMAPA:16140 +xref: TAO:0000148 +xref: Wikipedia:Mesencephalon +xref: ZFA:0000148 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001891 ! midbrain @@ -41765,6 +64161,10 @@ relationship: RO:0002387 UBERON:0001891 ! midbrain [Term] id: UBERON:0009617 name: head paraxial mesoderm +def: "Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles." [PMID:21610022] +xref: EHDAA2:0000736 +xref: EHDAA:364 +xref: EMAPA:16171 is_a: UBERON:0005253 ! head mesenchyme relationship: BFO:0000050 UBERON:0003077 ! part of paraxial mesoderm relationship: BFO:0000050 UBERON:0005253 ! part of head mesenchyme @@ -41772,19 +64172,36 @@ relationship: BFO:0000050 UBERON:0005253 ! part of head mesenchyme [Term] id: UBERON:0009618 name: trunk paraxial mesoderm +xref: EHDAA2:0002094 is_a: UBERON:0005256 ! trunk mesenchyme relationship: BFO:0000050 UBERON:0003077 ! part of paraxial mesoderm relationship: BFO:0000050 UBERON:0005256 ! part of trunk mesenchyme +[Term] +id: UBERON:0009621 +name: tail somite +def: "A somite that is part of a tail." [OBOL:automatic] +xref: AAO:0010383 +xref: EMAPA:16860 +xref: XAO:0003143 +is_a: UBERON:0002329 ! somite +intersection_of: UBERON:0002329 ! somite +intersection_of: BFO:0000050 UBERON:0002415 ! part of tail +relationship: BFO:0000050 UBERON:0002415 ! part of tail + [Term] id: UBERON:0009644 name: trachea non-cartilage connective tissue +xref: EMAPA:35878 +xref: MA:0001859 is_a: UBERON:0003571 ! trachea connective tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0009652 name: bronchus basement membrane +def: "A basement membrane that is part of a bronchus." [OBOL:automatic] +xref: MA:0001832 +xref: NCIT:C49208 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0015329 ! respiratory system basement membrane intersection_of: UBERON:0005769 ! basement membrane of epithelium @@ -41794,6 +64211,9 @@ relationship: BFO:0000050 UBERON:0002031 ! part of epithelium of bronchus [Term] id: UBERON:0009653 name: trachea basement membrane +def: "A basement membrane that is part of a trachea." [OBOL:automatic] +xref: MA:0001854 +xref: NCIT:C49302 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0015329 ! respiratory system basement membrane intersection_of: UBERON:0005769 ! basement membrane of epithelium @@ -41804,6 +64224,8 @@ relationship: BFO:0000050 UBERON:0009644 ! part of trachea non-cartilage connect [Term] id: UBERON:0009657 name: artery of lip +xref: MA:0001987 +xref: NCIT:C52947 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002178 UBERON:0001833 ! lip @@ -41812,6 +64234,10 @@ relationship: RO:0002178 UBERON:0001833 ! lip [Term] id: UBERON:0009661 name: midbrain nucleus +def: "Nucleus located in the midbrain." [ZFIN:curator] +xref: SCTID:279285003 +xref: TAO:0002209 +xref: ZFA:0001665 is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain @@ -41820,14 +64246,83 @@ relationship: BFO:0000050 UBERON:0001891 ! part of midbrain [Term] id: UBERON:0009662 name: hindbrain nucleus +def: "Nucleus located within the hindbrain." [ZFIN:curator] +xref: TAO:0002177 +xref: ZFA:0001658 is_a: UBERON:0002308 ! nucleus of brain intersection_of: UBERON:0002308 ! nucleus of brain intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain +[Term] +id: UBERON:0009664 +name: gut mesentery +xref: EHDAA2:0004566 +xref: EMAPA:32911 +xref: MA:0003203 +is_a: UBERON:0002095 ! mesentery +relationship: RO:0001025 UBERON:0001179 ! peritoneal cavity + +[Term] +id: UBERON:0009669 +name: embryonic cloacal lumen +def: "An anatomical space that surrounded_by a embryonic cloaca." [OBOL:automatic] +xref: EHDAA2:0004586 +is_a: UBERON:0012463 ! cloacal lumen +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0000163 ! embryonic cloaca +relationship: BFO:0000050 UBERON:0000163 ! part of embryonic cloaca +relationship: RO:0002219 UBERON:0009846 ! embryonic cloacal epithelium +relationship: RO:0002572 UBERON:0000163 ! embryonic cloaca + +[Term] +id: UBERON:0009670 +name: rectal lumen +def: "An anatomical space that surrounded_by a rectum." [OBOL:automatic] +xref: EHDAA2:0004587 +xref: EMAPA:18388 +xref: FMA:14598 +xref: SCTID:259740004 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0001052 ! rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0012465 ! part of lumen of terminal part of digestive tract +relationship: RO:0002202 UBERON:0009669 ! embryonic cloacal lumen +relationship: RO:0002572 UBERON:0001052 ! rectum + +[Term] +id: UBERON:0009708 +name: dorsal pancreas +xref: EHDAA2:0001371 +is_a: UBERON:0002365 ! exocrine gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005177 ! trunk region element +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: RO:0002202 UBERON:0010375 ! pancreas dorsal primordium +relationship: RO:0002254 UBERON:0003923 ! dorsal pancreatic bud + +[Term] +id: UBERON:0009709 +name: ventral pancreas +xref: EHDAA2:0001393 +is_a: UBERON:0002365 ! exocrine gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005177 ! trunk region element +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: RO:0002202 UBERON:0010376 ! pancreas ventral primordium +relationship: RO:0002254 UBERON:0003924 ! ventral pancreatic bud + [Term] id: UBERON:0009712 name: endocardium of right ventricle +def: "Any endocardium that is part of the right ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0002188 +xref: EMAPA:17341 +xref: FMA:9536 +xref: NCIT:C102343 +xref: SCTID:8911002 +xref: VHOG:0001235 is_a: UBERON:0001081 ! endocardium of ventricle intersection_of: UBERON:0001081 ! endocardium of ventricle intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle @@ -41838,6 +64333,12 @@ relationship: RO:0002371 UBERON:0006567 ! right ventricle myocardium [Term] id: UBERON:0009713 name: endocardium of left ventricle +def: "Any endocardium that is part of the left ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0002182 +xref: EMAPA:17338 +xref: FMA:9559 +xref: SCTID:191004004 +xref: VHOG:0001233 is_a: UBERON:0001081 ! endocardium of ventricle intersection_of: UBERON:0001081 ! endocardium of ventricle intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle @@ -41847,6 +64348,7 @@ relationship: RO:0002371 UBERON:0006566 ! left ventricle myocardium [Term] id: UBERON:0009715 name: stomodeal lumen +def: "An anatomical cavity that surrounded_by a stomodeum." [OBOL:automatic] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000930 ! stomodeum @@ -41855,6 +64357,9 @@ relationship: RO:0002572 UBERON:0000930 ! stomodeum [Term] id: UBERON:0009722 name: entire pharyngeal arch endoderm +xref: EHDAA2:0004621 +xref: EMAPA:32754 +xref: FMA:293087 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0015833 ! foregut epithelium @@ -41864,15 +64369,31 @@ relationship: BFO:0000050 UBERON:0008814 ! part of pharyngeal arch system [Term] id: UBERON:0009751 name: cardiac mesenchyme +def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures." [MP:0011264] +xref: EHDAA2:0004162 +xref: EMAPA:36438 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart +[Term] +id: UBERON:0009752 +name: pancreas mesenchyme +def: "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas." [MP:0011265] +xref: EFO:0002557 +xref: EMAPA:26220 +is_a: UBERON:0003104 ! mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: UBERON:0009758 name: abdominal ganglion +def: "A ganglion that is part of a abdominal segment of trunk." [OBOL:automatic] +xref: SCTID:280508003 is_a: UBERON:0007134 ! trunk ganglion intersection_of: UBERON:0000045 ! ganglion intersection_of: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk @@ -41881,6 +64402,10 @@ relationship: BFO:0000050 UBERON:0002417 ! part of abdominal segment of trunk [Term] id: UBERON:0009778 name: pleural sac +def: "A serous sac that has the pleura and the pleural cavity as parts." [https://github.com/obophenotype/uberon/issues/86] +xref: EHDAA2:0004737 +xref: FMA:9690 +xref: SCTID:361996004 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0005906 ! serous sac is_a: UBERON:0015212 ! lateral structure @@ -41895,6 +64420,9 @@ relationship: BSPO:0000126 UBERON:0001004 ! respiratory system [Term] id: UBERON:0009842 name: glandular acinus +def: "The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form." [Wikipedia:Acinus] +xref: FMA:55588 +xref: Wikipedia:Acinus is_a: UBERON:0034922 ! cell cluster intersection_of: UBERON:0034922 ! cell cluster intersection_of: BFO:0000050 UBERON:0002530 ! part of gland @@ -41904,9 +64432,24 @@ relationship: BFO:0000050 UBERON:0002530 ! part of gland relationship: BFO:0000051 CL:0000151 ! has part secretory cell relationship: RO:0000086 PATO:0002422 +[Term] +id: UBERON:0009846 +name: embryonic cloacal epithelium +def: "An epithelium that is part of a embryonic cloaca." [OBOL:automatic] +xref: EHDAA2:0004585 +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0009521 ! anal membrane endodermal component +is_a: UBERON:0012481 ! cloacal epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000163 ! part of embryonic cloaca +relationship: BFO:0000050 UBERON:0000163 ! part of embryonic cloaca +relationship: BFO:0000050 UBERON:0003929 ! part of digestive tract epithelium +relationship: RO:0002202 UBERON:0003353 ! epithelium of hindgut + [Term] id: UBERON:0009854 name: digestive tract diverticulum +def: "Branch or outpocketing of the digestive tract." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0009856 ! sac intersection_of: UBERON:0009856 ! sac @@ -41915,6 +64458,7 @@ intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: UBERON:0009856 name: sac +xref: galen:Diverticulum is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0000086 PATO:0001987 @@ -41923,6 +64467,12 @@ relationship: RO:0000086 PATO:0001987 [Term] id: UBERON:0009870 name: zone of stomach +def: "A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland." [ISBN:0073040584, Wikipedia:Stomach#Sections] +xref: EMAPA:35821 +xref: FMA:14558 +xref: MA:0002561 +xref: SCTID:245415005 +xref: Wikipedia:Stomach#Sections is_a: UBERON:0004921 ! subdivision of digestive tract is_a: UBERON:0034944 ! zone of organ intersection_of: UBERON:0034944 ! zone of organ @@ -41932,6 +64482,9 @@ relationship: BFO:0000050 UBERON:0000945 ! part of stomach [Term] id: UBERON:0009881 name: anterior lateral plate mesoderm +xref: EFO:0003704 +xref: TAO:0005041 +xref: ZFA:0005041 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm @@ -41939,6 +64492,8 @@ relationship: BFO:0000050 UBERON:0003081 ! part of lateral plate mesoderm [Term] id: UBERON:0009889 name: secondary heart field +def: "A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." [GO:0003139, GOC:mtg_heart, GOC:rl] +xref: XAO:0004186 is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -41951,6 +64506,9 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0009891 name: facial mesenchyme +def: "Mesenchyme that is part of a developing face." [OBOL:automatic] +xref: EMAPA:35337 +xref: FMA:302884 is_a: UBERON:0005253 ! head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0001456 ! part of face @@ -41959,16 +64517,24 @@ relationship: BFO:0000050 UBERON:0001456 ! part of face [Term] id: UBERON:0009911 name: lobule +xref: FMA:45737 +xref: NCIT:C12990 is_a: UBERON:0000063 ! organ subunit [Term] id: UBERON:0009912 name: anatomical lobe +def: "A portion of an organ, such as the liver, lung, breast, or brain." [ncithesaurus:Lobe] +xref: FMA:45728 +xref: NCIT:C13393 +xref: UMLS:C0796494 is_a: UBERON:0000063 ! organ subunit [Term] id: UBERON:0009920 name: optic neural crest +xref: EHDAA2:0001315 +xref: EHDAA:1122 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest is_a: UBERON:0007530 ! migrating mesenchyme population relationship: BFO:0000050 UBERON:0007213 ! part of mesenchyme derived from head neural crest @@ -41976,6 +64542,8 @@ relationship: BFO:0000050 UBERON:0007213 ! part of mesenchyme derived from head [Term] id: UBERON:0009953 name: post-embryonic organism +def: "A multicellular organism that existence_starts_with a post-embryonic stage." [OBOL:automatic] +xref: MA:0002405 is_a: UBERON:0000468 ! multicellular organism intersection_of: UBERON:0000468 ! multicellular organism intersection_of: RO:0002489 UBERON:0000092 ! post-embryonic stage @@ -41984,6 +64552,12 @@ relationship: RO:0002489 UBERON:0000092 ! post-embryonic stage [Term] id: UBERON:0009955 name: neurogenic placode +def: "Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia." [http://orcid.org/0000-0002-6601-2165, PMID:11523831] +xref: EFO:0003460 +xref: TAO:0001309 +xref: Wikipedia:Neurogenic_placodes +xref: XAO:0004620 +xref: ZFA:0001309 is_a: UBERON:0002546 ! cranial placode intersection_of: UBERON:0005085 ! ectodermal placode intersection_of: RO:0002385 CL:0000540 ! neuron @@ -41995,21 +64569,35 @@ relationship: RO:0002385 CL:0000540 ! neuron relationship: RO:0002385 UBERON:0001714 ! cranial ganglion relationship: RO:0002385 UBERON:0001785 ! cranial nerve +[Term] +id: UBERON:0009970 +name: epithelium of pancreatic duct +def: "An epithelium that is part of a pancreatic duct." [OBOL:automatic] +xref: EFO:0002556 +xref: FMA:67681 +is_a: UBERON:0010371 ! ecto-epithelium +is_a: UBERON:0013697 ! exocrine pancreas epithelium +is_a: UBERON:0034969 ! epithelial layer of duct +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0007329 ! part of pancreatic duct +relationship: BFO:0000050 UBERON:0007329 ! part of pancreatic duct + [Term] id: UBERON:0010000 name: multicellular anatomical structure +def: "An anatomical structure that has more than one cell as a part." [CARO:0010000] +xref: CARO:0010000 is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0000086 PATO:0001993 relationship: BFO:0000051 CL:0000000 ! has part cell relationship: RO:0000086 PATO:0001993 -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0010009 name: aggregate regional part of brain +def: "A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]." [NLXANAT:20090509] +xref: NLXANAT:20090509 is_a: UBERON:0034923 ! disconnected anatomical group intersection_of: UBERON:0034923 ! disconnected anatomical group intersection_of: BFO:0000050 UBERON:0000955 ! part of brain @@ -42020,6 +64608,10 @@ relationship: RO:0002351 UBERON:0002616 ! regional part of brain [Term] id: UBERON:0010031 name: 6th arch mesenchyme +def: "Mesenchyme that is part of a pharyngeal arch 6." [OBOL:automatic] +xref: EHDAA2:0004076 +xref: EMAPA:32765 +xref: FMA:318209 is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 @@ -42028,6 +64620,10 @@ relationship: BFO:0000050 UBERON:0003117 ! part of pharyngeal arch 6 [Term] id: UBERON:0010039 name: food storage organ +def: "An organ of the digestive tract that is capable of retaining and storing food." [https://orcid.org/0000-0002-6601-2165] +xref: BSA:0000123 +xref: TADS:0000172 +xref: TGMA:0001041 is_a: UBERON:0013765 ! digestive system element relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system @@ -42035,14 +64631,31 @@ relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointe [Term] id: UBERON:0010042 name: 1st arch mesenchyme +def: "Mesenchyme that is part of a pharyngeal arch 1." [OBOL:automatic] +xref: EMAPA:16128 is_a: UBERON:0009494 ! pharyngeal arch mesenchymal region intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 relationship: BFO:0000050 UBERON:0004362 ! part of pharyngeal arch 1 +[Term] +id: UBERON:0010045 +name: 1st arch maxillary mesenchyme +def: "Mesenchyme that is part of a 1st arch maxillary component." [OBOL:automatic] +xref: EHDAA2:0000041 +xref: EMAPA:16391 +is_a: UBERON:0010042 ! 1st arch mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0007238 ! part of 1st arch maxillary component +relationship: BFO:0000050 UBERON:0007238 ! part of 1st arch maxillary component + [Term] id: UBERON:0010046 name: entire pharyngeal arch associated mesenchyme +def: "The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells." [https://orcid.org/0000-0002-6601-2165, XAO:0004524] +xref: EHDAA2:0001459 +xref: EMAPA:16550 +xref: XAO:0004524 is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue relationship: BFO:0000050 UBERON:0008814 ! part of pharyngeal arch system @@ -42051,6 +64664,12 @@ relationship: RO:0002254 UBERON:0003099 ! cranial neural crest [Term] id: UBERON:0010047 name: oral gland +def: "Gland of the epithelium lining the oral cavity. The most common are the salivary glands." [ISBN:0073040584] +xref: EHDAA2:0001327 +xref: EHDAA:2181 +xref: EMAPA:16572 +xref: EMAPA:16723 +xref: VHOG:0000652 is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003408 ! gland of digestive tract intersection_of: UBERON:0002530 ! gland @@ -42060,11 +64679,30 @@ relationship: BFO:0000050 UBERON:0000165 ! part of mouth [Term] id: UBERON:0010077 name: cuboidal epithelium +def: "An epithelium consisting of cuboidal epithelial cells." [Wikipedia:Cuboidal_epithelium] +xref: NCIT:C32415 +xref: Wikipedia:Cuboidal_epithelium is_a: UBERON:0000483 ! epithelium +[Term] +id: UBERON:0010081 +name: future common hepatic duct +def: "An extrahepatic bile duct that has the potential to develop into a common hepatic duct." [OBOL:automatic] +xref: EHDAA2:0000595 +is_a: UBERON:0003703 ! extrahepatic bile duct +is_a: UBERON:0003914 ! epithelial tube +is_a: UBERON:0005911 ! endo-epithelium +is_a: UBERON:0034932 ! epithelium of biliary system +intersection_of: UBERON:0003703 ! extrahepatic bile duct +intersection_of: RO:0002387 UBERON:0001175 ! common hepatic duct +relationship: RO:0002202 UBERON:0005604 ! extrahepatic part of hepatic duct +relationship: RO:0002387 UBERON:0001175 ! common hepatic duct + [Term] id: UBERON:0010083 name: future dermis +def: "Mesenchyme that has the potential to develop into a dermis." [OBOL:automatic] +xref: EHDAA2:0000598 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002387 UBERON:0002067 ! dermis @@ -42076,6 +64714,8 @@ relationship: RO:0002387 UBERON:0002067 ! dermis [Term] id: UBERON:0010084 name: future diaphragm +def: "A structure that will develop into a diaphragm." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0000599 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001103 ! diaphragm @@ -42087,6 +64727,8 @@ relationship: RO:0002387 UBERON:0001103 ! diaphragm [Term] id: UBERON:0010092 name: future metencephalon +def: "A developing anatomical structure that has the potential to develop into a metencephalon." [OBOL:automatic] +xref: EHDAA2:0000623 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001895 ! metencephalon @@ -42096,6 +64738,8 @@ relationship: RO:0002387 UBERON:0001895 ! metencephalon [Term] id: UBERON:0010096 name: future myelencephalon +def: "A developing anatomical structure that has the potential to develop into a myelencephalon." [OBOL:automatic] +xref: EHDAA2:0000640 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0005290 ! myelencephalon @@ -42105,6 +64749,8 @@ relationship: RO:0002387 UBERON:0005290 ! myelencephalon [Term] id: UBERON:0010125 name: future superior salivatory nucleus +def: "A gray matter that has the potential to develop into a superior salivatory nucleus." [OBOL:automatic] +xref: EHDAA2:0004644 is_a: UBERON:0002020 ! gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: RO:0002387 UBERON:0002149 ! superior salivatory nucleus @@ -42113,30 +64759,73 @@ relationship: RO:0002387 UBERON:0002149 ! superior salivatory nucleus [Term] id: UBERON:0010131 name: conducting tissue of heart +def: "Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0004528 +xref: FMA:83378 is_a: UBERON:0001133 ! cardiac muscle tissue [Term] id: UBERON:0010136 name: epithelial sheet +def: "An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GO:0002011] is_a: UBERON:0000483 ! epithelium +[Term] +id: UBERON:0010152 +name: skin mucus +def: "A mucous secretion that is produced by glands in the epidermis." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0000912 ! mucus +intersection_of: UBERON:0000912 ! mucus +intersection_of: RO:0003001 UBERON:0004790 ! produced by skin mucous gland +relationship: RO:0003001 UBERON:0004790 ! produced by skin mucous gland + [Term] id: UBERON:0010161 name: lumen of blood vessel +def: "An anatomical cavity that surrounded_by a blood vessel." [OBOL:automatic] +xref: FMA:312610 +xref: SCTID:91747007 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001981 ! blood vessel relationship: BFO:0000050 UBERON:0001981 ! part of blood vessel relationship: RO:0002572 UBERON:0001981 ! blood vessel +[Term] +id: UBERON:0010162 +name: post-anal tail tip +def: "The distal end of the tail." [http://orcid.org/0000-0002-6601-2165] +xref: MA:0002848 +xref: XAO:0004057 +is_a: UBERON:0011676 ! subdivision of organism along main body axis +intersection_of: UBERON:0011676 ! subdivision of organism along main body axis +intersection_of: BSPO:0001108 UBERON:0007812 ! post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BSPO:0001108 UBERON:0007812 ! post-anal tail + +[Term] +id: UBERON:0010183 +name: liver trabecula +def: "A trabecula that is part of a liver." [GO:0060344, OBOL:automatic] +is_a: UBERON:0000440 ! trabecula +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000440 ! trabecula +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: UBERON:0010188 name: protuberance +def: "A roughly circular bulge in a surface." [EHDAA2:0003250] +xref: AEO:0000205 +xref: EHDAA2:0003250 +xref: FMA:82506 is_a: UBERON:0034944 ! zone of organ [Term] id: UBERON:0010191 name: aortic system +xref: EHDAA2:0004512 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0004571 ! part of systemic arterial system relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -42144,19 +64833,49 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0010192 name: genital artery +def: "One of the laterally paired arteries that supply the gonads." [ISBN:0073040584, Wikipedia:Gonadal_artery] +xref: Wikipedia:Gonadal_artery is_a: UBERON:0012254 ! abdominal aorta artery intersection_of: UBERON:0004573 ! systemic artery intersection_of: RO:0002178 UBERON:0000991 ! gonad relationship: RO:0002178 UBERON:0000991 ! gonad +[Term] +id: UBERON:0010194 +name: hepatic portal system +def: "A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver." [ISBN:0073040584] +xref: AAO:0010225 +is_a: UBERON:0005806 ! portal system +relationship: RO:0002176 UBERON:0001555 ! digestive tract +relationship: RO:0002176 UBERON:0002107 ! liver + [Term] id: UBERON:0010199 name: bona-fide anatomical boundary +def: "An anatomical boundary that corresponds to some physical discontinuity." [CARO:0001004] +comment: One might argue that all boundaries are actually fiat in the sense that there must be some fiat element at a fine enough scale of granularity. This ontology choses to ignore this issue as below the level of granularity relevant to anatomy. (DOS121102) +xref: CARO:0001004 is_a: UBERON:0000466 ! immaterial anatomical entity +[Term] +id: UBERON:0010204 +name: tail vasculature +def: "A vasculature that is part of a post-anal tail." [OBOL:automatic] +xref: TAO:0005037 +xref: XAO:0004151 +xref: ZFA:0005037 +is_a: UBERON:0002049 ! vasculature +intersection_of: UBERON:0002049 ! vasculature +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:0010227 name: future cardiac atrium +def: "Multi-tissue structure that is part of the heart tube and will become the cardiac atrium." [ZFA:0001718] +xref: FMA:71005 +xref: TAO:0002228 +xref: ZFA:0001718 is_a: UBERON:0006598 ! presumptive structure relationship: BFO:0000050 UBERON:0004141 ! part of heart tube relationship: RO:0002387 UBERON:0002081 ! cardiac atrium @@ -42164,6 +64883,12 @@ relationship: RO:0002387 UBERON:0002081 ! cardiac atrium [Term] id: UBERON:0010230 name: eyeball of camera-type eye +def: "The core globe-shaped component of the camera-type eye." [UBERON:cjm] +xref: FMA:12513 +xref: MIAA:0000283 +xref: SCTID:244486005 +xref: VHOG:0001616 +xref: Wikipedia:Globe_(human_eye) is_a: UBERON:0000020 ! sense organ is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye @@ -42172,6 +64897,10 @@ relationship: RO:0002433 UBERON:0000019 ! camera-type eye [Term] id: UBERON:0010243 name: merocrine gland +def: "An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged." [MGI:anna, MP:0013544, Wikipedia:Merocrine] +xref: BTO:0002324 +xref: MA:0003041 +xref: Wikipedia:Merocrine is_a: UBERON:0002365 ! exocrine gland intersection_of: UBERON:0002365 ! exocrine gland intersection_of: RO:0002215 GO:0006887 ! capable of exocytosis @@ -42180,6 +64909,8 @@ relationship: RO:0002215 GO:0006887 ! capable of exocytosis [Term] id: UBERON:0010252 name: 1st arch mandibular mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000037 is_a: UBERON:0009584 ! 1st arch mandibular mesenchyme is_a: UBERON:0010259 ! 1st arch mesenchyme from neural crest intersection_of: UBERON:0003104 ! mesenchyme @@ -42189,9 +64920,26 @@ relationship: BFO:0000050 UBERON:0009584 ! part of 1st arch mandibular mesenchym relationship: BFO:0000050 UBERON:0010258 ! part of mesenchyme from rhombencephalic neural crest relationship: RO:0002202 UBERON:0007098 ! mandibular neural crest +[Term] +id: UBERON:0010253 +name: 1st arch maxillary mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000044 +is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme +is_a: UBERON:0010259 ! 1st arch mesenchyme from neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0010045 ! part of 1st arch maxillary mesenchyme +intersection_of: RO:0002202 UBERON:0002342 ! neural crest +relationship: BFO:0000050 UBERON:0010045 ! part of 1st arch maxillary mesenchyme +relationship: BFO:0000050 UBERON:0010258 ! part of mesenchyme from rhombencephalic neural crest + [Term] id: UBERON:0010256 name: 4th arch mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000098 +xref: EMAPA:16772 +xref: VHOG:0000580 is_a: UBERON:0005691 ! 4th arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest @@ -42204,6 +64952,8 @@ relationship: BFO:0000050 UBERON:0010258 ! part of mesenchyme from rhombencephal [Term] id: UBERON:0010257 name: 6th arch mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004077 is_a: UBERON:0010031 ! 6th arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest @@ -42216,6 +64966,8 @@ relationship: BFO:0000050 UBERON:0010258 ! part of mesenchyme from rhombencephal [Term] id: UBERON:0010258 name: mesenchyme from rhombencephalic neural crest +def: "Mesenchyme that develops_from a rhombencephalon neural crest." [OBOL:automatic] +xref: EHDAA2:0004423 is_a: UBERON:0007213 ! mesenchyme derived from head neural crest intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002202 UBERON:0003852 ! rhombencephalon neural crest @@ -42225,6 +64977,8 @@ relationship: RO:0002202 UBERON:0003852 ! rhombencephalon neural crest [Term] id: UBERON:0010259 name: 1st arch mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme." [OBOL:automatic] +xref: EMAPA:16129 is_a: UBERON:0010042 ! 1st arch mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest is_a: UBERON:0010359 ! pharyngeal arch mesenchyme from neural crest @@ -42233,9 +64987,25 @@ intersection_of: BFO:0000050 UBERON:0010042 ! part of 1st arch mesenchyme intersection_of: RO:0002202 UBERON:0002342 ! neural crest relationship: BFO:0000050 UBERON:0010042 ! part of 1st arch mesenchyme +[Term] +id: UBERON:0010276 +name: space in vertebral column +def: "Any anatomical space that is part of a vertebral column." [OBOL:automatic] +xref: AAO:0000700 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: BFO:0000050 UBERON:0001130 ! part of vertebral column +relationship: BFO:0000050 UBERON:0001130 ! part of vertebral column + [Term] id: UBERON:0010285 name: midbrain basal plate +def: "Portion of tissue that is dorsolateral to the floor plate and part of the midbrain." [ZFA:0000761] +xref: DHBA:12322 +xref: EFO:0003567 +xref: EHDAA2:0004375 +xref: TAO:0000761 +xref: ZFA:0000761 is_a: UBERON:0002020 ! gray matter relationship: BFO:0000050 UBERON:0009581 ! part of midbrain mantle layer relationship: BFO:0000050 UBERON:0010286 ! part of midbrain neural tube @@ -42243,6 +65013,9 @@ relationship: BFO:0000050 UBERON:0010286 ! part of midbrain neural tube [Term] id: UBERON:0010286 name: midbrain neural tube +def: "Portion of neural tube that gives rise to the midbrain." [ZFA:0007039] +xref: TAO:0007039 +xref: ZFA:0007039 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue relationship: BFO:0000050 UBERON:0003080 ! part of anterior neural tube @@ -42250,6 +65023,7 @@ relationship: BFO:0000050 UBERON:0003080 ! part of anterior neural tube [Term] id: UBERON:0010291 name: layer of sclera +xref: Wikipedia:Sclera#Histology is_a: UBERON:0004923 ! organ component layer is_a: UBERON:0010313 ! neural crest-derived structure relationship: BFO:0000050 UBERON:0001773 ! part of sclera @@ -42257,6 +65031,7 @@ relationship: BFO:0000050 UBERON:0001773 ! part of sclera [Term] id: UBERON:0010294 name: scleral endothelium +def: "An endothelium that is part of a sclera." [OBOL:automatic] is_a: UBERON:0001986 ! endothelium is_a: UBERON:0010291 ! layer of sclera is_a: UBERON:0015808 ! eye epithelium @@ -42266,6 +65041,10 @@ intersection_of: BFO:0000050 UBERON:0001773 ! part of sclera [Term] id: UBERON:0010295 name: substantia propria of sclera +def: "A stroma that is part of a sclera." [OBOL:automatic] +xref: FMA:58365 +xref: NCIT:C33652 +xref: SCTID:368851004 is_a: UBERON:0003891 ! stroma is_a: UBERON:0010291 ! layer of sclera intersection_of: UBERON:0003891 ! stroma @@ -42274,6 +65053,7 @@ intersection_of: BFO:0000050 UBERON:0001773 ! part of sclera [Term] id: UBERON:0010299 name: scleral mesenchyme +def: "Mesenchyme surrounding the developing optic cup which develops into the sclera." [https://orcid.org/0000-0002-6601-2165, PMID:16496288] is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: RO:0002387 UBERON:0001773 ! sclera @@ -42283,6 +65063,7 @@ relationship: RO:0002387 UBERON:0001773 ! sclera [Term] id: UBERON:0010303 name: extraembryonic epithelium +def: "An epithelium that is part of a extraembryonic structure." [OBOL:automatic] is_a: UBERON:0000483 ! epithelium is_a: UBERON:0005292 ! extraembryonic tissue intersection_of: UBERON:0000483 ! epithelium @@ -42292,6 +65073,9 @@ relationship: BFO:0000050 UBERON:0000478 ! part of extraembryonic structure [Term] id: UBERON:0010312 name: immature eye +def: "Developing anatomical structure that develops into the eyeball and associated structures." [ZFA:0001678] +xref: TAO:0002201 +xref: ZFA:0001678 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: RO:0002254 UBERON:0003071 ! eye primordium @@ -42301,6 +65085,7 @@ relationship: RO:0002254 UBERON:0003071 ! eye primordium [Term] id: UBERON:0010313 name: neural crest-derived structure +def: "An anatomical structure that develops from the neural crest." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000061 ! anatomical structure @@ -42310,6 +65095,7 @@ relationship: RO:0002202 UBERON:0002342 ! neural crest [Term] id: UBERON:0010314 name: structure with developmental contribution from neural crest +def: "An anatomical structure that has some part that develops from the neural crest." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002254 UBERON:0002342 ! neural crest @@ -42325,6 +65111,7 @@ relationship: RO:0002202 UBERON:0002532 ! epiblast (generic) [Term] id: UBERON:0010321 name: skeletal element of eye region +def: "A skeletal element that is part of a orbital region." [OBOL:automatic] is_a: UBERON:0004765 ! skeletal element is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0004765 ! skeletal element @@ -42335,6 +65122,14 @@ relationship: BFO:0000050 UBERON:0011156 ! part of facial skeleton [Term] id: UBERON:0010323 name: cranial skeletal system +def: "Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000049] +xref: AAO:0000109 +xref: AAO:0000971 +xref: AAO:0010185 +xref: TAO:0000737 +xref: VSAO:0000049 +xref: XAO:0003075 +xref: ZFA:0000737 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0011137 ! part of axial skeletal system relationship: RO:0002160 NCBITaxon:89593 ! Craniata @@ -42342,6 +65137,7 @@ relationship: RO:0002160 NCBITaxon:89593 ! Craniata [Term] id: UBERON:0010329 name: paired limb/fin bud mesenchyme +def: "Mesenchyme that is part of a limb/fin bud." [OBOL:automatic] is_a: UBERON:0010377 ! mesenchyme from somatopleure intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0004357 ! part of paired limb/fin bud @@ -42351,6 +65147,7 @@ relationship: RO:0002202 UBERON:0010377 ! mesenchyme from somatopleure [Term] id: UBERON:0010333 name: extraembryonic membrane mesenchyme +def: "Mesenchyme that is part of a extraembryonic membrane." [OBOL:automatic] is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005292 ! extraembryonic tissue @@ -42359,9 +65156,37 @@ intersection_of: BFO:0000050 UBERON:0005631 ! part of extraembryonic membrane relationship: BFO:0000050 UBERON:0005631 ! part of extraembryonic membrane relationship: RO:0002202 UBERON:0005728 ! extraembryonic mesoderm +[Term] +id: UBERON:0010334 +name: maxillary process mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004601 +is_a: UBERON:0009526 ! maxillary process mesenchyme +is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0009526 ! part of maxillary process mesenchyme +intersection_of: RO:0002202 UBERON:0002342 ! neural crest +relationship: BFO:0000050 UBERON:0009526 ! part of maxillary process mesenchyme +relationship: RO:0002202 UBERON:0010253 ! 1st arch maxillary mesenchyme from neural crest + +[Term] +id: UBERON:0010335 +name: maxillary process mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004602 +is_a: UBERON:0004120 ! mesoderm-derived structure +is_a: UBERON:0009526 ! maxillary process mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0009526 ! part of maxillary process mesenchyme +intersection_of: RO:0002202 UBERON:0006904 ! head mesenchyme from mesoderm +relationship: BFO:0000050 UBERON:0009526 ! part of maxillary process mesenchyme +relationship: RO:0002202 UBERON:0010338 ! 1st arch maxillary mesenchyme from head mesenchyme + [Term] id: UBERON:0010336 name: mandibular process mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004603 is_a: UBERON:0006905 ! mandibular process mesenchyme is_a: UBERON:0010258 ! mesenchyme from rhombencephalic neural crest intersection_of: UBERON:0003104 ! mesenchyme @@ -42373,6 +65198,8 @@ relationship: RO:0002202 UBERON:0010252 ! 1st arch mandibular mesenchyme from ne [Term] id: UBERON:0010337 name: mandibular process mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004604 is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0006905 ! mandibular process mesenchyme intersection_of: UBERON:0003104 ! mesenchyme @@ -42381,9 +65208,23 @@ intersection_of: RO:0002202 UBERON:0006904 ! head mesenchyme from mesoderm relationship: BFO:0000050 UBERON:0006905 ! part of mandibular process mesenchyme relationship: RO:0002202 UBERON:0010339 ! 1st arch mandibular mesenchyme from head mesenchyme +[Term] +id: UBERON:0010338 +name: 1st arch maxillary mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000043 +is_a: UBERON:0010045 ! 1st arch maxillary mesenchyme +is_a: UBERON:0010341 ! 1st arch mesenchyme from head mesenchyme +intersection_of: UBERON:0003104 ! mesenchyme +intersection_of: BFO:0000050 UBERON:0010045 ! part of 1st arch maxillary mesenchyme +intersection_of: RO:0002202 UBERON:0006904 ! head mesenchyme from mesoderm +relationship: BFO:0000050 UBERON:0010045 ! part of 1st arch maxillary mesenchyme + [Term] id: UBERON:0010339 name: 1st arch mandibular mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000036 is_a: UBERON:0009584 ! 1st arch mandibular mesenchyme is_a: UBERON:0010341 ! 1st arch mesenchyme from head mesenchyme intersection_of: UBERON:0003104 ! mesenchyme @@ -42394,6 +65235,8 @@ relationship: BFO:0000050 UBERON:0009584 ! part of 1st arch mandibular mesenchym [Term] id: UBERON:0010341 name: 1st arch mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme." [OBOL:automatic] +xref: EMAPA:16130 is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0010042 ! 1st arch mesenchyme is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme @@ -42405,6 +65248,9 @@ relationship: BFO:0000050 UBERON:0010042 ! part of 1st arch mesenchyme [Term] id: UBERON:0010345 name: 4th arch mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme." [OBOL:automatic] +xref: EHDAA2:0000097 +xref: EMAPA:16771 is_a: UBERON:0005691 ! 4th arch mesenchyme is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme @@ -42416,6 +65262,8 @@ relationship: BFO:0000050 UBERON:0005691 ! part of 4th arch mesenchyme [Term] id: UBERON:0010347 name: 6th arch mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme." [OBOL:automatic] +xref: EHDAA2:0004078 is_a: UBERON:0006904 ! head mesenchyme from mesoderm is_a: UBERON:0010031 ! 6th arch mesenchyme is_a: UBERON:0010360 ! pharyngeal arch mesenchyme from head mesenchyme @@ -42427,6 +65275,8 @@ relationship: BFO:0000050 UBERON:0010031 ! part of 6th arch mesenchyme [Term] id: UBERON:0010359 name: pharyngeal arch mesenchyme from neural crest +def: "Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme." [OBOL:automatic] +comment: Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0014387 ! mesenchyme derived from neural crest intersection_of: UBERON:0003104 ! mesenchyme @@ -42437,6 +65287,8 @@ relationship: BFO:0000050 UBERON:0010046 ! part of entire pharyngeal arch associ [Term] id: UBERON:0010360 name: pharyngeal arch mesenchyme from head mesenchyme +def: "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme." [OBOL:automatic] +comment: Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -42449,6 +65301,10 @@ relationship: RO:0002202 UBERON:0006904 ! head mesenchyme from mesoderm [Term] id: UBERON:0010362 name: endoskeleton +def: "Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000037] +xref: VSAO:0000037 +xref: Wikipedia:Endoskeleton +xref: XAO:0004026 is_a: UBERON:0010912 ! subdivision of skeleton relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002473 UBERON:0010522 ! replacement element @@ -42456,17 +65312,28 @@ relationship: RO:0002473 UBERON:0010522 ! replacement element [Term] id: UBERON:0010363 name: endochondral element +def: "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000139] +xref: VSAO:0000139 +xref: XAO:0004017 +xref: ZFA:0005620 is_a: UBERON:0004765 ! skeletal element [Term] id: UBERON:0010364 name: dermal skeleton +def: "Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000035] +comment: This ontology covers metazoa, so we do not use exoskeleton as primary label, as in VSAO +xref: VSAO:0000035 +xref: XAO:0004025 is_a: UBERON:0010912 ! subdivision of skeleton relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0010368 name: pulmonary lobule +def: "The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa." [ncithesaurus:Pulmonary_Lobule] +xref: FMA:75739 +xref: NCIT:C33428 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0009911 ! lobule intersection_of: UBERON:0009911 ! lobule @@ -42476,22 +65343,51 @@ relationship: BFO:0000050 UBERON:8600017 ! part of bronchopulmonary segment [Term] id: UBERON:0010369 name: secondary pulmonary lobule +def: "A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa." [PMID:3259815] +xref: FMA:7414 is_a: UBERON:0010368 ! pulmonary lobule relationship: BFO:0000050 UBERON:0008946 ! part of lung parenchyma -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0010371 name: ecto-epithelium +def: "Epithelium composed of cells that develops from the ectoderm[FMA,modified]." [FMA:69064] +xref: FMA:69064 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000483 ! epithelium intersection_of: RO:0002202 UBERON:0000924 ! ectoderm relationship: RO:0002473 CL:0002077 ! ecto-epithelial cell +[Term] +id: UBERON:0010375 +name: pancreas dorsal primordium +xref: EHDAA2:0001384 +xref: FMA:79793 +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0009708 ! dorsal pancreas +relationship: BFO:0000050 UBERON:0003921 ! part of pancreas primordium +relationship: RO:0002387 UBERON:0009708 ! dorsal pancreas + +[Term] +id: UBERON:0010376 +name: pancreas ventral primordium +xref: EHDAA2:0001387 +xref: FMA:79794 +is_a: UBERON:0001048 ! primordium +is_a: UBERON:0006598 ! presumptive structure +intersection_of: UBERON:0001048 ! primordium +intersection_of: RO:0002387 UBERON:0009709 ! ventral pancreas +relationship: BFO:0000050 UBERON:0003921 ! part of pancreas primordium +relationship: RO:0002387 UBERON:0009709 ! ventral pancreas + [Term] id: UBERON:0010377 name: mesenchyme from somatopleure +def: "Mesenchyme that develops_from a somatopleure." [OBOL:automatic] +xref: EHDAA2:0001120 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue @@ -42504,6 +65400,8 @@ relationship: RO:0002202 UBERON:0004874 ! somatopleure [Term] id: UBERON:0010378 name: mesenchyme from splanchnopleure +def: "Mesenchyme that develops_from a splanchnopleure." [OBOL:automatic] +xref: EHDAA2:0001122 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue is_a: UBERON:0007524 ! dense mesenchyme tissue @@ -42513,9 +65411,41 @@ intersection_of: RO:0002202 UBERON:0004873 ! splanchnopleure relationship: BFO:0000050 UBERON:0009142 ! part of entire embryonic mesenchyme relationship: RO:0002202 UBERON:0004873 ! splanchnopleure +[Term] +id: UBERON:0010399 +name: spleen trabecular artery +def: "One of the branches of the splenic artery[MP]." [MP:0002354, Wikipedia:Trabecular_arteries] +xref: MA:0000759 +xref: NCIT:C49775 +xref: Wikipedia:Trabecular_arteries +is_a: UBERON:0001637 ! artery +is_a: UBERON:0003497 ! abdomen blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen +relationship: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen +relationship: RO:0002252 UBERON:0001194 ! splenic artery +relationship: RO:0002433 UBERON:0002106 ! spleen + +[Term] +id: UBERON:0010400 +name: spleen trabecular vein +def: "One of the veins that feed the splenic vein." [MP:0002228, Wikipedia:Trabecular_veins] +xref: MA:0000760 +xref: NCIT:C49779 +xref: Wikipedia:Trabecular_veins +is_a: UBERON:0013126 ! vein of abdomen +intersection_of: UBERON:0001638 ! vein +intersection_of: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen +relationship: BFO:0000050 UBERON:0001265 ! part of trabecula of spleen +relationship: RO:0002170 UBERON:0003713 ! splenic vein +relationship: RO:0002433 UBERON:0002106 ! spleen + [Term] id: UBERON:0010409 name: ocular surface region +def: "The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms." [MP:0013754] +xref: EMAPA:35336 +xref: MA:0002486 is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye @@ -42524,6 +65454,10 @@ relationship: BSPO:0000108 UBERON:0022288 ! surface of eyeball [Term] id: UBERON:0010427 name: ciliary processes +def: "The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens." [Wikipedia:Ciliary_processes] +xref: FMA:76551 +xref: SCTID:280860001 +xref: Wikipedia:Ciliary_processes is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body @@ -42531,17 +65465,32 @@ relationship: BFO:0000050 UBERON:0001775 ! part of ciliary body [Term] id: UBERON:0010428 name: flat bone +def: "A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow." [Wikipedia:Flat_bone] +comment: Examples: cranium, the ilium, sternum, rib cage, the sacrum and the scapula; the occipital, parietal, frontal, nasal, lacrimal, vomer, scapula, os coxC&, sternum, and ribs +xref: FMA:7476 +xref: galen:FlatBone +xref: NCIT:C32616 +xref: SCTID:332907008 +xref: Wikipedia:Flat_bone is_a: UBERON:0001474 ! bone element relationship: RO:0000086 PATO:0000407 [Term] id: UBERON:0010498 name: pseudostratified columnar epithelium +def: "A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels." [http://medical-dictionary.thefreedictionary.com/pseudostratified+epithelium, Wikipedia:Pseudostratified_columnar_epithelium] +xref: FMA:45572 +xref: NCIT:C33419 +xref: NCIT:C49316 +xref: Wikipedia:Pseudostratified_columnar_epithelium is_a: UBERON:0000485 ! simple columnar epithelium [Term] id: UBERON:0010499 name: pseudostratified ciliated columnar epithelium +def: "Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile." [NCIT:NCIT] +xref: FMA:13146 +xref: NCIT:C13181 is_a: UBERON:0007592 ! ciliated columnar epithelium is_a: UBERON:0010498 ! pseudostratified columnar epithelium intersection_of: UBERON:0010498 ! pseudostratified columnar epithelium @@ -42550,18 +65499,46 @@ intersection_of: BFO:0000051 CL:0000067 ! has part ciliated epithelial cell [Term] id: UBERON:0010522 name: replacement element +def: "Skeletal element that forms as a replacement or substitution of another element or tissue." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000135] +xref: VSAO:0000135 +xref: XAO:0004016 +xref: ZFA:0005624 is_a: UBERON:0004765 ! skeletal element relationship: BFO:0000050 UBERON:0010362 ! part of endoskeleton [Term] id: UBERON:0010523 name: microcirculatory vessel +def: "A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses." [http://orcid.org/0000-0002-6601-2165, MESH:A07.231.432, ZFA:0005251] +xref: MESH:D055806 +xref: TAO:0005251 +xref: ZFA:0005251 is_a: UBERON:0000055 ! vessel relationship: BFO:0000050 UBERON:0002049 ! part of vasculature +[Term] +id: UBERON:0010527 +name: cavity of bone organ +def: "An organ cavity that surrounded_by a bone." [OBOL:automatic] +xref: FMA:24021 +is_a: UBERON:0002558 ! organ cavity +intersection_of: UBERON:0002558 ! organ cavity +intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element +relationship: BFO:0000050 UBERON:0001474 ! part of bone element + +[Term] +id: UBERON:0010528 +name: pneumatic cavity of bone +xref: FMA:24028 +is_a: UBERON:0010527 ! cavity of bone organ +relationship: BFO:0000050 UBERON:0008193 ! part of pneumatized bone + [Term] id: UBERON:0010707 name: appendage girdle complex +def: "An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc)." [https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton, https://orcid.org/0000-0002-6601-2165] +xref: FMA:7182 +xref: VSAO:0000214 is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000468 ! multicellular organism @@ -42571,6 +65548,10 @@ relationship: RO:0002328 GO:0040011 ! locomotion [Term] id: UBERON:0010708 name: pectoral complex +def: "Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle." [VSAO:0000213] +xref: FMA:7183 +xref: SCTID:110716002 +xref: VSAO:0000213 is_a: UBERON:0010707 ! appendage girdle complex intersection_of: UBERON:0010707 ! appendage girdle complex intersection_of: BFO:0000051 UBERON:0001421 ! has part pectoral girdle region @@ -42581,6 +65562,9 @@ relationship: RO:0002551 UBERON:0012475 ! skeleton of pectoral complex [Term] id: UBERON:0010719 name: girdle skeleton +def: "The subdivision of the skeleton of either the pectoral or pelvic girdle." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0010686 +xref: VSAO:0000302 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0007823 ! appendage girdle region @@ -42592,6 +65576,9 @@ relationship: RO:0002576 UBERON:0007823 ! appendage girdle region [Term] id: UBERON:0010740 name: bone of appendage girdle complex +def: "A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle)." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: EMAPA:35494 +xref: MA:0000688 is_a: UBERON:0001474 ! bone element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0010707 ! part of appendage girdle complex @@ -42602,6 +65589,9 @@ relationship: RO:0002433 UBERON:0002091 ! appendicular skeleton [Term] id: UBERON:0010741 name: bone of pectoral complex +def: "A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: EMAPA:35933 +xref: MA:0000612 is_a: UBERON:0010740 ! bone of appendage girdle complex intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex @@ -42610,6 +65600,11 @@ relationship: BFO:0000050 UBERON:0010708 ! part of pectoral complex [Term] id: UBERON:0010891 name: pectoral complex muscle +def: "A muscle of a pectoral girdle, pectoral fin or anterior limb." [https://orcid.org/0000-0002-6601-2165] +xref: AAO:0010687 +xref: EMAPA:32624 +xref: FMA:9621 +xref: MA:0000615 is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex @@ -42618,13 +65613,28 @@ relationship: BFO:0000050 UBERON:0014793 ! part of musculature of pectoral compl [Term] id: UBERON:0010912 name: subdivision of skeleton +def: "Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003] +xref: FMA:23879 +xref: SCTID:129140006 +xref: VSAO:0000042 is_a: UBERON:0011216 ! organ system subdivision relationship: BFO:0000050 UBERON:0000075 ! part of subdivision of skeletal system relationship: BFO:0000050 UBERON:0004288 ! part of skeleton +[Term] +id: UBERON:0010913 +name: vertebral element +def: "Skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, https://github.com/obophenotype/uberon/issues/294, VSAO:0000184] +xref: VHOG:0001143 +xref: VSAO:0000184 +is_a: UBERON:0004765 ! skeletal element +relationship: RO:0002202 UBERON:0003089 ! sclerotome + [Term] id: UBERON:0010959 name: craniocervical muscle +def: "Any muscle organ that is part of either the head or the neck." [http://orcid.org/0000-0002-6601-2165] +xref: NCIT:C32716 is_a: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region @@ -42633,15 +65643,60 @@ relationship: BFO:0000050 UBERON:0008229 ! part of craniocervical region muscula [Term] id: UBERON:0011004 name: pharyngeal arch cartilage +def: "A cartilage element that is part of a splanchnocranium." [OBOL:automatic] +xref: EFO:0003689 +xref: TAO:0001460 +xref: ZFA:0001460 is_a: UBERON:0003933 ! cranial cartilage intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0008895 ! part of splanchnocranium relationship: BFO:0000050 UBERON:0008895 ! part of splanchnocranium relationship: RO:0002202 UBERON:0002539 ! pharyngeal arch +[Term] +id: UBERON:0011085 +name: palatoquadrate arch +def: "The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG]." [https://github.com/obophenotype/uberon/issues/153, VHOG:0000511] +xref: EFO:0003659 +xref: TAO:0001272 +xref: ZFA:0001272 +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010912 ! subdivision of skeleton +relationship: BFO:0000050 UBERON:0003277 ! part of skeleton of upper jaw +relationship: BFO:0000050 UBERON:0008895 ! part of splanchnocranium +relationship: RO:0002202 UBERON:0004362 ! pharyngeal arch 1 + +[Term] +id: UBERON:0011094 +name: vertebra cartilage element +def: "The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, http://orcid.org/0000-0002-6601-2165, VSAO:0000184] +xref: EMAPA:32669 +xref: VHOG:0000584 +is_a: UBERON:0007844 ! cartilage element +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue +relationship: RO:0002202 UBERON:0011095 ! vertebra pre-cartilage condensation +relationship: RO:0002387 UBERON:0002412 ! vertebra + +[Term] +id: UBERON:0011095 +name: vertebra pre-cartilage condensation +def: "The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, http://orcid.org/0000-0002-6601-2165, VSAO:0000184] +xref: EMAPA:32671 +xref: VHOG:0000582 +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: RO:0002473 UBERON:0005866 ! pre-cartilage condensation +relationship: RO:0002387 UBERON:0002412 ! vertebra +relationship: RO:0002473 UBERON:0005866 ! pre-cartilage condensation + [Term] id: UBERON:0011108 name: synovial joint of pectoral girdle +def: "A synovial joint that is part of a pectoral girdle region." [OBOL:automatic] +xref: FMA:35243 +xref: SCTID:303080001 is_a: UBERON:0002217 ! synovial joint is_a: UBERON:0008114 ! joint of girdle intersection_of: UBERON:0002217 ! synovial joint @@ -42652,23 +65707,48 @@ relationship: RO:0002176 UBERON:0007829 ! pectoral girdle bone [Term] id: UBERON:0011134 name: nonsynovial joint +def: "Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis." [FMA:7491] +xref: FMA:7491 is_a: UBERON:0000982 ! skeletal joint [Term] id: UBERON:0011137 name: axial skeletal system +def: "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:7483 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000051 UBERON:0000982 ! has part skeletal joint [Term] id: UBERON:0011138 name: postcranial axial skeletal system +def: "Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints." [https://github.com/obophenotype/uberon/issues/44, https://orcid.org/0000-0002-6601-2165] +xref: FMA:302077 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: RO:0002202 UBERON:0003089 ! sclerotome +[Term] +id: UBERON:0011148 +name: submucosal gland +def: "Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue." [BTO:0003751, Wikipedia:Submucosal_glands] +xref: BTO:0003751 +xref: Wikipedia:Submucosal_glands +is_a: UBERON:0000414 ! mucous gland +intersection_of: UBERON:0000414 ! mucous gland +intersection_of: RO:0001025 UBERON:0000009 ! submucosa +relationship: RO:0001025 UBERON:0000009 ! submucosa +relationship: RO:0002150 UBERON:0003350 ! epithelium of mucosa + [Term] id: UBERON:0011156 name: facial skeleton +def: "Subdivision of skull that consists of the facial bones." [http://www.bartleby.com/107/37.html, https://orcid.org/0000-0002-6601-2165, MP:0005274, Wikipedia:Facial_skeleton] +xref: EHDAA2:0002206 +xref: EHDAA:8361 +xref: EMAPA:18022 +xref: FMA:53673 +xref: MA:0000318 +xref: Wikipedia:Facial_skeleton is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011158 ! primary subdivision of skull relationship: BFO:0000050 UBERON:0001456 ! part of face @@ -42676,6 +65756,8 @@ relationship: BFO:0000050 UBERON:0001456 ! part of face [Term] id: UBERON:0011158 name: primary subdivision of skull +def: "The skull can be divided into two: the neurocranium and the facial skeleton." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:54964 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000050 UBERON:0003129 ! part of skull @@ -42688,15 +65770,77 @@ relationship: BFO:0000050 UBERON:0010323 ! part of cranial skeletal system [Term] id: UBERON:0011164 name: neurocranium bone +def: "A bone that is part of a neurocranium [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:35238 +xref: MA:0001478 +xref: SCTID:120229002 is_a: UBERON:0003457 ! head bone is_a: UBERON:0004766 ! cranial bone intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0001703 ! part of neurocranium relationship: BFO:0000050 UBERON:0001703 ! part of neurocranium +[Term] +id: UBERON:0011171 +name: joint connecting upper and lower jaws +def: "Synovial joint that articulates bones of upper and lower jaw." [http://evolution.berkeley.edu/evolibrary/article/evograms_05, https://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0002217 ! synovial joint +intersection_of: UBERON:0000982 ! skeletal joint +intersection_of: RO:0002176 UBERON:0003277 ! skeleton of upper jaw +intersection_of: RO:0002176 UBERON:0003278 ! skeleton of lower jaw +relationship: RO:0002176 UBERON:0003277 ! skeleton of upper jaw +relationship: RO:0002176 UBERON:0003278 ! skeleton of lower jaw + +[Term] +id: UBERON:0011185 +name: gastrointestinal sphincter +def: "A sphincter muscle that is part of the gastrointestinal system." [OBOL:automatic] +xref: NCIT:C32669 +is_a: UBERON:0004590 ! sphincter muscle +is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system +relationship: BFO:0000050 UBERON:0005409 ! part of alimentary part of gastrointestinal system + +[Term] +id: UBERON:0011189 +name: lamina propria of large intestine +def: "A lamina propria that is part of a large intestine." [OBOL:automatic] +xref: FMA:15654 +xref: NCIT:C49298 +is_a: UBERON:0004780 ! gastrointestinal system lamina propria +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001207 ! part of mucosa of large intestine + +[Term] +id: UBERON:0011198 +name: muscle layer of large intestine +def: "A muscle layer that is part of a large intestine." [OBOL:automatic] +xref: FMA:14971 +xref: NCIT:C32927 +is_a: UBERON:0012367 ! muscle layer of intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000050 UBERON:0001169 ! part of wall of large intestine + +[Term] +id: UBERON:0011201 +name: muscle layer of small intestine +def: "A muscle layer that is part of a small intestine." [OBOL:automatic] +xref: FMA:14932 +xref: NCIT:C33569 +xref: SCTID:362145004 +is_a: UBERON:0012367 ! muscle layer of intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0001168 ! part of wall of small intestine + [Term] id: UBERON:0011215 name: central nervous system cell part cluster +def: "A multi cell part structure that is part of a central nervous system." [OBOL:automatic] +xref: FMA:83143 is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0005162 ! multi cell part structure intersection_of: UBERON:0005162 ! multi cell part structure @@ -42706,16 +65850,18 @@ relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system [Term] id: UBERON:0011216 name: organ system subdivision +def: "A subdivision of an anatomical system." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:67509 +xref: SCTID:91690000 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000467 ! part of anatomical system -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011222 name: intra-ocular muscle +xref: AAO:0010038 +xref: EMAPA:18808 +xref: FMA:49150 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004277 ! eye muscle relationship: BFO:0000050 UBERON:0003386 ! part of smooth muscle of eye @@ -42723,6 +65869,11 @@ relationship: BFO:0000050 UBERON:0003386 ! part of smooth muscle of eye [Term] id: UBERON:0011233 name: synovial membrane of synovial tendon sheath +def: "Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa." [FMA:45087, Wikipedia:Synovial_sheath] +comment: Alternate def: A synovial sheath is a layer of a tendon sheath containing tendons in the hand and foot. They lie internal to the fibrous tendon sheaths. An example is the common synovial sheath for the flexor tendons. [Wikipedia:Synovial_sheath] +xref: BTO:0001823 +xref: FMA:40878 +xref: Wikipedia:Synovial_sheath is_a: UBERON:0007616 ! layer of synovial tissue intersection_of: UBERON:0007616 ! layer of synovial tissue intersection_of: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath @@ -42731,6 +65882,7 @@ relationship: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath [Term] id: UBERON:0011234 name: fibrous membrane of synovial tendon sheath +xref: FMA:40877 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath @@ -42738,9 +65890,21 @@ intersection_of: RO:0002473 UBERON:0011824 ! fibrous connective tissue relationship: RO:0002007 UBERON:0000304 ! bounding layer of tendon sheath relationship: RO:0002473 UBERON:0011824 ! fibrous connective tissue +[Term] +id: UBERON:0011241 +name: ethmoid region +def: "The most anterior region of the braincase. Provides structural support for peripheral olfactory organ." [http://palaeos.com/vertebrates/bones/braincase/ethmoid.html, UBERONREF:0000007] +xref: AAO:0000986 +is_a: UBERON:0034921 ! multi organ part structure +relationship: BFO:0000050 UBERON:0003112 ! part of olfactory region +relationship: RO:0002254 UBERON:0005945 ! neurocranial trabecula + [Term] id: UBERON:0011249 name: appendicular skeletal system +def: "Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:7484 +xref: VSAO:0000306 is_a: UBERON:0000075 ! subdivision of skeletal system relationship: BFO:0000051 UBERON:0000982 ! has part skeletal joint relationship: BFO:0000051 UBERON:0002091 ! has part appendicular skeleton @@ -42748,12 +65912,18 @@ relationship: BFO:0000051 UBERON:0002091 ! has part appendicular skeleton [Term] id: UBERON:0011270 name: dorsal trunk +def: "The part of the trunk that is in the dorsum[cjm]." [UBERONREF:0000006, Wikipedia:Human_back] +xref: EMAPA:35162 +xref: FMA:25056 +xref: MA:0000020 +xref: Wikipedia:Human_back is_a: UBERON:0009569 ! subdivision of trunk relationship: BFO:0000050 UBERON:0001137 ! part of dorsum [Term] id: UBERON:0011272 name: embryonic skin basal layer +xref: EHDAA2:0001845 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0010371 ! ecto-epithelium relationship: BFO:0000050 UBERON:0002199 ! part of integument @@ -42762,6 +65932,9 @@ relationship: RO:0002202 UBERON:0000076 ! external ectoderm [Term] id: UBERON:0011362 name: cranial blood vasculature +def: "A blood vasculature that is part of a head." [OBOL:automatic] +xref: TAO:0005297 +xref: ZFA:0005297 is_a: UBERON:0002200 ! vasculature of head is_a: UBERON:0004537 ! blood vasculature intersection_of: UBERON:0004537 ! blood vasculature @@ -42770,12 +65943,18 @@ intersection_of: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0011565 name: lumen of gastrointestinal system +xref: FMA:54364 +xref: SCTID:432899004 is_a: UBERON:0002553 ! anatomical cavity relationship: BFO:0000050 UBERON:0001007 ! part of digestive system [Term] id: UBERON:0011566 name: lumen of esophagus +def: "An anatomical cavity that is part of a esophagus." [OBOL:automatic] +xref: EMAPA:18380 +xref: FMA:9398 +xref: SCTID:322648002 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0001043 ! esophagus @@ -42786,6 +65965,8 @@ relationship: RO:0002572 UBERON:0001043 ! esophagus [Term] id: UBERON:0011582 name: paired limb/fin skeleton +def: "The collection of all skeletal elements in an individual limb or fin." [https://orcid.org/0000-0002-6601-2165] +xref: VSAO:0000301 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton @@ -42798,11 +65979,26 @@ relationship: RO:0002576 UBERON:0004708 ! paired limb/fin [Term] id: UBERON:0011585 name: cell condensation +def: "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995)." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, PSPUB:0000170, VSAO:0000006] +xref: VSAO:0000006 +xref: XAO:0004021 is_a: UBERON:0000061 ! anatomical structure +[Term] +id: UBERON:0011592 +name: future upper lip +xref: EHDAA2:0002120 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0003235 ! epithelium of upper jaw +relationship: RO:0002202 UBERON:0004068 ! medial nasal prominence +relationship: RO:0002202 UBERON:0005868 ! maxillary prominence + [Term] id: UBERON:0011595 name: jaw region +def: "A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:32905 +xref: NCIT:C114916 is_a: UBERON:0000475 ! organism subdivision is_a: UBERON:0010314 ! structure with developmental contribution from neural crest intersection_of: UBERON:0000475 ! organism subdivision @@ -42814,13 +66010,25 @@ relationship: RO:0002551 UBERON:0001708 ! jaw skeleton [Term] id: UBERON:0011596 name: future lower lip +xref: EHDAA2:0001020 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003236 ! epithelium of lower jaw relationship: RO:0002202 UBERON:0005867 ! mandibular prominence +[Term] +id: UBERON:0011597 +name: bone of upper jaw +def: "Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species)." [https://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0012360 ! bone of jaw +intersection_of: UBERON:0001474 ! bone element +intersection_of: BFO:0000050 UBERON:0001709 ! part of upper jaw region +relationship: BFO:0000050 UBERON:0003277 ! part of skeleton of upper jaw + [Term] id: UBERON:0011642 name: oral epithelium from ectoderm +def: "An epithelium that develops_from a ectoderm and is part of a oral epithelium." [OBOL:automatic] +xref: EHDAA2:0004137 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0002424 ! oral epithelium is_a: UBERON:0010371 ! ecto-epithelium @@ -42833,18 +66041,39 @@ relationship: RO:0002202 UBERON:0009479 ! ectoderm of buccopharyngeal membrane [Term] id: UBERON:0011648 name: jaw muscle +xref: AAO:0000247 +xref: EFO:0003511 +xref: TAO:0000236 +xref: XAO:0003269 +xref: ZFA:0000236 is_a: UBERON:0002376 ! cranial muscle relationship: RO:0002216 GO:0071626 ! capable of part of mastication [Term] id: UBERON:0011676 name: subdivision of organism along main body axis +def: "A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0013701 ! part of main body axis +[Term] +id: UBERON:0011677 +name: trunk vertebra +def: "A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly." [UBERONREF:0000006] +is_a: UBERON:0003463 ! trunk bone +is_a: UBERON:0004247 ! bone of dorsum +is_a: UBERON:0004451 ! trunk or cervical vertebra +intersection_of: UBERON:0002412 ! vertebra +intersection_of: BFO:0000050 UBERON:0009568 ! part of trunk region of vertebral column +relationship: BFO:0000050 UBERON:0009568 ! part of trunk region of vertebral column + [Term] id: UBERON:0011695 name: embryonic cardiovascular system +def: "A cardiovascular system that is part of a conceptus." [OBOL:automatic] +xref: EHDAA2:0000216 +xref: FMA:305965 +xref: NCIT:C34148 is_a: UBERON:0004535 ! cardiovascular system intersection_of: UBERON:0004535 ! cardiovascular system intersection_of: BFO:0000050 UBERON:0004716 ! part of conceptus @@ -42853,15 +66082,30 @@ relationship: BFO:0000050 UBERON:0004716 ! part of conceptus [Term] id: UBERON:0011772 name: lower jaw opening +def: "An anatomical space that is part of a bone of lower jaw." [OBOL:automatic] +xref: AAO:0000273 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0004768 ! bone of lower jaw relationship: BFO:0000050 UBERON:0004768 ! part of bone of lower jaw relationship: RO:0002572 UBERON:0004768 ! bone of lower jaw +[Term] +id: UBERON:0011773 +name: upper jaw opening +def: "An anatomical space that is part of a bone of upper jaw." [OBOL:automatic] +xref: AAO:0000621 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0011597 ! bone of upper jaw +relationship: BFO:0000050 UBERON:0011597 ! part of bone of upper jaw +relationship: RO:0002572 UBERON:0011597 ! bone of upper jaw + [Term] id: UBERON:0011777 name: nucleus of spinal cord +def: "A neural nucleus that is part of the spinal cord." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:77011 is_a: UBERON:0000125 ! neural nucleus intersection_of: UBERON:0000125 ! neural nucleus intersection_of: BFO:0000050 UBERON:0002240 ! part of spinal cord @@ -42870,6 +66114,7 @@ relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord [Term] id: UBERON:0011779 name: nerve of head region +def: "A nerve that is part of a head." [OBOL:automatic] is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -42878,11 +66123,15 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:0011814 name: non-neurogenic ectodermal placode +def: "Ectodermal placode that does not develop into a component of the nervous system." [http://orcid.org/0000-0002-6601-2165, PMID:11523831] is_a: UBERON:0005085 ! ectodermal placode [Term] id: UBERON:0011820 name: atrioventricular region +def: "An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0004149 +xref: FMA:85125 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction @@ -42892,16 +66141,21 @@ intersection_of: RO:0002176 UBERON:0002082 ! cardiac ventricle relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002176 UBERON:0002081 ! cardiac atrium relationship: RO:0002176 UBERON:0002082 ! cardiac ventricle -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0011821 name: irregular connective tissue +def: "Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium." [FMA:20107] +xref: FMA:20107 is_a: UBERON:0002384 ! connective tissue [Term] id: UBERON:0011822 name: dense irregular connective tissue +def: "Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium." [FMA:20109, Wikipedia:Dense_irregular_connective_tissue] +xref: FMA:20109 +xref: NCIT:C32882 +xref: Wikipedia:Dense_irregular_connective_tissue is_a: UBERON:0011821 ! irregular connective tissue is_a: UBERON:0011823 ! dense connective tissue intersection_of: UBERON:0011821 ! irregular connective tissue @@ -42912,6 +66166,10 @@ relationship: BFO:0000051 GO:0071953 ! has part elastic fiber [Term] id: UBERON:0011823 name: dense connective tissue +def: "Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets." [Wikipedia:Dense_connective_tissue] +xref: AAO:0000121 +xref: NCIT:C32450 +xref: Wikipedia:Dense_connective_tissue is_a: UBERON:0002384 ! connective tissue intersection_of: UBERON:0002384 ! connective tissue intersection_of: RO:0002473 UBERON:0011860 ! collection of collagen fibrils @@ -42921,16 +66179,23 @@ relationship: RO:0002473 UBERON:0011860 ! collection of collagen fibrils [Term] id: UBERON:0011824 name: fibrous connective tissue +xref: FMA:75634 +xref: SCTID:363130003 is_a: UBERON:0011822 ! dense irregular connective tissue [Term] id: UBERON:0011825 name: loose connective tissue +def: "Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue." [FMA:19783] +xref: FMA:19783 +xref: NCIT:C33007 +xref: Wikipedia:Loose_connective_tissue is_a: UBERON:0011821 ! irregular connective tissue [Term] id: UBERON:0011858 name: acinus of exocrine gland +def: "An acinus that is part of a exocrine gland." [OBOL:automatic] is_a: UBERON:0009842 ! glandular acinus intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0002365 ! part of exocrine gland @@ -42939,6 +66204,10 @@ relationship: BFO:0000050 UBERON:0002365 ! part of exocrine gland [Term] id: UBERON:0011860 name: collection of collagen fibrils +xref: FMA:63212 +xref: MESH:D024022 +xref: NCIT:C32339 +xref: NIF_Subcellular:sao7547390221 is_a: UBERON:0000476 ! acellular anatomical structure relationship: RO:0002473 GO:0005581 ! collagen trimer relationship: RO:0002473 GO:0098643 ! banded collagen fibril @@ -42946,6 +66215,7 @@ relationship: RO:0002473 GO:0098643 ! banded collagen fibril [Term] id: UBERON:0011861 name: aorta collagen fibril +def: "The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011640] is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils @@ -42956,6 +66226,7 @@ relationship: RO:0002433 UBERON:0004664 ! aorta tunica adventitia [Term] id: UBERON:0011862 name: pulmonary collagen fibril +def: "The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011641] is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils @@ -42966,6 +66237,7 @@ relationship: RO:0002433 UBERON:0002048 ! lung [Term] id: UBERON:0011863 name: bone collagen fibril +def: "The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011642] is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element @@ -42974,6 +66246,7 @@ relationship: BFO:0000050 UBERON:0001474 ! part of bone element [Term] id: UBERON:0011864 name: tendon collagen fibril +def: "The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011643] is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils intersection_of: BFO:0000050 UBERON:0000043 ! part of tendon @@ -42983,6 +66256,7 @@ relationship: RO:0002433 UBERON:0000043 ! tendon [Term] id: UBERON:0011865 name: corneal stroma collagen fibril +def: "The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity." [MP:0011650] is_a: UBERON:0010313 ! neural crest-derived structure is_a: UBERON:0011860 ! collection of collagen fibrils intersection_of: UBERON:0011860 ! collection of collagen fibrils @@ -42990,9 +66264,22 @@ intersection_of: BFO:0000050 UBERON:0001777 ! part of substantia propria of corn relationship: BFO:0000050 UBERON:0001777 ! part of substantia propria of cornea relationship: RO:0002433 UBERON:0001777 ! substantia propria of cornea +[Term] +id: UBERON:0011878 +name: muscle layer of esophagus +def: "A muscle layer that is part of a wall of esophagus." [OBOL:automatic] +xref: FMA:62998 +is_a: UBERON:0018261 ! muscular coat of digestive tract +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus +relationship: BFO:0000050 UBERON:0001096 ! part of wall of esophagus +relationship: BFO:0000051 UBERON:0001134 ! has part skeletal muscle tissue + [Term] id: UBERON:0011892 name: anterior uvea +def: "Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris." [MP:0005194] +xref: SCTID:280656002 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure relationship: BFO:0000050 UBERON:0001768 ! part of uvea @@ -43004,6 +66291,10 @@ relationship: RO:0002433 UBERON:0001801 ! anterior segment of eyeball [Term] id: UBERON:0011899 name: epimysium +def: "Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous." [Wikipedia:Epimysium] +xref: FMA:9726 +xref: NCIT:C32527 +xref: Wikipedia:Epimysium is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0011822 ! dense irregular connective tissue relationship: BFO:0000050 UBERON:0001134 ! part of skeletal muscle tissue @@ -43013,6 +66304,9 @@ relationship: RO:0002150 UBERON:0000043 ! tendon [Term] id: UBERON:0011919 name: yolk sac blood island +def: "Masses of developing blood cells attached to endothelium in the yolk sac." [MP:0011204] +xref: EHDAA2:0000177 +xref: EMAPA:16115 is_a: UBERON:0000478 ! extraembryonic structure is_a: UBERON:0003061 ! blood island intersection_of: UBERON:0003061 ! blood island @@ -43023,34 +66317,94 @@ relationship: RO:0002202 UBERON:0003316 ! mesenchyme of yolk sac [Term] id: UBERON:0011953 name: stomach glandular region +def: "A region of the stomach that is lined with glandular epithelium." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:17623 +xref: MA:0001613 +xref: NCIT:C77661 +xref: SCTID:27633001 is_a: UBERON:0009870 ! zone of stomach intersection_of: UBERON:0009870 ! zone of stomach intersection_of: BFO:0000051 UBERON:0006924 ! has part stomach glandular epithelium relationship: BFO:0000051 UBERON:0006924 ! has part stomach glandular epithelium +[Term] +id: UBERON:0011955 +name: left hepatic vein +def: "A hepatic vein that is part of a left lobe of liver." [OBOL:automatic] +xref: FMA:14339 +xref: MA:0003032 +xref: SCTID:55188000 +is_a: UBERON:0001143 ! hepatic vein +intersection_of: UBERON:0001143 ! hepatic vein +intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: BFO:0000050 UBERON:0001115 ! part of left lobe of liver + +[Term] +id: UBERON:0011956 +name: right hepatic vein +def: "A hepatic vein that is part of a right lobe of liver." [OBOL:automatic] +xref: FMA:14338 +xref: MA:0003034 +xref: SCTID:18135006 +is_a: UBERON:0001143 ! hepatic vein +intersection_of: UBERON:0001143 ! hepatic vein +intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: BFO:0000050 UBERON:0001114 ! part of right lobe of liver + [Term] id: UBERON:0011997 name: coelom +def: "The aggregate of the coelemic cavity lumen plus the membranes that line the lumen." [UBERON:cjm, Wikipedia:Body_cavity, Wikipedia:Coelom] +xref: EHDAA2:0004731 +xref: Wikipedia:Coelom is_a: UBERON:0000481 ! multi-tissue structure relationship: RO:0002160 NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0012054 name: myocoele +def: "The cavity within a myotome." [http://medical-dictionary.thefreedictionary.com/myocoele] +xref: EMAPA:31134 +xref: VHOG:0001283 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0003082 ! myotome relationship: RO:0002572 UBERON:0003082 ! myotome +[Term] +id: UBERON:0012071 +name: palate bone +def: "Any bone that is part of a palate." [https://orcid.org/0000-0002-6601-2165] +xref: NCIT:C33248 +is_a: UBERON:0003457 ! head bone +is_a: UBERON:0008907 ! dermal bone +intersection_of: UBERON:0001474 ! bone element +intersection_of: BFO:0000050 UBERON:0007375 ! part of roof of mouth +relationship: BFO:0000050 UBERON:0012072 ! part of palatal part of dermatocranium + +[Term] +id: UBERON:0012072 +name: palatal part of dermatocranium +is_a: UBERON:0000075 ! subdivision of skeletal system +relationship: BFO:0000050 UBERON:0003113 ! part of dermatocranium +relationship: BFO:0000050 UBERON:0007375 ! part of roof of mouth + [Term] id: UBERON:0012075 name: replacement bone +def: "Bone that forms as a replacement of another structural tissue." [ZFA:0001628] +xref: AAO:0010768 +xref: TAO:0001637 +xref: ZFA:0001628 is_a: UBERON:0001474 ! bone element is_a: UBERON:0010522 ! replacement element [Term] id: UBERON:0012082 name: bronchial lumen +def: "An anatomical cavity that is part of a bronchus." [OBOL:automatic] +xref: FMA:62646 +xref: SCTID:199401001 is_a: UBERON:0000464 ! anatomical space relationship: BFO:0000050 UBERON:0002185 ! part of bronchus relationship: RO:0002572 UBERON:0002185 ! bronchus @@ -43058,6 +66412,9 @@ relationship: RO:0002572 UBERON:0002185 ! bronchus [Term] id: UBERON:0012172 name: stomach primordium +def: "A primordium that has the potential to develop into a stomach." [OBOL:automatic] +xref: EFO:0002580 +xref: NCIT:C34305 is_a: UBERON:0001048 ! primordium intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0000945 ! stomach @@ -43067,6 +66424,9 @@ relationship: RO:0002387 UBERON:0000945 ! stomach [Term] id: UBERON:0012180 name: head or neck skin +def: "A zone of skin that is part of a craniocervical region." [OBOL:automatic] +xref: MA:0000574 +xref: NCIT:C12294 is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0007811 ! part of craniocervical region @@ -43075,6 +66435,9 @@ relationship: BFO:0000050 UBERON:0007811 ! part of craniocervical region [Term] id: UBERON:0012193 name: phrenic vein +def: "The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins." [ncithesaurus:Phrenic_Vein] +xref: MA:0002194 +xref: NCIT:C53062 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0001103 ! diaphragm @@ -43083,6 +66446,8 @@ relationship: RO:0002179 UBERON:0001103 ! diaphragm [Term] id: UBERON:0012254 name: abdominal aorta artery +def: "An artery that originates from the abdominal aorta." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Abdominal_aorta#Branches] +xref: SCTID:281470000 is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002380 UBERON:0001516 ! abdominal aorta @@ -43091,12 +66456,16 @@ relationship: RO:0002380 UBERON:0001516 ! abdominal aorta [Term] id: UBERON:0012274 name: columnar epithelium +def: "An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]." [Wikipedia:Columnar_epithelium] +xref: Wikipedia:Columnar_epithelium is_a: UBERON:0000483 ! epithelium relationship: BFO:0000051 CL:0000075 ! has part columnar/cuboidal epithelial cell [Term] id: UBERON:0012275 name: meso-epithelium +def: "Epithelium that derives from the mesoderm. [Automatically generated definition]." [OBOL:automatic] +xref: FMA:86452 is_a: UBERON:0000483 ! epithelium is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000483 ! epithelium @@ -43105,6 +66474,9 @@ intersection_of: RO:0002202 UBERON:0000926 ! mesoderm [Term] id: UBERON:0012314 name: embryonic facial prominence +def: "One of five swellings formed during the development of the face." [http://www.indiana.edu/~anat550/hnanim/face/face.html] +xref: FMA:293103 +xref: SCTID:89066004 is_a: UBERON:0002050 ! embryonic structure relationship: BFO:0000050 UBERON:0000033 ! part of head relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata @@ -43112,6 +66484,8 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata [Term] id: UBERON:0012320 name: cervical artery +def: "An artery of the neck." [https://orcid.org/0000-0002-6601-2165] +xref: NCIT:C52850 is_a: UBERON:0001637 ! artery is_a: UBERON:0003502 ! neck blood vessel intersection_of: UBERON:0001637 ! artery @@ -43120,31 +66494,65 @@ intersection_of: BFO:0000050 UBERON:0000974 ! part of neck [Term] id: UBERON:0012321 name: deep cervical artery +def: "The deep cervical artery (Profunda cervicalis) is an artery of the neck." [Wikipedia:Deep_cervical_artery] +xref: FMA:10659 +xref: SCTID:244223002 +xref: Wikipedia:Deep_cervical_artery is_a: UBERON:0012320 ! cervical artery intersection_of: UBERON:0012320 ! cervical artery intersection_of: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: BFO:0000050 UBERON:0035551 ! part of deep vasculature relationship: RO:0002252 UBERON:0004688 ! costo-cervical trunk -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012324 name: transverse cervical artery +def: "The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery." [Wikipedia:Transverse_cervical_artery] +xref: FMA:10664 +xref: MA:0001936 +xref: SCTID:244224008 +xref: Wikipedia:Transverse_cervical_artery is_a: UBERON:0012320 ! cervical artery -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012360 name: bone of jaw +def: "A bone element that is part of a jaw region." [OBOL:automatic] +xref: EMAPA:35453 +xref: MA:0003130 +xref: SCTID:369003004 is_a: UBERON:0003462 ! facial bone is_a: UBERON:0013765 ! digestive system element intersection_of: UBERON:0001474 ! bone element intersection_of: BFO:0000050 UBERON:0011595 ! part of jaw region relationship: BFO:0000050 UBERON:0001708 ! part of jaw skeleton +[Term] +id: UBERON:0012361 +name: internal anal region +xref: EHDAA2:0004588 +is_a: UBERON:0000481 ! multi-tissue structure +relationship: BFO:0000050 UBERON:0001353 ! part of anal region + +[Term] +id: UBERON:0012367 +name: muscle layer of intestine +def: "A muscle layer that is part of an intestine." [OBOL:automatic] +xref: FMA:15697 +is_a: UBERON:0018261 ! muscular coat of digestive tract +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +relationship: BFO:0000050 UBERON:0001262 ! part of wall of intestine + [Term] id: UBERON:0012375 name: subserosa +def: "A layer of tissue between the muscularis and serosa." [Wikipedia:Subserosa] +comment: Contains nerves, blood vessels, lymphatics and lymph nodes +xref: FMA:45636 +xref: NCIT:C94494 +xref: SCTID:2255006 +xref: Wikipedia:Subserosa is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002220 UBERON:0000042 ! adjacent to serous membrane @@ -43152,30 +66560,54 @@ intersection_of: RO:0002473 UBERON:0006815 ! areolar connective tissue relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002220 UBERON:0000042 ! adjacent to serous membrane relationship: RO:0002473 UBERON:0006815 ! areolar connective tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012416 name: respiratory system arterial smooth muscle +xref: MA:0001802 is_a: UBERON:0004297 ! respiratory system blood vessel smooth muscle is_a: UBERON:0004695 ! arterial system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003643 ! part of respiratory system arterial blood vessel relationship: BFO:0000050 UBERON:0003643 ! part of respiratory system arterial blood vessel -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0012418 name: respiratory system venous smooth muscle +def: "A smooth muscle tissue that is part of a respiratory system venous blood vessel." [OBOL:automatic] +xref: MA:0001812 is_a: UBERON:0004696 ! venous system smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0003476 ! part of respiratory system venous blood vessel relationship: BFO:0000050 UBERON:0003476 ! part of respiratory system venous blood vessel -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0012423 +name: layer of microvilli +def: "A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]." [GO:0005902, Wikipedia:Microvillus] +xref: FMA:67296 +xref: MESH:D008871 +xref: NCIT:C33112 +xref: Wikipedia:Microvillus +is_a: UBERON:0005162 ! multi cell part structure +relationship: RO:0002473 GO:0005902 ! microvillus + +[Term] +id: UBERON:0012425 +name: striated border microvillus layer +def: "A microvillus layer that is striated and found in the intestine." [http://medical-dictionary.thefreedictionary.com/striated+border, http://orcid.org/0000-0002-6601-2165] +xref: FMA:70978 +xref: NCIT:C33634 +is_a: UBERON:0012423 ! layer of microvilli +relationship: BFO:0000050 UBERON:0000160 ! part of intestine [Term] id: UBERON:0012429 name: hematopoietic tissue +def: "Blood-forming tissue, consisting of reticular fibers and cells." [http://encyclopedia2.thefreedictionary.com/hematopoietic+tissue] +xref: CALOHA:TS-2142 +xref: FMA:14073 +xref: NCIT:C13051 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0034769 ! lymphomyeloid tissue intersection_of: UBERON:0000479 ! tissue @@ -43186,6 +66618,10 @@ relationship: site_of GO:0030097 ! hemopoiesis [Term] id: UBERON:0012430 name: tunica fibrosa of eyeball +def: "The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth." [Wikipedia:Fibrous_tunic_of_eyeball] +xref: FMA:58102 +xref: SCTID:361318005 +xref: Wikipedia:Fibrous_tunic_of_eyeball is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0004923 ! organ component layer is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -43193,9 +66629,44 @@ relationship: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye relationship: BFO:0000051 UBERON:0000964 ! has part cornea relationship: BFO:0000051 UBERON:0001773 ! has part sclera +[Term] +id: UBERON:0012463 +name: cloacal lumen +def: "An anatomical space that is enclosed by a cloaca." [OBOL:automatic] +xref: TAO:0000330 +xref: ZFA:0000330 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0000162 ! cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0012465 ! part of lumen of terminal part of digestive tract +relationship: RO:0002572 UBERON:0000162 ! cloaca + +[Term] +id: UBERON:0012464 +name: cloacal vent +def: "The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0000161 ! orifice +intersection_of: UBERON:0000161 ! orifice +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012465 +name: lumen of terminal part of digestive tract +def: "An anatomical space that is enclosed by a terminal part of digestive tract." [OBOL:automatic] +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0006866 ! terminal part of digestive tract +relationship: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract +relationship: RO:0002572 UBERON:0006866 ! terminal part of digestive tract + [Term] id: UBERON:0012466 name: extraembryonic cavity +xref: EHDAA2:0000472 +xref: EMAPA:16054 +xref: VHOG:0000767 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic component @@ -43204,14 +66675,25 @@ relationship: BFO:0000050 UBERON:0016887 ! part of entire extraembryonic compone [Term] id: UBERON:0012467 name: enclosed anatomical space +def: "An anatomical space with no opening to another space or to the exterior." [AEO:0000222] +xref: AEO:0000222 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0000086 PATO:0000608 relationship: RO:0000086 PATO:0000608 +[Term] +id: UBERON:0012469 +name: external anal region +xref: EHDAA2:0004589 +is_a: UBERON:0000481 ! multi-tissue structure +relationship: BFO:0000050 UBERON:0001353 ! part of anal region + [Term] id: UBERON:0012475 name: skeleton of pectoral complex +def: "The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle." [https://orcid.org/0000-0002-6601-2165] +xref: FMA:24139 is_a: UBERON:0010912 ! subdivision of skeleton intersection_of: UBERON:0010912 ! subdivision of skeleton intersection_of: RO:0002576 UBERON:0010708 ! pectoral complex @@ -43219,17 +66701,161 @@ relationship: BFO:0000050 UBERON:0002091 ! part of appendicular skeleton relationship: BFO:0000050 UBERON:0010708 ! part of pectoral complex relationship: RO:0002576 UBERON:0010708 ! pectoral complex +[Term] +id: UBERON:0012477 +name: dorsal part of neck +def: "The posterior region of the neck, including the suboccipital region." [MP:0012723] +xref: BTO:0000957 +xref: FMA:24189 +xref: SCTID:182326009 +xref: SCTID:304036007 +is_a: UBERON:0005434 ! cervical region +relationship: BFO:0000050 UBERON:0001137 ! part of dorsum +relationship: BSPO:0015101 UBERON:0000974 ! neck + +[Term] +id: UBERON:0012478 +name: cloacal gland +def: "A gland that is part of a cloaca." [OBOL:automatic] +is_a: UBERON:0003408 ! gland of digestive tract +intersection_of: UBERON:0002530 ! gland +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012480 +name: cloacal mucosa +def: "A mucosa that is part of a cloaca [Automatically generated definition]." [OBOL:automatic] +is_a: UBERON:0000344 ! mucosa +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012481 +name: cloacal epithelium +def: "An epithelium that is part of a cloaca." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:27577 +xref: EMAPA:36070 +xref: ZFA:0005783 +is_a: UBERON:0003929 ! digestive tract epithelium +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012482 +name: submucosa of cloaca +def: "A submucosa that is part of a cloaca [Automatically generated definition]." [OBOL:automatic] +is_a: UBERON:0018257 ! submucosa of digestive tract +intersection_of: UBERON:0000009 ! submucosa +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012483 +name: serosa of cloaca +def: "A serous membrane that is part of a cloaca [Automatically generated definition]." [OBOL:automatic] +is_a: UBERON:0000042 ! serous membrane +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012485 +name: cloacal villus +is_a: UBERON:0012423 ! layer of microvilli +intersection_of: UBERON:0012423 ! layer of microvilli +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012486 +name: muscle layer of cloaca +def: "A muscular coat that is part of a cloaca." [OBOL:automatic] +is_a: UBERON:0018261 ! muscular coat of digestive tract +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0012488 +name: muscle layer of duodenum +def: "A muscular coat that is part of a duodenum." [OBOL:automatic] +xref: FMA:14944 +xref: SCTID:362147007 +is_a: UBERON:0011201 ! muscle layer of small intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + +[Term] +id: UBERON:0012489 +name: muscle layer of colon +def: "A muscular coat that is part of a colon." [OBOL:automatic] +xref: EMAPA:27383 +xref: FMA:14986 +xref: MA:0003198 +xref: SCTID:362158003 +is_a: UBERON:0011198 ! muscle layer of large intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0012490 +name: muscle layer of anal canal +def: "A muscular coat that is part of a anal canal." [OBOL:automatic] +xref: FMA:15708 +xref: SCTID:362171000 +is_a: UBERON:0004121 ! ectoderm-derived structure +is_a: UBERON:0011198 ! muscle layer of large intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal + [Term] id: UBERON:0012504 name: adventitia of esophagus +def: "An adventitia that is part of a esophagus." [OBOL:automatic] +xref: FMA:63006 +xref: SCTID:85950006 is_a: UBERON:0005742 ! adventitia intersection_of: UBERON:0005742 ! adventitia intersection_of: BFO:0000050 UBERON:0001043 ! part of esophagus relationship: BFO:0000050 UBERON:0001043 ! part of esophagus +[Term] +id: UBERON:0012650 +name: gastroduodenal junction +def: "An anatomical junction that connects a stomach and connects a duodenum." [OBOL:automatic] +xref: FMA:17046 +xref: SCTID:264014000 +is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0000945 ! stomach +intersection_of: RO:0002176 UBERON:0002114 ! duodenum +relationship: BFO:0000050 UBERON:0000945 ! part of stomach +relationship: RO:0002176 UBERON:0000945 ! stomach +relationship: RO:0002176 UBERON:0002114 ! duodenum + +[Term] +id: UBERON:0012651 +name: mucosa of gastroduodenal junction +def: "A mucosa that is part of a gastroduodenal junction." [OBOL:automatic] +xref: BTO:0005415 +is_a: UBERON:0001199 ! mucosa of stomach +intersection_of: UBERON:0000344 ! mucosa +intersection_of: BFO:0000050 UBERON:0012650 ! part of gastroduodenal junction +relationship: BFO:0000050 UBERON:0001199 ! part of mucosa of stomach +relationship: BFO:0000050 UBERON:0012650 ! part of gastroduodenal junction + [Term] id: UBERON:0013126 name: vein of abdomen +def: "A vein that is part of a abdomen." [OBOL:automatic] +xref: SCTID:281473003 is_a: UBERON:0001638 ! vein is_a: UBERON:0003497 ! abdomen blood vessel intersection_of: UBERON:0001638 ! vein @@ -43238,6 +66864,8 @@ intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen [Term] id: UBERON:0013127 name: pulmonary venous system +def: "The part of the venous system that drains the lungs[Kardong]." [ISBN:0073040584, Wikipedia:Pulmonary_venous_system] +xref: Wikipedia:Pulmonary_venous_system is_a: UBERON:0002049 ! vasculature relationship: BFO:0000050 UBERON:0004582 ! part of venous system relationship: channels_from UBERON:0000102 ! lung vasculature @@ -43245,6 +66873,8 @@ relationship: channels_from UBERON:0000102 ! lung vasculature [Term] id: UBERON:0013136 name: vein of lip +def: "A vein that drains a lip." [OBOL:automatic] +xref: SCTID:367664002 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0001833 ! lip @@ -43254,14 +66884,40 @@ relationship: RO:0002376 UBERON:0001653 ! facial vein [Term] id: UBERON:0013140 name: systemic vein +def: "Any vein within the general circulation that transports blood back to the right atrium of the heart." [ncithesaurus:Systemic_Vein] +xref: FMA:66644 +xref: NCIT:C33719 +xref: SCTID:244389004 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0004581 ! part of systemic venous system relationship: BFO:0000050 UBERON:0004581 ! part of systemic venous system +[Term] +id: UBERON:0013158 +name: foregut-midgut junction gland +def: "A gland that is part of a foregut-midgut junction." [OBOL:automatic] +xref: EHDAA2:0000574 +xref: EMAPA:17065 +is_a: UBERON:0003408 ! gland of digestive tract +intersection_of: UBERON:0002530 ! gland +intersection_of: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction +relationship: BFO:0000050 UBERON:0006235 ! part of foregut-midgut junction + +[Term] +id: UBERON:0013212 +name: anal sac gland secretion +def: "A bodily secretion that is produced by a gland of anal sac." [OBOL:automatic] +is_a: UBERON:0000456 ! secretion of exocrine gland +intersection_of: UBERON:0000456 ! secretion of exocrine gland +intersection_of: RO:0003001 UBERON:0004760 ! produced by gland of anal canal +relationship: RO:0003001 UBERON:0004760 ! produced by gland of anal canal + [Term] id: UBERON:0013232 name: serous acinus +def: "The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] +xref: FMA:86279 is_a: UBERON:0011858 ! acinus of exocrine gland intersection_of: UBERON:0009842 ! glandular acinus intersection_of: BFO:0000050 UBERON:0000409 ! part of serous gland @@ -43271,6 +66927,13 @@ relationship: RO:0002473 CL:0000313 ! serous secreting cell [Term] id: UBERON:0013411 name: cranial cavity +def: "Anatomical cavity that is the lumen of the skull and contains the brain." [UBERON:cjm] +xref: FMA:9644 +xref: MA:0003061 +xref: NCIT:C77638 +xref: neuronames:2806 +xref: SCTID:264452006 +xref: Wikipedia:Cranial_cavity is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0003129 ! skull @@ -43280,15 +66943,99 @@ relationship: RO:0002572 UBERON:0003129 ! skull [Term] id: UBERON:0013479 name: lung endothelium +def: "A blood vessel endothelium that is part of a lung [Automatically generated definition]." [OBOL:automatic] +xref: BTO:0004128 +xref: CALOHA:TS-0573 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0004702 ! respiratory system blood vessel endothelium intersection_of: UBERON:0004638 ! blood vessel endothelium intersection_of: BFO:0000050 UBERON:0002048 ! part of lung +[Term] +id: UBERON:0013501 +name: cloacal sphincter +def: "A sphincter muscle that is part of a cloaca." [OBOL:automatic] +comment: the muscles of the cloacal sphincter specialise into the perineal muscles in mammals (Gegenbaur, 1883; Popowsky, 1899; Nishi, 1938). +xref: NCIT:C34129 +is_a: UBERON:0004590 ! sphincter muscle +is_a: UBERON:0014783 ! cloacal muscle +intersection_of: UBERON:0004590 ! sphincter muscle +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca + +[Term] +id: UBERON:0013503 +name: caudal vertebra cartilage element +def: "A caudal vertebra endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] +xref: EHDAA2:0000260 +xref: EMAPA:18044 +is_a: UBERON:0011094 ! vertebra cartilage element +is_a: UBERON:0018142 ! caudal vertebra endochondral element +is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue +relationship: RO:0002202 UBERON:0013504 ! caudal vertebra pre-cartilage condensation +relationship: RO:0002387 UBERON:0001095 ! caudal vertebra + +[Term] +id: UBERON:0013504 +name: caudal vertebra pre-cartilage condensation +def: "A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] +xref: EMAPA:18045 +is_a: UBERON:0011095 ! vertebra pre-cartilage condensation +is_a: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: UBERON:0018142 ! caudal vertebra endochondral element +intersection_of: RO:0002473 UBERON:0005866 ! pre-cartilage condensation + +[Term] +id: UBERON:0013505 +name: cervical vertebra cartilage element +def: "A cervical vertebra endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] +xref: EHDAA2:0000240 +is_a: UBERON:0003601 ! neck cartilage +is_a: UBERON:0011094 ! vertebra cartilage element +is_a: UBERON:0015007 ! cervical vertebra endochondral element +is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue +relationship: RO:0002202 UBERON:0013506 ! cervical vertebra pre-cartilage condensation +relationship: RO:0002387 UBERON:0002413 ! cervical vertebra + +[Term] +id: UBERON:0013506 +name: cervical vertebra pre-cartilage condensation +def: "A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] +is_a: UBERON:0011095 ! vertebra pre-cartilage condensation +is_a: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: UBERON:0015007 ! cervical vertebra endochondral element +intersection_of: RO:0002473 UBERON:0005866 ! pre-cartilage condensation + +[Term] +id: UBERON:0013507 +name: thoracic vertebra cartilage element +def: "A thoracic vertebra endochondral element that is composed primarily of cartilage tissue." [OBOL:automatic] +xref: EHDAA2:0002014 +is_a: UBERON:0011094 ! vertebra cartilage element +is_a: UBERON:0015008 ! thoracic vertebra endochondral element +is_a: UBERON:2001457 ! postcranial axial cartilage +intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: RO:0002473 UBERON:0002418 ! cartilage tissue +relationship: RO:0002202 UBERON:0013508 ! thoracic vertebra pre-cartilage condensation +relationship: RO:0002387 UBERON:0002347 ! thoracic vertebra + +[Term] +id: UBERON:0013508 +name: thoracic vertebra pre-cartilage condensation +def: "A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation." [OBOL:automatic] +is_a: UBERON:0011095 ! vertebra pre-cartilage condensation +is_a: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: UBERON:0015008 ! thoracic vertebra endochondral element +intersection_of: RO:0002473 UBERON:0005866 ! pre-cartilage condensation + [Term] id: UBERON:0013514 name: space surrounding organism +def: "The space that surrounds an organism." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002221 UBERON:0000468 ! multicellular organism @@ -43306,15 +67053,33 @@ relationship: subdivision_of UBERON:0000025 ! tube [Term] id: UBERON:0013525 name: stomach lumen +def: "The anatomical space that is enclosed by a stomach." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:18395 +xref: FMA:14585 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0000945 ! stomach relationship: BFO:0000050 UBERON:0011565 ! part of lumen of gastrointestinal system relationship: RO:0002572 UBERON:0000945 ! stomach +[Term] +id: UBERON:0013636 +name: epithelium of intestinal villus +def: "An epithelium that is part of a intestinal villus." [OBOL:automatic] +xref: FMA:63587 +is_a: UBERON:0001902 ! epithelium of small intestine +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus +relationship: BFO:0000050 UBERON:0001213 ! part of intestinal villus +relationship: BFO:0000050 UBERON:0001902 ! part of epithelium of small intestine + [Term] id: UBERON:0013685 name: foramen of skull +def: "Anatomical space that is an opening in a bone of the skull." [http://orcid.org/0000-0002-6601-2165, TAO:curator] +xref: FMA:53165 +xref: SCTID:276742007 +xref: Wikipedia:Foramina_of_the_skull is_a: UBERON:0005744 ! bone foramen intersection_of: UBERON:0005744 ! bone foramen intersection_of: BFO:0000050 UBERON:0003129 ! part of skull @@ -43323,25 +67088,51 @@ relationship: BFO:0000050 UBERON:0003129 ! part of skull [Term] id: UBERON:0013686 name: anatomical conduit space +def: "An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]." [FMA:9338, http://orcid.org/0000-0002-6601-2165] +xref: FMA:9338 is_a: UBERON:0000464 ! anatomical space relationship: RO:0002176 UBERON:0000464 {cardinality="2"} ! anatomical space relationship: RO:0002572 UBERON:0004111 ! anatomical conduit -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0013694 name: brain endothelium +def: "Vascular endothelium found in blood vessels of the blood-brain-barrier." [CALOHA:TS-0092] +xref: BTO:0001852 +xref: BTO:0003248 +xref: CALOHA:TS-0092 is_a: UBERON:0001986 ! endothelium is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0000955 ! part of brain relationship: BFO:0000050 UBERON:0000955 ! part of brain +[Term] +id: UBERON:0013695 +name: colon endothelium +def: "Vascular endothelium found in colon blood vessels." [CALOHA:TS-0162] +xref: CALOHA:TS-0162 +is_a: UBERON:0000397 ! colonic epithelium +is_a: UBERON:0001986 ! endothelium +intersection_of: UBERON:0001986 ! endothelium +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:0013697 +name: exocrine pancreas epithelium +def: "Epithelium lining the exocrine pancreas." [CALOHA:TS-2108] +xref: CALOHA:TS-2108 +is_a: UBERON:0005911 ! endo-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas +relationship: BFO:0000050 UBERON:0000017 ! part of exocrine pancreas + [Term] id: UBERON:0013700 name: axial musculature +def: "Musculature of the head and neck, spine, and ribs." [HP:0003327] +xref: EHDAA2:0000159 +xref: EMAPA:18166 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0013701 ! part of main body axis @@ -43352,18 +67143,26 @@ relationship: RO:0002371 UBERON:0005944 ! axial skeleton plus cranial skeleton [Term] id: UBERON:0013701 name: main body axis +def: "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages." [https://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000475 ! organism subdivision relationship: RO:0002160 NCBITaxon:6072 ! Eumetazoa [Term] id: UBERON:0013702 name: body proper +def: "The region of the organism associated with the visceral organs." [AEO:0000103] +xref: AEO:0000103 +xref: BTO:0001489 +xref: FMA:231424 is_a: UBERON:0000475 ! organism subdivision relationship: BFO:0000050 UBERON:0013701 ! part of main body axis [Term] id: UBERON:0013704 name: notochordal canal +def: "A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily." [http://medical-dictionary.thefreedictionary.com/notochordal+canal] +xref: FMA:293127 +xref: NCIT:C34230 is_a: UBERON:0004111 ! anatomical conduit is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0004111 ! anatomical conduit @@ -43373,6 +67172,8 @@ relationship: BFO:0000050 UBERON:0006268 ! part of notochordal process [Term] id: UBERON:0013727 name: notochordal fluid +def: "Fluid contained within the notochordal canal." [http://animaldiversity.org/accounts/Latimeria_chalumnae/, http://orcid.org/0000-0002-6601-2165] +comment: Distinct feature of coelocanths is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid intersection_of: BFO:0000050 UBERON:0036242 ! part of post-embryonic notochord @@ -43383,6 +67184,8 @@ relationship: RO:0001025 UBERON:0013704 ! notochordal canal [Term] id: UBERON:0013754 name: integumentary system layer +def: "An organ component layer that is part of a integumental system." [OBOL:automatic] +xref: SCTID:314820002 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system @@ -43391,6 +67194,8 @@ relationship: BFO:0000050 UBERON:0002416 ! part of integumental system [Term] id: UBERON:0013755 name: arterial blood +def: "A blood that is part of a artery." [OBOL:automatic] +xref: FMA:83066 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: RO:0001025 UBERON:0001637 ! artery @@ -43399,6 +67204,8 @@ relationship: RO:0001025 UBERON:0001637 ! artery [Term] id: UBERON:0013756 name: venous blood +def: "A blood that is part of a vein." [OBOL:automatic] +xref: FMA:83067 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: RO:0001025 UBERON:0001638 ! vein @@ -43407,6 +67214,9 @@ relationship: RO:0001025 UBERON:0001638 ! vein [Term] id: UBERON:0013757 name: capillary blood +def: "A blood that is part of a capillary." [OBOL:automatic] +xref: FMA:263901 +xref: NCIT:C32212 is_a: UBERON:0000178 ! blood intersection_of: UBERON:0000178 ! blood intersection_of: RO:0001025 UBERON:0001982 ! capillary @@ -43415,6 +67225,8 @@ relationship: RO:0001025 UBERON:0001982 ! capillary [Term] id: UBERON:0013765 name: digestive system element +def: "Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements." [http://orcid.org/0000-0002-6601-2165] +xref: SCTID:272627002 is_a: UBERON:0000062 ! organ intersection_of: UBERON:0000062 ! organ intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system @@ -43423,11 +67235,19 @@ relationship: BFO:0000050 UBERON:0001007 ! part of digestive system [Term] id: UBERON:0013768 name: great vessel of heart +def: "Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart." [Wikipedia:Great_vessels] +comment: Groupings may vary - typically pulmonary vessels and aorta and vena cavae +xref: EMAPA:36460 +xref: SCTID:304066000 +xref: Wikipedia:Great_vessels is_a: UBERON:0001981 ! blood vessel [Term] id: UBERON:0014387 name: mesenchyme derived from neural crest +def: "Mesenchyme that develops_from the neural crest[Automatically generated definition]." [https://github.com/obophenotype/uberon/issues/248, OBOL:automatic] +xref: EMAPA:32735 +xref: FMA:293883 is_a: UBERON:0003104 ! mesenchyme is_a: UBERON:0010313 ! neural crest-derived structure intersection_of: UBERON:0003104 ! mesenchyme @@ -43436,6 +67256,7 @@ intersection_of: RO:0002202 UBERON:0002342 ! neural crest [Term] id: UBERON:0014398 name: respiratory muscle +def: "Muscle that is part of the respiratory system." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0003831 ! respiratory system muscle intersection_of: UBERON:0001630 ! muscle organ intersection_of: RO:0002216 GO:0007585 ! capable of part of respiratory gaseous exchange by respiratory system @@ -43445,15 +67266,30 @@ relationship: RO:0002473 UBERON:0001134 ! skeletal muscle tissue [Term] id: UBERON:0014399 name: sinusoidal space +def: "An anatomical space that is enclosed by a sinusoid." [OBOL:automatic] +xref: FMA:63133 is_a: UBERON:0010161 ! lumen of blood vessel intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0003909 ! sinusoid relationship: BFO:0000050 UBERON:0003909 ! part of sinusoid relationship: RO:0002572 UBERON:0003909 ! sinusoid +[Term] +id: UBERON:0014400 +name: hepatic sinusoidal space +def: "A sinusoidal space that is part of a hepatic sinusoid." [OBOL:automatic] +xref: FMA:262090 +is_a: UBERON:0014399 ! sinusoidal space +intersection_of: UBERON:0014399 ! sinusoidal space +intersection_of: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid +relationship: BFO:0000050 UBERON:0001281 ! part of hepatic sinusoid + [Term] id: UBERON:0014402 name: sex-specific anatomical structure +def: "A part of the body present only in a specific gender." [AEO:0000174, AEO:JB] +xref: AEO:0000174 +xref: WBbt:0005752 is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0002353 GO:0007548 ! output of sex differentiation @@ -43462,6 +67298,8 @@ relationship: RO:0002353 GO:0007548 ! output of sex differentiation [Term] id: UBERON:0014404 name: female anatomical structure +def: "A part of the body present only in females." [AEO:0000176, AEO:JB] +xref: AEO:0000176 is_a: UBERON:0014402 ! sex-specific anatomical structure intersection_of: UBERON:0014402 ! sex-specific anatomical structure intersection_of: BFO:0000050 UBERON:0003100 ! part of female organism @@ -43470,6 +67308,9 @@ relationship: BFO:0000050 UBERON:0003100 ! part of female organism [Term] id: UBERON:0014454 name: visceral abdominal adipose tissue +def: "Subcutaneous adipose tissue that is located in the peritoneal cavity." [CALOHA:paula, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/259, MGI:csmith] +xref: BTO:0004041 +xref: CALOHA:TS-2405 is_a: UBERON:0007808 ! adipose tissue of abdominal region intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen @@ -43481,6 +67322,8 @@ relationship: RO:0002007 UBERON:0002075 ! bounding layer of viscus [Term] id: UBERON:0014455 name: subcutaneous abdominal adipose tissue +def: "Subcutaneous adipose tissue that is located in the abdominal region." [CALOHA:paula, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/259, MGI:csmith] +xref: CALOHA:TS-2406 is_a: UBERON:0002190 ! subcutaneous adipose tissue is_a: UBERON:0007808 ! adipose tissue of abdominal region intersection_of: UBERON:0001013 ! adipose tissue @@ -43490,50 +67333,91 @@ intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis [Term] id: UBERON:0014477 name: thoracic skeleton +def: "Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Rib_cage] +xref: EHDAA2:0002013 +xref: FMA:77169 +xref: Wikipedia:Thoracic_skeleton is_a: UBERON:0010912 ! subdivision of skeleton relationship: BFO:0000050 UBERON:0000915 ! part of thoracic segment of trunk relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014610 name: thoracic spinal cord ventral horn +def: "A ventral horn of spinal cord that is part of a thoracic spinal cord." [OBOL:automatic] +xref: BIRNLEX:1410 +xref: SCTID:367876000 is_a: UBERON:0002257 ! ventral horn of spinal cord intersection_of: UBERON:0002257 ! ventral horn of spinal cord intersection_of: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord relationship: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014613 name: cervical spinal cord gray matter +def: "A gray matter of spinal cord that is part of a cervical spinal cord." [OBOL:automatic] +xref: BIRNLEX:1521 +xref: SCTID:362438009 is_a: UBERON:0002315 ! gray matter of spinal cord intersection_of: UBERON:0002315 ! gray matter of spinal cord intersection_of: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord relationship: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014621 name: cervical spinal cord ventral horn +def: "A ventral horn of spinal cord that is part of a cervical spinal cord." [OBOL:automatic] +xref: BIRNLEX:1680 +xref: SCTID:174363005 is_a: UBERON:0002257 ! ventral horn of spinal cord intersection_of: UBERON:0002257 ! ventral horn of spinal cord intersection_of: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord relationship: BFO:0000050 UBERON:0002726 ! part of cervical spinal cord -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014636 name: thoracic spinal cord gray matter +def: "A gray matter of spinal cord that is part of a thoracic spinal cord." [OBOL:automatic] +xref: BIRNLEX:980 +xref: SCTID:362441000 is_a: UBERON:0002315 ! gray matter of spinal cord intersection_of: UBERON:0002315 ! gray matter of spinal cord intersection_of: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord relationship: BFO:0000050 UBERON:0003038 ! part of thoracic spinal cord -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0014702 +name: frontonasal process epithelium +def: "An epithelium that is part of a frontonasal prominence." [OBOL:automatic] +xref: EHDAA2:0004108 +xref: EMAPA:32918 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0005291 ! embryonic tissue +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence +relationship: BFO:0000050 UBERON:0004066 ! part of frontonasal prominence +relationship: RO:0002202 UBERON:0000076 ! external ectoderm + +[Term] +id: UBERON:0014703 +name: anal membrane ectodermal component +def: "A unilaminar epithelium that develops_from a ectoderm and is part of a anal region." [OBOL:automatic] +xref: EHDAA2:0004019 +xref: EMAPA:25040 +is_a: UBERON:0000490 ! unilaminar epithelium +is_a: UBERON:0010371 ! ecto-epithelium +intersection_of: UBERON:0000490 ! unilaminar epithelium +intersection_of: BFO:0000050 UBERON:0001353 ! part of anal region +intersection_of: RO:0002202 UBERON:0000924 ! ectoderm +relationship: BFO:0000050 UBERON:0001353 ! part of anal region [Term] id: UBERON:0014704 name: pleuroperitoneal canal lumen +def: "An anatomical space that is enclosed by a pleuroperitoneal canal." [OBOL:automatic] +xref: EHDAA2:0004736 +xref: EMAPA:25034 is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: RO:0002572 UBERON:0006279 ! pleuroperitoneal canal @@ -43543,26 +67427,42 @@ relationship: RO:0002572 UBERON:0006279 ! pleuroperitoneal canal [Term] id: UBERON:0014716 name: interlobular duct +def: "A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory." [ncithesaurus:Interlobular_Duct] +xref: NCIT:C32828 +xref: UMLS:C1512857 +xref: Wikipedia:Interlobular_ducts is_a: UBERON:0035050 ! excretory duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue intersection_of: RO:0002170 UBERON:0009911 ! lobule relationship: BFO:0000050 UBERON:0002384 ! part of connective tissue relationship: RO:0002170 UBERON:0009911 ! lobule -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0014717 +name: mucous acinus +def: "The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm] +xref: FMA:86278 +is_a: UBERON:0011858 ! acinus of exocrine gland +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: BFO:0000050 UBERON:0000414 ! part of mucous gland +relationship: BFO:0000050 UBERON:0000414 ! part of mucous gland +relationship: RO:0002473 CL:0000319 ! mucus secreting cell [Term] id: UBERON:0014719 name: intralobular duct +def: "A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular." [http://www.siumed.edu/~dking2/intro/glands.htm] +xref: SCTID:205214009 is_a: UBERON:0000058 ! duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0009911 ! part of lobule relationship: BFO:0000050 UBERON:0009911 ! part of lobule -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014720 name: interlobar duct +def: "A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory." [http://www.siumed.edu/~dking2/intro/glands.htm] is_a: UBERON:0035050 ! excretory duct intersection_of: UBERON:0000058 ! duct intersection_of: BFO:0000050 UBERON:0002384 ! part of connective tissue @@ -43573,6 +67473,9 @@ relationship: RO:0002176 UBERON:0009912 ! anatomical lobe [Term] id: UBERON:0014776 name: midbrain neuromere +def: "A neuromere that is part of the presumptive midbrain." [http://orcid.org/0000-0002-6601-2165] +xref: EHDAA2:0004352 +xref: FMA:61997 is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain @@ -43581,14 +67484,29 @@ relationship: BFO:0000050 UBERON:0009616 ! part of presumptive midbrain [Term] id: UBERON:0014777 name: spinal neuromere +def: "A neuromere that is part of the presumptive spinal cord." [http://orcid.org/0000-0002-6601-2165] +xref: TAO:0001332 +xref: ZFA:0001332 is_a: UBERON:0004731 ! neuromere intersection_of: UBERON:0004731 ! neuromere intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord +[Term] +id: UBERON:0014783 +name: cloacal muscle +def: "Any muscle organ that is part of a cloaca." [OBOL:automatic] +is_a: UBERON:0001630 ! muscle organ +is_a: UBERON:0013765 ! digestive system element +intersection_of: UBERON:0001630 ! muscle organ +intersection_of: BFO:0000050 UBERON:0000162 ! part of cloaca +relationship: BFO:0000050 UBERON:0000162 ! part of cloaca + [Term] id: UBERON:0014793 name: musculature of pectoral complex +def: "Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin." [OBOL:automatic] +xref: FMA:71296 is_a: UBERON:0001015 ! musculature intersection_of: UBERON:0001015 ! musculature intersection_of: BFO:0000050 UBERON:0010708 ! part of pectoral complex @@ -43597,6 +67515,7 @@ relationship: BFO:0000050 UBERON:0010708 ! part of pectoral complex [Term] id: UBERON:0014794 name: pectoral appendage muscle +def: "Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin)." [OBOL:automatic] is_a: UBERON:0010891 ! pectoral complex muscle intersection_of: UBERON:0014892 ! skeletal muscle organ, vertebrate intersection_of: BFO:0000050 UBERON:0004710 ! part of pectoral appendage @@ -43605,6 +67524,26 @@ relationship: BFO:0000050 UBERON:0007269 ! part of pectoral appendage musculatur [Term] id: UBERON:0014892 name: skeletal muscle organ, vertebrate +def: "A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles)." [GOC:dos] +xref: AAO:0011099 +xref: BTO:0001103 +xref: CALOHA:TS-0933 +xref: EFO:0000888 +xref: EHDAA:5035 +xref: EHDAA:5043 +xref: EHDAA:5978 +xref: EHDAA:5984 +xref: EMAPA:35988 +xref: EV:0100377 +xref: GAID:141 +xref: MA:0003148 +xref: MAT:0000302 +xref: MESH:D018482 +xref: MIAA:0000302 +xref: TAO:0005277 +xref: VHOG:0000319 +xref: XAO:0000174 +xref: ZFA:0005277 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: RO:0002103 CL:0000100 ! motor neuron @@ -43617,11 +67556,14 @@ relationship: RO:0002160 NCBITaxon:7742 ! Vertebrata relationship: RO:0002202 UBERON:0003082 ! myotome relationship: RO:0002219 UBERON:0011899 ! epimysium relationship: RO:0002473 UBERON:0001134 ! skeletal muscle tissue -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0014903 name: primordial vasculature +def: "A portion of tissue that will develop into vasculature." [ZFA:0005076, ZFA:curator] +xref: EFO:0003708 +xref: TAO:0005076 +xref: ZFA:0005076 is_a: UBERON:0001048 ! primordium intersection_of: UBERON:0001048 ! primordium intersection_of: RO:0002387 UBERON:0002049 ! vasculature @@ -43631,18 +67573,64 @@ relationship: RO:0002387 UBERON:0002049 ! vasculature [Term] id: UBERON:0014907 name: intersomitic vessel +def: "One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites." [MGI:anna] +xref: EFO:0003664 +xref: TAO:0001285 +xref: XAO:0004075 +xref: ZFA:0001285 is_a: UBERON:0001981 ! blood vessel relationship: RO:0002202 UBERON:0005805 ! dorsal aorta +[Term] +id: UBERON:0015007 +name: cervical vertebra endochondral element +def: "A vertebral endochondral element in the cervical region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0005174 ! dorsal region element +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: BFO:0000050 UBERON:0006072 ! part of cervical region of vertebral column +union_of: UBERON:0002413 ! cervical vertebra +union_of: UBERON:0013505 ! cervical vertebra cartilage element +union_of: UBERON:0013506 ! cervical vertebra pre-cartilage condensation +relationship: BFO:0000050 UBERON:0006072 ! part of cervical region of vertebral column + +[Term] +id: UBERON:0015008 +name: thoracic vertebra endochondral element +def: "A vertebral endochondral element in the thoracic region of the vertebral column." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0005174 ! dorsal region element +is_a: UBERON:0005181 ! thoracic segment organ +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: BFO:0000050 UBERON:0006073 ! part of thoracic region of vertebral column +union_of: UBERON:0002347 ! thoracic vertebra +union_of: UBERON:0013507 ! thoracic vertebra cartilage element +union_of: UBERON:0013508 ! thoracic vertebra pre-cartilage condensation +relationship: BFO:0000050 UBERON:0006073 ! part of thoracic region of vertebral column + +[Term] +id: UBERON:0015060 +name: sphenoid endochondral element +def: "A sphenoid bone or its cartilage or pre-cartilage precursor." [https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern] +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0010363 ! endochondral element +union_of: UBERON:0001677 ! sphenoid bone +union_of: UBERON:0009191 ! sphenoid bone pre-cartilage condensation +union_of: UBERON:0009193 ! sphenoid cartilage element +relationship: BFO:0000050 UBERON:0011156 ! part of facial skeleton + [Term] id: UBERON:0015128 name: subepicardial layer of epicardium +xref: FMA:83105 is_a: UBERON:0007188 ! mesothelium of serous pericardium relationship: BFO:0000050 UBERON:0002348 ! part of epicardium [Term] id: UBERON:0015129 name: epicardial fat +def: "Visceral intrapericardial fat contiguous with the myocardial surface." [DOI:10.5935/abc.20130138] +xref: FMA:9871 is_a: UBERON:0003837 ! thoracic segment connective tissue is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0035814 ! pericardial fat @@ -43658,6 +67646,7 @@ relationship: RO:0002473 CL:1000309 ! epicardial adipocyte [Term] id: UBERON:0015152 name: gland of ocular region +def: "A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/614] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0004088 ! part of orbital region @@ -43666,6 +67655,7 @@ relationship: BFO:0000050 UBERON:0035639 ! part of ocular adnexa [Term] id: UBERON:0015165 name: multi-unit eye +def: "An eye consisting of multiple light-sensing organs." [http://orcid.org/0000-0002-6601-2165, PMID:21062451] is_a: UBERON:0000970 ! eye intersection_of: UBERON:0000970 ! eye intersection_of: RO:0002473 UBERON:0000020 ! sense organ @@ -43674,6 +67664,10 @@ relationship: RO:0002473 UBERON:0000020 ! sense organ [Term] id: UBERON:0015178 name: somite border +def: "A region of somite adjacent to presomitic mesoderm." [http://orcid.org/0000-0002-6601-2165] +xref: TAO:0001462 +xref: XAO:0004074 +xref: ZFA:0001462 is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: BFO:0000050 UBERON:0002329 ! part of somite @@ -43684,6 +67678,8 @@ relationship: RO:0002220 UBERON:0003059 ! adjacent to presomitic mesoderm [Term] id: UBERON:0015179 name: somite boundary epithelium +def: "Epithelium located in the intersomitic region." [XAO:0004077, XAO:EJS] +xref: XAO:0004077 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0015178 ! part of somite border @@ -43692,11 +67688,15 @@ relationship: BFO:0000050 UBERON:0015178 ! part of somite border [Term] id: UBERON:0015203 name: non-connected functional system +def: "An anatomical group whose component structures share a common function." [AEO:0000093, AEO:JB, FBbt:00007278, FBC:DOS] +xref: AEO:0000093 is_a: UBERON:0034923 ! disconnected anatomical group [Term] id: UBERON:0015204 name: glandular system +def: "A non-connected functional system that is composed primarily of a gland." [OBOL:automatic] +xref: EHDAA2:0002223 is_a: UBERON:0015203 ! non-connected functional system intersection_of: UBERON:0015203 ! non-connected functional system intersection_of: RO:0002473 UBERON:0002530 ! gland @@ -43705,6 +67705,7 @@ relationship: RO:0002473 UBERON:0002530 ! gland [Term] id: UBERON:0015212 name: lateral structure +def: "Any structure that is placed on one side of the left-right axis of a bilaterian." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: BSPO:0000126 UBERON:0000465 ! material anatomical entity @@ -43714,13 +67715,38 @@ relationship: RO:0002160 NCBITaxon:33213 ! Bilateria [Term] id: UBERON:0015228 name: circulatory organ +def: "A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0003103 ! compound organ relationship: BFO:0000050 UBERON:0001009 ! part of circulatory system relationship: RO:0000086 PATO:0001690 +[Term] +id: UBERON:0015280 +name: pancreas left lobe +def: "A pancreatic lobule that is in_the_left_side_of a exocrine pancreas." [OBOL:automatic] +xref: MA:0000722 +is_a: UBERON:0007324 ! pancreatic lobule +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0007324 ! pancreatic lobule +intersection_of: BSPO:0000120 UBERON:0000017 ! exocrine pancreas +relationship: BSPO:0000120 UBERON:0000017 ! exocrine pancreas + +[Term] +id: UBERON:0015281 +name: pancreas right lobe +def: "A pancreatic lobule that is in_the_right_side_of a exocrine pancreas." [OBOL:automatic] +xref: MA:0000723 +is_a: UBERON:0007324 ! pancreatic lobule +is_a: UBERON:0015212 ! lateral structure +intersection_of: UBERON:0007324 ! pancreatic lobule +intersection_of: BSPO:0000121 UBERON:0000017 ! exocrine pancreas +relationship: BSPO:0000121 UBERON:0000017 ! exocrine pancreas + [Term] id: UBERON:0015329 name: respiratory system basement membrane +def: "A basement membrane of epithelium that is part of a respiratory system." [OBOL:automatic] +xref: MA:0001815 is_a: UBERON:0005769 ! basement membrane of epithelium intersection_of: UBERON:0005769 ! basement membrane of epithelium intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -43729,26 +67755,105 @@ relationship: BFO:0000050 UBERON:0003570 ! part of respiratory system connective [Term] id: UBERON:0015410 name: heart plus pericardium +xref: MA:0002449 is_a: UBERON:0005178 ! thoracic cavity element relationship: BFO:0000050 UBERON:0004535 ! part of cardiovascular system -property_value: RO:0002175 NCBITaxon:9606 + +[Term] +id: UBERON:0015480 +name: proper hepatic artery +def: "The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery." [Wikipedia:Hepatic_artery_proper] +xref: FMA:14772 +xref: MA:0003095 +xref: SCTID:244262006 +xref: Wikipedia:Hepatic_artery_proper +is_a: UBERON:0001193 ! hepatic artery +relationship: RO:0002252 UBERON:0005436 ! common hepatic artery + +[Term] +id: UBERON:0015481 +name: left hepatic artery +def: "A hepatic artery that is part of a left lobe of liver." [OBOL:automatic] +xref: FMA:14779 +xref: MA:0003096 +is_a: UBERON:0001193 ! hepatic artery +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001193 ! hepatic artery +intersection_of: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: BFO:0000050 UBERON:0001115 ! part of left lobe of liver +relationship: RO:0002170 UBERON:0015480 ! proper hepatic artery + +[Term] +id: UBERON:0015482 +name: right hepatic artery +def: "A hepatic artery that is part of a right lobe of liver." [OBOL:automatic] +xref: FMA:14778 +xref: MA:0003097 +is_a: UBERON:0001193 ! hepatic artery +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001193 ! hepatic artery +intersection_of: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: BFO:0000050 UBERON:0001114 ! part of right lobe of liver +relationship: RO:0002170 UBERON:0015480 ! proper hepatic artery + +[Term] +id: UBERON:0015485 +name: choledocho-duodenal junction +def: "Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla." [http://medical-dictionary.thefreedictionary.com/choledochoduodenal+junction] +xref: MA:0003108 +is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0002114 ! duodenum +intersection_of: RO:0002176 UBERON:0002394 ! bile duct +relationship: RO:0002176 UBERON:0002114 ! duodenum +relationship: RO:0002176 UBERON:0002394 ! bile duct + +[Term] +id: UBERON:0015716 +name: anal canal epithelium +def: "An epithelium that is part of a anal canal." [OBOL:automatic] +xref: EMAPA:18835 +xref: FMA:17511 +is_a: UBERON:0001278 ! epithelium of large intestine +is_a: UBERON:0014703 ! anal membrane ectodermal component +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal [Term] id: UBERON:0015757 name: heterogeneous tissue +xref: FMA:62798 is_a: UBERON:0000479 ! tissue [Term] id: UBERON:0015783 name: smooth muscle layer in fatty layer of subcutaneous tissue +def: "A smooth muscle tissue that is part of a hypodermis." [OBOL:automatic] +xref: FMA:77862 is_a: UBERON:0001135 ! smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0002072 ! part of hypodermis relationship: BFO:0000050 UBERON:0002072 ! part of hypodermis +[Term] +id: UBERON:0015796 +name: liver blood vessel +def: "A blood vessel that is part of a liver." [OBOL:automatic] +xref: EMAPA:35498 +xref: MA:0003137 +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +is_a: UBERON:0003497 ! abdomen blood vessel +intersection_of: UBERON:0001981 ! blood vessel +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: UBERON:0015808 name: eye epithelium +def: "An epithelium that is part of a camera-type eye." [OBOL:automatic] +xref: EMAPA:35957 +xref: MA:0003162 is_a: UBERON:0007625 ! pigment epithelium of eye is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium @@ -43758,23 +67863,41 @@ relationship: BFO:0000050 UBERON:0000019 ! part of camera-type eye [Term] id: UBERON:0015833 name: foregut epithelium +def: "An epithelium that is part of a foregut." [OBOL:automatic] +xref: EMAPA:32922 +xref: MA:0003204 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0001041 ! part of foregut relationship: BFO:0000050 UBERON:0001041 ! part of foregut +[Term] +id: UBERON:0015834 +name: duodenum lamina propria +def: "A lamina propria that is part of a duodenum." [OBOL:automatic] +xref: EMAPA:27255 +xref: FMA:15972 +xref: MA:0003209 +is_a: UBERON:0001238 ! lamina propria of small intestine +intersection_of: UBERON:0000030 ! lamina propria +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0008342 ! part of intestinal villus of duodenum + [Term] id: UBERON:0016405 name: pulmonary capillary +def: "A capillary that is part of a lung." [OBOL:automatic] +xref: FMA:14121 is_a: UBERON:0003512 ! lung blood vessel is_a: UBERON:0003526 ! respiratory system capillary intersection_of: UBERON:0001982 ! capillary intersection_of: BFO:0000050 UBERON:0002048 ! part of lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0016458 name: esophageal hiatus +def: "A hole in the diaphragm through which the esophagus passes." [HP:0002036] +xref: FMA:58289 is_a: UBERON:0000161 ! orifice intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0001103 ! part of diaphragm @@ -43782,9 +67905,28 @@ intersection_of: RO:0002570 UBERON:0001043 ! esophagus relationship: BFO:0000050 UBERON:0001103 ! part of diaphragm relationship: RO:0002570 UBERON:0001043 ! esophagus +[Term] +id: UBERON:0016478 +name: liver stroma +def: "A stroma that is part of a liver." [OBOL:automatic] +xref: FMA:17553 +is_a: UBERON:0003891 ! stroma +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0003891 ! stroma +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + [Term] id: UBERON:0016490 name: auditory system +def: "Is the sensory system for the sense of hearing." [NLXANAT:090817] +xref: EMAPA:36002 +xref: FMA:7192 +xref: MA:0002443 +xref: NCIT:C12889 +xref: neuronames:2888 +xref: NLXANAT:090817 +xref: Wikipedia:Auditory_system is_a: UBERON:0007037 ! mechanosensory system intersection_of: UBERON:0001032 ! sensory system intersection_of: RO:0002215 GO:0007605 ! capable of sensory perception of sound @@ -43794,14 +67936,31 @@ relationship: RO:0002215 GO:0007605 ! capable of sensory perception of sound [Term] id: UBERON:0016509 name: cavity of right ventricle +def: "Luminal space of the right ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:26047 +xref: FMA:9291 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002080 ! heart right ventricle relationship: RO:0002572 UBERON:0002080 ! heart right ventricle +[Term] +id: UBERON:0016512 +name: lumen of duodenum +def: "An anatomical space that is part of a duodenum." [OBOL:automatic] +xref: EMAPA:19080 +xref: FMA:14589 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: BFO:0000050 UBERON:0002114 ! part of duodenum +relationship: BFO:0000050 UBERON:0002114 ! part of duodenum + [Term] id: UBERON:0016513 name: cavity of left atrium +def: "Luminal space of the left atrium of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:26011 +xref: FMA:9465 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002079 ! left cardiac atrium @@ -43810,6 +67969,9 @@ relationship: RO:0002572 UBERON:0002079 ! left cardiac atrium [Term] id: UBERON:0016514 name: cavity of left ventricle +def: "Luminal space of the left ventricle of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:26038 +xref: FMA:9466 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002084 ! heart left ventricle @@ -43818,6 +67980,9 @@ relationship: RO:0002572 UBERON:0002084 ! heart left ventricle [Term] id: UBERON:0016522 name: cavity of right atrium +def: "Luminal space of the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: EMAPA:26020 +xref: FMA:11359 is_a: UBERON:0035763 ! cavity of cardiac chamber intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0002078 ! right cardiac atrium @@ -43826,6 +67991,9 @@ relationship: RO:0002572 UBERON:0002078 ! right cardiac atrium [Term] id: UBERON:0016545 name: pharyngeal ectoderm +def: "The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches." [http://orcid.org/0000-0002-6601-2165, PMID:23020903] +xref: TAO:0001379 +xref: ZFA:0001379 is_a: UBERON:0000490 ! unilaminar epithelium is_a: UBERON:0003351 ! pharyngeal epithelium is_a: UBERON:0005291 ! embryonic tissue @@ -43837,6 +68005,8 @@ relationship: BFO:0000050 UBERON:0000076 ! part of external ectoderm [Term] id: UBERON:0016548 name: central nervous system gray matter layer +def: "A layer of of the central nervous system that is part of gray matter." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:83142 is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: RO:0002473 UBERON:0002020 ! gray matter @@ -43848,18 +68018,60 @@ name: spinal cord column is_a: UBERON:0011215 ! central nervous system cell part cluster relationship: BFO:0000050 UBERON:0002240 ! part of spinal cord +[Term] +id: UBERON:0016552 +name: phlegm +def: "Mucus produced in the respiratory tract." [http://orcid.org/0000-0002-6601-2165] +xref: NCIT:C93171 +xref: UMLS:C0225378 +is_a: UBERON:0000912 ! mucus +intersection_of: UBERON:0000912 ! mucus +intersection_of: RO:0003001 UBERON:0000065 ! produced by respiratory tract +relationship: RO:0003001 UBERON:0000065 ! produced by respiratory tract + +[Term] +id: UBERON:0016553 +name: respiratory system mucus +def: "Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm)." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Nasal_mucus#Respiratory_system] +is_a: UBERON:0000912 ! mucus +intersection_of: UBERON:0000912 ! mucus +intersection_of: RO:0003001 UBERON:0004785 ! produced by respiratory system mucosa +relationship: RO:0003001 UBERON:0004785 ! produced by respiratory system mucosa + +[Term] +id: UBERON:0016566 +name: pit +def: "An roughly circular indentation in a surface." [AEO:0000204, AEO:JB] +xref: AEO:0000204 +is_a: UBERON:0036215 ! anatomical surface region + [Term] id: UBERON:0016570 name: lamina of gray matter of spinal cord +xref: FMA:68861 +xref: http://neurolex.org/wiki/Category\:Rexed_spinal_cord_parcellation_scheme_region +xref: Wikipedia:Rexed_laminae is_a: UBERON:0011215 ! central nervous system cell part cluster is_a: UBERON:0022303 ! nervous system cell part layer intersection_of: UBERON:0022303 ! nervous system cell part layer intersection_of: BFO:0000050 UBERON:0002315 ! part of gray matter of spinal cord relationship: BFO:0000050 UBERON:0002315 ! part of gray matter of spinal cord +[Term] +id: UBERON:0016854 +name: dorsal part of optic cup +def: "The dorsal region of the optic cup that gives rise to the dorsal part of the retina." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0000481 ! multi-tissue structure +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000481 ! multi-tissue structure +intersection_of: BSPO:0015101 UBERON:0003072 ! optic cup +relationship: BFO:0000050 UBERON:0003072 ! part of optic cup +relationship: BSPO:0015101 UBERON:0003072 ! optic cup + [Term] id: UBERON:0016879 name: future central nervous system +def: "Primordium that develops into the central nervous system." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001017 ! central nervous system @@ -43871,15 +68083,41 @@ relationship: RO:0002387 UBERON:0001017 ! central nervous system [Term] id: UBERON:0016880 name: future nervous system +def: "Primordium that develops into the nervous system." [http://orcid.org/0000-0002-6601-2165] +xref: AAO:0000477 is_a: UBERON:0006598 ! presumptive structure intersection_of: UBERON:0006598 ! presumptive structure intersection_of: RO:0002387 UBERON:0001016 ! nervous system relationship: RO:0002387 UBERON:0001016 ! nervous system relationship: RO:0002496 UBERON:0000111 ! organogenesis stage +[Term] +id: UBERON:0016885 +name: epithelium of terminal part of digestive tract +def: "Epithelium lining the distalmost portion of the digestive tract." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0005445 +xref: WBbt:0005800 +is_a: UBERON:0003929 ! digestive tract epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract +relationship: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract + +[Term] +id: UBERON:0016886 +name: muscle tissue of terminal part of digestive tract +def: "Any muscle tissue of the distalmost portion of the digestive tract." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0002385 ! muscle tissue +intersection_of: UBERON:0002385 ! muscle tissue +intersection_of: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract +relationship: BFO:0000050 UBERON:0006866 ! part of terminal part of digestive tract + [Term] id: UBERON:0016887 name: entire extraembryonic component +def: "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism." [AEO:0000195, AEO:JB] +xref: AEO:0000195 +xref: EHDAA2:0000003 +xref: EMAPA:16042 is_a: UBERON:0000481 ! multi-tissue structure relationship: BFO:0000050 UBERON:0004716 ! part of conceptus relationship: RO:0002220 UBERON:0002050 ! adjacent to embryonic structure @@ -43888,11 +68126,15 @@ relationship: RO:0002491 UBERON:0000068 ! embryo stage [Term] id: UBERON:0016888 name: transitional anatomical structure +def: "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development." [AEO:0000132, AEO:JB] +xref: AEO:0000132 is_a: UBERON:0005423 ! developing anatomical structure [Term] id: UBERON:0017650 name: developing mesenchymal structure +def: "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure." [AEO:0001016, AEO:JB] +xref: AEO:0001016 is_a: UBERON:0005423 ! developing anatomical structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: RO:0002473 UBERON:0003104 ! mesenchyme @@ -43901,30 +68143,94 @@ relationship: RO:0002473 UBERON:0003104 ! mesenchyme [Term] id: UBERON:0017672 name: abdominal viscera +def: "A viscus that is part of a abdomen." [OBOL:automatic] +xref: FMA:32413 +xref: FMA:67355 is_a: UBERON:0002075 ! viscus is_a: UBERON:0005172 ! abdomen element intersection_of: UBERON:0002075 ! viscus intersection_of: BFO:0000050 UBERON:0000916 ! part of abdomen +[Term] +id: UBERON:0018111 +name: muscle layer of rectum +def: "A muscle layer that is part of the rectum." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:15035 +is_a: UBERON:0011198 ! muscle layer of large intestine +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + +[Term] +id: UBERON:0018112 +name: rectum smooth muscle tissue +def: "Any portion of smooth muscle tissue that is part of the rectum." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0004220 ! large intestine smooth muscle +is_a: UBERON:0004231 ! anal region smooth muscle +is_a: UBERON:0016886 ! muscle tissue of terminal part of digestive tract +intersection_of: UBERON:0001135 ! smooth muscle tissue +intersection_of: BFO:0000050 UBERON:0001052 ! part of rectum +relationship: BFO:0000050 UBERON:0001052 ! part of rectum + [Term] id: UBERON:0018135 name: fibrocollagenous connective tissue +xref: FMA:83521 is_a: UBERON:0011824 ! fibrous connective tissue intersection_of: UBERON:0011824 ! fibrous connective tissue intersection_of: RO:0000086 PATO:0002462 relationship: RO:0000086 PATO:0002462 +[Term] +id: UBERON:0018142 +name: caudal vertebra endochondral element +def: "Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx)." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0005174 ! dorsal region element +is_a: UBERON:0010913 ! vertebral element +intersection_of: UBERON:0010913 ! vertebral element +intersection_of: BFO:0000050 UBERON:0006076 ! part of caudal region of vertebral column +union_of: UBERON:0001095 ! caudal vertebra +union_of: UBERON:0013503 ! caudal vertebra cartilage element +union_of: UBERON:0013504 ! caudal vertebra pre-cartilage condensation +relationship: BFO:0000050 UBERON:0006076 ! part of caudal region of vertebral column + [Term] id: UBERON:0018150 name: skin of lower lip +def: "A zone of skin that is part of a lower lip." [OBOL:automatic] +xref: FMA:24767 +xref: SCTID:281630002 is_a: UBERON:0001458 ! skin of lip intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001835 ! part of lower lip relationship: BFO:0000050 UBERON:0001835 ! part of lower lip +[Term] +id: UBERON:0018151 +name: skin of upper lip +def: "A zone of skin that is part of a upper lip." [OBOL:automatic] +xref: FMA:24765 +xref: SCTID:281629007 +is_a: UBERON:0001458 ! skin of lip +is_a: UBERON:1000021 ! skin of face +intersection_of: UBERON:0000014 ! zone of skin +intersection_of: BFO:0000050 UBERON:0001834 ! part of upper lip +relationship: BFO:0000050 UBERON:0001834 ! part of upper lip + +[Term] +id: UBERON:0018234 +name: stroma of pancreas +def: "A stroma that is part of a pancreas." [OBOL:automatic] +xref: FMA:63121 +is_a: UBERON:0003891 ! stroma +intersection_of: UBERON:0003891 ! stroma +intersection_of: BFO:0000050 UBERON:0001264 ! part of pancreas +relationship: BFO:0000050 UBERON:0001264 ! part of pancreas + [Term] id: UBERON:0018239 name: rhombomere boundary +def: "A boundary delimiting a rhombomere." [GO:0021654] is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction @@ -43935,14 +68241,16 @@ relationship: RO:0002176 UBERON:0001892 ! rhombomere [Term] id: UBERON:0018254 name: skeletal musculature +xref: EHDAA2:0001842 +xref: EMAPA:35578 is_a: UBERON:0000061 ! anatomical structure relationship: BFO:0000050 UBERON:0000383 ! part of musculature of body relationship: RO:0002473 UBERON:0014892 ! skeletal muscle organ, vertebrate -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0018257 name: submucosa of digestive tract +def: "Any portion of submucosa that lines the digestive tract." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000009 ! submucosa intersection_of: UBERON:0000009 ! submucosa intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract @@ -43951,14 +68259,55 @@ relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract [Term] id: UBERON:0018260 name: layer of muscle tissue +def: "Any organ component layer that consists of muscle tissue." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:45634 +xref: NCIT:C75444 +xref: UMLS:C0225358 is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002473 UBERON:0002385 ! muscle tissue relationship: RO:0002473 UBERON:0002385 ! muscle tissue +[Term] +id: UBERON:0018261 +name: muscular coat of digestive tract +def: "A muscular coat that is part of a digestive tract." [OBOL:automatic] +is_a: UBERON:0006660 ! muscular coat +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001555 ! part of digestive tract +relationship: BFO:0000050 UBERON:0001555 ! part of digestive tract +relationship: RO:0002216 GO:0030432 ! capable of part of peristalsis + +[Term] +id: UBERON:0018415 +name: ethmoid foramen +def: "An bone foramen in the ethmoid bone." [http://orcid.org/0000-0002-6601-2165] +comment: Taxon nodes: In humans, refers to anterior or posterior ethmoid foramina +xref: Wikipedia:Ethmoidal_foramina +is_a: UBERON:0010313 ! neural crest-derived structure +is_a: UBERON:0013685 ! foramen of skull +intersection_of: UBERON:0004111 ! anatomical conduit +intersection_of: BFO:0000050 UBERON:0001679 ! part of ethmoid bone +relationship: BFO:0000050 UBERON:0001679 ! part of ethmoid bone + +[Term] +id: UBERON:0018543 +name: lumen of intestine +def: "The anatomical space within the intestine." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:14586 +xref: TADS:0000495 +xref: WBbt:0005791 +xref: ZFA:0005807 +is_a: UBERON:0000464 ! anatomical space +intersection_of: UBERON:0000464 ! anatomical space +intersection_of: RO:0002572 UBERON:0000160 ! intestine +relationship: RO:0002572 UBERON:0000160 ! intestine + [Term] id: UBERON:0018544 name: trigeminal nerve muscle +def: "Muscle innervated by the trigeminal nerve (Cranial Nerve V)." [MFMO:0000072] +xref: MFMO:0000072 is_a: UBERON:0001630 ! muscle organ intersection_of: UBERON:0001630 ! muscle organ intersection_of: RO:0002005 UBERON:0001645 ! trigeminal nerve @@ -43968,6 +68317,7 @@ relationship: RO:0002202 UBERON:0004362 ! pharyngeal arch 1 [Term] id: UBERON:0018649 name: cardiac muscle tissue of ventricle +xref: FMA:83450 is_a: UBERON:0004493 ! cardiac muscle tissue of myocardium intersection_of: UBERON:0001133 ! cardiac muscle tissue intersection_of: BFO:0000050 UBERON:0002082 ! part of cardiac ventricle @@ -43976,15 +68326,39 @@ relationship: BFO:0000050 UBERON:0001083 ! part of myocardium of ventricle [Term] id: UBERON:0018674 name: heart vasculature +def: "An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart." [ZFA:0005811, ZFA:CVS] +xref: FMA:73747 +xref: ZFA:0005811 is_a: UBERON:0002201 ! vasculature of trunk is_a: UBERON:0006876 ! vasculature of organ intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0000948 ! part of heart relationship: BFO:0000050 UBERON:0000948 ! part of heart +[Term] +id: UBERON:0018692 +name: dorsal side of post-anal tail +is_a: UBERON:0034929 ! external soft tissue zone +intersection_of: UBERON:0034929 ! external soft tissue zone +intersection_of: BSPO:0015101 UBERON:0007812 ! post-anal tail +relationship: BFO:0000050 UBERON:0001137 ! part of dorsum +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BSPO:0015101 UBERON:0007812 ! post-anal tail + +[Term] +id: UBERON:0018707 +name: bladder organ +def: "A membranous sac in animals that serves as the receptacle of a liquid or contains gas." [BTO:0000123] +xref: BTO:0000123 +is_a: UBERON:0000489 ! cavitated compound organ +is_a: UBERON:0009856 ! sac +relationship: RO:0000086 PATO:0002468 +relationship: RO:0001015 UBERON:0000463 ! organism substance + [Term] id: UBERON:0019042 name: reproductive system mucosa +xref: BTO:0002439 is_a: UBERON:0000344 ! mucosa is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000344 ! mucosa @@ -43993,6 +68367,8 @@ intersection_of: BFO:0000050 UBERON:0000990 ! part of reproductive system [Term] id: UBERON:0019143 name: intramuscular adipose tissue +def: "Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes." [BTO:0004043] +xref: BTO:0004043 is_a: UBERON:0001013 ! adipose tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: BFO:0000050 UBERON:0014892 ! part of skeletal muscle organ, vertebrate @@ -44001,14 +68377,31 @@ relationship: BFO:0000050 UBERON:0014892 ! part of skeletal muscle organ, verteb [Term] id: UBERON:0019189 name: carotid artery endothelium +xref: BTO:0004626 is_a: UBERON:0001917 ! endothelium of artery intersection_of: UBERON:0001986 ! endothelium intersection_of: BFO:0000050 UBERON:0005396 ! part of carotid artery segment relationship: BFO:0000050 UBERON:0005396 ! part of carotid artery segment +[Term] +id: UBERON:0019190 +name: mucous gland of lung +xref: BTO:0004638 +xref: FMA:13119 +xref: SCTID:88410004 +is_a: UBERON:0000414 ! mucous gland +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0005181 ! thoracic segment organ +is_a: UBERON:0036225 ! respiratory system gland +intersection_of: UBERON:0000414 ! mucous gland +intersection_of: BFO:0000050 UBERON:0002048 ! part of lung +relationship: BFO:0000050 UBERON:0002048 ! part of lung + [Term] id: UBERON:0019204 name: skin epithelium +def: "Any region of epithelium that is part of a skin region." [http://orcid.org/0000-0002-6601-2165] +xref: BTO:0004382 is_a: UBERON:0010371 ! ecto-epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000014 ! part of zone of skin @@ -44017,6 +68410,8 @@ relationship: BFO:0000050 UBERON:0000014 ! part of zone of skin [Term] id: UBERON:0019207 name: chorioretinal region +def: "The part of the eye that consists of both the retina and the optic choroid." [http://orcid.org/0000-0002-6601-2165, UBERON:drseb] +xref: SCTID:110701000 is_a: UBERON:0000481 ! multi-tissue structure is_a: UBERON:0004121 ! ectoderm-derived structure is_a: UBERON:0010314 ! structure with developmental contribution from neural crest @@ -44027,24 +68422,28 @@ relationship: BFO:0000051 UBERON:0001776 ! has part optic choroid [Term] id: UBERON:0019263 name: gray matter of hindbrain +xref: DHBA:10654 +xref: FMA:268630 is_a: UBERON:0003528 ! brain gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0002028 ! part of hindbrain relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0019267 name: gray matter of midbrain +xref: DHBA:10649 +xref: FMA:83913 is_a: UBERON:0003528 ! brain gray matter intersection_of: UBERON:0002020 ! gray matter intersection_of: BFO:0000050 UBERON:0001891 ! part of midbrain relationship: BFO:0000050 UBERON:0001891 ! part of midbrain -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0019304 name: sensory organ epithelium +xref: EMAPA:35952 +xref: MA:0003174 is_a: UBERON:0000483 ! epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000020 ! part of sense organ @@ -44053,6 +68452,7 @@ relationship: BFO:0000050 UBERON:0000020 ! part of sense organ [Term] id: UBERON:0019319 name: exocrine gland of integumental system +def: "An exocrine gland that is part of a integumental system." [GOC:dos, http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002365 ! exocrine gland is_a: UBERON:0003297 ! gland of integumental system intersection_of: UBERON:0002365 ! exocrine gland @@ -44061,14 +68461,27 @@ intersection_of: BFO:0000050 UBERON:0002416 ! part of integumental system [Term] id: UBERON:0022288 name: surface of eyeball +xref: FMA:58315 is_a: UBERON:0036215 ! anatomical surface region intersection_of: UBERON:0036215 ! anatomical surface region intersection_of: RO:0002007 UBERON:0010230 ! bounding layer of eyeball of camera-type eye relationship: RO:0002007 UBERON:0010230 ! bounding layer of eyeball of camera-type eye +[Term] +id: UBERON:0022292 +name: splenic arteriole +xref: NCIT:C33596 +xref: SCTID:282511007 +is_a: UBERON:0001980 ! arteriole +is_a: UBERON:0003497 ! abdomen blood vessel +intersection_of: UBERON:0001980 ! arteriole +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + [Term] id: UBERON:0022293 name: reproductive gland secretion +def: "A portion of organism substance that is secreted by a reproductive gland." [UBERON:cjm] is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0003001 UBERON:0003937 ! produced by reproductive gland @@ -44077,6 +68490,8 @@ relationship: RO:0003001 UBERON:0003937 ! produced by reproductive gland [Term] id: UBERON:0022303 name: nervous system cell part layer +def: "Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]." [NLX:149357] +xref: NLX:149357 is_a: UBERON:0005162 ! multi cell part structure intersection_of: UBERON:0005162 ! multi cell part structure intersection_of: BFO:0000050 UBERON:0001016 ! part of nervous system @@ -44087,6 +68502,8 @@ relationship: RO:0000086 PATO:0002124 [Term] id: UBERON:0022350 name: visceral serous membrane +def: "Serous membrane layer that is adjacent to and lines an organ." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:15860 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -44098,6 +68515,9 @@ relationship: RO:0002220 UBERON:0000062 ! adjacent to organ [Term] id: UBERON:0022351 name: parietal serous membrane +def: "Serous membrane layer that lines to a body cavity." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:15859 +xref: MA:0002448 is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0004923 ! organ component layer intersection_of: UBERON:0004923 ! organ component layer @@ -44109,6 +68529,8 @@ relationship: RO:0002220 UBERON:0002553 ! adjacent to anatomical cavity [Term] id: UBERON:0022361 name: lung field +def: "A specific region of the foregut into the area in which the lung will develop." [GOC:dph, GOC:mtg_lung] +xref: SCTID:34922002 is_a: UBERON:0004119 ! endoderm-derived structure is_a: UBERON:0007688 ! anlage intersection_of: UBERON:0007688 ! anlage @@ -44119,23 +68541,34 @@ relationship: RO:0002387 UBERON:0002048 ! lung [Term] id: UBERON:0034705 name: developing neuroepithelium +def: "An embryonic or larval epithelium that is committed to form part of the nervous system." [AEO:0001008, AEO:JB] +xref: AEO:0001008 +xref: BTO:0000314 +xref: EHDAA2_RETIRED:0004654 +xref: FMA:64807 is_a: UBERON:0000483 ! epithelium relationship: BFO:0000050 UBERON:0001016 ! part of nervous system [Term] id: UBERON:0034706 name: proliferating neuroepithelium +def: "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells." [AEO:0001009] +xref: AEO:0001009 is_a: UBERON:0034705 ! developing neuroepithelium [Term] id: UBERON:0034707 name: differentiating neuroepithelium +def: "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells." [AEO:0001010] +xref: AEO:0001010 is_a: UBERON:0034705 ! developing neuroepithelium relationship: BFO:0000051 CL:0000031 ! has part neuroblast (sensu Vertebrata) [Term] id: UBERON:0034709 name: hindbrain marginal layer +xref: DHBA:12694 +xref: EMAPA:32916 is_a: UBERON:0004062 ! neural tube marginal layer is_a: UBERON:0011215 ! central nervous system cell part cluster intersection_of: UBERON:0004062 ! neural tube marginal layer @@ -44145,6 +68578,8 @@ relationship: BFO:0000050 UBERON:0002028 ! part of hindbrain [Term] id: UBERON:0034710 name: spinal cord ventricular layer +xref: EHDAA2:0001267 +xref: EMAPA:17585 is_a: UBERON:0004060 ! neural tube ventricular layer intersection_of: UBERON:0004060 ! neural tube ventricular layer intersection_of: BFO:0000050 UBERON:0006241 ! part of future spinal cord @@ -44154,40 +68589,48 @@ relationship: BFO:0000050 UBERON:0006241 ! part of future spinal cord [Term] id: UBERON:0034713 name: cranial neuron projection bundle +def: "Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain." [http://orcid.org/0000-0002-6601-2165, ISBN:0471888893] is_a: UBERON:0000122 ! neuron projection bundle is_a: UBERON:0015212 ! lateral structure relationship: BSPO:0000126 UBERON:0000033 ! head relationship: extends_fibers_into UBERON:0000955 ! brain relationship: RO:0002160 NCBITaxon:89593 ! Craniata -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0034728 name: autonomic nerve +def: "The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa." [Wikipedia:Autonomic_nerve] +xref: FMA:5866 +xref: MESH:D017776 +xref: SCTID:276145003 +xref: Wikipedia:Autonomic_nerve is_a: UBERON:0011779 ! nerve of head region relationship: BFO:0000050 UBERON:0002410 ! part of autonomic nervous system relationship: extends_fibers_into UBERON:0001805 ! autonomic ganglion relationship: RO:0002380 UBERON:0036264 ! zygomaticotemporal nerve -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0034729 name: sympathetic nerve +xref: SCTID:181098007 is_a: UBERON:0001021 ! nerve intersection_of: UBERON:0001021 ! nerve intersection_of: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system relationship: BFO:0000050 UBERON:0000013 ! part of sympathetic nervous system relationship: extends_fibers_into UBERON:0001806 ! sympathetic ganglion -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0034769 name: lymphomyeloid tissue +xref: FMA:79770 +xref: NCIT:C41168 is_a: UBERON:0015757 ! heterogeneous tissue [Term] id: UBERON:0034873 name: bodily gas +def: "Any substance in the body or expelled from the body that is in a gaseous state." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:84580 is_a: UBERON:0000463 ! organism substance intersection_of: UBERON:0000463 ! organism substance intersection_of: RO:0000086 PATO:0001547 @@ -44196,6 +68639,8 @@ relationship: RO:0000086 PATO:0001547 [Term] id: UBERON:0034874 name: air in respiratory system +def: "Any portion of gas located in a part of the respiratory system that is composed primarily of air." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:84581 is_a: UBERON:0034947 ! gas in respiratory system intersection_of: UBERON:0034873 ! bodily gas intersection_of: RO:0001025 UBERON:0001004 ! respiratory system @@ -44205,6 +68650,7 @@ relationship: RO:0002473 CHEBI:25805 [Term] id: UBERON:0034878 name: prechordal mesoderm +def: "The area of axial mesoderm that develops into the prechordal plate." [MGI:anna] is_a: UBERON:0002050 ! embryonic structure intersection_of: UBERON:0005423 ! developing anatomical structure intersection_of: BFO:0000050 UBERON:0003068 ! part of axial mesoderm @@ -44215,6 +68661,10 @@ relationship: RO:0002387 UBERON:0003063 ! prechordal plate [Term] id: UBERON:0034903 name: left atrium endocardium +def: "Endocardium that is part of the left atrium." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:7286 +xref: SCTID:190064008 +xref: VHOG:0001226 is_a: UBERON:0002166 ! endocardium of atrium intersection_of: UBERON:0002165 ! endocardium intersection_of: BFO:0000050 UBERON:0002079 ! part of left cardiac atrium @@ -44231,44 +68681,41 @@ relationship: RO:0002572 UBERON:0002530 ! gland [Term] id: UBERON:0034921 name: multi organ part structure +def: "An multicellular anatomical structure that has subparts of multiple organs as a part." [CARO:0020001] +xref: CARO:0020001 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: RO:0002473 UBERON:0000064 ! organ part -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0034922 name: cell cluster +def: "A cluster of cells, largely surrounded by a morphological boundary." [CARO:0020002] +xref: CARO:0020002 +xref: FMA:62807 is_a: UBERON:0010000 ! multicellular anatomical structure relationship: RO:0002219 UBERON:0000015 ! non-material anatomical boundary -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0034923 name: disconnected anatomical group +def: "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other." [CARO:0020000] +xref: CARO:0020000 is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0000086 PATO:0010001 relationship: RO:0002180 UBERON:0000061 {minCardinality="2"} ! has component anatomical structure relationship: RO:0002473 UBERON:0000061 ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0034925 name: anatomical collection +def: "A collection of anatomical structures that are alike in terms of their morphology or developmental origin." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002351 UBERON:0000061 ! anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0034929 name: external soft tissue zone +def: "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0010000 ! multicellular anatomical structure relationship: BFO:0000050 UBERON:0000475 ! part of organism subdivision relationship: BFO:0000051 UBERON:0000014 ! has part zone of skin @@ -44276,9 +68723,20 @@ relationship: BFO:0000051 UBERON:0001015 ! has part musculature relationship: BFO:0000051 UBERON:0001021 ! has part nerve relationship: BFO:0000051 UBERON:0002049 ! has part vasculature +[Term] +id: UBERON:0034932 +name: epithelium of biliary system +def: "The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts." [BTO:0001513, http://orcid.org/0000-0002-6601-2165, MGI:cs] +xref: BTO:0001513 +is_a: UBERON:0000483 ! epithelium +intersection_of: UBERON:0000483 ! epithelium +intersection_of: BFO:0000050 UBERON:0002294 ! part of biliary system +relationship: BFO:0000050 UBERON:0002294 ! part of biliary system + [Term] id: UBERON:0034933 name: layer of smooth muscle tissue +def: "Any organ component layer that consists of smooth muscle tissue." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0018260 ! layer of muscle tissue intersection_of: UBERON:0004923 ! organ component layer intersection_of: RO:0002473 UBERON:0001135 ! smooth muscle tissue @@ -44287,11 +68745,33 @@ relationship: RO:0002473 UBERON:0001135 ! smooth muscle tissue [Term] id: UBERON:0034944 name: zone of organ +xref: FMA:55268 is_a: UBERON:0000064 ! organ part +[Term] +id: UBERON:0034945 +name: excreted gas +def: "Any gaseous product of an excretory process." [http://orcid.org/0000-0002-6601-2165] +is_a: UBERON:0000174 ! excreta +is_a: UBERON:0034873 ! bodily gas +intersection_of: UBERON:0034873 ! bodily gas +intersection_of: RO:0002353 GO:0007588 ! output of excretion + +[Term] +id: UBERON:0034946 +name: gas excreted from digestive tract +def: "Any excreted gas that is produced by the digestive tract." [http://orcid.org/0000-0002-6601-2165] +comment: In mammals, mostly produced as a byproduct of bacterial fermentation in the gastrointestinal (GI) tract, especially the colon, and excreted through the rectum +xref: FMA:78440 +is_a: UBERON:0034945 ! excreted gas +intersection_of: UBERON:0034945 ! excreted gas +intersection_of: RO:0003001 UBERON:0001555 ! produced by digestive tract +relationship: RO:0003001 UBERON:0001555 ! produced by digestive tract + [Term] id: UBERON:0034947 name: gas in respiratory system +def: "Any portion of gas located in a part of the respiratory system." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0034873 ! bodily gas intersection_of: UBERON:0034873 ! bodily gas intersection_of: RO:0001025 UBERON:0001004 ! respiratory system @@ -44300,6 +68780,8 @@ relationship: RO:0001025 UBERON:0001004 ! respiratory system [Term] id: UBERON:0034969 name: epithelial layer of duct +xref: NCIT:C25787 +xref: UMLS:C1512086 is_a: UBERON:0003914 ! epithelial tube intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0000058 ! part of duct @@ -44308,6 +68790,9 @@ relationship: BFO:0000050 UBERON:0000058 ! part of duct [Term] id: UBERON:0034995 name: jaw mesenchyme +def: "Mesenchyme that is part of a developing jaw [Automatically generated definition]." [OBOL:automatic] +xref: EMAPA:32907 +xref: EMAPA:35454 is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: BFO:0000050 UBERON:0011595 ! part of jaw region @@ -44316,11 +68801,22 @@ relationship: BFO:0000050 UBERON:0011595 ! part of jaw region [Term] id: UBERON:0035037 name: jaw epithelium +xref: EMAPA:32904 +xref: MA:0003220 is_a: UBERON:0003929 ! digestive tract epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: BFO:0000050 UBERON:0011595 ! part of jaw region relationship: BFO:0000050 UBERON:0011595 ! part of jaw region +[Term] +id: UBERON:0035039 +name: rectal artery +xref: SCTID:277967008 +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0001052 ! rectum +relationship: RO:0002178 UBERON:0001052 ! rectum + [Term] id: UBERON:0035050 name: excretory duct @@ -44329,6 +68825,7 @@ is_a: UBERON:0000058 ! duct [Term] id: UBERON:0035118 name: material entity in digestive tract +def: "Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included." [https://github.com/EnvironmentOntology/envo/issues/110] is_a: UBERON:0000061 ! anatomical structure intersection_of: UBERON:0000061 ! anatomical structure intersection_of: RO:0001025 UBERON:0006909 ! lumen of digestive tract @@ -44337,6 +68834,11 @@ relationship: RO:0001025 UBERON:0006909 ! lumen of digestive tract [Term] id: UBERON:0035159 name: entire surface of organism +def: "Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface." [FMA:61695] +xref: FMA:61695 +xref: NCIT:C29667 +xref: SCTID:261060002 +xref: UMLS:C0489451 is_a: UBERON:0006984 ! anatomical surface intersection_of: UBERON:0006984 ! anatomical surface intersection_of: RO:0002221 UBERON:0000468 ! multicellular organism @@ -44345,6 +68847,10 @@ relationship: RO:0002221 UBERON:0000468 ! multicellular organism [Term] id: UBERON:0035398 name: branch of external carotid artery +xref: FMA:70505 +xref: NCIT:C32552 +xref: SCTID:244216003 +xref: UMLS:C0447038 is_a: UBERON:0001637 ! artery intersection_of: UBERON:0001637 ! artery intersection_of: RO:0002252 UBERON:0001070 ! external carotid artery @@ -44353,6 +68859,11 @@ relationship: RO:0002252 UBERON:0001070 ! external carotid artery [Term] id: UBERON:0035539 name: esophageal artery +def: "Any of several arteries that arise from the aorta and supply blood to the esophagus." [ncithesaurus:Esophageal_Artery] +xref: FMA:4149 +xref: NCIT:C32535 +xref: SCTID:56548006 +xref: UMLS:C0226294 is_a: UBERON:0003834 ! thoracic segment blood vessel is_a: UBERON:0004573 ! systemic artery intersection_of: UBERON:0001637 ! artery @@ -44360,29 +68871,46 @@ intersection_of: RO:0002178 UBERON:0001043 ! esophagus relationship: RO:0002170 UBERON:0002345 ! descending thoracic aorta relationship: RO:0002178 UBERON:0001043 ! esophagus relationship: RO:0002380 UBERON:0001515 ! thoracic aorta -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035546 name: uveal vein +xref: FMA:51797 +xref: SCTID:149683007 is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: RO:0002179 UBERON:0001768 ! uvea relationship: RO:0002179 UBERON:0001768 ! uvea +[Term] +id: UBERON:0035548 +name: colic artery +xref: SCTID:77852007 +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0001155 ! colon +relationship: RO:0002178 UBERON:0001155 ! colon + [Term] id: UBERON:0035549 name: vasculature of integument +def: "The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:225275 is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: RO:0001025 UBERON:0002199 ! integument relationship: RO:0001025 UBERON:0002199 ! integument relationship: RO:0002216 GO:0001659 ! capable of part of temperature homeostasis -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:0035550 name: superficial vein +def: "Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers." [ncithesaurus:Superficial_Vein] +xref: FMA:76719 +xref: NCIT:C33666 +xref: SCTID:341382008 +xref: UMLS:C0226513 +xref: Wikipedia:Superficial_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0035549 ! part of vasculature of integument @@ -44391,6 +68919,7 @@ relationship: BFO:0000050 UBERON:0035549 ! part of vasculature of integument [Term] id: UBERON:0035551 name: deep vasculature +def: "The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin." [http://orcid.org/0000-0002-6601-2165] is_a: UBERON:0002049 ! vasculature intersection_of: UBERON:0002049 ! vasculature intersection_of: BSPO:0000107 UBERON:0002199 ! integument @@ -44399,6 +68928,12 @@ relationship: BSPO:0000107 UBERON:0002199 ! integument [Term] id: UBERON:0035552 name: deep vein +def: "A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery." [ncithesaurus:Deep_Vein] +xref: FMA:76718 +xref: NCIT:C32444 +xref: SCTID:341484008 +xref: UMLS:C0226514 +xref: Wikipedia:Deep_vein is_a: UBERON:0001638 ! vein intersection_of: UBERON:0001638 ! vein intersection_of: BFO:0000050 UBERON:0035551 ! part of deep vasculature @@ -44407,6 +68942,9 @@ relationship: BFO:0000050 UBERON:0035551 ! part of deep vasculature [Term] id: UBERON:0035553 name: left cardiac chamber +def: "Any chamber of the left side of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:7166 +xref: SCTID:362008007 is_a: UBERON:0004151 ! cardiac chamber is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0004151 ! cardiac chamber @@ -44416,6 +68954,9 @@ relationship: BSPO:0000120 UBERON:0000948 ! heart [Term] id: UBERON:0035554 name: right cardiac chamber +def: "Any chamber of the right side of the heart." [http://orcid.org/0000-0002-6601-2165] +xref: FMA:7165 +xref: SCTID:362007002 is_a: UBERON:0004151 ! cardiac chamber is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0004151 ! cardiac chamber @@ -44425,12 +68966,20 @@ relationship: BSPO:0000121 UBERON:0000948 ! heart [Term] id: UBERON:0035639 name: ocular adnexa +def: "The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva." [HPO:pr, http://medical-dictionary.thefreedictionary.com/ocular+adnexa, https://github.com/obophenotype/uberon/issues/1132, UBERON:cjm] +xref: FMA:76554 +xref: NCIT:C32574 +xref: SCTID:120612006 +xref: UMLS:C0229243 +xref: Wikipedia:Accessory_visual_structures is_a: UBERON:0034921 ! multi organ part structure relationship: BFO:0000050 UBERON:0004088 ! part of orbital region [Term] id: UBERON:0035763 name: cavity of cardiac chamber +xref: EHDAA2:0004181 +xref: FMA:9464 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0004151 ! cardiac chamber @@ -44440,6 +68989,9 @@ relationship: RO:0002572 UBERON:0004151 ! cardiac chamber [Term] id: UBERON:0035767 name: intrapulmonary bronchus +xref: FMA:223208 +xref: NCIT:C12930 +xref: UMLS:C1512970 is_a: UBERON:0002185 ! bronchus intersection_of: UBERON:0002185 ! bronchus intersection_of: BFO:0000050 UBERON:0002048 ! part of lung @@ -44448,14 +69000,28 @@ relationship: BFO:0000050 UBERON:0002048 ! part of lung [Term] id: UBERON:0035804 name: future mouth +def: "The primordial mouth region of the developing head." [MP:0003119] +xref: FMA:293105 is_a: UBERON:0013522 ! subdivision of tube relationship: BFO:0000050 UBERON:0007026 ! part of presumptive gut relationship: BFO:0000051 UBERON:0000925 ! has part endoderm relationship: BFO:0000051 UBERON:0000930 ! has part stomodeum +[Term] +id: UBERON:0035805 +name: muscle layer of sigmoid colon +def: "A muscle layer that is part of the sigmoid colon." [https://github.com/obophenotype/uberon/issues/1162] +xref: FMA:15028 +is_a: UBERON:0012489 ! muscle layer of colon +intersection_of: UBERON:0006660 ! muscular coat +intersection_of: BFO:0000050 UBERON:0001159 ! part of sigmoid colon +relationship: BFO:0000050 UBERON:0001159 ! part of sigmoid colon + [Term] id: UBERON:0035809 name: serous cavity +xref: FMA:12241 +xref: SCTID:304404008 is_a: UBERON:0002553 ! anatomical cavity intersection_of: UBERON:0002553 ! anatomical cavity intersection_of: RO:0002572 UBERON:0005906 ! serous sac @@ -44464,6 +69030,9 @@ relationship: RO:0002572 UBERON:0005906 ! serous sac [Term] id: UBERON:0035814 name: pericardial fat +def: "The sum of epicardial and paracardial fat deposits." [DOI:10.5935/abc.20130138] +xref: SCTID:42267001 +xref: ZFA:0005765 is_a: UBERON:0035818 ! visceral fat intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002221 UBERON:0000948 ! heart @@ -44472,6 +69041,7 @@ relationship: RO:0002221 UBERON:0000948 ! heart [Term] id: UBERON:0035815 name: paracardial fat +def: "Fat deposits in the mediastinum outside the parietal pericardium ." [DOI:10.5935/abc.20130138] is_a: UBERON:0035814 ! pericardial fat intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002220 UBERON:0002408 ! adjacent to parietal serous pericardium @@ -44481,6 +69051,7 @@ relationship: RO:0002220 UBERON:0002408 ! adjacent to parietal serous pericardiu [Term] id: UBERON:0035818 name: visceral fat +def: "Any fat deposit surrounding a visceral organ." [UBERON:cjm] is_a: UBERON:0001013 ! adipose tissue intersection_of: UBERON:0001013 ! adipose tissue intersection_of: RO:0002221 UBERON:0000062 ! organ @@ -44489,6 +69060,9 @@ relationship: RO:0002221 UBERON:0000062 ! organ [Term] id: UBERON:0035819 name: abdominopelvic cavity +def: "The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity." [UBERON:cjm] +xref: FMA:12267 +xref: Wikipedia:Abdominopelvic_cavity is_a: UBERON:0000464 ! anatomical space intersection_of: UBERON:0000464 ! anatomical space intersection_of: BFO:0000050 UBERON:0002323 ! part of coelemic cavity lumen @@ -44499,6 +69073,9 @@ relationship: RO:0002572 UBERON:0002417 ! abdominal segment of trunk [Term] id: UBERON:0035820 name: peritoneal sac +def: "A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity." [https://github.com/obophenotype/uberon/issues/86] +xref: EMAPA:16137 +xref: FMA:9908 is_a: UBERON:0002075 ! viscus is_a: UBERON:0005906 ! serous sac relationship: BFO:0000051 UBERON:0001179 ! has part peritoneal cavity @@ -44508,6 +69085,8 @@ relationship: RO:0001025 UBERON:0003684 ! abdominal cavity [Term] id: UBERON:0035965 name: wall of blood vessel +xref: BTO:0004378 +xref: FMA:67473 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall @@ -44518,6 +69097,7 @@ relationship: RO:0002473 UBERON:0004797 ! blood vessel layer [Term] id: UBERON:0036072 name: respiratory primordium epithelium +xref: EHDAA2:0004070 is_a: UBERON:0004185 ! endodermal part of digestive tract is_a: UBERON:0005911 ! endo-epithelium is_a: UBERON:0007499 ! epithelial sac @@ -44531,6 +69111,7 @@ relationship: RO:0002202 UBERON:0007690 ! early pharyngeal endoderm [Term] id: UBERON:0036073 name: respiratory primordium mesenchyme +xref: EHDAA2:0004071 is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure is_a: UBERON:0003104 ! mesenchyme intersection_of: UBERON:0003104 ! mesenchyme @@ -44541,6 +69122,7 @@ relationship: RO:0002202 UBERON:0004873 ! splanchnopleure [Term] id: UBERON:0036146 name: cardiopharyngeal field +def: "An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles." [http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1, https://orcid.org/0000-0003-3308-6245] is_a: UBERON:0002050 ! embryonic structure is_a: UBERON:0004120 ! mesoderm-derived structure is_a: UBERON:0005291 ! embryonic tissue @@ -44549,23 +69131,39 @@ is_a: UBERON:0007688 ! anlage [Term] id: UBERON:0036186 name: fibroelastic connective tissue +xref: FMA:83520 is_a: UBERON:0002521 ! elastic tissue is_a: UBERON:0011824 ! fibrous connective tissue intersection_of: UBERON:0011824 ! fibrous connective tissue intersection_of: RO:0002473 GO:0071953 ! elastic fiber +[Term] +id: UBERON:0036214 +name: rectosigmoid junction +def: "An anatomical junction that is between the sigmoid colon and rectum." [https://github.com/obophenotype/uberon/issues/1319, https://www.cdc.gov/cancer/npcr/pdf/abstracting/colon.pdf, NCIT:C54188] +xref: NCIT:C54188 +xref: SCTID:245429006 +is_a: UBERON:8410024 ! intestinal junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: RO:0002176 UBERON:0001052 ! rectum +intersection_of: RO:0002176 UBERON:0001159 ! sigmoid colon +relationship: RO:0002176 UBERON:0001052 ! rectum +relationship: RO:0002176 UBERON:0001159 ! sigmoid colon + [Term] id: UBERON:0036215 name: anatomical surface region +def: "Material anatomical entity that forms the outermost boundary of an anatomical structure." [https://github.com/obophenotype/uberon/issues/1324] +xref: AAO:0010270 +xref: ZFA:0005594 is_a: UBERON:0000465 ! material anatomical entity relationship: RO:0002007 UBERON:0000061 ! bounding layer of anatomical structure -property_value: RO:0002175 NCBITaxon:33090 -property_value: RO:0002175 NCBITaxon:33208 -property_value: RO:0002175 NCBITaxon:4751 [Term] id: UBERON:0036217 name: coelomic fluid +def: "A bodily fluid that is located in the coelom." [https://github.com/obophenotype/uberon/issues/1326, PMID:10874572] +xref: BTO:0001708 is_a: UBERON:0006314 ! bodily fluid intersection_of: UBERON:0006314 ! bodily fluid intersection_of: RO:0001025 UBERON:0011997 ! coelom @@ -44574,6 +69172,7 @@ relationship: RO:0001025 UBERON:0011997 ! coelom [Term] id: UBERON:0036225 name: respiratory system gland +def: "Any gland that is part os the respiratory system." [UBERON:cjm] is_a: UBERON:0002530 ! gland intersection_of: UBERON:0002530 ! gland intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -44582,19 +69181,17 @@ relationship: BFO:0000050 UBERON:0001004 ! part of respiratory system [Term] id: UBERON:0036242 name: post-embryonic notochord +def: "A notochord that has persisted beyond the embryonic stage." [UBERON:cjm] is_a: UBERON:0002328 ! notochord intersection_of: UBERON:0002328 ! notochord intersection_of: BFO:0000050 UBERON:0009953 ! part of post-embryonic organism relationship: BFO:0000050 UBERON:0009953 ! part of post-embryonic organism -property_value: RO:0002175 NCBITaxon:118072 -property_value: RO:0002175 NCBITaxon:7737 -property_value: RO:0002175 NCBITaxon:7746 -property_value: RO:0002175 NCBITaxon:7878 -property_value: RO:0002175 NCBITaxon:8292 [Term] id: UBERON:0036244 name: secretion of serous membrane +def: "A transudate found in the serous sac." [FMA:20932] +xref: FMA:20932 is_a: UBERON:0007779 ! transudate intersection_of: UBERON:0007779 ! transudate intersection_of: filtered_through UBERON:0000042 ! serous membrane @@ -44604,6 +69201,7 @@ relationship: RO:0001025 UBERON:0005906 ! serous sac [Term] id: UBERON:0036253 name: orifice of skull +xref: FMA:53133 is_a: UBERON:0000161 ! orifice intersection_of: UBERON:0000161 ! orifice intersection_of: BFO:0000050 UBERON:0003129 ! part of skull @@ -44612,12 +69210,18 @@ relationship: BFO:0000050 UBERON:0003129 ! part of skull [Term] id: UBERON:0036264 name: zygomaticotemporal nerve +def: "The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit." [Wikipedia:Zygomaticotemporal_nerve] +xref: FMA:52972 +xref: SCTID:280243001 +xref: Wikipedia:Zygomaticotemporal_nerve is_a: UBERON:0011779 ! nerve of head region relationship: RO:0002380 UBERON:0000377 ! maxillary nerve [Term] id: UBERON:0036285 name: wall of left ventricle +def: "Wall of ventricle which is continuous with the wall of aorta." [FMA:9556] +xref: FMA:9556 is_a: UBERON:0004784 ! heart ventricle wall intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BFO:0000050 UBERON:0002084 ! part of heart left ventricle @@ -44626,6 +69230,8 @@ relationship: BFO:0000050 UBERON:0002084 ! part of heart left ventricle [Term] id: UBERON:0036286 name: wall of right ventricle +def: "Wall of ventricle which is continuous with the wall of pulmonary trunk." [FMA:9533] +xref: FMA:9533 is_a: UBERON:0004784 ! heart ventricle wall intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BFO:0000050 UBERON:0002080 ! part of heart right ventricle @@ -44634,6 +69240,7 @@ relationship: BFO:0000050 UBERON:0002080 ! part of heart right ventricle [Term] id: UBERON:0036288 name: anterior wall of left ventricle +xref: FMA:9560 is_a: UBERON:0036285 ! wall of left ventricle intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BSPO:0000123 UBERON:0002084 ! heart left ventricle @@ -44643,6 +69250,8 @@ relationship: BSPO:0000123 UBERON:0002084 ! heart left ventricle [Term] id: UBERON:0036289 name: anterior wall of right ventricle +def: "Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle." [FMA:9553] +xref: FMA:9553 is_a: UBERON:0036286 ! wall of right ventricle intersection_of: UBERON:0004784 ! heart ventricle wall intersection_of: BSPO:0000123 UBERON:0002080 ! heart right ventricle @@ -44651,6 +69260,7 @@ relationship: BSPO:0000123 UBERON:0002080 ! heart right ventricle [Term] id: UBERON:0036290 name: myocardium of anterior wall of left ventricle +xref: FMA:87177 is_a: UBERON:0006566 ! left ventricle myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0036288 ! part of anterior wall of left ventricle @@ -44659,6 +69269,7 @@ relationship: BFO:0000050 UBERON:0036288 ! part of anterior wall of left ventric [Term] id: UBERON:0036291 name: myocardium of anterior wall of right ventricle +xref: FMA:260877 is_a: UBERON:0006567 ! right ventricle myocardium intersection_of: UBERON:0002349 ! myocardium intersection_of: BFO:0000050 UBERON:0036289 ! part of anterior wall of right ventricle @@ -44667,11 +69278,24 @@ relationship: BFO:0000050 UBERON:0036289 ! part of anterior wall of right ventri [Term] id: UBERON:0036294 name: mucosa of lip +def: "A mucosa that is part of a lip region [Automatically generated definition]." [OBOL:automatic] +xref: NCIT:C12226 is_a: UBERON:0003729 ! mouth mucosa intersection_of: UBERON:0000344 ! mucosa intersection_of: BFO:0000050 UBERON:0001833 ! part of lip relationship: BFO:0000050 UBERON:0001833 ! part of lip +[Term] +id: UBERON:0036301 +name: vasculature of spleen +xref: FMA:225251 +xref: SCTID:297287005 +is_a: UBERON:0002201 ! vasculature of trunk +is_a: UBERON:0006876 ! vasculature of organ +intersection_of: UBERON:0002049 ! vasculature +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + [Term] id: UBERON:0036302 name: vasculature of central nervous system plus retina @@ -44682,14 +69306,26 @@ union_of: UBERON:0036303 ! vasculature of central nervous system [Term] id: UBERON:0036303 name: vasculature of central nervous system +xref: FMA:259905 is_a: UBERON:0036302 ! vasculature of central nervous system plus retina intersection_of: UBERON:0002049 ! vasculature intersection_of: BFO:0000050 UBERON:0001017 ! part of central nervous system relationship: BFO:0000050 UBERON:0001017 ! part of central nervous system +[Term] +id: UBERON:0036343 +name: wall of gallbladder +xref: FMA:14657 +is_a: UBERON:0003697 ! abdominal wall +is_a: UBERON:0004119 ! endoderm-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0002110 ! part of gallbladder +relationship: BFO:0000050 UBERON:0002110 ! part of gallbladder + [Term] id: UBERON:0036351 name: wall of brachiocephalic artery +xref: FMA:15089 is_a: UBERON:0000415 ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery @@ -44698,14 +69334,27 @@ relationship: BFO:0000050 UBERON:0001529 ! part of brachiocephalic artery [Term] id: UBERON:0036352 name: wall of subclavian artery +xref: FMA:15090 is_a: UBERON:0000415 ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001533 ! part of subclavian artery relationship: BFO:0000050 UBERON:0001533 ! part of subclavian artery +[Term] +id: UBERON:0036362 +name: wall of anal canal +xref: FMA:15704 +is_a: UBERON:0001169 ! wall of large intestine +is_a: UBERON:0004121 ! ectoderm-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0000159 ! part of anal canal +intersection_of: BFO:0000050 UBERON:0001007 ! part of digestive system +relationship: BFO:0000050 UBERON:0000159 ! part of anal canal + [Term] id: UBERON:0036422 name: wall of pulmonary artery +xref: FMA:18211 is_a: UBERON:0000415 ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0002012 ! part of pulmonary artery @@ -44714,6 +69363,7 @@ relationship: BFO:0000050 UBERON:0002012 ! part of pulmonary artery [Term] id: UBERON:0036553 name: wall of synovial tendon sheath +xref: FMA:231590 is_a: UBERON:0000042 ! serous membrane is_a: UBERON:0000060 ! anatomical wall intersection_of: UBERON:0000060 ! anatomical wall @@ -44723,15 +69373,28 @@ relationship: BFO:0000050 UBERON:0000304 ! part of tendon sheath [Term] id: UBERON:0036925 name: wall of eyeball +xref: FMA:58098 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004121 ! ectoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye relationship: BFO:0000050 UBERON:0010230 ! part of eyeball of camera-type eye +[Term] +id: UBERON:0037089 +name: wall of orbit +xref: FMA:63144 +is_a: UBERON:0000060 ! anatomical wall +is_a: UBERON:0000075 ! subdivision of skeletal system +is_a: UBERON:0010313 ! neural crest-derived structure +intersection_of: UBERON:0000060 ! anatomical wall +intersection_of: BFO:0000050 UBERON:0001697 ! part of orbit of skull +relationship: BFO:0000050 UBERON:0001697 ! part of orbit of skull + [Term] id: UBERON:0037094 name: wall of common carotid artery +xref: FMA:66284 is_a: UBERON:0000415 ! artery wall intersection_of: UBERON:0000060 ! anatomical wall intersection_of: BFO:0000050 UBERON:0001530 ! part of common carotid artery plus branches @@ -44740,6 +69403,8 @@ relationship: BFO:0000050 UBERON:0001530 ! part of common carotid artery plus br [Term] id: UBERON:0037144 name: wall of heart +def: "Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees." [FMA:7274] +xref: FMA:7274 is_a: UBERON:0000060 ! anatomical wall is_a: UBERON:0004120 ! mesoderm-derived structure intersection_of: UBERON:0000060 ! anatomical wall @@ -44748,9 +69413,43 @@ relationship: BFO:0000050 UBERON:0000948 ! part of heart relationship: RO:0002371 UBERON:0002406 ! pericardial sac relationship: RO:0002371 UBERON:0004292 ! cardiac skeleton +[Term] +id: UBERON:0039222 +name: cystic artery +def: "An artery that supplies oxygenated blood to the cystic duct." [http://orcid.org/0000-0002-6601-2165, https://en.wikipedia.org/wiki/Cystic_artery] +xref: FMA:14835 +is_a: UBERON:0001637 ! artery +is_a: UBERON:0015796 ! liver blood vessel +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0001152 ! cystic duct +relationship: BFO:0000050 UBERON:0015482 ! part of right hepatic artery +relationship: RO:0002178 UBERON:0001152 ! cystic duct + +[Term] +id: UBERON:0039228 +name: sigmoid vein +xref: FMA:15395 +is_a: UBERON:0001638 ! vein +intersection_of: UBERON:0001638 ! vein +intersection_of: RO:0002179 UBERON:0001159 ! sigmoid colon +relationship: RO:0002179 UBERON:0001159 ! sigmoid colon +relationship: RO:0002376 UBERON:0001215 ! inferior mesenteric vein + +[Term] +id: UBERON:0039261 +name: pancreatic artery +xref: FMA:70471 +is_a: UBERON:0001637 ! artery +intersection_of: UBERON:0001637 ! artery +intersection_of: RO:0002178 UBERON:0001264 ! pancreas +relationship: RO:0002178 UBERON:0001264 ! pancreas +relationship: RO:0002252 UBERON:0001194 ! splenic artery + [Term] id: UBERON:0039856 name: right ovarian vein +def: "Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament." [FMA:14342] +xref: FMA:14342 is_a: UBERON:0001145 ! ovarian vein intersection_of: UBERON:0001145 ! ovarian vein intersection_of: RO:0002179 UBERON:0002118 ! right ovary @@ -44760,6 +69459,8 @@ relationship: RO:0002376 UBERON:0001072 ! inferior vena cava [Term] id: UBERON:0039857 name: left ovarian vein +def: "Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament." [FMA:14347] +xref: FMA:14347 is_a: UBERON:0001145 ! ovarian vein intersection_of: UBERON:0001145 ! ovarian vein intersection_of: RO:0002179 UBERON:0002119 ! left ovary @@ -44768,22 +69469,47 @@ relationship: RO:0002179 UBERON:0002119 ! left ovary [Term] id: UBERON:1000021 name: skin of face +def: "A zone of skin that is part of the face." [https://github.com/obophenotype/uberon/issues/34, UBERON:EJS] +xref: EMAPA:36657 +xref: FMA:24758 +xref: NCIT:C33561 +xref: SCTID:361703006 is_a: UBERON:0001084 ! skin of head intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001456 ! part of face relationship: BFO:0000050 UBERON:0001456 ! part of face +[Term] +id: UBERON:1000024 +name: parenchyma of spleen +def: "A parenchyma that is part of a spleen." [OBOL:automatic] +xref: FMA:16029 +is_a: UBERON:0000353 ! parenchyma +is_a: UBERON:0004120 ! mesoderm-derived structure +intersection_of: UBERON:0000353 ! parenchyma +intersection_of: BFO:0000050 UBERON:0002106 ! part of spleen +relationship: BFO:0000050 UBERON:0002106 ! part of spleen + [Term] id: UBERON:1100000 name: digestive tract junction +def: "An anatomical junction between two parts of the digestive tract." [https://orcid.org/0000-0002-7073-9172] is_a: UBERON:0007651 ! anatomical junction intersection_of: UBERON:0007651 ! anatomical junction intersection_of: RO:0002176 UBERON:0004921 ! subdivision of digestive tract relationship: RO:0002176 UBERON:0004921 ! subdivision of digestive tract +[Term] +id: UBERON:2001073 +name: axial vasculature +xref: ZFA:0001073 +is_a: UBERON:0002049 ! vasculature + [Term] id: UBERON:2001457 name: postcranial axial cartilage +def: "Cartilage which is part of the axial skeleton." [ZFIN:curator] +xref: ZFA:0001457 is_a: UBERON:0007844 ! cartilage element intersection_of: UBERON:0007844 ! cartilage element intersection_of: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton @@ -44792,17 +69518,27 @@ relationship: BFO:0000050 UBERON:0002090 ! part of postcranial axial skeleton [Term] id: UBERON:2005260 name: fenestrated capillary +def: "Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse." [Wikipedia:Capillary#Types, Wikipedia:Fenestra_(histology)] +xref: FMA:63196 +xref: NCIT:C32595 +xref: TAO:0005260 +xref: Wikipedia:Capillary#Types +xref: ZFA:0005260 is_a: UBERON:0001982 ! capillary is_a: UBERON:0004638 ! blood vessel endothelium [Term] id: UBERON:2007013 name: preplacodal ectoderm +def: "Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes." [ZFIN:curator] +xref: ZFA:0007013 is_a: UBERON:0005497 ! non-neural ectoderm [Term] id: UBERON:3000961 name: external integument structure +def: "Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument." [AAO:EJS] +comment: Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305 is_a: UBERON:0003102 ! surface structure intersection_of: UBERON:0003102 ! surface structure intersection_of: BFO:0000050 UBERON:0002199 ! part of integument @@ -44811,6 +69547,7 @@ relationship: BFO:0000050 UBERON:0002199 ! part of integument [Term] id: UBERON:3000972 name: head external integument structure +def: "Dermal, epidermal, glandular and pigment structures of the external head integument." [AAO:EJS] is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:3000961 ! external integument structure intersection_of: BFO:0000050 UBERON:0000033 ! part of head @@ -44819,14 +69556,25 @@ relationship: BFO:0000050 UBERON:0000033 ! part of head [Term] id: UBERON:3000977 name: body external integument structure +def: "Dermal, epidermal, glandular and pigment structures of the body integument." [AAO:EJS] is_a: UBERON:3000961 ! external integument structure intersection_of: UBERON:3000961 ! external integument structure intersection_of: BFO:0000050 UBERON:0002100 ! part of trunk relationship: BFO:0000050 UBERON:0002100 ! part of trunk +[Term] +id: UBERON:3000982 +name: tail external integument structure +def: "Dermal, epidermal, glandular and pigment structures of the tail integument." [AAO:EJS] +is_a: UBERON:3000961 ! external integument structure +intersection_of: UBERON:3000961 ! external integument structure +intersection_of: BFO:0000050 UBERON:0007812 ! part of post-anal tail +relationship: BFO:0000050 UBERON:0007812 ! part of post-anal tail + [Term] id: UBERON:3010200 name: vasculature of respiratory integument +def: "Blood vessels in respiratory skin." [AAO:EJS] is_a: UBERON:0003504 ! respiratory system blood vessel intersection_of: UBERON:0001981 ! blood vessel intersection_of: BFO:0000050 UBERON:0001004 ! part of respiratory system @@ -44836,6 +69584,7 @@ relationship: BFO:0000050 UBERON:0002199 ! part of integument [Term] id: UBERON:4200230 name: surface of bone +def: "An anatomical surface that is part of a bone." [PHENOSCAPE] is_a: UBERON:0006984 ! anatomical surface intersection_of: UBERON:0006984 ! anatomical surface intersection_of: BFO:0000050 UBERON:0001474 ! part of bone element @@ -44852,6 +69601,7 @@ relationship: BFO:0000050 NCBITaxon:88770 ! part of Panarthropoda [Term] id: UBERON:8000006 name: left side of back +def: "Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane." [https://microbiomedb.org/] is_a: UBERON:0001137 ! dorsum is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001137 ! dorsum @@ -44861,6 +69611,7 @@ relationship: BSPO:0000120 UBERON:0000468 ! multicellular organism [Term] id: UBERON:8000007 name: right side of back +def: "Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane." [https://microbiomedb.org/] is_a: UBERON:0001137 ! dorsum is_a: UBERON:0015212 ! lateral structure intersection_of: UBERON:0001137 ! dorsum @@ -44870,35 +69621,185 @@ relationship: BSPO:0000121 UBERON:0000468 ! multicellular organism [Term] id: UBERON:8000009 name: Purkinje fiber network +def: "A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles." [PMID:26786210] is_a: UBERON:0010131 ! conducting tissue of heart is_a: UBERON:0018649 ! cardiac muscle tissue of ventricle relationship: BFO:0000050 UBERON:0004146 ! part of His-Purkinje system relationship: BFO:0000051 UBERON:0002354 ! has part cardiac Purkinje fiber +[Term] +id: UBERON:8400021 +name: liver serosa +def: "Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact." [https://medical-dictionary.thefreedictionary.com/serosa+of+liver, https://orcid.org/0000-0002-0449-2730] +is_a: UBERON:0000042 ! serous membrane +is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure +intersection_of: UBERON:0000042 ! serous membrane +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + +[Term] +id: UBERON:8400023 +name: liver subserosa +def: "Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson." [FMA:15812, https://medical-dictionary.thefreedictionary.com/subserosa+of+liver, https://orcid.org/0000-0002-0449-2730] +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0012375 ! subserosa +intersection_of: UBERON:0012375 ! subserosa +intersection_of: BFO:0000050 UBERON:0002107 ! part of liver +relationship: BFO:0000050 UBERON:0002107 ! part of liver + +[Term] +id: UBERON:8410001 +name: small intestine venule +def: "Venule of villus of small intestine." [https://orcid.org/0000-0003-4183-8865] +is_a: UBERON:0001979 ! venule +intersection_of: UBERON:0001979 ! venule +intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus +relationship: BFO:0000050 UBERON:0001213 ! part of intestinal villus + +[Term] +id: UBERON:8410004 +name: small intestine arteriole +def: "Arteriole of villus of small intestine." [http://orcid.org/0000-0003-4183-8865] +is_a: UBERON:0001980 ! arteriole +intersection_of: UBERON:0001980 ! arteriole +intersection_of: BFO:0000050 UBERON:0001213 ! part of intestinal villus +relationship: BFO:0000050 UBERON:0001213 ! part of intestinal villus + +[Term] +id: UBERON:8410008 +name: venule of anorectum +def: "A venule that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: UBERON:0001979 ! venule +intersection_of: UBERON:0001979 ! venule +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: UBERON:8410009 +name: arteriole of anorectum +def: "An arteriole that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: UBERON:0001980 ! arteriole +intersection_of: UBERON:0001980 ! arteriole +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: UBERON:8410015 +name: arteriole of colon +def: "An arteriole located in the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] +is_a: UBERON:0001980 ! arteriole +intersection_of: UBERON:0001980 ! arteriole +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:8410024 +name: intestinal junction +def: "An anatomical junction between two parts of the intestine." [https://orcid.org/0000-0002-7073-9172] +is_a: UBERON:1100000 ! digestive tract junction +intersection_of: UBERON:0007651 ! anatomical junction +intersection_of: BFO:0000050 UBERON:0000160 ! part of intestine +intersection_of: RO:0002176 UBERON:0004921 ! subdivision of digestive tract +relationship: BFO:0000050 UBERON:0000160 ! part of intestine + +[Term] +id: UBERON:8410043 +name: bronchus submucosal gland +def: "A submucosal gland located in a bronchus." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] +is_a: UBERON:8410077 ! airway submucosal gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: BFO:0000050 UBERON:0002185 ! part of bronchus +relationship: BFO:0000050 UBERON:0002185 ! part of bronchus + +[Term] +id: UBERON:8410048 +name: venule of colon +def: "A venule located in the colon." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865] +is_a: UBERON:0001979 ! venule +intersection_of: UBERON:0001979 ! venule +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:8410050 +name: anorectum +def: "A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus." [DOI:10.1007/978-3-319-26938-2_8, DOI:10.1148/rg.2015150037, http://orcid.org/0000-0002-6826-8770, http://orcid.org/0000-0003-3440-1876, PMID:29742860] +is_a: UBERON:0004921 ! subdivision of digestive tract +intersection_of: UBERON:0004921 ! subdivision of digestive tract +intersection_of: BFO:0000051 UBERON:0000159 ! has part anal canal +intersection_of: BFO:0000051 UBERON:0001052 ! has part rectum +intersection_of: BFO:0000051 UBERON:0001245 ! has part anus +relationship: BFO:0000050 UBERON:0000059 ! part of large intestine +relationship: BFO:0000051 UBERON:0000159 ! has part anal canal +relationship: BFO:0000051 UBERON:0001052 ! has part rectum +relationship: BFO:0000051 UBERON:0001245 ! has part anus + +[Term] +id: UBERON:8410056 +name: capillary of anorectum +def: "A capillary that is part of the anorectum." [http://orcid.org/0000-0003-3440-1876] +is_a: UBERON:0001982 ! capillary +intersection_of: UBERON:0001982 ! capillary +intersection_of: BFO:0000050 UBERON:8410050 ! part of anorectum +relationship: BFO:0000050 UBERON:8410050 ! part of anorectum + +[Term] +id: UBERON:8410057 +name: capillary of colon +def: "A capillary that is part of the colon." [http://orcid.org/0000-0003-3440-1876] +is_a: UBERON:0001982 ! capillary +intersection_of: UBERON:0001982 ! capillary +intersection_of: BFO:0000050 UBERON:0001155 ! part of colon +relationship: BFO:0000050 UBERON:0001155 ! part of colon + +[Term] +id: UBERON:8410068 +name: capillary of small intestine +def: "A capillary that is part of a small intestine." [http://orcid.org/0000-0003-3440-1876] +is_a: UBERON:0001982 ! capillary +intersection_of: UBERON:0001982 ! capillary +intersection_of: BFO:0000050 UBERON:0002108 ! part of small intestine +relationship: BFO:0000050 UBERON:0002108 ! part of small intestine + +[Term] +id: UBERON:8410077 +name: airway submucosal gland +def: "A submucosal gland found in a respiratory tract." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865] +xref: EFO:0010666 +is_a: UBERON:0004119 ! endoderm-derived structure +is_a: UBERON:0011148 ! submucosal gland +is_a: UBERON:0036225 ! respiratory system gland +intersection_of: UBERON:0011148 ! submucosal gland +intersection_of: BFO:0000050 UBERON:0000065 ! part of respiratory tract +relationship: BFO:0000050 UBERON:0000065 ! part of respiratory tract + [Term] id: UBERON:8410081 name: blood microvessel +def: "Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins." [http://orcid.org/0000-0002-7073-9172, Wikipedia:Microcirculation] is_a: UBERON:0001981 ! blood vessel is_a: UBERON:0010523 ! microcirculatory vessel [Term] id: UBERON:8440015 name: noradrenergic cell groups +def: "Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin)." [WikipediaVersioned:Noradrenergic_cell_groups&oldid=965992184] is_a: UBERON:0002616 ! regional part of brain relationship: RO:0002473 CL:0000459 ! noradrenergic cell [Term] id: UBERON:8450002 name: excretory system +def: "An anatomical system that eliminates waste products that arise as a result of metabolic activity." [GO:0007588] is_a: UBERON:0000467 ! anatomical system intersection_of: UBERON:0000467 ! anatomical system intersection_of: RO:0002215 GO:0046903 ! capable of secretion relationship: RO:0002215 GO:0046903 ! capable of secretion -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:8480001 name: capillary of brain +def: "A capillary that is part of the brain." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0001982 ! capillary is_a: UBERON:0003499 ! brain blood vessel intersection_of: UBERON:0001982 ! capillary @@ -44907,6 +69808,7 @@ intersection_of: BFO:0000050 UBERON:0000955 ! part of brain [Term] id: UBERON:8480002 name: thoracic aorta smooth muscle tissue +def: "A portion of smooth muscle tissue that is part of the thoracic aorta." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0004178 ! aorta smooth muscle tissue intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: BFO:0000050 UBERON:0001515 ! part of thoracic aorta @@ -44915,6 +69817,7 @@ relationship: BFO:0000050 UBERON:0001515 ! part of thoracic aorta [Term] id: UBERON:8480025 name: skin of clavicle region +def: "A zone of skin that is above the clavicle zone in the pectoral girdle region." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0000014 ! zone of skin intersection_of: UBERON:0000014 ! zone of skin intersection_of: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region @@ -44923,6 +69826,7 @@ relationship: BFO:0000050 UBERON:0001421 ! part of pectoral girdle region [Term] id: UBERON:8480029 name: skin of external genitalia +def: "A zone of skin that is part of the external genitalia." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0000014 ! zone of skin is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000014 ! zone of skin @@ -44932,6 +69836,7 @@ relationship: BFO:0000050 UBERON:0004176 ! part of external genitalia [Term] id: UBERON:8480074 name: skin of gonad +def: "A zone of skin part of some gonad." [https://orcid.org/0000-0002-0819-0473] is_a: UBERON:0000014 ! zone of skin is_a: UBERON:0005156 ! reproductive structure intersection_of: UBERON:0000014 ! zone of skin @@ -44941,27 +69846,41 @@ relationship: BFO:0000050 UBERON:0000991 ! part of gonad [Term] id: UBERON:8600004 name: visceral muscle tissue +def: "A muscle tissue that is associated with soft internal organs (viscera)." [BTO:0002780, CLAO:0001295] +comment: It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated. {xref="https://en.wikipedia.org/wiki/Smooth_muscle", xref="FBbt:00005070", comment="PMID:8720463"} is_a: UBERON:0002385 ! muscle tissue relationship: RO:0002473 CL:0008007 ! visceral muscle cell [Term] id: UBERON:8600006 name: visceral striated muscle tissue +def: "A striated muscle tissue that is associated with soft internal organs (viscera)." [https://pressbooks.pub/rbtallitsch/chapter/chapter-6-muscle-tissue/, PMID:8720463] is_a: UBERON:0002036 ! striated muscle tissue is_a: UBERON:8600004 ! visceral muscle tissue +[Term] +id: UBERON:8600012 +name: submucosal gland acinus +def: "A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium." [PMID:17394068, PMID:17707699, PMID:25648514, PMID:30864819] +is_a: UBERON:0014717 ! mucous acinus +intersection_of: UBERON:0009842 ! glandular acinus +intersection_of: BFO:0000050 UBERON:0011148 ! part of submucosal gland +relationship: BFO:0000050 UBERON:0011148 ! part of submucosal gland + [Term] id: UBERON:8600017 name: bronchopulmonary segment +def: "A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface." [doi:10.1016/j.mpaic.2008.09.022, FMA:7312, PMID:18271171, PMID:33620799] +comment: A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung. {xref="doi:10.1016/j.mpaic.2008.09.022", xref="PMID:18271171"} is_a: UBERON:0000063 ! organ subunit is_a: UBERON:0004119 ! endoderm-derived structure relationship: BFO:0000050 UBERON:0000101 ! part of lobe of lung relationship: RO:0002433 UBERON:0000101 ! lobe of lung -property_value: RO:0002175 NCBITaxon:9606 [Term] id: UBERON:8600024 name: pulmonary venule +def: "A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa." [PMID:22283705, PMID:30247823] is_a: UBERON:0003494 ! respiratory system venule is_a: UBERON:0003512 ! lung blood vessel is_a: UBERON:0005194 ! thoracic vein @@ -44971,28 +69890,103 @@ relationship: BFO:0000050 UBERON:0013127 ! part of pulmonary venous system relationship: RO:0002170 UBERON:0002016 ! pulmonary vein relationship: RO:0002179 UBERON:0016405 ! pulmonary capillary +[Term] +id: http://identifiers.org/ensembl/ENSG00000038945 +name: MSR1 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000050730 +name: TNIP3 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000100292 +name: HMOX1 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000131471 +name: AOC3 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000137804 +name: NUSAP1 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000139329 +name: LUM +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000163735 +name: CXCL5 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000164120 +name: HPGD +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000166803 +name: PCLAF +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000168079 +name: SCARA5 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000170323 +name: FABP4 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000171848 +name: RRM2 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000174807 +name: CD248 +is_a: SO:0000704 ! gene + +[Term] +id: http://identifiers.org/ensembl/ENSG00000175063 +name: UBE2C +is_a: SO:0000704 ! gene + [Typedef] id: BFO:0000050 name: part of +xref: BFO:0000050 is_transitive: true inverse_of: BFO:0000051 ! has part [Typedef] id: BFO:0000051 name: has part +xref: BFO:0000051 is_transitive: true [Typedef] id: BFO:0000062 name: preceded by +xref: BFO:0000062 [Typedef] id: BFO:0000063 name: precedes +xref: BFO:0000063 [Typedef] id: BFO:0000066 name: occurs in +xref: BFO:0000066 transitive_over: BFO:0000050 ! part of [Typedef] @@ -45007,36 +70001,44 @@ name: lacks_plasma_membrane_part id: GOREL:0002003 name: results in distribution of name: results_in_distribution_of +xref: GOREL:0002003 [Typedef] id: GOREL:0002004 name: results in fission of name: results_in_fission_of +xref: GOREL:0002004 is_a: RO:0000057 ! has participant [Typedef] id: RO:0000053 name: bearer of +xref: RO:0000053 [Typedef] id: RO:0000056 name: participates in +xref: RO:0000056 [Typedef] id: RO:0000057 name: has participant +xref: RO:0000057 [Typedef] id: RO:0002007 name: bounding layer of +xref: RO:0002007 [Typedef] id: RO:0002087 name: immediately preceded by +xref: RO:0002087 [Typedef] id: RO:0002131 name: overlaps +xref: RO:0002131 [Typedef] id: RO:0002162 @@ -45045,157 +70047,203 @@ holds_over_chain: extends_fibers_into RO:0002162 [Typedef] id: RO:0002180 name: has component +xref: RO:0002180 [Typedef] id: RO:0002211 name: regulates +xref: RO:0002211 is_transitive: true [Typedef] id: RO:0002212 name: negatively regulates +xref: RO:0002212 is_a: RO:0002211 ! regulates [Typedef] id: RO:0002213 name: positively regulates +xref: RO:0002213 holds_over_chain: RO:0002212 RO:0002212 is_a: RO:0002211 ! regulates [Typedef] id: RO:0002215 name: capable of +xref: RO:0002215 [Typedef] id: RO:0002216 name: capable of part of +xref: RO:0002216 [Typedef] id: RO:0002220 name: adjacent to +xref: RO:0002220 [Typedef] id: RO:0002224 name: starts with +xref: RO:0002224 [Typedef] id: RO:0002230 name: ends with +xref: RO:0002230 [Typedef] id: RO:0002231 name: has start location +xref: RO:0002231 [Typedef] id: RO:0002232 name: has end location +xref: RO:0002232 [Typedef] id: RO:0002295 name: results in developmental progression of +xref: RO:0002295 [Typedef] id: RO:0002296 name: results in development of +xref: RO:0002296 [Typedef] id: RO:0002297 name: results in formation of +xref: RO:0002297 [Typedef] id: RO:0002298 name: results in morphogenesis of +xref: RO:0002298 [Typedef] id: RO:0002299 name: results in maturation of +xref: RO:0002299 [Typedef] id: RO:0002315 name: results in acquisition of features of +xref: RO:0002315 + +[Typedef] +id: RO:0002332 +name: regulates levels of +xref: RO:0002332 [Typedef] id: RO:0002338 name: has target start location +xref: RO:0002338 [Typedef] id: RO:0002339 name: has target end location +xref: RO:0002339 [Typedef] id: RO:0002341 name: results in transport along +xref: RO:0002341 [Typedef] id: RO:0002342 name: results in transport across +xref: RO:0002342 [Typedef] id: RO:0002343 name: results in growth of +xref: RO:0002343 [Typedef] id: RO:0002344 name: results in transport to from or in +xref: RO:0002344 [Typedef] id: RO:0002353 name: output of +xref: RO:0002353 [Typedef] id: RO:0002565 name: results in movement of +xref: RO:0002565 [Typedef] id: RO:0002588 name: results in assembly of +xref: RO:0002588 [Typedef] id: RO:0002590 name: results in disassembly of +xref: RO:0002590 [Typedef] id: RO:0002592 name: results in organization of +xref: RO:0002592 is_a: RO:0000057 ! has participant [Typedef] id: RO:0002608 name: process has causal agent +xref: RO:0002608 [Typedef] id: RO:0003000 name: produces +xref: RO:0003000 [Typedef] id: RO:0003001 name: produced by +xref: RO:0003001 [Typedef] id: RO:0004007 name: has primary input or output +xref: RO:0004007 [Typedef] id: RO:0004008 name: has primary output +xref: RO:0004008 [Typedef] id: RO:0004009 name: has primary input +xref: RO:0004009 [Typedef] id: RO:0012003 name: acts on population of +xref: RO:0012003 is_a: RO:0000057 ! has participant [Typedef] id: RO:0012008 name: results in fusion of +xref: RO:0012008 is_a: RO:0002592 ! results in organization of +[Typedef] +id: RO:0015004 +name: has characterizing marker set + [Typedef] id: anteriorly_connected_to name: anteriorly connected to +def: "x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000099 is_a: RO:0002170 is_a: transitively_anteriorly_connected_to ! transitively anteriorly connected to @@ -45219,6 +70267,7 @@ is_transitive: true [Typedef] id: distally_connected_to name: distally connected to +def: "x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000100 is_a: RO:0002170 is_a: transitively_distally_connected_to ! transitively distally connected to @@ -45227,6 +70276,7 @@ inverse_of: proximally_connected_to ! proximally connected to [Typedef] id: extends_fibers_into name: extends_fibers_into +def: "X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y" [https://orcid.org/0000-0002-7073-9172] is_symmetric: true is_a: RO:0002170 @@ -45234,10 +70284,23 @@ is_a: RO:0002170 id: filtered_through name: filtered through def: "Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity." [] +comment: Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed + +[Typedef] +id: indirectly_supplies +name: indirectly_supplies +def: "a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s." [] +is_transitive: true + +[Typedef] +id: layer_part_of +name: layer part of +is_a: BFO:0000050 ! part of [Typedef] id: posteriorly_connected_to name: posteriorly connected to +def: "x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000096 is_a: RO:0002170 @@ -45248,6 +70311,7 @@ name: protects [Typedef] id: proximally_connected_to name: proximally connected to +def: "x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] is_a: BSPO:0000097 is_a: RO:0002170 is_a: transitively_proximally_connected_to ! transitively proximally connected to @@ -45260,6 +70324,7 @@ def: "c site_of p if c is the bearer of a disposition that is realized by a proc [Typedef] id: subdivision_of name: subdivision of +comment: placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B [Typedef] id: transitively_anteriorly_connected_to diff --git a/clm.owl b/clm.owl index 8e9d7a2..a17e373 100644 --- a/clm.owl +++ b/clm.owl @@ -8,13 +8,14 @@ xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" - xmlns:dcterms="http://purl.org/dc/terms/"> + xmlns:dcterms="http://purl.org/dc/terms/" + xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + None Cell Markers Ontology - 2024-07-26 + 2024-07-29 @@ -42,12 +43,6 @@ - - - - - - @@ -102,6 +97,20 @@ + + + + database_cross_reference + + + + + + + + + + + BFO:0000062 preceded by @@ -143,6 +155,7 @@ + BFO:0000063 precedes @@ -155,6 +168,7 @@ + BFO:0000066 occurs in @@ -256,6 +270,24 @@ + + + + + + + + + + + + + + + + + + @@ -275,6 +307,7 @@ + GOREL:0002003 results in distribution of results_in_distribution_of @@ -285,6 +318,7 @@ + GOREL:0002004 results in fission of results_in_fission_of @@ -294,6 +328,7 @@ + RO:0000053 bearer of @@ -302,6 +337,7 @@ + RO:0000056 participates in @@ -310,6 +346,7 @@ + RO:0000057 has participant @@ -348,6 +385,7 @@ + RO:0002007 bounding layer of @@ -362,6 +400,7 @@ + RO:0002087 immediately preceded by @@ -388,6 +427,7 @@ + RO:0002131 overlaps @@ -449,6 +489,7 @@ + RO:0002180 has component @@ -470,6 +511,7 @@ + RO:0002211 regulates @@ -479,6 +521,7 @@ + RO:0002212 negatively regulates @@ -492,6 +535,7 @@ + RO:0002213 positively regulates @@ -500,6 +544,7 @@ + RO:0002215 capable of @@ -508,6 +553,7 @@ + RO:0002216 capable of part of @@ -522,6 +568,7 @@ + RO:0002220 adjacent to @@ -542,11 +589,18 @@ + RO:0002224 starts with + + + + + + @@ -556,6 +610,7 @@ + RO:0002230 ends with @@ -564,6 +619,7 @@ + RO:0002231 has start location @@ -572,6 +628,7 @@ + RO:0002232 has end location @@ -610,6 +667,7 @@ + RO:0002295 results in developmental progression of @@ -618,6 +676,7 @@ + RO:0002296 results in development of @@ -626,6 +685,7 @@ + RO:0002297 results in formation of @@ -634,6 +694,7 @@ + RO:0002298 results in morphogenesis of @@ -642,6 +703,7 @@ + RO:0002299 results in maturation of @@ -650,6 +712,7 @@ + RO:0002315 results in acquisition of features of @@ -661,9 +724,19 @@ + + + + RO:0002332 + regulates levels of + + + + + RO:0002338 has target start location @@ -672,6 +745,7 @@ + RO:0002339 has target end location @@ -680,6 +754,7 @@ + RO:0002341 results in transport along @@ -688,6 +763,7 @@ + RO:0002342 results in transport across @@ -696,6 +772,7 @@ + RO:0002343 results in growth of @@ -704,6 +781,7 @@ + RO:0002344 results in transport to from or in @@ -718,6 +796,7 @@ + RO:0002353 output of @@ -729,6 +808,12 @@ + + + + + + @@ -834,11 +919,18 @@ + RO:0002565 results in movement of + + + + + + @@ -860,6 +952,7 @@ + RO:0002588 results in assembly of @@ -868,6 +961,7 @@ + RO:0002590 results in disassembly of @@ -877,6 +971,7 @@ + RO:0002592 results in organization of @@ -885,6 +980,7 @@ + RO:0002608 process has causal agent @@ -893,6 +989,7 @@ + RO:0003000 produces @@ -901,6 +998,7 @@ + RO:0003001 produced by @@ -909,6 +1007,7 @@ + RO:0004007 has primary input or output @@ -917,6 +1016,7 @@ + RO:0004008 has primary output @@ -925,6 +1025,7 @@ + RO:0004009 has primary input @@ -934,6 +1035,7 @@ + RO:0012003 acts on population of @@ -943,11 +1045,20 @@ + RO:0012008 results in fusion of + + + + has characterizing marker set + + + + @@ -960,14 +1071,27 @@ + + + + + + + x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. anteriorly connected to + + + + x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. + http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -1006,8 +1130,15 @@ + x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y. distally connected to + + + + x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y. + http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -1016,8 +1147,15 @@ + X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y extends_fibers_into + + + + X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y + https://orcid.org/0000-0002-7073-9172 + @@ -1025,18 +1163,45 @@ Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity. + Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed filtered through + + + + + a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s. + indirectly_supplies + + + + + + + + + layer part of + + + + + x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. posteriorly connected to + + + + x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. + http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -1054,8 +1219,15 @@ + x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y. proximally connected to + + + + x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y. + http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern + @@ -1071,6 +1243,7 @@ + placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B subdivision of @@ -1114,87 +1287,129 @@ - + - + + + MSR1 + - + - + + + TNIP3 + - + - + + + HMOX1 + - + - + + + AOC3 + - + - + + + NUSAP1 + - + - + + + LUM + - + - + + + CXCL5 + - + - + + + HPGD + - + - + + + PCLAF + - + - + + + SCARA5 + - + - + + + FABP4 + - + - + + + RRM2 + - + - + + + CD248 + - + - + + + UBE2C + @@ -1252,18 +1467,36 @@ + + + + + + + + + + + + + + + + + + @@ -1276,12 +1509,24 @@ + + + + + + + + + + + + @@ -1320,18 +1565,36 @@ + + + + + + + + + + + + + + + + + + @@ -1386,18 +1649,36 @@ + + + + + + + + + + + + + + + + + + @@ -1406,6 +1687,36 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -1442,6 +1753,12 @@ + + + + + + @@ -1456,9 +1773,7 @@ - - root node - + @@ -1472,11 +1787,40 @@ + + + + + + + A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. + CALOHA:TS-2035 + FMA:68646 + GO:0005623 + KUPO:0000002 + MESH:D002477 + VHOG:0001533 + WBbt:0004017 + XAO:0003012 + A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26. + The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). cell + + + + A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. + CARO:mah + + + + + A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26. + https://doi.org/10.5281/zenodo.11165918 + @@ -1501,8 +1845,15 @@ + Any fibroblast that is derived from the neural crest. neural crest derived fibroblast + + + + Any fibroblast that is derived from the neural crest. + https://orcid.org/0000-0001-5208-3432 + @@ -1523,8 +1874,15 @@ + Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception. neuronal receptor cell + + + + Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception. + FBC:Autogenerated + @@ -1532,8 +1890,15 @@ + A cell found in the embryo before the formation of all the gem layers is complete. early embryonic cell (metazoa) + + + + A cell found in the embryo before the formation of all the gem layers is complete. + GOC:tfm + @@ -1541,8 +1906,16 @@ + Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination. migratory cranial neural crest cell + + + + Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination. + ZFA:0007091 + https://orcid.org/0000-0001-5208-3432 + @@ -1550,8 +1923,16 @@ + Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination. migratory trunk neural crest cell + + + + Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination. + ZFA:0007095 + https://orcid.org/0000-0001-5208-3432 + @@ -1571,8 +1952,15 @@ + A stem cell that is the precursor of gametes. germ line stem cell + + + + A stem cell that is the precursor of gametes. + doi:10.1016/j.stem.2012.05.016 + @@ -1597,8 +1985,20 @@ + Female germ cell is a germ cell that supports female gamete production. + MA:0000388 + VHOG:0001530 + ncithesaurus:Egg female germ cell + + + + Female germ cell is a germ cell that supports female gamete production. + GOC:tfm + PMID:11023867 + PMID:20454446 + @@ -1618,8 +2018,15 @@ + A stem cell that is the precursor of female gametes. female germ line stem cell + + + + A stem cell that is the precursor of female gametes. + doi:10.1016/j.stem.2012.05.016 + @@ -1641,8 +2048,21 @@ + A female germ cell that has entered meiosis. + BTO:0000964 + CALOHA:TS-0711 + FMA:18644 + MESH:D009865 + WBbt:0006797 oocyte + + + + A female germ cell that has entered meiosis. + GOC:tfm + ISBN:0721662544 + @@ -1674,8 +2094,17 @@ + An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes. + FMA:83673 oogonial cell + + + + An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes. + GOC:tfm + ISBN:0721662544 + @@ -1696,8 +2125,21 @@ + A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization. + BTO:0000369 + BTO:0003801 + CALOHA:TS-2191 + FMA:67343 + MESH:D010063 egg cell + + + + A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization. + GOC:tfm + ISBN:0721662544 + @@ -1722,8 +2164,15 @@ + A smooth muscle cell derived from the neural crest. smooth muscle cell neural crest derived + + + + A smooth muscle cell derived from the neural crest. + https://orcid.org/0000-0001-5208-3432 + @@ -1755,8 +2204,15 @@ + Any neuron that develops from some migratory neural crest cell. neural crest derived neuron + + + + Any neuron that develops from some migratory neural crest cell. + FBC:Autogenerated + @@ -1771,8 +2227,18 @@ + A cell that will develop into a neuron often after a migration phase. + BTO:0000930 + FMA:70563 neuroblast (sensu Vertebrata) + + + + A cell that will develop into a neuron often after a migration phase. + GOC:NV + http://en.wikipedia.org/wiki/Neuroblast + @@ -1803,9 +2269,19 @@ - + A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + CALOHA:TS-2086 + FMA:63368 + This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’. stem cell + + + + A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + GOC:tfm + MESH:D013234 + @@ -1834,8 +2310,16 @@ + A stem cell that self-renews as well as give rise to a single mature cell type. + FMA:70569 single fate stem cell + + + + A stem cell that self-renews as well as give rise to a single mature cell type. + GOC:tfm + @@ -1992,9 +2476,25 @@ - + A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. + BTO:0000725 + CALOHA:TS-0448 + FMA:86475 + MESH:D006412 + VHOG:0001485 + Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. hematopoietic stem cell + + + + A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. + GOC:add + GOC:dsd + GOC:tfm + PMID:19022770 + http://en.wikipedia.org/wiki/Hematopoietic_stem_cell + @@ -2009,8 +2509,17 @@ + A progenitor cell committed to the erythroid lineage. + BTO:0004911 erythroid progenitor cell + + + + A progenitor cell committed to the erythroid lineage. + GOC:add + ISBN:0721601464 + @@ -2024,8 +2533,17 @@ + A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. + Originally this term had some plant germ line cell children. germ line cell + + + + A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. + GOC:tfm + ISBN:0721662544 + @@ -2091,8 +2609,21 @@ + A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus. + CALOHA:TS-1195 + FMA:83553 + Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. monoblast + + + + A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus. + GOC:add + PMID:1104740 + http://en.wikipedia.org/wiki/Monoblast + http://www.copewithcytokines.de + @@ -2121,8 +2652,16 @@ + A stem cell that can give rise to multiple lineages of cells. + FMA:84789 multi fate stem cell + + + + A stem cell that can give rise to multiple lineages of cells. + GOC:add + @@ -2133,9 +2672,19 @@ - + A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. + BTO:0004730 + This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). common myeloid progenitor + + + + A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. + GOC:add + ISBN:0878932437 + MESH:D023461 + @@ -2174,9 +2723,21 @@ - + A progenitor cell committed to the megakaryocyte and erythroid lineages. + MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. megakaryocyte-erythroid progenitor cell + + + + A progenitor cell committed to the megakaryocyte and erythroid lineages. + GOC:add + GOC:dsd + GOC:tfm + MESH:D055015 + PMID:16647566 + http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell + @@ -2202,9 +2763,20 @@ - + A oligopotent progenitor cell committed to the lymphoid lineage. + CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. common lymphoid progenitor + + + + A oligopotent progenitor cell committed to the lymphoid lineage. + GOC:add + GOC:dsd + GOC:tfm + PMID:10407577 + PMID:16551251 + @@ -2212,8 +2784,18 @@ + A stem cell from which all cells of the body can form. + FMA:84790 + MESH:D039901 totipotent stem cell + + + + A stem cell from which all cells of the body can form. + GOC:add + GOC:tfm + @@ -2221,8 +2803,18 @@ + A precursor cell with a limited number of potential fates. + BTO:0000125 + FMA:84782 + define using PATO mulit-potent or oligopotent? non-terminally differentiated cell + + + + A precursor cell with a limited number of potential fates. + SANBI:mhl + @@ -2230,8 +2822,21 @@ + A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. + BTO:0000222 + CALOHA:TS-0650 + FMA:70335 + VHOG:0001529 myoblast + + + + A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. + GOC:tfm + MESH:D032446 + PMID:21849021 + @@ -2246,9 +2851,23 @@ - + A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. + BTO:0000452 + CALOHA:TS-0362 + FMA:63877 + NCIT:C12482 + VHOG:0001482 + These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. fibroblast + + + + A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. + ISBN:0517223651 + MESH:D005347 + http://en.wikipedia.org/wiki/Fibroblast + @@ -2270,8 +2889,19 @@ + Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell. + BTO:0003607 + FMA:66783 chondroblast + + + + Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell. + GOC:tfm + GO_REF:0000034 + ISBN:0618947256 + @@ -2296,8 +2926,17 @@ + A cell that has a filiform extrusion of the cell surface. + VHOG:0001532 + XAO:0000031 ciliated cell + + + + A cell that has a filiform extrusion of the cell surface. + GOC:tfm + @@ -2312,9 +2951,22 @@ - + A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. + BTO:0000414 + CALOHA:TS-2026 + CARO:0000077 + FMA:66768 + WBbt:0003672 epithelial cell + + + + A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. + FB:ma + GOC:tfm + MESH:D004847 + @@ -2334,8 +2986,16 @@ + An epithelial cell that has a cilia. + FMA:70605 ciliated epithelial cell + + + + An epithelial cell that has a cilia. + GOC:tfm + @@ -2360,8 +3020,15 @@ + An epithelial cell that is part of a duct. duct epithelial cell + + + + An epithelial cell that is part of a duct. + https://orcid.org/0000-0001-5208-3432 + @@ -2401,9 +3068,15 @@ - + An endothelial cell that lines the vasculature. blood vessel endothelial cell + + + + An endothelial cell that lines the vasculature. + GOC:tfm + @@ -2411,9 +3084,16 @@ - + A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. columnar/cuboidal epithelial cell + + + + A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. + GO:0002065 + https://orcid.org/0000-0001-5208-3432 + @@ -2421,6 +3101,7 @@ + CALOHA:TS-1249 squamous epithelial cell @@ -2432,9 +3113,17 @@ - + A flattened epithelial cell of mesenchymal origin that lines the serous cavity. + FMA:66773 mesothelial cell + + + + A flattened epithelial cell of mesenchymal origin that lines the serous cavity. + GOC:tfm + ISBN:0721662544 + @@ -2459,8 +3148,15 @@ + A cell which moves among different tissues of the body, via blood, lymph, or other medium. circulating cell + + + + A cell which moves among different tissues of the body, via blood, lymph, or other medium. + GOC:add + @@ -2485,8 +3181,18 @@ + A cell found predominately in the blood. + FMA:62844 + MESH:D001773 blood cell + + + + A cell found predominately in the blood. + GOC:add + GOC:tfm + @@ -2511,8 +3217,50 @@ + An epithelial cell of the lung. + BTO:0004299 epithelial cell of lung + + + + An epithelial cell of the lung. + https://orcid.org/0000-0001-5208-3432 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the pancreas. + BTO:0000028 + epithelial cell of pancreas + + + + + An epithelial cell of the pancreas. + GOC:tfm + @@ -2543,9 +3291,22 @@ - + A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. + BTO:0000782 + CALOHA:TS-1001 + FMA:62870 + MESH:D013601 + VHOG:0001479 T cell + + + + A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. + GOC:add + GOC:tfm + ISBN:0781735149 + @@ -2652,8 +3413,26 @@ + A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. + BTO:0000968 + CALOHA:TS-0721 + FMA:66781 + MESH:D010010 + Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. osteoclast + + + + A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. + GOC:add + GOC:tfm + GO_REF:0000031 + ISBN:0781735149 + PMID:10428500 + PMID:15055519 + PMID:17380158 + @@ -2753,9 +3532,22 @@ - + A leukocyte with abundant granules in the cytoplasm. + BTO:0000539 + BTO:0001026 + CALOHA:TS-0422 + FMA:62854 granulocyte + + + + A leukocyte with abundant granules in the cytoplasm. + GOC:amm + GOC:tfm + MESH:D006098 + http://en.wikipedia.org/wiki/Granulocyte + @@ -2791,8 +3583,19 @@ + A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells. + BTO:0004301 + The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). sensory epithelial cell + + + + A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells. + GOC:tfm + ISBN:0517223651 + ISBN:0721662544 + @@ -2800,9 +3603,19 @@ - + Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. + BTO:0003811 + FMA:67313 + WBbt:0005113 interneuron + + + + Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. + GOC:tfm + MESH:D007395 + @@ -2810,9 +3623,19 @@ - + An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. + BTO:0000312 + FMA:83617 + WBbt:0005409 motor neuron + + + + An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. + MESH:D009046 + PMID:16875686 + @@ -2837,9 +3660,19 @@ - + Any neuron having a sensory function; an afferent neuron conveying sensory impulses. + BTO:0001037 + FMA:84649 + MESH:D011984 + WBbt:0005759 sensory neuron + + + + Any neuron having a sensory function; an afferent neuron conveying sensory impulses. + ISBN:0721662544 + @@ -2864,8 +3697,16 @@ + A neuron whose cell body is within an autonomic ganglion. + FMA:80121 autonomic neuron + + + + A neuron whose cell body is within an autonomic ganglion. + GOC:tfm + @@ -2885,9 +3726,18 @@ - + A vertebrate phagocyte with a single nucleus. + BTO:0001433 mononuclear phagocyte + + + + A vertebrate phagocyte with a single nucleus. + GOC:add + GOC:tfm + ISBN:0781735149 + @@ -2902,9 +3752,23 @@ - + An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm. + BTO:0001176 + CALOHA:TS-0278 + FMA:66772 + From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. endothelial cell + + + + An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm. + GOC:tfm + MESH:D042783 + PMID:21275341 + http://en.wikipedia.org/wiki/Endothelial_cell + https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855 + @@ -2934,9 +3798,19 @@ - + A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. + BTO:0002606 + CALOHA:TS-0415 + FMA:54536 + Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571 glial cell + + + + A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. + MESH:D009457 + @@ -2944,8 +3818,16 @@ + Ectoderm destined to be nervous tissue. neurectodermal cell + + + + Ectoderm destined to be nervous tissue. + GOC:tfm + ISBN:068340007X + @@ -2954,8 +3836,27 @@ + A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. + BTO:0002625 + BTO:0003298 + FMA:70546 + Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. mesenchymal stem cell + + + + A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. + FB:ma + GOC:dsd + PMCID:PMC2613570 + PMID:10102814 + PMID:16923606 + PMID:17986482 + PMID:19960544 + http://en.wikipedia.org/wiki/Mesenchymal_stem_cell + http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells + @@ -2971,9 +3872,18 @@ - + A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides. + BTO:0000443 + CALOHA:TS-0012 + FMA:63880 adipocyte + + + + A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides. + MESH:D017667 + @@ -2994,8 +3904,19 @@ + Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell. + BTO:0000249 + CALOHA:TS-0138 + FMA:66782 chondrocyte + + + + Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell. + GO_REF:0000034 + MESH:D019902 + @@ -3020,8 +3941,17 @@ + A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. + Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. professional antigen presenting cell + + + + A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. + GOC:add + ISBN:0781735149 + @@ -3029,8 +3959,16 @@ + A pigment cell is a cell that contains pigment granules. + VHOG:0001678 pigment cell + + + + A pigment cell is a cell that contains pigment granules. + GOC:tfm + @@ -3054,8 +3992,17 @@ + A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. + CALOHA:TS-2085 + FMA:86494 glandular epithelial cell + + + + A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. + GOC:tfm + @@ -3080,8 +4027,18 @@ + A cell that specializes in controlled release of one or more substances. + BTO:0003659 + FMA:86916 secretory cell + + + + A cell that specializes in controlled release of one or more substances. + GOC:tfm + ISBN:0721662544 + @@ -3106,8 +4063,16 @@ + A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct. + FMA:16014 exocrine cell + + + + A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct. + ISBN:0198547684 + @@ -3116,8 +4081,15 @@ + A cell that secretes glycosaminoglycans. glycosaminoglycan secreting cell + + + + A cell that secretes glycosaminoglycans. + GOC:tfm + @@ -3142,8 +4114,15 @@ + Any secretory cell that is capable of some protein secretion. protein secreting cell + + + + Any secretory cell that is capable of some protein secretion. + FBC:Autogenerated + @@ -3168,8 +4147,16 @@ + A cell that specializes in secretion of surfactant in the alveoli of the lung. surfactant secreting cell + + + + A cell that specializes in secretion of surfactant in the alveoli of the lung. + GOC:tfm + ISBN:0721662544 + @@ -3185,9 +4172,22 @@ - + A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium. + BTO:0004811 + FMA:14119 club cell + + + + A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium. + DOI:10.1183/09031936.00146609 + DOI:10.1378/chest.12-2762 + GOC:tfm + PMID:28128362 + PMID:29874100 + PMID:7905712 + @@ -3247,9 +4247,16 @@ - + A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. + FMA:83809 endocrine cell + + + + A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. + MESH:D055098 + @@ -3258,8 +4265,19 @@ + An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. + BTO:0003865 + FMA:62930 + MESH:D019858 enteroendocrine cell + + + + An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. + GOC:tfm + SANBI:mhl + @@ -3280,9 +4298,29 @@ - + A neuron that is capable of some hormone secretion in response to neuronal signals. + BTO:0002691 + FMA:83810 + The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. + +The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. neuroendocrine cell + + + + A neuron that is capable of some hormone secretion in response to neuronal signals. + MESH:D055099 + + + + + The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. + +The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. + PMID:5342440 + https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073 + @@ -3307,8 +4345,102 @@ + Any secretory cell that is capable of some peptide hormone secretion. peptide hormone secreting cell + + + + Any secretory cell that is capable of some peptide hormone secretion. + FBC:Autogenerated + + + + + + + + + + + + + + + + + + + + + + + + + + + Any secretory cell that is capable of some insulin secretion. + BTO:0000783 + insulin secreting cell + + + + + Any secretory cell that is capable of some insulin secretion. + FBC:Autogenerated + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A cell that secretes insulin and is located towards the center of the islets of Langerhans. + BTO:0000783 + EV:0200009 + FMA:70586 + MA:0002419 + ncithesaurus:Beta_Cell + Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. + type B pancreatic cell + + + + + A cell that secretes insulin and is located towards the center of the islets of Langerhans. + GOC:tfm + ISBN:0517223651 + http://en.wikipedia.org/wiki/Pancreatic_b_cell + @@ -3333,8 +4465,60 @@ + A cell that secretes glucagon. + FMA:84045 glucagon secreting cell + + + + A cell that secretes glucagon. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon. + BTO:0000990 + FMA:70585 + MESH:D050416 + pancreatic A cell + + + + + A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon. + GOC:tfm + ISBN:0721662544 + @@ -3359,8 +4543,58 @@ + Any secretory cell that is capable of some somatostatin secretion. somatostatin secreting cell + + + + Any secretory cell that is capable of some somatostatin secretion. + FBC:Autogenerated + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin. + BTO:0000803 + FMA:70587 + pancreatic D cell + + + + + A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin. + FMA:0517223651 + GOC:tfm + @@ -3385,8 +4619,65 @@ + Any secretory cell that is capable of some steroid hormone secretion. steroid hormone secreting cell + + + + Any secretory cell that is capable of some steroid hormone secretion. + FBC:Autogenerated + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. + BTO:0000575 + CALOHA:TS-0454 + FMA:14515 + Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. + hepatocyte + + + + + The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. + GOC:tfm + ISBN:0412046911 + MESH:D022781 + PMID:19717280 + http://en.wikipedia.org/wiki/Hepatocyte + @@ -3394,8 +4685,15 @@ + A cell whose primary function is to shorten. contractile cell + + + + A cell whose primary function is to shorten. + FB:ma + @@ -3411,8 +4709,20 @@ + A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. + BTO:0000888 + BTO:0000902 + CALOHA:TS-2032 + FMA:67328 + WBbt:0003675 muscle cell + + + + A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. + MESH:D032342 + @@ -3437,9 +4747,18 @@ - + A somatic cell located in skeletal muscle. + BTO:0004392 + CALOHA:TS-2158 + FMA:9727 cell of skeletal muscle + + + + A somatic cell located in skeletal muscle. + GOC:tfm + @@ -3454,9 +4773,20 @@ - + A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast). + BTO:0004576 + CALOHA:TS-2159 + FMA:14072 smooth muscle cell + + + + A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast). + MESH:D032389 + PMID:9315361 + http://en.wikipedia.org/wiki/Smooth_muscle_cell + @@ -3492,6 +4822,7 @@ A cell that is capable of detection of a stimulus involved in sensory perception. + MESH:D011984 sensory receptor cell @@ -3518,8 +4849,15 @@ + A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. chemoreceptor cell + + + + A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. + MESH:D002628 + @@ -3544,8 +4882,18 @@ + A cell specialized to detect and transduce light. + BTO:0001060 + CALOHA:TS-0868 + FMA:86740 photoreceptor cell + + + + A cell specialized to detect and transduce light. + MESH:D010786 + @@ -3553,8 +4901,15 @@ + A cell whose function is determined by the generation or the reception of an electric signal. electrically active cell + + + + A cell whose function is determined by the generation or the reception of an electric signal. + FB:ma + @@ -3562,8 +4917,15 @@ + A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism. lining cell + + + + A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism. + JB:jb + @@ -3579,6 +4941,7 @@ A cell located in the synovial joint. + CALOHA:TS-0995 synovial cell @@ -3588,8 +4951,15 @@ + A cell whose primary function is to prevent the transport of stuff across compartments. barrier cell + + + + A cell whose primary function is to prevent the transport of stuff across compartments. + JB:jb + @@ -3614,8 +4984,15 @@ + A cell that moves by its own activities. motile cell + + + + A cell that moves by its own activities. + FB:ma + @@ -3629,8 +5006,16 @@ + A cell of the outer of the three germ layers of the embryo. + FMA:72549 ectodermal cell + + + + A cell of the outer of the three germ layers of the embryo. + MESH:D004475 + @@ -3644,8 +5029,16 @@ + A cell of the middle germ layer of the embryo. + FMA:72554 mesodermal cell + + + + A cell of the middle germ layer of the embryo. + MESH:D008648 + @@ -3659,8 +5052,16 @@ + A cell of the inner of the three germ layers of the embryo. + FMA:72555 endodermal cell + + + + A cell of the inner of the three germ layers of the embryo. + MESH:D004707 + @@ -3685,8 +5086,16 @@ + A cell with a single nucleus. single nucleate cell + + + + A cell with a single nucleus. + FB:ma + GOC:tfm + @@ -3711,8 +5120,17 @@ + A cell with more than one nucleus. + AEO:0000203 + WBbt:0008074 multinucleate cell + + + + A cell with more than one nucleus. + FB:ma + @@ -3773,9 +5191,19 @@ - + A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. + BTO:0000424 + CALOHA:TS-0290 + FMA:81100 erythrocyte + + + + A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. + GOC:tfm + MESH:D004912 + @@ -3802,8 +5230,19 @@ + Any cell capable of ingesting particulate matter via phagocytosis. + BTO:0001044 + FMA:83806 + MESH:D010586 phagocyte + + + + Any cell capable of ingesting particulate matter via phagocytosis. + GOC:add + ISBN:0721601464 + @@ -3844,9 +5283,25 @@ - + A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. + BTO:0000801 + CALOHA:TS-0587 + FMA:63261 + FMA:83585 + MESH:D008264 + Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. macrophage + + + + A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. + GOC:add + GOC:tfm + GO_REF:0000031 + PMID:16213494 + PMID:1919437 + @@ -3871,8 +5326,16 @@ + Any cell that only exists in Eukaryota. + MESH:D005057 eukaryotic cell + + + + Any cell that only exists in Eukaryota. + FBC:Autogenerated + @@ -3897,8 +5360,15 @@ + Any cell that only exists in Eumycetozoa. Eumycetozoan cell + + + + Any cell that only exists in Eumycetozoa. + FBC:Autogenerated + @@ -3923,9 +5393,15 @@ - + Any photoreceptor cell that is part of some eye. eye photoreceptor cell + + + + Any photoreceptor cell that is part of some eye. + FBC:Autogenerated + @@ -3933,8 +5409,15 @@ + A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. structural cell + + + + A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. + TAIR:sr + @@ -3964,8 +5447,18 @@ + A mature sexual reproductive cell having a single set of unpaired chromosomes. + CALOHA:TS-0395 + FMA:18649 gamete + + + + A mature sexual reproductive cell having a single set of unpaired chromosomes. + GOC:tfm + ISBN:0721662544 + @@ -4005,8 +5498,17 @@ + An epithelial cell found in the trachea. + FMA:74793 + This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell' tracheal epithelial cell + + + + An epithelial cell found in the trachea. + GOC:tfm + @@ -4014,8 +5516,53 @@ + Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid. + BTO:0003687 + FMA:62511 serous secreting cell + + + + Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid. + GOC:tfm + ISBN:0517223651 + ISBN:0721662544 + + + + + + + + + + + + + + + + + + + + + + + + + + Any secretory cell that is capable of some mucus secretion. + BTO:0003689 + mucus secreting cell + + + + + Any secretory cell that is capable of some mucus secretion. + FBC:Autogenerated + @@ -4030,8 +5577,20 @@ + An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates. + BTO:0000395 + CALOHA:TS-2168 + FMA:62499 pulmonary alveolar epithelial cell + + + + An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates. + GOC:tfm + PMID:20054144 + PMID:29463737 + @@ -4039,8 +5598,15 @@ + A cell that is specialised to accumulate a particular substance(s). stuff accumulating cell + + + + A cell that is specialised to accumulate a particular substance(s). + FB:ma + @@ -4074,8 +5640,15 @@ + Any cell that is capable of some oxygen transport. oxygen accumulating cell + + + + Any cell that is capable of some oxygen transport. + FBC:Autogenerated + @@ -4091,8 +5664,16 @@ + A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. + FMA:86667 migratory neural crest cell + + + + A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. + doi:10.1016/j.stem.2015.02.017 + @@ -4100,8 +5681,16 @@ + A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors. mesenchyme condensation cell + + + + A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors. + GOC:tfm + PMID:5025404 + @@ -4133,8 +5722,15 @@ + A cell of the sclera of the eye. scleral cell + + + + A cell of the sclera of the eye. + GOC:add + @@ -4166,8 +5762,15 @@ + A structural cell that is part of optic choroid. choroidal cell of the eye + + + + A structural cell that is part of optic choroid. + GOC:add + @@ -4192,8 +5795,15 @@ + Any cell that is part of some extraembryonic structure. extraembryonic cell + + + + Any cell that is part of some extraembryonic structure. + FBC:Autogenerated + @@ -4207,8 +5817,17 @@ + A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. + FMA:83028 trophoblast cell + + + + A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. + GOC:tfm + MESH:D014327 + @@ -4216,8 +5835,16 @@ + A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation. epiblast cell + + + + A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation. + GOC:tfm + ISBN:0618947256 + @@ -4225,8 +5852,17 @@ + An undifferentiated cell produced by early cleavages of the fertilized egg (zygote). + BTO:0001473 + FMA:72551 blastoderm cell + + + + An undifferentiated cell produced by early cleavages of the fertilized egg (zygote). + MESH:D001756 + @@ -4246,8 +5882,50 @@ + A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell. + FMA:86767 + Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo. multi-potent skeletal muscle stem cell + + + + A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell. + PMID:18282570 + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. + sphincter associated smooth muscle cell + + + + + A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. + GOC:cjm + @@ -4273,9 +5951,16 @@ - + A smooth muscle cell associated with the vasculature. vascular associated smooth muscle cell + + + + A smooth muscle cell associated with the vasculature. + GOC:dsd + GOC:tfm + @@ -4300,8 +5985,20 @@ + An epithelial cell of the integument (the outer layer of an organism). + BTO:0001470 + CALOHA:TS-0283 + FMA:62411 + MESH:D000078404 epidermal cell + + + + An epithelial cell of the integument (the outer layer of an organism). + Flybase:dsj + MA:ma + @@ -4328,8 +6025,18 @@ + Diploid cell produced by the fusion of sperm cell nucleus and egg cell. + BTO:0000854 + EHDAA2:0004546 + FMA:72395 animal zygote + + + + Diploid cell produced by the fusion of sperm cell nucleus and egg cell. + ISBN:0471245208 + @@ -4346,8 +6053,15 @@ + A cell whose function is determined by its response to an electric signal. electrically responsive cell + + + + A cell whose function is determined by its response to an electric signal. + FB:ma + @@ -4372,8 +6086,15 @@ + Any interneuron that has its soma located in some ganglion. ganglion interneuron + + + + Any interneuron that has its soma located in some ganglion. + FBC:Autogenerated + @@ -4393,9 +6114,16 @@ - + An interneuron that has its cell body in a central nervous system. + Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system. CNS interneuron + + + + An interneuron that has its cell body in a central nervous system. + doi:10.1016/B978-0-12-817424-1.00001-X + @@ -4403,8 +6131,50 @@ + A cell that initiates an electrical signal and passes that signal to another cell. electrically signaling cell + + + + A cell that initiates an electrical signal and passes that signal to another cell. + FB:ma + + + + + + + + + + + + + + + + + + + + + + + + + + A cell that contains more than two haploid sets of chromosomes. + polyploid cell + + + + + A cell that contains more than two haploid sets of chromosomes. + FB:ma + PMID:32646579 + https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy + @@ -4429,8 +6199,25 @@ + A cell whose nucleus contains a single haploid genome. haploid cell + + + + A cell whose nucleus contains a single haploid genome. + FB:ma + GOC:tfm + + + + + + + + + endopolyploid cell + @@ -4548,9 +6335,20 @@ - + A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative). + BTO:0002042 + CALOHA:TS-0194 + FMA:83036 + MESH:D003713 dendritic cell + + + + A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative). + GOC:add + ISBN:0781735149 + @@ -4584,8 +6382,16 @@ + A cell type that secretes 5-Hydroxytryptamine (serotonin). serotonin secreting cell + + + + A cell type that secretes 5-Hydroxytryptamine (serotonin). + GOC:tfm + PMID:19630576 + @@ -4610,8 +6416,16 @@ + A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. noradrenergic cell + + + + A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. + GOC:tfm + ISBN:068340007X + @@ -4619,8 +6433,15 @@ + A cell whose primary function is to protect the organism. defensive cell + + + + A cell whose primary function is to protect the organism. + JB:jb + @@ -4645,8 +6466,15 @@ + A photoreceptor cell that detects visible light. visible light photoreceptor cell + + + + A photoreceptor cell that detects visible light. + GOC:tfm + @@ -4661,9 +6489,113 @@ - + A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. + BTO:0002064 + FMA:83624 stromal cell + + + + A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. + GOC:tfm + MESH:D017154 + + + + + + + + + + A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. + FMA:62935 + type D enteroendocrine cell + + + + + A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. + MESH:D019864 + + + + + + + + + An endorphine cell that secretes enkephalin. + enkephalin secreting cell + + + + + An endorphine cell that secretes enkephalin. + GO:tfm + + + + + + + + + A peptide hormone secreting cell that secretes endorphin. + endorphin secreting cell + + + + + A peptide hormone secreting cell that secretes endorphin. + GO:tfm + + + + + + + + + + + + + + + + + + An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli. + BTO:0004108 + FMA:67609 + type G enteroendocrine cell + + + + + An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli. + GOC:tfm + ISBN:0517223651 + MESH:D019863 + + + + + + + + + A peptide hormone secreting cell that secretes gastrin. + gastrin secreting cell + + + + + A peptide hormone secreting cell that secretes gastrin. + GO:tfm + @@ -4693,8 +6625,17 @@ + A precursor cell destined to differentiate into cardiac muscle cell. + FMA:84797 cardiac muscle myoblast + + + + A precursor cell destined to differentiate into cardiac muscle cell. + GOC:tfm + MESH:D032386 + @@ -4719,8 +6660,17 @@ + A precursor cell destined to differentiate into smooth muscle myocytes. + FMA:84798 smooth muscle myoblast + + + + A precursor cell destined to differentiate into smooth muscle myocytes. + GOC:tfm + MESH:D032390 + @@ -4752,8 +6702,16 @@ + A myoblast that differentiates into skeletal muscle fibers. + FMA:84799 skeletal muscle myoblast + + + + A myoblast that differentiates into skeletal muscle fibers. + SANBI:mhl + @@ -4768,8 +6726,15 @@ + A phagocyte in vertebrates that is able to phagocytosis. phagocyte (sensu Vertebrata) + + + + A phagocyte in vertebrates that is able to phagocytosis. + GOC:tfm + @@ -4794,8 +6759,15 @@ + Any cell that only exists in Fungi. fungal cell + + + + Any cell that only exists in Fungi. + FBC:Autogenerated + @@ -4821,9 +6793,17 @@ - + A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy. + FMA:83043 syncytiotrophoblast cell + + + + A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy. + GOC:tfm + ISBN:0323052908 + @@ -4831,9 +6811,17 @@ - + A neuron which conveys sensory information centrally from the periphery. + FMA:87653 afferent neuron + + + + A neuron which conveys sensory information centrally from the periphery. + GOC:tfm + MESH:D009475 + @@ -4841,8 +6829,15 @@ + A neuron which sends impulses peripherally to activate muscles or secretory cells. efferent neuron + + + + A neuron which sends impulses peripherally to activate muscles or secretory cells. + MESH:D009476 + @@ -4858,9 +6853,22 @@ - + The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. + BTO:0000938 + CALOHA:TS-0683 + FMA:54527 + VHOG:0001483 + WBbt:0003679 + These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. neuron + + + + The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. + MESH:D009474 + http://en.wikipedia.org/wiki/Neuron + @@ -4916,9 +6924,23 @@ - + A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + BTO:0000775 + CALOHA:TS-0583 + FMA:62863 + MESH:D008214 + VHOG:0001535 + Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) lymphocyte + + + + A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + GOC:add + ISBN:0683073696 + ISBN:0781735149 + @@ -5094,8 +7116,17 @@ + An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. + FMA:83518 proerythroblast + + + + An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. + ISBN:0721601464 + PMID:1638021 + @@ -5140,8 +7171,17 @@ + A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers. + FMA:83505 basophilic erythroblast + + + + A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers. + GOC:tfm + ISBN:0721601464 + @@ -5192,8 +7232,16 @@ + A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers. + FMA:83506 polychromatophilic erythroblast + + + + A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers. + ISBN:0721601464 + @@ -5234,8 +7282,16 @@ + The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated. + FMA:84646 orthochromatic erythroblast + + + + The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated. + ISBN:0721601464 + @@ -5397,9 +7453,22 @@ - + The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative). + BTO:0001164 + CALOHA:TS-0610 + FMA:84235 + MESH:D055016 + Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. megakaryocyte progenitor cell + + + + The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative). + GOC:dsd + GOC:tfm + ISBN:0721601464 + @@ -5420,9 +7489,22 @@ - + A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release. + BTO:0000843 + CALOHA:TS-0611 + FMA:83555 + Megakaryocytes are reportedly CD181-positive and CD182-positive. megakaryocyte + + + + A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release. + ISBN:0721601464 + MESH:D008533 + PMID:31043076 + http://en.wikipedia.org/wiki/Megakaryocyte + @@ -5514,9 +7596,27 @@ - + A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. + Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. granulocyte monocyte progenitor cell + + + + A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. + GOC:amm + GOC:dsd + GOC:tfm + GO_REF:0000031 + ISBN:0721601464 + MESH:D055014 + PMCID:PMC2213186 + PMCID:PMC548021 + PMID:16551251 + PMID:16647566 + http://en.wikipedia.org/wiki/CFU-GM + http://www.copewithcytokines.de + @@ -5667,8 +7767,21 @@ + An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. + BTO:0001173 + CALOHA:TS-0864 + MESH:D012156 reticulocyte + + + + An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. + GOC:add + GOC:tfm + PMID:15946868 + PMID:2037622 + @@ -5714,9 +7827,19 @@ - + A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules. + BTO:0004657 + FMA:83551 + Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. promonocyte + + + + A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules. + GOC:tfm + ISBN:0721601464 + @@ -5742,8 +7865,16 @@ + An erythrocyte having a nucleus. nucleate erythrocyte + + + + An erythrocyte having a nucleus. + GOC:add + GOc:tfm + @@ -5795,8 +7926,18 @@ + A mesenchymal stem cell capable of developing into blood vessel endothelium. + These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. angioblastic mesenchymal cell + + + + A mesenchymal stem cell capable of developing into blood vessel endothelium. + GOC:dsd + GOC:tfm + PMID:12768659 + @@ -5822,8 +7963,15 @@ + A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field. cardiac mesenchymal cell + + + + A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field. + PMID:18816864 + @@ -5837,9 +7985,18 @@ - + One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. + BTO:0001036 + CALOHA:TS-0866 + FMA:67748 retinal cone cell + + + + One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. + MESH:D017949 + @@ -5865,9 +8022,18 @@ - + An epithelial cell of the cornea. + BTO:0004298 + CALOHA:TS-0173 + FMA:70551 corneal epithelial cell + + + + An epithelial cell of the cornea. + GOC:tfm + @@ -5924,9 +8090,20 @@ - + Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells. + BTO:0000876 + CALOHA:TS-0638 + FMA:62864 + Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. monocyte + + + + Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells. + GO_REF:0000031 + MESH:D009000 + @@ -6030,15 +8207,42 @@ + + + + + + - + A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative. + BTO:0000802 + CALOHA:TS-0030 + FMA:83023 + A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8. + Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. alveolar macrophage + + + + A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative. + GOC:ana + GOC:dsd + GOC:tfm + GO_REF:0000031 + MESH:D016676 + + + + + A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8. + https://doi.org/10.5281/zenodo.11165918 + @@ -6052,8 +8256,19 @@ + The reproductive cell in multicellular organisms. + BTO:0000535 + NCIT:C12597 + VHOG:0001534 + WBbt:0006796 germ cell + + + + The reproductive cell in multicellular organisms. + MESH:D005854 + @@ -6078,8 +8293,15 @@ + A steroid hormone secreting cell that secretes androgen. androgen secreting cell + + + + A steroid hormone secreting cell that secretes androgen. + GOC:tfm + @@ -6093,9 +8315,44 @@ - + One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. + BTO:0001024 + CALOHA:TS-0870 + FMA:67747 retinal rod cell + + + + One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. + MESH:D017948 + + + + + + + + + + + + + + + + A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). + FMA:83625 + MESH:D061354 + acinar cell + + + + + A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). + GOC:tfm + http://www.copewithcytokines.de + @@ -6103,8 +8360,50 @@ + A cell whose primary function is to support other cell types. + BTO:0002315 supporting cell + + + + A cell whose primary function is to support other cell types. + FB:ma + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues. + fenestrated endothelial cell + + + + + An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues. + DOI:10.1007/978-3-211-99390-3_133 + @@ -6112,8 +8411,15 @@ + An extracellular matrix secreting cell that secretes collagen. collagen secreting cell + + + + An extracellular matrix secreting cell that secretes collagen. + GOC:tfm + @@ -6124,9 +8430,24 @@ - + An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. + BTO:0002441 + FMA:63174 + Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A. pericyte + + + + An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. + GOC:dsd + GOC:tfm + ISBN:0721662544 + MESH:D020286 + PMID:16807374 + PMID:17986482 + PMID:20024907 + @@ -6156,8 +8477,17 @@ + A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells. + FMA:70567 primordial germ cell + + + + A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells. + GOC:tfm + PMID:1381289 + @@ -6166,8 +8496,15 @@ + A mature sexual reproductive cell of the female germline. female gamete + + + + A mature sexual reproductive cell of the female germline. + GOC:tfm + @@ -6199,8 +8536,15 @@ + A non-terminally differentiated cell that is capable of developing into a muscle cell. muscle precursor cell + + + + A non-terminally differentiated cell that is capable of developing into a muscle cell. + GOC:add + @@ -6209,8 +8553,19 @@ + A cell that stores and secretes pancreatic polypeptide hormone. + FMA:62938 + FMA:83409 PP cell + + + + A cell that stores and secretes pancreatic polypeptide hormone. + GOC:tfm + JB:jb + PMID:15153415 + @@ -6236,8 +8591,18 @@ + Epithelial cells derived from neural plate and neural crest. + BTO:0004301 + FMA:70557 + The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). neurecto-epithelial cell + + + + Epithelial cells derived from neural plate and neural crest. + GOC:tfm + @@ -6262,8 +8627,17 @@ + A stem cell that can give rise to cell types of the body other than those of the germ-line. + CALOHA:TS-2086 + MESH:D053687 somatic stem cell + + + + A stem cell that can give rise to cell types of the body other than those of the germ-line. + GO:0048103 + @@ -6299,8 +8673,19 @@ + Muscle cell which has as its direct parts myofilaments organized into sarcomeres. + BTO:0002916 + CALOHA:TS-2157 + FMA:86936 striated muscle cell + + + + Muscle cell which has as its direct parts myofilaments organized into sarcomeres. + GOC:tfm + ISBN:0721662544 + @@ -6351,9 +8736,22 @@ - + An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + BTO:0000751 + CALOHA:TS-0549 + FMA:62852 + MESH:D007962 + NCIT:C12529 leukocyte + + + + An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + GOC:add + GOC:tfm + ISBN:978-0-323-05290-0 + @@ -6367,9 +8765,18 @@ - + The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve. + BTO:0001800 + FMA:67765 + MESH:D012165 retinal ganglion cell + + + + The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve. + GOC:dph + @@ -6419,9 +8826,24 @@ - + Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. + BTO:0001539 + CALOHA:TS-0115 + FMA:14067 + MESH:D032383 + This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. cardiac muscle cell + + + + Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. + GOC:mtg_cardiacconduct_nov11 + GOC:tfm + ISBN:0323052908 + PMID:22426062 + PMID:4711263 + @@ -6447,8 +8869,18 @@ + A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. + BTO:0001441 + CALOHA:TS-0647 + MESH:D022423 myeloid cell + + + + A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. + GOC:add + @@ -6456,9 +8888,20 @@ - + A immature or mature cell in the lineage leading to and including erythrocytes. + CALOHA:TS-0290 + FMA:62845 + FMA:83516 + Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. erythroid lineage cell + + + + A immature or mature cell in the lineage leading to and including erythrocytes. + GOC:add + GOC:tfm + @@ -6620,8 +9063,21 @@ + A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers. + BTO:0001571 + CALOHA:TS-0289 + FMA:83504 + MESH:D004900 erythroblast + + + + A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers. + GOC:add + ISBN:0721601464 + PMID:18174176 + @@ -6641,8 +9097,15 @@ + A cell of the monocyte, granulocyte, or mast cell lineage. myeloid leukocyte + + + + A cell of the monocyte, granulocyte, or mast cell lineage. + GOC:add + @@ -6662,8 +9125,21 @@ + A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts. + Morphology: mononuclear, highly vesicular. mononuclear osteoclast + + + + A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts. + GOC:add + GOC:tfm + PMID:12713016 + PMID:15055519 + PMID:17380158 + PMID:9415452 + @@ -6689,8 +9165,18 @@ + A specialized multinuclear osteoclast associated with the absorption and removal of bone. + Morphology: multinucleated, highly vesicular. multinuclear osteoclast + + + + A specialized multinuclear osteoclast associated with the absorption and removal of bone. + GOC:add + PMID:12713016 + PMID:9415452 + @@ -6726,8 +9212,20 @@ + A dendritic cell of the myeloid lineage. + BTO:0004721 + These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). myeloid dendritic cell + + + + A dendritic cell of the myeloid lineage. + GOC:add + PMID:10449155 + PMID:17332250 + PMID:9521319 + @@ -6747,8 +9245,16 @@ + A phagocyte formed by the fusion of mononuclear phagocytes. multinucleated phagocyte + + + + A phagocyte formed by the fusion of mononuclear phagocytes. + GOC:add + GOC:tfm + @@ -6779,8 +9285,16 @@ + A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage. pro-T cell + + + + A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage. + GOC:add + ISBN:0781735149 + @@ -6842,8 +9356,20 @@ + The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow. + BTO:0000187 + FMA:83524 myeloblast + + + + The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow. + GOC:add + ISBN:0721601464 + http://en.wikipedia.org/wiki/Myeloblast + http://www.cap.org + @@ -7016,9 +9542,20 @@ - + A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans. + BTO:0000725 + CALOHA:TS-0448 + Markers differ between mouse and human. hematopoietic multipotent progenitor cell + + + + A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans. + GOC:add + GOC:tfm + PMID:19022770 + @@ -7045,8 +9582,20 @@ + A progenitor cell restricted to the lymphoid lineage. + BTO:0004731 + CALOHA:TS-2025 + FMA:70338 + Note that this is a class of cell types, not an identified single cell type. lymphoid lineage restricted progenitor cell + + + + A progenitor cell restricted to the lymphoid lineage. + GOC:add + GOC:tfm + @@ -7072,9 +9621,21 @@ - + A progenitor cell restricted to the myeloid lineage. + BTO:0004730 + CALOHA:TS-2099 + FMA:70339 + Note that this is a class of cell types, not an identified single cell type. myeloid lineage restricted progenitor cell + + + + A progenitor cell restricted to the myeloid lineage. + GOC:add + GOC:tfm + PMID:19022770 + @@ -7094,8 +9655,18 @@ + A leukocyte with a single non-segmented nucleus in the mature form. + BTO:0000878 + CALOHA:TS-0768 + FMA:86713 mononuclear cell + + + + A leukocyte with a single non-segmented nucleus in the mature form. + GOC:add + @@ -7174,9 +9745,21 @@ - + A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes. + Markers: CCR2+CXCCR1<low> (human, mouse, rat). classical monocyte + + + + A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes. + GOC:add + GO_REF:0000031 + PMID:16322748 + PMID:18303997 + PMID:20628149 + PMID:20870168 + @@ -7237,8 +9820,22 @@ + A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive. + FMA:84643 + FMA:84645 + Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). elicited macrophage + + + + A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive. + GOC:add + GOC:ana + GOC:tfm + GO_REF:0000031 + PMID:15771589 + @@ -7263,8 +9860,18 @@ + A macrophage that suppresses immune responses. + Markers: May express: IL10, TGFbeta. suppressor macrophage + + + + A macrophage that suppresses immune responses. + GOC:add + GOC:tfm + PMID:20402419 + @@ -7289,8 +9896,19 @@ + A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. + FMA:84642 + FMA:84644 tissue-resident macrophage + + + + A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. + GOC:ana + GO_REF:0000031 + PMID:19770654 + @@ -7316,8 +9934,16 @@ + A tissue-resident macrophage found in the central nervous system. central nervous system macrophage + + + + A tissue-resident macrophage found in the central nervous system. + GO_REF:0000031 + PMID:16322748 + @@ -7393,9 +10019,21 @@ - + A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative. + Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. early lymphoid progenitor + + + + A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative. + GOC:add + GOC:dsd + GOC:pam + GOC:tfm + GO_REF:0000031 + PMID:19022770 + @@ -7403,8 +10041,20 @@ + A cell of a hematopoietic lineage. + BTO:0000574 + CALOHA:TS-2017 + FMA:70366 + FMA:83598 hematopoietic cell + + + + A cell of a hematopoietic lineage. + GOC:add + GO_REF:0000031 + @@ -7429,9 +10079,19 @@ - + Conventional dendritic cell is a dendritic cell that is CD11c-high. + FMA:84191 + Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. conventional dendritic cell + + + + Conventional dendritic cell is a dendritic cell that is CD11c-high. + GOC:amm + GO_REF:0000031 + PMID:17850486 + @@ -7447,6 +10107,7 @@ + Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617). CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor @@ -7556,8 +10217,21 @@ + A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative. + Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617). Kit and Sca1-positive hematopoietic stem cell + + + + A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative. + GOC:add + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:17952047 + PMID:19022770 + @@ -7573,6 +10247,7 @@ + Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor @@ -7590,6 +10265,7 @@ + Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). CD115-positive monocyte OR common dendritic progenitor @@ -7654,8 +10330,21 @@ + A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive. + These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617). CD34-positive, CD38-positive common lymphoid progenitor + + + + A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive. + GOC:add + GOC:amm + GOC:tfm + GO_REF:0000031 + PMCID:PMC2346585 + PMID:19022770 + @@ -7698,8 +10387,19 @@ + CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive. + These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). CD115-positive monocyte + + + + CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive. + GOC:add + GOC:amm + GO_REF:0000031 + PMID:17952047 + @@ -7772,8 +10472,22 @@ + A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low. + Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617). Kit-positive, CD34-positive common myeloid progenitor + + + + A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low. + GOC:add + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:1261582 + PMID:17952047 + http://www.immgen.org/index_content.html + @@ -7872,8 +10586,25 @@ + CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive. + CALOHA:TS-0448 + Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617). CD34-positive, CD38-negative hematopoietic stem cell + + + + CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive. + GOC:add + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:10430905 + PMID:11750107 + PMID:16551251 + PMID:20024907 + PMID:9389721 + @@ -7965,8 +10696,21 @@ + A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low. + Markers are associated with mouse cells. Kit-positive, Sca1-positive common lymphoid progenitor + + + + A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low. + GOC:add + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:17952047 + http://www.immgen.org/index_content.html + @@ -8048,8 +10792,20 @@ + A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative. + Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617). CD34-positive, CD38-positive common myeloid progenitor + + + + A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative. + GOC:add + GOC:amm + GO_REF:0000031 + PMCID:PMC2626675 + PMID:16551251 + @@ -8101,8 +10857,18 @@ + CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative. + These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617). CD7-negative lymphoid progenitor cell + + + + CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative. + GOC:amm + GO_REF:0000031 + PMID:16551251 + @@ -8153,8 +10919,20 @@ + CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative. + These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). CD7-positive lymphoid progenitor cell + + + + CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative. + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:16551251 + PMID:19491395 + @@ -8326,8 +11104,21 @@ + Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers. + Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). common dendritic progenitor + + + + Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers. + GOC:amm + GOC:tfm + GO_REF:0000031 + PMID:16551251 + PMID:17922016 + PMID:19286519 + @@ -8343,6 +11134,7 @@ + Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617). CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor @@ -8369,9 +11161,16 @@ - + A connective tissue cell found in bone. bone cell + + + + A connective tissue cell found in bone. + GOC:add + GO_REF:0000034 + @@ -8426,9 +11225,17 @@ - + A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20. + This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes. CD14-positive monocyte + + + + A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20. + GOC:add + PMID:22343568 + @@ -8508,8 +11315,23 @@ + A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1. + CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. common myeloid progenitor, CD34-positive + + + + A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1. + GOC:add + GOC:dsd + GOC:tfm + ISBN:0878932437 + PMCID:PMC2212039 + PMID:10724173 + PMID:16551251 + PMID:16647566 + @@ -8648,8 +11470,16 @@ + A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. hematopoietic oligopotent progenitor cell, lineage-negative + + + + A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. + GOC:tfm + PMID:19022770 + @@ -8794,8 +11624,17 @@ + A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative). + BTO:0004911 erythroid progenitor cell, mammalian + + + + A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative). + GOC:add + ISBN:0721601464 + @@ -8896,8 +11735,19 @@ + An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative. + Markers found on mouse cells. Kit-positive erythroid progenitor cell + + + + An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative. + GOC:ak + GOC:tfm + PMID:19805084 + http://www.immgen.org/index_content.html + @@ -8942,8 +11792,18 @@ + A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative. + Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. CD34-positive, CD38-positive granulocyte monocyte progenitor + + + + A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative. + GOC:tfm + PMID:12615892 + PMID:19022770 + @@ -9044,8 +11904,21 @@ + A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative. + Markers are found on mouse cells. Kit-positive granulocyte monocyte progenitor + + + + A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative. + GOC:tfm + PMID:12615892 + PMID:16322423 + PMID:19022770 + PMID:19273628 + http://www.immgen.org/index_content.html + @@ -9086,8 +11959,19 @@ + An erythroid progenitor cell that is CD34-positive and is GlyA-negative. + FMA:83517 + Cell markers associated with human cells. CD34-positive, GlyA-negative erythroid progenitor cell + + + + An erythroid progenitor cell that is CD34-positive and is GlyA-negative. + GOC:ak + GOC:tfm + PMID:19621348 + @@ -9128,8 +12012,18 @@ + A proerythoblast that is CD34-negative and GlyA-negative. + Cell surface markers are associated with human cells. CD34-negative, GlyA-negative proerythroblast + + + + A proerythoblast that is CD34-negative and GlyA-negative. + GOC:ak + GOC:tfm + PMID:19621348 + @@ -9184,8 +12078,18 @@ + A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative. + Markers are associated with human cell type. CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell + + + + A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative. + GOC:tfm + PMID:12615892 + PMID:190227700 + @@ -9270,8 +12174,19 @@ + A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low. + Markers are associated with mouse cells. Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell + + + + A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low. + GOC:tfm + PMID:12615892 + PMID:19022770 + http://www.immgen.org/index_content.html + @@ -9314,8 +12229,16 @@ + A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. macrophage dendritic cell progenitor + + + + A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. + GOC:tfm + PMID:19273628 + @@ -9497,8 +12420,15 @@ + A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha. pre-conventional dendritic cell + + + + A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha. + GOC:tfm + @@ -9559,8 +12489,17 @@ + A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative. + Markers are associated with mouse cells. Kit-positive macrophage dendritic cell progenitor + + + + A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative. + GOC:tfm + PMID:19273628 + @@ -9631,8 +12570,18 @@ + A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive. + Markers are associated with mouse cells. Kit-low proerythroblast + + + + A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive. + GOC:ak + GOC:tfm + PMID:19805084 + @@ -9673,8 +12622,18 @@ + A basophilic erythroblast that is GlyA-positive. + Markers are associated with human cells. GlyA-positive basophilic erythroblast + + + + A basophilic erythroblast that is GlyA-positive. + GOC:ak + GOC:tfm + PMID:1638021 + @@ -9735,8 +12694,18 @@ + A basophilic erythroblast that is Lyg 76-high and is Kit-negative. + Cell surface markers are associated with mouse cells. Kit-negative, Ly-76 high basophilic erythroblast + + + + A basophilic erythroblast that is Lyg 76-high and is Kit-negative. + GOC:ak + GOC:tfm + PMID:19805084 + @@ -9797,8 +12766,17 @@ + A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative. Kit-negative, Ly-76 high polychromatophilic erythroblast + + + + A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative. + GOC:ak + GOC:tfm + PMID:19805084 + @@ -9839,8 +12817,18 @@ + A polychromatiic erythroblast that is Gly-A-positive and CD71-low. + Cell surface markers are associated with human cells. CD71-low, GlyA-positive polychromatic erythroblast + + + + A polychromatiic erythroblast that is Gly-A-positive and CD71-low. + GOC:ak + GOC:tfm + PMID:1638021 + @@ -9911,8 +12899,18 @@ + An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative. + Cell surface markers associated with mouse cells. Kit-negative, Ly-76 high orthochromatophilic erythroblasts + + + + An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative. + GOC:ak + GOC:tfm + PMID:19805084 + @@ -9953,8 +12951,18 @@ + An erythroblast that is GlyA-positive and CD71-negative. + Markers associated with human cells. CD71-negative, GlyA-positive orthochromatic erythroblast + + + + An erythroblast that is GlyA-positive and CD71-negative. + GOC:ak + GOC:tfm + PMID:1638021 + @@ -9987,8 +12995,16 @@ + A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. hematopoietic lineage restricted progenitor cell + + + + A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. + GOC:tfm + PMID:19022770 + @@ -10020,8 +13036,18 @@ + A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. + This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060). hematopoietic oligopotent progenitor cell + + + + A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. + GOC:tfm + PMID:19022770 + https://orcid.org/0000-0001-5208-3432 + @@ -10066,8 +13092,18 @@ + A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative. + Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low. short term hematopoietic stem cell + + + + A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative. + GOC:tfm + PMID:15572596 + PMID:19022770 + @@ -10116,8 +13152,18 @@ + A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative. + Markers are associated with mouse cells. long term hematopoietic stem cell + + + + A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative. + GOC:tfm + PMID:15572596 + PMID:17582345 + @@ -10178,8 +13224,17 @@ + A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative. + Markers are associated with mouse cells. Slamf1-negative multipotent progenitor cell + + + + A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative. + GOC:tfm + PMID:19022770 + @@ -10231,8 +13286,17 @@ + A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive. + Markers are associated with mouse cells. Slamf1-positive multipotent progenitor cell + + + + A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive. + GOC:tfm + PMID:19022770 + @@ -10287,8 +13351,18 @@ + A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative. + Cell markers are associated with human hematopoietic multipotent progenitor cells. CD34-positive, CD38-negative multipotent progenitor cell + + + + A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative. + GOC:tfm + PMID:18371405 + PMID:19022770 + @@ -10313,9 +13387,20 @@ - + A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange. + BTO:0000780 + FMA:62500 pulmonary alveolar type 1 cell + + + + A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange. + GOC:tfm + PMID:20054144 + PMID:29463737 + http://www.copewithcytokines.de + @@ -10346,9 +13431,67 @@ - + A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli. + BTO:0000538 + FMA:62501 pulmonary alveolar type 2 cell + + + + A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli. + GOC:tfm + ISBN:0412046911 + PMID:36138472 + PMID:8540632 + http://www.copewithcytokines.de + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules. + BTO:0000028 + CALOHA:TS-0737 + FMA:63032 + pancreatic acinar cell + + + + + A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules. + GOC:tfm + ISBN:0517223651 + PMID:20395539 + http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells + @@ -10368,8 +13511,17 @@ + An enteroendocrine cell that produces glucagon. + FMA:62939 type A enteroendocrine cell + + + + An enteroendocrine cell that produces glucagon. + GOC:tfm + ISBN:0412046911 + @@ -10377,9 +13529,19 @@ - + Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter. + BTO:0001032 + FMA:14146 Purkinje myocyte + + + + Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter. + FMA:0412046911 + GOC:tfm + PMID:19939742 + @@ -10387,8 +13549,18 @@ + A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery. + BTO:0004190 + FMA:67101 nodal myocyte + + + + A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery. + FMA:67101 + GOC:tfm + @@ -10396,8 +13568,17 @@ + Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes. + FMA:67142 transitional myocyte + + + + Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes. + FMA:67142 + GOC:tfm + @@ -10406,8 +13587,17 @@ + The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides). + FMA:67111 myocardial endocrine cell + + + + The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides). + FMA:67111 + GOC:tfm + @@ -10433,8 +13623,17 @@ + An epithelial cell derived from endoderm. + FMA:69075 endo-epithelial cell + + + + An epithelial cell derived from endoderm. + FMA:69075 + GOC:tfm + @@ -10460,8 +13659,17 @@ + An epithelial cell derived from ectoderm. + FMA:69074 ecto-epithelial cell + + + + An epithelial cell derived from ectoderm. + FMA:69074 + GOC:tfm + @@ -10487,8 +13695,111 @@ + Epithelial cell derived from mesoderm or mesenchyme. + FMA:69076 meso-epithelial cell + + + + Epithelial cell derived from mesoderm or mesenchyme. + FMA:69076 + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH. + FMA:63099 + pancreatic ductal cell + + + + + Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH. + FMA:63099 + GOC:tfm + PMID:14740223 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types. + FMA:62455 + pancreatic centro-acinar cell + + + + + A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types. + GOC:tfm + PMID:12142741 + PMID:20018761 + PMID:8185160 + @@ -10496,8 +13807,17 @@ + A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart. + FMA:67968 specialized cardiac myocyte + + + + A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart. + FMA:67968 + GOC:tfm + @@ -10522,8 +13842,54 @@ + A leukocyte that lacks granules. + FMA:62855 nongranular leukocyte + + + + A leukocyte that lacks granules. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise. + BTO:0003914 + FMA:86573 + Some argue this cell type is of mesenchymal origin. + interstitial cell of Cajal + + + + + This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise. + GOC:tfm + PMID:16460275 + PMID:19520112 + @@ -10548,8 +13914,20 @@ + A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. + BTO:0004850 + FMA:83621 + MESH:D001854 + MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. bone marrow cell + + + + A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. + GOC:tfm + ISBN:0618947256 + @@ -10558,9 +13936,17 @@ - + A cell in the hilum of the ovary that produces androgens. + FMA:18710 hilus cell of ovary + + + + A cell in the hilum of the ovary that produces androgens. + GOC:tfm + ISBN:068340007X + @@ -10585,8 +13971,16 @@ + A stomal cell of the ovary + FMA:72299 stromal cell of ovary + + + + A stomal cell of the ovary + GOC:tfm + @@ -10594,8 +13988,21 @@ + An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. + BTO:0001854 + CALOHA:TS-1106 + FMA:67755 + These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. endothelial cell of vascular tree + + + + An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. + GOC:dsd + GOC:tfm + PMID:12768659 + @@ -10621,9 +14028,18 @@ - + An endothelial cell found in capillaries. + BTO:0004956 + CALOHA:TS-0112 + FMA:67756 capillary endothelial cell + + + + An endothelial cell found in capillaries. + GOC:tfm + @@ -10639,9 +14055,17 @@ - + A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree. + FMA:70542 ciliated columnar cell of tracheobronchial tree + + + + A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree. + GOC:tfm + ISBN:0517223651 + @@ -10649,8 +14073,16 @@ + Epithelial cells derived from general body ectoderm and ectoderm placodes. + FMA:70556 general ecto-epithelial cell + + + + Epithelial cells derived from general body ectoderm and ectoderm placodes. + GOC:tfm + @@ -10675,8 +14107,16 @@ + An epithelial cell found in the lining of the stomach. + FMA:62948 epithelial cell of stomach + + + + An epithelial cell found in the lining of the stomach. + GOC:tfm + @@ -10701,8 +14141,16 @@ + A mucous cell in the epithelium of the stomach. + FMA:63464 mucous cell of stomach + + + + A mucous cell in the epithelium of the stomach. + GOC:tfm + @@ -10729,8 +14177,17 @@ + A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit. + FMA:62953 stem cell of gastric gland + + + + A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit. + GOC:tfm + ISBN:0517223651 + @@ -10755,8 +14212,16 @@ + A cell involved in the formation of a granulocyte. + FMA:83519 granulocytopoietic cell + + + + A cell involved in the formation of a granulocyte. + GOC:tfm + @@ -10781,8 +14246,51 @@ + A cell involved in the formation of a monocyte (monopoiesis). + FMA:83552 monopoietic cell + + + + A cell involved in the formation of a monocyte (monopoiesis). + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes). + FMA:86577 + hepatic stem cell + + + + + A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes). + GOC:tfm + PMID:26798363 + @@ -10807,8 +14315,16 @@ + An epithelial cell of the tracheobronchial tree. + FMA:66816 epithelial cell of tracheobronchial tree + + + + An epithelial cell of the tracheobronchial tree. + GOC:tfm + @@ -10816,8 +14332,17 @@ + An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells. + FMA:69060 intermediate epitheliocyte + + + + An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells. + GOC:tfm + ISBN:0517223651 + @@ -10832,8 +14357,17 @@ + A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye. + FMA:70950 vertebrate lens cell + + + + A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye. + GOC:tfm + ISBN:0721662544 + @@ -10859,9 +14393,18 @@ - + A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. + FMA:67559 lens epithelial cell + + + + A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. + GOC:tfm + ISBN:0721662544 + http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium + @@ -10881,8 +14424,16 @@ + A fibroblast in the bone marrow. + FMA:84377 marrow fibroblast + + + + A fibroblast in the bone marrow. + GOC:tfm + @@ -10912,8 +14463,16 @@ + A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis. + FMA:84467 pulmonary interstitial fibroblast + + + + A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis. + GOC:tfm + @@ -10938,8 +14497,58 @@ + A cell containing at least one nucleus. + FMA:67513 nucleate cell + + + + A cell containing at least one nucleus. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells. + FMA:70611 + smooth muscle cell of sphincter of pupil + + + + + A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells. + GOC:tfm + ISBN:0721662544 + ISBN:0721694128 + @@ -10965,8 +14574,18 @@ + A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells). + BTO:0002669 + FMA:86711 + MESH:D000072916 peripheral blood stem cell + + + + A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells). + GOC:tfm + @@ -10991,8 +14610,16 @@ + An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. epithelial cell of alimentary canal + + + + An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. + GOC:tfm + ISBN:0721662544 + @@ -11017,8 +14644,85 @@ + An epithelial cell of the esophagus. + FMA:63071 epithelial cell of esophagus + + + + An epithelial cell of the esophagus. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the large intestine. + BTO:0004297 + FMA:256157 + epithelial cell of large intestine + + + + + An epithelial cell of the large intestine. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the small intestine. + FMA:256159 + epithelial cell of small intestine + + + + + An epithelial cell of the small intestine. + GOC:tfm + @@ -11043,9 +14747,17 @@ - + An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver. + FMA:63134 endothelial cell of sinusoid + + + + An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver. + GOC:tfm + ISBN:0618947256 + @@ -11065,8 +14777,145 @@ + A type of enteroendocrine cell found in the stomach that secretes glucagon. + FMA:83411 type A cell of stomach + + + + A type of enteroendocrine cell found in the stomach that secretes glucagon. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + A D cell located in the colon. + FMA:268744 + type D cell of colon + + + + + A D cell located in the colon. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + A type D cell of the small intestine. + FMA:268736 + type D cell of small intestine + + + + + A type D cell of the small intestine. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + A type D cell found in the stomach. + FMA:83410 + type D cell of stomach + + + + + A type D cell found in the stomach. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A PP cell located in the islets of the pancreas. + BTO:0000805 + FMA:70588 + MESH:D050418 + The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. + pancreatic PP cell + + + + + A PP cell located in the islets of the pancreas. + GOC:tfm + @@ -11091,8 +14940,16 @@ + An epithelial cell of a skin gland. + FMA:70657 epithelial cell of skin gland + + + + An epithelial cell of a skin gland. + GOC:tfm + @@ -11117,8 +14974,18 @@ + A cell that is part of the nervous system. + CALOHA:TS-2040 + FMA:70333 neural cell + + + + A cell that is part of the nervous system. + GOC:tfm + ISBN:0618947256 + @@ -11143,8 +15010,19 @@ + A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. + CALOHA:TS-2096 + FMA:63875 + MESH:D003239 connective tissue cell + + + + A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. + GOC:tfm + ISBN:0618947256 + @@ -11152,8 +15030,18 @@ + A cell of the embryo. + CALOHA:TS-0263 + FMA:82840 + WBbt:0007028 embryonic cell (metazoa) + + + + A cell of the embryo. + FMA:0618947256 + @@ -11178,8 +15066,16 @@ + An epithelial cell of the bronchus. + BTO:0002922 bronchial epithelial cell + + + + An epithelial cell of the bronchus. + GOC:tfm + @@ -11199,9 +15095,16 @@ - + A ciliated cell of the bronchus. ciliated cell of the bronchus + + + + A ciliated cell of the bronchus. + GOC:tfm + PMID:18757316 + @@ -11232,8 +15135,16 @@ + An adipocyte derived from a neural crest cell. neural crest derived adipocyte + + + + An adipocyte derived from a neural crest cell. + GOC:tfm + PMID:17507398 + @@ -11258,9 +15169,36 @@ - + An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin. + FMA:75621 endocardial cell + + + + An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin. + GOC:tfm + ISSN:0452-3458 + + + + + + + + + A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1. + progenitor cell of endocrine pancreas + + + + + A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1. + GOC:tfm + PMID:20025937 + PMID:20217494 + PMID:22728667 + @@ -11285,8 +15223,16 @@ + A hematopoietic stem cell that exists during embryogenesis. gestational hematopoietic stem cell + + + + A hematopoietic stem cell that exists during embryogenesis. + GOC:tfm + ISBN:978-60327-246-6 + @@ -11311,9 +15257,16 @@ - + A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate. keratocyte + + + + A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate. + GOC:tfm + ISBN:9780702029585 + @@ -11338,8 +15291,16 @@ + An endo-epithelial cell of the respiratory tract. + BTO:0004533 respiratory epithelial cell + + + + An endo-epithelial cell of the respiratory tract. + GOC:tfm + @@ -11373,8 +15334,18 @@ + A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. myotube + + + + A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. + GOC:dos + GOC:tfm + ISBN:0323052908 + PMID:22274696 + @@ -11409,8 +15380,19 @@ + A CD14-positive monocyte that is also CD16-positive and CCR2-negative. + This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+). CD14-positive, CD16-positive monocyte + + + + A CD14-positive monocyte that is also CD16-positive and CCR2-negative. + GOC:tfm + PMID:20628149 + PMID:21937707 + PMID:22343568 + @@ -11430,8 +15412,18 @@ + A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles. nucleated reticulocyte + + + + A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles. + GOC:tfm + PMID:18182572 + PMID:9011180 + PMID:9046052 + @@ -11466,8 +15458,16 @@ + Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive. Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell + + + + Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive. + GOC:tfm + http://www.immgen.org/index_content.html + @@ -11510,8 +15510,16 @@ + A F4/80-negative dendritic cell located in adipose tissue. adipose dendritic cell + + + + A F4/80-negative dendritic cell located in adipose tissue. + GOC:tfm + http://www.immgen.org/index_content.html + @@ -11536,8 +15544,16 @@ + An adipose dendritic cell that is SIRPa-positive. SIRPa-positive adipose dendritic cell + + + + An adipose dendritic cell that is SIRPa-positive. + GOC:tfm + http://www.immgen.org/index_content.html + @@ -11562,8 +15578,16 @@ + An adipose dendritic cell that is SIRPa-negative. SIRPa-negative adipose dendritic cell + + + + An adipose dendritic cell that is SIRPa-negative. + GOC:tfm + http://www.immgen.org/index_content.html + @@ -11588,8 +15612,16 @@ + A conventional dendritic cell that expresses CD11b (ITGAM). CD11b-positive dendritic cell + + + + A conventional dendritic cell that expresses CD11b (ITGAM). + GOC:tfm + http://www.immgen.org/index_content.html + @@ -11614,8 +15646,20 @@ + A cell located in the heart, including both muscle and non muscle cells. + BTO:0001539 + CALOHA:TS-0115 + FMA:83808 + FMA:84791 + From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. cardiocyte + + + + A cell located in the heart, including both muscle and non muscle cells. + GOC:tfm + @@ -11641,8 +15685,50 @@ + A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc + BTO:0002441 + FMA:84639 adventitial cell + + + + A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell of the intestine. + enteric smooth muscle cell + + + + + A smooth muscle cell of the intestine. + GOC:tfm + @@ -11667,9 +15753,49 @@ - + An adipocyte that is part of subcutaneous adipose tissue. subcutaneous adipocyte + + + + An adipocyte that is part of subcutaneous adipose tissue. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes. + intrahepatic cholangiocyte + + + + + An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes. + GOC:tfm + PMID:23720296 + @@ -11694,8 +15820,16 @@ + A smooth muscle cell of the aorta. + BTO:0004577 aortic smooth muscle cell + + + + A smooth muscle cell of the aorta. + GOC:tfm + @@ -11715,8 +15849,15 @@ + A mesenchymal stem cell that is part of the bone marrow. mesenchymal stem cell of the bone marrow + + + + A mesenchymal stem cell that is part of the bone marrow. + GOC:tfm + @@ -11741,9 +15882,17 @@ - + An endothelial cell that is part of the vein. + FMA:62104 + KUPO:0001099 vein endothelial cell + + + + An endothelial cell that is part of the vein. + GOC:tfm + @@ -11751,8 +15900,16 @@ + An endothelial progenitor cell that participates in angiogenesis during development. + See CL:0002619. embryonic blood vessel endothelial progenitor cell + + + + An endothelial progenitor cell that participates in angiogenesis during development. + GOC:tfm + @@ -11777,8 +15934,15 @@ + A fibroblast of the aortic adventitia. fibroblast of the aortic adventitia + + + + A fibroblast of the aortic adventitia. + GOC:tfm + @@ -11804,8 +15968,15 @@ + A fibroblast that is part of the heart. fibroblast of cardiac tissue + + + + A fibroblast that is part of the heart. + GOC:tfm + @@ -11830,8 +16001,15 @@ + Any skin fibroblast that is part of some dermis. fibroblast of dermis + + + + Any skin fibroblast that is part of some dermis. + FBC:Autogenerated + @@ -11856,8 +16034,17 @@ + A fibroblast that is part of lung. + BTO:0000764 + CALOHA:TS-0575 fibroblast of lung + + + + A fibroblast that is part of lung. + GOC:tfm + @@ -11882,9 +16069,48 @@ - + A fibroblast of pulmonary artery. fibroblast of pulmonary artery + + + + A fibroblast of pulmonary artery. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the intestine. + intestinal epithelial cell + + + + + An epithelial cell of the intestine. + GOC:tfm + @@ -11909,8 +16135,110 @@ + A mesenchymal stem cell of adipose tissue. mesenchymal stem cell of adipose tissue + + + + A mesenchymal stem cell of adipose tissue. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + A mesenchymal stem cell of liver. + hepatic mesenchymal stem cell + + + + + A mesenchymal stem cell of liver. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + A mesenchymal stem cell of the vertebrae. + vertebral mesenchymal stem cell + + + + + A mesenchymal stem cell of the vertebrae. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A stromal cell of the pancreas. + stromal cell of pancreas + + + + + A stromal cell of the pancreas. + GOC:tfm + @@ -11936,8 +16264,15 @@ + A pericyte of the central nervous system. central nervous system pericyte + + + + A pericyte of the central nervous system. + GOC:tfm + @@ -11963,9 +16298,15 @@ - + A blood vessel endothelial cell that is part of the retina. retinal blood vessel endothelial cell + + + + A blood vessel endothelial cell that is part of the retina. + GOC:tfm + @@ -11990,8 +16331,15 @@ + A smooth muscle cell of the bachiocephalic vasculature. smooth muscle cell of the brachiocephalic vasculature + + + + A smooth muscle cell of the bachiocephalic vasculature. + GOC:tfm + @@ -12017,8 +16365,15 @@ + A vascular associated smooth muscle cell of the brain vasculature. smooth muscle cell of the brain vasculature + + + + A vascular associated smooth muscle cell of the brain vasculature. + GOC:tfm + @@ -12043,9 +16398,16 @@ - + A smooth muscle of the pulmonary artery. + BTO:0003336 smooth muscle cell of the pulmonary artery + + + + A smooth muscle of the pulmonary artery. + GOC:tfm + @@ -12070,8 +16432,15 @@ + A smooth muscle cell of the subclavian artery. smooth muscle cell of the subclavian artery + + + + A smooth muscle cell of the subclavian artery. + GOC:tfm + @@ -12096,8 +16465,15 @@ + Smooth muscle cell of the carotid artery. smooth muscle cell of the carotid artery + + + + Smooth muscle cell of the carotid artery. + GOC:tfm + @@ -12122,9 +16498,16 @@ - + Any smooth muscle cell that is part of some bronchus. + BTO:0004402 bronchial smooth muscle cell + + + + Any smooth muscle cell that is part of some bronchus. + FBC:Autogenerated + @@ -12149,8 +16532,15 @@ + A smooth muscle cell of the esophagus. smooth muscle cell of the esophagus + + + + A smooth muscle cell of the esophagus. + GOC:tfm + @@ -12175,8 +16565,15 @@ + A smooth muscle cell of the trachea. smooth muscle cell of trachea + + + + A smooth muscle cell of the trachea. + GOC:tfm + @@ -12202,8 +16599,15 @@ + A neuron of the raphe nuclei. raphe nuclei neuron + + + + A neuron of the raphe nuclei. + GOC:tfm + @@ -12229,8 +16633,15 @@ + A neuron of the ventral spinal cord. neuron of the ventral spinal cord + + + + A neuron of the ventral spinal cord. + GOC:tfm + @@ -12255,9 +16666,17 @@ - + A fibroblast of skin. + BTO:0001255 + CALOHA:TS-0935 skin fibroblast + + + + A fibroblast of skin. + GOC:tfm + @@ -12282,8 +16701,15 @@ + Any epithelial cell that is part of some lower respiratory tract epithelium. epithelial cell of lower respiratory tract + + + + Any epithelial cell that is part of some lower respiratory tract epithelium. + FBC:Autogenerated + @@ -12291,8 +16717,15 @@ + A squamous shaped endothelial cell. squamous endothelial cell + + + + A squamous shaped endothelial cell. + GOC:dos + @@ -12312,8 +16745,45 @@ + A glandular epithelial cell of the esophagus. + FMA:86548 glandular cell of esophagus + + + + A glandular epithelial cell of the esophagus. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + A glandular epithelial cell of the large intestine. + FMA:87194 + glandular cell of the large intestine + + + + + A glandular epithelial cell of the large intestine. + GOC:tfm + @@ -12333,8 +16803,17 @@ + A glandular epithelial cell that is part of the stomach. + CALOHA:TS-1284 + FMA:86554 glandular cell of stomach + + + + A glandular epithelial cell that is part of the stomach. + GOC:tfm + @@ -12359,8 +16838,16 @@ + A myocardial endocrine cell that is part of the atrium. + FMA:83389 myocardial endocrine cell of atrium + + + + A myocardial endocrine cell that is part of the atrium. + GOC:tfm + @@ -12368,8 +16855,17 @@ + A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart. + Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. cardioblast + + + + A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart. + GOC:tfm + PMID:19745164 + @@ -12384,8 +16880,17 @@ + A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. retinal progenitor cell + + + + A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. + GOC:tfm + PMID:20959166 + PMID:21148186 + @@ -12400,8 +16905,46 @@ + A neuroblast derived from a neural crest cell. neural crest derived neuroblast + + + + A neuroblast derived from a neural crest cell. + GOC:tfm + PMID:17407019 + + + + + + + + + + + + + + + + + + + + + A PP cell found in intestine. + PP cell of intestine + + + + + A PP cell found in intestine. + GOC:tfm + PMID:2420136 + PMID:728970 + @@ -12426,8 +16969,16 @@ + A CNS interneuron located in the spinal cord. + Is_a interneuron, part_of UBERON:0002240. spinal cord interneuron + + + + A CNS interneuron located in the spinal cord. + CL:CVS + @@ -12435,8 +16986,35 @@ + A ciliated epithelial cell with many cilia. multi-ciliated epithelial cell + + + + A ciliated epithelial cell with many cilia. + CL:CVS + + + + + + + + + Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation. + hepatoblast + + + + + Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation. + GOC:CVS + PMID:18356246 + PMID:20483998 + PMID:26798363 + https://orcid.org/0000-0003-1940-6740 + @@ -12444,8 +17022,16 @@ + Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized). + Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts) skeletogenic cell + + + + Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized). + GO_REF:0000034 + @@ -12466,8 +17052,15 @@ + Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. premigratory neural crest cell + + + + Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. + UBERONREF:0000002 + @@ -12475,8 +17068,15 @@ + Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells. prechondroblast + + + + Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells. + GO_REF:0000034 + @@ -12484,8 +17084,15 @@ + Any muscle cell in which the fibers are not organised into sarcomeres. non-striated muscle cell + + + + Any muscle cell in which the fibers are not organised into sarcomeres. + GOC:DOS + @@ -12493,8 +17100,15 @@ + Any hematopoietic cell that is a precursor of some other hematopoietic cell type. hematopoietic precursor cell + + + + Any hematopoietic cell that is a precursor of some other hematopoietic cell type. + GOC:dos + @@ -12532,8 +17146,17 @@ + A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + MESH:D018485 skeletal muscle fiber + + + + A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:tfm + ISBN:0323052908 + @@ -12558,8 +17181,15 @@ + A muscle cell that is part of some visceral muscle. visceral muscle cell + + + + A muscle cell that is part of some visceral muscle. + GOC:dos + @@ -12587,8 +17217,15 @@ + A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods. striated visceral muscle cell + + + + A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods. + GOC:dos + @@ -12621,8 +17258,15 @@ + A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods. transversely striated visceral muscle cell + + + + A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods. + GOC:dos + @@ -12646,8 +17290,16 @@ + A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers. + The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins. adult skeletal muscle myoblast + + + + A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers. + PMID:23303905 + @@ -12668,7 +17320,6 @@ A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration. - mesenchymal cell @@ -12696,8 +17347,43 @@ + A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves. endocardial cushion cell + + + + A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves. + PMID:18816864 + + + + + + + + + + + + + + + + + + + + + An endocrine cell that is part of the pancreas. + pancreatic endocrine cell + + + + + An endocrine cell that is part of the pancreas. + GOC:dos + @@ -12722,8 +17408,15 @@ + Any neuron that is capable of part of some visual perception. visual system neuron + + + + Any neuron that is capable of part of some visual perception. + FBC:Autogenerated + @@ -12731,9 +17424,15 @@ - + Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation. mural cell + + + + Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation. + Wiki:Mural_cell&oldid=930603194 + @@ -12759,8 +17458,15 @@ + Any vascular associated smooth muscle cell that is part of some microcirculatory vessel. microcirculation associated smooth muscle cell + + + + Any vascular associated smooth muscle cell that is part of some microcirculatory vessel. + FBC:Autogenerated + @@ -12785,8 +17491,16 @@ + A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord. sensory neuron of spinal nerve + + + + A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord. + GOC:nv + GOC:pr + @@ -12832,6 +17546,8 @@ Any cell in the compound eye, a light sensing organ composed of ommatidia. + GOC:pr + PMID:12021768 compound eye retinal cell @@ -12858,8 +17574,503 @@ + Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + PMID:10702418 retinal cell + + + + Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + GOC:pr + + + + + + + + + + + + + + + + + + + + + An enteroendocrine cell that is located in the small intestine. + enteroendocrine cell of small intestine + + + + + An enteroendocrine cell that is located in the small intestine. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A lymphocyte that resides in the lamina propria of the large intestine. + This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. + lymphocyte of large intestine lamina propria + + + + + A lymphocyte that resides in the lamina propria of the large intestine. + https://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A stromal cell found in the lamina propria of the large intestine. + stromal cell of lamina propria of large intestine + + + + + A stromal cell found in the lamina propria of the large intestine. + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A stromal cell found in the lamina propria of the small intestine. + stromal cell of lamina propria of small intestine + + + + + A stromal cell found in the lamina propria of the small intestine. + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + A mesothelial cell that is part of the small intestine. + mesothelial cell of small intestine + + + + + A mesothelial cell that is part of the small intestine. + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + A mesothelial cell that is part of the colon. + mesothelial cell of colon + + + + + A mesothelial cell that is part of the colon. + http://orcid.org/0000-0003-3440-1876 + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A macrophage that is located in the colon. + This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. + colon macrophage + + + + + A macrophage that is located in the colon. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A stromal cell found in the lamina propria of the colon. + stromal cell of lamina propria of colon + + + + + A stromal cell found in the lamina propria of the colon. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + An enteroendocrine cell that is located in the colon. + enteroendocrine cell of colon + + + + + An enteroendocrine cell that is located in the colon. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response. + This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. + lymphocyte of small intestine lamina propria + + + + + A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response. + PMID:26551552 + https://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A macrophage that is located in the anorectum. + This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. + anorectum macrophage + + + + + A macrophage that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A T cell that is located in the anorectum. + This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you. + T cell of anorectum + + + + + A T cell that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is located in the anorectum. + smooth muscle cell of anorectum + + + + + A smooth muscle cell that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A stromal cell found in the lamina propria of the anorectum. + stromal cell of anorectum lamina propria + + + + + A stromal cell found in the lamina propria of the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + + An enteroendocrine cell that is located in the anorectum. + enteroendocrine cell of anorectum + + + + + An enteroendocrine cell that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + @@ -12884,9 +18095,53 @@ - + A pericyte cell that is part of a lung. + EFO:0010669 lung pericyte + + + + A pericyte cell that is part of a lung. + https://orcid.org/0000-0003-3440-1876 + https://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell that is part of a hepatic portal vein. + EFO:0010704 + endothelial cell of hepatic portal vein + + + + + An endothelial cell that is part of a hepatic portal vein. + PMID:30348985 + https://orcid.org/0000-0003-3440-1876 + https://orcid.org/0000-0003-4183-8865 + @@ -12911,8 +18166,52 @@ + A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development. embryonic skeletal muscle fiber + + + + A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development. + PMID:32094117 + PMID:7196501 + http://orcid.org/0000-0003-2034-601X + + + + + + + + + + + + + + + + + + + + + + + + + + A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen. + hepatic portal fibroblast + + + + + A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen. + PMID:20209607 + PMID:24814904 + https://orcid.org/0000-0001-7655-4833 + @@ -12960,6 +18259,8 @@ An epithelial cell that is part_of a alveolus of lung. + MESH:D056809 + May be merged with pneumocyte in future epithelial cell of alveolus of lung @@ -13003,8 +18304,15 @@ + Any blood vessel endothelial cell that is part of some heart. cardiac blood vessel endothelial cell + + + + Any blood vessel endothelial cell that is part of some heart. + FBC:Autogenerated + @@ -13029,8 +18337,15 @@ + Any cell that is part of some His-Purkinje system. His-Purkinje system cell + + + + Any cell that is part of some His-Purkinje system. + FBC:Autogenerated + @@ -13056,9 +18371,15 @@ - + Any endothelial cell that is part of some heart. cardiac endothelial cell + + + + Any endothelial cell that is part of some heart. + FBC:Autogenerated + @@ -13085,8 +18406,15 @@ + Any photoreceptor cell that is part of some camera-type eye. camera-type eye photoreceptor cell + + + + Any photoreceptor cell that is part of some camera-type eye. + FBC:Autogenerated + @@ -13095,6 +18423,7 @@ A zygote in a plant or an animal. + MESH:D015053 zygote @@ -13122,8 +18451,15 @@ + Any glial cell that is part of some heart. cardiac glial cell + + + + Any glial cell that is part of some heart. + FBC:Autogenerated + @@ -13148,8 +18484,16 @@ + Any myoblast that develops into some cardiac muscle cell. + MESH:D032386 cardiac myoblast + + + + Any myoblast that develops into some cardiac muscle cell. + FBC:Autogenerated + @@ -13174,8 +18518,17 @@ + A neuron that has its soma in the heart. + This term is used in 3 GO terms that were created as part of the heart development focus project. cardiac neuron + + + + A neuron that has its soma in the heart. + PMID:12486170 + PMID:29265764 + @@ -13201,8 +18554,15 @@ + A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. spinal cord motor neuron + + + + A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. + GOC:nv + @@ -13227,8 +18587,16 @@ + A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites. paraxial cell + + + + A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites. + GOC:NV + PMID:11687492 + @@ -13237,8 +18605,16 @@ + A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. neural crest cell + + + + A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. + https://orcid.org/0000-0001-5208-3432 + https://orcid.org/0000-0002-9900-7880 + @@ -13346,8 +18722,16 @@ + A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses. progenitor cell + + + + A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses. + ISBN:978-1-62808-994-3 + https://doi.org/10.1016/B978-0-12-409503-8.00002-0 + @@ -13367,8 +18751,16 @@ + Any fibroblast that is part of skeletal muscle tissue. skeletal muscle fibroblast + + + + Any fibroblast that is part of skeletal muscle tissue. + PMID:28369879 + https://orcid.org/0000-0001-6164-0667 + @@ -13388,8 +18780,49 @@ + Any microvascular endothelial cell that is part of the dermis. dermal microvascular endothelial cell + + + + Any microvascular endothelial cell that is part of the dermis. + BTO:0004574 + CL:patterns/cellPartOfAnatomicalEntity + + + + + + + + + + + + + + + + + + + + + + + + + + Epithelial cell that is part of the colon epithelium. + colon epithelial cell + + + + + Epithelial cell that is part of the colon epithelium. + GOC:NV + @@ -13414,8 +18847,16 @@ + A cell that, by division or terminal differentiation, can give rise to other cell types. + Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell. precursor cell + + + + A cell that, by division or terminal differentiation, can give rise to other cell types. + GOC:dos + @@ -13440,8 +18881,15 @@ + Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain. neutrophillic cytoplasm + + + + Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain. + GOC:add + @@ -13466,8 +18914,15 @@ + Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain. acidophilic cytoplasm + + + + Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain. + GOC:add + @@ -13492,8 +18947,15 @@ + Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions. basophilic cytoplasm + + + + Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions. + GOC:tfm + @@ -13518,8 +18980,15 @@ + Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions. polychromatophilic cytoplasm + + + + Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions. + GOC:tfm + @@ -13572,7 +19041,6 @@ Any chondrocyte that is part of the tracheobronchial tree. - tracheobronchial chondrocyte @@ -13599,9 +19067,15 @@ - + A smooth muscle cell that is part of any blood vessel. blood vessel smooth muscle cell + + + + A smooth muscle cell that is part of any blood vessel. + PMID:9108778 + @@ -13626,9 +19100,116 @@ - + A smooth muscle cell that is part of the tracheobronchial tree. tracheobronchial smooth muscle cell + + + + A smooth muscle cell that is part of the tracheobronchial tree. + PMID:10853867 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes. + extrahepatic cholangiocyte + + + + + An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes. + PMID:23720296 + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid. + EFO:0010705 + endothelial cell of periportal hepatic sinusoid + + + + + An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid. + PMID:27423426 + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid. + EFO:0010706 + endothelial cell of pericentral hepatic sinusoid + + + + + An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid. + PMID:27423426 + @@ -13649,8 +19230,15 @@ + Any neuroendocrine cell that is part of some stomach. stomach neuroendocrine cell + + + + Any neuroendocrine cell that is part of some stomach. + FBC:Autogenerated + @@ -13686,9 +19274,17 @@ - + A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. lung neuroendocrine cell + + + + A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. + PMID:33355253 + doi:10.3109/01902148209069653 + doi:10.7554/eLife.78216 + @@ -13713,9 +19309,15 @@ - + Any ciliated cell that is part of some lung. lung ciliated cell + + + + Any ciliated cell that is part of some lung. + FBC:Autogenerated + @@ -13740,8 +19342,15 @@ + Any secretory cell that is part of some lung. lung secretory cell + + + + Any secretory cell that is part of some lung. + FBC:Autogenerated + @@ -13754,6 +19363,210 @@ + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the small intestine. + FMA:15050 + smooth muscle cell of small intestine + + + + + A smooth muscle cell that is part of the small intestine. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the duodenum. + FMA:15058 + smooth muscle fiber of duodenum + + + + + A smooth muscle cell that is part of the duodenum. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the large intestine. + FMA:15653 + smooth muscle cell of large intestine + + + + + A smooth muscle cell that is part of the large intestine. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the colon. + FMA:15663 + smooth muscle cell of colon + + + + + A smooth muscle cell that is part of the colon. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the sigmoid colon. + FMA:17521 + smooth muscle cell of sigmoid colon + + + + + A smooth muscle cell that is part of the sigmoid colon. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle cell that is part of the rectum. + FMA:17522 + smooth muscle cell of rectum + + + + + A smooth muscle cell that is part of the rectum. + GOC:tfm + + + + @@ -13775,8 +19588,16 @@ + A fibroblast that is part of the areolar connective tissue. + FMA:261279 fibroblast of areolar connective tissue + + + + A fibroblast that is part of the areolar connective tissue. + GOC:tfm + @@ -13802,8 +19623,16 @@ + A fibroblast that is part of the tunica adventitia of artery. + FMA:261285 fibroblast of tunica adventitia of artery + + + + A fibroblast that is part of the tunica adventitia of artery. + GOC:tfm + @@ -13834,8 +19663,16 @@ + A fibroblast that is part of the dense regular elastic tissue. + FMA:261287 fibroblast of dense regular elastic tissue + + + + A fibroblast that is part of the dense regular elastic tissue. + GOC:tfm + @@ -13850,9 +19687,16 @@ - + An adipocyte that is part of the epicardial fat. + FMA:261293 epicardial adipocyte + + + + An adipocyte that is part of the epicardial fat. + GOC:tfm + @@ -13877,8 +19721,16 @@ + An adipocyte that is part of the epicardial fat of right ventricle. + FMA:261297 adipocyte of epicardial fat of right ventricle + + + + An adipocyte that is part of the epicardial fat of right ventricle. + GOC:tfm + @@ -13903,8 +19755,16 @@ + An adipocyte that is part of the epicardial fat of left ventricle. + FMA:261300 adipocyte of epicardial fat of left ventricle + + + + An adipocyte that is part of the epicardial fat of left ventricle. + GOC:tfm + @@ -13929,9 +19789,16 @@ - + A serous secreting cell that is part of the epithelium of trachea. + FMA:263078 serous cell of epithelium of trachea + + + + A serous secreting cell that is part of the epithelium of trachea. + GOC:tfm + @@ -13956,9 +19823,16 @@ - + A serous secreting cell that is part of the epithelium of bronchus. + FMA:263080 serous cell of epithelium of bronchus + + + + A serous secreting cell that is part of the epithelium of bronchus. + GOC:tfm + @@ -13984,8 +19858,16 @@ + A serous secreting cell that is part of the epithelium of terminal bronchiole. + FMA:263082 serous cell of epithelium of terminal bronchiole + + + + A serous secreting cell that is part of the epithelium of terminal bronchiole. + GOC:tfm + @@ -14011,8 +19893,16 @@ + A transitional myocyte that is part of the interatrial septum. + FMA:263152 transitional myocyte of interatrial septum + + + + A transitional myocyte that is part of the interatrial septum. + GOC:tfm + @@ -14038,8 +19928,16 @@ + A transitional myocyte that is part of the interventricular septum. + FMA:263154 transitional myocyte of interventricular septum + + + + A transitional myocyte that is part of the interventricular septum. + GOC:tfm + @@ -14065,8 +19963,53 @@ + A Purkinje myocyte that is part of the interventricular septum. + FMA:263182 Purkinje myocyte of interventricular septum + + + + A Purkinje myocyte that is part of the interventricular septum. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates. + BTO:000125 + FMA:62911 + endothelial cell of hepatic sinusoid + + + + + An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates. + GOC:tfm + PMID:3926620 + @@ -14092,8 +20035,17 @@ + A muscle cell that is part of the sinoatrial node. + FMA:67102 myocyte of sinoatrial node + + + + A muscle cell that is part of the sinoatrial node. + FMA:67102 + GOC:tfm + @@ -14120,8 +20072,17 @@ + A muscle cell that is part of the atrioventricular node. + FMA:67106 myocyte of atrioventricular node + + + + A muscle cell that is part of the atrioventricular node. + FMA:67106 + GOC:tfm + @@ -14146,9 +20107,17 @@ - + An endothelial cell that is part of the arteriole. + FMA:67760 + KUPO:0001097 endothelial cell of arteriole + + + + An endothelial cell that is part of the arteriole. + GOC:tfm + @@ -14173,9 +20142,18 @@ - + A blood vessel endothelial cell that is part of an arterial endothelium. + BTO:0004758 + FMA:67761 + KUPO:0001095 endothelial cell of artery + + + + A blood vessel endothelial cell that is part of an arterial endothelium. + GOC:tfm + @@ -14200,9 +20178,50 @@ - + An endothelial cell that is part of the venule. + FMA:67762 endothelial cell of venule + + + + An endothelial cell that is part of the venule. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell that is part of the gallbladder. + FMA:67780 + epithelial cell of gallbladder + + + + + An epithelial cell that is part of the gallbladder. + GOC:tfm + @@ -14227,8 +20246,16 @@ + A somatic stem cell that is part of the epidermis. + FMA:70541 stem cell of epidermis + + + + A somatic stem cell that is part of the epidermis. + GOC:tfm + @@ -14253,8 +20280,16 @@ + A smooth muscle cell that is part of the ciliary body. + FMA:70610 ciliary muscle cell + + + + A smooth muscle cell that is part of the ciliary body. + GOC:tfm + @@ -14279,8 +20314,16 @@ + A mesothelial cell that is part of the anterior chamber of eyeball. + FMA:70615 mesothelial cell of anterior chamber of eye + + + + A mesothelial cell that is part of the anterior chamber of eyeball. + GOC:tfm + @@ -14305,8 +20348,16 @@ + A mesothelial cell that is part of the parietal peritoneum. + FMA:72142 mesothelial cell of parietal peritoneum + + + + A mesothelial cell that is part of the parietal peritoneum. + GOC:tfm + @@ -14331,9 +20382,16 @@ - + A mesothelial cell that is part of the visceral peritoneum. + FMA:72143 mesothelial cell of visceral peritoneum + + + + A mesothelial cell that is part of the visceral peritoneum. + GOC:tfm + @@ -14353,8 +20411,16 @@ + A transitional myocyte that is part of the sinoatrial node. + FMA:83384 transitional myocyte of sinoatrial node + + + + A transitional myocyte that is part of the sinoatrial node. + GOC:tfm + @@ -14374,8 +20440,16 @@ + A Purkinje myocyte that is part of the atrioventricular node. + FMA:83386 Purkinje myocyte of atrioventricular node + + + + A Purkinje myocyte that is part of the atrioventricular node. + GOC:tfm + @@ -14401,8 +20475,79 @@ + A myocardial endocrine cell that is part of the interventricular septum. + FMA:83390 myocardial endocrine cell of interventricular septum + + + + A myocardial endocrine cell that is part of the interventricular septum. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. + FMA:86481 + cholangiocyte + + + + + An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. + GOC:tfm + PMID:16550043 + PMID:18356246 + @@ -14427,8 +20572,16 @@ + A mesothelial cell that is part of the peritoneum. + FMA:86736 mesothelial cell of peritoneum + + + + A mesothelial cell that is part of the peritoneum. + GOC:tfm + @@ -14453,8 +20606,16 @@ + A mesothelial cell that is part of the pleura. + FMA:86737 mesothelial cell of pleura + + + + A mesothelial cell that is part of the pleura. + GOC:tfm + @@ -14479,8 +20640,16 @@ + A mesothelial cell that is part of the parietal pleura. + FMA:86738 mesothelial cell of parietal pleura + + + + A mesothelial cell that is part of the parietal pleura. + GOC:tfm + @@ -14505,9 +20674,78 @@ - + A mesothelial cell that is part of the visceral pleura. + FMA:86739 mesothelial cell of visceral pleura + + + + A mesothelial cell that is part of the visceral pleura. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelial cell of the exocrine pancreas. + FMA:70986 + epithelial cell of exocrine pancreas + + + + + An epithelial cell of the exocrine pancreas. + GOC:tfm + + + + + + + + + + + + + + + + + + + + + The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract. + intestinal enteroendocrine cell + + + + + The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract. + MP:0010802 + @@ -14532,8 +20770,15 @@ + Any endothelial cell of vascular tree that is part of some lung. lung endothelial cell + + + + Any endothelial cell of vascular tree that is part of some lung. + FBC:Autogenerated + @@ -14558,9 +20803,51 @@ - + Any endothelial cell of vascular tree that is part of some pulmonary artery. + BTO:0001141 pulmonary artery endothelial cell + + + + Any endothelial cell of vascular tree that is part of some pulmonary artery. + FBC:Autogenerated + + + + + + + + + + + + + + + + + + + + + + + + + + A vascular endothelial cell found in colon blood vessels. + CALOHA:TS-2397 + colon endothelial cell + + + + + A vascular endothelial cell found in colon blood vessels. + NPX:PDR + https://orcid.org/0000-0001-5208-3432 + @@ -14586,8 +20873,223 @@ + Squamous cell of oral epithelium. + CALOHA:TS-1252 oral mucosa squamous cell + + + + Squamous cell of oral epithelium. + NPX:PDR + + + + + + + + + + + + + + + + + + + + + Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells. + CALOHA:TS-1274 + colon glandular cell + + + + + Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells. + NPX:PDR + + + + + + + + + + + + + + + + + + + + + + + + + + Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell. + CALOHA:TS-1275 + duodenum glandular cell + + + + + Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell. + NPX:PDR + + + + + + + + + + + + + + + + + + + + + + + + + + + Glandular cell of gallbladder epithelium. + CALOHA:TS-1278 + gallbladder glandular cell + + + + + Glandular cell of gallbladder epithelium. + NPX:PDR + + + + + + + + + + + + + + + + + + + + + + + + + + Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells. + CALOHA:TS-1281 + rectum glandular cell + + + + + Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells. + NPX:PDR + + + + + + + + + + + + + + + + + + + + + + + + + + + A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) . + CALOHA:TS-1286 + FMA:86928 + small intestine glandular cell + + + + + A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) . + NCI_Thesaurus:Small_Intestinal_Glandular_Cell + NPX:PDR + + + + + + + + + + + + + + + + + + + + + + + + + + + + Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts. + BTO:0000028 + CALOHA:TS-1242 + pancreas exocrine glandular cell + + + + + Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts. + HPA:HPA + NPX:PDR + @@ -14612,8 +21114,17 @@ + Circulating macrophages and tissue macrophages (alveolar macrophages) of lung. + CALOHA:TS-0576 lung macrophage + + + + Circulating macrophages and tissue macrophages (alveolar macrophages) of lung. + HPA:HPA + NPX:PDR + @@ -14638,8 +21149,16 @@ + Fibroblast from muscle organ. + CALOHA:TS-0643 muscle fibroblast + + + + Fibroblast from muscle organ. + NPX:PDR + @@ -14665,8 +21184,16 @@ + Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes. + CALOHA:TS-2109 bone marrow hematopoietic cell + + + + Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes. + NPX:PDR + @@ -14692,8 +21219,15 @@ + A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood. peripheral blood mononuclear cell + + + + A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood. + GOC:TermGenie + @@ -14718,8 +21252,15 @@ + Any blood vessel endothelial cell that is part of a microvascular endothelium. microvascular endothelial cell + + + + Any blood vessel endothelial cell that is part of a microvascular endothelium. + GOC:TermGenie + @@ -14744,8 +21285,15 @@ + Any blood vessel endothelial cell that is part of a dermis. dermis blood vessel endothelial cell + + + + Any blood vessel endothelial cell that is part of a dermis. + GOC:TermGenie + @@ -14770,8 +21318,15 @@ + Any skin fibroblast that is part of a skin of abdomen. fibroblast of skin of abdomen + + + + Any skin fibroblast that is part of a skin of abdomen. + GOC:TermGenie + @@ -14791,8 +21346,15 @@ + Any lung endothelial cell that is part of a microvascular endothelium. lung microvascular endothelial cell + + + + Any lung endothelial cell that is part of a microvascular endothelium. + GOC:TermGenie + @@ -14817,8 +21379,15 @@ + Any photoreceptor cell that is part of a compound eye. compound eye photoreceptor cell + + + + Any photoreceptor cell that is part of a compound eye. + GOC:TermGenie + @@ -14843,8 +21412,15 @@ + Any native cell that is part of a inner cell mass. inner cell mass cell + + + + Any native cell that is part of a inner cell mass. + GOC:TermGenie + @@ -14869,8 +21445,15 @@ + Any native cell that is part of a cardiac septum. cardiac septum cell + + + + Any native cell that is part of a cardiac septum. + GOC:TermGenie + @@ -14895,8 +21478,15 @@ + Any neuron that is part of a central nervous system. central nervous system neuron + + + + Any neuron that is part of a central nervous system. + GOC:TermGenie + @@ -14921,9 +21511,17 @@ - + A neuron that is part of a peripheral nervous system. + FMA:84664 peripheral nervous system neuron + + + + A neuron that is part of a peripheral nervous system. + GOC:TermGenie + ISBN:0721662544 + @@ -14948,8 +21546,15 @@ + Any fibroblast that is part of a embryo. embryonic fibroblast + + + + Any fibroblast that is part of a embryo. + GOC:TermGenie + @@ -14974,8 +21579,15 @@ + Any pericyte cell that is part of a brain. brain pericyte + + + + Any pericyte cell that is part of a brain. + GOC:TermGenie + @@ -15001,8 +21613,15 @@ + Any microvascular endothelial cell that is part of a brain. brain microvascular endothelial cell + + + + Any microvascular endothelial cell that is part of a brain. + GOC:TermGenie + @@ -15027,8 +21646,15 @@ + Any cardiac muscle cell that is part of a cardiac ventricle. ventricular cardiac muscle cell + + + + Any cardiac muscle cell that is part of a cardiac ventricle. + GOC:TermGenie + @@ -15054,8 +21680,116 @@ + Any motor neuron that is part of a brainstem. brainstem motor neuron + + + + Any motor neuron that is part of a brainstem. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + Any fibroblast that is part of a spleen. + splenic fibroblast + + + + + Any fibroblast that is part of a spleen. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + Any endothelial cell that is part of a spleen. + http://www.sciencellonline.com/site/productInformation.php?keyword=5500 + splenic endothelial cell + + + + + Any endothelial cell that is part of a spleen. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + Any dendritic cell that is part of a liver. + http://www.jleukbio.org/content/66/2/322.abstract + liver dendritic cell + + + + + Any dendritic cell that is part of a liver. + GOC:TermGenie + @@ -15080,8 +21814,16 @@ + Any fibroblast that is part of a female gonad. + http://www.sciencellonline.com/site/productInformation.php?keyword=7330 ovarian fibroblast + + + + Any fibroblast that is part of a female gonad. + GOC:TermGenie + @@ -15106,8 +21848,16 @@ + Any epithelial cell that is part of a female gonad. + http://www.sciencellonline.com/site/productInformation.php?keyword=7310 ovarian surface epithelial cell + + + + Any epithelial cell that is part of a female gonad. + GOC:TermGenie + @@ -15132,9 +21882,16 @@ - + Any fibroblast that is part of a cardiac ventricle. + http://www.sciencellonline.com/site/productInformation.php?keyword=6310 cardiac ventricle fibroblast + + + + Any fibroblast that is part of a cardiac ventricle. + GOC:TermGenie + @@ -15159,9 +21916,16 @@ - + Any fibroblast that is part of a cardiac atrium. + http://www.sciencellonline.com/site/productInformation.php?keyword=6320 cardiac atrium fibroblast + + + + Any fibroblast that is part of a cardiac atrium. + GOC:TermGenie + @@ -15186,8 +21950,50 @@ + Any fibroblast that is part of a pericardium. + http://www.sciencellonline.com/site/productInformation.php?keyword=6430 pericardium fibroblast + + + + Any fibroblast that is part of a pericardium. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + Any fibroblast that is part of a gallbladder. + http://www.sciencellonline.com/site/productInformation.php?keyword=5430 + gallbladder fibroblast + + + + + Any fibroblast that is part of a gallbladder. + GOC:TermGenie + @@ -15212,8 +22018,16 @@ + Any fibroblast that is part of a optic choroid. + http://www.sciencellonline.com/site/productInformation.php?keyword=6620 optic choroid fibroblast + + + + Any fibroblast that is part of a optic choroid. + GOC:TermGenie + @@ -15239,8 +22053,16 @@ + Any microvascular endothelial cell that is part of a adipose tissue. + http://www.sciencellonline.com/site/productInformation.php?keyword=7200 adipose microvascular endothelial cell + + + + Any microvascular endothelial cell that is part of a adipose tissue. + GOC:TermGenie + @@ -15265,8 +22087,49 @@ + Any migratory neural crest cell that is part of a cardiac neural crest. migratory cardiac neural crest cell + + + + Any migratory neural crest cell that is part of a cardiac neural crest. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + Any leukocyte that is part of a spleen. + Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology. + splenocyte + + + + + Any leukocyte that is part of a spleen. + GOC:TermGenie + @@ -15291,8 +22154,15 @@ + Any mesenchymal stem cell of adipose tissue that is part of an abdomen. mesenchymal stem cell of abdominal adipose tissue + + + + Any mesenchymal stem cell of adipose tissue that is part of an abdomen. + GOC:TermGenie + @@ -15317,8 +22187,15 @@ + Any fibroblast of lung that is part of a bronchus. bronchus fibroblast of lung + + + + Any fibroblast of lung that is part of a bronchus. + GOC:TermGenie + @@ -15344,8 +22221,16 @@ + A ciliated epithelial cell of the esophagus. ciliated epithelial cell of esophagus + + + + A ciliated epithelial cell of the esophagus. + GOC:CellBLAST + PMID:29802404 + @@ -15365,8 +22250,16 @@ + Peripheral sensory neuron. peripheral sensory neuron + + + + Peripheral sensory neuron. + GOC:CellBLAST + PMID:30096314 + @@ -15391,9 +22284,15 @@ - + A cell that is part of the brain vasculature. brain vascular cell + + + + A cell that is part of the brain vasculature. + DOI:10.1101/2022.10.12.511898 + @@ -15419,9 +22318,15 @@ - + A GABAergic inhibitory neuron that is derived from the midbrain. midbrain-derived inhibitory neuron + + + + A GABAergic inhibitory neuron that is derived from the midbrain. + DOI:10.1101/2022.10.12.511898 + @@ -15446,8 +22351,15 @@ + A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli. somatosensory neuron + + + + A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli. + PMID:22865660 + @@ -15490,9 +22402,35 @@ - + + + + + + + A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets. + A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7. alveolar type 1 fibroblast cell + + + + A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets. + PMID:22268140 + PMID:26706109 + PMID:28886382 + PMID:29489752 + PMID:30675802 + PMID:33624948 + PMID:33707239 + PMID:9074756 + + + + + A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7. + https://doi.org/10.5281/zenodo.11165918 + @@ -15507,9 +22445,33 @@ - + + + + + + + A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia. + A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85. alveolar adventitial fibroblast + + + + A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia. + PMID:26706109 + PMID:28886382 + PMID:29752282 + PMID:30675802 + PMID:33208946 + PMID:33624948 + + + + + A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85. + https://doi.org/10.5281/zenodo.11165918 + @@ -15529,8 +22491,15 @@ + A lymphocyte located in blood. blood lymphocyte + + + + A lymphocyte located in blood. + + @@ -15555,8 +22524,15 @@ + Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. "Interstitial cell" is a morphological term and refers to a variety of cells with differing origins and phenotypes. interstitial cell + + + + Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. "Interstitial cell" is a morphological term and refers to a variety of cells with differing origins and phenotypes. + PMID:24987007 + @@ -15581,8 +22557,51 @@ + A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium. respiratory ciliated cell + + + + A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium. + PMID:18757316 + PMID:21364219 + + + + + + + + + + + + + + + + + + + + + + + + + + + A(n) serous secreting cell that is part of a(n) bronchus submucosal gland. + serous secreting cell of bronchus submucosal gland + + + + + A(n) serous secreting cell that is part of a(n) bronchus submucosal gland. + PMID:5487122 + PMID:9651178 + @@ -15607,9 +22626,15 @@ - + A(n) vein endothelial cell that is part of a(n) respiratory system. vein endothelial cell of respiratory system + + + + A(n) vein endothelial cell that is part of a(n) respiratory system. + PMID:34030460 + @@ -15634,9 +22659,16 @@ - + A smooth muscle cell that is part of a bronchiole. bronchiolar smooth muscle cell + + + + A smooth muscle cell that is part of a bronchiole. + ISBN:9781260462982 + PMID:15347627 + @@ -15662,9 +22694,123 @@ - + A megakaryocyte that is resident in the lung connective tissue. lung megakaryocyte + + + + A megakaryocyte that is resident in the lung connective tissue. + PMID:33351116 + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucus secreting cell that is part of a submucosal gland of the trachea. + mucus secreting cell of trachea gland + + + + + A mucus secreting cell that is part of a submucosal gland of the trachea. + PMID:18931053 + PMID:29656943 + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucus secreting cell of a submucosal gland of the bronchus. + mucus secreting cell of bronchus submucosal gland + + + + + A mucus secreting cell of a submucosal gland of the bronchus. + PMID:19965983 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucus secreting cell of a submucosal gland of the tracheobronchial tree. + mucus secreting cell of tracheobronchial tree submucosal gland + + + + + A mucus secreting cell of a submucosal gland of the tracheobronchial tree. + PMID:30864819 + @@ -15678,9 +22824,28 @@ - + + + + + + + An alveolar macrophage that expresses CCL3. + A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67. CCL3-positive alveolar macrophage + + + + An alveolar macrophage that expresses CCL3. + PMID:37291214 + + + + + A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67. + https://doi.org/10.5281/zenodo.11165918 + @@ -15688,9 +22853,28 @@ - + + + + + + + An alveolar macrophage that expresses metallothionein. + A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41. metallothionein-positive alveolar macrophage + + + + An alveolar macrophage that expresses metallothionein. + PMID:37291214 + + + + + A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41. + https://doi.org/10.5281/zenodo.11165918 + @@ -15715,8 +22899,49 @@ + A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics. perivascular cell + + + + A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics. + PMID:24928499 + PMID:27889329 + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelial cell that is part of a central vein of liver. + endothelial cell of central vein of liver + + + + + An endothelial cell that is part of a central vein of liver. + PMID:28287163 + @@ -15729,11 +22954,11 @@ - + - + @@ -15753,11 +22978,11 @@ - + - + @@ -15777,11 +23002,11 @@ - + - + @@ -15801,11 +23026,11 @@ - + - + @@ -15825,11 +23050,11 @@ - + - + @@ -15849,19 +23074,19 @@ - + - + - + - + @@ -15876,8 +23101,15 @@ + Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity. fetal pre-type II pulmonary alveolar epithelial cell + + + + Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity. + PMID:1316350 + @@ -15902,8 +23134,15 @@ + Any mesenchymal stem cell of adipose tissue that is part of an orbital region. mesenchymal stem cell of orbital adipose tissue + + + + Any mesenchymal stem cell of adipose tissue that is part of an orbital region. + + @@ -15955,8 +23194,17 @@ + The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. vacuole inheritance + + + + The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. + GOC:mcc + PMID:10873824 + PMID:14616069 + @@ -15982,8 +23230,16 @@ + The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. mitotic sister chromatid segregation + + + + The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. + GOC:ai + GOC:jl + @@ -16008,8 +23264,15 @@ + The lipid bilayer surrounding any of the compartments of the Golgi apparatus. Golgi membrane + + + + The lipid bilayer surrounding any of the compartments of the Golgi apparatus. + GOC:mah + @@ -16035,8 +23298,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. microtubule cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. + GOC:mah + @@ -16061,8 +23331,16 @@ + A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. nuclear chromosome + + + + A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. + GOC:dph + GOC:mah + @@ -16087,8 +23365,48 @@ + The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. polysaccharide biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + polysaccharide catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + PMID:33139480 + @@ -16125,8 +23443,18 @@ + Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. + Wikipedia:Mitosis + Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. mitotic cell cycle + + + + Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. + GOC:mah + ISBN:0815316194 + @@ -16151,8 +23479,15 @@ + The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. nuclear division + + + + The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. + GOC:mah + @@ -16177,8 +23512,16 @@ + A ribosome contained within a subcellular membrane-bounded organelle. organellar ribosome + + + + A ribosome contained within a subcellular membrane-bounded organelle. + GOC:mah + GOC:mcc + @@ -16186,8 +23529,15 @@ + A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. lytic vacuole + + + + A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. + GOC:krc + @@ -16213,8 +23563,15 @@ + The joining of 2 or more lipid bilayer membranes that surround the nucleus. nuclear membrane fusion + + + + The joining of 2 or more lipid bilayer membranes that surround the nucleus. + GOC:elh + @@ -16246,8 +23603,16 @@ + The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. + Wikipedia:Karyogamy karyogamy + + + + The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. + GOC:elh + @@ -16267,8 +23632,16 @@ + The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. syncytium formation by plasma membrane fusion + + + + The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. + GOC:mtg_muscle + GOC:tb + @@ -16282,8 +23655,18 @@ + The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. + NIF_Subcellular:sao1615953555 + Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. chromatin + + + + The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. + GOC:elh + PMID:20404130 + @@ -16291,8 +23674,17 @@ + A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. + NIF_Subcellular:sao445485807 + Wikipedia:Euchromatin euchromatin + + + + A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. + PMID:32017156 + @@ -16300,8 +23692,17 @@ + A compact and highly condensed form of chromatin that is refractory to transcription. + NIF_Subcellular:sao581845896 + Wikipedia:Heterochromatin heterochromatin + + + + A compact and highly condensed form of chromatin that is refractory to transcription. + PMID:32017156 + @@ -16310,8 +23711,16 @@ + The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. sister chromatid segregation + + + + The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. + GOC:ai + GOC:elh + @@ -16336,8 +23745,18 @@ + The developmental process in which the size or shape of a cell is generated and organized. cell morphogenesis + + + + The developmental process in which the size or shape of a cell is generated and organized. + GOC:clt + GOC:dph + GOC:go_curators + GOC:tb + @@ -16362,8 +23781,17 @@ + The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). skeletal system development + + + + The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). + GOC:dph + GOC:jid + GOC:tb + @@ -16388,8 +23816,18 @@ + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + Wikipedia:Ossification + Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. ossification + + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:mtg_mpo + PMID:17572649 + @@ -16423,8 +23861,19 @@ + A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. + Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. action potential + + + + A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. + GOC:dph + GOC:go_curators + GOC:tb + ISBN:978-0-07-139011-8 + @@ -16455,8 +23904,16 @@ + Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. + Wikipedia:Angiogenesis angiogenesis + + + + Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. + ISBN:0878932453 + @@ -16464,8 +23921,18 @@ + Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. + Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. cilium or flagellum-dependent cell motility + + + + Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. + GOC:cilia + GOC:hjd + GOC:krc + @@ -16509,8 +23976,15 @@ + The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. oocyte growth + + + + The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. + https://www.ncbi.nlm.nih.gov/books/NBK279054/ + @@ -16554,8 +24028,17 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. + Wikipedia:Oocyte_maturation oocyte maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. + GOC:devbiol + https://www.ncbi.nlm.nih.gov/books/NBK279054/ + @@ -16581,8 +24064,15 @@ + Any process that modulates the frequency, rate, extent or direction of cell growth. regulation of cell growth + + + + Any process that modulates the frequency, rate, extent or direction of cell growth. + GOC:go_curators + @@ -16607,8 +24097,15 @@ + Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time. regulation of cell growth by extracellular stimulus + + + + Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time. + GOC:dph + @@ -16639,8 +24136,16 @@ + The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. blood vessel development + + + + The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. + GOC:hjd + UBERON:0001981 + @@ -16665,8 +24170,15 @@ + The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. branching involved in blood vessel morphogenesis + + + + The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. + GOC:dph + @@ -16697,8 +24209,16 @@ + The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. + Wikipedia:Vasculogenesis vasculogenesis + + + + The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. + PMID:8999798 + @@ -16718,8 +24238,15 @@ + A process that results in a parallel arrangement of microtubules. microtubule bundle formation + + + + A process that results in a parallel arrangement of microtubules. + GOC:dph + @@ -16750,8 +24277,56 @@ + The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. + Wikipedia:Eye_development eye development + + + + The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. + GOC:jid + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. + urogenital system development + + + + + The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. + GOC:go_curators + @@ -16759,8 +24334,16 @@ + A homeostatic process in which an organism modulates its internal body temperature. + Wikipedia:Thermoregulation temperature homeostasis + + + + A homeostatic process in which an organism modulates its internal body temperature. + GOC:jl + @@ -16769,8 +24352,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. + Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. response to hypoxia + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. + GOC:hjd + @@ -16778,8 +24369,16 @@ + Cell migration that is accomplished by extension and retraction of a pseudopodium. + Note that this term refers to a mode of migration rather than to any particular cell type. ameboidal-type cell migration + + + + Cell migration that is accomplished by extension and retraction of a pseudopodium. + GOC:dph + @@ -16810,8 +24409,16 @@ + The nucleus of the female germ cell, a reproductive cell in females. female germ cell nucleus + + + + The nucleus of the female germ cell, a reproductive cell in females. + CL:0000021 + GOC:hjd + @@ -16842,8 +24449,50 @@ + Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). formation of translation initiation ternary complex + + + + Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). + GOC:hjd + + + + + + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of glucose within a cell. + intracellular glucose homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of glucose within a cell. + GOC:dph + GOC:go_curators + GOC:tb + @@ -16852,8 +24501,15 @@ + The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. gastric acid secretion + + + + The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:hjd + @@ -16873,8 +24529,16 @@ + The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. embryonic development via the syncytial blastoderm + + + + The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. + GOC:go_curators + GOC:mtg_sensu + @@ -16894,8 +24558,16 @@ + The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. in utero embryonic development + + + + The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. + GOC:go_curators + GOC:mtg_sensu + @@ -16926,8 +24598,15 @@ + The formation of the ectoderm, mesoderm and endoderm during gastrulation. formation of primary germ layer + + + + The formation of the ectoderm, mesoderm and endoderm during gastrulation. + GOC:go_curators + @@ -16958,8 +24637,15 @@ + The formation of ectoderm during gastrulation. ectoderm formation + + + + The formation of ectoderm during gastrulation. + GOC:go_curators + @@ -16990,8 +24676,15 @@ + The formation of the endoderm during gastrulation. endoderm formation + + + + The formation of the endoderm during gastrulation. + GOC:go_curators + @@ -17022,8 +24715,15 @@ + The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. mesoderm formation + + + + The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:go_curators + @@ -17054,8 +24754,15 @@ + The initial developmental process that will lead to the formation of an eye. lens placode formation + + + + The initial developmental process that will lead to the formation of an eye. + GOC:dph + @@ -17098,8 +24805,16 @@ + The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. compound eye morphogenesis + + + + The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. + GOC:dph + GOC:mtg_sensu + @@ -17130,8 +24845,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. compound eye photoreceptor cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. + GOC:go_curators + @@ -17162,8 +24884,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. eye photoreceptor cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. + GOC:go_curators + @@ -17194,8 +24923,18 @@ + The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. neural crest cell migration + + + + The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. + GOC:ascb_2009 + GOC:dph + GOC:tb + ISBN:0878932437 + @@ -17234,8 +24973,16 @@ + The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. + Wikipedia:Somitogenesis somitogenesis + + + + The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. + ISBN:0721662544 + @@ -17244,8 +24991,15 @@ + The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. morphogenesis of a branching structure + + + + The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. + ISBN:0721662544 + @@ -17276,8 +25030,18 @@ + The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. + Wikipedia:Neural_development#Neuron_migration + Wikipedia:Neuron_migration neuron migration + + + + The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. + CL:0000540 + GOC:go_curators + @@ -17308,8 +25072,17 @@ + The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell. establishment of lymphocyte polarity + + + + The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell. + GOC:mgi_curators + PMID:11244041 + PMID:12615889 + @@ -17340,8 +25113,17 @@ + The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. establishment of T cell polarity + + + + The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. + GOC:mgi_curators + PMID:11244041 + PMID:12615889 + @@ -17366,8 +25148,16 @@ + The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. myeloid dendritic cell activation + + + + The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + GOC:mgi_curators + ISBN:0781735149 + @@ -17388,8 +25178,15 @@ + A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell. cell activation + + + + A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell. + GOC:mgi_curators + @@ -17427,8 +25224,17 @@ + The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. + Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. leukocyte homeostasis + + + + The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. + GOC:add + ISBN:0781735149 + @@ -17457,8 +25263,16 @@ + The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus. T cell homeostatic proliferation + + + + The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus. + GOC:mgi_curators + ISBN:0781735149 + @@ -17467,8 +25281,17 @@ + The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. cytokine production + + + + The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:add + ISBN:0781735149 + @@ -17546,8 +25369,16 @@ + Any process that modulates the frequency, rate, or extent of production of a cytokine. regulation of cytokine production + + + + Any process that modulates the frequency, rate, or extent of production of a cytokine. + GOC:add + ISBN:0781735149 + @@ -17574,8 +25405,16 @@ + Any process that stops, prevents, or reduces the rate of production of a cytokine. negative regulation of cytokine production + + + + Any process that stops, prevents, or reduces the rate of production of a cytokine. + GOC:add + ISBN:0781735149 + @@ -17602,8 +25441,16 @@ + Any process that activates or increases the frequency, rate or extent of production of a cytokine. positive regulation of cytokine production + + + + Any process that activates or increases the frequency, rate or extent of production of a cytokine. + GOC:add + ISBN:0781735149 + @@ -17623,8 +25470,17 @@ + The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. serotonin secretion + + + + The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. + GOC:ef + ISBN:0198506732 + ISBN:0781735149 + @@ -17667,8 +25523,18 @@ + The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. blastocyst development + + + + The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17699,8 +25565,18 @@ + The initial formation of a blastocyst from a solid ball of cells known as a morula. + See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. blastocyst formation + + + + The initial formation of a blastocyst from a solid ball of cells known as a morula. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17731,8 +25607,18 @@ + The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. inner cell mass cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17763,8 +25649,18 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. trophectodermal cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17796,8 +25692,18 @@ + The morphogenesis of trophectoderm cells. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. trophectodermal cellular morphogenesis + + + + The morphogenesis of trophectoderm cells. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17828,8 +25734,18 @@ + An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. blastocyst growth + + + + An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17860,8 +25776,19 @@ + The proliferation of cells in the inner cell mass. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. inner cell mass cell proliferation + + + + The proliferation of cells in the inner cell mass. + GOC:dph + GOC:isa_complete + ISBN:0124020607 + ISBN:0198542771 + @@ -17892,8 +25819,18 @@ + The proliferation of cells in the trophectoderm. + See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. trophectodermal cell proliferation + + + + The proliferation of cells in the trophectoderm. + GOC:dph + ISBN:0124020607 + ISBN:0198542771 + @@ -17922,8 +25859,16 @@ + A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. epithelial to mesenchymal transition + + + + A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. + GOC:dph + PMID:14701881 + @@ -17937,8 +25882,16 @@ + The morphogenesis of an embryonic epithelium into a tube-shaped structure. embryonic epithelial tube formation + + + + The morphogenesis of an embryonic epithelium into a tube-shaped structure. + GOC:dph + ISBN:0824072820 + @@ -17969,8 +25922,16 @@ + The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. neural plate morphogenesis + + + + The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. + GOC:dph + ISBN:0878932437 + @@ -18001,8 +25962,18 @@ + The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. neural plate development + + + + The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. + GOC:dph + GOC:ef + ISBN:0878932437 + ISBN:0878932585 + @@ -18033,8 +26004,17 @@ + The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + Wikipedia:Neurulation neural tube formation + + + + The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + GOC:dph + ISBN:0878932437 + @@ -18067,8 +26047,16 @@ + The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. neural fold formation + + + + The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. + GOC:dph + ISBN:0878932437 + @@ -18093,8 +26081,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. + defined as response to Saccharomycotina (true yeasts). This excludes fission yeast. response to yeast + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. + PMID:14707091 + @@ -18125,8 +26121,15 @@ + The progression of an endothelial cell over time, from its formation to the mature structure. endothelial cell development + + + + The progression of an endothelial cell over time, from its formation to the mature structure. + GOC:dph + @@ -18157,8 +26160,57 @@ + The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. endothelial cell morphogenesis + + + + The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. + GOC:ascb_2009 + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. + liver development + + + + + The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. + GOC:add + ISBN:068340007X + @@ -18172,8 +26224,16 @@ + A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. tissue homeostasis + + + + A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. + GOC:add + GOC:isa_complete + @@ -18198,8 +26258,16 @@ + The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. endothelial cell proliferation + + + + The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. + GOC:add + ISBN:0781735149 + @@ -18224,8 +26292,15 @@ + Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. regulation of endothelial cell proliferation + + + + Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. + GOC:add + @@ -18251,8 +26326,15 @@ + Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. negative regulation of endothelial cell proliferation + + + + Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. + GOC:add + @@ -18278,8 +26360,15 @@ + Any process that activates or increases the rate or extent of endothelial cell proliferation. positive regulation of endothelial cell proliferation + + + + Any process that activates or increases the rate or extent of endothelial cell proliferation. + GOC:add + @@ -18310,8 +26399,16 @@ + The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. vasculature development + + + + The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. + GOC:dph + UBERON:0002409 + @@ -18342,8 +26439,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. blood vessel maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. + GOC:dph + @@ -18351,8 +26455,17 @@ + Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. + Wikipedia:Intramembranous_ossification + An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. intramembranous ossification + + + + Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. + ISBN:0878932437 + @@ -18383,8 +26496,18 @@ + The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. morphogenesis of an epithelium + + + + The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. + GOC:dph + GOC:jl + GOC:tb + ISBN:0198506732 + @@ -18409,8 +26532,15 @@ + The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. morphogenesis of an epithelial sheet + + + + The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. + GOC:jl + @@ -18418,8 +26548,17 @@ + Any process that modulates the frequency or rate of heart contraction. regulation of heart rate + + + + Any process that modulates the frequency or rate of heart contraction. + GOC:dph + GOC:tb + PMID:10358008 + @@ -18446,8 +26585,15 @@ + Any process that activates or increases the rate of neuroblast proliferation. positive regulation of neuroblast proliferation + + + + Any process that activates or increases the rate of neuroblast proliferation. + GOC:dph + @@ -18473,8 +26619,15 @@ + The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. positive regulation of mesenchymal cell proliferation + + + + The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. + GOC:dph + @@ -18505,8 +26658,15 @@ + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. chondrocyte differentiation + + + + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. + GOC:dph + @@ -18537,8 +26697,15 @@ + The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. chondrocyte development + + + + The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + GOC:dph + @@ -18569,8 +26736,15 @@ + The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. epithelial cell development + + + + The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. + GOC:dph + @@ -18595,8 +26769,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. columnar/cuboidal epithelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. + GOC:dph + @@ -18627,8 +26808,15 @@ + The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. columnar/cuboidal epithelial cell development + + + + The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. + GOC:dph + @@ -18653,8 +26841,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. glandular epithelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. + GOC:dph + @@ -18685,8 +26880,15 @@ + The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. glandular epithelial cell development + + + + The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. + GOC:dph + @@ -18717,8 +26919,15 @@ + The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. columnar/cuboidal epithelial cell maturation + + + + The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. + GOC:dph + @@ -18749,8 +26958,15 @@ + The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. epithelial cell maturation + + + + The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. + GOC:dph + @@ -18781,8 +26997,15 @@ + The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. glandular epithelial cell maturation + + + + The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. + GOC:dph + @@ -18813,8 +27036,19 @@ + The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. optic cup morphogenesis involved in camera-type eye development + + + + The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. + GOC:dph + GOC:mtg_sensu + GOC:sdb_2009 + GOC:tb + ISBN:0878932437 + @@ -18842,8 +27076,16 @@ + Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells. inhibition of neuroepithelial cell differentiation + + + + Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells. + GOC:dph + PMID:16678814 + @@ -18863,8 +27105,17 @@ + A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. regulation of respiratory gaseous exchange by nervous system process + + + + A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. + GOC:dph + GOC:tb + PMID:12458206 + @@ -18895,8 +27146,16 @@ + The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. lens development in camera-type eye + + + + The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. + GOC:dph + ISBN:0582064333 + @@ -18933,8 +27192,16 @@ + The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. lens morphogenesis in camera-type eye + + + + The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. + GOC:dph + GOC:mtg_sensu + @@ -18959,8 +27226,16 @@ + The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. osteoclast proliferation + + + + The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. + CL:0000092 + GOC:hjd + @@ -18985,8 +27260,15 @@ + A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism. defense response to insect + + + + A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism. + GOC:add + @@ -19006,8 +27288,16 @@ + The movement of an immune cell in response to an external stimulus contributing to an inflammatory response. leukocyte chemotaxis involved in inflammatory response + + + + The movement of an immune cell in response to an external stimulus contributing to an inflammatory response. + GOC:add + ISBN:0781735149 + @@ -19027,8 +27317,16 @@ + The movement of an immune cell in response to an external stimulus a part of an immune response. leukocyte chemotaxis involved in immune response + + + + The movement of an immune cell in response to an external stimulus a part of an immune response. + GOC:add + ISBN:0781735149 + @@ -19059,8 +27357,18 @@ + The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. hematopoietic progenitor cell differentiation + + + + The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. + GOC:add + GOC:rl + ISBN:0781735149 + PMID:16551251 + @@ -19080,8 +27388,35 @@ + An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). + Wikipedia:Adaptive_immune_system adaptive immune response + + + + An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). + GOC:add + GO_REF:0000022 + ISBN:0781735149 + + + + + + + + + An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. + organ or tissue specific immune response + + + + + An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. + GOC:jal + GO_REF:0000022 + @@ -19089,8 +27424,17 @@ + Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. immune effector process + + + + Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19115,8 +27459,19 @@ + The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. lymphocyte homeostasis + + + + The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. + GOC:add + PMID:15826826 + PMID:16319493 + PMID:16551252 + PMID:16551262 + @@ -19142,8 +27497,16 @@ + The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. myeloid cell homeostasis + + + + The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. + CL:0000763 + GOC:add + @@ -19169,8 +27532,17 @@ + A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. cell activation involved in immune response + + + + A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19190,8 +27562,16 @@ + A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. endothelial cell activation involved in immune response + + + + A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19216,8 +27596,16 @@ + A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response. leukocyte activation involved in inflammatory response + + + + A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response. + GOC:add + ISBN:0781735149 + @@ -19242,8 +27630,16 @@ + A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. myeloid leukocyte activation + + + + A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. + GOC:add + ISBN:0781735149 + @@ -19252,8 +27648,16 @@ + A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. myeloid cell activation involved in immune response + + + + A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19273,8 +27677,16 @@ + The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. myeloid dendritic cell activation involved in immune response + + + + The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19294,8 +27706,17 @@ + The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. monocyte activation involved in immune response + + + + The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + PMID:16551245 + @@ -19321,8 +27742,16 @@ + A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. macrophage activation involved in immune response + + + + A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19342,8 +27771,16 @@ + The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response. myeloid dendritic cell differentiation involved in immune response + + + + The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response. + GOC:add + ISBN:0781735149 + @@ -19363,8 +27800,16 @@ + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. lymphocyte activation involved in immune response + + + + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19384,8 +27829,16 @@ + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. T cell activation involved in immune response + + + + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19405,8 +27858,17 @@ + The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. T cell differentiation involved in immune response + + + + The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. + GOC:add + ISBN:0781735149 + @@ -19426,8 +27888,16 @@ + The expansion of a T cell population by cell division as part of an immune response. T cell proliferation involved in immune response + + + + The expansion of a T cell population by cell division as part of an immune response. + GOC:add + ISBN:0781735149 + @@ -19452,8 +27922,16 @@ + The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. myeloid progenitor cell differentiation + + + + The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. + GOC:add + PMID:16551264 + @@ -19478,8 +27956,17 @@ + The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. lymphoid progenitor cell differentiation + + + + The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. + GOC:add + PMID:16551251 + PMID:16551264 + @@ -19487,8 +27974,17 @@ + The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. serotonin production involved in inflammatory response + + + + The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. + GOC:add + ISBN:0781735149 + PMID:16730260 + @@ -19508,8 +28004,16 @@ + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. leukocyte activation involved in immune response + + + + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. + GOC:add + ISBN:0781735149 + @@ -19535,8 +28039,18 @@ + The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. cytokine production involved in immune response + + + + The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19556,8 +28070,17 @@ + Any process that contributes to cytokine production by a T cell. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. T cell cytokine production + + + + Any process that contributes to cytokine production by a T cell. + GOC:add + ISBN:0781735149 + @@ -19583,8 +28106,17 @@ + Any process that contributes to cytokine production by a dendritic cell. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. dendritic cell cytokine production + + + + Any process that contributes to cytokine production by a dendritic cell. + GOC:add + ISBN:0781735149 + @@ -19611,8 +28143,17 @@ + Any process that contributes to cytokine production by a myeloid dendritic cell. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. myeloid dendritic cell cytokine production + + + + Any process that contributes to cytokine production by a myeloid dendritic cell. + GOC:add + ISBN:0781735149 + @@ -19646,8 +28187,65 @@ + Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. + Wikipedia:Immune_system + Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). immune system process + + + + Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. + GOC:add + GO_REF:0000022 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An immune response taking place in the liver. + hepatic immune response + + + + + An immune response taking place in the liver. + GOC:jal + GO_REF:0000022 + ISBN:0781735149 + @@ -19672,8 +28270,18 @@ + The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex. MHC protein complex assembly + + + + The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex. + GOC:add + ISBN:0781735149 + PMID:15771591 + PMID:15928678 + @@ -19698,8 +28306,17 @@ + The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex. MHC class II protein complex assembly + + + + The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex. + GOC:add + ISBN:0781735149 + PMID:15771591 + @@ -19719,8 +28336,19 @@ + The movement of a dendritic cell in response to an external stimulus. dendritic cell chemotaxis + + + + The movement of a dendritic cell in response to an external stimulus. + CL:0000451 + GOC:add + ISBN:0781735149 + PMID:15814331 + PMID:16056255 + @@ -19746,8 +28374,18 @@ + The movement of a myeloid dendritic cell in response to an external stimulus. myeloid dendritic cell chemotaxis + + + + The movement of a myeloid dendritic cell in response to an external stimulus. + GOC:add + ISBN:0781735149 + PMID:15814331 + PMID:16056255 + @@ -19756,8 +28394,18 @@ + The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. production of molecular mediator of immune response + + + + The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19782,8 +28430,16 @@ + The regulated release of serotonin by a cell as part of an inflammatory response. serotonin secretion involved in inflammatory response + + + + The regulated release of serotonin by a cell as part of an inflammatory response. + GOC:add + ISBN:0781735149 + @@ -19820,8 +28476,17 @@ + Any process involved in the carrying out of an immune response by a leukocyte. leukocyte mediated immunity + + + + Any process involved in the carrying out of an immune response by a leukocyte. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19846,8 +28511,17 @@ + Any process involved in the carrying out of an immune response by a myeloid leukocyte. myeloid leukocyte mediated immunity + + + + Any process involved in the carrying out of an immune response by a myeloid leukocyte. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19872,8 +28546,17 @@ + Any process involved in the carrying out of an immune response by a lymphocyte. lymphocyte mediated immunity + + + + Any process involved in the carrying out of an immune response by a lymphocyte. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19899,8 +28582,17 @@ + Any process involved in the carrying out of an immune response by a T cell. T cell mediated immunity + + + + Any process involved in the carrying out of an immune response by a T cell. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + @@ -19931,8 +28623,17 @@ + The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. T cell antigen processing and presentation + + + + The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + PMID:11417857 + PMID:15120183 + @@ -19940,8 +28641,18 @@ + An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + + + + An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. + GOC:add + GOC:mtg_sensu + ISBN:0781735149 + ISBN:1405196831 + @@ -19966,8 +28677,17 @@ + The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. dendritic cell antigen processing and presentation + + + + The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + ISBN:0781735149 + PMID:15771591 + @@ -19992,8 +28712,17 @@ + The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. myeloid dendritic cell antigen processing and presentation + + + + The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + ISBN:0781735149 + PMID:15771591 + @@ -20018,8 +28747,16 @@ + The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. monocyte antigen processing and presentation + + + + The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + PMID:11200054 + @@ -20044,8 +28781,17 @@ + The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. macrophage antigen processing and presentation + + + + The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + ISBN:0781735149 + PMID:15771591 + @@ -20053,8 +28799,19 @@ + The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + + + + The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. + GOC:add + ISBN:0781735149 + PMID:15531770 + PMID:15771591 + PMID:16153240 + @@ -20080,8 +28837,16 @@ + The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. immune system development + + + + The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. + GOC:add + GOC:dph + @@ -20112,8 +28877,17 @@ + The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. leukocyte differentiation + + + + The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + CL:0000738 + GOC:add + PMID:16551264 + @@ -20139,8 +28913,20 @@ + The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response. leukocyte migration involved in immune response + + + + The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response. + GOC:add + ISBN:0781735149 + PMID:14680625 + PMID:14708592 + PMID:7507411 + PMID:8600538 + @@ -20165,8 +28951,20 @@ + The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. leukocyte migration involved in inflammatory response + + + + The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. + GOC:add + ISBN:0781735149 + PMID:14680625 + PMID:14708592 + PMID:7507411 + PMID:8600538 + @@ -20180,8 +28978,18 @@ + The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. production of molecular mediator involved in inflammatory response + + + + The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:add + GOC:dph + GOC:tb + ISBN:0781735149 + @@ -20201,8 +29009,16 @@ + The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. cytokine production involved in inflammatory response + + + + The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. + GOC:add + ISBN:0781735149 + @@ -20229,8 +29045,17 @@ + The movement of a monocyte in response to an external stimulus. monocyte chemotaxis + + + + The movement of a monocyte in response to an external stimulus. + GOC:add + PMID:11696603 + PMID:15173832 + @@ -20261,8 +29086,16 @@ + The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed. pro-T cell differentiation + + + + The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed. + GOC:add + ISBN:0781735149 + @@ -20288,8 +29121,16 @@ + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. myeloid leukocyte differentiation + + + + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. + GOC:add + PMID:16551251 + @@ -20314,8 +29155,15 @@ + Any process that modulates the frequency, rate, or extent of antigen processing and presentation. regulation of antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of antigen processing and presentation. + GOC:add + @@ -20341,8 +29189,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation. negative regulation of antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation. + GOC:add + @@ -20368,8 +29223,15 @@ + Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. positive regulation of antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. + GOC:add + @@ -20394,8 +29256,15 @@ + Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + + + + Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. + GOC:add + @@ -20421,8 +29290,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. + GOC:add + @@ -20448,8 +29324,15 @@ + Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + + + + Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II. + GOC:add + @@ -20474,8 +29357,15 @@ + Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation. regulation of dendritic cell antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation. + GOC:add + @@ -20501,8 +29391,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation. negative regulation of dendritic cell antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation. + GOC:add + @@ -20528,8 +29425,15 @@ + Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation. positive regulation of dendritic cell antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation. + GOC:add + @@ -20554,8 +29458,15 @@ + Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. regulation of myeloid dendritic cell antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. + GOC:add + @@ -20581,8 +29492,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. negative regulation of myeloid dendritic cell antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. + GOC:add + @@ -20608,8 +29526,15 @@ + Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. positive regulation of myeloid dendritic cell antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation. + GOC:add + @@ -20634,8 +29559,15 @@ + Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation. regulation of monocyte antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation. + GOC:add + @@ -20661,8 +29593,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation. negative regulation of monocyte antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation. + GOC:add + @@ -20688,8 +29627,15 @@ + Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation. positive regulation of monocyte antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation. + GOC:add + @@ -20714,8 +29660,15 @@ + Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation. regulation of macrophage antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation. + GOC:add + @@ -20741,8 +29694,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation. negative regulation of macrophage antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation. + GOC:add + @@ -20768,8 +29728,15 @@ + Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation. positive regulation of macrophage antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation. + GOC:add + @@ -20795,8 +29762,15 @@ + Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation. regulation of T cell antigen processing and presentation + + + + Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation. + GOC:add + @@ -20823,8 +29797,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation. negative regulation of T cell antigen processing and presentation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation. + GOC:add + @@ -20851,8 +29832,15 @@ + Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation. positive regulation of T cell antigen processing and presentation + + + + Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation. + GOC:add + @@ -20877,8 +29865,15 @@ + Any process that modulates the frequency, rate, or extent of an immune system process. regulation of immune system process + + + + Any process that modulates the frequency, rate, or extent of an immune system process. + GOC:add + @@ -20904,8 +29899,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. negative regulation of immune system process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. + GOC:add + @@ -20931,8 +29933,15 @@ + Any process that activates or increases the frequency, rate, or extent of an immune system process. positive regulation of immune system process + + + + Any process that activates or increases the frequency, rate, or extent of an immune system process. + GOC:add + @@ -20958,8 +29967,15 @@ + Any process that modulates the frequency, rate, or extent of leukocyte migration. regulation of leukocyte migration + + + + Any process that modulates the frequency, rate, or extent of leukocyte migration. + GOC:add + @@ -20986,8 +30002,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. negative regulation of leukocyte migration + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. + GOC:add + @@ -21014,8 +30037,15 @@ + Any process that activates or increases the frequency, rate, or extent of leukocyte migration. positive regulation of leukocyte migration + + + + Any process that activates or increases the frequency, rate, or extent of leukocyte migration. + GOC:add + @@ -21041,8 +30071,15 @@ + Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. regulation of leukocyte chemotaxis + + + + Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. + GOC:add + @@ -21069,8 +30106,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. negative regulation of leukocyte chemotaxis + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. + GOC:add + @@ -21097,8 +30141,15 @@ + Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. positive regulation of leukocyte chemotaxis + + + + Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. + GOC:add + @@ -21124,8 +30175,15 @@ + Any process that modulates the frequency, rate, or extent of leukocyte activation. regulation of leukocyte activation + + + + Any process that modulates the frequency, rate, or extent of leukocyte activation. + GOC:add + @@ -21152,8 +30210,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation. negative regulation of leukocyte activation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation. + GOC:add + @@ -21180,8 +30245,15 @@ + Any process that activates or increases the frequency, rate, or extent of leukocyte activation. positive regulation of leukocyte activation + + + + Any process that activates or increases the frequency, rate, or extent of leukocyte activation. + GOC:add + @@ -21206,8 +30278,15 @@ + Any process that modulates the frequency, rate, or extent of an immune effector process. regulation of immune effector process + + + + Any process that modulates the frequency, rate, or extent of an immune effector process. + GOC:add + @@ -21233,8 +30312,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. negative regulation of immune effector process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. + GOC:add + @@ -21260,8 +30346,15 @@ + Any process that activates or increases the frequency, rate, or extent of an immune effector process. positive regulation of immune effector process + + + + Any process that activates or increases the frequency, rate, or extent of an immune effector process. + GOC:add + @@ -21287,8 +30380,15 @@ + Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. regulation of production of molecular mediator of immune response + + + + Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. + GOC:add + @@ -21315,8 +30415,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. negative regulation of production of molecular mediator of immune response + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. + GOC:add + @@ -21343,8 +30450,15 @@ + Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. positive regulation of production of molecular mediator of immune response + + + + Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. + GOC:add + @@ -21369,8 +30483,15 @@ + Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. regulation of leukocyte mediated immunity + + + + Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. + GOC:add + @@ -21396,8 +30517,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. negative regulation of leukocyte mediated immunity + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. + GOC:add + @@ -21423,8 +30551,15 @@ + Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. positive regulation of leukocyte mediated immunity + + + + Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. + GOC:add + @@ -21449,8 +30584,15 @@ + Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. regulation of lymphocyte mediated immunity + + + + Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. + GOC:add + @@ -21476,8 +30618,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. negative regulation of lymphocyte mediated immunity + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. + GOC:add + @@ -21503,8 +30652,15 @@ + Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. positive regulation of lymphocyte mediated immunity + + + + Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. + GOC:add + @@ -21530,8 +30686,15 @@ + Any process that modulates the frequency, rate, or extent of T cell mediated immunity. regulation of T cell mediated immunity + + + + Any process that modulates the frequency, rate, or extent of T cell mediated immunity. + GOC:add + @@ -21558,8 +30721,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. negative regulation of T cell mediated immunity + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. + GOC:add + @@ -21586,8 +30756,15 @@ + Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. positive regulation of T cell mediated immunity + + + + Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. + GOC:add + @@ -21613,8 +30790,15 @@ + Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. regulation of cytokine production involved in immune response + + + + Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. + GOC:add + @@ -21641,8 +30825,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. negative regulation of cytokine production involved in immune response + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. + GOC:add + @@ -21669,8 +30860,15 @@ + Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. positive regulation of cytokine production involved in immune response + + + + Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. + GOC:add + @@ -21696,8 +30894,15 @@ + Any process that modulates the frequency, rate, or extent of T cell cytokine production. regulation of T cell cytokine production + + + + Any process that modulates the frequency, rate, or extent of T cell cytokine production. + GOC:add + @@ -21724,8 +30929,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production. negative regulation of T cell cytokine production + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production. + GOC:add + @@ -21752,8 +30964,15 @@ + Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. positive regulation of T cell cytokine production + + + + Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. + GOC:add + @@ -21779,8 +30998,15 @@ + Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production. regulation of dendritic cell cytokine production + + + + Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production. + GOC:add + @@ -21807,8 +31033,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production. negative regulation of dendritic cell cytokine production + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production. + GOC:add + @@ -21835,8 +31068,15 @@ + Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production. positive regulation of dendritic cell cytokine production + + + + Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production. + GOC:add + @@ -21862,8 +31102,15 @@ + Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production. regulation of myeloid dendritic cell cytokine production + + + + Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production. + GOC:add + @@ -21890,8 +31137,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production. negative regulation of myeloid dendritic cell cytokine production + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production. + GOC:add + @@ -21919,8 +31173,15 @@ + Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production. positive regulation of myeloid dendritic cell cytokine production + + + + Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production. + GOC:add + @@ -21946,8 +31207,15 @@ + Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. regulation of myeloid leukocyte differentiation + + + + Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. + GOC:add + @@ -21974,8 +31242,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. negative regulation of myeloid leukocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. + GOC:add + @@ -22002,8 +31277,15 @@ + Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. positive regulation of myeloid leukocyte differentiation + + + + Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. + GOC:add + @@ -22023,8 +31305,15 @@ + The controlled release of a peptide from a cell or a tissue. peptide secretion + + + + The controlled release of a peptide from a cell or a tissue. + GOC:add + @@ -22050,8 +31339,15 @@ + Any process that modulates the frequency, rate, or extent of peptide secretion. regulation of peptide secretion + + + + Any process that modulates the frequency, rate, or extent of peptide secretion. + GOC:add + @@ -22077,8 +31373,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. negative regulation of peptide secretion + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. + GOC:add + @@ -22104,8 +31407,15 @@ + Any process that activates or increases the frequency, rate, or extent of peptide secretion. positive regulation of peptide secretion + + + + Any process that activates or increases the frequency, rate, or extent of peptide secretion. + GOC:add + @@ -22130,8 +31440,15 @@ + Any process that modulates the frequency, rate, or extent of an adaptive immune response. regulation of adaptive immune response + + + + Any process that modulates the frequency, rate, or extent of an adaptive immune response. + GOC:add + @@ -22157,8 +31474,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. negative regulation of adaptive immune response + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. + GOC:add + @@ -22184,8 +31508,15 @@ + Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. positive regulation of adaptive immune response + + + + Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. + GOC:add + @@ -22222,8 +31553,16 @@ + Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + + + + Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. + GOC:add + GOC:mtg_sensu + @@ -22249,8 +31588,16 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. + GOC:add + GOC:mtg_sensu + @@ -22276,8 +31623,16 @@ + Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + + + + Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. + GOC:add + GOC:mtg_sensu + @@ -22302,8 +31657,16 @@ + Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of response to biotic stimulus + + + + Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. + GOC:add + @@ -22329,8 +31692,16 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of response to biotic stimulus + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. + GOC:add + @@ -22356,8 +31727,16 @@ + Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of response to biotic stimulus + + + + Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. + GOC:add + @@ -22382,8 +31761,15 @@ + Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. regulation of myeloid leukocyte mediated immunity + + + + Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. + GOC:add + @@ -22409,8 +31795,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity. negative regulation of myeloid leukocyte mediated immunity + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity. + GOC:add + @@ -22436,8 +31829,15 @@ + Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. positive regulation of myeloid leukocyte mediated immunity + + + + Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. + GOC:add + @@ -22468,8 +31868,15 @@ + The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move. tendon sheath development + + + + The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move. + PMID:20696843 + @@ -22477,8 +31884,16 @@ + The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. regionalization + + + + The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. + GOC:dph + GOC:isa_complete + @@ -22495,8 +31910,16 @@ + A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. developmental process involved in reproduction + + + + A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. + GOC:dph + GOC:isa_complete + @@ -22527,8 +31950,16 @@ + The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. heart morphogenesis + + + + The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + GOC:dph + GOC:isa_complete + @@ -22536,8 +31967,15 @@ + A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. system process + + + + A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. + GOC:mtg_cardio + @@ -22568,8 +32006,16 @@ + A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. skeletal muscle contraction + + + + A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. + GOC:mtg_cardio + GOC:mtg_muscle + @@ -22577,8 +32023,15 @@ + A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. muscle system process + + + + A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. + GOC:mtg_cardio + @@ -22586,8 +32039,34 @@ + A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. + Wikipedia:Circulatory_system circulatory system process + + + + A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. + GOC:mtg_cardio + + + + + + + + + A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). + renal system process + + + + + A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). + GOC:cjm + GOC:mtg_cardio + GOC:mtg_kidney_jan10 + @@ -22595,8 +32074,15 @@ + A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. heart process + + + + A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + GOC:mtg_cardio + @@ -22610,8 +32096,17 @@ + A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. respiratory system process + + + + A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. + GOC:dph + GOC:mtg_cardio + GOC:tb + @@ -22620,8 +32115,15 @@ + The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. detection of oxygen + + + + The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. + GOC:mtg_cardio + @@ -22656,8 +32158,15 @@ + Any process that mediates the transfer of information from mesodermal cells to endodermal cells. mesodermal-endodermal cell signaling + + + + Any process that mediates the transfer of information from mesodermal cells to endodermal cells. + GOC:mtg_heart + @@ -22692,8 +32201,15 @@ + Any process that mediates the transfer of information from endodermal cells to mesodermal cells. endodermal-mesodermal cell signaling + + + + Any process that mediates the transfer of information from endodermal cells to mesodermal cells. + GOC:mtg_heart + @@ -22724,8 +32240,15 @@ + The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field. cardiogenic plate morphogenesis + + + + The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field. + GOC:mtg_heart + @@ -22769,8 +32292,15 @@ + The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. embryonic heart tube morphogenesis + + + + The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. + GOC:mtg_heart + @@ -22801,8 +32331,15 @@ + The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. embryonic heart tube formation + + + + The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. + GOC:mtg_heart + @@ -22810,8 +32347,15 @@ + The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis. embryonic heart tube formation via epithelial folding + + + + The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis. + GOC:mtg_heart + @@ -22837,8 +32381,15 @@ + The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation. neural crest cell migration involved in heart formation + + + + The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation. + GOC:mtg_heart + @@ -22869,8 +32420,15 @@ + The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. outflow tract septum morphogenesis + + + + The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. + GOC:mtg_heart + @@ -22901,8 +32459,15 @@ + The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. membranous septum morphogenesis + + + + The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. + GOC:mtg_heart + @@ -22933,8 +32498,15 @@ + The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. muscular septum morphogenesis + + + + The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. + GOC:mtg_heart + @@ -22965,8 +32537,16 @@ + The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. outflow tract morphogenesis + + + + The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. + GOC:mtg_heart + UBERON:0004145 + @@ -22992,8 +32572,15 @@ + The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation. morphogenesis of an epithelial fold involved in embryonic heart tube formation + + + + The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation. + GOC:mtg_heart + @@ -23018,8 +32605,17 @@ + Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. regulation of animal organ formation + + + + Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. + GOC:dph + GOC:mtg_heart + GOC:tb + @@ -23050,8 +32646,15 @@ + The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. endocardium development + + + + The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:mtg_heart + @@ -23076,8 +32679,15 @@ + The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. endothelium development + + + + The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. + GOC:mtg_heart + @@ -23108,8 +32718,15 @@ + The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. morphogenesis of an endothelium + + + + The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. + GOC:mtg_heart + @@ -23140,8 +32757,15 @@ + The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. endocardium morphogenesis + + + + The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:mtg_heart + @@ -23166,8 +32790,15 @@ + The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. cardiac conduction system development + + + + The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. + GOC:mtg_heart + @@ -23198,8 +32829,15 @@ + The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system. atrioventricular node development + + + + The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system. + GOC:mtg_heart + @@ -23230,8 +32868,15 @@ + The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. sinoatrial node development + + + + The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. + GOC:mtg_heart + @@ -23262,8 +32907,15 @@ + The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. His-Purkinje system development + + + + The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. + GOC:mtg_heart + @@ -23294,8 +32946,16 @@ + The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. Purkinje myocyte development + + + + The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_heart + @@ -23326,8 +32986,16 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle. Purkinje myocyte differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle. + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_heart + @@ -23353,8 +33021,15 @@ + The process in which the anatomical structures of veins of the heart are generated and organized. coronary vein morphogenesis + + + + The process in which the anatomical structures of veins of the heart are generated and organized. + GOC:mtg_heart + @@ -23385,8 +33060,15 @@ + The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. endocardial cushion development + + + + The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. + GOC:mtg_heart + @@ -23423,8 +33105,15 @@ + The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. endocardial cushion morphogenesis + + + + The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. + GOC:mtg_heart + @@ -23455,8 +33144,15 @@ + The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart. cardiac skeleton development + + + + The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart. + GOC:mtg_heart + @@ -23487,8 +33183,15 @@ + The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. cardiac chamber development + + + + The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. + GOC:mtg_heart + @@ -23525,8 +33228,15 @@ + The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. cardiac chamber morphogenesis + + + + The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. + GOC:mtg_heart + @@ -23557,8 +33267,15 @@ + The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. cardiac chamber formation + + + + The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. + GOC:mtg_heart + @@ -23589,8 +33306,15 @@ + The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. cardiac ventricle morphogenesis + + + + The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. + GOC:mtg_heart + @@ -23621,8 +33345,15 @@ + The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. cardiac atrium morphogenesis + + + + The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. + GOC:mtg_heart + @@ -23653,8 +33384,15 @@ + The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. cardiac atrium formation + + + + The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. + GOC:mtg_heart + @@ -23685,8 +33423,15 @@ + The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. cardiac ventricle formation + + + + The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. + GOC:mtg_heart + @@ -23711,8 +33456,15 @@ + The process in which the left cardiac atrium is generated and organized. cardiac left atrium morphogenesis + + + + The process in which the left cardiac atrium is generated and organized. + GOC:mtg_heart + @@ -23737,8 +33489,15 @@ + The process in which the right cardiac atrium is generated and organized. cardiac right atrium morphogenesis + + + + The process in which the right cardiac atrium is generated and organized. + GOC:mtg_heart + @@ -23763,8 +33522,15 @@ + The process in which the left cardiac ventricle is generated and organized. cardiac left ventricle morphogenesis + + + + The process in which the left cardiac ventricle is generated and organized. + GOC:mtg_heart + @@ -23789,8 +33555,15 @@ + The process in which the right cardiac ventricle is generated and organized. cardiac right ventricle morphogenesis + + + + The process in which the right cardiac ventricle is generated and organized. + GOC:mtg_heart + @@ -23821,8 +33594,15 @@ + The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts. cardiac left atrium formation + + + + The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts. + GOC:mtg_heart + @@ -23853,8 +33633,15 @@ + The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts. cardiac right atrium formation + + + + The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts. + GOC:mtg_heart + @@ -23885,8 +33672,15 @@ + The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts. cardiac left ventricle formation + + + + The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts. + GOC:mtg_heart + @@ -23917,8 +33711,15 @@ + The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts. cardiac right ventricle formation + + + + The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts. + GOC:mtg_heart + @@ -23949,8 +33750,15 @@ + The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized. left ventricular cardiac muscle tissue morphogenesis + + + + The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized. + GOC:mtg_heart + @@ -23981,8 +33789,117 @@ + The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized. right ventricular cardiac muscle tissue morphogenesis + + + + The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized. + GOC:mtg_heart + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. + ventricular trabecula myocardium morphogenesis + + + + + The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. + GOC:mtg_heart + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized. + left ventricular trabecular myocardium morphogenesis + + + + + The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized. + GOC:mtg_heart + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the anatomical structures of the right ventricular myocardium are generated and organized. + right ventricular trabecular myocardium morphogenesis + + + + + The process in which the anatomical structures of the right ventricular myocardium are generated and organized. + GOC:mtg_heart + @@ -24007,8 +33924,15 @@ + The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure. atrial cardiac muscle tissue development + + + + The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure. + GOC:mtg_heart + @@ -24033,8 +33957,15 @@ + The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. ventricular cardiac muscle tissue development + + + + The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. + GOC:mtg_heart + @@ -24059,8 +33990,15 @@ + The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. cardiac atrium development + + + + The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. + GOC:mtg_heart + @@ -24085,8 +34023,15 @@ + The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. cardiac ventricle development + + + + The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. + GOC:mtg_heart + @@ -24111,8 +34056,15 @@ + The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. sinus venosus development + + + + The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. + GOC:mtg_heart + @@ -24143,8 +34095,15 @@ + The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. sinus venosus morphogenesis + + + + The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. + GOC:mtg_heart + @@ -24175,8 +34134,15 @@ + The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. sinus venosus formation + + + + The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. + GOC:mtg_heart + @@ -24207,8 +34173,15 @@ + Developmental growth that contributes to the shaping of the heart. growth involved in heart morphogenesis + + + + Developmental growth that contributes to the shaping of the heart. + GOC:mtg_heart + @@ -24234,8 +34207,15 @@ + The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart. cardiac muscle tissue growth involved in heart morphogenesis + + + + The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart. + GOC:mtg_heart + @@ -24272,8 +34252,15 @@ + The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle. heart capillary growth + + + + The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle. + GOC:mtg_heart + @@ -24299,8 +34286,15 @@ + The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract. cardiac neural crest cell migration involved in outflow tract morphogenesis + + + + The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract. + GOC:mtg_heart + @@ -24325,8 +34319,15 @@ + The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. cardioblast migration + + + + The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. + GOC:mtg_heart + @@ -24357,8 +34358,16 @@ + The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. endocardial cushion formation + + + + The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. + GOC:mtg_heart + PMID:15797462 + @@ -24383,8 +34392,15 @@ + The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. cell migration involved in endocardial cushion formation + + + + The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. + GOC:mtg_heart + @@ -24409,8 +34425,16 @@ + Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries. apoptotic process involved in outflow tract morphogenesis + + + + Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries. + GOC:mtg_apoptosis + GOC:mtg_heart + @@ -24435,8 +34459,16 @@ + Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. apoptotic process involved in endocardial cushion morphogenesis + + + + Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. + GOC:mtg_apoptosis + GOC:mtg_heart + @@ -24461,8 +34493,16 @@ + Any apoptotic process that contributes to the shaping of the heart. apoptotic process involved in heart morphogenesis + + + + Any apoptotic process that contributes to the shaping of the heart. + GOC:mtg_apoptosis + GOC:mtg_heart + @@ -24493,8 +34533,15 @@ + The progression of a cardiac septum over time, from its initial formation to the mature structure. cardiac septum development + + + + The progression of a cardiac septum over time, from its initial formation to the mature structure. + GOC:mtg_heart + @@ -24525,8 +34572,15 @@ + The progression of the ventricular septum over time from its formation to the mature structure. ventricular septum development + + + + The progression of the ventricular septum over time from its formation to the mature structure. + GOC:mtg_heart + @@ -24557,8 +34611,15 @@ + The progression of the atrial septum over time, from its initial formation to the mature structure. atrial septum development + + + + The progression of the atrial septum over time, from its initial formation to the mature structure. + GOC:mtg_heart + @@ -24589,8 +34650,15 @@ + The process in which an endocardial cushion cell becomes a cell of a cardiac septum. cardiac septum cell differentiation + + + + The process in which an endocardial cushion cell becomes a cell of a cardiac septum. + GOC:mtg_heart + @@ -24598,8 +34666,15 @@ + The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development. physiological muscle hypertrophy + + + + The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development. + GOC:mtg_heart + @@ -24607,8 +34682,15 @@ + The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. cardiac muscle hypertrophy + + + + The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. + GOC:mtg_heart + @@ -24623,8 +34705,178 @@ + The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart. physiological cardiac muscle hypertrophy + + + + The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_heart + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + type B pancreatic cell differentiation + + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + CL:0000169 + GOC:dph + PMID:11076772 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. + pancreatic A cell differentiation + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. + GOC:dph + PMID:11076772 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin. + pancreatic D cell differentiation + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin. + GOC:dph + PMID:11076772 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. + pancreatic PP cell differentiation + + + + + The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. + GOC:dph + PMID:11076772 + @@ -24655,8 +34907,15 @@ + The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. heart rudiment development + + + + The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. + GOC:mtg_heart + @@ -24688,8 +34947,15 @@ + The process in which the anatomical structures of the heart rudiment are generated and organized. heart rudiment morphogenesis + + + + The process in which the anatomical structures of the heart rudiment are generated and organized. + GOC:mtg_heart + @@ -24720,8 +34986,172 @@ + The developmental process pertaining to the initial formation of the heart rudiment. heart rudiment formation + + + + The developmental process pertaining to the initial formation of the heart rudiment. + GOC:mtg_heart + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon. + pancreatic A cell development + + + + + The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + type B pancreatic cell development + + + + + The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + CL:0000169 + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin. + pancreatic D cell development + + + + + The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. + pancreatic PP cell development + + + + + The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. + GOC:dph + @@ -24918,8 +35348,17 @@ + The directed, self-propelled movement of a cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. cilium movement + + + + The directed, self-propelled movement of a cilium. + GOC:dph + GOC:jl + @@ -24950,8 +35389,16 @@ + The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum. proepicardium development + + + + The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum. + GOC:dph + PMID:18722343 + @@ -24976,8 +35423,16 @@ + The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme. septum transversum development + + + + The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme. + GOC:dph + PMID:18722343 + @@ -25009,8 +35464,16 @@ + The process in which the anatomical structure of the pericardium is generated and organized. pericardium morphogenesis + + + + The process in which the anatomical structure of the pericardium is generated and organized. + GOC:dph + PMID:18722343 + @@ -25036,8 +35499,16 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. cardiac endothelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. + GOC:dph + PMID:18722343 + @@ -25062,8 +35533,16 @@ + Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. regulation of cilium movement + + + + Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + GOC:dph + @@ -25089,8 +35568,16 @@ + Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. positive regulation of cilium movement + + + + Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + GOC:dph + @@ -25116,8 +35603,16 @@ + Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. negative regulation of cilium movement + + + + Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. + GOC:dph + @@ -25142,8 +35637,15 @@ + The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. brainstem development + + + + The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. + GOC:dph + @@ -25194,8 +35696,17 @@ + The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell. establishment of cell polarity involved in ameboidal cell migration + + + + The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25220,8 +35731,17 @@ + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell. establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration + + + + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25246,8 +35766,17 @@ + The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation. establishment of cell polarity involved in gastrulation cell migration + + + + The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25272,8 +35801,17 @@ + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation. establishment or maintenance of cytoskeleton polarity involved in gastrulation + + + + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25298,8 +35836,17 @@ + The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation. epithelial cell morphogenesis involved in gastrulation + + + + The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25330,8 +35877,17 @@ + The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. epithelial cell morphogenesis + + + + The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25368,8 +35924,17 @@ + The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. optic vesicle formation + + + + The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25401,8 +35966,17 @@ + The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. optic vesicle morphogenesis + + + + The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25433,8 +36007,17 @@ + The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. neural retina development + + + + The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25459,8 +36042,17 @@ + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye. cell motility involved in camera-type eye morphogenesis + + + + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25485,8 +36077,17 @@ + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. chondrocyte differentiation involved in endochondral bone morphogenesis + + + + The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25511,8 +36112,17 @@ + The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized. chondrocyte morphogenesis involved in endochondral bone morphogenesis + + + + The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25537,8 +36147,17 @@ + The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. endochondral bone growth + + + + The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -25563,8 +36182,385 @@ + The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. chondrocyte development involved in endochondral bone morphogenesis + + + + The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. + GOC:ascb_2009 + GOC:dph + GOC:tb + + + + + + + + + + + A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. + Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. + molecular_function + + + + + A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. + GOC:pdt + + + + + + + + + Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. + Wikipedia:Enzyme + catalytic activity + + + + + Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. + GOC:vw + ISBN:0198506732 + + + + + + + + + Catalysis of the hydrolysis of ester linkages within nucleic acids. + Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. + nuclease activity + + + + + Catalysis of the hydrolysis of ester linkages within nucleic acids. + ISBN:0198547684 + + + + + + + + + + + + + + + + Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. + Reactome:R-HSA-211247 + Reactome:R-HSA-5685994 + Reactome:R-HSA-6785986 + DNA nuclease activity + + + + + Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. + GOC:mah + ISBN:0198547684 + + + + + Reactome:R-HSA-211247 + Cleavage of DNA by DFF40 + + + + + Reactome:R-HSA-5685994 + Long-range resection of DNA DSBs by EXO1 or DNA2 + + + + + Reactome:R-HSA-6785986 + DNA nucleases unhook the interstrand crosslink (ICL) + + + + + + + + + Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells. + Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. + transporter activity + + + + + Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells. + GOC:ai + GOC:dgf + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. + amine transmembrane transporter activity + + + + + Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. + GOC:mtg_transport + ISBN:0198506732 + ISBN:0815340729 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the directed movement of lipids into, out of or within a cell, or between cells. + Reactome:R-HSA-1369028 + Reactome:R-HSA-1369052 + Reactome:R-HSA-174786 + Reactome:R-HSA-5682285 + Reactome:R-HSA-5682311 + Reactome:R-HSA-5683672 + Reactome:R-HSA-5683714 + Reactome:R-HSA-5688397 + Reactome:R-HSA-6801250 + Reactome:R-HSA-8848053 + Reactome:R-HSA-8866329 + lipid transporter activity + + + + + Enables the directed movement of lipids into, out of or within a cell, or between cells. + GOC:ai + + + + + Reactome:R-HSA-1369028 + ABCAs mediate lipid efflux + + + + + Reactome:R-HSA-1369052 + ABCAs mediate lipid influx + + + + + Reactome:R-HSA-174786 + ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex + + + + + Reactome:R-HSA-5682285 + ABCA12 transports lipids from cytosol to extracellular region + + + + + Reactome:R-HSA-5682311 + Defective ABCA12 does not transport lipids from cytosol to extracellular region + + + + + Reactome:R-HSA-5683672 + Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body + + + + + Reactome:R-HSA-5683714 + ABCA3 transports PC, PG from ER membrane to lamellar body + + + + + Reactome:R-HSA-5688397 + Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body + + + + + Reactome:R-HSA-6801250 + TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane + + + + + Reactome:R-HSA-8848053 + ABCA5 transports CHOL from lysosomal lumen to cytosol + + + + + Reactome:R-HSA-8866329 + MTTP lipidates APOB-100, forming a pre-VLDL + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage. + organic acid transmembrane transporter activity + + + + + Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. + Reactome:R-HSA-499981 + Reactome:R-HSA-5653873 + glucose transmembrane transporter activity + + + + + Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. + GOC:ai + GOC:mtg_transport + ISBN:0815340729 + + + + + Reactome:R-HSA-499981 + Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 + + + + + Reactome:R-HSA-5653873 + SLC2A1 tetramer transports Glc from cytosol to Golgi lumen + @@ -25573,8 +36569,17 @@ + A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). + NIF_Subcellular:sao1337158144 + Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. cellular_component + + + + A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). + GOC:pdt + @@ -25582,8 +36587,17 @@ + The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. + Wikipedia:Extracellular + Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. extracellular region + + + + The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. + GOC:go_curators + @@ -25597,8 +36611,15 @@ + A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. fibrinogen complex + + + + A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. + ISBN:0198547684 + @@ -25618,8 +36639,20 @@ + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. + Wikipedia:Collagen collagen trimer + + + + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. + GOC:dos + GOC:mah + ISBN:0721639976 + PMID:19693541 + PMID:21421911 + @@ -25645,8 +36678,17 @@ + Any triple helical collagen trimer that forms fibrils. fibrillar collagen trimer + + + + Any triple helical collagen trimer that forms fibrils. + GOC:mah + ISBN:0721639976 + PMID:21421911 + @@ -25654,8 +36696,16 @@ + A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. + Wikipedia:Collagen_type_II collagen type II trimer + + + + A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. + ISBN:0721639976 + @@ -25664,8 +36714,18 @@ + A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. + Wikipedia:Collagen_type_IV collagen type IV trimer + + + + A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. + ISBN:0721639976 + PMID:19693541 + PMID:21421911 + @@ -25673,8 +36733,18 @@ + A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. + Wikipedia:Basement_membrane + Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. basement membrane + + + + A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. + ISBN:0198547684 + PMID:22505934 + @@ -25688,8 +36758,17 @@ + That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. + NIF_Subcellular:sao1425028079 + Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. extracellular space + + + + That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. + ISBN:0198547684 + @@ -25703,8 +36782,16 @@ + A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. + Wikipedia:Intracellular intracellular anatomical structure + + + + A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. + ISBN:0198506732 + @@ -25731,8 +36818,17 @@ + A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. + NIF_Subcellular:sao1702920020 + Wikipedia:Cell_nucleus nucleus + + + + A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. + GOC:go_curators + @@ -25752,8 +36848,16 @@ + The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). + Wikipedia:Nuclear_envelope nuclear envelope + + + + The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). + ISBN:0198547684 + @@ -25785,8 +36889,16 @@ + The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. + NIF_Subcellular:sao1617136075 nuclear outer membrane + + + + The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. + ISBN:0198547684 + @@ -25794,8 +36906,17 @@ + A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. + Wikipedia:Chromosome + Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. chromosome + + + + A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. + ISBN:0198547684 + @@ -25809,8 +36930,17 @@ + A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. + NIF_Subcellular:sao1820400233 + Wikipedia:Nucleolus nucleolus + + + + A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. + ISBN:0198506732 + @@ -25824,8 +36954,16 @@ + The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + Wikipedia:Cytoplasm cytoplasm + + + + The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + ISBN:0198547684 + @@ -25859,8 +36997,18 @@ + A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. + NIF_Subcellular:sao585356902 + Wikipedia:Lysosome lysosome + + + + A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. + GOC:mah + ISBN:0198506732 + @@ -25917,8 +37065,15 @@ + The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. lysosomal membrane + + + + The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. + GOC:ai + @@ -25926,8 +37081,17 @@ + A lysosome before it has fused with a vesicle or vacuole. + NIF_Subcellular:sao1140587416 primary lysosome + + + + A lysosome before it has fused with a vesicle or vacuole. + GOC:jl + ISBN:0815316194 + @@ -25941,8 +37105,17 @@ + A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. + Wikipedia:Vacuole vacuole + + + + A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. + GOC:mtg_sensu + ISBN:0198506732 + @@ -25973,8 +37146,15 @@ + The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. vacuolar membrane + + + + The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. + GOC:ai + @@ -25999,8 +37179,15 @@ + The volume enclosed within the vacuolar membrane. vacuolar lumen + + + + The volume enclosed within the vacuolar membrane. + ISBN:0198506732 + @@ -26032,8 +37219,18 @@ + A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. + NIF_Subcellular:sao451912436 + Wikipedia:Golgi_apparatus + Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. Golgi apparatus + + + + A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. + ISBN:0198506732 + @@ -26041,8 +37238,17 @@ + Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. + NIF_Subcellular:sao819927218 + Note that this definition includes vesicles that are transiently associated with the Golgi. Golgi-associated vesicle + + + + Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. + GOC:mah + @@ -26068,8 +37274,17 @@ + An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. + NIF_Subcellular:sao1429207766 + Wikipedia:Ribosome ribosome + + + + An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. + ISBN:0198506732 + @@ -26077,8 +37292,18 @@ + A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. + Wikipedia:Cytoskeleton cytoskeleton + + + + A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. + GOC:mah + PMID:16959967 + PMID:27419875 + @@ -26092,8 +37317,17 @@ + Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. + NIF_Subcellular:sao1846835077 + Wikipedia:Microtubule microtubule + + + + Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. + ISBN:0879693568 + @@ -26118,8 +37352,16 @@ + A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. axonemal microtubule + + + + A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. + GOC:cilia + ISBN:0815316194 + @@ -26144,8 +37386,15 @@ + Any microtubule in the nucleus of a cell. nuclear microtubule + + + + Any microtubule in the nucleus of a cell. + GOC:mah + @@ -26170,8 +37419,15 @@ + Any microtubule in the cytoplasm of a cell. cytoplasmic microtubule + + + + Any microtubule in the cytoplasm of a cell. + GOC:mah + @@ -26185,8 +37441,20 @@ + A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. + FMA:63850 + NIF_Subcellular:sao1588493326 + Wikipedia:Actin actin filament + + + + A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. + GOC:mah + ISBN:0198506732 + PMID:10666339 + @@ -26200,8 +37468,17 @@ + The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. + NIF_Subcellular:sao1663586795 + Wikipedia:Cell_membrane plasma membrane + + + + The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. + ISBN:0716731363 + @@ -26247,8 +37524,18 @@ + Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. + NIF_Subcellular:sao671419673 + Wikipedia:Microvillus + Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. microvillus + + + + Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. + ISBN:0815316194 + @@ -26256,8 +37543,22 @@ + A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. + NIF_Subcellular:sao1922892319 cell-cell junction + + + + A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. + GOC:aruk + GOC:bc + GOC:dgh + GOC:hb + GOC:mah + PMID:21422226 + PMID:28096264 + @@ -26440,8 +37741,26 @@ + A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. + FMA:67181 + NIF_Subcellular:sao787716553 + Wikipedia:Cilium + Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. cilium + + + + A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. + GOC:cilia + GOC:curators + GOC:kmv + GOC:vw + ISBN:0198547684 + PMID:16824949 + PMID:17009929 + PMID:20144998 + @@ -26467,8 +37786,19 @@ + The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. + Wikipedia:Axoneme + Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. axoneme + + + + The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. + GOC:bf + GOC:cilia + ISBN:0198547684 + @@ -26493,8 +37823,17 @@ + The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. + Wikipedia:Cell_cortex cell cortex + + + + The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. + GOC:mah + ISBN:0815316194 + @@ -26519,8 +37858,17 @@ + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + Wikipedia:Carbohydrate_metabolism carbohydrate metabolic process + + + + The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + GOC:mah + ISBN:0198506732 + @@ -26545,8 +37893,257 @@ + The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. polysaccharide metabolic process + + + + The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + ISBN:0198547684 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. + glycogen metabolic process + + + + + The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + MetaCyc:GLYCOGENSYNTH-PWY + MetaCyc:PWY-5067 + MetaCyc:PWY-7900 + glycogen biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + regulation of glycogen biosynthetic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + MetaCyc:GLYCOCAT-PWY + MetaCyc:PWY-5941 + MetaCyc:PWY-7662 + glycogen catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + regulation of glycogen catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. + glucose metabolic process + + + + + The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. + glucose catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. + GOC:ai + @@ -26571,8 +38168,133 @@ + The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. glycosaminoglycan biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. + ISBN:0192800981 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. + glycosaminoglycan catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. + ISBN:0192800981 + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. + organic acid metabolic process + + + + + The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. + ISBN:0198506732 + + + + + + + + + The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. + generation of precursor metabolites and energy + + + + + The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. + MetaCyc:GLUCONEO-PWY + Wikipedia:Gluconeogenesis + gluconeogenesis + + + + + The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. + MetaCyc:GLUCONEO-PWY + @@ -26597,8 +38319,64 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. regulation of carbohydrate metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. + regulation of gluconeogenesis + + + + + Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. + GOC:go_curators + + + + + + + + + The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. + energy reserve metabolic process + + + + + The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. + GOC:mah + @@ -26623,8 +38401,15 @@ + Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. nucleobase-containing compound metabolic process + + + + Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:ai + @@ -26649,8 +38434,95 @@ + Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. DNA metabolic process + + + + Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. + DNA catabolic process + + + + + The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. + GOC:go_curators + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. + DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). + apoptotic DNA fragmentation + + + + + The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. + GOC:dph + GOC:mah + GOC:mtg_apoptosis + GOC:tb + ISBN:0721639976 + PMID:15723341 + PMID:23379520 + @@ -26675,8 +38547,48 @@ + The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. chromatin organization + + + + The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. + PMID:20404130 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. + RNA catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. + ISBN:0198506732 + @@ -26684,8 +38596,15 @@ + A process in which RNA is transported to, or maintained in, a specific location. RNA localization + + + + A process in which RNA is transported to, or maintained in, a specific location. + GOC:ai + @@ -26739,8 +38658,16 @@ + The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. + Wikipedia:Translation_(genetics) translation + + + + The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. + GOC:go_curators + @@ -26760,8 +38687,15 @@ + The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. translational initiation + + + + The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. + ISBN:019879276X + @@ -26775,8 +38709,15 @@ + The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. translational elongation + + + + The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. + GOC:ems + @@ -26790,8 +38731,16 @@ + The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). translational termination + + + + The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). + GOC:hjd + ISBN:019879276X + @@ -26817,8 +38766,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. regulation of translation + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. + GOC:isa_complete + @@ -26843,8 +38799,15 @@ + Any process that modulates the frequency, rate or extent of translational initiation. regulation of translational initiation + + + + Any process that modulates the frequency, rate or extent of translational initiation. + GOC:go_curators + @@ -26869,8 +38832,15 @@ + Any process that modulates the frequency, rate, extent or accuracy of translational elongation. regulation of translational elongation + + + + Any process that modulates the frequency, rate, extent or accuracy of translational elongation. + GOC:go_curators + @@ -26896,8 +38866,49 @@ + Any process that modulates the frequency, rate or extent of translational termination. regulation of translational termination + + + + Any process that modulates the frequency, rate or extent of translational termination. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + glycoprotein catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:go_curators + ISBN:0198506732 + @@ -26922,8 +38933,15 @@ + The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. peptide metabolic process + + + + The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. + GOC:go_curators + @@ -26931,8 +38949,16 @@ + The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. biogenic amine metabolic process + + + + The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. + GOC:jl + ISBN:0395825172 + @@ -26958,8 +38984,16 @@ + The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. catecholamine metabolic process + + + + The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:jl + ISBN:0198506732 + @@ -26984,8 +39018,132 @@ + The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. + Wikipedia:Lipid_metabolism lipid metabolic process + + + + The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. + GOC:ma + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. + Wikipedia:Steroid_metabolisms#Steroid_biosynthesis + steroid biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. + bile acid biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + steroid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:go_curators + @@ -26993,8 +39151,19 @@ + The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. + Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. transport + + + + The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. + GOC:dos + GOC:dph + GOC:jl + GOC:mah + @@ -27019,8 +39188,15 @@ + The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. monoatomic ion transport + + + + The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + GOC:ai + @@ -27045,8 +39221,15 @@ + The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. serotonin transport + + + + The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. + GOC:ai + @@ -27071,8 +39254,15 @@ + The transport of substances that occurs outside cells. extracellular transport + + + + The transport of substances that occurs outside cells. + GOC:go_curators + @@ -27103,8 +39293,48 @@ + The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. lipid transport + + + + The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + intracellular monoatomic ion homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + GOC:mah + @@ -27134,8 +39364,15 @@ + The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. intracellular protein transport + + + + The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. + GOC:mah + @@ -27167,8 +39404,18 @@ + A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. + Wikipedia:Exocytosis exocytosis + + + + A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. + GOC:mah + ISBN:0716731363 + PMID:22323285 + @@ -27176,8 +39423,16 @@ + The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. post-Golgi vesicle-mediated transport + + + + The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. + GOC:ai + GOC:mah + @@ -27207,8 +39462,15 @@ + The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. Golgi to plasma membrane transport + + + + The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. + ISBN:0716731363 + @@ -27248,8 +39510,15 @@ + The directed movement of substances from the Golgi to the vacuole. Golgi to vacuole transport + + + + The directed movement of substances from the Golgi to the vacuole. + GOC:ai + @@ -27276,8 +39545,19 @@ + A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle. + Wikipedia:Endocytosis endocytosis + + + + A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle. + GOC:mah + ISBN:0198506732 + ISBN:0716731363 + Wikipedia:Endocytosis + @@ -27292,8 +39572,16 @@ + The evagination of a membrane, resulting in formation of a vesicle. vesicle budding from membrane + + + + The evagination of a membrane, resulting in formation of a vesicle. + GOC:jid + GOC:tb + @@ -27313,8 +39601,16 @@ + The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. vesicle targeting + + + + The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. + GOC:mah + PMID:17335816 + @@ -27346,8 +39642,15 @@ + Fusion of the membrane of a transport vesicle with its target membrane. vesicle fusion + + + + Fusion of the membrane of a transport vesicle with its target membrane. + GOC:jid + @@ -27381,8 +39684,16 @@ + A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. + Wikipedia:Phagocytosis phagocytosis + + + + A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. + ISBN:0198506732 + @@ -27466,8 +39777,24 @@ + A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. + Wikipedia:Apoptosis apoptotic process + + + + A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. + GOC:cjm + GOC:dhl + GOC:ecd + GOC:go_curators + GOC:mtg_apoptosis + GOC:tb + ISBN:0198506732 + PMID:18846107 + PMID:21494263 + @@ -27492,8 +39819,18 @@ + The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. cellular component disassembly involved in execution phase of apoptosis + + + + The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. + GOC:dph + GOC:mah + GOC:mtg_apoptosis + GOC:tb + @@ -27501,8 +39838,16 @@ + Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage. inflammatory cell apoptotic process + + + + Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage. + GOC:jl + GOC:mtg_apoptosis + @@ -27516,8 +39861,16 @@ + The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). + Wikipedia:Chemotaxis chemotaxis + + + + The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). + ISBN:0198506732 + @@ -27531,8 +39884,18 @@ + A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. + Wikipedia:Muscle_contraction muscle contraction + + + + A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. + GOC:ef + GOC:mtg_muscle + ISBN:0198506732 + @@ -27557,8 +39920,15 @@ + Any process that modulates the frequency, rate or extent of muscle contraction. regulation of muscle contraction + + + + Any process that modulates the frequency, rate or extent of muscle contraction. + GOC:go_curators + @@ -27583,8 +39953,18 @@ + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. smooth muscle contraction + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. + GOC:ef + GOC:jl + GOC:mtg_muscle + ISBN:0198506732 + @@ -27609,8 +39989,15 @@ + Any process that modulates the frequency, rate or extent of smooth muscle contraction. regulation of smooth muscle contraction + + + + Any process that modulates the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators + @@ -27624,8 +40011,17 @@ + A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. striated muscle contraction + + + + A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. + GOC:jl + GOC:mtg_muscle + ISBN:0198506732 + @@ -27650,8 +40046,15 @@ + Any process that modulates the frequency, rate or extent of striated muscle contraction. regulation of striated muscle contraction + + + + Any process that modulates the frequency, rate or extent of striated muscle contraction. + GOC:go_curators + @@ -27677,8 +40080,15 @@ + The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. syncytium formation + + + + The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. + ISBN:0198506732 + @@ -27686,8 +40096,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to stress + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + GOC:mah + @@ -27695,8 +40113,15 @@ + Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. defense response + + + + Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. + GOC:go_curators + @@ -27716,8 +40141,17 @@ + The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. + Wikipedia:Inflammation inflammatory response + + + + The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. + GO_REF:0000022 + ISBN:0198506732 + @@ -27726,8 +40160,16 @@ + Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. immune response + + + + Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. + GOC:add + GO_REF:0000022 + @@ -27752,8 +40194,16 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. organelle organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + GOC:mah + @@ -27778,8 +40228,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. nucleus organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. + GOC:dph + GOC:ems + GOC:jl + GOC:mah + @@ -27816,8 +40276,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. nuclear envelope organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. + GOC:dph + GOC:ems + GOC:jl + GOC:mah + @@ -27842,8 +40312,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus. nucleolus organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus. + GOC:dph + GOC:jid + GOC:jl + GOC:mah + @@ -27874,8 +40354,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. plasma membrane organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. + GOC:dph + GOC:jl + GOC:mah + @@ -27900,8 +40389,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. + GOC:dph + GOC:jl + GOC:mah + @@ -27932,8 +40430,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. actin filament organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. + GOC:mah + @@ -27958,8 +40463,15 @@ + Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. microtubule-based process + + + + Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. + GOC:mah + @@ -27967,8 +40479,16 @@ + A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. microtubule-based movement + + + + A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. + GOC:cjm + ISBN:0815316194 + @@ -27994,8 +40514,15 @@ + The removal of tubulin heterodimers from one or both ends of a microtubule. microtubule depolymerization + + + + The removal of tubulin heterodimers from one or both ends of a microtubule. + ISBN:0815316194 + @@ -28009,8 +40536,18 @@ + The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). + Wikipedia:Microtubule_nucleation microtubule nucleation + + + + The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). + GOC:go_curators + ISBN:0815316194 + PMID:12517712 + @@ -28037,8 +40574,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. negative regulation of microtubule depolymerization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. + GOC:mah + ISBN:0815316194 + @@ -28065,8 +40610,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme. negative regulation of axonemal microtubule depolymerization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme. + GOC:dph + GOC:mah + @@ -28091,8 +40644,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. cytoplasm organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + GOC:curators + GOC:dph + GOC:jl + GOC:mah + @@ -28123,8 +40686,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. Golgi organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. + GOC:dph + GOC:jl + GOC:mah + @@ -28149,8 +40721,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. vacuole organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. + GOC:mah + @@ -28175,8 +40754,49 @@ + The directed movement of substances into, out of or within a vacuole. vacuolar transport + + + + The directed movement of substances into, out of or within a vacuole. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. + protein catabolic process in the vacuole + + + + + The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. + GOC:mah + GOC:vw + @@ -28227,8 +40847,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. lysosome organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. + GOC:mah + @@ -28279,8 +40906,15 @@ + The directed movement of substances into, out of or within a lysosome. lysosomal transport + + + + The directed movement of substances into, out of or within a lysosome. + GOC:ai + @@ -28305,8 +40939,15 @@ + The aggregation, arrangement and bonding together of a set of components to form a junction between cells. cell-cell junction assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a junction between cells. + GOC:ai + @@ -28314,8 +40955,17 @@ + The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. + Wikipedia:Cell_cycle cell cycle + + + + The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. + GOC:go_curators + GOC:mtg_cell_cycle + @@ -28323,8 +40973,19 @@ + The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. + Wikipedia:Chromosome_segregation chromosome segregation + + + + The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. + GOC:jl + GOC:mah + GOC:mtg_cell_cycle + GOC:vw + @@ -28350,8 +41011,16 @@ + The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. mitotic chromosome condensation + + + + The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. + GOC:mah + ISBN:0815316194 + @@ -28371,8 +41040,16 @@ + The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis. mitotic nuclear membrane disassembly + + + + The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis. + GOC:bf + PMID:32848252 + @@ -28399,8 +41076,15 @@ + Any process that modulates the frequency, rate or extent of mitosis. regulation of mitotic nuclear division + + + + Any process that modulates the frequency, rate or extent of mitosis. + GOC:go_curators + @@ -28421,8 +41105,15 @@ + The directed movement of the nucleus to a specific location within a cell. nuclear migration + + + + The directed movement of the nucleus to a specific location within a cell. + GOC:ai + @@ -28430,8 +41121,19 @@ + A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell. + Wikipedia:Mitosis#Endomitosis + Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins. endomitotic cell cycle + + + + A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell. + GOC:curators + GOC:dos + GOC:expert_vm + @@ -28486,8 +41188,19 @@ + A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. + Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. female meiotic nuclear division + + + + A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. + GOC:dph + GOC:ems + GOC:mah + GOC:vw + @@ -28495,8 +41208,16 @@ + Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + Wikipedia:Cell_signaling cell communication + + + + Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:mah + @@ -28504,8 +41225,17 @@ + The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. + Wikipedia:Cell_adhesion cell adhesion + + + + The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. + GOC:hb + GOC:pf + @@ -28548,8 +41278,15 @@ + The attachment of a leukocyte to another cell via adhesion molecules. leukocyte cell-cell adhesion + + + + The attachment of a leukocyte to another cell via adhesion molecules. + GOC:go_curators + @@ -28575,8 +41312,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. negative regulation of cell adhesion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. + GOC:go_curators + @@ -28584,8 +41328,15 @@ + Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. establishment or maintenance of cell polarity + + + + Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. + GOC:mah + @@ -28612,8 +41363,18 @@ + The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. + Wikipedia:Signal_transduction + Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. signal transduction + + + + The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. + GOC:go_curators + GOC:mtg_signaling_feb11 + @@ -28622,8 +41383,16 @@ + Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. cell-cell signaling + + + + Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. + GOC:dos + GOC:mah + @@ -28637,8 +41406,17 @@ + The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. + Wikipedia:Neurotransmission chemical synaptic transmission + + + + The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. + GOC:jl + MeSH:D009435 + @@ -28664,8 +41442,19 @@ + The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + Note that this term was 'developmental process'. multicellular organism development + + + + The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:dph + GOC:ems + GOC:isa_complete + GOC:tb + @@ -28679,8 +41468,16 @@ + The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. gamete generation + + + + The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. + GOC:ems + GOC:mtg_sensu + @@ -28713,8 +41510,15 @@ + The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. germ cell development + + + + The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. + GOC:go_curators + @@ -28722,8 +41526,16 @@ + Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. female gamete generation + + + + Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. + GOC:dph + ISBN:0198506732 + @@ -28750,8 +41562,16 @@ + Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster. germarium-derived egg chamber formation + + + + Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster. + GOC:mtg_sensu + ISBN:0879694238 + @@ -28783,8 +41603,19 @@ + The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster. oocyte construction + + + + The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster. + GOC:dph + GOC:ems + GOC:mtg_sensu + GOC:tb + ISBN:0198506732 + @@ -28830,8 +41661,16 @@ + The union of male and female gametes to form a zygote. single fertilization + + + + The union of male and female gametes to form a zygote. + GOC:ems + GOC:mtg_sensu + @@ -28862,8 +41701,17 @@ + The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm. + Wikipedia:Egg_activation egg activation + + + + The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm. + GOC:bf + PMID:9630751 + @@ -28888,8 +41736,17 @@ + Any process that modulates the rate or extent of progress through the mitotic cell cycle. regulation of mitotic cell cycle + + + + Any process that modulates the rate or extent of progress through the mitotic cell cycle. + GOC:dph + GOC:go_curators + GOC:tb + @@ -28898,8 +41755,16 @@ + The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. blastoderm segmentation + + + + The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. + ISBN:0879694238 + http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm + @@ -28925,8 +41790,17 @@ + A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + Wikipedia:Gastrulation gastrulation + + + + A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + GOC:curators + ISBN:9780878933846 + @@ -28940,8 +41814,17 @@ + Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. pattern specification process + + + + Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. + GOC:go_curators + GOC:isa_complete + ISBN:0521436125 + @@ -28966,8 +41849,16 @@ + The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. ectoderm development + + + + The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. + GOC:dph + GOC:tb + @@ -28992,8 +41883,15 @@ + The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. nervous system development + + + + The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. + GOC:dgh + @@ -29036,8 +41934,17 @@ + The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. neuroblast proliferation + + + + The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. + GOC:ai + GOC:mtg_sensu + GOC:sart + @@ -29064,8 +41971,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. negative regulation of neuroblast proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. + GOC:ai + @@ -29102,8 +42016,16 @@ + A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. neuroblast activation + + + + A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. + GOC:go_curators + GOC:mtg_sensu + @@ -29134,8 +42056,16 @@ + The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). + Wikipedia:Synaptogenesis synapse assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). + GOC:mah + @@ -29166,8 +42096,18 @@ + The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. + Wikipedia:Neural_development central nervous system development + + + + The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. + GOC:bf + GOC:jid + ISBN:0582227089 + @@ -29204,8 +42144,18 @@ + The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). brain development + + + + The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). + GOC:dph + GOC:jid + GOC:tb + UBERON:0000955 + @@ -29236,8 +42186,16 @@ + The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. peripheral nervous system development + + + + The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. + GOC:go_curators + UBERON:0000010 + @@ -29262,8 +42220,15 @@ + The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. sensory organ development + + + + The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. + GOC:go_curators + @@ -29294,8 +42259,15 @@ + The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm. ectodermal digestive tract development + + + + The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm. + GOC:curators + @@ -29326,8 +42298,60 @@ + The process in which the anatomical structures of the foregut are generated and organized. foregut morphogenesis + + + + The process in which the anatomical structures of the foregut are generated and organized. + GOC:jid + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the anatomical structures of the hindgut are generated and organized. + hindgut morphogenesis + + + + + The process in which the anatomical structures of the hindgut are generated and organized. + GOC:jid + @@ -29352,8 +42376,50 @@ + The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. endoderm development + + + + The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. + midgut development + + + + + The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. + GOC:jid + UBERON:0001045 + @@ -29378,8 +42444,16 @@ + The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. mesoderm development + + + + The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. + GOC:dph + GOC:tb + @@ -29412,8 +42486,15 @@ + The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. gonadal mesoderm development + + + + The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. + GOC:ai + @@ -29444,9 +42525,17 @@ - + The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + Wikipedia:Heart_development heart development + + + + The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. + GOC:jid + UBERON:0000948 + @@ -29472,8 +42561,16 @@ + The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. muscle organ development + + + + The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. + GOC:jid + ISBN:0198506732 + @@ -29504,8 +42601,15 @@ + The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. skeletal muscle tissue development + + + + The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. + GOC:mtg_muscle + @@ -29530,8 +42634,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. neuromuscular junction development + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. + GOC:mtg_OBO2OWL_2013 + @@ -29539,8 +42650,16 @@ + The establishment of the sex of an organism by physical differentiation. + Wikipedia:Sexual_differentiation sex differentiation + + + + The establishment of the sex of an organism by physical differentiation. + GOC:ai + @@ -29561,8 +42680,16 @@ + The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. + Wikipedia:Gestation female pregnancy + + + + The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. + ISBN:0192800825 + @@ -29582,8 +42709,16 @@ + Attachment of the blastocyst to the uterine lining. embryo implantation + + + + Attachment of the blastocyst to the uterine lining. + GOC:isa_complete + PMID:10882512 + @@ -29591,8 +42726,15 @@ + The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. respiratory gaseous exchange by respiratory system + + + + The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. + ISBN:0198506732 + @@ -29600,8 +42742,54 @@ + The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + Wikipedia:Digestion digestion + + + + The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:isa_complete + ISBN:0198506732 + + + + + + + + + The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. + Wikipedia:Excretion + excretion + + + + + The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. + ISBN:0192801023 + + + + + + + + + + The controlled release of a fluid by a cell or tissue in an animal. + body fluid secretion + + + + + The controlled release of a fluid by a cell or tissue in an animal. + GOC:ai + GOC:dph + GOC:mah + GOC:tb + @@ -29609,8 +42797,17 @@ + The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + Wikipedia:Perception sensory perception + + + + The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + GOC:dph + @@ -29618,8 +42815,16 @@ + The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. + Wikipedia:Visual_perception visual perception + + + + The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. + GOC:ai + @@ -29627,8 +42832,16 @@ + The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. + Wikipedia:Hearing_(sense) sensory perception of sound + + + + The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. + GOC:ai + @@ -29636,8 +42849,72 @@ + The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. sensory perception of chemical stimulus + + + + The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. + Wikipedia:Behavior + 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. +2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). + behavior + + + + + The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. + GOC:ems + GOC:jl + ISBN:0395448956 + PMID:20160973 + + + + + + + + + The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. + locomotory behavior + + + + + The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. + GOC:dph + @@ -29645,8 +42922,16 @@ + The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. blood circulation + + + + The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. + GOC:mtg_heart + ISBN:0192800825 + @@ -29671,8 +42956,17 @@ + Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. regulation of heart contraction + + + + Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. + GOC:dph + GOC:go_curators + GOC:tb + @@ -29697,8 +42991,20 @@ + The orderly movement of mesodermal cells from one site to another. mesodermal cell migration + + + + The orderly movement of mesodermal cells from one site to another. + GOC:ascb_2009 + GOC:dph + GOC:mah + GOC:sat + GOC:tb + PMID:25119047 + @@ -29727,8 +43033,16 @@ + The directed movement of organelles or molecules along microtubules in neuron projections. + Wikipedia:Axoplasmic_transport axo-dendritic transport + + + + The directed movement of organelles or molecules along microtubules in neuron projections. + ISBN:0815316194 + @@ -29753,8 +43067,15 @@ + Any process in which a protein is transported to, or maintained in, a specific location. protein localization + + + + Any process in which a protein is transported to, or maintained in, a specific location. + GOC:ai + @@ -29762,8 +43083,17 @@ + A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. + Wikipedia:Biological_process + Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. biological_process + + + + A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. + GOC:pdt + @@ -29772,8 +43102,87 @@ + The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. + Wikipedia:Metabolism + Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. metabolic process + + + + The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. + GOC:go_curators + ISBN:0198547684 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + Wikipedia:Steroid_metabolism + steroid metabolic process + + + + + The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + ISBN:0198547684 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + bile acid metabolic process + + + + + The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + GOC:go_curators + @@ -29781,8 +43190,18 @@ + Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). + This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. cell death + + + + Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). + GOC:mah + GOC:mtg_apoptosis + PMID:25236395 + @@ -29816,8 +43235,17 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. cell population proliferation + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + GOC:mah + GOC:mb + @@ -29849,8 +43277,15 @@ + Any process that activates or increases the rate or extent of cell proliferation. positive regulation of cell population proliferation + + + + Any process that activates or increases the rate or extent of cell proliferation. + GOC:go_curators + @@ -29882,8 +43317,193 @@ + Any process that stops, prevents or reduces the rate or extent of cell proliferation. negative regulation of cell population proliferation + + + + Any process that stops, prevents or reduces the rate or extent of cell proliferation. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a protein from one side of a membrane to the other. + Reactome:R-HSA-1268022 + Reactome:R-HSA-1299475 + Reactome:R-HSA-184269 + Reactome:R-HSA-3149434 + Reactome:R-HSA-5205661 + Reactome:R-HSA-5210943 + Reactome:R-HSA-5210947 + Reactome:R-HSA-5228406 + Reactome:R-HSA-5229111 + Reactome:R-HSA-5244404 + Reactome:R-HSA-5244428 + Reactome:R-HSA-5244506 + Reactome:R-HSA-5246514 + Reactome:R-HSA-5250616 + Reactome:R-HSA-5250884 + Reactome:R-HSA-5250972 + Reactome:R-HSA-5336420 + Reactome:R-HSA-9636375 + Reactome:R-HSA-9698930 + Reactome:R-HSA-9698933 + protein transmembrane transporter activity + + + + + Enables the transfer of a protein from one side of a membrane to the other. + GOC:jl + + + + + Reactome:R-HSA-1268022 + TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space + + + + + Reactome:R-HSA-1299475 + TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix + + + + + Reactome:R-HSA-184269 + Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex + + + + + Reactome:R-HSA-3149434 + Transport of GAG to the Plasma Membrane + + + + + Reactome:R-HSA-5205661 + Pink1 is recruited from the cytoplasm to the mitochondria + + + + + Reactome:R-HSA-5210943 + pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) + + + + + Reactome:R-HSA-5210947 + pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) + + + + + Reactome:R-HSA-5228406 + tetX HC transports tetX LC from target cell endosome membrane into cytosol + + + + + Reactome:R-HSA-5229111 + AP4 transports APP from trans-Golgi network to endosome lumen + + + + + Reactome:R-HSA-5244404 + botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5244428 + botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5244506 + botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5246514 + botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol + + + + + Reactome:R-HSA-5250616 + botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5250884 + botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5250972 + botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol + + + + + Reactome:R-HSA-5336420 + DT fragment B transports DT fragment A from target cell endosome membrane + + + + + Reactome:R-HSA-9636375 + SecA2 transports SapM from cytoplasm to cytosol + + + + + Reactome:R-HSA-9698930 + HCMV C Nucleocapsid Translocation + + + + + Reactome:R-HSA-9698933 + HCMV B Nucleocapsid Translocation + @@ -29926,8 +43546,16 @@ + The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. glial cell migration + + + + The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. + GOC:jl + GOC:mtg_sensu + @@ -29958,8 +43586,16 @@ + The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form. germ cell migration + + + + The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form. + GOC:bf + GOC:jl + @@ -29967,8 +43603,16 @@ + The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. + Wikipedia:Asymmetric_cell_division asymmetric cell division + + + + The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. + PMID:11672519 + @@ -30000,8 +43644,16 @@ + The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. gonad development + + + + The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. + GOC:ems + ISBN:0198506732 + @@ -30035,8 +43687,16 @@ + The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. epidermis development + + + + The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. + GOC:go_curators + UBERON:0001003 + @@ -30093,8 +43753,17 @@ + The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. female gonad development + + + + The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. + GOC:dph + GOC:jid + GOC:tb + @@ -30125,8 +43794,16 @@ + The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. photoreceptor cell morphogenesis + + + + The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. + GOC:jid + GOC:mah + @@ -30151,8 +43828,15 @@ + The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. lipid biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + GOC:go_curators + @@ -30177,8 +43861,103 @@ + The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. carbohydrate transport + + + + The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. + Note that this term is not intended for use in annotating lateral movement within membranes. + hexose transmembrane transport + + + + + The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. + GOC:vw + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. + Wikipedia:Catabolism + catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. + ISBN:0198547684 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + macromolecule catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + @@ -30186,8 +43965,17 @@ + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + Wikipedia:Anabolism biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + GOC:curators + ISBN:0198547684 + @@ -30213,8 +44001,16 @@ + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. macromolecule biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + @@ -30239,8 +44035,16 @@ + The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. glycoprotein metabolic process + + + + The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:go_curators + ISBN:0198506732 + @@ -30265,8 +44069,83 @@ + The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. glycoprotein biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:go_curators + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + glucan biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. + glucan catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. + GOC:go_curators + @@ -30287,8 +44166,15 @@ + The controlled release of proteins from a cell. protein secretion + + + + The controlled release of proteins from a cell. + GOC:ai + @@ -30313,8 +44199,16 @@ + The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. amine metabolic process + + + + The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + GOC:jl + ISBN:0198506732 + @@ -30339,8 +44233,50 @@ + The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. amine biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + amine catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. + GOC:jl + ISBN:0198506732 + @@ -30348,8 +44284,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. + Note that 'radiation' refers to electromagnetic radiation of any wavelength. response to radiation + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. + GOC:jl + Wikipedia:Electromagnetic_radiation + @@ -30374,8 +44319,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. response to light stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. + GOC:go_curators + ISBN:0582227089 + @@ -30416,8 +44369,17 @@ + The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). + Wikipedia:Fertilisation fertilization + + + + The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). + GOC:tb + ISBN:0198506732 + @@ -30426,8 +44388,15 @@ + The series of events in which an external stimulus is received by a cell and converted into a molecular signal. detection of external stimulus + + + + The series of events in which an external stimulus is received by a cell and converted into a molecular signal. + GOC:hb + @@ -30436,8 +44405,15 @@ + The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. detection of abiotic stimulus + + + + The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. + GOC:hb + @@ -30447,8 +44423,15 @@ + The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. detection of light stimulus + + + + The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. + GOC:go_curators + @@ -30456,8 +44439,16 @@ + The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. detection of visible light + + + + The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. + GOC:go_curators + ISBN:0198506732 + @@ -30471,8 +44462,15 @@ + The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. detection of chemical stimulus + + + + The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. + GOC:jl + @@ -30480,8 +44478,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to external stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. + GOC:hb + @@ -30489,8 +44495,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to biotic stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. + GOC:hb + @@ -30515,8 +44529,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. response to bacterium + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. + GOC:hb + @@ -30541,8 +44562,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. response to fungus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. + GOC:hb + @@ -30550,8 +44578,32 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to abiotic stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. + GOC:hb + + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. + response to toxic substance + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. + GOC:lr + @@ -30567,8 +44619,17 @@ + The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. + Wikipedia:Morphogenesis anatomical structure morphogenesis + + + + The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. + GOC:go_curators + ISBN:0521436125 + @@ -30593,8 +44654,16 @@ + The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. catechol-containing compound metabolic process + + + + The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. + GOC:sm + ISBN:0198547684 + @@ -30619,8 +44688,15 @@ + The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. catechol-containing compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. + GOC:go_curators + @@ -30628,8 +44704,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to endogenous stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. + GOC:sm + @@ -30689,8 +44773,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. response to hormone + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. + GOC:jl + @@ -30715,8 +44806,81 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. response to carbohydrate + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. + response to hexose + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. + response to glucose + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. + GOC:jl + @@ -30741,8 +44905,15 @@ + Any process that modulates the frequency, rate or extent of asymmetric cell division. regulation of asymmetric cell division + + + + Any process that modulates the frequency, rate or extent of asymmetric cell division. + GOC:lr + @@ -30767,8 +44938,18 @@ + The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + Wikipedia:Embryogenesis embryo development + + + + The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + GOC:go_curators + GOC:isa_complete + GOC:mtg_sensu + @@ -30782,8 +44963,15 @@ + The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. post-embryonic development + + + + The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. + GOC:go_curators + @@ -30803,8 +44991,17 @@ + The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. embryo development ending in birth or egg hatching + + + + The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. + GOC:go_curators + GOC:isa_complete + GOC:mtg_sensu + @@ -30818,8 +45015,16 @@ + The process that results in the patterns of cell differentiation that will arise in an embryo. embryonic pattern specification + + + + The process that results in the patterns of cell differentiation that will arise in an embryo. + GOC:go_curators + ISBN:0521436125 + @@ -30862,8 +45067,18 @@ + Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. animal organ morphogenesis + + + + Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:dgh + GOC:go_curators + ISBN:0471245208 + ISBN:0721662544 + @@ -31030,8 +45245,16 @@ + The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. + Wikipedia:Histogenesis tissue development + + + + The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. + ISBN:0471245208 + @@ -31056,8 +45279,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. regulation of biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators + @@ -31083,8 +45313,15 @@ + Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. negative regulation of biosynthetic process + + + + Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators + @@ -31110,8 +45347,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. positive regulation of biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. + GOC:go_curators + @@ -31137,8 +45381,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. negative regulation of metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators + @@ -31164,8 +45415,116 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. positive regulation of metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. + regulation of catabolic process + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + negative regulation of catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + positive regulation of catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. + GOC:go_curators + @@ -31196,8 +45555,19 @@ + The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. epidermal cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. + GOC:dph + GOC:go_curators + GOC:mtg_sensu + GOC:sdb_2009 + GOC:tb + @@ -31206,8 +45576,15 @@ + The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. hormone transport + + + + The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:tb + @@ -31215,8 +45592,18 @@ + The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. anterior/posterior pattern specification + + + + The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. + GOC:dph + GOC:go_curators + GOC:isa_complete + GOC:tb + @@ -31243,8 +45630,15 @@ + Any process that modulates the frequency, rate or extent of signal transduction. regulation of signal transduction + + + + Any process that modulates the frequency, rate or extent of signal transduction. + GOC:sm + @@ -31272,8 +45666,15 @@ + Any process that activates or increases the frequency, rate or extent of signal transduction. positive regulation of signal transduction + + + + Any process that activates or increases the frequency, rate or extent of signal transduction. + GOC:sm + @@ -31301,8 +45702,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. negative regulation of signal transduction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. + GOC:sm + @@ -31310,8 +45718,17 @@ + Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. cellular process + + + + Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:go_curators + GOC:isa_complete + @@ -31343,8 +45760,16 @@ + The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. oocyte differentiation + + + + The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. + GOC:go_curators + GOC:mtg_sensu + @@ -31387,8 +45812,16 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. glial cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. + GOC:go_curators + GOC:mtg_sensu + @@ -31414,8 +45847,15 @@ + The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. cardioblast differentiation + + + + The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. + GOC:go_curators + @@ -31435,8 +45875,15 @@ + Compaction of chromatin structure prior to meiosis in eukaryotic cells. meiotic chromosome condensation + + + + Compaction of chromatin structure prior to meiosis in eukaryotic cells. + PMID:10072401 + @@ -31461,8 +45908,15 @@ + The division of the zygote into two daughter cells that will adopt developmentally distinct potentials. zygote asymmetric cell division + + + + The division of the zygote into two daughter cells that will adopt developmentally distinct potentials. + GOC:tb + @@ -31494,8 +45948,17 @@ + The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. formation of animal organ boundary + + + + The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. + GOC:dph + GOC:isa_complete + PMID:9611175 + @@ -31520,8 +45983,16 @@ + The process in which the anatomical structures of the soma are generated and organized. body morphogenesis + + + + The process in which the anatomical structures of the soma are generated and organized. + GOC:ems + ISBN:0140512888 + @@ -31546,8 +46017,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to organonitrogen compound + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. + PMID:9869419 + @@ -31572,8 +46051,16 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. endomembrane system organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. + GOC:mah + GOC:sm + @@ -31581,8 +46068,15 @@ + The infolding of a membrane. membrane invagination + + + + The infolding of a membrane. + GOC:tb + @@ -31608,8 +46102,16 @@ + Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. regulation of cell fate commitment + + + + Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. + GOC:dph + GOC:tb + @@ -31635,8 +46137,16 @@ + Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. negative regulation of cell fate commitment + + + + Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. + GOC:dph + GOC:tb + @@ -31662,8 +46172,16 @@ + Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. positive regulation of cell fate commitment + + + + Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. + GOC:dph + GOC:tb + @@ -31688,8 +46206,16 @@ + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. mesenchymal cell proliferation + + + + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:dph + GOC:tb + @@ -31714,8 +46240,16 @@ + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. regulation of mesenchymal cell proliferation + + + + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:dph + GOC:tb + @@ -31723,8 +46257,18 @@ + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. + Wikipedia:Gene_expression gene expression + + + + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. + GOC:txnOH-2018 + PMID:25934543 + PMID:31580950 + @@ -31749,8 +46293,17 @@ + Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + Wikipedia:Regulation_of_gene_expression + This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. regulation of gene expression + + + + Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + GOC:txnOH-2018 + @@ -31776,8 +46329,16 @@ + Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. regulation of gastrulation + + + + Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. + GOC:dph + GOC:tb + @@ -31802,8 +46363,15 @@ + Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells. epidermal cell division + + + + Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells. + PMID:17450124 + @@ -31828,8 +46396,15 @@ + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis. regulation of epidermal cell division + + + + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis. + PMID:17450124 + @@ -31875,8 +46450,15 @@ + The movement of substances between cells. intercellular transport + + + + The movement of substances between cells. + GOC:dhl + @@ -31901,8 +46483,16 @@ + Any process that modulates the frequency, rate or extent of membrane disassembly. regulation of membrane disassembly + + + + Any process that modulates the frequency, rate or extent of membrane disassembly. + GOC:dph + GOC:tb + @@ -31928,8 +46518,16 @@ + Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. regulation of macromolecule biosynthetic process + + + + Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -31956,8 +46554,16 @@ + Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. positive regulation of macromolecule biosynthetic process + + + + Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -31984,8 +46590,16 @@ + Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. negative regulation of macromolecule biosynthetic process + + + + Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -32010,8 +46624,16 @@ + Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. regulation of glycoprotein biosynthetic process + + + + Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:dph + GOC:tb + @@ -32037,8 +46659,16 @@ + Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. positive regulation of glycoprotein biosynthetic process + + + + Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:dph + GOC:tb + @@ -32064,8 +46694,16 @@ + Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. negative regulation of glycoprotein biosynthetic process + + + + Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. + GOC:dph + GOC:tb + @@ -32090,8 +46728,121 @@ + Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. regulation of cell cycle process + + + + Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + regulation of cellular ketone metabolic process + + + + + Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. + regulation of ketone biosynthetic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells. + regulation of ketone catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells. + GOC:dph + GOC:tb + @@ -32116,8 +46867,17 @@ + Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. regulation of endothelial cell migration + + + + Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. + GOC:BHF + GOC:dph + GOC:tb + @@ -32143,8 +46903,17 @@ + Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. positive regulation of endothelial cell migration + + + + Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. + GOC:BHF + GOC:dph + GOC:tb + @@ -32170,8 +46939,17 @@ + Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. negative regulation of endothelial cell migration + + + + Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. + GOC:BHF + GOC:dph + GOC:tb + @@ -32197,8 +46975,16 @@ + Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. positive regulation of macromolecule metabolic process + + + + Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -32224,8 +47010,16 @@ + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. negative regulation of macromolecule metabolic process + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -32233,8 +47027,16 @@ + Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. post-transcriptional regulation of gene expression + + + + Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. + GOC:dph + GOC:tb + @@ -32260,8 +47062,16 @@ + Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. regulation of cardiac muscle hypertrophy + + + + Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. + GOC:dph + GOC:tb + @@ -32286,8 +47096,16 @@ + Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. regulation of cardiac muscle adaptation + + + + Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. + GOC:dph + GOC:tb + @@ -32313,8 +47131,17 @@ + Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. positive regulation of cardiac muscle hypertrophy + + + + Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. + GOC:BHF + GOC:dph + GOC:tb + @@ -32340,8 +47167,17 @@ + Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. negative regulation of cardiac muscle hypertrophy + + + + Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. + GOC:BHF + GOC:dph + GOC:tb + @@ -32367,8 +47203,17 @@ + Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. positive regulation of cardiac muscle adaptation + + + + Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. + GOC:BHF + GOC:dph + GOC:tb + @@ -32394,8 +47239,17 @@ + Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. negative regulation of cardiac muscle adaptation + + + + Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. + GOC:BHF + GOC:dph + GOC:tb + @@ -32421,8 +47275,18 @@ + The activation of endogenous cellular processes that result in the death of a cell as part of its development. + This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. programmed cell death involved in cell development + + + + The activation of endogenous cellular processes that result in the death of a cell as part of its development. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32448,8 +47312,15 @@ + Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). positive regulation of gene expression + + + + Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + GOC:txnOH-2018 + @@ -32475,8 +47346,16 @@ + Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. negative regulation of gene expression + + + + Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). + GOC:txnOH-2018 + @@ -32507,8 +47386,18 @@ + The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism. epithelial cell migration + + + + The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism. + GOC:BHF + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -32534,8 +47423,17 @@ + Any process that modulates the frequency, rate or extent of epithelial cell migration. regulation of epithelial cell migration + + + + Any process that modulates the frequency, rate or extent of epithelial cell migration. + GOC:BHF + GOC:dph + GOC:tb + @@ -32562,8 +47460,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. negative regulation of epithelial cell migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. + GOC:BHF + GOC:dph + GOC:tb + @@ -32589,8 +47496,17 @@ + Any process that activates or increases the frequency, rate or extent of epithelial cell migration. positive regulation of epithelial cell migration + + + + Any process that activates or increases the frequency, rate or extent of epithelial cell migration. + GOC:BHF + GOC:dph + GOC:tb + @@ -32616,8 +47532,16 @@ + Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. positive regulation of organelle organization + + + + Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + GOC:dph + GOC:tb + @@ -32643,8 +47567,16 @@ + Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. negative regulation of organelle organization + + + + Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + GOC:dph + GOC:tb + @@ -32669,8 +47601,16 @@ + Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. regulation of cell communication + + + + Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb + @@ -32696,8 +47636,16 @@ + Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. positive regulation of cell communication + + + + Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb + @@ -32723,8 +47671,16 @@ + Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. negative regulation of cell communication + + + + Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:dph + GOC:tb + @@ -32750,8 +47706,17 @@ + Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. negative regulation of muscle cell apoptotic process + + + + Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32788,8 +47753,18 @@ + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. muscle cell apoptotic process + + + + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. + CL:0000187 + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32814,8 +47789,18 @@ + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations. striated muscle cell apoptotic process + + + + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations. + CL:0000737 + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32840,8 +47825,18 @@ + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. cardiac muscle cell apoptotic process + + + + A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. + CL:0000746 + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32866,8 +47861,17 @@ + Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. regulation of muscle cell apoptotic process + + + + Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32893,8 +47897,17 @@ + Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. positive regulation of muscle cell apoptotic process + + + + Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32919,8 +47932,17 @@ + Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. regulation of striated muscle cell apoptotic process + + + + Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32946,8 +47968,17 @@ + Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. positive regulation of striated muscle cell apoptotic process + + + + Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -32973,8 +48004,19 @@ + Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. negative regulation of striated muscle cell apoptotic process + + + + Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. + GOC:BHF + GOC:dph + GOC:mtg_apoptosis + GOC:rl + GOC:tb + @@ -32999,8 +48041,17 @@ + Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. regulation of cardiac muscle cell apoptotic process + + + + Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -33026,8 +48077,17 @@ + Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. positive regulation of cardiac muscle cell apoptotic process + + + + Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. + GOC:dph + GOC:mtg_apoptosis + GOC:tb + @@ -33053,8 +48113,19 @@ + Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. negative regulation of cardiac muscle cell apoptotic process + + + + Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. + GOC:BHF + GOC:dph + GOC:mtg_apoptosis + GOC:rl + GOC:tb + @@ -33085,8 +48156,16 @@ + The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. ectodermal cell differentiation + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:dph + GOC:tb + @@ -33112,8 +48191,16 @@ + Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. negative regulation of norepinephrine secretion + + + + Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. + GOC:dph + GOC:tb + @@ -33139,8 +48226,87 @@ + Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. positive regulation of norepinephrine secretion + + + + Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + regulation of collagen catabolic process + + + + + Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + GOC:BHF + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + negative regulation of collagen catabolic process + + + + + Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + GOC:BHF + GOC:dph + GOC:tb + @@ -33165,8 +48331,16 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. regulation of collagen metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:dph + GOC:tb + @@ -33192,8 +48366,16 @@ + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. negative regulation of collagen metabolic process + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:dph + GOC:tb + @@ -33219,8 +48401,16 @@ + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. positive regulation of collagen metabolic process + + + + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:dph + GOC:tb + @@ -33245,8 +48435,17 @@ + Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. regulation of extracellular matrix disassembly + + + + Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. + GOC:BHF + GOC:dph + GOC:tb + @@ -33272,8 +48471,17 @@ + Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. negative regulation of extracellular matrix disassembly + + + + Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. + GOC:BHF + GOC:dph + GOC:tb + @@ -33298,8 +48506,17 @@ + Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. regulation of epithelial to mesenchymal transition + + + + Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. + GOC:BHF + GOC:dph + GOC:tb + @@ -33326,8 +48543,17 @@ + Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. positive regulation of epithelial to mesenchymal transition + + + + Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. + GOC:BHF + GOC:dph + GOC:tb + @@ -33354,8 +48580,17 @@ + Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. negative regulation of epithelial to mesenchymal transition + + + + Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. + GOC:BHF + GOC:dph + GOC:tb + @@ -33381,8 +48616,17 @@ + Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. positive regulation of cell development + + + + Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + GOC:BHF + GOC:dph + GOC:tb + @@ -33408,8 +48652,17 @@ + Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. negative regulation of cell development + + + + Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + GOC:BHF + GOC:dph + GOC:tb + @@ -33435,8 +48688,17 @@ + Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. regulation of macrophage chemotaxis + + + + Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. + GOC:BHF + GOC:dph + GOC:tb + @@ -33464,8 +48726,17 @@ + Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. positive regulation of macrophage chemotaxis + + + + Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. + GOC:BHF + GOC:dph + GOC:tb + @@ -33492,8 +48763,17 @@ + Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. negative regulation of macrophage chemotaxis + + + + Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. + GOC:BHF + GOC:dph + GOC:tb + @@ -33518,8 +48798,17 @@ + Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. fibroblast migration + + + + Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. + GOC:BHF + GOC:dph + GOC:tb + @@ -33544,8 +48833,16 @@ + Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. regulation of fibroblast migration + + + + Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. + GOC:dph + GOC:tb + @@ -33571,8 +48868,17 @@ + Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. positive regulation of fibroblast migration + + + + Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. + GOC:BHF + GOC:dph + GOC:tb + @@ -33598,8 +48904,16 @@ + Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. negative regulation of fibroblast migration + + + + Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. + GOC:dph + GOC:tb + @@ -33625,8 +48939,16 @@ + Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. positive regulation of cell morphogenesis + + + + Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. + GOC:dph + GOC:tb + @@ -33652,16 +48974,33 @@ + Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. negative regulation of cell morphogenesis + + + + Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. + GOC:dph + GOC:tb + + Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. regulation of hormone levels + + + + Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. + GOC:BHF + GOC:dph + GOC:tb + @@ -33681,8 +49020,16 @@ + The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. T cell chemotaxis + + + + The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. + GOC:dph + GOC:tb + @@ -33708,8 +49055,16 @@ + Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. regulation of T cell chemotaxis + + + + Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. + GOC:dph + GOC:tb + @@ -33736,8 +49091,123 @@ + Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. positive regulation of T cell chemotaxis + + + + Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. + GOC:BHF + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + regulation of glucose transmembrane transport + + + + + Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + positive regulation of glucose transmembrane transport + + + + + Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:BHF + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + negative regulation of glucose transmembrane transport + + + + + Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:BHF + GOC:dph + GOC:tb + @@ -33762,8 +49232,16 @@ + Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. regulation of myotube differentiation + + + + Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:dph + GOC:tb + @@ -33789,8 +49267,16 @@ + Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. positive regulation of myotube differentiation + + + + Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:dph + GOC:tb + @@ -33816,8 +49302,16 @@ + Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. negative regulation of myotube differentiation + + + + Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:dph + GOC:tb + @@ -33854,8 +49348,18 @@ + The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. retina layer formation + + + + The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. + GOC:ascb_2009 + GOC:dph + GOC:tb + PMID:1270266 + @@ -33880,8 +49384,157 @@ + Any process in which a lipid is transported to, or maintained in, a specific location. lipid localization + + + + Any process in which a lipid is transported to, or maintained in, a specific location. + GOC:BHF + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + positive regulation of steroid biosynthetic process + + + + + Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + negative regulation of steroid biosynthetic process + + + + + Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:BHF + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + regulation of glucose metabolic process + + + + + Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + GOC:BHF + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + positive regulation of glucose metabolic process + + + + + Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. + GOC:BHF + GOC:tb + @@ -33907,8 +49560,16 @@ + The cellular component assembly that is part of the initial shaping of the component during its developmental progression. cellular component assembly involved in morphogenesis + + + + The cellular component assembly that is part of the initial shaping of the component during its developmental progression. + GOC:dph + GOC:tb + @@ -33933,8 +49594,19 @@ + The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. macrophage cytokine production + + + + The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:BHF + GOC:dph + GOC:rl + GOC:tb + @@ -33959,8 +49631,16 @@ + Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. regulation of macrophage cytokine production + + + + Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:BHF + GOC:rl + @@ -33986,8 +49666,16 @@ + Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. negative regulation of macrophage cytokine production + + + + Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:BHF + GOC:rl + @@ -34013,8 +49701,16 @@ + Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization. regulation of cytoplasmic microtubule depolymerization + + + + Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization. + GOC:dph + GOC:tb + @@ -34040,8 +49736,16 @@ + The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule. cytoplasmic microtubule depolymerization + + + + The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule. + GOC:dph + GOC:tb + @@ -34067,8 +49771,50 @@ + Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. negative regulation of cell cycle process + + + + Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + regulation of glucan biosynthetic process + + + + + Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. + GOC:dph + GOC:tb + @@ -34093,8 +49839,16 @@ + Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. regulation of microtubule nucleation + + + + Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. + GOC:dph + GOC:tb + @@ -34121,8 +49875,17 @@ + The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. transport along microtubule + + + + The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. + GOC:dph + GOC:mah + GOC:tb + @@ -34147,8 +49910,16 @@ + Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). regulation of neuron projection development + + + + Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). + GOC:dph + GOC:tb + @@ -34174,8 +49945,16 @@ + Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). positive regulation of neuron projection development + + + + Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). + GOC:dph + GOC:tb + @@ -34201,8 +49980,16 @@ + Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). negative regulation of neuron projection development + + + + Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). + GOC:dph + GOC:tb + @@ -34227,8 +50014,18 @@ + A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. + Wikipedia:Programmed_cell_death + Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. programmed cell death + + + + A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. + GOC:lr + GOC:mtg_apoptosis + @@ -34254,8 +50051,16 @@ + A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. + Wikipedia:Endomembrane_system endomembrane system + + + + A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. + GOC:lh + @@ -34280,8 +50085,17 @@ + The lipid bilayer surrounding any membrane-bounded vesicle in the cell. + NIF_Subcellular:sao1153182838 vesicle membrane + + + + The lipid bilayer surrounding any membrane-bounded vesicle in the cell. + GOC:mah + GOC:vesicle + @@ -34312,8 +50126,16 @@ + The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. glial cell proliferation + + + + The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. + GOC:ef + ISBN:0878932585 + @@ -34338,8 +50160,15 @@ + Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. regulation of gliogenesis + + + + Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. + GOC:ef + @@ -34365,8 +50194,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. negative regulation of gliogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. + GOC:ef + @@ -34392,8 +50228,15 @@ + Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. positive regulation of gliogenesis + + + + Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. + GOC:ef + @@ -34424,8 +50267,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. neuroblast differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. + GOC:ef + ISBN:0878932585 + @@ -34456,8 +50307,16 @@ + The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron. neuroblast development + + + + The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron. + GOC:ef + ISBN:0878932585 + @@ -34471,8 +50330,17 @@ + The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. primary neural tube formation + + + + The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. + GOC:ef + ISBN:0878932585 + PMID:15327780 + @@ -34515,8 +50383,16 @@ + The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. neural rod formation + + + + The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. + GOC:dh + GOC:ef + @@ -34547,8 +50423,16 @@ + The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts. neural keel formation + + + + The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts. + GOC:dh + GOC:ef + @@ -34585,8 +50469,16 @@ + The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. notochord formation + + + + The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. + GOC:dh + GOC:ef + @@ -34618,8 +50510,16 @@ + The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. neural crest formation + + + + The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. + GOC:dh + GOC:ef + @@ -34650,8 +50550,16 @@ + The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. mesenchymal cell development + + + + The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:dh + GOC:ef + @@ -34682,8 +50590,16 @@ + The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. neural crest cell development + + + + The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:dh + GOC:ef + @@ -34709,8 +50625,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. neural crest cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. + GOC:dh + GOC:ef + @@ -34736,8 +50660,15 @@ + Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. regulation of neuron maturation + + + + Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. + GOC:ef + @@ -34763,8 +50694,15 @@ + Any process that activates or increases the frequency, rate or extent of neuron maturation. positive regulation of neuron maturation + + + + Any process that activates or increases the frequency, rate or extent of neuron maturation. + GOC:ef + @@ -34790,8 +50728,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation. negative regulation of neuron maturation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation. + GOC:ef + @@ -34816,8 +50761,15 @@ + Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. regulation of norepinephrine secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. + GOC:ef + @@ -34843,8 +50795,15 @@ + Any process that modulates the frequency, rate or extent of the regulated release of serotonin. regulation of serotonin secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + @@ -34871,8 +50830,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. negative regulation of serotonin secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + @@ -34899,8 +50865,15 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. positive regulation of serotonin secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. + GOC:ef + @@ -34925,8 +50898,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. response to amine + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. + GOC:ef + @@ -34951,8 +50931,17 @@ + The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. striated muscle tissue development + + + + The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. + CL:0000737 + GOC:dph + GOC:mtg_muscle + @@ -34977,8 +50966,15 @@ + Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. regulation of skeletal muscle adaptation + + + + Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. + GOC:mtg_muscle + @@ -34998,8 +50994,15 @@ + The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. skeletal muscle hypertrophy + + + + The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. + GOC:mtg_muscle + @@ -35025,8 +51028,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. negative regulation of muscle hypertrophy + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. + GOC:mtg_muscle + @@ -35052,8 +51062,15 @@ + Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. positive regulation of muscle hypertrophy + + + + Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. + GOC:mtg_muscle + @@ -35078,8 +51095,15 @@ + Any process that modulates the frequency, rate or extent of muscle hypertrophy. regulation of muscle hypertrophy + + + + Any process that modulates the frequency, rate or extent of muscle hypertrophy. + GOC:mtg_muscle + @@ -35106,8 +51130,15 @@ + Any process that activates or increases the frequency, rate or extent of muscle adaptation. positive regulation of muscle adaptation + + + + Any process that activates or increases the frequency, rate or extent of muscle adaptation. + GOC:mtg_muscle + @@ -35134,8 +51165,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. negative regulation of muscle adaptation + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. + GOC:mtg_muscle + @@ -35160,8 +51198,15 @@ + Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. smooth muscle adaptation + + + + Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. + GOC:mtg_muscle + @@ -35187,8 +51232,15 @@ + Any process that modulates the frequency, rate or extent of somitogenesis. regulation of somitogenesis + + + + Any process that modulates the frequency, rate or extent of somitogenesis. + GOC:mtg_muscle + @@ -35213,8 +51265,16 @@ + The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. muscle cell migration + + + + The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. + CL:0000187 + GOC:mtg_muscle + @@ -35239,8 +51299,69 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle contraction. regulation of skeletal muscle contraction + + + + Any process that modulates the frequency, rate or extent of skeletal muscle contraction. + GOC:ef + GOC:mtg_muscle + + + + + + + + + A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. + phasic smooth muscle contraction + + + + + A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. + GOC:mtg_muscle + + + + + + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. + intestine smooth muscle contraction + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. + GOC:mtg_muscle + MA:0001539 + MSH:D007422 + + + + + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract). + gastro-intestinal system smooth muscle contraction + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract). + GOC:mtg_muscle + MA:0001523 + MSH:D041981 + @@ -35265,8 +51386,17 @@ + The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. striated muscle cell proliferation + + + + The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. + CL:0000737 + GOC:ef + GOC:mtg_muscle + @@ -35291,8 +51421,17 @@ + The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. skeletal muscle cell proliferation + + + + The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. + CL:0000188 + GOC:ef + GOC:mtg_muscle + @@ -35317,8 +51456,17 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. regulation of skeletal muscle cell proliferation + + + + Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. + CL:0000188 + GOC:ef + GOC:mtg_muscle + @@ -35344,8 +51492,17 @@ + Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation. positive regulation of skeletal muscle cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation. + CL:0000188 + GOC:ef + GOC:mtg_muscle + @@ -35371,8 +51528,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation. negative regulation of skeletal muscle cell proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation. + CL:0000188 + GOC:ef + GOC:mtg_muscle + @@ -35398,8 +51564,17 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes. regulation of skeletal muscle contraction via regulation of action potential + + + + Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_muscle + @@ -35424,8 +51599,16 @@ + The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. skeletal myofibril assembly + + + + The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. + GOC:ef + GOC:mtg_muscle + @@ -35450,8 +51633,17 @@ + The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. myoblast division + + + + The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:ef + GOC:mtg_muscle + @@ -35476,8 +51668,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. response to stimulus involved in regulation of muscle adaptation + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. + GOC:ef + GOC:mtg_muscle + @@ -35502,8 +51702,15 @@ + The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. cardiac muscle adaptation + + + + The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. + GOC:mtg_muscle + @@ -35528,8 +51735,15 @@ + Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. striated muscle adaptation + + + + Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. + GOC:mtg_muscle + @@ -35549,8 +51763,15 @@ + The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy. smooth muscle hypertrophy + + + + The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy. + GOC:mtg_muscle + @@ -35564,8 +51785,16 @@ + The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. + Wikipedia:Muscle_hypertrophy muscle hypertrophy + + + + The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. + GOC:mtg_muscle + @@ -35590,8 +51819,15 @@ + The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. striated muscle hypertrophy + + + + The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. + GOC:mtg_muscle + @@ -35616,8 +51852,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. myotube differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:mtg_muscle + @@ -35648,8 +51891,15 @@ + The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. myotube cell development + + + + The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. + GOC:mtg_muscle + @@ -35674,8 +51924,16 @@ + The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism. smooth muscle cell migration + + + + The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism. + CL:0000192 + GOC:mtg_muscle + @@ -35700,8 +51958,16 @@ + Any process that modulates the frequency, rate or extent of smooth muscle cell migration. regulation of smooth muscle cell migration + + + + Any process that modulates the frequency, rate or extent of smooth muscle cell migration. + CL:0000192 + GOC:mtg_muscle + @@ -35727,8 +51993,16 @@ + Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. positive regulation of smooth muscle cell migration + + + + Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. + CL:0000192 + GOC:mtg_muscle + @@ -35754,8 +52028,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. negative regulation of smooth muscle cell migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. + CL:0000192 + GOC:mtg_muscle + @@ -35775,8 +52057,327 @@ + The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. protein transport + + + + The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of an ion from one side of a membrane to the other. + monoatomic ion transmembrane transporter activity + + + + + Enables the transfer of an ion from one side of a membrane to the other. + GOC:dgf + GOC:mtg_transport + ISBN:0815340729 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. + RHEA:28695 + Reactome:R-HSA-2752067 + bicarbonate transmembrane transporter activity + + + + + Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. + GOC:ai + + + + + Reactome:R-HSA-2752067 + BESTs transport cytosolic HCO3- to extracellular region + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + Reactome:R-HSA-194079 + Reactome:R-HSA-194083 + Reactome:R-HSA-194130 + Reactome:R-HSA-5661184 + Reactome:R-HSA-5661198 + Reactome:R-HSA-9733964 + bile acid transmembrane transporter activity + + + + + Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + GOC:ai + + + + + Reactome:R-HSA-194079 + SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol + + + + + Reactome:R-HSA-194083 + SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol + + + + + Reactome:R-HSA-194130 + Transport (influx) of bile salts and acids by OATP-A + + + + + Reactome:R-HSA-5661184 + Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) + + + + + Reactome:R-HSA-5661198 + Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) + + + + + Reactome:R-HSA-9733964 + SLC51A:SLC51B transports bile salts from cytosol to extracellular region + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of carbohydrate from one side of a membrane to the other. + carbohydrate transmembrane transporter activity + + + + + Enables the transfer of carbohydrate from one side of a membrane to the other. + GOC:jl + GOC:mtg_transport + ISBN:0815340729 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. + Reactome:R-HSA-189242 + Reactome:R-HSA-5638222 + hexose transmembrane transporter activity + + + + + Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. + GOC:ai + GOC:mtg_transport + ISBN:0815340729 + + + + + Reactome:R-HSA-189242 + SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region + + + + + Reactome:R-HSA-5638222 + Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + polysaccharide transmembrane transporter activity + + + + + Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GOC:ai + GOC:mtg_transport + ISBN:0815340729 + @@ -35784,8 +52385,17 @@ + The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. actin cytoskeleton + + + + The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. + GOC:jl + ISBN:0395825172 + ISBN:0815316194 + @@ -35793,8 +52403,16 @@ + The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. microtubule cytoskeleton + + + + The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. + GOC:jl + ISBN:0395825172 + @@ -35802,8 +52420,15 @@ + The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. gas transport + + + + The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -35828,8 +52453,119 @@ + The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. oxygen transport + + + + The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + bicarbonate transport + + + + + The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:krc + + + + + + + + + + + + + + + + + + + + + + + + + + The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + monocarboxylic acid transport + + + + + The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:krc + + + + + + + + + + + + + + + + + + + + + + + + + + + + The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + bile acid and bile salt transport + + + + + The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:dph + GOC:krc + PMID:12663868 + PMID:14699511 + @@ -35860,8 +52596,15 @@ + The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. polysaccharide transport + + + + The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. + GOC:ai + @@ -35886,8 +52629,15 @@ + The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. peptide transport + + + + The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -35912,8 +52662,49 @@ + The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. amine transport + + + + The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + organic acid transport + + + + + The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + ISBN:0198506732 + @@ -35938,8 +52729,15 @@ + The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. organic hydroxy compound transport + + + + The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. + GOC:ai + @@ -35966,8 +52764,15 @@ + The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. protein-DNA complex transport + + + + The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -35992,8 +52797,16 @@ + The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. norepinephrine transport + + + + The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. + GOC:ai + ISBN:0198506732 + @@ -36018,8 +52831,70 @@ + The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. nucleobase-containing compound transport + + + + The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. + nucleobase-containing compound transmembrane transporter activity + + + + + Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. + GOC:ai + + + + + + + + + The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. + energy derivation by oxidation of organic compounds + + + + + The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. + GOC:mah + @@ -36028,8 +52903,53 @@ + A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. + Wikipedia:Biological_membrane + Wikipedia:Transmembrane_protein membrane + + + + A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. + GOC:dos + GOC:mah + ISBN:0815316194 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + Wikipedia:Lipid_catabolism + lipid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. + GOC:go_curators + @@ -36054,8 +52974,17 @@ + A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. cellular component organization + + + + A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. + GOC:ai + GOC:jl + GOC:mah + @@ -36081,8 +53010,15 @@ + The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. cell growth + + + + The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. + GOC:ai + @@ -36107,8 +53043,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. vesicle organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. + GOC:mah + @@ -36133,8 +53076,118 @@ + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. carbohydrate biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + carbohydrate catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. + organic acid biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. + organic acid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. + ISBN:0198506732 + @@ -36159,8 +53212,17 @@ + Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. regulation of membrane potential in photoreceptor cell + + + + Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. + GOC:dph + GOC:hb + GOC:tb + @@ -36185,8 +53247,15 @@ + The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. RNA metabolic process + + + + The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. + ISBN:0198506732 + @@ -36212,8 +53281,17 @@ + A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. vesicle-mediated transport + + + + A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. + GOC:ai + GOC:mah + ISBN:08789310662000 + @@ -36239,8 +53317,15 @@ + Any process that modulates the frequency, rate or extent of striated muscle development. regulation of striated muscle tissue development + + + + Any process that modulates the frequency, rate or extent of striated muscle development. + GOC:go_curators + @@ -36265,8 +53350,15 @@ + The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. female meiosis chromosome segregation + + + + The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. + GOC:ai + @@ -36301,8 +53393,16 @@ + Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster. oocyte microtubule cytoskeleton organization + + + + Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster. + GOC:mtg_sensu + PMID:11231123 + @@ -36311,8 +53411,15 @@ + The process in which the anatomical structures of embryonic epithelia are generated and organized. morphogenesis of embryonic epithelium + + + + The process in which the anatomical structures of embryonic epithelia are generated and organized. + GOC:jl + @@ -36326,8 +53433,20 @@ + The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. + Wikipedia:Cell_migration cell migration + + + + The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. + GOC:cjm + GOC:dph + GOC:ems + GOC:pf + Wikipedia:Cell_migration + @@ -36353,8 +53472,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. negative regulation of angiogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. + GOC:go_curators + @@ -36405,8 +53531,134 @@ + The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. + Wikipedia:Sarcoplasm sarcoplasm + + + + The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. + ISBN:0198547684 + + + + + + + + + Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. + EC:3.-.-.- + Reactome:R-HSA-1236938 + Reactome:R-HSA-2029475 + Reactome:R-HSA-5694583 + Reactome:R-HSA-5695964 + Reactome:R-HSA-6786190 + Reactome:R-HSA-6788295 + Reactome:R-HSA-8938314 + Reactome:R-HSA-8952137 + hydrolase activity + + + + + Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. + ISBN:0198506732 + + + + + Reactome:R-HSA-1236938 + Partial proteolysis of antigen in phagolysosomes + + + + + Reactome:R-HSA-2029475 + Production of AA by iPLA2 upon FCGR activation + + + + + Reactome:R-HSA-5694583 + ABHD4 hydrolyses NAPE + + + + + Reactome:R-HSA-5695964 + ABHD14B hydrolyses PNPB + + + + + Reactome:R-HSA-6786190 + CMBL hydrolyses OM to OLMS + + + + + Reactome:R-HSA-6788295 + HDHD1:Mg2+ dephosphorylates PURIDP + + + + + Reactome:R-HSA-8938314 + ENPPs hydrolyse CoA-SH to PPANT, PAP + + + + + Reactome:R-HSA-8952137 + Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate + + + + + + + + + Catalysis of the hydrolysis of any ester bond. + EC:3.1.-.- + Reactome:R-HSA-162729 + Reactome:R-HSA-9023617 + Reactome:R-HSA-9023619 + Reactome:R-HSA-9749609 + hydrolase activity, acting on ester bonds + + + + + Catalysis of the hydrolysis of any ester bond. + GOC:jl + + + + + Reactome:R-HSA-162729 + uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid + + + + + Reactome:R-HSA-9023617 + Butyrylcholinesterase hydrolyzes acyl Ghrelin + + + + + Reactome:R-HSA-9023619 + Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin + + + + + Reactome:R-HSA-9749609 + BCHE hydrolyzes ASA- + @@ -36432,8 +53684,16 @@ + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. nucleologenesis + + + + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. + GOC:jl + ISBN:0198506732 + @@ -36458,8 +53718,16 @@ + The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. stem cell division + + + + The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. + GOC:jid + ISBN:0582227089 + @@ -36486,8 +53754,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. negative regulation of translation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. + GOC:isa_complete + @@ -36513,8 +53788,15 @@ + Any process that modulates the frequency, rate or extent of exocytosis. regulation of exocytosis + + + + Any process that modulates the frequency, rate or extent of exocytosis. + GOC:go_curators + @@ -36539,8 +53821,43 @@ + The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + UM-BBD_pathwayID:phe + Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. phenol-containing compound metabolic process + + + + The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + The specific behavior of an organism that is associated with reproduction. + reproductive behavior + + + + + The specific behavior of an organism that is associated with reproduction. + GOC:jl + GOC:pr + @@ -36565,8 +53882,48 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. regulation of lipid metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. + regulation of steroid metabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators + @@ -36591,8 +53948,15 @@ + Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. regulation of nucleobase-containing compound metabolic process + + + + Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:go_curators + @@ -36617,8 +53981,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. regulation of metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. + GOC:go_curators + @@ -36644,8 +54015,16 @@ + The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. transmission of nerve impulse + + + + The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. + GOC:curators + ISBN:0815316194 + @@ -36676,8 +54055,17 @@ + An action potential that occurs in a neuron. neuronal action potential + + + + An action potential that occurs in a neuron. + GOC:dph + GOC:isa_complete + GOC:tb + @@ -36685,8 +54073,149 @@ + The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. + Wikipedia:Nociception sensory perception of pain + + + + The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. + GOC:curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + hexose metabolic process + + + + + The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + hexose biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + hexose catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + MetaCyc:PHENOLDEG-PWY + phenol-containing compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + ISBN:0198506732 + @@ -36711,8 +54240,50 @@ + The chemical reactions and pathways involving a protein. Includes protein modification. + Wikipedia:Protein_metabolism + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. protein metabolic process + + + + The chemical reactions and pathways involving a protein. Includes protein modification. + GOC:ma + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. + catechol-containing compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. + GOC:go_curators + @@ -36750,8 +54321,50 @@ + Any process involved in the maintenance of an internal steady state at the level of the cell. cellular homeostasis + + + + Any process involved in the maintenance of an internal steady state at the level of the cell. + GOC:isa_complete + GOC:jl + ISBN:0395825172 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). + carboxylic acid metabolic process + + + + + The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). + ISBN:0198506732 + @@ -36759,8 +54372,15 @@ + The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. outer membrane + + + + The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. + GOC:go_curators + @@ -36768,8 +54388,20 @@ + The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + Wikipedia:Antigen_presentation antigen processing and presentation + + + + The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. + GOC:add + GO_REF:0000022 + ISBN:0781735149 + PMID:15771591 + PMID:15928678 + @@ -36777,8 +54409,17 @@ + A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). + Wikipedia:Sexual_reproduction + Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. sexual reproduction + + + + A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). + Wikipedia:Sexual_reproduction + @@ -36809,8 +54450,19 @@ + The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. prechordal plate formation + + + + The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -36841,8 +54493,19 @@ + The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. spinal cord development + + + + The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -36878,8 +54541,20 @@ + The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. ventral spinal cord interneuron differentiation + + + + The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:11262869 + @@ -36910,8 +54585,20 @@ + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. cell differentiation in spinal cord + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:11262869 + @@ -36942,8 +54629,19 @@ + The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. ventral spinal cord development + + + + The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -36975,8 +54673,20 @@ + The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. spinal cord motor neuron differentiation + + + + The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:11262869 + @@ -36990,8 +54700,19 @@ + The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. neural tube patterning + + + + The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -37034,8 +54755,19 @@ + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. cell differentiation in hindbrain + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -37078,8 +54810,19 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. cell proliferation in hindbrain + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -37122,8 +54865,19 @@ + The orderly movement of a cell that will reside in the hindbrain. cell migration in hindbrain + + + + The orderly movement of a cell that will reside in the hindbrain. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -37148,8 +54902,20 @@ + The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. cranial nerve development + + + + The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37180,8 +54946,20 @@ + The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. rhombomere development + + + + The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37219,8 +54997,21 @@ + The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. midbrain-hindbrain boundary initiation + + + + The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. + GOC:cls + GOC:dgh + GOC:dph + GOC:isa_complete + GOC:jid + GO_REF:0000021 + PMID:15541513 + @@ -37251,8 +55042,20 @@ + The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. pons development + + + + The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37283,8 +55086,20 @@ + The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. medulla oblongata development + + + + The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37315,8 +55130,20 @@ + The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. central nervous system morphogenesis + + + + The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0582227089 + @@ -37347,8 +55174,20 @@ + The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. midbrain-hindbrain boundary morphogenesis + + + + The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:15541513 + @@ -37379,8 +55218,20 @@ + The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. central nervous system formation + + + + The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0582227089 + @@ -37405,8 +55256,20 @@ + The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. trigeminal nerve development + + + + The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37437,8 +55300,20 @@ + The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. hindbrain morphogenesis + + + + The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37469,8 +55344,20 @@ + The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. hindbrain formation + + + + The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37507,8 +55394,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. hindbrain maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37545,8 +55444,20 @@ + The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. medulla oblongata morphogenesis + + + + The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37583,8 +55494,20 @@ + The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. medulla oblongata formation + + + + The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37621,8 +55544,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. medulla oblongata maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37659,8 +55594,20 @@ + The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. pons morphogenesis + + + + The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37697,8 +55644,20 @@ + The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. pons formation + + + + The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37735,8 +55694,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. pons maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37767,8 +55738,20 @@ + The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. rhombomere morphogenesis + + + + The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37799,8 +55782,20 @@ + The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. rhombomere formation + + + + The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37831,8 +55826,20 @@ + The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. cranial nerve morphogenesis + + + + The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37863,8 +55870,20 @@ + The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. cranial nerve formation + + + + The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37895,8 +55914,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. cranial nerve maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37927,8 +55958,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. central nervous system maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0582227089 + @@ -37959,8 +56002,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. trigeminal nerve maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -37991,8 +56046,20 @@ + The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. trigeminal nerve morphogenesis + + + + The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38023,8 +56090,20 @@ + The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. trigeminal nerve formation + + + + The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38055,8 +56134,19 @@ + The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. rhombomere boundary formation + + + + The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38087,8 +56177,19 @@ + The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. nerve development + + + + The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38119,8 +56220,19 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state. nerve maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38128,8 +56240,19 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. developmental maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38160,8 +56283,20 @@ + The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. locus ceruleus development + + + + The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38198,8 +56333,20 @@ + The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. locus ceruleus morphogenesis + + + + The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38236,8 +56383,20 @@ + The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. locus ceruleus formation + + + + The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38274,8 +56433,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. locus ceruleus maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38306,8 +56477,20 @@ + The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. superior olivary nucleus development + + + + The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38344,8 +56527,20 @@ + The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. superior olivary nucleus morphogenesis + + + + The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38382,8 +56577,20 @@ + The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. superior olivary nucleus formation + + + + The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38420,8 +56627,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. superior olivary nucleus maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0838580343 + @@ -38452,8 +56671,20 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. midbrain-hindbrain boundary maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:15541513 + @@ -38484,8 +56715,20 @@ + The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure. salivary nucleus development + + + + The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure. + GOC:cls + GOC:curators + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38510,8 +56753,20 @@ + The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. superior salivary nucleus development + + + + The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. + GOC:cls + GOC:curators + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38542,8 +56797,19 @@ + The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. glial cell development + + + + The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38557,8 +56823,20 @@ + The process in which the neural tube is divided into specific regions along the rostrocaudal axis. rostrocaudal neural tube patterning + + + + The process in which the neural tube is divided into specific regions along the rostrocaudal axis. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:11262869 + @@ -38589,8 +56867,20 @@ + The process whose specific outcome is the formation of the hindbrain-spinal cord boundary. hindbrain-spinal cord boundary formation + + + + The process whose specific outcome is the formation of the hindbrain-spinal cord boundary. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:11262869 + @@ -38628,8 +56918,19 @@ + The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. neural tube development + + + + The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38660,8 +56961,19 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. central nervous system neuron differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38692,8 +57004,19 @@ + The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. central nervous system neuron development + + + + The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38724,8 +57047,22 @@ + The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. neural plate formation + + + + The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + ISBN:0878932437 + ISBN:0878932585 + PMID:15806586 + @@ -38734,8 +57071,19 @@ + The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate. neural plate anterior/posterior regionalization + + + + The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38749,8 +57097,21 @@ + Generation of cells within the nervous system. + Wikipedia:Neurogenesis neurogenesis + + + + Generation of cells within the nervous system. + GOC:cls + GOC:curators + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38775,8 +57136,19 @@ + The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. central nervous system vasculogenesis + + + + The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38807,8 +57179,20 @@ + The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. rhombomere cell migration + + + + The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. + GOC:cls + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + PMID:15629700 + @@ -38839,8 +57223,20 @@ + The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. metencephalon development + + + + The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. + GOC:cls + GOC:curators + GOC:dgh + GOC:dph + GOC:jid + GO_REF:0000021 + @@ -38865,8 +57261,16 @@ + The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. cell cycle process + + + + The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. + GOC:isa_complete + GOC:mtg_cell_cycle + @@ -38874,8 +57278,16 @@ + The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. membrane docking + + + + The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. + GOC:isa_complete + PMID:27875684 + @@ -38900,8 +57312,15 @@ + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. regulation of cell-cell adhesion + + + + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. + GOC:isa_complete + @@ -38927,8 +57346,15 @@ + Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. negative regulation of cell-cell adhesion + + + + Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. + GOC:isa_complete + @@ -38954,8 +57380,15 @@ + Any process that activates or increases the rate or extent of cell adhesion to another cell. positive regulation of cell-cell adhesion + + + + Any process that activates or increases the rate or extent of cell adhesion to another cell. + GOC:isa_complete + @@ -38981,8 +57414,16 @@ + A cellular process that results in the breakdown of a cellular component. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular component disassembly + + + + A cellular process that results in the breakdown of a cellular component. + GOC:isa_complete + @@ -38999,8 +57440,15 @@ + A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. cellular process involved in reproduction in multicellular organism + + + + A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. + GOC:isa_complete + @@ -39008,8 +57456,17 @@ + A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + Wikipedia:Reproduction reproductive process + + + + A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. + GOC:dph + GOC:isa_complete + @@ -39034,8 +57491,17 @@ + A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. digestive system process + + + + A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:isa_complete + GOC:jid + GOC:mtg_cardio + @@ -39060,8 +57526,15 @@ + Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. regulation of anatomical structure morphogenesis + + + + Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. + GOC:mah + @@ -39086,8 +57559,15 @@ + Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. regulation of cell morphogenesis + + + + Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. + GOC:isa_complete + @@ -39118,8 +57598,15 @@ + The aggregation, arrangement and bonding together of a cellular component. cellular component assembly + + + + The aggregation, arrangement and bonding together of a cellular component. + GOC:isa_complete + @@ -39150,8 +57637,15 @@ + The process in which the anatomical structures of a gland are generated and organized. gland morphogenesis + + + + The process in which the anatomical structures of a gland are generated and organized. + GOC:isa_complete + @@ -39159,8 +57653,16 @@ + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. ribonucleoprotein complex biogenesis + + + + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. + GOC:isa_complete + GOC:mah + @@ -39186,8 +57688,15 @@ + A process that results in the breakdown of the extracellular matrix. extracellular matrix disassembly + + + + A process that results in the breakdown of the extracellular matrix. + GOC:jid + @@ -39219,8 +57728,175 @@ + The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. protein-RNA complex assembly + + + + The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. + Reactome:R-HSA-1236947 + Reactome:R-HSA-429036 + Reactome:R-HSA-434650 + Reactome:R-HSA-5638209 + Reactome:R-HSA-5671707 + Reactome:R-HSA-6784434 + Reactome:R-HSA-6784436 + transmembrane transporter activity + + + + + Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. + GOC:jid + GOC:mtg_transport + ISBN:0815340729 + + + + + Reactome:R-HSA-1236947 + Egress of internalized antigen to the cytosol via sec61 + + + + + Reactome:R-HSA-429036 + SLC2A9 transports Fru, Glc, urate + + + + + Reactome:R-HSA-434650 + MATEs mediate extrusion of xenobiotics + + + + + Reactome:R-HSA-5638209 + Defective SLC2A9 does not transport Fru, Glc, urate + + + + + Reactome:R-HSA-5671707 + Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA + + + + + Reactome:R-HSA-6784434 + An unknown carrier transports cytosolic glyoxylate to the peroxisome + + + + + Reactome:R-HSA-6784436 + An unknown carrier transports mitochondrial glyoxylate to the cytosol + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a macromolecule from one side of a membrane to the other. + macromolecule transmembrane transporter activity + + + + + Enables the transfer of a macromolecule from one side of a membrane to the other. + GOC:mtg_transport + ISBN:0815340729 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of transmembrane transporter activity. + regulation of transmembrane transporter activity + + + + + Any process that modulates the frequency, rate or extent of transmembrane transporter activity. + GOC:dph + GOC:mtg_cardio + GOC:mtg_transport + @@ -39245,8 +57921,15 @@ + Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. signal transduction involved in regulation of gene expression + + + + Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. + GOC:mtg_signal + @@ -39271,8 +57954,15 @@ + Any process that modulates the frequency, rate or extent of a signaling process. regulation of signaling + + + + Any process that modulates the frequency, rate or extent of a signaling process. + GOC:mtg_signal + @@ -39280,8 +57970,18 @@ + The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. + Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. signaling + + + + The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. + GOC:mtg_signal + GOC:mtg_signaling_feb11 + GOC:signaling + @@ -39307,8 +58007,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. positive regulation of signaling + + + + Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. + GOC:mtg_signal + @@ -39334,8 +58041,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. negative regulation of signaling + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. + GOC:mtg_signal + @@ -39360,8 +58074,15 @@ + The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. signal release + + + + The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. + GOC:mtg_signal + @@ -39369,8 +58090,15 @@ + The specification and formation of anisotropic intracellular organization or cell growth patterns. establishment of cell polarity + + + + The specification and formation of anisotropic intracellular organization or cell growth patterns. + GOC:mah + @@ -39395,8 +58123,16 @@ + The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. + Wikipedia:Myofibril myofibril + + + + The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. + ISBN:0815316194 + @@ -39410,8 +58146,16 @@ + The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + Wikipedia:Sarcomere sarcomere + + + + The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + ISBN:0815316194 + @@ -39436,8 +58180,15 @@ + Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. actin filament-based process + + + + Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. + GOC:mah + @@ -39462,8 +58213,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. cell projection organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. + GOC:jl + GOC:mah + PMID:16318917 + @@ -39489,8 +58249,17 @@ + Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. cell projection assembly + + + + Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. + GOC:jl + GOC:mah + PMID:18391171 + @@ -39516,8 +58285,16 @@ + Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. microvillus assembly + + + + Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. + GOC:mah + ISBN:0815316194 + @@ -39543,8 +58320,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. actin cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. + GOC:dph + GOC:jl + GOC:mah + @@ -39552,8 +58338,16 @@ + Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. actin filament-based movement + + + + Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. + GOC:BHF + GOC:mah + @@ -39578,8 +58372,15 @@ + Movement of a vesicle along an actin filament, mediated by motor proteins. vesicle transport along actin filament + + + + Movement of a vesicle along an actin filament, mediated by motor proteins. + GOC:mah + @@ -39613,8 +58414,21 @@ + A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. + Wikipedia:Cell_junction cell junction + + + + A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. + GOC:aruk + GOC:bc + GOC:mah + ISBN:0198506732 + PMID:26820516 + PMID:28096264 + @@ -39640,8 +58454,62 @@ + The regulated release of a peptide hormone from a cell. peptide hormone secretion + + + + The regulated release of a peptide hormone from a cell. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. + insulin secretion + + + + + The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. + GOC:mah + ISBN:0198506732 + @@ -39678,8 +58546,17 @@ + The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. + Wikipedia:Haematopoiesis hemopoiesis + + + + The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. + GOC:dgh + ISBN:0198506732 + @@ -39705,8 +58582,17 @@ + The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. lymphocyte differentiation + + + + The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + CL:0000542 + GOC:go_curators + @@ -39737,8 +58623,16 @@ + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. myeloid cell differentiation + + + + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. + GOC:add + ISBN:0781735149 + @@ -39764,8 +58658,15 @@ + Any process that modulates the frequency, rate or extent of endocytosis. regulation of endocytosis + + + + Any process that modulates the frequency, rate or extent of endocytosis. + GOC:go_curators + @@ -39779,8 +58680,18 @@ + Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. + NIF_Subcellular:sao885490876 + Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. transport vesicle + + + + Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. + GOC:mah + PMID:22160157 + @@ -39820,8 +58731,17 @@ + A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. + Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. secretory granule + + + + A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. + GOC:mah + ISBN:0198506732 + @@ -39846,8 +58766,16 @@ + The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. + Wikipedia:Cellular_differentiation cell differentiation + + + + The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. + ISBN:0198506732 + @@ -39872,8 +58800,50 @@ + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. regulation of cell adhesion + + + + Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + Wikipedia:Protein_catabolism + This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. + protein catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + GOC:mah + @@ -39904,8 +58874,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuron. neuron differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuron. + GOC:mah + @@ -39931,8 +58908,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. extracellular matrix organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. + GOC:mah + @@ -39984,8 +58968,16 @@ + Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. collagen fibril organization + + + + Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. + GOC:mah + ISBN:0815316194 + @@ -40010,8 +59002,15 @@ + The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. glycosaminoglycan metabolic process + + + + The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. + ISBN:0192800981 + @@ -40036,8 +59035,16 @@ + The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. hyaluronan metabolic process + + + + The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. + GOC:mah + ISBN:0198506732 + @@ -40062,8 +59069,51 @@ + The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. hyaluronan biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. + GOC:mah + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. + MetaCyc:PWY-7645 + hyaluronan catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. + GOC:mah + ISBN:0198506732 + @@ -40089,8 +59139,18 @@ + The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. + Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. T cell differentiation + + + + The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. + GOC:jid + GOC:mah + GO_REF:0000022 + @@ -40121,8 +59181,16 @@ + The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. + Wikipedia:Erythropoiesis erythrocyte differentiation + + + + The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. + GOC:mah + @@ -40147,8 +59215,15 @@ + The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. megakaryocyte differentiation + + + + The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. + GOC:mah + @@ -40174,8 +59249,15 @@ + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. monocyte differentiation + + + + The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. + GOC:mah + @@ -40201,8 +59283,16 @@ + The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. macrophage differentiation + + + + The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. + GOC:add + ISBN:0781735149 + @@ -40235,8 +59325,15 @@ + Formation of myofibrils, the repeating units of striated muscle. myofibril assembly + + + + Formation of myofibrils, the repeating units of striated muscle. + GOC:mah + @@ -40244,8 +59341,16 @@ + The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. chromosome condensation + + + + The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. + GOC:mah + ISBN:0815316194 + @@ -40253,8 +59358,16 @@ + Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. apoptotic nuclear changes + + + + Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. + GOC:mah + GOC:mtg_apoptosis + @@ -40268,8 +59381,16 @@ + The compaction of chromatin during apoptosis. + Wikipedia:Pyknosis apoptotic chromosome condensation + + + + The compaction of chromatin during apoptosis. + GOC:mah + @@ -40294,8 +59415,19 @@ + The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. nuclear fragmentation involved in apoptotic nuclear change + + + + The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. + GOC:dph + GOC:mah + GOC:mtg_apoptosis + GOC:tb + ISBN:0721639976 + @@ -40320,8 +59452,15 @@ + Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. regulation of ossification + + + + Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators + @@ -40347,8 +59486,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. negative regulation of ossification + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators + @@ -40375,8 +59521,15 @@ + Any process that activates or increases the frequency, rate, extent or direction of cell growth. positive regulation of cell growth + + + + Any process that activates or increases the frequency, rate, extent or direction of cell growth. + GOC:go_curators + @@ -40403,8 +59556,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. negative regulation of cell growth + + + + Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. + GOC:go_curators + @@ -40424,8 +59584,16 @@ + A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. + The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. external encapsulating structure + + + + A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. + GOC:go_curators + @@ -40450,8 +59618,18 @@ + The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. osteoclast differentiation + + + + The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. + CL:0000092 + GOC:add + ISBN:0781735149 + PMID:12161749 + @@ -40477,8 +59655,15 @@ + The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract. respiratory tube development + + + + The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract. + GOC:jid + @@ -40515,8 +59700,16 @@ + The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. lung development + + + + The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. + GOC:jid + UBERON:0002048 + @@ -40567,8 +59760,15 @@ + Any process that modulates the frequency, rate or extent of cell migration. regulation of cell migration + + + + Any process that modulates the frequency, rate or extent of cell migration. + GOC:go_curators + @@ -40594,8 +59794,15 @@ + Any process that activates or increases the frequency, rate or extent of cell migration. positive regulation of cell migration + + + + Any process that activates or increases the frequency, rate or extent of cell migration. + GOC:go_curators + @@ -40621,8 +59828,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. negative regulation of cell migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. + GOC:go_curators + @@ -40648,8 +59862,50 @@ + The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. membrane disassembly + + + + The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. + GOC:mah + + + + + + + + + + The expulsion of feces from the rectum. + Wikipedia:Defecation + defecation + + + + + The expulsion of feces from the rectum. + GOC:mah + + + + + + + + + A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. + Wikipedia:Peristalsis + peristalsis + + + + + A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. + ISBN:0198506732 + @@ -40675,8 +59931,16 @@ + The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. nuclear migration along microtubule + + + + The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. + GOC:mah + GOC:sgd_curators + @@ -40701,8 +59965,82 @@ + The contractile fiber of smooth muscle cells. smooth muscle contractile fiber + + + + The contractile fiber of smooth muscle cells. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. + bile acid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. + collagen catabolic process + + + + + The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. + GOC:mah + ISBN:0815316194 + @@ -40722,8 +60060,16 @@ + The movement of a leukocyte in response to an external stimulus. leukocyte chemotaxis + + + + The movement of a leukocyte in response to an external stimulus. + GOC:add + GOC:jl + @@ -40755,8 +60101,15 @@ + The lipid bilayer surrounding a transport vesicle. transport vesicle membrane + + + + The lipid bilayer surrounding a transport vesicle. + GOC:mah + @@ -40781,8 +60134,15 @@ + The lipid bilayer surrounding a cytoplasmic vesicle. cytoplasmic vesicle membrane + + + + The lipid bilayer surrounding a cytoplasmic vesicle. + GOC:mah + @@ -40814,8 +60174,15 @@ + The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. Golgi-associated vesicle membrane + + + + The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. + GOC:mah + @@ -40847,8 +60214,15 @@ + The lipid bilayer surrounding a secretory granule. secretory granule membrane + + + + The lipid bilayer surrounding a secretory granule. + GOC:mah + @@ -40873,8 +60247,15 @@ + The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. cytoskeleton-dependent intracellular transport + + + + The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. + GOC:mah + @@ -40917,8 +60298,16 @@ + Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber. oocyte localization involved in germarium-derived egg chamber formation + + + + Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber. + GOC:mtg_sensu + PMID:10449356 + @@ -40943,8 +60332,16 @@ + The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. granulocyte differentiation + + + + The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. + GOC:ecd + http://life.nthu.edu.tw/~g864204/dict-search1.htm + @@ -40969,8 +60366,15 @@ + Any process that modulates the frequency, rate or extent of granulocyte differentiation. regulation of granulocyte differentiation + + + + Any process that modulates the frequency, rate or extent of granulocyte differentiation. + GOC:mah + @@ -40996,8 +60400,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation. negative regulation of granulocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation. + GOC:mah + @@ -41023,8 +60434,15 @@ + Any process that activates or increases the frequency, rate or extent of granulocyte differentiation. positive regulation of granulocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of granulocyte differentiation. + GOC:mah + @@ -41055,8 +60473,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. epithelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. + GOC:ecd + PMID:11839751 + @@ -41082,8 +60508,15 @@ + Any process that modulates the frequency, rate or extent of epithelial cell differentiation. regulation of epithelial cell differentiation + + + + Any process that modulates the frequency, rate or extent of epithelial cell differentiation. + GOC:mah + @@ -41109,8 +60542,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. negative regulation of epithelial cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. + GOC:mah + @@ -41136,8 +60576,15 @@ + Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. positive regulation of epithelial cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. + GOC:mah + @@ -41162,8 +60609,15 @@ + Any process that modulates the frequency or rate of myeloid dendritic cell activation. regulation of myeloid dendritic cell activation + + + + Any process that modulates the frequency or rate of myeloid dendritic cell activation. + GOC:mah + @@ -41189,8 +60643,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation. negative regulation of myeloid dendritic cell activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation. + GOC:mah + @@ -41216,8 +60677,15 @@ + Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation. positive regulation of myeloid dendritic cell activation + + + + Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation. + GOC:mah + @@ -41248,8 +60716,16 @@ + The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). midbrain development + + + + The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). + PMID:4975589 + PMID:4992177 + @@ -41280,8 +60756,16 @@ + The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). hindbrain development + + + + The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). + PMID:4975589 + PMID:4992177 + @@ -41306,8 +60790,15 @@ + The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. notochord development + + + + The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. + GOC:dgh + @@ -41344,8 +60835,15 @@ + The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. midbrain-hindbrain boundary development + + + + The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. + GOC:dgh + @@ -41365,8 +60863,15 @@ + Any collagen trimer that passes through a lipid bilayer membrane. transmembrane collagen trimer + + + + Any collagen trimer that passes through a lipid bilayer membrane. + ISBN:0721639976 + @@ -41375,8 +60880,15 @@ + Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. establishment or maintenance of microtubule cytoskeleton polarity + + + + Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. + GOC:mah + @@ -41385,8 +60897,15 @@ + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures. establishment or maintenance of cytoskeleton polarity + + + + Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures. + GOC:mah + @@ -41400,8 +60919,20 @@ + A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. + Note that we deem cilia and microtubule-based flagella to be equivalent. intraciliary transport particle + + + + A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. + GOC:cilia + GOC:kmv + PMID:14570576 + PMID:22118932 + PMID:23945166 + @@ -41411,8 +60942,152 @@ + A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. + NIF_Subcellular:nlx_subcell_20090513 + Wikipedia:Extracellular_matrix extracellular matrix + + + + A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. + GOC:BHF + GOC:mah + GOC:rph + NIF_Subcellular:nlx_subcell_20090513 + PMID:21123617 + PMID:28089324 + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones. + Wikipedia:Pancreas + pancreas development + + + + + The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones. + GOC:cvs + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. + exocrine pancreas development + + + + + The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. + GOC:cvs + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. + endocrine pancreas development + + + + + The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. + GOC:cvs + @@ -41433,8 +61108,15 @@ + The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. nuclear migration along microfilament + + + + The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. + GOC:mah + @@ -41459,8 +61141,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. + Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. actomyosin structure organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. + GOC:dph + GOC:jl + GOC:mah + @@ -41468,8 +61160,17 @@ + Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. + NIF_Subcellular:sao772007592 dense core granule + + + + Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. + NIF_Subcellular:sao772007592 + PMID:14690495 + @@ -41478,8 +61179,16 @@ + The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. embryonic camera-type eye development + + + + The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. + GOC:mah + GOC:mtg_sensu + @@ -41504,8 +61213,17 @@ + A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. + NIF_Subcellular:sao830981606 organelle membrane + + + + A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. + GOC:dos + GOC:mah + @@ -41513,8 +61231,15 @@ + Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. microtubule polymerization or depolymerization + + + + Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. + GOC:mah + @@ -41539,8 +61264,15 @@ + Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. regulation of microtubule polymerization or depolymerization + + + + Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. + GOC:mah + @@ -41566,8 +61298,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. negative regulation of microtubule polymerization or depolymerization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. + GOC:mah + @@ -41593,8 +61332,15 @@ + Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. positive regulation of microtubule polymerization or depolymerization + + + + Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. + GOC:mah + @@ -41620,8 +61366,15 @@ + Any process that modulates the frequency, rate or extent of microtubule polymerization. regulation of microtubule polymerization + + + + Any process that modulates the frequency, rate or extent of microtubule polymerization. + GOC:mah + @@ -41647,8 +61400,15 @@ + Any process that modulates the frequency, rate or extent of microtubule depolymerization. regulation of microtubule depolymerization + + + + Any process that modulates the frequency, rate or extent of microtubule depolymerization. + GOC:mah + @@ -41675,8 +61435,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. negative regulation of microtubule polymerization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. + GOC:mah + @@ -41703,8 +61470,15 @@ + Any process that activates or increases the frequency, rate or extent of microtubule polymerization. positive regulation of microtubule polymerization + + + + Any process that activates or increases the frequency, rate or extent of microtubule polymerization. + GOC:mah + @@ -41731,8 +61505,15 @@ + Any process that activates or increases the frequency, rate or extent of microtubule depolymerization. positive regulation of microtubule depolymerization + + + + Any process that activates or increases the frequency, rate or extent of microtubule depolymerization. + GOC:mah + @@ -41758,8 +61539,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. cytoplasmic microtubule organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. + GOC:mah + @@ -41810,8 +61598,18 @@ + A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). developmental induction + + + + A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). + GOC:cjm + GOC:dph + GOC:mah + PMID:24503535 + @@ -41819,8 +61617,16 @@ + A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. + Wikipedia:Pseudopod pseudopodium + + + + A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. + ISBN:0198506732 + @@ -41845,8 +61651,15 @@ + The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). neuron projection development + + + + The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). + GOC:mah + @@ -41860,8 +61673,15 @@ + The area of a motile cell closest to the direction of movement. cell leading edge + + + + The area of a motile cell closest to the direction of movement. + GOC:pg + @@ -41892,8 +61712,16 @@ + The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. cell projection membrane + + + + The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. + GOC:krc + GOC:mah + @@ -41913,8 +61741,15 @@ + The portion of the plasma membrane surrounding the leading edge of a motile cell. leading edge membrane + + + + The portion of the plasma membrane surrounding the leading edge of a motile cell. + GOC:mah + @@ -41939,8 +61774,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement. pseudopodium organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement. + GOC:pg + @@ -41966,8 +61808,18 @@ + The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane. pseudopodium assembly + + + + The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane. + GOC:dph + GOC:mah + GOC:pg + GOC:tb + @@ -41993,8 +61845,15 @@ + The myosin-based contraction and retraction of a pseudopodium. pseudopodium retraction + + + + The myosin-based contraction and retraction of a pseudopodium. + GOC:pg + @@ -42020,8 +61879,15 @@ + Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. regulation of pseudopodium assembly + + + + Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. + GOC:pg + @@ -42047,8 +61913,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia. negative regulation of pseudopodium assembly + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia. + GOC:pg + @@ -42074,8 +61947,15 @@ + Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. positive regulation of pseudopodium assembly + + + + Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia. + GOC:pg + @@ -42101,8 +61981,16 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of cellular metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah + @@ -42129,8 +62017,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of cellular metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah + @@ -42157,8 +62053,16 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of cellular metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. + GOC:mah + @@ -42184,8 +62088,16 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of cellular biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah + @@ -42212,8 +62124,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of cellular biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah + @@ -42240,8 +62160,123 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of cellular biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + regulation of cellular catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + negative regulation of cellular catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. + positive regulation of cellular catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:mah + @@ -42267,8 +62302,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. negative regulation of protein-containing complex assembly + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. + GOC:mah + @@ -42295,8 +62337,15 @@ + Any process that activates or increases the frequency, rate or extent of protein complex assembly. positive regulation of protein-containing complex assembly + + + + Any process that activates or increases the frequency, rate or extent of protein complex assembly. + GOC:mah + @@ -42322,8 +62371,15 @@ + Any process that modulates the frequency, rate or extent of vesicle fusion. regulation of vesicle fusion + + + + Any process that modulates the frequency, rate or extent of vesicle fusion. + GOC:mah + @@ -42350,8 +62406,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. negative regulation of vesicle fusion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. + GOC:mah + @@ -42378,8 +62441,15 @@ + Any process that activates or increases the frequency, rate or extent of vesicle fusion. positive regulation of vesicle fusion + + + + Any process that activates or increases the frequency, rate or extent of vesicle fusion. + GOC:mah + @@ -42404,8 +62474,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. regulation of cell projection organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. + GOC:mah + @@ -42431,8 +62508,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. negative regulation of cell projection organization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. + GOC:mah + @@ -42458,8 +62542,15 @@ + Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. positive regulation of cell projection organization + + + + Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. + GOC:mah + @@ -42484,8 +62575,15 @@ + Any process that modulates the frequency, rate or extent of a defense response. regulation of defense response + + + + Any process that modulates the frequency, rate or extent of a defense response. + GOC:mah + @@ -42511,8 +62609,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. negative regulation of defense response + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. + GOC:mah + @@ -42538,8 +62643,15 @@ + Any process that activates or increases the frequency, rate or extent of a defense response. positive regulation of defense response + + + + Any process that activates or increases the frequency, rate or extent of a defense response. + GOC:mah + @@ -42564,8 +62676,18 @@ + A vesicle found in the cytoplasm of a cell. + NIF_Subcellular:sao180601769 cytoplasmic vesicle + + + + A vesicle found in the cytoplasm of a cell. + GOC:ai + GOC:mah + GOC:vesicles + @@ -42590,8 +62712,15 @@ + A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. protein-containing complex localization + + + + A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. + GOC:mah + @@ -42616,8 +62745,20 @@ + A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. motile cilium + + + + A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. + GOC:cilia + GOC:dgh + GOC:kmv + PMID:17009929 + PMID:20144998 + PMID:22118931 + @@ -42652,8 +62793,18 @@ + The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. + NIF_Subcellular:sao1124888485 + Wikipedia:Neuromuscular_junction + In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. neuromuscular junction + + + + The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. + GOC:nln + @@ -42678,8 +62829,17 @@ + Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. regulation of nervous system process + + + + Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. + GOC:dph + GOC:mah + GOC:tb + @@ -42705,8 +62865,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. negative regulation of nervous system process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. + GOC:dph + GOC:mah + GOC:tb + @@ -42732,8 +62901,17 @@ + Any process that activates or increases the frequency, rate or extent of a neurophysiological process. positive regulation of nervous system process + + + + Any process that activates or increases the frequency, rate or extent of a neurophysiological process. + GOC:dph + GOC:mah + GOC:tb + @@ -42758,8 +62936,17 @@ + Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. + NIF_Subcellular:sao1687101204 nuclear membrane + + + + Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. + GOC:mah + GOC:pz + @@ -42779,8 +62966,16 @@ + A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. organelle envelope + + + + A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. + GOC:mah + GOC:pz + @@ -42810,8 +63005,15 @@ + The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope. organelle outer membrane + + + + The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope. + GOC:mah + @@ -42820,8 +63022,16 @@ + The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. membrane-enclosed lumen + + + + The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. + GOC:add + GOC:mah + @@ -42835,8 +63045,16 @@ + The volume enclosed by the nuclear inner membrane. nuclear lumen + + + + The volume enclosed by the nuclear inner membrane. + GOC:mah + GOC:pz + @@ -42844,8 +63062,87 @@ + Any small, fluid-filled, spherical organelle enclosed by membrane. + NIF_Subcellular:sao221389602 + Wikipedia:Vesicle_(biology) vesicle + + + + Any small, fluid-filled, spherical organelle enclosed by membrane. + GOC:mah + GOC:pz + GOC:vesicles + + + + + + + + + + + + + + + + + + + + + + + + + + Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + locomotion involved in locomotory behavior + + + + + Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. + positive regulation of insulin secretion + + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. + GOC:mah + @@ -42874,8 +63171,15 @@ + Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. negative regulation of translational initiation in response to stress + + + + Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. + GOC:mah + @@ -42904,8 +63208,15 @@ + Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress. positive regulation of translational initiation in response to stress + + + + Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress. + GOC:mah + @@ -42913,8 +63224,19 @@ + A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. + Wikipedia:Bleb_(cell_biology) bleb + + + + A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. + GOC:mtg_apoptosis + PMID:12083798 + PMID:16624291 + Wikipedia:Bleb_(cell_biology) + @@ -42939,8 +63261,227 @@ + The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. bleb assembly + + + + The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. + GOC:mah + GOC:mtg_apoptosis + PMID:12083798 + PMID:16624291 + Wikipedia:Bleb_(cell_biology) + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + regulation of nuclease activity + + + + + Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + regulation of deoxyribonuclease activity + + + + + Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + negative regulation of nuclease activity + + + + + Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + positive regulation of nuclease activity + + + + + Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + negative regulation of deoxyribonuclease activity + + + + + Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + positive regulation of deoxyribonuclease activity + + + + + Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. + GOC:mah + @@ -42965,8 +63506,16 @@ + Any process that modulates the frequency, rate or extent of a response to an external stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of response to external stimulus + + + + Any process that modulates the frequency, rate or extent of a response to an external stimulus. + GOC:mah + @@ -42992,8 +63541,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of response to external stimulus + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. + GOC:mah + @@ -43019,8 +63576,16 @@ + Any process that activates, maintains or increases the rate of a response to an external stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of response to external stimulus + + + + Any process that activates, maintains or increases the rate of a response to an external stimulus. + GOC:mah + @@ -43051,8 +63616,15 @@ + The lipid bilayer surrounding a dense core granule. dense core granule membrane + + + + The lipid bilayer surrounding a dense core granule. + GOC:mah + @@ -43078,8 +63650,15 @@ + Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. regulation of actin filament bundle assembly + + + + Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. + GOC:mah + @@ -43106,8 +63685,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. negative regulation of actin filament bundle assembly + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. + GOC:mah + @@ -43135,8 +63721,15 @@ + Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. positive regulation of actin filament bundle assembly + + + + Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. + GOC:mah + @@ -43161,8 +63754,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of nucleobase-containing compound transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43188,8 +63788,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of nucleobase-containing compound transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43215,8 +63822,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of nucleobase-containing compound transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43241,8 +63855,15 @@ + Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. secretory granule localization + + + + Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. + GOC:mah + @@ -43267,8 +63888,15 @@ + Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell. dense core granule localization + + + + Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell. + GOC:mah + @@ -43293,8 +63921,15 @@ + Any process that modulates the frequency, rate or extent of the process of creating protein polymers. regulation of protein polymerization + + + + Any process that modulates the frequency, rate or extent of the process of creating protein polymers. + GOC:mah + @@ -43320,8 +63955,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. negative regulation of protein polymerization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. + GOC:mah + @@ -43347,8 +63989,15 @@ + Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. positive regulation of protein polymerization + + + + Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. + GOC:mah + @@ -43374,8 +64023,15 @@ + Any process that modulates the frequency, rate or extent of chondrocyte differentiation. regulation of chondrocyte differentiation + + + + Any process that modulates the frequency, rate or extent of chondrocyte differentiation. + GOC:mah + @@ -43402,8 +64058,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. negative regulation of chondrocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. + GOC:mah + @@ -43430,8 +64093,48 @@ + Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. positive regulation of chondrocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell. + intracellular oxygen homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell. + GOC:rph + @@ -43455,8 +64158,15 @@ + The directed movement of lipids within cells. intracellular lipid transport + + + + The directed movement of lipids within cells. + GOC:mah + @@ -43482,8 +64192,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of lipid transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43510,8 +64227,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of lipid transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43538,8 +64262,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of lipid transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -43565,8 +64296,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. regulation of intracellular lipid transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. + GOC:mah + @@ -43593,8 +64331,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells. negative regulation of intracellular lipid transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells. + GOC:mah + @@ -43621,8 +64366,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells. positive regulation of intracellular lipid transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells. + GOC:mah + @@ -43648,8 +64400,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. regulation of intracellular transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. + GOC:mah + @@ -43676,8 +64435,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. negative regulation of intracellular transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. + GOC:mah + @@ -43704,8 +64470,224 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. positive regulation of intracellular transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the activity of a transporter. + regulation of transporter activity + + + + + Any process that modulates the activity of a transporter. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the activity of a transporter. + negative regulation of transporter activity + + + + + Any process that stops or reduces the activity of a transporter. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the activity of a transporter. + positive regulation of transporter activity + + + + + Any process that activates or increases the activity of a transporter. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the activity of an ion transporter. + regulation of monoatomic ion transmembrane transporter activity + + + + + Any process that modulates the activity of an ion transporter. + GOC:mah + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the activity of an ion transporter. + negative regulation of ion transmembrane transporter activity + + + + + Any process that stops or reduces the activity of an ion transporter. + GOC:mah + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the activity of an ion transporter. + positive regulation of ion transmembrane transporter activity + + + + + Any process that activates or increases the activity of an ion transporter. + GOC:mah + GOC:tb + @@ -43730,8 +64712,15 @@ + Any process in which a lysosome is transported to, and/or maintained in, a specific location. lysosome localization + + + + Any process in which a lysosome is transported to, and/or maintained in, a specific location. + GOC:mah + @@ -43751,8 +64740,15 @@ + An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. actin filament bundle + + + + An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. + GOC:mah + @@ -43864,8 +64860,19 @@ + Any biological process, occurring at the level of a multicellular organism, pertinent to its function. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. multicellular organismal process + + + + Any biological process, occurring at the level of a multicellular organism, pertinent to its function. + GOC:curators + GOC:dph + GOC:isa_complete + GOC:tb + @@ -43873,8 +64880,15 @@ + A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. developmental process + + + + A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. + GOC:isa_complete + @@ -43925,8 +64939,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. microvillus organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. + GOC:mah + @@ -43951,8 +64972,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. regulation of microvillus organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. + GOC:mah + @@ -43978,8 +65006,15 @@ + A process that modulates the formation of a microvillus. regulation of microvillus assembly + + + + A process that modulates the formation of a microvillus. + GOC:mah + @@ -44011,8 +65046,15 @@ + The portion of the plasma membrane surrounding a neuron projection. neuron projection membrane + + + + The portion of the plasma membrane surrounding a neuron projection. + GOC:mah + @@ -44038,8 +65080,15 @@ + The directed movement of a protein from one location to another within a lipid bilayer. protein transport within lipid bilayer + + + + The directed movement of a protein from one location to another within a lipid bilayer. + GOC:mah + @@ -44064,8 +65113,83 @@ + The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. + Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. RNA biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. + GOC:mah + GOC:txnOH + + + + + + + + + + + + + + + + + + + + + + + + + + The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. + bile acid secretion + + + + + The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. + GOC:ecd + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). + monocarboxylic acid metabolic process + + + + + The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). + GOC:vk + @@ -44090,8 +65214,16 @@ + The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. ribosome disassembly + + + + The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. + GOC:mah + GOC:vk + @@ -44116,8 +65248,80 @@ + All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. plasma membrane bounded cell projection cytoplasm + + + + All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. + GOC:krc + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. + response to insulin + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. + GOC:mah + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. + cellular response to insulin stimulus + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. + GOC:mah + ISBN:0198506732 + @@ -44142,8 +65346,15 @@ + Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion. regulation of karyogamy + + + + Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion. + GOC:mah + @@ -44168,8 +65379,15 @@ + Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. regulation of establishment or maintenance of cell polarity + + + + Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. + GOC:mah + @@ -44194,8 +65412,15 @@ + Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. regulation of localization + + + + Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. + GOC:mah + @@ -44220,8 +65445,17 @@ + Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. regulation of protein localization + + + + Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. + GOC:dph + GOC:mah + GOC:tb + @@ -44247,8 +65481,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. regulation of polysaccharide metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. + GOC:mah + @@ -44275,8 +65516,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. regulation of polysaccharide biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. + GOC:mah + @@ -44301,8 +65549,116 @@ + Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. regulation of microtubule-based process + + + + Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + regulation of organic acid transport + + + + + Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + negative regulation of organic acid transport + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + positive regulation of organic acid transport + + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -44311,8 +65667,33 @@ + The controlled release of a substance by a cell. + Wikipedia:Secretion secretion by cell + + + + The controlled release of a substance by a cell. + GOC:mah + + + + + + + + + + The controlled release of a substance by a tissue. + secretion by tissue + + + + + The controlled release of a substance by a tissue. + GOC:mah + @@ -44337,8 +65718,15 @@ + The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. mononuclear cell proliferation + + + + The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. + GOC:add + @@ -44363,8 +65751,15 @@ + Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. regulation of mononuclear cell proliferation + + + + Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. + GOC:add + @@ -44390,8 +65785,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. negative regulation of mononuclear cell proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. + GOC:add + @@ -44417,8 +65819,15 @@ + Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. positive regulation of mononuclear cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. + GOC:add + @@ -44444,8 +65853,15 @@ + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. regulation of actin cytoskeleton organization + + + + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. + GOC:mah + @@ -44470,8 +65886,16 @@ + The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). collagen metabolic process + + + + The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). + GOC:mah + ISBN:0198506732 + @@ -44496,8 +65920,16 @@ + The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). collagen biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). + GOC:mah + ISBN:0198506732 + @@ -44522,8 +65954,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. regulation of collagen biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:mah + @@ -44549,8 +65988,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. negative regulation of collagen biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:mah + @@ -44576,8 +66022,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. positive regulation of collagen biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. + GOC:mah + @@ -44602,8 +66055,15 @@ + Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. regulation of actin filament-based process + + + + Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. + GOC:mah + @@ -44629,8 +66089,15 @@ + The disaggregation of a protein-containing macromolecular complex into its constituent components. protein-containing complex disassembly + + + + The disaggregation of a protein-containing macromolecular complex into its constituent components. + GOC:mah + @@ -44656,8 +66123,15 @@ + The disaggregation of a protein-DNA complex into its constituent components. protein-DNA complex disassembly + + + + The disaggregation of a protein-DNA complex into its constituent components. + GOC:mah + @@ -44683,8 +66157,15 @@ + The disaggregation of a protein-RNA complex into its constituent components. protein-RNA complex disassembly + + + + The disaggregation of a protein-RNA complex into its constituent components. + GOC:mah + @@ -44692,8 +66173,17 @@ + The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system. cellular anatomical entity morphogenesis + + + + The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system. + GOC:dph + GOC:mah + GOC:tb + @@ -44708,8 +66198,17 @@ + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. + A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. protein-containing complex + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. + GOC:dos + GOC:mah + @@ -44723,8 +66222,16 @@ + A macromolecular complex containing both protein and DNA molecules. + Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. protein-DNA complex + + + + A macromolecular complex containing both protein and DNA molecules. + GOC:mah + @@ -44732,8 +66239,16 @@ + A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin. Fc receptor complex + + + + A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin. + GOC:add + ISBN:0781735149 + @@ -44741,8 +66256,18 @@ + A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG. Fc-gamma receptor III complex + + + + A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG. + GOC:add + ISBN:0781735149 + PMID:11244038 + PMID:12413532 + @@ -44767,8 +66292,16 @@ + The expansion of a muscle cell population by cell division. muscle cell proliferation + + + + The expansion of a muscle cell population by cell division. + CL:0000187 + GOC:mah + @@ -44793,8 +66326,20 @@ + Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. myeloid cell apoptotic process + + + + Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. + CL:0000763 + GOC:add + GOC:mtg_apoptosis + PMID:11292031 + PMID:15330259 + PMID:17133093 + @@ -44819,8 +66364,16 @@ + Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. regulation of myeloid cell apoptotic process + + + + Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. + GOC:add + GOC:mtg_apoptosis + @@ -44846,8 +66399,16 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. negative regulation of myeloid cell apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. + GOC:add + GOC:mtg_apoptosis + @@ -44873,8 +66434,16 @@ + Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process. positive regulation of myeloid cell apoptotic process + + + + Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process. + GOC:add + GOC:mtg_apoptosis + @@ -44882,8 +66451,15 @@ + Any process in which a macromolecule is transported to, or maintained in, a specific location. macromolecule localization + + + + Any process in which a macromolecule is transported to, or maintained in, a specific location. + GOC:mah + @@ -44908,8 +66484,15 @@ + Any process in which a polysaccharide is transported to, or maintained in, a specific location. polysaccharide localization + + + + Any process in which a polysaccharide is transported to, or maintained in, a specific location. + GOC:mah + @@ -44934,8 +66517,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. regulation of organelle organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. + GOC:mah + @@ -44960,8 +66550,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. regulation of chromosome organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. + GOC:mah + @@ -44987,8 +66584,15 @@ + Any process that modulates the frequency, rate or extent of sister chromatid segregation. regulation of sister chromatid segregation + + + + Any process that modulates the frequency, rate or extent of sister chromatid segregation. + GOC:mah + @@ -45015,8 +66619,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation. negative regulation of sister chromatid segregation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation. + GOC:mah + @@ -45041,8 +66652,15 @@ + Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis. regulation of mitotic sister chromatid segregation + + + + Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis. + GOC:mah + @@ -45068,8 +66686,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis. negative regulation of mitotic sister chromatid segregation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis. + GOC:mah + @@ -45078,8 +66703,15 @@ + The deposition or aggregation of coloring matter in a cell. cellular pigmentation + + + + The deposition or aggregation of coloring matter in a cell. + GOC:mtg_MIT_16mar07 + @@ -45105,8 +66737,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. regulation of intracellular protein transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. + GOC:mah + @@ -45131,8 +66770,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. regulation of amine metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. + GOC:mah + @@ -45158,8 +66804,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. negative regulation of amine metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. + GOC:mah + @@ -45185,8 +66838,116 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. positive regulation of amine metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + regulation of amine catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + negative regulation of amine catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + positive regulation of amine catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. + GOC:mah + @@ -45217,8 +66978,16 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. cell proliferation in midbrain + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. + GOC:dgf + GO_REF:0000021 + @@ -45249,8 +67018,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. secretory granule organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. + GOC:mah + @@ -45275,8 +67051,15 @@ + A process in which a protein is transported to, or maintained in, a location within an organelle. protein localization to organelle + + + + A process in which a protein is transported to, or maintained in, a location within an organelle. + GOC:mah + @@ -45301,8 +67084,15 @@ + A process in which a protein is transported to, or maintained in, a location within a secretory granule. protein localization to secretory granule + + + + A process in which a protein is transported to, or maintained in, a location within a secretory granule. + GOC:mah + @@ -45331,8 +67121,48 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. T cell secretory granule organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. + carbohydrate homeostasis + + + + + A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. + GOC:mah + @@ -45359,8 +67189,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. negative regulation of catecholamine secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. + GOC:mah + @@ -45387,8 +67224,15 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. positive regulation of catecholamine secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. + GOC:mah + @@ -45413,8 +67257,15 @@ + A process in which a ribosome is transported to, and/or maintained in, a specific location. ribosome localization + + + + A process in which a ribosome is transported to, and/or maintained in, a specific location. + GOC:mah + @@ -45439,8 +67290,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. response to glucagon + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. + GOC:sl + @@ -45465,8 +67323,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. response to lipid + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. + GOC:sl + @@ -45491,8 +67356,15 @@ + A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. protein localization to Golgi apparatus + + + + A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. + GOC:mah + @@ -45517,8 +67389,17 @@ + Any process of regulating the production and elimination of erythrocytes within an organism. erythrocyte homeostasis + + + + Any process of regulating the production and elimination of erythrocytes within an organism. + GOC:add + PMID:10694114 + PMID:14754397 + @@ -45543,8 +67424,15 @@ + Any process that modulates the frequency, rate, or extent of tissue remodeling. regulation of tissue remodeling + + + + Any process that modulates the frequency, rate, or extent of tissue remodeling. + GOC:add + @@ -45570,8 +67458,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. negative regulation of tissue remodeling + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. + GOC:add + @@ -45597,8 +67492,15 @@ + Any process that activates or increases the frequency, rate, or extent of tissue remodeling. positive regulation of tissue remodeling + + + + Any process that activates or increases the frequency, rate, or extent of tissue remodeling. + GOC:add + @@ -45622,8 +67524,16 @@ + The process in which a carbohydrate is transported across a membrane. + Note that this term is not intended for use in annotating lateral movement within membranes. carbohydrate transmembrane transport + + + + The process in which a carbohydrate is transported across a membrane. + GOC:mah + @@ -45647,8 +67557,16 @@ + A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + Note that this term is not intended for use in annotating lateral movement within membranes. monoatomic ion transmembrane transport + + + + A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + GOC:mah + @@ -45675,8 +67593,15 @@ + Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. negative regulation of syncytium formation by plasma membrane fusion + + + + Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. + GOC:mah + @@ -45701,8 +67626,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. regulation of amide metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. + GOC:mah + @@ -45728,8 +67660,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. negative regulation of amide metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. + GOC:mah + @@ -45755,8 +67694,116 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. positive regulation of amide metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + regulation of amide catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + negative regulation of amide catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + positive regulation of amide catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. + GOC:mah + @@ -45781,8 +67828,15 @@ + A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. cell junction assembly + + + + A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. + GOC:mah + @@ -45807,8 +67861,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. cell junction organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. + GOC:dph + GOC:jl + GOC:mah + @@ -45833,8 +67896,17 @@ + Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system. glial cell apoptotic process + + + + Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system. + CL:0000125 + GOC:mtg_apoptosis + GOC:sart + @@ -45859,8 +67931,16 @@ + Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. regulation of glial cell apoptotic process + + + + Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. + GOC:mah + GOC:mtg_apoptosis + @@ -45886,8 +67966,16 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process. negative regulation of glial cell apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process. + GOC:mah + GOC:mtg_apoptosis + @@ -45913,8 +68001,16 @@ + Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process. positive regulation of glial cell apoptotic process + + + + Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process. + GOC:mah + GOC:mtg_apoptosis + @@ -45939,8 +68035,19 @@ + Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. smooth muscle cell apoptotic process + + + + Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. + CL:0000192 + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + GOC:rl + @@ -45965,8 +68072,17 @@ + Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. regulation of smooth muscle cell apoptotic process + + + + Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + GOC:rl + @@ -45992,8 +68108,17 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. negative regulation of smooth muscle cell apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + GOC:rl + @@ -46019,8 +68144,17 @@ + Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process. positive regulation of smooth muscle cell apoptotic process + + + + Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + GOC:rl + @@ -46045,8 +68179,17 @@ + The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. glycoprotein transport + + + + The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:BHF + GOC:mah + GOC:rl + @@ -46075,8 +68218,16 @@ + The process in which a solute is transported from one side of the vacuolar membrane to the other. + Note that this term is not intended for use in annotating lateral movement within membranes. vacuolar transmembrane transport + + + + The process in which a solute is transported from one side of the vacuolar membrane to the other. + GOC:mah + @@ -46101,8 +68252,15 @@ + Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. protein localization to chromosome + + + + Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. + GOC:mah + @@ -46127,8 +68285,15 @@ + A process in which a protein transports or maintains the localization of another protein to the nucleus. protein localization to nucleus + + + + A process in which a protein transports or maintains the localization of another protein to the nucleus. + GOC:ecd + @@ -46153,8 +68318,48 @@ + The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. nucleobase-containing compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. + nucleobase-containing compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:mah + @@ -46180,8 +68385,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. regulation of transmembrane transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. + GOC:mah + @@ -46208,8 +68420,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. negative regulation of transmembrane transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. + GOC:mah + @@ -46236,8 +68455,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. positive regulation of transmembrane transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. + GOC:mah + @@ -46263,8 +68489,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. regulation of monoatomic ion transmembrane transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. + GOC:mah + @@ -46291,8 +68524,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. negative regulation of monoatomic ion transmembrane transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. + GOC:mah + @@ -46319,8 +68559,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. positive regulation of monoatomic ion transmembrane transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. + GOC:mah + @@ -46345,8 +68592,17 @@ + The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion. + Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer. basement membrane disassembly + + + + The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion. + GOC:sart + PMID:17301221 + @@ -46384,8 +68640,15 @@ + The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. embryonic heart tube development + + + + The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. + GOC:go_curators + @@ -46416,8 +68679,15 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. cardiocyte differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. + GOC:bf + @@ -46449,8 +68719,19 @@ + The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. + Note that cilia and eukaryotic flagella are deemed to be equivalent. axoneme assembly + + + + The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. + GOC:bf + GOC:cilia + GOC:jl + ISBN:0815316194 + @@ -46481,8 +68762,15 @@ + The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. appendage morphogenesis + + + + The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. + ISBN:0582227089 + @@ -46514,8 +68802,15 @@ + The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. genitalia morphogenesis + + + + The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. + GOC:bf + @@ -46546,8 +68841,15 @@ + Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. tube formation + + + + Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. + GOC:bf + @@ -46578,8 +68880,17 @@ + The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex. syncytial nuclear migration + + + + The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex. + GOC:bf + ISBN:0879694238 + PMID:8314839 + @@ -46605,8 +68916,15 @@ + Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. ectopic germ cell programmed cell death + + + + Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. + PMID:12814944 + @@ -46637,8 +68955,16 @@ + The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. tube morphogenesis + + + + The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + GOC:bf + PMID:14624839 + @@ -46663,8 +68989,16 @@ + The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. internal genitalia morphogenesis + + + + The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. + PMID:24793987 + PMID:25247640 + @@ -46689,8 +69023,16 @@ + The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. external genitalia morphogenesis + + + + The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. + PMID:24793987 + PMID:25247640 + @@ -46722,8 +69064,15 @@ + The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals. gonad morphogenesis + + + + The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals. + ISBN:0198612001 + @@ -46749,8 +69098,18 @@ + The increase in size or mass of an entire multicellular organism, as opposed to cell growth. multicellular organism growth + + + + The increase in size or mass of an entire multicellular organism, as opposed to cell growth. + GOC:bf + GOC:curators + GOC:dph + GOC:tb + @@ -46776,8 +69135,17 @@ + The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. organ growth + + + + The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. + GOC:bf + ISBN:0471245208 + ISBN:0721662544 + @@ -46802,8 +69170,16 @@ + Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. endocrine system development + + + + Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. + GOC:bf + Wikipedia:Development_of_the_endocrine_system + @@ -46828,8 +69204,16 @@ + Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. exocrine system development + + + + Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. + GOC:bf + Wikipedia:Exocrine_gland + @@ -46837,8 +69221,17 @@ + The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. + Wikipedia:Segmentation_(biology) segmentation + + + + The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. + PMID:10611687 + PMID:9706689 + @@ -46852,8 +69245,15 @@ + Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. trunk segmentation + + + + Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. + PMID:1360402 + @@ -46884,8 +69284,15 @@ + The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. tube development + + + + The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. + PMID:12526790 + @@ -46910,8 +69317,16 @@ + A process in which a protein is transported to, or maintained at, a microtubule. protein localization to microtubule + + + + A process in which a protein is transported to, or maintained at, a microtubule. + GOC:bf + GOC:lb + @@ -46936,8 +69351,15 @@ + Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. protein localization to synapse + + + + Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. + GOC:bf + @@ -46962,8 +69384,15 @@ + The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes. cell migration involved in vasculogenesis + + + + The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes. + GOC:dgh + @@ -46988,8 +69417,18 @@ + The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. intracellular signal transduction + + + + The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. + GOC:bf + GOC:jl + GOC:signaling + ISBN:3527303782 + @@ -47021,8 +69460,16 @@ + The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. azurophil granule membrane + + + + The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. + GOC:bf + PMID:17152095 + @@ -47042,8 +69489,129 @@ + The directed movement of a protein to a specific location within the extracellular region. establishment of protein localization to extracellular region + + + + The directed movement of a protein to a specific location within the extracellular region. + GOC:BHF + GOC:bf + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). + intrahepatic bile duct development + + + + + The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). + GOC:bf + PMID:20614624 + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct. + cystic duct development + + + + + The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct. + PMID:20614624 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine. + enteric smooth muscle cell differentiation + + + + + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine. + CL:0002504 + GOC:BHF + @@ -47068,8 +69636,17 @@ + The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. hematopoietic stem cell migration + + + + The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. + CL:0000037 + GOC:BHF + PMID:20234092 + @@ -47095,8 +69672,17 @@ + The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. monocyte homeostasis + + + + The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. + CL:0000576 + GOC:BHF + PMID:18832716 + @@ -47121,8 +69707,16 @@ + The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly. intraciliary transport involved in cilium assembly + + + + The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly. + GOC:bf + GOC:cilia + @@ -47147,8 +69741,16 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis. cell proliferation involved in compound eye morphogenesis + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis. + GOC:bf + GOC:sart + @@ -47168,8 +69770,86 @@ + The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). endothelial cell chemotaxis + + + + The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). + CL:0000115 + GOC:BHF + + + + + + + + + + + + + + + + + + + + + + + + + + The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus. + insulin secretion involved in cellular response to glucose stimulus + + + + + The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus. + GOC:bf + GOC:yaf + PMID:8492079 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + positive regulation of insulin secretion involved in cellular response to glucose stimulus + + + + + Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + GOC:bf + GOC:yaf + @@ -47200,8 +69880,16 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells). angioblast cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells). + CL:0000566 + GOC:yaf + @@ -47238,8 +69926,62 @@ + A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. egg coat + + + + A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. + PMID:16944418 + PMID:17163408 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates. + cloaca development + + + + + The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates. + GOC:dgh + ISBN:0582227089 + @@ -47270,8 +70012,17 @@ + The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. megakaryocyte development + + + + The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. + CL:0000556 + GOC:BHF + GOC:vk + @@ -47285,8 +70036,18 @@ + A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. + Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone. ciliary transition zone + + + + A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. + GOC:cilia + GOC:kmv + PMID:21422230 + @@ -47311,8 +70072,16 @@ + The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. enteroendocrine cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. + CL:0000164 + GOC:bf + @@ -47343,8 +70112,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. vascular associated smooth muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. + GOC:sl + PMID:16151017 + PMID:18267954 + @@ -47369,8 +70147,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta. aortic smooth muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta. + GOC:sl + @@ -47395,8 +70180,19 @@ + The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. aorta development + + + + The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. + GOC:bf + GOC:dgh + MA:0000062 + UBERON:0000947 + Wikipedia:Aorta + @@ -47427,8 +70223,19 @@ + The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. ascending aorta development + + + + The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. + GOC:bf + GOC:dgh + MA:0002570 + UBERON:0001496 + Wikipedia:Ascending_aorta + @@ -47459,8 +70266,19 @@ + The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. descending aorta development + + + + The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. + GOC:bf + GOC:dgh + MA:0002571 + UBERON:0001514 + Wikipedia:Descending_aorta + @@ -47485,8 +70303,19 @@ + The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. dorsal aorta development + + + + The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. + GOC:bf + GOC:dgh + UBERON:0005805 + Wikipedia:Aorta + ZFA:0000014 + @@ -47517,8 +70346,19 @@ + The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. aorta morphogenesis + + + + The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. + GOC:bf + GOC:dgh + MA:0000062 + UBERON:0000947 + Wikipedia:Aorta + @@ -47555,8 +70395,19 @@ + The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. ascending aorta morphogenesis + + + + The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. + GOC:bf + GOC:dgh + MA:0002570 + UBERON:0001496 + Wikipedia:Ascending_aorta + @@ -47593,8 +70444,19 @@ + The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. descending aorta morphogenesis + + + + The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. + GOC:bf + GOC:dgh + MA:0002571 + UBERON:0001514 + Wikipedia:Descending_aorta + @@ -47625,8 +70487,19 @@ + The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. dorsal aorta morphogenesis + + + + The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. + GOC:bf + GOC:dgh + UBERON:0005805 + Wikipedia:Aorta + ZFA:0000014 + @@ -47657,8 +70530,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. skeletal muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. + CL:0000188 + GOC:BHF + GOC:vk + @@ -47684,8 +70566,15 @@ + The regulated release of any steroid that acts as a hormone into the circulatory system. steroid hormone secretion + + + + The regulated release of any steroid that acts as a hormone into the circulatory system. + GOC:sl + @@ -47693,8 +70582,15 @@ + The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates. androgen secretion + + + + The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates. + GOC:sl + @@ -47725,8 +70621,17 @@ + The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. endodermal cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. + CL:0000223 + GOC:yaf + PMID:17624332 + @@ -47751,8 +70656,17 @@ + The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. tendon development + + + + The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. + GOC:yaf + PMID:21412429 + UBERON:0000043 + @@ -47783,8 +70697,17 @@ + The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts. tendon formation + + + + The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts. + GOC:yaf + PMID:17567668 + UBERON:0000043 + @@ -47816,8 +70739,17 @@ + The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. osteoclast development + + + + The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. + CL:0000092 + GOC:bf + GOC:yaf + @@ -47825,8 +70757,15 @@ + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. direct ossification + + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. + GO_REF:0000034 + @@ -47857,8 +70796,16 @@ + The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. germ cell proliferation + + + + The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. + CL:0000586 + GOC:kmv + @@ -47883,8 +70830,18 @@ + The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. dendritic cell homeostasis + + + + The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. + CL:0000451 + GOC:uh + PMID:12570827 + PMID:19176316 + @@ -47915,8 +70872,16 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes. osteoclast maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes. + CL:0000092 + GOC:pg + @@ -47941,8 +70906,18 @@ + A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. muscle cell projection + + + + A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. + CL:0000187 + GOC:kmv + PMID:15930100 + PMID:22464329 + @@ -47967,8 +70942,18 @@ + The portion of the plasma membrane surrounding a muscle cell projection. muscle cell projection membrane + + + + The portion of the plasma membrane surrounding a muscle cell projection. + CL:0000187 + GOC:kmv + PMID:15930100 + PMID:22464329 + @@ -47993,8 +70978,16 @@ + The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. granulocyte activation + + + + The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + CL:0000094 + GOC:nhn + @@ -48002,8 +70995,51 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. + This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. response to decreased oxygen levels + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. + GOC:al + + + + + + + + + + + + + + + + + + + + + + + + + + Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules. + hepatocyte homeostasis + + + + + Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules. + CL:0000182 + GOC:nhn + PMID:19878874 + @@ -48028,8 +71064,17 @@ + Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells. epidermal stem cell homeostasis + + + + Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells. + CL:1000428 + GOC:nhn + PMID:17666529 + @@ -48054,8 +71099,64 @@ + The movement of a dendritic cell within or between different tissues and organs of the body. dendritic cell migration + + + + The movement of a dendritic cell within or between different tissues and organs of the body. + CL:0000451 + GOC:nhn + PMID:19339990 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. + post-anal tail morphogenesis + + + + + The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. + GOC:bf + GOC:kmv + Wikipedia:Chordate + @@ -48069,8 +71170,16 @@ + The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. somatodendritic compartment + + + + The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. + GOC:PARL + GOC:pad + @@ -48101,8 +71210,18 @@ + The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo. trunk neural crest cell migration + + + + The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo. + GOC:PARL + GOC:bf + GOC:mat + PMID:2387238 + @@ -48133,8 +71252,17 @@ + The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane. Golgi membrane fusion + + + + The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane. + GOC:PARL + GOC:bf + PMID:12473691 + @@ -48154,8 +71282,17 @@ + The increase in size or mass of an entire organism, a part of an organism or a cell. + See also the biological process term 'cell growth ; GO:0016049'. growth + + + + The increase in size or mass of an entire organism, a part of an organism or a cell. + GOC:bf + GOC:ma + @@ -48180,8 +71317,16 @@ + Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. regulation of growth + + + + Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. + GOC:ems + GOC:mah + @@ -48215,8 +71360,15 @@ + Self-propelled movement of a cell or organism from one location to another. locomotion + + + + Self-propelled movement of a cell or organism from one location to another. + GOC:dgh + @@ -48241,8 +71393,15 @@ + Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. regulation of locomotion + + + + Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. + GOC:ems + @@ -48268,8 +71427,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. negative regulation of locomotion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. + GOC:go_curators + @@ -48295,8 +71461,17 @@ + Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. regulation of multicellular organism growth + + + + Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. + GOC:dph + GOC:ems + GOC:tb + @@ -48323,8 +71498,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. negative regulation of multicellular organism growth + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. + GOC:dph + GOC:ems + GOC:tb + @@ -48338,8 +71522,16 @@ + The first few specialized divisions of an activated animal egg. embryonic cleavage + + + + The first few specialized divisions of an activated animal egg. + GOC:clt + ISBN:0070524300 + @@ -48365,8 +71557,15 @@ + Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. positive regulation of locomotion + + + + Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. + GOC:go_curators + @@ -48393,8 +71592,17 @@ + Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. positive regulation of multicellular organism growth + + + + Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. + GOC:dph + GOC:go_curators + GOC:tb + @@ -48421,8 +71629,15 @@ + Any process that activates or increases the frequency, rate or extent of embryonic development. positive regulation of embryonic development + + + + Any process that activates or increases the frequency, rate or extent of embryonic development. + GOC:go_curators + @@ -48449,8 +71664,16 @@ + Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. regulation of meiotic nuclear division + + + + Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. + GOC:ems + GOC:ma + @@ -48458,8 +71681,15 @@ + Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. regulation of development, heterochronic + + + + Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. + PMID:9442909 + @@ -48484,8 +71714,16 @@ + The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. gliogenesis + + + + The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. + GOC:dgh + GOC:jid + @@ -48516,8 +71754,17 @@ + Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. glial cell growth + + + + Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. + GOC:dph + GOC:isa_complete + GOC:jid + @@ -48543,8 +71790,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. regulation of catecholamine metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. + GOC:go_curators + @@ -48752,8 +72006,21 @@ + The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. + Wikipedia:Intraflagellar_transport + Note that we deem cilium and microtubule-based flagellum to be equivalent. intraciliary transport + + + + The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. + GOC:cilia + GOC:kmv + PMID:17981739 + PMID:18180368 + PMID:22869374 + @@ -48778,8 +72045,16 @@ + The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). cell migration involved in gastrulation + + + + The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). + GOC:jl + PMID:16099638 + @@ -48810,8 +72085,16 @@ + The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. germ-line stem cell division + + + + The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. + GOC:jid + PMID:2279698 + @@ -48837,8 +72120,15 @@ + The expansion of a T cell population by cell division. Follows T cell activation. T cell proliferation + + + + The expansion of a T cell population by cell division. Follows T cell activation. + GOC:jl + @@ -48865,8 +72155,15 @@ + Any process that activates or increases the rate or extent of T cell proliferation. positive regulation of T cell proliferation + + + + Any process that activates or increases the rate or extent of T cell proliferation. + GOC:ai + @@ -48892,8 +72189,15 @@ + Any process that activates or increases the rate or extent of resting T cell proliferation. positive regulation of T cell homeostatic proliferation + + + + Any process that activates or increases the rate or extent of resting T cell proliferation. + GOC:jl + @@ -48918,8 +72222,16 @@ + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. T cell activation + + + + The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. + GOC:mgi_curators + ISBN:0781735149 + @@ -48944,8 +72256,17 @@ + A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. macrophage activation + + + + A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + GOC:mgi_curators + ISBN:0781735149 + PMID:14506301 + @@ -48970,8 +72291,16 @@ + The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. monocyte activation + + + + The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + GOC:mgi_curators + ISBN:0781735149 + @@ -48996,8 +72325,18 @@ + The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. endothelial cell activation + + + + The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + GOC:mgi_curators + ISBN:0781735149 + PMID:12851652 + PMID:14581484 + @@ -49048,8 +72387,15 @@ + Any process that modulates the frequency, rate or extent of cell proliferation. regulation of cell population proliferation + + + + Any process that modulates the frequency, rate or extent of cell proliferation. + GOC:jl + @@ -49075,8 +72421,15 @@ + Any process that modulates the frequency, rate or extent of T cell proliferation. regulation of T cell proliferation + + + + Any process that modulates the frequency, rate or extent of T cell proliferation. + GOC:jl + @@ -49103,8 +72456,15 @@ + Any process that stops, prevents or reduces the rate or extent of T cell proliferation. negative regulation of T cell proliferation + + + + Any process that stops, prevents or reduces the rate or extent of T cell proliferation. + GOC:jl + @@ -49129,8 +72489,15 @@ + The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. lipoprotein metabolic process + + + + The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. + ISBN:0198506732 + @@ -49155,8 +72522,48 @@ + The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. lipoprotein biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. + lipoprotein catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. + ISBN:0198506732 + @@ -49170,8 +72577,196 @@ + The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. nuclear outer membrane-endoplasmic reticulum membrane network + + + + The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. + GOC:bf + GOC:jl + GOC:mah + GOC:mcc + GOC:pr + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + regulation of protein catabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + GOC:go_curators + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. + negative regulation of protein catabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. + GOC:TermGenie + GOC:kmv + GOC:obol + GO_REF:0000058 + PMID:24785082 + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + cellular ketone metabolic process + + + + + The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:jl + ISBN:0787650153 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + ketone biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + ketone catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. + GOC:go_curators + @@ -49196,8 +72791,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to chemical + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + GOC:jl + @@ -49205,8 +72808,17 @@ + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. ribosome biogenesis + + + + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. + GOC:ma + PMID:26404467 + Wikipedia:Ribosome_biogenesis + @@ -49237,8 +72849,16 @@ + The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. ribosome assembly + + + + The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. + GOC:ma + PMID:30467428 + @@ -49252,8 +72872,17 @@ + The directed movement of a motile cell or organism in response to an external stimulus. + Wikipedia:Taxis taxis + + + + The directed movement of a motile cell or organism in response to an external stimulus. + GOC:jl + ISBN:0192801023 + @@ -49266,8 +72895,18 @@ + Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. regulation of membrane potential + + + + Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. + GOC:jl + GOC:mtg_cardio + GOC:tb + ISBN:0198506732 + @@ -49276,8 +72915,34 @@ + The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. biogenic amine biosynthetic process + + + + The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. + GOC:jl + ISBN:0395825172 + + + + + + + + + The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. + cellular biogenic amine catabolic process + + + + + The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. + GOC:go_curators + GOC:jl + ISBN:0198506732 + @@ -49302,8 +72967,16 @@ + The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. norepinephrine metabolic process + + + + The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. + GOC:jl + ISBN:0198506732 + @@ -49328,8 +73001,51 @@ + The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. norepinephrine biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. + Wikipedia:Norepinephrine#Degradation + norepinephrine catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. + GOC:jl + ISBN:0198506732 + @@ -49354,8 +73070,51 @@ + The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + Wikipedia:Catecholamines catecholamine biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + catecholamine catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:jl + ISBN:0198506732 + @@ -49380,8 +73139,17 @@ + The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + Wikipedia:Serotonin serotonin biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + GOC:jl + ISBN:0198506732 + @@ -49409,8 +73177,50 @@ + The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. serotonin metabolic process + + + + The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + serotonin catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. + GOC:jl + ISBN:0198506732 + @@ -49435,8 +73245,16 @@ + The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. indole-containing compound metabolic process + + + + The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. + GOC:jl + GOC:mah + @@ -49462,8 +73280,48 @@ + The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. indole-containing compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. + indole-containing compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. + GOC:jl + @@ -49494,8 +73352,15 @@ + Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. photoreceptor cell development + + + + Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. + GOC:go_curators + @@ -49526,8 +73391,16 @@ + Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. eye photoreceptor cell development + + + + Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. + GOC:jl + ISBN:0192800981 + @@ -49553,8 +73426,15 @@ + Any process that modulates the frequency, rate or extent of eye photoreceptor development. regulation of eye photoreceptor cell development + + + + Any process that modulates the frequency, rate or extent of eye photoreceptor development. + GOC:jl + @@ -49581,8 +73461,15 @@ + Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. positive regulation of eye photoreceptor cell development + + + + Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. + GOC:jl + @@ -49608,8 +73495,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development. negative regulation of eye photoreceptor cell development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development. + GOC:jl + @@ -49640,8 +73534,16 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. neuron maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. + GOC:dph + GOC:jl + @@ -49650,8 +73552,75 @@ + Primary lysosomal granule readily stainable with a Romanowsky stain. azurophil granule + + + + Primary lysosomal granule readily stainable with a Romanowsky stain. + GOC:jl + PMID:17152095 + PMID:28717070 + PMID:5914694 + WIKIPEDIA:Azurophilic_granule + + + + + + + + + A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. + zymogen granule + + + + + A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The lipid bilayer surrounding a zymogen granule. + zymogen granule membrane + + + + + The lipid bilayer surrounding a zymogen granule. + GOC:jl + @@ -49659,8 +73628,49 @@ + Any biological process involved in the maintenance of an internal steady state. homeostatic process + + + + Any biological process involved in the maintenance of an internal steady state. + GOC:jl + ISBN:0395825172 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. + glucose homeostasis + + + + + Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. + GOC:go_curators + @@ -49668,8 +73678,19 @@ + A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. MHC protein complex + + + + A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. + GOC:add + GOC:jl + ISBN:0781735149 + PMID:15928678 + PMID:16153240 + @@ -49677,8 +73698,18 @@ + A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. MHC class II protein complex + + + + A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. + GOC:add + GOC:jl + ISBN:0120781859 + PMID:15928678 + @@ -49692,8 +73723,15 @@ + Any complex of actin, myosin, and accessory proteins. actomyosin + + + + Any complex of actin, myosin, and accessory proteins. + GOC:go_curators + @@ -49718,8 +73756,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. retinal cone cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. + GOC:go_curators + @@ -49750,8 +73795,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. + CL:0000187 + GOC:go_curators + @@ -49771,8 +73824,15 @@ + Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. defense response to bacterium + + + + Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. + GOC:jl + @@ -49797,8 +73857,56 @@ + The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. amide transport + + + + The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. + amide transmembrane transporter activity + + + + + Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. + GOC:jl + ISBN:0198506732 + @@ -49818,8 +73926,16 @@ + The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. lipoprotein transport + + + + The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + ISBN:0198506732 + @@ -49870,8 +73986,17 @@ + Any process that modulates the occurrence or rate of cell death by apoptotic process. + This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. regulation of apoptotic process + + + + Any process that modulates the occurrence or rate of cell death by apoptotic process. + GOC:jl + GOC:mtg_apoptosis + @@ -49885,8 +74010,16 @@ + A prolongation or process extending from a cell, e.g. a flagellum or axon. cell projection + + + + A prolongation or process extending from a cell, e.g. a flagellum or axon. + GOC:jl + PMID:16318917 + @@ -49913,8 +74046,15 @@ + Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. regulation of Golgi to plasma membrane protein transport + + + + Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. + GOC:jl + @@ -49941,8 +74081,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. negative regulation of Golgi to plasma membrane protein transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. + GOC:jl + @@ -49969,8 +74116,15 @@ + Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. positive regulation of Golgi to plasma membrane protein transport + + + + Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. + GOC:jl + @@ -49999,8 +74153,15 @@ + The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. Golgi to plasma membrane protein transport + + + + The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. + ISBN:0716731363 + @@ -50051,8 +74212,17 @@ + A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. + NIF_Subcellular:sao867568886 neuron projection + + + + A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. + GOC:jl + PMID:3077060 + @@ -50072,8 +74242,15 @@ + The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. chordate embryonic development + + + + The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. + GOC:mtg_sensu + @@ -50124,8 +74301,16 @@ + The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. camera-type eye development + + + + The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. + GOC:go_curators + GOC:mtg_sensu + @@ -50152,8 +74337,17 @@ + The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. + Wikipedia:Dendritic_cell myeloid dendritic cell differentiation + + + + The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. + CL:0000782 + GOC:jl + @@ -50178,8 +74372,18 @@ + The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. + NIF_Subcellular:sao1044911821 + Wikipedia:Soma_(biology) + Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. neuronal cell body + + + + The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. + GOC:go_curators + @@ -50204,8 +74408,17 @@ + The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. + Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus. T cell homeostasis + + + + The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. + GOC:mgi_curators + ISBN:0781735149 + @@ -50230,8 +74443,15 @@ + Any process that modulates the frequency or rate of macrophage activation. regulation of macrophage activation + + + + Any process that modulates the frequency or rate of macrophage activation. + GOC:jl + @@ -50257,8 +74477,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation. negative regulation of macrophage activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation. + GOC:jl + @@ -50284,8 +74511,15 @@ + Any process that stimulates, induces or increases the rate of macrophage activation. positive regulation of macrophage activation + + + + Any process that stimulates, induces or increases the rate of macrophage activation. + GOC:jl + @@ -50310,8 +74544,16 @@ + The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. peptide biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. + GOC:dph + GOC:jl + @@ -50336,8 +74578,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. extracellular structure organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. + GOC:ai + GOC:dph + GOC:jl + GOC:mah + @@ -50363,8 +74615,17 @@ + Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. + This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. positive regulation of apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. + GOC:jl + GOC:mtg_apoptosis + @@ -50396,8 +74657,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. + This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. negative regulation of apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. + GOC:jl + GOC:mtg_apoptosis + @@ -50422,8 +74692,15 @@ + Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. regulation of programmed cell death + + + + Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. + GOC:jl + @@ -50449,8 +74726,15 @@ + Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. positive regulation of programmed cell death + + + + Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. + GOC:jl + @@ -50476,8 +74760,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. negative regulation of programmed cell death + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. + GOC:jl + @@ -50502,8 +74793,90 @@ + The nucleus of a germ cell, a reproductive cell in multicellular organisms. germ cell nucleus + + + + The nucleus of a germ cell, a reproductive cell in multicellular organisms. + CL:0000586 + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the activity of an enzyme. + positive regulation of catalytic activity + + + + + Any process that activates or increases the activity of an enzyme. + GOC:ebc + GOC:jl + GOC:tb + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the activity of an enzyme. + negative regulation of catalytic activity + + + + + Any process that stops or reduces the activity of an enzyme. + GOC:ebc + GOC:jl + GOC:tb + GOC:vw + @@ -50511,8 +74884,87 @@ + Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid. surfactant homeostasis + + + + Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid. + PMID:23708874 + PMID:9751757 + + + + + + + + + + + + + + + + + + + + + + + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine. + hindgut contraction + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine. + GOC:jl + GOC:mtg_muscle + UBERON:0001046 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + regulation of hindgut contraction + + + + + Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + GOC:jl + UBERON:0001046 + @@ -50538,8 +74990,15 @@ + Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location. regulation of translation by machinery localization + + + + Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location. + GOC:jl + @@ -50564,8 +75023,48 @@ + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. macromolecule metabolic process + + + + The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. + peptide catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. + GOC:jl + @@ -50574,8 +75073,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. response to external biotic stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. + GOC:go_curators + @@ -50583,8 +75089,17 @@ + Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. + NIF_Subcellular:sao1539965131 + Wikipedia:Organelle organelle + + + + Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. + GOC:go_curators + @@ -50610,8 +75125,16 @@ + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + NIF_Subcellular:sao414196390 membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + GOC:go_curators + @@ -50619,8 +75142,16 @@ + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. + NIF_Subcellular:sao1456184038 non-membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. + GOC:go_curators + @@ -50646,8 +75177,15 @@ + Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. intracellular organelle + + + + Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + GOC:go_curators + @@ -50672,8 +75210,16 @@ + Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. extracellular organelle + + + + Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. + GOC:jl + PMID:9914479 + @@ -50693,8 +75239,15 @@ + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. intracellular membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. + GOC:go_curators + @@ -50714,8 +75267,15 @@ + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. intracellular non-membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. + GOC:go_curators + @@ -50740,8 +75300,16 @@ + The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. organelle lumen + + + + The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. + GOC:jl + GOC:mah + @@ -50767,8 +75335,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. negative regulation of protein-containing complex disassembly + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. + GOC:jl + @@ -50794,8 +75369,15 @@ + Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. positive regulation of protein-containing complex disassembly + + + + Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. + GOC:jl + @@ -50820,8 +75402,15 @@ + Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. regulation of protein-containing complex disassembly + + + + Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. + GOC:jl + @@ -50852,8 +75441,16 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. erythrocyte maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. + GOC:devbiol + GOC:jl + @@ -50879,8 +75476,15 @@ + Any process that modulates the frequency, rate or extent of protein complex assembly. regulation of protein-containing complex assembly + + + + Any process that modulates the frequency, rate or extent of protein complex assembly. + GOC:jl + @@ -50906,8 +75510,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. regulation of carbohydrate biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. + GOC:jl + @@ -50927,8 +75538,15 @@ + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. extracellular non-membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. + GOC:jl + @@ -50953,8 +75571,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of monoatomic ion transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + @@ -50980,8 +75605,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of monoatomic ion transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + @@ -51007,8 +75639,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of monoatomic ion transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:jl + @@ -51041,8 +75680,16 @@ + Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. contractile muscle fiber + + + + Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. + GOC:go_curators + ISBN:0815316194 + @@ -51073,8 +75720,16 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus. nucleate erythrocyte maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus. + GOC:devbiol + GOC:jl + @@ -51099,8 +75754,15 @@ + The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. nucleate erythrocyte differentiation + + + + The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. + GOC:jl + @@ -51125,8 +75787,116 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. response to peptide hormone + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. + PMID:11027914 + PMID:15134857 + Wikipedia:Peptide_hormone + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). + oxoacid metabolic process + + + + + The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). + Wikipedia:Oxyacid + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. + regulation of generation of precursor metabolites and energy + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. + regulation of carbohydrate catabolic process + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. + GOC:mlg + @@ -51146,8 +75916,15 @@ + The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. pigmentation + + + + The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. + GOC:jl + @@ -51162,8 +75939,18 @@ + A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. muscle adaptation + + + + A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. + GOC:mtg_muscle + PMID:11181628 + PMID:11449884 + PMID:12605307 + @@ -51188,8 +75975,18 @@ + Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. skeletal muscle adaptation + + + + Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. + GOC:mtg_muscle + PMID:11181628 + PMID:11449884 + PMID:12605307 + @@ -51215,8 +76012,16 @@ + Any process that modulates the frequency, rate or extent of muscle adaptation. regulation of muscle adaptation + + + + Any process that modulates the frequency, rate or extent of muscle adaptation. + GOC:go_curators + GOC:mtg_muscle + @@ -51241,8 +76046,16 @@ + Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. regulation of neuron apoptotic process + + + + Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. + GOC:go_curators + GOC:mtg_apoptosis + @@ -51268,8 +76081,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. negative regulation of neuron apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. + GOC:go_curators + GOC:mtg_apoptosis + @@ -51295,8 +76116,16 @@ + Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. positive regulation of neuron apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. + GOC:go_curators + GOC:mtg_apoptosis + @@ -51321,8 +76150,15 @@ + The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. blood vessel endothelial cell migration + + + + The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. + PMID:11166264 + @@ -51347,8 +76183,15 @@ + Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. regulation of blood vessel endothelial cell migration + + + + Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. + GOC:go_curators + @@ -51374,8 +76217,15 @@ + Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. positive regulation of blood vessel endothelial cell migration + + + + Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. + GOC:go_curators + @@ -51401,8 +76251,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. negative regulation of blood vessel endothelial cell migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. + GOC:go_curators + @@ -51427,8 +76284,15 @@ + The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. endothelial cell migration + + + + The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. + GOC:go_curators + @@ -51453,8 +76317,15 @@ + Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. regulation of respiratory gaseous exchange + + + + Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. + GOC:jl + @@ -51531,8 +76402,16 @@ + The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. skin development + + + + The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. + GOC:jl + UBERON:0002097 + @@ -51563,8 +76442,16 @@ + The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. skin morphogenesis + + + + The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. + GOC:jl + UBERON:0002097 + @@ -51589,8 +76476,16 @@ + The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. amide metabolic process + + + + The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. + GOC:curators + @@ -51616,8 +76511,48 @@ + The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. amide biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. + GOC:curators + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. + amide catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. + GOC:curators + @@ -51642,8 +76577,17 @@ + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state. ossification involved in bone maturation + + + + The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state. + GOC:dph + GOC:mah + GOC:mtg_mpo + @@ -51668,8 +76612,16 @@ + The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli. ossification involved in bone remodeling + + + + The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli. + GOC:mtg_mpo + GO_REF:0000034 + @@ -51694,8 +76646,48 @@ + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. protein-containing complex organization + + + + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. + glucan metabolic process + + + + + The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. + GOC:jl + @@ -51720,8 +76712,15 @@ + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. regulation of system process + + + + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. + GOC:jl + @@ -51746,8 +76745,15 @@ + Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. regulation of digestive system process + + + + Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:jl + @@ -51772,8 +76778,49 @@ + Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. regulation of endocrine process + + + + Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. + regulation of excretion + + + + + Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. + GOC:jl + @@ -51799,8 +76846,15 @@ + Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. regulation of respiratory system process + + + + Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. + GOC:jl + @@ -51808,8 +76862,16 @@ + A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. cellular component biogenesis + + + + A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. + GOC:jl + GOC:mah + @@ -51834,8 +76896,15 @@ + Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. regulation of cellular component biogenesis + + + + Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. + GOC:jl + @@ -51860,8 +76929,16 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. regulation of vacuole organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. + GOC:jl + GOC:mah + @@ -51887,8 +76964,15 @@ + Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. positive regulation of cellular component biogenesis + + + + Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. + GOC:jl + @@ -51914,8 +76998,16 @@ + Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. positive regulation of vacuole organization + + + + Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. + GOC:jl + GOC:mah + @@ -51940,8 +77032,81 @@ + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. membrane biogenesis + + + + A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + negative regulation of molecular function + + + + + Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GO:jl + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + positive regulation of molecular function + + + + + Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GO:jl + @@ -51955,8 +77120,15 @@ + A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). translation initiation ternary complex + + + + A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). + GOC:jl + @@ -51965,8 +77137,16 @@ + The chemical reactions and pathways by which individual cells transform chemical substances. + This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. cellular metabolic process + + + + The chemical reactions and pathways by which individual cells transform chemical substances. + GOC:go_curators + @@ -51974,8 +77154,33 @@ + The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + Wikipedia:Primary_metabolite primary metabolic process + + + + The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + GOC:go_curators + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + cellular catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. + GOC:jl + @@ -51984,8 +77189,108 @@ + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. cellular biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:jl + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas. + intestinal lipid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas. + GOC:jl + PMID:7018485 + + + + + + + + + The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. + Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. + small molecule metabolic process + + + + + The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. + GOC:curators + GOC:pde + GOC:vw + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. + Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. + small molecule catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. + GOC:curators + GOC:vw + + + + + + + + + + The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. + Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. + small molecule biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. + GOC:curators + GOC:pde + GOC:vw + @@ -52025,8 +77330,53 @@ + The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. + FBbt:00005107 + FMA:67301 + Wikipedia:Cell_body + Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. cell body + + + + The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. + type B pancreatic cell proliferation + + + + + The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. + GOC:jl + GOC:yaf + @@ -52051,8 +77401,18 @@ + Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. fibroblast apoptotic process + + + + Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. + CL:0000057 + GOC:jl + GOC:mtg_apoptosis + GOC:yaf + @@ -52077,8 +77437,15 @@ + A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. protein localization to cytoskeleton + + + + A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. + GOC:jl + @@ -52112,8 +77479,15 @@ + Any process evolved to enable an interaction with an organism of a different species. biological process involved in interspecies interaction between organisms + + + + Any process evolved to enable an interaction with an organism of a different species. + GOC:cc + @@ -52138,8 +77512,21 @@ + The aggregation, arrangement and bonding together of a set of components to form a motile cilium. motile cilium assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a motile cilium. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000079 + PMID:19776033 + PMID:21129373 + ZFIN:dsf + @@ -52164,8 +77551,16 @@ + The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. dendritic cell proliferation + + + + The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. + CL:0000451 + PMID:18469816 + @@ -52190,8 +77585,16 @@ + A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage. chondrocyte activation + + + + A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage. + CL:0000138 + GOC:jl + @@ -52199,8 +77602,15 @@ + A biological process that directly contributes to the process of producing new individuals, involving another organism. multi-organism reproductive process + + + + A biological process that directly contributes to the process of producing new individuals, involving another organism. + GOC:jl + @@ -52208,8 +77618,15 @@ + A multicellular organism process which involves another multicellular organism of the same or different species. multi-multicellular organism process + + + + A multicellular organism process which involves another multicellular organism of the same or different species. + GOC:jl + @@ -52247,8 +77664,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + Note that we deem cilium and microtubule-based flagellum to be equivalent. cilium organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + GOC:cilia + GOC:jl + @@ -52273,8 +77699,15 @@ + Any process in which a lipoprotein is transported to, or maintained in, a specific location. lipoprotein localization + + + + Any process in which a lipoprotein is transported to, or maintained in, a specific location. + GOC:jl + @@ -52294,8 +77727,15 @@ + A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane. lipoprotein localization to membrane + + + + A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane. + GOC:jl + @@ -52320,8 +77760,15 @@ + A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. lipoprotein localization to outer membrane + + + + A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. + GOC:jl + @@ -52347,8 +77794,16 @@ + The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. plasma membrane fusion + + + + The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. + GOC:elh + GOC:mtg_muscle + @@ -52373,8 +77828,15 @@ + Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). regulation of bone resorption + + + + Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). + GOC:ai + @@ -52400,8 +77862,16 @@ + The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. meiotic chromosome segregation + + + + The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. + GOC:ai + GOC:mah + @@ -52421,8 +77891,15 @@ + The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. development of primary sexual characteristics + + + + The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. + GOC:ai + @@ -52436,8 +77913,16 @@ + The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. + Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. cell fate commitment + + + + The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. + ISBN:0716731185 + @@ -52462,8 +77947,17 @@ + Signaling at long or short range between cells that results in the commitment of a cell to a certain fate. cell-cell signaling involved in cell fate commitment + + + + Signaling at long or short range between cells that results in the commitment of a cell to a certain fate. + GOC:dph + GOC:go_curators + GOC:tb + @@ -52489,8 +77983,15 @@ + The directed movement of a protein to a specific location. establishment of protein localization + + + + The directed movement of a protein to a specific location. + GOC:bf + @@ -52504,8 +78005,19 @@ + Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. establishment or maintenance of neuroblast polarity + + + + Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. + GOC:bf + GOC:mah + GOC:mtg_sensu + PMID:19375318 + PMID:20066083 + @@ -52531,8 +78043,16 @@ + The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. establishment of neuroblast polarity + + + + The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. + GOC:bf + GOC:mtg_sensu + @@ -52552,8 +78072,21 @@ + The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. + NIF_Subcellular:sao914572699 + Wikipedia:Chemical_synapse synapse + + + + The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. + GOC:aruk + ISBN:0198506732 + PMID:24619342 + PMID:29383328 + PMID:31998110 + @@ -52584,8 +78117,15 @@ + The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. sarcomere organization + + + + The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + GOC:bf + @@ -52610,8 +78150,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. cell-cell junction organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. + GOC:ai + GOC:dph + GOC:jl + GOC:mah + @@ -52636,8 +78186,16 @@ + The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions. CD4 biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions. + GOC:go_curators + ISBN:0198506732 + @@ -52662,8 +78220,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. regulation of CD4 production + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. + GOC:go_curators + @@ -52689,8 +78254,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. positive regulation of CD4 production + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. + GOC:go_curators + @@ -52716,8 +78288,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. negative regulation of CD4 production + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. + GOC:go_curators + @@ -52742,8 +78321,18 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. external encapsulating structure organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. + GOC:ai + GOC:dph + GOC:jl + GOC:mah + @@ -52781,8 +78370,16 @@ + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. + Wikipedia:Immunologic_activation leukocyte activation + + + + A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. + GOC:add + @@ -52807,8 +78404,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. fat cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. + CL:0000136 + GOC:go_curators + @@ -52839,8 +78444,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. myoblast differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. + CL:0000056 + GOC:go_curators + GOC:mtg_muscle + @@ -52871,8 +78485,16 @@ + The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. endothelial cell differentiation + + + + The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. + CL:0000115 + GOC:go_curators + @@ -52886,8 +78508,17 @@ + The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. + Wikipedia:Bone_resorption bone resorption + + + + The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. + GOC:mah + PMID:10968780 + @@ -52913,8 +78544,16 @@ + Any process that modulates the frequency, rate or extent of T cell differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. regulation of T cell differentiation + + + + Any process that modulates the frequency, rate or extent of T cell differentiation. + GOC:go_curators + @@ -52941,8 +78580,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. negative regulation of T cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. + GOC:go_curators + @@ -52969,8 +78616,16 @@ + Any process that activates or increases the frequency, rate or extent of T cell differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. positive regulation of T cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of T cell differentiation. + GOC:go_curators + @@ -52996,8 +78651,15 @@ + Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. regulation of cell differentiation + + + + Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. + GOC:go_curators + @@ -53024,8 +78686,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. negative regulation of cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. + GOC:go_curators + @@ -53052,8 +78721,15 @@ + Any process that activates or increases the frequency, rate or extent of cell differentiation. positive regulation of cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of cell differentiation. + GOC:go_curators + @@ -53078,8 +78754,15 @@ + Any process that modulates the frequency, rate or extent of adipocyte differentiation. regulation of fat cell differentiation + + + + Any process that modulates the frequency, rate or extent of adipocyte differentiation. + GOC:go_curators + @@ -53105,8 +78788,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. negative regulation of fat cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. + GOC:go_curators + @@ -53132,8 +78822,15 @@ + Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. positive regulation of fat cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. + GOC:go_curators + @@ -53158,8 +78855,15 @@ + Any process that modulates the frequency, rate or extent of endothelial cell differentiation. regulation of endothelial cell differentiation + + + + Any process that modulates the frequency, rate or extent of endothelial cell differentiation. + GOC:go_curators + @@ -53185,8 +78889,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. negative regulation of endothelial cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. + GOC:go_curators + @@ -53212,8 +78923,15 @@ + Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. positive regulation of endothelial cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. + GOC:go_curators + @@ -53239,8 +78957,15 @@ + Any process that modulates the frequency, rate or extent of epidermal cell differentiation. regulation of epidermal cell differentiation + + + + Any process that modulates the frequency, rate or extent of epidermal cell differentiation. + GOC:go_curators + @@ -53267,8 +78992,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. negative regulation of epidermal cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. + GOC:go_curators + @@ -53295,8 +79027,15 @@ + Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. positive regulation of epidermal cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. + GOC:go_curators + @@ -53322,8 +79061,16 @@ + Any process that modulates the frequency, rate or extent of lymphocyte differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. regulation of lymphocyte differentiation + + + + Any process that modulates the frequency, rate or extent of lymphocyte differentiation. + GOC:go_curators + @@ -53350,8 +79097,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. negative regulation of lymphocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. + GOC:go_curators + @@ -53378,8 +79133,16 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. + Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. positive regulation of lymphocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. + GOC:go_curators + @@ -53404,8 +79167,15 @@ + Any process that modulates the frequency, rate or extent of myeloid cell differentiation. regulation of myeloid cell differentiation + + + + Any process that modulates the frequency, rate or extent of myeloid cell differentiation. + GOC:go_curators + @@ -53431,8 +79201,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. negative regulation of myeloid cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. + GOC:go_curators + @@ -53458,8 +79235,15 @@ + Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. positive regulation of myeloid cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. + GOC:go_curators + @@ -53484,8 +79268,15 @@ + Any process that modulates the frequency, rate or extent of erythrocyte differentiation. regulation of erythrocyte differentiation + + + + Any process that modulates the frequency, rate or extent of erythrocyte differentiation. + GOC:go_curators + @@ -53511,8 +79302,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation. negative regulation of erythrocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation. + GOC:go_curators + @@ -53538,8 +79336,15 @@ + Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. positive regulation of erythrocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. + GOC:go_curators + @@ -53564,8 +79369,15 @@ + Any process that modulates the frequency, rate or extent of macrophage differentiation. regulation of macrophage differentiation + + + + Any process that modulates the frequency, rate or extent of macrophage differentiation. + GOC:go_curators + @@ -53591,8 +79403,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation. negative regulation of macrophage differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation. + GOC:go_curators + @@ -53618,8 +79437,15 @@ + Any process that activates or increases the frequency, rate or extent of macrophage differentiation. positive regulation of macrophage differentiation + + + + Any process that activates or increases the frequency, rate or extent of macrophage differentiation. + GOC:go_curators + @@ -53644,8 +79470,15 @@ + Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. regulation of megakaryocyte differentiation + + + + Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. + GOC:go_curators + @@ -53671,8 +79504,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. negative regulation of megakaryocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. + GOC:go_curators + @@ -53698,8 +79538,15 @@ + Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. positive regulation of megakaryocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. + GOC:go_curators + @@ -53724,8 +79571,15 @@ + Any process that modulates the frequency, rate or extent of monocyte differentiation. regulation of monocyte differentiation + + + + Any process that modulates the frequency, rate or extent of monocyte differentiation. + GOC:go_curators + @@ -53751,8 +79605,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation. negative regulation of monocyte differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation. + GOC:go_curators + @@ -53778,8 +79639,15 @@ + Any process that activates or increases the frequency, rate or extent of monocyte differentiation. positive regulation of monocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of monocyte differentiation. + GOC:go_curators + @@ -53804,8 +79672,17 @@ + Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. regulation of myoblast differentiation + + + + Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:go_curators + GOC:mtg_muscle + @@ -53831,8 +79708,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. negative regulation of myoblast differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:go_curators + GOC:mtg_muscle + @@ -53858,8 +79744,17 @@ + Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. positive regulation of myoblast differentiation + + + + Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:go_curators + GOC:mtg_muscle + @@ -53896,8 +79791,15 @@ + Any process that modulates the frequency, rate or extent of neuron differentiation. regulation of neuron differentiation + + + + Any process that modulates the frequency, rate or extent of neuron differentiation. + GOC:go_curators + @@ -53923,8 +79825,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. negative regulation of neuron differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. + GOC:go_curators + @@ -53950,8 +79859,15 @@ + Any process that activates or increases the frequency, rate or extent of neuron differentiation. positive regulation of neuron differentiation + + + + Any process that activates or increases the frequency, rate or extent of neuron differentiation. + GOC:go_curators + @@ -53976,8 +79892,15 @@ + Any process that modulates the frequency, rate or extent of osteoclast differentiation. regulation of osteoclast differentiation + + + + Any process that modulates the frequency, rate or extent of osteoclast differentiation. + GOC:go_curators + @@ -54003,8 +79926,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. negative regulation of osteoclast differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. + GOC:go_curators + @@ -54030,8 +79960,15 @@ + Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. positive regulation of osteoclast differentiation + + + + Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. + GOC:go_curators + @@ -54056,8 +79993,15 @@ + Any process that modulates the frequency, rate or extent of epidermis development. regulation of epidermis development + + + + Any process that modulates the frequency, rate or extent of epidermis development. + GOC:go_curators + @@ -54083,8 +80027,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. negative regulation of epidermis development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. + GOC:go_curators + @@ -54110,8 +80061,15 @@ + Any process that activates or increases the frequency, rate or extent of epidermis development. positive regulation of epidermis development + + + + Any process that activates or increases the frequency, rate or extent of epidermis development. + GOC:go_curators + @@ -54136,8 +80094,15 @@ + Any process that modulates the frequency, rate or extent of glia cell differentiation. regulation of glial cell differentiation + + + + Any process that modulates the frequency, rate or extent of glia cell differentiation. + GOC:go_curators + @@ -54163,8 +80128,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. negative regulation of glial cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. + GOC:go_curators + @@ -54190,8 +80162,119 @@ + Any process that activates or increases the frequency, rate or extent of glia cell differentiation. positive regulation of glial cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of glia cell differentiation. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + negative regulation of glycogen biosynthetic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. + negative regulation of gluconeogenesis + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of gluconeogenesis. + positive regulation of gluconeogenesis + + + + + Any process that activates or increases the frequency, rate or extent of gluconeogenesis. + GOC:go_curators + @@ -54218,8 +80301,51 @@ + Any process that activates or increases the frequency, rate or extent of the formation of a cilium. positive regulation of cilium assembly + + + + Any process that activates or increases the frequency, rate or extent of the formation of a cilium. + GOC:cilia + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + positive regulation of glycogen biosynthetic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. + GOC:go_curators + @@ -54246,8 +80372,51 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. positive regulation of translation + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. + GOC:dph + GOC:go_curators + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + positive regulation of protein catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. + GOC:go_curators + @@ -54273,8 +80442,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. negative regulation of action potential + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:go_curators + @@ -54300,8 +80476,15 @@ + Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. positive regulation of action potential + + + + Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:go_curators + @@ -54327,8 +80510,15 @@ + Any process that modulates the frequency, rate or extent of angiogenesis. regulation of angiogenesis + + + + Any process that modulates the frequency, rate or extent of angiogenesis. + GOC:go_curators + @@ -54354,8 +80544,15 @@ + Any process that activates or increases angiogenesis. positive regulation of angiogenesis + + + + Any process that activates or increases angiogenesis. + GOC:go_curators + @@ -54381,8 +80578,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division. negative regulation of asymmetric cell division + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division. + GOC:go_curators + @@ -54408,8 +80612,15 @@ + Any process that activates or increases the frequency, rate or extent of asymmetric cell division. positive regulation of asymmetric cell division + + + + Any process that activates or increases the frequency, rate or extent of asymmetric cell division. + GOC:go_curators + @@ -54435,8 +80646,15 @@ + Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. positive regulation of ossification + + + + Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. + GOC:go_curators + @@ -54462,8 +80680,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. negative regulation of bone resorption + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. + GOC:go_curators + @@ -54489,8 +80714,15 @@ + Any process that activates or increases the frequency, rate or extent of bone resorption. positive regulation of bone resorption + + + + Any process that activates or increases the frequency, rate or extent of bone resorption. + GOC:go_curators + @@ -54516,8 +80748,15 @@ + Any process that activates or increases the frequency, rate or extent of cell adhesion. positive regulation of cell adhesion + + + + Any process that activates or increases the frequency, rate or extent of cell adhesion. + GOC:go_curators + @@ -54543,8 +80782,17 @@ + Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. negative regulation of cell cycle + + + + Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. + GOC:dph + GOC:go_curators + GOC:tb + @@ -54570,8 +80818,15 @@ + Any process that activates or increases the rate or extent of progression through the cell cycle. positive regulation of cell cycle + + + + Any process that activates or increases the rate or extent of progression through the cell cycle. + GOC:go_curators + @@ -54598,8 +80853,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. negative regulation of endocytosis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. + GOC:go_curators + @@ -54626,8 +80888,85 @@ + Any process that activates or increases the frequency, rate or extent of endocytosis. positive regulation of endocytosis + + + + Any process that activates or increases the frequency, rate or extent of endocytosis. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + negative regulation of glycogen catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + positive regulation of glycogen catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. + GOC:go_curators + @@ -54653,8 +80992,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. negative regulation of heart contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. + GOC:go_curators + @@ -54680,8 +81026,15 @@ + Any process that activates or increases the frequency, rate or extent of heart contraction. positive regulation of heart contraction + + + + Any process that activates or increases the frequency, rate or extent of heart contraction. + GOC:go_curators + @@ -54707,8 +81060,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. negative regulation of lipid metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators + @@ -54734,8 +81094,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. positive regulation of lipid metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. + GOC:go_curators + @@ -54763,8 +81130,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. negative regulation of meiotic nuclear division + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. + GOC:go_curators + @@ -54792,8 +81166,15 @@ + Any process that activates or increases the frequency, rate or extent of meiosis. positive regulation of meiotic nuclear division + + + + Any process that activates or increases the frequency, rate or extent of meiosis. + GOC:go_curators + @@ -54821,8 +81202,17 @@ + Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. negative regulation of mitotic nuclear division + + + + Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. + GOC:dph + GOC:go_curators + GOC:tb + @@ -54849,8 +81239,15 @@ + Any process that activates or increases the frequency, rate or extent of mitosis. positive regulation of mitotic nuclear division + + + + Any process that activates or increases the frequency, rate or extent of mitosis. + GOC:go_curators + @@ -54877,8 +81274,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development. negative regulation of striated muscle tissue development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development. + GOC:go_curators + @@ -54905,8 +81309,15 @@ + Any process that activates or increases the frequency, rate or extent of striated muscle development. positive regulation of striated muscle tissue development + + + + Any process that activates or increases the frequency, rate or extent of striated muscle development. + GOC:go_curators + @@ -54932,8 +81343,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. negative regulation of translational elongation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. + GOC:go_curators + @@ -54959,8 +81377,15 @@ + Any process that activates or increases the frequency, rate or extent of translational elongation. positive regulation of translational elongation + + + + Any process that activates or increases the frequency, rate or extent of translational elongation. + GOC:go_curators + @@ -54987,8 +81412,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination. negative regulation of translational termination + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination. + GOC:go_curators + @@ -55015,8 +81447,15 @@ + Any process that activates or increases the frequency, rate or extent of translational termination. positive regulation of translational termination + + + + Any process that activates or increases the frequency, rate or extent of translational termination. + GOC:go_curators + @@ -55042,8 +81481,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. negative regulation of carbohydrate metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + GOC:go_curators + @@ -55069,8 +81515,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. positive regulation of carbohydrate metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. + GOC:go_curators + @@ -55096,8 +81549,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. negative regulation of catecholamine metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. + GOC:go_curators + @@ -55123,8 +81583,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. positive regulation of catecholamine metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. + GOC:go_curators + @@ -55150,8 +81617,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. negative regulation of exocytosis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. + GOC:go_curators + @@ -55177,8 +81651,15 @@ + Any process that activates or increases the frequency, rate or extent of exocytosis. positive regulation of exocytosis + + + + Any process that activates or increases the frequency, rate or extent of exocytosis. + GOC:go_curators + @@ -55204,8 +81685,15 @@ + Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. negative regulation of growth + + + + Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. + GOC:go_curators + @@ -55231,8 +81719,15 @@ + Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. positive regulation of growth + + + + Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. + GOC:go_curators + @@ -55258,8 +81753,17 @@ + Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. negative regulation of mitotic cell cycle + + + + Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. + GOC:dph + GOC:go_curators + GOC:tb + @@ -55285,8 +81789,17 @@ + Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. positive regulation of mitotic cell cycle + + + + Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. + GOC:dph + GOC:go_curators + GOC:tb + @@ -55312,8 +81825,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. negative regulation of muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. + GOC:go_curators + @@ -55339,8 +81859,15 @@ + Any process that activates or increases the frequency, rate or extent of muscle contraction. positive regulation of muscle contraction + + + + Any process that activates or increases the frequency, rate or extent of muscle contraction. + GOC:go_curators + @@ -55366,8 +81893,15 @@ + Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. negative regulation of nucleobase-containing compound metabolic process + + + + Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:go_curators + @@ -55393,8 +81927,83 @@ + Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. positive regulation of nucleobase-containing compound metabolic process + + + + Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. + negative regulation of steroid metabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. + positive regulation of steroid metabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. + GOC:go_curators + @@ -55420,8 +82029,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. negative regulation of translational initiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. + GOC:go_curators + @@ -55447,8 +82063,15 @@ + Any process that activates or increases the frequency, rate or extent of translational initiation. positive regulation of translational initiation + + + + Any process that activates or increases the frequency, rate or extent of translational initiation. + GOC:go_curators + @@ -55474,8 +82097,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. negative regulation of smooth muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators + @@ -55501,8 +82131,15 @@ + Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. positive regulation of smooth muscle contraction + + + + Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. + GOC:go_curators + @@ -55528,8 +82165,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. negative regulation of striated muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. + GOC:go_curators + @@ -55555,8 +82199,15 @@ + Any process that activates or increases the frequency, rate or extent of striated muscle contraction. positive regulation of striated muscle contraction + + + + Any process that activates or increases the frequency, rate or extent of striated muscle contraction. + GOC:go_curators + @@ -55583,8 +82234,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. negative regulation of embryonic development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. + GOC:go_curators + @@ -55609,8 +82267,15 @@ + Any process that modulates the frequency, rate or extent of embryonic development. regulation of embryonic development + + + + Any process that modulates the frequency, rate or extent of embryonic development. + GOC:go_curators + @@ -55635,8 +82300,15 @@ + Any process that modulates the frequency, rate or extent of resting T cell proliferation. regulation of T cell homeostatic proliferation + + + + Any process that modulates the frequency, rate or extent of resting T cell proliferation. + GOC:go_curators + @@ -55662,8 +82334,15 @@ + Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation. negative regulation of T cell homeostatic proliferation + + + + Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation. + GOC:go_curators + @@ -55688,8 +82367,82 @@ + The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. phenol-containing compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + carboxylic acid biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + ISBN:0198506732 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + carboxylic acid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. + ISBN:0198506732 + @@ -55714,8 +82467,16 @@ + The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. photoreceptor cell differentiation + + + + The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. + GOC:ai + ISBN:0198506732 + @@ -55740,8 +82501,15 @@ + Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. regulation of photoreceptor cell differentiation + + + + Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. + GOC:go_curators + @@ -55768,8 +82536,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. negative regulation of photoreceptor cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. + GOC:go_curators + @@ -55796,8 +82571,15 @@ + Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. positive regulation of photoreceptor cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. + GOC:go_curators + @@ -55811,8 +82593,15 @@ + The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. development of primary female sexual characteristics + + + + The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. + GOC:ai + @@ -55843,8 +82632,15 @@ + Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. retinal rod cell development + + + + Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. + ISBN:0198506732 + @@ -55875,8 +82671,15 @@ + Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. retinal cone cell development + + + + Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. + ISBN:0198506732 + @@ -55902,8 +82705,16 @@ + Any process that modulates the frequency, rate or extent of growth of an organ of an organism. regulation of organ growth + + + + Any process that modulates the frequency, rate or extent of growth of an organ of an organism. + GOC:bf + GOC:tb + @@ -55930,8 +82741,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. negative regulation of organ growth + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. + GOC:bf + GOC:tb + @@ -55958,8 +82777,16 @@ + Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. positive regulation of organ growth + + + + Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. + GOC:bf + GOC:tb + @@ -55984,8 +82811,16 @@ + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. lymphocyte activation + + + + A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. + GOC:mgi_curators + ISBN:0781735149 + @@ -56011,8 +82846,15 @@ + The expansion of a lymphocyte population by cell division. lymphocyte proliferation + + + + The expansion of a lymphocyte population by cell division. + GOC:ai + @@ -56026,8 +82868,15 @@ + The establishment of the sex of a female organism by physical differentiation. female sex differentiation + + + + The establishment of the sex of a female organism by physical differentiation. + GOC:bf + @@ -56041,8 +82890,15 @@ + Programmed cell death that occurs in the developing retina. retinal cell programmed cell death + + + + Programmed cell death that occurs in the developing retina. + GOC:bf + @@ -56073,8 +82929,15 @@ + Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium. compound eye retinal cell programmed cell death + + + + Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium. + PMID:12006672 + @@ -56100,8 +82963,16 @@ + Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina. regulation of retinal cell programmed cell death + + + + Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina. + GOC:ai + GOC:tb + @@ -56126,8 +82997,15 @@ + Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. regulation of compound eye retinal cell programmed cell death + + + + Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. + GOC:ai + @@ -56154,8 +83032,16 @@ + Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina. positive regulation of retinal cell programmed cell death + + + + Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina. + GOC:ai + GOC:tb + @@ -56182,8 +83068,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina. negative regulation of retinal cell programmed cell death + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina. + GOC:ai + GOC:tb + @@ -56209,8 +83103,15 @@ + Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. positive regulation of compound eye retinal cell programmed cell death + + + + Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. + GOC:ai + @@ -56236,8 +83137,50 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. negative regulation of compound eye retinal cell programmed cell death + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. + negative regulation of insulin secretion + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. + GOC:ai + @@ -56288,8 +83231,17 @@ + The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. muscle cell cellular homeostasis + + + + The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. + GOC:mah + PMID:3091429 + PMID:7781901 + @@ -56297,8 +83249,15 @@ + The controlled release of acid by a cell or a tissue. acid secretion + + + + The controlled release of acid by a cell or a tissue. + GOC:ai + @@ -56330,8 +83289,16 @@ + The addition of tubulin heterodimers to one or both ends of a microtubule. microtubule polymerization + + + + The addition of tubulin heterodimers to one or both ends of a microtubule. + GOC:ai + GOC:go_curators + @@ -56339,8 +83306,16 @@ + The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. + Wikipedia:Bone_remodeling bone remodeling + + + + The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. + GOC:curators + @@ -56383,8 +83358,15 @@ + Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. regulation of bone remodeling + + + + Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. + GOC:ai + @@ -56410,8 +83392,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. negative regulation of bone remodeling + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. + GOC:ai + @@ -56437,8 +83426,15 @@ + Any process that activates or increases the frequency, rate or extent of bone remodeling. positive regulation of bone remodeling + + + + Any process that activates or increases the frequency, rate or extent of bone remodeling. + GOC:ai + @@ -56447,8 +83443,15 @@ + The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. hormone secretion + + + + The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. + ISBN:0198506732 + @@ -56476,8 +83479,15 @@ + Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. regulation of hormone secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai + @@ -56505,8 +83515,15 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. positive regulation of hormone secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai + @@ -56534,8 +83551,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. negative regulation of hormone secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. + GOC:ai + @@ -56562,8 +83586,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. positive regulation of lipid biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai + @@ -56589,8 +83620,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. regulation of lipid biosynthetic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai + @@ -56598,8 +83636,15 @@ + The controlled release of a substance by a cell or a tissue. secretion + + + + The controlled release of a substance by a cell or a tissue. + GOC:ai + @@ -56626,8 +83671,94 @@ + The directed movement of substances within a cell. intracellular transport + + + + The directed movement of substances within a cell. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + carboxylic acid transport + + + + + The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + Reactome:R-HSA-390347 + carboxylic acid transmembrane transporter activity + + + + + Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). + GOC:ai + + + + + Reactome:R-HSA-390347 + Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane + @@ -56651,8 +83782,16 @@ + The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. vesicle transport along microtubule + + + + The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. + GOC:ecd + GOC:rl + @@ -56661,8 +83800,15 @@ + The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. embryonic eye morphogenesis + + + + The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. + GOC:jid + @@ -56670,8 +83816,15 @@ + The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. developmental pigmentation + + + + The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. + ISBN:0582227089 + @@ -56696,8 +83849,17 @@ + Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. regulation of developmental pigmentation + + + + Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. + GOC:dph + GOC:jid + GOC:tb + @@ -56723,8 +83885,17 @@ + Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. negative regulation of developmental pigmentation + + + + Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. + GOC:dph + GOC:jid + GOC:tb + @@ -56750,8 +83921,17 @@ + Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. positive regulation of developmental pigmentation + + + + Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. + GOC:dph + GOC:jid + GOC:tb + @@ -56776,8 +83956,16 @@ + The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. somatic stem cell division + + + + The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. + GOC:jid + ISBN:0582227089 + @@ -56820,8 +84008,16 @@ + The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. female germ-line stem cell asymmetric division + + + + The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. + GOC:jid + GOC:mtg_sensu + @@ -56846,8 +84042,15 @@ + The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. fibroblast proliferation + + + + The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. + GOC:jid + @@ -56872,8 +84075,15 @@ + Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. regulation of fibroblast proliferation + + + + Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. + GOC:jid + @@ -56899,8 +84109,15 @@ + Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. positive regulation of fibroblast proliferation + + + + Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. + GOC:jid + @@ -56926,8 +84143,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. negative regulation of fibroblast proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. + GOC:jid + @@ -56952,8 +84176,17 @@ + The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. Golgi vesicle transport + + + + The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. + GOC:jid + ISBN:0716731363 + PMID:10219233 + @@ -56994,8 +84227,17 @@ + The evagination of the Golgi membrane, resulting in formation of a vesicle. Golgi vesicle budding + + + + The evagination of the Golgi membrane, resulting in formation of a vesicle. + GOC:jid + ISBN:0716731363 + PMID:10219233 + @@ -57036,8 +84278,18 @@ + The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. vesicle targeting, to, from or within Golgi + + + + The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. + GOC:jid + GOC:mah + ISBN:0716731363 + PMID:10219233 + @@ -57062,8 +84314,18 @@ + Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus. regulation of vesicle targeting, to, from or within Golgi + + + + Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus. + GOC:jid + GOC:mah + ISBN:0716731363 + PMID:10219233 + @@ -57084,8 +84346,16 @@ + The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. norepinephrine secretion + + + + The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. + GOC:ef + GOC:jid + @@ -57105,8 +84375,15 @@ + The movement of a macrophage in response to an external stimulus. macrophage chemotaxis + + + + The movement of a macrophage in response to an external stimulus. + GOC:jid + @@ -57126,8 +84403,17 @@ + The directed movement of a lymphocyte in response to an external stimulus. lymphocyte chemotaxis + + + + The directed movement of a lymphocyte in response to an external stimulus. + GOC:hjd + GOC:jid + PMID:12391252 + @@ -57152,8 +84438,17 @@ + Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. elastic fiber assembly + + + + Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. + GOC:jid + PMID:10841810 + PMID:12615674 + @@ -57195,8 +84490,15 @@ + The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. vesicle fusion with Golgi apparatus + + + + The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. + GOC:jid + @@ -57221,8 +84523,15 @@ + The creation of a single organelle from two or more organelles. organelle fusion + + + + The creation of a single organelle from two or more organelles. + GOC:jid + @@ -57247,8 +84556,15 @@ + The creation of two or more organelles by division of one organelle. organelle fission + + + + The creation of two or more organelles by division of one organelle. + GOC:jid + @@ -57279,8 +84595,16 @@ + The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. lung alveolus development + + + + The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. + GOC:mtg_lung + PMID:9751757 + @@ -57305,8 +84629,15 @@ + The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei. nuclear membrane fusion involved in karyogamy + + + + The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei. + GOC:jid + @@ -57314,8 +84645,15 @@ + The partitioning of organelles between daughter cells at cell division. organelle inheritance + + + + The partitioning of organelles between daughter cells at cell division. + GOC:jid + @@ -57341,8 +84679,16 @@ + The partitioning of Golgi apparatus between daughter cells at cell division. Golgi inheritance + + + + The partitioning of Golgi apparatus between daughter cells at cell division. + GOC:jid + PMID:12851069 + @@ -57367,8 +84713,15 @@ + The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. axial mesoderm development + + + + The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. + GOC:dgh + @@ -57399,8 +84752,15 @@ + The process in which the anatomical structures of the axial mesoderm are generated and organized. axial mesoderm morphogenesis + + + + The process in which the anatomical structures of the axial mesoderm are generated and organized. + GOC:go_curators + @@ -57431,8 +84791,15 @@ + The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. axial mesoderm formation + + + + The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:dgh + @@ -57463,8 +84830,15 @@ + The process in which the anatomical structures of the mesoderm are generated and organized. mesoderm morphogenesis + + + + The process in which the anatomical structures of the mesoderm are generated and organized. + GOC:go_curators + @@ -57495,8 +84869,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. mesodermal cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. + GOC:dgh + @@ -57522,8 +84903,15 @@ + The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. paraxial mesoderm development + + + + The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. + GOC:dgh + @@ -57555,8 +84943,15 @@ + The process in which the anatomical structures of the paraxial mesoderm are generated and organized. paraxial mesoderm morphogenesis + + + + The process in which the anatomical structures of the paraxial mesoderm are generated and organized. + GOC:go_curators + @@ -57587,8 +84982,15 @@ + The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. paraxial mesoderm formation + + + + The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:dgh + @@ -57614,8 +85016,15 @@ + The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. lateral mesoderm development + + + + The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. + GOC:go_curators + @@ -57647,8 +85056,15 @@ + The process in which the anatomical structures of the lateral mesoderm are generated and organized. lateral mesoderm morphogenesis + + + + The process in which the anatomical structures of the lateral mesoderm are generated and organized. + GOC:go_curators + @@ -57679,8 +85095,15 @@ + The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts. lateral mesoderm formation + + + + The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:jid + @@ -57705,8 +85128,15 @@ + The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. intermediate mesoderm development + + + + The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. + GOC:dgh + @@ -57737,8 +85167,15 @@ + The process in which the anatomical structures of the intermediate mesoderm are generated and organized. intermediate mesoderm morphogenesis + + + + The process in which the anatomical structures of the intermediate mesoderm are generated and organized. + GOC:go_curators + @@ -57769,8 +85206,15 @@ + The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts. intermediate mesoderm formation + + + + The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts. + GOC:dgh + @@ -57802,8 +85246,15 @@ + The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place. cell development + + + + The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place. + GOC:go_curators + @@ -57835,8 +85286,15 @@ + The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state. cell maturation + + + + The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state. + GOC:go_curators + @@ -57874,8 +85332,18 @@ + The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. + Wikipedia:Oogenesis oogenesis + + + + The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. + GOC:kmv + GOC:mtg_sensu + GOC:pr + @@ -57906,8 +85374,17 @@ + The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. autonomic nervous system development + + + + The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. + FMA:9905 + GOC:jid + GOC:sr + @@ -57938,8 +85415,17 @@ + The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. sympathetic nervous system development + + + + The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. + FMA:9906 + GOC:jid + GOC:sr + @@ -57948,8 +85434,18 @@ + The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. regulation of timing of cell differentiation + + + + The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. + GOC:bf + GOC:dph + GOC:jid + GOC:tb + @@ -57957,8 +85453,17 @@ + Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + Wikipedia:Organogenesis animal organ development + + + + Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:dph + GOC:jid + @@ -57989,8 +85494,15 @@ + The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. blood vessel morphogenesis + + + + The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. + GOC:jid + @@ -58015,8 +85527,15 @@ + Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. positive regulation of biological process + + + + Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:jid + @@ -58041,8 +85560,85 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. negative regulation of biological process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:jid + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + positive regulation of behavior + + + + + Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:jid + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + negative regulation of behavior + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:jid + GOC:pr + @@ -58068,8 +85664,15 @@ + Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. positive regulation of cellular process + + + + Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:jid + @@ -58095,8 +85698,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. negative regulation of cellular process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:jid + @@ -58110,8 +85720,51 @@ + The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. hematopoietic or lymphoid organ development + + + + The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. + GOC:add + GOC:rl + ISBN:0781735149 + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. + spleen development + + + + + The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. + GOC:add + ISBN:0781735149 + @@ -58143,8 +85796,16 @@ + The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. bone marrow development + + + + The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. + GOC:add + ISBN:0781735149 + @@ -58169,8 +85830,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. response to steroid hormone + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. + GOC:go_curators + @@ -58201,8 +85869,17 @@ + The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. digestive tract morphogenesis + + + + The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. + GOC:dph + GOC:go_curators + PMID:12618131 + @@ -58217,8 +85894,15 @@ + Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. embryonic organ morphogenesis + + + + Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:jid + @@ -58249,8 +85933,15 @@ + The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. digestive tract development + + + + The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. + GOC:go_curators + @@ -58285,8 +85976,15 @@ + Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. embryonic organ development + + + + Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:jid + @@ -58317,8 +86015,15 @@ + The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. notochord morphogenesis + + + + The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. + GOC:jid + @@ -58343,8 +86048,15 @@ + Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. regulation of post-embryonic development + + + + Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid + @@ -58371,8 +86083,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. negative regulation of post-embryonic development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid + @@ -58399,8 +86118,15 @@ + Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. positive regulation of post-embryonic development + + + + Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. + GOC:jid + @@ -58425,8 +86151,16 @@ + Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of response to stimulus + + + + Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid + @@ -58452,8 +86186,16 @@ + Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. positive regulation of response to stimulus + + + + Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid + @@ -58479,8 +86221,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. negative regulation of response to stimulus + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. + GOC:jid + @@ -58495,8 +86245,16 @@ + The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. developmental cell growth + + + + The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. + GOC:go_curators + GOC:isa_complete + @@ -58521,8 +86279,15 @@ + The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. developmental growth + + + + The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. + GOC:go_curators + @@ -58553,8 +86318,16 @@ + The process in which the anatomical structures of the eye are generated and organized. eye morphogenesis + + + + The process in which the anatomical structures of the eye are generated and organized. + GOC:jid + GOC:mtg_sensu + @@ -58585,8 +86358,16 @@ + The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. camera-type eye morphogenesis + + + + The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. + GOC:jid + GOC:mtg_sensu + @@ -58606,8 +86387,16 @@ + The process in which the anatomical structures of the eye are generated and organized during embryonic development. embryonic camera-type eye morphogenesis + + + + The process in which the anatomical structures of the eye are generated and organized during embryonic development. + GOC:jid + GOC:mtg_sensu + @@ -58621,8 +86410,16 @@ + The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. embryonic morphogenesis + + + + The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. + GOC:jid + GOC:mtg_sensu + @@ -58653,8 +86450,15 @@ + The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. oocyte development + + + + The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:go_curators + @@ -58698,8 +86502,15 @@ + The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte. oocyte morphogenesis + + + + The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte. + GOC:go_curators + @@ -58714,8 +86525,17 @@ + The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. reproductive structure development + + + + The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. + GOC:dph + GOC:isa_complete + GOC:jid + @@ -58723,8 +86543,17 @@ + The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. multicellular organismal reproductive process + + + + The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. + GOC:dph + GOC:jid + GOC:tb + @@ -58755,8 +86584,17 @@ + The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. myoblast development + + + + The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:dph + GOC:mtg_muscle + @@ -58787,8 +86625,17 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. myoblast maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:dph + GOC:mtg_muscle + @@ -58819,8 +86666,17 @@ + The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. skeletal muscle tissue growth + + + + The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. + GOC:lm + PMID:15726494 + PMID:15907921 + @@ -58845,8 +86701,17 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle growth. regulation of skeletal muscle tissue growth + + + + Any process that modulates the frequency, rate or extent of skeletal muscle growth. + GOC:lm + PMID:15726494 + PMID:15907921 + @@ -58872,8 +86737,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth. negative regulation of skeletal muscle tissue growth + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth. + GOC:lm + PMID:15726494 + PMID:15907921 + @@ -58900,8 +86774,17 @@ + Any process that activates, maintains or increases the rate of skeletal muscle growth. positive regulation of skeletal muscle tissue growth + + + + Any process that activates, maintains or increases the rate of skeletal muscle growth. + GOC:lm + PMID:15726494 + PMID:15907921 + @@ -58926,8 +86809,15 @@ + Any process that modulates the frequency, rate or extent of muscle development. regulation of muscle organ development + + + + Any process that modulates the frequency, rate or extent of muscle development. + GOC:go_curators + @@ -58954,8 +86844,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. negative regulation of muscle organ development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. + GOC:go_curators + @@ -58982,8 +86879,15 @@ + Any process that activates, maintains or increases the rate of muscle development. positive regulation of muscle organ development + + + + Any process that activates, maintains or increases the rate of muscle development. + GOC:go_curators + @@ -59009,8 +86913,15 @@ + Any process that modulates the frequency, rate or extent of developmental growth. regulation of developmental growth + + + + Any process that modulates the frequency, rate or extent of developmental growth. + GOC:go_curators + @@ -59037,8 +86948,15 @@ + Any process that activates, maintains or increases the rate of developmental growth. positive regulation of developmental growth + + + + Any process that activates, maintains or increases the rate of developmental growth. + GOC:go_curators + @@ -59065,8 +86983,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. negative regulation of developmental growth + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. + GOC:go_curators + @@ -59091,8 +87016,15 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. regulation of skeletal muscle tissue development + + + + Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. + GOC:go_curators + @@ -59118,8 +87050,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. negative regulation of skeletal muscle tissue development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. + GOC:go_curators + @@ -59145,8 +87084,15 @@ + Any process that activates, maintains or increases the rate of skeletal muscle tissue development. positive regulation of skeletal muscle tissue development + + + + Any process that activates, maintains or increases the rate of skeletal muscle tissue development. + GOC:go_curators + @@ -59177,8 +87123,15 @@ + The process in which the anatomical structures of muscle are generated and organized. muscle organ morphogenesis + + + + The process in which the anatomical structures of muscle are generated and organized. + GOC:jid + @@ -59209,8 +87162,16 @@ + The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. animal organ formation + + + + The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. + GOC:dph + GOC:jid + @@ -59224,8 +87185,18 @@ + The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. anatomical structure formation involved in morphogenesis + + + + The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GOC:dph + GOC:jid + GOC:tb + @@ -59250,8 +87221,17 @@ + The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population. smooth muscle cell proliferation + + + + The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population. + CL:0000192 + GOC:ebc + PMID:1840698 + @@ -59276,8 +87256,16 @@ + Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. regulation of smooth muscle cell proliferation + + + + Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. + CL:0000192 + GOC:ebc + @@ -59303,8 +87291,16 @@ + Any process that activates or increases the rate or extent of smooth muscle cell proliferation. positive regulation of smooth muscle cell proliferation + + + + Any process that activates or increases the rate or extent of smooth muscle cell proliferation. + CL:0000192 + GOC:ebc + @@ -59330,8 +87326,16 @@ + Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. negative regulation of smooth muscle cell proliferation + + + + Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. + CL:0000192 + GOC:ebc + @@ -59362,8 +87366,15 @@ + The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. neuron development + + + + The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + GOC:dph + @@ -59388,8 +87399,16 @@ + The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. cell morphogenesis involved in neuron differentiation + + + + The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. + GOC:dph + GOC:tb + @@ -59397,8 +87416,15 @@ + The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. generation of neurons + + + + The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. + GOC:nln + @@ -59429,8 +87455,18 @@ + The process in which the anatomical structures of the skeleton are generated and organized. skeletal system morphogenesis + + + + The process in which the anatomical structures of the skeleton are generated and organized. + GOC:dph + GOC:dsf + GOC:jid + GOC:tb + @@ -59461,8 +87497,16 @@ + The process in which the anatomical structures of a tissue are generated and organized. tissue morphogenesis + + + + The process in which the anatomical structures of a tissue are generated and organized. + GOC:dph + GOC:jid + @@ -59493,8 +87537,16 @@ + The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. epidermis morphogenesis + + + + The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. + GOC:jid + UBERON:0001003 + @@ -59525,8 +87577,16 @@ + The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. system development + + + + The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. + GOC:dph + GOC:jid + @@ -59551,8 +87611,15 @@ + The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. gland development + + + + The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. + GOC:jid + @@ -59583,8 +87650,16 @@ + The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. appendage development + + + + The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. + GOC:jid + GOC:rc + @@ -59615,8 +87690,17 @@ + The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. cardiac muscle tissue development + + + + The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. + GOC:dph + GOC:jid + GOC:lm + @@ -59647,8 +87731,19 @@ + The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. skeletal muscle fiber development + + + + The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. + GOC:dph + GOC:ef + GOC:jid + GOC:lm + GOC:mtg_muscle + @@ -59674,8 +87769,18 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. regulation of skeletal muscle fiber development + + + + Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. + GOC:dph + GOC:jid + GOC:mtg_muscle + GOC:sm + @@ -59703,8 +87808,18 @@ + Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. positive regulation of skeletal muscle fiber development + + + + Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. + GOC:dph + GOC:jid + GOC:lm + GOC:mtg_muscle + @@ -59731,8 +87846,18 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. negative regulation of skeletal muscle fiber development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. + GOC:dph + GOC:jid + GOC:lm + GOC:mtg_muscle + @@ -59757,8 +87882,17 @@ + The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. smooth muscle tissue development + + + + The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. + GOC:dph + GOC:jid + GOC:lm + @@ -59783,8 +87917,17 @@ + The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye. compound eye development + + + + The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye. + GOC:jid + GOC:mtg_sensu + Wikipedia:Eye + @@ -59815,8 +87958,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. pigment granule organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. + GOC:rc + @@ -59842,8 +87992,17 @@ + The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. branching morphogenesis of an epithelial tube + + + + The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. + GOC:dgh + GOC:dph + GOC:jid + @@ -59874,8 +88033,17 @@ + The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). branching morphogenesis of a nerve + + + + The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). + GOC:dgh + GOC:dph + GOC:jid + @@ -59906,8 +88074,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. mesenchymal cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. + GOC:dph + GOC:jid + @@ -59915,8 +88091,16 @@ + A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. pigment granule + + + + A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. + GOC:jid + GOC:mh + @@ -59924,8 +88108,15 @@ + The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. tissue remodeling + + + + The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. + GOC:ebc + @@ -59956,8 +88147,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. animal organ maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. + GOC:curators + @@ -59972,8 +88170,15 @@ + The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. genitalia development + + + + The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. + GOC:jid + @@ -60004,8 +88209,15 @@ + The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. neuron projection morphogenesis + + + + The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. + GOC:mah + @@ -60036,8 +88248,15 @@ + The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. erythrocyte development + + + + The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. + GOC:devbiol + @@ -60068,8 +88287,15 @@ + The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. nucleate erythrocyte development + + + + The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + GOC:devbiol + @@ -60100,8 +88326,16 @@ + The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. artery morphogenesis + + + + The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. + GOC:dsf + PMID:16740480 + @@ -60132,8 +88366,16 @@ + The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. venous blood vessel morphogenesis + + + + The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. + GOC:dsf + PMID:16740480 + @@ -60164,8 +88406,16 @@ + The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). brain morphogenesis + + + + The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). + GOC:dgh + GOC:jid + @@ -60190,8 +88440,15 @@ + The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. anatomical structure development + + + + The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GO_REF:0000021 + @@ -60216,8 +88473,15 @@ + The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. neural nucleus development + + + + The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. + GO_REF:0000021 + @@ -60249,8 +88513,15 @@ + The process in which the anatomical structures of a cell projection are generated and organized. cell projection morphogenesis + + + + The process in which the anatomical structures of a cell projection are generated and organized. + GO_REF:0000021 + @@ -60275,8 +88546,15 @@ + The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. formation of anatomical boundary + + + + The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GO_REF:0000021 + @@ -60327,8 +88605,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + Wikipedia:Stem_cell_differentiation stem cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + CL:0000034 + GOC:isa_complete + @@ -60359,8 +88646,16 @@ + The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. stem cell development + + + + The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. + CL:0000034 + GOC:isa_complete + @@ -60369,8 +88664,15 @@ + A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. cellular developmental process + + + + A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. + GOC:isa_complete + @@ -60404,8 +88706,18 @@ + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. cell motility + + + + Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. + GOC:dgh + GOC:dph + GOC:isa_complete + GOC:mlg + @@ -60414,8 +88726,15 @@ + Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. multicellular organismal-level homeostasis + + + + Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. + GOC:isa_complete + @@ -60423,8 +88742,15 @@ + Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. homeostasis of number of cells + + + + Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. + GOC:isa_complete + @@ -60433,8 +88759,48 @@ + Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. homeostasis of number of cells within a tissue + + + + Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. + GOC:isa_complete + + + + + + + + + + + + + + + + + + + + + + + + + + Any biological process involved in the maintenance of an internal steady state of a chemical. + chemical homeostasis + + + + + Any biological process involved in the maintenance of an internal steady state of a chemical. + GOC:isa_complete + @@ -60459,8 +88825,15 @@ + The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. sensory system development + + + + The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. + GOC:dgh + @@ -60491,8 +88864,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. peripheral nervous system neuron differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. + GOC:dgh + @@ -60523,8 +88903,15 @@ + The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. peripheral nervous system neuron development + + + + The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. + GOC:dgh + @@ -60549,8 +88936,15 @@ + Any process in which a chromosome is transported to, or maintained in, a specific location. chromosome localization + + + + Any process in which a chromosome is transported to, or maintained in, a specific location. + GOC:ai + @@ -60570,8 +88964,16 @@ + The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. catecholamine secretion + + + + The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:ai + GOC:ef + @@ -60597,8 +88999,15 @@ + Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. regulation of catecholamine secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. + GOC:ai + @@ -60624,8 +89033,15 @@ + The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RNA transport + + + + The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -60651,8 +89067,15 @@ + Any process that modulates the frequency, rate or extent of lymphocyte proliferation. regulation of lymphocyte proliferation + + + + Any process that modulates the frequency, rate or extent of lymphocyte proliferation. + GOC:ai + @@ -60679,8 +89102,15 @@ + Any process that activates or increases the rate or extent of lymphocyte proliferation. positive regulation of lymphocyte proliferation + + + + Any process that activates or increases the rate or extent of lymphocyte proliferation. + GOC:ai + @@ -60707,8 +89137,15 @@ + Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. negative regulation of lymphocyte proliferation + + + + Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. + GOC:ai + @@ -60733,8 +89170,15 @@ + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. epithelial cell proliferation + + + + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. + ISBN:0721662544 + @@ -60759,8 +89203,15 @@ + Any process that modulates the frequency, rate or extent of epithelial cell proliferation. regulation of epithelial cell proliferation + + + + Any process that modulates the frequency, rate or extent of epithelial cell proliferation. + GOC:ai + @@ -60786,8 +89237,15 @@ + Any process that activates or increases the rate or extent of epithelial cell proliferation. positive regulation of epithelial cell proliferation + + + + Any process that activates or increases the rate or extent of epithelial cell proliferation. + GOC:ai + @@ -60813,8 +89271,15 @@ + Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. negative regulation of epithelial cell proliferation + + + + Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. + GOC:ai + @@ -60840,8 +89305,15 @@ + Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. regulation of protein secretion + + + + Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai + @@ -60868,8 +89340,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. negative regulation of protein secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai + @@ -60896,8 +89375,15 @@ + Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. positive regulation of protein secretion + + + + Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. + GOC:ai + @@ -60923,8 +89409,15 @@ + Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. regulation of inflammatory response + + + + Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. + GOC:ai + @@ -60951,8 +89444,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. negative regulation of inflammatory response + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. + GOC:ai + @@ -60979,8 +89479,15 @@ + Any process that activates or increases the frequency, rate or extent of the inflammatory response. positive regulation of inflammatory response + + + + Any process that activates or increases the frequency, rate or extent of the inflammatory response. + GOC:ai + @@ -61005,8 +89512,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. regulation of lipoprotein metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. + GOC:ai + @@ -61032,8 +89546,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. positive regulation of lipoprotein metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. + GOC:ai + @@ -61059,8 +89580,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. negative regulation of lipoprotein metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. + GOC:ai + @@ -61111,8 +89639,15 @@ + Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. regulation of phagocytosis + + + + Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. + GOC:ai + @@ -61138,8 +89673,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. negative regulation of phagocytosis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. + GOC:ai + @@ -61165,8 +89707,15 @@ + Any process that activates or increases the frequency, rate or extent of phagocytosis. positive regulation of phagocytosis + + + + Any process that activates or increases the frequency, rate or extent of phagocytosis. + GOC:ai + @@ -61192,8 +89741,15 @@ + Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. regulation of neurogenesis + + + + Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. + GOC:ai + @@ -61220,8 +89776,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. negative regulation of neurogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. + GOC:ai + @@ -61248,8 +89811,15 @@ + Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. positive regulation of neurogenesis + + + + Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. + GOC:ai + @@ -61275,8 +89845,15 @@ + Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. regulation of immune response + + + + Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai + @@ -61303,8 +89880,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. negative regulation of immune response + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai + @@ -61331,8 +89915,15 @@ + Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. positive regulation of immune response + + + + Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. + GOC:ai + @@ -61357,8 +89948,51 @@ + Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. regulation of biological process + + + + Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. + GOC:ai + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the activity of an enzyme. + regulation of catalytic activity + + + + + Any process that modulates the activity of an enzyme. + GOC:ai + GOC:ebc + GOC:vw + @@ -61383,8 +90017,15 @@ + Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). regulation of developmental process + + + + Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:go_curators + @@ -61409,8 +90050,116 @@ + Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. regulation of cellular process + + + + Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + regulation of behavior + + + + + Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. + GOC:go_curators + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the regulated release of insulin. + regulation of insulin secretion + + + + + Any process that modulates the frequency, rate or extent of the regulated release of insulin. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + monoatomic ion homeostasis + + + + + Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. + GOC:ai + @@ -61429,8 +90178,15 @@ + Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). regulation of synapse structure or activity + + + + Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). + GOC:ai + @@ -61455,8 +90211,15 @@ + Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. modulation of chemical synaptic transmission + + + + Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. + GOC:ai + @@ -61483,8 +90246,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. negative regulation of synaptic transmission + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. + GOC:ai + @@ -61511,8 +90281,15 @@ + Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. positive regulation of synaptic transmission + + + + Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. + GOC:ai + @@ -61543,8 +90320,17 @@ + Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). regulation of synapse organization + + + + Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). + GOC:ai + GOC:dph + GOC:tb + @@ -61569,8 +90355,50 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). synapse organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). + GOC:ai + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + regulation of steroid biosynthetic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. + GOC:ai + @@ -61590,8 +90418,15 @@ + Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. defense response to fungus + + + + Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. + GOC:ai + @@ -61616,8 +90451,15 @@ + Any process that modulates the frequency, rate or extent of T cell activation. regulation of T cell activation + + + + Any process that modulates the frequency, rate or extent of T cell activation. + GOC:ai + @@ -61669,8 +90511,15 @@ + Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. regulation of cell activation + + + + Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. + GOC:ai + @@ -61697,8 +90546,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. negative regulation of cell activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. + GOC:ai + @@ -61725,8 +90581,15 @@ + Any process that activates or increases the frequency, rate or extent of activation. positive regulation of cell activation + + + + Any process that activates or increases the frequency, rate or extent of activation. + GOC:ai + @@ -61753,8 +90616,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. negative regulation of T cell activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. + GOC:ai + @@ -61845,8 +90715,15 @@ + Any process that activates or increases the frequency, rate or extent of T cell activation. positive regulation of T cell activation + + + + Any process that activates or increases the frequency, rate or extent of T cell activation. + GOC:ai + @@ -61883,8 +90760,33 @@ + A organ system process carried out by any of the organs or tissues of neurological system. nervous system process + + + + A organ system process carried out by any of the organs or tissues of neurological system. + GOC:ai + GOC:mtg_cardio + + + + + + + + Any process that modulates the levels of body fluids. + regulation of body fluid levels + + + + + Any process that modulates the levels of body fluids. + GOC:ai + GOC:dph + GOC:tb + @@ -61892,8 +90794,17 @@ + Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. multicellular organismal movement + + + + Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. + GOC:dph + GOC:mtg_muscle + GOC:tb + @@ -61902,9 +90813,15 @@ - + The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. musculoskeletal movement + + + + The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. + GOC:dph + @@ -61912,8 +90829,32 @@ + The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. endocrine process + + + + The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. + ISBN:0721662544 + + + + + + + + + The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. + Wikipedia:Cognition + cognition + + + + + The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. + ISBN:0721619908 + @@ -61921,8 +90862,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to stimulus + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. + GOC:ai + GOC:bf + @@ -61960,8 +90910,20 @@ + The movement of a leukocyte within or between different tissues and organs of the body. leukocyte migration + + + + The movement of a leukocyte within or between different tissues and organs of the body. + GOC:add + ISBN:0781735149 + PMID:14680625 + PMID:14708592 + PMID:7507411 + PMID:8600538 + @@ -61969,8 +90931,15 @@ + Any process pertaining to the functions of the nervous and muscular systems of an organism. neuromuscular process + + + + Any process pertaining to the functions of the nervous and muscular systems of an organism. + GOC:ai + @@ -61995,8 +90964,18 @@ + The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. + Wikipedia:Transduction_(physiology) detection of stimulus involved in sensory perception + + + + The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + GOC:dph + @@ -62022,8 +91001,16 @@ + The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. detection of chemical stimulus involved in sensory perception + + + + The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. + GOC:ai + GOC:dos + @@ -62049,8 +91036,16 @@ + The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. detection of light stimulus involved in visual perception + + + + The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. + GOC:ai + GOC:dos + @@ -62076,8 +91071,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. regulation of chemotaxis + + + + Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. + GOC:ai + @@ -62104,8 +91106,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. positive regulation of chemotaxis + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. + GOC:ai + @@ -62132,8 +91141,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. negative regulation of chemotaxis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. + GOC:ai + @@ -62164,8 +91180,16 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. + Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. pigment cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. + GOC:dgh + @@ -62190,8 +91214,15 @@ + Any process that modulates the frequency, rate or extent of pigmented cell differentiation. regulation of pigment cell differentiation + + + + Any process that modulates the frequency, rate or extent of pigmented cell differentiation. + GOC:ai + @@ -62218,8 +91249,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation. negative regulation of pigment cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation. + GOC:ai + @@ -62246,8 +91284,15 @@ + Any process that activates or increases the frequency, rate or extent of pigment cell differentiation. positive regulation of pigment cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of pigment cell differentiation. + GOC:ai + @@ -62255,8 +91300,15 @@ + The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. sensory perception of light stimulus + + + + The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + @@ -62264,8 +91316,15 @@ + The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. sensory perception of mechanical stimulus + + + + The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. + GOC:ai + @@ -62291,8 +91350,16 @@ + The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. detection of light stimulus involved in sensory perception + + + + The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. + GOC:ai + GOC:dos + @@ -62312,8 +91379,15 @@ + The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. detection of chemical stimulus involved in sensory perception of pain + + + + The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. + GOC:ai + @@ -62321,8 +91395,117 @@ + The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). + Wikipedia:Touch sensory perception of touch + + + + The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + regulation of lipid catabolic process + + + + + Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + negative regulation of lipid catabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + positive regulation of lipid catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. + GOC:ai + @@ -62348,8 +91531,15 @@ + The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. actin filament bundle assembly + + + + The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. + GOC:ai + @@ -62374,8 +91564,100 @@ + The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. DNA transport + + + + The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. + Reactome:R-HSA-203906 + RNA transmembrane transporter activity + + + + + Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. + GOC:ai + + + + + Reactome:R-HSA-203906 + Exportin complex translocates pre-miRNA to cytosol + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other. + DNA transmembrane transporter activity + + + + + Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other. + GOC:ai + @@ -62400,8 +91682,15 @@ + Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. regulation of secretion + + + + Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai + @@ -62427,8 +91716,15 @@ + Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. positive regulation of secretion + + + + Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai + @@ -62454,8 +91750,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. negative regulation of secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. + GOC:ai + @@ -62480,8 +91783,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -62507,8 +91817,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -62534,8 +91851,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -62560,8 +91884,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. regulation of DNA metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. + GOC:ai + @@ -62587,8 +91918,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. negative regulation of DNA metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. + GOC:ai + @@ -62614,8 +91952,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. positive regulation of DNA metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. + GOC:ai + @@ -62642,8 +91987,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. negative regulation of lipid biosynthetic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. + GOC:ai + @@ -62663,8 +92015,15 @@ + The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs. meiotic nuclear membrane disassembly + + + + The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs. + GOC:bf + @@ -62695,8 +92054,15 @@ + The controlled breakdown of the nuclear membranes, for example during cellular division. nuclear membrane disassembly + + + + The controlled breakdown of the nuclear membranes, for example during cellular division. + GOC:ai + @@ -62722,8 +92088,15 @@ + Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). negative regulation of developmental process + + + + Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:ai + @@ -62749,8 +92122,15 @@ + Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). positive regulation of developmental process + + + + Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + GOC:ai + @@ -62775,8 +92155,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. regulation of cellular component organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + GOC:ai + @@ -62802,8 +92189,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. negative regulation of cellular component organization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + GOC:ai + @@ -62829,8 +92223,15 @@ + Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. positive regulation of cellular component organization + + + + Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. + GOC:ai + @@ -62855,8 +92256,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. smooth muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. + CL:0000192 + GOC:ai + @@ -62881,8 +92290,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. striated muscle cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. + CL:0000737 + GOC:ai + @@ -62907,8 +92324,16 @@ + Any process that modulates the frequency, rate or extent of muscle cell differentiation. regulation of muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of muscle cell differentiation. + CL:0000187 + GOC:ai + @@ -62934,8 +92359,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. negative regulation of muscle cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. + CL:0000187 + GOC:ai + @@ -62961,8 +92394,16 @@ + Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. positive regulation of muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. + CL:0000187 + GOC:ai + @@ -62987,8 +92428,16 @@ + Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. regulation of smooth muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. + CL:0000192 + GOC:ai + @@ -63014,8 +92463,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation. negative regulation of smooth muscle cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation. + CL:0000192 + GOC:ai + @@ -63041,8 +92498,16 @@ + Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. positive regulation of smooth muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. + CL:0000192 + GOC:ai + @@ -63067,8 +92532,16 @@ + Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. regulation of striated muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. + CL:0000737 + GOC:ai + @@ -63094,8 +92567,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. negative regulation of striated muscle cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. + CL:0000737 + GOC:ai + @@ -63121,8 +92602,16 @@ + Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. positive regulation of striated muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. + CL:0000737 + GOC:ai + @@ -63151,8 +92640,16 @@ + The directed movement of substances into, out of, or within the nucleus. + Wikipedia:Nuclear_transport nuclear transport + + + + The directed movement of substances into, out of, or within the nucleus. + GOC:ai + @@ -63160,8 +92657,16 @@ + Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. localization + + + + Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. + GOC:ai + GOC:dos + @@ -63198,8 +92703,17 @@ + The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + Wikipedia:Chondrogenesis cartilage development + + + + The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:cjm + PMID:23251424 + @@ -63226,8 +92740,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of protein transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -63253,8 +92774,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of protein transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -63281,8 +92809,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of protein transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -63290,8 +92825,16 @@ + Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. establishment of localization + + + + Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. + GOC:ai + GOC:dos + @@ -63305,8 +92848,15 @@ + The directed movement of RNA to a specific location. establishment of RNA localization + + + + The directed movement of RNA to a specific location. + GOC:ai + @@ -63331,8 +92881,17 @@ + Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. regulation of multicellular organismal process + + + + Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai + GOC:dph + GOC:tb + @@ -63358,8 +92917,15 @@ + Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. positive regulation of multicellular organismal process + + + + Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai + @@ -63385,8 +92951,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. negative regulation of multicellular organismal process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. + GOC:ai + @@ -63411,8 +92984,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. regulation of protein metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. + GOC:ai + @@ -63438,8 +93018,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. positive regulation of protein metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. + GOC:ai + @@ -63465,8 +93052,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. negative regulation of protein metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. + GOC:ai + @@ -63491,8 +93085,15 @@ + Any process that modulates the frequency, rate or extent of lymphocyte activation. regulation of lymphocyte activation + + + + Any process that modulates the frequency, rate or extent of lymphocyte activation. + GOC:ai + @@ -63518,8 +93119,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. negative regulation of lymphocyte activation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. + GOC:ai + @@ -63545,8 +93153,15 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte activation. positive regulation of lymphocyte activation + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte activation. + GOC:ai + @@ -63571,8 +93186,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. regulation of RNA metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. + GOC:ai + @@ -63598,8 +93220,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. negative regulation of RNA metabolic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. + GOC:ai + @@ -63625,8 +93254,15 @@ + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. positive regulation of RNA metabolic process + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. + GOC:ai + @@ -63634,8 +93270,15 @@ + The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. protein polymerization + + + + The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. + GOC:ai + @@ -63643,8 +93286,15 @@ + The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. protein depolymerization + + + + The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. + GOC:ai + @@ -63669,8 +93319,18 @@ + A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. chromosome organization + + + + A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. + GOC:ai + GOC:dph + GOC:jl + GOC:mah + @@ -63678,8 +93338,19 @@ + The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. + Wikipedia:Cell_division + Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. cell division + + + + The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. + GOC:di + GOC:go_curators + GOC:pr + @@ -63704,8 +93375,15 @@ + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. regulation of cell division + + + + Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. + GOC:go_curators + @@ -63726,8 +93404,15 @@ + The directed movement of a chromosome to a specific location. establishment of chromosome localization + + + + The directed movement of a chromosome to a specific location. + GOC:ai + @@ -63771,8 +93456,118 @@ + Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. + Wikipedia:Meiosis + Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. meiotic cell cycle + + + + Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. + regulation of hydrolase activity + + + + + Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. + positive regulation of hydrolase activity + + + + + Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. + GOC:ai + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. + negative regulation of hydrolase activity + + + + + Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. + GOC:ai + @@ -63797,8 +93592,55 @@ + Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. neuron apoptotic process + + + + Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. + CL:0000540 + GOC:mtg_apoptosis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. + detoxification of nitrogen compound + + + + + Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. + GOC:ai + @@ -63824,8 +93666,17 @@ + Any process that modulates the rate or extent of progression through the meiotic cell cycle. regulation of meiotic cell cycle + + + + Any process that modulates the rate or extent of progression through the meiotic cell cycle. + GOC:ai + GOC:dph + GOC:tb + @@ -63852,8 +93703,17 @@ + Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. positive regulation of meiotic cell cycle + + + + Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. + GOC:ai + GOC:dph + GOC:tb + @@ -63880,8 +93740,17 @@ + Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. negative regulation of meiotic cell cycle + + + + Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. + GOC:ai + GOC:dph + GOC:tb + @@ -63906,8 +93775,17 @@ + The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. myoblast proliferation + + + + The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:ai + GOC:mtg_muscle + @@ -63932,8 +93810,17 @@ + The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. myoblast migration + + + + The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. + CL:0000056 + GOC:ai + GOC:mtg_muscle + @@ -63963,8 +93850,15 @@ + The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. vesicle fusion with vacuole + + + + The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. + GOC:ai + @@ -63989,8 +93883,15 @@ + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. regulation of cytoskeleton organization + + + + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. + GOC:ai + @@ -64016,8 +93917,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. negative regulation of cytoskeleton organization + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. + GOC:ai + @@ -64043,8 +93951,15 @@ + Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. positive regulation of cytoskeleton organization + + + + Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. + GOC:ai + @@ -64052,8 +93967,18 @@ + The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. detection of stimulus + + + + The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. + GOC:add + GOC:ai + GOC:dph + GOC:mah + @@ -64081,8 +94006,15 @@ + The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. norepinephrine uptake + + + + The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. + GOC:ai + @@ -64107,8 +94039,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. regulation of norepinephrine uptake + + + + Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. + GOC:ai + @@ -64134,8 +94073,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. negative regulation of norepinephrine uptake + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. + GOC:ai + @@ -64161,8 +94107,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell. positive regulation of norepinephrine uptake + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell. + GOC:ai + @@ -64199,8 +94152,15 @@ + Any process in which an organelle is transported to, and/or maintained in, a specific location. organelle localization + + + + Any process in which an organelle is transported to, and/or maintained in, a specific location. + GOC:ai + @@ -64209,8 +94169,17 @@ + A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular localization + + + + A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. + GOC:tb + GOC:vw + @@ -64235,8 +94204,15 @@ + Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. Golgi localization + + + + Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. + GOC:ai + @@ -64261,8 +94237,15 @@ + Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. nucleus localization + + + + Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. + GOC:ai + @@ -64287,8 +94270,15 @@ + Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. vesicle localization + + + + Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. + GOC:ai + @@ -64331,8 +94321,18 @@ + Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. establishment of localization in cell + + + + Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. + GOC:ai + GOC:dos + GOC:dph + GOC:tb + @@ -64353,8 +94353,15 @@ + The directed movement of a vesicle to a specific location. establishment of vesicle localization + + + + The directed movement of a vesicle to a specific location. + GOC:ai + @@ -64374,8 +94381,15 @@ + The directed movement of an organelle to a specific location. establishment of organelle localization + + + + The directed movement of an organelle to a specific location. + GOC:ai + @@ -64400,8 +94414,15 @@ + Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. localization within membrane + + + + Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. + GOC:ai + @@ -64427,8 +94448,15 @@ + Any process in which a cell is transported to, and/or maintained in, a specific location. localization of cell + + + + Any process in which a cell is transported to, and/or maintained in, a specific location. + GOC:ai + @@ -64449,8 +94477,15 @@ + The directed movement of the Golgi to a specific location. establishment of Golgi localization + + + + The directed movement of the Golgi to a specific location. + GOC:ai + @@ -64459,8 +94494,15 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. response to other organism + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. + GOC:ai + @@ -64469,8 +94511,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular response to stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. + GOC:bf + GOC:jl + @@ -64495,8 +94546,17 @@ + Any process that modulates the rate or extent of progression through the cell cycle. regulation of cell cycle + + + + Any process that modulates the rate or extent of progression through the cell cycle. + GOC:ai + GOC:dph + GOC:tb + @@ -64522,8 +94582,15 @@ + Any process that activates or increases the frequency, rate or extent of cell division. positive regulation of cell division + + + + Any process that activates or increases the frequency, rate or extent of cell division. + GOC:ai + @@ -64549,8 +94616,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. negative regulation of cell division + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. + GOC:ai + @@ -64575,8 +94649,15 @@ + Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. regulation of nuclear division + + + + Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + GOC:ai + @@ -64602,8 +94683,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. negative regulation of nuclear division + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + GOC:ai + @@ -64629,8 +94717,15 @@ + Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. positive regulation of nuclear division + + + + Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. + GOC:ai + @@ -64661,8 +94756,15 @@ + Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. pigment granule localization + + + + Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. + GOC:ai + @@ -64688,8 +94790,15 @@ + Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. regulation of cardioblast differentiation + + + + Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. + GOC:ai + @@ -64716,8 +94825,15 @@ + Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. positive regulation of cardioblast differentiation + + + + Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. + GOC:ai + @@ -64744,8 +94860,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. negative regulation of cardioblast differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. + GOC:ai + @@ -64766,8 +94889,15 @@ + The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. pigment granule transport + + + + The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -64781,8 +94911,15 @@ + The directed movement of a pigment granule to a specific location. establishment of pigment granule localization + + + + The directed movement of a pigment granule to a specific location. + GOC:ai + @@ -64807,8 +94944,15 @@ + Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. regulation of sensory perception of pain + + + + Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. + GOC:ai + @@ -64833,8 +94977,15 @@ + Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. regulation of sensory perception + + + + Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. + GOC:ai + @@ -64859,8 +95010,16 @@ + The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. catecholamine transport + + + + The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. + GOC:ai + ISBN:0198506732 + @@ -64885,8 +95044,15 @@ + Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of amine transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -64912,8 +95078,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. negative regulation of amine transport + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -64939,8 +95112,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. positive regulation of amine transport + + + + Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:ai + @@ -64977,8 +95157,15 @@ + Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. regulation of nervous system development + + + + Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai + @@ -65005,8 +95192,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. negative regulation of nervous system development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai + @@ -65033,8 +95227,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. positive regulation of nervous system development + + + + Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. + GOC:ai + @@ -65059,8 +95260,16 @@ + Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. regulation of synapse assembly + + + + Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. + GOC:ai + GOC:pr + @@ -65087,8 +95296,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. negative regulation of synapse assembly + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. + GOC:ai + GOC:pr + @@ -65115,8 +95332,16 @@ + Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. positive regulation of synapse assembly + + + + Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. + GOC:ai + GOC:pr + @@ -65142,8 +95367,15 @@ + Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. regulation of transmission of nerve impulse + + + + Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. + GOC:ai + @@ -65170,8 +95402,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. negative regulation of transmission of nerve impulse + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. + GOC:ai + @@ -65198,8 +95437,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. positive regulation of transmission of nerve impulse + + + + Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. + GOC:ai + @@ -65224,8 +95470,15 @@ + Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. regulation of chromosome segregation + + + + Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. + GOC:ai + @@ -65251,8 +95504,15 @@ + Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. positive regulation of chromosome segregation + + + + Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. + GOC:ai + @@ -65278,8 +95538,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. negative regulation of chromosome segregation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. + GOC:ai + @@ -65310,8 +95577,16 @@ + The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. muscle cell development + + + + The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. + CL:0000187 + GOC:devbiol + @@ -65342,8 +95617,16 @@ + The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. striated muscle cell development + + + + The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. + CL:0000737 + GOC:devbiol + @@ -65374,8 +95657,15 @@ + The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. cardiac myofibril assembly + + + + The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. + GOC:devbiol + @@ -65406,8 +95696,15 @@ + The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. cardiac cell development + + + + The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. + GOC:devbiol + @@ -65439,8 +95736,16 @@ + The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. cardiac muscle cell differentiation + + + + The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. + GOC:devbiol + GOC:mtg_heart + @@ -65477,8 +95782,15 @@ + The process in which the anatomical structures of cardiac muscle tissue are generated and organized. cardiac muscle tissue morphogenesis + + + + The process in which the anatomical structures of cardiac muscle tissue are generated and organized. + GOC:devbiol + @@ -65515,8 +95827,15 @@ + The process in which the anatomical structure of cardiac atrium muscle is generated and organized. atrial cardiac muscle tissue morphogenesis + + + + The process in which the anatomical structure of cardiac atrium muscle is generated and organized. + GOC:devbiol + @@ -65553,8 +95872,15 @@ + The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. ventricular cardiac muscle tissue morphogenesis + + + + The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. + GOC:devbiol + @@ -65586,8 +95912,16 @@ + The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. cardiac muscle cell development + + + + The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. + GOC:devbiol + GOC:mtg_heart + @@ -65624,8 +95958,15 @@ + The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. cardiac muscle tissue growth + + + + The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. + GOC:devbiol + @@ -65651,8 +95992,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. regulation of cardiac muscle fiber development + + + + Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. + GOC:vk + @@ -65679,8 +96027,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development. negative regulation of cardiac muscle fiber development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development. + GOC:vk + @@ -65707,8 +96062,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development. positive regulation of cardiac muscle fiber development + + + + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development. + GOC:vk + @@ -65733,8 +96095,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle growth. regulation of cardiac muscle tissue growth + + + + Any process that modulates the frequency, rate or extent of cardiac muscle growth. + GOC:vk + @@ -65760,8 +96129,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. negative regulation of cardiac muscle tissue growth + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. + GOC:vk + @@ -65787,8 +96163,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth. positive regulation of cardiac muscle tissue growth + + + + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth. + GOC:vk + @@ -65813,8 +96196,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. regulation of cardiac muscle tissue development + + + + Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. + GOC:vk + @@ -65840,8 +96230,15 @@ + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. positive regulation of cardiac muscle tissue development + + + + Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. + GOC:vk + @@ -65867,8 +96264,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. negative regulation of cardiac muscle tissue development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. + GOC:vk + @@ -65899,8 +96303,16 @@ + The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. neuroblast division + + + + The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. + PMID:11163136 + PMID:11250167 + @@ -65921,8 +96333,44 @@ + The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. asymmetric neuroblast division + + + + The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. + GOC:dph + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell. + intracellular chemical homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell. + GOC:isa_complete + GOC:jid + @@ -65948,8 +96396,51 @@ + The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. + Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. transmembrane transport + + + + The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. + GOC:dph + GOC:jid + + + + + + + + + + + + + + + + + + + + + + + + + + Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. + lipid homeostasis + + + + + Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. + GOC:BHF + GOC:rl + @@ -65974,8 +96465,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. response to lipoprotein particle + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. + GOC:BHF + GOC:rl + @@ -66020,8 +96519,15 @@ + The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex. Golgi to secretory granule transport + + + + The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex. + GOC:curators + @@ -66072,8 +96578,15 @@ + The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Golgi to transport vesicle transport + + + + The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. + GOC:jid + @@ -66099,8 +96612,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle contraction. regulation of cardiac muscle contraction + + + + Any process that modulates the frequency, rate or extent of cardiac muscle contraction. + GOC:ecd + @@ -66127,8 +96647,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. negative regulation of cardiac muscle contraction + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. + GOC:ecd + @@ -66153,8 +96680,49 @@ + The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. digestive system development + + + + The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:jid + + + + + + + + + + + + + + + + + + + + + + + + + + The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. + roof of mouth development + + + + + The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. + GOC:dph + ISBN:0721662544 + @@ -66185,8 +96753,15 @@ + The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. pharyngeal system development + + + + The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. + GOC:dph + @@ -66217,8 +96792,17 @@ + The expansion of a cardiac muscle cell population by cell division. cardiac muscle cell proliferation + + + + The expansion of a cardiac muscle cell population by cell division. + GOC:dph + GOC:rph + PMID:11161571 + @@ -66249,8 +96833,18 @@ + The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. pericardium development + + + + The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. + GOC:dph + GOC:rph + PMID:15138308 + PMID:16376438 + @@ -66285,8 +96879,17 @@ + The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. retina development in camera-type eye + + + + The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + GOC:bf + GOC:dph + ISBN:0815340729 + @@ -66323,8 +96926,17 @@ + The process in which the anatomical structure of the retina is generated and organized. retina morphogenesis in camera-type eye + + + + The process in which the anatomical structure of the retina is generated and organized. + GOC:bf + GOC:dph + GOC:mtg_sensu + @@ -66350,8 +96962,16 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. regulation of cardiac muscle cell proliferation + + + + Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. + GOC:dph + GOC:rph + @@ -66378,8 +96998,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. negative regulation of cardiac muscle cell proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. + GOC:dph + GOC:rph + @@ -66406,8 +97034,16 @@ + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. positive regulation of cardiac muscle cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. + GOC:dph + GOC:rph + @@ -66421,8 +97057,15 @@ + The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. heart contraction + + + + The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. + GOC:dph + @@ -66453,8 +97096,15 @@ + Muscle contraction of cardiac muscle tissue. cardiac muscle contraction + + + + Muscle contraction of cardiac muscle tissue. + GOC:dph + @@ -66489,8 +97139,15 @@ + A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. embryonic process involved in female pregnancy + + + + A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. + GOC:dph + @@ -66516,8 +97173,15 @@ + Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. regulation of syncytium formation by plasma membrane fusion + + + + Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. + GOC:dph + @@ -66544,8 +97208,15 @@ + Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. positive regulation of syncytium formation by plasma membrane fusion + + + + Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. + GOC:dph + @@ -66577,8 +97248,18 @@ + The portion of the plasma membrane surrounding a cilium. + Note that cilia and eukaryotic flagella are deemed to be equivalent. ciliary membrane + + + + The portion of the plasma membrane surrounding a cilium. + GOC:cilia + GOC:dph + GOC:rph + @@ -66603,8 +97284,18 @@ + The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. + Wikipedia:Limb_development limb development + + + + The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. + GOC:dgh + GOC:dph + PMID:11487378 + @@ -66635,8 +97326,17 @@ + Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. endocardium formation + + + + Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:bf + GOC:dph + PMID:17722983 + @@ -66662,8 +97362,19 @@ + The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. hematopoietic stem cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + GOC:BHF + GOC:bf + GOC:dph + GOC:rl + PMID:15378083 + @@ -66700,8 +97411,17 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. camera-type eye photoreceptor cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -66726,8 +97446,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell. retinal rod cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell. + GOC:dph + @@ -66756,8 +97483,17 @@ + A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. mesenchymal to epithelial transition + + + + A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -66765,8 +97501,15 @@ + A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. anatomical structure homeostasis + + + + A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. + GOC:dph + @@ -66791,8 +97534,16 @@ + Any process that modulates the frequency, rate or extent of glial cell proliferation. regulation of glial cell proliferation + + + + Any process that modulates the frequency, rate or extent of glial cell proliferation. + GOC:dph + GOC:tb + @@ -66819,8 +97570,17 @@ + Any process that activates or increases the rate or extent of glial cell proliferation. positive regulation of glial cell proliferation + + + + Any process that activates or increases the rate or extent of glial cell proliferation. + GOC:dph + GOC:sl + GOC:tb + @@ -66847,8 +97607,17 @@ + Any process that stops or decreases the rate or extent of glial cell proliferation. negative regulation of glial cell proliferation + + + + Any process that stops or decreases the rate or extent of glial cell proliferation. + GOC:dph + GOC:sl + GOC:tb + @@ -66873,8 +97642,16 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. regulation of macromolecule metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:dph + GOC:tb + @@ -67104,8 +97881,24 @@ + The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + Note that we deem cilium and microtubule-based flagellum to be equivalent. cilium assembly + + + + The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + GOC:BHF + GOC:cilia + GOC:dph + GOC:kmv + GOC:pr + GOC:vw + ISBN:0198506732 + PMID:13978319 + PMID:27350441 + @@ -67130,8 +97923,17 @@ + Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. regulation of oocyte development + + + + Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:dph + GOC:tb + PMID:2394318 + @@ -67158,8 +97960,16 @@ + Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. positive regulation of oocyte development + + + + Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:dph + GOC:tb + @@ -67186,8 +97996,16 @@ + Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. negative regulation of oocyte development + + + + Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. + GOC:dph + GOC:tb + @@ -67212,8 +98030,16 @@ + Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. regulation of cell development + + + + Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. + GOC:dph + GOC:tb + @@ -67227,8 +98053,21 @@ + Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent. cilium-dependent cell motility + + + + Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. + GOC:cilia + GOC:dgh + GOC:dph + GOC:krc + GOC:mlg + GOC:mtg_cambridge_2013 + @@ -67253,8 +98092,17 @@ + Movement of cilia mediated by motor proteins that contributes to the movement of a cell. cilium movement involved in cell motility + + + + Movement of cilia mediated by motor proteins that contributes to the movement of a cell. + GOC:BHF + GOC:dph + GOC:tb + @@ -67280,8 +98128,17 @@ + Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility. regulation of cilium movement involved in cell motility + + + + Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility. + GOC:BHF + GOC:dph + GOC:tb + @@ -67307,8 +98164,17 @@ + Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. regulation of sarcomere organization + + + + Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + GOC:BHF + GOC:dph + GOC:tb + @@ -67336,8 +98202,17 @@ + Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. positive regulation of sarcomere organization + + + + Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + GOC:BHF + GOC:dph + GOC:tb + @@ -67366,8 +98241,17 @@ + Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. negative regulation of sarcomere organization + + + + Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. + GOC:BHF + GOC:dph + GOC:tb + @@ -67392,8 +98276,15 @@ + The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. head development + + + + The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. + GOC:dph + @@ -67430,8 +98321,15 @@ + The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. head morphogenesis + + + + The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. + GOC:dph + @@ -67462,8 +98360,15 @@ + The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. face development + + + + The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. + GOC:dph + @@ -67500,8 +98405,15 @@ + The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. face morphogenesis + + + + The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. + GOC:dph + @@ -67533,8 +98445,15 @@ + The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). cell chemotaxis + + + + The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). + GOC:dph + @@ -67560,8 +98479,184 @@ + Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. regulation of cellular localization + + + + Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + trabecula formation + + + + + The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod. + liver trabecula formation + + + + + The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod. + spleen trabecula formation + + + + + The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. + heart trabecula formation + + + + + The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. + GOC:dph + @@ -67592,8 +98687,15 @@ + The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. bone development + + + + The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. + GOC:dph + @@ -67630,8 +98732,15 @@ + The process in which bones are generated and organized. bone morphogenesis + + + + The process in which bones are generated and organized. + GOC:dph + @@ -67656,8 +98765,16 @@ + The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. endochondral bone morphogenesis + + + + The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. + GOC:dph + PMID:11680679 + @@ -67682,8 +98799,15 @@ + The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. cartilage development involved in endochondral bone morphogenesis + + + + The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. + GOC:dph + @@ -67708,8 +98832,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. response to ammonium ion + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:23509267 + @@ -67735,8 +98868,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. cardiac muscle cell myoblast differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. + GOC:dph + GOC:tb + @@ -67762,8 +98903,18 @@ + The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules. axonemal microtubule depolymerization + + + + The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules. + GOC:cilia + GOC:dph + GOC:krc + GOC:tb + @@ -67800,8 +98951,16 @@ + The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. cardiac septum morphogenesis + + + + The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. + GOC:dph + GOC:mtg_heart + @@ -67832,8 +98991,15 @@ + The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. ventricular septum morphogenesis + + + + The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. + GOC:dph + @@ -67870,8 +99036,16 @@ + The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. atrial septum morphogenesis + + + + The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. + GOC:dph + GOC:mtg_heart + @@ -67908,8 +99082,18 @@ + The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. aorta smooth muscle tissue morphogenesis + + + + The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. + GOC:bf + GOC:dgh + GOC:dph + Wikipedia:Aorta + @@ -67940,8 +99124,15 @@ + The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. muscle tissue morphogenesis + + + + The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. + GOC:dph + @@ -67972,8 +99163,16 @@ + The increase in size or mass of the heart. heart growth + + + + The increase in size or mass of the heart. + GOC:dph + GOC:tb + @@ -67999,8 +99198,16 @@ + Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. regulation of heart growth + + + + Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. + GOC:dph + GOC:tb + @@ -68026,8 +99233,17 @@ + Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. positive regulation of heart growth + + + + Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. + GOC:BHF + GOC:dph + GOC:tb + @@ -68058,8 +99274,15 @@ + The process in which the anatomical structures of the lung are generated and organized. lung morphogenesis + + + + The process in which the anatomical structures of the lung are generated and organized. + GOC:dph + @@ -68090,8 +99313,16 @@ + The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs. lung vasculature development + + + + The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs. + GOC:dph + GOC:mtg_lung + @@ -68122,8 +99353,16 @@ + The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs. lung connective tissue development + + + + The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs. + GOC:dph + GOC:mtg_lung + @@ -68154,8 +99393,16 @@ + The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. lung epithelium development + + + + The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. + GOC:dph + GOC:mtg_lung + @@ -68180,8 +99427,16 @@ + The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. epithelium development + + + + The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. + GOC:dph + GOC:mtg_lung + @@ -68209,8 +99464,16 @@ + The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds. primary lung bud formation + + + + The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds. + GOC:dph + GOC:mtg_lung + @@ -68241,8 +99504,15 @@ + The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs. bronchus development + + + + The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs. + GOC:dph + @@ -68274,8 +99544,15 @@ + The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs. bronchus morphogenesis + + + + The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs. + GOC:dph + @@ -68306,8 +99583,16 @@ + The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. bronchiole development + + + + The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. + GOC:dph + GOC:mtg_lung + @@ -68338,8 +99623,15 @@ + The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. bronchiole morphogenesis + + + + The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. + GOC:dph + @@ -68370,8 +99662,15 @@ + The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. lung growth + + + + The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. + GOC:dph + @@ -68402,8 +99701,15 @@ + The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. trachea development + + + + The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. + GOC:dph + @@ -68434,8 +99740,15 @@ + The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. trachea morphogenesis + + + + The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. + GOC:dph + @@ -68466,8 +99779,15 @@ + The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches. trachea formation + + + + The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches. + GOC:dph + @@ -68492,8 +99812,88 @@ + The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. epithelial tube branching involved in lung morphogenesis + + + + The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. + GOC:dph + GOC:mtg_lung + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + positive regulation of hindgut contraction + + + + + Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + negative regulation of hindgut contraction + + + + + Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. + GOC:dph + GOC:tb + @@ -68520,8 +99920,16 @@ + Any process that increases the frequency, rate or extent of cardiac muscle contraction. positive regulation of cardiac muscle contraction + + + + Any process that increases the frequency, rate or extent of cardiac muscle contraction. + GOC:dph + GOC:tb + @@ -68547,8 +99955,16 @@ + Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. regulation of gastric acid secretion + + + + Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb + @@ -68575,8 +99991,16 @@ + Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. positive regulation of gastric acid secretion + + + + Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb + @@ -68603,8 +100027,16 @@ + Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. negative regulation of gastric acid secretion + + + + Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. + GOC:dph + GOC:tb + @@ -68630,8 +100062,16 @@ + Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. positive regulation of digestive system process + + + + Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:dph + GOC:tb + @@ -68657,8 +100097,16 @@ + Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. negative regulation of digestive system process + + + + Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. + GOC:dph + GOC:tb + @@ -68683,8 +100131,16 @@ + The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect. right lung development + + + + The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect. + GOC:dph + GOC:mtg_lung + @@ -68709,8 +100165,16 @@ + The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect. left lung development + + + + The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect. + GOC:dph + GOC:mtg_lung + @@ -68741,8 +100205,15 @@ + The process in which anatomical structures of the left lung are generated and organized. left lung morphogenesis + + + + The process in which anatomical structures of the left lung are generated and organized. + GOC:dph + @@ -68773,8 +100244,16 @@ + The process in which anatomical structures of the right lung are generated and organized. right lung morphogenesis + + + + The process in which anatomical structures of the right lung are generated and organized. + GOC:dph + GOC:mtg_lung + @@ -68805,8 +100284,15 @@ + The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung. lung lobe development + + + + The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung. + GOC:dph + @@ -68843,8 +100329,15 @@ + The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung. lung lobe morphogenesis + + + + The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung. + GOC:dph + @@ -68875,8 +100368,15 @@ + The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung. lung lobe formation + + + + The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung. + GOC:dph + @@ -68907,8 +100407,16 @@ + The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth. pharynx development + + + + The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth. + GOC:dph + GOC:rk + @@ -68934,8 +100442,15 @@ + Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). negative regulation of fertilization + + + + Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). + GOC:dph + @@ -68960,8 +100475,15 @@ + The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg. prevention of polyspermy + + + + The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg. + GOC:dph + @@ -68975,8 +100497,16 @@ + The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. lung cell differentiation + + + + The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. + GOC:dph + GOC:mtg_lung + @@ -69007,8 +100537,15 @@ + The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. mesenchyme development + + + + The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. + GOC:dph + @@ -69033,8 +100570,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles. club cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles. + GOC:dph + GOC:mtg_lung + PMID:28144783 + @@ -69066,8 +100612,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. lung epithelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. + GOC:dph + @@ -69093,8 +100646,16 @@ + Any process that modulates the rate, frequency, or extent of cell projection assembly. regulation of cell projection assembly + + + + Any process that modulates the rate, frequency, or extent of cell projection assembly. + GOC:dph + GOC:tb + @@ -69119,8 +100680,16 @@ + Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure. cell-cell signaling involved in lung development + + + + Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure. + GOC:dph + GOC:mtg_lung + @@ -69140,8 +100709,16 @@ + Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung. mesenchymal-epithelial cell signaling involved in lung development + + + + Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung. + GOC:dph + GOC:mtg_lung + @@ -69176,8 +100753,15 @@ + Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell. mesenchymal-endodermal cell signaling + + + + Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell. + GOC:dph + @@ -69203,8 +100787,15 @@ + Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. positive regulation of epithelial cell proliferation involved in lung morphogenesis + + + + Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. + GOC:dph + @@ -69235,8 +100826,15 @@ + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. epithelial cell proliferation involved in lung morphogenesis + + + + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. + GOC:dph + @@ -69261,8 +100859,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles. type I pneumocyte differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles. + GOC:dph + GOC:mtg_lung + ISBN:0721662544 + @@ -69287,8 +100894,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies. type II pneumocyte differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies. + GOC:dph + GOC:mtg_lung + ISBN:0721662544 + @@ -69319,8 +100935,16 @@ + The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. bronchus cartilage development + + + + The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + GOC:mtg_lung + @@ -69357,8 +100981,15 @@ + The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs. bronchus cartilage morphogenesis + + + + The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs. + GOC:dph + @@ -69389,8 +101020,15 @@ + The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. trachea cartilage development + + + + The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + @@ -69427,8 +101065,15 @@ + The process in which the anatomical structures of cartilage in the trachea are generated and organized. trachea cartilage morphogenesis + + + + The process in which the anatomical structures of cartilage in the trachea are generated and organized. + GOC:dph + @@ -69460,8 +101105,15 @@ + The process in which the anatomical structures of cartilage are generated and organized. cartilage morphogenesis + + + + The process in which the anatomical structures of cartilage are generated and organized. + GOC:dph + @@ -69486,8 +101138,15 @@ + The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. muscle tissue development + + + + The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. + GOC:dph + @@ -69512,8 +101171,15 @@ + The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. skeletal muscle organ development + + + + The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. + GOC:dph + @@ -69570,8 +101236,15 @@ + The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs. diaphragm development + + + + The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs. + GOC:dph + @@ -69628,8 +101301,15 @@ + The process in which the anatomical structures of the diaphragm are generated and organized. diaphragm morphogenesis + + + + The process in which the anatomical structures of the diaphragm are generated and organized. + GOC:dph + @@ -69654,8 +101334,15 @@ + The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. respiratory system development + + + + The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. + GOC:dph + @@ -69680,8 +101367,15 @@ + The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. developmental growth involved in morphogenesis + + + + The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. + GOC:dph + @@ -69706,8 +101400,16 @@ + Any apoptotic process that contributes to the shaping of an anatomical structure. apoptotic process involved in morphogenesis + + + + Any apoptotic process that contributes to the shaping of an anatomical structure. + GOC:dph + GOC:mtg_apoptosis + @@ -69733,8 +101435,15 @@ + The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. epithelial tube morphogenesis + + + + The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + GOC:dph + @@ -69759,8 +101468,16 @@ + The process in which epiblast cells acquire specialized features of neuroepithelial cells. neuroepithelial cell differentiation + + + + The process in which epiblast cells acquire specialized features of neuroepithelial cells. + GOC:dph + GOC:tb + @@ -69785,8 +101502,15 @@ + The morphogenetic process in which an epithelial sheet bends along a linear axis. morphogenesis of an epithelial fold + + + + The morphogenetic process in which an epithelial sheet bends along a linear axis. + GOC:dph + @@ -69811,8 +101535,133 @@ + The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding. morphogenesis of an epithelial bud + + + + The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. + intestinal epithelial cell maturation + + + + + The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. + GOC:dph + PMID:18824147 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. + intestinal epithelial cell differentiation + + + + + The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. + intestinal epithelial cell development + + + + + The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. + GOC:dph + @@ -69837,8 +101686,15 @@ + The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart. pulmonary vein morphogenesis + + + + The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart. + GOC:dph + @@ -69863,8 +101719,15 @@ + The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart. superior vena cava morphogenesis + + + + The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart. + GOC:dph + @@ -69889,8 +101752,15 @@ + The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type. cell fate commitment involved in pattern specification + + + + The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type. + GOC:dph + @@ -69921,8 +101791,15 @@ + The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes. chondroblast differentiation + + + + The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes. + GOC:dph + @@ -69953,8 +101830,15 @@ + The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. adipose tissue development + + + + The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. + GOC:dph + @@ -69979,8 +101863,16 @@ + Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. regulation of chromosome condensation + + + + Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. + GOC:dph + GOC:tb + @@ -70006,8 +101898,16 @@ + Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. regulation of vesicle-mediated transport + + + + Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. + GOC:dph + GOC:tb + @@ -70032,8 +101932,16 @@ + Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. regulation of microtubule-based movement + + + + Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. + GOC:dph + GOC:tb + @@ -70068,8 +101976,15 @@ + Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted. mesenchymal-epithelial cell signaling + + + + Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted. + GOC:dph + @@ -70104,8 +102019,15 @@ + Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted. epithelial-mesenchymal cell signaling + + + + Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted. + GOC:dph + @@ -70131,8 +102053,15 @@ + Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. regulation of morphogenesis of a branching structure + + + + Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. + GOC:dph + @@ -70157,8 +102086,15 @@ + Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue. regulation of cell proliferation involved in tissue homeostasis + + + + Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue. + GOC:dph + @@ -70183,8 +102119,15 @@ + Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue. regulation of apoptosis involved in tissue homeostasis + + + + Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue. + GOC:dph + @@ -70209,8 +102152,15 @@ + Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue. regulation of cell differentiation involved in tissue homeostasis + + + + Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue. + GOC:dph + @@ -70241,8 +102191,17 @@ + The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. ectodermal placode formation + + + + The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70267,8 +102226,17 @@ + The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. cell fate commitment involved in formation of primary germ layer + + + + The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70299,8 +102267,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. blood vessel endothelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70325,8 +102302,17 @@ + The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. artery development + + + + The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70351,8 +102337,17 @@ + The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. venous blood vessel development + + + + The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70377,8 +102372,17 @@ + The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries. arterial endothelial cell differentiation + + + + The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70403,8 +102407,17 @@ + The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins. venous endothelial cell differentiation + + + + The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70412,8 +102425,17 @@ + The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate. neural plate pattern specification + + + + The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70422,8 +102444,17 @@ + The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. neural plate regionalization + + + + The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70437,8 +102468,17 @@ + The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. embryonic camera-type eye formation + + + + The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. + GOC:dph + GOC:sdb_2009 + GOC:tb + @@ -70464,8 +102504,16 @@ + Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. positive regulation of macrophage cytokine production + + + + Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. + GOC:dph + GOC:tb + @@ -70496,8 +102544,15 @@ + The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. heart formation + + + + The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. + GOC:mtg_heart + @@ -70522,8 +102577,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. mesenchymal cell differentiation involved in lung development + + + + The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. + GOC:dph + @@ -70548,8 +102610,15 @@ + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. mesenchymal cell proliferation involved in lung development + + + + The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:dph + @@ -70574,8 +102643,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. cardiac pacemaker cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_heart + @@ -70606,8 +102683,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node. sinoatrial node cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node. + GOC:mtg_heart + @@ -70639,8 +102723,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node. atrioventricular node cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node. + GOC:mtg_heart + @@ -70671,8 +102762,16 @@ + The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. cardiac pacemaker cell development + + + + The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. + GOC:mtg_cardiac_conduct_nov11 + GOC:mtg_heart + @@ -70703,8 +102802,15 @@ + The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state. atrioventricular node cell development + + + + The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state. + GOC:mtg_heart + @@ -70735,8 +102841,15 @@ + The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. sinoatrial node cell development + + + + The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. + GOC:mtg_heart + @@ -70767,8 +102880,15 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles. His-Purkinje system cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles. + GOC:mtg_heart + @@ -70799,8 +102919,15 @@ + The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. His-Purkinje system cell development + + + + The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. + GOC:mtg_heart + @@ -70825,8 +102952,15 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. cardiac fibroblast cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. + GOC:mtg_heart + @@ -70857,8 +102991,15 @@ + The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. cardiac fibroblast cell development + + + + The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. + GOC:mtg_heart + @@ -70890,8 +103031,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart. cardiac neuron differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart. + GOC:mtg_heart + @@ -70917,8 +103065,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels. cardiac blood vessel endothelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels. + GOC:mtg_heart + @@ -70944,8 +103099,15 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart. cardiac glial cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart. + GOC:mtg_heart + @@ -70977,8 +103139,15 @@ + The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell. cardiac glial cell development + + + + The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell. + GOC:mtg_heart + @@ -71009,8 +103178,15 @@ + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. endocardial cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:mtg_heart + @@ -71042,8 +103218,15 @@ + The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. endocardial cell development + + + + The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. + GOC:mtg_heart + @@ -71075,8 +103258,15 @@ + The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state. cardiac neuron development + + + + The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state. + GOC:mtg_heart + @@ -71101,8 +103291,15 @@ + The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. cell migration involved in heart development + + + + The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. + GOC:mtg_heart + @@ -71127,8 +103324,15 @@ + The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells. cell migration involved in heart formation + + + + The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells. + GOC:mtg_heart + @@ -71159,8 +103363,15 @@ + The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. coronary vasculature development + + + + The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. + GOC:mtg_heart + @@ -71191,8 +103402,15 @@ + The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. coronary vasculature morphogenesis + + + + The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. + GOC:mtg_heart + @@ -71217,8 +103435,15 @@ + Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels. angiogenesis involved in coronary vascular morphogenesis + + + + Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels. + GOC:mtg_heart + @@ -71243,8 +103468,15 @@ + The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes. vasculogenesis involved in coronary vascular morphogenesis + + + + The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes. + GOC:mtg_heart + @@ -71270,8 +103502,15 @@ + The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart. cell migration involved in coronary vasculogenesis + + + + The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart. + GOC:mtg_heart + @@ -71296,8 +103535,15 @@ + The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels. cell migration involved in coronary angiogenesis + + + + The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels. + GOC:mtg_heart + @@ -71311,8 +103557,217 @@ + The regulated release of a hormone into the circulatory system. endocrine hormone secretion + + + + The regulated release of a hormone into the circulatory system. + GOC:dph + + + + + + + + + An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + hepaticobiliary system process + + + + + An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + hepaticobiliary system development + + + + + The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine. + common bile duct development + + + + + The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine. + PMID:20614624 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile. + gallbladder development + + + + + The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct. + hepatic duct development + + + + + The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct. + GOC:dph + PMID:20614624 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes. + hepatoblast differentiation + + + + + The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes. + GOC:dph + PMID:15226394 + @@ -71337,8 +103792,16 @@ + A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. membrane organization + + + + A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. + GOC:dph + GOC:tb + @@ -71363,8 +103826,17 @@ + The membrane organization process that joins two lipid bilayers to form a single membrane. + Wikipedia:Lipid_bilayer_fusion membrane fusion + + + + The membrane organization process that joins two lipid bilayers to form a single membrane. + GOC:dph + GOC:tb + @@ -71395,8 +103867,16 @@ + The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium. visceral serous pericardium development + + + + The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium. + GOC:dph + GOC:yaf + @@ -71421,8 +103901,15 @@ + Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. regulation of cartilage development + + + + Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + @@ -71449,8 +103936,15 @@ + Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. positive regulation of cartilage development + + + + Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + @@ -71477,8 +103971,15 @@ + Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. negative regulation of cartilage development + + + + Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. + GOC:dph + @@ -71509,8 +104010,16 @@ + The process in which a female gonad is generated and organized. female gonad morphogenesis + + + + The process in which a female gonad is generated and organized. + GOC:BHF + GOC:dph + @@ -71536,8 +104045,16 @@ + Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. regulation of branching involved in lung morphogenesis + + + + Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. + GOC:dph + GOC:yaf + @@ -71564,8 +104081,16 @@ + Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. positive regulation of branching involved in lung morphogenesis + + + + Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. + GOC:dph + GOC:yaf + @@ -71592,8 +104117,16 @@ + Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. negative regulation of branching involved in lung morphogenesis + + + + Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. + GOC:dph + GOC:yaf + @@ -71624,8 +104157,15 @@ + The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. cell growth involved in cardiac muscle cell development + + + + The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. + GOC:dph + @@ -71651,8 +104191,15 @@ + Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. regulation of cell growth involved in cardiac muscle cell development + + + + Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. + GOC:dph + @@ -71681,8 +104228,15 @@ + Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. positive regulation of cell growth involved in cardiac muscle cell development + + + + Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. + GOC:dph + @@ -71711,8 +104265,15 @@ + Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. negative regulation of cell growth involved in cardiac muscle cell development + + + + Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. + GOC:dph + @@ -71743,8 +104304,15 @@ + The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. somite development + + + + The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. + GOC:dph + @@ -71775,8 +104343,15 @@ + The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. dermatome development + + + + The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. + GOC:dph + @@ -71807,8 +104382,15 @@ + The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle. myotome development + + + + The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle. + GOC:dph + @@ -71839,8 +104421,15 @@ + The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. sclerotome development + + + + The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. + GOC:dph + @@ -71877,8 +104466,15 @@ + The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. muscle structure development + + + + The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. + GOC:dph + @@ -71909,8 +104505,15 @@ + The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina. iris morphogenesis + + + + The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina. + GOC:dph + @@ -71941,8 +104544,15 @@ + The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes. ciliary body morphogenesis + + + + The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes. + GOC:dph + @@ -71967,8 +104577,15 @@ + Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. regulation of neural retina development + + + + Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. + GOC:dph + @@ -71994,8 +104611,15 @@ + Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. positive regulation of neural retina development + + + + Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. + GOC:dph + @@ -72021,8 +104645,15 @@ + Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. negative regulation of neural retina development + + + + Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. + GOC:dph + @@ -72053,8 +104684,15 @@ + The progression of the right horn of the sinus venosus from its formation to the mature structure. right horn of sinus venosus development + + + + The progression of the right horn of the sinus venosus from its formation to the mature structure. + GOC:dph + @@ -72079,8 +104717,16 @@ + Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. positive regulation of myeloid leukocyte cytokine production involved in immune response + + + + Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. + GOC:BHF + GOC:dph + @@ -72088,8 +104734,16 @@ + Any process that contributes to cytokine production by a myeloid cell. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. myeloid leukocyte cytokine production + + + + Any process that contributes to cytokine production by a myeloid cell. + GOC:dph + @@ -72115,8 +104769,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. lung neuroendocrine cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. + GOC:dph + PMID:9126746 + @@ -72142,8 +104804,15 @@ + The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. neuroendocrine cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. + GOC:dph + @@ -72175,8 +104844,16 @@ + The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium. stomach neuroendocrine cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium. + GOC:dph + PMID:18173746 + @@ -72202,8 +104879,15 @@ + Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. regulation of stomach neuroendocrine cell differentiation + + + + Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. + GOC:dph + @@ -72230,8 +104914,15 @@ + Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. negative regulation of stomach neuroendocrine cell differentiation + + + + Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. + GOC:dph + @@ -72256,8 +104947,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells. dense core granule organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells. + GOC:dph + @@ -72277,8 +104975,87 @@ + Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ. epithelial-mesenchymal cell signaling involved in lung development + + + + Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized. + pancreas morphogenesis + + + + + Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the branches of the pancreas are generated and organized. + branching involved in pancreas morphogenesis + + + + + The process in which the branches of the pancreas are generated and organized. + GOC:dph + @@ -72304,8 +105081,51 @@ + Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. negative regulation of heart growth + + + + Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. + GOC:dph + GOC:hjd + + + + + + + + + + + + + + + + + + + + + + + + + + + + The morphogenetic process in which the foregut region specified to become the pancreas forms a bud. + pancreatic bud formation + + + + + The morphogenetic process in which the foregut region specified to become the pancreas forms a bud. + GOC:dph + @@ -72314,8 +105134,15 @@ + The process in which the anatomical structures of a branched epithelium are generated and organized. morphogenesis of a branching epithelium + + + + The process in which the anatomical structures of a branched epithelium are generated and organized. + GOC:dph + @@ -72340,8 +105167,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part. lung secretory cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part. + GOC:dph + @@ -72366,8 +105200,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells. lung ciliated cell differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells. + GOC:cilia + GOC:dph + GOC:krc + @@ -72398,8 +105241,15 @@ + The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. endocardial endothelium development + + + + The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:dph + @@ -72424,8 +105274,15 @@ + A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. extracellular matrix organization involved in endocardium development + + + + A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. + GOC:dph + @@ -72456,8 +105313,55 @@ + The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea. trachea submucosa development + + + + The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea. + GOC:dph + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection. + trachea gland development + + + + + The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection. + GOC:dph + @@ -72483,8 +105387,16 @@ + The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. endothelial tube morphogenesis + + + + The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. + GOC:dph + GOC:yaf + @@ -72515,8 +105427,16 @@ + The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery. pulmonary artery endothelial tube morphogenesis + + + + The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery. + GOC:dph + GOC:yaf + @@ -72541,8 +105461,86 @@ + The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs. pulmonary artery morphogenesis + + + + The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs. + GOC:dph + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + regulation of insulin secretion involved in cellular response to glucose stimulus + + + + + Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + GOC:BHF + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + negative regulation of insulin secretion involved in cellular response to glucose stimulus + + + + + Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. + GOC:BHF + GOC:dph + @@ -72568,8 +105566,16 @@ + Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. regulation of chondrocyte development + + + + Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + GOC:BHF + GOC:dph + @@ -72596,8 +105602,16 @@ + Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. negative regulation of chondrocyte development + + + + Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. + GOC:BHF + GOC:dph + @@ -72622,8 +105636,16 @@ + Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. regulation of dermatome development + + + + Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. + GOC:BHF + GOC:dph + @@ -72649,8 +105671,16 @@ + Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. positive regulation of dermatome development + + + + Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. + GOC:BHF + GOC:dph + @@ -72676,8 +105706,16 @@ + Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. negative regulation of dermatome development + + + + Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. + GOC:BHF + GOC:dph + @@ -72703,8 +105741,16 @@ + Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. positive regulation of sclerotome development + + + + Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. + GOC:BHF + GOC:dph + @@ -72729,8 +105775,15 @@ + Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. regulation of sclerotome development + + + + Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. + GOC:dph + @@ -72761,8 +105814,16 @@ + The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. retina vasculature development in camera-type eye + + + + The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. + GOC:BHF + GOC:dph + @@ -72793,8 +105854,16 @@ + The process in which the vasculature of the retina is generated and organized. retina vasculature morphogenesis in camera-type eye + + + + The process in which the vasculature of the retina is generated and organized. + GOC:BHF + GOC:dph + @@ -72825,8 +105894,15 @@ + The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. cornea development in camera-type eye + + + + The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. + GOC:dph + @@ -72852,8 +105928,16 @@ + The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. retinal blood vessel morphogenesis + + + + The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. + GOC:BHF + GOC:dph + @@ -72873,8 +105957,17 @@ + The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches. cardiac neural crest cell differentiation involved in heart development + + + + The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches. + GOC:dph + GOC:mtg_heart + PMID:19705442 + @@ -72899,8 +105992,16 @@ + The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart. cardiac neural crest cell development involved in heart development + + + + The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart. + GOC:dph + GOC:mtg_heart + @@ -72925,8 +106026,16 @@ + The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract. cardiac neural crest cell development involved in outflow tract morphogenesis + + + + The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract. + GOC:dph + GOC:mtg_heart + @@ -72951,8 +106060,16 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart. cell proliferation involved in heart morphogenesis + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart. + GOC:dph + GOC:mtg_heart + @@ -72977,8 +106094,16 @@ + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract. cell proliferation involved in outflow tract morphogenesis + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract. + GOC:dph + GOC:mtg_heart + @@ -72986,8 +106111,15 @@ + Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. cardiac conduction + + + + Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. + GOC:dph + @@ -73012,8 +106144,17 @@ + The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart. cell adhesion involved in heart morphogenesis + + + + The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart. + GOC:dph + GOC:mtg_heart + PMID:16860783 + @@ -73038,8 +106179,17 @@ + Any process that modulates the extent of cell adhesion contributing to the shaping of the heart. regulation of cell adhesion involved in heart morphogenesis + + + + Any process that modulates the extent of cell adhesion contributing to the shaping of the heart. + GOC:dph + GOC:mtg_heart + PMID:16860783 + @@ -73047,8 +106197,82 @@ + The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. neural precursor cell proliferation + + + + The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. + GOC:dph + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + trabecula morphogenesis + + + + + The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + heart trabecula morphogenesis + + + + + The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. + GOC:dph + @@ -73068,8 +106292,15 @@ + The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart. fibroblast proliferation involved in heart morphogenesis + + + + The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart. + GOC:dph + @@ -73094,8 +106325,15 @@ + The progression of a connective tissue over time, from its formation to the mature structure. connective tissue development + + + + The progression of a connective tissue over time, from its formation to the mature structure. + GOC:BHF + @@ -73126,8 +106364,49 @@ + Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst. trophoblast cell migration + + + + Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction. + interstitial cell of Cajal differentiation + + + + + The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction. + GOC:dph + @@ -73152,8 +106431,15 @@ + The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. reproductive system development + + + + The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. + GOC:dph + @@ -73178,8 +106464,48 @@ + A process in which a protein is transported to, or maintained in, a location within a lysosome. protein localization to lysosome + + + + A process in which a protein is transported to, or maintained in, a location within a lysosome. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation. + regulation of type B pancreatic cell proliferation + + + + + Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation. + GOC:dph + @@ -73204,8 +106530,16 @@ + Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. hematopoietic stem cell homeostasis + + + + Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. + GOC:dph + PMID:21508411 + @@ -73398,8 +106732,15 @@ + A process in which a protein is transported to, or maintained in, a location within a cilium. protein localization to cilium + + + + A process in which a protein is transported to, or maintained in, a location within a cilium. + GOC:dph + @@ -73430,8 +106771,15 @@ + The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. myeloid cell development + + + + The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. + GOC:dph + @@ -73457,8 +106805,16 @@ + The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. macrophage homeostasis + + + + The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. + GOC:dph + PMID:21727904 + @@ -73483,8 +106839,52 @@ + A cellular process that results in the breakdown of a cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. cilium disassembly + + + + A cellular process that results in the breakdown of a cilium. + GOC:cilia + GOC:dph + PMID:17604723 + PMID:27350441 + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut. + hindgut development + + + + + The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut. + GOC:dph + @@ -73515,8 +106915,15 @@ + The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. ganglion development + + + + The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. + GOC:dph + @@ -73547,8 +106954,16 @@ + The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. sympathetic ganglion development + + + + The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. + GOC:BHF + GOC:rl + @@ -73579,8 +106994,15 @@ + The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. cranial ganglion development + + + + The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. + GOC:dph + @@ -73605,8 +107027,15 @@ + The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure. trigeminal ganglion development + + + + The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure. + GOC:dph + @@ -73637,8 +107066,15 @@ + The process in which the anatomical structures of ganglion are generated and organized. ganglion morphogenesis + + + + The process in which the anatomical structures of ganglion are generated and organized. + GOC:dph + @@ -73669,8 +107105,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state. ganglion maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state. + GOC:dph + @@ -73701,8 +107144,15 @@ + The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts. ganglion formation + + + + The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts. + GOC:dph + @@ -73739,8 +107189,15 @@ + The process in which the anatomical structure of a trigeminal ganglion is generated and organized. trigeminal ganglion morphogenesis + + + + The process in which the anatomical structure of a trigeminal ganglion is generated and organized. + GOC:dph + @@ -73777,8 +107234,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state. trigeminal ganglion maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state. + GOC:dph + @@ -73815,8 +107279,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state. cranial ganglion maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state. + GOC:dph + @@ -73853,8 +107324,15 @@ + The process in which the anatomical structure of a cranial ganglion is generated and organized. cranial ganglion morphogenesis + + + + The process in which the anatomical structure of a cranial ganglion is generated and organized. + GOC:dph + @@ -73885,8 +107363,15 @@ + The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts. cranial ganglion formation + + + + The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts. + GOC:dph + @@ -73917,8 +107402,15 @@ + The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts. trigeminal ganglion formation + + + + The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts. + GOC:dph + @@ -73943,8 +107435,48 @@ + A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. actin filament bundle organization + + + + A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism. + colon epithelial cell migration + + + + + The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism. + GOC:dph + @@ -73969,8 +107501,48 @@ + The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism. corneal epithelial cell migration + + + + The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism. + GOC:dph + + + + + + + + + + + + + + + + + + + + + + + + + + The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism. + intestinal epithelial cell migration + + + + + The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism. + GOC:dph + @@ -74001,8 +107573,17 @@ + The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. pharyngeal arch artery morphogenesis + + + + The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. + GOC:BHF + GOC:dph + PMID:20122914 + @@ -74028,8 +107609,18 @@ + Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling. secretory granule maturation + + + + Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling. + GOC:PARL + GOC:bf + GOC:dph + PMID:16618809 + @@ -74054,8 +107645,15 @@ + Any process that modulates the frequency, rate or extent of neuroblast migration. regulation of neuroblast migration + + + + Any process that modulates the frequency, rate or extent of neuroblast migration. + PMID:23149556 + @@ -74081,8 +107679,15 @@ + Any process that activates or increases the frequency, rate or extent of neuroblast migration. positive regulation of neuroblast migration + + + + Any process that activates or increases the frequency, rate or extent of neuroblast migration. + PMID:23149556 + @@ -74108,8 +107713,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration. negative regulation of neuroblast migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration. + PMID:23149556 + @@ -74140,8 +107752,17 @@ + A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. glial cell activation + + + + A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. + GOC:aruk + GOC:bc + PMID:18723082 + @@ -74166,8 +107787,15 @@ + A process in which a protein is transported to or maintained in a location within the somatodendritic compartment. protein localization to somatodendritic compartment + + + + A process in which a protein is transported to or maintained in a location within the somatodendritic compartment. + PMID:18341993 + @@ -74191,8 +107819,16 @@ + The directed movement of a protein to a specific location in a plasma membrane. establishment of protein localization to plasma membrane + + + + The directed movement of a protein to a specific location in a plasma membrane. + GOC:dph + GOC:vw + @@ -74217,8 +107853,15 @@ + The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone. replacement bone morphogenesis + + + + The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone. + PMID:29852585 + @@ -74243,8 +107886,16 @@ + The process in which bone which forms superficially in the organism are generated and organized. dermal bone morphogenesis + + + + The process in which bone which forms superficially in the organism are generated and organized. + PMID:12588850 + PMID:15003632 + @@ -74269,8 +107920,116 @@ + The process in which bone which forms deep in the organism are generated and organized. membrane bone morphogenesis + + + + The process in which bone which forms deep in the organism are generated and organized. + PMID:14579374 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the rate, frequency or extent of a small molecule metabolic process. + regulation of small molecule metabolic process + + + + + Any process that modulates the rate, frequency or extent of a small molecule metabolic process. + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. + positive regulation of small molecule metabolic process + + + + + Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. + negative regulation of small molecule metabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. + GOC:vw + @@ -74290,8 +108049,17 @@ + An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. collagen-containing extracellular matrix + + + + An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. + GOC:BHF + GOC:rph + PMID:21123617 + @@ -74318,8 +108086,15 @@ + Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis. positive regulation of mitotic sister chromatid segregation + + + + Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis. + PMID:12773390 + @@ -74350,8 +108125,15 @@ + The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. stomach development + + + + The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. + PMID:11967278 + @@ -74376,8 +108158,15 @@ + The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. detection of stimulus involved in sensory perception of pain + + + + The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. + PMID:19837031 + @@ -74402,8 +108191,15 @@ + Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell. protein localization to postsynapse + + + + Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell. + PMID:31189538 + @@ -74431,8 +108227,16 @@ + The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. + Note that this term is not intended for use in annotating lateral movement within membranes. intracellular protein transmembrane transport + + + + The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. + GOC:isa_complete + @@ -74458,8 +108262,15 @@ + The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. protein-containing complex assembly + + + + The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. + GOC:jl + @@ -74485,8 +108296,15 @@ + The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. protein-DNA complex assembly + + + + The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. + GOC:jl + @@ -74494,8 +108312,52 @@ + Any process that modulates a measurable attribute of any biological process, quality or function. biological regulation + + + + Any process that modulates a measurable attribute of any biological process, quality or function. + GOC:dph + GOC:isa_complete + GOC:mah + GOC:pr + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + regulation of molecular function + + + + + Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. + GOC:isa_complete + @@ -74515,8 +108377,15 @@ + Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. extracellular membrane-bounded organelle + + + + Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. + GOC:isa_complete + @@ -74541,8 +108410,15 @@ + An organelle lumen that is part of an intracellular organelle. intracellular organelle lumen + + + + An organelle lumen that is part of an intracellular organelle. + GOC:mah + @@ -74567,8 +108443,16 @@ + The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. neuron cellular homeostasis + + + + The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. + GOC:BHF + GOC:mah + @@ -74582,8 +108466,23 @@ + A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. extracellular exosome + + + + A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. + GOC:BHF + GOC:mah + GOC:vesicles + PMID:15908444 + PMID:17641064 + PMID:19442504 + PMID:19498381 + PMID:22418571 + PMID:24009894 + @@ -74608,8 +108507,16 @@ + The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). glucagon secretion + + + + The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). + GOC:BHF + GOC:rl + @@ -74634,8 +108541,16 @@ + Any process that modulates the frequency, rate or extent of the regulated release of glucagon. regulation of glucagon secretion + + + + Any process that modulates the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah + @@ -74661,8 +108576,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. negative regulation of glucagon secretion + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah + @@ -74688,8 +108611,16 @@ + Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. positive regulation of glucagon secretion + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. + GOC:BHF + GOC:mah + @@ -74697,8 +108628,15 @@ + A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. anchoring junction + + + + A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. + ISBN:0815332181 + @@ -74718,8 +108656,15 @@ + A process of chromosome organization that is involved in a meiotic cell cycle. chromosome organization involved in meiotic cell cycle + + + + A process of chromosome organization that is involved in a meiotic cell cycle. + GOC:mah + @@ -74739,8 +108684,16 @@ + The directed movement of a protein to a specific location on a chromosome. establishment of protein localization to chromosome + + + + The directed movement of a protein to a specific location on a chromosome. + GOC:BHF + GOC:mah + @@ -74765,8 +108718,16 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. regulation of establishment of protein localization + + + + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. + GOC:BHF + GOC:mah + @@ -74791,8 +108752,16 @@ + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. regulation of establishment of protein localization to chromosome + + + + Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. + GOC:BHF + GOC:mah + @@ -74817,8 +108786,19 @@ + Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). lymphocyte apoptotic process + + + + Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. + CL:0000542 + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74843,8 +108823,18 @@ + Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). regulation of lymphocyte apoptotic process + + + + Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74870,8 +108860,18 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). negative regulation of lymphocyte apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74897,8 +108897,18 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). positive regulation of lymphocyte apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74923,8 +108933,18 @@ + Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. T cell apoptotic process + + + + Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. + CL:0000084 + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74949,8 +108969,17 @@ + Any process that modulates the occurrence or rate of T cell death by apoptotic process. regulation of T cell apoptotic process + + + + Any process that modulates the occurrence or rate of T cell death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -74976,8 +109005,17 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. negative regulation of T cell apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -75003,8 +109041,17 @@ + Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. positive regulation of T cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. + GOC:add + GOC:mtg_apoptosis + ISBN:0781765196 + @@ -75029,8 +109076,156 @@ + The regulated release of somatostatin from secretory granules in the D cells of the pancreas. somatostatin secretion + + + + The regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. + mucus secretion + + + + + The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. + GOC:add + ISBN:068340007X + ISBN:0721662544 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + regulation of mucus secretion + + + + + Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + negative regulation of mucus secretion + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + positive regulation of mucus secretion + + + + + Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. + GOC:add + @@ -75061,8 +109256,15 @@ + The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate. pigment cell development + + + + The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate. + GOC:cvs + @@ -75087,8 +109289,16 @@ + The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. fat cell proliferation + + + + The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. + GOC:mah + GOC:sl + @@ -75113,8 +109323,16 @@ + Any process that modulates the frequency, rate or extent of fat cell proliferation. regulation of fat cell proliferation + + + + Any process that modulates the frequency, rate or extent of fat cell proliferation. + GOC:mah + GOC:sl + @@ -75140,8 +109358,16 @@ + Any process that stops or decreases the rate or extent of fat cell proliferation. negative regulation of fat cell proliferation + + + + Any process that stops or decreases the rate or extent of fat cell proliferation. + GOC:mah + GOC:sl + @@ -75167,8 +109393,162 @@ + Any process that activates or increases the rate or extent of fat cell proliferation. positive regulation of fat cell proliferation + + + + Any process that activates or increases the rate or extent of fat cell proliferation. + GOC:mah + GOC:sl + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. + hepatocyte differentiation + + + + + The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. + CL:0000182 + PMID:7588884 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of hepatocyte differentiation. + regulation of hepatocyte differentiation + + + + + Any process that modulates the frequency, rate or extent of hepatocyte differentiation. + GOC:mah + GOC:sl + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops or decreases the rate or extent of hepatocyte differentiation. + negative regulation of hepatocyte differentiation + + + + + Any process that stops or decreases the rate or extent of hepatocyte differentiation. + GOC:mah + GOC:sl + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the rate or extent of hepatocyte differentiation. + positive regulation of hepatocyte differentiation + + + + + Any process that activates or increases the rate or extent of hepatocyte differentiation. + GOC:mah + GOC:sl + @@ -75188,8 +109568,16 @@ + A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. exocytic vesicle + + + + A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. + GOC:kad + GOC:mah + @@ -75197,8 +109585,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. response to oxygen levels + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. + GOC:BHF + GOC:mah + @@ -75207,8 +109603,16 @@ + The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. detection of hypoxia + + + + The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. + GOC:BHF + GOC:mah + @@ -75234,8 +109638,15 @@ + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. regulation of microtubule cytoskeleton organization + + + + Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. + GOC:mah + @@ -75260,8 +109671,17 @@ + The directed movement of a substance from one side of an epithelium to the other. transepithelial transport + + + + The directed movement of a substance from one side of an epithelium to the other. + GOC:mah + GOC:yaf + ISBN:0716731363 + @@ -75286,8 +109706,16 @@ + The directed movement of ammonium ions from one side of an epithelium to the other. transepithelial ammonium transport + + + + The directed movement of ammonium ions from one side of an epithelium to the other. + GOC:mah + GOC:yaf + @@ -75324,8 +109752,15 @@ + The expansion of a leukocyte population by cell division. leukocyte proliferation + + + + The expansion of a leukocyte population by cell division. + GOC:add + @@ -75350,8 +109785,16 @@ + Any process that modulates the frequency, rate or extent of leukocyte proliferation. regulation of leukocyte proliferation + + + + Any process that modulates the frequency, rate or extent of leukocyte proliferation. + GOC:add + GOC:mah + @@ -75377,8 +109820,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. negative regulation of leukocyte proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. + GOC:add + GOC:mah + @@ -75404,8 +109855,16 @@ + Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. positive regulation of leukocyte proliferation + + + + Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. + GOC:add + GOC:mah + @@ -75414,8 +109873,15 @@ + Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. cellular macromolecule localization + + + + Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. + GOC:mah + @@ -75440,8 +109906,233 @@ + The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. + Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer. basement membrane assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + regulation of bile acid biosynthetic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + negative regulation of bile acid biosynthetic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + positive regulation of bile acid biosynthetic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. + GOC:BHF + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + regulation of glycogen metabolic process + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + negative regulation of glycogen metabolic process + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + positive regulation of glycogen metabolic process + + + + + Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. + GOC:mah + @@ -75450,8 +110141,16 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular response to chemical stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. + GOC:mah + @@ -75476,8 +110175,15 @@ + The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. organelle assembly + + + + The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. + GOC:mah + @@ -75508,8 +110214,16 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. bone maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. + GOC:dph + GOC:mah + @@ -75534,8 +110248,15 @@ + Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. protein localization to chromatin + + + + Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. + GOC:mah + @@ -75555,8 +110276,15 @@ + The directed movement of a protein to a part of a chromosome that is organized into chromatin. establishment of protein localization to chromatin + + + + The directed movement of a protein to a part of a chromosome that is organized into chromatin. + GOC:mah + @@ -75576,8 +110304,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. cellular response to ammonium ion + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:23509267 + @@ -75597,8 +110334,72 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. cellular response to carbohydrate stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. + GOC:mah + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. + cellular response to hexose stimulus + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. + cellular response to glucose stimulus + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. + GOC:mah + @@ -75618,8 +110419,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. cellular response to peptide hormone stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. + GOC:mah + @@ -75639,8 +110447,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. cellular response to glucagon stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. + GOC:mah + @@ -75660,8 +110475,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. cellular response to steroid hormone stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. + GOC:mah + @@ -75681,8 +110503,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. cellular response to lipid + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. + GOC:mah + @@ -75703,8 +110532,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. cellular response to organonitrogen compound + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. + GOC:mah + @@ -75724,8 +110560,15 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. cellular response to amine stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. + GOC:mah + @@ -75756,8 +110599,19 @@ + The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. hematopoietic stem cell proliferation + + + + The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. + CL:0000037 + GOC:BHF + GOC:add + GOC:mah + GOC:rl + @@ -75765,8 +110619,16 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular response to endogenous stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. + GOC:mah + @@ -75786,8 +110648,15 @@ + The movement of a granulocyte in response to an external stimulus. granulocyte chemotaxis + + + + The movement of a granulocyte in response to an external stimulus. + GOC:rph + @@ -75812,8 +110681,15 @@ + Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. regulation of granulocyte chemotaxis + + + + Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. + GOC:mah + @@ -75839,8 +110715,15 @@ + Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. negative regulation of granulocyte chemotaxis + + + + Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. + GOC:mah + @@ -75866,8 +110749,15 @@ + Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. positive regulation of granulocyte chemotaxis + + + + Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. + GOC:mah + @@ -75875,8 +110765,15 @@ + The process of biting and mashing food with the teeth prior to swallowing. mastication + + + + The process of biting and mashing food with the teeth prior to swallowing. + GOC:gvg + @@ -75896,8 +110793,15 @@ + The directed movement of a smooth muscle cell in response to an external stimulus. smooth muscle cell chemotaxis + + + + The directed movement of a smooth muscle cell in response to an external stimulus. + GOC:mah + @@ -75923,8 +110827,15 @@ + Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis. regulation of smooth muscle cell chemotaxis + + + + Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis. + GOC:mah + @@ -75951,8 +110862,15 @@ + Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis. negative regulation of smooth muscle cell chemotaxis + + + + Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis. + GOC:mah + @@ -75979,8 +110897,15 @@ + Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis. positive regulation of smooth muscle cell chemotaxis + + + + Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis. + GOC:mah + @@ -76005,8 +110930,15 @@ + The movement of a mononuclear cell within or between different tissues and organs of the body. mononuclear cell migration + + + + The movement of a mononuclear cell within or between different tissues and organs of the body. + GOC:mah + @@ -76031,8 +110963,15 @@ + Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. regulation of mononuclear cell migration + + + + Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. + GOC:mah + @@ -76058,8 +110997,15 @@ + Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. negative regulation of mononuclear cell migration + + + + Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. + GOC:mah + @@ -76085,8 +111031,15 @@ + Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. positive regulation of mononuclear cell migration + + + + Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. + GOC:mah + @@ -76111,8 +111064,15 @@ + Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. protein localization to extracellular region + + + + Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. + GOC:mah + @@ -76143,8 +111103,15 @@ + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. anatomical structure maturation + + + + A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. + GOC:mah + @@ -76169,8 +111136,15 @@ + The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. ectodermal placode development + + + + The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. + GOC:mah + @@ -76201,8 +111175,15 @@ + The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. ectodermal placode morphogenesis + + + + The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. + GOC:mah + @@ -76227,8 +111208,15 @@ + The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. nitrogen compound transport + + + + The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:mah + @@ -76260,8 +111248,15 @@ + The aggregation, arrangement and bonding together of a set of components to form a membrane. membrane assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a membrane. + GOC:mah + @@ -76286,8 +111281,16 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. + Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer. basement membrane organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. + GOC:mah + @@ -76318,8 +111321,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. nuclear membrane organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. + GOC:mah + @@ -76344,8 +111354,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane. nuclear outer membrane organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane. + GOC:mah + @@ -76369,8 +111386,17 @@ + The process in which a protein is transported across a membrane. + Note that this term is not intended for use in annotating lateral movement within membranes. protein transmembrane transport + + + + The process in which a protein is transported across a membrane. + GOC:mah + GOC:vw + @@ -76395,8 +111421,15 @@ + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. protein-DNA complex organization + + + + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. + GOC:mah + @@ -76421,8 +111454,15 @@ + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. protein-RNA complex organization + + + + Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. + GOC:mah + @@ -76430,8 +111470,16 @@ + A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular component organization or biogenesis + + + + A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. + GOC:mah + @@ -76456,8 +111504,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. response to catecholamine + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. + GOC:BHF + GOC:mah + @@ -76477,8 +111533,16 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. cellular response to catecholamine stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. + GOC:BHF + GOC:mah + @@ -76503,8 +111567,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. + Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. response to norepinephrine + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. + GOC:BHF + GOC:mah + @@ -76524,8 +111597,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. + Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. cellular response to norepinephrine stimulus + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. + GOC:BHF + GOC:mah + @@ -76562,8 +111644,19 @@ + Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). leukocyte apoptotic process + + + + Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. + CL:0000738 + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + @@ -76590,8 +111683,19 @@ + Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues. + Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). macrophage apoptotic process + + + + Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues. + CL:0000235 + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + @@ -76616,8 +111720,15 @@ + The biosynthetic process resulting in the formation of DNA. DNA biosynthetic process + + + + The biosynthetic process resulting in the formation of DNA. + GOC:mah + @@ -76625,8 +111736,15 @@ + The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. cell periphery + + + + The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. + GOC:pdt + @@ -76640,8 +111758,17 @@ + An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. elastic fiber + + + + An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. + GOC:BHF + GOC:mah + PMID:20236620 + @@ -76672,8 +111799,53 @@ + The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. extracellular exosome assembly + + + + The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. + GOC:mah + GOC:tfm + PMID:19442504 + PMID:27462458 + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels. + renal system development + + + + + The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels. + GOC:mtg_kidney_jan10 + GOC:yaf + PMID:6996269 + @@ -76704,8 +111876,15 @@ + The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. stem cell proliferation + + + + The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + GOC:mtg_kidney_jan10 + @@ -76730,8 +111909,15 @@ + Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. regulation of stem cell proliferation + + + + Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. + GOC:mtg_kidney_jan10 + @@ -76768,8 +111954,15 @@ + The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. mesenchyme morphogenesis + + + + The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. + GOC:mtg_kidney_jan10 + @@ -76800,8 +111993,15 @@ + The developmental process pertaining to the initial formation of an epithelial tube. epithelial tube formation + + + + The developmental process pertaining to the initial formation of an epithelial tube. + GOC:mtg_kidney_jan10 + @@ -76827,8 +112027,82 @@ + Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. negative regulation of mesenchymal cell proliferation + + + + Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. + GOC:mtg_kidney_jan10 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + monocarboxylic acid catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + monocarboxylic acid biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. + GOC:mah + @@ -76853,8 +112127,16 @@ + The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. circulatory system development + + + + The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. + GOC:mah + UBERON:0001009 + @@ -76885,8 +112167,17 @@ + The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis. vascular cord development + + + + The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis. + GOC:mah + PMID:7084422 + ZFA:0005077 + @@ -76910,8 +112201,15 @@ + The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. organelle transport along microtubule + + + + The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. + GOC:mah + @@ -76940,8 +112238,16 @@ + The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. + Note that this term is not intended for use in annotating lateral movement within membranes. ammonium transmembrane transport + + + + The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. + GOC:mah + @@ -76966,8 +112272,131 @@ + A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. fibroblast activation + + + + A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. + CL:0000057 + GOC:BHF + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + These processes continue to 60 DPA in Gossypium spp. + type B pancreatic cell maturation + + + + + A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. + CL:0000169 + GOC:BHF + + + + + + + + + + + + + + + + + + + + + + + + + + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver. + epithelial cell proliferation involved in liver morphogenesis + + + + + The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver. + GOC:BHF + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which the anatomical structures of the liver are generated and organized. + liver morphogenesis + + + + + The process in which the anatomical structures of the liver are generated and organized. + GOC:mah + @@ -76992,8 +112421,18 @@ + Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. endothelial cell apoptotic process + + + + Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. + CL:0000115 + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + @@ -77018,8 +112457,15 @@ + The chemical reactions and pathways involving diatomic oxygen (O2). oxygen metabolic process + + + + The chemical reactions and pathways involving diatomic oxygen (O2). + GOC:mah + @@ -77039,8 +112485,15 @@ + The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. establishment of protein localization to organelle + + + + The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. + GOC:mah + @@ -77060,8 +112513,15 @@ + A process in which a protein is transported to, or maintained in, a specific location in a membrane. protein localization to membrane + + + + A process in which a protein is transported to, or maintained in, a specific location in a membrane. + GOC:mah + @@ -77096,8 +112556,15 @@ + A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. protein localization to plasma membrane + + + + A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. + GOC:mah + @@ -77122,8 +112589,15 @@ + A process in which a protein is transported to, or maintained at, a location in a vacuole. protein localization to vacuole + + + + A process in which a protein is transported to, or maintained at, a location in a vacuole. + GOC:ecd + @@ -77143,8 +112617,15 @@ + The directed movement of a protein to a specific location in a vacuole. establishment of protein localization to vacuole + + + + The directed movement of a protein to a specific location in a vacuole. + GOC:mah + @@ -77169,8 +112650,17 @@ + The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. multinuclear osteoclast differentiation + + + + The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. + CL:0000779 + GOC:mah + PMID:12713016 + @@ -77195,8 +112685,17 @@ + The movement of a lymphocyte within or between different tissues and organs of the body. lymphocyte migration + + + + The movement of a lymphocyte within or between different tissues and organs of the body. + CL:0000542 + GOC:BHF + GOC:mah + @@ -77221,8 +112720,17 @@ + The movement of a T cell within or between different tissues and organs of the body. T cell migration + + + + The movement of a T cell within or between different tissues and organs of the body. + CL:0000084 + GOC:BHF + GOC:mah + @@ -77247,8 +112755,15 @@ + A process in which a protein is transported to, or maintained in, the cell cortex. protein localization to cell cortex + + + + A process in which a protein is transported to, or maintained in, the cell cortex. + GOC:mah + @@ -77273,8 +112788,15 @@ + A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. protein localization to microtubule cytoskeleton + + + + A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. + GOC:mah + @@ -77299,8 +112821,15 @@ + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. regulation of primary metabolic process + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. + PMID:19211694 + @@ -77325,8 +112854,16 @@ + Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. regulation of response to stress + + + + Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). + GOC:dhl + @@ -77351,8 +112888,16 @@ + Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). regulation of fertilization + + + + Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). + GOC:DHL + PMID:20478994 + @@ -77377,8 +112922,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. lytic vacuole organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. + PMID:20729380 + @@ -77404,8 +112956,15 @@ + The aggregation, arrangement and bonding together of the extracellular matrix. extracellular matrix assembly + + + + The aggregation, arrangement and bonding together of the extracellular matrix. + GOC:jl + @@ -77430,8 +112989,16 @@ + An action potential that occurs in a cardiac muscle cell. cardiac muscle cell action potential + + + + An action potential that occurs in a cardiac muscle cell. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77462,8 +113029,16 @@ + An action potential that occurs in a sinoatrial node cardiac muscle cell. SA node cell action potential + + + + An action potential that occurs in a sinoatrial node cardiac muscle cell. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77494,8 +113069,16 @@ + An action potential that occurs in an atrioventricular node cardiac muscle cell. AV node cell action potential + + + + An action potential that occurs in an atrioventricular node cardiac muscle cell. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77526,8 +113109,16 @@ + An action potential that occurs in a Purkinje myocyte. Purkinje myocyte action potential + + + + An action potential that occurs in a Purkinje myocyte. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77536,8 +113127,16 @@ + Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. SA node cell to atrial cardiac muscle cell signaling + + + + Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77557,8 +113156,16 @@ + Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. cell-cell signaling involved in cardiac conduction + + + + Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77567,8 +113174,16 @@ + Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. AV node cell to bundle of His cell signaling + + + + Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77604,8 +113219,16 @@ + Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell. Purkinje myocyte to ventricular cardiac muscle cell signaling + + + + Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77630,8 +113253,16 @@ + Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. cell communication involved in cardiac conduction + + + + Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77639,8 +113270,16 @@ + The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. AV node cell to bundle of His cell communication + + + + The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77648,8 +113287,16 @@ + The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Purkinje myocyte to ventricular cardiac muscle cell communication + + + + The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77657,8 +113304,16 @@ + The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. SA node cell to atrial cardiac muscle cell communication + + + + The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -77684,8 +113339,16 @@ + Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. regulation of monocyte chemotaxis + + + + Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. + GOC:dph + GOC:tb + @@ -77712,8 +113375,16 @@ + Any process that increases the frequency, rate, or extent of monocyte chemotaxis. positive regulation of monocyte chemotaxis + + + + Any process that increases the frequency, rate, or extent of monocyte chemotaxis. + GOC:dph + GOC:tb + @@ -77740,8 +113411,16 @@ + Any process that decreases the frequency, rate, or extent of monocyte chemotaxis. negative regulation of monocyte chemotaxis + + + + Any process that decreases the frequency, rate, or extent of monocyte chemotaxis. + GOC:dph + GOC:tb + @@ -77767,8 +113446,16 @@ + Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. positive regulation of microtubule nucleation + + + + Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. + GOC:dph + GOC:tb + @@ -77794,8 +113481,16 @@ + Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. positive regulation of cell cycle process + + + + Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. + GOC:dph + GOC:tb + @@ -77820,8 +113515,16 @@ + Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. regulation of ribosome biogenesis + + + + Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. + GOC:dph + GOC:tb + @@ -77847,8 +113550,16 @@ + Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. positive regulation of ribosome biogenesis + + + + Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. + GOC:dph + GOC:tb + @@ -77874,8 +113585,16 @@ + Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. negative regulation of ribosome biogenesis + + + + Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. + GOC:dph + GOC:tb + @@ -77900,8 +113619,16 @@ + Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. regulation of peptide transport + + + + Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. + GOC:dph + GOC:tb + @@ -77927,8 +113654,16 @@ + Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. positive regulation of extracellular matrix disassembly + + + + Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. + GOC:dph + GOC:tb + @@ -77936,8 +113671,17 @@ + The process in which the population of cells that make up a tissue undergo directed movement. tissue migration + + + + The process in which the population of cells that make up a tissue undergo directed movement. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -77945,8 +113689,17 @@ + The process in which the population of cells that make up an epithelium undergo directed movement. epithelium migration + + + + The process in which the population of cells that make up an epithelium undergo directed movement. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -77966,8 +113719,17 @@ + Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. regulation of actin cytoskeleton organization by cell-cell adhesion + + + + Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -77987,8 +113749,17 @@ + The directed movement of a protein to a specific location in a membrane. establishment of protein localization to membrane + + + + The directed movement of a protein to a specific location in a membrane. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78013,8 +113784,17 @@ + The specification and formation of anisotropic intracellular organization of an epithelial cell. establishment of epithelial cell polarity + + + + The specification and formation of anisotropic intracellular organization of an epithelial cell. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78046,8 +113826,17 @@ + A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance. Golgi disassembly + + + + A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78062,8 +113851,17 @@ + The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. Golgi reassembly + + + + The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78088,8 +113886,17 @@ + Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division. regulation of Golgi inheritance + + + + Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78120,8 +113927,17 @@ + The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte. chondrocyte morphogenesis + + + + The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78147,8 +113963,17 @@ + The joining of two lipid bilayers to form a single organelle membrane. organelle membrane fusion + + + + The joining of two lipid bilayers to form a single organelle membrane. + GOC:ascb_2009 + GOC:dph + GOC:tb + @@ -78173,8 +113998,16 @@ + Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. regulation of muscle system process + + + + Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. + GOC:dph + GOC:tb + @@ -78199,8 +114032,15 @@ + Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. regulation of somatostatin secretion + + + + Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF + @@ -78226,8 +114066,15 @@ + Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. positive regulation of somatostatin secretion + + + + Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF + @@ -78253,8 +114100,15 @@ + Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. negative regulation of somatostatin secretion + + + + Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. + GOC:BHF + @@ -78280,8 +114134,15 @@ + Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. regulation of peptide hormone secretion + + + + Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb + @@ -78308,8 +114169,15 @@ + Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. positive regulation of peptide hormone secretion + + + + Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb + @@ -78336,8 +114204,15 @@ + Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. negative regulation of peptide hormone secretion + + + + Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. + GOC:tb + @@ -78362,8 +114237,15 @@ + Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. regulation of osteoclast proliferation + + + + Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. + GOC:tb + @@ -78389,8 +114271,15 @@ + Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. positive regulation of osteoclast proliferation + + + + Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. + GOC:tb + @@ -78416,8 +114305,15 @@ + Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. negative regulation of osteoclast proliferation + + + + Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. + GOC:tb + @@ -78443,8 +114339,15 @@ + Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. regulation of neural crest formation + + + + Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. + GOC:tb + @@ -78470,8 +114373,15 @@ + Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. positive regulation of neural crest formation + + + + Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. + GOC:tb + @@ -78497,8 +114407,15 @@ + Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. negative regulation of neural crest formation + + + + Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. + GOC:tb + @@ -78525,8 +114442,15 @@ + Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. positive regulation of intracellular protein transport + + + + Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. + GOC:tb + @@ -78553,8 +114477,159 @@ + Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. negative regulation of intracellular protein transport + + + + Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + regulation of locomotion involved in locomotory behavior + + + + + Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + positive regulation of locomotion involved in locomotory behavior + + + + + Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + negative regulation of locomotion involved in locomotory behavior + + + + + Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. + GOC:dph + GOC:kmv + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. + acinar cell differentiation + + + + + The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. + GOC:dph + GOC:tb + @@ -78579,8 +114654,15 @@ + A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. protein localization to nuclear envelope + + + + A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. + GOC:tb + @@ -78619,8 +114701,16 @@ + The directed movement of catecholamine into a cell. catecholamine uptake + + + + The directed movement of catecholamine into a cell. + GOC:dph + GOC:tb + @@ -78645,8 +114735,16 @@ + The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism. mesenchymal cell migration + + + + The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism. + GOC:dph + GOC:tb + @@ -78677,8 +114775,16 @@ + Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. sensory organ morphogenesis + + + + Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GOC:kmv + ISBN:978-0199210893 + @@ -78703,8 +114809,16 @@ + A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus. RNA localization to nucleus + + + + A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus. + GOC:mah + PMID:26305931 + @@ -78729,8 +114843,15 @@ + Any membrane that is part of a pigment granule. pigment granule membrane + + + + Any membrane that is part of a pigment granule. + PMID:11294610 + @@ -78755,8 +114876,19 @@ + All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. + Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". ciliary plasm + + + + All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. + GOC:BHF + GOC:cilia + GOC:dos + PMID:17895364 + @@ -78781,8 +114913,18 @@ + Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. + Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals. dendritic cell dendrite assembly + + + + Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. + CL:0000451 + GOC:BHF + PMID:12200351 + @@ -78807,8 +114949,17 @@ + The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. + Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. dendritic cell differentiation + + + + The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. + CL:0000451 + GOC:pr + @@ -78833,8 +114984,18 @@ + Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. dendritic cell apoptotic process + + + + Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. + CL:0000451 + GOC:BHF + GOC:mtg_apoptosis + PMID:15059845 + @@ -78859,8 +115020,54 @@ + Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. motor neuron apoptotic process + + + + Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. + CL:0000100 + GOC:BHF + GOC:mtg_apoptosis + PMID:14523086 + + + + + + + + + + + + + + + + + + + + + + + + + + Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. + type B pancreatic cell apoptotic process + + + + + Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. + CL:0000169 + GOC:BHF + GOC:mtg_apoptosis + PMID:16087305 + @@ -78885,8 +115092,16 @@ + A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. synaptic membrane + + + + A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. + GOC:BHF + PMID:20410104 + @@ -78917,8 +115132,15 @@ + The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. vascular associated smooth muscle cell development + + + + The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. + GOC:BHF + @@ -78943,8 +115165,18 @@ + Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. mesenchymal cell apoptotic process + + + + Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. + CL:0000134 + GOC:mtg_apoptosis + GOC:yaf + PMID:18231833 + @@ -78969,8 +115201,17 @@ + The chemical reactions and pathways involving the ammonium ion. ammonium ion metabolic process + + + + The chemical reactions and pathways involving the ammonium ion. + GOC:dhl + GOC:tb + PMID:14671018 + @@ -78984,8 +115225,16 @@ + The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. + This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. apoptotic signaling pathway + + + + The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. + GOC:mtg_apoptosis + @@ -79005,8 +115254,16 @@ + A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. execution phase of apoptosis + + + + A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. + GOC:mtg_apoptosis + PMID:21760595 + @@ -79037,8 +115294,149 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. lysosomal membrane organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. + GOC:yaf + PMID:20544854 + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. + cellular response to toxic substance + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. + GOC:pr + + + + + + + + + + The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. + renal tubular secretion + + + + + The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. + GOC:rph + PMID:25287933 + Wikipedia:Renal_secretion#Secretion + + + + + + + + + + + + + + + + + + + + + + + + + + Any biological process involved in the maintenance of an internal steady state of ammonium. + ammonium homeostasis + + + + + Any biological process involved in the maintenance of an internal steady state of ammonium. + GOC:yaf + PMID:12695560 + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell. + intracellular ammonium homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell. + GOC:yaf + PMID:12695560 + + + + + + + + + + + + + + + + + + + + + + + + + + Any apoptotic process in a hepatocyte, the main structural component of the liver. + hepatocyte apoptotic process + + + + + Any apoptotic process in a hepatocyte, the main structural component of the liver. + CL:0000182 + GOC:jc + GOC:mtg_apoptosis + PMID:15856020 + @@ -79063,8 +115461,15 @@ + Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin. protein localization to heterochromatin + + + + Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin. + GOC:mah + @@ -79089,8 +115494,15 @@ + A prolongation or process extending from a glial cell. glial cell projection + + + + A prolongation or process extending from a glial cell. + GOC:mc + @@ -79115,8 +115527,17 @@ + The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron. neuroblast migration + + + + The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron. + CL:0000031 + GOC:jc + PMID:15543145 + @@ -79136,8 +115557,16 @@ + An arrangement of closely apposed microtubules running parallel to each other. + NIF_Subcellular:sao1872343973 microtubule bundle + + + + An arrangement of closely apposed microtubules running parallel to each other. + NIF_Subcellular:sao1872343973 + @@ -79162,8 +115591,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. supramolecular fiber organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. + GOC:pr + @@ -79189,8 +115625,17 @@ + Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina. retinal rod cell apoptotic process + + + + Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina. + CL:0000604 + GOC:jc + PMID:17202487 + @@ -79216,8 +115661,16 @@ + Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina. retinal cone cell apoptotic process + + + + Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina. + CL:0000573 + GOC:jc + @@ -79242,8 +115695,17 @@ + The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. motor neuron migration + + + + The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. + CL:0000100 + GOC:yaf + PMID:20711475 + @@ -79268,8 +115730,17 @@ + The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. spinal cord motor neuron migration + + + + The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. + CL:0011001 + GOC:yaf + PMID:20711475 + @@ -79294,8 +115765,18 @@ + A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. dendritic cell dendrite + + + + A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells. + CL:0000451 + GOC:BHF + GOC:cjm + PMID:12200351 + @@ -79320,8 +115801,16 @@ + A cardiac myofibril is a myofibril specific to cardiac muscle cells. cardiac myofibril + + + + A cardiac myofibril is a myofibril specific to cardiac muscle cells. + GOC:cjm + GOC:devbiol + @@ -79346,8 +115835,17 @@ + The movement of a myeloid leukocyte within or between different tissues and organs of the body. myeloid leukocyte migration + + + + The movement of a myeloid leukocyte within or between different tissues and organs of the body. + GOC:cvs + PMID:22342843 + PMID:24157461 + @@ -79372,8 +115870,17 @@ + The movement of a granulocyte within or between different tissues and organs of the body. granulocyte migration + + + + The movement of a granulocyte within or between different tissues and organs of the body. + GOC:cvs + PMID:24163421 + PMID:24193336 + @@ -79398,8 +115905,16 @@ + The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage. lymphoid lineage cell migration + + + + The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage. + GOC:pr + PMID:22342843 + @@ -79425,8 +115940,17 @@ + Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. vacuole fusion + + + + Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. + GOC:pr + GOC:vw + Wikipedia:Vacuole + @@ -79446,8 +115970,15 @@ + Any vesicle that is part of the intracellular region. intracellular vesicle + + + + Any vesicle that is part of the intracellular region. + GOC:vesicles + @@ -79461,8 +115992,21 @@ + The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane. + Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella. ciliary basal body-plasma membrane docking + + + + The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane. + GOC:cilia + PMID:13978319 + PMID:23348840 + PMID:23530209 + PMID:25686250 + PMID:26981235 + @@ -79476,8 +116020,19 @@ + The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. vesicle targeting, trans-Golgi to periciliary membrane compartment + + + + The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. + GOC:cilia + PMID:20106869 + PMID:23351793 + PMID:24814148 + PMID:26485645 + @@ -79485,8 +116040,18 @@ + The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. extracellular exosome biogenesis + + + + The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. + GOC:PARL + GOC:bf + PMID:19442504 + PMID:25392495 + @@ -79515,8 +116080,16 @@ + A neuromuscular junction in which the target muscle cell is a myotube. + In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes. neuromuscular junction of myotube + + + + A neuromuscular junction in which the target muscle cell is a myotube. + GOC:dos + @@ -79542,8 +116115,15 @@ + The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract. skeletal muscle fiber differentiation + + + + The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract. + GOC:dos + @@ -79568,8 +116148,16 @@ + The lipid bilayer that forms the outer-most layer of an organelle. + Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. bounding membrane of organelle + + + + The lipid bilayer that forms the outer-most layer of an organelle. + GOC:dos + @@ -79594,8 +116182,16 @@ + A membrane that is a (regional) part of the plasma membrane. + Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. plasma membrane region + + + + A membrane that is a (regional) part of the plasma membrane. + GOC:dos + @@ -79603,8 +116199,15 @@ + The attachment of one cell to another cell via adhesion molecules. cell-cell adhesion + + + + The attachment of one cell to another cell via adhesion molecules. + GOC:dos + @@ -79629,8 +116232,15 @@ + Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. protein complex involved in cell-cell adhesion + + + + Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. + GOC:dos + @@ -79655,8 +116265,15 @@ + Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell. protein complex involved in cell adhesion + + + + Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell. + GOC:dos + @@ -79681,8 +116298,15 @@ + A collagen trimer that forms networks. network-forming collagen trimer + + + + A collagen trimer that forms networks. + PMID:21421911 + @@ -79691,8 +116315,16 @@ + A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). banded collagen fibril + + + + A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). + GOC:dos + PMID:21421911 + @@ -79712,8 +116344,15 @@ + A complex of collagen trimers such as a fibril or collagen network. complex of collagen trimers + + + + A complex of collagen trimers such as a fibril or collagen network. + GOC:dos + @@ -79722,8 +116361,16 @@ + A supramolecular complex that consists of collagen triple helices associated to form a network. collagen network + + + + A supramolecular complex that consists of collagen triple helices associated to form a network. + GOC:dos + PMID:21421911 + @@ -79748,8 +116395,16 @@ + Any collagen timer that is part of a basement membrane. basement membrane collagen trimer + + + + Any collagen timer that is part of a basement membrane. + GOC:dos + PMID:21421911 + @@ -79794,8 +116449,15 @@ + The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. import into cell + + + + The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. + GOC:dos + @@ -79815,8 +116477,16 @@ + Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity. asymmetric stem cell division + + + + Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity. + GOC:dos + PMID:18513950 + @@ -79841,8 +116511,15 @@ + A myofibril of a skeletal muscle fiber. skeletal muscle myofibril + + + + A myofibril of a skeletal muscle fiber. + GOC:dos + @@ -79862,8 +116539,15 @@ + The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes. germline stem cell asymmetric division + + + + The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes. + GOC:dos + @@ -79894,8 +116578,38 @@ + The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development. bone cell development + + + + The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. + GOC:dos + + + + + + + + + + + + + + + Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. + detoxification + + + + + Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. + GOC:dos + @@ -79927,8 +116641,15 @@ + The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. skin epidermis development + + + + The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. + GOC:dos + @@ -79948,8 +116669,15 @@ + The part of a synapse that is part of the presynaptic cell. presynapse + + + + The part of a synapse that is part of the presynaptic cell. + GOC:dos + @@ -79969,8 +116697,15 @@ + The part of a synapse that is part of the post-synaptic cell. postsynapse + + + + The part of a synapse that is part of the post-synaptic cell. + GOC:dos + @@ -79995,8 +116730,15 @@ + Any protein complex that is part of a membrane. membrane protein complex + + + + Any protein complex that is part of a membrane. + GOC:dos + @@ -80021,8 +116763,48 @@ + Any protein complex that is part of the plasma membrane. plasma membrane protein complex + + + + Any protein complex that is part of the plasma membrane. + GOC:dos + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. + regulation of renal system process + + + + + Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. + GOC:dos + @@ -80030,8 +116812,15 @@ + The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. nuclear chromosome segregation + + + + The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. + GOC:dos + @@ -80056,8 +116845,15 @@ + The directed movement of a protein along a microtubule, mediated by motor proteins. protein transport along microtubule + + + + The directed movement of a protein along a microtubule, mediated by motor proteins. + PMID:25987607 + @@ -80082,8 +116878,15 @@ + The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. lytic vacuole membrane + + + + The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. + GOC:dos + @@ -80097,8 +116900,15 @@ + A cell projection supported by an assembly of actin filaments, and which lacks microtubules. actin-based cell projection + + + + A cell projection supported by an assembly of actin filaments, and which lacks microtubules. + PMID:15661519 + @@ -80123,8 +116933,15 @@ + The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone. intramembranous bone growth + + + + The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone. + PMID:26399686 + @@ -80155,8 +116972,15 @@ + The increase in size or mass of a bone that contributes to the shaping of that bone. bone growth + + + + The increase in size or mass of a bone that contributes to the shaping of that bone. + GOC:dos + @@ -80176,8 +117000,15 @@ + The actin cytoskeleton that is part of a postsynapse. postsynaptic actin cytoskeleton + + + + The actin cytoskeleton that is part of a postsynapse. + GOC:dos + @@ -80213,8 +117044,15 @@ + The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis. vesicle-mediated transport to the plasma membrane + + + + The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis. + GOC:dos + @@ -80240,8 +117078,19 @@ + A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. synapse pruning + + + + A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. + GOC:dos + PMID:12062020 + PMID:18083105 + PMID:22632716 + PMID:29844190 + @@ -80266,8 +117115,20 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term. regulation of action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:dos + GOC:dph + GOC:go_curators + GOC:tb + ISBN:978-0-07-139011-8 + @@ -80292,8 +117153,16 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. regulation of cardiac muscle cell action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:dos + GOC:mtg_cardiac_conduct_nov11 + @@ -80319,8 +117188,16 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. regulation of AV node cell action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -80346,8 +117223,16 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. regulation of Purkinje myocyte action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -80373,8 +117258,16 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. regulation of SA node cell action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:BHF + GOC:mtg_cardiac_conduct_nov11 + @@ -80400,8 +117293,17 @@ + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. regulation of neuronal action potential + + + + Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. + GOC:dph + GOC:isa_complete + GOC:tb + @@ -80436,8 +117338,15 @@ + Cell-cell signaling from pre to post-synapse, across the synaptic cleft. anterograde trans-synaptic signaling + + + + Cell-cell signaling from pre to post-synapse, across the synaptic cleft. + GOC:dos + @@ -80472,8 +117381,15 @@ + Cell-cell signaling from post to pre-synapse, across the synaptic cleft. retrograde trans-synaptic signaling + + + + Cell-cell signaling from post to pre-synapse, across the synaptic cleft. + GOC:dos + @@ -80501,8 +117417,15 @@ + Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. retrograde trans-synaptic signaling by lipid + + + + Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. + GOC:dos + @@ -80533,8 +117456,15 @@ + Signal transduction in which the initial step occurs in a postsynapse. postsynaptic signal transduction + + + + Signal transduction in which the initial step occurs in a postsynapse. + GOC:dos + @@ -80559,8 +117489,15 @@ + Signal transduction in which the initial step occurs in a presynapse. presynaptic signal transduction + + + + Signal transduction in which the initial step occurs in a presynapse. + GOC:dos + @@ -80586,8 +117523,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. postsynaptic actin cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. + GOC:dos + @@ -80622,8 +117566,16 @@ + The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma. postsynapse of neuromuscular junction + + + + The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma. + GOC:dos + Wikipedia:Neuromuscular_junction&oldid=723623502 + @@ -80648,8 +117600,17 @@ + A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. neuronal dense core vesicle + + + + A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. + GOC:dos + ISBN:978-0-07-181001-2 + Wikipedia:Neuropeptide&oldid=713905176 + @@ -80686,8 +117647,15 @@ + Any vesicle-mediated transport that occurs in a synapse. vesicle-mediated transport in synapse + + + + Any vesicle-mediated transport that occurs in a synapse. + GOC:dos + @@ -80718,8 +117686,15 @@ + The lipid bilayer surrounding a neuronal dense core vesicle. neuronal dense core vesicle membrane + + + + The lipid bilayer surrounding a neuronal dense core vesicle. + GOC:dos + @@ -80744,8 +117719,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle. neuronal dense core vesicle organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle. + GOC:dos + @@ -80776,8 +117758,18 @@ + The aggregation, arrangement and bonding together of a set of components to form a presynapse. presynapse assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a presynapse. + GOC:PARL + GOC:bf + GOC:dos + PMID:24449494 + @@ -80808,8 +117800,17 @@ + The aggregation, arrangement and bonding together of a set of components to form a postsynapse. postsynapse assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a postsynapse. + GOC:bf + GOC:dos + GOCL:PARL + @@ -80817,8 +117818,15 @@ + A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. supramolecular complex + + + + A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. + GOC:dos + @@ -80843,8 +117851,15 @@ + A polymeric supramolecular structure. supramolecular polymer + + + + A polymeric supramolecular structure. + GOC:dos + @@ -80872,8 +117887,18 @@ + Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide. retrograde trans-synaptic signaling by neuropeptide + + + + Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide. + GOC:PARL + GOC:bf + GOC:dos + PMID:19448629 + @@ -80905,8 +117930,19 @@ + Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission + + + + Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. + GOC:PARL + GOC:bf + GOC:dos + PMID:19448629 + @@ -80931,8 +117967,16 @@ + The movement of a cellular component as a result of microtubule polymerization. microtubule polymerization based movement + + + + The movement of a cellular component as a result of microtubule polymerization. + GOC:cjm + ISBN:0815316194 + @@ -80957,8 +118001,16 @@ + A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. microtubule-based transport + + + + A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. + GOC:cjm + ISBN:0815316194 + @@ -80992,8 +118044,17 @@ + The transport of a protein driven by polymerization of a microtubule to which it is attached. microtubule polymerization based protein transport + + + + The transport of a protein driven by polymerization of a microtubule to which it is attached. + GOC:dos + GOC:vw + PMID:11018050 + @@ -81018,8 +118079,15 @@ + A microtubule-based process that results in the transport of proteins. microtubule-based protein transport + + + + A microtubule-based process that results in the transport of proteins. + GOC:vw + @@ -81045,8 +118113,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. presynaptic actin cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. + GOC:dos + @@ -81066,8 +118141,15 @@ + The actin cytoskeleton that is part of a presynapse. presynaptic actin cytoskeleton + + + + The actin cytoskeleton that is part of a presynapse. + GOC:dos + @@ -81092,8 +118174,16 @@ + Cell-cell signaling in which the ligand is carried between cells by an exosome. cell-cell signaling via exosome + + + + Cell-cell signaling in which the ligand is carried between cells by an exosome. + GOC:dos + PMID:19837038 + @@ -81113,8 +118203,16 @@ + Transynaptic signaling in which the ligand is carried across the synapse by an exosome. trans-synaptic signaling via exosome + + + + Transynaptic signaling in which the ligand is carried across the synapse by an exosome. + GOC:dos + PMID:19837038 + @@ -81139,8 +118237,15 @@ + Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. postsynaptic modulation of chemical synaptic transmission + + + + Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. + GOC:dos + @@ -81165,8 +118270,15 @@ + Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. presynaptic modulation of chemical synaptic transmission + + + + Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. + GOC:dos + @@ -81197,8 +118309,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. presynapse organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. + GOC:dos + @@ -81229,8 +118348,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. postsynapse organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. + GOC:dos + @@ -81255,8 +118381,17 @@ + Any process that modulates the physical form of a presynapse. regulation of presynapse organization + + + + Any process that modulates the physical form of a presynapse. + GOC:ai + GOC:dph + GOC:tb + @@ -81281,8 +118416,17 @@ + Any process that modulates the physical form of a postsynapse. regulation of postsynapse organization + + + + Any process that modulates the physical form of a postsynapse. + GOC:ai + GOC:dph + GOC:tb + @@ -81308,8 +118452,15 @@ + Any process that modulates the frequency, rate or extent of trans-synaptic signaling. regulation of trans-synaptic signaling + + + + Any process that modulates the frequency, rate or extent of trans-synaptic signaling. + GOC:dos + @@ -81340,8 +118491,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton. presynaptic cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton. + GOC:dos + @@ -81372,8 +118530,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. postsynaptic cytoskeleton organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. + GOC:dos + @@ -81407,8 +118572,18 @@ + Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. vesicle fusion to plasma membrane + + + + Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. + GOC:aruk + GOC:bc + ISBN:0071120009 + PMID:18618940 + @@ -81433,8 +118608,15 @@ + The lipid bilayer surrounding an exocytic vesicle. exocytic vesicle membrane + + + + The lipid bilayer surrounding an exocytic vesicle. + GOC:dos + @@ -81459,8 +118641,15 @@ + A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. secretory vesicle + + + + A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. + GOC:dos + @@ -81489,8 +118678,15 @@ + A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. supramolecular fiber + + + + A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. + GOC:dos + @@ -81519,8 +118715,15 @@ + A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. polymeric cytoskeletal fiber + + + + A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. + GOC:dos + @@ -81545,8 +118748,18 @@ + The transport of organelles or other particles from one location in the cell to another along actin filaments. actin filament-based transport + + + + The transport of organelles or other particles from one location in the cell to another along actin filaments. + GOC:dos + GOC:dph + GOC:mah + GOC:tb + @@ -81570,8 +118783,16 @@ + The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. vesicle cytoskeletal trafficking + + + + The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. + GOC:ecd + GOC:rl + @@ -81606,8 +118827,15 @@ + The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. presynaptic process involved in chemical synaptic transmission + + + + The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. + GOC:dos + @@ -81644,8 +118872,15 @@ + Cell-cell signaling to, from or within a synapse. synaptic signaling + + + + Cell-cell signaling to, from or within a synapse. + GOC:dos + @@ -81653,8 +118888,15 @@ + Cell-cell signaling in either direction across the synaptic cleft. trans-synaptic signaling + + + + Cell-cell signaling in either direction across the synaptic cleft. + GOC:dos + @@ -81679,8 +118921,15 @@ + Cell-cell signaling to or from a synapse, mediated by a peptide. synaptic signaling via neuropeptide + + + + Cell-cell signaling to or from a synapse, mediated by a peptide. + GOC:dos + @@ -81700,8 +118949,15 @@ + Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. trans-synaptic signaling by neuropeptide + + + + Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. + GOC:dos + @@ -81726,8 +118982,64 @@ + Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. trans-synaptic signaling by lipid + + + + Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. + GOC:dos + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + protein catabolic process, modulating synaptic transmission + + + + + Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. + GOC:dos + PMID:23083742 + @@ -81761,8 +119073,16 @@ + Any process that modulates synaptic transmission by regulating translation occurring at the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at synapse, modulating synaptic transmission + + + + Any process that modulates synaptic transmission by regulating translation occurring at the synapse. + GOC:dos + @@ -81782,8 +119102,16 @@ + Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling, modulating synaptic transmission + + + + Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. + GOC:dos + @@ -81807,8 +119135,16 @@ + Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by neuropeptide, modulating synaptic transmission + + + + Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. + GOC:dos + @@ -81832,8 +119168,17 @@ + Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by lipid, modulating synaptic transmission + + + + Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. + GOC:dos + PMID:21531987 + @@ -81858,8 +119203,15 @@ + Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. cytoplasmic region + + + + Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. + GOC:dos + @@ -81884,8 +119236,15 @@ + The portion of the cytoskeleton contained within the presynapse. presynaptic cytoskeleton + + + + The portion of the cytoskeleton contained within the presynapse. + GOC:dos + @@ -81910,8 +119269,129 @@ + The portion of the cytoskeleton contained within the postsynapse. postsynaptic cytoskeleton + + + + The portion of the cytoskeleton contained within the postsynapse. + GOC:dos + PMID:19889835 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates synaptic transmission by regulating protein degradation at the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation of protein catabolic process at synapse, modulating synaptic transmission + + + + + Any process that modulates synaptic transmission by regulating protein degradation at the synapse. + GOC:dos + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation of protein catabolic process at presynapse, modulating synaptic transmission + + + + + Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. + GOC:dos + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation of protein catabolic process at postsynapse, modulating synaptic transmission + + + + + Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. + GOC:dos + @@ -81940,8 +119420,16 @@ + Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at presynapse, modulating synaptic transmission + + + + Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. + GOC:dos + @@ -81970,8 +119458,16 @@ + Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at postsynapse, modulating synaptic transmission + + + + Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. + GOC:dos + @@ -82000,8 +119496,15 @@ + A process in which protein is transported from one region of the plasma membrane to another. protein transport within plasma membrane + + + + A process in which protein is transported from one region of the plasma membrane to another. + GOC:dos + @@ -82029,8 +119532,15 @@ + The directed movement of proteins along microtubules in neuron projections. axo-dendritic protein transport + + + + The directed movement of proteins along microtubules in neuron projections. + ISBN:0815316194 + @@ -82073,8 +119583,15 @@ + Any signal release from a synapse. signal release from synapse + + + + Any signal release from a synapse. + GOC:dos + @@ -82100,8 +119617,15 @@ + The complete extent of cell cortex that underlies some some region of the plasma membrane. cell cortex region + + + + The complete extent of cell cortex that underlies some some region of the plasma membrane. + GOC:dos + @@ -82126,8 +119650,16 @@ + Any action potential process that regulates skeletal muscle contraction. regulation of skeletal muscle contraction by action potential + + + + Any action potential process that regulates skeletal muscle contraction. + GOC:cjm + GOC:obol + @@ -82152,8 +119684,18 @@ + The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population. vascular endothelial cell proliferation + + + + The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population. + GOC:BHF + GOC:BHF_telomere + GOC:nc + PMID:23201774 + @@ -82191,8 +119733,17 @@ + A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis. + This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown. mitotic nuclear membrane organization + + + + A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis. + GOC:vw + PMID:15147872 + @@ -82223,8 +119774,15 @@ + The process in which a nuclear membrane is synthesized, aggregates, and bonds together. nuclear membrane biogenesis + + + + The process in which a nuclear membrane is synthesized, aggregates, and bonds together. + GOC:vw + @@ -82249,8 +119807,17 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. neuron projection organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. + GOC:aruk + GOC:bc + PMID:11585923 + @@ -82276,8 +119843,16 @@ + Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus. regulation of vesicle fusion with Golgi apparatus + + + + Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus. + GOC:se + PMID:26195667 + @@ -82303,8 +119878,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus. negative regulation of vesicle fusion with Golgi apparatus + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus. + GOC:se + PMID:26195667 + @@ -82330,8 +119913,16 @@ + Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus. positive regulation of vesicle fusion with Golgi apparatus + + + + Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus. + GOC:se + PMID:26195667 + @@ -82356,8 +119947,16 @@ + Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. regulation of basement membrane organization + + + + Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. + GOC:ha + PMID:27404358 + @@ -82382,8 +119981,16 @@ + Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. regulation of actomyosin structure organization + + + + Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. + GOC:lf + PMID:22790195 + @@ -82408,8 +120015,18 @@ + The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. cardiac muscle myoblast proliferation + + + + The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:26512644 + @@ -82434,8 +120051,18 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation. regulation of cardiac muscle myoblast proliferation + + + + Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:26512644 + @@ -82461,8 +120088,18 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation. negative regulation of cardiac muscle myoblast proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:26512644 + @@ -82488,8 +120125,18 @@ + Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation. positive regulation of cardiac muscle myoblast proliferation + + + + Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:26512644 + @@ -82515,8 +120162,15 @@ + Any process that modulates the frequency, rate or extent of actin filament organization. regulation of actin filament organization + + + + Any process that modulates the frequency, rate or extent of actin filament organization. + GOC:kmv + @@ -82541,8 +120195,18 @@ + Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation. regulation of blood vessel endothelial cell differentiation + + + + Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:23072816 + @@ -82568,8 +120232,18 @@ + Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation. positive regulation of blood vessel endothelial cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:23072816 + @@ -82595,8 +120269,18 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation. negative regulation of blood vessel endothelial cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:23072816 + @@ -82622,8 +120306,17 @@ + A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane. vesicle-mediated intercellular transport + + + + A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane. + GOC:sp + PMID:29328915 + PMID:29328916 + @@ -82650,8 +120343,15 @@ + Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. positive regulation of animal organ morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. + GOC:kmv + @@ -82678,8 +120378,128 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. negative regulation of animal organ morphogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. + GOC:kmv + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate, or extent of lipid transporter activity. + regulation of lipid transporter activity + + + + + Any process that modulates the frequency, rate, or extent of lipid transporter activity. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:27365390 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that increases the frequency, rate, or extent of lipid transporter activity. + positive regulation of lipid transporter activity + + + + + Any process that increases the frequency, rate, or extent of lipid transporter activity. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:27365390 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that decreases the frequency, rate, or extent of lipid transporter activity. + negative regulation of lipid transporter activity + + + + + Any process that decreases the frequency, rate, or extent of lipid transporter activity. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:27365390 + @@ -82704,8 +120524,16 @@ + Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation. regulation of compound eye photoreceptor cell differentiation + + + + Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation. + GOC:ha + PMID:16377567 + @@ -82731,8 +120559,16 @@ + Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation. positive regulation of compound eye photoreceptor cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation. + GOC:ha + PMID:16377567 + @@ -82758,8 +120594,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation. negative regulation of compound eye photoreceptor cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation. + GOC:ha + PMID:16377567 + @@ -82784,8 +120628,16 @@ + The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse. myotube cell migration + + + + The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse. + GOC:ha + PMID:29122742 + @@ -82810,8 +120662,16 @@ + Any process that modulates the frequency, rate or extent of myotube cell migration. regulation of myotube cell migration + + + + Any process that modulates the frequency, rate or extent of myotube cell migration. + GOC:ha + PMID:29122742 + @@ -82837,8 +120697,16 @@ + Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration. positive regulation of myotube cell migration + + + + Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration. + GOC:ha + PMID:29122742 + @@ -82864,8 +120732,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration. negative regulation of myotube cell migration + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration. + GOC:ha + PMID:29122742 + @@ -82874,8 +120750,15 @@ + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. cellular anatomical entity + + + + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. + GOC:kmv + @@ -82900,8 +120783,15 @@ + A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. plasma membrane bounded cell projection + + + + A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. + GOC:krc + @@ -82926,8 +120816,15 @@ + Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. plasma membrane bounded cell projection assembly + + + + Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. + GOC:krc + @@ -82952,8 +120849,15 @@ + Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly. regulation of plasma membrane bounded cell projection assembly + + + + Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly. + GOC:krc + @@ -82979,8 +120883,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly. negative regulation of plasma membrane bounded cell projection assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly. + GOC:krc + @@ -83007,8 +120918,15 @@ + Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. positive regulation of plasma membrane bounded cell projection assembly + + + + Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. + GOC:krc + @@ -83033,8 +120951,15 @@ + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections. regulation of plasma membrane bounded cell projection organization + + + + Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections. + GOC:krc + @@ -83059,8 +120984,15 @@ + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon. plasma membrane bounded cell projection organization + + + + A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon. + GOC:krc + @@ -83085,8 +121017,15 @@ + The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized. plasma membrane bounded cell projection morphogenesis + + + + The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized. + GOC:krc + @@ -83111,8 +121050,84 @@ + All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. neuron projection cytoplasm + + + + All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. + GOC:ha + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + positive regulation of collagen catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. + GOC:dph + GOC:tb + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. + steroid hormone biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. + GOC:krc + GOC:nln + @@ -83138,8 +121153,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin. negative regulation of protein localization to chromatin + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin. + PMID:20889714 + PMID:29899453 + @@ -83165,8 +121188,126 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to chromatin. positive regulation of protein localization to chromatin + + + + Any process that activates or increases the frequency, rate or extent of protein localization to chromatin. + PMID:20889714 + PMID:29899453 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + regulation of bile acid secretion + + + + + Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:22767443 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + positive regulation of bile acid secretion + + + + + Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:22767443 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + negative regulation of bile acid secretion + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. + GOC:BHF + GOC:BHF_miRNA + GOC:rph + PMID:22767443 + @@ -83191,8 +121332,16 @@ + Any process that modulates the frequency, rate or extent of blastocyst development. regulation of blastocyst development + + + + Any process that modulates the frequency, rate or extent of blastocyst development. + GOC:krc + PMID:29593216 + @@ -83217,8 +121366,16 @@ + A process in which a protein is transported to, or maintained in, a location within a motile cilium. protein localization to motile cilium + + + + A process in which a protein is transported to, or maintained in, a location within a motile cilium. + GOC:krc + PMID:27486780 + @@ -83243,8 +121400,15 @@ + Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism. regulation of pigmentation + + + + Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism. + GOC:krc + @@ -83275,8 +121439,16 @@ + The developmental process pertaining to the initial formation of an endothelial tube. endothelial tube formation + + + + The developmental process pertaining to the initial formation of an endothelial tube. + GOC:sl + PMID:23239824 + @@ -83296,8 +121468,15 @@ + One of the two nuclear divisions that occur as part of the meiotic cell cycle. meiotic nuclear division + + + + One of the two nuclear divisions that occur as part of the meiotic cell cycle. + PMID:9334324 + @@ -83317,8 +121496,15 @@ + A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. mitotic nuclear division + + + + A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. + ISBN:0198547684 + @@ -83343,8 +121529,15 @@ + The cellular processes that contribute to exocytosis. exocytic process + + + + The cellular processes that contribute to exocytosis. + Wikipedia:Exocytosis + @@ -83369,8 +121562,15 @@ + The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus. cell-cell adhesion in response to extracellular stimulus + + + + The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus. + PMID:14996911 + @@ -83379,8 +121579,15 @@ + The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other. organelle localization by membrane tethering + + + + The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other. + PMID:27875684 + @@ -83405,8 +121612,18 @@ + Any process that controls lipoprotein transport. regulation of lipoprotein transport + + + + Any process that controls lipoprotein transport. + GOC:BHF + GOC:BHF_miRNA + GOC:RPH + PMID:26501192 + @@ -83432,8 +121649,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport. negative regulation of lipoprotein transport + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport. + GOC:BHF + GOC:BHF_miRNA + GOC:RPH + PMID:26501192 + @@ -83459,8 +121686,154 @@ + Any process that activates or increases the rate or extent of lipoprotein transport. positive regulation of lipoprotein transport + + + + Any process that activates or increases the rate or extent of lipoprotein transport. + GOC:BHF + GOC:BHF_miRNA + GOC:RPH + PMID:26501192 + + + + + + + + + + + + + + + + + + + + + + + + + + Catalytic activity that acts to modify a protein. + catalytic activity, acting on a protein + + + + + Catalytic activity that acts to modify a protein. + GOC:molecular_function_refactoring + GOC:pdt + + + + + + + + + + + + + + + + + + + + + + + + + + Catalytic activity that acts to modify DNA. + catalytic activity, acting on DNA + + + + + Catalytic activity that acts to modify DNA. + GOC:molecular_function_refactoring + GOC:pdt + + + + + + + + + + + + + + + + + + + + + + + + + + Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. + catalytic activity, acting on RNA + + + + + Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. + GOC:molecular_function_refactoring + GOC:pdt + + + + + + + + + + + + + + + + + + + + + + + + + + Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. + catalytic activity, acting on a glycoprotein + + + + + Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. + GOC:molecular_function_refactoring + GOC:pdt + @@ -83468,8 +121841,15 @@ + The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. extracellular vesicle biogenesis + + + + The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. + PMID:28736435 + @@ -83496,8 +121876,15 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis. positive regulation of lymphocyte chemotaxis + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis. + PMID:19255442 + @@ -83522,8 +121909,16 @@ + Translation that occurs at the presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. translation at presynapse + + + + Translation that occurs at the presynapse. + PMID:27321671 + @@ -83552,8 +121947,16 @@ + Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. translation at presynapse, modulating chemical synaptic transmission + + + + Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. + PMID:27321671 + @@ -83580,8 +121983,16 @@ + A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. presynaptic endocytosis + + + + A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. + PMID:24719103 + @@ -83608,8 +122019,16 @@ + A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. postsynaptic endocytosis + + + + A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. + PMID:12839988 + @@ -83646,8 +122065,16 @@ + Translation that occurs at the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. translation at synapse + + + + Translation that occurs at the synapse. + PMID:23083742 + @@ -83672,8 +122099,16 @@ + Translation that occurs at the postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. translation at postsynapse + + + + Translation that occurs at the postsynapse. + PMID:20427644 + @@ -83714,8 +122149,16 @@ + Any process that regulates translation occurring at the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at synapse + + + + Any process that regulates translation occurring at the synapse. + PMID:20427644 + @@ -83744,8 +122187,16 @@ + Any process that regulates translation occurring at the presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at presynapse + + + + Any process that regulates translation occurring at the presynapse. + PMID:20427644 + @@ -83774,8 +122225,292 @@ + Any process that regulates translation occurring at the postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at postsynapse + + + + Any process that regulates translation occurring at the postsynapse. + PMID:20427644 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + protein catabolic process at synapse + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. + PMID:17062563 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + protein catabolic process at presynapse + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse. + PMID:27764673 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + protein catabolic process at postsynapse + + + + + The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. + PMID:17062563 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation protein catabolic process at synapse + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. + PMID:23083742 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation protein catabolic process at presynapse + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse. + PMID:27764673 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. + Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. + regulation protein catabolic process at postsynapse + + + + + Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. + PMID:17062563 + @@ -83789,8 +122524,70 @@ + A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium. cell-cell fusion + + + + A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium. + Wikipedia:Cell_fusion + + + + + + + + + + + + + + + + + + + + + + + + + + Directly binding to a specific protein and delivering it to a specific cellular location. + Reactome:R-HSA-2248891 + Reactome:R-HSA-9662747 + Reactome:R-HSA-9662818 + Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. + protein transporter activity + + + + + Directly binding to a specific protein and delivering it to a specific cellular location. + PMID:18706423 + + + + + Reactome:R-HSA-2248891 + M6PR transports activated ARSA to the lysosome + + + + + Reactome:R-HSA-9662747 + iRHOM2 transports ADAM17 from ER to the Golgi-network + + + + + Reactome:R-HSA-9662818 + iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane + @@ -83826,8 +122623,15 @@ + The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. export from cell + + + + The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. + GOC:pg + @@ -83855,8 +122659,15 @@ + The directed movement of a lipid from a cell, into the extracellular region. lipid export from cell + + + + The directed movement of a lipid from a cell, into the extracellular region. + GOC:pg + @@ -83895,8 +122706,15 @@ + The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. lipid import into cell + + + + The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. + GOC:pg + @@ -83921,8 +122739,15 @@ + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. nuclear protein-containing complex + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. + GOC:pg + @@ -83947,8 +122772,15 @@ + The division of a vacuole within a cell to form two or more separate vacuoles. vacuole fission + + + + The division of a vacuole within a cell to form two or more separate vacuoles. + PMID:19643199 + @@ -83973,8 +122805,76 @@ + The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle. non-membrane-bounded organelle assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle. + PMID:28225081 + + + + + + + + + + + + + + + + + + + + + + + + + + The elimination of ammonium ions from an excretory cell. + ammonium excretion + + + + + The elimination of ammonium ions from an excretory cell. + PMID:25740900 + + + + + + + + + + + + + + + + + + + + + A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. + multicellular organismal-level chemical homeostasis + + + + + A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell. + GOC:curators + @@ -83999,8 +122899,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to lysosome. regulation of protein localization to lysosome + + + + Any process that modulates the frequency, rate or extent of protein localization to lysosome. + GOC:aruk + GOC:bc + PMID:24305806 + @@ -84026,8 +122935,16 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to lysosome. positive regulation of protein localization to lysosome + + + + Any process that activates or increases the frequency, rate or extent of protein localization to lysosome. + GOC:aruk + GOC:bc + @@ -84053,8 +122970,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome. negative regulation of protein localization to lysosome + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome. + GOC:aruk + GOC:bc + PMID:24305806 + @@ -84079,8 +123005,19 @@ + Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. regulation of postsynapse assembly + + + + Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. + GOC:aruk + GOC:bc + PMID:16394100 + PMID:16672654 + PMID:28185854 + @@ -84088,8 +123025,20 @@ + The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. visual system development + + + + The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. + GOC:aruk + GOC:bc + GOC:krc + PMID:15004427 + PMID:20647017 + PMID:22632727 + @@ -84097,8 +123046,19 @@ + The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents. neuroinflammatory response + + + + The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents. + GOC:aruk + GOC:bc + PMID:10981966 + PMID:11099416 + PMID:18164423 + @@ -84135,8 +123095,19 @@ + Any process that modulates the frequency, rate or extent of neuroinflammatory response. regulation of neuroinflammatory response + + + + Any process that modulates the frequency, rate or extent of neuroinflammatory response. + GOC:aruk + GOC:bc + PMID:10981966 + PMID:11099416 + PMID:18164423 + @@ -84162,8 +123133,16 @@ + Any process that activates or increases the frequency, rate or extent of neuroinflammatory response. positive regulation of neuroinflammatory response + + + + Any process that activates or increases the frequency, rate or extent of neuroinflammatory response. + GOC:aruk + GOC:bc + @@ -84189,8 +123168,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response. negative regulation of neuroinflammatory response + + + + Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response. + GOC:aruk + GOC:bc + PMID:11099416 + PMID:18164423 + @@ -84225,8 +123214,22 @@ + Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum. glial cell-neuron signaling + + + + Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum. + GOC:aruk + GOC:bc + PMID:14980203 + PMID:16144764 + PMID:16547515 + PMID:18685038 + PMID:27788368 + PMID:9459440 + @@ -84261,8 +123264,24 @@ + Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine. neuron-glial cell signaling + + + + Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine. + GOC:aruk + GOC:bc + PMID:10195197 + PMID:10196584 + PMID:10377338 + PMID:10493741 + PMID:11356870 + PMID:11399439 + PMID:15252819 + PMID:27788368 + @@ -84287,8 +123306,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation. negative regulation of monocyte activation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation. + GOC:aruk + PMID:15597323 + @@ -84313,8 +123340,17 @@ + A process in which a protein is transported to, or maintained, in a location within a cell-cell junction. protein localization to cell-cell junction + + + + A process in which a protein is transported to, or maintained, in a location within a cell-cell junction. + GOC:aruk + GOC:bc + PMID:26706435 + @@ -84339,8 +123375,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction. regulation of protein localization to cell-cell junction + + + + Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction. + GOC:aruk + GOC:bc + PMID:26706435 + @@ -84366,8 +123411,17 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction. positive regulation of protein localization to cell-cell junction + + + + Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction. + GOC:aruk + GOC:bc + PMID:26706435 + @@ -84392,8 +123446,16 @@ + Any process that modulates the frequency, rate or extent of transepithelial transport. regulation of transepithelial transport + + + + Any process that modulates the frequency, rate or extent of transepithelial transport. + GOC:aruk + PMID:27593915 + @@ -84419,8 +123481,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction. negative regulation of protein localization to cell-cell junction + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction. + GOC:aruk + GOC:bc + @@ -84445,8 +123515,16 @@ + The disaggregation of a cell junction into its constituent components. cell junction disassembly + + + + The disaggregation of a cell junction into its constituent components. + GOC:aruk + PMID:25490267 + @@ -84471,8 +123549,16 @@ + The disaggregation of a cell-cell junction into its constituent components. cell-cell junction disassembly + + + + The disaggregation of a cell-cell junction into its constituent components. + GOC:aruk + PMID:25490267 + @@ -84497,8 +123583,16 @@ + The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain. somatic sensory system development + + + + The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain. + PMID:25832476 + PMID:31399790 + @@ -84523,8 +123617,43 @@ + The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure. chordate pharynx development + + + + The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure. + PMID:23020903 + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a lipid from one side of a membrane to the other. + lipid transmembrane transporter activity + + + + + Enables the transfer of a lipid from one side of a membrane to the other. + GOC:curators + @@ -84549,8 +123678,15 @@ + Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. regulation of cytokine production involved in inflammatory response + + + + Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. + GOC:TermGenie + @@ -84576,8 +123712,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response. negative regulation of cytokine production involved in inflammatory response + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response. + GOC:TermGenie + @@ -84603,8 +123746,122 @@ + Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response. positive regulation of cytokine production involved in inflammatory response + + + + Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. + regulation of cellular response to insulin stimulus + + + + + Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. + GOC:TermGenie + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. + negative regulation of cellular response to insulin stimulus + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. + GOC:TermGenie + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. + positive regulation of cellular response to insulin stimulus + + + + + Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. + GOC:TermGenie + GOC:yaf + @@ -84629,8 +123886,16 @@ + Any regulation of signal transduction that takes place in the extracellular region. extracellular regulation of signal transduction + + + + Any regulation of signal transduction that takes place in the extracellular region. + GOC:TermGenie + GOC:signaling + @@ -84650,8 +123915,16 @@ + Any negative regulation of signal transduction that takes place in extracellular region. extracellular negative regulation of signal transduction + + + + Any negative regulation of signal transduction that takes place in extracellular region. + GOC:TermGenie + GOC:signaling + @@ -84676,8 +123949,16 @@ + Any process that modulates the frequency, rate or extent of execution phase of apoptosis. regulation of execution phase of apoptosis + + + + Any process that modulates the frequency, rate or extent of execution phase of apoptosis. + GOC:TermGenie + GOC:mtg_apoptosis + @@ -84703,8 +123984,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. negative regulation of execution phase of apoptosis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. + GOC:TermGenie + GOC:mtg_apoptosis + @@ -84730,8 +124019,16 @@ + Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. positive regulation of execution phase of apoptosis + + + + Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. + GOC:TermGenie + GOC:mtg_apoptosis + @@ -84756,8 +124053,16 @@ + Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process. regulation of hyaluronan biosynthetic process + + + + Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process. + GOC:TermGenie + GOC:yaf + @@ -84784,8 +124089,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. negative regulation of hyaluronan biosynthetic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. + GOC:TermGenie + GOC:yaf + @@ -84812,8 +124125,16 @@ + Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process. positive regulation of hyaluronan biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process. + GOC:TermGenie + GOC:yaf + @@ -84840,8 +124161,17 @@ + Any process that modulates the frequency, rate or extent of defense response to fungus. regulation of defense response to fungus + + + + Any process that modulates the frequency, rate or extent of defense response to fungus. + GOC:TermGenie + GOC:dhl + PMID:22242006 + @@ -84866,8 +124196,15 @@ + Any process that modulates the frequency, rate or extent of protein localization to nucleus. regulation of protein localization to nucleus + + + + Any process that modulates the frequency, rate or extent of protein localization to nucleus. + GOC:TermGenie + @@ -84893,8 +124230,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. negative regulation of protein localization to nucleus + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. + GOC:TermGenie + @@ -84920,8 +124264,15 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. positive regulation of protein localization to nucleus + + + + Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. + GOC:TermGenie + @@ -84947,8 +124298,16 @@ + Any process that modulates the frequency, rate or extent of oocyte maturation. regulation of oocyte maturation + + + + Any process that modulates the frequency, rate or extent of oocyte maturation. + GOC:TermGenie + GOC:kmv + @@ -84975,8 +124334,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation. negative regulation of oocyte maturation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation. + GOC:TermGenie + GOC:kmv + @@ -85003,8 +124370,16 @@ + Any process that activates or increases the frequency, rate or extent of oocyte maturation. positive regulation of oocyte maturation + + + + Any process that activates or increases the frequency, rate or extent of oocyte maturation. + GOC:TermGenie + GOC:kmv + @@ -85030,8 +124405,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect. negative regulation of defense response to insect + + + + Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect. + GOC:TermGenie + PMID:22474183 + @@ -85057,8 +124440,16 @@ + Any process that activates or increases the frequency, rate or extent of defense response to insect. positive regulation of defense response to insect + + + + Any process that activates or increases the frequency, rate or extent of defense response to insect. + GOC:TermGenie + PMID:22474183 + @@ -85085,8 +124476,16 @@ + Any process that modulates the frequency, rate or extent of defense response to bacterium. regulation of defense response to bacterium + + + + Any process that modulates the frequency, rate or extent of defense response to bacterium. + GOC:TermGenie + PMID:22346749 + @@ -85114,8 +124513,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. negative regulation of defense response to bacterium + + + + Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. + GOC:TermGenie + PMID:22346749 + @@ -85143,8 +124550,109 @@ + Any process that activates or increases the frequency, rate or extent of defense response to bacterium. positive regulation of defense response to bacterium + + + + Any process that activates or increases the frequency, rate or extent of defense response to bacterium. + GOC:TermGenie + PMID:22346749 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving insulin. + insulin metabolic process + + + + + The chemical reactions and pathways involving insulin. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of insulin. + insulin catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of insulin. + GOC:TermGenie + @@ -85169,8 +124677,17 @@ + Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form. gene expression involved in extracellular matrix organization + + + + Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form. + GOC:TermGenie + GOC:pg + PMID:18668558 + @@ -85195,8 +124712,48 @@ + The chemical reactions and pathways involving primary amino compound. primary amino compound metabolic process + + + + The chemical reactions and pathways involving primary amino compound. + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of primary amino compound. + primary amino compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of primary amino compound. + GOC:TermGenie + @@ -85221,8 +124778,15 @@ + The chemical reactions and pathways resulting in the formation of primary amino compound. primary amino compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of primary amino compound. + GOC:TermGenie + @@ -85247,8 +124811,16 @@ + Any process that modulates the frequency, rate or extent of trophoblast cell migration. regulation of trophoblast cell migration + + + + Any process that modulates the frequency, rate or extent of trophoblast cell migration. + GOC:BHF + GOC:TermGenie + @@ -85276,8 +124848,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration. negative regulation of trophoblast cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration. + GOC:BHF + GOC:TermGenie + @@ -85306,8 +124886,16 @@ + Any process that activates or increases the frequency, rate or extent of trophoblast cell migration. positive regulation of trophoblast cell migration + + + + Any process that activates or increases the frequency, rate or extent of trophoblast cell migration. + GOC:BHF + GOC:TermGenie + @@ -85332,8 +124920,16 @@ + Any neural crest cell migration that is involved in autonomic nervous system development. neural crest cell migration involved in autonomic nervous system development + + + + Any neural crest cell migration that is involved in autonomic nervous system development. + GOC:BHF + GOC:TermGenie + @@ -85358,8 +124954,15 @@ + Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex. regulation of formation of translation initiation ternary complex + + + + Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex. + GOC:TermGenie + @@ -85386,8 +124989,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex. negative regulation of formation of translation initiation ternary complex + + + + Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex. + GOC:TermGenie + @@ -85413,8 +125023,15 @@ + Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex. positive regulation of formation of translation initiation ternary complex + + + + Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex. + GOC:TermGenie + @@ -85440,8 +125057,16 @@ + Any process that modulates the frequency, rate or extent of extracellular matrix assembly. regulation of extracellular matrix assembly + + + + Any process that modulates the frequency, rate or extent of extracellular matrix assembly. + GOC:BHF + GOC:TermGenie + @@ -85467,8 +125092,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. negative regulation of extracellular matrix assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. + GOC:BHF + GOC:TermGenie + @@ -85495,8 +125128,16 @@ + Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. positive regulation of extracellular matrix assembly + + + + Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. + GOC:BHF + GOC:TermGenie + @@ -85521,8 +125162,16 @@ + Any process that modulates the frequency, rate or extent of cardiac chamber formation. regulation of cardiac chamber formation + + + + Any process that modulates the frequency, rate or extent of cardiac chamber formation. + GOC:BHF + GOC:TermGenie + @@ -85548,8 +125197,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation. negative regulation of cardiac chamber formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation. + GOC:BHF + GOC:TermGenie + @@ -85575,8 +125232,16 @@ + Any process that activates or increases the frequency, rate or extent of cardiac chamber formation. positive regulation of cardiac chamber formation + + + + Any process that activates or increases the frequency, rate or extent of cardiac chamber formation. + GOC:BHF + GOC:TermGenie + @@ -85601,8 +125266,16 @@ + Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis. regulation of cardiac chamber morphogenesis + + + + Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis. + GOC:BHF + GOC:TermGenie + @@ -85628,8 +125301,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis. negative regulation of cardiac chamber morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis. + GOC:BHF + GOC:TermGenie + @@ -85655,8 +125336,16 @@ + Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis. positive regulation of cardiac chamber morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis. + GOC:BHF + GOC:TermGenie + @@ -85681,8 +125370,16 @@ + Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation. regulation of lung ciliated cell differentiation + + + + Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation. + GOC:BHF + GOC:TermGenie + @@ -85709,8 +125406,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation. negative regulation of lung ciliated cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation. + GOC:BHF + GOC:TermGenie + @@ -85737,8 +125442,16 @@ + Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation. positive regulation of lung ciliated cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation. + GOC:BHF + GOC:TermGenie + @@ -85763,8 +125476,15 @@ + Any process that modulates the frequency, rate or extent of vasculature development. regulation of vasculature development + + + + Any process that modulates the frequency, rate or extent of vasculature development. + GOC:TermGenie + @@ -85791,8 +125511,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. negative regulation of vasculature development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. + GOC:TermGenie + @@ -85817,8 +125544,16 @@ + Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis. regulation of endothelial tube morphogenesis + + + + Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis. + GOC:TermGenie + GOC:dph + @@ -85843,8 +125578,17 @@ + Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. regulation of hematopoietic progenitor cell differentiation + + + + Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + @@ -85870,8 +125614,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. negative regulation of hematopoietic progenitor cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + @@ -85897,8 +125650,17 @@ + Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. positive regulation of hematopoietic progenitor cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + @@ -85924,8 +125686,17 @@ + Any process that modulates the frequency, rate or extent of endothelial cell development. regulation of endothelial cell development + + + + Any process that modulates the frequency, rate or extent of endothelial cell development. + GOC:TermGenie + GOC:pr + PMID:19470579 + @@ -85952,8 +125723,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development. negative regulation of endothelial cell development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development. + GOC:TermGenie + GOC:pr + PMID:19470579 + @@ -85979,8 +125759,17 @@ + Any process that activates or increases the frequency, rate or extent of endothelial cell development. positive regulation of endothelial cell development + + + + Any process that activates or increases the frequency, rate or extent of endothelial cell development. + GOC:TermGenie + GOC:pr + PMID:19470579 + @@ -86005,8 +125794,50 @@ + The chemical reactions and pathways involving organonitrogen compound. organonitrogen compound metabolic process + + + + The chemical reactions and pathways involving organonitrogen compound. + GOC:TermGenie + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. + organonitrogen compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. + GOC:TermGenie + GOC:pr + @@ -86032,8 +125863,16 @@ + The chemical reactions and pathways resulting in the formation of organonitrogen compound. organonitrogen compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of organonitrogen compound. + GOC:TermGenie + GOC:pr + @@ -86058,8 +125897,15 @@ + Any process that modulates the frequency, rate or extent of vesicle transport along microtubule. regulation of vesicle transport along microtubule + + + + Any process that modulates the frequency, rate or extent of vesicle transport along microtubule. + GOC:TermGenie + @@ -86085,8 +125931,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule. negative regulation of vesicle transport along microtubule + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule. + GOC:TermGenie + @@ -86112,8 +125965,15 @@ + Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule. positive regulation of vesicle transport along microtubule + + + + Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule. + GOC:TermGenie + @@ -86138,8 +125998,50 @@ + The chemical reactions and pathways involving organic hydroxy compound. organic hydroxy compound metabolic process + + + + The chemical reactions and pathways involving organic hydroxy compound. + GOC:TermGenie + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. + organic hydroxy compound catabolic process + + + + + The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. + GOC:TermGenie + GOC:pr + @@ -86165,8 +126067,50 @@ + The chemical reactions and pathways resulting in the formation of organic hydroxy compound. organic hydroxy compound biosynthetic process + + + + The chemical reactions and pathways resulting in the formation of organic hydroxy compound. + GOC:TermGenie + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of organic hydroxy compound from one side of a membrane to the other. + organic hydroxy compound transmembrane transporter activity + + + + + Enables the transfer of organic hydroxy compound from one side of a membrane to the other. + GOC:TermGenie + GOC:pr + @@ -86192,8 +126136,15 @@ + Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. regulation of lymphocyte chemotaxis + + + + Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. + GOC:TermGenie + @@ -86220,8 +126171,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis. negative regulation of lymphocyte chemotaxis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis. + GOC:TermGenie + @@ -86246,8 +126204,16 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. response to peptide + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. + GOC:TermGenie + GOC:pr + @@ -86267,8 +126233,79 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. cellular response to peptide + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. + GOC:TermGenie + GOC:pr + + + + + + + + + + + + + + + + + + + + + + + + + + A response that results in a state of tolerance to ketone. + response to ketone + + + + + A response that results in a state of tolerance to ketone. + GOC:mengo_curators + PMID:23356676 + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. + cellular response to ketone + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. + GOC:TermGenie + GOC:pr + @@ -86293,8 +126330,17 @@ + Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process. regulation of compound eye retinal cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process. + GOC:TermGenie + GOC:mtg_apoptosis + PMID:12021768 + @@ -86320,8 +126366,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process. negative regulation of compound eye retinal cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process. + GOC:TermGenie + GOC:mtg_apoptosis + PMID:12021768 + @@ -86348,8 +126403,17 @@ + Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process. positive regulation of compound eye retinal cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process. + GOC:TermGenie + GOC:mtg_apoptosis + PMID:12021768 + @@ -86374,8 +126438,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. response to nitrogen compound + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. + GOC:TermGenie + GOC:pr + @@ -86395,8 +126468,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. + Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular response to nitrogen compound + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. + GOC:TermGenie + GOC:pr + @@ -86421,8 +126503,17 @@ + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state. mesenchymal cell differentiation involved in bone development + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state. + GOC:TermGenie + GOC:hjd + PMID:21571217 + @@ -86447,8 +126538,17 @@ + Any process that modulates the frequency, rate or extent of muscle tissue development. regulation of muscle tissue development + + + + Any process that modulates the frequency, rate or extent of muscle tissue development. + GOC:TermGenie + GOC:yaf + PMID:23150719 + @@ -86474,8 +126574,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. negative regulation of muscle tissue development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. + GOC:TermGenie + GOC:yaf + PMID:23150719 + @@ -86501,8 +126610,17 @@ + Any process that activates or increases the frequency, rate or extent of muscle tissue development. positive regulation of muscle tissue development + + + + Any process that activates or increases the frequency, rate or extent of muscle tissue development. + GOC:TermGenie + GOC:yaf + PMID:23150719 + @@ -86527,8 +126645,18 @@ + Any process that modulates the frequency, rate or extent of protein depolymerization. regulation of protein depolymerization + + + + Any process that modulates the frequency, rate or extent of protein depolymerization. + GOC:BHF + GOC:TermGenie + GOC:rl + PMID:12032137 + @@ -86554,8 +126682,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization. negative regulation of protein depolymerization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization. + GOC:BHF + GOC:TermGenie + GOC:rl + PMID:12032137 + @@ -86581,8 +126719,18 @@ + Any process that activates or increases the frequency, rate or extent of protein depolymerization. positive regulation of protein depolymerization + + + + Any process that activates or increases the frequency, rate or extent of protein depolymerization. + GOC:BHF + GOC:TermGenie + GOC:rl + PMID:12032137 + @@ -86608,8 +126756,15 @@ + Any process that modulates the frequency, rate or extent of cell junction assembly. regulation of cell junction assembly + + + + Any process that modulates the frequency, rate or extent of cell junction assembly. + GOC:TermGenie + @@ -86635,8 +126790,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. negative regulation of cell junction assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. + GOC:TermGenie + @@ -86663,8 +126825,15 @@ + Any process that activates or increases the frequency, rate or extent of cell junction assembly. positive regulation of cell junction assembly + + + + Any process that activates or increases the frequency, rate or extent of cell junction assembly. + GOC:TermGenie + @@ -86689,8 +126858,18 @@ + Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. regulation of cell proliferation involved in outflow tract morphogenesis + + + + Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_heart + PMID:21419760 + @@ -86716,8 +126895,18 @@ + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. positive regulation of cell proliferation involved in outflow tract morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_heart + PMID:21419760 + @@ -86769,8 +126958,18 @@ + Any process that modulates the frequency, rate or extent of cilium assembly. regulation of cilium assembly + + + + Any process that modulates the frequency, rate or extent of cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:dph + PMID:17719545 + @@ -86797,8 +126996,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. negative regulation of cilium assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:dph + PMID:17719545 + @@ -86823,8 +127032,17 @@ + Any process that modulates the frequency, rate or extent of cilium-dependent cell motility. regulation of cilium-dependent cell motility + + + + Any process that modulates the frequency, rate or extent of cilium-dependent cell motility. + GOC:TermGenie + GOC:cilia + GOC:jl + @@ -86850,8 +127068,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility. negative regulation of cilium-dependent cell motility + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility. + GOC:TermGenie + GOC:cilia + GOC:jl + @@ -86876,8 +127103,16 @@ + Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation. regulation of hematopoietic stem cell proliferation + + + + Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation. + GOC:TermGenie + PMID:23403623 + @@ -86904,8 +127139,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation. negative regulation of hematopoietic stem cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation. + GOC:TermGenie + PMID:23403623 + @@ -86931,8 +127174,16 @@ + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation. positive regulation of hematopoietic stem cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation. + GOC:TermGenie + PMID:23403623 + @@ -86958,8 +127209,16 @@ + Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. regulation of hematopoietic stem cell differentiation + + + + Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. + GOC:TermGenie + PMID:23403623 + @@ -86986,8 +127245,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation. negative regulation of hematopoietic stem cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation. + GOC:TermGenie + PMID:23403623 + @@ -87014,8 +127281,16 @@ + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation. positive regulation of hematopoietic stem cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation. + GOC:TermGenie + PMID:23403623 + @@ -87040,8 +127315,16 @@ + Any process that modulates the frequency, rate or extent of leukocyte differentiation. regulation of leukocyte differentiation + + + + Any process that modulates the frequency, rate or extent of leukocyte differentiation. + GOC:TermGenie + GOC:add + @@ -87067,8 +127350,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. negative regulation of leukocyte differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. + GOC:TermGenie + GOC:add + @@ -87094,8 +127385,16 @@ + Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. positive regulation of leukocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. + GOC:TermGenie + GOC:add + @@ -87121,8 +127420,16 @@ + Any process that modulates the frequency, rate or extent of organelle assembly. regulation of organelle assembly + + + + Any process that modulates the frequency, rate or extent of organelle assembly. + GOC:TermGenie + GOC:pr + @@ -87148,8 +127455,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. negative regulation of organelle assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. + GOC:TermGenie + GOC:pr + @@ -87176,8 +127491,16 @@ + Any process that activates or increases the frequency, rate or extent of organelle assembly. positive regulation of organelle assembly + + + + Any process that activates or increases the frequency, rate or extent of organelle assembly. + GOC:TermGenie + GOC:pr + @@ -87228,8 +127551,19 @@ + Any apoptotic process in an erythrocyte. erythrocyte apoptotic process + + + + Any apoptotic process in an erythrocyte. + GOC:BHF + GOC:TermGenie + GOC:mtg_apoptosis + GOC:rl + PMID:14569084 + @@ -87254,8 +127588,19 @@ + Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process. regulation of erythrocyte apoptotic process + + + + Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process. + GOC:BHF + GOC:TermGenie + GOC:mtg_apoptosis + GOC:rl + PMID:14569084 + @@ -87307,8 +127652,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process. negative regulation of erythrocyte apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process. + GOC:BHF + GOC:TermGenie + GOC:mtg_apoptosis + GOC:rl + PMID:14569084 + @@ -87360,8 +127716,19 @@ + Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process. positive regulation of erythrocyte apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process. + GOC:BHF + GOC:TermGenie + GOC:mtg_apoptosis + GOC:rl + PMID:14569084 + @@ -87386,8 +127753,18 @@ + Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. regulation of apoptotic process involved in outflow tract morphogenesis + + + + Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_apoptosis + PMID:16839542 + @@ -87413,8 +127790,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. negative regulation of apoptotic process involved in outflow tract morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_apoptosis + PMID:16839542 + @@ -87440,8 +127827,18 @@ + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. positive regulation of apoptotic process involved in outflow tract morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_apoptosis + PMID:16839542 + @@ -87466,8 +127863,18 @@ + Any apoptotic process that is involved in blood vessel morphogenesis. apoptotic process involved in blood vessel morphogenesis + + + + Any apoptotic process that is involved in blood vessel morphogenesis. + GOC:TermGenie + GOC:dph + GOC:mtg_apoptosis + PMID:16163358 + @@ -87492,8 +127899,19 @@ + Any process that modulates the frequency, rate or extent of chromatin organization. regulation of chromatin organization + + + + Any process that modulates the frequency, rate or extent of chromatin organization. + GOC:TermGenie + GOC:bf + GOC:vw + GO_REF:0000058 + PMID:18314879 + @@ -87518,8 +127936,17 @@ + Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis. regulation of apoptotic process involved in morphogenesis + + + + Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis. + GOC:TermGenie + GOC:sart + PMID:12202035 + @@ -87545,8 +127972,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis. negative regulation of apoptotic process involved in morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis. + GOC:TermGenie + GOC:sart + PMID:12202035 + @@ -87572,8 +128008,17 @@ + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis. positive regulation of apoptotic process involved in morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis. + GOC:TermGenie + GOC:sart + PMID:12202035 + @@ -87599,8 +128044,51 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation. negative regulation of chromosome condensation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation. + GOC:TermGenie + PMID:23219725 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. + negative regulation of RNA catabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. + GOC:TermGenie + GOC:bf + PMID:16640457 + @@ -87625,8 +128113,16 @@ + A process in which a protein is transported to, or maintained in, a location within a cell junction. protein localization to cell junction + + + + A process in which a protein is transported to, or maintained in, a location within a cell junction. + GOC:TermGenie + PMID:18332111 + @@ -87651,8 +128147,17 @@ + A process in which a protein is transported to, or maintained in, a location within a cell leading edge. protein localization to cell leading edge + + + + A process in which a protein is transported to, or maintained in, a location within a cell leading edge. + GOC:TermGenie + GOC:lb + PMID:21543326 + @@ -87677,8 +128182,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to synapse. regulation of protein localization to synapse + + + + Any process that modulates the frequency, rate or extent of protein localization to synapse. + GOC:TermGenie + GOC:kmv + PMID:22588719 + @@ -87704,8 +128218,265 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to synapse. positive regulation of protein localization to synapse + + + + Any process that activates or increases the frequency, rate or extent of protein localization to synapse. + GOC:TermGenie + GOC:kmv + PMID:22588719 + + + + + + + + + + + + + + + + + + + + + + + + + + Any apoptotic process in a cholangiocyte. + cholangiocyte apoptotic process + + + + + Any apoptotic process in a cholangiocyte. + GOC:TermGenie + PMID:22961800 + + + + + + + + + + + + + + + + + + + + + + + + + + Any apoptotic process in a hepatoblast. + hepatoblast apoptotic process + + + + + Any apoptotic process in a hepatoblast. + GOC:TermGenie + PMID:22412967 + + + + + + + + + + + + + + + + + + + + + + + + + + A protein complex which is capable of catalytic activity. + catalytic complex + + + + + A protein complex which is capable of catalytic activity. + GOC:TermGenie + GOC:bhm + PMID:8077207 + + + + + + + + + + + + + + + + + + + + + + + + + + + A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. + transmembrane transporter complex + + + + + A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. + GOC:TermGenie + GOC:bhm + PMID:18024586 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation. + DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). + regulation of apoptotic DNA fragmentation + + + + + Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation. + GOC:TermGenie + GOC:hjd + PMID:15572351 + PMID:15723341 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation. + negative regulation of apoptotic DNA fragmentation + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation. + GOC:TermGenie + GOC:hjd + PMID:15572351 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation. + positive regulation of apoptotic DNA fragmentation + + + + + Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation. + GOC:TermGenie + GOC:hjd + PMID:15572351 + @@ -87731,8 +128502,17 @@ + Any process that modulates the frequency, rate or extent of organelle transport along microtubule. regulation of organelle transport along microtubule + + + + Any process that modulates the frequency, rate or extent of organelle transport along microtubule. + GOC:TermGenie + GOC:dph + PMID:21147087 + @@ -87757,8 +128537,18 @@ + Any process that modulates the frequency, rate or extent of intracellular signal transduction. regulation of intracellular signal transduction + + + + Any process that modulates the frequency, rate or extent of intracellular signal transduction. + GOC:TermGenie + GOC:dph + GOC:signaling + GOC:tb + @@ -87784,8 +128574,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. negative regulation of intracellular signal transduction + + + + Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. + GOC:TermGenie + GOC:dph + GOC:signaling + GOC:tb + @@ -87811,8 +128611,19 @@ + Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. positive regulation of intracellular signal transduction + + + + Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. + GOC:BHF + GOC:TermGenie + GOC:dph + GOC:signaling + GOC:tb + @@ -87837,8 +128648,16 @@ + A process in which a protein is transported to, or maintained in, a location within a nucleolus. protein localization to nucleolus + + + + A process in which a protein is transported to, or maintained in, a location within a nucleolus. + GOC:TermGenie + PMID:22809626 + @@ -87864,8 +128683,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. negative regulation of RNA biosynthetic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. + GO:jl + GOC:TermGenie + GO_REF:0000058 + @@ -87891,8 +128719,17 @@ + Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process. positive regulation of RNA biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process. + GO:jl + GOC:TermGenie + GO_REF:0000058 + @@ -87917,8 +128754,19 @@ + Any process that modulates the frequency, rate or extent of neuroblast proliferation. regulation of neuroblast proliferation + + + + Any process that modulates the frequency, rate or extent of neuroblast proliferation. + GOC:PARL + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:21168496 + @@ -87945,8 +128793,17 @@ + Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. regulation of chondrocyte differentiation involved in endochondral bone morphogenesis + + + + Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. + GOC:TermGenie + GO_REF:0000058 + PMID:8662546 + @@ -87971,8 +128828,18 @@ + Any apoptotic process that is involved in anatomical structure development. apoptotic process involved in development + + + + Any apoptotic process that is involved in anatomical structure development. + GOC:TermGenie + GOC:mtg_apoptosis + GOC:pg + GO_REF:0000060 + @@ -87999,8 +128866,18 @@ + Any process that activates or increases the frequency, rate or extent of chondrocyte development. positive regulation of chondrocyte development + + + + Any process that activates or increases the frequency, rate or extent of chondrocyte development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16575901 + @@ -88026,8 +128903,18 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation. regulation of skeletal muscle fiber differentiation + + + + Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:17879321 + @@ -88054,8 +128941,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation. negative regulation of skeletal muscle fiber differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:17879321 + @@ -88082,8 +128979,18 @@ + Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation. positive regulation of skeletal muscle fiber differentiation + + + + Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:17879321 + @@ -88108,8 +129015,18 @@ + Any process that modulates the frequency, rate or extent of protein localization to microtubule. regulation of protein localization to microtubule + + + + Any process that modulates the frequency, rate or extent of protein localization to microtubule. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + PMID:23087209 + @@ -88135,8 +129052,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule. negative regulation of protein localization to microtubule + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + PMID:23087209 + @@ -88161,8 +129088,17 @@ + Any process that modulates the frequency, rate or extent of nuclear migration along microtubule. regulation of nuclear migration along microtubule + + + + Any process that modulates the frequency, rate or extent of nuclear migration along microtubule. + GOC:TermGenie + GO_REF:0000058 + PMID:23087209 + @@ -88188,8 +129124,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule. negative regulation of nuclear migration along microtubule + + + + Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule. + GOC:TermGenie + GO_REF:0000058 + PMID:23087209 + @@ -88215,8 +129160,17 @@ + Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule. positive regulation of nuclear migration along microtubule + + + + Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule. + GOC:TermGenie + GO_REF:0000058 + PMID:23087209 + @@ -88236,8 +129190,17 @@ + Any microtubule cytoskeleton organization that is involved in mitosis. microtubule cytoskeleton organization involved in mitosis + + + + Any microtubule cytoskeleton organization that is involved in mitosis. + GOC:TermGenie + GO_REF:0000060 + PMID:18799626 + @@ -88262,8 +129225,18 @@ + Any process that modulates the frequency, rate or extent of embryonic camera-type eye development. regulation of embryonic camera-type eye development + + + + Any process that modulates the frequency, rate or extent of embryonic camera-type eye development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88289,8 +129262,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development. negative regulation of embryonic camera-type eye development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88316,8 +129299,18 @@ + Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development. positive regulation of embryonic camera-type eye development + + + + Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88342,8 +129335,18 @@ + Any process that modulates the frequency, rate or extent of retina development in camera-type eye. regulation of retina development in camera-type eye + + + + Any process that modulates the frequency, rate or extent of retina development in camera-type eye. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88370,8 +129373,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye. negative regulation of retina development in camera-type eye + + + + Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88398,8 +129411,18 @@ + Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye. positive regulation of retina development in camera-type eye + + + + Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88424,8 +129447,18 @@ + Any process that modulates the frequency, rate or extent of embryonic pattern specification. regulation of embryonic pattern specification + + + + Any process that modulates the frequency, rate or extent of embryonic pattern specification. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88451,8 +129484,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification. negative regulation of embryonic pattern specification + + + + Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88478,8 +129521,18 @@ + Any process that activates or increases the frequency, rate or extent of embryonic pattern specification. positive regulation of embryonic pattern specification + + + + Any process that activates or increases the frequency, rate or extent of embryonic pattern specification. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16872597 + @@ -88504,8 +129557,20 @@ + Any process that modulates the frequency, rate or extent of supramolecular fiber organization. + HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro regulation of supramolecular fiber organization + + + + Any process that modulates the frequency, rate or extent of supramolecular fiber organization. + GOC:PARL + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23921388 + @@ -88531,8 +129596,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization. + HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro negative regulation of supramolecular fiber organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization. + GOC:PARL + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23921388 + @@ -88558,8 +129635,20 @@ + Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization. + HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro positive regulation of supramolecular fiber organization + + + + Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization. + GOC:PARL + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23921388 + @@ -88584,8 +129673,18 @@ + Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation. positive regulation of neuroepithelial cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:16916506 + @@ -88610,8 +129709,16 @@ + The disaggregation of an organelle into its constituent components. organelle disassembly + + + + The disaggregation of an organelle into its constituent components. + GOC:TermGenie + GO_REF:0000079 + @@ -88636,8 +129743,18 @@ + Any process that modulates the frequency, rate or extent of bone development. regulation of bone development + + + + Any process that modulates the frequency, rate or extent of bone development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:22510437 + @@ -88664,8 +129781,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of bone development. negative regulation of bone development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of bone development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:22510437 + @@ -88692,8 +129819,18 @@ + Any process that activates or increases the frequency, rate or extent of bone development. positive regulation of bone development + + + + Any process that activates or increases the frequency, rate or extent of bone development. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:22510437 + @@ -88718,8 +129855,20 @@ + Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. + human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein regulation of glycoprotein metabolic process + + + + Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23544079 + @@ -88745,8 +129894,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. + human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein negative regulation of glycoprotein metabolic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23544079 + @@ -88772,8 +129933,20 @@ + Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. + human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein positive regulation of glycoprotein metabolic process + + + + Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:23544079 + @@ -88798,8 +129971,20 @@ + Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion. + Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion regulation of leukocyte cell-cell adhesion + + + + Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:21106532 + @@ -88825,8 +130010,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion. + Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion negative regulation of leukocyte cell-cell adhesion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:21106532 + @@ -88852,8 +130049,20 @@ + Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion. + Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion positive regulation of leukocyte cell-cell adhesion + + + + Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:21106532 + @@ -88878,8 +130087,20 @@ + Any neural crest cell migration that is involved in sympathetic nervous system development. + Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development neural crest cell migration involved in sympathetic nervous system development + + + + Any neural crest cell migration that is involved in sympathetic nervous system development. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000060 + PMID:19325129 + @@ -88906,8 +130127,17 @@ + A process that is part of the meiotic cell cycle. meiotic cell cycle process + + + + A process that is part of the meiotic cell cycle. + GOC:TermGenie + GOC:mtg_cell_cycle + GO_REF:0000060 + @@ -88932,8 +130162,17 @@ + A process that is part of the mitotic cell cycle. mitotic cell cycle process + + + + A process that is part of the mitotic cell cycle. + GOC:TermGenie + GOC:mtg_cell_cycle + GO_REF:0000060 + @@ -88958,8 +130197,19 @@ + Any process that modulates the frequency, rate or extent of extracellular matrix organization. regulation of extracellular matrix organization + + + + Any process that modulates the frequency, rate or extent of extracellular matrix organization. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:22357537 + @@ -88985,8 +130235,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. negative regulation of extracellular matrix organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:22357537 + @@ -89012,8 +130273,19 @@ + Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. positive regulation of extracellular matrix organization + + + + Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:22357537 + @@ -89038,8 +130310,19 @@ + Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. regulation of protein localization to plasma membrane + + + + Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:11602640 + @@ -89065,8 +130348,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. negative regulation of protein localization to plasma membrane + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:11602640 + @@ -89092,8 +130386,19 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. positive regulation of protein localization to plasma membrane + + + + Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:11602640 + @@ -89118,8 +130423,17 @@ + Any process that modulates the frequency, rate or extent of actin filament-based movement. regulation of actin filament-based movement + + + + Any process that modulates the frequency, rate or extent of actin filament-based movement. + GOC:TermGenie + GO_REF:0000058 + PMID:24798735 + @@ -89145,8 +130459,17 @@ + Any process that activates or increases the frequency, rate or extent of actin filament-based movement. positive regulation of actin filament-based movement + + + + Any process that activates or increases the frequency, rate or extent of actin filament-based movement. + GOC:TermGenie + GO_REF:0000058 + PMID:24798735 + @@ -89171,8 +130494,17 @@ + A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton. protein localization to actin cytoskeleton + + + + A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton. + GOC:TermGenie + GO_REF:0000087 + PMID:24798735 + @@ -89197,8 +130529,17 @@ + A process in which a protein is transported to, or maintained in, the location of an actin filament bundle. protein localization to actin filament bundle + + + + A process in which a protein is transported to, or maintained in, the location of an actin filament bundle. + GOC:TermGenie + GO_REF:0000087 + PMID:24798735 + @@ -89223,8 +130564,18 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. mononuclear cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. + CL:0000842 + GOC:TermGenie + GO_REF:0000086 + PMID:24759906 + @@ -89249,8 +130600,18 @@ + Any process that modulates the frequency, rate or extent of endodermal cell differentiation. regulation of endodermal cell differentiation + + + + Any process that modulates the frequency, rate or extent of endodermal cell differentiation. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23154389 + @@ -89276,8 +130637,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation. negative regulation of endodermal cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23154389 + @@ -89303,8 +130674,18 @@ + Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation. positive regulation of endodermal cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23154389 + @@ -89329,8 +130710,19 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell. multi-ciliated epithelial cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell. + GOC:TermGenie + GOC:sp + GO_REF:0000086 + PMID:22231168 + PMID:24934224 + @@ -89355,8 +130747,17 @@ + A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. protein localization to Golgi membrane + + + + A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. + GOC:TermGenie + GO_REF:0000087 + PMID:11378902 + @@ -89381,8 +130782,17 @@ + Any process that modulates the frequency, rate or extent of vacuolar transport. regulation of vacuolar transport + + + + Any process that modulates the frequency, rate or extent of vacuolar transport. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + @@ -89408,8 +130818,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport. negative regulation of vacuolar transport + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + @@ -89435,8 +130854,17 @@ + Any process that activates or increases the frequency, rate or extent of vacuolar transport. positive regulation of vacuolar transport + + + + Any process that activates or increases the frequency, rate or extent of vacuolar transport. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + @@ -89461,8 +130889,17 @@ + Any process that modulates the frequency, rate or extent of nucleus organization. regulation of nucleus organization + + + + Any process that modulates the frequency, rate or extent of nucleus organization. + GOC:TermGenie + GO_REF:0000058 + PMID:16943282 + @@ -89487,8 +130924,18 @@ + Any process that modulates the frequency, rate or extent of Golgi organization. regulation of Golgi organization + + + + Any process that modulates the frequency, rate or extent of Golgi organization. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:17562788 + @@ -89514,8 +130961,17 @@ + Any process that modulates the frequency, rate or extent of mitotic chromosome condensation. regulation of mitotic chromosome condensation + + + + Any process that modulates the frequency, rate or extent of mitotic chromosome condensation. + GOC:TermGenie + GO_REF:0000058 + PMID:9490640 + @@ -89542,8 +130998,86 @@ + Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation. positive regulation of mitotic chromosome condensation + + + + Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation. + GOC:TermGenie + GO_REF:0000058 + PMID:9490640 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. + response to bile acid + + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000071 + PMID:21757002 + + + + + + + + + + + + + + + + + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. + cellular response to bile acid + + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000071 + PMID:21757002 + @@ -89568,8 +131102,17 @@ + Any process that modulates the frequency, rate or extent of cell maturation. regulation of cell maturation + + + + Any process that modulates the frequency, rate or extent of cell maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:17459944 + @@ -89595,8 +131138,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. negative regulation of cell maturation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:17459944 + @@ -89622,8 +131174,17 @@ + Any process that activates or increases the frequency, rate or extent of cell maturation. positive regulation of cell maturation + + + + Any process that activates or increases the frequency, rate or extent of cell maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:17459944 + @@ -89648,8 +131209,55 @@ + A process in which a protein is transported to, or maintained in, a location within a ciliary membrane. protein localization to ciliary membrane + + + + A process in which a protein is transported to, or maintained in, a location within a ciliary membrane. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000087 + PMID:22139371 + + + + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving mucopolysaccharide. + mucopolysaccharide metabolic process + + + + + The chemical reactions and pathways involving mucopolysaccharide. + GOC:TermGenie + GOC:dph + GO_REF:0000068 + PMID:4236091 + @@ -89674,8 +131282,18 @@ + Any process that modulates the frequency, rate or extent of blood circulation. regulation of blood circulation + + + + Any process that modulates the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + @@ -89701,8 +131319,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. negative regulation of blood circulation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + @@ -89728,8 +131356,18 @@ + Any process that activates or increases the frequency, rate or extent of blood circulation. positive regulation of blood circulation + + + + Any process that activates or increases the frequency, rate or extent of blood circulation. + GOC:TermGenie + GOC:mr + GO_REF:0000058 + PMID:10659969 + @@ -89755,8 +131393,18 @@ + Any process that modulates the frequency, rate or extent of secretion by cell. regulation of secretion by cell + + + + Any process that modulates the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + @@ -89783,8 +131431,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. negative regulation of secretion by cell + + + + Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + @@ -89811,8 +131469,18 @@ + Any process that activates or increases the frequency, rate or extent of secretion by cell. positive regulation of secretion by cell + + + + Any process that activates or increases the frequency, rate or extent of secretion by cell. + GOC:TermGenie + GOC:pm + GO_REF:0000058 + PMID:12130530 + @@ -89837,8 +131505,18 @@ + Any meiotic cell cycle process that is involved in oocyte maturation. meiotic cell cycle process involved in oocyte maturation + + + + Any meiotic cell cycle process that is involved in oocyte maturation. + GOC:TermGenie + GOC:jz + GO_REF:0000060 + PMID:25212395 + @@ -89864,8 +131542,18 @@ + Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. regulation of meiotic cell cycle process involved in oocyte maturation + + + + Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. + GOC:TermGenie + GOC:jz + GO_REF:0000058 + PMID:25212395 + @@ -89890,8 +131578,17 @@ + Any process that modulates the frequency, rate or extent of exosomal secretion. regulation of exosomal secretion + + + + Any process that modulates the frequency, rate or extent of exosomal secretion. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -89917,8 +131614,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion. negative regulation of exosomal secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -89945,8 +131651,17 @@ + Any process that activates or increases the frequency, rate or extent of exosomal secretion. positive regulation of exosomal secretion + + + + Any process that activates or increases the frequency, rate or extent of exosomal secretion. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -89971,8 +131686,17 @@ + Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly. regulation of extracellular exosome assembly + + + + Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -89998,8 +131722,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly. negative regulation of extracellular exosome assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -90025,8 +131758,17 @@ + Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly. positive regulation of extracellular exosome assembly + + + + Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly. + GOC:TermGenie + GO_REF:0000058 + PMID:24105262 + @@ -90046,8 +131788,18 @@ + Any vesicle that is part of the extracellular region. extracellular vesicle + + + + Any vesicle that is part of the extracellular region. + GOC:TermGenie + GOC:pm + GO_REF:0000064 + PMID:24769233 + @@ -90072,8 +131824,19 @@ + Any process that modulates the frequency, rate or extent of protein localization to cilium. regulation of protein localization to cilium + + + + Any process that modulates the frequency, rate or extent of protein localization to cilium. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + @@ -90099,8 +131862,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium. negative regulation of protein localization to cilium + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + @@ -90126,8 +131900,19 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to cilium. positive regulation of protein localization to cilium + + + + Any process that activates or increases the frequency, rate or extent of protein localization to cilium. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + @@ -90152,8 +131937,19 @@ + Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane. regulation of protein localization to ciliary membrane + + + + Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + @@ -90179,8 +131975,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane. negative regulation of protein localization to ciliary membrane + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + @@ -90206,8 +132013,126 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane. positive regulation of protein localization to ciliary membrane + + + + Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:22072986 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of DNA catabolic process. + regulation of DNA catabolic process + + + + + Any process that modulates the frequency, rate or extent of DNA catabolic process. + GOC:TermGenie + GO_REF:0000058 + PMID:2001740 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process. + negative regulation of DNA catabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process. + GOC:TermGenie + GO_REF:0000058 + PMID:2001740 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of DNA catabolic process. + positive regulation of DNA catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of DNA catabolic process. + GOC:TermGenie + GO_REF:0000058 + PMID:2001740 + @@ -90233,8 +132158,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly. negative regulation of microvillus assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:22797597 + @@ -90260,8 +132195,18 @@ + Any process that activates or increases the frequency, rate or extent of microvillus assembly. positive regulation of microvillus assembly + + + + Any process that activates or increases the frequency, rate or extent of microvillus assembly. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:22797597 + @@ -90286,8 +132231,17 @@ + The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure. substantia propria of cornea development + + + + The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure. + GOC:TermGenie + GO_REF:0000094 + PMID:12556382 + @@ -90312,8 +132266,17 @@ + The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure. esophagus development + + + + The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure. + GOC:TermGenie + GO_REF:0000094 + ISBN:0-683-40008-8 + @@ -90340,8 +132303,20 @@ + Any process that modulates the frequency, rate or extent of hemopoiesis. + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. regulation of hemopoiesis + + + + Any process that modulates the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 + @@ -90369,8 +132344,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. negative regulation of hemopoiesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 + @@ -90398,8 +132385,20 @@ + Any process that activates or increases the frequency, rate or extent of hemopoiesis. + An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. positive regulation of hemopoiesis + + + + Any process that activates or increases the frequency, rate or extent of hemopoiesis. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:20080761 + @@ -90424,8 +132423,17 @@ + Any process that modulates the frequency, rate or extent of plasma membrane organization. regulation of plasma membrane organization + + + + Any process that modulates the frequency, rate or extent of plasma membrane organization. + GOC:TermGenie + GO_REF:0000058 + PMID:24514900 + @@ -90450,8 +132458,17 @@ + A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane. protein localization to vacuolar membrane + + + + A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane. + GOC:TermGenie + GO_REF:0000087 + PMID:25378562 + @@ -90476,8 +132493,20 @@ + Any process that modulates the frequency, rate or extent of cardiac conduction. regulation of cardiac conduction + + + + Any process that modulates the frequency, rate or extent of cardiac conduction. + GOC:BHF + GOC:TermGenie + GOC:mtg_cardiac_conduct_nov11 + GOC:rph + GO_REF:0000058 + PMID:12967627 + @@ -90503,8 +132532,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction. negative regulation of cardiac conduction + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction. + GOC:BHF + GOC:TermGenie + GOC:mtg_cardiac_conduct_nov11 + GOC:rph + GO_REF:0000058 + PMID:12967627 + @@ -90530,8 +132571,53 @@ + Any process that activates or increases the frequency, rate or extent of cardiac conduction. positive regulation of cardiac conduction + + + + Any process that activates or increases the frequency, rate or extent of cardiac conduction. + GOC:BHF + GOC:TermGenie + GOC:mtg_cardiac_conduct_nov11 + GOC:rph + GO_REF:0000058 + PMID:12967627 + + + + + + + + + + + + + + + + + + + + + + + + + The process in which an organic acid is transported across a membrane. + organic acid transmembrane transport + + + + + The process in which an organic acid is transported across a membrane. + GOC:TermGenie + GO_REF:0000069 + @@ -90557,8 +132643,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. negative regulation of protein localization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + @@ -90584,8 +132679,17 @@ + Any process that activates or increases the frequency, rate or extent of a protein localization. positive regulation of protein localization + + + + Any process that activates or increases the frequency, rate or extent of a protein localization. + GOC:TermGenie + GOC:vw + GO_REF:0000058 + @@ -90610,8 +132714,17 @@ + Any signal transduction that is involved in cellular response to ammonium ion. signal transduction involved in cellular response to ammonium ion + + + + Any signal transduction that is involved in cellular response to ammonium ion. + GOC:TermGenie + GO_REF:0000060 + PMID:16297994 + @@ -90636,8 +132749,20 @@ + Any process that modulates the frequency, rate or extent of aorta morphogenesis. regulation of aorta morphogenesis + + + + Any process that modulates the frequency, rate or extent of aorta morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22269326 + @@ -90663,8 +132788,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis. negative regulation of aorta morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22269326 + @@ -90690,8 +132827,20 @@ + Any process that activates or increases the frequency, rate or extent of aorta morphogenesis. positive regulation of aorta morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of aorta morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22269326 + @@ -90716,8 +132865,17 @@ + The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure. extraembryonic membrane development + + + + The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure. + GOC:TermGenie + GO_REF:0000094 + ISBN:0073040584 + @@ -90742,8 +132900,18 @@ + Any process that modulates the frequency, rate or extent of establishment of T cell polarity. regulation of establishment of T cell polarity + + + + Any process that modulates the frequency, rate or extent of establishment of T cell polarity. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23575248 + @@ -90769,8 +132937,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity. negative regulation of establishment of T cell polarity + + + + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23575248 + @@ -90796,8 +132974,18 @@ + Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity. positive regulation of establishment of T cell polarity + + + + Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:23575248 + @@ -90823,8 +133011,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. negative regulation of respiratory gaseous exchange + + + + Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. + GOC:TermGenie + GO_REF:0000058 + PMID:22819705 + @@ -90850,8 +133047,124 @@ + Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. positive regulation of respiratory gaseous exchange + + + + Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. + GOC:TermGenie + GO_REF:0000058 + PMID:22819705 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process. + regulation of hepatocyte apoptotic process + + + + + Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:8649852 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process. + negative regulation of hepatocyte apoptotic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:8649852 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process. + positive regulation of hepatocyte apoptotic process + + + + + Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:8649852 + @@ -90877,8 +133190,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential. negative regulation of AV node cell action potential + + + + Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential. + GOC:BHF + GOC:TermGenie + GOC:mtg_cardiac_conduct_nov11 + GOC:nc + GO_REF:0000058 + PMID:25281747 + @@ -90904,8 +133229,20 @@ + Any process that activates or increases the frequency, rate or extent of AV node cell action potential. positive regulation of AV node cell action potential + + + + Any process that activates or increases the frequency, rate or extent of AV node cell action potential. + GOC:BHF + GOC:TermGenie + GOC:mtg_cardiac_conduct_nov11 + GOC:nc + GO_REF:0000058 + PMID:25281747 + @@ -90930,8 +133267,19 @@ + Any process that modulates the frequency, rate or extent of glial cell migration. regulation of glial cell migration + + + + Any process that modulates the frequency, rate or extent of glial cell migration. + GOC:BHF + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:19100238 + @@ -90957,8 +133305,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration. negative regulation of glial cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration. + GOC:BHF + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:19100238 + @@ -90984,8 +133343,19 @@ + Any process that activates or increases the frequency, rate or extent of glial cell migration. positive regulation of glial cell migration + + + + Any process that activates or increases the frequency, rate or extent of glial cell migration. + GOC:BHF + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:19100238 + @@ -91010,8 +133380,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. response to serotonin + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:1505525 + @@ -91031,8 +133410,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. cellular response to serotonin + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:1505525 + @@ -91059,8 +133447,17 @@ + Any process that activates or increases the frequency, rate or extent of vasculature development. positive regulation of vasculature development + + + + Any process that activates or increases the frequency, rate or extent of vasculature development. + GOC:TermGenie + GO_REF:0000058 + PMID:21472453 + @@ -91111,8 +133508,17 @@ + Any apoptotic process in an epithelial cell. epithelial cell apoptotic process + + + + Any apoptotic process in an epithelial cell. + GOC:TermGenie + GO_REF:0000085 + PMID:19137015 + @@ -91138,8 +133544,17 @@ + Any process that modulates the frequency, rate or extent of collagen fibril organization. regulation of collagen fibril organization + + + + Any process that modulates the frequency, rate or extent of collagen fibril organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25451920 + @@ -91166,8 +133581,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization. negative regulation of collagen fibril organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25451920 + @@ -91194,8 +133618,17 @@ + Any process that activates or increases the frequency, rate or extent of collagen fibril organization. positive regulation of collagen fibril organization + + + + Any process that activates or increases the frequency, rate or extent of collagen fibril organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25451920 + @@ -91220,8 +133653,17 @@ + Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. regulation of epithelial cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:19137015 + @@ -91247,8 +133689,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. negative regulation of epithelial cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:19137015 + @@ -91274,8 +133725,124 @@ + Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. positive regulation of epithelial cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:19137015 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of cholangiocyte proliferation. + regulation of cholangiocyte proliferation + + + + + Any process that modulates the frequency, rate or extent of cholangiocyte proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24434010 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation. + negative regulation of cholangiocyte proliferation + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24434010 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation. + positive regulation of cholangiocyte proliferation + + + + + Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24434010 + @@ -91301,8 +133868,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. negative regulation of sensory perception of pain + + + + Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. + GOC:TermGenie + GO_REF:0000058 + PMID:17167094 + @@ -91328,8 +133904,17 @@ + Any process that activates or increases the frequency, rate or extent of sensory perception of pain. positive regulation of sensory perception of pain + + + + Any process that activates or increases the frequency, rate or extent of sensory perception of pain. + GOC:TermGenie + GO_REF:0000058 + PMID:17167094 + @@ -91355,8 +133940,17 @@ + Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation. regulation of trophectodermal cell proliferation + + + + Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24508636 + @@ -91382,8 +133976,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation. negative regulation of trophectodermal cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24508636 + @@ -91409,8 +134012,17 @@ + Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation. positive regulation of trophectodermal cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24508636 + @@ -91435,8 +134047,18 @@ + A process in which a protein is transported to, or maintained in, a location within a microvillus. protein localization to microvillus + + + + A process in which a protein is transported to, or maintained in, a location within a microvillus. + GOC:TermGenie + GOC:kmv + GO_REF:0000087 + PMID:25335890 + @@ -91464,8 +134086,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. negative regulation of meiotic cell cycle process involved in oocyte maturation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:22674394 + @@ -91492,8 +134123,17 @@ + Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. positive regulation of meiotic cell cycle process involved in oocyte maturation + + + + Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. + GOC:TermGenie + GO_REF:0000058 + PMID:22674394 + @@ -91518,8 +134158,18 @@ + Any process that modulates the frequency, rate or extent of bleb assembly. regulation of bleb assembly + + + + Any process that modulates the frequency, rate or extent of bleb assembly. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:25651887 + @@ -91545,8 +134195,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly. negative regulation of bleb assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:25651887 + @@ -91572,8 +134232,18 @@ + Any process that activates or increases the frequency, rate or extent of bleb assembly. positive regulation of bleb assembly + + + + Any process that activates or increases the frequency, rate or extent of bleb assembly. + GOC:TermGenie + GOC:als + GO_REF:0000058 + PMID:25651887 + @@ -91598,8 +134268,17 @@ + Any process that modulates the frequency, rate or extent of adipose tissue development. regulation of adipose tissue development + + + + Any process that modulates the frequency, rate or extent of adipose tissue development. + GOC:TermGenie + GO_REF:0000058 + PMID:23081848 + @@ -91626,8 +134305,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. negative regulation of adipose tissue development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. + GOC:TermGenie + GO_REF:0000058 + PMID:23081848 + @@ -91654,8 +134342,124 @@ + Any process that activates or increases the frequency, rate or extent of adipose tissue development. positive regulation of adipose tissue development + + + + Any process that activates or increases the frequency, rate or extent of adipose tissue development. + GOC:TermGenie + GO_REF:0000058 + PMID:23081848 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process. + regulation of cholangiocyte apoptotic process + + + + + Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:24498161 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process. + negative regulation of cholangiocyte apoptotic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:24498161 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process. + positive regulation of cholangiocyte apoptotic process + + + + + Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:24498161 + @@ -91681,8 +134485,17 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy. regulation of skeletal muscle hypertrophy + + + + Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy. + GOC:TermGenie + GO_REF:0000058 + PMID:23470307 + @@ -91709,8 +134522,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy. negative regulation of skeletal muscle hypertrophy + + + + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy. + GOC:TermGenie + GO_REF:0000058 + PMID:23470307 + @@ -91737,8 +134559,17 @@ + Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy. positive regulation of skeletal muscle hypertrophy + + + + Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy. + GOC:TermGenie + GO_REF:0000058 + PMID:23470307 + @@ -91763,8 +134594,131 @@ + The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell. pericyte cell differentiation + + + + The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell. + GOC:TermGenie + GOC:dph + GO_REF:0000086 + PMID:23868830 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of bile acid metabolic process. + regulation of bile acid metabolic process + + + + + Any process that modulates the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. + negative regulation of bile acid metabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. + positive regulation of bile acid metabolic process + + + + + Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. + GOC:TermGenie + GOC:bf + GO_REF:0000058 + @@ -91789,8 +134743,232 @@ + The cell cortex of the leading edge of a cell. cell leading edge cell cortex + + + + The cell cortex of the leading edge of a cell. + GOC:TermGenie + GOC:kmv + GO_REF:0000064 + PMID:25843030 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + regulation of gastro-intestinal system smooth muscle contraction + + + + + Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:10821044 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + negative regulation of gastro-intestinal system smooth muscle contraction + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:10821044 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + positive regulation of gastro-intestinal system smooth muscle contraction + + + + + Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:10821044 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of colon smooth muscle contraction. + regulation of colon smooth muscle contraction + + + + + Any process that modulates the frequency, rate or extent of colon smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:24170253 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction. + negative regulation of colon smooth muscle contraction + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:24170253 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction. + positive regulation of colon smooth muscle contraction + + + + + Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:24170253 + @@ -91815,8 +134993,17 @@ + Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation. regulation of gastric mucosal blood circulation + + + + Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation. + GOC:TermGenie + GO_REF:0000058 + PMID:10807413 + @@ -91842,8 +135029,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation. negative regulation of gastric mucosal blood circulation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation. + GOC:TermGenie + GO_REF:0000058 + PMID:10807413 + @@ -91869,8 +135065,237 @@ + Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation. positive regulation of gastric mucosal blood circulation + + + + Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation. + GOC:TermGenie + GO_REF:0000058 + PMID:10807413 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction. + regulation of small intestine smooth muscle contraction + + + + + Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:11991626 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction. + negative regulation of small intestine smooth muscle contraction + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:11991626 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction. + positive regulation of small intestine smooth muscle contraction + + + + + Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction. + GOC:TermGenie + GO_REF:0000058 + PMID:11991626 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole. + regulation of protein catabolic process in the vacuole + + + + + Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:25635054 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole. + negative regulation of protein catabolic process in the vacuole + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:25635054 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole. + positive regulation of protein catabolic process in the vacuole + + + + + Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:25635054 + @@ -91895,8 +135320,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to cell periphery. regulation of protein localization to cell periphery + + + + Any process that modulates the frequency, rate or extent of protein localization to cell periphery. + GOC:TermGenie + GO_REF:0000058 + PMID:18216290 + @@ -91922,8 +135356,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. negative regulation of protein localization to cell periphery + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. + GOC:TermGenie + GO_REF:0000058 + PMID:18216290 + @@ -91949,8 +135392,17 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. positive regulation of protein localization to cell periphery + + + + Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. + GOC:TermGenie + GO_REF:0000058 + PMID:18216290 + @@ -91975,8 +135427,17 @@ + Any process that modulates the frequency, rate or extent of neuromuscular junction development. regulation of neuromuscular junction development + + + + Any process that modulates the frequency, rate or extent of neuromuscular junction development. + GOC:TermGenie + GO_REF:0000058 + PMID:7722643 + @@ -92002,8 +135463,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development. negative regulation of neuromuscular junction development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development. + GOC:TermGenie + GO_REF:0000058 + PMID:7722643 + @@ -92029,8 +135499,17 @@ + Any process that activates or increases the frequency, rate or extent of neuromuscular junction development. positive regulation of neuromuscular junction development + + + + Any process that activates or increases the frequency, rate or extent of neuromuscular junction development. + GOC:TermGenie + GO_REF:0000058 + PMID:7722643 + @@ -92055,8 +135534,17 @@ + Any process that modulates the frequency, rate or extent of secretory granule organization. regulation of secretory granule organization + + + + Any process that modulates the frequency, rate or extent of secretory granule organization. + GOC:TermGenie + GO_REF:0000058 + PMID:15039777 + @@ -92082,8 +135570,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization. negative regulation of secretory granule organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization. + GOC:TermGenie + GO_REF:0000058 + PMID:15039777 + @@ -92109,8 +135606,17 @@ + Any process that activates or increases the frequency, rate or extent of secretory granule organization. positive regulation of secretory granule organization + + + + Any process that activates or increases the frequency, rate or extent of secretory granule organization. + GOC:TermGenie + GO_REF:0000058 + PMID:15039777 + @@ -92135,8 +135641,17 @@ + Any process that modulates the frequency, rate or extent of cardiac ventricle development. regulation of cardiac ventricle development + + + + Any process that modulates the frequency, rate or extent of cardiac ventricle development. + GOC:TermGenie + GO_REF:0000058 + PMID:19590510 + @@ -92163,8 +135678,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development. negative regulation of cardiac ventricle development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development. + GOC:TermGenie + GO_REF:0000058 + PMID:19590510 + @@ -92191,8 +135715,17 @@ + Any process that activates or increases the frequency, rate or extent of cardiac ventricle development. positive regulation of cardiac ventricle development + + + + Any process that activates or increases the frequency, rate or extent of cardiac ventricle development. + GOC:TermGenie + GO_REF:0000058 + PMID:19590510 + @@ -92219,8 +135752,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. negative regulation of neuronal action potential + + + + Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. + GOC:TermGenie + GO_REF:0000058 + PMID:25126967 + @@ -92247,8 +135789,53 @@ + Any process that activates or increases the frequency, rate or extent of neuronal action potential. positive regulation of neuronal action potential + + + + Any process that activates or increases the frequency, rate or extent of neuronal action potential. + GOC:TermGenie + GO_REF:0000058 + PMID:25126967 + + + + + + + + + + + + + + + + + + + + + + + + + + The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure. + cloacal gland development + + + + + The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure. + GOC:TermGenie + GOC:mr + GO_REF:0000094 + PMID:18805421 + @@ -92273,8 +135860,18 @@ + A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone. protein localization to ciliary transition zone + + + + A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone. + GOC:TermGenie + GOC:kmv + GO_REF:0000087 + PMID:21422230 + @@ -92299,8 +135896,17 @@ + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. response to glycoprotein + + + + Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:14597422 + @@ -92320,8 +135926,17 @@ + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. cellular response to glycoprotein + + + + Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. + GOC:TermGenie + GO_REF:0000071 + PMID:14597422 + @@ -92346,8 +135961,17 @@ + Any apoptotic process in a fat cell. fat cell apoptotic process + + + + Any apoptotic process in a fat cell. + GOC:TermGenie + GO_REF:0000085 + PMID:17024416 + @@ -92372,8 +135996,17 @@ + Any process that modulates the frequency, rate or extent of fat cell apoptotic process. regulation of fat cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of fat cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:17024416 + @@ -92399,8 +136032,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process. negative regulation of fat cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:17024416 + @@ -92426,8 +136068,17 @@ + Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process. positive regulation of fat cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process. + GOC:TermGenie + GO_REF:0000058 + PMID:17024416 + @@ -92452,8 +136103,17 @@ + Any process that modulates the frequency, rate or extent of lung alveolus development. regulation of lung alveolus development + + + + Any process that modulates the frequency, rate or extent of lung alveolus development. + GOC:TermGenie + GO_REF:0000058 + PMID:23962064 + @@ -92480,8 +136140,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development. negative regulation of lung alveolus development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development. + GOC:TermGenie + GO_REF:0000058 + PMID:23962064 + @@ -92508,8 +136177,56 @@ + Any process that activates or increases the frequency, rate or extent of lung alveolus development. positive regulation of lung alveolus development + + + + Any process that activates or increases the frequency, rate or extent of lung alveolus development. + GOC:TermGenie + GO_REF:0000058 + PMID:23962064 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which glucose is transported across a membrane. + glucose transmembrane transport + + + + + The process in which glucose is transported across a membrane. + GOC:TermGenie + GO_REF:0000069 + PMID:9090050 + @@ -92534,8 +136251,20 @@ + Any process that modulates the frequency, rate or extent of somatic stem cell division. regulation of somatic stem cell division + + + + Any process that modulates the frequency, rate or extent of somatic stem cell division. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19409607 + @@ -92561,8 +136290,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division. negative regulation of somatic stem cell division + + + + Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19409607 + @@ -92588,8 +136329,138 @@ + Any process that activates or increases the frequency, rate or extent of somatic stem cell division. positive regulation of somatic stem cell division + + + + Any process that activates or increases the frequency, rate or extent of somatic stem cell division. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19409607 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Enables the transfer of a peptide from one side of a membrane to the other. + Reactome:R-HSA-1500817 + peptide transmembrane transporter activity + + + + + Enables the transfer of a peptide from one side of a membrane to the other. + GOC:TermGenie + GOC:vw + GO_REF:0000070 + + + + + Reactome:R-HSA-1500817 + Glutathione is taken up by the bacterium + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation. + negative regulation of type B pancreatic cell proliferation + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24055447 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation. + positive regulation of type B pancreatic cell proliferation + + + + + Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:24055447 + @@ -92626,8 +136497,126 @@ + The developmental process by which a midbrain is generated and organized. midbrain morphogenesis + + + + The developmental process by which a midbrain is generated and organized. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000083 + PMID:21347250 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of acinar cell proliferation. + regulation of acinar cell proliferation + + + + + Any process that modulates the frequency, rate or extent of acinar cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:9788538 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation. + negative regulation of acinar cell proliferation + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:9788538 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of acinar cell proliferation. + positive regulation of acinar cell proliferation + + + + + Any process that activates or increases the frequency, rate or extent of acinar cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:9788538 + @@ -92652,8 +136641,17 @@ + Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation. regulation of vascular associated smooth muscle cell proliferation + + + + Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:23246467 + @@ -92679,8 +136677,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. negative regulation of vascular associated smooth muscle cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:23246467 + @@ -92706,8 +136713,17 @@ + Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. positive regulation of vascular associated smooth muscle cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:23246467 + @@ -92732,8 +136748,20 @@ + The orderly movement of a vascular associated smooth muscle cell from one site to another. vascular associated smooth muscle cell migration + + + + The orderly movement of a vascular associated smooth muscle cell from one site to another. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000091 + PMID:20693317 + @@ -92760,8 +136788,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development. + U4PR86 in PMID:22801495 inferred from mutant phenotype negative regulation of apoptotic process involved in development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development. + GOC:TermGenie + GO_REF:0000058 + PMID:22801495 + @@ -92788,8 +136826,18 @@ + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. + U4PR86 in PMID:22801495 inferred from mutant phenotype positive regulation of apoptotic process involved in development + + + + Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. + GOC:TermGenie + GO_REF:0000058 + PMID:22801495 + @@ -92815,8 +136863,18 @@ + Any process that modulates the frequency, rate or extent of apoptotic process involved in development. + Q10943 in PMID:22801495, inferred from mutant phenotype regulation of apoptotic process involved in development + + + + Any process that modulates the frequency, rate or extent of apoptotic process involved in development. + GOC:TermGenie + GO_REF:0000058 + PMID:22801495 + @@ -92841,8 +136899,20 @@ + Any process that modulates the frequency, rate or extent of protein localization to nucleolus. regulation of protein localization to nucleolus + + + + Any process that modulates the frequency, rate or extent of protein localization to nucleolus. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:24415760 + @@ -92868,8 +136938,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus. negative regulation of protein localization to nucleolus + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:24415760 + @@ -92895,8 +136977,20 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus. positive regulation of protein localization to nucleolus + + + + Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:24415760 + @@ -92921,8 +137015,20 @@ + Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration. regulation of vascular associated smooth muscle cell migration + + + + Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:20693317 + @@ -92948,8 +137054,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration. negative regulation of vascular associated smooth muscle cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:20693317 + @@ -92975,8 +137093,20 @@ + Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration. positive regulation of vascular associated smooth muscle cell migration + + + + Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:20693317 + @@ -93001,8 +137131,17 @@ + The developmental process by which an intramembranous bone is generated and organized. intramembranous bone morphogenesis + + + + The developmental process by which an intramembranous bone is generated and organized. + GOC:TermGenie + GO_REF:0000083 + PMID:26399686 + @@ -93027,8 +137166,18 @@ + Any process that modulates the frequency, rate or extent of protein localization to cell cortex. + An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. regulation of protein localization to cell cortex + + + + Any process that modulates the frequency, rate or extent of protein localization to cell cortex. + GOC:TermGenie + GO_REF:0000058 + PMID:17115027 + @@ -93054,8 +137203,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex. + An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. negative regulation of protein localization to cell cortex + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex. + GOC:TermGenie + GO_REF:0000058 + PMID:17115027 + @@ -93081,8 +137240,18 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex. + An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. positive regulation of protein localization to cell cortex + + + + Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex. + GOC:TermGenie + GO_REF:0000058 + PMID:17115027 + @@ -93107,8 +137276,18 @@ + The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure. serous membrane development + + + + The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure. + GOC:TermGenie + GOC:dph + GO_REF:0000094 + PMID:15840053 + @@ -93139,8 +137318,18 @@ + The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure. visceral peritoneum development + + + + The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure. + GOC:TermGenie + GOC:dph + GO_REF:0000094 + PMID:15840053 + @@ -93171,8 +137360,18 @@ + The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure. parietal peritoneum development + + + + The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure. + GOC:TermGenie + GOC:dph + GO_REF:0000094 + PMID:15840053 + @@ -93197,8 +137396,18 @@ + The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure. peritoneum development + + + + The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure. + GOC:TermGenie + GOC:dph + GO_REF:0000094 + PMID:15840053 + @@ -93223,8 +137432,20 @@ + Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation. regulation of aortic smooth muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22034194 + @@ -93250,8 +137471,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation. negative regulation of aortic smooth muscle cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22034194 + @@ -93277,8 +137510,20 @@ + Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation. positive regulation of aortic smooth muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:22034194 + @@ -93303,8 +137548,19 @@ + The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. cranial skeletal system development + + + + The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000094 + PMID:11262227 + @@ -93329,8 +137585,20 @@ + Any process that modulates the frequency, rate or extent of cell proliferation in midbrain. regulation of cell proliferation in midbrain + + + + Any process that modulates the frequency, rate or extent of cell proliferation in midbrain. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:18953410 + PMID:24431302 + @@ -93356,8 +137624,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain. negative regulation of cell proliferation in midbrain + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:18953410 + PMID:24431302 + @@ -93383,8 +137663,19 @@ + Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain. positive regulation of cell proliferation in midbrain + + + + Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:24431302 + @@ -93409,8 +137700,18 @@ + The orderly movement of an interneuron from one site to another. interneuron migration + + + + The orderly movement of an interneuron from one site to another. + GOC:TermGenie + GOC:ah + GO_REF:0000091 + PMID:18622031 + @@ -93435,8 +137736,18 @@ + The orderly movement of a sensory neuron from one site to another. sensory neuron migration + + + + The orderly movement of a sensory neuron from one site to another. + GOC:TermGenie + GOC:ah + GO_REF:0000091 + PMID:18622031 + @@ -93461,8 +137772,20 @@ + Any process that modulates the frequency, rate or extent of cardiac ventricle formation. regulation of cardiac ventricle formation + + + + Any process that modulates the frequency, rate or extent of cardiac ventricle formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23575307 + @@ -93489,8 +137812,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation. negative regulation of cardiac ventricle formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23575307 + @@ -93516,8 +137851,20 @@ + Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation. positive regulation of cardiac ventricle formation + + + + Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23575307 + @@ -93543,8 +137890,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. negative regulation of establishment of protein localization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. + GOC:TermGenie + GO_REF:0000058 + PMID:22761445 + @@ -93570,8 +137926,17 @@ + Any process that activates or increases the frequency, rate or extent of establishment of protein localization. positive regulation of establishment of protein localization + + + + Any process that activates or increases the frequency, rate or extent of establishment of protein localization. + GOC:TermGenie + GO_REF:0000058 + PMID:22761445 + @@ -93596,8 +137961,20 @@ + Any process that modulates the frequency, rate or extent of endothelial cell activation. regulation of endothelial cell activation + + + + Any process that modulates the frequency, rate or extent of endothelial cell activation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:24255059 + @@ -93623,8 +138000,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation. negative regulation of endothelial cell activation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:24255059 + @@ -93650,8 +138039,54 @@ + Any process that activates or increases the frequency, rate or extent of endothelial cell activation. positive regulation of endothelial cell activation + + + + Any process that activates or increases the frequency, rate or extent of endothelial cell activation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:24255059 + + + + + + + + + + + + + + + + + + + + + + + + + The process in which carboxylic acid is transported across a membrane. + carboxylic acid transmembrane transport + + + + + The process in which carboxylic acid is transported across a membrane. + GOC:TermGenie + GO_REF:0000069 + PMID:10869563 + @@ -93676,8 +138111,20 @@ + Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation. regulation of vascular associated smooth muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19088079 + @@ -93703,8 +138150,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation. negative regulation of vascular associated smooth muscle cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19088079 + @@ -93730,8 +138189,20 @@ + Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation. positive regulation of vascular associated smooth muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:19088079 + @@ -93757,8 +138228,17 @@ + Any process that modulates the frequency, rate or extent of axo-dendritic protein transport. regulation of axo-dendritic protein transport + + + + Any process that modulates the frequency, rate or extent of axo-dendritic protein transport. + GOC:TermGenie + GO_REF:0000058 + PMID:20694152 + @@ -93784,8 +138264,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport. negative regulation of axo-dendritic protein transport + + + + Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport. + GOC:TermGenie + GO_REF:0000058 + PMID:20694152 + @@ -93811,8 +138300,17 @@ + Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport. positive regulation of axo-dendritic protein transport + + + + Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport. + GOC:TermGenie + GO_REF:0000058 + PMID:20694152 + @@ -93843,8 +138341,19 @@ + The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts. apical ectodermal ridge formation + + + + The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts. + GOC:TermGenie + GO_REF:0000081 + PMID:18359901 + PMID:9323126 + PMID:9596583 + @@ -93869,8 +138378,17 @@ + Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation. regulation of apical ectodermal ridge formation + + + + Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation. + GOC:TermGenie + GO_REF:0000058 + PMID:18359901 + @@ -93897,8 +138415,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation. negative regulation of apical ectodermal ridge formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation. + GOC:TermGenie + GO_REF:0000058 + PMID:18359901 + @@ -93925,8 +138452,55 @@ + Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation. positive regulation of apical ectodermal ridge formation + + + + Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation. + GOC:TermGenie + GO_REF:0000058 + PMID:18359901 + + + + + + + + + + + + + + + + + + + + + + + + + + Any cellular protein catabolic process that takes place in a lysosome. + Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants. + lysosomal protein catabolic process + + + + + Any cellular protein catabolic process that takes place in a lysosome. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000062 + PMID:24334770 + @@ -93952,8 +138526,20 @@ + Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy. regulation of smooth muscle hypertrophy + + + + Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:22161164 + @@ -93980,8 +138566,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy. negative regulation of smooth muscle hypertrophy + + + + Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:22161164 + @@ -94008,8 +138606,20 @@ + Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy. positive regulation of smooth muscle hypertrophy + + + + Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:22161164 + @@ -94034,8 +138644,19 @@ + Any process that modulates the frequency, rate or extent of membrane invagination. regulation of membrane invagination + + + + Any process that modulates the frequency, rate or extent of membrane invagination. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:26589353 + @@ -94061,8 +138682,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination. negative regulation of membrane invagination + + + + Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:26589353 + @@ -94088,8 +138720,129 @@ + Any process that activates or increases the frequency, rate or extent of membrane invagination. positive regulation of membrane invagination + + + + Any process that activates or increases the frequency, rate or extent of membrane invagination. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process. + regulation of lysosomal protein catabolic process + + + + + Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:23499937 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process. + negative regulation of lysosomal protein catabolic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process. + positive regulation of lysosomal protein catabolic process + + + + + Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + @@ -94114,8 +138867,20 @@ + Any process that modulates the frequency, rate or extent of cardiocyte differentiation. regulation of cardiocyte differentiation + + + + Any process that modulates the frequency, rate or extent of cardiocyte differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23069713 + @@ -94142,8 +138907,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. negative regulation of cardiocyte differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23069713 + @@ -94170,8 +138947,20 @@ + Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation. positive regulation of cardiocyte differentiation + + + + Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:23069713 + @@ -94198,8 +138987,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation. negative regulation of mitotic chromosome condensation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation. + GOC:TermGenie + GO_REF:0000058 + PMID:23219725 + @@ -94224,8 +139022,19 @@ + The developmental process by which an epicardium is generated and organized. epicardium morphogenesis + + + + The developmental process by which an epicardium is generated and organized. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000083 + PMID:18718461 + @@ -94251,8 +139060,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization. negative regulation of chromatin organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization. + GOC:TermGenie + GOC:pr + GOC:vw + GO_REF:0000058 + PMID:654321 + @@ -94278,8 +139098,19 @@ + Any process that activates or increases the frequency, rate or extent of chromatin organization. positive regulation of chromatin organization + + + + Any process that activates or increases the frequency, rate or extent of chromatin organization. + GOC:TermGenie + GOC:pr + GOC:vw + GO_REF:0000058 + PMID:654321 + @@ -94305,8 +139136,19 @@ + Any process that modulates the frequency, rate or extent of epithelial tube formation. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). regulation of epithelial tube formation + + + + Any process that modulates the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94333,8 +139175,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). negative regulation of epithelial tube formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94361,8 +139214,19 @@ + Any process that activates or increases the frequency, rate or extent of epithelial tube formation. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). positive regulation of epithelial tube formation + + + + Any process that activates or increases the frequency, rate or extent of epithelial tube formation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94387,8 +139251,20 @@ + Any apoptotic process in a vascular associated smooth muscle cell. vascular associated smooth muscle cell apoptotic process + + + + Any apoptotic process in a vascular associated smooth muscle cell. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000085 + PMID:26493107 + @@ -94413,8 +139289,19 @@ + Any process that modulates the frequency, rate or extent of neural crest cell differentiation. regulation of neural crest cell differentiation + + + + Any process that modulates the frequency, rate or extent of neural crest cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:15073157 + @@ -94441,8 +139328,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation. negative regulation of neural crest cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:15073157 + @@ -94469,8 +139367,139 @@ + Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation. positive regulation of neural crest cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:15073157 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of intestinal epithelial cell development. + regulation of intestinal epithelial cell development + + + + + Any process that modulates the frequency, rate or extent of intestinal epithelial cell development. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23904268 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development. + negative regulation of intestinal epithelial cell development + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23904268 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development. + positive regulation of intestinal epithelial cell development + + + + + Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23904268 + @@ -94497,8 +139526,19 @@ + Any process that modulates the frequency, rate or extent of cardiac myofibril assembly. regulation of cardiac myofibril assembly + + + + Any process that modulates the frequency, rate or extent of cardiac myofibril assembly. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:16151019 + @@ -94526,8 +139566,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly. negative regulation of cardiac myofibril assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:16151019 + @@ -94555,8 +139606,19 @@ + Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly. positive regulation of cardiac myofibril assembly + + + + Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:16151019 + @@ -94581,8 +139643,19 @@ + Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis + + + + Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:17628518 + @@ -94608,8 +139681,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:17628518 + @@ -94635,8 +139719,19 @@ + Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000058 + PMID:17628518 + @@ -94661,8 +139756,19 @@ + Any cell proliferation that is involved in endocardial cushion morphogenesis. cell proliferation involved in endocardial cushion morphogenesis + + + + Any cell proliferation that is involved in endocardial cushion morphogenesis. + GOC:BHF + GOC:TermGenie + GOC:rl + GO_REF:0000060 + PMID:20652948 + @@ -94687,8 +139793,18 @@ + The orderly movement of a mesenchymal stem cell from one site to another. mesenchymal stem cell migration + + + + The orderly movement of a mesenchymal stem cell from one site to another. + GOC:TermGenie + GO_REF:0000091 + PMID:24924806 + PMID:25181476 + @@ -94713,8 +139829,17 @@ + Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration. regulation of mesenchymal stem cell migration + + + + Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration. + GOC:TermGenie + GO_REF:0000058 + PMID:26846297 + @@ -94740,8 +139865,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration. negative regulation of mesenchymal stem cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration. + GOC:TermGenie + GO_REF:0000058 + PMID:26846297 + @@ -94767,8 +139901,17 @@ + Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration. positive regulation of mesenchymal stem cell migration + + + + Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration. + GOC:TermGenie + GO_REF:0000058 + PMID:26846297 + @@ -94793,8 +139936,19 @@ + Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). regulation of morphogenesis of an epithelium + + + + Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94820,8 +139974,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). negative regulation of morphogenesis of an epithelium + + + + Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94847,8 +140012,19 @@ + Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. + An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). positive regulation of morphogenesis of an epithelium + + + + Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:25745997 + @@ -94879,8 +140055,22 @@ + The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone. ciliary transition zone assembly + + + + The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone. + GOC:TermGenie + GOC:cilia + GO_REF:0000079 + PMID:21725307 + PMID:23644468 + PMID:24448408 + PMID:26595381 + PMID:26982032 + @@ -94905,8 +140095,20 @@ + The orderly movement of a pericyte cell from one site to another. pericyte cell migration + + + + The orderly movement of a pericyte cell from one site to another. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000091 + PMID:26268439 + @@ -94931,8 +140133,17 @@ + A process in which a protein is transported to, or maintained in, a location within a presynapse. protein localization to presynapse + + + + A process in which a protein is transported to, or maintained in, a location within a presynapse. + GOC:TermGenie + GO_REF:0000087 + PMID:24449494 + @@ -94957,8 +140168,19 @@ + Any process that modulates the frequency, rate or extent of protein localization to presynapse. regulation of protein localization to presynapse + + + + Any process that modulates the frequency, rate or extent of protein localization to presynapse. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:24449494 + @@ -94984,8 +140206,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse. negative regulation of protein localization to presynapse + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:24449494 + @@ -95011,8 +140244,19 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to presynapse. positive regulation of protein localization to presynapse + + + + Any process that activates or increases the frequency, rate or extent of protein localization to presynapse. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:24449494 + @@ -95037,8 +140281,19 @@ + Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. regulation of retrograde trans-synaptic signaling by neuropeptide + + + + Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:19448629 + @@ -95065,8 +140320,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. negative regulation of retrograde trans-synaptic signaling by neuropeptide + + + + Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:19448629 + @@ -95093,8 +140359,19 @@ + Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. positive regulation of retrograde trans-synaptic signaling by neuropeptide + + + + Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. + GOC:PARL + GOC:TermGenie + GOC:bf + GO_REF:0000058 + PMID:19448629 + @@ -95119,8 +140396,17 @@ + Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation. regulation of myeloid progenitor cell differentiation + + + + Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95146,8 +140432,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation. negative regulation of myeloid progenitor cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95173,8 +140468,17 @@ + Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation. positive regulation of myeloid progenitor cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95199,8 +140503,17 @@ + Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation. regulation of lymphoid progenitor cell differentiation + + + + Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95226,8 +140539,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation. negative regulation of lymphoid progenitor cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95253,8 +140575,17 @@ + Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation. positive regulation of lymphoid progenitor cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation. + GOC:TermGenie + GO_REF:0000058 + PMID:27010503 + @@ -95279,8 +140610,20 @@ + Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. regulation of vascular associated smooth muscle cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:26493107 + @@ -95306,8 +140649,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. negative regulation of vascular associated smooth muscle cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:26493107 + @@ -95333,8 +140688,20 @@ + Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. positive regulation of vascular associated smooth muscle cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:26493107 + @@ -95359,8 +140726,19 @@ + Any process that modulates the frequency, rate or extent of protein localization to membrane. regulation of protein localization to membrane + + + + Any process that modulates the frequency, rate or extent of protein localization to membrane. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:26911690 + @@ -95386,8 +140764,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane. negative regulation of protein localization to membrane + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:26911690 + @@ -95413,8 +140802,19 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to membrane. positive regulation of protein localization to membrane + + + + Any process that activates or increases the frequency, rate or extent of protein localization to membrane. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:26911690 + @@ -95439,8 +140839,17 @@ + Any process that modulates the frequency, rate or extent of motor neuron migration. regulation of motor neuron migration + + + + Any process that modulates the frequency, rate or extent of motor neuron migration. + GOC:TermGenie + GO_REF:0000058 + PMID:16516839 + @@ -95466,8 +140875,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration. negative regulation of motor neuron migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration. + GOC:TermGenie + GO_REF:0000058 + PMID:16516839 + @@ -95493,8 +140911,17 @@ + Any process that activates or increases the frequency, rate or extent of motor neuron migration. positive regulation of motor neuron migration + + + + Any process that activates or increases the frequency, rate or extent of motor neuron migration. + GOC:TermGenie + GO_REF:0000058 + PMID:16516839 + @@ -95521,8 +140948,17 @@ + Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve. positive regulation of branching morphogenesis of a nerve + + + + Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve. + GOC:TermGenie + GO_REF:0000058 + PMID:16516839 + @@ -95547,8 +140983,19 @@ + Any process that modulates the frequency, rate or extent of motile cilium assembly. regulation of motile cilium assembly + + + + Any process that modulates the frequency, rate or extent of motile cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:25294941 + @@ -95574,8 +141021,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly. negative regulation of motile cilium assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:25294941 + @@ -95601,8 +141059,19 @@ + Any process that activates or increases the frequency, rate or extent of motile cilium assembly. positive regulation of motile cilium assembly + + + + Any process that activates or increases the frequency, rate or extent of motile cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:25294941 + @@ -95628,8 +141097,18 @@ + Any process that activates or increases the frequency, rate or extent of fertilization. positive regulation of fertilization + + + + Any process that activates or increases the frequency, rate or extent of fertilization. + GOC:TermGenie + GOC:hbye + GO_REF:0000058 + PMID:27564576 + @@ -95655,8 +141134,17 @@ + The orderly movement of a macrophage from one site to another. macrophage migration + + + + The orderly movement of a macrophage from one site to another. + GOC:TermGenie + GO_REF:0000091 + PMID:25749876 + @@ -95681,8 +141169,17 @@ + Any process that modulates the frequency, rate or extent of macrophage migration. regulation of macrophage migration + + + + Any process that modulates the frequency, rate or extent of macrophage migration. + GOC:TermGenie + GO_REF:0000058 + PMID:25749876 + @@ -95708,8 +141205,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration. negative regulation of macrophage migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration. + GOC:TermGenie + GO_REF:0000058 + PMID:25749876 + @@ -95735,8 +141241,17 @@ + Any process that activates or increases the frequency, rate or extent of macrophage migration. positive regulation of macrophage migration + + + + Any process that activates or increases the frequency, rate or extent of macrophage migration. + GOC:TermGenie + GO_REF:0000058 + PMID:25749876 + @@ -95763,8 +141278,20 @@ + Any process that modulates the frequency, rate or extent of blood vessel branching. regulation of blood vessel branching + + + + Any process that modulates the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -95791,8 +141318,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. negative regulation of vessel branching + + + + Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -95819,8 +141358,20 @@ + Any process that activates or increases the frequency, rate or extent of blood vessel branching. positive regulation of blood vessel branching + + + + Any process that activates or increases the frequency, rate or extent of blood vessel branching. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -95846,8 +141397,17 @@ + Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly. regulation of mitotic nuclear envelope disassembly + + + + Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly. + GOC:TermGenie + GO_REF:0000058 + PMID:18765790 + @@ -95874,8 +141434,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly. negative regulation of mitotic nuclear envelope disassembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly. + GOC:TermGenie + GO_REF:0000058 + PMID:18765790 + @@ -95902,8 +141471,17 @@ + Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly. positive regulation of mitotic nuclear envelope disassembly + + + + Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly. + GOC:TermGenie + GO_REF:0000058 + PMID:18765790 + @@ -95928,8 +141506,20 @@ + Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation. regulation of vascular endothelial cell proliferation + + + + Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -95955,8 +141545,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. negative regulation of vascular endothelial cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -95982,8 +141584,20 @@ + Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. positive regulation of vascular endothelial cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. + GOC:BHF + GOC:BHF_telomere + GOC:TermGenie + GOC:nc + GO_REF:0000058 + PMID:23201774 + @@ -96008,8 +141622,19 @@ + Any process that modulates the frequency, rate or extent of presynapse assembly. regulation of presynapse assembly + + + + Any process that modulates the frequency, rate or extent of presynapse assembly. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:25533483 + @@ -96035,8 +141660,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly. negative regulation of presynapse assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:25533483 + @@ -96062,8 +141698,19 @@ + Any process that activates or increases the frequency, rate or extent of presynapse assembly. positive regulation of presynapse assembly + + + + Any process that activates or increases the frequency, rate or extent of presynapse assembly. + GOC:PARL + GOC:TermGenie + GOC:bc + GO_REF:0000058 + PMID:25533483 + @@ -96088,8 +141735,19 @@ + Any process that modulates the frequency, rate or extent of serotonin biosynthetic process. regulation of serotonin biosynthetic process + + + + Any process that modulates the frequency, rate or extent of serotonin biosynthetic process. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:25642596 + @@ -96115,8 +141773,19 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process. negative regulation of serotonin biosynthetic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:25642596 + @@ -96142,8 +141811,19 @@ + Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process. positive regulation of serotonin biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process. + GOC:PARL + GOC:TermGenie + GOC:pad + GO_REF:0000058 + PMID:25642596 + @@ -96168,8 +141848,17 @@ + A process in which a protein is transported to, or maintained in, a location within an euchromatin. protein localization to euchromatin + + + + A process in which a protein is transported to, or maintained in, a location within an euchromatin. + GOC:TermGenie + GO_REF:0000087 + PMID:20889714 + @@ -96189,8 +141878,17 @@ + The directed movement of a protein to a specific location in an euchromatin. establishment of protein localization to euchromatin + + + + The directed movement of a protein to a specific location in an euchromatin. + GOC:TermGenie + GO_REF:0000087 + PMID:20889714 + @@ -96215,8 +141913,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to chromatin. regulation of protein localization to chromatin + + + + Any process that modulates the frequency, rate or extent of protein localization to chromatin. + GOC:TermGenie + GO_REF:0000058 + PMID:20889714 + @@ -96241,8 +141948,20 @@ + Any process that modulates the frequency, rate or extent of artery morphogenesis. regulation of artery morphogenesis + + + + Any process that modulates the frequency, rate or extent of artery morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:27389411 + @@ -96268,8 +141987,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis. negative regulation of artery morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:27389411 + @@ -96295,8 +142026,20 @@ + Any process that activates or increases the frequency, rate or extent of artery morphogenesis. positive regulation of artery morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of artery morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:27389411 + @@ -96321,8 +142064,17 @@ + Any process that modulates the frequency, rate or extent of lysosome organization. regulation of lysosome organization + + + + Any process that modulates the frequency, rate or extent of lysosome organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25561470 + @@ -96348,8 +142100,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization. negative regulation of lysosome organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25561470 + @@ -96375,8 +142136,17 @@ + Any process that activates or increases the frequency, rate or extent of lysosome organization. positive regulation of lysosome organization + + + + Any process that activates or increases the frequency, rate or extent of lysosome organization. + GOC:TermGenie + GO_REF:0000058 + PMID:25561470 + @@ -96401,8 +142171,18 @@ + The disaggregation of a nucleus into its constituent components. nucleus disassembly + + + + The disaggregation of a nucleus into its constituent components. + GOC:TermGenie + GOC:autophagy + GOC:pr + GO_REF:0000079 + @@ -96427,8 +142207,18 @@ + Any microtubule bundle that is part of a cytoplasm. cytoplasmic microtubule bundle + + + + Any microtubule bundle that is part of a cytoplasm. + GOC:TermGenie + GO_REF:0000064 + PMID:11007487 + PMID:26124291 + @@ -96453,8 +142243,17 @@ + A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule. protein localization to cytoplasmic microtubule + + + + A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule. + GOC:TermGenie + GO_REF:0000087 + PMID:15177031 + @@ -96479,8 +142278,20 @@ + Any process that modulates the frequency, rate or extent of mesodermal cell differentiation. regulation of mesodermal cell differentiation + + + + Any process that modulates the frequency, rate or extent of mesodermal cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23765923 + @@ -96506,8 +142317,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation. negative regulation of mesodermal cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23765923 + @@ -96533,8 +142356,20 @@ + Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation. positive regulation of mesodermal cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23765923 + @@ -96559,8 +142394,17 @@ + Any process that modulates the frequency, rate or extent of synapse pruning. regulation of synapse pruning + + + + Any process that modulates the frequency, rate or extent of synapse pruning. + GOC:TermGenie + GO_REF:0000058 + PMID:27779093 + @@ -96586,8 +142430,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning. negative regulation of synapse pruning + + + + Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning. + GOC:TermGenie + GO_REF:0000058 + PMID:27779093 + @@ -96613,8 +142466,17 @@ + Any process that activates or increases the frequency, rate or extent of synapse pruning. positive regulation of synapse pruning + + + + Any process that activates or increases the frequency, rate or extent of synapse pruning. + GOC:TermGenie + GO_REF:0000058 + PMID:27779093 + @@ -96640,8 +142502,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization. negative regulation of synapse organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization. + GOC:TermGenie + GO_REF:0000058 + PMID:27779093 + @@ -96667,8 +142538,18 @@ + Any process that activates or increases the frequency, rate or extent of chromosome condensation. positive regulation of chromosome condensation + + + + Any process that activates or increases the frequency, rate or extent of chromosome condensation. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:17268547 + @@ -96694,8 +142575,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation. negative regulation of microtubule nucleation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation. + GOC:TermGenie + GO_REF:0000058 + PMID:27689799 + @@ -96720,8 +142610,17 @@ + Any process that modulates the frequency, rate or extent of protein localization to cell leading edge. regulation of protein localization to cell leading edge + + + + Any process that modulates the frequency, rate or extent of protein localization to cell leading edge. + GOC:TermGenie + GO_REF:0000058 + PMID:26324884 + @@ -96747,8 +142646,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge. negative regulation of protein localization to cell leading edge + + + + Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge. + GOC:TermGenie + GO_REF:0000058 + PMID:26324884 + @@ -96774,8 +142682,17 @@ + Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge. positive regulation of protein localization to cell leading edge + + + + Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge. + GOC:TermGenie + GO_REF:0000058 + PMID:26324884 + @@ -96802,8 +142719,17 @@ + Any process that modulates the frequency, rate or extent of oogenesis. regulation of oogenesis + + + + Any process that modulates the frequency, rate or extent of oogenesis. + GOC:TermGenie + GO_REF:0000058 + PMID:26434723 + @@ -96831,8 +142757,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. negative regulation of oogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. + GOC:TermGenie + GO_REF:0000058 + PMID:26434723 + @@ -96860,8 +142795,17 @@ + Any process that activates or increases the frequency, rate or extent of oogenesis. positive regulation of oogenesis + + + + Any process that activates or increases the frequency, rate or extent of oogenesis. + GOC:TermGenie + GO_REF:0000058 + PMID:26434723 + @@ -96886,8 +142830,18 @@ + Any process that modulates the frequency, rate or extent of smooth muscle tissue development. regulation of smooth muscle tissue development + + + + Any process that modulates the frequency, rate or extent of smooth muscle tissue development. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:14709716 + @@ -96913,8 +142867,18 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development. negative regulation of smooth muscle tissue development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:14709716 + @@ -96940,8 +142904,18 @@ + Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development. positive regulation of smooth muscle tissue development + + + + Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development. + GOC:TermGenie + GOC:bhm + GO_REF:0000058 + PMID:14709716 + @@ -96966,8 +142940,20 @@ + Any process that modulates the frequency, rate or extent of mesoderm formation. regulation of mesoderm formation + + + + Any process that modulates the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 + @@ -96993,8 +142979,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. negative regulation of mesoderm formation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 + @@ -97020,8 +143018,20 @@ + Any process that activates or increases the frequency, rate or extent of mesoderm formation. positive regulation of mesoderm formation + + + + Any process that activates or increases the frequency, rate or extent of mesoderm formation. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:23939491 + @@ -97047,8 +143057,17 @@ + Any process that modulates the frequency, rate or extent of germ cell proliferation. regulation of germ cell proliferation + + + + Any process that modulates the frequency, rate or extent of germ cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97075,8 +143094,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation. negative regulation of germ cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97103,8 +143131,17 @@ + Any process that activates or increases the frequency, rate or extent of germ cell proliferation. positive regulation of germ cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of germ cell proliferation. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97130,8 +143167,17 @@ + Any process that modulates the frequency, rate or extent of gonad development. regulation of gonad development + + + + Any process that modulates the frequency, rate or extent of gonad development. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97159,8 +143205,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. negative regulation of gonad development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97188,8 +143243,17 @@ + Any process that activates or increases the frequency, rate or extent of gonad development. positive regulation of gonad development + + + + Any process that activates or increases the frequency, rate or extent of gonad development. + GOC:TermGenie + GO_REF:0000058 + PMID:15342467 + @@ -97214,8 +143278,17 @@ + Any process that modulates the frequency, rate or extent of lipid localization. regulation of lipid localization + + + + Any process that modulates the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 + @@ -97241,8 +143314,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. negative regulation of lipid localization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 + @@ -97268,8 +143350,17 @@ + Any process that activates or increases the frequency, rate or extent of lipid localization. positive regulation of lipid localization + + + + Any process that activates or increases the frequency, rate or extent of lipid localization. + GOC:TermGenie + GO_REF:0000058 + PMID:17564681 + @@ -97296,8 +143387,20 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis. negative regulation of endothelial tube morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:25961718 + @@ -97324,8 +143427,20 @@ + Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis. positive regulation of endothelial tube morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis. + GOC:BHF + GOC:BHF_miRNA + GOC:TermGenie + GOC:rph + GO_REF:0000058 + PMID:25961718 + @@ -97350,8 +143465,17 @@ + Any apoptotic process in a retinal cell. retinal cell apoptotic process + + + + Any apoptotic process in a retinal cell. + GOC:mtg_apoptosis + PMID:15558487 + PMID:24664675 + @@ -97376,8 +143500,16 @@ + Any apoptotic process in a compound eye retinal cell. compound eye retinal cell apoptotic process + + + + Any apoptotic process in a compound eye retinal cell. + GOC:mtg_apoptosis + PMID:12021768 + @@ -97435,8 +143567,19 @@ + The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. exosomal secretion + + + + The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. + GOC:hjd + PMID:10572093 + PMID:12154376 + PMID:16773132 + PMID:18617898 + @@ -97461,8 +143604,52 @@ + A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin. RNA localization to chromatin + + + + A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin. + GOC:dos + GOC:mah + PMID:22582262 + + + + + + + + + + + + + + + + + + + + + + + + + + A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. + An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). + transporter complex + + + + + A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. + GOC:bhm + PMID:15449578 + @@ -97487,8 +143674,140 @@ + Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis. dense core granule maturation + + + + Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis. + GOC:kmv + PMID:22654674 + + + + + + + + + + + + + + + + + + + + + + + + + + The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. + cholangiocyte proliferation + + + + + The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. + PMID:24434010 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. + cellular detoxification + + + + + Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. + GOC:vw + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum. + colon smooth muscle contraction + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum. + PMID:24170253 + @@ -97513,8 +143832,66 @@ + The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. gastric mucosal blood circulation + + + + The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. + PMID:10807413 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. + small intestine smooth muscle contraction + + + + + A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. + PMID:11991626 + @@ -97539,8 +143916,15 @@ + A process in which a protein is transported to, or maintained in, the cell periphery. protein localization to cell periphery + + + + A process in which a protein is transported to, or maintained in, the cell periphery. + PMID:18216290 + @@ -97565,8 +143949,48 @@ + Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell. vacuolar localization + + + + Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell. + PMID:26283797 + + + + + + + + + + + + + + + + + + + + + + + + + + The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus). + acinar cell proliferation + + + + + The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus). + PMID:9788538 + @@ -97591,8 +144015,15 @@ + The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. vascular associated smooth muscle cell proliferation + + + + The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. + PMID:23246467 + @@ -97606,8 +144037,17 @@ + A macromolecular complex that contains both RNA and protein molecules. + Wikipedia:Ribonucleoprotein ribonucleoprotein complex + + + + A macromolecular complex that contains both RNA and protein molecules. + GOC:krc + GOC:vesicles + @@ -97658,8 +144098,15 @@ + The cytoplasm of an ovum. ooplasm + + + + The cytoplasm of an ovum. + PMID:19022436 + @@ -97685,8 +144132,15 @@ + Any process that modulates the frequency, rate or extent of multicellular organismal development. regulation of multicellular organismal development + + + + Any process that modulates the frequency, rate or extent of multicellular organismal development. + GOC:obol + @@ -97711,8 +144165,15 @@ + Any process that modulates the frequency, rate or extent of animal organ morphogenesis. regulation of animal organ morphogenesis + + + + Any process that modulates the frequency, rate or extent of animal organ morphogenesis. + GOC:obol + @@ -97737,8 +144198,15 @@ + Any process that modulates the frequency, rate or extent of stem cell division. regulation of stem cell division + + + + Any process that modulates the frequency, rate or extent of stem cell division. + GOC:obol + @@ -97763,8 +144231,122 @@ + Any process that modulates the frequency, rate or extent of defense response to insect. regulation of defense response to insect + + + + Any process that modulates the frequency, rate or extent of defense response to insect. + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of pancreatic B cell development. + regulation of type B pancreatic cell development + + + + + Any process that modulates the frequency, rate or extent of pancreatic B cell development. + GOC:obol + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. + negative regulation of type B pancreatic cell development + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. + GOC:obol + GOC:yaf + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. + positive regulation of type B pancreatic cell development + + + + + Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. + GOC:obol + GOC:yaf + @@ -97789,8 +144371,16 @@ + Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. regulation of leukocyte apoptotic process + + + + Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97816,8 +144406,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. negative regulation of leukocyte apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97843,8 +144441,16 @@ + Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. positive regulation of leukocyte apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97870,8 +144476,16 @@ + Any process that modulates the frequency, rate or extent of macrophage apoptotic process. regulation of macrophage apoptotic process + + + + Any process that modulates the frequency, rate or extent of macrophage apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97898,8 +144512,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process. negative regulation of macrophage apoptotic process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97926,8 +144548,16 @@ + Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process. positive regulation of macrophage apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process. + GOC:BHF + GOC:mtg_apoptosis + @@ -97952,8 +144582,15 @@ + Any process that modulates the frequency, rate or extent of establishment of cell polarity. regulation of establishment of cell polarity + + + + Any process that modulates the frequency, rate or extent of establishment of cell polarity. + GOC:dph + @@ -97978,8 +144615,15 @@ + Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. regulation of cell proliferation involved in heart morphogenesis + + + + Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. + GOC:dph + @@ -98005,8 +144649,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis. negative regulation of cell proliferation involved in heart morphogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis. + GOC:dph + @@ -98032,8 +144683,15 @@ + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. positive regulation of cell proliferation involved in heart morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. + GOC:dph + @@ -98059,8 +144717,15 @@ + Any process that modulates the frequency, rate or extent of cell motility. regulation of cell motility + + + + Any process that modulates the frequency, rate or extent of cell motility. + GOC:mah + @@ -98087,8 +144752,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. negative regulation of cell motility + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. + GOC:mah + @@ -98115,8 +144787,15 @@ + Any process that activates or increases the frequency, rate or extent of cell motility. positive regulation of cell motility + + + + Any process that activates or increases the frequency, rate or extent of cell motility. + GOC:mah + @@ -98142,8 +144821,16 @@ + Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility. positive regulation of cilium-dependent cell motility + + + + Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility. + GOC:cilia + GOC:jl + @@ -98168,8 +144855,15 @@ + Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve. regulation of branching morphogenesis of a nerve + + + + Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve. + GOC:BHF + @@ -98196,8 +144890,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve. negative regulation of branching morphogenesis of a nerve + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve. + GOC:BHF + @@ -98223,8 +144924,15 @@ + Any process that modulates the frequency, rate or extent of pro-T cell differentiation. regulation of pro-T cell differentiation + + + + Any process that modulates the frequency, rate or extent of pro-T cell differentiation. + GOC:BHF + @@ -98251,8 +144959,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation. negative regulation of pro-T cell differentiation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation. + GOC:BHF + @@ -98279,8 +144994,15 @@ + Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation. positive regulation of pro-T cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation. + GOC:BHF + @@ -98305,8 +145027,16 @@ + Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. regulation of neural precursor cell proliferation + + + + Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. + GOC:dph + GOC:yaf + @@ -98332,8 +145062,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. negative regulation of neural precursor cell proliferation + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. + GOC:dph + GOC:yaf + @@ -98359,8 +145097,16 @@ + Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. positive regulation of neural precursor cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. + GOC:dph + GOC:yaf + @@ -98386,8 +145132,16 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. negative regulation of blood vessel morphogenesis + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. + GOC:dph + GOC:yaf + @@ -98413,8 +145167,15 @@ + Any process that modulates the frequency, rate or extent of female gonad development. regulation of female gonad development + + + + Any process that modulates the frequency, rate or extent of female gonad development. + GOC:obol + @@ -98440,8 +145201,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. negative regulation of female gonad development + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. + GOC:obol + @@ -98467,8 +145235,118 @@ + Any process that activates or increases the frequency, rate or extent of female gonad development. positive regulation of female gonad development + + + + Any process that activates or increases the frequency, rate or extent of female gonad development. + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation. + regulation of pancreatic A cell differentiation + + + + + Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation. + negative regulation of pancreatic A cell differentiation + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation. + positive regulation of pancreatic A cell differentiation + + + + + Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation. + GOC:mah + @@ -98493,8 +145371,15 @@ + Any process that modulates the frequency, rate or extent of reproductive process. regulation of reproductive process + + + + Any process that modulates the frequency, rate or extent of reproductive process. + GOC:mah + @@ -98520,8 +145405,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. negative regulation of reproductive process + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. + GOC:mah + @@ -98547,8 +145439,15 @@ + Any process that activates or increases the frequency, rate or extent of reproductive process. positive regulation of reproductive process + + + + Any process that activates or increases the frequency, rate or extent of reproductive process. + GOC:mah + @@ -98575,8 +145474,15 @@ + Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity. negative regulation of establishment or maintenance of neuroblast polarity + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity. + GOC:obol + @@ -98601,8 +145507,17 @@ + Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. regulation of fibroblast apoptotic process + + + + Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. + GOC:mtg_apoptosis + GOC:obol + GOC:yaf + @@ -98628,8 +145543,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. negative regulation of fibroblast apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. + GOC:mtg_apoptosis + GOC:obol + GOC:yaf + @@ -98655,8 +145579,17 @@ + Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process. positive regulation of fibroblast apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process. + GOC:mtg_apoptosis + GOC:obol + GOC:yaf + @@ -98681,8 +145614,15 @@ + Any process that modulates the frequency, rate or extent of DNA biosynthetic process. regulation of DNA biosynthetic process + + + + Any process that modulates the frequency, rate or extent of DNA biosynthetic process. + GOC:obol + @@ -98708,8 +145648,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. negative regulation of DNA biosynthetic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. + GOC:obol + @@ -98735,8 +145682,15 @@ + Any process that activates or increases the frequency, rate or extent of myotome development. positive regulation of myotome development + + + + Any process that activates or increases the frequency, rate or extent of myotome development. + GOC:BHF + @@ -98762,8 +145716,15 @@ + Any process that activates or increases the frequency, rate or extent of myoblast proliferation. positive regulation of myoblast proliferation + + + + Any process that activates or increases the frequency, rate or extent of myoblast proliferation. + GOC:BHF + @@ -98788,8 +145749,15 @@ + Any process that modulates the frequency, rate or extent of myotome development. regulation of myotome development + + + + Any process that modulates the frequency, rate or extent of myotome development. + GOC:mah + @@ -98814,8 +145782,119 @@ + Any process that modulates the frequency, rate or extent of myoblast proliferation. regulation of myoblast proliferation + + + + Any process that modulates the frequency, rate or extent of myoblast proliferation. + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of defecation. + regulation of defecation + + + + + Any process that modulates the frequency, rate or extent of defecation. + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of defecation. + negative regulation of defecation + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of defecation. + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of defecation. + positive regulation of defecation + + + + + Any process that activates or increases the frequency, rate or extent of defecation. + GOC:obol + @@ -98840,8 +145919,16 @@ + Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. regulation of endothelial cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. + GOC:mah + GOC:mtg_apoptosis + @@ -98867,8 +145954,17 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. negative regulation of endothelial cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + @@ -98894,8 +145990,17 @@ + Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. positive regulation of endothelial cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. + GOC:BHF + GOC:mah + GOC:mtg_apoptosis + @@ -98920,8 +146025,15 @@ + Any process that modulates the frequency, rate or extent of oxygen metabolic process. regulation of oxygen metabolic process + + + + Any process that modulates the frequency, rate or extent of oxygen metabolic process. + GOC:mah + @@ -98947,8 +146059,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process. negative regulation of oxygen metabolic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process. + GOC:mah + @@ -98974,8 +146093,15 @@ + Any process that activates or increases the frequency, rate or extent of oxygen metabolic process. positive regulation of oxygen metabolic process + + + + Any process that activates or increases the frequency, rate or extent of oxygen metabolic process. + GOC:mah + @@ -99000,8 +146126,15 @@ + Any process that modulates the frequency, rate or extent of mesoderm development. regulation of mesoderm development + + + + Any process that modulates the frequency, rate or extent of mesoderm development. + GOC:BHF + @@ -99027,8 +146160,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. negative regulation of mesoderm development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. + GOC:BHF + @@ -99054,8 +146194,15 @@ + Any process that activates or increases the frequency, rate or extent of mesoderm development. positive regulation of mesoderm development + + + + Any process that activates or increases the frequency, rate or extent of mesoderm development. + GOC:BHF + @@ -99080,8 +146227,15 @@ + Any process that modulates the frequency, rate or extent of ectoderm development. regulation of ectoderm development + + + + Any process that modulates the frequency, rate or extent of ectoderm development. + GOC:BHF + @@ -99107,8 +146261,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. negative regulation of ectoderm development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. + GOC:BHF + @@ -99134,8 +146295,15 @@ + Any process that activates or increases the frequency, rate or extent of ectoderm development. positive regulation of ectoderm development + + + + Any process that activates or increases the frequency, rate or extent of ectoderm development. + GOC:BHF + @@ -99160,8 +146328,15 @@ + Any process that modulates the frequency, rate or extent of lymphocyte migration. regulation of lymphocyte migration + + + + Any process that modulates the frequency, rate or extent of lymphocyte migration. + GOC:mah + @@ -99187,8 +146362,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration. negative regulation of lymphocyte migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration. + GOC:mah + @@ -99214,8 +146396,15 @@ + Any process that activates or increases the frequency, rate or extent of lymphocyte migration. positive regulation of lymphocyte migration + + + + Any process that activates or increases the frequency, rate or extent of lymphocyte migration. + GOC:mah + @@ -99240,8 +146429,15 @@ + Any process that modulates the frequency, rate or extent of T cell migration. regulation of T cell migration + + + + Any process that modulates the frequency, rate or extent of T cell migration. + GOC:mah + @@ -99267,8 +146463,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration. negative regulation of T cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration. + GOC:mah + @@ -99294,8 +146497,15 @@ + Any process that activates or increases the frequency, rate or extent of T cell migration. positive regulation of T cell migration + + + + Any process that activates or increases the frequency, rate or extent of T cell migration. + GOC:mah + @@ -99320,8 +146530,15 @@ + Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration. regulation of hematopoietic stem cell migration + + + + Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration. + GOC:obol + @@ -99347,8 +146564,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration. negative regulation of hematopoietic stem cell migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration. + GOC:obol + @@ -99374,8 +146598,15 @@ + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration. positive regulation of hematopoietic stem cell migration + + + + Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration. + GOC:obol + @@ -99400,8 +146631,15 @@ + Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. regulation of cell proliferation involved in compound eye morphogenesis + + + + Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. + GOC:obol + @@ -99427,8 +146665,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. negative regulation of cell proliferation involved in compound eye morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. + GOC:obol + @@ -99454,8 +146699,15 @@ + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. positive regulation of cell proliferation involved in compound eye morphogenesis + + + + Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. + GOC:obol + @@ -99481,8 +146733,15 @@ + Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis. regulation of dendritic cell chemotaxis + + + + Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis. + GOC:obol + @@ -99509,8 +146768,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis. negative regulation of dendritic cell chemotaxis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis. + GOC:obol + @@ -99537,8 +146803,15 @@ + Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis. positive regulation of dendritic cell chemotaxis + + + + Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis. + GOC:obol + @@ -99563,8 +146836,15 @@ + Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis. regulation of myeloid dendritic cell chemotaxis + + + + Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis. + GOC:obol + @@ -99590,8 +146870,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis. negative regulation of myeloid dendritic cell chemotaxis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis. + GOC:obol + @@ -99617,8 +146904,15 @@ + Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis. positive regulation of myeloid dendritic cell chemotaxis + + + + Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis. + GOC:obol + @@ -99644,8 +146938,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. negative regulation of gastrulation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. + GOC:obol + @@ -99671,8 +146972,15 @@ + Any process that activates or increases the frequency, rate or extent of gastrulation. positive regulation of gastrulation + + + + Any process that activates or increases the frequency, rate or extent of gastrulation. + GOC:obol + @@ -99697,8 +147005,15 @@ + Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly. regulation of dendritic cell dendrite assembly + + + + Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly. + GOC:obol + @@ -99724,8 +147039,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly. negative regulation of dendritic cell dendrite assembly + + + + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly. + GOC:obol + @@ -99751,8 +147073,15 @@ + Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly. positive regulation of dendritic cell dendrite assembly + + + + Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly. + GOC:obol + @@ -99778,8 +147107,15 @@ + Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. positive regulation of DNA biosynthetic process + + + + Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. + GOC:obol + @@ -99805,8 +147141,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. negative regulation of stem cell proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. + GOC:dph + @@ -99832,8 +147175,15 @@ + Any process that activates or increases the frequency, rate or extent of stem cell proliferation. positive regulation of stem cell proliferation + + + + Any process that activates or increases the frequency, rate or extent of stem cell proliferation. + GOC:dph + @@ -99858,8 +147208,16 @@ + Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process. regulation of dendritic cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -99885,8 +147243,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process. negative regulation of dendritic cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -99912,8 +147278,16 @@ + Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process. positive regulation of dendritic cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -99938,8 +147312,16 @@ + Any process that modulates the frequency, rate or extent of motor neuron apoptotic process. regulation of motor neuron apoptotic process + + + + Any process that modulates the frequency, rate or extent of motor neuron apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -99965,8 +147347,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process. negative regulation of motor neuron apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -99992,8 +147382,120 @@ + Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process. positive regulation of motor neuron apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process. + GOC:mtg_apoptosis + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process. + regulation of type B pancreatic cell apoptotic process + + + + + Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process. + negative regulation of type B pancreatic cell apoptotic process + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process. + positive regulation of type B pancreatic cell apoptotic process + + + + + Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -100019,8 +147521,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation. regulation of cardiac muscle cell myoblast differentiation + + + + Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation. + GOC:obol + @@ -100047,8 +147556,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation. negative regulation of cardiac muscle cell myoblast differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation. + GOC:obol + @@ -100075,8 +147591,15 @@ + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation. positive regulation of cardiac muscle cell myoblast differentiation + + + + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation. + GOC:obol + @@ -100102,8 +147625,15 @@ + Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. regulation of cardiac muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. + GOC:BHF + @@ -100130,8 +147660,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. negative regulation of cardiac muscle cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. + GOC:BHF + @@ -100158,8 +147695,15 @@ + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. positive regulation of cardiac muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. + GOC:BHF + @@ -100184,8 +147728,15 @@ + Any process that modulates the frequency, rate or extent of stem cell differentiation. regulation of stem cell differentiation + + + + Any process that modulates the frequency, rate or extent of stem cell differentiation. + GOC:obol + @@ -100211,8 +147762,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. negative regulation of stem cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. + GOC:obol + @@ -100238,8 +147796,15 @@ + Any process that activates or increases the frequency, rate or extent of stem cell differentiation. positive regulation of stem cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of stem cell differentiation. + GOC:obol + @@ -100264,8 +147829,15 @@ + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. regulation of mesenchymal cell proliferation involved in lung development + + + + Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. + PMID:21513708 + @@ -100293,8 +147865,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. negative regulation of mesenchymal cell proliferation involved in lung development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. + PMID:21513708 + @@ -100322,8 +147901,15 @@ + Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. positive regulation of mesenchymal cell proliferation involved in lung development + + + + Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. + PMID:21513708 + @@ -100348,8 +147934,15 @@ + Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. regulation of epithelial cell proliferation involved in lung morphogenesis + + + + Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. + PMID:21513708 + @@ -100375,8 +147968,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. negative regulation of epithelial cell proliferation involved in lung morphogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. + PMID:21513708 + @@ -100402,8 +148002,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation. negative regulation of myoblast proliferation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation. + GOC:obol + @@ -100428,8 +148035,15 @@ + Any process that modulates the frequency, rate or extent of heart morphogenesis. regulation of heart morphogenesis + + + + Any process that modulates the frequency, rate or extent of heart morphogenesis. + GOC:BHF + @@ -100456,8 +148070,15 @@ + Any process that modulates the frequency, rate or extent of steroid hormone secretion. regulation of steroid hormone secretion + + + + Any process that modulates the frequency, rate or extent of steroid hormone secretion. + GOC:sl + @@ -100485,8 +148106,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. negative regulation of steroid hormone secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. + GOC:sl + @@ -100514,8 +148142,15 @@ + Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. positive regulation of steroid hormone secretion + + + + Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. + GOC:sl + @@ -100540,8 +148175,15 @@ + Any process that modulates the frequency, rate or extent of androgen secretion. regulation of androgen secretion + + + + Any process that modulates the frequency, rate or extent of androgen secretion. + GOC:sl + @@ -100567,8 +148209,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion. negative regulation of androgen secretion + + + + Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion. + GOC:sl + @@ -100594,8 +148243,50 @@ + Any process that activates or increases the frequency, rate or extent of androgen secretion. positive regulation of androgen secretion + + + + Any process that activates or increases the frequency, rate or extent of androgen secretion. + GOC:sl + + + + + + + + + + + + + + + + + + + + + + + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state. + mesenchymal cell differentiation involved in renal system development + + + + + The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state. + GOC:mtg_kidney_jan10 + GOC:obol + GOC:yaf + @@ -100620,8 +148311,15 @@ + Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. regulation of skeletal muscle cell differentiation + + + + Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. + GOC:obol + @@ -100647,8 +148345,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation. negative regulation of skeletal muscle cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation. + GOC:obol + @@ -100674,8 +148379,15 @@ + Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation. positive regulation of skeletal muscle cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation. + GOC:obol + @@ -100701,8 +148413,15 @@ + Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. regulation of endothelial cell chemotaxis + + + + Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. + GOC:BHF + @@ -100729,8 +148448,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis. negative regulation of endothelial cell chemotaxis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis. + GOC:BHF + @@ -100757,8 +148483,15 @@ + Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. positive regulation of endothelial cell chemotaxis + + + + Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. + GOC:BHF + @@ -100783,8 +148516,16 @@ + Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. regulation of mesenchymal cell apoptotic process + + + + Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -100810,8 +148551,16 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process. negative regulation of mesenchymal cell apoptotic process + + + + Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -100837,8 +148586,16 @@ + Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process. positive regulation of mesenchymal cell apoptotic process + + + + Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process. + GOC:mtg_apoptosis + GOC:obol + @@ -100863,8 +148620,15 @@ + Any process that modulates the frequency, rate or extent of RNA biosynthetic process. regulation of RNA biosynthetic process + + + + Any process that modulates the frequency, rate or extent of RNA biosynthetic process. + GOC:dph + @@ -100889,8 +148653,15 @@ + Any process that modulates the frequency, rate or extent of dendritic cell differentiation. regulation of dendritic cell differentiation + + + + Any process that modulates the frequency, rate or extent of dendritic cell differentiation. + GOC:obol + @@ -100916,8 +148687,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation. negative regulation of dendritic cell differentiation + + + + Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation. + GOC:obol + @@ -100943,8 +148721,15 @@ + Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation. positive regulation of dendritic cell differentiation + + + + Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation. + GOC:obol + @@ -100969,8 +148754,15 @@ + Any process that modulates the frequency, rate or extent of osteoclast development. regulation of osteoclast development + + + + Any process that modulates the frequency, rate or extent of osteoclast development. + GOC:obol + @@ -100996,8 +148788,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development. negative regulation of osteoclast development + + + + Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development. + GOC:obol + @@ -101023,8 +148822,15 @@ + Any process that activates or increases the frequency, rate or extent of osteoclast development. positive regulation of osteoclast development + + + + Any process that activates or increases the frequency, rate or extent of osteoclast development. + GOC:obol + @@ -101049,8 +148855,15 @@ + Any process that modulates the frequency, rate or extent of vasculogenesis. regulation of vasculogenesis + + + + Any process that modulates the frequency, rate or extent of vasculogenesis. + GOC:obol + @@ -101076,8 +148889,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis. negative regulation of vasculogenesis + + + + Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis. + GOC:obol + @@ -101103,8 +148923,15 @@ + Any process that activates or increases the frequency, rate or extent of vasculogenesis. positive regulation of vasculogenesis + + + + Any process that activates or increases the frequency, rate or extent of vasculogenesis. + GOC:obol + @@ -101141,8 +148968,15 @@ + Any process that modulates the frequency, rate or extent of neuron migration. regulation of neuron migration + + + + Any process that modulates the frequency, rate or extent of neuron migration. + GOC:obol + @@ -101168,8 +149002,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration. negative regulation of neuron migration + + + + Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration. + GOC:obol + @@ -101195,8 +149036,15 @@ + Any process that activates or increases the frequency, rate or extent of neuron migration. positive regulation of neuron migration + + + + Any process that activates or increases the frequency, rate or extent of neuron migration. + GOC:obol + @@ -101222,8 +149070,15 @@ + Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. regulation of apoptotic signaling pathway + + + + Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. + GOC:mtg_apoptosis + @@ -101250,8 +149105,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. negative regulation of apoptotic signaling pathway + + + + Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. + GOC:mtg_apoptosis + @@ -101284,8 +149146,15 @@ + Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. positive regulation of apoptotic signaling pathway + + + + Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. + GOC:mtg_apoptosis + @@ -101311,8 +149180,15 @@ + Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. negative regulation of chromosome organization + + + + Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. + GOC:obol + @@ -101338,8 +149214,15 @@ + Any process that activates or increases the frequency, rate or extent of chromosome organization. positive regulation of chromosome organization + + + + Any process that activates or increases the frequency, rate or extent of chromosome organization. + GOC:obol + @@ -101352,6 +149235,9 @@ + GC_ID:1 + PMID:30365038 + PMID:32761142 root @@ -101361,6 +149247,7 @@ + GC_ID:1 Teleostomi @@ -101370,6 +149257,7 @@ + GC_ID:1 Euteleostomi @@ -101379,6 +149267,7 @@ + GC_ID:1 Ecdysozoa @@ -101388,6 +149277,7 @@ + GC_ID:1 Zygnemophyceae @@ -101397,6 +149287,7 @@ + GC_ID:1 Streptophytina @@ -101406,6 +149297,7 @@ + GC_ID:1 cellular organisms @@ -101415,6 +149307,9 @@ + GC_ID:1 + PMID:22839753 + PMID:25450099 Archelosauria @@ -101424,6 +149319,7 @@ + GC_ID:1 Dipnotetrapodomorpha @@ -101433,15 +149329,31 @@ + GC_ID:1 + PMID:11062127 + PMID:9342353 Eumycetozoa + + + + + GC_ID:1 + PMID:11743200 + PMID:11791233 + Boreoeutheria + + + + + GC_ID:1 Acrogymnospermae @@ -101451,6 +149363,7 @@ + GC_ID:1 Gnetidae @@ -101460,6 +149373,7 @@ + GC_ID:1 Saccharomycotina @@ -101469,6 +149383,7 @@ + GC_ID:1 Schizosaccharomycetes @@ -101478,6 +149393,7 @@ + GC_ID:1 Actinopteri @@ -101487,6 +149403,9 @@ + GC_ID:1 + PMID:10874751 + PMID:11557979 Pancrustacea @@ -101496,6 +149415,9 @@ + GC_ID:1 + PMID:11557979 + PMID:9727836 Mandibulata @@ -101505,6 +149427,34 @@ + GC_ID:11 + PMID:10425795 + PMID:10425796 + PMID:10425797 + PMID:10490293 + PMID:10843050 + PMID:10939651 + PMID:10939673 + PMID:10939677 + PMID:11211268 + PMID:11321083 + PMID:11321113 + PMID:11411719 + PMID:11540071 + PMID:11542017 + PMID:11542087 + PMID:11760965 + PMID:12054223 + PMID:2112744 + PMID:270744 + PMID:32628106 + PMID:36748408 + PMID:7520741 + PMID:8123559 + PMID:8186100 + PMID:8590690 + PMID:9103655 + PMID:9336922 Bacteria @@ -101514,6 +149464,8 @@ + GC_ID:1 + PMID:29367151 Dictyosteliaceae @@ -101523,15 +149475,55 @@ + GC_ID:1 + PMID:29367151 Dictyosteliales + + + + + GC_ID:1 + Homininae + + + + + GC_ID:11 + PMID:10425795 + PMID:10425796 + PMID:10425797 + PMID:10490293 + PMID:10843050 + PMID:10939651 + PMID:10939673 + PMID:10939677 + PMID:11211268 + PMID:11321083 + PMID:11321113 + PMID:11411719 + PMID:11540071 + PMID:11541975 + PMID:11542064 + PMID:11542149 + PMID:11760965 + PMID:12054223 + PMID:2112744 + PMID:25527841 + PMID:270744 + PMID:32628106 + PMID:36748408 + PMID:8123559 + PMID:8590690 + PMID:9103655 + PMID:9336922 Archaea @@ -101541,6 +149533,7 @@ + GC_ID:1 Evosea @@ -101550,6 +149543,7 @@ + GC_ID:1 Discoba @@ -101559,6 +149553,7 @@ + GC_ID:1 Zygnematophycidae @@ -101568,6 +149563,7 @@ + GC_ID:1 Sar @@ -101577,15 +149573,53 @@ + GC_ID:1 + PMID:23020233 + PMID:30257078 Eukaryota + + + + + GC_ID:1 + PMID:11214319 + PMID:12082125 + PMID:12878460 + PMID:15522813 + Euarchontoglires + + + + + + + + + GC_ID:1 + Simiiformes + + + + + + + + + GC_ID:1 + Hominoidea + + + + + GC_ID:1 Zygnematales @@ -101595,6 +149629,7 @@ + GC_ID:1 Embryophyta @@ -101604,6 +149639,7 @@ + GC_ID:1 Teleostei @@ -101613,6 +149649,7 @@ + GC_ID:1 Tetrapoda @@ -101622,6 +149659,7 @@ + GC_ID:1 Amniota @@ -101631,6 +149669,7 @@ + GC_ID:1 Theria <mammals> @@ -101640,6 +149679,7 @@ + GC_ID:1 Sauria @@ -101649,6 +149689,10 @@ + GC_ID:1 + PMID:11062127 + PMID:29367151 + PMID:9342353 Dictyostelia @@ -101658,6 +149702,9 @@ + GC_ID:1 + PMID:16248873 + PMID:30257078 Viridiplantae @@ -101667,6 +149714,7 @@ + GC_ID:1 Coniferophyta @@ -101676,6 +149724,7 @@ + GC_ID:1 Opisthokonta @@ -101685,6 +149734,7 @@ + GC_ID:1 Metazoa @@ -101694,6 +149744,7 @@ + GC_ID:1 Bilateria @@ -101703,6 +149754,7 @@ + GC_ID:1 Protostomia @@ -101712,6 +149764,7 @@ + GC_ID:1 Deuterostomia @@ -101721,6 +149774,7 @@ + GC_ID:1 Alveolata @@ -101730,6 +149784,7 @@ + GC_ID:1 Euglenozoa @@ -101739,6 +149794,7 @@ + GC_ID:1 Gnetopsida @@ -101748,6 +149804,7 @@ + GC_ID:1 Gnetales @@ -101757,6 +149814,8 @@ + GC_ID:1 + PMID:25249442 Magnoliopsida @@ -101766,6 +149825,7 @@ + GC_ID:1 Schizosaccharomycetales @@ -101775,15 +149835,27 @@ + GC_ID:1 Streptophyta + + + + + GC_ID:1 + Haplorrhini + + + + + GC_ID:1 Glaucocystophyceae @@ -101793,6 +149865,7 @@ + GC_ID:1 Mammalia @@ -101802,6 +149875,7 @@ + GC_ID:1 Neopterygii @@ -101811,6 +149885,7 @@ + GC_ID:1 Dinosauria @@ -101820,6 +149895,7 @@ + GC_ID:1 Saurischia @@ -101829,6 +149905,7 @@ + GC_ID:1 Theropoda @@ -101838,6 +149915,7 @@ + GC_ID:1 Coelurosauria @@ -101847,6 +149925,12 @@ + GC_ID:1 + PMID:15689432 + PMID:16151185 + PMID:17010206 + PMID:17051209 + PMID:17572334 Dikarya @@ -101856,6 +149940,7 @@ + GC_ID:1 Taphrinomycotina @@ -101865,6 +149950,9 @@ + GC_ID:1 + PMID:11062127 + PMID:12684019 Fungi @@ -101874,6 +149962,8 @@ + GC_ID:1 + PMID:17572334 Ascomycota @@ -101883,6 +149973,7 @@ + GC_ID:1 Saccharomycetes @@ -101892,6 +149983,7 @@ + GC_ID:1 Saccharomycetales @@ -101901,6 +149993,7 @@ + GC_ID:1 Saccharomycetaceae @@ -101910,6 +150003,7 @@ + GC_ID:1 Schizosaccharomycetaceae @@ -101919,6 +150013,7 @@ + GC_ID:1 Schizosaccharomyces @@ -101928,6 +150023,7 @@ + GC_ID:1 Schizosaccharomyces pombe @@ -101937,6 +150033,7 @@ + GC_ID:1 Saccharomyces @@ -101946,6 +150043,7 @@ + GC_ID:1 Saccharomyces cerevisiae @@ -101955,6 +150053,7 @@ + GC_ID:1 Insecta @@ -101964,6 +150063,9 @@ + GC_ID:1 + PMID:23020233 + PMID:30257078 Amoebozoa @@ -101973,6 +150075,8 @@ + GC_ID:1 + PMID:29367151 Dictyostelium @@ -101982,6 +150086,7 @@ + GC_ID:1 Tracheophyta @@ -101991,6 +150096,7 @@ + GC_ID:1 Spermatophyta @@ -102000,6 +150106,7 @@ + GC_ID:1 Eumetazoa @@ -102009,6 +150116,7 @@ + GC_ID:1 Arthropoda @@ -102018,6 +150126,7 @@ + GC_ID:1 Hexapoda @@ -102027,6 +150136,7 @@ + GC_ID:1 saccharomyceta @@ -102036,6 +150146,7 @@ + GC_ID:1 Chordata @@ -102045,6 +150156,7 @@ + GC_ID:1 Vertebrata <vertebrates> @@ -102054,6 +150166,7 @@ + GC_ID:1 Gnathostomata <vertebrates> @@ -102063,6 +150176,7 @@ + GC_ID:1 Euphyllophyta @@ -102072,6 +150186,7 @@ + GC_ID:1 Actinopterygii @@ -102081,6 +150196,7 @@ + GC_ID:1 Sarcopterygii @@ -102090,6 +150206,7 @@ + GC_ID:1 Sauropsida @@ -102099,6 +150216,7 @@ + GC_ID:1 Archosauria @@ -102108,6 +150226,7 @@ + GC_ID:1 Aves @@ -102117,6 +150236,7 @@ + GC_ID:1 Panarthropoda @@ -102126,11 +150246,72 @@ + GC_ID:1 Craniata <chordates> + + + + + GC_ID:1 + Eutheria + + + + + + + + + GC_ID:1 + Primates + + + + + + + + + GC_ID:1 + Catarrhini + + + + + + + + + GC_ID:1 + Hominidae + + + + + + + + + GC_ID:1 + Homo + + + + + + + + + GC_ID:1 + Homo sapiens + + + + @@ -102155,6 +150336,12 @@ + + + + + + @@ -102167,6 +150354,12 @@ + + + + + + @@ -102221,6 +150414,12 @@ + + + + + + @@ -102233,6 +150432,12 @@ + + + + + + @@ -102263,6 +150468,12 @@ + + + + + + @@ -102323,6 +150534,12 @@ + + + + + + @@ -102755,6 +150972,12 @@ + + + + + + @@ -102779,11 +151002,112 @@ + + + + + A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids. + region + + + + + A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids. + SO:ke + + + + + + + + Any extent of continuous biological sequence. + sequence_feature + + + + + Any extent of continuous biological sequence. + LAMHDI:mb + SO:ke + + + + + + + + + + + + + + + A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions. + http://en.wikipedia.org/wiki/Gene + This term is mapped to MGED. Do not obsolete without consulting MGED ontology. A gene may be considered as a unit of inheritance. + gene + + + + + A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions. + SO:immuno_workshop + + + + + http://en.wikipedia.org/wiki/Gene + wiki + + + + + A collection of discontinuous sequences. sequence_collection + + + + A collection of discontinuous sequences. + SO:ke + + + + + + + + + A region defined by its disposition to be involved in a biological process. + biological_region + + + + + A region defined by its disposition to be involved in a biological process. + SO:cb + + + + + + + + + A collection of related genes. + gene_group + + + + + A collection of related genes. + SO:ma + @@ -102791,11 +151115,16 @@ - - - + An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity. + BFO:0000003 processual entity + + + + An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity. + span:ProcessualEntity + @@ -102837,6 +151166,71 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The clusters of hormone-producing cells that are scattered throughout the pancreas. + AAO:0010406 + BTO:0000991 + CALOHA:TS-0741 + EFO:0000856 + EMAPA:32927 + EV:0100130 + FMA:16016 + GAID:324 + MA:0000127 + MAT:0000076 + MESH:D007515 + MIAA:0000076 + NCIT:C12608 + VHOG:0000646 + Wikipedia:Islets_of_Langerhans + XAO:0000159 + islet of Langerhans + + + + + The clusters of hormone-producing cells that are scattered throughout the pancreas. + MA:0000127 + MESH:A03.734.414 + MP:0005215 + + + + @@ -102859,8 +151253,21 @@ + A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]. + BTO:0002107 + FMA:85391 + FMA:85392 + NCIT:C13167 + SCTID:68439008 + Wikipedia:Submucosa submucosa + + + + A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]. + Wikipedia:Submucosa + @@ -102874,9 +151281,40 @@ - + A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. + AAO:0000429 + BAMS:PNS + BILA:0000081 + BIRNLEX:1111 + BTO:0001028 + CALOHA:TS-0808 + EFO:0000891 + EHDAA2:0001445 + EHDAA:2893 + EMAPA:16665 + EV:0100335 + FMA:9903 + GAID:715 + MA:0000218 + MAT:0000338 + MESH:D017933 + MIAA:0000338 + NCIT:C12465 + SCTID:362292005 + TAO:0000142 + VHOG:0000399 + Wikipedia:Peripheral_nervous_system + XAO:0000178 + ZFA:0000142 + neuronames:3232 peripheral nervous system + + + + A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. + GO:0007422 + @@ -102896,8 +151334,34 @@ + The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]. + AAO:0010487 + BIRNLEX:2516 + BTO:0001832 + CALOHA:TS-2050 + EFO:0000893 + EHDAA2:0001971 + EHDAA:3769 + EMAPA:16985 + FMA:9906 + GAID:710 + MA:0000225 + MESH:D013564 + MIAA:0000100 + NCIT:C12795 + SCTID:362484004 + TAO:0001576 + VHOG:0000384 + Wikipedia:Sympathetic_nervous_system + ZFA:0001576 sympathetic nervous system + + + + The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]. + GO:0048485 + @@ -102924,8 +151388,27 @@ + Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. + EHDAA:6530 + EV:0100152 + FMA:86166 + GAID:933 + MA:0000151 + MAT:0000284 + MESH:D012867 + MIAA:0000284 + SCTID:20795001 + VHOG:0000860 + Wikipedia:Skin zone of skin + + + + Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. + Wikipedia:Skin + http://orcid.org/0000-0002-6601-2165 + @@ -102933,11 +151416,168 @@ - - - + A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. + AEO:0000192 + CARO:0000010 + FMA:50705 + Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. non-material anatomical boundary + + + + A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. + CARO:0000010 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin. + BTO:0000650 + CALOHA:TS-1302 + EFO:0002542 + EMAPA:35305 + EV:0100129 + FMA:16018 + MA:0001582 + NCIT:C32509 + SCTID:361339003 + TAO:0001260 + VHOG:0000049 + Wikipedia:Islets_of_Langerhans + ZFA:0001260 + endocrine pancreas + + + + + The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin. + GO:GO + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]. + AAO:0010407 + BTO:0000434 + CALOHA:TS-1241 + EMAPA:35328 + EV:0100093 + FMA:16017 + MA:0002415 + NCIT:C32546 + SCTID:248202004 + TAO:0001249 + VHOG:0000048 + Wikipedia:Exocrine_component_of_pancreas + XAO:0000137 + ZFA:0001249 + exocrine pancreas + + + + + The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]. + GOC:GO + http://orcid.org/0000-0002-6601-2165 + @@ -102968,8 +151608,20 @@ + A light sensing organ composed of ommatidia. + BTO:0001921 + HAO:0000217 + TGMA:0000024 + Wikipedia:Compound_eye compound eye + + + + A light sensing organ composed of ommatidia. + FB:gg + Wikipedia:Compound_eye + @@ -103016,8 +151668,30 @@ + An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid. + AAO:0010340 + BIRNLEX:1169 + BTO:0004688 + EHDAA2:0000484 + EHDAA:936 + EMAPA:16198 + FMA:54448 + MA:0000261 + NCIT:C12401 + SCTID:181143004 + TAO:0000107 + VHOG:0000275 + XAO:0000179 + ZFA:0000107 camera-type eye + + + + An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid. + GO:0043010 + https://orcid.org/0000-0002-6601-2165 + @@ -103048,8 +151722,31 @@ + An organ that is capable of transducing sensory stimulus to the nervous system. + AEO:0000094 + BSA:0000121 + BTO:0000202 + CALOHA:TS-2043 + EHDAA2:0001824 + EHDAA:500 + EMAPA:35955 + GAID:63 + HAO:0000930 + MA:0000017 + MESH:D012679 + NCIT:C33224 + SCTID:244485009 + VHOG:0001407 + WBbt:0006929 sense organ + + + + An organ that is capable of transducing sensory stimulus to the nervous system. + https://github.com/obophenotype/uberon/issues/549 + https://orcid.org/0000-0002-6601-2165 + @@ -103080,8 +151777,16 @@ + Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. + galen:Tube tube + + + + Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. + http://orcid.org/0000-0002-6601-2165 + @@ -103095,8 +151800,30 @@ + Major subdivision of an organism that protrudes from the body[DOS, CARO]. + AEO:0000193 + BILA:0000018 + BTO:0001492 + CARO:0010003 + EFO:0000799 + EHDAA2:0003193 + EV:0100155 + HAO:0000144 + MAT:0000023 + MESH:D005121 + MIAA:0000023 + NCIT:C61460 + VSAO:0000075 + Wikipedia:Appendage + XAO:0000218 appendage + + + + Major subdivision of an organism that protrudes from the body[DOS, CARO]. + CARO:DOS + @@ -103122,8 +151849,20 @@ + A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions. + BTO:0002330 + FMA:62517 + NCIT:C32918 + SCTID:298225002 + Wikipedia:Lamina_propria lamina propria + + + + A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions. + Wikipedia:Lamina_propria + @@ -103148,8 +151887,19 @@ + A lamina propria that is part of a respiratory airway. + EMAPA:35877 + FMA:265157 + MA:0001858 + NCIT:C49305 lamina propria of trachea + + + + A lamina propria that is part of a respiratory airway. + OBOL:automatic + @@ -103169,8 +151919,43 @@ + The head is the anterior-most division of the body [GO]. + AAO:0010335 + AEO:0000106 + BILA:0000115 + BIRNLEX:1230 + BTO:0000282 + CALOHA:TS-0436 + EFO:0000964 + EHDAA2:0003106 + EMAPA:31858 + FMA:7154 + GAID:61 + HAO:0000397 + MA:0000023 + MAT:0000294 + MESH:D006257 + MIAA:0000294 + NCIT:C12419 + SCTID:302548004 + SPD:0000016 + TAO:0001114 + TGMA:0000002 + VHOG:0001644 + WBbt:0005739 + Wikipedia:Head + XAO:0003024 + ZFA:0001114 + galen:Head head + + + + The head is the anterior-most division of the body [GO]. + GO:0060322 + Wikipedia:Head + @@ -103197,8 +151982,24 @@ + Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. + FMA:9581 + GAID:19 + MESH:D012704 + NCIT:C13169 + SCTID:362878009 + TAO:0005425 + Wikipedia:Serous_membrane + ZFA:0005425 serous membrane + + + + Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. + Wikipedia:Serous_membrane + https://github.com/obophenotype/uberon/issues/86 + @@ -103236,8 +152037,36 @@ + Dense regular connective tissue that connects muscle to bone[VSAO]. + AEO:0000091 + BTO:0001356 + CALOHA:TS-1021 + EHDAA2:0003091 + EMAPA:35854 + EV:0100149 + FMA:9721 + GAID:276 + MA:0000115 + MESH:D013710 + NCIT:C13045 + SCTID:256667004 + VHOG:0001286 + VSAO:0000073 + Wikipedia:Tendon + XAO:0000173 + ZFA:0005647 + galen:Tendon tendon + + + + Dense regular connective tissue that connects muscle to bone[VSAO]. + GO_REF:0000034 + VSAO:0000073 + Wikipedia:Tendon + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -103263,9 +152092,45 @@ - + A biological tissue mass, most commonly a mass of nerve cell bodies. + AAO:0010426 + AEO:0000135 + BAMS:G + BTO:0000497 + CALOHA:TS-0397 + EFO:0000899 + EHDAA2:0003135 + EHDAA:2897 + EHDAA:4662 + EHDAA:5621 + EHDAA:918 + EMAPA:32846 + EV:0100372 + FMA:5884 + MA:0002406 + MAT:0000207 + MAT:0000343 + MESH:D005724 + MIAA:0000207 + MIAA:0000343 + NCIT:C12719 + NLXANAT:100302 + TAO:0000190 + TGMA:0001016 + VHOG:0000156 + WBbt:0005189 + Wikipedia:Ganglion + XAO:0000209 + ZFA:0000190 ganglion + + + + A biological tissue mass, most commonly a mass of nerve cell bodies. + Wikipedia:Ganglion + https://github.com/obophenotype/uberon/issues/300 + @@ -103273,8 +152138,17 @@ + An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity. + TGMA:0000729 + Wikipedia:Eye#Simple_eyes simple eye + + + + An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity. + Wikipedia:Eye#Simple_eyes + @@ -103288,9 +152162,15 @@ - + A tubular structure that contains, conveys body fluid, such as blood or lymph. vessel + + + + A tubular structure that contains, conveys body fluid, such as blood or lymph. + https://orcid.org/0000-0002-6601-2165 + @@ -103316,8 +152196,84 @@ + A tubular structure that transports secreted or excreted substances. + AAO:0011123 + FMA:30320 + NCIT:C12948 + SCTID:91726008 + TAO:0005171 + Wikipedia:Duct_(anatomy) + XAO:0004000 + ZFA:0005171 + galen:Duct duct + + + + A tubular structure that transports secreted or excreted substances. + http://orcid.org/0000-0002-6601-2165 + http://www.siumed.edu/~dking2/intro/glands.htm#ducts + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]. + AAO:0010396 + BTO:0000706 + CALOHA:TS-1306 + EFO:0000840 + EMAPA:19252 + EV:0100077 + FMA:7201 + GAID:306 + MA:0000333 + MESH:D007420 + MIAA:0000046 + NCIT:C12379 + SCTID:181254001 + VHOG:0000054 + Wikipedia:Large_intestine_(anatomy) + XAO:0000131 + galen:LargeIntestine + large intestine + + + + + A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]. + ISBN:0073040584 + Wikipedia:Large_intestine_(anatomy) + @@ -103337,8 +152293,17 @@ + Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers. + FMA:82482 + galen:Wall anatomical wall + + + + Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers. + FMA:82482 + @@ -103352,11 +152317,34 @@ - - - + Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. + AAO:0010825 + AEO:0000003 + BILA:0000003 + CARO:0000003 + EHDAA2:0003003 + EMAPA:0 + FMA:305751 + FMA:67135 + GAID:781 + HAO:0000003 + MA:0003000 + MESH:D000825 + SCTID:362889002 + TAO:0000037 + TGMA:0001823 + VHOG:0001759 + XAO:0003000 + ZFA:0000037 + http://dbpedia.org/ontology/AnatomicalStructure anatomical structure + + + + Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. + CARO:0000003 + @@ -103383,11 +152371,26 @@ - - - + Anatomical structure that performs a specific function or group of functions [WP]. + BIRNLEX:4 + CARO:0020004 + EFO:0000634 + EMAPA:35949 + ENVO:01000162 + FMA:67498 + MA:0003001 + NCIT:C13018 + SCTID:272625005 + WBbt:0003760 + Wikipedia:Organ_(anatomy) organ + + + + Anatomical structure that performs a specific function or group of functions [WP]. + Wikipedia:Organ_(anatomy) + @@ -103395,8 +152398,16 @@ + A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. + FMA:86140 organ subunit + + + + A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. + http://orcid.org/0000-0002-6601-2165 + @@ -103410,11 +152421,21 @@ - - - + A multicellular structure that is a part of an organ. + AAO:0011124 + BIRNLEX:16 + EFO:0000635 + FMA:82472 + SCTID:113343008 + SCTID:91717005 organ part + + + + A multicellular structure that is a part of an organ. + http://orcid.org/0000-0002-6601-2165 + @@ -103435,9 +152456,22 @@ - + Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts. + EHDAA2:0001606 + EHDAA:1568 + EHDAA:2219 + EMAPA:16737 + FMA:265130 + SCTID:361110005 + VHOG:0000393 respiratory tract + + + + Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts. + https://orcid.org/0000-0002-6601-2165 + @@ -103464,8 +152498,21 @@ + The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. + BTO:0001043 + BilaDO:0000004 + EFO:0001272 + FBdv:00005369 + WBls:0000041 + XtroDO:0000084 fully formed stage + + + + The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. + https://orcid.org/0000-0002-6601-2165 + @@ -103493,8 +152540,28 @@ + A life cycle stage that starts with fertilization and ends with the fully formed embryo. + BilaDO:0000002 + EV:0300001 + FBdv:00005289 + FMA:72652 + HsapDv:0000002 + MmusDv:0000002 + OGES:000000 + OGES:000022 + SCTID:296280003 + WBls:0000003 + WBls:0000092 + WBls:0000102 + XAO:1000012 embryo stage + + + + A life cycle stage that starts with fertilization and ends with the fully formed embryo. + http://orcid.org/0000-0002-6601-2165 + @@ -103509,11 +152576,17 @@ - - - + End of the life of an organism. + XAO:0000437 + XtroDO:0000085 death stage + + + + End of the life of an organism. + XAO:0000437 + @@ -103539,8 +152612,17 @@ + An section of a respiratory tract. + FMA:45660 + MA:0000434 proximo-distal subdivision of respiratory tract + + + + An section of a respiratory tract. + http://orcid.org/0000-0002-6601-2165 + @@ -103565,8 +152647,18 @@ + Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. + BIRNLEX:1157 + NCIT:C13040 + SCTID:25087005 regional part of nervous system + + + + Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. + BIRNLEX:1157 + @@ -103592,8 +152684,20 @@ + Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. + FMA:85544 + NCIT:C34076 + SCTID:118966000 + galen:ComplexSkeletalStructure subdivision of skeletal system + + + + Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + @@ -103608,8 +152712,27 @@ + The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. + EHDAA2:0001968 + EHDAA:1494 + EHDAA:350 + EHDAA:4784 + EHDAA:4790 + EHDAA:4796 + EHDAA:7860 + EMAPA:16096 + FMA:87656 + NCIT:C34309 + Wikipedia:External_ectoderm external ectoderm + + + + The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. + MGI:anna + MP:0012532 + @@ -103633,8 +152756,15 @@ + An anatomical structure that develops from the endoderm and the mesoderm. mixed endoderm/mesoderm-derived structure + + + + An anatomical structure that develops from the endoderm and the mesoderm. + https://orcid.org/0000-0002-6601-2165 + @@ -103662,8 +152792,15 @@ + An anatomical structure that develops from the ectoderm, mesoderm and endoderm. mixed ectoderm/mesoderm/endoderm-derived structure + + + + An anatomical structure that develops from the ectoderm, mesoderm and endoderm. + https://orcid.org/0000-0002-6601-2165 + @@ -103701,8 +152838,23 @@ + A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum. + BTO:0001508 + EHDAA2:0000005 + FMA:292334 + GAID:1295 + MESH:D009028 + NCIT:C34212 + SCTID:361474003 + Wikipedia:Morula morula + + + + A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum. + MP:0012130 + @@ -103728,9 +152880,28 @@ - + A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes. + BTO:0003135 + EHDAA2:0002220 + EHDAA:31 + EHDAA:62 + EMAPA:16035 + FMA:18674 + GAID:410 + MA:0001715 + MESH:D015044 + NCIT:C33896 + TAO:0001111 + Wikipedia:Zona_pellucida + ZFA:0001111 zona pellucida + + + + A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes. + Wikipedia:Zona_pellucida + @@ -103750,8 +152921,25 @@ + A mass of cells that develop into the body of the embryo and some extraembryonic tissues. + EFO:0000547 + EHDAA2:0000830 + EHDAA:40 + EMAPA:16041 + FMA:86557 + NCIT:C13740 + SCTID:361456007 + VHOG:0000742 + Wikipedia:Inner_cell_mass inner cell mass + + + + A mass of cells that develop into the body of the embryo and some extraembryonic tissues. + ISBN:0-683-40008-8 + MGI:pvb + @@ -103777,8 +152965,26 @@ + The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta. + BTO:0001079 + CALOHA:TS-1070 + EV:0100120 + FMA:83029 + GAID:1152 + MESH:D014327 + NCIT:C93292 + SCTID:362839005 + Wikipedia:Trophoblast + Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast] trophoblast + + + + The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta. + ISBN:0-683-40008-8 + MP:0005031 + @@ -103792,8 +152998,18 @@ + A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc. + FMA:293863 + NCIT:C34112 + Wikipedia:Bilaminar_disc bilaminar disc + + + + A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc. + MP:0003886 + @@ -103814,8 +153030,22 @@ + Stage succeeding embryo, including mature structure. + BilaDO:0000003 + OGES:000010 + OGES:000014 + OGES:000024 + WBls:0000022 + WBls:0000093 + WBls:0000103 post-embryonic stage + + + + Stage succeeding embryo, including mature structure. + https://orcid.org/0000-0002-6601-2165 + @@ -103829,8 +153059,16 @@ + Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]. + FMA:7145 membrane organ + + + + Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]. + FMA:7145 + @@ -103851,8 +153089,19 @@ + Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]. + TAO:0002173 + Wikipedia:Cardiac_neural_crest + XAO:0004190 + ZFA:0001648 cardiac neural crest + + + + Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]. + Wikipedia:Cardiac_neural_crest + @@ -103873,8 +153122,21 @@ + A lung lobe is one of the rounded projections that compose the lung[GO]. + EMAPA:36281 + FMA:7311 + MA:0003098 + NCIT:C34021 + SCTID:245524004 + galen:LobeOfLung lobe of lung + + + + A lung lobe is one of the rounded projections that compose the lung[GO]. + GOC:GO + @@ -103900,8 +153162,16 @@ + The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]. + FMA:73750 lung vasculature + + + + The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]. + GOC:GO + @@ -103922,11 +153192,20 @@ - - - + An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism. + FBdv:00000000 + HsapDv:0000001 + MmusDv:0000001 + OGES:000011 + ncithesaurus:Life life cycle + + + + An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism. + https://orcid.org/0000-0002-6601-2165 + @@ -103940,11 +153219,29 @@ - - - + A spatiotemporal region encompassing some part of the life cycle of an organism. + BILS:0000105 + EFO:0000399 + FBdv:00007012 + FMA:24120 + HsapDv:0000000 + MESH:D008018 + MmusDv:0000000 + OlatDv:0000010 + PdumDv:0000090 + WBls:0000002 + XAO:1000000 + ZFS:0000000 + ZFS:0100000 + ncithesaurus:Developmental_Stage life cycle stage + + + + A spatiotemporal region encompassing some part of the life cycle of an organism. + https://orcid.org/0000-0002-6601-2165 + @@ -103965,8 +153262,26 @@ + A stage at which the organism is a single cell produced by means of sexual reproduction. + BILS:0000106 + BilaDO:0000005 + EFO:0001322 + EHDAA:27 + FBdv:00005288 + NCIT:C12601 + PdumDv:0000100 + VHOG:0000745 + Wikipedia:Zygote + XAO:1000001 + ZFS:0000001 zygote stage + + + + A stage at which the organism is a single cell produced by means of sexual reproduction. + Wikipedia:Zygote + @@ -104004,8 +153319,28 @@ + The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. + BILS:0000107 + BilaDO:0000006 + EFO:0001290 + FBdv:00000054 + MESH:D002970 + MmusDv:0000004 + OGES:000015 + OGES:000020 + PdumDv:0000200 + Wikipedia:Cleavage_(embryo) + XAO:1000004 + ZFS:0000046 cleavage stage + + + + The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. + GO:0040016 + Wikipedia:Cleavage_(embryo) + @@ -104026,8 +153361,27 @@ + An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + BILS:0000108 + BilaDO:0000007 + EFO:0001282 + HsapDv:0000006 + MmusDv:0000007 + OGES:000003 + OGES:000016 + OGES:000021 + WBls:0000005 + Wikipedia:Blastula + XAO:1000003 + ZFS:0000045 blastula stage + + + + An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + Wikipedia:Blastula + @@ -104060,8 +153414,26 @@ + A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + BILS:0000109 + BilaDO:0000008 + EFO:0001296 + FBdv:00005317 + HsapDv:0000010 + MmusDv:0000013 + OGES:000004 + OGES:000019 + WBls:0000010 + XAO:1000005 + ZFS:0000047 gastrula stage + + + + A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + GO:0007369 + @@ -104094,8 +153466,20 @@ + Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + BILS:0000110 + BilaDO:0000009 + HsapDv:0000012 + MmusDv:0000017 + XAO:1000006 neurula stage + + + + Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + GO:0001841 + @@ -104122,8 +153506,22 @@ + A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. + BILS:0000111 + BilaDO:0000010 + HsapDv:0000015 + MmusDv:0000018 + OGES:000005 + OGES:000032 + Wikipedia:Organogenesis organogenesis stage + + + + A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. + Wikipedia:Organogenesis + @@ -104162,9 +153560,22 @@ - + The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin. + EMAPA:35521 + FMA:27533 + MA:0001782 + SCTID:201609008 lung connective tissue + + + + The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin. + ISBN:0-683-40008-8 + MGI:anna + MP:0002276 + PMID:14635660 + @@ -104201,8 +153612,18 @@ + The epithelial layer of the lung. + BTO:0001653 + EMAPA:32860 + MA:0001783 lung epithelium + + + + The epithelial layer of the lung. + MP:0006382 + @@ -104234,8 +153655,17 @@ + A tube in the respiratory system. Examples: bronchus, bronchiole, trachea. + FMA:12224 respiratory tube + + + + A tube in the respiratory system. Examples: bronchus, bronchiole, trachea. + GO:0030323 + http://orcid.org/0000-0002-6601-2165 + @@ -104262,8 +153692,22 @@ + Structure derived from foregut that becomes a lung[GO]. + BTO:0001643 + EHDAA2:0004089 + NCIT:C34260 + NCIT:C34282 + SCTID:361427007 + Wikipedia:Respiratory_bud lung bud + + + + Structure derived from foregut that becomes a lung[GO]. + GO:0060431 + Wikipedia:Respiratory_bud + @@ -104283,8 +153727,19 @@ + A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. + CARO:0001001 + NLX:147821 neuron projection bundle + + + + A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. + CARO:0001001 + FBC:DOS + FBbt:00005099 + @@ -104304,8 +153759,20 @@ + A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO). + AEO:0000136 + FMA:83686 + NCIT:C13197 + NLX:28443 + Wikipedia:Nucleus_(neuroanatomy) neural nucleus + + + + A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO). + NLX:28443 + @@ -104330,8 +153797,19 @@ + Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves. + FMA:54501 + NLX:28532 + SCTID:280160003 + Wikipedia:Cranial_nerve_nucleus cranial nerve nucleus + + + + Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves. + NLX:28532 + @@ -104381,17 +153859,234 @@ + FMA:30322 + FMA:82500 + MESH:D008566 + NCIT:C12749 membranous layer + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus. + BTO:0001978 + CALOHA:TS-2160 + EMAPA:18256 + FMA:15703 + MA:0000330 + NCIT:C12375 + SCTID:245438008 + Wikipedia:Anal_canal + galen:AnalCanal + anal canal + + + + + The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus. + Wikipedia:Anal_canal + + + + + + + + + + + + + + + + + + + + + Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine. + AAO:0000246 + ANISEED:1235303 + BSA:0000093 + BTO:0000648 + CALOHA:TS-0490 + EFO:0000834 + EMAPA:32874 + EV:0100071 + FMA:7199 + GAID:295 + MA:0000328 + MA:0001524 + MESH:D007422 + MIAA:0000043 + NCIT:C12736 + SCTID:256876008 + TAO:0001338 + VHOG:0000056 + WBbt:0005772 + Wikipedia:Intestine + XAO:0000129 + ZFA:0001338 + galen:Intestine + intestine + + + + + Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine. + GOC:GO + Wikipedia:Intestine + + + + + Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]. + FMA:3724 + SCTID:91837002 orifice + + + + Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]. + FMA:3724 + + + + + + + + + + + + + + + + + + + + + + + + + + + Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures. + AAO:0000095 + GAID:1206 + MESH:D002988 + NCIT:C34127 + SCTID:362857006 + SCTID:370631000 + VHOG:0001186 + Wikipedia:Cloaca + XAO:0000244 + ZFA:0005781 + cloaca + + + + + Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures. + ISBN:0073040584 + Wikipedia:Cloaca + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]. + EHDAA2:0000256 + EHDAA:4895 + EMAPA:27573 + Wikipedia:Cloaca_(embryology) + embryonic cloaca + + + + + Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]. + MP:0010115 + Wikipedia:Cloaca_(embryology) + @@ -104428,8 +154123,44 @@ + The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). + AAO:0010355 + BTO:0001090 + BTO:0004698 + CALOHA:TS-1315 + EFO:0000825 + EHDAA2:0001326 + EHDAA:542 + EMAPA:16262 + FMA:49184 + GAID:75 + MA:0000341 + MA:0002474 + MAT:0000038 + MESH:D009055 + MIAA:0000038 + SCTID:21082005 + TADS:0000040 + TAO:0000547 + TAO:0000590 + TGMA:0000131 + VHOG:0000280 + VHOG:0000812 + Wikipedia:Mouth + XAO:0003029 + ZFA:0000547 + ZFA:0000590 + galen:Mouth + http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg mouth + + + + The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). + Wikipedia:Mouth + https://github.com/obophenotype/uberon/wiki/The-digestive-tract + @@ -104443,8 +154174,16 @@ + The orifice that connects the mouth to the exterior of the body. + FMA:59806 oral opening + + + + The orifice that connects the mouth to the exterior of the body. + https://github.com/obophenotype/uberon/wiki/The-digestive-tract + @@ -104481,8 +154220,77 @@ + Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present). + AAO:0000053 + AAO:0000960 + BSA:0000107 + CALOHA:TS-1315 + EFO:0001975 + EHDAA2:0001324 + EHDAA:6970 + EMAPA:17411 + EMAPA:18399 + EV:0100057 + FMA:20292 + HAO:0000669 + NCIT:C12421 + SCTID:181220002 + TAO:0001027 + TGMA:0000102 + VHOG:0000188 + WBbt:0005255 + XAO:0000126 + ZFA:0001027 oral cavity + + + + Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present). + ISBN:0073040584 + https://github.com/obophenotype/uberon/wiki/The-digestive-tract + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A section dividing a colon along a proximal-distal axis. + FMA:222905 + proximal-distal subdivision of colon + + + + + A section dividing a colon along a proximal-distal axis. + http://orcid.org/0000-0002-6601-2165 + @@ -104543,9 +154351,16 @@ - + The pair of anatomical structures comprised of a left lung and right lung. + FMA:68877 pair of lungs + + + + The pair of anatomical structures comprised of a left lung and right lung. + http://orcid.org/0000-0002-6601-2165 + @@ -104576,8 +154391,58 @@ + Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. + SCTID:272626006 + SPD:0000428 + TGMA:0001247 respiration organ + + + + Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. + GO:0007585 + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity. + AEO:0000184 + BTO:0000491 + EHDAA2_RETIRED:0003184 + ENVO:02000022 + FMA:9674 + galen:Excretion + excreta + + + + + A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity. + GO:0007588 + http://orcid.org/0000-0002-6601-2165 + @@ -104615,9 +154480,39 @@ - + A fluid that is composed of blood plasma and erythrocytes. + AAO:0000046 + BTO:0000089 + CALOHA:TS-0079 + EFO:0000296 + EHDAA2:0000176 + EHDAA:418 + EMAPA:16332 + ENVO:02000027 + EV:0100047 + FMA:9670 + GAID:965 + MA:0000059 + MESH:D001769 + MIAA:0000315 + NCIT:C12434 + TAO:0000007 + VHOG:0000224 + Wikipedia:Blood + XAO:0000124 + ZFA:0000007 + galen:Blood blood + + + + A fluid that is composed of blood plasma and erythrocytes. + FMA:9670 + Wikipedia:Blood + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/9 + @@ -104648,8 +154543,121 @@ + Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. + CARO:0000081 haemolymphatic fluid + + + + Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + The bone forming the forehead and roof of the eye orbit. + AAO:0000206 + EMAPA:19016 + FMA:52734 + GAID:226 + MA:0001466 + MESH:D005624 + NCIT:C32635 + SCTID:181793006 + VSAO:0000208 + Wikipedia:Frontal_bone + tetrapod frontal bone + + + + + The bone forming the forehead and roof of the eye orbit. + ISBN:0-683-40008-8 + MP:0000107 + PMID:7914451 + Wikipedia:Frontal_bone + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital. + FMA:24939 + NCIT:C32158 + SCTID:361831006 + Wikipedia:Atlanto-occipital_joint + ncithesaurus:Atlanto-occipital_Joint-Atlanto + atlanto-occipital joint + + + + + The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital. + Wikipedia:Atlanto-occipital_joint + @@ -104686,8 +154694,21 @@ + A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath. + BTO:0000051 + FMA:45087 + FMA:76715 + NCIT:C96299 + SCTID:361885006 + Wikipedia:Tendon_sheath tendon sheath + + + + A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath. + Wikipedia:Tendon_sheath + @@ -104718,8 +154739,101 @@ + Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + BILA:0000059 + BTO:0000128 + GAID:1294 + MESH:D036703 + OGEM:000006 + Wikipedia:Blastula blastula + + + + Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + Wikipedia:Blastula + + + + + + + + + + + + + + + + + + + + + + + + + + Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells. + BTO:0000271 + CALOHA:TS-0164 + EFO:0003038 + EMAPA:27375 + FMA:14984 + FMA:85388 + MA:0003194 + SCTID:362157008 + colonic mucosa + + + + + Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a duodenum [Automatically generated definition]. + BTO:0000367 + CALOHA:TS-0213 + EMAPA:27235 + FMA:14942 + MA:0003207 + SCTID:362146003 + duodenal mucosa + + + + + A mucosa that is part of a duodenum [Automatically generated definition]. + OBOL:automatic + @@ -104734,8 +154848,56 @@ + The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin. + BTO:0000503 + EMAPA:27181 + FMA:14919 gastric gland + + + + The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin. + MGI:anna + + + + + + + + + + + + + + + + + + + + + + + + + + Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach. + BTO:0000504 + CALOHA:TS-2235 + FMA:62973 + GAID:1166 + MESH:D010189 + pancreatic juice + + + + + Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach. + GO:0030157 + @@ -104760,8 +154922,17 @@ + The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity). + BTO:0000547 + FMA:45653 gut wall + + + + The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity). + http://orcid.org/0000-0002-6601-2165 + @@ -104792,8 +154963,55 @@ + Bone marrow in which the fat cells predominate in the meshes of the reticular network. + BTO:0000635 + FMA:74596 + SCTID:328639002 + SCTID:5023006 yellow bone marrow + + + + Bone marrow in which the fat cells predominate in the meshes of the reticular network. + http://medical-dictionary.thefreedictionary.com/Yellow+Marrow + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]. + BTO:0000640 + FMA:15052 + SCTID:266297002 + intestinal gland + + + + + A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]. + https://orcid.org/0000-0002-6601-2165 + @@ -104819,8 +155037,28 @@ + A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]. + AEO:0000199 + BTO:0000886 + CALOHA:TS-2031 + EHDAA2_RETIRED:0003234 + EV:0100382 + FMA:85355 + FMA:85358 + GAID:297 + MESH:D009092 + NCIT:C13166 + SCTID:361693009 + Wikipedia:Mucous_membrane + galen:Mucosa mucosa + + + + A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]. + Wikipedia:Mucous_membrane + @@ -104841,8 +155079,30 @@ + Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues. + EHDAA:3015 + EHDAA:3905 + EHDAA:3999 + EHDAA:4005 + EHDAA:6899 + EHDAA:6903 + EHDAA:6994 + EHDAA:8086 + EHDAA:9182 + EHDAA:9190 + EHDAA:9196 + EHDAA:9202 + FMA:45732 + NCIT:C74601 + Wikipedia:Parenchyma parenchyma + + + + Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues. + Wikipedia:Parenchyma + @@ -104867,8 +155127,20 @@ + A mucosa that is part of a pharynx [Automatically generated definition]. + BTO:0001047 + EMAPA:26957 + FMA:55031 + MA:0003143 + SCTID:362121003 pharyngeal mucosa + + + + A mucosa that is part of a pharynx [Automatically generated definition]. + OBOL:automatic + @@ -104912,8 +155184,27 @@ + The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]. + BTO:0001099 + CALOHA:TS-0076 + EFO:0000295 + EMAPA:36035 + EV:0100394 + FMA:83041 + GAID:1153 + MESH:D001755 + NCIT:C13739 + SCTID:308837009 + Wikipedia:Blastocyst blastocyst + + + + The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]. + GO:0001824 + Wikipedia:Blastocyst + @@ -104944,8 +155235,19 @@ + The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream. + BTO:0001160 + FMA:74595 + SCTID:328538003 + SCTID:75330005 red bone marrow + + + + The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream. + http://medical-dictionary.thefreedictionary.com/red+marrow + @@ -104965,8 +155267,24 @@ + Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated). + BTO:0001335 + EHDAA:129 + EHDAA:91 + EMAPA:16068 + FMA:83040 + NCIT:C33918 + SCTID:256965005 + Wikipedia:Syncytiotrophoblast syncytiotrophoblast + + + + Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated). + Wikipedia:Syncytiotrophoblast + http://embryology.med.unsw.edu.au/Notes/placenta5.htm + @@ -104980,9 +155298,27 @@ - + The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses. + AAO:0010670 + BTO:0001378 + EHDAA2:0002087 + EMAPA:17799 + FMA:52724 + GAID:836 + MA:0001103 + MESH:D008442 + SCTID:280211001 + VHOG:0001346 + Wikipedia:Maxillary_nerve maxillary nerve + + + + The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses. + MP:0009799 + Wikipedia:Maxillary_nerve + @@ -105007,8 +155343,18 @@ + A mucosa that is part of a respiratory airway. + BTO:0001390 + FMA:7471 + SCTID:660006 tracheal mucosa + + + + A mucosa that is part of a respiratory airway. + OBOL:automatic + @@ -105045,9 +155391,26 @@ - + The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. + AAO:0000307 + BILA:0000088 + BTO:0001369 + BTO:0001485 + EFO:0000801 + FMA:72954 + MA:0002888 + MAT:0000025 + MIAA:0000025 + VSAO:0000033 + XAO:0004042 musculature of body + + + + The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. + VSAO:0000033 + @@ -105085,9 +155448,20 @@ - + Tissue that surrounds the lens nucleus. + BTO:0001632 + CALOHA:TS-0542 + FMA:58970 + MESH:D007904 + SCTID:280626006 lens cortex + + + + Tissue that surrounds the lens nucleus. + http://www.thefreedictionary.com/lens+cortex + @@ -105125,9 +155499,60 @@ - + The core of the crystalline lens, surrounded by the cortex. + BTO:0001633 + FMA:58971 + MESH:D007907 + SCTID:280628007 lens nucleus + + + + The core of the crystalline lens, surrounded by the cortex. + BTO:0001633 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a colon [Automatically generated definition]. + BTO:0001709 + CALOHA:TS-0163 + EMAPA:18941 + FMA:17302 + MA:0003195 + SCTID:42978003 + TAO:0005128 + ZFA:0005128 + colonic epithelium + + + + + An epithelium that is part of a colon [Automatically generated definition]. + OBOL:automatic + @@ -105164,8 +155589,19 @@ + A gland in which the principal secretory cells are serous secreting cells. + BTO:0001837 + FMA:62889 + Wikipedia:Serous_gland serous gland + + + + A gland in which the principal secretory cells are serous secreting cells. + http://orcid.org/0000-0002-6601-2165 + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -105191,8 +155627,68 @@ + A mucosa that is part of a bronchus [Automatically generated definition]. + BTO:0001846 + FMA:62652 + SCTID:30802009 bronchial mucosa + + + + A mucosa that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A gland in which the principal secretory cells are mucus secreting cells. + AAO:0010601 + BTO:0001979 + FMA:62888 + Wikipedia:Mucous_gland + mucous gland + + + + + A gland in which the principal secretory cells are mucus secreting cells. + http://orcid.org/0000-0002-6601-2165 + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -105217,8 +155713,50 @@ + An anatomical wall that is part of an artery [Automatically generated definition]. + BTO:0002009 + FMA:14155 + galen:ArterialWall artery wall + + + + An anatomical wall that is part of an artery [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]. + BTO:0002501 + FMA:85273 + Wikipedia:Trabecula + trabecula + + + + + A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]. + GO:0060343 + Wikipedia:Trabecula + @@ -105243,8 +155781,24 @@ + A portion of organism substance that is produced by exocrine glands. + AEO:0001005 + BTO:0002977 + BTO:0002979 + EMAPA:36535 + FMA:9675 + MA:0002504 + MESH:D012634 + NCIT:C34062 + galen:Secretion secretion of exocrine gland + + + + A portion of organism substance that is produced by exocrine glands. + http://orcid.org/0000-0002-6601-2165 + @@ -105264,11 +155818,33 @@ - - - + Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. + AAO:0010839 + AEO:0000004 + BILA:0000004 + CALOHA:TS-2101 + CARO:0000004 + EHDAA2:0003004 + EMAPA:35178 + FMA:9669 + HAO:0000004 + MA:0002450 + NCIT:C13236 + SPD:0000008 + TAO:0001487 + TGMA:0001824 + VHOG:0001726 + XAO:0004001 + ZFA:0001487 + galen:BodySubstance organism substance + + + + Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. + http://orcid.org/0000-0001-9114-8737 + @@ -105282,11 +155858,28 @@ - - - + Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. + AAO:0010110 + AEO:0000005 + BILA:0000005 + CARO:0000005 + EHDAA2:0003005 + FMA:5897 + HAO:0000005 + NCIT:C94478 + TAO:0001668 + TGMA:0001825 + VHOG:0001728 + XAO:0003190 + ZFA:0001643 anatomical space + + + + Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. + http://orcid.org/0000-0001-9114-8737 + @@ -105296,11 +155889,25 @@ - - - + Anatomical entity that has mass. + AAO:0010264 + AEO:0000006 + BILA:0000006 + CARO:0000006 + EHDAA2:0003006 + FMA:67165 + HAO:0000006 + TAO:0001836 + TGMA:0001826 + VHOG:0001721 material anatomical entity + + + + Anatomical entity that has mass. + http://orcid.org/0000-0001-9114-8737 + @@ -105309,11 +155916,25 @@ - - - + Anatomical entity that has no mass. + AAO:0010265 + AEO:0000007 + BILA:0000007 + CARO:0000007 + EHDAA2:0003007 + FMA:67112 + HAO:0000007 + TAO:0001835 + TGMA:0001827 + VHOG:0001727 immaterial anatomical entity + + + + Anatomical entity that has no mass. + http://orcid.org/0000-0001-9114-8737 + @@ -105333,12 +155954,40 @@ - - - - + Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. + AAO:0000007 + AEO:0000011 + BILA:0000011 + BIRNLEX:14 + BSA:0000049 + CALOHA:TS-2088 + CARO:0000011 + EHDAA2:0003011 + EHDAA:392 + EMAPA:16103 + EV:0100000 + FMA:7149 + HAO:0000011 + MA:0000003 + NCIT:C12919 + SCTID:278195005 + TAO:0001439 + TGMA:0001831 + VHOG:0001725 + WBbt:0005746 + WBbt:0005763 + Wikipedia:Organ_system + XAO:0003002 + ZFA:0001439 + galen:AnatomicalSystem anatomical system + + + + Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. + CARO:0000011 + @@ -105346,11 +155995,77 @@ - - - + Anatomical structure that is an individual member of a species and consists of more than one cell. + AAO:0010026 + AEO:0000191 + BILA:0000012 + BIRNLEX:18 + BSA:0000038 + BTO:0000042 + CARO:0000012 + EFO:0002906 + EHDAA2:0003103 + EHDAA2:0003191 + EHDAA:1 + EMAPA:25765 + EV:0100016 + FMA:256135 + HAO:0000012 + NCIT:C13041 + SCTID:243928005 + TADS:0000001 + TAO:0001094 + TGMA:0001832 + VHOG:0000671 + WBbt:0007833 + Wikipedia:Multi-cellular_organism + XAO:0003004 + ZFA:0001094 + galen:Organism + ncithesaurus:Whole_Organism multicellular organism + + + + Anatomical structure that is an individual member of a species and consists of more than one cell. + CARO:0000012 + Wikipedia:Multi-cellular_organism + http://orcid.org/0000-0001-9114-8737 + + + + + + + + + + + + + + + Multi-tissue structure that is part of a compound organ. + AAO:0010017 + AEO:0000019 + BILA:0000019 + CARO:0000019 + EHDAA2:0003019 + HAO:0000019 + TAO:0001489 + TGMA:0001835 + XAO:0003039 + ZFA:0001489 + compound organ component + + + + + Multi-tissue structure that is part of a compound organ. + CARO:0000019 + http://orcid.org/0000-0001-9114-8737 + @@ -105375,9 +156090,37 @@ - + The organs and associated structures associated with bearing offspring in a female animal. + BTO:0000083 + CALOHA:TS-1303 + EFO:0000969 + EHDAA2:0000506 + EHDAA:8116 + EMAPA:17959 + EV:0100110 + FMA:45663 + GAID:364 + HAO:0000324 + MA:0000381 + MESH:D005836 + MIAA:0000028 + NCIT:C12402 + SCTID:361386004 + TGMA:0000635 + VHOG:0000726 + Wikipedia:Female_genitalia + WikipediaCategory:Female_reproductive_system + XAO:0000156 female reproductive system + + + + The organs and associated structures associated with bearing offspring in a female animal. + MP:0001119 + Wikipedia:Female_genitalia + http://orcid.org/0000-0002-6601-2165 + @@ -105391,11 +156134,40 @@ - - - + Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. + AAO:0010053 + AEO:0000032 + BILA:0000032 + BIRNLEX:7 + CALOHA:TS-2084 + CARO:0000032 + EFO:0000808 + EHDAA2:0003032 + EMAPA:36031 + FMA:7153 + HAO:0000032 + MA:0002433 + MAT:0000293 + MESH:D001829 + MIAA:0000293 + NCIT:C32221 + TAO:0001308 + TGMA:0001840 + VHOG:0001758 + Wikipedia:Body_part + XAO:0003013 + ZFA:0001308 + galen:BodyPart organism subdivision + + + + Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. + CARO:0000032 + CARO:DOS + http://orcid.org/0000-0001-9114-8737 + @@ -105403,11 +156175,26 @@ - - - + Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. + AAO:0010268 + AEO:0000040 + BILA:0000040 + CARO:0000040 + EHDAA2:0003040 + FMA:63863 + HAO:0000040 + TAO:0000382 + TGMA:0001841 + XAO:0003162 + ZFA:0000382 acellular anatomical structure + + + + Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. + http://orcid.org/0000-0001-9114-8737 + @@ -105415,11 +156202,16 @@ - - - + Anatomical group whose component anatomical structures lie in close proximity to each other. + VHOG:0001737 anatomical cluster + + + + Anatomical group whose component anatomical structures lie in close proximity to each other. + FBbt:00007277 + @@ -105444,8 +156236,34 @@ + A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis. + AAO:0010020 + AEO:0000042 + BILA:0000042 + CALOHA:TS-2119 + CARO:0000042 + EHDAA2:0003042 + EHDAA:46 + FMA:85537 + HAO:0000042 + NCIT:C34055 + SCTID:314908006 + TAO:0000020 + TGMA:0001843 + VHOG:0000292 + XAO:0004005 + ZFA:0000020 + see also conceptus extraembryonic component in EHDAA2. extraembryonic structure + + + + A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis. + CARO:DOS + http://orcid.org/0000-0001-9114-8737 + https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279 + @@ -105465,11 +156283,36 @@ - - - + Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. + AAO:0000607 + AAO:0010054 + AEO:0000043 + BILA:0000043 + BIRNLEX:19 + CALOHA:TS-2090 + CARO:0000043 + EHDAA2:0003043 + EMAPA:35868 + FMA:9637 + HAO:0000043 + MA:0003002 + MESH:D014024 + NCIT:C12801 + TAO:0001477 + TGMA:0001844 + VHOG:0001757 + WBbt:0005729 + XAO:0003040 + ZFA:0001477 + galen:Tissue tissue + + + + Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. + CARO:0000043 + @@ -105483,11 +156326,27 @@ - - - + Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. + AAO:0010048 + AEO:0000055 + BILA:0000055 + CARO:0000055 + EHDAA2:0003055 + HAO:0000055 + TAO:0001488 + TGMA:0001847 + VHOG:0001762 + XAO:0003037 + ZFA:0001488 multi-tissue structure + + + + Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. + CARO:0000055 + http://orcid.org/0000-0001-9114-8737 + @@ -105538,8 +156397,38 @@ + Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. + AAO:0000144 + AAO:0010055 + AEO:0000066 + BILA:0000066 + BTO:0000416 + CALOHA:TS-0288 + CARO:0000066 + EHDAA2:0003066 + EMAPA:32738 + FMA:9639 + GAID:402 + HAO:0000066 + MA:0003060 + MESH:D004848 + NCIT:C12710 + SCTID:31610004 + TAO:0001486 + VHOG:0000387 + Wikipedia:Epithelium + XAO:0003045 + ZFA:0001486 + Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it? epithelium + + + + Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. + Wikipedia:Epithelium + http://orcid.org/0000-0001-9114-8737 + @@ -105548,8 +156437,28 @@ + Unilaminar epithelium that consists of a single layer of cuboidal cells. + AAO:0010064 + AEO:0000067 + BILA:0000067 + CARO:0000067 + EHDAA2:0003067 + FMA:45566 + HAO:0000067 + NCIT:C33553 + TAO:0001497 + Wikipedia:Simple_cuboidal_epithelium + XAO:0004009 + ZFA:0001497 simple cuboidal epithelium + + + + Unilaminar epithelium that consists of a single layer of cuboidal cells. + Wikipedia:Simple_cuboidal_epithelium + http://orcid.org/0000-0001-9114-8737 + @@ -105558,8 +156467,30 @@ + Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]. + AAO:0010063 + AEO:0000068 + BILA:0000068 + CARO:0000068 + EHDAA2_RETIRED:0003068 + FMA:45567 + HAO:0000068 + NCIT:C33552 + SCTID:32210007 + TAO:0001496 + Wikipedia:Simple_columnar_epithelium + XAO:0004008 + ZFA:0001496 simple columnar epithelium + + + + Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]. + FMA:FMA + Wikipedia:Simple_columnar_epithelium + http://orcid.org/0000-0001-9114-8737 + @@ -105567,8 +156498,31 @@ + Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]. + AAO:0010059 + AEO:0000069 + BILA:0000069 + BTO:0002074 + CARO:0000069 + EHDAA2:0003069 + FMA:45562 + HAO:0000069 + NCIT:C33622 + SCTID:309044005 + TAO:0001494 + Wikipedia:Stratified_epithelium + XAO:0004006 + ZFA:0001494 multilaminar epithelium + + + + Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]. + FMA:FMA + Wikipedia:Stratified_epithelium + http://orcid.org/0000-0001-9114-8737 + @@ -105588,8 +156542,30 @@ + Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]. + AAO:0010066 + AEO:0000070 + BILA:0000070 + BTO:0002073 + CARO:0000070 + EHDAA2:0003070 + FMA:45565 + HAO:0000070 + NCIT:C13178 + TAO:0001498 + Wikipedia:Simple_squamous_epithelium + XAO:0004010 + ZFA:0001498 simple squamous epithelium + + + + Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]. + FMA:45565 + Wikipedia:Simple_squamous_epithelium + http://orcid.org/0000-0001-9114-8737 + @@ -105597,8 +156573,25 @@ + Epithelium that consists of epithelial cells not arranged in one ore more layers. + AAO:0010057 + AEO:0000071 + BILA:0000071 + CARO:0000071 + EHDAA2:0003071 + FMA:61741 + HAO:0000071 + TAO:0001493 + XAO:0004004 + ZFA:0001493 atypical epithelium + + + + Epithelium that consists of epithelial cells not arranged in one ore more layers. + http://orcid.org/0000-0001-9114-8737 + @@ -105623,8 +156616,27 @@ + Compound organ that contains one or more macroscopic anatomical spaces. + AAO:0010016 + AEO:0000072 + BILA:0000072 + CARO:0000072 + EHDAA2:0003072 + FMA:55671 + HAO:0000072 + TAO:0001490 + TGMA:0001857 + VHOG:0001730 + XAO:0003165 + ZFA:0001490 cavitated compound organ + + + + Compound organ that contains one or more macroscopic anatomical spaces. + http://orcid.org/0000-0001-9114-8737 + @@ -105632,8 +156644,72 @@ + Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]. + AAO:0010062 + AEO:0000073 + BILA:0000073 + BTO:0002073 + CARO:0000073 + EHDAA2:0003073 + FMA:45561 + HAO:0000073 + NCIT:C33554 + SCTID:309043004 + TAO:0001495 + XAO:0004007 + ZFA:0001495 unilaminar epithelium + + + + Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]. + FMA:45561 + http://orcid.org/0000-0001-9114-8737 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water. + CALOHA:TS-2144 + ENVO:02000040 + FMA:66938 + GAID:1164 + MESH:D009093 + NCIT:C13259 + Wikipedia:Mucus + galen:Mucus + mucus + + + + + Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water. + Wikipedia:Mucus + @@ -105659,8 +156735,20 @@ + Subdivision of trunk that lies between the head and the abdomen. + EMAPA:35862 + FMA:259209 + MA:0000022 + SCTID:302551006 + Wikipedia:Thorax thoracic segment of trunk + + + + Subdivision of trunk that lies between the head and the abdomen. + http://orcid.org/0000-0002-6601-2165 + @@ -105680,8 +156768,29 @@ + The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column. + BTO:0000020 + CALOHA:TS-0001 + EFO:0000968 + EMAPA:35102 + EV:0100011 + FMA:9577 + GAID:16 + MA:0000029 + MAT:0000298 + MESH:D000005 + MIAA:0000298 + SCTID:302553009 + Wikipedia:Abdomen + galen:Abdomen abdomen + + + + The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column. + http://orcid.org/0000-0002-6601-2165 + @@ -105716,8 +156825,43 @@ + Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + AAO:0011035 + AEO:0000169 + BILA:0000056 + BSA:0000039 + BTO:0000379 + CALOHA:TS-0229 + EFO:0001367 + EHDAA2:0000002 + EHDAA2_RETIRED:0003236 + EHDAA:38 + EMAPA:16039 + FMA:69068 + GAID:963 + MAT:0000226 + MESH:D004622 + MIAA:0000019 + NCIT:C28147 + OGEM:000001 + SCTID:57991002 + VHOG:0001766 + Wikipedia:Embryo + XAO:0000113 + ZFA:0000103 + http://neurolex.org/wiki/Category:Embryonic_organism embryo + + + + Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + BTO:0000379 + FB:FBrf0039741 + FB:FBrf0041814 + GO:0009790 + Wikipedia:Embryo + @@ -105731,8 +156875,31 @@ + A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. + AAO:0000480 + BILA:0000035 + BTO:0000556 + EMAPA:36033 + FMA:69069 + GAID:1303 + MESH:D005855 + NCIT:C12950 + NCIT:C54105 + TAO:0001122 + VHOG:0001223 + Wikipedia:Germ_layer + XAO:0003011 + ZFA:0001122 + Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest] germ layer + + + + A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. + Wikipedia:Germ_layer + https://github.com/obophenotype/uberon/issues/203 + @@ -105752,8 +156919,36 @@ + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. + AAO:0000137 + BILA:0000036 + BTO:0000315 + CALOHA:TS-0216 + EFO:0000414 + EHDAA2:0000428 + EMAPA:16069 + EV:0100003 + FMA:69070 + GAID:1304 + MAT:0000155 + MAT:0000173 + MESH:D004475 + MIAA:0000173 + NCIT:C12703 + SCTID:362851007 + TAO:0000016 + VHOG:0000153 + Wikipedia:Ectoderm + XAO:0000001 + ZFA:0000016 ectoderm + + + + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. + Wikipedia:Ectoderm + @@ -105773,8 +156968,35 @@ + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. + AAO:0000139 + BILA:0000038 + BTO:0000800 + CALOHA:TS-0273 + EFO:0002545 + EHDAA2:0000436 + EMAPA:16062 + EV:0100005 + FMA:69071 + GAID:1305 + MAT:0000175 + MESH:D004707 + MIAA:0000175 + NCIT:C12706 + SCTID:362855003 + TAO:0000017 + VHOG:0000154 + Wikipedia:Endoderm + XAO:0000090 + ZFA:0000017 endoderm + + + + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. + Wikipedia:Endoderm + @@ -105794,8 +157016,38 @@ + The middle germ layer of the embryo, between the endoderm and ectoderm. + AAO:0000304 + BILA:0000037 + BTO:0000839 + CALOHA:TS-0623 + EFO:0001981 + EHDAA2:0001128 + EHDAA:124 + EHDAA:160 + EHDAA:183 + EMAPA:16083 + EV:0100006 + FMA:69072 + GAID:522 + MAT:0000174 + MESH:D008648 + MIAA:0000174 + NCIT:C12750 + SCTID:362854004 + TAO:0000041 + VHOG:0000152 + Wikipedia:Mesoderm + XAO:0000050 + ZFA:0000041 mesoderm + + + + The middle germ layer of the embryo, between the endoderm and ectoderm. + Wikipedia:Mesoderm + @@ -105821,8 +157073,84 @@ + Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. + BTO:0004224 + EHDAA2:0001929 + EMAPA:16263 + FMA:295846 + NCIT:C34306 + TAO:0001290 + TGMA:0000135 + Wikipedia:Stomodeum + XAO:0000269 + ZFA:0001290 stomodeum + + + + Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. + Wikipedia:Stomodeum + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/326 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract. + AAO:0011087 + EHDAA2:0000121 + EMAPA:25038 + NCIT:C34278 + TAO:0000066 + VHOG:0000139 + Wikipedia:Proctodeum + XAO:0001019 + ZFA:0000066 + proctodeum + + + + + Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract. + ZFA:0000066 + https://github.com/obophenotype/uberon/issues/685 + https://sourceforge.net/p/fbbtdv/tickets/52 + @@ -105855,9 +157183,39 @@ - + An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium. + AAO:0000579 + ANISEED:1235297 + BTO:0001307 + CALOHA:TS-0980 + EFO:0000837 + EHDAA2:0001915 + EHDAA:2993 + EMAPA:17021 + EV:0100070 + FMA:7148 + GAID:293 + MA:0000353 + MAT:0000051 + MESH:D013270 + MIAA:0000051 + NCIT:C12391 + SCTID:181246003 + TAO:0002121 + VHOG:0000408 + Wikipedia:Stomach + XAO:0000128 + galen:Stomach stomach + + + + An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium. + ISBN:0073040584 + Wikipedia:Stomach + https://orcid.org/0000-0002-6601-2165 + @@ -105879,9 +157237,37 @@ - + The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation. + AAO:0010213 + BTO:0000135 + CALOHA:TS-0046 + EFO:0000265 + EMAPA:18601 + EV:0100027 + FMA:3734 + GAID:469 + MA:0000062 + MAT:0000035 + MESH:D001011 + MIAA:0000035 + NCIT:C12669 + SCTID:181298001 + VHOG:0001523 + Wikipedia:Aorta + XAO:0003010 + galen:Aorta aorta + + + + The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation. + ISBN:0-683-40008-8 + MESH:A07.231.114.056 + MP:0000272 + Wikipedia:Aorta + http://orcid.org/0000-0002-6601-2165 + @@ -105933,9 +157319,40 @@ - + A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. + AAO:0010210 + BILA:0000020 + BTO:0000562 + CALOHA:TS-0445 + EFO:0000815 + EHDAA2:0000738 + EHDAA:420 + EMAPA:16105 + EV:0100018 + FMA:7088 + GAID:174 + MA:0000072 + MAT:0000036 + MESH:D006321 + MIAA:0000036 + NCIT:C12727 + SCTID:302509004 + TAO:0000114 + VHOG:0000276 + Wikipedia:Heart + XAO:0000064 + ZFA:0000114 + galen:Heart + Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 heart + + + + A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. + Wikipedia:Heart + http://orcid.org/0000-0002-6601-2165 + @@ -105968,14 +157385,41 @@ + + + Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. + AAO:0010279 + CALOHA:TS-1301 + EFO:0002969 + EHDAA2:0002224 + EMAPA:35306 + EV:0100128 + FMA:9668 + GAID:439 + MA:0000012 + MESH:D004703 + NCIT:C12705 + SCTID:278876000 + TAO:0001158 + VHOG:0000098 + Wikipedia:Endocrine_system + XAO:0000158 + ZFA:0001158 endocrine system + + + + Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. + NLM:endocrine+system + Wikipedia:Endocrine_system + @@ -106020,9 +157464,49 @@ - + The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. + AAO:0010478 + ABA:Brain + BAMS:Br + BAMS:Brain + BILA:0000135 + BIRNLEX:796 + BTO:0000142 + CALOHA:TS-0095 + DHBA:10155 + EFO:0000302 + EHDAA2:0000183 + EHDAA:2641 + EHDAA:6485 + EMAPA:16894 + EV:0100164 + FMA:50801 + GAID:571 + HBA:4005 + MA:0000168 + MAT:0000098 + MBA:8 + MBA:997 + MESH:D001921 + MIAA:0000098 + NCIT:C12439 + PBA:3999 + SCTID:258335003 + TAO:0000008 + VHOG:0000157 + Wikipedia:Brain + XAO:0000010 + ZFA:0000008 + galen:Brain brain + + + + The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. + Wikipedia:Brain + https://github.com/obophenotype/uberon/issues/300 + @@ -106047,8 +157531,16 @@ + Any thin layer or plate. + Wikipedia:Lamina_of_the_vertebral_arch lamina + + + + Any thin layer or plate. + Wikipedia:Lamina_of_the_vertebral_arch + @@ -106073,9 +157565,23 @@ - + The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]. + BAMS:cern + FMA:5859 + NCIT:C32299 + NLXANAT:20090207 + SCTID:360497008 + Wikipedia:Cervical_nerves + neuronames:2351 + Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP] nerve of cervical vertebra + + + + The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]. + Wikipedia:Cervical_nerves + @@ -106100,6 +157606,8 @@ + MAT:0000204 + MIAA:0000204 head sensillum @@ -106176,9 +157684,36 @@ - + The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure. + AAO:0010344 + BTO:0000286 + CALOHA:TS-0171 + EFO:0000377 + EHDAA2:0000316 + EHDAA:10199 + EMAPA:17161 + EV:0100341 + FMA:58238 + GAID:892 + MA:0000266 + MESH:D003315 + NCIT:C12342 + SCTID:181162001 + TAO:0000640 + VHOG:0000164 + Wikipedia:Cornea + XAO:0000180 + ZFA:0000640 cornea + + + + The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure. + ISBN:0-683-40008-8 + MESH:A09.371.060.217 + MP:0001312 + @@ -106211,9 +157746,36 @@ - + A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina. + AAO:0010348 + BTO:0000723 + CALOHA:TS-0545 + EHDAA:9057 + EMAPA:17838 + EV:0100343 + FMA:58241 + MA:0000275 + MAT:0000141 + MESH:D007908 + MIAA:0000141 + NCIT:C12743 + RETIRED_EHDAA2:0000975 + SCTID:181169005 + TAO:0000035 + VHOG:0000169 + Wikipedia:Lens_(anatomy) + XAO:0000008 + ZFA:0000035 + The lens is avascular and nourished by diffusion from the aqueous and vitreous humors. lens of camera-type eye + + + + A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina. + Wikipedia:Lens_(anatomy) + http://orcid.org/0000-0002-6601-2165 + @@ -106258,9 +157820,43 @@ - + The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + AAO:0010352 + BAMS:R + BIRNLEX:1153 + BTO:0001175 + CALOHA:TS-0865 + EFO:0000832 + EHDAA2:0001627 + EHDAA:4757 + EMAPA:17168 + EV:0100348 + FMA:58301 + GAID:755 + MA:0000276 + MAT:0000142 + MBA:304325711 + MESH:D012160 + MIAA:0000142 + NCIT:C12343 + NIFSTD_RETIRED:birnlex_1156 + SCTID:181171005 + TAO:0000152 + VHOG:0000229 + Wikipedia:Retina + XAO:0000009 + ZFA:0000152 + neuronames:1862 + Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods retina + + + + The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + Wikipedia:Retina + ZFIN:curator + @@ -106292,9 +157888,25 @@ - + An organ that detects light. + BILA:0000017 + BTO:0000439 + CALOHA:TS-0309 + EFO:0000827 + EV:0100336 + GAID:69 + MAT:0000140 + MESH:D005123 + MIAA:0000140 + Wikipedia:Eye eye + + + + An organ that detects light. + https://orcid.org/0000-0002-6601-2165 + @@ -106309,8 +157921,20 @@ + The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells. + BTO:0001922 + HAO:0000666 + MAT:0000143 + MIAA:0000143 + Wikipedia:Ommatidium ommatidium + + + + The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells. + PMID:21062451 + @@ -106336,8 +157960,31 @@ + An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column. + AEO:0000108 + BTO:0000420 + CALOHA:TS-2045 + EFO:0000967 + EHDAA2:0003108 + EMAPA:35587 + FMA:7155 + GAID:86 + MA:0000024 + MAT:0000297 + MESH:D009333 + MIAA:0000297 + NCIT:C13063 + SCTID:302550007 + Wikipedia:Neck + galen:Neck neck + + + + An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column. + http://orcid.org/0000-0002-6601-2165 + @@ -106407,8 +158054,31 @@ + The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion). + BTO:0001791 + CALOHA:TS-2081 + EFO:0001980 + EV:0100044 + FMA:9583 + GAID:360 + MA:0000433 + MESH:D010994 + NCIT:C12469 + SCTID:181609007 + VHOG:0000394 + Wikipedia:Pleura pleura + + + + The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion). + ISBN:0-683-40008-8 + MP:0010820 + UBERON:cjm + Wikipedia:Pulmonary_pleurae + https://github.com/obophenotype/uberon/issues/1231 + @@ -106437,8 +158107,39 @@ + Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. + AEO:0000182 + BTO:0001686 + CALOHA:TS-2023 + EFO:0000948 + EMAPA:35456 + FMA:7490 + GAID:102 + MA:0000319 + MAT:0000188 + MESH:D007596 + MIAA:0000188 + NCIT:C13044 + RETIRED_EHDAA2:0003182 + SCTID:302536002 + TAO:0000367 + VHOG:0001276 + VSAO:0000101 + Wikipedia:Joint + XAO:0000171 + ZFA:0001596 + galen:Joint skeletal joint + + + + Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. + GO_REF:0000034 + VSAO:0000101 + Wikipedia:Joint + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -106476,9 +158177,38 @@ - + The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. + BAMS:PONS + BAMS:Pons + BIRNLEX:733 + BM:Pons + BTO:0001101 + CALOHA:TS-0813 + DHBA:10661 + EFO:0001394 + EHDAA2:0004394 + EMAPA:17563 + EV:0100253 + FMA:67943 + GAID:578 + HBA:9131 + MA:0000204 + MAT:0000115 + MBA:771 + MESH:D011149 + MIAA:0000115 + NCIT:C12511 + SCTID:279103004 + VHOG:0001176 + Wikipedia:Pons pons + + + + The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. + VHOG:0001176 + @@ -106521,15 +158251,46 @@ + + - + Anatomical system that has as its parts the organs concerned with reproduction. + AAO:0010258 + BILA:0000103 + BTO:0000081 + CALOHA:TS-1318 + EFO:0000809 + EHDAA2:0001603 + EHDAA:5923 + EMAPA:17381 + EV:0100100 + FMA:7160 + GAID:363 + HAO:0000374 + HAO:0000895 + MA:0000326 + MIAA:0000305 + NCIT:C12841 + SCTID:278875001 + TAO:0000632 + VHOG:0000182 + WBbt:0005747 + Wikipedia:Reproductive_system + XAO:0000142 + ZFA:0000632 reproductive system + + + + Anatomical system that has as its parts the organs concerned with reproduction. + Wikipedia:Reproductive_system + @@ -106566,8 +158327,36 @@ + Reproductive organ that produces and releases eggs (ovary) or sperm (testis). + AAO:0000213 + BILA:0000123 + BSA:0000079 + BTO:0000534 + EMAPA:17383 + FMA:18250 + GAID:368 + HAO:0000379 + MA:0002420 + MESH:D006066 + NCIT:C12725 + SCTID:304623008 + TAO:0000413 + VHOG:0000397 + WBbt:0005175 + Wikipedia:Gonad + XAO:0003146 + ZFA:0000413 gonad + + + + Reproductive organ that produces and releases eggs (ovary) or sperm (testis). + ISBN:0140512888 + Wikipedia:Gonad + ZFA:0000413 + ZFIN:curator + @@ -106600,9 +158389,39 @@ - + The gonad of a female organism which contains germ cells. + AAO:0000371 + BILA:0000125 + BSA:0000080 + BTO:0000975 + CALOHA:TS-0730 + EFO:0000973 + EHDAA2:0001360 + EHDAA:8124 + EMAPA:17962 + EV:0100111 + FMA:7209 + GAID:367 + MA:0000384 + MESH:D010053 + MIAA:0000125 + NCIT:C12404 + SCTID:181464007 + TAO:0000403 + VHOG:0000251 + Wikipedia:Ovary + XAO:0000258 + ZFA:0000403 ovary + + + + The gonad of a female organism which contains germ cells. + ISBN:0-683-40008-8 + MP:0001126 + Wikipedia:Ovary + @@ -106640,9 +158459,35 @@ - + The outer epithelial layer of the skin that is superficial to the dermis. + AAO:0000143 + BTO:0000404 + CALOHA:TS-0283 + EFO:0000954 + EMAPA:17528 + EV:0100153 + FMA:70596 + GAID:932 + MA:0000153 + MAT:0000154 + MESH:D004817 + MIAA:0000154 + NCIT:C12708 + SCTID:361694003 + TAO:0000105 + VHOG:0000077 + Wikipedia:Epidermis_(skin) + XAO:0000028 + ZFA:0000105 skin epidermis + + + + The outer epithelial layer of the skin that is superficial to the dermis. + ISBN:0073040584 + http://orcid.org/0000-0002-6601-2165 + @@ -106690,15 +158535,45 @@ + + - + Functional system which consists of structures involved in respiration. + AAO:0000541 + BTO:0000203 + CALOHA:TS-1319 + EFO:0000804 + EHDAA2:0001604 + EHDAA:2203 + EMAPA:16727 + EV:0100036 + FMA:7158 + GAID:78 + MA:0000327 + MAT:0000030 + MESH:D012137 + MIAA:0000030 + NCIT:C12779 + SCTID:278197002 + TAO:0000272 + VHOG:0000202 + Wikipedia:Respiratory_system + XAO:0000117 + ZFA:0000272 respiratory system + + + + Functional system which consists of structures involved in respiration. + Wikipedia:Respiratory_system + http://orcid.org/0000-0002-6601-2165 + @@ -106719,8 +158594,17 @@ + An airway through which respiratory air passes in organisms. + SCTID:361380005 + Wikipedia:Trachea respiratory airway + + + + An airway through which respiratory air passes in organisms. + Wikipedia:Trachea + @@ -106755,15 +158639,118 @@ + + - + Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. + AAO:0000129 + BILA:0000082 + BTO:0000058 + CALOHA:TS-1293 + EFO:0000793 + FMA:7152 + GAID:278 + MA:0002431 + MAT:0000018 + MESH:D004064 + MIAA:0000018 + SCTID:278859004 + TADS:0000170 + TAO:0000339 + WBbt:0005748 + Wikipedia:Digestive_system + XAO:0000125 + ZFA:0000339 + galen:DigestiveSystem + ncithesaurus:Digestive_System digestive system + + + + Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. + FB:gg + NLM:alimentary+system + Wikipedia:Digestive_system + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. + AAO:0010257 + BILA:0000015 + BTO:0001244 + BTO:0003092 + CALOHA:TS-1323 + EFO:0000803 + EHDAA2:0001601 + EHDAA:5901 + EMAPA:17366 + EV:0100095 + FMA:7159 + GAID:391 + MA:0000325 + MAT:0000027 + MESH:D014551 + MIAA:0000027 + NCIT:C12413 + SCTID:362204003 + TADS:0000162 + TAO:0000163 + VHOG:0000723 + WBbt:0005736 + Wikipedia:Excretory_system + XAO:0000143 + ZFA:0000163 + galen:UrinaryTract + EDITOR_NOTE In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here + renal system + + + + + The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. + DOI:10.1371/journal.pone.0099864 + GO:0072001 + @@ -106792,15 +158779,27 @@ + + - + Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. + AAO:0000959 + CALOHA:TS-2103 + VHOG:0001248 + Wikipedia:Circulatory_system circulatory system + + + + Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. + Wikipedia:Circulatory_system + @@ -106826,9 +158825,41 @@ - + Portion of connective tissue composed of adipocytes enmeshed in areolar tissue. + AAO:0000001 + AEO:000020 + BTO:0001487 + CALOHA:TS-0013 + EFO:0000790 + EHDAA2:0003120 + EMAPA:35112 + EV:0100381 + FMA:20110 + GAID:920 + MA:0000009 + MAT:0000015 + MESH:D000273 + MIAA:0000015 + NCIT:C12472 + SCTID:55603005 + TAO:0002134 + VHOG:0001284 + Wikipedia:Adipose_tissue + XAO:0003049 + ZFA:0005345 + galen:FattyTissue adipose tissue + + + + Portion of connective tissue composed of adipocytes enmeshed in areolar tissue. + MESH:A10.165.114 + MGI:cwg + MP:0000003 + Wikipedia:Adipose_tissue + http://orcid.org/0000-0002-6601-2165 + @@ -106848,8 +158879,27 @@ + A subdivision of the muscular system corresponding to a subdisivision of an organism. + BTO:0000887 + EFO:0001949 + EMAPA:35577 + FMA:32558 + MA:0000165 + NCIT:C13056 + TAO:0000548 + VSAO:0005038 + WBbt:0005737 + Wikipedia:Muscular_system + ZFA:0000548 musculature + + + + A subdivision of the muscular system corresponding to a subdisivision of an organism. + Wikipedia:Muscular_system + https://orcid.org/0000-0002-6601-2165 + @@ -106895,15 +158945,54 @@ + + - + The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. + AAO:0000324 + BILA:0000079 + BIRNLEX:844 + BTO:0001484 + CALOHA:TS-1313 + EFO:0000802 + EHDAA2:0001246 + EHDAA:826 + EMAPA:16469 + EV:0100162 + FMA:7157 + GAID:466 + MA:0000016 + MAT:0000026 + MESH:D009420 + MIAA:0000026 + NCIT:C12755 + SCTID:278196006 + TAO:0000396 + VHOG:0000402 + WBbt:0005735 + Wikipedia:Nervous_system + XAO:0000177 + ZFA:0000396 + neuronames:3236 nervous system + + + + The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. + BIRNLEX:844 + ISBN:0-14-051288-8 + ISBN:3110148986 + NLM:nervous+system + WB:rynl + Wikipedia:Nervous_system + ZFIN:curator + @@ -106930,9 +159019,42 @@ - + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. + AAO:0000090 + BAMS:CNS + BILA:0000080 + BIRNLEX:1099 + BTO:0000227 + CALOHA:TS-0150 + EFO:0000908 + EHDAA2:0000225 + EHDAA:828 + EMAPA:16470 + EMAPA:16754 + EV:0100163 + FMA:55675 + GAID:570 + MA:0000167 + MAT:0000457 + MESH:D002490 + NCIT:C12438 + SCTID:278199004 + TAO:0000012 + VHOG:0000293 + Wikipedia:Central_nervous_system + XAO:0000215 + ZFA:0000012 + neuronames:854 central nervous system + + + + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. + GO:0021551 + http://www.frontiersinzoology.com/content/7/1/29 + https://sourceforge.net/p/geneontology/ontology-requests/11422/ + @@ -106952,9 +159074,50 @@ - + An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures. + AAO:0011070 + AEO:0000137 + BAMS:n + BIRNLEX:1615 + BSA:0000098 + BTO:0000925 + BTO:0001027 + CALOHA:TS-0772 + EHDAA2:0003137 + EHDAA:2851 + EHDAA:3776 + EHDAA:4657 + EMAPA:32808 + EMAPA:32815 + EV:0100371 + FMA:65132 + FMA:65239 + GAID:747 + GAID:758 + MA:0000217 + MA:0000228 + MESH:D010525 + NCIT:C12466 + NCIT:C12768 + NLX:147826 + SCTID:244457007 + SCTID:256864008 + TAO:0007009 + VHOG:0000901 + Wikipedia:Nervous_system + XAO:0000204 + XAO:0003047 + ZFA:0007009 + galen:Nerve nerve + + + + An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures. + FBbt:00005105 + http://orcid.org/0000-0002-6601-2165 + @@ -106968,8 +159131,20 @@ + A nerve that transmits from sensory receptors on the surface of the body to the central nervous system. + AEO:0000201 + EHDAA2:0003200 + FMA:5868 + Wikipedia:Sensory_nerve sensory nerve + + + + A nerve that transmits from sensory receptors on the surface of the body to the central nervous system. + UBERON:cjm + Wikipedia:Sensory_nerve + @@ -106995,8 +159170,31 @@ + Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. + AAO:0000555 + BAMS:SEN + BILA:0000099 + EFO:0000805 + EHDAA2:0003094 + EMAPA:16192 + FMA:75259 + MA:0002442 + MAT:0000031 + MIAA:0000031 + NLXANAT:090816 + TAO:0000282 + VHOG:0001674 + Wikipedia:Sensory_system + XAO:0003194 + ZFA:0000282 sensory system + + + + Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. + Wikipedia:Sensory_system + @@ -107018,8 +159216,28 @@ + A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]. + BTO:0001471 + CALOHA:TS-1130 + EFO:0003078 + EHDAA2:0002212 + EHDAA:164 + EMAPA:16085 + FMA:87180 + GAID:1301 + MESH:D015017 + NCIT:C14128 + SCTID:362845002 + VHOG:0000830 + Wikipedia:Yolk_sac yolk sac + + + + A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]. + Wikipedia:Yolk_sac + @@ -107027,8 +159245,29 @@ + Anterior subdivision of a digestive tract. + AAO:0011042 + BILA:0000085 + BTO:0000507 + EHDAA2:0000557 + EHDAA:520 + EMAPA:16548 + FMA:45616 + MA:0001526 + NCIT:C34180 + SCTID:361409009 + TGMA:0001014 + VHOG:0000285 + Wikipedia:Foregut + XAO:0000232 foregut + + + + Anterior subdivision of a digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -107054,8 +159293,36 @@ + A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]. + AAO:0000967 + BTO:0001049 + CALOHA:TS-0785 + EFO:0000836 + EHDAA2:0001458 + EHDAA:2947 + EMAPA:16706 + EV:0100065 + FMA:46688 + GAID:155 + MA:0000432 + MESH:D010614 + NCIT:C12425 + SCTID:181211006 + TAO:0000056 + VHOG:0000462 + Wikipedia:Pharynx + XAO:0003227 + ZFA:0000056 + galen:Pharynx + Consider generalizing to deuterostome pharynx chordate pharynx + + + + A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]. + http://www.feedexp.org + @@ -107083,9 +159350,118 @@ - + Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). + AAO:0000145 + ANISEED:1235301 + BTO:0000959 + CALOHA:TS-0700 + EFO:0000835 + EHDAA2:0001285 + EHDAA:2937 + EMAPA:16833 + EV:0100069 + FMA:7131 + GAID:291 + MA:0000352 + MAT:0000048 + MESH:D004947 + MIAA:0000048 + NCIT:C12389 + SCTID:181245004 + TAO:0000204 + VHOG:0000450 + Wikipedia:Esophagus + XAO:0000127 + ZFA:0000204 + galen:Esophagus esophagus + + + + Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). + Wikipedia:Esophagus + http://www.rivm.nl/interspeciesinfo/inter/oesophagus/ + + + + + + + + + + + + + + + Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]. + BILA:0000086 + BTO:0000863 + EFO:0001950 + EHDAA2:0001185 + EHDAA:983 + EMAPA:16255 + FMA:45617 + MA:0001564 + NCIT:C34210 + SCTID:361410004 + TGMA:0001036 + VHOG:0000290 + Wikipedia:Midgut + XAO:0000103 + midgut + + + + + Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]. + GO:0007494 + Wikipedia:Midgut + + + + + + + + + + + + + + + + + + + + + The caudalmost subdivision of a digestive tract. + AAO:0011052 + BILA:0000087 + BTO:0000510 + EHDAA2:0000779 + EHDAA:975 + EMAPA:16715 + FMA:45618 + MA:0001527 + NCIT:C34188 + SCTID:362856002 + TGMA:0001020 + VHOG:0000459 + Wikipedia:Hindgut + XAO:0000104 + hindgut + + + + + The caudalmost subdivision of a digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -107099,8 +159475,27 @@ + Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. + AEO:0000171 + BTO:0001886 + EFO:0001652 + EHDAA2:0003171 + FMA:86589 + MAT:0000482 + NCIT:C34275 + Wikipedia:Primordium + XAO:0003043 primordium + + + + Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. + BTO:0001886 + FB:DJS + FB:FBrf0089570 + http://flybase.org/reports/FBrf0178740.html + @@ -107117,19 +159512,196 @@ + In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. + AAO:0010617 + BTO:0001057 + CALOHA:TS-2371 + DHBA:10154 + EHDAA2:0001254 + EHDAA:2869 + EHDAA:908 + EMAPA:16164 + EMAPA:16757 + FMA:293882 + MAT:0000069 + MIAA:0000069 + NCIT:C34226 + SCTID:362852000 + TAO:0001135 + VHOG:0000307 + Wikipedia:Neural_tube + XAO:0003204 + ZFA:0001135 + neuronames:1365 neural tube + + + + In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. + Wikipedia:Neural_tube + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The terminal portion of the intestinal tube, terminating with the anus. + AAO:0010401 + BTO:0001158 + CALOHA:TS-1180 + EFO:0000848 + EHDAA2:0001592 + EHDAA:5836 + EMAPA:17896 + EV:0100081 + FMA:14544 + GAID:311 + MA:0000336 + MAT:0000050 + MESH:D012007 + MIAA:0000050 + NCIT:C12390 + SCTID:181261002 + VHOG:0001751 + Wikipedia:Rectum + XAO:0000238 + galen:Rectum + rectum + + + + + The terminal portion of the intestinal tube, terminating with the anus. + ISBN:0-683-40008-8 + MP:0000492 + http://orcid.org/0000-0002-6601-2165 + - - - + Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. + AAO:0010841 + AEO:0000000 + BFO:0000004 + BILA:0000000 + BIRNLEX:6 + CARO:0000000 + EHDAA2:0002229 + FMA:62955 + HAO:0000000 + MA:0000001 + NCIT:C12219 + TAO:0100000 + TGMA:0001822 + WBbt:0000100 + XAO:0000000 + ZFA:0100000 anatomical entity + + + + Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. + FMA:62955 + http://orcid.org/0000-0001-9114-8737 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla. + BTO:0002362 + EHDAA2:0001396 + EHDAA:6905 + EMAPA:17510 + FMA:16003 + GAID:337 + MA:0000126 + MESH:D010183 + NCIT:C12272 + RETIRED_EHDAA2:0002177 + SCTID:245385001 + VHOG:0000256 + Wikipedia:Pancreatic_duct + EDITOR_NOTE in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue + ventral pancreatic duct + + + + + A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla. + Wikipedia:Pancreatic_duct + @@ -107154,8 +159726,21 @@ + A zone of skin that is part of a back [Automatically generated definition]. + EMAPA:36392 + FMA:10462 + FMA:22985 + MA:0000498 + SCTID:181492002 + EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region skin of back + + + + A zone of skin that is part of a back [Automatically generated definition]. + OBOL:automatic + @@ -107181,9 +159766,30 @@ - + A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]. + AAO:0010218 + AAO:0010416 + BTO:0004696 + EFO:0001953 + EHDAA2:0000461 + EMAPA:18611 + FMA:10635 + GAID:480 + MA:0001929 + MESH:D002342 + NCIT:C32551 + SCTID:362044002 + VHOG:0000265 + Wikipedia:External_carotid_artery + XAO:0000345 external carotid artery + + + + A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]. + MGI:anna + @@ -107214,9 +159820,21 @@ - + It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery. + FMA:10665 + MA:0002052 + NCIT:C53005 + SCTID:161746006 + Wikipedia:Superficial_part_of_transverse_cervical_artery + The transverse cervical artery splits into two branches, a superficial one and a deep one[WP] superficial cervical artery + + + + It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery. + Wikipedia:Superficial_part_of_transverse_cervical_artery + @@ -107247,9 +159865,82 @@ - + A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart. + AAO:0011083 + BTO:0002682 + EHDAA2:0000611 + EMAPA:18416 + FMA:10951 + GAID:548 + MA:0000480 + MESH:D014682 + NCIT:C12815 + SCTID:181369003 + VHOG:0001194 + Wikipedia:Inferior_vena_cava + XAO:0000388 + galen:InferiorVenaCava inferior vena cava + + + + A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart. + Wikipedia:Inferior_vena_cava + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice. + FMA:11338 + MA:0000332 + SCTID:264021000 + ileocecal junction + + + + + A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice. + http://www.medilexicon.com/medicaldictionary.php?t=46539 + @@ -107299,8 +159990,28 @@ + A potential space between the visceral and parietal layers of the pericardium. + BSA:0000091 + EHDAA2:0001434 + EMAPA:16131 + EMAPA:16132 + FMA:11350 + MA:0000053 + NCIT:C38662 + SCTID:362027001 + TAO:0002220 + VHOG:0000556 + Wikipedia:Pericardial_cavity + ZFA:0001655 + galen:PericardialSpace pericardial cavity + + + + A potential space between the visceral and parietal layers of the pericardium. + Wikipedia:Pericardium + @@ -107333,8 +160044,22 @@ + Endocardium that is part of the cardiac ventricle. + EMAPA:32747 + FMA:12148 + MA:0000079 + SCTID:192172004 + TAO:0002247 + VHOG:0000607 + ZFA:0001615 endocardium of ventricle + + + + Endocardium that is part of the cardiac ventricle. + ZFIN:curator + @@ -107359,8 +160084,18 @@ + An epicardial layer that lines a cardiac ventricle. + FMA:12150 + TAO:0005058 + ZFA:0005058 epicardium of ventricle + + + + An epicardial layer that lines a cardiac ventricle. + http://orcid.org/0000-0002-6601-2165 + @@ -107391,8 +160126,23 @@ + Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer. + EFO:0003088 + EMAPA:32748 + FMA:12151 + MA:0000082 + SCTID:192084000 + TAO:0005061 + VHOG:0000604 + ZFA:0005061 myocardium of ventricle + + + + Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer. + ZFIN:curator + @@ -107417,8 +160167,21 @@ + A zone of skin that is part of a head [Automatically generated definition]. + FMA:12166 + FMA:24756 + MA:0000582 + NCIT:C52757 + SCTID:181484006 + EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region skin of head + + + + A zone of skin that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -107443,8 +160206,21 @@ + A zone of skin that is part of a trunk [Automatically generated definition]. + FMA:12167 + FMA:23093 + MA:0000517 + NCIT:C12295 + SCTID:181489001 + EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region skin of trunk + + + + A zone of skin that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -107469,8 +160245,21 @@ + Transudate contained in the pleural cavity. + BTO:0003080 + FMA:12273 + MA:0002532 + MAT:0000500 + Wikipedia:Pleural_fluid + ncithesaurus:Pleural_Fluid pleural fluid + + + + Transudate contained in the pleural cavity. + FMA:12273 + @@ -107508,8 +160297,135 @@ + Joint fluid is a transudate of plasma that is actively secreted by synovial cells. + BTO:0001339 + CALOHA:TS-0996 + ENVO:02000039 + FMA:12277 + GAID:265 + MA:0002544 + MESH:D013582 + NCIT:C33718 + TAO:0005154 + Wikipedia:Synovial_fluid + ZFA:0005154 + galen:SynovialFluid synovial fluid + + + + Joint fluid is a transudate of plasma that is actively secreted by synovial cells. + https://www.ncbi.nlm.nih.gov/books/NBK274/ + + + + + + + + + + + + + + + The first vertebral bone in the vertebral column. + AAO:0000709 + EHDAA:10606 + EMAPA:19431 + FMA:12519 + GAID:236 + MA:0001421 + MESH:D001270 + NCIT:C32239 + SCTID:181818007 + TAO:0001167 + Wikipedia:Atlas_(anatomy) + ZFA:0001167 + vertebral bone 1 + + + + + The first vertebral bone in the vertebral column. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + The second vertebral bone in the vertebral column. + EHDAA:10608 + EMAPA:19432 + FMA:12520 + GAID:237 + MA:0001422 + MESH:D001368 + NCIT:C32240 + SCTID:181819004 + TAO:0001168 + Wikipedia:Axis_(anatomy) + ZFA:0001168 + vertebral bone 2 + + + + + The second vertebral bone in the vertebral column. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx). + EMAPA:18374 + FMA:12527 + MA:0000310 + MA:0001420 + NCIT:C32334 + SCTID:361774004 + TAO:0000326 + Wikipedia:Caudal_vertebra + XAO:0003079 + ZFA:0000326 + galen:CoccygealVertebra + Taxon notes In zebrafish, Vertebra bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae + caudal vertebra + + + + + Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx). + http://orcid.org/0000-0002-6601-2165 + @@ -107534,8 +160450,18 @@ + An anatomical wall that is part of a esophagus [Automatically generated definition]. + EMAPA:35326 + FMA:12611 + MA:0002691 wall of esophagus + + + + An anatomical wall that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -107562,8 +160488,187 @@ + A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control. + BTO:0000341 + CALOHA:TS-0198 + EFO:0000937 + EHDAA2:0003495 + EMAPA:17701 + EV:0100376 + FMA:13295 + GAID:158 + MA:0001904 + MAT:0000502 + MESH:D003964 + NCIT:C12702 + SCTID:181614006 + VHOG:0000713 + Wikipedia:Thoracid_diaphragm diaphragm + + + + A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control. + MP:0002279 + + + + + + + + + + + + + + + + Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe. + EMAPA:18306 + FMA:13361 + MA:0000360 + NCIT:C49579 + SCTID:245378000 + Wikipedia:Liver#Lobes + lobe of liver + + + + + Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe. + Wikipedia:Liver#Lobes + + + + + + + + + The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]. + EHDAA2:0001008 + EHDAA:4001 + EMAPA:18311 + FMA:13362 + MA:0000363 + NCIT:C33481 + SCTID:362182008 + TAO:0005173 + VHOG:0001424 + Wikipedia:Right_lobe_of_liver + ZFA:0005173 + right lobe of liver + + + + + The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]. + Wikipedia:Right_lobe_of_liver + + + + + + + + + The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]. + EHDAA2:0001000 + EHDAA:3995 + EMAPA:18307 + FMA:13363 + MA:0000361 + NCIT:C32965 + SCTID:362183003 + TAO:0005172 + VHOG:0001423 + Wikipedia:Left_lobe_of_liver + ZFA:0005172 + left lobe of liver + + + + + The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]. + Wikipedia:Left_lobe_of_liver + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]. + AAO:0000699 + AAO:0000734 + BTO:0000818 + EFO:0001369 + EHDA:10119 + EMAPA:35919 + FMA:13478 + GAID:106 + MA:0002416 + MESH:D013131 + NCIT:C12998 + NCIT:C33588 + NIF_Subcellular:sao1145756102 + SCTID:44300000 + TAO:0001559 + VHOG:0001142 + VSAO:0000185 + Wikipedia:Vertebral_column + XAO:0003074 + ZFA:0001559 + galen:SpinalColumn + vertebral column + + + + + Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]. + VSAO:0000185 + https://orcid.org/0000-0002-6601-2165 + https://sourceforge.net/tracker/?func=detail&aid=3530322&group_id=76834&atid=2257941 + @@ -107601,8 +160706,29 @@ + Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]. + AAO:0010245 + AEO:0000142 + BILA:0000134 + BTO:0000199 + CALOHA:TS-0440 + EHDAA2:0003142 + EMAPA:32688 + FMA:14068 + TAO:0005280 + Wikipedia:Cardiac_muscle + ZFA:0005280 + galen:CardiacMuscle + galen:CardiacMuscleTissue + ncithesaurus:Heart_Muscle cardiac muscle tissue + + + + Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]. + ZFA:0005280 + @@ -107639,8 +160765,21 @@ + Muscle tissue that consists primarily of skeletal muscle fibers. + EMAPA:32716 + FMA:14069 + MA:0002439 + NCIT:C13050 + SCTID:426215008 + Wikipedia:Skeletal_striated_muscle skeletal muscle tissue + + + + Muscle tissue that consists primarily of skeletal muscle fibers. + https://github.com/obophenotype/uberon/issues/324 + @@ -107678,8 +160817,39 @@ + Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]. + AAO:0010244 + AEO:0000141 + BTO:0001260 + CALOHA:TS-0943 + EFO:0000889 + EHDAA2:0003141 + EMAPA:32717 + EV:0100378 + FMA:14070 + GAID:167 + MA:0000166 + MAT:0000303 + MESH:D009130 + MIAA:0000303 + NCIT:C12437 + TAO:0005274 + VHOG:0001246 + WBbt:0005781 + Wikipedia:Smooth_muscle_tissue + XAO:0000175 + ZFA:0005274 + galen:SmoothMuscle + galen:SmoothMuscleTissue smooth muscle tissue + + + + Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]. + GO:0006939 + Wikipedia:Smooth_muscle_tissue + @@ -107715,8 +160885,32 @@ + Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). + AEO:0000111 + BTO:0002422 + CALOHA:TS-1183 + EHDAA2_RETIRED:0003111 + EHDAA:2331 + EHDAA:2349 + EHDAA:295 + EHDAA:6073 + EHDAA:640 + EHDAA:646 + EMAPA:32856 + FMA:14074 + MA:0000565 + NCIT:C33105 + SCTID:361918002 + Wikipedia:Mesothelium mesothelium + + + + Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). + FMA:14074 + Wikipedia:Mesothelium + @@ -107730,8 +160924,150 @@ + A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. + BTO:0001713 + CALOHA:TS-2223 + EFO:0001405 + FMA:14181 + GAID:30 + MESH:D001415 + NCIT:C13062 + SCTID:123961009 + Wikipedia:Dorsum_(anatomy) + galen:Back dorsum + + + + A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. + BSPO:0000063 + UBERONREF:0000006 + Wikipedia:Dorsum_(anatomy) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. + BTO:0002783 + EHDAA2:0001951 + EHDAA:5414 + EMAPA:18643 + FMA:14332 + MA:0002179 + NCIT:C33687 + SCTID:278031001 + VHOG:0000552 + Wikipedia:Superior_mesenteric_vein + superior mesenteric vein + + + + + In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. + Wikipedia:Superior_mesenteric_vein + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Vein that carries blood away from the liver[ZFA]. + AAO:0010216 + EMAPA:19221 + FMA:14337 + GAID:534 + MA:0003015 + MESH:D006503 + NCIT:C32736 + SCTID:278191001 + TAO:0000670 + Wikipedia:Hepatic_vein + XAO:0000387 + ZFA:0000670 + galen:HepaticVein + hepatic vein + + + + + Vein that carries blood away from the liver[ZFA]. + Wikipedia:Hepatic_vein + ZFA:0000670 + https://sourceforge.net/tracker/?func=detail&aid=3565355&group_id=76834&atid=1205376 + @@ -107763,8 +161099,346 @@ + A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries. + EMAPA:18644 + FMA:14346 + MA:0002186 + NCIT:C53058 + SCTID:278193003 + Wikipedia:Ovarian_vein ovarian vein + + + + A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries. + Wikipedia:Ovarian_vein + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct. + EHDAA2:0000333 + EHDAA:3045 + EMAPA:16841 + FMA:14539 + GAID:290 + MA:0000355 + MESH:D003549 + NCIT:C32421 + SCTID:245398005 + TAO:0005166 + VHOG:0000213 + Wikipedia:Cystic_duct + ZFA:0005166 + galen:CysticDuct + cystic duct + + + + + The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct. + ISBN:0-683-40008-8 + MP:0009493 + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal. + AAO:0010400 + BTO:0000269 + CALOHA:TS-0158 + EFO:0000361 + EMAPA:18939 + EV:0100079 + FMA:14543 + GAID:309 + MA:0000335 + MAP:0000001 + MAT:0000526 + MESH:D003106 + NCIT:C12382 + SCTID:302508007 + TAO:0000706 + VHOG:0000648 + Wikipedia:Colon_(anatomy) + XAO:0000243 + ZFA:0000706 + galen:Colon + colon + + + + + A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal. + Wikipedia:Colon_(anatomy) + ZFIN:curator + http://orcid.org/0000-0002-2825-0621 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity. + BTO:0000645 + CALOHA:TS-2044 + EFO:0000846 + EMAPA:36391 + FMA:14548 + MAT:0000314 + MESH:D012809 + MIAA:0000314 + NCIT:C12384 + NCIT:C33550 + SCTID:362166007 + Wikipedia:Sigmoid_colon + galen:SigmoidColon + sigmoid colon + + + + + The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity. + Wikipedia:Sigmoid_colon + + + + + + + + + The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]. + BTO:0000505 + EMAPA:35810 + FMA:14560 + MA:0002559 + NCIT:C12258 + SCTID:362140009 + Wikipedia:Body_of_stomach + galen:GastricCorpus + body of stomach + + + + + The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]. + GO:0014845 + Wikipedia:Body_of_stomach + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells. + BTO:0001732 + EFO:0002555 + EMAPA:17891 + FMA:14579 + GAID:332 + MA:0001624 + MESH:D011706 + NCIT:C12259 + SCTID:362142001 + Wikipedia:Pyloric_antrum + galen:PyloricAntrum + pyloric antrum + + + + + The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells. + ISBN:0-683-40008-8 + MP:0010790 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum. + BTO:0001146 + EHDAA2:0001580 + EHDAA:4860 + EMAPA:17631 + FMA:14581 + GAID:333 + MA:0002560 + MESH:D011708 + NCIT:C12260 + SCTID:362143006 + VHOG:0000420 + Wikipedia:Pylorus + galen:Pylorus + pylorus + + + + + The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum. + MGI:csmith + MP:0010785 + @@ -107795,8 +161469,480 @@ + The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between. + EMAPA:35826 + FMA:14582 + MA:0002692 + SCTID:279995000 + galen:WallOfStomach wall of stomach + + + + The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between. + MGI:csmith + MP:0010783 + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical wall that is part of a small intestine [Automatically generated definition]. + EMAPA:35785 + FMA:14615 + MA:0002696 + NCIT:C33573 + wall of small intestine + + + + + An anatomical wall that is part of a small intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical wall that is part of a large intestine [Automatically generated definition]. + EMAPA:35470 + FMA:14619 + MA:0002695 + wall of large intestine + + + + + An anatomical wall that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]. + FMA:14643 + MA:0001555 + SCTID:245456008 + Wikipedia:Mesentery#Mesentery_.28proper.29 + mesentery of small intestine + + + + + The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]. + Wikipedia:Mesentery#Mesentery_.28proper.29 + + + + + + + + + + + + + + + + + + + + + + The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. + FMA:14653 + MA:0002498 + NCIT:C33341 + portal lobule + + + + + The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. + MP:0008992 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids. + EMAPA:35497 + FMA:14654 + MA:0002496 + NCIT:C32992 + SCTID:272214009 + hepatic acinus + + + + + The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids. + http://orcid.org/0000-0002-6601-2165 + http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_acinus.html + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder. + AAO:0011020 + EMAPA:35172 + FMA:14665 + SCTID:181267003 + Wikipedia:Biliary_tract + XAO:0000455 + The path in many species is as follows: Bile canaliculi -> Canals of Hering (intralobar bile duct) -> interlobular bile ducts -> intrahepatic bile ducts -> left and right hepatic ducts merge to form -> common hepatic duct *exits liver* and joins -> cystic duct (from gall bladder) forming -> common bile duct -> joins with pancreatic duct -> forming ampulla of Vater -> enters duodenum [WP] + biliary tree + + + + + A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder. + DOI:10.1002/ar.20664 + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct. + EHDAA2:0000303 + EHDAA:3981 + EMAPA:17201 + FMA:14667 + GAID:282 + MA:0001631 + MESH:D003135 + NCIT:C12698 + SCTID:362199009 + TAO:0005165 + VHOG:0000214 + Wikipedia:Common_bile_duct + ZFA:0005165 + galen:CommonBileDuct + common bile duct + + + + + The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct. + MGI:csmith + MP:0009495 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]. + EMAPA:19101 + FMA:14668 + GAID:286 + MA:0002660 + MESH:D006500 + NCIT:C32356 + SCTID:245403006 + VHOG:0000220 + Wikipedia:Common_hepatic_duct + common hepatic duct + + + + + Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]. + Wikipedia:Common_hepatic_duct + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct. + EHDAA2:0001727 + EHDAA:3992 + EMAPA:32797 + FMA:14669 + MA:0001639 + NCIT:C33476 + SCTID:245401008 + VHOG:0000217 + right hepatic duct + + + + + The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct. + http://www.medterms.com/script/main/art.asp?articlekey=26034 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct. + EHDAA2:0000941 + EHDAA:3990 + EMAPA:32795 + FMA:14670 + MA:0001638 + NCIT:C32960 + SCTID:245400009 + VHOG:0000218 + left hepatic duct + + + + + The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct. + http://www.medterms.com/script/main/art.asp?articlekey=26035 + @@ -107821,8 +161967,23 @@ + The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space. + EMAPA:16592 + FMA:14703 + SCTID:362702003 + TAO:0005132 + VHOG:0001528 + Wikipedia:Visceral_peritoneum + ZFA:0005132 visceral peritoneum + + + + The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space. + Wikipedia:Peritoneum#Types + http://orcid.org/0000-0002-6601-2165 + @@ -107879,8 +162040,28 @@ + Anatomical cavity bounded by visceral and parietal peritoneum. + BTO:0001782 + EHDAA2:0001446 + EMAPA:16138 + FMA:14704 + GAID:24 + MA:0000054 + MESH:D010529 + NCIT:C12769 + SCTID:181616008 + VHOG:0000852 + Wikipedia:Peritoneal_cavity peritoneal cavity + + + + Anatomical cavity bounded by visceral and parietal peritoneum. + Wikipedia:Peritoneal_cavity + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/86 + @@ -107911,9 +162092,116 @@ - + An artery that supplies an ovary. + EMAPA:18620 + FMA:14761 + MA:0002012 + NCIT:C33242 + SCTID:244280002 + Wikipedia:Ovarian_artery ovarian artery + + + + An artery that supplies an ovary. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An artery that supplies the liver. + BTO:0004307 + EMAPA:17859 + FMA:14769 + GAID:496 + MA:0001963 + MESH:D006499 + NCIT:C32729 + SCTID:76015000 + TAO:0005161 + ZFA:0005161 + galen:HepaticArtery + hepatic artery + + + + + An artery that supplies the liver. + Wikipedia:Hepatic_artery_proper + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An artery that supplies the spleen. + EMAPA:19216 + FMA:14773 + GAID:510 + MA:0001991 + MA:0003177 + MESH:D013157 + NCIT:C33597 + SCTID:244266009 + Wikipedia:Splenic_artery + galen:SplenicArtery + splenic artery + + + + + An artery that supplies the spleen. + http://orcid.org/0000-0002-6601-2165 + @@ -107950,8 +162238,26 @@ + The mucosal layer that lines the stomach. + BTO:0001308 + CALOHA:TS-0404 + EMAPA:35817 + FMA:14907 + GAID:321 + MA:0002683 + MESH:D005753 + NCIT:C32656 + SCTID:362131005 + Wikipedia:Gastric_mucosa + galen:GastricMucosa mucosa of stomach + + + + The mucosal layer that lines the stomach. + http://orcid.org/0000-0002-6601-2165 + @@ -107982,8 +162288,22 @@ + The fibrous connective tissue layer beneath the stomach mucosa. + BTO:0002110 + EMAPA:35825 + FMA:14908 + MA:0002685 + NCIT:C32663 + SCTID:52459002 submucosa of stomach + + + + The fibrous connective tissue layer beneath the stomach mucosa. + MGI:csmith + MP:0010794 + @@ -108014,8 +162334,890 @@ + The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum. + EMAPA:35822 + FMA:14914 + MA:0001626 + NCIT:C32662 + SCTID:1353004 serosa of stomach + + + + The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum. + MGI:csmith + MP:0010793 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]. + AAO:0011093 + EMAPA:19251 + FMA:14916 + MA:0002952 + NCIT:C33433 + SCTID:268073008 + VHOG:0001466 + XAO:0000457 + pyloric sphincter + + + + + A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a small intestine [Automatically generated definition]. + BTO:0001259 + CALOHA:TS-0941 + EMAPA:35780 + FMA:14933 + MA:0002686 + NCIT:C33568 + SCTID:362144000 + mucosa of small intestine + + + + + A mucosa that is part of a small intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Submucosal tissue in the small intestines. + BTO:0002112 + FMA:14934 + MA:0001562 + NCIT:C33572 + SCTID:691000 + Wikipedia:Small_intestinal_submucosa + submucosa of small intestine + + + + + Submucosal tissue in the small intestines. + Wikipedia:Small_intestinal_submucosa + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a small intestine [Automatically generated definition]. + FMA:14938 + MA:0001558 + SCTID:8266009 + serosa of small intestine + + + + + A serous membrane that is part of a small intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a large intestine [Automatically generated definition]. + CALOHA:TS-2106 + EMAPA:35467 + FMA:14969 + MA:0002688 + NCIT:C32926 + mucosa of large intestine + + + + + A mucosa that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a large intestine [Automatically generated definition]. + BTO:0002111 + FMA:14970 + MA:0002690 + NCIT:C32930 + submucosa of large intestine + + + + + A submucosa that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a large intestine [Automatically generated definition]. + FMA:14975 + MA:0001546 + NCIT:C32929 + serosa of large intestine + + + + + A serous membrane that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]. + BTO:0002376 + EMAPA:36522 + FMA:15060 + GAID:314 + MA:0001551 + MESH:D002011 + NCIT:C13010 + SCTID:41298001 + Wikipedia:Brunner's_glands + duodenal gland + + + + + A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]. + Wikipedia:Brunner's_glands + + + + + + + + + + + + + + + + + + + + + + + + + + + The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold. + BTO:0003121 + EMAPA:35784 + FMA:15072 + MA:0001563 + NCIT:C33874 + SCTID:23230007 + TAO:0005125 + Wikipedia:Intestinal_villus + ZFA:0005125 + intestinal villus + + + + + The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold. + MGI:csmith + MGI:rbabiuk + MP:0008108 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. + BTO:0002782 + EHDAA2:0000819 + EHDAA:8712 + EMAPA:18642 + FMA:15391 + MA:0002178 + NCIT:C32782 + SCTID:281055007 + VHOG:0001118 + Wikipedia:Inferior_mesenteric_vein + inferior mesenteric vein + + + + + A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. + Wikipedia:Inferior_mesenteric_vein + + + + + + + + + + + + + + + + + + + + + + + + + + Lamina propria that is part_of the small intestine. + EMAPA:35779 + FMA:15651 + MA:0001554 + NCIT:C49297 + SCTID:63588008 + lamina propria of small intestine + + + + + Lamina propria that is part_of the small intestine. + GOC:Obol + + + + + + + + + + + + + + + + + + + + + + + + + + Mucosal layer that lines the intestine. + BTO:0000642 + EMAPA:35440 + FMA:15695 + GAID:296 + MA:0001537 + MESH:D007413 + NCIT:C49241 + SCTID:362080002 + intestinal mucosa + + + + + Mucosal layer that lines the intestine. + UBERON:cjm + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a wall of intestine [Automatically generated definition]. + FMA:15701 + MA:0001538 + serosa of intestine + + + + + A serous membrane that is part of a wall of intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts. + BTO:0001680 + CALOHA:TS-2005 + EV:0100082 + FMA:15711 + GAID:312 + MA:0000331 + NCIT:C43362 + SCTID:181262009 + TADS:0000066 + TGMA:0001279 + WBbt:0005364 + Wikipedia:Anus + galen:Anus + anus + + + + + Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts. + Wikipedia:Anus + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad. + FMA:15767 + MA:0002668 + NCIT:C32827 + SCTID:83488001 + Wikipedia:Interlobular_bile_ducts + interlobular bile duct + + + + + The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad. + MP:0009500 + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical wall that is part of a intestine [Automatically generated definition]. + BTO:0000647 + EMAPA:35444 + FMA:15949 + MA:0001525 + MA:0002693 + NCIT:C49478 + wall of intestine + + + + + An anatomical wall that is part of a intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct. + EMAPA:35651 + FMA:16011 + MA:0002417 + NCIT:C49268 + SCTID:247604006 + pancreatic acinus + + + + + The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct. + MP:0009145 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]. + AAO:0010112 + BTO:0000988 + CALOHA:TS-0736 + EFO:0000855 + EHDAA2:0001367 + EHDAA:6893 + EMAPA:17503 + EV:0100092 + FMA:7198 + GAID:334 + MA:0000120 + MAT:0000075 + MESH:D010179 + MIAA:0000075 + NCIT:C12393 + SCTID:181277001 + TAO:0000140 + VHOG:0000050 + Wikipedia:Pancreas + XAO:0000136 + ZFA:0000140 + galen:Pancreas + pancreas + + + + + An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]. + GO:0031016 + + + + + + + + + + + + + + + + + + + + + + + + + + + A trabecula that is part of a spleen. + EMAPA:35808 + FMA:16027 + MA:0000758 + NCIT:C33607 + SCTID:61987002 + Wikipedia:Trabeculae_of_spleen + trabecula of spleen + + + + + A trabecula that is part of a spleen. + OBOL:automatic + @@ -108042,8 +163244,21 @@ + Transudate contained in the peritoneal cavity. + BTO:0001031 + EMAPA:35683 + FMA:16515 + MA:0002531 + Wikipedia:Peritoneal_fluid + ncithesaurus:Peritoneal_Fluid peritoneal fluid + + + + Transudate contained in the peritoneal cavity. + FMA:16515 + @@ -108077,8 +163292,386 @@ + The epithelial layer of the stomach . + BTO:0000500 + CALOHA:TS-2068 + EHDAA2:0001918 + EMAPA:17023 + FMA:17091 + MA:0001610 + SCTID:64977002 + VHOG:0001433 epithelium of stomach + + + + The epithelial layer of the stomach . + MP:0000471 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Epithelial layer that lines the intestine. + BTO:0000781 + EMAPA:32873 + FMA:17229 + MA:0001536 + NCIT:C49240 + SCTID:266135004 + TAO:0005124 + Wikipedia:Intestinal_epithelium + ZFA:0005124 + intestinal epithelium + + + + + Epithelial layer that lines the intestine. + UBERON:cjm + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a large intestine [Automatically generated definition]. + CALOHA:TS-2105 + EMAPA:35466 + FMA:17301 + MA:0001545 + epithelium of large intestine + + + + + An epithelium that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. + FMA:17523 + MA:0002499 + NCIT:C33342 + SCTID:362192000 + Wikipedia:Portal_triad + portal triad + + + + + A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. + ISBN:0-683-40008-8 + MGI:csmith + MP:0008993 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The functional units of the liver including the lobules. + AAO:0010405 + EHDAA2:0001004 + EHDAA:2201 + EMAPA:17203 + FMA:17540 + MA:0000366 + NCIT:C32735 + SCTID:363535004 + UMLS:C0736268 + VHOG:0000539 + XAO:0000454 + liver parenchyma + + + + + The functional units of the liver including the lobules. + MP:0008986 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers. + EHDAA2:0000999 + EMAPA:17365 + FMA:17543 + MA:0000367 + NCIT:C32733 + SCTID:67435004 + TAO:0005091 + VHOG:0000708 + Wikipedia:Hepatic_sinusoid + ZFA:0005091 + hepatic sinusoid + + + + + Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers. + Wikipedia:Hepatic_sinusoid + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule. + FMA:17545 + MA:0002669 + NCIT:C32255 + SCTID:227002 + SCTID:269922006 + Wikipedia:Canals_of_Hering + intralobular bile duct + + + + + The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule. + MGI:csmith + MP:0009499 + + + + + + + + + + + + + + + + + + + + + The anus and surrounding regions. Encompasses both internal and external regions, where present. + EFO:0000847 + EHDAA2:0000122 + EHDAA:2931 + EMAPA:16831 + MA:0000329 + MAT:0000042 + MIAA:0000042 + NCIT:C32069 + SCTID:362680001 + VHOG:0000395 + WBbt:0006919 + anal region + + + + + The anus and surrounding regions. Encompasses both internal and external regions, where present. + https://orcid.org/0000-0002-6601-2165 + @@ -108109,8 +163702,24 @@ + The outer layer of peritoneum that is attached to the abdominal and pelvic walls. + AAO:0010816 + EMAPA:16591 + FMA:21451 + SCTID:362700006 + TAO:0005131 + VHOG:0001527 + Wikipedia:Parietal_peritoneum + ZFA:0005131 parietal peritoneum + + + + The outer layer of peritoneum that is attached to the abdominal and pelvic walls. + Wikipedia:Peritoneum#Types + http://orcid.org/0000-0002-6601-2165 + @@ -108135,8 +163744,21 @@ + A zone of skin that is part of an abdomen [Automatically generated definition]. + EFO:0000214 + FMA:22988 + FMA:23000 + MA:0000523 + NCIT:C52758 + SCTID:361707007 skin of abdomen + + + + A zone of skin that is part of an abdomen [Automatically generated definition]. + OBOL:automatic + @@ -108161,8 +163783,20 @@ + A zone of skin that is part of a neck [Automatically generated definition]. + FMA:23021 + FMA:23022 + MA:0000590 + NCIT:C52756 + SCTID:361705004 skin of neck + + + + A zone of skin that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -108187,8 +163821,19 @@ + A zone of skin that is part of a thorax [Automatically generated definition]. + FMA:23028 + FMA:23029 + MA:0000564 + SCTID:281723000 skin of thorax + + + + A zone of skin that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -108227,8 +163872,21 @@ + An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions. + FMA:23217 + SCTID:229759004 + VSAO:0000305 + galen:ShoulderGirdle pectoral girdle region + + + + An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions. + FMA:23217 + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + @@ -108277,14 +163935,39 @@ + + + Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. + AAO:0000566 + BTO:0001486 + CALOHA:TS-1320 + EFO:0000806 + EHDAA2:0003168 + EMAPA:35773 + FMA:23881 + MA:0000018 + NCIT:C12788 + TAO:0000434 + VHOG:0001254 + VSAO:0000027 + XAO:0003060 + ZFA:0000434 skeletal system + + + + Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. + GO_REF:0000034 + VSAO:0000027 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -108298,6 +163981,9 @@ + FMA:24218 + SCTID:123852005 + XAO:0000040 subdivision of head @@ -108319,8 +164005,27 @@ + A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc). + BTO:0003369 + CALOHA:TS-2216 + EMAPA:32763 + FMA:24728 + GAID:64 + HAO:0000316 + MA:0002473 + MESH:D005145 + NCIT:C13071 + SCTID:302549007 + Wikipedia:Face + galen:Face face + + + + A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc). + http://orcid.org/0000-0002-6601-2165 + @@ -108345,8 +164050,19 @@ + A zone of skin that is part of a lip [Automatically generated definition]. + FMA:24764 + MA:0001579 + NCIT:C12291 + SCTID:244092005 skin of lip + + + + A zone of skin that is part of a lip [Automatically generated definition]. + OBOL:automatic + @@ -108379,8 +164095,43 @@ + Skeletal element that is composed of bone tissue. + AAO:0000047 + AEO:0000082 + BTO:0000140 + CALOHA:TS-0088 + EFO:0000298 + EHDAA2:0003082 + EMAPA:32782 + ENVO:00002039 + EV:0100140 + FMA:30317 + FMA:5018 + GAID:92 + MA:0001459 + MAT:0000299 + MIAA:0000299 + NCIT:C12366 + SCTID:90780006 + TAO:0001514 + VHOG:0001190 + VSAO:0000057 + Wikipedia:Bone + XAO:0000169 + ZFA:0001514 + galen:Bone bone element + + + + Skeletal element that is composed of bone tissue. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000057 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/277 + @@ -108415,8 +164166,24 @@ + An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. + FMA:34836 + GAID:263 + MA:0001519 + MESH:D017746 + NCIT:C32259 + NCIT:C84388 + SCTID:182238002 + Wikipedia:Articular_capsule + galen:JointCapsule articular capsule + + + + An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. + Wikipedia:Articular_capsule + @@ -108454,9 +164221,24 @@ - + The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]. + EHDAA2:0000147 + EHDAA:9828 + EMAPA:17014 + FMA:3736 + MA:0002570 + NCIT:C32150 + SCTID:181299009 + Wikipedia:Ascending_aorta ascending aorta + + + + The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]. + GO:0035905 + Wikipedia:Ascending_aorta + @@ -108500,9 +164282,26 @@ - + The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery. + BTO:0000157 + EFO:0002526 + EHDAA2:0000132 + EMAPA:17613 + FMA:3768 + GAID:471 + MA:0000475 + SCTID:181300001 + VHOG:0001196 + Wikipedia:Arch_of_aorta arch of aorta + + + + The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery. + ISBN:0-683-40008-8 + MP:0004113 + @@ -108534,9 +164333,22 @@ - + The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]. + EMAPA:18606 + FMA:3784 + MA:0002571 + NCIT:C32455 + SCTID:261399002 + Wikipedia:Descending_aorta descending aorta + + + + The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]. + GO:0035906 + Wikipedia:Descending_aorta + @@ -108567,8 +164379,27 @@ + The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + BTO:0000157 + EFO:0002525 + EMAPA:18603 + FMA:3786 + GAID:471 + MA:0002569 + MESH:D001013 + NCIT:C33766 + SCTID:302510009 + Wikipedia:Thoracic_aorta + galen:ThoracicAorta thoracic aorta + + + + The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + MP:0010468 + http://www.medterms.com + @@ -108600,9 +164431,27 @@ - + Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]. + BTO:0002976 + EFO:0002524 + EMAPA:17856 + FMA:3789 + GAID:470 + MA:0000474 + MESH:D001012 + NCIT:C32038 + SCTID:244231007 + Wikipedia:Abdominal_aorta + galen:AbdominalAorta abdominal aorta + + + + Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]. + BTO:0002976 + Wikipedia:Abdominal_aorta + @@ -108628,9 +164477,27 @@ - + The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery. + EFO:0002550 + EHDAA2:0000835 + EMAPA:17615 + FMA:3932 + GAID:476 + MA:0001922 + MESH:D016122 + NCIT:C32814 + SCTID:244244002 + Wikipedia:Brachiocephalic_artery + galen:BrachioCephalicArtery brachiocephalic artery + + + + The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery. + MGI:csmith + MP:0010663 + @@ -108656,9 +164523,27 @@ - + A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]. + CALOHA:TS-0116 + EHDAA2:0000217 + EHDAA:7331 + EMAPA:17855 + FMA:3939 + GAID:479 + MA:0001926 + MESH:D017536 + NCIT:C32352 + SCTID:362041005 + VHOG:0000272 + Wikipedia:Common_carotid_artery common carotid artery plus branches + + + + A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]. + Wikipedia:Common_carotid_artery + @@ -108696,9 +164581,30 @@ - + One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta. + AAO:0010232 + EHDAA2:0001933 + EHDAA:4357 + EMAPA:17617 + FMA:3951 + GAID:511 + MA:0002045 + MESH:D013348 + NCIT:C33643 + SCTID:265790007 + TAO:0005086 + Wikipedia:Subclavian_artery + XAO:0000365 + ZFA:0005086 subclavian artery + + + + One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta. + ISBN:0073040584 + https://orcid.org/0000-0002-6601-2165 + @@ -108730,9 +164636,21 @@ - + The subclavian artery that supplies the right pectoral appendage. + EHDAA2:0004514 + FMA:3953 + MA:0002047 + NCIT:C33490 + SCTID:244246000 + Wikipedia:Subclavian_artery right subclavian artery + + + + The subclavian artery that supplies the right pectoral appendage. + http://orcid.org/0000-0002-6601-2165 + @@ -108764,9 +164682,32 @@ - + A tube extending from the mouth to the anus. + AAO:0010023 + BILA:0000083 + BTO:0000511 + BTO:0000545 + EHDAA2:0000726 + EHDAA:518 + EMAPA:16247 + FMA:45615 + MA:0000917 + NCIT:C34082 + TAO:0000112 + TGMA:0001819 + VHOG:0000309 + WBbt:0005743 + ZFA:0000112 + galen:AlimentaryTract digestive tract + + + + A tube extending from the mouth to the anus. + Wikipedia:Talk:Human_gastrointestinal_tract + https://github.com/geneontology/go-ontology/issues/7549 + @@ -108780,9 +164721,23 @@ - + The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]. + EHDAA2:0001036 + EMAPA:16738 + FMA:45662 + MA:0000435 + SCTID:281488008 + VHOG:0000382 + Wikipedia:Lower_respiratory_tract lower respiratory tract + + + + The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]. + Wikipedia:Lower_respiratory_tract + http://orcid.org/0000-0002-6601-2165 + @@ -108814,9 +164769,20 @@ - + The subclavian artery that supplies the left pectoral appendage. + FMA:4694 + MA:0002046 + NCIT:C32972 + SCTID:244245001 + Wikipedia:Subclavian_artery left subclavian artery + + + + The subclavian artery that supplies the left pectoral appendage. + http://orcid.org/0000-0002-6601-2165 + @@ -108847,9 +164813,29 @@ - + A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart. + BTO:0002683 + EHDAA2:0001962 + EHDAA:8726 + EMAPA:18417 + FMA:4720 + GAID:549 + MA:0000481 + MESH:D014683 + NCIT:C12816 + SCTID:181368006 + VHOG:0001195 + Wikipedia:Superior_vena_cava + galen:SuperiorVenaCava anterior vena cava + + + + A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart. + Wikipedia:Superior_vena_cava + http://orcid.org/0000-0002-6601-2165 + @@ -108875,9 +164861,27 @@ - + One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]. + AAO:0010236 + EHDAA2:0000877 + EHDAA:5407 + EMAPA:17620 + FMA:4724 + MA:0002157 + NCIT:C32849 + RETIRED_EHDAA2:0000878 + SCTID:181372005 + Wikipedia:Internal_jugular_vein + XAO:0000382 + galen:InternalJugularVein internal jugular vein + + + + One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]. + Wikipedia:Internal_jugular_vein + @@ -108902,9 +164906,21 @@ - + The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]. + EMAPA:36284 + FMA:4749 + MA:0002088 + NCIT:C53031 + SCTID:198293000 + Wikipedia:Bronchial_veins bronchial vein + + + + The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted]. + Wikipedia:Bronchial_veins + @@ -108920,9 +164936,22 @@ - + The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. + BTO:0000654 + EMAPA:35240 + FMA:49151 + MA:0001269 + NCIT:C32315 + SCTID:280862009 + Wikipedia:Ciliary_muscle ciliary muscle + + + + The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. + Wikipedia:Ciliary_muscle + @@ -108947,11 +164976,122 @@ + FMA:49154 + MA:0001287 + SCTID:280888007 + Wikipedia:Iris_muscle muscle of iris + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A sphincter muscle that is part of the iris. + BTO:0000656 + EMAPA:35788 + FMA:49157 + MA:0001289 + NCIT:C33586 + SCTID:280889004 + Wikipedia:Iris_sphincter_muscle + sphincter pupillae + + + + + A sphincter muscle that is part of the iris. + Wikipedia:Iris_sphincter_muscle + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]. + BTO:0001371 + EMAPA:35286 + FMA:49158 + MA:0001288 + NCIT:C32463 + SCTID:280890008 + Wikipedia:Iris_dilator_muscle + dilatator pupillae + + + + + A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]. + Wikipedia:Iris_dilator_muscle + + + + @@ -108977,9 +165117,21 @@ - + A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]. + EMAPA:19213 + FMA:49549 + MA:0001950 + NCIT:C32578 + SCTID:181328007 + Wikipedia:Facial_artery facial artery + + + + A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]. + Wikipedia:Facial_artery + @@ -109011,8 +165163,25 @@ + Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. + EV:0100146 + FMA:5022 + GAID:131 + MA:0000015 + SCTID:71616004 + TAO:0005145 + VHOG:0001245 + XAO:0000172 + ZFA:0005145 + galen:Muscle muscle organ + + + + Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. + GO:0007517 + @@ -109026,8 +165195,37 @@ + An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]. + AAO:0010211 + AEO:0000208 + BTO:0000573 + CALOHA:TS-0054 + EFO:0000814 + EHDAA2:0003253 + EMAPA:35147 + EV:0100026 + FMA:50720 + GAID:468 + MA:0000064 + MAT:0000034 + MESH:D001158 + MIAA:0000034 + NCIT:C12372 + SCTID:362877004 + TAO:0000005 + VHOG:0001251 + Wikipedia:Artery + XAO:0000114 + ZFA:0000005 + galen:Artery artery + + + + An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]. + AEO:JB + @@ -109058,8 +165256,130 @@ + Any of the tubular branching vessels that carry blood from the capillaries toward the heart. + AAO:0010212 + AEO:0000209 + BTO:0000234 + CALOHA:TS-1108 + EFO:0000816 + EHDAA2:0003254 + EMAPA:35906 + EV:0100031 + FMA:50723 + GAID:492 + MA:0000067 + MAT:0000037 + MESH:D014680 + MIAA:0000037 + NCIT:C12814 + SCTID:181367001 + TAO:0000082 + VHOG:0001743 + Wikipedia:Vein + XAO:0000115 + ZFA:0000082 + galen:Vein vein + + + + Any of the tubular branching vessels that carry blood from the capillaries toward the heart. + Wikipedia:Vein + + + + + + + + + + + + + + + + + + + + + + + + + + + A portal vein that transports nutrients from the digestive tract to the liver[Kardong]. + AAO:0010214 + FMA:50735 + MA:0002132 + TAO:0005090 + VHOG:0000642 + Wikipedia:Hepatic_portal_vein + ZFA:0005090 + hepatic portal vein + + + + + A portal vein that transports nutrients from the digestive tract to the liver[Kardong]. + ISBN:0073040584 + Wikipedia:Hepatic_portal_vein + http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The first major branch of the abdominal aorta. + EHDAA2:0004519 + EMAPA:35202 + FMA:50737 + GAID:483 + MA:0001931 + MESH:D002445 + NCIT:C52846 + SCTID:181340007 + Wikipedia:Celiac_artery + dorsal aorta in Kardong + celiac artery + + + + + The first major branch of the abdominal aorta. + Wikipedia:Celiac_artery + @@ -109120,9 +165440,40 @@ - + Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw). + AAO:0010470 + BAMS:5n + BAMS:Vn + BAMS:nV + BIRNLEX:869 + BM:VN + BTO:0001072 + EFO:0001402 + EHDAA2:0002084 + EHDAA:3738 + EMAPA:17576 + FMA:50866 + GAID:726 + MA:0001100 + MBA:901 + MESH:D014276 + MFMO:0000093 + NCIT:C12806 + SCTID:362459002 + TAO:0000697 + VHOG:0000704 + Wikipedia:Trigeminal_nerve + XAO:0003092 + ZFA:0000697 trigeminal nerve + + + + Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw). + ISBN:0471209627 + Wikipedia:Trigeminal_nerve + @@ -109153,9 +165504,21 @@ - + The pulmonary artery that supplies the right lung. + FMA:50872 + MA:0002500 + NCIT:C33489 + SCTID:244235003 + Wikipedia:Right_pulmonary_artery + galen:RightPulmonaryArtery right pulmonary artery + + + + The pulmonary artery that supplies the right lung. + UBERON:cjm + @@ -109186,9 +165549,21 @@ - + The pulmonary artery that supplies the left lung. + FMA:50873 + MA:0002032 + NCIT:C32971 + SCTID:244234004 + Wikipedia:Left_pulmonary_artery + galen:LeftPulmonaryArtery left pulmonary artery + + + + The pulmonary artery that supplies the left lung. + UBERON:cjm + @@ -109209,9 +165584,22 @@ - + The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]. + AAO:0010513 + EMAPA:19220 + FMA:50874 + MA:0002115 + NCIT:C32579 + SCTID:181374006 + Wikipedia:Facial_vein facial vein + + + + The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]. + Wikipedia:Facial_vein + @@ -109244,8 +165632,39 @@ + The cranial ganglion that is associated with and extends fibers into the trigeminal nerve. + AAO:0011107 + BAMS:5Gn + BAMS:GV + BTO:0001231 + EFO:0000903 + EHDAA2:0002085 + EHDAA:2113 + EMAPA:16797 + FMA:52618 + GAID:725 + MA:0001080 + MAT:0000511 + MESH:D012668 + NCIT:C62642 + SCTID:244449009 + TAO:0000295 + VHOG:0000694 + Wikipedia:Trigeminal_ganglion + XAO:0000427 + XAO:0000428 + ZFA:0000295 + neuronames:1402 trigeminal ganglion + + + + The cranial ganglion that is associated with and extends fibers into the trigeminal nerve. + http://orcid.org/0000-0002-6601-2165 + http://www.ncbi.nlm.nih.gov/books/NBK53171 + https://github.com/obophenotype/uberon/issues/693 + @@ -109290,9 +165709,194 @@ - + The bone at the lower, posterior part of the skull. + EMAPA:25112 + FMA:52735 + GAID:227 + MA:0001468 + MESH:D009777 + NCIT:C12757 + SCTID:181796003 + Wikipedia:Occipital_bone occipital bone + + + + The bone at the lower, posterior part of the skull. + ISBN:0-683-40008-8 + MP:0005269 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended. + CALOHA:TS-2343 + EMAPA:18340 + FMA:52736 + GAID:230 + MA:0001472 + MESH:D013100 + NCIT:C12790 + SCTID:272676008 + Wikipedia:Sphenoid_bone + sphenoid bone + + + + + An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended. + Wikipedia:Sphenoid_bone + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]. + BTO:0004140 + EMAPA:19018 + FMA:52740 + GAID:212 + MA:0001483 + MESH:D005004 + NCIT:C12711 + SCTID:272674006 + VHOG:0001317 + Wikipedia:Ethmoid_bone + ethmoid bone + + + + + A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]. + Wikipedia:Ethmoid_bone + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball. + BTO:0004687 + FMA:53074 + GAID:223 + MA:0002482 + MESH:D009915 + NCIT:C12347 + TAO:0001410 + Wikipedia:Orbit_(anatomy) + XAO:0003171 + ZFA:0001410 + galen:Orbit + orbit of skull + + + + + Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball. + TAO:0001410 + Wikipedia:Orbit_(anatomy) + http://orcid.org/0000-0002-6601-2165 + @@ -109324,9 +165928,25 @@ - + Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof. + FMA:53672 + MA:0000317 + SCTID:361731002 + TAO:0001580 + Wikipedia:Neuroranium + XAO:0003170 + ZFA:0001580 neurocranium + + + + Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof. + PMID:11523816 + TAO:MAH + Wikipedia:Neuroranium + ZFA:0001580 + @@ -109382,8 +166002,88 @@ + Subdivision of skeleton which includes upper and lower jaw skeletons. + AAO:0000988 + BTO:0001749 + EMAPA:35455 + FMA:54396 + GAID:214 + MA:0001905 + MESH:D007568 + NCIT:C48821 + SCTID:181811001 + TAO:0001227 + Wikipedia:Jaw + ZFA:0001227 + galen:Jaw jaw skeleton + + + + Subdivision of skeleton which includes upper and lower jaw skeletons. + Wikipedia:Jaw + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. + AAO:0000620 + EHDAA2:0002118 + EHDAA2:0004607 + EHDAA:8025 + EMAPA:17924 + FMA:59399 + SCTID:362636001 + VHOG:0000454 + Wikipedia:Upper_jaw + ncithesaurus:Upper_Jaw + See notes for jaw w.r.t skeletal element vs subdivision of head. + upper jaw region + + + + + Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. + Wikipedia:Upper_jaw + http://orcid.org/0000-0002-6601-2165 + @@ -109421,8 +166121,27 @@ + Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. + AAO:0000272 + EFO:0003660 + EHDAA2:0001018 + EHDAA:7995 + EMAPA:17906 + FMA:59398 + MESH:D008334 + SCTID:362637005 + VHOG:0000453 + Wikipedia:Lower_jaw + ncithesaurus:Lower_Jaw + See notes for jaw w.r.t skeletal element vs subdivision of head lower jaw region + + + + Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. + Wikipedia:Lower_jaw + @@ -109453,9 +166172,33 @@ - + The groups of nerve cell bodies associated with the twelve cranial nerves. + BIRNLEX:2597 + BTO:0000106 + EFO:0000902 + EMAPA:16659 + FMA:54502 + MA:0000213 + MA:0000214 + MAT:0000200 + MIAA:0000200 + SCTID:244448001 + TAO:0000013 + VHOG:0000076 + Wikipedia:Cranial_nerve_ganglion + XAO:0000027 + ZFA:0000013 cranial ganglion + + + + The groups of nerve cell bodies associated with the twelve cranial nerves. + ISBN:0-683-40008-8 + MGI:csmith + MP:0001081 + PMID:9362461 + @@ -109492,8 +166235,22 @@ + An anatomical space that is enclosed by a pharynx. + AAO:0010435 + BSA:0000113 + BTO:0002097 + EMAPA:18381 + FMA:54935 + SCTID:180543003 + XAO:0000105 cavity of pharynx + + + + An anatomical space that is enclosed by a pharynx. + OBOL:automatic + @@ -109513,8 +166270,28 @@ + The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens. + BTO:0002084 + EHDAA2:0000129 + EHDAA:9033 + EMAPA:18231 + FMA:58078 + GAID:889 + MA:0000262 + MESH:D000867 + NCIT:C12667 + SCTID:181160009 + VHOG:0001431 + Wikipedia:Anterior_chamber_of_eyeball anterior chamber of eyeball + + + + The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens. + MESH:A09.371.060.067 + MP:0005205 + @@ -109554,8 +166331,25 @@ + The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]. + CALOHA:TS-2228 + EMAPA:35901 + FMA:58103 + GAID:912 + MA:0002480 + MESH:D014602 + NCIT:C12811 + SCTID:280648000 + Wikipedia:Uvea uvea + + + + The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]. + MP:0005197 + Wikipedia:Uvea + @@ -109582,9 +166376,33 @@ - + The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye. + AAO:0010347 + BTO:0000653 + CALOHA:TS-0491 + EFO:0004245 + EMAPA:19154 + EV:0100345 + FMA:58235 + GAID:917 + MA:0000273 + MESH:D007498 + NCIT:C12737 + SCTID:181164000 + TAO:0001238 + VHOG:0000101 + Wikipedia:Iris_(anatomy) + XAO:0000185 + ZFA:0001238 iris + + + + The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye. + ISBN:0-683-40008-8 + MP:0001322 + @@ -109622,9 +166440,31 @@ - + The smooth stratified squamous epithelium that covers the outer surface of the cornea. + BTO:0000287 + CALOHA:TS-0173 + EFO:0001917 + EHDAA2:0000319 + EMAPA:17162 + FMA:58263 + GAID:895 + MA:0001243 + MESH:D019573 + NCIT:C12928 + SCTID:368825001 + TAO:0002187 + Wikipedia:Corneal_epithelium + ZFA:0001683 corneal epithelium + + + + The smooth stratified squamous epithelium that covers the outer surface of the cornea. + MESH:A09.371.060.217.325 + MGI:smb + MP:0006000 + @@ -109663,9 +166503,31 @@ - + Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]. + AAO:0010354 + BTO:0001606 + EMAPA:19027 + EV:0100342 + FMA:58269 + GAID:911 + MA:0000280 + MESH:D012590 + NCIT:C12784 + SCTID:181163006 + VHOG:0001274 + Wikipedia:Sclera + XAO:0000183 + ZFA:0005563 + Disease notes: implicated in rheumatoid arthritis. sclera + + + + Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]. + Wikipedia:Sclera + ZFIN:ZDB-PUB-050701-15 + @@ -109691,8 +166553,22 @@ + A skeletal muscle organ that is part of the trunk region. + AAO:0000611 + EMAPA:35888 + FMA:58274 + MA:0000514 + TAO:0000473 + XAO:0003230 + ZFA:0000473 skeletal muscle of trunk + + + + A skeletal muscle organ that is part of the trunk region. + http://orcid.org/0000-0002-6601-2165 + @@ -109731,9 +166607,32 @@ - + The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes. + AAO:0010341 + BTO:0000260 + CALOHA:TS-0694 + EMAPA:19065 + EV:0100346 + FMA:58295 + GAID:916 + MA:0000264 + MESH:D002924 + NCIT:C12345 + SCTID:263340007 + VHOG:0000102 + Wikipedia:Ciliary_body + XAO:0000186 + neuronames:1571 ciliary body + + + + The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes. + ISBN:0-683-40008-8 + MP:0005099 + Wikipedia:Ciliary_body + @@ -109783,9 +166682,29 @@ - + Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]. + BTO:0001829 + CALOHA:TS-2054 + EMAPA:19077 + EV:0100347 + FMA:58298 + GAID:913 + MA:0000263 + MESH:D002829 + NCIT:C12344 + SCTID:181172003 + TAO:0005229 + VHOG:0001568 + Wikipedia:Choroid + ZFA:0005229 optic choroid + + + + Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]. + Wikipedia:Choroid + @@ -109835,8 +166754,29 @@ + The lamellated connective tissue of the cornea between the Bowman and Descemet membranes. + CALOHA:TS-1138 + EFO:0002514 + EMAPA:17602 + FMA:58306 + GAID:893 + MA:0001245 + MESH:D003319 + NCIT:C12699 + SCTID:362511000 + TAO:0002189 + Wikipedia:Corneal_stroma + ZFA:0001685 substantia propria of cornea + + + + The lamellated connective tissue of the cornea between the Bowman and Descemet membranes. + ISBN:0-683-40008-8 + MESH:A09.371.060.217.228 + MP:0005300 + @@ -109874,9 +166814,23 @@ - + A double layer covering the ciliary body that produces aqueous humor. + BTO:0001770 + CALOHA:TS-0695 + EMAPA:35239 + FMA:58464 + MA:0001238 + NCIT:C32314 + SCTID:280870004 + Wikipedia:Ciliary_body#Ciliary_epithelium ciliary epithelium + + + + A double layer covering the ciliary body that produces aqueous humor. + Wikipedia:Ciliary_body#Ciliary_epithelium + @@ -109908,8 +166862,22 @@ + The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae. + EMAPA:35451 + FMA:58526 + MA:0002777 + SCTID:280882008 + Wikipedia:Iris_stroma + ZFA:0005569 iris stroma + + + + The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae. + Wikipedia:Iris_stroma + http://www.drugs.com/dict/stroma-of-iris.html + @@ -109934,9 +166902,31 @@ - + The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]. + AAO:0011101 + BAMS:spin + BTO:0000870 + EHDAA2:0001898 + EMAPA:16989 + FMA:5858 + GAID:841 + MA:0000233 + MESH:D013127 + NCIT:C12792 + SCTID:361099009 + VHOG:0000824 + Wikipedia:Spinal_nerve + XAO:0003101 + neuronames:1228 spinal nerve + + + + The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]. + MESH:A08.800.800.720 + MP:0001077 + @@ -109957,8 +166947,22 @@ + Any of the layers that make up the retina[MP]. + AAO:0010353 + EMAPA:35742 + FMA:58617 + MA:0001319 + NCIT:C49328 + SCTID:280657006 + XAO:0000266 layer of retina + + + + Any of the layers that make up the retina[MP]. + MP:0003727 + @@ -109994,9 +166998,35 @@ - + Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord. + AAO:0000108 + BAMS:cran + BIRNLEX:1623 + BTO:0001104 + EHDAA2:0000323 + EMAPA:17264 + FMA:5865 + GAID:802 + MA:0000215 + MBA:967 + MESH:D003391 + NCIT:C12700 + SCTID:244447006 + TAO:0000641 + VHOG:0000279 + Wikipedia:Cranial_nerve + XAO:0000429 + XAO:0003089 + ZFA:0000641 + neuronames:1227 cranial nerve + + + + Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord. + Wikipedia:Cranial_nerve + @@ -110017,8 +167047,28 @@ + A thick watery refractive medium that fills the space between the lens and the cornea[WP]. + EHDAA2:0000139 + EHDAA:10196 + EMAPA:18232 + ENVO:02000024 + FMA:58819 + GAID:890 + MA:0001236 + MESH:D001082 + NCIT:C13190 + SCTID:280587006 + VHOG:0000548 + Wikipedia:Aqueous_humor + ZFA:0005564 aqueous humor of eyeball + + + + A thick watery refractive medium that fills the space between the lens and the cornea[WP]. + Wikipedia:Aqueous_humor + @@ -110043,9 +167093,22 @@ - + The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells. + AEO:0001000 + BTO:0005630 + EMAPA:36596 + FMA:5885 + MA:0002566 + MESH:D017950 + NCIT:C13060 sensory ganglion + + + + The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells. + MP:0000960 + @@ -110072,8 +167135,25 @@ + Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive). + EMAPA:36594 + FMA:58865 + MA:0002484 + MESH:D000869 + NCIT:C12668 + SCTID:280658001 + Wikipedia:Anterior_segment_of_eyeball + ZFA:0005566 anterior segment of eyeball + + + + Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive). + ISBN:0-683-40008-8 + MESH:A09.371.060 + MP:0005193 + @@ -110100,8 +167180,23 @@ + Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive). + EMAPA:36595 + FMA:58868 + MA:0002485 + NCIT:C12906 + SCTID:280659009 + Wikipedia:Posterior_segment_of_eyeball + ZFA:0005567 posterior segment of eyeball + + + + Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive). + ISBN:0-683-40008-8 + MP:0005195 + @@ -110133,9 +167228,25 @@ - + A layer of epithelial cells that is part of the eye. + BTO:0001873 + CALOHA:TS-0543 + EMAPA:32871 + FMA:58871 + MA:0001301 + SCTID:362523006 + TAO:0001326 + Wikipedia:Lens_(anatomy)#Lens_Epithelium + XAO:0004094 + ZFA:0001326 epithelium of lens + + + + A layer of epithelial cells that is part of the eye. + http://orcid.org/0000-0002-6601-2165 + @@ -110185,8 +167296,26 @@ + The elastic, clear, membrane-like structure, that is outer most layer of the lens. + EHDAA2:0000977 + EMAPA:18237 + FMA:58881 + MA:0001300 + NCIT:C32975 + SCTID:244500004 + VHOG:0000550 + Wikipedia:Lens_(anatomy)#Lens_capsule + ZFA:0005574 capsule of lens + + + + The elastic, clear, membrane-like structure, that is outer most layer of the lens. + MGI:smb + MP:0003236 + PMID:15483628 + @@ -110217,9 +167346,23 @@ - + Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion. + AEO:0001001 + CALOHA:TS-2340 + EMAPA:18221 + FMA:5889 + MA:0000220 + MESH:D005725 + NCIT:C12720 + Wikipedia:Autonomic_ganglion autonomic ganglion + + + + Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion. + Wikipedia:Autonomic_ganglion + @@ -110263,8 +167406,26 @@ + A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia. + AAO:0010773 + BTO:0001333 + CALOHA:TS-0994 + EHDAA2:0001969 + EMAPA:17157 + FMA:5890 + MA:0000226 + NCIT:C12467 + SCTID:362485003 + Wikipedia:Sympathetic_ganglion sympathetic ganglion + + + + A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia. + MP:0001008 + http://orcid.org/0000-0002-6601-2165 + @@ -110290,8 +167451,78 @@ + One of the two fleshy folds which surround the opening of the mouth. + BTO:0001647 + CALOHA:TS-0558 + EMAPA:32839 + FMA:59816 + GAID:76 + MA:0000343 + MESH:D008046 + NCIT:C12220 + SCTID:181221003 + TAO:0007006 + VHOG:0000677 + Wikipedia:Lip + ZFA:0007006 + galen:Lip lip + + + + One of the two fleshy folds which surround the opening of the mouth. + Wikipedia:Lip + http://www.medterms.com/script/main/art.asp?articlekey=9458 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Lip that covers the upper portion of the mouth.[TAO]. + EMAPA:17925 + FMA:59817 + MA:0000919 + SCTID:245776003 + TAO:0001970 + VHOG:0001750 + Wikipedia:Upper_lip + ZFA:0005226 + upper lip + + + + + Lip that covers the upper portion of the mouth.[TAO]. + TAO:0001970 + Wikipedia:Upper_lip + @@ -110322,8 +167553,24 @@ + Lip that covers the lower portion of the mouth.[TAO]. + EMAPA:17909 + FMA:59818 + MA:0000921 + NCIT:C94572 + SCTID:245777007 + TAO:0002060 + Wikipedia:Lower_lip + ZFA:0005225 lower lip + + + + Lip that covers the lower portion of the mouth.[TAO]. + TAO:0002060 + Wikipedia:Lower_lip + @@ -110354,9 +167601,27 @@ - + A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. + BAMS:phn + BTO:0001063 + EHDAA:4677 + EMAPA:17813 + FMA:6191 + GAID:848 + MA:0001170 + MESH:D010791 + NCIT:C52813 + SCTID:280344009 + VHOG:0000728 + Wikipedia:Phrenic_nerve phrenic nerve + + + + A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. + VHOG:0000728 + @@ -110383,9 +167648,43 @@ - + The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. + AAO:0010149 + BAMS:MES + BIRNLEX:1667 + BM:MB + BTO:0000138 + CALOHA:TS-0630 + DHBA:10648 + DMBA:16649 + EFO:0000919 + EHDAA2:0001162 + EHDAA:3694 + EMAPA:16974 + EV:0100242 + FMA:61993 + HBA:9001 + MA:0000207 + MAT:0000106 + MBA:313 + MESH:D008636 + MIAA:0000106 + NCIT:C12510 + RETIRED_EHDAA2:0001104 + SCTID:279099009 + TAO:0000128 + VHOG:0000069 + Wikipedia:Midbrain + XAO:0000014 + ZFA:0000128 midbrain + + + + The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. + GO:0030901 + @@ -110410,8 +167709,28 @@ + A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]. + DHBA:12664 + EFO:0003617 + EMAPA:16148 + FMA:295666 + MAT:0000272 + MIAA:0000272 + RETIRED_EHDAA2:0000669 + TAO:0001064 + VHOG:0000672 + Wikipedia:Rhombomere + XAO:0004079 + ZFA:0001064 rhombomere + + + + A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]. + Wikipedia:Rhombomere + ZFIN:curator + @@ -110431,8 +167750,33 @@ + Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]. + BAMS:Met + BIRNLEX:965 + BTO:0000673 + CALOHA:TS-2029 + DHBA:10655 + EHDAA2:0001149 + EHDAA:5498 + EMAPA:17071 + FMA:62003 + GAID:594 + HBA:4833 + MA:0000197 + MESH:D020540 + NCIT:C32741 + VHOG:0000741 + Wikipedia:Metencephalon + the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA]. metencephalon + + + + Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]. + Wikipedia:Metencephalon + https://github.com/obophenotype/uberon/issues/300 + @@ -110471,9 +167815,45 @@ - + Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. + AAO:0010486 + BAMS:MY + BAMS:Md + BIRNLEX:957 + BM:Me + BTO:0000041 + CALOHA:TS-0607 + DMBA:17352 + EFO:0000924 + EHDAA2:0001088 + EHDAA:7588 + EMAPA:17550 + EV:0100275 + FMA:62004 + GAID:590 + MA:0000206 + MAT:0000111 + MAT:0000367 + MBA:354 + MESH:D008526 + MIAA:0000111 + NCIT:C12442 + SCTID:279104005 + TAO:0000545 + VHOG:0000181 + Wikipedia:Bone_marrow_of_ovary_oblongata + XAO:0003100 + ZFA:0000545 medulla oblongata + + + + Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. + FMA:62004 + GO:0021550 + Wikipedia:Bone_marrow_of_ovary_oblongata + @@ -110510,9 +167890,74 @@ - + The epithelial lining of the trachea which contains numerous ciliated cells. + BTO:0001389 + CALOHA:TS-1061 + EHDAA2:0002069 + EHDAA:5007 + EMAPA:16855 + EMAPA:18409 + FMA:62015 + MA:0001862 + NCIT:C33797 + VHOG:0001045 epithelium of trachea + + + + The epithelial lining of the trachea which contains numerous ciliated cells. + ISBN:0-397-51047-0 + MGI:cwg + MP:0002285 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a small intestine [Automatically generated definition]. + BTO:0001258 + CALOHA:TS-2104 + EMAPA:35778 + FMA:62017 + MA:0001553 + SCTID:45480009 + TAO:0005127 + ZFA:0005127 + epithelium of small intestine + + + + + An epithelium that is part of a small intestine [Automatically generated definition]. + OBOL:automatic + @@ -110537,8 +167982,21 @@ + An endothelium that is part of a capillary [Automatically generated definition]. + BTO:0004954 + CALOHA:TS-0112 + EMAPA:36292 + FMA:62114 + MA:0000711 + NCIT:C49215 endothelium of capillary + + + + An endothelium that is part of a capillary [Automatically generated definition]. + OBOL:automatic + @@ -110564,8 +168022,19 @@ + An endothelium that is part of an arteriole [Automatically generated definition]. + EMAPA:36286 + FMA:62115 + MA:0000705 + NCIT:C49192 endothelium of arteriole + + + + An endothelium that is part of an arteriole [Automatically generated definition]. + OBOL:automatic + @@ -110592,8 +168061,23 @@ + An endothelium that is part of an artery [Automatically generated definition]. + AAO:0011013 + BTO:0004757 + EMAPA:35148 + FMA:62116 + MA:0000707 + NCIT:C49194 + VHOG:0001215 + XAO:0000357 endothelium of artery + + + + An endothelium that is part of an artery [Automatically generated definition]. + OBOL:automatic + @@ -110619,8 +168103,19 @@ + An endothelium that is part of a venule [Automatically generated definition]. + EMAPA:36290 + FMA:62117 + MA:0000716 + NCIT:C49319 endothelium of venule + + + + An endothelium that is part of a venule [Automatically generated definition]. + OBOL:automatic + @@ -110646,8 +168141,23 @@ + An endothelium that is part of a vein [Automatically generated definition]. + AAO:0011110 + BTO:0004756 + EMAPA:36288 + FMA:62118 + MA:0000712 + NCIT:C49317 + VHOG:0001216 + XAO:0000358 endothelium of vein + + + + An endothelium that is part of a vein [Automatically generated definition]. + OBOL:automatic + @@ -110673,9 +168183,35 @@ - + Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. + BAMS:MTg + BIRNLEX:1200 + BTO:0003388 + DHBA:12195 + EFO:0000921 + EHDAA2:0004475 + EMAPA:18215 + FMA:62393 + HBA:9002 + MA:0000212 + MAT:0000452 + SCTID:362392007 + TAO:0000160 + VHOG:0001367 + Wikipedia:Midbrain_tegmentum + XAO:0004271 + ZFA:0000160 + 'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum midbrain tegmentum + + + + Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. + FMA:FMA + ISBN:0471888893 + Wikipedia:Midbrain_tegmentum + @@ -110701,8 +168237,18 @@ + A multi-tissue structure that is part of a spinal cord. + BIRNLEX:1496 + NCIT:C33969 + SCTID:244437008 regional part of spinal cord + + + + A multi-tissue structure that is part of a spinal cord. + OBOL:automatic + @@ -110727,9 +168273,19 @@ - + An epithelium that is part of a respiratory bronchiole [Automatically generated definition]. + EMAPA:35730 + FMA:62498 + MA:0001773 + NCIT:C48943 epithelium of respiratory bronchiole + + + + An epithelium that is part of a respiratory bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -110772,9 +168328,20 @@ - + The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]. + EMAPA:35192 + FMA:62649 + MA:0001835 + NCIT:C49209 + SCTID:278980009 cartilage of bronchus + + + + The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP]. + MP:0010988 + @@ -110800,8 +168367,20 @@ + A submucosa that is part of a bronchus [Automatically generated definition]. + BTO:0002108 + FMA:62653 + MA:0001837 + NCIT:C49214 + SCTID:85546005 submucosa of bronchus + + + + A submucosa that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -110826,9 +168405,19 @@ - + An epithelium that lines a terminal bronchiole. + EMAPA:36283 + FMA:62794 + MA:0001774 + NCIT:C33755 terminal bronchiole epithelium + + + + An epithelium that lines a terminal bronchiole. + http://orcid.org/0000-0002-6601-2165 + @@ -110877,8 +168466,103 @@ + The liquid component of blood, in which erythrocytes are suspended. + BTO:0000131 + CALOHA:TS-0800 + EFO:0001905 + EMAPA:35690 + FMA:62970 + GAID:1178 + MA:0002501 + MAT:0000052 + MESH:D010949 + MIAA:0000052 + NCIT:C13356 + Wikipedia:Blood_plasma blood plasma + + + + The liquid component of blood, in which erythrocytes are suspended. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium. + BTO:0000121 + CALOHA:TS-1172 + ENVO:02000023 + FMA:62971 + GAID:1157 + MA:0002513 + MESH:D001646 + NCIT:C13192 + Wikipedia:Bile + ZFA:0005857 + galen:Bile + bile + + + + + Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium. + DOI:10.1002/cphy.c120027 + Wikipedia:Bile + @@ -110903,6 +168587,14 @@ + BTO:0000501 + FMA:62972 + GAID:1160 + MA:0002519 + MESH:D005750 + NCIT:C32661 + Wikipedia:Gastric_juice + galen:GastricJuice gastric juice @@ -110929,8 +168621,20 @@ + A submucosa that is part of a esophagus [Automatically generated definition]. + BTO:0002109 + EMAPA:35325 + FMA:62997 + MA:0002724 + SCTID:362128009 submucosa of esophagus + + + + A submucosa that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -110955,8 +168659,19 @@ + A lamina propria that is part of a esophagus [Automatically generated definition]. + EMAPA:26987 + FMA:63050 + MA:0001568 + NCIT:C49223 lamina propria of esophagus + + + + A lamina propria that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -110981,8 +168696,18 @@ + A serous membrane that is part of a esophagus [Automatically generated definition]. + EMAPA:35322 + FMA:63057 + MA:0001571 serosa of esophagus + + + + A serous membrane that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -111014,8 +168739,57 @@ + The epithelial layer that lines the luminal space of the esophagus. + BTO:0001578 + CALOHA:TS-0698 + EFO:0003041 + EHDAA2:0001287 + EMAPA:16835 + FMA:63063 + MA:0001565 + NCIT:C49221 + TAO:0001499 + ZFA:0001499 epithelium of esophagus + + + + The epithelial layer that lines the luminal space of the esophagus. + ISBN:0-683-40008-8 + MP:0000468 + + + + + + + + + + + + + + + + + + + + + + + + + + EMAPA:32925 + FMA:63120 + MA:0000724 + SCTID:371401008 + VHOG:0001430 + parenchyma of pancreas + @@ -111036,9 +168810,27 @@ - + One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins. + BTO:0002626 + EMAPA:35917 + FMA:63130 + MA:0000071 + MESH:D014699 + NCIT:C12818 + SCTID:341687009 + TAO:0005315 + VHOG:0001765 + Wikipedia:Venule + ZFA:0005315 venule + + + + One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins. + MESH:A07.231.432.952 + MP:0004125 + @@ -111080,8 +168872,27 @@ + The smallest division of the artery located between the muscular arteries and the capillaries[GO]. + AAO:0010253 + BTO:0001997 + EMAPA:35146 + FMA:63182 + MA:0000063 + MESH:D001160 + NCIT:C12672 + SCTID:337724002 + TAO:0002138 + VHOG:0001763 + Wikipedia:Arteriole + ZFA:0005255 arteriole + + + + The smallest division of the artery located between the muscular arteries and the capillaries[GO]. + GO:0014830 + @@ -111138,9 +168949,39 @@ - + A vessel through which blood circulates in the body. + AAO:0011004 + AEO:0000207 + BTO:0001102 + CALOHA:TS-0080 + EFO:0000817 + EHDAA2:0003252 + EHDAA:240 + EMAPA:32743 + EMAPA:35993 + FMA:50722 + FMA:63183 + GAID:169 + MA:0000060 + MAT:0000393 + MESH:D001808 + NCIT:C12679 + NLXANAT:090901 + SCTID:361097006 + TAO:0002137 + VHOG:0001250 + Wikipedia:Blood_vessel + XAO:0001011 + ZFA:0005314 blood vessel + + + + A vessel through which blood circulates in the body. + BTO:0001102 + Wikipedia:Blood_vessel + @@ -111175,9 +169016,33 @@ - + Any of the smallest blood vessels connecting arterioles with venules. + AAO:0010252 + BTO:0002045 + CALOHA:TS-2006 + EFO:0001906 + EMAPA:35198 + EV:0100035 + FMA:63194 + MA:0000065 + MESH:D002196 + NCIT:C12685 + NLXANAT:090902 + TAO:0005250 + VHOG:0001253 + Wikipedia:Capillary + XAO:0000116 + ZFA:0005250 capillary + + + + Any of the smallest blood vessels connecting arterioles with venules. + ISBN:0073040584 + Wikipedia:Capillary + https://github.com/obophenotype/uberon/issues/137 + @@ -111216,9 +169081,26 @@ - + A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]. + CALOHA:TS-0172 + EMAPA:35935 + FMA:63882 + GAID:891 + MA:0001242 + MESH:D004728 + NCIT:C12707 + SCTID:368827009 + TAO:0002186 + Wikipedia:Corneal_endothelium + ZFA:0001687 corneal endothelium + + + + A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]. + Wikipedia:Corneal_endothelium + @@ -111250,9 +169132,73 @@ - + A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]. + BTO:0000393 + CALOHA:TS-0278 + EFO:0002548 + FMA:63916 + GAID:520 + MESH:D004727 + NCIT:C12481 + SCTID:27168002 + galen:Endothelium + The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980) endothelium + + + + A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]. + FMA:63916 + MESH:A10.272.491 + https://github.com/obophenotype/uberon/issues/225 + + + + + + + + + + + + + + + + + + + + + + + + + + Portion of semisolid bodily waste discharged through the anus[MW,modified]. + BTO:0000440 + CALOHA:TS-2345 + ENVO:00002003 + FMA:64183 + GAID:1199 + MA:0002509 + MAT:0000053 + MESH:D005243 + MIAA:0000053 + NCIT:C13234 + Wikipedia:Feces + galen:Feces + feces + + + + + Portion of semisolid bodily waste discharged through the anus[MW,modified]. + Wikipedia:Feces + http://www.merriam-webster.com/dictionary/feces + @@ -111266,8 +169212,26 @@ + Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance. + EMAPA:35414 + FMA:64783 + MA:0000109 + NCIT:C32746 + SCTID:39298000 + VSAO:0000094 + Wikipedia:Hyaline_cartilage + XAO:0004029 hyaline cartilage tissue + + + + Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000094 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -111328,9 +169292,33 @@ - + An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.. + AAO:0010221 + BTO:0000778 + CALOHA:TS-0839 + EFO:0001399 + EHDAA2:0001575 + EHDAA:4351 + EMAPA:17008 + FMA:66326 + GAID:505 + MA:0002031 + MESH:D011651 + NCIT:C12774 + SCTID:181380003 + VHOG:0000982 + Wikipedia:Pulmonary_artery + XAO:0004162 + galen:PulmonaryArtery pulmonary artery + + + + An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.. + Wikipedia:Pulmonary_artery + http://orcid.org/0000-0002-6601-2165 + @@ -111374,9 +169362,67 @@ - + Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]. + AAO:0010521 + BTO:0001799 + CALOHA:TS-0840 + EHDAA2:0001579 + EHDAA:2629 + EMAPA:18645 + FMA:66643 + GAID:543 + MA:0002206 + MESH:D011667 + NCIT:C12776 + SCTID:430160002 + VHOG:0001133 + Wikipedia:Pulmonary_vein + XAO:0000394 + galen:PulmonaryVein pulmonary vein + + + + Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]. + GO:0060577 + + + + + + + + + + + + + + + A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]. + BTO:0001792 + CALOHA:TS-0814 + EHDAA2:0001485 + EHDAA:6510 + EMAPA:17349 + FMA:66645 + GAID:540 + MA:0002198 + MESH:D011169 + NCIT:C33343 + SCTID:362064007 + VHOG:0000656 + XAO:0000392 + galen:PortalVein + portal vein + + + + + A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]. + BTO:0001792 + @@ -111390,8 +169436,28 @@ + A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. + AEO:0001012 + EHDAA2:0003136 + EHDAA2_RETIRED:0004658 + FMA:67242 + HBA:4006 + MA:0001112 + NCIT:C32695 + TAO:0002197 + VHOG:0001768 + Wikipedia:Gray_matter + ZFA:0001681 + neuronames:2869 gray matter + + + + A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. + Wikipedia:Gray_matter + http://orcid.org/0000-0002-6601-2165 + @@ -111423,9 +169489,89 @@ - + The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. + AAO:0010150 + BAMS:HB + BIRNLEX:942 + BTO:0000672 + CALOHA:TS-0457 + DHBA:10653 + DMBA:16808 + EFO:0000923 + EHDAA2:0000746 + EHDAA:3514 + EHDAA:6487 + EMAPA:16916 + FMA:67687 + MA:0000195 + MAT:0000107 + MBA:1065 + MESH:D012249 + MIAA:0000107 + NCIT:C40336 + SCTID:303456008 + TAO:0000029 + VHOG:0000070 + Wikipedia:Rhombencephalon + XAO:0000015 + ZFA:0000029 hindbrain + + + + The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. + Wikipedia:Rhombencephalon + ZFA:0000029 + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The simple columnar epithelial lining of the gall bladder. + BTO:0001449 + CALOHA:TS-1304 + EMAPA:35370 + FMA:67711 + MA:0001632 + NCIT:C49227 + epithelium of gall bladder + + + + + The simple columnar epithelial lining of the gall bladder. + MP:0009492 + @@ -111462,8 +169608,22 @@ + An epithelium that is part of a bronchus [Automatically generated definition]. + BTO:0001845 + CALOHA:TS-1240 + EFO:0000307 + EMAPA:32691 + FMA:67782 + MA:0001839 + NCIT:C32231 epithelium of bronchus + + + + An epithelium that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -111488,8 +169648,28 @@ + Muscle tissue that contains fibers that are divided by transverse bands into striations. + AAO:0010762 + AEO:0000140 + CALOHA:TS-2047 + EHDAA2:0003140 + EMAPA:36390 + FMA:67905 + MA:0002438 + NCIT:C12436 + WBbt:0005779 + Wikipedia:Striated_muscle + galen:StriatedMuscle striated muscle tissue + + + + Muscle tissue that contains fibers that are divided by transverse bands into striations. + CL:0000737 + GOC:dph + GOC:mtg_muscle + @@ -111530,9 +169710,25 @@ - + A systemic artery that supplies the lung with with oxygenated blood. + EMAPA:18608 + FMA:68109 + GAID:477 + MA:0001923 + MESH:D001981 + NCIT:C32230 + SCTID:244247009 + Wikipedia:Bronchial_artery + Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung. bronchial artery + + + + A systemic artery that supplies the lung with with oxygenated blood. + UBERON:cjm + Wikipedia:Bronchial_artery + @@ -111553,8 +169749,26 @@ + The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]. + BAMS:PnR + BAMS:RA-PONS + BAMS:RPn + BIRNLEX:1110 + DHBA:12471 + DHBA:12475 + FMA:68875 + HBA:9159 + MA:0001022 + MBA:238 + Wikipedia:Pontine_raphe_nucleus pontine raphe nucleus + + + + The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]. + Wikipedia:Pontine_raphe_nucleus + @@ -111595,9 +169809,37 @@ - + Respiration organ that develops as an outpocketing of the esophagus. + AAO:0000275 + AAO:0010567 + BTO:0000763 + CALOHA:TS-0568 + EFO:0000934 + EHDAA2:0001042 + EHDAA:1554 + EHDAA:2205 + EMAPA:16728 + EV:0100042 + FMA:7195 + GAID:345 + MA:0000415 + MAT:0000135 + MESH:D008168 + MIAA:0000135 + NCIT:C12468 + SCTID:181216001 + Wikipedia:Lung + XAO:0000119 + galen:Lung + Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP] lung + + + + Respiration organ that develops as an outpocketing of the esophagus. + http://orcid.org/0000-0002-6601-2165 + @@ -111623,9 +169865,19 @@ - + An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. + BTO:0003718 + FMA:69050 + TAO:0005249 + ZFA:0005249 vasculature + + + + An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. + ZFA:0005249 + @@ -111650,8 +169902,31 @@ + Anatomical structure that is part of an embryo. + AAO:0000138 + BILA:0000034 + BTO:0000174 + CALOHA:TS-2110 + EFO:0000461 + FMA:69067 + GAID:407 + MESH:D004628 + NCIT:C13229 + RETIRED_EHDAA2:0003169 + SCTID:667009 + TAO:0001105 + VSAO:0000178 + XAO:0003042 + ZFA:0001105 embryonic structure + + + + Anatomical structure that is part of an embryo. + BTO:0000174 + ZFIN:curator + @@ -111702,9 +169977,21 @@ - + An epithelium that is part of a bronchiole [Automatically generated definition]. + BTO:0001866 + CALOHA:TS-0570 + EMAPA:32693 + FMA:69077 + MA:0001772 + NCIT:C48942 epithelium of bronchiole + + + + An epithelium that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -111729,8 +170016,18 @@ + An artery that supplies the diaphragm. + FMA:69330 + MA:0002019 + NCIT:C33320 phrenic artery + + + + An artery that supplies the diaphragm. + https://orcid.org/0000-0002-6601-2165 + @@ -111758,8 +170055,24 @@ + The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles. + EHDAA2:0004143 + EMAPA:35887 + FMA:70301 + GAID:554 + MA:0000103 + MESH:D014338 + NCIT:C34317 + SCTID:308828009 + Wikipedia:Truncus_arteriosus_(embryology) truncus arteriosus + + + + The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles. + Wikipedia:Truncus_arteriosus_(embryology) + @@ -111776,8 +170089,29 @@ + The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]. + EHDAA2:0000434 + EHDAA2:0004028 + EHDAA:2586 + EMAPA:16696 + FMA:70302 + MA:0000078 + TAO:0001317 + VHOG:0000932 + Wikipedia:Atrioventricular_cushions + XAO:0004189 + ZFA:0001317 + GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form endocardial cushion + + + + The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]. + GO:0003197 + Wikipedia:Atrioventricular_cushions + ZFIN:curator + @@ -111797,8 +170131,27 @@ + The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart. + AAO:0010505 + EHDAA2:0001839 + EHDAA:480 + EMAPA:16237 + FMA:70303 + NCIT:C34299 + NCIT:C34300 + TAO:0000154 + VHOG:0000177 + Wikipedia:Sinus_venosus + ZFA:0000154 sinus venosus + + + + The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart. + PMID:20735616 + Wikipedia:Sinus_venosus + @@ -111850,9 +170203,35 @@ - + The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. + AAO:0000128 + BTO:0000294 + CALOHA:TS-2076 + EFO:0000953 + EMAPA:17527 + EV:0100154 + FMA:70323 + GAID:1321 + MA:0000152 + MAT:0000153 + MESH:D020405 + MIAA:0000153 + NCIT:C12701 + SCTID:361696001 + TAO:0001119 + VHOG:0000108 + Wikipedia:Dermis + XAO:0000217 + ZFA:0001119 dermis + + + + The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. + Wikipedia:Dermis + ZFIN:curator + @@ -111891,9 +170270,22 @@ - + Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. + BTO:0001314 + CALOHA:TS-2366 + FMA:70544 + NCIT:C33645 + TAO:0001136 + Wikipedia:Hypodermis + ZFA:0001136 hypodermis + + + + Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. + Wikipedia:Hypodermis + @@ -111918,8 +170310,29 @@ + An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen. + AAO:0010386 + BTO:0001491 + EHDAA:512 + EMAPA:16245 + FMA:7085 + MA:0000019 + MESH:D014781 + NCIT:C28287 + RETIRED_EHDAA2:0002201 + SCTID:118760003 + Wikipedia:Viscus + XAO:0003034 viscus + + + + An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen. + BTO:0001491 + Wikipedia:Viscus + https://github.com/obophenotype/mouse-anatomy-ontology/issues/14 + @@ -111945,9 +170358,28 @@ - + A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. + AAO:0010248 + BTO:0001703 + EHDAA2:0000290 + EMAPA:17321 + FMA:7096 + MA:0000075 + NCIT:C12868 + SCTID:244383003 + VHOG:0000328 + Wikipedia:Right_atrium + XAO:0003192 + galen:RightAtrium right cardiac atrium + + + + A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. + Wikipedia:Right_atrium + http://orcid.org/0000-0002-6601-2165 + @@ -111973,9 +170405,28 @@ - + A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve. + AAO:0010247 + BTO:0001702 + EHDAA2:0000275 + EMAPA:17315 + FMA:7097 + MA:0000074 + NCIT:C12869 + SCTID:244387002 + VHOG:0000369 + Wikipedia:Left_atrium + XAO:0003191 + galen:LeftAtrium left cardiac atrium + + + + A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve. + Wikipedia:Left_atrium + http://orcid.org/0000-0002-6601-2165 + @@ -112013,9 +170464,26 @@ - + A cardiac ventricle that is in the right side of the heart. + BTO:0001630 + CALOHA:TS-0443 + EHDAA2:0000196 + EMAPA:17340 + FMA:7098 + MA:0000093 + NCIT:C12870 + SCTID:244384009 + VHOG:0000717 + Wikipedia:Right_ventricle + galen:RightVentricle heart right ventricle + + + + A cardiac ventricle that is in the right side of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -112035,8 +170503,36 @@ + Cardiac chamber in which blood enters the heart. + AAO:0010246 + BTO:0000903 + CALOHA:TS-0437 + EFO:0000277 + EHDAA2:0000154 + EHDAA:1265 + EMAPA:16688 + EV:0100019 + FMA:7099 + GAID:555 + MA:0000073 + MAT:0000496 + MESH:D006325 + NCIT:C12728 + SCTID:261405004 + TAO:0000471 + VHOG:0000175 + Wikipedia:Heart_atrium + ZFA:0000471 + galen:Atrium cardiac atrium + + + + Cardiac chamber in which blood enters the heart. + Wikipedia:Heart_atrium + http://orcid.org/0000-0002-6601-2165 + @@ -112056,8 +170552,37 @@ + Cardiac chamber through which blood leaves the heart. + AAO:0010249 + BTO:0000862 + CALOHA:TS-0444 + EFO:0000317 + EHDAA2:0004164 + EHDAA:1912 + EMAPA:17331 + EV:0100020 + FMA:7100 + GAID:568 + MA:0000091 + MAT:0000497 + MESH:D006352 + NCIT:C12730 + SCTID:277699000 + TAO:0000009 + VHOG:0000435 + Wikipedia:Ventricle_(heart) + XAO:0003193 + ZFA:0000009 + galen:Ventricle cardiac ventricle + + + + Cardiac chamber through which blood leaves the heart. + Wikipedia:Ventricle_(heart) + http://orcid.org/0000-0002-6601-2165 + @@ -112095,9 +170620,26 @@ - + A cardiac ventricle that is in the left side of the heart. + BTO:0001629 + CALOHA:TS-0439 + EHDAA2:0002178 + EMAPA:17337 + FMA:7101 + MA:0000092 + NCIT:C12871 + SCTID:244385005 + VHOG:0000718 + Wikipedia:Left_ventricle + galen:LeftVentricle heart left ventricle + + + + A cardiac ventricle that is in the left side of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -112132,8 +170674,25 @@ + A cardiac septum that divides the left and right atria of the heart. + EHDAA2:0000838 + EHDAA:1896 + EMAPA:17011 + FMA:7108 + MA:0000084 + NCIT:C32818 + SCTID:362016003 + VHOG:0000385 + Wikipedia:Interatrial_septum + galen:InteratrialSeptum interatrial septum + + + + A cardiac septum that divides the left and right atria of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -112159,8 +170718,31 @@ + The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. + AAO:0000034 + EFO:0000942 + EHDAA2:0000161 + EHDAA:5049 + FMA:71221 + MA:0002986 + MAT:0000148 + MIAA:0000148 + TAO:0000317 + VHOG:0000317 + VSAO:0000093 + XAO:0003073 + ZFA:0000317 + previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed. postcranial axial skeleton + + + + The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. + ZFA:0000317 + https://sourceforge.net/tracker/?func=detail&aid=2983975&group_id=76834&atid=974957 + https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=2983977&group_id=76834 + @@ -112192,9 +170774,29 @@ - + Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]. + AAO:0000747 + EFO:0000951 + EMAPA:32729 + FMA:71222 + MA:0000290 + MAT:0000278 + MIAA:0000278 + NCIT:C49477 + SCTID:322050006 + VSAO:0000076 + Wikipedia:Appendicular_skeleton + XAO:0003166 appendicular skeleton + + + + Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]. + UBERONREF:0000003 + Wikipedia:Appendicular_skeleton + https://orcid.org/0000-0002-6601-2165 + @@ -112229,9 +170831,61 @@ - + Cardiac septum which separates the right ventricle from the left ventricle.[FMA]. + BTO:0002483 + EFO:0001956 + EHDAA:2603 + EMAPA:17333 + FMA:7133 + MA:0000085 + NCIT:C32874 + SCTID:362019005 + VHOG:0000386 + Wikipedia:Interventricular_septum + galen:InterventricularSeptum interventricular septum + + + + Cardiac septum which separates the right ventricle from the left ventricle.[FMA]. + FMA:7133 + + + + + + + + + + + + + + + Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon. + AAO:0011061 + BTO:0001380 + EV:0100083 + FMA:7144 + GAID:21 + MESH:D008643 + NCIT:C33103 + SCTID:362707009 + Wikipedia:Mesentery#Mesentery_.28general.29 + galen:Mesentery + mesentery + + + + + Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon. + FMA:7144 + Wikipedia:Mesentery + Wikipedia:Mesentery#Mesentery_.28general.29 + https://github.com/obophenotype/uberon/issues/85 + @@ -112258,9 +170912,28 @@ - + The organ covering the body that consists of the dermis and epidermis. + BTO:0001253 + CALOHA:TS-0934 + EFO:0000962 + EHDAA2:0001844 + EMAPA:17525 + FMA:7163 + MESH:D012867 + MFMO:0000099 + NCIT:C12470 + SCTID:181469002 + Wikipedia:Skin + XAO:0000023 + galen:Skin skin of body + + + + The organ covering the body that consists of the dermis and epidermis. + UBERON:cjm + @@ -112298,8 +170971,22 @@ + The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles. + EMAPA:35400 + FMA:7180 + GAID:562 + MA:0000083 + MESH:D006346 + NCIT:C49485 + SCTID:362014000 cardiac septum + + + + The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles. + MESH:A07.541.459 + @@ -112313,8 +171000,35 @@ + Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. + AAO:0010339 + BILA:0000116 + BTO:0001493 + CALOHA:TS-1071 + EFO:0000966 + EMAPA:31857 + FMA:7181 + MA:0000004 + MAT:0000296 + MIAA:0000296 + NCIT:C33816 + SCTID:262225004 + TAO:0001115 + Wikipedia:Torso + XAO:0000054 + XAO:0003025 + ZFA:0001115 + galen:Trunk trunk + + + + Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. + TAO:0001115 + UBERONREF:0000006 + Wikipedia:Torso + @@ -112328,8 +171042,27 @@ + The sensory system subserving the sense of vision. + AAO:0000632 + BILA:0000140 + EMAPA:36003 + FMA:7191 + MA:0002444 + NCIT:C12888 + SCTID:281831001 + TAO:0001127 + Wikipedia:Visual_system + XAO:0003198 + ZFA:0001127 + http://uri.neuinfo.org/nif/nifstd/FMAID_7191 visual system + + + + The sensory system subserving the sense of vision. + NIFSTD:FMAID_7191 + @@ -112343,8 +171076,300 @@ + Sensory system responsible for the perception of spatial orientation and auditory stimuli. + AAO:0000631 + FMA:78500 + TAO:0001138 + XAO:0003195 + ZFA:0001138 vestibulo-auditory system + + + + Sensory system responsible for the perception of spatial orientation and auditory stimuli. + ZFA:0001138 + + + + + + + + + + + + + + + + + + + + + + + The organ that functions to filter blood and to store red corpuscles and platelets. + AAO:0010395 + BTO:0001281 + CALOHA:TS-0956 + EFO:0000869 + EMAPA:18767 + EV:0100055 + FMA:7196 + GAID:1289 + MA:0000141 + MAT:0000085 + MESH:D013154 + MIAA:0000085 + NCIT:C12432 + SCTID:181279003 + TAO:0000436 + VHOG:0000120 + Wikipedia:Spleen + XAO:0000328 + ZFA:0000436 + galen:Spleen + spleen + + + + + The organ that functions to filter blood and to store red corpuscles and platelets. + ISBN:0-683-40008-8 + MP:0000689 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. + AAO:0010111 + BTO:0000759 + CALOHA:TS-0564 + EFO:0000887 + EHDAA2:0000997 + EHDAA:2197 + EMAPA:16846 + EV:0100089 + FMA:7197 + GAID:288 + MA:0000358 + MAT:0000097 + MESH:D008099 + MIAA:0000097 + NCIT:C12392 + SCTID:181268008 + TAO:0000123 + VHOG:0000257 + Wikipedia:Liver + XAO:0000133 + ZFA:0000123 + galen:Liver + liver + + + + + An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. + BTO:0000759 + Wikipedia:Liver + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]. + AAO:0010397 + BTO:0000651 + CALOHA:TS-0942 + EFO:0000841 + EMAPA:32834 + EV:0100072 + FMA:7200 + GAID:313 + MA:0000337 + MAT:0000047 + MESH:D007421 + MIAA:0000047 + NCIT:C12386 + SCTID:181250005 + TAO:0001323 + VHOG:0000055 + Wikipedia:Small_intestine + XAO:0000130 + ZFA:0001323 + galen:SmallIntestine + small intestine + + + + + Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]. + ISBN:0073040584 + Wikipedia:Small_intestine + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An organ that aids digestion and stores bile produced by the liver[WP]. + AAO:0010114 + BTO:0000493 + CALOHA:TS-0394 + EFO:0000853 + EHDAA2:0000699 + EHDAA:8062 + EMAPA:17202 + EV:0100090 + FMA:7202 + MA:0000356 + MAT:0000072 + MESH:D005704 + MIAA:0000072 + NCIT:C12377 + SCTID:181269000 + TAO:0000208 + VHOG:0000221 + Wikipedia:Gallbladder + XAO:0000135 + ZFA:0000208 + galen:Gallbladder + Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988) + gallbladder + + + + + An organ that aids digestion and stores bile produced by the liver[WP]. + Wikipedia:Gallbladder + @@ -112370,8 +171395,21 @@ + A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]. + BTO:0000087 + CALOHA:TS-1198 + EMAPA:36285 + FMA:72024 + MA:0000708 + NCIT:C49195 artery smooth muscle tissue + + + + A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]. + OBOL:automatic + @@ -112402,8 +171440,77 @@ + A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]. + EMAPA:35323 + FMA:72025 + MA:0001573 smooth muscle of esophagus + + + + A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). + AAO:0010402 + BTO:0000365 + CALOHA:TS-0214 + EFO:0000851 + EMAPA:18852 + EV:0100073 + FMA:7206 + GAID:284 + MA:0000338 + MAT:0000044 + MESH:D004386 + MIAA:0000044 + NCIT:C12263 + SCTID:181247007 + VHOG:0000052 + Wikipedia:Duodenum + XAO:0000236 + galen:Duodenum + duodenum + + + + + The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). + ISBN:0815318960 + Wikipedia:Duodenum + @@ -112429,8 +171536,19 @@ + An ovary that is part of a right side of organism [Automatically generated definition]. + FMA:7213 + MA:0001705 + NCIT:C33487 + SCTID:280123002 right ovary + + + + An ovary that is part of a right side of organism [Automatically generated definition]. + OBOL:automatic + @@ -112456,8 +171574,19 @@ + An ovary that is part of a left side of organism [Automatically generated definition]. + FMA:7214 + MA:0001704 + NCIT:C32969 + SCTID:280124008 left ovary + + + + An ovary that is part of a left side of organism [Automatically generated definition]. + OBOL:automatic + @@ -112478,8 +171607,27 @@ + A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system. + BAMS:SOC + BIRNLEX:1307 + DHBA:12462 + EMAPA:35840 + EV:0100263 + FMA:72247 + HBA:9177 + MA:0001026 + MBA:398 + VHOG:0001381 + Wikipedia:Superior_olivary_complex superior olivary complex + + + + A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system. + ISBN:0-19-502694-2 + Wikipedia:Superior_olivary_complex + @@ -112501,8 +171649,37 @@ + The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]. + BAMS:CAE + BAMS:LC + BIRNLEX:905 + BM:Pons-LC + BTO:0001408 + DHBA:12819 + DMBA:16972 + EFO:0001963 + EMAPA:35502 + FMA:72478 + GAID:577 + HBA:9148 + MA:0001017 + MBA:147 + MESH:D008125 + NCIT:C97333 + SCTID:369016004 + TAO:0000539 + Wikipedia:Locus_ceruleus + ZFA:0000539 locus ceruleus + + + + The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]. + GAID:577 + GO:0021703 + Wikipedia:Locus_ceruleus + @@ -112524,8 +171701,26 @@ + Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703). + BAMS:SSN + BAMS:SuS + BIRNLEX:1131 + DHBA:12435 + EHDAA2:0004646 + FMA:72482 + HBA:9194 + MA:0001027 + MBA:462 + SCTID:369028007 + Wikipedia:Superior_salivatory_nucleus superior salivatory nucleus + + + + Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703). + BIRNLEX:1131 + @@ -112546,8 +171741,37 @@ + The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]. + AAO:0010408 + BTO:0000387 + CALOHA:TS-2075 + EFO:0000821 + EHDAA2:0004153 + EMAPA:17868 + EMAPA:32686 + EV:0100021 + FMA:7280 + GAID:550 + MA:0000076 + MAT:0000455 + MESH:D004699 + NCIT:C13004 + SCTID:362013006 + TAO:0001320 + VHOG:0000084 + Wikipedia:Endocardium + XAO:0000066 + ZFA:0001320 + galen:Endocardium + fixed in GO to reflect FMA. See email to David/Varsha June 18 2010 endocardium + + + + The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]. + GO:0003157 + @@ -112578,8 +171802,22 @@ + Endocardium that is part of the atrium. + EMAPA:32745 + FMA:7284 + MA:0000077 + SCTID:192001005 + TAO:0002169 + VHOG:0000606 + ZFA:0001614 endocardium of atrium + + + + Endocardium that is part of the atrium. + ZFIN:curator + @@ -112604,8 +171842,25 @@ + Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]. + EHDAA2:0001730 + EHDAA:4969 + EMAPA:17661 + FMA:7309 + MA:0000426 + NCIT:C33483 + SCTID:361967000 + VHOG:0000301 + Wikipedia:Right_lung right lung + + + + Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]. + FMA:FMA + Wikipedia:Right_lung + @@ -112630,8 +171885,25 @@ + Lung which consists of the left upper lobe and left lower lobe.[FMA]. + EHDAA2:0000943 + EHDAA:4947 + EMAPA:17653 + FMA:7310 + MA:0000425 + NCIT:C32967 + SCTID:361982005 + VHOG:0000618 + Wikipedia:Left_lung left lung + + + + Lung which consists of the left upper lobe and left lower lobe.[FMA]. + FMA:FMA + Wikipedia:Left_lung + @@ -112676,8 +171948,23 @@ + The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters. + BTO:0000061 + EMAPA:35119 + FMA:7317 + MA:0000418 + NCIT:C32057 + SCTID:361964007 + Wikipedia:Alveolar_sac alveolar sac + + + + The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters. + MP:0010902 + Wikipedia:Alveolar_sac + @@ -112691,9 +171978,22 @@ - + The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli. + EMAPA:32694 + FMA:7341 + MA:0000417 + NCIT:C32056 + Wikipedia:Alveolar_duct pulmonary alveolar duct + + + + The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli. + ISBN:0-683-40008-8 + MGI:cwg + MP:0002271 + @@ -112713,9 +172013,34 @@ - + The upper conducting airways of the lung; these airways arise from the terminus of the trachea. + BTO:0001340 + CALOHA:TS-1229 + EFO:0000932 + EMAPA:32689 + EV:0100041 + FMA:7409 + GAID:346 + MA:0000436 + MAT:0000133 + MESH:D001980 + MIAA:0000133 + NCIT:C12683 + SCTID:181215002 + VHOG:0000262 + Wikipedia:Bronchus + XAO:0000121 bronchus + + + + The upper conducting airways of the lung; these airways arise from the terminus of the trachea. + ISBN:0-397-51047-0 + MESH:A04.411.125 + MGI:cwg + MP:0002264 + @@ -112735,8 +172060,37 @@ + The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. + BTO:0002375 + CALOHA:TS-2003 + EHDAA:8171 + EHDAA:8183 + EHDAA:8199 + EHDAA:8221 + EMAPA:32697 + FMA:7410 + MA:0000422 + NCIT:C12684 + SCTID:278982001 + VHOG:0000675 + Wikipedia:Bronchiole + In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole. bronchiole + + + + The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. + ISBN:0-397-51047-0 + MGI:cwg + MP:0002267 + + + + + In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole. + https://github.com/obophenotype/uberon/issues/2795 + @@ -112762,9 +172116,25 @@ - + A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls. + BTO:0003223 + EMAPA:36282 + FMA:7411 + MA:0000424 + NCIT:C33754 + SCTID:278981008 + Wikipedia:Terminal_bronchiole terminal bronchiole + + + + A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls. + ISBN:0-397-51047-0 + MGI:cwg + MP:0002268 + PMID:16543587 + @@ -112796,9 +172166,23 @@ - + A bronchiole that is the first segment of the respiratory zone. + BTO:0003222 + EMAPA:35729 + FMA:7412 + MA:0000423 + NCIT:C33465 + SCTID:128517006 + Wikipedia:Respiratory_bronchiole respiratory bronchiole + + + + A bronchiole that is the first segment of the respiratory zone. + ISBN:0123813611 + Wikipedia:Respiratory_bronchiole + @@ -112830,9 +172214,19 @@ - + A portion of adipose tissue that is part of the hypodermis, beneath the dermis. + BTO:0004042 + EMAPA:35829 + FMA:74315 + MA:0000473 subcutaneous adipose tissue + + + + A portion of adipose tissue that is part of the hypodermis, beneath the dermis. + http://orcid.org/0000-0002-6601-2165 + @@ -112846,8 +172240,20 @@ + Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. + CALOHA:TS-2018 + EHDAA2:0004615 + EMAPA:18765 + FMA:74562 + MA:0000013 hemolymphoid system + + + + Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. + http://orcid.org/0000-0002-6601-2165 + @@ -112885,9 +172291,23 @@ - + The dermis, epidermis and hypodermis. + AAO:0000239 + BTO:0000634 + FMA:74657 + TAO:0000368 + VSAO:0000029 + Wikipedia:Integument + ZFA:0000368 + galen:Integument integument + + + + The dermis, epidermis and hypodermis. + Wikipedia:Integument + @@ -112912,8 +172332,20 @@ + Vasculature that is part of a head [Automatically generated definition]. + EFO:0003656 + FMA:74710 + TAO:0001267 + XAO:0004152 + ZFA:0001267 vasculature of head + + + + Vasculature that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -112938,8 +172370,18 @@ + A vasculature that is part of a trunk [Automatically generated definition]. + FMA:74712 + TAO:0005024 + ZFA:0005024 vasculature of trunk + + + + A vasculature that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -112965,9 +172407,21 @@ - + A submucosa that is part of a trachea. + BTO:0002115 + EMAPA:35879 + FMA:7472 + MA:0001860 + NCIT:C49307 + SCTID:4419000 submucosa of trachea + + + + A submucosa that is part of a trachea. + OBOL:automatic + @@ -112999,9 +172453,20 @@ - + Vasculature that is part of the eye region. + FMA:74743 + SCTID:123846009 + TAO:0007057 + ZFA:0007057 vasculature of eye + + + + Vasculature that is part of the eye region. + OBOL:automatic + https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726 + @@ -113039,14 +172504,39 @@ + + + Anatomical system that consists of the muscular and skeletal systems. + AAO:0010546 + CALOHA:TS-1311 + EMAPA:32714 + EV:0100139 + FMA:7482 + GAID:98 + MA:0002418 + MESH:D009141 + NCIT:C12754 + SCTID:278858007 + VHOG:0001275 + VSAO:0000031 + Wikipedia:Musculoskeletal_system + XAO:0000168 musculoskeletal system + + + + Anatomical system that consists of the muscular and skeletal systems. + VSAO:0000031 + VSAO:curator + https://github.com/obophenotype/uberon/issues/77 + @@ -113071,8 +172561,23 @@ + Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]. + EMAPA:36581 + FMA:7496 + MA:0000320 + SCTID:58442004 + TAO:0005155 + Wikipedia:Cartilaginous_joint + ZFA:0005155 cartilaginous joint + + + + Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]. + FMA:FMA + Wikipedia:Cartilaginous_joint + @@ -113104,8 +172609,27 @@ + Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]. + AEO:0000183 + CALOHA:TS-2138 + EHDAA2:0003183 + FMA:7501 + MA:0000322 + NCIT:C32461 + SCTID:113234001 + TAO:0005153 + Wikipedia:Synovial_joint + ZFA:0005153 + galen:SynovialJoint synovial joint + + + + Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]. + FMA:7501 + Wikipedia:Synovial_joint + @@ -113140,8 +172664,24 @@ + The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. + EMAPA:36497 + FMA:7565 + GAID:93 + MA:0000032 + MESH:D035423 + NCIT:C12905 + SCTID:243949006 + Wikipedia:Thoracic_cavity thoracic cavity + + + + The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. + UBERON:cjm + Wikipedia:Thoracic_cavity + @@ -113182,9 +172722,42 @@ - + Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO). + AAO:0010151 + BAMS:SP + BAMS:Spinal + BIRNLEX:1709 + BM:SpC + BTO:0001279 + CALOHA:TS-0953 + DHBA:12890 + DMBA:17651 + EFO:0000110 + EHDAA2:0001255 + EHDAA:2863 + EMAPA:17577 + EV:0100316 + FMA:7647 + GAID:695 + MA:0000216 + MAT:0000183 + MESH:D013116 + MIAA:0000183 + NCIT:C12464 + SCTID:180959008 + TAO:0000075 + VHOG:0000601 + Wikipedia:Spinal_cord + XAO:0000020 + ZFA:0000075 spinal cord + + + + Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO). + BIRNLEX:1709 + @@ -113198,8 +172771,23 @@ + Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]. + AAO:0010169 + EHDAA2:0000243 + EMAPA:17681 + TAO:0001424 + VHOG:0000288 + Wikipedia:Chondrocranium + ZFA:0001424 chondrocranium + + + + Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]. + Wikipedia:Chondrocranium + http://medical-dictionary.thefreedictionary.com/chondrocranium + @@ -113232,8 +172820,32 @@ + The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]. + BAMS:VH + BIRNLEX:2668 + BTO:0005151 + EMAPA:18575 + EMAPA:35794 + FMA:256541 + MA:0001134 + NCIT:C33859 + SCTID:279443000 + TAO:0000702 + VHOG:0001288 + Wikipedia:Anterior_horn_of_spinal_cord + ZFA:0000702 + neuronames:1751 ventral horn of spinal cord + + + + The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]. + GO:0021517 + MP:0005112 + Wikipedia:Anterior_horn_of_spinal_cord + https://sourceforge.net/tracker/?group_id=36855&atid=440764 + @@ -113247,8 +172859,139 @@ + A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ). + BAMS:RET + EMAPA:35188 + FMA:77719 + MA:0003185 + MESH:D012154 + NLX:143558 + SCTID:361552007 + Wikipedia:Reticular_formation + neuronames:1223 reticular formation + + + + A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ). + NeuroNames:1223 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree). + FMA:79646 + GAID:279 + MA:0001273 + MESH:D001659 + NCIT:C12678 + SCTID:361354009 + Wikipedia:Biliary_system + biliary system + + + + + Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree). + Wikipedia:Biliary_system + + + + + + + + + + + + + + + + + + + + + The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]. + EHDAA2:0004560 + EHDAA:3019 + EHDAA:3033 + EHDAA:3921 + EHDAA:3934 + EHDAA:3957 + EHDAA:3971 + FMA:79795 + SCTID:308823000 + TAO:0005130 + Wikipedia:Mesentery#Development + ZFA:0005130 + dorsal mesentery + + + + + The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]. + Wikipedia:Dorsal_mesentery + Wikipedia:Mesentery#Development + ZFIN:curator + @@ -113280,8 +173023,36 @@ + Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. + BAMS:BS + BIRNLEX:1565 + BTO:0000146 + CALOHA:TS-0093 + EFO:0001962 + EMAPA:32678 + EV:0100241 + FMA:79876 + MA:0000169 + MBA:343 + MESH:D001933 + NCIT:C12441 + SCTID:180925009 + TAO:0002156 + VHOG:0001457 + Wikipedia:Brainstem + ZFA:0001707 + 'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions). brainstem + + + + Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. + ISBN:0471888893 + MP:0005277 + Wikipedia:Brainstem + ZFA:0001707 + @@ -113331,9 +173102,26 @@ - + Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]. + BTO:0000060 + CALOHA:TS-0031 + EFO:0001985 + EMAPA:32682 + FMA:7318 + GAID:349 + MA:0000420 + MESH:D011650 + SCTID:361364000 + VHOG:0001445 + Wikipedia:Pulmonary_alveolus alveolus of lung + + + + Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP]. + Wikipedia:Pulmonary_alveolus + @@ -113364,8 +173152,24 @@ + The atrial part of middle layer of the heart, comprised of involuntary muscle. + EFO:0003087 + EMAPA:32746 + FMA:83509 + MA:0000081 + SCTID:191910002 + TAO:0001374 + VHOG:0000602 + ZFA:0001374 myocardium of atrium + + + + The atrial part of middle layer of the heart, comprised of involuntary muscle. + ISBN:0-683-40008-8 + MP:0010493 + @@ -113390,8 +173194,21 @@ + A neural nucleus that is part of the brain. + EMAPA:35185 + FMA:83840 + MA:0000811 + NCIT:C49346 + SCTID:426465002 + ZFA:0005575 nucleus of brain + + + + A neural nucleus that is part of the brain. + http://orcid.org/0000-0002-6601-2165 + @@ -113422,8 +173239,24 @@ + The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue. + BAMS:Scgrey + DHBA:146035048 + EMAPA:35792 + FMA:256580 + MA:0000002 + NCIT:C32696 + NLXANAT:100204 + SCTID:279441003 + neuronames:2619 gray matter of spinal cord + + + + The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue. + MP:0008503 + @@ -113443,8 +173276,26 @@ + The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. + AEO:0000186 + BTO:0001707 + EHDAA2:0000267 + FMA:85006 + NCIT:C25444 + RETIRED_EHDAA2:0003186 + SCTID:361348008 + TAO:0001438 + ZFA:0001438 + galen:BodyCavity + EDITOR_NOTE check the FMA placement here; ncit placement of body cavity here probably not correct coelemic cavity lumen + + + + The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. + BTO:0001707 + @@ -113470,9 +173321,18 @@ - + Any muscle organ that is part of a back [Automatically generated definition]. + EMAPA:35161 + FMA:85216 + MA:0000496 muscle of back + + + + Any muscle organ that is part of a back [Automatically generated definition]. + OBOL:automatic + @@ -113531,8 +173391,41 @@ + A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. + AAO:0000327 + BTO:0001768 + CALOHA:TS-0690 + EHDAA2:0001277 + EHDAA:1241 + EHDAA:6021 + EMAPA:16191 + EV:0100002 + FMA:85521 + GAID:1311 + MAT:0000281 + MESH:D009672 + NCIT:C12463 + SCTID:308820002 + TAO:0000135 + VHOG:0000199 + VSAO:0000032 + Wikipedia:Notochord + XAO:0000055 + ZFA:0000135 + http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg + The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB] notochord + + + + A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. + ISBN:0815318960 + Wikipedia:Notochord + http://tolweb.org/Chordata/2499 + https://github.com/obophenotype/uberon/issues/25 + https://github.com/obophenotype/uberon/issues/271 + @@ -113553,8 +173446,35 @@ + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. + AAO:0010569 + AEO:0001015 + BTO:0001558 + EHDAA2:0003436 + EHDAA:366 + EHDAA:699 + EMAPA:31169 + FMA:85522 + GAID:1306 + MAT:0000068 + MESH:D019170 + MIAA:0000068 + NCIT:C34302 + TAO:0000155 + VHOG:0000191 + Wikipedia:Somite + XAO:0000058 + ZFA:0000155 + When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248] somite + + + + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. + DOI:10.1111/j.1439-0426.2012.01987.x + Wikipedia:Somite + @@ -113583,10 +173503,26 @@ + + Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. + CALOHA:TS-2057 + EHDAA2:0002225 + EMAPA:35329 + FMA:85539 + MA:0002411 + NCIT:C12957 + Wikipedia:Exocrine_gland + WikipediaCategory:Exocrine_system exocrine system + + + + Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. + Wikipedia:Exocrine_gland + @@ -113612,9 +173548,23 @@ - + An arterial trunk which is continuous with the heart and branches into the pulmonary arteries. + EHDAA2:0001576 + EHDAA:9831 + EMAPA:17015 + FMA:8612 + MA:0002033 + NCIT:C116918 + VHOG:0001134 + galen:PulmonaryTrunk pulmonary trunk + + + + An arterial trunk which is continuous with the heart and branches into the pulmonary arteries. + http://orcid.org/0000-0002-6601-2165 + @@ -113640,8 +173590,19 @@ + A lamina propria that is part of a bronchus [Automatically generated definition]. + EMAPA:35194 + FMA:86619 + MA:0001836 + NCIT:C49212 lamina propria of bronchus + + + + A lamina propria that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -113687,8 +173648,33 @@ + A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. + AAO:0010578 + BTO:0001764 + CALOHA:TS-0676 + EHDAA2:0004419 + EMAPA:32737 + FMA:86666 + GAID:1310 + MAT:0000066 + MESH:D009432 + MIAA:0000066 + NCIT:C34222 + SCTID:361462002 + VHOG:0000057 + Wikipedia:Neural_crest + XAO:0000048 + ZFA:0000045 + neuronames:1366 + Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. neural crest + + + + A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. + MP:0009846 + @@ -113713,8 +173699,19 @@ + Set of all muscles in abdomen. + FMA:71294 + FMA:86917 + TAO:0001327 + ZFA:0001327 abdomen musculature + + + + Set of all muscles in abdomen. + OBOL:automatic + @@ -113747,9 +173744,20 @@ - + The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + EFO:0002527 + EMAPA:18605 + FMA:87217 + MA:0002572 + SCTID:181301002 descending thoracic aorta + + + + The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. + MP:0009868 + @@ -113764,8 +173772,76 @@ + Embryonic ectoderm that gives rise to nervous tissue. + AAO:0011074 + BILA:0000039 + CALOHA:TS-1212 + EHDAA2:0001248 + EHDAA:1498 + EHDAA:255 + EMAPA:16073 + EV:0100004 + FMA:87657 + MAT:0000176 + MIAA:0000176 + NCIT:C34228 + TAO:0001120 + VHOG:0000150 + Wikipedia:Neuroectoderm + XAO:0000042 + ZFA:0001120 neurectoderm + + + + Embryonic ectoderm that gives rise to nervous tissue. + Wikipedia:Neuroectoderm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A thoracic vertebra endochondral element that is composed primarily of a bone tissue. + EMAPA:18011 + FMA:9139 + GAID:244 + MA:0000314 + MESH:D013904 + NCIT:C12798 + SCTID:181821009 + Wikipedia:Thoracic_vertebrae + thoracic vertebra + + + + + A thoracic vertebra endochondral element that is composed primarily of a bone tissue. + OBOL:automatic + @@ -113798,9 +173874,26 @@ - + A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart. + AAO:0010409 + EHDAA2:0002202 + FMA:9461 + NCIT:C13164 + TAO:0005057 + VHOG:0000119 + Wikipedia:Epicardium + XAO:0000316 + ZFA:0005057 + galen:Epicardium + EDITOR_NOTE TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer. epicardium + + + + A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -113838,8 +173931,38 @@ + The middle layer of the heart, comprised mainly of striated cardiac muscle fibers. + AAO:0010410 + BSA:0000089 + BTO:0000901 + CALOHA:TS-0440 + EFO:0000819 + EHDAA2:0004150 + EV:0100022 + FMA:9462 + GAID:173 + MA:0000164 + MAT:0000453 + MESH:D009206 + NCIT:C12371 + RETIRED_EHDAA2:0001220 + SCTID:362012001 + TAO:0001319 + VHOG:0000083 + Wikipedia:Myocardium + XAO:0000065 + ZFA:0001319 + galen:Myocardium + EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium myocardium + + + + The middle layer of the heart, comprised mainly of striated cardiac muscle fibers. + ISBN:0-683-40008-8 + MP:0005329 + @@ -113884,8 +174007,26 @@ + The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]. + EFO:0003909 + EHDAA2:0004185 + EMAPA:35428 + EV:0100025 + FMA:9476 + MA:0000094 + MESH:D006329 + SCTID:281489000 + TAO:0005063 + VHOG:0001271 + ZFA:0005063 conducting system of heart + + + + The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]. + GO:0003161 + @@ -113924,9 +174065,29 @@ - + The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]. + BTO:0004358 + EHDAA2:0004184 + EMAPA:35772 + FMA:9477 + GAID:561 + MA:0000097 + MESH:D012849 + NCIT:C33555 + SCTID:277687007 + TAO:0005069 + Wikipedia:Sinoatrial_node + ZFA:0005069 + WP:Heart states: "The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.". Note however that ZFA has SA node. sinoatrial node + + + + The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]. + GO:0003163 + Wikipedia:Sinoatrial_node + @@ -113960,9 +174121,31 @@ - + An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles. + BTO:0005689 + EFO:0000276 + EHDAA2:0004183 + EMAPA:35153 + FMA:9478 + GAID:558 + MA:0000095 + MAT:0000498 + MESH:D001283 + NCIT:C32161 + SCTID:277688002 + TAO:0005070 + VHOG:0001474 + Wikipedia:Atrioventricular_node + ZFA:0005070 atrioventricular node + + + + An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles. + UBERON:cjm + Wikipedia:Atrioventricular_node + @@ -113989,8 +174172,23 @@ + The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. + BTO:0001735 + EMAPA:35718 + FMA:9492 + GAID:560 + MA:0000096 + MESH:D011690 + NCIT:C33430 + Wikipedia:Purkinje_fiber cardiac Purkinje fiber + + + + The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. + GO:0003165 + @@ -114022,8 +174220,21 @@ + Serous membrane which is divided into parietal and visceral serous pericardium. + EMAPA:19030 + FMA:9582 + MA:0002739 + SCTID:243954002 + Wikipedia:Serous_pericardium serous pericardium + + + + Serous membrane which is divided into parietal and visceral serous pericardium. + Wikipedia:Serous_pericardium + http://orcid.org/0000-0002-6601-2165 + @@ -114054,8 +174265,30 @@ + A serous membrane that lines the peritoneal cavity[VHOG,modified]. + AAO:0010814 + BTO:0001472 + CALOHA:TS-2072 + EV:0100087 + FMA:9584 + GAID:18 + MA:0000449 + MESH:D010537 + NCIT:C12770 + TAO:0005120 + VHOG:0001257 + Wikipedia:Peritoneum + XAO:0000139 + ZFA:0005120 + galen:Peritoneum peritoneum + + + + A serous membrane that lines the peritoneal cavity[VHOG,modified]. + VHOG:0001257 + @@ -114082,8 +174315,20 @@ + Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]. + EMAPA:19029 + FMA:9586 + MA:0002738 + SCTID:243953008 + Wikipedia:Fibrous_pericardium fibrous pericardium + + + + Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]. + FMA:9586 + @@ -114114,8 +174359,27 @@ + A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas. + AEO:0000097 + BTO:0000765 + CALOHA:TS-2012 + EHDAA2:0003097 + EMAPA:35327 + FMA:9596 + GAID:34 + MA:0002564 + MESH:D005088 + NCIT:C12712 + SCTID:115976003 + Wikipedia:Exocrine_gland exocrine gland + + + + A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas. + Wikipedia:Exocrine_gland + @@ -114146,8 +174410,27 @@ + Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]. + AEO:0000098 + BTO:0001488 + CALOHA:TS-1300 + EHDAA2:0003098 + EMAPA:35999 + FMA:9602 + GAID:335 + MA:0002563 + MESH:D004702 + NCIT:C12704 + SCTID:40818001 + Wikipedia:Endocrine_gland endocrine gland + + + + Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]. + Wikipedia:Endocrine_gland + @@ -114201,9 +174484,35 @@ - + The soft tissue that fills the cavities of bones. + AAO:0011007 + BTO:0000141 + BTO:0000829 + CALOHA:TS-0087 + EFO:0000868 + EMAPA:32760 + EV:0100046 + FMA:9608 + GAID:1287 + MA:0000134 + MAT:0000084 + MESH:D001853 + MIAA:0000084 + NCIT:C12431 + SCTID:421320006 + VHOG:0001218 + Wikipedia:Bone_marrow + XAO:0000123 + galen:BoneMarrow bone marrow + + + + The soft tissue that fills the cavities of bones. + MGI:cwg + MP:0002397 + @@ -114245,9 +174554,25 @@ - + Any skeletal muscle that is part of the head region. + AAO:0000107 + BTO:0000021 + EFO:0003524 + EHDAA2:0000322 + EMAPA:18172 + FMA:9616 + MA:0000578 + SCTID:244718003 + ZFA:0001652 + defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984) cranial muscle + + + + Any skeletal muscle that is part of the head region. + http://orcid.org/0000-0002-6601-2165 + @@ -114272,9 +174597,20 @@ - + Any muscle that is part of the cervical (neck) region. + FMA:9617 + GAID:149 + MA:0000587 + MESH:D009334 + NCIT:C33163 muscle of neck + + + + Any muscle that is part of the cervical (neck) region. + http://orcid.org/0000-0002-6601-2165 + @@ -114306,9 +174642,24 @@ - + Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis. + BTO:0001261 + EMAPA:35103 + FMA:9620 + GAID:89 + MA:0000520 + MESH:D000009 + NCIT:C32040 + SCTID:361352008 + Wikipedia:Abdominal_muscle muscle of abdomen + + + + Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis. + Wikipedia:Abdominal_muscle + @@ -114322,9 +174673,37 @@ - + Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. + AAO:0000098 + BTO:0000421 + CALOHA:TS-2009 + EFO:0000952 + EMAPA:35251 + FMA:9640 + GAID:100 + MA:0000011 + MAT:0000301 + MESH:D003238 + MIAA:0000301 + NCIT:C12374 + SCTID:361919005 + TAO:0001641 + VSAO:0000017 + XAO:0001017 + ZFA:0001632 + galen:ConnectiveTissue connective tissue + + + + Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000017 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/23 + @@ -114369,8 +174748,30 @@ + Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. + AAO:0000306 + AEO:0000122 + CALOHA:TS-0642 + EHDAA2:0003122 + EMAPA:32715 + FMA:9641 + MA:0002437 + MESH:D009132 + NCIT:C12435 + SCTID:91727004 + Wikipedia:Muscle_tissue + galen:MuscleTissue + Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach. muscle tissue + + + + Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. + GO:0060537 + Wikipedia:Muscle_tissue + https://sourceforge.net/tracker/index.php?func=detail&aid=2801266&group_id=36855&atid=440764 + @@ -114399,11 +174800,146 @@ + - + Anatomical system that is involved in the production of hematopoietic cells. + AAO:0011002 + BTO:0000570 + CALOHA:TS-0449 + EFO:0000798 + EMAPA:35402 + EV:0100045 + FMA:9667 + GAID:1008 + MA:0002434 + MAT:0000022 + MESH:D006413 + MIAA:0000022 + NCIT:C12909 + SCTID:362587009 + TAO:0005023 + VHOG:0001624 + Wikipedia:Haematopoiesis + XAO:0000122 + ZFA:0005023 hematopoietic system + + + + Anatomical system that is involved in the production of hematopoietic cells. + Wikipedia:Haematopoiesis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine. + AAO:0011019 + BTO:0000122 + CALOHA:TS-0075 + EMAPA:35171 + EV:0100091 + FMA:9706 + GAID:280 + MA:0000354 + MESH:D001652 + NCIT:C12376 + SCTID:276157007 + TAO:0001100 + VHOG:0000212 + Wikipedia:Bile_duct + XAO:0000134 + ZFA:0001100 + bile duct + + + + + Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine. + Wikipedia:Bile_duct + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + The triangular flat bone of the nasal septum. + AAO:0000633 + FMA:9710 + MA:0001496 + NCIT:C33888 + SCTID:272678009 + TAO:0000308 + Wikipedia:Vomer + ZFA:0000308 + vomer + + + + + The triangular flat bone of the nasal septum. + ISBN:0-683-40008-8 + MP:0000098 + @@ -114451,8 +174987,24 @@ + The outer serous membrane of the pulmonary pleural. + EMAPA:16776 + FMA:9733 + MA:0002488 + NCIT:C33273 + SCTID:361998003 + VHOG:0001495 + Wikipedia:Parietal_pleura + the part of the pleura external to the visceral pleura. It lines the inner surface of the chest wall, covers the diaphragm, and is reflected over the structures occupying the middle of the thorax parietal pleura + + + + The outer serous membrane of the pulmonary pleural. + UBERON:cjm + Wikipedia:Pulmonary_pleurae + @@ -114506,9 +175058,23 @@ - + The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs. + EHDAA2:0002205 + EMAPA:16777 + FMA:9734 + MA:0002489 + NCIT:C33881 + SCTID:361997008 + VHOG:0001496 visceral pleura + + + + The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs. + UBERON:cjm + Wikipedia:Pulmonary_pleurae + @@ -114551,8 +175117,28 @@ + The fluid-filled cavity that lies between the visceral and parietal pleurae. + BTO:0004422 + EHDAA2:0001475 + EMAPA:16773 + EMAPA:16774 + FMA:9740 + GAID:95 + MA:0000055 + MESH:D035422 + NCIT:C12840 + SCTID:361999006 + VHOG:0000581 + Wikipedia:Pleural_cavity pleural cavity + + + + The fluid-filled cavity that lies between the visceral and parietal pleurae. + Wikipedia:Pleural_cavity + https://github.com/obophenotype/uberon/issues/86 + @@ -114579,11 +175165,32 @@ + - + Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies. + AAO:0011003 + BILA:0000104 + BTO:0005810 + FMA:9825 + GAID:328 + MA:0002711 + MESH:D007107 + NCIT:C12735 + SCTID:362590003 + TAO:0001159 + VHOG:0001247 + Wikipedia:Immune_system + XAO:0003152 + ZFA:0001159 immune system + + + + Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies. + Wikipedia:Immune_system + @@ -114631,8 +175238,19 @@ + A double-walled sac containing the heart and the roots of the great vessels. + FMA:9868 + RETIRED_EHDAA2:0001443 + SCTID:361326002 pericardial sac + + + + A double-walled sac containing the heart and the roots of the great vessels. + Wikipedia:Pericardium + https://github.com/obophenotype/uberon/issues/86 + @@ -114664,9 +175282,36 @@ - + The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium. + AAO:0010817 + BSA:0000090 + BTO:0000717 + CALOHA:TS-0761 + EFO:0000820 + EHDAA:5376 + EV:0100023 + FMA:9869 + GAID:569 + MA:0000099 + MAT:0000454 + MESH:D010496 + NCIT:C13005 + RETIRED_EHDAA2:0001443 + SCTID:181295003 + VHOG:0001280 + Wikipedia:Pericardium + XAO:0004182 + ZFA:0000054 + galen:Pericardium pericardium + + + + The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium. + Wikipedia:Pericardium + http://orcid.org/0000-0002-6601-2165 + @@ -114691,8 +175336,24 @@ + Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac. + EHDAA:3422 + EHDAA:5378 + EMAPA:19031 + FMA:9870 + MA:0000483 + NCIT:C94500 + SCTID:243956000 + VHOG:0000537 + Wikipedia:Parietal_pericardium parietal serous pericardium + + + + Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac. + http://orcid.org/0000-0002-6601-2165 + @@ -114724,8 +175385,20 @@ + Transudate contained in the pericardial cavity.[FMA]. + BTO:0001016 + FMA:9887 + MA:0002530 + Wikipedia:Pericardial_fluid pericardial fluid + + + + Transudate contained in the pericardial cavity.[FMA]. + FMA:9887 + Wikipedia:Pericardial_fluid + @@ -114751,8 +175424,177 @@ + The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]. + AAO:0000033 + BIRNLEX:1123 + BTO:0002507 + CALOHA:TS-2001 + EHDA:10095 + EHDAA2:0000158 + EHDAA:3767 + EMAPA:16984 + FMA:65553 + GAID:706 + MA:0000219 + MESH:D001341 + NCIT:C12673 + SCTID:362481007 + TAO:0001574 + VHOG:0000396 + Wikipedia:Autonomic_nervous_system + ZFA:0001574 + neuronames:2054 autonomic nervous system + + + + The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]. + GO:0048483 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + AAO:0000691 + CALOHA:TS-2352 + EFO:0001371 + EMAPA:32740 + FMA:9914 + MA:0000309 + NCIT:C12933 + SCTID:181817002 + TAO:0001189 + Wikipedia:Vertebra + XAO:0004019 + ZFA:0001189 + galen:Vertebra + vertebra + + + + + The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + GO_REF:0000034 + VSAO:0000184 + http://dx.plos.org/10.1371/journal.pone.0051070 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vertebra that is located in the cervical region of the vertebral column. + EMAPA:17674 + FMA:9915 + GAID:235 + MA:0000311 + MESH:D002574 + NCIT:C12693 + SCTID:181820005 + Wikipedia:Cervical_vertebrae + XAO:0003076 + galen:CervicalVertebra + cervical vertebra + + + + + A vertebra that is located in the cervical region of the vertebral column. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail. + AEO:0000109 + BILA:0000117 + BTO:0001348 + EFO:0000963 + EHDAA:9198 + GAID:1245 + MAT:0000094 + MESH:D013623 + MIAA:0000094 + WBbt:0005741 + Wikipedia:Tail + tail + + + + + An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail. + AEO:0000109 + Wikipedia:Tail + @@ -114784,11 +175626,43 @@ + - + Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. + AEO:0000154 + BILA:0000118 + CALOHA:TS-1299 + CARO:0002001 + EFO:0000807 + EHDAA2:0000836 + EHDAA2_RETIRED:0003154 + EHDAA:6520 + EMAPA:17524 + EV:0100151 + FMA:72979 + HAO:0000421 + MA:0000014 + MAT:0000033 + MESH:D034582 + MIAA:0000033 + NCIT:C12907 + SCTID:361692004 + TADS:0000108 + VHOG:0000403 + Wikipedia:Integumentary_system + XAO:0000176 + galen:Surface integumental system + + + + Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. + CARO:0002001 + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/29 + @@ -114797,8 +175671,20 @@ + The abdominal segment of the torso. + EMAPA:35104 + FMA:259211 + MA:0000021 + SCTID:362875007 + Wikipedia:Lumbar abdominal segment of trunk + + + + The abdominal segment of the torso. + Wikipedia:Lumbar + @@ -114830,8 +175716,44 @@ + Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts. + AAO:0000060 + AEO:0000087 + BTO:0000206 + EFO:0000949 + EHDAA2:0003087 + EMAPA:32730 + EV:0100141 + FMA:37377 + GAID:99 + MA:0000104 + MAT:0000189 + MESH:D002356 + MIAA:0000189 + NCIT:C12373 + NCIT:C32268 + SCTID:309312004 + TAO:0001501 + VHOG:0001207 + VSAO:0000040 + Wikipedia:Cartilage + XAO:0000170 + ZFA:0005622 + galen:Cartilage + Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W] cartilage tissue + + + + Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000040 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/37 + https://sourceforge.net/p/obo/vertebrate-skeletal-anatomy-vsao-term-requests/5 + @@ -114858,8 +175780,89 @@ + A gland that is part of a skin of body [Automatically generated definition]. + EMAPA:35774 + FMA:71878 + MA:0000146 + SCTID:110485007 skin gland + + + + A gland that is part of a skin of body [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the digestive system that contains the liver and the biliary system. + AAO:0011056 + CALOHA:TS-1308 + EFO:0000800 + EHDAA2:0000998 + EHDAA:2189 + EMAPA:16840 + EV:0100088 + MA:0000324 + MAT:0000024 + MIAA:0000024 + NCIT:C43612 + TAO:0000036 + VHOG:0000294 + Wikipedia:Hepatobiliary_system + XAO:0000132 + ZFA:0000036 + hepatobiliary system + + + + + The part of the digestive system that contains the liver and the biliary system. + http://orcid.org/0000-0002-6601-2165 + @@ -114891,8 +175894,29 @@ + An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues. + AAO:0010357 + BTO:0001775 + CALOHA:TS-0715 + EHDAA2:0001325 + EHDAA:2187 + EMAPA:16839 + EMAPA:26942 + FMA:265152 + MA:0000344 + NCIT:C49595 + TAO:0000816 + VHOG:0000187 + XAO:0003201 + ZFA:0000816 oral epithelium + + + + An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues. + https://orcid.org/0000-0002-6601-2165 + @@ -114935,8 +175959,21 @@ + Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]. + EMAPA:19032 + FMA:84882 + MA:0000484 + SCTID:243955001 + VHOG:0000538 + Wikipedia:Visceral_pericardium visceral serous pericardium + + + + Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]. + Wikipedia:Visceral_pericardium + @@ -114962,8 +175999,19 @@ + A blood vessel that is part of a choroid [Automatically generated definition]. + EMAPA:17828 + FMA:76550 + MA:0001237 + cannot find singular in FMA, using Set class choroidal blood vessel + + + + A blood vessel that is part of a choroid [Automatically generated definition]. + OBOL:automatic + @@ -114972,8 +176020,24 @@ + The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries. + EHDAA2:0000882 + EHDAA:4340 + EMAPA:17616 + MA:0001985 + SCTID:360401001 + TAO:0001061 + VHOG:0000225 + XAO:0004165 + ZFA:0001061 intersomitic artery + + + + The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries. + MP:0010662 + @@ -114998,8 +176062,65 @@ + Arteries that supply the spinal cord. + EHDAA2:0001890 + EHDAA:4355 + EMAPA:18241 + MA:0002043 + NCIT:C33587 + SCTID:244228006 + TAO:0000682 + Wikipedia:Spinal_artery + ZFA:0000682 spinal artery + + + + Arteries that supply the spinal cord. + Wikipedia:Spinal_artery + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine. + BTO:0000644 + FMA:62974 + GAID:1162 + MA:0002515 + MESH:D007419 + NCIT:C32875 + Wikipedia:Succus_entericus + intestine secretion + + + + + Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine. + Wikipedia:Succus_entericus + @@ -115024,8 +176145,21 @@ + A mucosa that is part of a esophagus [Automatically generated definition]. + BTO:0002859 + EMAPA:26981 + FMA:62996 + MA:0002680 + NCIT:C32538 + SCTID:362127004 esophagus mucosa + + + + A mucosa that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -115046,8 +176180,29 @@ + Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts. + CALOHA:TS-2011 + EMAPA:35179 + FMA:224804 + MA:0002780 + MESH:D001842 + NCIT:C13076 + VSAO:0000047 + Wikipedia:Bone_tissue + XAO:0004040 + ZFA:0005621 + galen:BoneTissue bone tissue + + + + Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000047 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -115085,9 +176240,53 @@ - + An epithelium that is part of a iris [Automatically generated definition]. + EMAPA:35447 + FMA:58517 + MA:0002826 iris epithelium + + + + An epithelium that is part of a iris [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + The supporting bundles of muscular fibers lining the walls of the ventricles of the heart. + EMAPA:18626 + FMA:7269 + MA:0002831 + SCTID:118755002 + Wikipedia:Trabeculae_carneae + trabecula carnea + + + + + The supporting bundles of muscular fibers lining the walls of the ventricles of the heart. + MGI:monikat + MP:0004067 + @@ -115125,8 +176324,28 @@ + Replacement bone that forms within cartilage. + AAO:0010776 + AEO:0000083 + BTO:0002157 + EHDAA2:0003083 + FMA:24321 + TAO:0001591 + VSAO:0000145 + XAO:0004018 + ZFA:0001591 endochondral bone + + + + Replacement bone that forms within cartilage. + GO:0001958 + GO_REF:0000034 + VSAO:0000145 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/54 + @@ -115146,8 +176365,63 @@ + Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. + EMAPA:36615 + TAO:0001644 + Wikipedia:Intramembranous_ossification + ZFA:0001635 intramembranous bone + + + + Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. + GO:0001957 + Wikipedia:Intramembranous_ossification + https://github.com/obophenotype/uberon/issues/267 + + + + + + + + + + + + + + + + + + + + + + + + + + + The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof. + FMA:52801 + MA:0002840 + MESH:D019291 + MFMO:0000044 + NCIT:C12493 + SCTID:181890004 + Wikipedia:Base_of_skull + The skull base is formed from a series of cartilages either side of, and rostral to, the notochord, whose tip lies just caudal to the pituitary gland. It is closely associated with the sensory capsules, which partially or completely sur- round the olfactory epithelium, the eye, and the inner ear[PMID:11523816] + basicranium + + + + + The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof. + Wikipedia:Base_of_skull + @@ -115178,8 +176452,22 @@ + Connective tissue composed of elastic fibers. + FMA:20113 + GAID:926 + MA:0002853 + MESH:D004547 + NCIT:C32495 + SCTID:27197004 + Wikipedia:Elastic_fiber elastic tissue + + + + Connective tissue composed of elastic fibers. + http://orcid.org/0000-0002-6601-2165 + @@ -115205,8 +176493,25 @@ + The middle layer of an artery or vein. [WP,unvetted]. + BTO:0002011 + EMAPA:36298 + FMA:55590 + GAID:170 + MA:0002855 + MESH:D017540 + NCIT:C33821 + SCTID:61695000 + Wikipedia:Tunica_media + May be composed of smooth muscle and elastic tissue tunica media + + + + The middle layer of an artery or vein. [WP,unvetted]. + Wikipedia:Tunica_media + @@ -115232,8 +176537,27 @@ + The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]. + BTO:0002012 + EMAPA:36297 + FMA:55589 + GAID:523 + MA:0002861 + MESH:D017539 + NCIT:C33820 + SCTID:8361002 + SCTID:87483006 + Wikipedia:Tunica_intima tunica intima + + + + The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]. + ISBN:0073040584 + NCIT:C33820 + Wikipedia:Tunica_intima + @@ -115259,8 +176583,34 @@ + An organ that functions as a secretory or excretory organ. + AAO:0000212 + AEO:0000096 + BTO:0000522 + EFO:0000797 + EHDAA2:0003096 + EHDAA:2161 + EMAPA:18425 + FMA:7146 + FMA:86294 + HAO:0000375 + MA:0003038 + MAT:0000021 + MIAA:0000021 + NCIT:C13319 + SCTID:134358001 + Wikipedia:Gland + WikipediaCategory:Glands + galen:Gland gland + + + + An organ that functions as a secretory or excretory organ. + MGI:csmith + MP:0002163 + @@ -115274,8 +176624,56 @@ + In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]. + BTO:0004593 + FMA:296704 + MAT:0000067 + MIAA:0000067 + VHOG:0000243 + Wikipedia:Epiblast epiblast (generic) + + + + In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]. + Wikipedia:Epiblast + ZFIN:curator + + + + + + + + + + + + + + + The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node. + AAO:0011104 + BTO:0001445 + EFO:0002748 + EHDAA2:0001976 + EHDAA:1595 + EMAPA:16580 + MAT:0000070 + MIAA:0000070 + TAO:0000077 + VHOG:0000201 + XAO:0000107 + ZFA:0000077 + post-anal tail bud + + + + + The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node. + BTO:0001445 + @@ -115295,8 +176693,23 @@ + Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt]. + BTO:0001237 + EFO:0000939 + HAO:0000933 + MAT:0000163 + MIAA:0000163 + TGMA:0000540 + Wikipedia:Sensillum arthropod sensillum + + + + Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt]. + FBbt:00007152 + Wikipedia:Sensillum + @@ -115330,8 +176743,34 @@ + One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches. + AAO:0010359 + BTO:0001785 + EFO:0000959 + EHDAA:571 + EMAPA:16117 + FMA:293015 + GAID:1292 + MAT:0000242 + MESH:D001934 + MIAA:0000242 + NCIT:C34249 + SCTID:308766004 + TAO:0001306 + VHOG:0000155 + Wikipedia:Pharyngeal_arch + XAO:0000096 + ZFA:0001306 pharyngeal arch + + + + One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches. + PMID:16313389 + ZFA:yb + http://orcid.org/0000-0002-6601-2165 + @@ -115351,8 +176790,24 @@ + Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. + AAO:0010466 + EFO:0001650 + MAT:0000369 + MIAA:0000369 + XAO:0000305 cranial placode + + + + Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. + http://www.ncbi.nlm.nih.gov/books/NBK53175/ + https://github.com/obophenotype/uberon/issues/135 + https://github.com/seger/aao/issues/4 + https://orcid.org/0000-0002-6601-2165 + https://sourceforge.net/p/obo/xenopus-anatomy-xao-term-requests/11/ + @@ -115366,8 +176821,73 @@ + Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina. + BIRNLEX:1011 + FMA:67552 + MA:0002447 + NCIT:C34007 + galen:Cavity anatomical cavity + + + + Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina. + FMA:67552 + + + + + + + + + BIRNLEX:1019 + FMA:12237 + SCTID:362606005 + organ cavity + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube. + BIRNLEX:1029 + FMA:75007 + lumen of central nervous system + + + + + The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube. + https://orcid.org/0000-0002-6601-2165 + @@ -115399,8 +176919,19 @@ + Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. + BIRNLEX:1167 + FMA:55676 + NCIT:C13031 + SCTID:384763002 regional part of brain + + + + Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. + BIRNLEX:1167 + @@ -115431,9 +176962,21 @@ - + A spinal cord segment that adjacent_to a cervical region. + BIRNLEX:1499 + FMA:71166 + MA:0003081 + NCIT:C12892 + SCTID:180960003 + neuronames:1654 cervical spinal cord + + + + A spinal cord segment that adjacent_to a cervical region. + OBOL:automatic + @@ -115464,8 +177007,28 @@ + A nucleus of brain that is part of a trigeminal nuclear complex. + BM:V + BTO:0001074 + CALOHA:TS-2077 + EMAPA:35883 + EV:0100271 + FMA:71247 + GAID:604 + MA:0001028 + MESH:D014278 + NCIT:C12807 + SCTID:280164007 + VHOG:0001353 + http://uri.neuinfo.org/nif/nifstd/nifext_11 trigeminal nucleus + + + + A nucleus of brain that is part of a trigeminal nuclear complex. + OBOL:automatic + @@ -115504,9 +177067,22 @@ - + Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133). + BAMS:PTg + BIRNLEX:923 + DHBA:12416 + FMA:71108 + HBA:9135 + SCTID:362401009 + Wikipedia:Pontine_tegmentum pontine tegmentum + + + + Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133). + BIRNLEX:923 + @@ -115520,8 +177096,19 @@ + A wall, dividing a cavity or structure into smaller ones[WP]. + AAO:0011127 + FMA:86461 + Wikipedia:Septum + general anatomical term in FMA septum + + + + A wall, dividing a cavity or structure into smaller ones[WP]. + Wikipedia:Septum + @@ -115546,9 +177133,22 @@ - + The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]. + BIRNLEX:966 + FMA:71167 + MA:0003082 + NCIT:C12894 + SCTID:278750009 + Wikipedia:Thoracic_spinal_cord + neuronames:1718 thoracic spinal cord + + + + The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]. + Wikipedia:Thoracic_spinal_cord + @@ -115596,8 +177196,26 @@ + The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. + AAO:0011064 + DMBA:16810 + EHDAA2:0004395 + EHDAA:5789 + EMAPA:32857 + NCIT:C93172 + TAO:0000042 + VHOG:0000649 + XAO:0000016 + ZFA:0000042 + neuronames:2076 midbrain-hindbrain boundary + + + + The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. + GO:0021555 + @@ -115607,8 +177225,25 @@ + The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm. + EHDAA2:0001846 + EHDAA:6538 + FMA:295662 + NCIT:C34247 + TAO:0001185 + VHOG:0001680 + XAO:0000029 + ZFA:0001185 periderm + + + + The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm. + ISBN:9780878932504 + PMID:25133425 + PMID:35582825 + @@ -115629,8 +177264,20 @@ + The portion of neural plate anterior to the mid-hindbrain junction. + AAO:0011084 + TAO:0007016 + VHOG:0001200 + XAO:0000045 + ZFA:0007016 pre-chordal neural plate + + + + The portion of neural plate anterior to the mid-hindbrain junction. + XB:curator + @@ -115650,8 +177297,19 @@ + The portion of neural plate posterior to the mid-hindbrain junction. + TAO:0007017 + VHOG:0001201 + XAO:0000046 + ZFA:0007017 chordal neural plate + + + + The portion of neural plate posterior to the mid-hindbrain junction. + XB:curator + @@ -115692,8 +177350,23 @@ + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. + AAO:0011086 + EFO:0001982 + EMAPA:16189 + EMAPA:16752 + TAO:0000279 + VHOG:0000559 + XAO:0000057 + ZFA:0000279 presomitic mesoderm + + + + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. + ZFIN:curator + @@ -115713,8 +177386,25 @@ + Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. + AAO:0011006 + EFO:0003489 + EHDAA:207 + NCIT:C34113 + TAO:0000094 + TE:E5.11.2.0.0.0.4 + VHOG:0000085 + Wikipedia:Blood_island_of_umbilical_vesicle + XAO:0000067 + ZFA:0000094 blood island + + + + Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. + Wikipedia:Blood_island_of_umbilical_vesicle + @@ -115734,8 +177424,25 @@ + A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue. + AAO:0011085 + EHDAA2:0001493 + EHDAA:181 + FMA:295532 + TAO:0000060 + VHOG:0000086 + Wikipedia:Prechordal_plate + XAO:0000079 + ZFA:0000060 prechordal plate + + + + A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue. + ISBN:0838580343 + MP:0004387 + @@ -115773,8 +177480,27 @@ + The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. + AAO:0010575 + EMAPA:16056 + EMAPA:16178 + FMA:293147 + NCIT:C34193 + SCTID:361476001 + TAO:0001206 + VHOG:0000087 + Wikipedia:Intermediate_mesoderm + XAO:0000085 + ZFA:0001206 intermediate mesoderm + + + + The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. + GOC:curators + Wikipedia:Intermediate_mesoderm + @@ -115788,8 +177514,20 @@ + Lateral neurogenic placodes positioned dorsal of the epibranchial placodes. + TAO:0001310 + VHOG:0000103 + XAO:0000187 + ZFA:0001310 + The only remaining dorsolateral placode in land vertebrates is the otic/octaval placode dorsolateral placode + + + + Lateral neurogenic placodes positioned dorsal of the epibranchial placodes. + ZFIN:curator + @@ -115815,8 +177553,23 @@ + The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. + AAO:0011017 + EFO:0003647 + TAO:0001204 + VHOG:0000107 + Wikipedia:Chordamesoderm + XAO:0000205 + ZFA:0001204 axial mesoderm + + + + The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. + GO:0048318 + Wikipedia:Chordamesoderm + @@ -115830,8 +177583,23 @@ + A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion. + EFO:0003433 + EHDAA2:0004209 + TAO:0000162 + VHOG:0000109 + XAO:0000225 + ZFA:0000162 trigeminal placode complex + + + + A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion. + PMID:22512454 + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/693 + @@ -115872,8 +177640,23 @@ + Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles. + AAO:0011038 + EFO:0003541 + EHDAA2:0004431 + TAO:0000570 + XAO:0000227 + XAO:0004090 + ZFA:0000570 eye primordium + + + + Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles. + GO:0046619 + ZFA:0000570 + @@ -115900,8 +177683,26 @@ + Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]. + BTO:0005351 + EHDAA2:0001303 + EHDAA:2912 + EMAPA:16674 + NCIT:C34233 + SCTID:308789007 + TAO:0001202 + VHOG:0000167 + ZFA:0001202 optic cup + + + + Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]. + MP:0004269 + Wikipedia:Optic_cup_(embryology) + ZFA:0001202 + @@ -115941,8 +177742,28 @@ + A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]. + AAO:0011055 + EFO:0003494 + EHDAA2:0000982 + EHDAA:2908 + EMAPA:16672 + FMA:296767 + NCIT:C34202 + TAO:0000122 + VHOG:0000166 + Wikipedia:Lens_placode + XAO:0000240 + ZFA:0000122 lens placode + + + + A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]. + Wikipedia:Lens_placode + ZFIN:curator + @@ -115970,8 +177791,34 @@ + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. + AAO:0011072 + BTO:0001765 + DHBA:10153 + DMBA:15565 + EHDAA:346 + EHDAA:902 + EMAPA:35593 + FMA:293879 + NCIT:C34225 + RETIRED_EHDAA2:0001252 + TAO:0000132 + VHOG:0000068 + Wikipedia:Neural_plate + XAO:0000249 + ZFA:0000132 + neuronames:1362 neural plate + + + + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. + ISBN:0815318960 + OMD:neural+plate + Wikipedia:Neural_plate + ZFIN:curator + @@ -115991,6 +177838,11 @@ + AAO:0011082 + TAO:0007037 + VHOG:0001383 + XAO:0000250 + ZFA:0007037 posterior neural tube @@ -116020,8 +177872,28 @@ + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. + AAO:0010568 + EFO:0003515 + EMAPA:16183 + EMAPA:16751 + FMA:293145 + NCIT:C34244 + SCTID:361475002 + TAO:0000255 + VHOG:0000114 + Wikipedia:Paraxial_mesoderm + XAO:0000259 + ZFA:0000255 paraxial mesoderm + + + + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. + GO:0048339 + https://github.com/obophenotype/uberon/issues/30 + @@ -116047,8 +177919,22 @@ + Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia. + AAO:0011036 + EFO:0003455 + FMA:293968 + TAO:0001294 + VHOG:0000117 + XAO:0000284 + ZFA:0001294 epibranchial placode + + + + Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia. + VHOG:0000117 + @@ -116068,6 +177954,11 @@ + AAO:0011012 + TAO:0007038 + VHOG:0001384 + XAO:0000307 + ZFA:0007038 anterior neural tube @@ -116098,8 +177989,28 @@ + Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. + AAO:0010574 + EHDAA2:0000919 + EHDAA:379 + EMAPA:16179 + FMA:293149 + NCIT:C34199 + SCTID:361477005 + TAO:0000121 + VHOG:0000118 + Wikipedia:Lateral_plate_mesoderm + XAO:0000311 + ZFA:0000121 lateral plate mesoderm + + + + Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. + MP:0010117 + Wikipedia:Lateral_plate_mesoderm + @@ -116119,8 +178030,32 @@ + A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells. + AAO:0011067 + AEO:0001018 + BTO:0000742 + EHDAA2_RETIRED:0003431 + EHDAA:1721 + EHDAA:1727 + EHDAA:1733 + EHDAA:1739 + EMAPA:32841 + FMA:295658 + NCIT:C34214 + SCTID:344535001 + TAO:0001056 + VHOG:0001244 + Wikipedia:Myotome + XAO:0000315 + ZFA:0001056 myotome + + + + A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells. + AEO:0001018 + @@ -116142,8 +178077,24 @@ + Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]. + AAO:0010582 + EFO:0003605 + EHDAA2:0001901 + TAO:0001024 + VHOG:0000062 + Wikipedia:Trunk_neural_crest + XAO:0000319 + ZFA:0001024 trunk neural crest + + + + Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]. + ISBN:0815318960 + Wikipedia:Trunk_neural_crest + @@ -116175,8 +178126,73 @@ + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. + AAO:0011044 + BTO:0001887 + NCIT:C34276 + TAO:0000028 + XAO:0000336 + ZFA:0000028 heart primordium + + + + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Extension of the dorsal aorta in the tail. + AAO:0011023 + EFO:0003472 + TAO:0000011 + VHOG:0000123 + Wikipedia:Caudal_artery + XAO:0000364 + ZFA:0000011 + caudal artery + + + + + Extension of the dorsal aorta in the tail. + Wikipedia:Caudal_artery + ZFIN:curator + @@ -116197,8 +178213,28 @@ + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. + AAO:0010571 + AEO:0000212 + EHDAA2:0003439 + EMAPA:31159 + FMA:295652 + NCIT:C34287 + TAO:0001080 + VHOG:0000680 + Wikipedia:Sclerotome + XAO:0000397 + ZFA:0001080 sclerotome + + + + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. + Wikipedia:Sclerotome + XB:curator + https://github.com/obophenotype/uberon/issues/316 + @@ -116220,8 +178256,24 @@ + Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage. + AAO:0010580 + EFO:0003645 + EHDAA2:0004420 + EMAPA:16091 + TAO:0001194 + VHOG:0000063 + Wikipedia:Cranial_neural_crest + XAO:0001001 + ZFA:0001194 cranial neural crest + + + + Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage. + MGI:anna + @@ -116229,8 +178281,25 @@ + Gonochoristic organism that can produce female gametes. + AAO:0010030 + BILA:0000028 + CARO:0000028 + FMA:67812 + HAO:0000028 + SCTID:362608006 + TAO:0000303 + TGMA:0001839 + XAO:0003005 + ZFA:0000303 female organism + + + + Gonochoristic organism that can produce female gametes. + CARO:0000028 + @@ -116244,8 +178313,25 @@ + Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. + AAO:0010337 + AEO_RETIRED:0000010 + EHDAA2_RETIRED:0003010 + TAO:0000292 + VSAO:0000001 + Wikipedia:Surface_structure + XAO:0003028 + ZFA:0000292 + galen:SurfaceRegion surface structure + + + + Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/24 + @@ -116253,8 +178339,27 @@ + Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types. + AAO:0010015 + AEO:0000024 + BILA:0000024 + CARO:0000024 + EHDAA2:0003024 + HAO:0000024 + TADS:0000598 + TAO:0000496 + TGMA:0001837 + VHOG:0001723 + XAO:0003041 + ZFA:0000496 compound organ + + + + Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types. + CARO:0000024 + @@ -116291,8 +178396,63 @@ + Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme. + AAO:0010427 + AEO:0000145 + BTO:0001393 + CALOHA:TS-0620 + EHDAA2:0003145 + EV:0100007 + NCIT:C13301 + TAO:0000393 + VHOG:0000170 + Wikipedia:Mesenchyme + XAO:0003046 + ZFA:0000393 mesenchyme + + + + Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme. + https://archive.org/details/invertebratesnde00brus/page/n240/mode/2up + https://en.wikipedia.org/wiki/Mesenchyme + https://github.com/obophenotype/uberon/issues/1641 + + + + + + + + + + + + + + + + + + + + + Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ. + AAO:0010206 + EFO:0003525 + NCIT:C98765 + TAO:0000351 + XAO:0003172 + ZFA:0000351 + olfactory region + + + + + Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ. + TAO:0000351 + @@ -116312,8 +178472,22 @@ + Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]. + AAO:0010154 + TAO:0000863 + VHOG:0001665 + Wikipedia:Skull_roof + XAO:0003169 + ZFA:0000863 dermatocranium + + + + Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]. + Wikipedia:Skull_roof + ZFA:0000863 + @@ -116321,8 +178495,25 @@ + Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus. + AAO:0010366 + EHDAA2:0000086 + EHDAA:1663 + EMAPA:16760 + FMA:293035 + SCTID:308770007 + TAO:0001599 + VHOG:0000299 + XAO:0000449 + ZFA:0001607 pharyngeal arch 4 + + + + Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus. + MP:0006340 + @@ -116330,8 +178521,24 @@ + The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles. + AAO:0010368 + EHDAA2:0004075 + EMAPA:32766 + FMA:293047 + SCTID:308772004 + TAO:0001601 + VHOG:0001205 + XAO:0000453 + ZFA:0001609 pharyngeal arch 6 + + + + The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles. + MP:0006347 + @@ -116362,8 +178569,24 @@ + The vessels formed within the first pair of branchial arches in embryogenesis. + AAO:0010415 + EHDAA2:0000007 + EMAPA:16202 + EMAPA:16685 + SCTID:308774003 + TAO:0005005 + VHOG:0000149 + XAO:0000342 + ZFA:0005005 pharyngeal arch artery 1 + + + + The vessels formed within the first pair of branchial arches in embryogenesis. + MP:0010355 + @@ -116388,8 +178611,24 @@ + The vessels formed within the fourth pair of branchial arches in embryogenesis. + AAO:0010420 + EHDAA2:0000087 + EMAPA:17004 + SCTID:308777005 + TAO:0005008 + Wikipedia:Aortic_arches#Arch_4 + XAO:0000355 + ZFA:0005008 + proximal right subclavian pharyngeal arch artery 4 + + + + The vessels formed within the fourth pair of branchial arches in embryogenesis. + MP:0006354 + @@ -116414,8 +178653,24 @@ + The vessels formed within the sixth pair of branchial arches in embryogenesis. + AAO:0010422 + EHDAA2:0000102 + EMAPA:17005 + SCTID:308779008 + TAO:0005016 + VHOG:0000144 + Wikipedia:Aortic_arches#Arch_6 + XAO:0000353 + ZFA:0005016 pharyngeal arch artery 6 + + + + The vessels formed within the sixth pair of branchial arches in embryogenesis. + MP:0006355 + @@ -116453,9 +178708,35 @@ - + The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]. + AAO:0010140 + BTO:0001388 + CALOHA:TS-1060 + EFO:0000935 + EHDAA2:0002066 + EHDAA:3078 + EMAPA:16853 + EV:0100040 + FMA:7394 + GAID:361 + MA:0000441 + MAT:0000137 + MESH:D014132 + MIAA:0000137 + NCIT:C12428 + SCTID:181213009 + VHOG:0000371 + Wikipedia:Vertebrate_trachea + XAO:0000118 trachea + + + + The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]. + GO:0060438 + Wikipedia:Vertebrate_trachea + @@ -116463,9 +178744,26 @@ - + Upper portion of the skull that excludes the mandible (when present in the organism). + BTO:0001328 + EFO:0000831 + EHDAA:6029 + FMA:71325 + MA:0000316 + MAT:0000340 + MIAA:0000340 + SCTID:181889008 + VHOG:0000334 + Wikipedia:Cranium_(anatomy) cranium + + + + Upper portion of the skull that excludes the mandible (when present in the organism). + Wikipedia:Cranium_(anatomy) + http://orcid.org/0000-0002-6601-2165 + @@ -116504,8 +178802,29 @@ + Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]. + BTO:0001295 + CALOHA:TS-2344 + EHDAA2:0000325 + EMAPA:17680 + FMA:46565 + GAID:82 + MESH:D012886 + NCIT:C12789 + SCTID:110530005 + Wikipedia:Skull + WikipediaCategory:Skull + galen:Skull skull + + + + Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]. + PMID:11523816 + Wikipedia:Skull + http://sourceforge.net/tracker/?func=detail&aid=2962656&group_id=76834&atid=1205376 + @@ -116531,8 +178850,21 @@ + An organ involved in reproduction. + MA:0001752 + MESH:D005835 + NCIT:C25177 + SCTID:128181006 + TGMA:0000591 + WBbt:0008422 reproductive organ + + + + An organ involved in reproduction. + UBERON:xp + @@ -116557,8 +178889,17 @@ + A female organ involved in reproduction. + EMAPA:28540 + MA:0000544 female reproductive organ + + + + A female organ involved in reproduction. + UBERON:xp + @@ -116566,8 +178907,19 @@ + Organ part that has the form of a hollow cavity[WP]. + EFO:0002513 + FMA:82493 + NCIT:C12986 + Wikipedia:Alveolus alveolus + + + + Organ part that has the form of a hollow cavity[WP]. + Wikipedia:Alveolus + @@ -116592,8 +178944,51 @@ + Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]. ovary septum + + + + Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]. + GO:0080126 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a upper jaw [Automatically generated definition]. + EHDAA2:0002119 + EHDAA:8027 + EMAPA:18971 + epithelium of upper jaw + + + + + An epithelium that is part of a upper jaw [Automatically generated definition]. + OBOL:automatic + @@ -116618,8 +179013,19 @@ + An epithelium that is part of a lower jaw [Automatically generated definition]. + EHDAA2:0001019 + EHDAA:7999 + EMAPA:35516 + VHOG:0000802 epithelium of lower jaw + + + + An epithelium that is part of a lower jaw [Automatically generated definition]. + OBOL:automatic + @@ -116650,8 +179056,19 @@ + The portion of the yolk sac that is derived from endoderm and lines the yolk sac. + EHDAA2:0002215 + EHDAA:166 + EMAPA:16086 + VHOG:0000626 yolk sac endoderm + + + + The portion of the yolk sac that is derived from endoderm and lines the yolk sac. + UBERON:cjm + @@ -116676,8 +179093,89 @@ + An endoderm that is part of a foregut [Automatically generated definition]. + EHDAA2:0004568 + EHDAA:524 endoderm of foregut + + + + An endoderm that is part of a foregut [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm that is part of a midgut [Automatically generated definition]. + EHDAA:987 + EMAPA:16257 + RETIRED_EHDAA2:0001194 + VHOG:0001080 + endoderm of midgut + + + + + An endoderm that is part of a midgut [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm that is part of a hindgut [Automatically generated definition]. + EHDAA:979 + RETIRED_EHDAA2:0000781 + endoderm of hindgut + + + + + An endoderm that is part of a hindgut [Automatically generated definition]. + OBOL:automatic + @@ -116703,8 +179201,72 @@ + A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]. + EHDAA2:0000486 + EHDAA:2923 + EMAPA:17844 skeletal muscle tissue of eye + + + + A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones. + AAO:0000622 + EHDAA2:0002128 + EHDAA:8041 + EMAPA:17927 + FMA:54397 + MA:0001908 + VHOG:0000429 + XAO:0003087 + skeleton of upper jaw + + + + + A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones. + http://orcid.org/0000-0002-6601-2165 + @@ -116748,8 +179310,25 @@ + A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage. + AAO:0000274 + EHDAA2:0004606 + EHDAA:8005 + EMAPA:17910 + FMA:54398 + MA:0001906 + TAO:0001273 + VHOG:0000428 + XAO:0003084 + ZFA:0001273 skeleton of lower jaw + + + + A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage. + http://orcid.org/0000-0002-6601-2165 + @@ -116770,8 +179349,171 @@ + An endothelium that is part of a trachea. + EHDAA:3082 + RETIRED_EHDAA2:0002068 endothelium of trachea + + + + An endothelium that is part of a trachea. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. + EHDAA2:0001922 + EHDAA:2999 + EMAPA:17024 + MA:0001617 + SCTID:261623000 + VHOG:0000358 + mesentery of stomach + + + + + The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. + http://medical-dictionary.thefreedictionary.com/mesogastrium + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery that surrounds the heart. + EHDAA:432 + EMAPA:16212 + RETIRED_EHDAA2:0000739 + VHOG:0000353 + mesentery of heart + + + + + A mesentery that surrounds the heart. + MA:th + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a esophagus [Automatically generated definition]. + EHDAA2:0001288 + EHDAA:2943 + EMAPA:16836 + MA:0001569 + VHOG:0000415 + mesentery of oesophagus + + + + + A mesentery that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a midgut [Automatically generated definition]. + EHDAA2:0001202 + EHDAA:3031 + EMAPA:16721 + EMAPA:17039 + EMAPA:17197 + VHOG:0000413 + mesentery of midgut + + + + + A mesentery that is part of a midgut [Automatically generated definition]. + OBOL:automatic + @@ -116796,8 +179538,19 @@ + A gland that is part of a foregut [Automatically generated definition]. + EHDAA2:0000567 + EHDAA:950 + EMAPA:16557 + VHOG:0000650 gland of foregut + + + + A gland that is part of a foregut [Automatically generated definition]. + OBOL:automatic + @@ -116823,8 +179576,19 @@ + Racemose mucous glands beneath the mucous membrane of the pharynx. + BTO:0004849 + EHDAA2:0001461 + EHDAA:2967 + FMA:55075 pharyngeal gland + + + + Racemose mucous glands beneath the mucous membrane of the pharynx. + http://www.biology-online.org/dictionary/ + @@ -116849,8 +179613,19 @@ + A gland that is part of a integumental system [Automatically generated definition]. + EHDAA2:0000837 + EMAPA:17758 + MA:0000144 + VHOG:0000654 gland of integumental system + + + + A gland that is part of a integumental system [Automatically generated definition]. + OBOL:automatic + @@ -116884,8 +179659,17 @@ + A blood island that is part of a mesoderm. + EHDAA2:0003241 + EHDAA:170 mesoderm blood island + + + + A blood island that is part of a mesoderm. + OBOL:automatic + @@ -116917,8 +179701,19 @@ + Mesenchyme that is part of a developing camera-type eye. + EHDAA2:0000485 + EHDAA:2910 + EMAPA:16673 + VHOG:0001084 eye mesenchyme + + + + Mesenchyme that is part of a developing camera-type eye. + OBOL:automatic + @@ -116943,9 +179738,18 @@ - + Mesenchyme that is part of a developing ovary [Automatically generated definition]. + EHDAA2:0001362 + EHDAA:8128 + VHOG:0001441 mesenchyme of ovary + + + + Mesenchyme that is part of a developing ovary [Automatically generated definition]. + OBOL:automatic + @@ -116970,8 +179774,66 @@ + The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme. + EHDAA2:0002216 + EHDAA:168 + EHDAA:205 + EMAPA:16087 + EMAPA:16267 + VHOG:0000503 + VHOG:0000617 mesenchyme of yolk sac + + + + The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme. + UBERON:cjm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a developing upper jaw [Automatically generated definition]. + EHDAA2:0002124 + EHDAA:8031 + EMAPA:17929 + VHOG:0001099 + mesenchyme of upper jaw + + + + + Mesenchyme that is part of a developing upper jaw [Automatically generated definition]. + OBOL:automatic + @@ -117002,8 +179864,280 @@ + Mesenchyme that is part of a developing lower jaw [Automatically generated definition]. + EHDAA2:0001024 + EHDAA:8003 + EMAPA:17916 + VHOG:0001069 mesenchyme of lower jaw + + + + Mesenchyme that is part of a developing lower jaw [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of an anal canal [Automatically generated definition]. + EMAPA:27217 + EMAPA:27227 + EMAPA:27535 + FMA:85399 + SCTID:7892006 + submucosa of anal canal + + + + + A submucosa that is part of an anal canal [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + The submucous layer of the wall of the rectum. + BTO:0002114 + EMAPA:27083 + FMA:15034 + SCTID:71683001 + submucosa of rectum + + + + + The submucous layer of the wall of the rectum. + BTO:0002114 + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a colon [Automatically generated definition]. + EMAPA:27379 + FMA:14985 + MA:0003200 + SCTID:61647009 + submucosa of colon + + + + + A submucosa that is part of a colon [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a duodenum [Automatically generated definition]. + EMAPA:27027 + EMAPA:27097 + EMAPA:27239 + FMA:14943 + MA:0003213 + SCTID:76519004 + submucosa of duodenum + + + + + A submucosa that is part of a duodenum [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a rectum [Automatically generated definition]. + EMAPA:27087 + FMA:15039 + serosa of rectum + + + + + A serous membrane that is part of a rectum [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a colon [Automatically generated definition]. + EMAPA:27387 + FMA:14990 + MA:0003199 + SCTID:90132000 + serosa of colon + + + + + A serous membrane that is part of a colon [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a duodenum [Automatically generated definition]. + EMAPA:27247 + FMA:14948 + MA:0003212 + SCTID:1236009 + serosa of duodenum + + + + + A serous membrane that is part of a duodenum [Automatically generated definition]. + OBOL:automatic + @@ -117028,8 +180162,19 @@ + A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO). + BIRNLEX:2548 + BTO:0001123 + EMAPA:32814 + MA:0001161 ganglion of peripheral nervous system + + + + A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO). + BIRNLEX:2548 + @@ -117055,8 +180200,56 @@ + A ganglion that is part of a central nervous system [Automatically generated definition]. + EHDAA2:0000227 + EMAPA:16658 + FMA:83843 ganglion of central nervous system + + + + A ganglion that is part of a central nervous system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of an anal canal [Automatically generated definition]. + EMAPA:27531 + FMA:74654 + NCIT:C60784 + SCTID:362170004 + mucosa of anal canal + + + + + A mucosa that is part of an anal canal [Automatically generated definition]. + OBOL:automatic + @@ -117081,8 +180274,54 @@ + A mucosa that is part of a oral opening [Automatically generated definition]. + SCTID:362083000 mucosa of oral region + + + + A mucosa that is part of a oral opening [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a rectum [Automatically generated definition]. + CALOHA:TS-2107 + EMAPA:27081 + FMA:15033 + MA:0003218 + SCTID:362167003 + mucosa of rectum + + + + + A mucosa that is part of a rectum [Automatically generated definition]. + OBOL:automatic + @@ -117107,8 +180346,17 @@ + A layer of epithelial cells on the surface of the mucosa. + BTO:0003752 + lies on top of lamina propria epithelium of mucosa + + + + A layer of epithelial cells on the surface of the mucosa. + BTO:0003752 + @@ -117141,8 +180389,136 @@ + An epithelium that is part of a pharynx [Automatically generated definition]. + BSA:0000112 + BTO:0005240 + EMAPA:16708 + MA:0002725 + RETIRED_EHDAA2:0001460 + TAO:0001174 + XAO:0003202 + ZFA:0001174 pharyngeal epithelium + + + + An epithelium that is part of a pharynx [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a midgut. + BTO:0005053 + EHDAA2:0001195 + EMAPA:16569 + MA:0003205 + epithelium of midgut + + + + + An epithelium that is part of a midgut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a hindgut [Automatically generated definition]. + EHDAA2:0000782 + EMAPA:16717 + MA:0003206 + epithelium of hindgut + + + + + An epithelium that is part of a hindgut [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a rectum [Automatically generated definition]. + CALOHA:TS-2066 + EHDAA2:0001594 + EMAPA:17898 + FMA:17510 + MA:0003219 + VHOG:0001037 + epithelium of rectum + + + + + An epithelium that is part of a rectum [Automatically generated definition]. + OBOL:automatic + @@ -117167,8 +180543,17 @@ + An epithelium that is part of a right lung [Automatically generated definition]. + EMAPA:17663 + MA:0003132 epithelium of right lung + + + + An epithelium that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -117193,8 +180578,17 @@ + An epithelium that is part of a left lung [Automatically generated definition]. + EMAPA:17655 + MA:0003131 epithelium of left lung + + + + An epithelium that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -117239,8 +180633,18 @@ + An unilaminar epithelium that surrounds a pectoral appendage bud. + EHDAA2:0002134 + EMAPA:16407 + VHOG:0001047 pectoral appendage bud ectoderm + + + + An unilaminar epithelium that surrounds a pectoral appendage bud. + OBOL:automatic + @@ -117265,9 +180669,20 @@ - + A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]. + EHDAA2:0004155 + EMAPA:17326 + FMA:7282 + SCTID:362018002 + VHOG:0001227 cardiac muscle of right atrium + + + + A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]. + OBOL:automatic + @@ -117292,8 +180707,20 @@ + A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]. + EHDAA2:0004154 + EMAPA:17320 + FMA:7285 + SCTID:189936008 + VHOG:0001225 cardiac muscle of left atrium + + + + A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]. + OBOL:automatic + @@ -117318,8 +180745,18 @@ + A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. + EMAPA:17342 + FMA:83452 + VHOG:0001236 cardiac muscle of right ventricle + + + + A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. + OBOL:automatic + @@ -117344,8 +180781,18 @@ + A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. + EMAPA:17339 + FMA:83453 + VHOG:0001234 cardiac muscle of left ventricle + + + + A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. + OBOL:automatic + @@ -117365,9 +180812,19 @@ - + A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]. + EHDAA2:0004158 + EMAPA:17335 + FMA:84084 + VHOG:0000999 cardiac muscle tissue of interventricular septum + + + + A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]. + OBOL:automatic + @@ -117392,8 +180849,16 @@ + A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]. + EMAPA:18963 skeletal muscle tissue of pharynx + + + + A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]. + OBOL:automatic + @@ -117425,8 +180890,18 @@ + Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi. + EMAPA:18807 + MA:0001268 smooth muscle of eye + + + + Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi. + MGI:cwg + MP:0005247 + @@ -117457,9 +180932,20 @@ - + A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]. + BTO:0001391 + EMAPA:19192 + FMA:262010 + MA:0001863 + NCIT:C49306 smooth muscle of trachea + + + + A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition]. + OBOL:automatic + @@ -117484,8 +180970,16 @@ + A mesothelium that is part of a pericardium [Automatically generated definition]. + RETIRED_EHDAA2:0001436 mesothelium of pericardial cavity + + + + A mesothelium that is part of a pericardium [Automatically generated definition]. + OBOL:automatic + @@ -117511,8 +181005,16 @@ + A mesothelium that is part of a diaphragm [Automatically generated definition]. + EMAPA:18429 mesothelium of diaphragm + + + + A mesothelium that is part of a diaphragm [Automatically generated definition]. + OBOL:automatic + @@ -117537,8 +181039,178 @@ + A mesothelium that is part of a pleural cavity [Automatically generated definition]. + BTO:0003155 + EHDAA2:0001476 + EMAPA:16775 + FMA:18148 mesothelium of pleural cavity + + + + A mesothelium that is part of a pleural cavity [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a urinary system [Automatically generated definition]. + EMAPA:17367 + MA:0003233 + mesentery of urinary system + + + + + A mesentery that is part of a urinary system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a hindgut [Automatically generated definition]. + EMAPA:16718 + mesentery of hindgut + + + + + A mesentery that is part of a hindgut [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a rectum [Automatically generated definition]. + EMAPA:18664 + mesentery of rectum + + + + + A mesentery that is part of a rectum [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a colon [Automatically generated definition]. + EMAPA:18942 + FMA:14645 + SCTID:245457004 + mesentery of colon + + + + + A mesentery that is part of a colon [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a duodenum [Automatically generated definition]. + EMAPA:19081 + mesentery of duodenum + + + + + A mesentery that is part of a duodenum [Automatically generated definition]. + OBOL:automatic + @@ -117563,8 +181235,17 @@ + A cartilage element that is part of a respiratory system [Automatically generated definition]. + EMAPA:18694 + MA:0001818 cartilage of respiratory system + + + + A cartilage element that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -117590,8 +181271,17 @@ + A gland that is part of a digestive tract [Automatically generated definition]. + EMAPA:18815 + MA:0003202 gland of digestive tract + + + + A gland that is part of a digestive tract [Automatically generated definition]. + OBOL:automatic + @@ -117622,8 +181312,20 @@ + Mesenchyme that is part of a pectoral appendage bud. + EHDAA2:0002135 + EHDAA:1703 + EMAPA:16408 + TAO:0000789 + ZFA:0000789 pectoral appendage bud mesenchyme + + + + Mesenchyme that is part of a pectoral appendage bud. + OBOL:automatic + @@ -117643,8 +181345,16 @@ + An adipose tissue that is part of a dermis [Automatically generated definition]. + MA:0000798 dermis adipose tissue + + + + An adipose tissue that is part of a dermis [Automatically generated definition]. + OBOL:automatic + @@ -117669,8 +181379,16 @@ + A nerve that is part of an abdomen [Automatically generated definition]. + MA:0000521 abdomen nerve + + + + A nerve that is part of an abdomen [Automatically generated definition]. + OBOL:automatic + @@ -117695,8 +181413,16 @@ + A nerve that is part of a neck [Automatically generated definition]. + MA:0000588 neck nerve + + + + A nerve that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -117721,8 +181447,17 @@ + Any nerve that innervates the iris. + EMAPA:35449 + MA:0001291 iris nerve + + + + Any nerve that innervates the iris. + UBERON:cjm + @@ -117747,8 +181482,16 @@ + A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk). + MA:0000515 nerve of trunk region + + + + A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk). + http://orcid.org/0000-0002-6601-2165 + @@ -117773,8 +181516,52 @@ + A nerve that is located in a thoracic cavity [Automatically generated definition]. + MA:0000556 thoracic cavity nerve + + + + A nerve that is located in a thoracic cavity [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition]. + EMAPA:36573 + FMA:84428 + MA:0002833 + trabecula carnea cardiac muscle tissue + + + + + A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition]. + OBOL:automatic + @@ -117799,8 +181586,19 @@ + A bone that is part of a head [Automatically generated definition]. + EMAPA:35996 + MA:0000576 + SCTID:118646007 + Different sources vary regarding which bones are craniofacial; e.g. hyoid bone head bone + + + + A bone that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -117825,8 +181623,16 @@ + A bone that is part of a neck [Automatically generated definition]. + MA:0000584 neck bone + + + + A bone that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -117852,8 +181658,21 @@ + A bone that is part of a facial skeleton [Automatically generated definition]. + EMAPA:19019 + EMAPA:35924 + MA:0001482 + MA:0003159 + NCIT:C63706 + SCTID:181799005 facial bone + + + + A bone that is part of a facial skeleton [Automatically generated definition]. + OBOL:automatic + @@ -117873,8 +181692,18 @@ + A bone that is part of a trunk [Automatically generated definition]. + EMAPA:36583 + MA:0000512 + SCTID:427358002 trunk bone + + + + A bone that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -117894,8 +181723,60 @@ + An artery that is part of a respiratory system [Automatically generated definition]. + MA:0001804 respiratory system artery + + + + An artery that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose. + FMA:49570 + MA:0001917 + SCTID:145137009 + Wikipedia:Superior_labial_artery + artery of upper lip + + + + + The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose. + Wikipedia:Superior_labial_artery + @@ -117927,9 +181808,19 @@ - + The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery. + FMA:49567 + MA:0001916 + SCTID:145036002 + Wikipedia:Inferior_labial_artery artery of lower lip + + + + The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery. + Wikipedia:Inferior_labial_artery + @@ -117949,8 +181840,17 @@ + An artery that is part of a thoracic cavity[cjm]. + MA:0001902 + MESH:D013895 thoracic cavity artery + + + + An artery that is part of a thoracic cavity[cjm]. + https://sourceforge.net/tracker/index.php?func=detail&aid=3317815&group_id=76834&atid=1205376 + @@ -117975,8 +181875,54 @@ + A vein that is part of a respiratory system [Automatically generated definition]. + MA:0001809 + MA:0001810 respiratory system venous blood vessel + + + + A vein that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + The inferior labial vein is the vein receiving blood from the upper lip. + FMA:52538 + MA:0002255 + SCTID:422755007 + Wikipedia:Superior_labial_vein + vein of upper lip + + + + + The inferior labial vein is the vein receiving blood from the upper lip. + Wikipedia:Superior_labial_vein + @@ -118001,9 +181947,19 @@ - + The inferior labial vein is the vein receiving blood from the lower lip. + FMA:52541 + MA:0002253 + SCTID:422955002 + Wikipedia:Inferior_labial_vein vein of lower lip + + + + The inferior labial vein is the vein receiving blood from the lower lip. + Wikipedia:Inferior_labial_vein + @@ -118023,8 +181979,49 @@ + A vein that is part of a thoracic cavity [Automatically generated definition]. + MA:0001903 thoracic cavity vein + + + + A vein that is part of a thoracic cavity [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A vein that is part of a tail [Automatically generated definition]. + AAO:0011105 + MA:0002233 + Wikipedia:Tail_vein + XAO:0000393 + tail vein + + + + + A vein that is part of a tail [Automatically generated definition]. + OBOL:automatic + Wikipedia:Tail_vein + @@ -118050,8 +182047,16 @@ + An endothelium of capillary that is part of a respiratory system [Automatically generated definition]. + MA:0001808 respiratory system capillary endothelium + + + + An endothelium of capillary that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118071,8 +182076,16 @@ + A venule that is part of a respiratory system [Automatically generated definition]. + MA:0001813 respiratory system venule + + + + A venule that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118098,8 +182111,16 @@ + An arteriole that is part of a respiratory system [Automatically generated definition]. + MA:0001803 respiratory system arteriole + + + + An arteriole that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118124,8 +182145,18 @@ + A blood vessel that is part of a head [Automatically generated definition]. + EMAPA:36610 + MA:0000575 + SCTID:127865000 head blood vessel + + + + A blood vessel that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -118150,8 +182181,16 @@ + A blood vessel that is part of an abdomen [Automatically generated definition]. + MA:0000518 abdomen blood vessel + + + + A blood vessel that is part of an abdomen [Automatically generated definition]. + OBOL:automatic + @@ -118177,8 +182216,17 @@ + A blood vessel that is part of a heart [Automatically generated definition]. + EMAPA:35397 + MA:0002483 heart blood vessel + + + + A blood vessel that is part of a heart [Automatically generated definition]. + OBOL:automatic + @@ -118204,8 +182252,17 @@ + A blood vessel that is part of a brain [Automatically generated definition]. + EMAPA:35182 + MA:0002769 brain blood vessel + + + + A blood vessel that is part of a brain [Automatically generated definition]. + OBOL:automatic + @@ -118231,8 +182288,18 @@ + A blood vessel that is part of a cornea [Automatically generated definition]. + EMAPA:36611 + MA:0001241 corneal blood vessel + + + + A blood vessel that is part of a cornea [Automatically generated definition]. + https://orcid.org/0000-0002-6601-2165 + https://sourceforge.net/tracker/index.php?func=detail&aid=3564332&group_id=36855&atid=440764 + @@ -118264,8 +182331,21 @@ + A blood vessel that is part of a retina [Automatically generated definition]. + EMAPA:36520 + GAID:509 + MA:0001317 + MESH:D012171 + SCTID:280692003 + XAO:0004153 retina blood vessel + + + + A blood vessel that is part of a retina [Automatically generated definition]. + OBOL:automatic + @@ -118290,8 +182370,16 @@ + A blood vessel that is part of a neck [Automatically generated definition]. + MA:0000583 neck blood vessel + + + + A blood vessel that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -118316,8 +182404,18 @@ + A blood vessel that is part of a respiratory system [Automatically generated definition]. + EMAPA:35731 + EMAPA:35995 + MA:0001799 respiratory system blood vessel + + + + A blood vessel that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118343,8 +182441,17 @@ + A blood vessel that is part of a trachea. + EMAPA:35874 + MA:0001852 trachea blood vessel + + + + A blood vessel that is part of a trachea. + OBOL:automatic + @@ -118369,8 +182476,18 @@ + A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta. + EMAPA:35144 + MA:0000061 + only in MA - supertype of artery, arteriole, aorta. arterial blood vessel + + + + A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta. + https://orcid.org/0000-0002-6601-2165 + @@ -118396,8 +182513,16 @@ + A blood vessel that is part of a iris [Automatically generated definition]. + MA:0001290 iris blood vessel + + + + A blood vessel that is part of a iris [Automatically generated definition]. + OBOL:automatic + @@ -118430,8 +182555,17 @@ + A blood vessel that is part of a lung [Automatically generated definition]. + EMAPA:32867 + MA:0002457 lung blood vessel + + + + A blood vessel that is part of a lung [Automatically generated definition]. + OBOL:automatic + @@ -118456,8 +182590,16 @@ + A blood vessel that is part of a trunk [Automatically generated definition]. + MA:0000511 trunk blood vessel + + + + A blood vessel that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -118482,8 +182624,51 @@ + A blood vessel that is part of a thoracic cavity [Automatically generated definition]. + MA:0000554 thoracic cavity blood vessel + + + + A blood vessel that is part of a thoracic cavity [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a tail [Automatically generated definition]. + EMAPA:35848 + MA:0000695 + tail blood vessel + + + + + A blood vessel that is part of a tail [Automatically generated definition]. + OBOL:automatic + @@ -118503,8 +182688,16 @@ + A capillary that is part of a respiratory system [Automatically generated definition]. + MA:0001807 respiratory system capillary + + + + A capillary that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118529,8 +182722,54 @@ + A gray matter that is part of a brain [Automatically generated definition]. + EMAPA:35184 + MA:0000810 + NCIT:C49333 brain gray matter + + + + A gray matter that is part of a brain [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a tail [Automatically generated definition]. + EMAPA:36502 + MA:0000700 + SCTID:67214004 + tail skin + + + + + A zone of skin that is part of a tail [Automatically generated definition]. + OBOL:automatic + @@ -118555,8 +182794,18 @@ + An alveolar duct that is part of a right lung [Automatically generated definition]. + EMAPA:35819 + MA:0001785 + NCIT:C49277 right lung alveolar duct + + + + An alveolar duct that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -118581,8 +182830,19 @@ + An alveolar duct that is part of a left lung [Automatically generated definition]. + EMAPA:19183 + MA:0001776 + NCIT:C49250 + Mice have 1 left lobe left lung alveolar duct + + + + An alveolar duct that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -118607,8 +182867,19 @@ + A bronchiole that is part of a right lung [Automatically generated definition]. + EMAPA:35425 + MA:0001787 + NCIT:C49279 + SCTID:200089000 right lung bronchiole + + + + A bronchiole that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -118633,8 +182904,19 @@ + A bronchiole that is part of a left lung [Automatically generated definition]. + EMAPA:19000 + MA:0001778 + NCIT:C49252 + SCTID:200484003 left lung bronchiole + + + + A bronchiole that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -118654,8 +182936,18 @@ + A terminal bronchiole that is part of a right lung [Automatically generated definition]. + EMAPA:36638 + MA:0001789 + NCIT:C49294 right lung terminal bronchiole + + + + A terminal bronchiole that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -118675,8 +182967,18 @@ + A terminal bronchiole that is part of a left lung [Automatically generated definition]. + EMAPA:36636 + MA:0001780 + NCIT:C49255 left lung terminal bronchiole + + + + A terminal bronchiole that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -118696,8 +182998,18 @@ + A respiratory bronchiole that is part of a right lung [Automatically generated definition]. + EMAPA:36637 + MA:0001788 + NCIT:C49285 right lung respiratory bronchiole + + + + A respiratory bronchiole that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -118717,8 +183029,18 @@ + A respiratory bronchiole that is part of a left lung [Automatically generated definition]. + EMAPA:36635 + MA:0001779 + NCIT:C49254 left lung respiratory bronchiole + + + + A respiratory bronchiole that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -118749,8 +183071,16 @@ + A portion of connective tissue that is part of a head [Automatically generated definition]. + MA:0000577 head connective tissue + + + + A portion of connective tissue that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -118775,8 +183105,16 @@ + A portion of connective tissue that is part of an abdomen [Automatically generated definition]. + MA:0000519 abdomen connective tissue + + + + A portion of connective tissue that is part of an abdomen [Automatically generated definition]. + OBOL:automatic + @@ -118801,8 +183139,16 @@ + A portion of connective tissue that is part of a neck [Automatically generated definition]. + MA:0000585 neck connective tissue + + + + A portion of connective tissue that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -118827,8 +183173,18 @@ + A portion of connective tissue that is part of a respiratory system [Automatically generated definition]. + EMAPA:35968 + EMAPA:35977 + MA:0001814 respiratory system connective tissue + + + + A portion of connective tissue that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -118859,9 +183215,17 @@ - + A portion of connective tissue that is part of a trachea. + EMAPA:35876 + MA:0001853 trachea connective tissue + + + + A portion of connective tissue that is part of a trachea. + OBOL:automatic + @@ -118887,8 +183251,16 @@ + A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]. + MA:0002409 lower respiratory tract connective tissue + + + + A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]. + OBOL:automatic + @@ -118920,8 +183292,17 @@ + A portion of connective tissue that is part of a dermis [Automatically generated definition]. + EMAPA:36509 + MA:0000799 dermis connective tissue + + + + A portion of connective tissue that is part of a dermis [Automatically generated definition]. + OBOL:automatic + @@ -118946,8 +183327,16 @@ + A portion of connective tissue that is part of a trunk [Automatically generated definition]. + MA:0000513 trunk connective tissue + + + + A portion of connective tissue that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -118972,8 +183361,19 @@ + A portion of connective tissue that is part of a bronchus [Automatically generated definition]. + EMAPA:32690 + EMAPA:35193 + MA:0001831 + NCIT:C49210 bronchus connective tissue + + + + A portion of connective tissue that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -118998,8 +183398,51 @@ + A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]. + MA:0000555 thoracic cavity connective tissue + + + + A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a tail [Automatically generated definition]. + EMAPA:16749 + MA:0000697 + tail connective tissue + + + + + A portion of connective tissue that is part of a tail [Automatically generated definition]. + OBOL:automatic + @@ -119024,8 +183467,16 @@ + A cartilage that is part of a neck [Automatically generated definition]. + MA:0000586 neck cartilage + + + + A cartilage that is part of a neck [Automatically generated definition]. + OBOL:automatic + @@ -119051,8 +183502,17 @@ + A cartilage that is part of a lower respiratory tract [Automatically generated definition]. + MA:0001819 + NCIT:C49256 lower respiratory tract cartilage + + + + A cartilage that is part of a lower respiratory tract [Automatically generated definition]. + OBOL:automatic + @@ -119083,9 +183543,25 @@ - + The ring-shaped cartilaginous structures that support the trachea. + EMAPA:18699 + EMAPA:35875 + FMA:7434 + MA:0001857 + NCIT:C49304 + SCTID:278979006 + Wikipedia:Tracheal_rings trachea cartilage + + + + The ring-shaped cartilaginous structures that support the trachea. + J:97123 + MGI:smb + MP:0003120 + http://orcid.org/0000-0002-6601-2165 + @@ -119112,8 +183588,16 @@ + A skin gland that is part of a camera-type eye [Automatically generated definition]. + MA:0002451 eye skin gland + + + + A skin gland that is part of a camera-type eye [Automatically generated definition]. + OBOL:automatic + @@ -119138,8 +183622,16 @@ + The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall. + MA:0002859 aorta elastic tissue + + + + The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall. + MP:0009862 + @@ -119166,8 +183658,16 @@ + The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers. + MA:0002858 heart elastic tissue + + + + The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers. + MP:0009863 + @@ -119193,8 +183693,16 @@ + An elastic tissue that is part of a respiratory system [Automatically generated definition]. + MA:0001820 respiratory system elastic tissue + + + + An elastic tissue that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -119219,8 +183727,16 @@ + An elastic tissue that is part of a circulatory system [Automatically generated definition]. + MA:0002857 cardiovascular system elastic tissue + + + + An elastic tissue that is part of a circulatory system [Automatically generated definition]. + OBOL:automatic + @@ -119246,8 +183762,18 @@ + Elastic tissue layer that lines a blood vessel layer. + EMAPA:36300 + MA:0002856 blood vessel elastic tissue + + + + Elastic tissue layer that lines a blood vessel layer. + http://orcid.org/0000-0002-6601-2165 + https://sourceforge.net/p/obo/mammalian-phenotype-requests/2026/ + @@ -119267,8 +183793,16 @@ + Elastic tissue that is part of a lung [Automatically generated definition]. + MA:0002860 lung elastic tissue + + + + Elastic tissue that is part of a lung [Automatically generated definition]. + OBOL:automatic + @@ -119294,8 +183828,17 @@ + An elastic tissue that is part of a bronchus [Automatically generated definition]. + MA:0001838 + NCIT:C49211 bronchus elastic tissue + + + + An elastic tissue that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -119321,9 +183864,16 @@ - + An elastic tissue that is part of a trachea [Automatically generated definition]. + MA:0001861 trachea elastic tissue + + + + An elastic tissue that is part of a trachea [Automatically generated definition]. + OBOL:automatic + @@ -119354,8 +183904,19 @@ + The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers. + EMAPA:35138 + FMA:74433 + MA:0002903 + SCTID:48467007 aorta tunica media + + + + The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers. + MP:0009873 + @@ -119387,8 +183948,20 @@ + The innermost layer of the aorta, containing the endothelium and an inner elastic membrane. + BTO:0005553 + EMAPA:35137 + FMA:74419 + MA:0002904 + SCTID:362031007 aorta tunica intima + + + + The innermost layer of the aorta, containing the endothelium and an inner elastic membrane. + MP:0009872 + @@ -119408,8 +183981,59 @@ + An arterial blood vessel that is part of a respiratory system [Automatically generated definition]. + MA:0001800 respiratory system arterial blood vessel + + + + An arterial blood vessel that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle organ that attaches to a tail vertebra [Automatically generated definition]. + AAO:0000081 + BTO:0001905 + MA:0000699 + SCTID:113230005 + post-anal tail muscle + + + + + A muscle organ that attaches to a tail vertebra [Automatically generated definition]. + OBOL:automatic + @@ -119444,8 +184068,25 @@ + The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity). + EFO:0000213 + EMAPA:36505 + FMA:12266 + GAID:17 + MA:0003057 + MESH:D034841 + NCIT:C12664 + SCTID:361294009 + Wikipedia:Abdominal_cavity + galen:AbdominalCavity abdominal cavity + + + + The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity). + UBERON:cjm + @@ -119476,8 +184117,80 @@ + In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]. + AAO:0010826 + FMA:75306 + GAID:228 + MESH:D005539 + NCIT:C12495 + SCTID:244679008 + TAO:0002045 + Wikipedia:Foramen_magnum + ZFA:0005387 + Design pattern notes: check whether this fits the foramen design pattern foramen magnum + + + + In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]. + Wikipedia:Foramen_magnum + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas. + FMA:25524 + GAID:250 + MESH:D001268 + NCIT:C32157 + SCTID:361832004 + Wikipedia:Atlanto-axial_joint + atlanto-axial joint + + + + + The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas. + Wikipedia:Atlanto-axial_joint + @@ -119502,8 +184215,91 @@ + The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles. + FMA:10429 + FMA:259054 + GAID:26 + MESH:D034861 + NCIT:C77608 + SCTID:181613000 + Wikipedia:Abdominal_wall abdominal wall + + + + The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles. + ncithesaurus:Abdominal_Wall + + + + + + + + + Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct. + FMA:14678 + GAID:281 + MA:0002659 + MESH:D017734 + NCIT:C32573 + SCTID:276158002 + extrahepatic bile duct + + + + + Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct. + MESH:A03.159.183.079 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct. + FMA:15766 + GAID:287 + MA:0001630 + MESH:D001653 + NCIT:C12677 + SCTID:362193005 + TAO:0005169 + ZFA:0005169 + intrahepatic bile duct + + + + + Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct. + MESH:A03.159.183.158 + @@ -119523,9 +184319,54 @@ - + The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava. + EHDAA2:0000182 + EHDAA:9868 + FMA:4723 + GAID:529 + MESH:D016121 + NCIT:C32816 + SCTID:181371003 + Wikipedia:Brachiocephalic_vein + galen:BrachiocephalicVein brachiocephalic vein + + + + The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava. + Wikipedia:Brachiocephalic_vein + + + + + + + + + + + + + + + A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein. + FMA:14331 + GAID:541 + MA:0002164 + MESH:D013162 + NCIT:C33608 + SCTID:278029005 + Wikipedia:Splenic_vein + galen:SplenicVein + splenic vein + + + + + A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein. + ncithesaurus:Splenic_Vein + @@ -119567,8 +184408,23 @@ + Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. + AAO:0000325 + AEO:0000123 + EHDAA2:0003123 + FMA:9642 + GAID:609 + MESH:D009417 + NCIT:C13052 + SCTID:91728009 neural tissue + + + + Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. + FMA:9642 + @@ -119599,9 +184455,21 @@ - + The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia. + BAMS:spn + FMA:5883 + GAID:800 + MESH:D013153 + SCTID:264198001 + Wikipedia:Splanchnic_nerves splanchnic nerve + + + + The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia. + MP:0008318 + @@ -119626,9 +184494,21 @@ - + The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls. + FMA:5860 + GAID:857 + MESH:D013900 + SCTID:360498003 + Wikipedia:Thoracic_nerves + neuronames:1725 thoracic nerve + + + + The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls. + MESH:A08.800.800.720.800 + @@ -119636,8 +184516,22 @@ + The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]. + EMAPA:18227 + FMA:6028 + GAID:858 + MESH:D007367 + NCIT:C32825 + SCTID:279568001 + Wikipedia:Intercostal_nerves intercostal nerve + + + + The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]. + Wikipedia:Intercostal_nerves + @@ -119686,8 +184580,24 @@ + A mucous membrane that lines the mouth. + BTO:0002860 + CALOHA:TS-0716 + EMAPA:26937 + FMA:59660 + GAID:951 + MA:0002794 + MESH:D009061 + NCIT:C77637 + Wikipedia:Oral_mucosa mouth mucosa + + + + A mucous membrane that lines the mouth. + http://orcid.org/0000-0002-6601-2165 + @@ -119712,8 +184622,18 @@ + A nerve that is part of a thorax [Automatically generated definition]. + MA:0000562 + MESH:D013900 + SCTID:359876006 nerve of thoracic segment + + + + A nerve that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -119738,8 +184658,16 @@ + A nerve that is part of an abdominal segment of trunk [Automatically generated definition]. + MA:0000528 nerve of abdominal segment + + + + A nerve that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -119759,8 +184687,17 @@ + A bone that is part of a thorax [Automatically generated definition]. + MA:0000559 + SCTID:426649006 thoracic segment bone + + + + A bone that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -119780,8 +184717,16 @@ + A bone that is part of an abdominal segment of trunk [Automatically generated definition]. + MA:0000525 abdominal segment bone + + + + A bone that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -119807,8 +184752,16 @@ + Any muscle organ that is part of a thorax [Automatically generated definition]. + MA:0000561 thoracic segment muscle + + + + Any muscle organ that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -119833,8 +184786,17 @@ + Any muscle organ that is part of a respiratory system [Automatically generated definition]. + EMAPA:35733 + MA:0001828 respiratory system muscle + + + + Any muscle organ that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -119861,8 +184823,18 @@ + Any muscle organ that is part of a esophagus [Automatically generated definition]. + EMAPA:26983 + MA:0002682 + SCTID:360961009 esophagus muscle + + + + Any muscle organ that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + @@ -119882,8 +184854,16 @@ + A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]. + MA:0000527 abdominal segment muscle + + + + A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -119908,8 +184888,16 @@ + A blood vessel that is part of a thorax [Automatically generated definition]. + MA:0000558 thoracic segment blood vessel + + + + A blood vessel that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -119934,8 +184922,16 @@ + A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]. + MA:0000524 abdominal segment blood vessel + + + + A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -119960,8 +184956,17 @@ + A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]. + FMA:264898 + MA:0000530 abdominal segment skin + + + + A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -119986,8 +184991,16 @@ + A portion of connective tissue that is part of a thorax [Automatically generated definition]. + MA:0000560 thoracic segment connective tissue + + + + A portion of connective tissue that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -120012,8 +185025,16 @@ + A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]. + MA:0000526 abdominal segment connective tissue + + + + A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]. + OBOL:automatic + @@ -120044,8 +185065,22 @@ + An anatomical space that surrounded_by a neural tube. + AAO:0011073 + EHDAA2:0001269 + EHDAA:2889 + EHDAA:914 + EMAPA:16167 + VHOG:0001119 + XAO:0000252 neural tube lumen + + + + An anatomical space that surrounded_by a neural tube. + OBOL:automatic + @@ -120070,8 +185105,20 @@ + In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]. + EHDAA2:0000719 + EHDAA:8703 + SCTID:278192008 + VHOG:0001340 + Wikipedia:Gonadal_vein gonadal vein + + + + In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]. + Wikipedia:Gonadal_vein + @@ -120097,8 +185144,21 @@ + A neural crest that has_potential_to_developmentally_contribute_to a midbrain. + EFO:0003591 + EHDAA2:0001101 + EHDAA:360 + TAO:0000935 + VHOG:0000796 + ZFA:0000935 mesencephalic neural crest + + + + A neural crest that has_potential_to_developmentally_contribute_to a midbrain. + OBOL:automatic + @@ -120124,8 +185184,21 @@ + A neural crest that has_potential_to_developmentally_contribute_to a hindbrain. + EHDAA2:0001628 + EHDAA:362 + EMAPA:35747 + TAO:0007063 + VHOG:0001210 + ZFA:0007063 rhombencephalon neural crest + + + + A neural crest that has_potential_to_developmentally_contribute_to a hindbrain. + OBOL:automatic + @@ -120150,8 +185223,19 @@ + A neural crest that has_potential_to_developmentally_contribute_to a spinal cord. + EHDAA:696 + EMAPA:16163 + EMAPA:16881 + VHOG:0001006 spinal cord neural crest + + + + A neural crest that has_potential_to_developmentally_contribute_to a spinal cord. + OBOL:automatic + @@ -120176,8 +185260,19 @@ + A neural plate that develops_from a future spinal cord. + FMA:312957 + TAO:0007021 + VHOG:0000439 + ZFA:0007021 spinal cord neural plate + + + + A neural plate that develops_from a future spinal cord. + OBOL:automatic + @@ -120203,8 +185298,19 @@ + Mesenchyme that is part of a developing gonad [Automatically generated definition]. + EHDAA:5012 + EMAPA:16858 + EMAPA:17385 + VHOG:0001090 gonad mesenchyme + + + + Mesenchyme that is part of a developing gonad [Automatically generated definition]. + OBOL:automatic + @@ -120229,8 +185335,15 @@ + A presumptive structure that has the potential to develop into a ganglion. presumptive ganglion + + + + A presumptive structure that has the potential to develop into a ganglion. + OBOL:automatic + @@ -120273,8 +185386,15 @@ + An anatomical cavity that has the potential to develop into a coelemic cavity lumen. future coelemic cavity lumen + + + + An anatomical cavity that has the potential to develop into a coelemic cavity lumen. + OBOL:automatic + @@ -120294,8 +185414,21 @@ + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. + EHDAA:251 + EMAPA:16088 + NCIT:C34195 + VHOG:0000316 + Wikipedia:Intraembryonic_coelom intraembryonic coelom + + + + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. + MGI:anna + MP:0012187 + @@ -120315,8 +185448,77 @@ + Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma. + FMA:81494 + NCIT:C67387 stroma + + + + Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum. + AAO:0011058 + BTO:0003391 + EFO:0002577 + EFO:0003428 + EHDAA2:0000744 + EHDAA:973 + EMAPA:16847 + NCIT:C34277 + TAO:0000124 + XAO:0003266 + ZFA:0000124 + liver primordium + + + + + A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum. + ISBN:3211492755 + @@ -120347,8 +185549,16 @@ + A portion of skeletal muscle tissue in the trunk. + SCTID:244848007 skeletal muscle tissue of trunk + + + + A portion of skeletal muscle tissue in the trunk. + http://orcid.org/0000-0002-6601-2165 + @@ -120385,9 +185595,29 @@ - + The part of the retina that contains neurons and photoreceptor cells[GO]. + AAO:0011095 + BTO:0000929 + CALOHA:TS-0685 + EHDAA2:0001253 + EHDAA:4763 + EMAPA:17171 + EMAPA:18590 + FMA:58628 + MA:0000277 + NCIT:C33166 + TAO:0000046 + VHOG:0000535 + XAO:0003216 + ZFA:0000046 retinal neural layer + + + + The part of the retina that contains neurons and photoreceptor cells[GO]. + GO:0003407 + @@ -120395,8 +185625,20 @@ + Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]. + FMA:63131 + SCTID:340163004 + TAO:0005261 + Wikipedia:Sinusoid_(blood_vessel) + ZFA:0005261 sinusoid + + + + Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]. + Wikipedia:Sinusoid_(blood_vessel) + @@ -120416,8 +185658,18 @@ + Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + AEO:0000114 + EHDAA2:0003114 epithelial tube + + + + Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + GO:0060562 + PMID:12526790 + @@ -120437,8 +185689,15 @@ + Any endothelium that has the quality of being cylindrical [Automatically generated definition]. endothelial tube + + + + Any endothelium that has the quality of being cylindrical [Automatically generated definition]. + OBOL:automatic + @@ -120463,9 +185722,206 @@ - + A blood vessel that carries blood from the capillaries toward the heart. + EMAPA:35932 + FMA:86188 + MA:0000066 + Compare to: vein venous blood vessel + + + + A blood vessel that carries blood from the capillaries toward the heart. + http://www.thefreedictionary.com/venous+blood+vessel + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Embryonic structure that develops into pancreatic bud. + EFO:0002579 + EFO:0003434 + EHDAA2:0001382 + EHDAA:2163 + EMAPA:17066 + FMA:79792 + TAO:0000254 + XAO:0001101 + ZFA:0000254 + pancreas primordium + + + + + Embryonic structure that develops into pancreatic bud. + Wikipedia:Pancreas#Embryological_development + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]. + EFO:0003470 + EMAPA:35645 + NCIT:C34242 + SCTID:360398004 + TAO:0001390 + Wikipedia:Pancreatic_bud + ZFA:0001390 + pancreatic epithelial bud + + + + + The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]. + PMID:16417468 + Wikipedia:Pancreatic_bud + + + + + + + + + + + + + + + + + + + + + Pancreatic bud that gives rise to the accessory pancreatic duct. + AAO:0011031 + EFO:0003465 + EHDAA2:0001385 + EMAPA:17067 + SCTID:361435005 + TAO:0001370 + VHOG:0001428 + Wikipedia:Pancreatic_bud + XAO:0000467 + ZFA:0001370 + dorsal pancreatic bud + + + + + Pancreatic bud that gives rise to the accessory pancreatic duct. + Wikipedia:Pancreatic_bud + + + + + + + + + + + + + + + + + + + + + Pancreatic bud that gives rise to the major pancreatic duct. + AAO:0011111 + EFO:0003464 + EHDAA2:0001389 + EMAPA:17256 + SCTID:361437002 + TAO:0001369 + VHOG:0001429 + Wikipedia:Pancreatic_bud + XAO:0001103 + ZFA:0001369 + ventral pancreatic bud + + + + + Pancreatic bud that gives rise to the major pancreatic duct. + Wikipedia:Pancreatic_bud + @@ -120490,8 +185946,17 @@ + A duct that is part of a digestive system [Automatically generated definition]. + TAO:0005162 + ZFA:0005162 digestive system duct + + + + A duct that is part of a digestive system [Automatically generated definition]. + OBOL:automatic + @@ -120516,8 +185981,23 @@ + An epithelium that lines the lumen of the digestive tract. + BTO:0000956 + EHDAA2:0004567 + EMAPA:32928 + MA:0003201 + NCIT:C12963 + TAO:0005123 + XAO:0003200 + ZFA:0005123 digestive tract epithelium + + + + An epithelium that lines the lumen of the digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -120542,8 +186022,18 @@ + A cartilage element of chondrocranium. Example: neurocranial trabecula. + EFO:0003690 + TAO:0001461 + ZFA:0001461 cartilage element of chondrocranium + + + + A cartilage element of chondrocranium. Example: neurocranial trabecula. + https://orcid.org/0000-0002-6601-2165 + @@ -120568,8 +186058,18 @@ + A cartilage element that is part of the cranial skeleton. + TAO:0001458 + ZFA:0001458 cranial cartilage + + + + A cartilage element that is part of the cranial skeleton. + ZFA:0001458 + https://orcid.org/0000-0002-6601-2165 + @@ -120589,8 +186089,16 @@ + Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction. + MA:0001751 reproductive gland + + + + Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction. + MP:0000653 + @@ -120610,8 +186118,18 @@ + The sensory system for the sense of touch and pain. + NLXANAT:090818 + Wikipedia:Somatosensory_system + neuronames:2887 somatosensory system + + + + The sensory system for the sense of touch and pain. + NLXANAT:090818 + @@ -120649,9 +186167,15 @@ - + The anterior segment of the lamellated connective tissue layer of the cornea. anterior stroma of cornea + + + + The anterior segment of the lamellated connective tissue layer of the cornea. + MP:0003093 + @@ -120689,8 +186213,15 @@ + The posterior segment of the lamellated connective tissue layer of the cornea. posterior stroma of cornea + + + + The posterior segment of the lamellated connective tissue layer of the cornea. + MP:0003094 + @@ -120722,8 +186253,15 @@ + The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity. cutaneous elastic tissue + + + + The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity. + MP:0008418 + @@ -120743,9 +186281,19 @@ - + The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina. + BTO:0003099 + FMA:45654 + SCTID:303518005 + TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 internal female genitalia + + + + The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina. + MP:0009209 + @@ -120780,8 +186328,15 @@ + The connection between the embryo proper and extraembryonic tissues. embryonic-extraembryonic boundary + + + + The connection between the embryo proper and extraembryonic tissues. + MP:0003890 + @@ -120795,8 +186350,28 @@ + A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. + AAO:0011028 + AEO:0001017 + EHDAA2_RETIRED:0003428 + EHDAA:1719 + EHDAA:1725 + EHDAA:1731 + EHDAA:1737 + EMAPA:32838 + FMA:295656 + NCIT:C61572 + Wikipedia:Dermatome_(embryology) + XAO:0000220 dermatome + + + + A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. + AEO:0001017 + AEO:JB + @@ -120825,8 +186400,55 @@ + The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells. germinal neuroepithelium + + + + The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells. + MP:0004261 + http://www.ncbi.nlm.nih.gov/books/NBK10047 + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]. + BTO:0002840 + TAO:0005164 + ZFA:0005164 + biliary ductule + + + + + One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]. + BTO:0002840 + MP:0009494 + @@ -120854,8 +186476,20 @@ + The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium. + EMAPA:17152 + EMAPA:35362 + EMAPA_RETIRED:16783 + MA:0003193 neural tube ventricular layer + + + + The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium. + MP:0009689 + http://www.ncbi.nlm.nih.gov/books/NBK10047 + @@ -120889,8 +186523,19 @@ + The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. + EMAPA:17148 + EMAPA:35360 + neuronames:1367 neural tube mantle layer + + + + The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. + MP:0009690 + http://www.ncbi.nlm.nih.gov/books/NBK10047 + @@ -120917,8 +186562,18 @@ + The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter. + EMAPA:17151 + neuronames:1368 neural tube marginal layer + + + + The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter. + MP:0009691 + http://www.ncbi.nlm.nih.gov/books/NBK10047 + @@ -120957,8 +186612,94 @@ + The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons. + AAO:0010561 + EFO:0001904 + NCIT:C34111 + Wikipedia:Basal_plate_(neural_tube) + neuronames:1372 neural tube basal plate + + + + The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons. + MP:0009693 + Wikipedia:Basal_plate_(neural_tube) + http://www.ncbi.nlm.nih.gov/books/NBK10047 + + + + + + + + + + + + + + + The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout. + EHDAA2:0000578 + EHDAA:4778 + EMAPA:16681 + FMA:293101 + NCIT:C34182 + SCTID:361486000 + VHOG:0001319 + Wikipedia:Frontonasal_prominence + frontonasal prominence + + + + + The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout. + MP:0009901 + + + + + + + + + + + + + + + + + + + + + + + + + + + The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it. + EHDAA2:0001076 + EHDAA:4792 + EMAPA:16808 + FMA:295858 + SCTID:308877001 + VHOG:0000804 + Wikipedia:Medial_nasal_prominence + medial nasal prominence + + + + + The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it. + MP:0009903 + Wikipedia:Medial_nasal_prominence + @@ -120967,8 +186708,26 @@ + Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart. + AAO:0010215 + BTO:0001438 + EMAPA:18415 + FMA:321896 + GAID:547 + MA:0000068 + MESH:D014684 + NCIT:C12817 + SCTID:244405007 + Wikipedia:Venae_cavae vena cava + + + + Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart. + Wikipedia:Venae_cavae + http://orcid.org/0000-0002-6601-2165 + @@ -120982,8 +186741,53 @@ + The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present. + FMA:260119 orbital region + + + + The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + The middle of the face including the nose and its associated bony structures[MW]. + FMA:285406 + MA:0001910 + midface + + + + + The middle of the face including the nose and its associated bony structures[MW]. + HP:0000309 + http://www.merriam-webster.com/medical/midface + @@ -121025,11 +186829,20 @@ - - - + Any tube, opening or passage that connects two distinct anatomical spaces. + AEO:0000080 + EHDAA2:0003080 + FMA:242873 + SCTID:346902003 + Wikipedia:Foramen anatomical conduit + + + + Any tube, opening or passage that connects two distinct anatomical spaces. + http://orcid.org/0000-0002-6601-2165 + @@ -121054,8 +186867,16 @@ + A vasculature that is part of a iris [Automatically generated definition]. + ZFA:0005568 vasculature of iris + + + + A vasculature that is part of a iris [Automatically generated definition]. + OBOL:automatic + @@ -121080,8 +186901,15 @@ + An anatomical structure that develops (entirely or partially) from the endoderm. endoderm-derived structure + + + + An anatomical structure that develops (entirely or partially) from the endoderm. + https://orcid.org/0000-0002-6601-2165 + @@ -121106,8 +186934,15 @@ + An anatomical structure that develops (entirely or partially) from the mesoderm. mesoderm-derived structure + + + + An anatomical structure that develops (entirely or partially) from the mesoderm. + https://orcid.org/0000-0002-6601-2165 + @@ -121132,8 +186967,202 @@ + An anatomical structure that develops (entirely or partially) from the ectoderm. ectoderm-derived structure + + + + An anatomical structure that develops (entirely or partially) from the ectoderm. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction. + AAO:0000624 + BILA:0000122 + BTO:0003091 + EFO:0003864 + EHDAA:1013 + EMAPA:16367 + EV:0100094 + FMA:280610 + GAID:362 + MESH:D014566 + NCIT:C12810 + SCTID:278861008 + VHOG:0000286 + XAO:0000140 + galen:GenitoUrinarySystem + genitourinary system + + + + + Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction. + VHOG:0000286 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any of the layers of the myocardium. Example: compact layer, trabecular layer. + MA:0000080 + myocardial layer + + + + + Any of the layers of the myocardium. Example: compact layer, trabecular layer. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA]. + EFO:0003706 + MA:0002866 + TAO:0005059 + ZFA:0005059 + myocardium trabecular layer + + + + + The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA]. + ZFA:0005059 + + + + + + + + + + + + + + + + + + + + + + + + + + A myocardium trabecular layer that is part of a cardiac ventricle. + FMA:83511 + TAO:0005060 + ZFA:0005060 + trabecular layer of ventricle + + + + + A myocardium trabecular layer that is part of a cardiac ventricle. + OBOL:automatic + @@ -121166,8 +187195,28 @@ + The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]. + AAO:0011039 + EHDAA2:0001320 + EMAPA:16540 + FMA:293357 + NCIT:C34236 + SCTID:362864008 + TAO:0000050 + VHOG:0000165 + Wikipedia:Optic_vesicles + XAO:0000228 + ZFA:0000050 + Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 "Developmental Biology"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288] optic vesicle + + + + The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]. + GO:0003404 + Wikipedia:Optic_vesicles + @@ -121182,8 +187231,15 @@ + Missing definition for term UBERON:0004133. Please replace it using linked reference. salivatory nucleus + + + + Missing definition for term UBERON:0004133. Please replace it using linked reference. + GO:0021751 + @@ -121197,8 +187253,18 @@ + The first recognizable structure derived from the heart field. + EHDAA2:0000215 + EMAPA:16106 + VHOG:0000975 cardiogenic plate + + + + The first recognizable structure derived from the heart field. + GO:0003142 + @@ -121221,8 +187287,18 @@ + A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. + XAO:0004185 primary heart field + + + + A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. + GO:0003138 + GOC:mtg_heart + GOC:rl + @@ -121238,8 +187314,23 @@ + An epithelial tube that will give rise to the mature heart. + AAO:0010411 + EFO:0003526 + EMAPA:32685 + NCIT:C34161 + TAO:0000360 + XAO:0000337 + ZFA:0000360 heart tube + + + + An epithelial tube that will give rise to the mature heart. + GO:0003143 + GOC:mtg_heart + @@ -121264,8 +187355,16 @@ + The outflow tract septum is a partition in the outflow tract. + XAO:0004141 outflow tract septum + + + + The outflow tract septum is a partition in the outflow tract. + GO:0003148 + @@ -121298,8 +187397,22 @@ + The outflow tract is the portion of the heart through which blood flows into the arteries. + EHDAA2:0001351 + EHDAA:464 + EHDAA:798 + EMAPA:16346 + MA:0000100 + VHOG:0000670 + XAO:0004139 outflow tract + + + + The outflow tract is the portion of the heart through which blood flows into the arteries. + GO:0003151 + @@ -121320,8 +187433,16 @@ + The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. His-Purkinje system + + + + The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. + GO:0003164 + https://github.com/geneontology/go-ontology/issues/12451 + @@ -121352,8 +187473,23 @@ + Vein of heart that drains the myocardium. + EHDAA2:0004507 + FMA:12846 + NCIT:C12878 + NCIT:C12882 + SCTID:277726009 + Wikipedia:Coronary_circulation + ZFA:0005814 + galen:CoronaryVein cardiac vein + + + + Vein of heart that drains the myocardium. + http://orcid.org/0000-0002-6601-2165 + @@ -121368,8 +187504,18 @@ + A cardiac chamber surrounds an enclosed cavity within the heart. + FMA:7095 + SCTID:276456008 + generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus cardiac chamber + + + + A cardiac chamber surrounds an enclosed cavity within the heart. + GO:0003205 + @@ -121389,8 +187535,18 @@ + An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium. + EMAPA:36025 + ZFA:0005808 proepicardium + + + + An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium. + GO:0003342 + http://en.wiktionary.org/wiki/proepicardium + @@ -121410,8 +187566,24 @@ + A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]. + EHDAA2:0001829 + EHDAA:736 + EMAPA:16318 + FMA:295593 + NCIT:C34296 + SCTID:308819008 + VHOG:0000019 + Wikipedia:Septum_transversum septum transversum + + + + A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]. + VHOG:0000019 + Wikipedia:Septum_transversum + @@ -121419,9 +187591,17 @@ - + The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. + FMA:45652 + TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 internal genitalia + + + + The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. + GO:0035260 + @@ -121429,8 +187609,18 @@ + The external genitalia are the outer sex organs, such as the penis or vulva in mammals. + FMA:45643 + SCTID:362207005 + TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547 external genitalia + + + + The external genitalia are the outer sex organs, such as the penis or vulva in mammals. + GO:0035261 + @@ -121456,8 +187646,19 @@ + Organ that is part of the hematopoietic system. + BTO:0004605 + FMA:7143 + MA:0000747 + SCTID:361338006 hemopoietic organ + + + + Organ that is part of the hematopoietic system. + GOC:Obol + @@ -121483,8 +187684,22 @@ + The nonstriated, involuntary muscle tissue located in the wall of the aorta. + BTO:0001685 + CALOHA:TS-0048 + EFO:0002775 + EMAPA:35135 + MA:0000702 + NCIT:C49191 aorta smooth muscle tissue + + + + The nonstriated, involuntary muscle tissue located in the wall of the aorta. + MGI:csmith + MP:0009865 + @@ -121508,8 +187723,16 @@ + A portions of the gut that is derived from endoderm. + EMAPA:32930 endodermal part of digestive tract + + + + A portions of the gut that is derived from endoderm. + GO:0061031 + @@ -121534,8 +187757,107 @@ + A nerve that is part of a back [Automatically generated definition]. + MA:0000497 back nerve + + + + A nerve that is part of a back [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]. + EMAPA:35469 + MA:0001547 + large intestine smooth muscle + + + + + A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]. + BTO:0000643 + EMAPA:35441 + EMAPA:35443 + MA:0001539 + NCIT:C49243 + intestine smooth muscle + + + + + A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]. + OBOL:automatic + @@ -121560,8 +187882,18 @@ + A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]. + BTO:0001818 + EMAPA:35823 + MA:0001627 stomach smooth muscle + + + + A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]. + OBOL:automatic + @@ -121586,8 +187918,18 @@ + A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]. + BTO:0001660 + EMAPA:35734 + MA:0001830 respiratory system smooth muscle + + + + A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -121612,8 +187954,51 @@ + A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]. + EMAPA:35117 + MA:0001523 gastrointestinal system smooth muscle + + + + A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]. + MA:0001532 + anal region smooth muscle + + + + + A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]. + OBOL:automatic + @@ -121639,8 +188024,17 @@ + A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]. + EMAPA:35520 + MA:0002410 lower respiratory tract smooth muscle + + + + A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]. + OBOL:automatic + @@ -121665,8 +188059,19 @@ + A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]. + BTO:0000655 + EMAPA:35448 + FMA:312338 + MA:0001270 iris smooth muscle + + + + A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]. + OBOL:automatic + @@ -121692,8 +188097,18 @@ + A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]. + EMAPA:36287 + FMA:312251 + MA:0000706 arteriole smooth muscle + + + + A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]. + OBOL:automatic + @@ -121718,9 +188133,137 @@ - + Smooth muscle found within, and composing the majority of the wall of blood vessels. + BTO:0001431 + CALOHA:TS-1107 + EMAPA:35177 + MA:0000710 + MESH:D009131 + NCIT:C33853 + TAO:0005321 + Wikipedia:Vascular_smooth_muscle + ZFA:0005321 blood vessel smooth muscle + + + + Smooth muscle found within, and composing the majority of the wall of blood vessels. + Wikipedia:Vascular_smooth_muscle + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]. + EMAPA:35807 + MA:0000757 + spleen smooth muscle + + + + + A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]. + EMAPA:35783 + MA:0001559 + small intestine smooth muscle + + + + + A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]. + EMAPA:35373 + MA:0001635 + NCIT:C49483 + gallbladder smooth muscle + + + + + A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]. + OBOL:automatic + @@ -121751,9 +188294,19 @@ - + A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]. + BTO:0004401 + EMAPA:35195 + MA:0001840 + NCIT:C49213 bronchus smooth muscle + + + + A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition]. + OBOL:automatic + @@ -121778,8 +188331,16 @@ + A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]. + MA:0000492 outflow tract smooth muscle + + + + A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]. + OBOL:automatic + @@ -121799,8 +188360,16 @@ + A bone that is part of the dorsal region of an animal. + MA:0000494 bone of dorsum + + + + A bone that is part of the dorsal region of an animal. + http://orcid.org/0000-0002-6601-2165 + @@ -121831,8 +188400,19 @@ + Any muscle organ that is part of a skin of body [Automatically generated definition]. + EMAPA:18187 + EMAPA:35776 + MA:0002710 + MA:0003139 skin muscle + + + + Any muscle organ that is part of a skin of body [Automatically generated definition]. + OBOL:automatic + @@ -121857,8 +188437,16 @@ + A blood vessel that is part of a back [Automatically generated definition]. + MA:0000493 back blood vessel + + + + A blood vessel that is part of a back [Automatically generated definition]. + OBOL:automatic + @@ -121883,8 +188471,19 @@ + A myocardium that is part of a outflow tract [Automatically generated definition]. + EHDAA2:0001358 + EMAPA:35623 + MA:0000489 + VHOG:0000603 outflow tract myocardium + + + + A myocardium that is part of a outflow tract [Automatically generated definition]. + OBOL:automatic + @@ -121909,8 +188508,16 @@ + A portion of connective tissue that is part of a back [Automatically generated definition]. + MA:0000495 back connective tissue + + + + A portion of connective tissue that is part of a back [Automatically generated definition]. + OBOL:automatic + @@ -121936,8 +188543,16 @@ + A pericardium that is part of a outflow tract [Automatically generated definition]. + MA:0000491 outflow tract pericardium + + + + A pericardium that is part of a outflow tract [Automatically generated definition]. + OBOL:automatic + @@ -121969,8 +188584,18 @@ + A muscle that is part of the eye region. + AAO:0000156 + EMAPA:35335 + MA:0000271 eye muscle + + + + A muscle that is part of the eye region. + OBOL:automatic + @@ -121991,9 +188616,30 @@ - + Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. + AEO:0000168 + EHDAA2:0001843 + EHDAA:5047 + EMAPA:17213 + FMA:23875 + GAID:177 + MA:0003006 + MAT:0000032 + MESH:D012863 + MIAA:0000032 + SCTID:361378004 + VSAO:0000026 + Wikipedia:Skeleton + XAO:0004053 + galen:Skeleton skeleton + + + + Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. + VSAO:0000026 + @@ -122014,8 +188660,24 @@ + The bilaminar epithelium formed from the myotome and dermatome. + AAO:0010572 + AEO:0000214 + EHDAA2:0003259 + EMAPA:31109 + FMA:295654 + NCIT:C34140 + TAO:0001513 + VHOG:0000676 + ZFA:0001513 dermomyotome + + + + The bilaminar epithelium formed from the myotome and dermatome. + AEO:0000214 + @@ -122029,8 +188691,17 @@ + A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. + TAO:0000115 + ZFA:0000115 heart rudiment + + + + A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. + GO:0003313 + @@ -122057,8 +188728,19 @@ + Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart. + EMAPA:36645 + FMA:9496 + Wikipedia:Cardiac_skeleton cardiac skeleton + + + + Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart. + GO:0003204 + Wikipedia:Cardiac_skeleton + @@ -122084,8 +188766,16 @@ + A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]. + MA:0001806 respiratory system blood vessel smooth muscle + + + + A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -122112,8 +188802,20 @@ + Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition. + BTO:0001840 + EHDAA2:0002091 + EHDAA:56 + EMAPA:16046 + VHOG:0000979 trophectoderm + + + + Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition. + MP:0005028 + @@ -122127,8 +188829,19 @@ + The embryonic structure that gives rise to the corneal ectoderm. + EHDAA:938 + EMAPA:16322 + RETIRED_EHDAA2:0001308 + VHOG:0001296 optic eminence + + + + The embryonic structure that gives rise to the corneal ectoderm. + MP:0006305 + @@ -122172,8 +188885,23 @@ + Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. + AAO:0010760 + EMAPA:32744 + NCIT:C34109 + TAO:0002146 + Wikipedia:Apical_ectodermal_ridge + XAO:0004121 + ZFA:0001702 apical ectodermal ridge + + + + Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. + MP:0001676 + Wikipedia:Apical_ectodermal_ridge + @@ -122200,8 +188928,19 @@ + An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. + VHOG:0001258 + Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056] paired limb/fin bud + + + + An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. + ISBN:9780878932504 + MP:0005650 + https://orcid.org/0000-0002-6601-2165 + @@ -122209,8 +188948,29 @@ + The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries. + AAO:0010364 + CALOHA:TS-2089 + EHDAA2:0000006 + EHDAA:573 + EMAPA:16118 + FMA:293019 + MFMO:0000095 + NCIT:C34175 + SCTID:308767008 + TAO:0001595 + VHOG:0000296 + Wikipedia:First_pharyngeal_arch + XAO:0000097 + ZFA:0001612 pharyngeal arch 1 + + + + The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries. + http://orcid.org/0000-0002-6601-2165 + @@ -122245,8 +189005,27 @@ + One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]. + AAO:0010414 + EFO:0003695 + EHDAA2:0000186 + EHDAA:398 + EHDAA:7327 + EMAPA:16684 + NCIT:C32123 + TAO:0005004 + VHOG:0000122 + Wikipedia:Aortic_arches + XAO:0000341 + ZFA:0005004 pharyngeal arch artery + + + + One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]. + MP:0002672 + @@ -122260,8 +189039,18 @@ + Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta. + BTO:0001715 + EMAPA:16059 ectoplacental cone + + + + Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta. + MP:0001717 + PMID:19829370 + @@ -122292,8 +189081,16 @@ + Blood vessel that is connected to the yolk sac. + EMAPA:36494 vitelline blood vessel + + + + Blood vessel that is connected to the yolk sac. + http://orcid.org/0000-0002-6601-2165 + @@ -122351,8 +189148,27 @@ + A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]. + EMAPA:18804 + FMA:58309 + GAID:894 + MA:0001246 + MESH:D003886 + NCIT:C32454 + SCTID:281076002 + TAO:0002157 + Wikipedia:Descemet%27s_membrane + ZFA:0001686 + The strong, resistant, thin, noncellular fourth layer of the cornea, located between the endothelium (from which it is secreted) and the stroma. (Cline et al., Dictionary of Visual Science, 4th ed) Descemet's membrane + + + + A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]. + MP:0004285 + https://github.com/obophenotype/uberon/issues/15 + @@ -122388,8 +189204,22 @@ + A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane. + FMA:58273 + MA:0001240 + NCIT:C32226 + SCTID:281075003 + TAO:0002155 + Wikipedia:Bowman%27s_membrane + ZFA:0001684 anterior limiting lamina of cornea + + + + A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane. + ncithesaurus:Bowman_s_Membrane + @@ -122414,8 +189244,16 @@ + Vascular network that is connected to the yolk sac. + Wikipedia:Vitelline_circulation vitelline vasculature + + + + Vascular network that is connected to the yolk sac. + http://orcid.org/0000-0002-6601-2165 + @@ -122441,8 +189279,58 @@ + A bone that is part of an appendage [Automatically generated definition]. bone of free limb or fin + + + + A bone that is part of an appendage [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra. + MA:0002869 + XAO:0003077 + trunk or cervical vertebra + + + + + A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra. + UBERONREF:0000006 + @@ -122473,8 +189361,18 @@ + An embryo at the neurula stage. + BILA:0000061 + BTO:0001766 + NCIT:C34229 neurula embryo + + + + An embryo at the neurula stage. + http://orcid.org/0000-0002-6601-2165 + @@ -122495,8 +189393,16 @@ + Sum of all sensory systems in an organism. + FMA:78499 entire sense organ system + + + + Sum of all sensory systems in an organism. + http://orcid.org/0000-0002-6601-2165 + @@ -122543,8 +189449,18 @@ + Any collection of skeletal muscles that is part of a head [Automatically generated definition]. + EMAPA:18171 + FMA:71287 + This class is restricted to skeletal muscles that attach to the cranial skeleton. This seems to be consistent with FMA and EMAPA usage. Note that by definition this excludes invertebrate head musculature. It corresponds to the individual muscle organ term UBERON:0002376 skeletal musculature of head + + + + Any collection of skeletal muscles that is part of a head [Automatically generated definition]. + OBOL:automatic + @@ -122569,8 +189485,17 @@ + Any collection of muscles that is part of a thorax [Automatically generated definition]. + BTO:0000508 + FMA:71293 musculature of thorax + + + + Any collection of muscles that is part of a thorax [Automatically generated definition]. + OBOL:automatic + @@ -122595,8 +189520,46 @@ + Any collection of muscles that is part of a neck [Automatically generated definition]. + AAO:0000091 + EMAPA:36050 + FMA:71290 + MESH:D009334 musculature of neck + + + + Any collection of muscles that is part of a neck [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:33061 + set of muscles of vertebral column + @@ -122621,8 +189584,16 @@ + Any collection of muscles that is part of a back [Automatically generated definition]. + FMA:71291 musculature of back + + + + Any collection of muscles that is part of a back [Automatically generated definition]. + OBOL:automatic + @@ -122647,8 +189618,17 @@ + A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles. + AAO:0000423 + FMA:33519 musculature of pectoral girdle + + + + A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles. + https://orcid.org/0000-0002-6601-2165 + @@ -122673,8 +189653,16 @@ + Any collection of muscles that is part of a face. + FMA:71288 musculature of face + + + + Any collection of muscles that is part of a face. + OBOL:automatic + @@ -122699,8 +189687,18 @@ + Any collection of muscles that is part of a trunk [Automatically generated definition]. + AAO:0011572 + EFO:0003531 + FMA:50187 musculature of trunk + + + + Any collection of muscles that is part of a trunk [Automatically generated definition]. + OBOL:automatic + @@ -122725,8 +189723,16 @@ + A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]. + FMA:7283 cardiac muscle tissue of atrium + + + + A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]. + OBOL:automatic + @@ -122751,8 +189757,16 @@ + A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]. + FMA:84083 cardiac muscle tissue of interatrial septum + + + + A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]. + OBOL:automatic + @@ -122777,8 +189791,16 @@ + A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]. + FMA:226279 cardiac muscle tissue of cardiac septum + + + + A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]. + OBOL:automatic + @@ -122803,8 +189825,17 @@ + A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]. + FMA:261726 + MA:0002441 cardiac muscle tissue of myocardium + + + + A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]. + OBOL:automatic + @@ -122830,8 +189861,16 @@ + A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition]. + FMA:261898 skeletal muscle tissue of diaphragm + + + + A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition]. + OBOL:automatic + @@ -122856,9 +189895,16 @@ - + A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]. + FMA:261045 smooth muscle tissue of bronchiole + + + + A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -122889,9 +189935,16 @@ - + A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]. + FMA:261051 smooth muscle tissue of terminal bronchiole + + + + A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -122922,9 +189975,50 @@ - + A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition]. + FMA:261055 smooth muscle tissue of respiratory bronchiole + + + + A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle that is attached to a vertebra of the vertebral column. + FMA:22594 + muscle of vertebral column + + + + + A muscle that is attached to a vertebra of the vertebral column. + https://orcid.org/0000-0002-6601-2165 + @@ -122949,8 +190043,16 @@ + A vasculature that is part of a muscle organ [Automatically generated definition]. + FMA:87123 vasculature of muscle organ + + + + A vasculature that is part of a muscle organ [Automatically generated definition]. + OBOL:automatic + @@ -122975,8 +190077,86 @@ + A vasculature that is part of a musculoskeletal system [Automatically generated definition]. + FMA:239607 vasculature of musculoskeletal system + + + + A vasculature that is part of a musculoskeletal system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. + FMA:84429 + cardiac muscle tissue of trabecula carnea of right ventricle + + + + + A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. + FMA:84430 + cardiac muscle tissue of trabecula carnea of left ventricle + + + + + A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. + OBOL:automatic + @@ -123021,9 +190201,37 @@ - + Anatomical system that has as its parts the heart and blood vessels. + AAO:0011001 + BILA:0000016 + BTO:0000088 + CALOHA:TS-1297 + EFO:0000791 + EHDAA:394 + EMAPA:16104 + EV:0100017 + FMA:7161 + GAID:467 + MA:0000010 + MAT:0000016 + MESH:D002319 + MIAA:0000016 + NCIT:C12686 + SCTID:278198007 + TAO:0000010 + VHOG:0000302 + WikipediaCategory:Cardiovascular_system + XAO:0000100 + XAO:0001010 + ZFA:0000010 cardiovascular system + + + + Anatomical system that has as its parts the heart and blood vessels. + BTO:0000088 + @@ -123048,9 +190256,17 @@ - + A vascular network consisting of blood vessels. + TAO:0001079 + ZFA:0001079 blood vasculature + + + + A vascular network consisting of blood vessels. + https://orcid.org/0000-0002-6601-2165 + @@ -123076,8 +190292,19 @@ + An eye that is part of a left side of organism [Automatically generated definition]. + FMA:12515 + MA:0002949 + NCIT:C119334 + SCTID:362503005 left eye + + + + An eye that is part of a left side of organism [Automatically generated definition]. + OBOL:automatic + @@ -123103,8 +190330,19 @@ + An eye that is part of a right side of organism [Automatically generated definition]. + FMA:12514 + MA:0002950 + NCIT:C119333 + SCTID:362502000 right eye + + + + An eye that is part of a right side of organism [Automatically generated definition]. + OBOL:automatic + @@ -123118,8 +190356,18 @@ + The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart. + FMA:45623 + Wikipedia:Systemic_circulation#Arteries systemic arterial system + + + + The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart. + Wikipedia:Systemic_circulation#Arteries + http://orcid.org/0000-0002-6601-2165 + @@ -123133,9 +190381,23 @@ - + The part of the cardiovascular system consisting of all arteries. + BTO:0004690 + EHDAA2:0000143 + EHDAA:396 + EMAPA:16201 + EMAPA:16371 + MA:0002719 + SCTID:362030008 + VHOG:0000273 arterial system + + + + The part of the cardiovascular system consisting of all arteries. + https://orcid.org/0000-0002-6601-2165 + @@ -123160,9 +190422,18 @@ - + An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart. + FMA:66464 + Wikipedia:Artery#Systemic_arteries systemic artery + + + + An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart. + Wikipedia:Artery#Systemic_arteries + http://orcid.org/0000-0002-6601-2165 + @@ -123176,8 +190447,18 @@ + The part of the venous system that drains the general body tissues[Kardong]. + FMA:45626 + Wikipedia:Systemic_venous_system systemic venous system + + + + The part of the venous system that drains the general body tissues[Kardong]. + ISBN:0073040584 + Wikipedia:Systemic_venous_system + @@ -123191,9 +190472,42 @@ - + The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions. + BTO:0004692 + EHDAA2:0002171 + EHDAA:486 + EMAPA:16240 + MA:0002720 + NCIT:C33858 + SCTID:362060003 + VHOG:0000277 venous system + + + + The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. + FMA:75004 + NCIT:C28381 + Wikipedia:Sphincter + sphincter muscle + + + + + A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. + Wikipedia:Sphincter + @@ -123218,9 +190532,64 @@ - + An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart. + BTO:0000766 + CALOHA:TS-2155 + EMAPA:35176 + MA:0000709 + NCIT:C53395 + TAO:0005257 + ZFA:0005257 blood vessel endothelium + + + + An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein. + EMAPA:35499 + FMA:14471 + MA:0002494 + NCIT:C32732 + SCTID:362194004 + Wikipedia:Lobules_of_liver + liver lobule + + + + + The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein. + ISBN:0-683-40008-8 + MP:0008987 + @@ -123251,8 +190620,18 @@ + An anatomical wall that is part of an aorta, enclosing the luminal space. + EMAPA:35139 + FMA:14156 + MA:0002901 aorta wall + + + + An anatomical wall that is part of an aorta, enclosing the luminal space. + http://orcid.org/0000-0002-6601-2165 + @@ -123283,8 +190662,20 @@ + The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers. + EMAPA:35136 + FMA:14283 + MA:0002902 + SCTID:24996002 aorta tunica adventitia + + + + The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers. + ISBN:0-683-40008-8 + MP:0009871 + @@ -123323,8 +190714,21 @@ + The membranous portion of the wall between the two lower chambers of the heart. + EHDAA2:0004596 + EMAPA:18246 + FMA:7135 + MA:0002939 + SCTID:278228007 + VHOG:0000927 interventricular septum membranous part + + + + The membranous portion of the wall between the two lower chambers of the heart. + MP:0008823 + @@ -123355,8 +190759,22 @@ + The muscular portion of the wall between the two lower chambers of the heart. + EHDAA2:0000885 + EHDAA:2607 + EMAPA:18247 + FMA:7134 + MA:0002940 + RETIRED_EHDAA2:0000888 interventricular septum muscular part + + + + The muscular portion of the wall between the two lower chambers of the heart. + Wikipedia:Interventricular_septum#Portions + http://orcid.org/0000-0002-6601-2165 + @@ -123376,8 +190794,28 @@ + The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane. + BAMS:RA + EMAPA:35721 + FMA:84017 + MA:0003147 + MESH:D011903 + NCIT:C97335 + NLXANAT:20090205 + TAO:0001429 + Wikipedia:Raphe_nuclei + ZFA:0001429 + neuronames:2495 + we treat NR obscurus, NR magnus etc as parts of the raphe nuclei. This is consistent with treatment in FMA, where the class is 'set of raphe nuclei' raphe nuclei + + + + The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane. + NLXANAT:20090205 + https://sourceforge.net/tracker/?func=detail&aid=3248146&group_id=36855&atid=440764 + @@ -123391,9 +190829,19 @@ - + The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]. + FMA:10636 + MA:0001939 + SCTID:244225009 + Wikipedia:Costocervical_trunk costo-cervical trunk + + + + The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]. + Wikipedia:Costocervical_trunk + @@ -123418,8 +190866,17 @@ + A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]. + EMAPA:36503 + MA:0000704 arterial system smooth muscle + + + + A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]. + OBOL:automatic + @@ -123450,8 +190907,17 @@ + A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]. + EMAPA:36613 + MA:0000715 venous system smooth muscle + + + + A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]. + OBOL:automatic + @@ -123476,8 +190942,17 @@ + An endothelium that is part of a vena cava [Automatically generated definition]. + MA:0000713 + NCIT:C49318 vena cava endothelium + + + + An endothelium that is part of a vena cava [Automatically generated definition]. + OBOL:automatic + @@ -123502,8 +190977,17 @@ + An endothelium that is part of a outflow tract [Automatically generated definition]. + MA:0000490 + VHOG:0001524 outflow tract endothelium + + + + An endothelium that is part of a outflow tract [Automatically generated definition]. + OBOL:automatic + @@ -123528,8 +191012,18 @@ + An endothelium that is part of an arterial system [Automatically generated definition]. + EMAPA:35145 + MA:0000703 + NCIT:C49329 arterial system endothelium + + + + An endothelium that is part of an arterial system [Automatically generated definition]. + OBOL:automatic + @@ -123554,8 +191048,18 @@ + An endothelium that is part of a venous system [Automatically generated definition]. + EMAPA:35907 + MA:0000714 + NCIT:C49320 venous system endothelium + + + + An endothelium that is part of a venous system [Automatically generated definition]. + OBOL:automatic + @@ -123581,8 +191085,17 @@ + A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]. + EMAPA:35732 + MA:0001805 respiratory system blood vessel endothelium + + + + A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -123596,8 +191109,24 @@ + A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches. + EHDAA2:0000197 + EHDAA:438 + EHDAA:768 + EMAPA:16333 + FMA:70300 + NCIT:C34114 + SCTID:361525002 + Wikipedia:Bulbus_cordis bulbus cordis + + + + A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches. + ISBN:0-683-40008-8 + MP:0010568 + @@ -123664,8 +191193,17 @@ + An appendage that is part of an appendage girdle complex. + VSAO:0000067 paired limb/fin + + + + An appendage that is part of an appendage girdle complex. + UBERON:cjm + https://github.com/geneontology/go-ontology/issues/9029 + @@ -123708,8 +191246,17 @@ + Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues. + VHOG:0001753 + VSAO:0000125 pectoral appendage + + + + Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues. + VSAO:0000150-modified + @@ -123723,8 +191270,24 @@ + The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava. + BTO:0001744 + CALOHA:TS-0497 + EMAPA:18638 + GAID:536 + MA:0002154 + MESH:D007601 + NCIT:C12738 + SCTID:244403000 + Wikipedia:Jugular_vein jugular vein + + + + The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava. + Wikipedia:Jugular_vein + @@ -123762,8 +191325,23 @@ + The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. + AEO:0000194 + BTO:0003834 + EHDAA2:0000001 + EHDAA2:0003235 + EMAPA:36040 + NCIT:C34131 + Wikipedia:Conceptus conceptus + + + + The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. + BTO:0003834 + Wikipedia:Conceptus + @@ -123789,8 +191367,20 @@ + A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres). + NLX:147842 + TAO:0001328 + Wikipedia:Neuromere + ZFA:0001328 neuromere + + + + A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres). + DOI:10.1016/j.tins.2013.06.004 + https://github.com/obophenotype/uberon/issues/318 + @@ -123815,8 +191405,16 @@ + Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. segmental subdivision of nervous system + + + + Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. + FBbt:00005140 + http://orcid.org/0000-0002-6601-2165 + @@ -123842,8 +191440,16 @@ + An organ subunit that is part of a hindbrain [Automatically generated definition]. + FMA:61998 segmental subdivision of hindbrain + + + + An organ subunit that is part of a hindbrain [Automatically generated definition]. + OBOL:automatic + @@ -123874,8 +191480,26 @@ + Organism at the gastrula stage. + BILA:0000060 + BTO:0001403 + FMA:293108 + GAID:1302 + MESH:D005775 + MIAA:0000179 + NCIT:C34057 + NCIT:C34058 + Wikipedia:Gastrula + Wikipedia:Trilaminar_blastocyst gastrula + + + + Organism at the gastrula stage. + Wikipedia:Gastrula + Wikipedia:Trilaminar_blastocyst + @@ -123895,8 +191519,25 @@ + A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]. + MA:0003047 + SCTID:309311006 + VSAO:0000015 + XAO:0004038 + ZFA:0005619 + Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from skeletal tissue + + + + A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000015 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/134 + @@ -123932,8 +191573,59 @@ + Dermis-derived entity that is made of skeletal tissue. dermal skeletal element + + + + Dermis-derived entity that is made of skeletal tissue. + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/206 + + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of an anal canal [Automatically generated definition]. + EMAPA:27221 + EMAPA:27233 + EMAPA:27543 + FMA:15720 + FMA:15724 + NCIT:C32068 + SCTID:245448005 + Wikipedia:Anal_gland + gland of anal canal + + + + + A gland that is part of an anal canal [Automatically generated definition]. + OBOL:automatic + Wikipedia:Anal_gland + @@ -123959,8 +191651,22 @@ + The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]. + AAO:0000094 + EHDAA:6031 + FMA:76621 + NCIT:C34121 + SCTID:155540009 + Wikipedia:Chondrocranium + XAO:0003059 cartilaginous neurocranium + + + + The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]. + Wikipedia:Chondrocranium + @@ -123997,8 +191703,18 @@ + Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. + MA:0002837 + Wikipedia:Intramembranous_ossification intramembranous bone tissue + + + + Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. + GO:0001957 + Wikipedia:Intramembranous_ossification + @@ -124012,8 +191728,21 @@ + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. + AAO:0011129 + TAO:0001890 + VSAO:0000128 + XAO:0004012 + ZFA:0005494 + galen:SkeletalStructure skeletal element + + + + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. + https://orcid.org/0000-0002-6601-2165 + @@ -124038,9 +191767,16 @@ - + A bone that is part of a cranium. + SCTID:181792001 cranial bone + + + + A bone that is part of a cranium. + UBERON:automatic + @@ -124065,8 +191801,15 @@ + Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular. bone of lower jaw + + + + Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular. + https://orcid.org/0000-0002-6601-2165 + @@ -124115,8 +191858,20 @@ + Anatomical system that consists of all the joints of the body. + EMAPA:35150 + FMA:23878 + MA:0003007 + SCTID:361827000 + VSAO:0000181 articular system + + + + Anatomical system that consists of all the joints of the body. + VSAO:0000181 + @@ -124141,8 +191896,16 @@ + A submucosa that is part of a respiratory system [Automatically generated definition]. + MA:0001822 respiratory system submucosa + + + + A submucosa that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124173,8 +191936,16 @@ + A lamina propria that is part of a respiratory system [Automatically generated definition]. + MA:0001821 respiratory system lamina propria + + + + A lamina propria that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124199,8 +191970,55 @@ + A lamina propria that is part of a gastrointestinal system. + MA:0001899 + NCIT:C49299 gastrointestinal system lamina propria + + + + A lamina propria that is part of a gastrointestinal system. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A lamina propria that is part of a gallbladder [Automatically generated definition]. + EMAPA:35371 + FMA:278594 + MA:0001633 + NCIT:C49228 + gallbladder lamina propria + + + + + A lamina propria that is part of a gallbladder [Automatically generated definition]. + OBOL:automatic + @@ -124225,8 +192043,54 @@ + A serous membrane that is part of a digestive system [Automatically generated definition]. + MA:0001522 gastrointestinal system serosa + + + + A serous membrane that is part of a digestive system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a gallbladder [Automatically generated definition]. + EMAPA:35372 + FMA:14659 + MA:0001634 + SCTID:362197006 + gallbladder serosa + + + + + A serous membrane that is part of a gallbladder [Automatically generated definition]. + OBOL:automatic + @@ -124251,8 +192115,18 @@ + An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]. + FMA:13884 + MA:0002791 + NCIT:C119295 heart ventricle wall + + + + An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]. + OBOL:automatic + @@ -124277,8 +192151,22 @@ + The mucous membrane lining the respiratory tract. + BTO:0000973 + FMA:302092 + GAID:304 + MA:0001827 + MESH:D020545 respiratory system mucosa + + + + The mucous membrane lining the respiratory tract. + MESH:A04.760 + MGI:cwg + MP:0002277 + @@ -124333,8 +192221,122 @@ + A mucosa that is part of a gastrointestinal system. + BTO:0000546 + BTO:0005568 + EMAPA:36591 + MA:0001521 + SCTID:410433007 + The gut mucosa of amphioxus has insulin-secreting cells. http://www.ncbi.nlm.nih.gov/pubmed/16417468 gastrointestinal system mucosa + + + + A mucosa that is part of a gastrointestinal system. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + A mucous gland that is part of the skin. + EMAPA:35775 + MA:0000148 + skin mucous gland + + + + + A mucous gland that is part of the skin. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + A secretion that is part of a endocrine pancreas [Automatically generated definition]. + MA:0002517 + NCIT:C33255 + secretion of endocrine pancreas + + + + + A secretion that is part of a endocrine pancreas [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A secretion that is part of a exocrine pancreas [Automatically generated definition]. + MA:0002518 + NCIT:C33256 + secretion of exocrine pancreas + + + + + A secretion that is part of a exocrine pancreas [Automatically generated definition]. + OBOL:automatic + @@ -124359,8 +192361,53 @@ + A secretion that is part of a esophagus [Automatically generated definition]. + FMA:79662 + MA:0002514 + NCIT:C52555 esophagus secretion + + + + A secretion that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A secretion that is part of a pancreas [Automatically generated definition]. + MA:0002516 + NCIT:C13270 + pancreas secretion + + + + + A secretion that is part of a pancreas [Automatically generated definition]. + OBOL:automatic + @@ -124386,8 +192433,17 @@ + Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia. + EMAPA:36296 + MA:0002854 blood vessel layer + + + + Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia. + http://orcid.org/0000-0002-6601-2165 + @@ -124420,8 +192476,22 @@ + The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi. + BTO:0000419 + CALOHA:TS-0023 + EMAPA:32827 + MA:0001480 + SCTID:321764001 respiratory tract epithelium + + + + The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi. + ISBN:0-683-40008-8 + MGI:anna + MP:0010942 + @@ -124446,8 +192516,18 @@ + An epithelium that is part of a respiratory system [Automatically generated definition]. + CALOHA:TS-0023 + EMAPA:32826 + MA:0001823 respiratory system epithelium + + + + An epithelium that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124472,8 +192552,17 @@ + An epithelium that is part of a digestive system [Automatically generated definition]. + EMAPA:32683 + MA:0001520 gastrointestinal system epithelium + + + + An epithelium that is part of a digestive system [Automatically generated definition]. + OBOL:automatic + @@ -124498,8 +192587,60 @@ + An epithelium that is part of a lower respiratory tract [Automatically generated definition]. + MA:0001481 lower respiratory tract epithelium + + + + An epithelium that is part of a lower respiratory tract [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any epithelium that lines one of the bile ducts. + BTO:0000417 + MA:0001629 + NCIT:C43616 + bile duct epithelium + + + + + Any epithelium that lines one of the bile ducts. + http://orcid.org/0000-0002-6601-2165 + @@ -124543,8 +192684,95 @@ + The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO]. + BTO:0003511 + EMAPA:35121 + FMA:63915 + MA:0001771 + NCIT:C12867 pulmonary alveolus epithelium + + + + The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO]. + BTO:0003511 + MP:0010898 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]. + EHDAA2:0000742 + EHDAA:3051 + MA:0002661 + NCIT:C43618 + extrahepatic bile duct epithelium + + + + + An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]. + EHDAA2:0000743 + EHDAA:3053 + MA:0002662 + NCIT:C43617 + intrahepatic bile duct epithelium + + + + + An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]. + OBOL:automatic + @@ -124569,8 +192797,16 @@ + A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]. + MA:0001829 respiratory system skeletal muscle + + + + A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124595,8 +192831,52 @@ + A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]. + EMAPA:36523 + MA:0001572 + Most muscle tissue lining the digestive tract is smooth, but part of the externa of the esophagus is skeletal esophagus skeletal muscle + + + + A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]. + MA:0001530 + anal region skeletal muscle + + + + + A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]. + OBOL:automatic + @@ -124621,8 +192901,51 @@ + A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]. + MA:0001578 lip skeletal muscle + + + + A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + Smooth muscle tissue in all or part of a hepatic duct. + MA:0001640 + hepatic duct smooth muscle + + + + + Smooth muscle tissue in all or part of a hepatic duct. + http://orcid.org/0000-0002-6601-2165 + @@ -124648,9 +192971,16 @@ - + An endothelium of artery that is part of a respiratory system [Automatically generated definition]. + MA:0001801 respiratory system arterial endothelium + + + + An endothelium of artery that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124676,9 +193006,16 @@ - + An endothelium of vein that is part of a respiratory system [Automatically generated definition]. + MA:0001811 respiratory system venous endothelium + + + + An endothelium of vein that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + @@ -124704,8 +193041,22 @@ + The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall. + BTO:0000394 + CALOHA:TS-0047 + EFO:0002597 + EMAPA:35134 + MA:0000701 + NCIT:C49190 aorta endothelium + + + + The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall. + MGI:csmith + MP:0009864 + @@ -124730,8 +193081,54 @@ + An endothelium that is part of the cardiovascular system. + BTO:0001853 + EMAPA:35201 + GAID:519 + MA:0000717 + MESH:D004730 + NCIT:C13053 + TAO:0002171 + VHOG:0001217 + XAO:0000356 + ZFA:0001639 cardiovascular system endothelium + + + + An endothelium that is part of the cardiovascular system. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a digestive system [Automatically generated definition]. + MA:0001900 + gastrointestinal system mesentery + + + + + A mesentery that is part of a digestive system [Automatically generated definition]. + OBOL:automatic + @@ -124756,8 +193153,16 @@ + A connective tissue that surrounds a skeletal muscle tissue. + MA:0002868 skeletal muscle connective tissue + + + + A connective tissue that surrounds a skeletal muscle tissue. + OBOL:automatic + @@ -124782,8 +193187,18 @@ + A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid. + EMAPA:35334 + MA:0000267 + Examples: harderian gland, accessory lacrimal gland, gland of Moll, gland of Zeis, nictitating membrane glands eye gland + + + + A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid. + http://orcid.org/0000-0002-6601-2165 + @@ -124808,8 +193223,18 @@ + An alveolus that is part of a right lung [Automatically generated definition]. + EMAPA:35997 + MA:0001786 + NCIT:C49278 right lung alveolus + + + + An alveolus that is part of a right lung [Automatically generated definition]. + OBOL:automatic + @@ -124834,8 +193259,18 @@ + An alveolus that is part of a left lung [Automatically generated definition]. + EMAPA:19182 + MA:0001777 + NCIT:C49251 left lung alveolus + + + + An alveolus that is part of a left lung [Automatically generated definition]. + OBOL:automatic + @@ -124861,9 +193296,55 @@ - + A vasculature that is part of a retina [Automatically generated definition]. + FMA:76552 + MESH:D012171 vasculature of retina + + + + A vasculature that is part of a retina [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye. + AAO:0000343 + FMA:84961 + SCTID:280541000 + Wikipedia:Orbit_(anatomy) + ZFA:0005558 + orbital cavity + + + + + Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye. + http://orcid.org/0000-0002-6601-2165 + @@ -124877,8 +193358,20 @@ + Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. + AAO:0011102 + BILA:0000044 + FMA:295568 + Wikipedia:Lateral_plate_mesoderm#Division_into_layers + XAO:0000276 splanchnic layer of lateral plate mesoderm + + + + Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. + Wikipedia:Lateral_plate_mesoderm#Division_into_layers + @@ -124898,8 +193391,22 @@ + A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]. + EHDAA2:0001903 + EHDAA:383 + EMAPA:16181 + FMA:295564 + NCIT:C34303 + VHOG:0000558 + Wikipedia:Splanchnopleure splanchnopleure + + + + A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]. + Wikipedia:Splanchnopleure + @@ -124919,8 +193426,22 @@ + A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]. + EHDAA2:0001847 + EHDAA:381 + EMAPA:16180 + FMA:295566 + NCIT:C34301 + VHOG:0000557 + Wikipedia:Somatopleure somatopleure + + + + A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]. + Wikipedia:Somatopleure + @@ -124940,8 +193461,19 @@ + The central region of trunk mesoderm. This tissue forms the notochord. + AAO:0000478 + EFO:0003426 + TAO:0000091 + ZFA:0000091 chordamesoderm + + + + The central region of trunk mesoderm. This tissue forms the notochord. + https://orcid.org/0000-0002-6601-2165 + @@ -124973,9 +193505,16 @@ - + The mass of tissue made up of mesenchymal cells in the lung. + EMAPA:32866 lung mesenchyme + + + + The mass of tissue made up of mesenchymal cells in the lung. + GO:0060484 + @@ -125007,8 +193546,21 @@ + A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung. + BTO:0003149 + EMAPA:35433 + MA:0000421 + NCIT:C49473 + Wikipedia:Alveolar_septum interalveolar septum + + + + A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung. + LG:0012625 + Wikipedia:Alveolar_septum + @@ -125040,8 +193592,22 @@ + A wall that contains the alveoli. + BTO:0002543 + EMAPA:35120 + FMA:14117 + MA:0002568 + NCIT:C13085 + SCTID:361965008 alveolar wall + + + + A wall that contains the alveoli. + LG:0012626 + MP:0010903 + @@ -125066,8 +193632,17 @@ + Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus. + EMAPA:35122 + MA:0002759 alveolar smooth muscle + + + + Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus. + LG:0012628 + @@ -125108,9 +193683,19 @@ - + A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila. + BTO:0000966 + EV:0100351 + TADS:0000232 + for the vertebrate-specific structure, see UBERON:0000941 (cranial nerve II) neuron projection bundle connecting eye with brain + + + + A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila. + http://orcid.org/0000-0002-6601-2165 + @@ -125124,8 +193709,15 @@ + Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts. articulation + + + + Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts. + http://orcid.org/0000-0002-6601-2165 + @@ -125149,8 +193741,48 @@ + A portion of the gut that is derived from ectoderm. ectodermal part of digestive tract + + + + A portion of the gut that is derived from ectoderm. + GO:0007439 + + + + + + + + + + + + + + + + + + + + + The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]. + FMA:49179 + NCIT:C33010 + SCTID:279973004 + Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract + galen:LowerGastrointestinalTract + lower digestive tract + + + + + The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]. + Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract + @@ -125164,8 +193796,20 @@ + The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum. + FMA:49177 + NCIT:C33837 + SCTID:181244000 + Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract + galen:UpperGastrointestinalTract upper digestive tract + + + + The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum. + Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract + @@ -125191,8 +193835,18 @@ + An epithelium surrounding a gonad. + EHDAA:4032 + EHDAA:5931 + NCIT:C32676 epithelium of gonad + + + + An epithelium surrounding a gonad. + OBOL:automatic + @@ -125217,8 +193871,205 @@ + An epithelium surrounding an ovary. + BTO:0003661 epithelium of female gonad + + + + An epithelium surrounding an ovary. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0000171 + EMAPA:16561 + EMAPA_RETIRED:16565 + VHOG:0001351 + biliary bud + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct. + CALOHA:TS-2348 + FMA:15076 + GAID:283 + MESH:D014670 + NCIT:C13011 + SCTID:362200007 + TAO:0005167 + Wikipedia:Ampulla_of_Vater + ZFA:0005167 + galen:AmpullaOfVater + hepatopancreatic ampulla + + + + + A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct. + Wikipedia:Ampulla_of_Vater + + + + + + + + + + + + + + + One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct. + EMAPA:18662 + FMA:15953 + MA:0003107 + NCIT:C119578 + SCTID:245389007 + duodenal papilla + + + + + One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct. + http://medical-dictionary.thefreedictionary.com/duodenal+papilla + + + + + + + + + + + + + + + + + + + + + + + + + + + Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]. + EMAPA:18663 + FMA:15077 + GAID:285 + MESH:D009803 + NCIT:C13065 + SCTID:181271000 + Wikipedia:Sphincter_of_ampulla + sphincter of hepatopancreatic ampulla + + + + + Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]. + Wikipedia:Sphincter_of_ampulla + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A sphincter muscle that is part of a anal region. + EMAPA:36052 + anal sphincter + + + + + A sphincter muscle that is part of a anal region. + OBOL:automatic + @@ -125249,9 +194100,16 @@ - + A proximal-distal subdivision of the digestive tract. + FMA:71131 subdivision of digestive tract + + + + A proximal-distal subdivision of the digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -125271,8 +194129,16 @@ + A part of a wall of an organ that forms a layer. + FMA:82485 organ component layer + + + + A part of a wall of an organ that forms a layer. + http://orcid.org/0000-0002-6601-2165 + @@ -125298,8 +194164,360 @@ + The tissue underlying the tunica mucosa of the pharynx. + BTO:0002113 + FMA:75144 + SCTID:19594009 submucosa of pharynx + + + + The tissue underlying the tunica mucosa of the pharynx. + BTO:0002113 + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a cystic duct [Automatically generated definition]. + FMA:18013 + submucosa of cystic duct + + + + + A submucosa that is part of a cystic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a sigmoid colon [Automatically generated definition]. + FMA:15027 + submucosa of sigmoid colon + + + + + A submucosa that is part of a sigmoid colon [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a body of stomach [Automatically generated definition]. + FMA:17059 + submucosa of body of stomach + + + + + A submucosa that is part of a body of stomach [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a pyloric antrum [Automatically generated definition]. + FMA:17060 + submucosa of pyloric antrum + + + + + A submucosa that is part of a pyloric antrum [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a pylorus [Automatically generated definition]. + EMAPA:27201 + FMA:17462 + submucosa of pylorus + + + + + A submucosa that is part of a pylorus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a biliary tree [Automatically generated definition]. + FMA:18009 + submucosa of biliary tree + + + + + A submucosa that is part of a biliary tree [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a common bile duct [Automatically generated definition]. + FMA:18011 + submucosa of common bile duct + + + + + A submucosa that is part of a common bile duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a common hepatic duct [Automatically generated definition]. + FMA:18014 + submucosa of common hepatic duct + + + + + A submucosa that is part of a common hepatic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a right hepatic duct [Automatically generated definition]. + FMA:18015 + submucosa of right hepatic duct + + + + + A submucosa that is part of a right hepatic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a left hepatic duct [Automatically generated definition]. + FMA:18017 + submucosa of left hepatic duct + + + + + A submucosa that is part of a left hepatic duct [Automatically generated definition]. + OBOL:automatic + @@ -125325,8 +194543,402 @@ + A submucosa that is part of a bronchiole [Automatically generated definition]. + FMA:62775 submucosa of bronchiole + + + + A submucosa that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a cystic duct [Automatically generated definition]. + FMA:14690 + mucosa of cystic duct + + + + + A mucosa that is part of a cystic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a sigmoid colon [Automatically generated definition]. + FMA:15026 + mucosa of sigmoid colon + + + + + A mucosa that is part of a sigmoid colon [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a body of stomach [Automatically generated definition]. + FMA:17054 + mucosa of body of stomach + + + + + A mucosa that is part of a body of stomach [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a pyloric antrum [Automatically generated definition]. + BTO:0004107 + FMA:17055 + mucosa of pyloric antrum + + + + + A mucosa that is part of a pyloric antrum [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a pylorus [Automatically generated definition]. + BTO:0004110 + EMAPA:27199 + FMA:17461 + mucosa of pylorus + + + + + A mucosa that is part of a pylorus [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a biliary tree [Automatically generated definition]. + FMA:14695 + mucosa of biliary tree + + + + + A mucosa that is part of a biliary tree [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a common bile duct [Automatically generated definition]. + FMA:14688 + mucosa of common bile duct + + + + + A mucosa that is part of a common bile duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a common hepatic duct [Automatically generated definition]. + FMA:14691 + mucosa of common hepatic duct + + + + + A mucosa that is part of a common hepatic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a right hepatic duct [Automatically generated definition]. + FMA:14692 + mucosa of right hepatic duct + + + + + A mucosa that is part of a right hepatic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a left hepatic duct [Automatically generated definition]. + FMA:14693 + mucosa of left hepatic duct + + + + + A mucosa that is part of a left hepatic duct [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a upper lip [Automatically generated definition]. + FMA:59832 + NCIT:C12224 + SCTID:362088009 + mucosa of upper lip + + + + + A mucosa that is part of a upper lip [Automatically generated definition]. + OBOL:automatic + @@ -125351,8 +194963,54 @@ + A mucosa that is part of a lower lip [Automatically generated definition]. + FMA:59833 + NCIT:C12225 + SCTID:362089001 mucosa of lower lip + + + + A mucosa that is part of a lower lip [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a gallbladder [Automatically generated definition]. + FMA:14662 + SCTID:362196002 + mucosa of gallbladder + + + + + A mucosa that is part of a gallbladder [Automatically generated definition]. + OBOL:automatic + @@ -125378,8 +195036,17 @@ + A mucosa that is part of a bronchiole [Automatically generated definition]. + FMA:62774 + SCTID:10887006 mucosa of bronchiole + + + + A mucosa that is part of a bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -125404,8 +195071,16 @@ + A mucosa that is part of a terminal bronchiole [Automatically generated definition]. + FMA:263232 mucosa of terminal bronchiole + + + + A mucosa that is part of a terminal bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -125430,8 +195105,16 @@ + A mucosa that is part of a respiratory bronchiole [Automatically generated definition]. + FMA:263238 mucosa of respiratory bronchiole + + + + A mucosa that is part of a respiratory bronchiole [Automatically generated definition]. + OBOL:automatic + @@ -125452,10 +195135,21 @@ - - + An external genitalia that is part of a female reproductive system [Automatically generated definition]. + BTO:0003100 + EMAPA:30984 + FMA:45649 + SCTID:362234008 + galen:FemaleExternalGenitalia + TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547 external female genitalia + + + + An external genitalia that is part of a female reproductive system [Automatically generated definition]. + OBOL:automatic + @@ -125480,8 +195174,15 @@ + An organ that is part of a immune system [Automatically generated definition]. immune organ + + + + An organ that is part of a immune system [Automatically generated definition]. + OBOL:automatic + @@ -125506,8 +195207,17 @@ + A gland that is part of a hemolymphoid system [Automatically generated definition]. + EMAPA:18766 + MA:0002962 hemolymphoid system gland + + + + A gland that is part of a hemolymphoid system [Automatically generated definition]. + OBOL:automatic + @@ -125521,8 +195231,25 @@ + The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. + AAO:0011071 + EMAPA:35594 + FMA:295624 + NCIT:C34224 + SCTID:361463007 + Wikipedia:Neural_groove + XAO:0000248 + neuronames:1363 neural groove + + + + The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. + GO:0001842 + Wikipedia:Neural_groove + http://orcid.org/0000-0002-6601-2165 + @@ -125546,8 +195273,90 @@ + One of the two elevated edges of the neural groove[GO,MP]. + EHDAA2:0001249 + FMA:295618 + NCIT:C34223 + SCTID:361461009 + Wikipedia:Neural_fold + XAO:0004087 + neuronames:1364 neural fold + + + + One of the two elevated edges of the neural groove[GO,MP]. + GO:0001842 + MP:0011256 + Wikipedia:Neural_fold + + + + + + + + + + + + + + + + + + + + + + + + + + Missing definition for term UBERON:0005064. Please replace it using linked reference. + left ventricular trabecular myocardium + + + + + Missing definition for term UBERON:0005064. Please replace it using linked reference. + GO:0003225 + + + + + + + + + + + + + + + + + + + + + + + + + + Missing definition for term UBERON:0005066. Please replace it using linked reference. + right ventricular trabecular myocardium + + + + + Missing definition for term UBERON:0005066. Please replace it using linked reference. + GO:0003227 + @@ -125561,8 +195370,19 @@ + A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]. + EFO:0003498 + TAO:0000133 + ZFA:0000133 neural rod + + + + A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]. + GO:0014024 + ZFA:0000133 + @@ -125604,8 +195424,15 @@ + An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord. hindbrain-spinal cord boundary + + + + An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord. + OBOL:automatic + @@ -125630,8 +195457,18 @@ + A hole in a tube[GO]. + AEO:0000078 + EHDAA2:0004618 + RETIRED_EHDAA2:0003078 tube lumen + + + + A hole in a tube[GO]. + GO:0060609 + @@ -125646,8 +195483,16 @@ + An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]. + AEO:0000218 ectodermal placode + + + + An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]. + GO:0060788 + @@ -125667,8 +195512,16 @@ + Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. + FMA:30316 muscle structure + + + + Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. + GO:0061061 + @@ -125682,6 +195535,11 @@ + EHDAA2:0001841 + EHDAA:484 + EMAPA:16239 + FMA:70318 + VHOG:0000489 right horn of sinus venosus @@ -125691,8 +195549,16 @@ + A bud is a protrusion that forms from an epithelial sheet by localized folding. + BTO:0001639 epithelial bud + + + + A bud is a protrusion that forms from an epithelial sheet by localized folding. + GO:0060572 + @@ -125717,8 +195583,15 @@ + Any anatomical structure that is part of the reproductive system. reproductive structure + + + + Any anatomical structure that is part of the reproductive system. + http://orcid.org/0000-0002-6601-2165 + @@ -125726,8 +195599,15 @@ + An epithelial sheet bent on a linear axis. epithelial fold + + + + An epithelial sheet bent on a linear axis. + GO:0060571 + @@ -125753,8 +195633,16 @@ + The functional tissue of the central nervous system consisting of neurons and glial cells. parenchyma of central nervous system + + + + The functional tissue of the central nervous system consisting of neurons and glial cells. + CL:tm + https://github.com/obophenotype/uberon/issues/8 + @@ -125768,8 +195656,18 @@ + A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. + AAO:0011000 + CARO:0001000 + FMA:83115 multi cell part structure + + + + A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. + CARO:0001000 + @@ -125777,9 +195675,54 @@ - + Connective tissue between the cellular elements of a structure. + FMA:86301 + SCTID:85293002 interstitial tissue + + + + Connective tissue between the cellular elements of a structure. + http://medical-dictionary.thefreedictionary.com/tissue + + + + + + + + + + + + + + + + + + + + + Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion). + EHDAA2:0000741 + EHDAA:3049 + EMAPA:16843 + FMA:71891 + MA:0000357 + NCIT:C32730 + SCTID:245399002 + VHOG:0000219 + galen:HepaticDuct + hepatic duct + + + + + Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion). + http://orcid.org/0000-0002-6601-2165 + @@ -125804,8 +195747,17 @@ + An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland. + MA:0000522 + SCTID:272631008 abdomen element + + + + An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland. + http://orcid.org/0000-0002-6601-2165 + @@ -125830,8 +195782,16 @@ + An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region. + MA:0000529 abdominal segment element + + + + An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region. + http://orcid.org/0000-0002-6601-2165 + @@ -125856,8 +195816,16 @@ + An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back. + MA:0001901 dorsal region element + + + + An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back. + http://orcid.org/0000-0002-6601-2165 + @@ -125882,8 +195850,16 @@ + An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. + MA:0000516 trunk region element + + + + An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. + http://orcid.org/0000-0002-6601-2165 + @@ -125909,8 +195885,16 @@ + An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. + MA:0000557 thoracic cavity element + + + + An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. + http://orcid.org/0000-0002-6601-2165 + @@ -125935,8 +195919,16 @@ + An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. + MA:0000563 thoracic segment organ + + + + An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. + http://orcid.org/0000-0002-6601-2165 + @@ -125956,8 +195948,175 @@ + A vein that is part of a thorax [Automatically generated definition]. + MA:0002235 + NCIT:C53142 + SCTID:281472008 thoracic vein + + + + A vein that is part of a thorax [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen. + EMAPA:36574 + FMA:7473 + MA:0002937 + SCTID:197423006 + trachea gland + + + + + A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen. + ISBN:1451113412 + MGI:Anna + PMID:15973734 + http://medical-dictionary.thefreedictionary.com/tracheal+glands + https://github.com/obophenotype/uberon/issues/1197 + + + + + + + + + + + + + + + + + + + + + + + + + + A parenchyma that is part of a right lobe of liver [Automatically generated definition]. + EHDAA2:0001010 + EMAPA:18317 + FMA:71657 + VHOG:0000840 + liver right lobe parenchyma + + + + + A parenchyma that is part of a right lobe of liver [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A parenchyma that is part of a left lobe of liver [Automatically generated definition]. + EHDAA2:0001002 + EMAPA:18310 + FMA:71658 + VHOG:0000839 + liver left lobe parenchyma + + + + + A parenchyma that is part of a left lobe of liver [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An ectoderm that is part of a medial nasal prominence [Automatically generated definition]. + EHDAA2:0001078 + EMAPA:16809 + FMA:312675 + VHOG:0000803 + medial-nasal process ectoderm + + + + + An ectoderm that is part of a medial nasal prominence [Automatically generated definition]. + OBOL:automatic + @@ -125982,8 +196141,19 @@ + An ectoderm that is part of a optic eminence [Automatically generated definition]. + EHDAA:940 + EMAPA:16539 + RETIRED_EHDAA2:0001309 + VHOG:0001105 optic eminence ectoderm + + + + An ectoderm that is part of a optic eminence [Automatically generated definition]. + OBOL:automatic + @@ -125991,6 +196161,9 @@ + EHDAA2:0001154 + EMAPA:17078 + VHOG:0000320 basal plate metencephalon @@ -126017,8 +196190,19 @@ + An endocardium that is part of a interventricular septum [Automatically generated definition]. + EHDAA2:0000886 + EHDAA2:0000887 + FMA:83584 + VHOG:0000615 interventricular septum endocardium + + + + An endocardium that is part of a interventricular septum [Automatically generated definition]. + OBOL:automatic + @@ -126043,8 +196227,17 @@ + A myocardium that is part of a bulbus cordis [Automatically generated definition]. + EMAPA:36488 + VHOG:0000609 bulbus cordis myocardium + + + + A myocardium that is part of a bulbus cordis [Automatically generated definition]. + OBOL:automatic + @@ -126069,8 +196262,16 @@ + A gland that is part of a stomodeum. + VHOG:0000658 stomatodeum gland + + + + A gland that is part of a stomodeum. + OBOL:automatic + @@ -126097,8 +196298,18 @@ + An anatomical cavity that is part of a yolk sac [Automatically generated definition]. + EMAPA:16055 + FMA:63942 + VHOG:0000843 yolk sac cavity + + + + An anatomical cavity that is part of a yolk sac [Automatically generated definition]. + OBOL:automatic + @@ -126130,8 +196341,25 @@ + Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. + EFO:0003492 + EHDAA2:0000732 + EHDAA:179 + EMAPA:16098 + EMAPA_RETIRED:16269 + FMA:76622 + TAO:0000113 + VHOG:0000332 + ZFA:0000113 head mesenchyme + + + + Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. + ISBN:0683400088 + MP:0011260 + @@ -126167,8 +196395,22 @@ + Mesenchyme that is part of a developing trunk. + EFO:0003485 + EHDAA2:0002092 + EHDAA:377 + EMAPA:16177 + TAO:0000081 + VHOG:0000281 + ZFA:0000081 trunk mesenchyme + + + + Mesenchyme that is part of a developing trunk. + OBOL:automatic + @@ -126182,8 +196424,27 @@ + The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. + BTO:0000758 + CALOHA:TS-0607 + CALOHA:TS-2365 + DHBA:10662 + EHDAA2:0001207 + EHDAA:5526 + EMAPA:17082 + HBA:9512 + MA:0000205 + VHOG:0000456 + Wikipedia:Myelencephalon myelencephalon + + + + The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. + BTO:0000758 + Wikipedia:Myelencephalon + @@ -126208,8 +196469,16 @@ + A portion of tissue that is part of an embryo. + CALOHA:TS-2100 embryonic tissue + + + + A portion of tissue that is part of an embryo. + OBOL:automatic + @@ -126234,8 +196503,20 @@ + Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo. + BTO:0003360 + CALOHA:TS-2119 + EFO:0001406 + MAT:0000061 + MIAA:0000061 extraembryonic tissue + + + + Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo. + https://orcid.org/0000-0002-6601-2165 + @@ -126260,8 +196541,16 @@ + The endothelial lining of the endocardium. + FMA:83596 endocardial endothelium + + + + The endothelial lining of the endocardium. + UBERON:cjm + @@ -126286,8 +196575,16 @@ + An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]. + BTO:0000137 pulmonary artery endothelium + + + + An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]. + GO:0061155 + @@ -126312,8 +196609,16 @@ + A lamina propria that is part of a mucosa of oral region. + EMAPA:26947 oral lamina propria + + + + A lamina propria that is part of a mucosa of oral region. + OBOL:automatic + @@ -126338,8 +196643,18 @@ + A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]. + FMA:13225 + Wikipedia:Ventricular_outflow_tract + XAO:0004140 outflow tract of ventricle + + + + A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]. + Wikipedia:Ventricular_outflow_tract + @@ -126364,8 +196679,19 @@ + An outflow tract that is part of a aorta. + EHDAA2:0001353 + EMAPA:17329 + MA:0000101 + VHOG:0001394 outflow tract aortic component + + + + An outflow tract that is part of a aorta. + OBOL:automatic + @@ -126373,6 +196699,11 @@ + EHDAA2:0001359 + EHDAA:4401 + EMAPA:17330 + MA:0000102 + VHOG:0001395 outflow tract pulmonary component @@ -126415,8 +196746,15 @@ + An array of photoreceptors and any supporting cells found in an eye. photoreceptor array + + + + An array of photoreceptors and any supporting cells found in an eye. + https://orcid.org/0000-0002-6601-2165 + @@ -126436,8 +196774,15 @@ + A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array. transparent eye structure + + + + A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array. + http://orcid.org/0000-0002-6601-2165 + @@ -126445,8 +196790,36 @@ + One of: the common carotid artery, or its branches, the external and internal carotid arteries. + AAO:0010217 + BTO:0000168 + CALOHA:TS-0116 + EFO:0000818 + EHDAA:6385 + EMAPA:18609 + EV:0100379 + FMA:70504 + GAID:478 + MA:0001925 + MAT:0000501 + MESH:D002339 + NCIT:C12687 + SCTID:362040006 + SCTID:69105007 + TAO:0000097 + VHOG:0000266 + Wikipedia:Carotid_artery + ZFA:0000097 + galen:CarotidArtery carotid artery segment + + + + One of: the common carotid artery, or its branches, the external and internal carotid arteries. + Wikipedia:Carotid_artery + https://sourceforge.net/tracker/?func=detail&aid=3486870&group_id=76834&atid=994764 + @@ -126471,8 +196844,17 @@ + A sex gland that is part of a female reproductive system. + BTO:0000254 + MA:0000383 female reproductive gland + + + + A sex gland that is part of a female reproductive system. + OBOL:automatic + @@ -126492,8 +196874,28 @@ + The part of the digestive system that excludes the hepatobiliary system. + BTO:0000058 + CALOHA:TS-0407 + EHDAA2:0000110 + EHDAA:514 + EMAPA:16246 + FMA:71132 + GAID:294 + MA:0000323 + MESH:D041981 + NCIT:C12378 + SCTID:373871007 + VHOG:0000412 + galen:GastrointestinalTract alimentary part of gastrointestinal system + + + + The part of the digestive system that excludes the hepatobiliary system. + http://orcid.org/0000-0002-6601-2165 + @@ -126530,8 +196932,21 @@ + A limb bud that develops into a forelimb or pectoral fin. + EFO:0003430 + TAO:0000141 + VHOG:0001754 + VHOG_RETIRED:0001259 + ZFA:0000141 + at this time we have no need to name a more specific 'pectoral fin bud' class, but we may in future pectoral appendage bud + + + + A limb bud that develops into a forelimb or pectoral fin. + OBOL:automatic + @@ -126562,8 +196977,22 @@ + An apical ectodermal ridge that is part of a pectoral appendage bud. + EFO:0003487 + EHDAA2:0000138 + EMAPA:16778 + TAO:0000085 + TAO:0000736 + VHOG:0001064 + ZFA:0000085 pectoral appendage apical ectodermal ridge + + + + An apical ectodermal ridge that is part of a pectoral appendage bud. + OBOL:automatic + @@ -126577,9 +197006,11 @@ - - - + AEO:0000125 + CALOHA:TS-2122 + EHDAA2:0003125 + FMA:292313 + MIAA:0000019 developing anatomical structure @@ -126613,8 +197044,20 @@ + Portion of tissue that is the inner layer of the optic cup and will become the neural retina. + EHDAA2:0001304 + EMAPA:16675 + TAO:0001071 + VHOG:0000490 + ZFA:0001071 presumptive neural retina + + + + Portion of tissue that is the inner layer of the optic cup and will become the neural retina. + ZFIN:curator + @@ -126629,8 +197072,23 @@ + Portion of tissue that gives rise to the lens. + EHDAA2:0000983 + EHDAA:4737 + EMAPA:17163 + SCTID:361510002 + TAO:0002205 + VHOG:0001163 + ZFA:0001679 lens vesicle + + + + Portion of tissue that gives rise to the lens. + ZFIN:curator + https://sourceforge.net/tracker/?func=detail&atid=994726&aid=3514998&group_id=76834 + @@ -126647,8 +197105,17 @@ + Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea. + TAO:0002188 + ZFA:0001688 corneal primordium + + + + Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea. + ZFIN:ZDB-PUB-061010-3 + @@ -126663,8 +197130,21 @@ + Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]. + EHDAA2:0002156 + EHDAA:669 + TAO:0000818 + VHOG:0001208 + XAO:0004191 + ZFA:0000818 vagal neural crest + + + + Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]. + ZFIN:curator + @@ -126686,8 +197166,21 @@ + The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates. + EHDAA2:0004145 + EHDAA:9826 + EMAPA:36461 + FMA:71008 + RETIRED_EHDAA2:0000133 + SCTID:361527005 aortic sac + + + + The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates. + MP:0012510 + @@ -126707,11 +197200,94 @@ + FMA:24219 + SCTID:123958008 cervical region + + + + + + + + + + + In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:. + EHDAA2:0000308 + EHDAA:8570 + FMA:14771 + MA:0003094 + SCTID:244263001 + Wikipedia:Common_hepatic_artery + galen:CommonHepaticArtery + common hepatic artery + + + + + In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:. + Wikipedia:Common_hepatic_artery + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa. + AAO:0000194 + EHDAA2:0000552 + EHDAA:10629 + EMAPA:18712 + FMA:53154 + SCTID:369439002 + VHOG:0001543 + Wikipedia:Foramen_rotundum + foramen rotundum + + + + + The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa. + Wikipedia:Foramen_rotundum + + + + @@ -126734,8 +197310,20 @@ + A vitelline vein that is in the left side of a multicellular organism. + EHDAA2:0000971 + EMAPA:16380 + EMAPA:16698 + FMA:70307 + SCTID:361446008 left vitelline vein + + + + A vitelline vein that is in the left side of a multicellular organism. + OBOL:automatic + @@ -126761,8 +197349,20 @@ + A vitelline vein that is in the right side of a multicellular organism. + EHDAA2:0001766 + EMAPA:16381 + EMAPA:16699 + FMA:70306 + SCTID:361445007 right vitelline vein + + + + A vitelline vein that is in the right side of a multicellular organism. + OBOL:automatic + @@ -126776,8 +197376,19 @@ + A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]. + BAMS:slim + BAMS:slm + neuronames:629 sulcus limitans of neural tube + + + + A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]. + http://medical-dictionary.thefreedictionary.com/Sulcus+limitans + http://www.ncbi.nlm.nih.gov/books/NBK10047 + @@ -126803,8 +197414,26 @@ + The paired veins that carry blood from the yolk sac back to the embryo. + EMAPA:36021 + FMA:70305 + NCIT:C34329 + RETIRED_EHDAA2:0002209 + SCTID:2730004 + SCTID:308832003 + VHOG:0000401 + Wikipedia:Vitelline_veins + XAO:0000376 + XAO:0004147 vitelline vein + + + + The paired veins that carry blood from the yolk sac back to the embryo. + MGI:csmith + MP:0010666 + @@ -126818,8 +197447,22 @@ + Portion of tissue on the side of the lumen of the neural tube. + EHDAA2:0001257 + EHDAA:2873 + EHDAA:912 + EMAPA:16166 + TAO:0001435 + VHOG:0000513 + ZFA:0001435 neural tube lateral wall + + + + Portion of tissue on the side of the lumen of the neural tube. + ZFA:0001435 + @@ -126828,6 +197471,15 @@ + EFO:0003643 + EHDAA:257 + EMAPA:16074 + RETIRED_EHDAA2:0001273 + TAO:0001178 + VHOG:0001372 + XAO:0004091 + ZFA:0001178 + Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998). non-neural ectoderm @@ -126850,8 +197502,24 @@ + Multi-tissue structure that arises from the heart rudiment and will become the heart tube. + EHDAA2:0001512 + EHDAA:424 + EHDAA:436 + EMAPA:16215 + FMA:321916 + SCTID:361522004 + TAO:0000149 + Wikipedia:Primitive_heart_tube + ZFA:0000149 primitive heart tube + + + + Multi-tissue structure that arises from the heart rudiment and will become the heart tube. + ZFA:0000149 + @@ -126876,8 +197544,17 @@ + A neural tube lateral wall that is part of a rhombomere. + EMAPA:32819 + EMAPA:35364 rhombomere lateral wall + + + + A neural tube lateral wall that is part of a rhombomere. + OBOL:automatic + @@ -126893,8 +197570,22 @@ + Cranial neural crest which gives rise to the trigeminal ganglion. + EFO:0003484 + EHDAA2:0002083 + EHDAA:667 + EMAPA:16170 + TAO:0000080 + VHOG:0000269 + ZFA:0000080 trigeminal neural crest + + + + Cranial neural crest which gives rise to the trigeminal ganglion. + ZFA:0000080 + @@ -126914,8 +197605,22 @@ + Portion of tissue that gives rise to the immature gonad. + EFO:0003651 + EHDAA:5927 + EMAPA:17204 + RETIRED_EHDAA2:0002148 + TAO:0001262 + WBbt:0008366 + ZFA:0001262 gonad primordium + + + + Portion of tissue that gives rise to the immature gonad. + ZFA:0001262 + @@ -126948,8 +197653,18 @@ + Somite located in the head region, caudal to the otic vesicle. + EHDAA2:0003437 + EMAPA:16172 + XAO:0000313 head somite + + + + Somite located in the head region, caudal to the otic vesicle. + PMID:11830559 + @@ -126975,8 +197690,19 @@ + A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum. + AAO:0011059 + EFO:0002578 + EMAPA:36007 + XAO:0001002 lung primordium + + + + A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum. + XAO:0001002 + @@ -127001,8 +197727,78 @@ + A somite that is part of a trunk. + AAO:0010385 + EHDAA2:0003438 + EMAPA:16184 + XAO:0000314 trunk somite + + + + A somite that is part of a trunk. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum. + EHDAA2:0000416 + EHDAA:3001 + EMAPA:17025 + MA:0001618 + NCIT:C34142 + VHOG:0000352 + Wikipedia:Dorsal_mesentery + dorsal mesogastrium + + + + + The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum. + Wikipedia:Dorsal_mesentery + + + + + + + + + + + + + + + + + + + + + EMAPA:16844 + MA:0001636 + VHOG:0000215 + extrahepatic part of hepatic duct + @@ -127017,6 +197813,12 @@ + EHDAA2:0000936 + EHDAA:404 + EMAPA:16205 + MA:0000478 + SCTID:361403005 + VHOG:0000484 left dorsal aorta @@ -127053,8 +197855,113 @@ + A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex. + EHDAA2:0000984 + EHDAA:9059 + EMAPA:17304 + EMAPA:17839 + FMA:70612 + MA:0001302 + NCIT:C33641 + RETIRED_EHDAA2:0000976 + SCTID:362521008 + VHOG:0001425 lens anterior epithelium + + + + A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Arteries which arise from the abdominal aorta and distribute to most of the intestines. + BTO:0000779 + EHDAA2:0001123 + EHDAA:4343 + EMAPA:17312 + MA:0002003 + MESH:D008638 + NCIT:C52975 + SCTID:281084003 + VHOG:0001117 + Wikipedia:Mesenteric_artery + XAO:0000370 + mesenteric artery + + + + + Arteries which arise from the abdominal aorta and distribute to most of the intestines. + MESH:A07.231.114.565 + Wikipedia:Mesenteric_artery + + + + + + + + + + + + + + + + + + + + + + + + + + A vein that returns blood from the intestines. + BTO:0002781 + EHDAA:4442 + EMAPA:17348 + MA:0002177 + MESH:D008642 + NCIT:C53055 + RETIRED_EHDAA2:0001125 + SCTID:304045008 + Wikipedia:Mesenteric_vein + mesenteric vein + + + + + A vein that returns blood from the intestines. + MESH:A07.231.908.670.385 + Wikipedia:Mesenteric_vein + @@ -127069,6 +197976,12 @@ + EHDAA2:0001720 + EHDAA:406 + EMAPA:16206 + MA:0000479 + SCTID:361404004 + VHOG:0000485 right dorsal aorta @@ -127084,8 +197997,54 @@ + Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo. + EHDAA2:0004714 + FMA:305915 + SCTID:362840007 extraembryonic membrane + + + + Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo. + ISBN:0073040584 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a pylorus. + EHDAA2:0001582 + EMAPA:17633 + RETIRED_EHDAA2:0001927 + pyloric region epithelium + + + + + An epithelium that is part of a pylorus. + OBOL:automatic + @@ -127110,8 +198069,16 @@ + An epithelium that is part of a anterior chamber of eyeball. + EHDAA2:0000130 anterior chamber epithelium + + + + An epithelium that is part of a anterior chamber of eyeball. + OBOL:automatic + @@ -127136,8 +198103,18 @@ + An epithelium that is part of a lens vesicle. + EHDAA2:0000987 + EMAPA:17165 + VHOG:0000532 lens vesicle epithelium + + + + An epithelium that is part of a lens vesicle. + OBOL:automatic + @@ -127162,8 +198139,21 @@ + An ectoderm that is part of a pharyngeal arch 4. + EHDAA2:0004032 + EMAPA:16762 + EMAPA:16764 + EMAPA:16768 + RETIRED_EHDAA2:0000094 + VHOG:0001095 4th arch ectoderm + + + + An ectoderm that is part of a pharyngeal arch 4. + OBOL:automatic + @@ -127188,8 +198178,21 @@ + An endoderm that is part of a pharyngeal arch 4. + EHDAA2:0004033 + EMAPA:16765 + EMAPA:16767 + EMAPA:16769 + RETIRED_EHDAA2:0000095 + VHOG:0001092 4th arch endoderm + + + + An endoderm that is part of a pharyngeal arch 4. + OBOL:automatic + @@ -127214,8 +198217,20 @@ + A mesothelium that is part of a peritoneal cavity. + BTO:0003156 + EHDAA2:0001447 + EMAPA:16139 + FMA:18147 + SCTID:34073007 peritoneal cavity mesothelium + + + + A mesothelium that is part of a peritoneal cavity. + OBOL:automatic + @@ -127236,8 +198251,16 @@ + An endothelium that is part of a right lung. + EHDAA2:0001755 right lung endothelium + + + + An endothelium that is part of a right lung. + OBOL:automatic + @@ -127258,8 +198281,54 @@ + An endothelium that is part of a left lung. + EHDAA2:0000961 left lung endothelium + + + + An endothelium that is part of a left lung. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A dorsal mesentery that is part of a midgut. + EMAPA:16722 + EMAPA:17040 + EMAPA:18671 + RETIRED_EHDAA2:0001187 + SCTID:361434009 + midgut dorsal mesentery + + + + + A dorsal mesentery that is part of a midgut. + OBOL:automatic + @@ -127290,8 +198359,18 @@ + An anatomical cavity that is part of a lens vesicle. + EHDAA2:0000986 + EMAPA:17164 + VHOG:0000531 lens vesicle cavity + + + + An anatomical cavity that is part of a lens vesicle. + OBOL:automatic + @@ -127316,8 +198395,20 @@ + Mesenchyme that is part of a pharyngeal arch 4. + EHDAA2:0000096 + EHDAA:1677 + EMAPA:16770 + FMA:295702 + VHOG:0001052 4th arch mesenchyme + + + + Mesenchyme that is part of a pharyngeal arch 4. + OBOL:automatic + @@ -127343,8 +198434,96 @@ + Mesenchyme that is part of a optic eminence. + EHDAA:942 + EMAPA:16324 + RETIRED_EHDAA2:0001310 + VHOG:0001073 optic eminence mesenchyme + + + + Mesenchyme that is part of a optic eminence. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery of duodenum that is part of a foregut. + EHDAA2:0000564 + foregut duodenum mesentery + + + + + A mesentery of duodenum that is part of a foregut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery of duodenum that is part of a midgut. + EHDAA2:0001193 + midgut duodenum mesentery + + + + + A mesentery of duodenum that is part of a midgut. + OBOL:automatic + @@ -127370,8 +198549,18 @@ + A venous system that is part of a hindbrain. + EHDAA2:0000776 + EMAPA:18632 + VHOG:0001322 hindbrain venous system + + + + A venous system that is part of a hindbrain. + OBOL:automatic + @@ -127396,6 +198585,7 @@ + BILA:0000139 chemosensory system @@ -127419,6 +198609,11 @@ + EHDAA2:0000474 + EMAPA:31862 + EMAPA:31863 + FMA:296719 + VHOG:0000616 extraembryonic mesoderm @@ -127446,8 +198641,17 @@ + A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme. + TAO:0001453 + ZFA:0001453 pectoral appendage field + + + + A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme. + OBOL:automatic + @@ -127481,8 +198685,15 @@ + A ring of cells capable of forming a limb or paired fin[Gilbert,modified]. paired limb/fin field + + + + A ring of cells capable of forming a limb or paired fin[Gilbert,modified]. + ISBN:9780878932504 + @@ -127503,8 +198714,21 @@ + The outermost layer of a blood vessel, composed mainly of fibrous tissue. + BTO:0002010 + EMAPA:36299 + NCIT:C33818 + SCTID:61066005 + Wikipedia:Tunica_externa_(vessels) tunica adventitia of blood vessel + + + + The outermost layer of a blood vessel, composed mainly of fibrous tissue. + ISBN:0073040584 + Wikipedia:Tunica_externa_(vessels) + @@ -127530,8 +198754,20 @@ + A tunica intima that is part of a artery. + EMAPA:36293 + EV:0100028 + FMA:14272 + SCTID:40022005 + galen:IntimaOfArtery tunica intima of artery + + + + A tunica intima that is part of a artery. + OBOL:automatic + @@ -127545,9 +198781,19 @@ - + An outermost connective tissue covering of an organ, vessel, or other structure[WP]. + BTO:0002010 + FMA:45635 + SCTID:30180000 + Wikipedia:Adventitia adventitia + + + + An outermost connective tissue covering of an organ, vessel, or other structure[WP]. + Wikipedia:Adventitia + @@ -127572,8 +198818,19 @@ + Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves. + AAO:0010438 + TAO:0001736 + VHOG:0001760 + ZFA:0005386 bone foramen + + + + Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves. + TAO:curator + @@ -127598,11 +198855,16 @@ - - - + An acellular anatomical structure that is the bounding layer of a anatomical structure. + FMA:63871 acellular membrane + + + + An acellular anatomical structure that is the bounding layer of a anatomical structure. + OBOL:automatic + @@ -127640,8 +198902,22 @@ + An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. + AAO:0010596 + FMA:63872 + GAID:915 + NCIT:C13191 + SCTID:68989006 + Wikipedia:Basement_membrane basement membrane of epithelium + + + + An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. + Wikipedia:Basement_membrane + http://orcid.org/0000-0002-6601-2165 + @@ -127656,8 +198932,18 @@ + Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle. + FMA:13087 + NCIT:C34027 + SCTID:119203005 section of aorta + + + + Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle. + ncithesaurus:Aortic_Segment + @@ -127684,8 +198970,47 @@ + The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. + AAO:0011029 + BTO:0004673 + EHDAA:402 + EMAPA:18606 + SCTID:338637006 + TAO:0000014 + VHOG:0000264 + Wikipedia:Dorsal_aorta + XAO:0000051 + ZFA:0000014 dorsal aorta + + + + The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. + GO:0035907 + https://sourceforge.net/p/geneontology/ontology-requests/8525/ + + + + + + + + + In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]. + FMA:45628 + MESH:D011168 + NCIT:C33344 + SCTID:362063001 + Wikipedia:Portal_venous_system + portal system + + + + + In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]. + Wikipedia:Portal_venous_system + @@ -127693,11 +199018,53 @@ + BIRNLEX:2665 + FMA:62420 + MA:0003080 + SCTID:278748001 spinal cord segment + + + + + + + + + + + + + + + + + + + + + + A spinal cord segment that adjacent_to a caudal region. + FMA:256635 + MA:0003084 + SCTID:278753006 + neuronames:1656 + for spinal cord segments, we treat coccygeal/caudal as synonyms - we only differentiate where bone is concerned + caudal segment of spinal cord + + + + + A spinal cord segment that adjacent_to a caudal region. + OBOL:automatic + + + + @@ -127709,8 +199076,18 @@ + A delimited region of dense mesenchyme within looser mesenchyme. + AEO:0000148 + EHDAA2_RETIRED:0003148 + EHDAA:8979 developing mesenchymal condensation + + + + A delimited region of dense mesenchyme within looser mesenchyme. + AEO:0000148 + @@ -127730,8 +199107,20 @@ + Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes. + AEO:0000147 + EHDAA2_RETIRED:0003147 + EMAPA:32731 + VSAO:0000092 + XAO:0004022 cartilaginous condensation + + + + Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes. + GO:curator + @@ -127768,6 +199157,8 @@ + AEO:0000149 + EHDAA2_RETIRED:0003149 pre-muscle condensation @@ -127790,8 +199181,19 @@ + A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts. + AEO:0000150 + EHDAA2:0003150 + EMAPA:32736 pre-cartilage condensation + + + + A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts. + AEO:0000150 + AEO:JB + @@ -127811,8 +199213,52 @@ + The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip. + EHDAA2:0001061 + EHDAA:5871 + EMAPA:17355 + FMA:293051 + NCIT:C34204 + Wikipedia:Mandibular_prominence mandibular prominence + + + + The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip. + ISBN:0-683-40008-8 + MP:0010939 + + + + + + + + + + + + + + + The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw. + EHDAA2:0001070 + EHDAA:5877 + EMAPA:17359 + FMA:293049 + NCIT:C34206 + SCTID:346355001 + Wikipedia:Maxillary_prominence + maxillary prominence + + + + + The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw. + ISBN:0-683-40008-8 + MP:0010940 + @@ -127826,8 +199272,24 @@ + Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles. + AAO:0010199 + BTO:0004675 + FMA:49187 + SCTID:362618001 + TAO:0001414 + XAO:0003173 + ZFA:0001414 + neuronames:2431 occipital region + + + + Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles. + TAO:0001414 + UBERONREF:0000007 + @@ -127847,8 +199309,19 @@ + Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]. + FMA:9689 + SCTID:362890006 + See notes for serous membrane serous sac + + + + Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]. + FMA:9689 + https://github.com/obophenotype/uberon/issues/86 + @@ -127868,8 +199341,16 @@ + Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]. + FMA:69065 endo-epithelium + + + + Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]. + FMA:69065 + @@ -127895,9 +199376,46 @@ - + Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. + AAO:0000963 + EMAPA:17214 + MA:0000308 + NCIT:C32172 + SCTID:361725000 + VSAO:0000056 + Wikipedia:Axial_skeleton + XAO:0004011 axial skeleton plus cranial skeleton + + + + Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. + FMA:71221 + VSAO:0000056 + Wikipedia:Axial_skeleton + https://github.com/obophenotype/uberon/issues/44 + https://github.com/obophenotype/uberon/wiki/The-axial-skeleton + + + + + + + + + + + + + + + + EFO:0003677 + TAO:0001321 + ZFA:0001321 + neurocranial trabecula + @@ -127928,8 +199446,16 @@ + An outflow tract that is part of a cardiac atrium. + FMA:14141 outflow tract of atrium + + + + An outflow tract that is part of a cardiac atrium. + OBOL:automatic + @@ -127966,8 +199492,18 @@ + Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk. + FMA:7216 + NCIT:C61368 + SCTID:244379003 outflow part of right ventricle + + + + Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk. + MP:0010428 + @@ -127992,8 +199528,18 @@ + Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta. + FMA:9473 + SCTID:264070001 + Wikipedia:Aortic_vestibule outflow part of left ventricle + + + + Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta. + MP:0010429 + @@ -128018,8 +199564,17 @@ + Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA]. + FMA:9550 outflow part of right atrium + + + + Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA]. + FMA:9550 + FMA:FMA + @@ -128044,8 +199599,16 @@ + An outflow tract of atrium that is part of a left atrium. + FMA:9551 outflow part of left atrium + + + + An outflow tract of atrium that is part of a left atrium. + OBOL:automatic + @@ -128066,8 +199629,18 @@ + The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium. + FMA:9236 + SCTID:277693004 + Wikipedia:Crista_terminalis crista terminalis + + + + The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium. + MP:0010495 + @@ -128099,8 +199672,15 @@ + The laminar structure of the heart. heart layer + + + + The laminar structure of the heart. + MP:0010545 + @@ -128132,8 +199712,65 @@ + Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation. + MESH:D003331 + Wikipedia:Coronary_circulation coronary vessel + + + + Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation. + MP:0010551 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The supporting bundles of muscular fibers lining the walls of the atrial myocardium. + ZFA:0005810 + atrium myocardial trabecula + + + + + The supporting bundles of muscular fibers lining the walls of the atrial myocardium. + MP:0010581 + ZFA:0005810 + @@ -128175,8 +199812,18 @@ + The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve. + FMA:7136 + SCTID:280151006 + Wikipedia:Atrioventricular_septum atrioventricular septum + + + + The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve. + MP:0010592 + @@ -128208,8 +199855,20 @@ + The paired arteries that carry blood to the yolk sac from the dorsal aorta. + EHDAA2:0002208 + EMAPA:16207 + Wikipedia:Vitelline_arteries + Development notes:; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult[MP:0010664] vitelline artery + + + + The paired arteries that carry blood to the yolk sac from the dorsal aorta. + MP:0010664 + Wikipedia:Vitelline_arteries + @@ -128223,8 +199882,17 @@ + Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. + Wikipedia:Skin_appendage integumentary adnexa + + + + Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. + http://code.google.com/p/caro2/issues/detail?id=5 + http://orcid.org/0000-0002-6601-2165 + @@ -128260,6 +199928,276 @@ + + + + + + + + + + + + + + + + + + + + + + A bone that is part of a post-anal tail. + EMAPA:18042 + MA:0000696 + bone of tail + + + + + A bone that is part of a post-anal tail. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this. + XAO:0000087 + caudal region + + + + + Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + That portion of the spine comprising the cervical vertebrae. The neck area of the spine. + AAO:0000092 + BTO:0004148 + EHDAA2:0000238 + EHDAA:5051 + EMAPA:17215 + FMA:24138 + MA:0003154 + NCIT:C69313 + SCTID:260488005 + cervical region of vertebral column + + + + + That portion of the spine comprising the cervical vertebrae. The neck area of the spine. + http://medical-dictionary.thefreedictionary.com/ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + That part of the spine comprising the thoracic vertebrae. + BTO:0004150 + EHDAA:5063 + EMAPA:17396 + FMA:9140 + MA:0003155 + NCIT:C69315 + SCTID:243931006 + thoracic region of vertebral column + + + + + That part of the spine comprising the thoracic vertebrae. + http://medical-dictionary.thefreedictionary.com/ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae. + AAO:0000082 + EMAPA:18043 + MA:0003158 + caudal region of vertebral column + + + + + Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae. + UBERONREF:0000006 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A collection of all skeletal elements in some subdivision of the vertebral column. + FMA:16201 + subdivision of vertebral column + + + + + A collection of all skeletal elements in some subdivision of the vertebral column. + https://orcid.org/0000-0002-6601-2165 + + + + @@ -128298,8 +200236,22 @@ + The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions. + CALOHA:TS-2409 + EHDAA2:0000136 + EHDAA:2592 + EMAPA:16827 + VHOG:0000502 + Wikipedia:Aorticopulmonary_septum aortico-pulmonary spiral septum + + + + The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions. + MP:0010650 + Wikipedia:Aorticopulmonary_septum + @@ -128343,8 +200295,22 @@ + The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx. + EHDAA2:0000189 + EHDAA:536 + EMAPA:16259 + FMA:313607 + SCTID:361412007 + VHOG:0000380 + Wikipedia:Buccopharyngeal_membrane buccopharyngeal membrane + + + + The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx. + MP:0012521 + @@ -128358,11 +200324,145 @@ + EHDAA:1267 + EMAPA:16342 + RETIRED_EHDAA2:0000268 common atrial chamber + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0000456 + EHDAA:8363 + EMAPA:18023 + FMA:312597 + ethmoid bone primordium + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical junctions that overlaps the foregut and midgut. + EHDAA2:0000569 + EHDAA:526 + EMAPA:16363 + VHOG:0000291 + foregut-midgut junction + + + + + An anatomical junctions that overlaps the foregut and midgut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0000577 + EHDAA:9540 + EMAPA:18017 + FMA:312589 + tetrapod frontal bone primordium + + + + @@ -128379,8 +200479,25 @@ + The embryonic precursor of the brain. + BAMS:Enc + BTO:0004726 + EFO:0003431 + EHDAA:300 + EHDAA:830 + EMAPA:16089 + FMA:312967 + RETIRED_EHDAA2:0000591 + TAO:0000146 + ZFA:0000146 future brain + + + + The embryonic precursor of the brain. + NLX:94995 + @@ -128419,8 +200536,18 @@ + A tendon that has the potential to develop into a central tendon. + EHDAA2:0000593 + EHDAA:4118 + EMAPA:25035 future central tendon + + + + A tendon that has the potential to develop into a central tendon. + OBOL:automatic + @@ -128446,11 +200573,69 @@ + EFO:0003438 + EHDAA2:0000674 + EHDAA:898 + EMAPA:16092 + EMAPA:16755 + TAO:0000417 + ZFA:0000417 future spinal cord + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops. + EHDAA2:0000700 + EHDAA:3047 + EMAPA:16713 + XAO:0004205 + gallbladder primordium + + + + + A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops. + ISBN:0815318960 + XAO:0004205 + + + + @@ -128488,8 +200673,19 @@ + An anatomical junctions that overlaps the mouth and foregut. + EHDAA:534 + EMAPA:16258 + RETIRED_EHDAA2:0001205 + VHOG:0000592 mouth-foregut junction + + + + An anatomical junctions that overlaps the mouth and foregut. + OBOL:automatic + @@ -128506,8 +200702,20 @@ + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. + EHDAA2:0001278 + EHDAA:264 + EMAPA:16101 + NCIT:C34231 + VHOG:0001212 notochordal plate + + + + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. + VHOG:0001212 + @@ -128527,8 +200735,60 @@ + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. + EHDAA2:0001279 + EHDAA:224 + EMAPA:16102 + FMA:293135 + NCIT:C34232 + VHOG:0001213 + The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. notochordal process + + + + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. + http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/05embryonicperiod.htm + + + + + + + + + + + + + + + + + + + + + + + + + + + Either of two openings transmitting nerves and blood vessels to or from the orbit. + EHDAA2:0001328 + EHDAA:10648 + EMAPA:18717 + SCTID:280546005 + orbital fissure + + + + + Either of two openings transmitting nerves and blood vessels to or from the orbit. + http://www.merriam-webster.com/medical/orbital%20fissure + @@ -128576,8 +200836,21 @@ + Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity. + EHDAA2:0001481 + EHDAA:4128 + EMAPA:17707 + SCTID:361413002 + VHOG:0001505 pleuroperitoneal canal + + + + Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity. + ISBN:0124020607 + VHOG:0001505 + @@ -128603,8 +200876,61 @@ + Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle. + EHDAA2:0001531 + EMAPA:16350 + FMA:71006 + NCIT:C34160 + SCTID:361524003 + TAO:0002231 + Wikipedia:Embryonic_ventricle + ZFA:0001719 + The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum[WP] future cardiac ventricle + + + + Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle. + ZFA:0001719 + + + + + + + + + + + + + + + + + + + + + + + + + A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]. + EHDAA2:0001904 + EHDAA:3003 + EMAPA:18535 + XAO:0000326 + spleen primordium + + + + + A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]. + ISBN:0123747295 + MP:0011263 + @@ -128630,6 +200956,10 @@ + EHDAA:924 + EMAPA:16663 + RETIRED_EHDAA2:0002089 + See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/13 and https://github.com/obophenotype/uberon/issues/693 -- consider merging into trigeminal ganglion, as this complicates the model future trigeminal ganglion @@ -128667,8 +200997,20 @@ + A segment of the eyeball that is filled with refractive media. + BTO:0002085 + FMA:58071 + MA:0002459 + NCIT:C32301 + SCTID:280540004 chamber of eyeball + + + + A segment of the eyeball that is filled with refractive media. + http://orcid.org/0000-0002-6601-2165 + @@ -128682,8 +201024,16 @@ + Body substance in a liquid or semi-solid state in the eyeball which serves to refract light. + MA:0001911 ocular refractive media + + + + Body substance in a liquid or semi-solid state in the eyeball which serves to refract light. + http://orcid.org/0000-0002-6601-2165 + @@ -128708,8 +201058,22 @@ + Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. + BIRNLEX:20 + FMA:280556 + GAID:266 + MESH:D001826 + Wikipedia:Body_fluid + galen:BodyFluid bodily fluid + + + + Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. + MESH:A12.207 + Wikipedia:Body_fluid + @@ -128734,8 +201098,17 @@ + A nucleus of brain that is part of a brainstem. + EMAPA:32790 + MA:0000821 brainstem nucleus + + + + A nucleus of brain that is part of a brainstem. + OBOL:automatic + @@ -128761,8 +201134,19 @@ + An artery that connects two larger arteries. + EMAPA:18598 + MA:0001938 + NCIT:C52851 + Grouping for anterior and posterior communicating artery + + + + An artery that connects two larger arteries. + ncithesaurus:Communicating_Artery + @@ -128787,8 +201171,19 @@ + A lobe of lung that is part of a right lung. + EMAPA:35155 + MA:0001791 + NCIT:C48944 + SCTID:272654004 right lung lobe + + + + A lobe of lung that is part of a right lung. + OBOL:automatic + @@ -128809,8 +201204,19 @@ + System pertaining to a bronchus and alveoli. + BTO:0000136 + CALOHA:TS-1296 + EMAPA:32692 + MA:0000416 alveolar system + + + + System pertaining to a bronchus and alveoli. + BTO:0000136 + @@ -128831,6 +201237,8 @@ + EMAPA:19001 + MA:0001775 left lung alveolar system @@ -128853,6 +201261,8 @@ + EMAPA:35717 + MA:0001784 right lung alveolar system @@ -128879,8 +201289,16 @@ + A portion of organism substance that secreted_by a zone of skin. + MA:0002537 skin secretion + + + + A portion of organism substance that secreted_by a zone of skin. + OBOL:automatic + @@ -128905,8 +201323,16 @@ + A portion of organism substance that is secreted by a female reproductive gland. + MA:0002510 female reproductive gland secretion + + + + A portion of organism substance that is secreted by a female reproductive gland. + UBERON:cjm + @@ -128931,8 +201357,51 @@ + A portion of organism substance that secreted_by a respiratory system. + EMAPA:36550 + MA:0002533 + NCIT:C13722 respiratory system fluid/secretion + + + + A portion of organism substance that secreted_by a respiratory system. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A tube that is part of a excretory system. + excretory tube + + + + + A tube that is part of a excretory system. + OBOL:automatic + @@ -128946,8 +201415,18 @@ + The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. + MAT:0000049 + MESH:D010614 + MIAA:0000049 pharynx + + + + The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. + GO:0060465 + @@ -128972,8 +201451,17 @@ + Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA]. + FMA:85030 tunica media of pulmonary trunk + + + + Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA]. + FMA:85030 + FMA:FMA + @@ -129004,9 +201492,18 @@ - + A myocardium that is part of a left ventricle of a heart. + FMA:9558 + MA:0002983 + SCTID:362021000 left ventricle myocardium + + + + A myocardium that is part of a left ventricle of a heart. + http://orcid.org/0000-0002-6601-2165 + @@ -129037,9 +201534,143 @@ - + A myocardium that is part of a right ventricle of a heart. + FMA:9535 + MA:0002984 + SCTID:362020004 right ventricle myocardium + + + + A myocardium that is part of a right ventricle of a heart. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + A trabecula carnea that is part of a heart right ventricle. + FMA:7270 + SCTID:192373001 + trabecula carnea of right ventricle + + + + + A trabecula carnea that is part of a heart right ventricle. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A trabecula carnea that is part of a heart left ventricle. + FMA:7271 + SCTID:190344008 + trabecula carnea of left ventricle + + + + + A trabecula carnea that is part of a heart left ventricle. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:. + EMAPA:19159 + FMA:75383 + NCIT:C34245 + SCTID:245445008 + Wikipedia:Pectinate_line + pectinate line + + + + + The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:. + Wikipedia:Pectinate_line + @@ -129080,8 +201711,19 @@ + Presumptive structure of the blastula that will develop into endoderm. + AAO:0000471 + EFO:0003437 + TAO:0000416 + ZFA:0000416 presumptive endoderm + + + + Presumptive structure of the blastula that will develop into endoderm. + http://orcid.org/0000-0002-6601-2165 + @@ -129106,6 +201748,10 @@ + AAO:0000468 + EFO:0003439 + TAO:0000568 + ZFA:0000568 presumptive blood @@ -129136,8 +201782,20 @@ + Portion of embryonic tissue determined by fate mapping to become a structure. + AAO:0000479 + TAO:0001116 + ZFA:0001116 presumptive structure + + + + Portion of embryonic tissue determined by fate mapping to become a structure. + GOC:CVS + GOC:YMB + ZFA:0001116 + @@ -129178,8 +201836,20 @@ + Presumptive structure of the blastula that will develop into ectoderm. + AAO:0000470 + EFO:0003466 + TAO:0001376 + XAO:0004132 + ZFA:0001376 presumptive ectoderm + + + + Presumptive structure of the blastula that will develop into ectoderm. + http://orcid.org/0000-0002-6601-2165 + @@ -129220,8 +201890,50 @@ + Presumptive structure of the blastula that will develop into mesoderm. + AAO:0000476 + EFO:0003467 + TAO:0001377 + ZFA:0001377 presumptive mesoderm + + + + Presumptive structure of the blastula that will develop into mesoderm. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis. + BTO:0004838 + SCTID:86915006 + Wikipedia:Muscular_layer + muscular coat + + + + + A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis. + Wikipedia:Muscular_layer + @@ -129249,8 +201961,22 @@ + The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers. + EMAPA:17702 + FMA:58279 + NCIT:C34119 + SCTID:244943002 + VHOG:0001399 + Wikipedia:Central_tendon_of_diaphragm central tendon of diaphragm + + + + The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers. + MGI:csmith + MP:0012061 + @@ -129275,8 +202001,54 @@ + An anatomical boundary that adjacent_to a epithelium. + FMA:70997 surface of epithelium + + + + An anatomical boundary that adjacent_to a epithelium. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A vein that is part of a vertebral column. + EMAPA:18255 + FMA:76735 + MA:0002108 + SCTID:181376008 + Wikipedia:Spinal_veins + spinal vein + + + + + A vein that is part of a vertebral column. + OBOL:automatic + @@ -129318,9 +202090,23 @@ - + The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm. + EFO:0001403 + FMA:58342 + GAID:896 + MESH:D016850 + SCTID:63716004 + Wikipedia:Corneal_limbus + ZFA:0005570 + This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343 corneo-scleral junction + + + + The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm. + MP:0013477 + @@ -129345,8 +202131,18 @@ + An epithelium that is composed primarily of secretory cells. + BTO:0002991 + NCIT:C43370 + NCIT:C45715 glandular epithelium + + + + An epithelium that is composed primarily of secretory cells. + http://orcid.org/0000-0002-6601-2165 + @@ -129372,8 +202168,51 @@ + Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand. + AAO:0000027 + FMA:63897 + SCTID:68477002 areolar connective tissue + + + + Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand. + FMA:63897 + + + + + + + + + + + + + + + + + + + + + + + + + + The supporting bundles of muscular fibers lining the walls of the atria[MP]. + trabecula carnea of atrium + + + + + The supporting bundles of muscular fibers lining the walls of the atria[MP]. + MP:0010581 + @@ -129404,8 +202243,17 @@ + An anatomical space that surrounded_by a trachea. + FMA:7469 + SCTID:197486000 lumen of trachea + + + + An anatomical space that surrounded_by a trachea. + OBOL:automatic + @@ -129443,8 +202291,46 @@ + A subdivision of a the reproductive tract in a female organism that is the site of embryo development. + TADS:0000421 + WBbt:0006760 uterus or analog + + + + A subdivision of a the reproductive tract in a female organism that is the site of embryo development. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + Vein that is central to a lobule in the liver. + FMA:17544 + NCIT:C32281 + SCTID:272023004 + TAO:0005168 + Wikipedia:Central_veins_of_liver + ZFA:0005168 + central vein of liver + + + + + Vein that is central to a lobule in the liver. + ZFA:0005168 + @@ -129458,8 +202344,49 @@ + A furrow or an incomplete tube. + AEO:0000161 + EHDAA2_RETIRED:0003161 + Surface groove is modelled as immaterial - see https://github.com/obophenotype/uberon/issues/2667 for discussion surface groove + + + + A furrow or an incomplete tube. + AEO:0000161 + AEO:JB + https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/4 + + + + + + + + + + + + + + + + + + + + + The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus. + WBbt:0005773 + terminal part of digestive tract + + + + + The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus. + http://orcid.org/0000-0002-6601-2165 + @@ -129484,8 +202411,53 @@ + A vasculature that is part of a organ. + FMA:74612 vasculature of organ + + + + A vasculature that is part of a organ. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A vasculature that is part of a liver. + EHDAA2:0003454 + EMAPA:35501 + FMA:73748 + vasculature of liver + + + + + A vasculature that is part of a liver. + OBOL:automatic + @@ -129511,8 +202483,27 @@ + A head mesenchyme that develops_from a mesoderm. + AAO:0011051 + EFO:0003337 + EFO:0003603 + EHDAA2:0001118 + EHDAA:655 + EMAPA:16099 + EMAPA_RETIRED:16270 + FMA:293859 + TAO:0000998 + VHOG:0000185 + XAO:0000053 + ZFA:0000998 head mesenchyme from mesoderm + + + + A head mesenchyme that develops_from a mesoderm. + OBOL:automatic + @@ -129537,8 +202528,19 @@ + Mesenchyme that is part of a mandibular prominence. + EHDAA2:0001062 + EHDAA:5861 + EHDAA:5873 + EMAPA:17357 mandibular process mesenchyme + + + + Mesenchyme that is part of a mandibular prominence. + OBOL:automatic + @@ -129569,8 +202571,18 @@ + An anatomical space that surrounded_by a digestive tract. + BTO:0000349 + EMAPA:32908 + FMA:45677 lumen of digestive tract + + + + An anatomical space that surrounded_by a digestive tract. + OBOL:automatic + @@ -129595,8 +202607,18 @@ + An epithelium that is part of a lip. + BTO:0004468 + TAO:0005334 + ZFA:0005334 lip epithelium + + + + An epithelium that is part of a lip. + OBOL:automatic + @@ -129621,8 +202643,19 @@ + An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. + BTO:0002072 + NCIT:C12848 + SCTID:40118003 + Wikipedia:Squamous_epithelium squamous epithelium + + + + An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. + Wikipedia:Squamous_epithelium + @@ -129642,8 +202675,19 @@ + Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]. + FMA:45563 + NCIT:C13180 + Wikipedia:Stratified_squamous_epithelium stratified squamous epithelium + + + + Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]. + FMA:45563 + Wikipedia:Stratified_squamous_epithelium + @@ -129663,8 +202707,20 @@ + A squamous epithelium that is part of a esophagus. + BTO:0003635 + CALOHA:TS-1250 + EMAPA:35324 + MA:0001567 + NCIT:C49222 esophagus squamous epithelium + + + + A squamous epithelium that is part of a esophagus. + OBOL:automatic + @@ -129684,8 +202740,17 @@ + A squamous epithelium that is part of a stomach. + EMAPA:35824 + MA:0001611 stomach squamous epithelium + + + + A squamous epithelium that is part of a stomach. + OBOL:automatic + @@ -129717,8 +202782,18 @@ + A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands. + EMAPA:35814 + FMA:63458 + MA:0002784 stomach glandular epithelium + + + + A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands. + ISBN:0073040584 + @@ -129738,8 +202813,17 @@ + Any gland that is part of the digestive system. + AAO:0000130 + BTO:0000345 digestive system gland + + + + Any gland that is part of the digestive system. + UBERON:cjm + @@ -129759,8 +202843,17 @@ + Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]. + FMA:64800 + NCIT:C13182 glandular columnar epithelium + + + + Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]. + FMA:64800 + @@ -129780,6 +202873,7 @@ + FMA:66809 glandular cuboidal epithelium @@ -129806,8 +202900,17 @@ + Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region. + EMAPA:27167 + MA:0001614 stomach glandular region mucosa + + + + Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region. + http://orcid.org/0000-0002-6601-2165 + @@ -129838,8 +202941,18 @@ + Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue. + CALOHA:TS-0682 + FMA:62410 + SCTID:309045006 sensory epithelium + + + + Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue. + BTO:0000314 + @@ -129871,9 +202984,22 @@ - + The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis. + CALOHA:TS-1246 + EMAPA:28880 + FMA:18626 + MA:0002991 + NCIT:C33638 + SCTID:259306002 + Wikipedia:Stroma_of_ovary ovary stroma + + + + The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis. + Wikipedia:Stroma_of_ovary + @@ -129905,8 +203031,19 @@ + The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]. + EFO:0003709 + TAO:0005077 + ZFA:0005077 vascular cord + + + + The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]. + GO:0072360 + ZFA:0005077 + @@ -129926,8 +203063,16 @@ + A capillary that is part of the coronary system. + ZFA:0005813 coronary capillary + + + + A capillary that is part of the coronary system. + http://orcid.org/0000-0002-6601-2165 + @@ -129935,8 +203080,21 @@ + A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n. + BILA:0000010 + CARO:0001002 + EHDAA2_RETIRED:0003192 + FMA:24137 + NCIT:C34022 + Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism. anatomical surface + + + + A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n. + CARO:0001002 + @@ -129969,8 +203127,26 @@ + The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. + AAO:0011021 + BILA:0000051 + EFO:0000315 + EHDAA2:0000214 + EHDAA:385 + FMA:293143 + SCTID:360387000 + VHOG:0001641 + XAO:0000235 cardiogenic splanchnic mesoderm + + + + The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. + XAO:0000235 + http://www.drugs.com/dict/cardiogenic-mesoderm.html + https://github.com/obophenotype/insect_neuroanatomy_ontology/issues/7 + @@ -130005,8 +203181,16 @@ + Organism at the cleavage stage. + BILA:0000058 cleaving embryo + + + + Organism at the cleavage stage. + OBOL:automatic + @@ -130049,6 +203233,9 @@ + BILA:0000084 + NCIT:C34268 + SCTID:360394002 presumptive gut @@ -130075,6 +203262,7 @@ + BILA:0000142 mechanosensory system @@ -130090,8 +203278,18 @@ + Cranial neural crest that migrates into the mandibular arch. + TAO:0007064 + XAO:0000024 + ZFA:0007064 mandibular neural crest + + + + Cranial neural crest that migrates into the mandibular arch. + ZFA:0007064 + @@ -130122,8 +203320,18 @@ + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. + TADS:0000147 + http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg + Gene notes: Bmp, Nkx, Gata primary circulatory organ + + + + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. + GO:0007507 + @@ -130148,8 +203356,20 @@ + Ganglion which is located in the trunk. + EFO:0000901 + MAT:0000344 + MIAA:0000344 + TAO:0001573 + ZFA:0001573 trunk ganglion + + + + Ganglion which is located in the trunk. + ZFIN:curator + @@ -130163,8 +203383,244 @@ + An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. + EFO:0003497 + TAO:0000131 + ZFA:0000131 neural keel + + + + An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. + ZFIN:ZDB-PUB-961014-576 + + + + + + + + + + + + + + + An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail. + EMAPA:16748 + FMA:85540 + embryonic post-anal tail + + + + + An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that surrounded_by a midgut. + EMAPA:18377 + FMA:54366 + lumen of midgut + + + + + An anatomical cavity that surrounded_by a midgut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that surrounded_by a hindgut. + EMAPA:18396 + FMA:54367 + lumen of hindgut + + + + + An anatomical cavity that surrounded_by a hindgut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that surrounded_by a anal canal. + EMAPA:18836 + FMA:17357 + lumen of anal canal + + + + + An anatomical cavity that surrounded_by a anal canal. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that surrounded_by a colon. + EMAPA:18945 + FMA:18374 + SCTID:362156004 + lumen of colon + + + + + An anatomical cavity that surrounded_by a colon. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A lamina propria that is part of a colonic mucosa. + EMAPA:27395 + FMA:15657 + MA:0003196 + SCTID:113284008 + lamina propria of mucosa of colon + + + + + A lamina propria that is part of a colonic mucosa. + OBOL:automatic + @@ -130189,8 +203645,19 @@ + A mesothelium that is part of a serous pericardium. + BTO:0003157 + EMAPA:16133 + FMA:18149 + SCTID:67300002 mesothelium of serous pericardium + + + + A mesothelium that is part of a serous pericardium. + OBOL:automatic + @@ -130234,8 +203701,18 @@ + The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis. + CALOHA:TS-0085 + FMA:21426 + Wikipedia:Bone_marrow#Stroma stroma of bone marrow + + + + The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis. + Wikipedia:Bone_marrow#Stroma + @@ -130268,9 +203745,19 @@ - + The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells. + FMA:7393 + NCIT:C117875 + SCTID:361384001 + Wikipedia:Tracheobronchial_tree tracheobronchial tree + + + + The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells. + Wikipedia:Tracheobronchial_tree + @@ -130278,8 +203765,15 @@ + The vasculature consisting of brachiocephalic arteries and veins. brachiocephalic vasculature + + + + The vasculature consisting of brachiocephalic arteries and veins. + http://orcid.org/0000-0002-6601-2165 + @@ -130305,8 +203799,22 @@ + Mesenchyme that develops_from a cranial neural crest. + EFO:0003572 + EHDAA2:0000735 + EMAPA:16169 + EMAPA:16271 + EMAPA_RETIRED:16271 + TAO:0000787 + ZFA:0000787 mesenchyme derived from head neural crest + + + + Mesenchyme that develops_from a cranial neural crest. + OBOL:automatic + @@ -130332,8 +203840,19 @@ + Mesenchyme that develops_from a trunk neural crest. + EHDAA2:0002093 + EMAPA:16182 + TAO:0000999 + ZFA:0000999 mesenchyme derived from trunk neural crest + + + + Mesenchyme that develops_from a trunk neural crest. + OBOL:automatic + @@ -130347,11 +203866,33 @@ + EHDAA2:0000031 + EHDAA:583 + EMAPA:16382 + VHOG:0000510 1st arch mandibular component + + + + + + + + + + + EHDAA2:0000038 + EHDAA:595 + EMAPA:16388 + 1st arch maxillary component + + + + @@ -130373,8 +203914,20 @@ + A tunica media that is part of a artery. + EMAPA:36294 + EV:0100029 + FMA:14273 + NCIT:C49321 + SCTID:84300001 tunica media of artery + + + + A tunica media that is part of a artery. + OBOL:automatic + @@ -130405,8 +203958,19 @@ + A tunica adventitia that is part of a artery. + EMAPA:36295 + EV:0100030 + FMA:14274 + SCTID:113261001 tunica adventitia of artery + + + + A tunica adventitia that is part of a artery. + OBOL:automatic + @@ -130431,8 +203995,19 @@ + A tunica adventitia that is part of a vein. + EMAPA:36310 + EV:0100034 + FMA:14355 + SCTID:13202006 tunica adventitia of vein + + + + A tunica adventitia that is part of a vein. + OBOL:automatic + @@ -130458,8 +204033,19 @@ + A tunica intima that is part of a vein. + EMAPA:36308 + EV:0100032 + FMA:14353 + SCTID:2436009 tunica intima of vein + + + + A tunica intima that is part of a vein. + OBOL:automatic + @@ -130484,8 +204070,19 @@ + A tunica media that is part of a vein. + EMAPA:36309 + EV:0100033 + FMA:14354 + SCTID:42049001 tunica media of vein + + + + A tunica media that is part of a vein. + OBOL:automatic + @@ -130510,8 +204107,17 @@ + Gray matter of the central nervous system which is a collection of clustered nuclei. + FMA:256381 + FMA:84059 nuclear complex of neuraxis + + + + Gray matter of the central nervous system which is a collection of clustered nuclei. + http://orcid.org/0000-0002-6601-2165 + @@ -130537,8 +204143,17 @@ + Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei. + FMA:72246 + SCTID:369024009 nucleus of superior olivary complex + + + + Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei. + http://orcid.org/0000-0002-6601-2165 + @@ -130564,8 +204179,17 @@ + A pre-cartilage condensation that is part of a trachea. + EHDAA2:0002070 + EHDAA:7082 trachea pre-cartilage rings + + + + A pre-cartilage condensation that is part of a trachea. + OBOL:automatic + @@ -130591,8 +204215,18 @@ + Any collection of muscles that is part of a pectoral appendage. + EFO:0003540 + TAO:0000563 + ZFA:0000563 pectoral appendage musculature + + + + Any collection of muscles that is part of a pectoral appendage. + OBOL:automatic + @@ -130617,8 +204251,17 @@ + Any collection of muscles that is part of an appendage. + TAO:0000207 + ZFA:0000207 appendage musculature + + + + Any collection of muscles that is part of an appendage. + OBOL:automatic + @@ -130655,8 +204298,17 @@ + Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle. + VSAO:0005000 pectoral appendage skeleton + + + + Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle. + VSAO:0005000 + VSAO:NI + @@ -130699,8 +204351,23 @@ + The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. + BAMS:HB + CALOHA:TS-2118 + EFO:0003440 + EHDAA2:0001630 + FMA:295640 + TAO:0000569 + Wikipedia:Rhombencephalon + ZFA:0000569 presumptive hindbrain + + + + The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. + Wikipedia:Rhombencephalon + @@ -130731,8 +204398,17 @@ + Portion of tissue that is part of the heart tube and will become the sinus venosus. + TAO:0002234 + ZFA:0001722 presumptive sinus venosus + + + + Portion of tissue that is part of the heart tube and will become the sinus venosus. + ZFA:0001722 + @@ -130769,8 +204445,17 @@ + A presumptive structure that has the potential to develop into a endocardium. + TAO:0002233 + ZFA:0001724 presumptive endocardium + + + + A presumptive structure that has the potential to develop into a endocardium. + OBOL:automatic + @@ -130801,8 +204486,19 @@ + Embryonic structure that gives rise to the midbrain hindbrain boundary. + EFO:0003446 + TAO:0001187 + XAO:0004086 + ZFA:0001187 presumptive midbrain hindbrain boundary + + + + Embryonic structure that gives rise to the midbrain hindbrain boundary. + ZFA:0001187 + @@ -130833,8 +204529,18 @@ + A presumptive structure that has the potential to develop into a presomitic mesoderm. + EFO:0003421 + TAO:0000053 + ZFA:0000053 presumptive segmental plate + + + + A presumptive structure that has the potential to develop into a presomitic mesoderm. + OBOL:automatic + @@ -130871,8 +204577,18 @@ + A presumptive structure that has the potential to develop into a neural plate. + EFO:0003424 + TAO:0000063 + ZFA:0000063 presumptive neural plate + + + + A presumptive structure that has the potential to develop into a neural plate. + OBOL:automatic + @@ -130892,8 +204608,20 @@ + The part of the blastula that has the potential to develop into a paraxial mesoderm. + EFO:0003443 + TAO:0000591 + XAO:0004134 + ZFA:0000591 presumptive paraxial mesoderm + + + + The part of the blastula that has the potential to develop into a paraxial mesoderm. + UBERON:cjm + https://github.com/obophenotype/uberon/issues/1277 + @@ -130918,8 +204646,17 @@ + A blood vessel that is part of a pectoral appendage. + TAO:0005301 + ZFA:0005301 pectoral appendage blood vessel + + + + A blood vessel that is part of a pectoral appendage. + OBOL:automatic + @@ -130944,8 +204681,17 @@ + A blood vessel that is part of a limb/fin. + TAO:0005299 + ZFA:0005299 appendage blood vessel + + + + A blood vessel that is part of a limb/fin. + OBOL:automatic + @@ -130970,8 +204716,17 @@ + A vasculature that is part of a pectoral appendage. + TAO:0005096 + ZFA:0005096 pectoral appendage vasculature + + + + A vasculature that is part of a pectoral appendage. + OBOL:automatic + @@ -130996,8 +204751,17 @@ + A vasculature that is part of a chordate pharynx. + TAO:0005003 + ZFA:0005003 pharyngeal vasculature + + + + A vasculature that is part of a chordate pharynx. + OBOL:automatic + @@ -131022,8 +204786,149 @@ + A vasculature that is part of a limb/fin. + TAO:0005095 + ZFA:0005095 appendage vasculature + + + + A vasculature that is part of a limb/fin. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans. + FMA:16012 + MA:0000721 + pancreatic lobule + + + + + A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans. + ISBN:0123813611 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A duct that collects and carries secretions of the exocrine pancreas to the intestine. + EHDAA:9194 + EMAPA:32952 + FMA:10419 + MA:0000124 + SCTID:181278006 + TAO:0001372 + VHOG:0000254 + Wikipedia:Pancreatic_duct + ZFA:0001372 + pancreatic duct + + + + + A duct that collects and carries secretions of the exocrine pancreas to the intestine. + GOC:cvs + GOC:ymb + Wikipedia:Pancreatic_duct + https://github.com/obophenotype/uberon/issues/1250 + https://orcid.org/0000-0002-2244-7917 + https://orcid.org/0000-0002-6601-2165 + https://orcid.org/0000-0002-9900-7880 + + + + + + + + + + + + + + + A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones. + CALOHA:TS-2212 + Wikipedia:Palate + roof of mouth + + + + + A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones. + https://orcid.org/0000-0002-6601-2165 + @@ -131065,8 +204970,21 @@ + The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. + BSA:0000073 + BTO:0000313 + HAO:0000298 + TADS:0000109 + WBbt:0005733 + Wikipedia:Epidermis_(zoology) outer epithelium + + + + The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. + GO:0008544 + @@ -131088,8 +205006,18 @@ + Outermost layer of cells surrounding the embryo. + EFO:0003425 + TAO:0000086 + ZFA:0000086 enveloping layer of ectoderm + + + + Outermost layer of cells surrounding the embryo. + http://orcid.org/0000-0002-6601-2165 + @@ -131120,8 +205048,17 @@ + A cartilage tissue that is part of a paired limb or fin. + TAO:0001543 + ZFA:0001543 paired limb/fin cartilage + + + + A cartilage tissue that is part of a paired limb or fin. + http://orcid.org/0000-0002-6601-2165 + @@ -131153,8 +205090,17 @@ + A cartilage tissue that is part of a pectoral appendage. + TAO:0000257 + ZFA:0000257 pectoral appendage cartilage tissue + + + + A cartilage tissue that is part of a pectoral appendage. + OBOL:automatic + @@ -131179,8 +205125,17 @@ + A nucleus of brain that spans a midbrain tegmentum. + FMA:258768 + ZFA:0005577 nucleus of midbrain tegmentum + + + + A nucleus of brain that spans a midbrain tegmentum. + OBOL:automatic + @@ -131205,8 +205160,16 @@ + The space within an epithelial sphere. + AEO:0000079 lumen of epithelial sac + + + + The space within an epithelial sphere. + AEO:JB + @@ -131231,8 +205194,17 @@ + A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified. + AEO:0000081 + EHDAA2:0003081 matrix-based tissue + + + + A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified. + AEO:JB + @@ -131252,8 +205224,18 @@ + An epithelial tube that is open at one end only. + AEO:0000115 + EHDAA2:0003115 epithelial sac + + + + An epithelial tube that is open at one end only. + AEO:JB + UBERONREF:0000001 + @@ -131261,8 +205243,18 @@ + An epithelial tube open at both ends that allows fluid flow. + AEO_RETIRED:0000116 + RETIRED_EHDAA2:0003116 epithelial tube open at both ends + + + + An epithelial tube open at both ends that allows fluid flow. + AEO:JB + UBERONREF:0000001 + @@ -131270,8 +205262,100 @@ + A closed epithelium with a lumen. + AEO:0000119 + EHDAA2:0003119 epithelial vesicle + + + + A closed epithelium with a lumen. + AEO:JB + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A ring of smooth muscle cells whose contraction closes the opening of the ring. + AEO:0000143 + EHDAA2:0003143 + SCTID:362915001 + smooth muscle sphincter + + + + + A ring of smooth muscle cells whose contraction closes the opening of the ring. + AEO:JB + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A ring of striated muscle cells whose contraction closes the opening of the ring. + AEO:0000144 + EHDAA2:0003144 + striated muscle sphincter + + + + + A ring of striated muscle cells whose contraction closes the opening of the ring. + AEO:JB + @@ -131285,8 +205369,17 @@ + Mesenchyme with little extracellular matrix. + AEO:0000146 + EHDAA2:0003146 dense mesenchyme tissue + + + + Mesenchyme with little extracellular matrix. + AEO:JB + @@ -131311,8 +205404,17 @@ + Mesenchymal cells that are migrating. + AEO:0000152 + EHDAA2:0003152 migrating mesenchyme population + + + + Mesenchymal cells that are migrating. + AEO:JB + @@ -131332,8 +205434,16 @@ + Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]. + FMA:64798 ciliated columnar epithelium + + + + Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]. + FMA:64798 + @@ -131358,8 +205468,15 @@ + Epithelium bearing vibratile cilia on the free surface. ciliated epithelium + + + + Epithelium bearing vibratile cilia on the free surface. + http://medical-dictionary.thefreedictionary.com/ciliated+epithelium + @@ -131390,8 +205507,19 @@ + A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. + BTO:0001338 + CALOHA:TS-0998 + FMA:66762 layer of synovial tissue + + + + A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. + BTO:0001338 + http://www.britannica.com/EBchecked/topic/578563/synovial-tissue + @@ -131416,8 +205544,16 @@ + An anatomical cavity that surrounded_by a synovial joint. + FMA:11356 synovial cavity of joint + + + + An anatomical cavity that surrounded_by a synovial joint. + OBOL:automatic + @@ -131442,8 +205578,17 @@ + Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules. + GAID:907 + MESH:D010857 pigment epithelium of eye + + + + Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules. + MP:0005200 + @@ -131469,8 +205614,17 @@ + A neural nucleus that is part of a medulla oblongata. + FMA:258772 + SCTID:304943004 nucleus of medulla oblongata + + + + A neural nucleus that is part of a medulla oblongata. + OBOL:automatic + @@ -131490,8 +205644,23 @@ + The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]. + BIRNLEX:4096 + BM:V + CALOHA:TS-2077 + DHBA:266441713 + FMA:71248 + HBA:9203 + Wikipedia:Trigeminal_nerve_nuclei + neuronames:2021 trigeminal nuclear complex + + + + The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]. + Wikipedia:Trigeminal_nerve_nuclei + @@ -131506,11 +205675,46 @@ - - - + An anatomical structure that connects two structures. + FMA:5898 + SCTID:91833003 anatomical junction + + + + An anatomical structure that connects two structures. + http://code.google.com/p/caro2/issues/detail?id=15 + + + + + + + + + + + + + + + + + + + + + A sphincter that is part of an esophagus. + SCTID:277765007 + esophageal sphincter + + + + + A sphincter that is part of an esophagus. + http://orcid.org/0000-0002-6601-2165 + @@ -131519,8 +205723,20 @@ + Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. + AEO:0000170 + EFO:0001649 + EHDAA2:0003170 + Wikipedia:Anlage_(biology) anlage + + + + Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. + FBbt:00005426 + http://flybase.org/reports/FBrf0178740.html + @@ -131535,6 +205751,12 @@ + EFO:0003626 + EHDAA2:0001457 + EHDAA:962 + TAO:0001104 + ZFA:0001104 + relation conflict: ZFA vs EHDAA2. Note EHDAA2 term renamed to 'early PA endoderm' early pharyngeal endoderm @@ -131562,8 +205784,16 @@ + A bone that is part of a reproductive organ. bone of reproductive organ + + + + A bone that is part of a reproductive organ. + OBOL:automatic + https://github.com/obophenotype/uberon/issues/1158 + @@ -131588,8 +205818,16 @@ + A gland that is part of a epidermis. + FMA:59153 epidermis gland + + + + A gland that is part of a epidermis. + OBOL:automatic + @@ -131634,8 +205872,19 @@ + Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces. + FMA:12276 + GAID:1195 + MESH:D005122 + ncithesaurus:Transudate transudate + + + + Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces. + http://medical-dictionary.thefreedictionary.com/transudate + @@ -131661,8 +205910,16 @@ + Any fluid produced by a serous gland. + Wikipedia:Serous_fluid secretion of serous gland + + + + Any fluid produced by a serous gland. + UBERON:cjm + @@ -131676,9 +205933,21 @@ - + Anatomical system that consists of all blood and lymph vessels. + BTO:0001085 + CALOHA:TS-2053 + EHDAA2:0004520 + EMAPA:35905 + MA:0002718 + NCIT:C33854 vascular system + + + + Anatomical system that consists of all blood and lymph vessels. + http://orcid.org/0000-0002-6601-2165 + @@ -131698,8 +205967,20 @@ + Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots. + CALOHA:TS-0002 + EFO:0003771 adipose tissue of abdominal region + + + + Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots. + CALOHA:paula + MGI:csmith + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/259 + @@ -131731,8 +206012,80 @@ + The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. + CALOHA:TS-2356 + EV:0100009 + FMA:280881 + MA:0000006 + NCIT:C12418 + SCTID:361355005 + WikipediaCategory:Head_and_neck + galen:HeadAndNeck craniocervical region + + + + The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton. + AAO:0010338 + MA:0000008 + NCIT:C77663 + TAO:0001117 + XAO:0003026 + ZFA:0001117 + post-anal tail + + + + + A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton. + https://orcid.org/0000-0002-6601-2165 + @@ -131769,8 +206122,56 @@ + An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). + FMA:24874 + VSAO:0000303 appendage girdle region + + + + An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesentery that is located in the peritoneum. + FMA:20570 + TAO:0005129 + XAO:0000138 + ZFA:0005129 + peritoneal mesentery + + + + + Mesentery that is located in the peritoneum. + UBERON:cjm + @@ -131795,8 +206196,17 @@ + A bone that is part of a appendage girdle region. + EMAPA:35379 + MA:0000291 girdle bone/zone + + + + A bone that is part of a appendage girdle region. + OBOL:automatic + @@ -131822,9 +206232,17 @@ - + A bone that is part of a pectoral girdle region. + EMAPA:35669 + MA:0000292 pectoral girdle bone + + + + A bone that is part of a pectoral girdle region. + OBOL:automatic + @@ -131865,8 +206283,29 @@ + A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons. + AAO:0000422 + AAO:0000754 + EFO:0000946 + EHDAA2:0001420 + FMA:24141 + MAT:0000181 + MIAA:0000181 + NCIT:C33547 + TAO:0000407 + VHOG:0001156 + VSAO:0000156 + Wikipedia:Pectoral_girdle + XAO:0003063 + ZFA:0000407 pectoral girdle skeleton + + + + A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons. + Wikipedia:Pectoral_girdle + @@ -131880,8 +206319,24 @@ + Bone element that arises as a result of intramembranous ossification. + AEO:0000085 + EHDAA2:0003085 + TAO:0001645 + VSAO:0000023 + XAO:0004014 + ZFA:0001636 membrane bone + + + + Bone element that arises as a result of intramembranous ossification. + GO_REF:0000034 + VSAO:0000023 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/267 + @@ -131918,8 +206373,24 @@ + Skeletal element that is composed of cartilage tissue and may be permanent or transient. + AAO:0011130 + CALOHA:TS-0118 + FMA:55107 + VSAO:0000000 + XAO:0004013 + ZFA:0001501 cartilage element + + + + Skeletal element that is composed of cartilage tissue and may be permanent or transient. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000000 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -131946,8 +206417,16 @@ + Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue. + FMA:20103 regular connective tissue + + + + Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue. + FMA:20103 + @@ -131971,8 +206450,24 @@ + Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts). + FMA:64781 + NCIT:C33453 + SCTID:22560007 + VSAO:0000050 + Wikipedia:Dense_regular_connective_tissue + XAO:0004030 dense regular connective tissue + + + + Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts). + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000050 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -131997,8 +206492,36 @@ + A bone that is part of a craniocervical region. + MA:0000569 bone of craniocervical region + + + + A bone that is part of a craniocervical region. + OBOL:automatic + + + + + + + + + The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid. + FMA:7477 + NCIT:C32881 + SCTID:421560006 + Wikipedia:Irregular_bone + irregular bone + + + + + The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid. + Wikipedia:Irregular_bone + @@ -132035,8 +206558,16 @@ + A skeletal joint that is part of a appendage girdle region. + MA:0001505 joint of girdle + + + + A skeletal joint that is part of a appendage girdle region. + OBOL:automatic + @@ -132061,8 +206592,53 @@ + An anatomical surface that is part of a cartilage element. + FMA:76668 surface of cartilage + + + + An anatomical surface that is part of a cartilage element. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]. + FMA:7478 + SCTID:333008005 + Wikipedia:Skeletal_pneumaticity + galen:PneumaticBone + pneumatized bone + + + + + A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]. + http://www.medilexicon.com/medicaldictionary.php?t=11303 + @@ -132087,8 +206663,16 @@ + Any muscle organ that is part of a pectoral girdle region. + FMA:37347 muscle of pectoral girdle + + + + Any muscle organ that is part of a pectoral girdle region. + OBOL:automatic + @@ -132113,8 +206697,19 @@ + Musculature system of the pharyngeal and head regions. + MA:0000571 + TAO:0000328 + ZFA:0000328 craniocervical region musculature + + + + Musculature system of the pharyngeal and head regions. + ZFA:0000328 + ZFA:curator + @@ -132134,8 +206729,18 @@ + Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax. + FMA:24217 + MA:0000028 + SCTID:362666008 dorsal thoracic segment of trunk + + + + Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax. + FMA:24217 + @@ -132161,8 +206766,17 @@ + A muscle of back that is part of a dorsal thoracic segment of trunk. + MA:0000508 + SCTID:305071003 upper back muscle + + + + A muscle of back that is part of a dorsal thoracic segment of trunk. + OBOL:automatic + @@ -132187,8 +206801,16 @@ + An endothelium that is part of a heart [Automatically generated definition]. + BTO:0004293 heart endothelium + + + + An endothelium that is part of a heart [Automatically generated definition]. + OBOL:automatic + @@ -132213,11 +206835,84 @@ + BTO:0003122 microvascular endothelium + + + + + + + + + + + + + + + + + + + + + + An intestinal villus in the duodenum. + FMA:63300 + intestinal villus of duodenum + + + + + An intestinal villus in the duodenum. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a duodenum. + CALOHA:TS-2087 + EMAPA:19078 + FMA:17231 + MA:0003208 + SCTID:66036002 + duodenal epithelium + + + + + An epithelium that is part of a duodenum. + OBOL:automatic + + + + @@ -132239,8 +206934,17 @@ + Epithelium pertaining to the trachea and bronchi. + BTO:0002925 + CALOHA:TS-1063 tracheobronchial epithelium + + + + Epithelium pertaining to the trachea and bronchi. + Dorlands_Medical_Dictionary:MerckMedicus + @@ -132271,8 +206975,21 @@ + An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers. + EHDAA2:0000444 + EHDAA:42 + EHDAA:75 + EMAPA:16050 + NCIT:C34164 + The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5. inner cell mass derived epiblast + + + + An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers. + MP:0003886 + @@ -132298,8 +207015,19 @@ + A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]. + EHDAA2:0000187 + FMA:293041 + NCIT:C34248 pharyngeal arch system + + + + A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]. + GO:0060037 + GOC:dph + @@ -132324,8 +207052,17 @@ + A head that is part of a embryo. + CALOHA:TS-0246 + FMA:293011 embryonic head + + + + A head that is part of a embryo. + OBOL:automatic + @@ -132357,8 +207094,16 @@ + A brain that develops_from a neural tube. neural tube derived brain + + + + A brain that develops_from a neural tube. + OBOL:automatic + https://github.com/obophenotype/uberon/issues/338 + @@ -132389,8 +207134,78 @@ + A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein). + EMAPA:36551 + FMA:62780 + MA:0002534 + NCIT:C13273 + Wikipedia:Pulmonary_surfactant pulmonary surfactant + + + + A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein). + Wikipedia:Pulmonary_surfactant + + + + + + + + + + + + + + + + + + + + + + + + + An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts. + AAO:0011057 + EHDAA2:0000740 + EHDAA:1530 + NCIT:C34187 + Wikipedia:Hepatic_diverticulum + XAO:0000101 + hepatic diverticulum + + + + + An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts. + MP:MP + http://www.stembook.org/node/512 + + + + + + + + + + + + + + + + + + BTO:0001642 + liver bud + @@ -132421,8 +207236,162 @@ + Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals. + EMAPA:16080 ectoplacental cavity + + + + Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals. + MP:0011207 + http://www.medilexicon.com/medicaldictionary.php?s=epamniotic+cavity + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines. + FMA:14909 + SCTID:362132003 + stomach muscularis externa + + + + + The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines. + MP:0010779 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter. + FMA:14580 + SCTID:245417002 + Wikipedia:Pyloric_canal + pyloric canal + + + + + The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter. + MP:0010791 + Wikipedia:Pyloric_canal + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]. + EMAPA:27211 + FMA:14922 + NCIT:C33431 + SCTID:70710007 + Wikipedia:Pyloric_gland + pyloric gastric gland + + + + + The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]. + MP:0010797 + Wikipedia:Pyloric_gland + @@ -132471,9 +207440,15 @@ - + The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages. pulmonary alveolar parenchyma + + + + The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages. + MP:0010901 + @@ -132494,9 +207469,22 @@ - + The largest lung subunit in which all airways participate in gas exchange, and it is composed of the parenchyma of the respiratory bronchioles, alveolar ducts, and alveoli. + FMA:7313 + NCIT:C33426 + SCTID:361365004 + Wikipedia:Acinus#The_Lungs pulmonary acinus + + + + The largest lung subunit in which all airways participate in gas exchange, and it is composed of the parenchyma of the respiratory bronchioles, alveolar ducts, and alveoli. + MP:0010911 + PMID:2014492 + PMID:3382030 + Wikipedia:Acinus#The_Lungs + @@ -132547,8 +207535,18 @@ + Any skeletal muscle organ in the hypodermis / superficial fascia. + EMAPA:18188 + MA:0003140 hypodermis skeletal muscle layer + + + + Any skeletal muscle organ in the hypodermis / superficial fascia. + ISBN:0123813611 + MP:0011157 + @@ -132568,9 +207566,18 @@ - + The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins. + FMA:45621 + Wikipedia:Pulmonary_circulation pulmonary vascular system + + + + The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins. + ISBN:0073040584 + Wikipedia:Pulmonary_circulation + @@ -132591,9 +207598,24 @@ - + Subdivision of endoskeleton derived from pharyngeal arches. + AAO:0010157 + TAO:0001216 + VHOG:0000315 + VSAO:0000149 + Wikipedia:Facial_skeleton + XAO:0003176 + ZFA:0001216 splanchnocranium + + + + Subdivision of endoskeleton derived from pharyngeal arches. + ISBN:0073040584 + Wikipedia:Facial_skeleton + https://orcid.org/0000-0002-6601-2165 + @@ -132619,8 +207641,24 @@ + Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]. + AAO:0010769 + TAO:0001590 + VSAO:0000130 + Wikipedia:Dermal_bone + XAO:0004015 + ZFA:0001590 dermal bone + + + + Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]. + GO_REF:0000034 + VSAO:0000130 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/267 + @@ -132645,8 +207683,21 @@ + Bone element that is adjacent to the notochord. + AAO:0010777 + TAO:0001639 + VSAO:0000307 + ZFA:0001629 perichordal bone + + + + Bone element that is adjacent to the notochord. + GO_REF:0000034 + VSAO:0000307 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -132672,8 +207723,19 @@ + A parenchyma that is part of a lung. + EMAPA:35522 + FMA:27360 + MA:0003168 + SCTID:201712001 lung parenchyma + + + + A parenchyma that is part of a lung. + OBOL:automatic + @@ -132693,6 +207755,8 @@ + EHDAA2:0004069 + NCIT:C34283 respiratory primordium @@ -132719,8 +207783,65 @@ + A lobe of lung that is part of a left lung. + EHDAA:2981 + NCIT:C48945 + SCTID:272655003 left lung lobe + + + + A lobe of lung that is part of a left lung. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed. + BTO:0003634 + FMA:9404 + NCIT:C32536 + SCTID:322749003 + Wikipedia:Esophageal_glands + submucosal esophageal gland + + + + + One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed. + BTO:0003634 + Wikipedia:Esophageal_glands + @@ -132735,8 +207856,23 @@ + System pertaining to blood vessels in the brain. + BTO:0003840 + EFO:0003491 + EMAPA:35186 + FMA:242007 + FMA:61935 + SCTID:362029003 + TAO:0000099 + ZFA:0000099 vasculature of brain + + + + System pertaining to blood vessels in the brain. + BTO:0003840 + @@ -132762,8 +207898,17 @@ + A zone of skin that is part of a dorsal thoracic segment of trunk. + MA:0000510 + SCTID:304890003 upper back skin + + + + A zone of skin that is part of a dorsal thoracic segment of trunk. + OBOL:automatic + @@ -132788,8 +207933,18 @@ + Vein that drains left lung and returns blood to the heart. + MA:0002207 + NCIT:C48946 + SCTID:304057004 left pulmonary vein + + + + Vein that drains left lung and returns blood to the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -132814,8 +207969,18 @@ + Vein that drains right lung and returns blood to the heart. + MA:0002208 + NCIT:C48947 + SCTID:304056008 right pulmonary vein + + + + Vein that drains right lung and returns blood to the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -132829,8 +207994,18 @@ + A gonad prior to differentiating into a definitive testis or ovary. + EHDAA2:0000716 + NCIT:C34192 + typically part of the embryo - however, in male tammar wallabies the gonads are indifferent at the neonatal stage[8827321] indifferent gonad + + + + A gonad prior to differentiating into a definitive testis or ovary. + http://www.medterms.com/script/main/art.asp?articlekey=8981 + @@ -132856,9 +208031,19 @@ - + Cranial ganglion which develops from an epibranchial placode. + TAO:0001555 + ZFA:0001555 + Epibranchial ganglia orchestrate the development of the cranial neurogenic crest epibranchial ganglion + + + + Cranial ganglion which develops from an epibranchial placode. + PMID:20133851 + ZFIN:curator + @@ -132898,8 +208083,20 @@ + Endocardium that is part of the right atrium. + EHDAA2:0000274 + FMA:7281 + NCIT:C102339 + SCTID:3194006 + VHOG:0001228 right atrium endocardium + + + + Endocardium that is part of the right atrium. + http://orcid.org/0000-0002-6601-2165 + @@ -132920,8 +208117,22 @@ + A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities. + EHDAA2:0001483 + EMAPA:17709 + NCIT:C34256 + SCTID:361429005 + VHOG:0000757 + Wikipedia:Pleuroperitoneal pleuroperitoneal membrane + + + + A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities. + Wikipedia:Pleuroperitoneal + http://medical-dictionary.thefreedictionary.com/pleuroperitoneal+membrane + @@ -132946,8 +208157,17 @@ + A vein that is part of a craniocervical region. + EHDAA2:0004542 + SCTID:32945007 craniocervical region vein + + + + A vein that is part of a craniocervical region. + OBOL:automatic + @@ -132973,8 +208193,18 @@ + Sum total of mesenchyme in the embryo. + EHDAA2:0001113 + EHDAA:177 + EMAPA:16097 entire embryonic mesenchyme + + + + Sum total of mesenchyme in the embryo. + https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/7 + @@ -132988,11 +208218,102 @@ + EMAPA:16549 + RETIRED_EHDAA2:0001454 pharyngeal region of foregut + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation. + EHDAA2:0003446 + EMAPA:18015 + sphenoid bone pre-cartilage condensation + + + + + A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A sphenoid endochondral element that is composed primarily of cartilage tissue. + EHDAA2:0001888 + sphenoid cartilage element + + + + + A sphenoid endochondral element that is composed primarily of cartilage tissue. + OBOL:automatic + + + + @@ -133003,11 +208324,61 @@ + EHDAA2:0004021 indifferent external genitalia + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a medial nasal prominence. + EHDAA2:0001077 + EMAPA:16810 + FMA:312659 + medial nasal process mesenchyme + + + + + Mesenchyme that is part of a medial nasal prominence. + OBOL:automatic + + + + + + + + + EHDAA2:0000581 + EHDAA:4776 + EMAPA:16680 + SCTID:308881001 + embryonic nasal process + + + + @@ -133029,8 +208400,17 @@ + An ectoderm that is part of a buccopharyngeal membrane. + EHDAA2:0000190 + EMAPA:16260 ectoderm of buccopharyngeal membrane + + + + An ectoderm that is part of a buccopharyngeal membrane. + OBOL:automatic + @@ -133055,8 +208435,88 @@ + An endoderm that is part of a buccopharyngeal membrane. + EHDAA2:0000191 + EMAPA:16261 endoderm of buccopharyngeal membrane + + + + An endoderm that is part of a buccopharyngeal membrane. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a foregut-midgut junction. + EHDAA2:0000570 + EMAPA:16364 + associated mesenchyme of foregut-midgut junction + + + + + Mesenchyme that is part of a foregut-midgut junction. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mesentery that is part of a foregut-midgut junction. + EHDAA2:0000575 + EMAPA:16365 + VHOG:0000430 + mesentery of foregut-midgut junction + + + + + A mesentery that is part of a foregut-midgut junction. + OBOL:automatic + @@ -133094,8 +208554,143 @@ + A portion of mesenchymal tissue associated with an individual pharyngeal arch. + EMAPA:32755 + FMA:295694 pharyngeal arch mesenchymal region + + + + A portion of mesenchymal tissue associated with an individual pharyngeal arch. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a foregut-midgut junction. + EHDAA2:0000573 + EMAPA:16564 + epithelium of foregut-midgut junction + + + + + An epithelium that is part of a foregut-midgut junction. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head. + EHDAA2:0004109 + EMAPA:16683 + FMA:295821 + mesenchyme of fronto-nasal process + + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head. + MP:0011266 + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a developing hindgut. + EHDAA2:0000780 + EMAPA:16716 + mesenchyme of hindgut + + + + + Mesenchyme that is part of a developing hindgut. + OBOL:automatic + @@ -133127,8 +208722,293 @@ + Mesenchyme that is part of a developing trachea. + EHDAA2:0002067 + EMAPA:16854 mesenchyme of trachea + + + + Mesenchyme that is part of a developing trachea. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm that is part of a anal region. + EHDAA2:0004020 + EMAPA:17177 + anal membrane endodermal component + + + + + An endoderm that is part of a anal region. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a maxillary prominence. + EHDAA2:0001071 + EMAPA:17361 + FMA:312691 + maxillary process mesenchyme + + + + + Mesenchyme that is part of a maxillary prominence. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic sinusoid that is part of a left lobe of liver. + EHDAA2:0001001 + EMAPA:18309 + VHOG:0000709 + hepatic sinusoid of left of lobe of liver + + + + + A hepatic sinusoid that is part of a left lobe of liver. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic sinusoid that is part of a right lobe of liver. + EHDAA2:0001009 + EMAPA:18316 + VHOG:0000710 + hepatic sinusoid of right of lobe of liver + + + + + A hepatic sinusoid that is part of a right lobe of liver. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm that is part of a foregut-midgut junction. + EHDAA2:0000572 + EMAPA:18403 + endoderm of foregut-midgut junction + + + + + An endoderm that is part of a foregut-midgut junction. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a intestine. + FMA:15696 + intestinal submucosa + + + + + A submucosa that is part of a intestine. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions. + FMA:72066 + NCIT:C92597 + SCTID:281699004 + trunk region of vertebral column + + + + + Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions. + UBERONREF:0000006 + @@ -133142,6 +209022,8 @@ + FMA:25054 + SCTID:22943007 subdivision of trunk @@ -133168,8 +209050,18 @@ + A sulcus limitans of neural tube that is part of a future spinal cord. + EHDAA2:0001265 + EMAPA:17584 + VHOG:0001548 spinal cord sulcus limitans + + + + A sulcus limitans of neural tube that is part of a future spinal cord. + OBOL:automatic + @@ -133200,8 +209092,17 @@ + A sulcus limitans of neural tube that is part of a future medulla oblongata. + EHDAA2:0001100 + EMAPA:17561 medulla oblongata sulcus limitans + + + + A sulcus limitans of neural tube that is part of a future medulla oblongata. + OBOL:automatic + @@ -133226,8 +209127,17 @@ + A sulcus limitans of neural tube that is part of a future metencephalon. + EHDAA2:0001161 + EMAPA:17567 metencephalon sulcus limitans + + + + A sulcus limitans of neural tube that is part of a future metencephalon. + OBOL:automatic + @@ -133252,8 +209162,16 @@ + A sulcus limitans of neural tube that is part of a future myelencephalon. + EHDAA2:0001945 myelencephalon sulcus limitans + + + + A sulcus limitans of neural tube that is part of a future myelencephalon. + OBOL:automatic + @@ -133278,6 +209196,9 @@ + EHDAA2:0001172 + EMAPA:16977 + VHOG:0000910 midbrain mantle layer @@ -133304,6 +209225,8 @@ + EMAPA:17580 + VHOG:0000911 spinal cord mantle layer @@ -133330,8 +209253,17 @@ + Mesenchyme that is part of a 1st arch mandibular component. + EHDAA2:0000034 + EMAPA:16385 1st arch mandibular mesenchyme + + + + Mesenchyme that is part of a 1st arch mandibular component. + OBOL:automatic + @@ -133356,8 +209288,18 @@ + Mesenchyme that is part of a developing left lung. + EHDAA2:0000944 + EMAPA:16730 + EMAPA:17654 left lung associated mesenchyme + + + + Mesenchyme that is part of a developing left lung. + OBOL:automatic + @@ -133382,8 +209324,17 @@ + Mesenchyme that is part of a developing right lung. + EHDAA2:0001739 + EMAPA:17662 right lung associated mesenchyme + + + + Mesenchyme that is part of a developing right lung. + OBOL:automatic + @@ -133403,8 +209354,17 @@ + A neural plate that develops_from a presumptive midbrain. + TAO:0007019 + ZFA:0007019 midbrain neural plate + + + + A neural plate that develops_from a presumptive midbrain. + OBOL:automatic + @@ -133424,8 +209384,17 @@ + A neural plate that develops_from a presumptive hindbrain. + TAO:0007022 + ZFA:0007022 hindbrain neural plate + + + + A neural plate that develops_from a presumptive hindbrain. + OBOL:automatic + @@ -133445,6 +209414,8 @@ + TAO:0007044 + ZFA:0007044 midbrain hindbrain boundary neural plate @@ -133489,8 +209460,22 @@ + A presumptive structure that has the potential to develop into a midbrain. + BAMS:MES + EFO:0003432 + EHDAA2:0000615 + EMAPA:16140 + TAO:0000148 + Wikipedia:Mesencephalon + ZFA:0000148 presumptive midbrain + + + + A presumptive structure that has the potential to develop into a midbrain. + OBOL:automatic + @@ -133510,8 +209495,18 @@ + Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles. + EHDAA2:0000736 + EHDAA:364 + EMAPA:16171 head paraxial mesoderm + + + + Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles. + PMID:21610022 + @@ -133531,16 +209526,54 @@ + EHDAA2:0002094 trunk paraxial mesoderm + + + + + + + + + + + + + + + + + + + + + + A somite that is part of a tail. + AAO:0010383 + EMAPA:16860 + XAO:0003143 + tail somite + + + + + A somite that is part of a tail. + OBOL:automatic + + + + - + EMAPA:35878 + MA:0001859 trachea non-cartilage connective tissue @@ -133568,8 +209601,17 @@ + A basement membrane that is part of a bronchus. + MA:0001832 + NCIT:C49208 bronchus basement membrane + + + + A basement membrane that is part of a bronchus. + OBOL:automatic + @@ -133601,8 +209643,17 @@ + A basement membrane that is part of a trachea. + MA:0001854 + NCIT:C49302 trachea basement membrane + + + + A basement membrane that is part of a trachea. + OBOL:automatic + @@ -133627,6 +209678,8 @@ + MA:0001987 + NCIT:C52947 artery of lip @@ -133653,8 +209706,18 @@ + Nucleus located in the midbrain. + SCTID:279285003 + TAO:0002209 + ZFA:0001665 midbrain nucleus + + + + Nucleus located in the midbrain. + ZFIN:curator + @@ -133679,8 +209742,196 @@ + Nucleus located within the hindbrain. + TAO:0002177 + ZFA:0001658 hindbrain nucleus + + + + Nucleus located within the hindbrain. + ZFIN:curator + + + + + + + + + + + + + + + EHDAA2:0004566 + EMAPA:32911 + MA:0003203 + gut mesentery + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that surrounded_by a embryonic cloaca. + EHDAA2:0004586 + embryonic cloacal lumen + + + + + An anatomical space that surrounded_by a embryonic cloaca. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that surrounded_by a rectum. + EHDAA2:0004587 + EMAPA:18388 + FMA:14598 + SCTID:259740004 + rectal lumen + + + + + An anatomical space that surrounded_by a rectum. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0001371 + dorsal pancreas + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0001393 + ventral pancreas + @@ -133717,8 +209968,21 @@ + Any endocardium that is part of the right ventricle of the heart. + EHDAA2:0002188 + EMAPA:17341 + FMA:9536 + NCIT:C102343 + SCTID:8911002 + VHOG:0001235 endocardium of right ventricle + + + + Any endocardium that is part of the right ventricle of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -133749,8 +210013,20 @@ + Any endocardium that is part of the left ventricle of the heart. + EHDAA2:0002182 + EMAPA:17338 + FMA:9559 + SCTID:191004004 + VHOG:0001233 endocardium of left ventricle + + + + Any endocardium that is part of the left ventricle of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -133775,8 +210051,15 @@ + An anatomical cavity that surrounded_by a stomodeum. stomodeal lumen + + + + An anatomical cavity that surrounded_by a stomodeum. + OBOL:automatic + @@ -133798,6 +210081,9 @@ + EHDAA2:0004621 + EMAPA:32754 + FMA:293087 entire pharyngeal arch endoderm @@ -133825,8 +210111,52 @@ + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures. + EHDAA2:0004162 + EMAPA:36438 cardiac mesenchyme + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures. + MP:0011264 + + + + + + + + + + + + + + + + + + + + + + + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas. + EFO:0002557 + EMAPA:26220 + pancreas mesenchyme + + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas. + MP:0011265 + @@ -133851,8 +210181,16 @@ + A ganglion that is part of a abdominal segment of trunk. + SCTID:280508003 abdominal ganglion + + + + A ganglion that is part of a abdominal segment of trunk. + OBOL:automatic + @@ -133901,8 +210239,18 @@ + A serous sac that has the pleura and the pleural cavity as parts. + EHDAA2:0004737 + FMA:9690 + SCTID:361996004 pleural sac + + + + A serous sac that has the pleura and the pleural cavity as parts. + https://github.com/obophenotype/uberon/issues/86 + @@ -133947,8 +210295,65 @@ + The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. + FMA:55588 + Wikipedia:Acinus glandular acinus + + + + The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. + Wikipedia:Acinus + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a embryonic cloaca. + EHDAA2:0004585 + embryonic cloacal epithelium + + + + + An epithelium that is part of a embryonic cloaca. + OBOL:automatic + @@ -133968,8 +210373,15 @@ + Branch or outpocketing of the digestive tract. digestive tract diverticulum + + + + Branch or outpocketing of the digestive tract. + https://orcid.org/0000-0002-6601-2165 + @@ -133994,6 +210406,7 @@ + galen:Diverticulum sac @@ -134021,8 +210434,21 @@ + A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland. + EMAPA:35821 + FMA:14558 + MA:0002561 + SCTID:245415005 + Wikipedia:Stomach#Sections zone of stomach + + + + A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland. + ISBN:0073040584 + Wikipedia:Stomach#Sections + @@ -134037,6 +210463,9 @@ + EFO:0003704 + TAO:0005041 + ZFA:0005041 anterior lateral plate mesoderm @@ -134073,8 +210502,18 @@ + A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract). + XAO:0004186 secondary heart field + + + + A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract). + GO:0003139 + GOC:mtg_heart + GOC:rl + @@ -134099,8 +210538,17 @@ + Mesenchyme that is part of a developing face. + EMAPA:35337 + FMA:302884 facial mesenchyme + + + + Mesenchyme that is part of a developing face. + OBOL:automatic + @@ -134108,6 +210556,8 @@ + FMA:45737 + NCIT:C12990 lobule @@ -134117,8 +210567,18 @@ + A portion of an organ, such as the liver, lung, breast, or brain. + FMA:45728 + NCIT:C13393 + UMLS:C0796494 anatomical lobe + + + + A portion of an organ, such as the liver, lung, breast, or brain. + ncithesaurus:Lobe + @@ -134133,6 +210593,8 @@ + EHDAA2:0001315 + EHDAA:1122 optic neural crest @@ -134159,8 +210621,16 @@ + A multicellular organism that existence_starts_with a post-embryonic stage. + MA:0002405 post-embryonic organism + + + + A multicellular organism that existence_starts_with a post-embryonic stage. + OBOL:automatic + @@ -134212,8 +210682,58 @@ + Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia. + EFO:0003460 + TAO:0001309 + Wikipedia:Neurogenic_placodes + XAO:0004620 + ZFA:0001309 neurogenic placode + + + + Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia. + PMID:11523831 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a pancreatic duct. + EFO:0002556 + FMA:67681 + epithelium of pancreatic duct + + + + + An epithelium that is part of a pancreatic duct. + OBOL:automatic + @@ -134244,11 +210764,16 @@ - - - + An anatomical structure that has more than one cell as a part. + CARO:0010000 multicellular anatomical structure + + + + An anatomical structure that has more than one cell as a part. + CARO:0010000 + @@ -134283,8 +210808,16 @@ + A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]. + NLXANAT:20090509 aggregate regional part of brain + + + + A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]. + NLXANAT:20090509 + @@ -134309,8 +210842,18 @@ + Mesenchyme that is part of a pharyngeal arch 6. + EHDAA2:0004076 + EMAPA:32765 + FMA:318209 6th arch mesenchyme + + + + Mesenchyme that is part of a pharyngeal arch 6. + OBOL:automatic + @@ -134330,8 +210873,18 @@ + An organ of the digestive tract that is capable of retaining and storing food. + BSA:0000123 + TADS:0000172 + TGMA:0001041 food storage organ + + + + An organ of the digestive tract that is capable of retaining and storing food. + https://orcid.org/0000-0002-6601-2165 + @@ -134356,8 +210909,51 @@ + Mesenchyme that is part of a pharyngeal arch 1. + EMAPA:16128 1st arch mesenchyme + + + + Mesenchyme that is part of a pharyngeal arch 1. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a 1st arch maxillary component. + EHDAA2:0000041 + EMAPA:16391 + 1st arch maxillary mesenchyme + + + + + Mesenchyme that is part of a 1st arch maxillary component. + OBOL:automatic + @@ -134378,8 +210974,19 @@ + The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells. + EHDAA2:0001459 + EMAPA:16550 + XAO:0004524 entire pharyngeal arch associated mesenchyme + + + + The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells. + XAO:0004524 + https://orcid.org/0000-0002-6601-2165 + @@ -134405,8 +211012,20 @@ + Gland of the epithelium lining the oral cavity. The most common are the salivary glands. + EHDAA2:0001327 + EHDAA:2181 + EMAPA:16572 + EMAPA:16723 + VHOG:0000652 oral gland + + + + Gland of the epithelium lining the oral cavity. The most common are the salivary glands. + ISBN:0073040584 + @@ -134414,8 +211033,60 @@ + An epithelium consisting of cuboidal epithelial cells. + NCIT:C32415 + Wikipedia:Cuboidal_epithelium cuboidal epithelium + + + + An epithelium consisting of cuboidal epithelial cells. + Wikipedia:Cuboidal_epithelium + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An extrahepatic bile duct that has the potential to develop into a common hepatic duct. + EHDAA2:0000595 + future common hepatic duct + + + + + An extrahepatic bile duct that has the potential to develop into a common hepatic duct. + OBOL:automatic + @@ -134458,8 +211129,16 @@ + Mesenchyme that has the potential to develop into a dermis. + EHDAA2:0000598 future dermis + + + + Mesenchyme that has the potential to develop into a dermis. + OBOL:automatic + @@ -134502,8 +211181,16 @@ + A structure that will develop into a diaphragm. + EHDAA2:0000599 future diaphragm + + + + A structure that will develop into a diaphragm. + http://orcid.org/0000-0002-6601-2165 + @@ -134534,8 +211221,16 @@ + A developing anatomical structure that has the potential to develop into a metencephalon. + EHDAA2:0000623 future metencephalon + + + + A developing anatomical structure that has the potential to develop into a metencephalon. + OBOL:automatic + @@ -134566,8 +211261,16 @@ + A developing anatomical structure that has the potential to develop into a myelencephalon. + EHDAA2:0000640 future myelencephalon + + + + A developing anatomical structure that has the potential to develop into a myelencephalon. + OBOL:automatic + @@ -134592,8 +211295,16 @@ + A gray matter that has the potential to develop into a superior salivatory nucleus. + EHDAA2:0004644 future superior salivatory nucleus + + + + A gray matter that has the potential to develop into a superior salivatory nucleus. + OBOL:automatic + @@ -134601,8 +211312,17 @@ + Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers. + EHDAA2:0004528 + FMA:83378 conducting tissue of heart + + + + Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers. + http://orcid.org/0000-0002-6601-2165 + @@ -134610,8 +211330,48 @@ + An epithelial sheet is a flat surface consisting of closely packed epithelial cells. epithelial sheet + + + + An epithelial sheet is a flat surface consisting of closely packed epithelial cells. + GO:0002011 + + + + + + + + + + + + + + + + + + + + + + + + + + A mucous secretion that is produced by glands in the epidermis. + skin mucus + + + + + A mucous secretion that is produced by glands in the epidermis. + http://orcid.org/0000-0002-6601-2165 + @@ -134642,8 +211402,93 @@ + An anatomical cavity that surrounded_by a blood vessel. + FMA:312610 + SCTID:91747007 lumen of blood vessel + + + + An anatomical cavity that surrounded_by a blood vessel. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The distal end of the tail. + MA:0002848 + XAO:0004057 + post-anal tail tip + + + + + The distal end of the tail. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + A trabecula that is part of a liver. + liver trabecula + + + + + A trabecula that is part of a liver. + GO:0060344 + OBOL:automatic + @@ -134651,8 +211496,18 @@ + A roughly circular bulge in a surface. + AEO:0000205 + EHDAA2:0003250 + FMA:82506 protuberance + + + + A roughly circular bulge in a surface. + EHDAA2:0003250 + @@ -134672,6 +211527,7 @@ + EHDAA2:0004512 aortic system @@ -134698,8 +211554,46 @@ + One of the laterally paired arteries that supply the gonads. + Wikipedia:Gonadal_artery genital artery + + + + One of the laterally paired arteries that supply the gonads. + ISBN:0073040584 + Wikipedia:Gonadal_artery + + + + + + + + + + + + + + + + + + + + + A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver. + AAO:0010225 + hepatic portal system + + + + + A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver. + ISBN:0073040584 + @@ -134707,8 +211601,53 @@ + An anatomical boundary that corresponds to some physical discontinuity. + CARO:0001004 + One might argue that all boundaries are actually fiat in the sense that there must be some fiat element at a fine enough scale of granularity. This ontology choses to ignore this issue as below the level of granularity relevant to anatomy. (DOS121102) bona-fide anatomical boundary + + + + An anatomical boundary that corresponds to some physical discontinuity. + CARO:0001004 + + + + + + + + + + + + + + + + + + + + + + + + + + A vasculature that is part of a post-anal tail. + TAO:0005037 + XAO:0004151 + ZFA:0005037 + tail vasculature + + + + + A vasculature that is part of a post-anal tail. + OBOL:automatic + @@ -134728,8 +211667,18 @@ + Multi-tissue structure that is part of the heart tube and will become the cardiac atrium. + FMA:71005 + TAO:0002228 + ZFA:0001718 future cardiac atrium + + + + Multi-tissue structure that is part of the heart tube and will become the cardiac atrium. + ZFA:0001718 + @@ -134750,8 +211699,20 @@ + The core globe-shaped component of the camera-type eye. + FMA:12513 + MIAA:0000283 + SCTID:244486005 + VHOG:0001616 + Wikipedia:Globe_(human_eye) eyeball of camera-type eye + + + + The core globe-shaped component of the camera-type eye. + UBERON:cjm + @@ -134776,8 +211737,20 @@ + An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged. + BTO:0002324 + MA:0003041 + Wikipedia:Merocrine merocrine gland + + + + An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged. + MGI:anna + MP:0013544 + Wikipedia:Merocrine + @@ -134819,8 +211792,61 @@ + Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme. + EHDAA2:0000037 1st arch mandibular mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme. + EHDAA2:0000044 + 1st arch maxillary mesenchyme from neural crest + + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme. + OBOL:automatic + @@ -134857,8 +211883,18 @@ + Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme. + EHDAA2:0000098 + EMAPA:16772 + VHOG:0000580 4th arch mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme. + OBOL:automatic + @@ -134895,8 +211931,16 @@ + Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme. + EHDAA2:0004077 6th arch mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme. + OBOL:automatic + @@ -134927,8 +211971,16 @@ + Mesenchyme that develops_from a rhombencephalon neural crest. + EHDAA2:0004423 mesenchyme from rhombencephalic neural crest + + + + Mesenchyme that develops_from a rhombencephalon neural crest. + OBOL:automatic + @@ -134959,8 +212011,50 @@ + Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme. + EMAPA:16129 1st arch mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Any anatomical space that is part of a vertebral column. + AAO:0000700 + space in vertebral column + + + + + Any anatomical space that is part of a vertebral column. + OBOL:automatic + @@ -134980,8 +212074,20 @@ + Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. + DHBA:12322 + EFO:0003567 + EHDAA2:0004375 + TAO:0000761 + ZFA:0000761 midbrain basal plate + + + + Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. + ZFA:0000761 + @@ -134996,8 +212102,17 @@ + Portion of neural tube that gives rise to the midbrain. + TAO:0007039 + ZFA:0007039 midbrain neural tube + + + + Portion of neural tube that gives rise to the midbrain. + ZFA:0007039 + @@ -135012,6 +212127,7 @@ + Wikipedia:Sclera#Histology layer of sclera @@ -135034,8 +212150,15 @@ + An endothelium that is part of a sclera. scleral endothelium + + + + An endothelium that is part of a sclera. + OBOL:automatic + @@ -135055,8 +212178,18 @@ + A stroma that is part of a sclera. + FMA:58365 + NCIT:C33652 + SCTID:368851004 substantia propria of sclera + + + + A stroma that is part of a sclera. + OBOL:automatic + @@ -135087,8 +212220,16 @@ + Mesenchyme surrounding the developing optic cup which develops into the sclera. scleral mesenchyme + + + + Mesenchyme surrounding the developing optic cup which develops into the sclera. + PMID:16496288 + https://orcid.org/0000-0002-6601-2165 + @@ -135114,8 +212255,15 @@ + An epithelium that is part of a extraembryonic structure. extraembryonic epithelium + + + + An epithelium that is part of a extraembryonic structure. + OBOL:automatic + @@ -135146,8 +212294,17 @@ + Developing anatomical structure that develops into the eyeball and associated structures. + TAO:0002201 + ZFA:0001678 immature eye + + + + Developing anatomical structure that develops into the eyeball and associated structures. + ZFA:0001678 + @@ -135173,8 +212330,15 @@ + An anatomical structure that develops from the neural crest. neural crest-derived structure + + + + An anatomical structure that develops from the neural crest. + https://orcid.org/0000-0002-6601-2165 + @@ -135199,8 +212363,15 @@ + An anatomical structure that has some part that develops from the neural crest. structure with developmental contribution from neural crest + + + + An anatomical structure that has some part that develops from the neural crest. + https://orcid.org/0000-0002-6601-2165 + @@ -135248,8 +212419,15 @@ + A skeletal element that is part of a orbital region. skeletal element of eye region + + + + A skeletal element that is part of a orbital region. + OBOL:automatic + @@ -135269,8 +212447,25 @@ + Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. + AAO:0000109 + AAO:0000971 + AAO:0010185 + TAO:0000737 + VSAO:0000049 + XAO:0003075 + ZFA:0000737 cranial skeletal system + + + + Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000049 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -135301,8 +212496,15 @@ + Mesenchyme that is part of a limb/fin bud. paired limb/fin bud mesenchyme + + + + Mesenchyme that is part of a limb/fin bud. + OBOL:automatic + @@ -135335,8 +212537,105 @@ + Mesenchyme that is part of a extraembryonic membrane. extraembryonic membrane mesenchyme + + + + Mesenchyme that is part of a extraembryonic membrane. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme. + EHDAA2:0004601 + maxillary process mesenchyme from neural crest + + + + + Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme. + EHDAA2:0004602 + maxillary process mesenchyme from head mesenchyme + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme. + OBOL:automatic + @@ -135372,8 +212671,16 @@ + Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme. + EHDAA2:0004603 mandibular process mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme. + OBOL:automatic + @@ -135409,8 +212716,55 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme. + EHDAA2:0004604 mandibular process mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme. + EHDAA2:0000043 + 1st arch maxillary mesenchyme from head mesenchyme + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme. + OBOL:automatic + @@ -135440,8 +212794,16 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme. + EHDAA2:0000036 1st arch mandibular mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme. + OBOL:automatic + @@ -135472,8 +212834,16 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme. + EMAPA:16130 1st arch mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme. + OBOL:automatic + @@ -135504,8 +212874,17 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme. + EHDAA2:0000097 + EMAPA:16771 4th arch mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme. + OBOL:automatic + @@ -135536,8 +212915,16 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme. + EHDAA2:0004078 6th arch mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme. + OBOL:automatic + @@ -135567,8 +212954,16 @@ + Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme. + Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme pharyngeal arch mesenchyme from neural crest + + + + Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme. + OBOL:automatic + @@ -135605,8 +213000,16 @@ + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme. + Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme pharyngeal arch mesenchyme from head mesenchyme + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme. + OBOL:automatic + @@ -135626,8 +213029,21 @@ + Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues. + VSAO:0000037 + Wikipedia:Endoskeleton + XAO:0004026 endoskeleton + + + + Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000037 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -135635,8 +213051,21 @@ + A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification. + VSAO:0000139 + XAO:0004017 + ZFA:0005620 endochondral element + + + + A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000139 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -135650,8 +213079,21 @@ + Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements. + VSAO:0000035 + XAO:0004025 + This ontology covers metazoa, so we do not use exoskeleton as primary label, as in VSAO dermal skeleton + + + + Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000035 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -135677,8 +213119,17 @@ + The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa. + FMA:75739 + NCIT:C33428 pulmonary lobule + + + + The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa. + ncithesaurus:Pulmonary_Lobule + @@ -135692,9 +213143,16 @@ - + A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa. + FMA:7414 secondary pulmonary lobule + + + + A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa. + PMID:3259815 + @@ -135720,8 +213178,86 @@ + Epithelium composed of cells that develops from the ectoderm[FMA,modified]. + FMA:69064 ecto-epithelium + + + + Epithelium composed of cells that develops from the ectoderm[FMA,modified]. + FMA:69064 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0001384 + FMA:79793 + pancreas dorsal primordium + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0001387 + FMA:79794 + pancreas ventral primordium + @@ -135758,8 +213294,16 @@ + Mesenchyme that develops_from a somatopleure. + EHDAA2:0001120 mesenchyme from somatopleure + + + + Mesenchyme that develops_from a somatopleure. + OBOL:automatic + @@ -135796,8 +213340,115 @@ + Mesenchyme that develops_from a splanchnopleure. + EHDAA2:0001122 mesenchyme from splanchnopleure + + + + Mesenchyme that develops_from a splanchnopleure. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of the branches of the splenic artery[MP]. + MA:0000759 + NCIT:C49775 + Wikipedia:Trabecular_arteries + spleen trabecular artery + + + + + One of the branches of the splenic artery[MP]. + MP:0002354 + Wikipedia:Trabecular_arteries + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of the veins that feed the splenic vein. + MA:0000760 + NCIT:C49779 + Wikipedia:Trabecular_veins + spleen trabecular vein + + + + + One of the veins that feed the splenic vein. + MP:0002228 + Wikipedia:Trabecular_veins + @@ -135818,8 +213469,17 @@ + The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms. + EMAPA:35336 + MA:0002486 ocular surface region + + + + The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms. + MP:0013754 + @@ -135834,8 +213494,18 @@ + The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens. + FMA:76551 + SCTID:280860001 + Wikipedia:Ciliary_processes ciliary processes + + + + The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens. + Wikipedia:Ciliary_processes + @@ -135849,8 +213519,21 @@ + A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow. + FMA:7476 + NCIT:C32616 + SCTID:332907008 + Wikipedia:Flat_bone + galen:FlatBone + Examples: cranium, the ilium, sternum, rib cage, the sacrum and the scapula; the occipital, parietal, frontal, nasal, lacrimal, vomer, scapula, os coxC&, sternum, and ribs flat bone + + + + A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow. + Wikipedia:Flat_bone + @@ -135858,8 +213541,20 @@ + A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels. + FMA:45572 + NCIT:C33419 + NCIT:C49316 + Wikipedia:Pseudostratified_columnar_epithelium pseudostratified columnar epithelium + + + + A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels. + Wikipedia:Pseudostratified_columnar_epithelium + http://medical-dictionary.thefreedictionary.com/pseudostratified+epithelium + @@ -135879,8 +213574,17 @@ + Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile. + FMA:13146 + NCIT:C13181 pseudostratified ciliated columnar epithelium + + + + Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile. + NCIT:NCIT + @@ -135894,8 +213598,21 @@ + Skeletal element that forms as a replacement or substitution of another element or tissue. + VSAO:0000135 + XAO:0004016 + ZFA:0005624 replacement element + + + + Skeletal element that forms as a replacement or substitution of another element or tissue. + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000135 + http://dx.plos.org/10.1371/journal.pone.0051070 + @@ -135909,8 +213626,70 @@ + A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses. + MESH:D055806 + TAO:0005251 + ZFA:0005251 microcirculatory vessel + + + + A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses. + MESH:A07.231.432 + ZFA:0005251 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + An organ cavity that surrounded_by a bone. + FMA:24021 + cavity of bone organ + + + + + An organ cavity that surrounded_by a bone. + OBOL:automatic + + + + + + + + + + + + + + + FMA:24028 + pneumatic cavity of bone + @@ -135937,8 +213716,18 @@ + An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). + FMA:7182 + VSAO:0000214 appendage girdle complex + + + + An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). + https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton + https://orcid.org/0000-0002-6601-2165 + @@ -135969,8 +213758,18 @@ + Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle. + FMA:7183 + SCTID:110716002 + VSAO:0000213 pectoral complex + + + + Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle. + VSAO:0000213 + @@ -136013,8 +213812,17 @@ + The subdivision of the skeleton of either the pectoral or pelvic girdle. + AAO:0010686 + VSAO:0000302 girdle skeleton + + + + The subdivision of the skeleton of either the pectoral or pelvic girdle. + https://orcid.org/0000-0002-6601-2165 + @@ -136051,8 +213859,18 @@ + A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle). + EMAPA:35494 + MA:0000688 bone of appendage girdle complex + + + + A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle). + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + @@ -136077,8 +213895,18 @@ + A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin. + EMAPA:35933 + MA:0000612 bone of pectoral complex + + + + A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin. + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + @@ -136103,8 +213931,19 @@ + A muscle of a pectoral girdle, pectoral fin or anterior limb. + AAO:0010687 + EMAPA:32624 + FMA:9621 + MA:0000615 pectoral complex muscle + + + + A muscle of a pectoral girdle, pectoral fin or anterior limb. + https://orcid.org/0000-0002-6601-2165 + @@ -136124,8 +213963,46 @@ + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. + FMA:23879 + SCTID:129140006 + VSAO:0000042 subdivision of skeleton + + + + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. + UBERONREF:0000003 + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + Skeletal element that forms around the notochord and is part of the vertebral column. + VHOG:0001143 + VSAO:0000184 + vertebral element + + + + + Skeletal element that forms around the notochord and is part of the vertebral column. + GO_REF:0000034 + VSAO:0000184 + http://dx.plos.org/10.1371/journal.pone.0051070 + https://github.com/obophenotype/uberon/issues/294 + @@ -136150,8 +214027,16 @@ + Any muscle organ that is part of either the head or the neck. + NCIT:C32716 craniocervical muscle + + + + Any muscle organ that is part of either the head or the neck. + http://orcid.org/0000-0002-6601-2165 + @@ -136182,8 +214067,146 @@ + A cartilage element that is part of a splanchnocranium. + EFO:0003689 + TAO:0001460 + ZFA:0001460 pharyngeal arch cartilage + + + + A cartilage element that is part of a splanchnocranium. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG]. + EFO:0003659 + TAO:0001272 + ZFA:0001272 + palatoquadrate arch + + + + + The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG]. + VHOG:0000511 + https://github.com/obophenotype/uberon/issues/153 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + EMAPA:32669 + VHOG:0000584 + vertebra cartilage element + + + + + The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + GO_REF:0000034 + VSAO:0000184 + http://dx.plos.org/10.1371/journal.pone.0051070 + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + EMAPA:32671 + VHOG:0000582 + vertebra pre-cartilage condensation + + + + + The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. + GO_REF:0000034 + VSAO:0000184 + http://dx.plos.org/10.1371/journal.pone.0051070 + http://orcid.org/0000-0002-6601-2165 + @@ -136215,8 +214238,17 @@ + A synovial joint that is part of a pectoral girdle region. + FMA:35243 + SCTID:303080001 synovial joint of pectoral girdle + + + + A synovial joint that is part of a pectoral girdle region. + OBOL:automatic + @@ -136224,8 +214256,16 @@ + Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis. + FMA:7491 nonsynovial joint + + + + Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis. + FMA:7491 + @@ -136239,8 +214279,16 @@ + Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. + FMA:7483 axial skeletal system + + + + Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. + https://orcid.org/0000-0002-6601-2165 + @@ -136254,8 +214302,59 @@ + Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. + FMA:302077 postcranial axial skeletal system + + + + Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. + https://github.com/obophenotype/uberon/issues/44 + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue. + BTO:0003751 + Wikipedia:Submucosal_glands + submucosal gland + + + + + Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue. + BTO:0003751 + Wikipedia:Submucosal_glands + @@ -136270,8 +214369,24 @@ + Subdivision of skull that consists of the facial bones. + EHDAA2:0002206 + EHDAA:8361 + EMAPA:18022 + FMA:53673 + MA:0000318 + Wikipedia:Facial_skeleton facial skeleton + + + + Subdivision of skull that consists of the facial bones. + MP:0005274 + Wikipedia:Facial_skeleton + http://www.bartleby.com/107/37.html + https://orcid.org/0000-0002-6601-2165 + @@ -136285,8 +214400,16 @@ + The skull can be divided into two: the neurocranium and the facial skeleton. + FMA:54964 primary subdivision of skull + + + + The skull can be divided into two: the neurocranium and the facial skeleton. + http://orcid.org/0000-0002-6601-2165 + @@ -136327,8 +214450,203 @@ + A bone that is part of a neurocranium [Automatically generated definition]. + EMAPA:35238 + MA:0001478 + SCTID:120229002 neurocranium bone + + + + A bone that is part of a neurocranium [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Synovial joint that articulates bones of upper and lower jaw. + joint connecting upper and lower jaws + + + + + Synovial joint that articulates bones of upper and lower jaw. + http://evolution.berkeley.edu/evolibrary/article/evograms_05 + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + A sphincter muscle that is part of the gastrointestinal system. + NCIT:C32669 + gastrointestinal sphincter + + + + + A sphincter muscle that is part of the gastrointestinal system. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A lamina propria that is part of a large intestine. + FMA:15654 + NCIT:C49298 + lamina propria of large intestine + + + + + A lamina propria that is part of a large intestine. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of a large intestine. + FMA:14971 + NCIT:C32927 + muscle layer of large intestine + + + + + A muscle layer that is part of a large intestine. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of a small intestine. + FMA:14932 + NCIT:C33569 + SCTID:362145004 + muscle layer of small intestine + + + + + A muscle layer that is part of a small intestine. + OBOL:automatic + @@ -136354,8 +214672,16 @@ + A multi cell part structure that is part of a central nervous system. + FMA:83143 central nervous system cell part cluster + + + + A multi cell part structure that is part of a central nervous system. + OBOL:automatic + @@ -136369,12 +214695,17 @@ - - - - + A subdivision of an anatomical system. + FMA:67509 + SCTID:91690000 organ system subdivision + + + + A subdivision of an anatomical system. + http://orcid.org/0000-0002-6601-2165 + @@ -136389,6 +214720,9 @@ + AAO:0010038 + EMAPA:18808 + FMA:49150 intra-ocular muscle @@ -136415,8 +214749,20 @@ + Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa. + BTO:0001823 + FMA:40878 + Wikipedia:Synovial_sheath + Alternate def: A synovial sheath is a layer of a tendon sheath containing tendons in the hand and foot. They lie internal to the fibrous tendon sheaths. An example is the common synovial sheath for the flexor tendons. [Wikipedia:Synovial_sheath] synovial membrane of synovial tendon sheath + + + + Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa. + FMA:45087 + Wikipedia:Synovial_sheath + @@ -136451,11 +214797,42 @@ + FMA:40877 fibrous membrane of synovial tendon sheath + + + + + + + + + + + + + + + + + The most anterior region of the braincase. Provides structural support for peripheral olfactory organ. + AAO:0000986 + ethmoid region + + + + + The most anterior region of the braincase. Provides structural support for peripheral olfactory organ. + UBERONREF:0000007 + http://palaeos.com/vertebrates/bones/braincase/ethmoid.html + + + + @@ -136472,8 +214849,17 @@ + Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints. + FMA:7484 + VSAO:0000306 appendicular skeletal system + + + + Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints. + https://orcid.org/0000-0002-6601-2165 + @@ -136487,8 +214873,20 @@ + The part of the trunk that is in the dorsum[cjm]. + EMAPA:35162 + FMA:25056 + MA:0000020 + Wikipedia:Human_back dorsal trunk + + + + The part of the trunk that is in the dorsum[cjm]. + UBERONREF:0000006 + Wikipedia:Human_back + @@ -136509,6 +214907,7 @@ + EHDAA2:0001845 embryonic skin basal layer @@ -136530,8 +214929,17 @@ + A blood vasculature that is part of a head. + TAO:0005297 + ZFA:0005297 cranial blood vasculature + + + + A blood vasculature that is part of a head. + OBOL:automatic + @@ -136545,6 +214953,8 @@ + FMA:54364 + SCTID:432899004 lumen of gastrointestinal system @@ -136583,8 +214993,18 @@ + An anatomical cavity that is part of a esophagus. + EMAPA:18380 + FMA:9398 + SCTID:322648002 lumen of esophagus + + + + An anatomical cavity that is part of a esophagus. + OBOL:automatic + @@ -136628,8 +215048,16 @@ + The collection of all skeletal elements in an individual limb or fin. + VSAO:0000301 paired limb/fin skeleton + + + + The collection of all skeletal elements in an individual limb or fin. + https://orcid.org/0000-0002-6601-2165 + @@ -136637,8 +215065,43 @@ + Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). + VSAO:0000006 + XAO:0004021 cell condensation + + + + Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000006 + http://dx.plos.org/10.1371/journal.pone.0051070 + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0002120 + future upper lip + @@ -136676,8 +215139,17 @@ + A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions. + EMAPA:32905 + NCIT:C114916 jaw region + + + + A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions. + http://orcid.org/0000-0002-6601-2165 + @@ -136692,11 +215164,45 @@ + EHDAA2:0001020 future lower lip + + + + + + + + + + + + + + + + + + + + + + Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species). + bone of upper jaw + + + + + Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species). + https://orcid.org/0000-0002-6601-2165 + + + + @@ -136730,8 +215236,16 @@ + An epithelium that develops_from a ectoderm and is part of a oral epithelium. + EHDAA2:0004137 oral epithelium from ectoderm + + + + An epithelium that develops_from a ectoderm and is part of a oral epithelium. + OBOL:automatic + @@ -136745,6 +215259,11 @@ + AAO:0000247 + EFO:0003511 + TAO:0000236 + XAO:0003269 + ZFA:0000236 jaw muscle @@ -136760,8 +215279,50 @@ + A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. subdivision of organism along main body axis + + + + A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly. + trunk vertebra + + + + + A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly. + UBERONREF:0000006 + @@ -136786,8 +215347,18 @@ + A cardiovascular system that is part of a conceptus. + EHDAA2:0000216 + FMA:305965 + NCIT:C34148 embryonic cardiovascular system + + + + A cardiovascular system that is part of a conceptus. + OBOL:automatic + @@ -136818,8 +215389,56 @@ + An anatomical space that is part of a bone of lower jaw. + AAO:0000273 lower jaw opening + + + + An anatomical space that is part of a bone of lower jaw. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that is part of a bone of upper jaw. + AAO:0000621 + upper jaw opening + + + + + An anatomical space that is part of a bone of upper jaw. + OBOL:automatic + @@ -136844,8 +215463,16 @@ + A neural nucleus that is part of the spinal cord. + FMA:77011 nucleus of spinal cord + + + + A neural nucleus that is part of the spinal cord. + http://orcid.org/0000-0002-6601-2165 + @@ -136870,8 +215497,15 @@ + A nerve that is part of a head. nerve of head region + + + + A nerve that is part of a head. + OBOL:automatic + @@ -136879,8 +215513,16 @@ + Ectodermal placode that does not develop into a component of the nervous system. non-neurogenic ectodermal placode + + + + Ectodermal placode that does not develop into a component of the nervous system. + PMID:11523831 + http://orcid.org/0000-0002-6601-2165 + @@ -136926,9 +215568,17 @@ - + An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart. + EHDAA2:0004149 + FMA:85125 atrioventricular region + + + + An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -136936,8 +215586,16 @@ + Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium. + FMA:20107 irregular connective tissue + + + + Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium. + FMA:20107 + @@ -136967,8 +215625,19 @@ + Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. + FMA:20109 + NCIT:C32882 + Wikipedia:Dense_irregular_connective_tissue dense irregular connective tissue + + + + Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. + FMA:20109 + Wikipedia:Dense_irregular_connective_tissue + @@ -136994,8 +215663,18 @@ + Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets. + AAO:0000121 + NCIT:C32450 + Wikipedia:Dense_connective_tissue dense connective tissue + + + + Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets. + Wikipedia:Dense_connective_tissue + @@ -137003,6 +215682,8 @@ + FMA:75634 + SCTID:363130003 fibrous connective tissue @@ -137012,8 +215693,18 @@ + Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. + FMA:19783 + NCIT:C33007 + Wikipedia:Loose_connective_tissue loose connective tissue + + + + Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. + FMA:19783 + @@ -137038,8 +215729,15 @@ + An acinus that is part of a exocrine gland. acinus of exocrine gland + + + + An acinus that is part of a exocrine gland. + OBOL:automatic + @@ -137059,6 +215757,10 @@ + FMA:63212 + MESH:D024022 + NCIT:C32339 + NIF_Subcellular:sao7547390221 collection of collagen fibrils @@ -137092,8 +215794,15 @@ + The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity. aorta collagen fibril + + + + The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity. + MP:0011640 + @@ -137125,8 +215834,15 @@ + The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity. pulmonary collagen fibril + + + + The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity. + MP:0011641 + @@ -137151,8 +215867,15 @@ + The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity. bone collagen fibril + + + + The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity. + MP:0011642 + @@ -137183,8 +215906,15 @@ + The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity. tendon collagen fibril + + + + The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity. + MP:0011643 + @@ -137216,8 +215946,55 @@ + The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity. corneal stroma collagen fibril + + + + The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity. + MP:0011650 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of a wall of esophagus. + FMA:62998 + muscle layer of esophagus + + + + + A muscle layer that is part of a wall of esophagus. + OBOL:automatic + @@ -137256,8 +216033,16 @@ + Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris. + SCTID:280656002 anterior uvea + + + + Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris. + MP:0005194 + @@ -137284,8 +216069,18 @@ + Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous. + FMA:9726 + NCIT:C32527 + Wikipedia:Epimysium epimysium + + + + Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous. + Wikipedia:Epimysium + @@ -137317,8 +216112,17 @@ + Masses of developing blood cells attached to endothelium in the yolk sac. + EHDAA2:0000177 + EMAPA:16115 yolk sac blood island + + + + Masses of developing blood cells attached to endothelium in the yolk sac. + MP:0011204 + @@ -137343,8 +216147,91 @@ + A region of the stomach that is lined with glandular epithelium. + EMAPA:17623 + MA:0001613 + NCIT:C77661 + SCTID:27633001 stomach glandular region + + + + A region of the stomach that is lined with glandular epithelium. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic vein that is part of a left lobe of liver. + FMA:14339 + MA:0003032 + SCTID:55188000 + left hepatic vein + + + + + A hepatic vein that is part of a left lobe of liver. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic vein that is part of a right lobe of liver. + FMA:14338 + MA:0003034 + SCTID:18135006 + right hepatic vein + + + + + A hepatic vein that is part of a right lobe of liver. + OBOL:automatic + @@ -137358,8 +216245,19 @@ + The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. + EHDAA2:0004731 + Wikipedia:Coelom coelom + + + + The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. + UBERON:cjm + Wikipedia:Body_cavity + Wikipedia:Coelom + @@ -137384,8 +216282,73 @@ + The cavity within a myotome. + EMAPA:31134 + VHOG:0001283 myocoele + + + + The cavity within a myotome. + http://medical-dictionary.thefreedictionary.com/myocoele + + + + + + + + + + + + + + + + + + + + + + + + + + + Any bone that is part of a palate. + NCIT:C33248 + palate bone + + + + + Any bone that is part of a palate. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + palatal part of dermatocranium + @@ -137394,8 +216357,18 @@ + Bone that forms as a replacement of another structural tissue. + AAO:0010768 + TAO:0001637 + ZFA:0001628 replacement bone + + + + Bone that forms as a replacement of another structural tissue. + ZFA:0001628 + @@ -137415,8 +216388,17 @@ + An anatomical cavity that is part of a bronchus. + FMA:62646 + SCTID:199401001 bronchial lumen + + + + An anatomical cavity that is part of a bronchus. + OBOL:automatic + @@ -137447,8 +216429,17 @@ + A primordium that has the potential to develop into a stomach. + EFO:0002580 + NCIT:C34305 stomach primordium + + + + A primordium that has the potential to develop into a stomach. + OBOL:automatic + @@ -137473,8 +216464,17 @@ + A zone of skin that is part of a craniocervical region. + MA:0000574 + NCIT:C12294 head or neck skin + + + + A zone of skin that is part of a craniocervical region. + OBOL:automatic + @@ -137499,8 +216499,17 @@ + The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins. + MA:0002194 + NCIT:C53062 phrenic vein + + + + The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins. + ncithesaurus:Phrenic_Vein + @@ -137525,8 +216534,17 @@ + An artery that originates from the abdominal aorta. + SCTID:281470000 abdominal aorta artery + + + + An artery that originates from the abdominal aorta. + Wikipedia:Abdominal_aorta#Branches + https://orcid.org/0000-0002-6601-2165 + @@ -137540,8 +216558,16 @@ + An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]. + Wikipedia:Columnar_epithelium columnar epithelium + + + + An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]. + Wikipedia:Columnar_epithelium + @@ -137561,8 +216587,16 @@ + Epithelium that derives from the mesoderm. [Automatically generated definition]. + FMA:86452 meso-epithelium + + + + Epithelium that derives from the mesoderm. [Automatically generated definition]. + OBOL:automatic + @@ -137582,8 +216616,17 @@ + One of five swellings formed during the development of the face. + FMA:293103 + SCTID:89066004 embryonic facial prominence + + + + One of five swellings formed during the development of the face. + http://www.indiana.edu/~anat550/hnanim/face/face.html + @@ -137603,8 +216646,16 @@ + An artery of the neck. + NCIT:C52850 cervical artery + + + + An artery of the neck. + https://orcid.org/0000-0002-6601-2165 + @@ -137635,9 +216686,18 @@ - + The deep cervical artery (Profunda cervicalis) is an artery of the neck. + FMA:10659 + SCTID:244223002 + Wikipedia:Deep_cervical_artery deep cervical artery + + + + The deep cervical artery (Profunda cervicalis) is an artery of the neck. + Wikipedia:Deep_cervical_artery + @@ -137645,9 +216705,19 @@ - + The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery. + FMA:10664 + MA:0001936 + SCTID:244224008 + Wikipedia:Transverse_cervical_artery transverse cervical artery + + + + The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery. + Wikipedia:Transverse_cervical_artery + @@ -137673,8 +216743,68 @@ + A bone element that is part of a jaw region. + EMAPA:35453 + MA:0003130 + SCTID:369003004 bone of jaw + + + + A bone element that is part of a jaw region. + OBOL:automatic + + + + + + + + + + + + + + + EHDAA2:0004588 + internal anal region + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of an intestine. + FMA:15697 + muscle layer of intestine + + + + + A muscle layer that is part of an intestine. + OBOL:automatic + @@ -137715,9 +216845,20 @@ - + A layer of tissue between the muscularis and serosa. + FMA:45636 + NCIT:C94494 + SCTID:2255006 + Wikipedia:Subserosa + Contains nerves, blood vessels, lymphatics and lymph nodes subserosa + + + + A layer of tissue between the muscularis and serosa. + Wikipedia:Subserosa + @@ -137743,7 +216884,7 @@ - + MA:0001802 respiratory system arterial smooth muscle @@ -137770,9 +216911,68 @@ - + A smooth muscle tissue that is part of a respiratory system venous blood vessel. + MA:0001812 respiratory system venous smooth muscle + + + + A smooth muscle tissue that is part of a respiratory system venous blood vessel. + OBOL:automatic + + + + + + + + + + + + + + + A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]. + FMA:67296 + MESH:D008871 + NCIT:C33112 + Wikipedia:Microvillus + layer of microvilli + + + + + A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]. + GO:0005902 + Wikipedia:Microvillus + + + + + + + + + + + + + + + A microvillus layer that is striated and found in the intestine. + FMA:70978 + NCIT:C33634 + striated border microvillus layer + + + + + A microvillus layer that is striated and found in the intestine. + http://medical-dictionary.thefreedictionary.com/striated+border + http://orcid.org/0000-0002-6601-2165 + @@ -137804,8 +217004,18 @@ + Blood-forming tissue, consisting of reticular fibers and cells. + CALOHA:TS-2142 + FMA:14073 + NCIT:C13051 hematopoietic tissue + + + + Blood-forming tissue, consisting of reticular fibers and cells. + http://encyclopedia2.thefreedictionary.com/hematopoietic+tissue + @@ -137833,8 +217043,137 @@ + The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth. + FMA:58102 + SCTID:361318005 + Wikipedia:Fibrous_tunic_of_eyeball tunica fibrosa of eyeball + + + + The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth. + Wikipedia:Fibrous_tunic_of_eyeball + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that is enclosed by a cloaca. + TAO:0000330 + ZFA:0000330 + cloacal lumen + + + + + An anatomical space that is enclosed by a cloaca. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives. + cloacal vent + + + + + The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that is enclosed by a terminal part of digestive tract. + lumen of terminal part of digestive tract + + + + + An anatomical space that is enclosed by a terminal part of digestive tract. + OBOL:automatic + @@ -137859,6 +217198,9 @@ + EHDAA2:0000472 + EMAPA:16054 + VHOG:0000767 extraembryonic cavity @@ -137885,8 +217227,32 @@ + An anatomical space with no opening to another space or to the exterior. + AEO:0000222 enclosed anatomical space + + + + An anatomical space with no opening to another space or to the exterior. + AEO:0000222 + + + + + + + + + + + + + + + EHDAA2:0004589 + external anal region + @@ -137923,8 +217289,384 @@ + The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle. + FMA:24139 skeleton of pectoral complex + + + + The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle. + https://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + The posterior region of the neck, including the suboccipital region. + BTO:0000957 + FMA:24189 + SCTID:182326009 + SCTID:304036007 + dorsal part of neck + + + + + The posterior region of the neck, including the suboccipital region. + MP:0012723 + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a cloaca. + cloacal gland + + + + + A gland that is part of a cloaca. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a cloaca [Automatically generated definition]. + cloacal mucosa + + + + + A mucosa that is part of a cloaca [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a cloaca. + EMAPA:27577 + EMAPA:36070 + ZFA:0005783 + cloacal epithelium + + + + + An epithelium that is part of a cloaca. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a cloaca [Automatically generated definition]. + submucosa of cloaca + + + + + A submucosa that is part of a cloaca [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A serous membrane that is part of a cloaca [Automatically generated definition]. + serosa of cloaca + + + + + A serous membrane that is part of a cloaca [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + cloacal villus + + + + + + + + + + + + + + + + + + + + + + + + + + A muscular coat that is part of a cloaca. + muscle layer of cloaca + + + + + A muscular coat that is part of a cloaca. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscular coat that is part of a duodenum. + FMA:14944 + SCTID:362147007 + muscle layer of duodenum + + + + + A muscular coat that is part of a duodenum. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscular coat that is part of a colon. + EMAPA:27383 + FMA:14986 + MA:0003198 + SCTID:362158003 + muscle layer of colon + + + + + A muscular coat that is part of a colon. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A muscular coat that is part of a anal canal. + FMA:15708 + SCTID:362171000 + muscle layer of anal canal + + + + + A muscular coat that is part of a anal canal. + OBOL:automatic + @@ -137949,8 +217691,108 @@ + An adventitia that is part of a esophagus. + FMA:63006 + SCTID:85950006 adventitia of esophagus + + + + An adventitia that is part of a esophagus. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical junction that connects a stomach and connects a duodenum. + FMA:17046 + SCTID:264014000 + gastroduodenal junction + + + + + An anatomical junction that connects a stomach and connects a duodenum. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a gastroduodenal junction. + BTO:0005415 + mucosa of gastroduodenal junction + + + + + A mucosa that is part of a gastroduodenal junction. + OBOL:automatic + @@ -137970,8 +217812,16 @@ + A vein that is part of a abdomen. + SCTID:281473003 vein of abdomen + + + + A vein that is part of a abdomen. + OBOL:automatic + @@ -137991,8 +217841,17 @@ + The part of the venous system that drains the lungs[Kardong]. + Wikipedia:Pulmonary_venous_system pulmonary venous system + + + + The part of the venous system that drains the lungs[Kardong]. + ISBN:0073040584 + Wikipedia:Pulmonary_venous_system + @@ -138023,8 +217882,16 @@ + A vein that drains a lip. + SCTID:367664002 vein of lip + + + + A vein that drains a lip. + OBOL:automatic + @@ -138049,8 +217916,86 @@ + Any vein within the general circulation that transports blood back to the right atrium of the heart. + FMA:66644 + NCIT:C33719 + SCTID:244389004 systemic vein + + + + Any vein within the general circulation that transports blood back to the right atrium of the heart. + ncithesaurus:Systemic_Vein + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a foregut-midgut junction. + EHDAA2:0000574 + EMAPA:17065 + foregut-midgut junction gland + + + + + A gland that is part of a foregut-midgut junction. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A bodily secretion that is produced by a gland of anal sac. + anal sac gland secretion + + + + + A bodily secretion that is produced by a gland of anal sac. + OBOL:automatic + @@ -138081,8 +218026,17 @@ + The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. + FMA:86279 serous acinus + + + + The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. + http://orcid.org/0000-0002-6601-2165 + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -138113,8 +218067,21 @@ + Anatomical cavity that is the lumen of the skull and contains the brain. + FMA:9644 + MA:0003061 + NCIT:C77638 + SCTID:264452006 + Wikipedia:Cranial_cavity + neuronames:2806 cranial cavity + + + + Anatomical cavity that is the lumen of the skull and contains the brain. + UBERON:cjm + @@ -138135,8 +218102,260 @@ + A blood vessel endothelium that is part of a lung [Automatically generated definition]. + BTO:0004128 + CALOHA:TS-0573 lung endothelium + + + + A blood vessel endothelium that is part of a lung [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A sphincter muscle that is part of a cloaca. + NCIT:C34129 + the muscles of the cloacal sphincter specialise into the perineal muscles in mammals (Gegenbaur, 1883; Popowsky, 1899; Nishi, 1938). + cloacal sphincter + + + + + A sphincter muscle that is part of a cloaca. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A caudal vertebra endochondral element that is composed primarily of cartilage tissue. + EHDAA2:0000260 + EMAPA:18044 + caudal vertebra cartilage element + + + + + A caudal vertebra endochondral element that is composed primarily of cartilage tissue. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + EMAPA:18045 + caudal vertebra pre-cartilage condensation + + + + + A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A cervical vertebra endochondral element that is composed primarily of cartilage tissue. + EHDAA2:0000240 + cervical vertebra cartilage element + + + + + A cervical vertebra endochondral element that is composed primarily of cartilage tissue. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + cervical vertebra pre-cartilage condensation + + + + + A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A thoracic vertebra endochondral element that is composed primarily of cartilage tissue. + EHDAA2:0002014 + thoracic vertebra cartilage element + + + + + A thoracic vertebra endochondral element that is composed primarily of cartilage tissue. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + thoracic vertebra pre-cartilage condensation + + + + + A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation. + OBOL:automatic + @@ -138161,8 +218380,15 @@ + The space that surrounds an organism. space surrounding organism + + + + The space that surrounds an organism. + https://orcid.org/0000-0002-6601-2165 + @@ -138226,8 +218452,57 @@ + The anatomical space that is enclosed by a stomach. + EMAPA:18395 + FMA:14585 stomach lumen + + + + The anatomical space that is enclosed by a stomach. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a intestinal villus. + FMA:63587 + epithelium of intestinal villus + + + + + An epithelium that is part of a intestinal villus. + OBOL:automatic + @@ -138252,8 +218527,19 @@ + Anatomical space that is an opening in a bone of the skull. + FMA:53165 + SCTID:276742007 + Wikipedia:Foramina_of_the_skull foramen of skull + + + + Anatomical space that is an opening in a bone of the skull. + TAO:curator + http://orcid.org/0000-0002-6601-2165 + @@ -138274,11 +218560,17 @@ - - - + An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. + FMA:9338 anatomical conduit space + + + + An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. + FMA:9338 + http://orcid.org/0000-0002-6601-2165 + @@ -138304,8 +218596,81 @@ + Vascular endothelium found in blood vessels of the blood-brain-barrier. + BTO:0001852 + BTO:0003248 + CALOHA:TS-0092 brain endothelium + + + + Vascular endothelium found in blood vessels of the blood-brain-barrier. + CALOHA:TS-0092 + + + + + + + + + + + + + + + + + + + + + Vascular endothelium found in colon blood vessels. + CALOHA:TS-0162 + colon endothelium + + + + + Vascular endothelium found in colon blood vessels. + CALOHA:TS-0162 + + + + + + + + + + + + + + + + + + + + + + + + + + Epithelium lining the exocrine pancreas. + CALOHA:TS-2108 + exocrine pancreas epithelium + + + + + Epithelium lining the exocrine pancreas. + CALOHA:TS-2108 + @@ -138340,8 +218705,17 @@ + Musculature of the head and neck, spine, and ribs. + EHDAA2:0000159 + EMAPA:18166 axial musculature + + + + Musculature of the head and neck, spine, and ribs. + HP:0003327 + @@ -138355,8 +218729,15 @@ + A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. main body axis + + + + A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. + https://orcid.org/0000-0002-6601-2165 + @@ -138370,8 +218751,18 @@ + The region of the organism associated with the visceral organs. + AEO:0000103 + BTO:0001489 + FMA:231424 body proper + + + + The region of the organism associated with the visceral organs. + AEO:0000103 + @@ -138397,8 +218788,17 @@ + A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily. + FMA:293127 + NCIT:C34230 notochordal canal + + + + A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily. + http://medical-dictionary.thefreedictionary.com/notochordal+canal + @@ -138433,8 +218833,17 @@ + Fluid contained within the notochordal canal. + Distinct feature of coelocanths notochordal fluid + + + + Fluid contained within the notochordal canal. + http://animaldiversity.org/accounts/Latimeria_chalumnae/ + http://orcid.org/0000-0002-6601-2165 + @@ -138459,8 +218868,16 @@ + An organ component layer that is part of a integumental system. + SCTID:314820002 integumentary system layer + + + + An organ component layer that is part of a integumental system. + OBOL:automatic + @@ -138485,8 +218902,16 @@ + A blood that is part of a artery. + FMA:83066 arterial blood + + + + A blood that is part of a artery. + OBOL:automatic + @@ -138511,8 +218936,16 @@ + A blood that is part of a vein. + FMA:83067 venous blood + + + + A blood that is part of a vein. + OBOL:automatic + @@ -138537,8 +218970,17 @@ + A blood that is part of a capillary. + FMA:263901 + NCIT:C32212 capillary blood + + + + A blood that is part of a capillary. + OBOL:automatic + @@ -138563,8 +219005,16 @@ + Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements. + SCTID:272627002 digestive system element + + + + Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements. + http://orcid.org/0000-0002-6601-2165 + @@ -138572,8 +219022,19 @@ + Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart. + EMAPA:36460 + SCTID:304066000 + Wikipedia:Great_vessels + Groupings may vary - typically pulmonary vessels and aorta and vena cavae great vessel of heart + + + + Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart. + Wikipedia:Great_vessels + @@ -138593,8 +219054,18 @@ + Mesenchyme that develops_from the neural crest[Automatically generated definition]. + EMAPA:32735 + FMA:293883 mesenchyme derived from neural crest + + + + Mesenchyme that develops_from the neural crest[Automatically generated definition]. + OBOL:automatic + https://github.com/obophenotype/uberon/issues/248 + @@ -138625,8 +219096,15 @@ + Muscle that is part of the respiratory system. respiratory muscle + + + + Muscle that is part of the respiratory system. + http://orcid.org/0000-0002-6601-2165 + @@ -138657,8 +219135,50 @@ + An anatomical space that is enclosed by a sinusoid. + FMA:63133 sinusoidal space + + + + An anatomical space that is enclosed by a sinusoid. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A sinusoidal space that is part of a hepatic sinusoid. + FMA:262090 + hepatic sinusoidal space + + + + + A sinusoidal space that is part of a hepatic sinusoid. + OBOL:automatic + @@ -138683,8 +219203,18 @@ + A part of the body present only in a specific gender. + AEO:0000174 + WBbt:0005752 sex-specific anatomical structure + + + + A part of the body present only in a specific gender. + AEO:0000174 + AEO:JB + @@ -138709,8 +219239,17 @@ + A part of the body present only in females. + AEO:0000176 female anatomical structure + + + + A part of the body present only in females. + AEO:0000176 + AEO:JB + @@ -138749,8 +219288,20 @@ + Subcutaneous adipose tissue that is located in the peritoneal cavity. + BTO:0004041 + CALOHA:TS-2405 visceral abdominal adipose tissue + + + + Subcutaneous adipose tissue that is located in the peritoneal cavity. + CALOHA:paula + MGI:csmith + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/259 + @@ -138774,8 +219325,19 @@ + Subcutaneous adipose tissue that is located in the abdominal region. + CALOHA:TS-2406 subcutaneous abdominal adipose tissue + + + + Subcutaneous adipose tissue that is located in the abdominal region. + CALOHA:paula + MGI:csmith + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/259 + @@ -138795,9 +219357,19 @@ - + Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. + EHDAA2:0002013 + FMA:77169 + Wikipedia:Thoracic_skeleton thoracic skeleton + + + + Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. + Wikipedia:Rib_cage + https://orcid.org/0000-0002-6601-2165 + @@ -138822,9 +219394,17 @@ - + A ventral horn of spinal cord that is part of a thoracic spinal cord. + BIRNLEX:1410 + SCTID:367876000 thoracic spinal cord ventral horn + + + + A ventral horn of spinal cord that is part of a thoracic spinal cord. + OBOL:automatic + @@ -138849,9 +219429,17 @@ - + A gray matter of spinal cord that is part of a cervical spinal cord. + BIRNLEX:1521 + SCTID:362438009 cervical spinal cord gray matter + + + + A gray matter of spinal cord that is part of a cervical spinal cord. + OBOL:automatic + @@ -138876,9 +219464,17 @@ - + A ventral horn of spinal cord that is part of a cervical spinal cord. + BIRNLEX:1680 + SCTID:174363005 cervical spinal cord ventral horn + + + + A ventral horn of spinal cord that is part of a cervical spinal cord. + OBOL:automatic + @@ -138903,9 +219499,100 @@ - + A gray matter of spinal cord that is part of a thoracic spinal cord. + BIRNLEX:980 + SCTID:362441000 thoracic spinal cord gray matter + + + + A gray matter of spinal cord that is part of a thoracic spinal cord. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a frontonasal prominence. + EHDAA2:0004108 + EMAPA:32918 + frontonasal process epithelium + + + + + An epithelium that is part of a frontonasal prominence. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A unilaminar epithelium that develops_from a ectoderm and is part of a anal region. + EHDAA2:0004019 + EMAPA:25040 + anal membrane ectodermal component + + + + + A unilaminar epithelium that develops_from a ectoderm and is part of a anal region. + OBOL:automatic + @@ -138936,8 +219623,17 @@ + An anatomical space that is enclosed by a pleuroperitoneal canal. + EHDAA2:0004736 + EMAPA:25034 pleuroperitoneal canal lumen + + + + An anatomical space that is enclosed by a pleuroperitoneal canal. + OBOL:automatic + @@ -138972,9 +219668,59 @@ - + A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory. + NCIT:C32828 + UMLS:C1512857 + Wikipedia:Interlobular_ducts interlobular duct + + + + A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory. + ncithesaurus:Interlobular_Duct + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells. + FMA:86278 + mucous acinus + + + + + The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells. + http://orcid.org/0000-0002-6601-2165 + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -138999,9 +219745,16 @@ - + A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular. + SCTID:205214009 intralobular duct + + + + A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular. + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -139036,8 +219789,15 @@ + A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory. interlobar duct + + + + A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory. + http://www.siumed.edu/~dking2/intro/glands.htm + @@ -139062,8 +219822,17 @@ + A neuromere that is part of the presumptive midbrain. + EHDAA2:0004352 + FMA:61997 midbrain neuromere + + + + A neuromere that is part of the presumptive midbrain. + http://orcid.org/0000-0002-6601-2165 + @@ -139088,8 +219857,51 @@ + A neuromere that is part of the presumptive spinal cord. + TAO:0001332 + ZFA:0001332 spinal neuromere + + + + A neuromere that is part of the presumptive spinal cord. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any muscle organ that is part of a cloaca. + cloacal muscle + + + + + Any muscle organ that is part of a cloaca. + OBOL:automatic + @@ -139114,8 +219926,16 @@ + Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin. + FMA:71296 musculature of pectoral complex + + + + Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin. + OBOL:automatic + @@ -139140,8 +219960,15 @@ + Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin). pectoral appendage muscle + + + + Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin). + OBOL:automatic + @@ -139208,9 +220035,34 @@ - + A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles). + AAO:0011099 + BTO:0001103 + CALOHA:TS-0933 + EFO:0000888 + EHDAA:5035 + EHDAA:5043 + EHDAA:5978 + EHDAA:5984 + EMAPA:35988 + EV:0100377 + GAID:141 + MA:0003148 + MAT:0000302 + MESH:D018482 + MIAA:0000302 + TAO:0005277 + VHOG:0000319 + XAO:0000174 + ZFA:0005277 skeletal muscle organ, vertebrate + + + + A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles). + GOC:dos + @@ -139241,8 +220093,19 @@ + A portion of tissue that will develop into vasculature. + EFO:0003708 + TAO:0005076 + ZFA:0005076 primordial vasculature + + + + A portion of tissue that will develop into vasculature. + ZFA:0005076 + ZFA:curator + @@ -139256,8 +220119,138 @@ + One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites. + EFO:0003664 + TAO:0001285 + XAO:0004075 + ZFA:0001285 intersomitic vessel + + + + One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites. + MGI:anna + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vertebral endochondral element in the cervical region of the vertebral column. + cervical vertebra endochondral element + + + + + A vertebral endochondral element in the cervical region of the vertebral column. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vertebral endochondral element in the thoracic region of the vertebral column. + thoracic vertebra endochondral element + + + + + A vertebral endochondral element in the thoracic region of the vertebral column. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + A sphenoid bone or its cartilage or pre-cartilage precursor. + sphenoid endochondral element + + + + + A sphenoid bone or its cartilage or pre-cartilage precursor. + https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern + @@ -139271,6 +220264,7 @@ + FMA:83105 subepicardial layer of epicardium @@ -139325,8 +220319,16 @@ + Visceral intrapericardial fat contiguous with the myocardial surface. + FMA:9871 epicardial fat + + + + Visceral intrapericardial fat contiguous with the myocardial surface. + DOI:10.5935/abc.20130138 + @@ -139351,8 +220353,16 @@ + A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands. gland of ocular region + + + + A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands. + http://orcid.org/0000-0002-6601-2165 + https://github.com/obophenotype/uberon/issues/614 + @@ -139377,8 +220387,16 @@ + An eye consisting of multiple light-sensing organs. multi-unit eye + + + + An eye consisting of multiple light-sensing organs. + PMID:21062451 + http://orcid.org/0000-0002-6601-2165 + @@ -139413,8 +220431,18 @@ + A region of somite adjacent to presomitic mesoderm. + TAO:0001462 + XAO:0004074 + ZFA:0001462 somite border + + + + A region of somite adjacent to presomitic mesoderm. + http://orcid.org/0000-0002-6601-2165 + @@ -139439,8 +220467,17 @@ + Epithelium located in the intersomitic region. + XAO:0004077 somite boundary epithelium + + + + Epithelium located in the intersomitic region. + XAO:0004077 + XAO:EJS + @@ -139448,8 +220485,19 @@ + An anatomical group whose component structures share a common function. + AEO:0000093 non-connected functional system + + + + An anatomical group whose component structures share a common function. + AEO:0000093 + AEO:JB + FBC:DOS + FBbt:00007278 + @@ -139474,8 +220522,16 @@ + A non-connected functional system that is composed primarily of a gland. + EHDAA2:0002223 glandular system + + + + A non-connected functional system that is composed primarily of a gland. + OBOL:automatic + @@ -139506,8 +220562,15 @@ + Any structure that is placed on one side of the left-right axis of a bilaterian. lateral structure + + + + Any structure that is placed on one side of the left-right axis of a bilaterian. + http://orcid.org/0000-0002-6601-2165 + @@ -139527,8 +220590,85 @@ + A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. circulatory organ + + + + A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + A pancreatic lobule that is in_the_left_side_of a exocrine pancreas. + MA:0000722 + pancreas left lobe + + + + + A pancreatic lobule that is in_the_left_side_of a exocrine pancreas. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A pancreatic lobule that is in_the_right_side_of a exocrine pancreas. + MA:0000723 + pancreas right lobe + + + + + A pancreatic lobule that is in_the_right_side_of a exocrine pancreas. + OBOL:automatic + @@ -139553,8 +220693,16 @@ + A basement membrane of epithelium that is part of a respiratory system. + MA:0001815 respiratory system basement membrane + + + + A basement membrane of epithelium that is part of a respiratory system. + OBOL:automatic + @@ -139568,16 +220716,207 @@ - + MA:0002449 heart plus pericardium + + + + + + + + + + + The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery. + FMA:14772 + MA:0003095 + SCTID:244262006 + Wikipedia:Hepatic_artery_proper + proper hepatic artery + + + + + The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery. + Wikipedia:Hepatic_artery_proper + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic artery that is part of a left lobe of liver. + FMA:14779 + MA:0003096 + left hepatic artery + + + + + A hepatic artery that is part of a left lobe of liver. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A hepatic artery that is part of a right lobe of liver. + FMA:14778 + MA:0003097 + right hepatic artery + + + + + A hepatic artery that is part of a right lobe of liver. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla. + MA:0003108 + choledocho-duodenal junction + + + + + Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla. + http://medical-dictionary.thefreedictionary.com/choledochoduodenal+junction + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a anal canal. + EMAPA:18835 + FMA:17511 + anal canal epithelium + + + + + An epithelium that is part of a anal canal. + OBOL:automatic + + + + + FMA:62798 heterogeneous tissue @@ -139604,8 +220943,52 @@ + A smooth muscle tissue that is part of a hypodermis. + FMA:77862 smooth muscle layer in fatty layer of subcutaneous tissue + + + + A smooth muscle tissue that is part of a hypodermis. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a liver. + EMAPA:35498 + MA:0003137 + liver blood vessel + + + + + A blood vessel that is part of a liver. + OBOL:automatic + @@ -139631,8 +221014,17 @@ + An epithelium that is part of a camera-type eye. + EMAPA:35957 + MA:0003162 eye epithelium + + + + An epithelium that is part of a camera-type eye. + OBOL:automatic + @@ -139657,8 +221049,53 @@ + An epithelium that is part of a foregut. + EMAPA:32922 + MA:0003204 foregut epithelium + + + + An epithelium that is part of a foregut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A lamina propria that is part of a duodenum. + EMAPA:27255 + FMA:15972 + MA:0003209 + duodenum lamina propria + + + + + A lamina propria that is part of a duodenum. + OBOL:automatic + @@ -139678,9 +221115,16 @@ - + A capillary that is part of a lung. + FMA:14121 pulmonary capillary + + + + A capillary that is part of a lung. + OBOL:automatic + @@ -139715,8 +221159,51 @@ + A hole in the diaphragm through which the esophagus passes. + FMA:58289 esophageal hiatus + + + + A hole in the diaphragm through which the esophagus passes. + HP:0002036 + + + + + + + + + + + + + + + + + + + + + + + + + + + A stroma that is part of a liver. + FMA:17553 + liver stroma + + + + + A stroma that is part of a liver. + OBOL:automatic + @@ -139747,8 +221234,22 @@ + Is the sensory system for the sense of hearing. + EMAPA:36002 + FMA:7192 + MA:0002443 + NCIT:C12889 + NLXANAT:090817 + Wikipedia:Auditory_system + neuronames:2888 auditory system + + + + Is the sensory system for the sense of hearing. + NLXANAT:090817 + @@ -139773,8 +221274,52 @@ + Luminal space of the right ventricle of the heart. + EMAPA:26047 + FMA:9291 cavity of right ventricle + + + + Luminal space of the right ventricle of the heart. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that is part of a duodenum. + EMAPA:19080 + FMA:14589 + lumen of duodenum + + + + + An anatomical space that is part of a duodenum. + OBOL:automatic + @@ -139799,8 +221344,17 @@ + Luminal space of the left atrium of the heart. + EMAPA:26011 + FMA:9465 cavity of left atrium + + + + Luminal space of the left atrium of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -139825,8 +221379,17 @@ + Luminal space of the left ventricle of the heart. + EMAPA:26038 + FMA:9466 cavity of left ventricle + + + + Luminal space of the left ventricle of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -139851,8 +221414,17 @@ + Luminal space of the right atrium of the heart. + EMAPA:26020 + FMA:11359 cavity of right atrium + + + + Luminal space of the right atrium of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -139883,8 +221455,18 @@ + The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches. + TAO:0001379 + ZFA:0001379 pharyngeal ectoderm + + + + The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches. + PMID:23020903 + http://orcid.org/0000-0002-6601-2165 + @@ -139909,8 +221491,16 @@ + A layer of of the central nervous system that is part of gray matter. + FMA:83142 central nervous system gray matter layer + + + + A layer of of the central nervous system that is part of gray matter. + http://orcid.org/0000-0002-6601-2165 + @@ -139929,6 +221519,93 @@ + + + + + + + + + + + + + + + + + + + + + + Mucus produced in the respiratory tract. + NCIT:C93171 + UMLS:C0225378 + phlegm + + + + + Mucus produced in the respiratory tract. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm). + respiratory system mucus + + + + + Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm). + Wikipedia:Nasal_mucus#Respiratory_system + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + An roughly circular indentation in a surface. + AEO:0000204 + pit + + + + + An roughly circular indentation in a surface. + AEO:0000204 + AEO:JB + + + + @@ -139951,11 +221628,54 @@ + FMA:68861 + Wikipedia:Rexed_laminae + http://neurolex.org/wiki/Category:Rexed_spinal_cord_parcellation_scheme_region lamina of gray matter of spinal cord + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The dorsal region of the optic cup that gives rise to the dorsal part of the retina. + dorsal part of optic cup + + + + + The dorsal region of the optic cup that gives rise to the dorsal part of the retina. + http://orcid.org/0000-0002-6601-2165 + + + + @@ -139989,8 +221709,15 @@ + Primordium that develops into the central nervous system. future central nervous system + + + + Primordium that develops into the central nervous system. + http://orcid.org/0000-0002-6601-2165 + @@ -140021,8 +221748,84 @@ + Primordium that develops into the nervous system. + AAO:0000477 future nervous system + + + + Primordium that develops into the nervous system. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Epithelium lining the distalmost portion of the digestive tract. + BTO:0005445 + WBbt:0005800 + epithelium of terminal part of digestive tract + + + + + Epithelium lining the distalmost portion of the digestive tract. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Any muscle tissue of the distalmost portion of the digestive tract. + muscle tissue of terminal part of digestive tract + + + + + Any muscle tissue of the distalmost portion of the digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -140048,8 +221851,19 @@ + The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism. + AEO:0000195 + EHDAA2:0000003 + EMAPA:16042 entire extraembryonic component + + + + The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism. + AEO:0000195 + AEO:JB + @@ -140057,8 +221871,17 @@ + An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development. + AEO:0000132 transitional anatomical structure + + + + An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development. + AEO:0000132 + AEO:JB + @@ -140083,8 +221906,17 @@ + A mesenchyme-derived anatomical entity undergoing a transtion to become another structure. + AEO:0001016 developing mesenchymal structure + + + + A mesenchyme-derived anatomical entity undergoing a transtion to become another structure. + AEO:0001016 + AEO:JB + @@ -140104,8 +221936,86 @@ + A viscus that is part of a abdomen. + FMA:32413 + FMA:67355 abdominal viscera + + + + A viscus that is part of a abdomen. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of the rectum. + FMA:15035 + muscle layer of rectum + + + + + A muscle layer that is part of the rectum. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any portion of smooth muscle tissue that is part of the rectum. + rectum smooth muscle tissue + + + + + Any portion of smooth muscle tissue that is part of the rectum. + http://orcid.org/0000-0002-6601-2165 + @@ -140130,11 +222040,55 @@ + FMA:83521 fibrocollagenous connective tissue + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx). + caudal vertebra endochondral element + + + + + Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx). + http://orcid.org/0000-0002-6601-2165 + + + + @@ -140156,8 +222110,87 @@ + A zone of skin that is part of a lower lip. + FMA:24767 + SCTID:281630002 skin of lower lip + + + + A zone of skin that is part of a lower lip. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a upper lip. + FMA:24765 + SCTID:281629007 + skin of upper lip + + + + + A zone of skin that is part of a upper lip. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A stroma that is part of a pancreas. + FMA:63121 + stroma of pancreas + + + + + A stroma that is part of a pancreas. + OBOL:automatic + @@ -140189,8 +222222,15 @@ + A boundary delimiting a rhombomere. rhombomere boundary + + + + A boundary delimiting a rhombomere. + GO:0021654 + @@ -140210,7 +222250,8 @@ - + EHDAA2:0001842 + EMAPA:35578 skeletal musculature @@ -140237,8 +222278,15 @@ + Any portion of submucosa that lines the digestive tract. submucosa of digestive tract + + + + Any portion of submucosa that lines the digestive tract. + http://orcid.org/0000-0002-6601-2165 + @@ -140263,8 +222311,130 @@ + Any organ component layer that consists of muscle tissue. + FMA:45634 + NCIT:C75444 + UMLS:C0225358 layer of muscle tissue + + + + Any organ component layer that consists of muscle tissue. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A muscular coat that is part of a digestive tract. + muscular coat of digestive tract + + + + + A muscular coat that is part of a digestive tract. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An bone foramen in the ethmoid bone. + Wikipedia:Ethmoidal_foramina + Taxon nodes: In humans, refers to anterior or posterior ethmoid foramina + ethmoid foramen + + + + + An bone foramen in the ethmoid bone. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + The anatomical space within the intestine. + FMA:14586 + TADS:0000495 + WBbt:0005791 + ZFA:0005807 + lumen of intestine + + + + + The anatomical space within the intestine. + http://orcid.org/0000-0002-6601-2165 + @@ -140295,8 +222465,16 @@ + Muscle innervated by the trigeminal nerve (Cranial Nerve V). + MFMO:0000072 trigeminal nerve muscle + + + + Muscle innervated by the trigeminal nerve (Cranial Nerve V). + MFMO:0000072 + @@ -140321,6 +222499,7 @@ + FMA:83450 cardiac muscle tissue of ventricle @@ -140348,8 +222527,86 @@ + An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart. + FMA:73747 + ZFA:0005811 heart vasculature + + + + An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart. + ZFA:0005811 + ZFA:CVS + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + dorsal side of post-anal tail + + + + + + + + + + + + + + + + + + + + + + A membranous sac in animals that serves as the receptacle of a liquid or contains gas. + BTO:0000123 + bladder organ + + + + + A membranous sac in animals that serves as the receptacle of a liquid or contains gas. + BTO:0000123 + @@ -140369,6 +222626,7 @@ + BTO:0002439 reproductive system mucosa @@ -140395,8 +222653,16 @@ + Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes. + BTO:0004043 intramuscular adipose tissue + + + + Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes. + BTO:0004043 + @@ -140421,11 +222687,44 @@ + BTO:0004626 carotid artery endothelium + + + + + + + + + + + + + + + + + + + + + + + + + BTO:0004638 + FMA:13119 + SCTID:88410004 + mucous gland of lung + + + + @@ -140447,8 +222746,16 @@ + Any region of epithelium that is part of a skin region. + BTO:0004382 skin epithelium + + + + Any region of epithelium that is part of a skin region. + http://orcid.org/0000-0002-6601-2165 + @@ -140476,8 +222783,17 @@ + The part of the eye that consists of both the retina and the optic choroid. + SCTID:110701000 chorioretinal region + + + + The part of the eye that consists of both the retina and the optic choroid. + UBERON:drseb + http://orcid.org/0000-0002-6601-2165 + @@ -140502,7 +222818,8 @@ - + DHBA:10654 + FMA:268630 gray matter of hindbrain @@ -140529,7 +222846,8 @@ - + DHBA:10649 + FMA:83913 gray matter of midbrain @@ -140556,6 +222874,8 @@ + EMAPA:35952 + MA:0003174 sensory organ epithelium @@ -140577,8 +222897,16 @@ + An exocrine gland that is part of a integumental system. exocrine gland of integumental system + + + + An exocrine gland that is part of a integumental system. + GOC:dos + http://orcid.org/0000-0002-6601-2165 + @@ -140603,11 +222931,41 @@ + FMA:58315 surface of eyeball + + + + + + + + + + + + + + + + + + + + + + + NCIT:C33596 + SCTID:282511007 + splenic arteriole + + + + @@ -140629,8 +222987,15 @@ + A portion of organism substance that is secreted by a reproductive gland. reproductive gland secretion + + + + A portion of organism substance that is secreted by a reproductive gland. + UBERON:cjm + @@ -140665,8 +223030,16 @@ + Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]. + NLX:149357 nervous system cell part layer + + + + Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]. + NLX:149357 + @@ -140702,8 +223075,16 @@ + Serous membrane layer that is adjacent to and lines an organ. + FMA:15860 visceral serous membrane + + + + Serous membrane layer that is adjacent to and lines an organ. + http://orcid.org/0000-0002-6601-2165 + @@ -140739,8 +223120,17 @@ + Serous membrane layer that lines to a body cavity. + FMA:15859 + MA:0002448 parietal serous membrane + + + + Serous membrane layer that lines to a body cavity. + http://orcid.org/0000-0002-6601-2165 + @@ -140772,8 +223162,17 @@ + A specific region of the foregut into the area in which the lung will develop. + SCTID:34922002 lung field + + + + A specific region of the foregut into the area in which the lung will develop. + GOC:dph + GOC:mtg_lung + @@ -140787,8 +223186,20 @@ + An embryonic or larval epithelium that is committed to form part of the nervous system. + AEO:0001008 + BTO:0000314 + EHDAA2_RETIRED:0004654 + FMA:64807 developing neuroepithelium + + + + An embryonic or larval epithelium that is committed to form part of the nervous system. + AEO:0001008 + AEO:JB + @@ -140796,8 +223207,16 @@ + An epithelium that is undergoing proliferation to provide large numbers of neuronal cells. + AEO:0001009 proliferating neuroepithelium + + + + An epithelium that is undergoing proliferation to provide large numbers of neuronal cells. + AEO:0001009 + @@ -140811,8 +223230,16 @@ + A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells. + AEO:0001010 differentiating neuroepithelium + + + + A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells. + AEO:0001010 + @@ -140838,6 +223265,8 @@ + DHBA:12694 + EMAPA:32916 hindbrain marginal layer @@ -140870,6 +223299,8 @@ + EHDAA2:0001267 + EMAPA:17585 spinal cord ventricular layer @@ -140898,9 +223329,16 @@ - + Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain. cranial neuron projection bundle + + + + Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain. + ISBN:0471888893 + http://orcid.org/0000-0002-6601-2165 + @@ -140926,9 +223364,19 @@ - + The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa. + FMA:5866 + MESH:D017776 + SCTID:276145003 + Wikipedia:Autonomic_nerve autonomic nerve + + + + The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa. + Wikipedia:Autonomic_nerve + @@ -140959,7 +223407,7 @@ - + SCTID:181098007 sympathetic nerve @@ -140969,6 +223417,8 @@ + FMA:79770 + NCIT:C41168 lymphomyeloid tissue @@ -140995,8 +223445,16 @@ + Any substance in the body or expelled from the body that is in a gaseous state. + FMA:84580 bodily gas + + + + Any substance in the body or expelled from the body that is in a gaseous state. + http://orcid.org/0000-0002-6601-2165 + @@ -141025,8 +223483,16 @@ + Any portion of gas located in a part of the respiratory system that is composed primarily of air. + FMA:84581 air in respiratory system + + + + Any portion of gas located in a part of the respiratory system that is composed primarily of air. + http://orcid.org/0000-0002-6601-2165 + @@ -141061,8 +223527,15 @@ + The area of axial mesoderm that develops into the prechordal plate. prechordal mesoderm + + + + The area of axial mesoderm that develops into the prechordal plate. + MGI:anna + @@ -141087,8 +223560,18 @@ + Endocardium that is part of the left atrium. + FMA:7286 + SCTID:190064008 + VHOG:0001226 left atrium endocardium + + + + Endocardium that is part of the left atrium. + http://orcid.org/0000-0002-6601-2165 + @@ -141128,11 +223611,16 @@ - - - + An multicellular anatomical structure that has subparts of multiple organs as a part. + CARO:0020001 multi organ part structure + + + + An multicellular anatomical structure that has subparts of multiple organs as a part. + CARO:0020001 + @@ -141146,11 +223634,17 @@ - - - + A cluster of cells, largely surrounded by a morphological boundary. + CARO:0020002 + FMA:62807 cell cluster + + + + A cluster of cells, largely surrounded by a morphological boundary. + CARO:0020002 + @@ -141177,11 +223671,16 @@ - - - + Material anatomical entity consisting of multiple anatomical structures that are not connected to each other. + CARO:0020000 disconnected anatomical group + + + + Material anatomical entity consisting of multiple anatomical structures that are not connected to each other. + CARO:0020000 + @@ -141195,11 +223694,15 @@ - - - + A collection of anatomical structures that are alike in terms of their morphology or developmental origin. anatomical collection + + + + A collection of anatomical structures that are alike in terms of their morphology or developmental origin. + http://orcid.org/0000-0002-6601-2165 + @@ -141237,8 +223740,51 @@ + A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures. external soft tissue zone + + + + A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts. + BTO:0001513 + epithelium of biliary system + + + + + The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts. + BTO:0001513 + MGI:cs + http://orcid.org/0000-0002-6601-2165 + @@ -141263,8 +223809,15 @@ + Any organ component layer that consists of smooth muscle tissue. layer of smooth muscle tissue + + + + Any organ component layer that consists of smooth muscle tissue. + http://orcid.org/0000-0002-6601-2165 + @@ -141272,11 +223825,75 @@ + FMA:55268 zone of organ + + + + + + + + + + + + + + + + + Any gaseous product of an excretory process. + excreted gas + + + + + Any gaseous product of an excretory process. + http://orcid.org/0000-0002-6601-2165 + + + + + + + + + + + + + + + + + + + + + + + + + + Any excreted gas that is produced by the digestive tract. + FMA:78440 + In mammals, mostly produced as a byproduct of bacterial fermentation in the gastrointestinal (GI) tract, especially the colon, and excreted through the rectum + gas excreted from digestive tract + + + + + Any excreted gas that is produced by the digestive tract. + http://orcid.org/0000-0002-6601-2165 + + + + @@ -141298,8 +223915,15 @@ + Any portion of gas located in a part of the respiratory system. gas in respiratory system + + + + Any portion of gas located in a part of the respiratory system. + http://orcid.org/0000-0002-6601-2165 + @@ -141324,6 +223948,8 @@ + NCIT:C25787 + UMLS:C1512086 epithelial layer of duct @@ -141350,8 +223976,17 @@ + Mesenchyme that is part of a developing jaw [Automatically generated definition]. + EMAPA:32907 + EMAPA:35454 jaw mesenchyme + + + + Mesenchyme that is part of a developing jaw [Automatically generated definition]. + OBOL:automatic + @@ -141376,11 +224011,40 @@ + EMAPA:32904 + MA:0003220 jaw epithelium + + + + + + + + + + + + + + + + + + + + + + SCTID:277967008 + rectal artery + + + + @@ -141411,8 +224075,15 @@ + Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included. material entity in digestive tract + + + + Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included. + https://github.com/EnvironmentOntology/envo/issues/110 + @@ -141437,8 +224108,19 @@ + Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface. + FMA:61695 + NCIT:C29667 + SCTID:261060002 + UMLS:C0489451 entire surface of organism + + + + Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface. + FMA:61695 + @@ -141463,6 +224145,10 @@ + FMA:70505 + NCIT:C32552 + SCTID:244216003 + UMLS:C0447038 branch of external carotid artery @@ -141502,9 +224188,19 @@ - + Any of several arteries that arise from the aorta and supply blood to the esophagus. + FMA:4149 + NCIT:C32535 + SCTID:56548006 + UMLS:C0226294 esophageal artery + + + + Any of several arteries that arise from the aorta and supply blood to the esophagus. + ncithesaurus:Esophageal_Artery + @@ -141529,11 +224225,40 @@ + FMA:51797 + SCTID:149683007 uveal vein + + + + + + + + + + + + + + + + + + + + + + SCTID:77852007 + colic artery + + + + @@ -141561,9 +224286,16 @@ - + The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin. + FMA:225275 vasculature of integument + + + + The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin. + http://orcid.org/0000-0002-6601-2165 + @@ -141588,8 +224320,20 @@ + Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers. + FMA:76719 + NCIT:C33666 + SCTID:341382008 + UMLS:C0226513 + Wikipedia:Superficial_vein superficial vein + + + + Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers. + ncithesaurus:Superficial_Vein + @@ -141614,8 +224358,15 @@ + The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin. deep vasculature + + + + The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin. + http://orcid.org/0000-0002-6601-2165 + @@ -141640,8 +224391,20 @@ + A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery. + FMA:76718 + NCIT:C32444 + SCTID:341484008 + UMLS:C0226514 + Wikipedia:Deep_vein deep vein + + + + A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery. + ncithesaurus:Deep_Vein + @@ -141667,8 +224430,17 @@ + Any chamber of the left side of the heart. + FMA:7166 + SCTID:362008007 left cardiac chamber + + + + Any chamber of the left side of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -141694,8 +224466,17 @@ + Any chamber of the right side of the heart. + FMA:7165 + SCTID:362007002 right cardiac chamber + + + + Any chamber of the right side of the heart. + http://orcid.org/0000-0002-6601-2165 + @@ -141709,8 +224490,23 @@ + The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. + FMA:76554 + NCIT:C32574 + SCTID:120612006 + UMLS:C0229243 + Wikipedia:Accessory_visual_structures ocular adnexa + + + + The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. + HPO:pr + UBERON:cjm + http://medical-dictionary.thefreedictionary.com/ocular+adnexa + https://github.com/obophenotype/uberon/issues/1132 + @@ -141741,6 +224537,8 @@ + EHDAA2:0004181 + FMA:9464 cavity of cardiac chamber @@ -141767,6 +224565,9 @@ + FMA:223208 + NCIT:C12930 + UMLS:C1512970 intrapulmonary bronchus @@ -141794,8 +224595,50 @@ + The primordial mouth region of the developing head. + FMA:293105 future mouth + + + + The primordial mouth region of the developing head. + MP:0003119 + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle layer that is part of the sigmoid colon. + FMA:15028 + muscle layer of sigmoid colon + + + + + A muscle layer that is part of the sigmoid colon. + https://github.com/obophenotype/uberon/issues/1162 + @@ -141820,6 +224663,8 @@ + FMA:12241 + SCTID:304404008 serous cavity @@ -141846,8 +224691,17 @@ + The sum of epicardial and paracardial fat deposits. + SCTID:42267001 + ZFA:0005765 pericardial fat + + + + The sum of epicardial and paracardial fat deposits. + DOI:10.5935/abc.20130138 + @@ -141876,8 +224730,15 @@ + Fat deposits in the mediastinum outside the parietal pericardium . paracardial fat + + + + Fat deposits in the mediastinum outside the parietal pericardium . + DOI:10.5935/abc.20130138 + @@ -141902,8 +224763,15 @@ + Any fat deposit surrounding a visceral organ. visceral fat + + + + Any fat deposit surrounding a visceral organ. + UBERON:cjm + @@ -141938,8 +224806,17 @@ + The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity. + FMA:12267 + Wikipedia:Abdominopelvic_cavity abdominopelvic cavity + + + + The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity. + UBERON:cjm + @@ -141966,8 +224843,17 @@ + A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity. + EMAPA:16137 + FMA:9908 peritoneal sac + + + + A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity. + https://github.com/obophenotype/uberon/issues/86 + @@ -141999,6 +224885,8 @@ + BTO:0004378 + FMA:67473 wall of blood vessel @@ -142035,6 +224923,7 @@ + EHDAA2:0004070 respiratory primordium epithelium @@ -142068,6 +224957,7 @@ + EHDAA2:0004071 respiratory primordium mesenchyme @@ -142080,8 +224970,16 @@ + An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles. cardiopharyngeal field + + + + An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles. + http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1 + https://orcid.org/0000-0003-3308-6245 + @@ -142101,11 +224999,59 @@ + FMA:83520 fibroelastic connective tissue + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical junction that is between the sigmoid colon and rectum. + NCIT:C54188 + SCTID:245429006 + rectosigmoid junction + + + + + An anatomical junction that is between the sigmoid colon and rectum. + NCIT:C54188 + https://github.com/obophenotype/uberon/issues/1319 + https://www.cdc.gov/cancer/npcr/pdf/abstracting/colon.pdf + + + + @@ -142116,11 +225062,17 @@ - - - + Material anatomical entity that forms the outermost boundary of an anatomical structure. + AAO:0010270 + ZFA:0005594 anatomical surface region + + + + Material anatomical entity that forms the outermost boundary of an anatomical structure. + https://github.com/obophenotype/uberon/issues/1324 + @@ -142145,8 +225097,17 @@ + A bodily fluid that is located in the coelom. + BTO:0001708 coelomic fluid + + + + A bodily fluid that is located in the coelom. + PMID:10874572 + https://github.com/obophenotype/uberon/issues/1326 + @@ -142171,8 +225132,15 @@ + Any gland that is part os the respiratory system. respiratory system gland + + + + Any gland that is part os the respiratory system. + UBERON:cjm + @@ -142197,13 +225165,15 @@ - - - - - + A notochord that has persisted beyond the embryonic stage. post-embryonic notochord + + + + A notochord that has persisted beyond the embryonic stage. + UBERON:cjm + @@ -142234,8 +225204,16 @@ + A transudate found in the serous sac. + FMA:20932 secretion of serous membrane + + + + A transudate found in the serous sac. + FMA:20932 + @@ -142260,6 +225238,7 @@ + FMA:53133 orifice of skull @@ -142275,8 +225254,18 @@ + The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit. + FMA:52972 + SCTID:280243001 + Wikipedia:Zygomaticotemporal_nerve zygomaticotemporal nerve + + + + The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit. + Wikipedia:Zygomaticotemporal_nerve + @@ -142301,8 +225290,16 @@ + Wall of ventricle which is continuous with the wall of aorta. + FMA:9556 wall of left ventricle + + + + Wall of ventricle which is continuous with the wall of aorta. + FMA:9556 + @@ -142327,8 +225324,16 @@ + Wall of ventricle which is continuous with the wall of pulmonary trunk. + FMA:9533 wall of right ventricle + + + + Wall of ventricle which is continuous with the wall of pulmonary trunk. + FMA:9533 + @@ -142359,6 +225364,7 @@ + FMA:9560 anterior wall of left ventricle @@ -142385,8 +225391,16 @@ + Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle. + FMA:9553 anterior wall of right ventricle + + + + Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle. + FMA:9553 + @@ -142411,6 +225425,7 @@ + FMA:87177 myocardium of anterior wall of left ventricle @@ -142437,6 +225452,7 @@ + FMA:260877 myocardium of anterior wall of right ventricle @@ -142463,8 +225479,45 @@ + A mucosa that is part of a lip region [Automatically generated definition]. + NCIT:C12226 mucosa of lip + + + + A mucosa that is part of a lip region [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:225251 + SCTID:297287005 + vasculature of spleen + @@ -142506,11 +225559,40 @@ + FMA:259905 vasculature of central nervous system + + + + + + + + + + + + + + + + + + + + + + + FMA:14657 + wall of gallbladder + + + + @@ -142532,6 +225614,7 @@ + FMA:15089 wall of brachiocephalic artery @@ -142558,11 +225641,44 @@ + FMA:15090 wall of subclavian artery + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:15704 + wall of anal canal + + + + @@ -142584,6 +225700,7 @@ + FMA:18211 wall of pulmonary artery @@ -142611,6 +225728,7 @@ + FMA:231590 wall of synovial tendon sheath @@ -142638,11 +225756,41 @@ + FMA:58098 wall of eyeball + + + + + + + + + + + + + + + + + + + + + + + + FMA:63144 + wall of orbit + + + + @@ -142664,6 +225812,7 @@ + FMA:66284 wall of common carotid artery @@ -142703,8 +225852,124 @@ + Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees. + FMA:7274 wall of heart + + + + Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees. + FMA:7274 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An artery that supplies oxygenated blood to the cystic duct. + FMA:14835 + cystic artery + + + + + An artery that supplies oxygenated blood to the cystic duct. + http://orcid.org/0000-0002-6601-2165 + https://en.wikipedia.org/wiki/Cystic_artery + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:15395 + sigmoid vein + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:70471 + pancreatic artery + @@ -142735,8 +226000,16 @@ + Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament. + FMA:14342 right ovarian vein + + + + Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament. + FMA:14342 + @@ -142761,8 +226034,16 @@ + Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament. + FMA:14347 left ovarian vein + + + + Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament. + FMA:14347 + @@ -142787,8 +226068,55 @@ + A zone of skin that is part of the face. + EMAPA:36657 + FMA:24758 + NCIT:C33561 + SCTID:361703006 skin of face + + + + A zone of skin that is part of the face. + UBERON:EJS + https://github.com/obophenotype/uberon/issues/34 + + + + + + + + + + + + + + + + + + + + + + + + + + + A parenchyma that is part of a spleen. + FMA:16029 + parenchyma of spleen + + + + + A parenchyma that is part of a spleen. + OBOL:automatic + @@ -142813,8 +226141,25 @@ + An anatomical junction between two parts of the digestive tract. digestive tract junction + + + + An anatomical junction between two parts of the digestive tract. + https://orcid.org/0000-0002-7073-9172 + + + + + + + + + ZFA:0001073 + axial vasculature + @@ -142839,8 +226184,16 @@ + Cartilage which is part of the axial skeleton. + ZFA:0001457 postcranial axial cartilage + + + + Cartilage which is part of the axial skeleton. + ZFIN:curator + @@ -142849,8 +226202,21 @@ + Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse. + FMA:63196 + NCIT:C32595 + TAO:0005260 + Wikipedia:Capillary#Types + ZFA:0005260 fenestrated capillary + + + + Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse. + Wikipedia:Capillary#Types + Wikipedia:Fenestra_(histology) + @@ -142858,8 +226224,16 @@ + Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes. + ZFA:0007013 preplacodal ectoderm + + + + Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes. + ZFIN:curator + @@ -142884,8 +226258,16 @@ + Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. + Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305 external integument structure + + + + Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. + AAO:EJS + @@ -142910,8 +226292,15 @@ + Dermal, epidermal, glandular and pigment structures of the external head integument. head external integument structure + + + + Dermal, epidermal, glandular and pigment structures of the external head integument. + AAO:EJS + @@ -142936,8 +226325,48 @@ + Dermal, epidermal, glandular and pigment structures of the body integument. body external integument structure + + + + Dermal, epidermal, glandular and pigment structures of the body integument. + AAO:EJS + + + + + + + + + + + + + + + + + + + + + + + + + + Dermal, epidermal, glandular and pigment structures of the tail integument. + tail external integument structure + + + + + Dermal, epidermal, glandular and pigment structures of the tail integument. + AAO:EJS + @@ -142966,8 +226395,15 @@ + Blood vessels in respiratory skin. vasculature of respiratory integument + + + + Blood vessels in respiratory skin. + AAO:EJS + @@ -142992,8 +226428,15 @@ + An anatomical surface that is part of a bone. surface of bone + + + + An anatomical surface that is part of a bone. + PHENOSCAPE + @@ -143045,8 +226488,15 @@ + Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. left side of back + + + + Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. + https://microbiomedb.org/ + @@ -143072,8 +226522,15 @@ + Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. right side of back + + + + Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. + https://microbiomedb.org/ + @@ -143094,8 +226551,556 @@ + A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles. Purkinje fiber network + + + + A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles. + PMID:26786210 + + + + + + + + + + + + + + + + + + + + + + + + + + + Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact. + liver serosa + + + + + Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact. + https://medical-dictionary.thefreedictionary.com/serosa+of+liver + https://orcid.org/0000-0002-0449-2730 + + + + + + + + + + + + + + + + + + + + + + + + + + + Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson. + liver subserosa + + + + + Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson. + FMA:15812 + https://medical-dictionary.thefreedictionary.com/subserosa+of+liver + https://orcid.org/0000-0002-0449-2730 + + + + + + + + + + + + + + + + + + + + + + + + + + Venule of villus of small intestine. + small intestine venule + + + + + Venule of villus of small intestine. + https://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + Arteriole of villus of small intestine. + small intestine arteriole + + + + + Arteriole of villus of small intestine. + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A venule that is located in the anorectum. + venule of anorectum + + + + + A venule that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + An arteriole that is located in the anorectum. + arteriole of anorectum + + + + + An arteriole that is located in the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + An arteriole located in the colon. + arteriole of colon + + + + + An arteriole located in the colon. + http://orcid.org/0000-0003-3440-1876 + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical junction between two parts of the intestine. + intestinal junction + + + + + An anatomical junction between two parts of the intestine. + https://orcid.org/0000-0002-7073-9172 + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosal gland located in a bronchus. + bronchus submucosal gland + + + + + A submucosal gland located in a bronchus. + http://orcid.org/0000-0003-3440-1876 + http://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + A venule located in the colon. + venule of colon + + + + + A venule located in the colon. + https://orcid.org/0000-0003-3440-1876 + https://orcid.org/0000-0003-4183-8865 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus. + anorectum + + + + + A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus. + DOI:10.1007/978-3-319-26938-2_8 + DOI:10.1148/rg.2015150037 + PMID:29742860 + http://orcid.org/0000-0002-6826-8770 + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A capillary that is part of the anorectum. + capillary of anorectum + + + + + A capillary that is part of the anorectum. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A capillary that is part of the colon. + capillary of colon + + + + + A capillary that is part of the colon. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + A capillary that is part of a small intestine. + capillary of small intestine + + + + + A capillary that is part of a small intestine. + http://orcid.org/0000-0003-3440-1876 + + + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosal gland found in a respiratory tract. + EFO:0010666 + airway submucosal gland + + + + + A submucosal gland found in a respiratory tract. + http://orcid.org/0000-0003-3440-1876 + http://orcid.org/0000-0003-4183-8865 + @@ -143104,8 +227109,16 @@ + Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins. blood microvessel + + + + Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins. + Wikipedia:Microcirculation + http://orcid.org/0000-0002-7073-9172 + @@ -143119,8 +227132,15 @@ + Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin). noradrenergic cell groups + + + + Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin). + WikipediaVersioned:Noradrenergic_cell_groups&oldid=965992184 + @@ -143145,9 +227165,15 @@ - + An anatomical system that eliminates waste products that arise as a result of metabolic activity. excretory system + + + + An anatomical system that eliminates waste products that arise as a result of metabolic activity. + GO:0007588 + @@ -143167,8 +227193,15 @@ + A capillary that is part of the brain. capillary of brain + + + + A capillary that is part of the brain. + https://orcid.org/0000-0002-0819-0473 + @@ -143193,8 +227226,15 @@ + A portion of smooth muscle tissue that is part of the thoracic aorta. thoracic aorta smooth muscle tissue + + + + A portion of smooth muscle tissue that is part of the thoracic aorta. + https://orcid.org/0000-0002-0819-0473 + @@ -143219,8 +227259,15 @@ + A zone of skin that is above the clavicle zone in the pectoral girdle region. skin of clavicle region + + + + A zone of skin that is above the clavicle zone in the pectoral girdle region. + https://orcid.org/0000-0002-0819-0473 + @@ -143246,8 +227293,15 @@ + A zone of skin that is part of the external genitalia. skin of external genitalia + + + + A zone of skin that is part of the external genitalia. + https://orcid.org/0000-0002-0819-0473 + @@ -143273,8 +227327,15 @@ + A zone of skin part of some gonad. skin of gonad + + + + A zone of skin part of some gonad. + https://orcid.org/0000-0002-0819-0473 + @@ -143288,8 +227349,25 @@ + A muscle tissue that is associated with soft internal organs (viscera). + It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated. visceral muscle tissue + + + + A muscle tissue that is associated with soft internal organs (viscera). + BTO:0002780 + CLAO:0001295 + + + + + It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated. + FBbt:00005070 + https://en.wikipedia.org/wiki/Smooth_muscle + PMID:8720463 + @@ -143298,8 +227376,52 @@ + A striated muscle tissue that is associated with soft internal organs (viscera). visceral striated muscle tissue + + + + A striated muscle tissue that is associated with soft internal organs (viscera). + PMID:8720463 + https://pressbooks.pub/rbtallitsch/chapter/chapter-6-muscle-tissue/ + + + + + + + + + + + + + + + + + + + + + + + + + + A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium. + submucosal gland acinus + + + + + A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium. + PMID:17394068 + PMID:17707699 + PMID:25648514 + PMID:30864819 + @@ -143320,9 +227442,26 @@ - + A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface. + A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung. bronchopulmonary segment + + + + A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface. + FMA:7312 + PMID:18271171 + PMID:33620799 + doi:10.1016/j.mpaic.2008.09.022 + + + + + A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung. + PMID:18271171 + doi:10.1016/j.mpaic.2008.09.022 + @@ -143361,8 +227500,16 @@ + A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa. pulmonary venule + + + + A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa. + PMID:22283705 + PMID:30247823 + @@ -143404,6 +227551,16 @@ + + + + + + + + + + @@ -143414,6 +227571,37 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -143669,6 +227857,21 @@ + + + + + + + + + + + + + + + @@ -143759,6 +227962,51 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + diff --git a/docs/odk-workflows/RepositoryFileStructure.md b/docs/odk-workflows/RepositoryFileStructure.md index 7ab8590..1c094ea 100644 --- a/docs/odk-workflows/RepositoryFileStructure.md +++ b/docs/odk-workflows/RepositoryFileStructure.md @@ -21,6 +21,7 @@ These are the current imports in CLM | ncbitaxon | http://purl.obolibrary.org/obo/ncbitaxon/subsets/taxslim.owl | None | | go | http://purl.obolibrary.org/obo/go.owl | None | | so | http://purl.obolibrary.org/obo/so.owl | None | +| genes | http://purl.obolibrary.org/obo/genes.owl | None | ## Components Components, in contrast to imports, are considered full members of the ontology. This means that any axiom in a component is also included in the ontology base - which means it is considered _native_ to the ontology. While this sounds complicated, consider this: conceptually, no component should be part of more than one ontology. If that seems to be the case, we are most likely talking about an import. Components are often not needed for ontologies, but there are some use cases: diff --git a/src/markers/NSForestMarkersSource.tsv b/src/markers/NSForestMarkersSource.tsv index ee9f294..a685cb6 100644 --- a/src/markers/NSForestMarkersSource.tsv +++ b/src/markers/NSForestMarkersSource.tsv @@ -1,7 +1,7 @@ -class Cell_type Marker_set Minimal_markers Minimal_markers_label Organ Species Species_abbv Organ_region Parent FBeta_confidence_score Marker_set_xref -CL:4028006 alveolar type 2 fibroblast cell CL:4037001 ncbigene:286133|ncbigene:57124 SCARA5|CD248 Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.85 x -CL:4028004 alveolar type 1 fibroblast cell CL:4037002 ncbigene:8639|ncbigene:4060 AOC3|LUM Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.7 x -CL:0000583 alveolar macrophage CL:4037003 ncbigene:4481|ncbigene:2168 MSR1|FABP4 Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.8 x -CL:4033041 CCL3-positive alveolar macrophage CL:4037004 ncbigene:79931|ncbigene:6374 TNIP3|CXCL5 Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.67 x -CL:4033042 metallothionein-positive alveolar macrophage CL:4037005 ncbigene:3162|ncbigene:3248 HMOX1|HPGD Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.41 x -CL:0000000 cell CL:4037006 ncbigene:9768|ncbigene:6241|ncbigene:11065|ncbigene:51203 PCLAF|RRM2|UBE2C|NUSAP1 Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.26 x \ No newline at end of file +class Cell_type Marker_set Minimal_markers Minimal_markers_label Organ Species Species_abbv Organ_region Parent FBeta_confidence_score Marker_set_xref CL_agreed +CL:4028006 alveolar type 2 fibroblast cell CL:4037001 ensembl:ENSG00000168079|ensembl:ENSG00000174807 SCARA5|CD248 Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.85 https://doi.org/10.5281/zenodo.11165918 True +CL:4028004 alveolar type 1 fibroblast cell CL:4037002 ensembl:ENSG00000131471|ensembl:ENSG00000139329 AOC3|LUM Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.7 https://doi.org/10.5281/zenodo.11165918 True +CL:0000583 alveolar macrophage CL:4037003 ensembl:ENSG00000038945|ensembl:ENSG00000170323 MSR1|FABP4 Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.8 https://doi.org/10.5281/zenodo.11165918 True +CL:4033041 CCL3-positive alveolar macrophage CL:4037004 ensembl:ENSG00000050730|ensembl:ENSG00000163735 TNIP3|CXCL5 Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.67 https://doi.org/10.5281/zenodo.11165918 True +CL:4033042 metallothionein-positive alveolar macrophage CL:4037005 ensembl:ENSG00000100292|ensembl:ENSG00000164120 HMOX1|HPGD Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.41 https://doi.org/10.5281/zenodo.11165918 True +CL:0000000 cell CL:4037006 ensembl:ENSG00000166803|ensembl:ENSG00000171848|ensembl:ENSG00000175063|ensembl:ENSG00000137804 PCLAF|RRM2|UBE2C|NUSAP1 Lung NCBITaxon:9606 Human UBERON:0002048 SO:0001260 0.26 https://doi.org/10.5281/zenodo.11165918 \ No newline at end of file diff --git a/src/ontology/Makefile b/src/ontology/Makefile index 1e6e961..777d17a 100644 --- a/src/ontology/Makefile +++ b/src/ontology/Makefile @@ -10,7 +10,7 @@ # More information: https://github.com/INCATools/ontology-development-kit/ # Fingerprint of the configuration file when this Makefile was last generated -CONFIG_HASH= 1075a01896dd9209d91e074ab93b98c01de3e912d0178ad0e8ce9fe89cb1c2bf +CONFIG_HASH= da84ed40be50b0eaa48e4a56d548e2317e4cb084c693fd39a508716dc330c2dc # ---------------------------------------- @@ -164,7 +164,7 @@ all_main: $(MAIN_FILES) # ---------------------------------------- -IMPORTS = cl uberon ncbitaxon go so +IMPORTS = cl uberon ncbitaxon go so genes IMPORT_ROOTS = $(IMPORTDIR)/merged_import IMPORT_OWL_FILES = $(foreach n,$(IMPORT_ROOTS), $(n).owl) @@ -495,6 +495,14 @@ mirror-so: | $(TMPDIR) curl -L $(OBOBASE)/so.owl --create-dirs -o $(TMPDIR)/so-download.owl --retry 4 --max-time 400 && \ $(ROBOT) remove -i $(TMPDIR)/so-download.owl --base-iri $(OBOBASE)/SO --axioms external --preserve-structure false --trim false -o $(TMPDIR)/$@.owl + +## ONTOLOGY: genes +.PHONY: mirror-genes +.PRECIOUS: $(MIRRORDIR)/genes.owl +mirror-genes: | $(TMPDIR) + curl -L $(OBOBASE)/genes.owl --create-dirs -o $(TMPDIR)/genes-download.owl --retry 4 --max-time 400 && \ + $(ROBOT) remove -i $(TMPDIR)/genes-download.owl --base-iri $(OBOBASE)/GENES --axioms external --preserve-structure false --trim false -o $(TMPDIR)/$@.owl + ALL_MIRRORS = $(patsubst %, $(MIRRORDIR)/%.owl, $(IMPORTS)) MERGE_MIRRORS = true diff --git a/src/ontology/clm-edit.owl b/src/ontology/clm-edit.owl index d74aefe..d025e97 100644 --- a/src/ontology/clm-edit.owl +++ b/src/ontology/clm-edit.owl @@ -12,9 +12,8 @@ Prefix(dcterms:=) Ontology( Import() - - Import() + Annotation(dcterms:description "None") Annotation(dcterms:license ) Annotation(dcterms:title "Cell Markers Ontology") @@ -24,6 +23,7 @@ Declaration(Class()) Declaration(AnnotationProperty(dcterms:description)) Declaration(AnnotationProperty(dcterms:license)) Declaration(AnnotationProperty(dcterms:title)) +Declaration(ObjectProperty()) ############################ # Annotation Properties @@ -33,6 +33,9 @@ AnnotationAssertion(rdfs:label dcterms:description "description") AnnotationAssertion(rdfs:label dcterms:license "license") AnnotationAssertion(rdfs:label dcterms:title "title") +# Object Property: (has characterizing marker set) +AnnotationAssertion(rdfs:label "has characterizing marker set") + ############################ # Classes ############################ diff --git a/src/ontology/clm.Makefile b/src/ontology/clm.Makefile index e3c3478..31c2c6a 100644 --- a/src/ontology/clm.Makefile +++ b/src/ontology/clm.Makefile @@ -14,9 +14,8 @@ SOURCE_TABLE = $(MARKERSDIR)/NSForestMarkersSource.tsv GENE_LIST = LungMAP LungCellAtlas GENE_TABLES = $(patsubst %, $(TEMPLATESDIR)/%.tsv, $(GENE_LIST)) GENE_TEMPLATE = $(TEMPLATESDIR)/genes.tsv -GENE_IMPORT_MODULE = $(MIRRORDIR)/genes.owl -LOCAL_CLEAN_FILES = $(GENE_IMPORT_MODULE) $(GENE_TEMPLATE) +LOCAL_CLEAN_FILES = $(GENE_TEMPLATE) # clean previous build files .PHONY: clean_files @@ -26,11 +25,12 @@ clean_files: $(GENE_TEMPLATE): $(GENE_TABLES) python $(SCRIPTSDIR)/robot_template_generator.py genes $(patsubst %, -i %, $^) --out $@ -$(GENE_IMPORT_MODULE): $(GENE_TEMPLATE) +$(MIRRORDIR)/genes.owl: $(GENE_TEMPLATE) $(ROBOT) template --input $(SRC) --template $< --add-prefixes template_prefixes.json --output $@ -$(COMPONENTSDIR)/all_templates.owl: clean_files $(SRC) $(GENE_IMPORT_MODULE) - $(ROBOT) merge --input $(SRC) --input $(GENE_IMPORT_MODULE) --output $@ +$(COMPONENTSDIR)/all_templates.owl: clean_files + #$(ROBOT) merge --input $(SRC) --input $(GENE_IMPORT_MODULE) --output $@ + echo "Templates ready" .PRECIOUS: $(COMPONENTSDIR)/all_templates.owl diff --git a/src/ontology/imports/genes_terms.txt b/src/ontology/imports/genes_terms.txt new file mode 100644 index 0000000..8b13789 --- /dev/null +++ b/src/ontology/imports/genes_terms.txt @@ -0,0 +1 @@ + diff --git a/src/ontology/imports/merged_import.owl b/src/ontology/imports/merged_import.owl index f4e509c..e801f75 100644 --- a/src/ontology/imports/merged_import.owl +++ b/src/ontology/imports/merged_import.owl @@ -7,9 +7,23 @@ Prefix(rdfs:=) Ontology( - -Annotation(owl:versionInfo "2024-07-26") - + +Annotation(owl:versionInfo "2024-07-29") + +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -19,19 +33,27 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -41,15 +63,24 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -94,6 +125,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -126,9 +158,14 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -157,6 +194,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -170,6 +208,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -178,7 +217,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -187,6 +228,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -216,7 +262,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -296,6 +344,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -304,8 +353,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -318,6 +370,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -325,11 +378,18 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -338,6 +398,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -351,7 +412,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -361,7 +424,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -378,13 +445,16 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -397,14 +467,32 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -425,6 +513,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -434,11 +523,20 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -451,11 +549,13 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -464,13 +564,23 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -489,14 +599,19 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -510,12 +625,17 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -524,6 +644,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -550,11 +671,13 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -598,6 +721,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -632,6 +756,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -657,6 +782,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -770,6 +896,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -817,6 +944,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -841,9 +971,17 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -867,6 +1005,15 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -906,11 +1053,27 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -920,15 +1083,20 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -971,6 +1139,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1014,7 +1183,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1026,10 +1197,14 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1037,10 +1212,13 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1050,13 +1228,19 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1070,12 +1254,15 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1088,6 +1275,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1124,6 +1314,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1163,6 +1356,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1186,11 +1381,18 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1198,6 +1400,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1240,6 +1443,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1261,22 +1467,38 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1287,19 +1509,29 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1383,6 +1615,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1401,6 +1636,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1409,12 +1645,14 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1437,8 +1675,12 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1466,6 +1708,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1499,6 +1744,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1523,10 +1771,18 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1545,6 +1801,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1555,6 +1812,12 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1565,8 +1828,12 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1574,7 +1841,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1612,11 +1883,15 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1633,6 +1908,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1648,6 +1926,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1680,13 +1959,19 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1715,8 +2000,10 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1751,20 +2038,31 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1772,7 +2070,10 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1780,6 +2081,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1804,9 +2106,14 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1830,6 +2137,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1847,12 +2157,15 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1860,11 +2173,19 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1947,8 +2268,13 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1963,6 +2289,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1991,6 +2319,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2002,6 +2332,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2023,6 +2355,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2038,6 +2371,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2089,9 +2424,12 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2178,6 +2516,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2211,14 +2550,19 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2227,9 +2571,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2248,8 +2594,13 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2305,7 +2656,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2384,13 +2739,16 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2433,6 +2791,10 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2463,6 +2825,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2507,6 +2871,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2561,6 +2928,12 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2595,16 +2968,22 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2625,16 +3004,21 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2649,7 +3033,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2661,6 +3047,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2670,6 +3059,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2692,11 +3082,19 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2709,6 +3107,12 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2716,6 +3120,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2760,16 +3166,22 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2834,6 +3246,10 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2845,6 +3261,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2852,6 +3269,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2888,11 +3310,13 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2955,6 +3379,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2962,6 +3387,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2989,6 +3417,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3006,8 +3437,13 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3020,6 +3456,10 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3031,13 +3471,22 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3059,9 +3508,13 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3082,8 +3535,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3114,16 +3570,21 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3170,10 +3631,18 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3243,10 +3712,13 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3268,6 +3740,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3280,6 +3755,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3292,6 +3768,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3307,6 +3786,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3321,14 +3803,32 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3343,6 +3843,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3353,10 +3854,17 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3395,6 +3903,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3405,12 +3914,16 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3425,6 +3938,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3535,10 +4051,16 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3546,6 +4068,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3572,6 +4097,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3585,6 +4113,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3629,6 +4160,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3651,6 +4185,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3689,6 +4224,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3699,12 +4235,16 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3727,6 +4267,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3766,12 +4307,20 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3781,13 +4330,16 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3798,6 +4350,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3870,18 +4423,27 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3896,6 +4458,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3939,19 +4502,31 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3963,9 +4538,12 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3973,6 +4551,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3988,6 +4567,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3996,6 +4576,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4020,6 +4601,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4032,13 +4614,18 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4047,23 +4634,76 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4092,18 +4732,26 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4130,6 +4778,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4137,6 +4786,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4149,22 +4799,27 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4190,13 +4845,19 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4227,6 +4888,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4243,6 +4906,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4261,6 +4925,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4270,29 +4936,39 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4322,12 +4998,14 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4341,12 +5019,20 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4354,12 +5040,25 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4374,6 +5073,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4383,16 +5087,20 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4410,8 +5118,10 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4430,6 +5140,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4445,10 +5156,15 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4478,12 +5194,17 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4497,17 +5218,25 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4526,13 +5255,19 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4559,11 +5294,13 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4576,8 +5313,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4587,7 +5327,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4612,6 +5354,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4621,29 +5364,42 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4655,14 +5411,42 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4671,6 +5455,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4683,6 +5469,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4690,6 +5477,10 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4721,6 +5512,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4734,10 +5527,15 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4745,9 +5543,12 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4761,16 +5562,20 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4779,21 +5584,34 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4807,24 +5625,34 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4851,6 +5679,12 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4858,6 +5692,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4881,6 +5716,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4891,6 +5729,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4901,6 +5741,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4910,7 +5751,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4919,21 +5762,30 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4944,6 +5796,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4955,11 +5808,27 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4976,20 +5845,28 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5001,14 +5878,17 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5016,19 +5896,26 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5044,8 +5931,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5058,8 +5948,12 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5067,6 +5961,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5074,21 +5970,32 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5097,13 +6004,17 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5120,12 +6031,17 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5139,28 +6055,61 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5175,6 +6124,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5184,17 +6134,24 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5205,41 +6162,69 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5247,6 +6232,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5271,18 +6257,23 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5293,6 +6284,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5304,6 +6296,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5318,31 +6311,56 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5353,6 +6371,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(ObjectProperty()) @@ -5376,6 +6395,9 @@ Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) +Declaration(ObjectProperty()) +Declaration(ObjectProperty()) +Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) @@ -5416,6 +6438,7 @@ Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) +Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) @@ -5432,6 +6455,7 @@ Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) +Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) @@ -5441,6 +6465,7 @@ Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) +Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) @@ -5459,6 +6484,7 @@ Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) +Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) @@ -5475,6 +6501,7 @@ Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) +Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) @@ -5482,6 +6509,8 @@ Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) +Declaration(ObjectProperty()) +Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) Declaration(ObjectProperty()) @@ -5492,12 +6521,21 @@ Declaration(ObjectProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) -Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) +Declaration(AnnotationProperty()) +Declaration(AnnotationProperty(rdfs:comment)) +############################ +# Annotation Properties +############################ + +# Annotation Property: (database_cross_reference) + +AnnotationAssertion(rdfs:label "database_cross_reference") + ############################ # Object Properties @@ -5505,25 +6543,30 @@ Declaration(AnnotationProperty()) # Object Property: (part of) +AnnotationAssertion( "BFO:0000050") AnnotationAssertion(rdfs:label "part of") InverseObjectProperties( ) TransitiveObjectProperty() # Object Property: (has part) +AnnotationAssertion( "BFO:0000051") AnnotationAssertion(rdfs:label "has part") TransitiveObjectProperty() # Object Property: (preceded by) +AnnotationAssertion( "BFO:0000062") AnnotationAssertion(rdfs:label "preceded by") # Object Property: (precedes) +AnnotationAssertion( "BFO:0000063") AnnotationAssertion(rdfs:label "precedes") # Object Property: (occurs in) +AnnotationAssertion( "BFO:0000066") AnnotationAssertion(rdfs:label "occurs in") # Object Property: (lacks_part) @@ -5536,191 +6579,241 @@ AnnotationAssertion(rdfs:label "lack # Object Property: (results in distribution of) +AnnotationAssertion( "GOREL:0002003") AnnotationAssertion(rdfs:label "results in distribution of") AnnotationAssertion(rdfs:label "results_in_distribution_of") # Object Property: (results in fission of) +AnnotationAssertion( "GOREL:0002004") AnnotationAssertion(rdfs:label "results in fission of") AnnotationAssertion(rdfs:label "results_in_fission_of") SubObjectPropertyOf( ) # Object Property: (bearer of) +AnnotationAssertion( "RO:0000053") AnnotationAssertion(rdfs:label "bearer of") # Object Property: (participates in) +AnnotationAssertion( "RO:0000056") AnnotationAssertion(rdfs:label "participates in") # Object Property: (has participant) +AnnotationAssertion( "RO:0000057") AnnotationAssertion(rdfs:label "has participant") # Object Property: (bounding layer of) +AnnotationAssertion( "RO:0002007") AnnotationAssertion(rdfs:label "bounding layer of") # Object Property: (immediately preceded by) +AnnotationAssertion( "RO:0002087") AnnotationAssertion(rdfs:label "immediately preceded by") # Object Property: (overlaps) +AnnotationAssertion( "RO:0002131") AnnotationAssertion(rdfs:label "overlaps") # Object Property: (has component) +AnnotationAssertion( "RO:0002180") AnnotationAssertion(rdfs:label "has component") # Object Property: (regulates) +AnnotationAssertion( "RO:0002211") AnnotationAssertion(rdfs:label "regulates") TransitiveObjectProperty() # Object Property: (negatively regulates) +AnnotationAssertion( "RO:0002212") AnnotationAssertion(rdfs:label "negatively regulates") SubObjectPropertyOf( ) # Object Property: (positively regulates) +AnnotationAssertion( "RO:0002213") AnnotationAssertion(rdfs:label "positively regulates") SubObjectPropertyOf( ) # Object Property: (capable of) +AnnotationAssertion( "RO:0002215") AnnotationAssertion(rdfs:label "capable of") # Object Property: (capable of part of) +AnnotationAssertion( "RO:0002216") AnnotationAssertion(rdfs:label "capable of part of") # Object Property: (adjacent to) +AnnotationAssertion( "RO:0002220") AnnotationAssertion(rdfs:label "adjacent to") # Object Property: (starts with) +AnnotationAssertion( "RO:0002224") AnnotationAssertion(rdfs:label "starts with") # Object Property: (ends with) +AnnotationAssertion( "RO:0002230") AnnotationAssertion(rdfs:label "ends with") # Object Property: (has start location) +AnnotationAssertion( "RO:0002231") AnnotationAssertion(rdfs:label "has start location") # Object Property: (has end location) +AnnotationAssertion( "RO:0002232") AnnotationAssertion(rdfs:label "has end location") # Object Property: (results in developmental progression of) +AnnotationAssertion( "RO:0002295") AnnotationAssertion(rdfs:label "results in developmental progression of") # Object Property: (results in development of) +AnnotationAssertion( "RO:0002296") AnnotationAssertion(rdfs:label "results in development of") # Object Property: (results in formation of) +AnnotationAssertion( "RO:0002297") AnnotationAssertion(rdfs:label "results in formation of") # Object Property: (results in morphogenesis of) +AnnotationAssertion( "RO:0002298") AnnotationAssertion(rdfs:label "results in morphogenesis of") # Object Property: (results in maturation of) +AnnotationAssertion( "RO:0002299") AnnotationAssertion(rdfs:label "results in maturation of") # Object Property: (results in acquisition of features of) +AnnotationAssertion( "RO:0002315") AnnotationAssertion(rdfs:label "results in acquisition of features of") +# Object Property: (regulates levels of) + +AnnotationAssertion( "RO:0002332") +AnnotationAssertion(rdfs:label "regulates levels of") + # Object Property: (has target start location) +AnnotationAssertion( "RO:0002338") AnnotationAssertion(rdfs:label "has target start location") # Object Property: (has target end location) +AnnotationAssertion( "RO:0002339") AnnotationAssertion(rdfs:label "has target end location") # Object Property: (results in transport along) +AnnotationAssertion( "RO:0002341") AnnotationAssertion(rdfs:label "results in transport along") # Object Property: (results in transport across) +AnnotationAssertion( "RO:0002342") AnnotationAssertion(rdfs:label "results in transport across") # Object Property: (results in growth of) +AnnotationAssertion( "RO:0002343") AnnotationAssertion(rdfs:label "results in growth of") # Object Property: (results in transport to from or in) +AnnotationAssertion( "RO:0002344") AnnotationAssertion(rdfs:label "results in transport to from or in") # Object Property: (output of) +AnnotationAssertion( "RO:0002353") AnnotationAssertion(rdfs:label "output of") # Object Property: (results in movement of) +AnnotationAssertion( "RO:0002565") AnnotationAssertion(rdfs:label "results in movement of") # Object Property: (results in assembly of) +AnnotationAssertion( "RO:0002588") AnnotationAssertion(rdfs:label "results in assembly of") # Object Property: (results in disassembly of) +AnnotationAssertion( "RO:0002590") AnnotationAssertion(rdfs:label "results in disassembly of") # Object Property: (results in organization of) +AnnotationAssertion( "RO:0002592") AnnotationAssertion(rdfs:label "results in organization of") SubObjectPropertyOf( ) # Object Property: (process has causal agent) +AnnotationAssertion( "RO:0002608") AnnotationAssertion(rdfs:label "process has causal agent") # Object Property: (produces) +AnnotationAssertion( "RO:0003000") AnnotationAssertion(rdfs:label "produces") # Object Property: (produced by) +AnnotationAssertion( "RO:0003001") AnnotationAssertion(rdfs:label "produced by") # Object Property: (has primary input or output) +AnnotationAssertion( "RO:0004007") AnnotationAssertion(rdfs:label "has primary input or output") # Object Property: (has primary output) +AnnotationAssertion( "RO:0004008") AnnotationAssertion(rdfs:label "has primary output") # Object Property: (has primary input) +AnnotationAssertion( "RO:0004009") AnnotationAssertion(rdfs:label "has primary input") # Object Property: (acts on population of) +AnnotationAssertion( "RO:0012003") AnnotationAssertion(rdfs:label "acts on population of") SubObjectPropertyOf( ) # Object Property: (results in fusion of) +AnnotationAssertion( "RO:0012008") AnnotationAssertion(rdfs:label "results in fusion of") SubObjectPropertyOf( ) # Object Property: (anteriorly connected to) +AnnotationAssertion(Annotation( "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern") "x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y.") AnnotationAssertion(rdfs:label "anteriorly connected to") SubObjectPropertyOf( ) SubObjectPropertyOf( ) @@ -5744,6 +6837,7 @@ TransitiveObjectProperty( (distally connected to) +AnnotationAssertion(Annotation( "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern") "x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y.") AnnotationAssertion(rdfs:label "distally connected to") SubObjectPropertyOf( ) SubObjectPropertyOf( ) @@ -5752,6 +6846,7 @@ InverseObjectProperties( (extends_fibers_into) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-7073-9172") "X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y") AnnotationAssertion(rdfs:label "extends_fibers_into") SubObjectPropertyOf( ) SymmetricObjectProperty() @@ -5759,10 +6854,23 @@ SymmetricObjectProperty( (filtered through) AnnotationAssertion( "Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity.") +AnnotationAssertion(rdfs:comment "Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed") AnnotationAssertion(rdfs:label "filtered through") +# Object Property: (indirectly_supplies) + +AnnotationAssertion( "a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s.") +AnnotationAssertion(rdfs:label "indirectly_supplies") +TransitiveObjectProperty() + +# Object Property: (layer part of) + +AnnotationAssertion(rdfs:label "layer part of") +SubObjectPropertyOf( ) + # Object Property: (posteriorly connected to) +AnnotationAssertion(Annotation( "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern") "x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y.") AnnotationAssertion(rdfs:label "posteriorly connected to") SubObjectPropertyOf( ) SubObjectPropertyOf( ) @@ -5773,6 +6881,7 @@ AnnotationAssertion(rdfs:label (proximally connected to) +AnnotationAssertion(Annotation( "http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern") "x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y.") AnnotationAssertion(rdfs:label "proximally connected to") SubObjectPropertyOf( ) SubObjectPropertyOf( ) @@ -5785,6 +6894,7 @@ AnnotationAssertion(rdfs:label (subdivision of) +AnnotationAssertion(rdfs:comment "placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B") AnnotationAssertion(rdfs:label "subdivision of") # Object Property: (transitively anteriorly connected to) @@ -5808,6 +6918,76 @@ TransitiveObjectProperty( (MSR1) + +AnnotationAssertion(rdfs:label "MSR1") +SubClassOf( ) + +# Class: (TNIP3) + +AnnotationAssertion(rdfs:label "TNIP3") +SubClassOf( ) + +# Class: (HMOX1) + +AnnotationAssertion(rdfs:label "HMOX1") +SubClassOf( ) + +# Class: (AOC3) + +AnnotationAssertion(rdfs:label "AOC3") +SubClassOf( ) + +# Class: (NUSAP1) + +AnnotationAssertion(rdfs:label "NUSAP1") +SubClassOf( ) + +# Class: (LUM) + +AnnotationAssertion(rdfs:label "LUM") +SubClassOf( ) + +# Class: (CXCL5) + +AnnotationAssertion(rdfs:label "CXCL5") +SubClassOf( ) + +# Class: (HPGD) + +AnnotationAssertion(rdfs:label "HPGD") +SubClassOf( ) + +# Class: (PCLAF) + +AnnotationAssertion(rdfs:label "PCLAF") +SubClassOf( ) + +# Class: (SCARA5) + +AnnotationAssertion(rdfs:label "SCARA5") +SubClassOf( ) + +# Class: (FABP4) + +AnnotationAssertion(rdfs:label "FABP4") +SubClassOf( ) + +# Class: (RRM2) + +AnnotationAssertion(rdfs:label "RRM2") +SubClassOf( ) + +# Class: (CD248) + +AnnotationAssertion(rdfs:label "CD248") +SubClassOf( ) + +# Class: (UBE2C) + +AnnotationAssertion(rdfs:label "UBE2C") +SubClassOf( ) + # Class: () SubClassOf( ) @@ -5818,6 +6998,16 @@ EquivalentClasses( (cell) +AnnotationAssertion(Annotation( "CARO:mah") "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.") +AnnotationAssertion( "CALOHA:TS-2035") +AnnotationAssertion( "FMA:68646") +AnnotationAssertion( "GO:0005623") +AnnotationAssertion( "KUPO:0000002") +AnnotationAssertion( "MESH:D002477") +AnnotationAssertion( "VHOG:0001533") +AnnotationAssertion( "WBbt:0004017") +AnnotationAssertion( "XAO:0003012") +AnnotationAssertion(rdfs:comment "The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).") AnnotationAssertion(rdfs:label "cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -5827,6 +7017,7 @@ DisjointClasses( (neural crest derived fibroblast) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0001-5208-3432") "Any fibroblast that is derived from the neural crest.") AnnotationAssertion(rdfs:label "neural crest derived fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5834,6 +7025,7 @@ SubClassOf( ObjectSomeValuesFrom( (neuronal receptor cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception.") AnnotationAssertion(rdfs:label "neuronal receptor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5841,21 +7033,25 @@ SubClassOf( (early embryonic cell (metazoa)) +AnnotationAssertion(Annotation( "GOC:tfm") "A cell found in the embryo before the formation of all the gem layers is complete.") AnnotationAssertion(rdfs:label "early embryonic cell (metazoa)") SubClassOf( ) # Class: (migratory cranial neural crest cell) +AnnotationAssertion(Annotation( "ZFA:0007091") Annotation( "https://orcid.org/0000-0001-5208-3432") "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination.") AnnotationAssertion(rdfs:label "migratory cranial neural crest cell") SubClassOf( ) # Class: (migratory trunk neural crest cell) +AnnotationAssertion(Annotation( "ZFA:0007095") Annotation( "https://orcid.org/0000-0001-5208-3432") "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination.") AnnotationAssertion(rdfs:label "migratory trunk neural crest cell") SubClassOf( ) # Class: (germ line stem cell) +AnnotationAssertion(Annotation( "doi:10.1016/j.stem.2012.05.016") "A stem cell that is the precursor of gametes.") AnnotationAssertion(rdfs:label "germ line stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5863,6 +7059,10 @@ SubClassOf( (female germ cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:11023867") Annotation( "PMID:20454446") "Female germ cell is a germ cell that supports female gamete production.") +AnnotationAssertion( "MA:0000388") +AnnotationAssertion( "VHOG:0001530") +AnnotationAssertion( "ncithesaurus:Egg") AnnotationAssertion(rdfs:label "female germ cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5870,6 +7070,7 @@ SubClassOf( ObjectSomeValuesFrom( (female germ line stem cell) +AnnotationAssertion(Annotation( "doi:10.1016/j.stem.2012.05.016") "A stem cell that is the precursor of female gametes.") AnnotationAssertion(rdfs:label "female germ line stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5877,6 +7078,12 @@ SubClassOf( (oocyte) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "A female germ cell that has entered meiosis.") +AnnotationAssertion( "BTO:0000964") +AnnotationAssertion( "CALOHA:TS-0711") +AnnotationAssertion( "FMA:18644") +AnnotationAssertion( "MESH:D009865") +AnnotationAssertion( "WBbt:0006797") AnnotationAssertion(rdfs:label "oocyte") SubClassOf( ) SubClassOf( ) @@ -5886,6 +7093,8 @@ SubClassOf( ObjectSomeValuesFrom( (oogonial cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes.") +AnnotationAssertion( "FMA:83673") AnnotationAssertion(rdfs:label "oogonial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5895,6 +7104,12 @@ SubClassOf( ObjectSomeValuesFrom( (egg cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization.") +AnnotationAssertion( "BTO:0000369") +AnnotationAssertion( "BTO:0003801") +AnnotationAssertion( "CALOHA:TS-2191") +AnnotationAssertion( "FMA:67343") +AnnotationAssertion( "MESH:D010063") AnnotationAssertion(rdfs:label "egg cell") SubClassOf( ) SubClassOf( ) @@ -5903,6 +7118,7 @@ SubClassOf( ObjectSomeValuesFrom( (smooth muscle cell neural crest derived) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0001-5208-3432") "A smooth muscle cell derived from the neural crest.") AnnotationAssertion(rdfs:label "smooth muscle cell neural crest derived") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5910,6 +7126,7 @@ SubClassOf( ObjectSomeValuesFrom( (neural crest derived neuron) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any neuron that develops from some migratory neural crest cell.") AnnotationAssertion(rdfs:label "neural crest derived neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5918,6 +7135,9 @@ SubClassOf( ObjectSomeValuesFrom( (neuroblast (sensu Vertebrata)) +AnnotationAssertion(Annotation( "GOC:NV") Annotation( "http://en.wikipedia.org/wiki/Neuroblast") "A cell that will develop into a neuron often after a migration phase.") +AnnotationAssertion( "BTO:0000930") +AnnotationAssertion( "FMA:70563") AnnotationAssertion(rdfs:label "neuroblast (sensu Vertebrata)") SubClassOf( ) SubClassOf( ) @@ -5925,7 +7145,10 @@ SubClassOf( ObjectSomeValuesFrom( (stem cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "MESH:D013234") "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.") +AnnotationAssertion( "CALOHA:TS-2086") +AnnotationAssertion( "FMA:63368") +AnnotationAssertion(rdfs:comment "This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’.") AnnotationAssertion(rdfs:label "stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5934,6 +7157,8 @@ SubClassOf( ObjectSomeValuesFrom( (single fate stem cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A stem cell that self-renews as well as give rise to a single mature cell type.") +AnnotationAssertion( "FMA:70569") AnnotationAssertion(rdfs:label "single fate stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5941,7 +7166,13 @@ SubClassOf( ObjectSomeValuesFrom( (hematopoietic stem cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:dsd") Annotation( "GOC:tfm") Annotation( "PMID:19022770") Annotation( "http://en.wikipedia.org/wiki/Hematopoietic_stem_cell") "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.") +AnnotationAssertion( "BTO:0000725") +AnnotationAssertion( "CALOHA:TS-0448") +AnnotationAssertion( "FMA:86475") +AnnotationAssertion( "MESH:D006412") +AnnotationAssertion( "VHOG:0001485") +AnnotationAssertion(rdfs:comment "Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.") AnnotationAssertion(rdfs:label "hematopoietic stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5964,6 +7195,8 @@ SubClassOf( ObjectSomeValuesFrom( (erythroid progenitor cell) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0721601464") "A progenitor cell committed to the erythroid lineage.") +AnnotationAssertion( "BTO:0004911") AnnotationAssertion(rdfs:label "erythroid progenitor cell") SubClassOf( ) SubClassOf( ) @@ -5971,12 +7204,18 @@ SubClassOf( ObjectSomeValuesFrom( (germ line cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring.") +AnnotationAssertion(rdfs:comment "Originally this term had some plant germ line cell children.") AnnotationAssertion(rdfs:label "germ line cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (monoblast) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:1104740") Annotation( "http://en.wikipedia.org/wiki/Monoblast") Annotation( "http://www.copewithcytokines.de") "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus.") +AnnotationAssertion( "CALOHA:TS-1195") +AnnotationAssertion( "FMA:83553") +AnnotationAssertion(rdfs:comment "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.") AnnotationAssertion(rdfs:label "monoblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5989,6 +7228,8 @@ SubClassOf( ObjectSomeValuesFrom( (multi fate stem cell) +AnnotationAssertion(Annotation( "GOC:add") "A stem cell that can give rise to multiple lineages of cells.") +AnnotationAssertion( "FMA:84789") AnnotationAssertion(rdfs:label "multi fate stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -5996,7 +7237,9 @@ SubClassOf( ObjectSomeValuesFrom( (common myeloid progenitor) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0878932437") Annotation( "MESH:D023461") "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.") +AnnotationAssertion( "BTO:0004730") +AnnotationAssertion(rdfs:comment "This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).") AnnotationAssertion(rdfs:label "common myeloid progenitor") SubClassOf( ) DisjointClasses( ) @@ -6005,7 +7248,8 @@ DisjointClasses( (megakaryocyte-erythroid progenitor cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:dsd") Annotation( "GOC:tfm") Annotation( "MESH:D055015") Annotation( "PMID:16647566") Annotation( "http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell") "A progenitor cell committed to the megakaryocyte and erythroid lineages.") +AnnotationAssertion(rdfs:comment "MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2.") AnnotationAssertion(rdfs:label "megakaryocyte-erythroid progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6018,7 +7262,8 @@ DisjointClasses( (common lymphoid progenitor) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:dsd") Annotation( "GOC:tfm") Annotation( "PMID:10407577") Annotation( "PMID:16551251") "A oligopotent progenitor cell committed to the lymphoid lineage.") +AnnotationAssertion(rdfs:comment "CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.") AnnotationAssertion(rdfs:label "common lymphoid progenitor") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6027,22 +7272,40 @@ SubClassOf( ObjectSomeValuesFrom( (totipotent stem cell) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") "A stem cell from which all cells of the body can form.") +AnnotationAssertion( "FMA:84790") +AnnotationAssertion( "MESH:D039901") AnnotationAssertion(rdfs:label "totipotent stem cell") SubClassOf( ) # Class: (non-terminally differentiated cell) +AnnotationAssertion(Annotation( "SANBI:mhl") "A precursor cell with a limited number of potential fates.") +AnnotationAssertion( "BTO:0000125") +AnnotationAssertion( "FMA:84782") +AnnotationAssertion(rdfs:comment "define using PATO mulit-potent or oligopotent?") AnnotationAssertion(rdfs:label "non-terminally differentiated cell") SubClassOf( ) # Class: (myoblast) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "MESH:D032446") Annotation( "PMID:21849021") "A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair.") +AnnotationAssertion( "BTO:0000222") +AnnotationAssertion( "CALOHA:TS-0650") +AnnotationAssertion( "FMA:70335") +AnnotationAssertion( "VHOG:0001529") AnnotationAssertion(rdfs:label "myoblast") SubClassOf( ) # Class: (fibroblast) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0517223651") Annotation( "MESH:D005347") Annotation( "http://en.wikipedia.org/wiki/Fibroblast") "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.") +AnnotationAssertion( "BTO:0000452") +AnnotationAssertion( "CALOHA:TS-0362") +AnnotationAssertion( "FMA:63877") +AnnotationAssertion( "NCIT:C12482") +AnnotationAssertion( "VHOG:0001482") +AnnotationAssertion(rdfs:comment "These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.") AnnotationAssertion(rdfs:label "fibroblast") SubClassOf( ) SubClassOf( ) @@ -6050,6 +7313,9 @@ SubClassOf( ObjectSomeValuesFrom( (chondroblast) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "GO_REF:0000034") Annotation( "ISBN:0618947256") "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell.") +AnnotationAssertion( "BTO:0003607") +AnnotationAssertion( "FMA:66783") AnnotationAssertion(rdfs:label "chondroblast") SubClassOf( ) SubClassOf( ) @@ -6059,6 +7325,9 @@ SubClassOf( ObjectSomeValuesFrom( (ciliated cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A cell that has a filiform extrusion of the cell surface.") +AnnotationAssertion( "VHOG:0001532") +AnnotationAssertion( "XAO:0000031") AnnotationAssertion(rdfs:label "ciliated cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6066,7 +7335,12 @@ SubClassOf( ObjectSomeValuesFrom( (epithelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FB:ma") Annotation( "GOC:tfm") Annotation( "MESH:D004847") "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.") +AnnotationAssertion( "BTO:0000414") +AnnotationAssertion( "CALOHA:TS-2026") +AnnotationAssertion( "CARO:0000077") +AnnotationAssertion( "FMA:66768") +AnnotationAssertion( "WBbt:0003672") AnnotationAssertion(rdfs:label "epithelial cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -6074,6 +7348,8 @@ DisjointClasses( (ciliated epithelial cell) +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell that has a cilia.") +AnnotationAssertion( "FMA:70605") AnnotationAssertion(rdfs:label "ciliated epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6081,6 +7357,7 @@ SubClassOf( (duct epithelial cell) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0001-5208-3432") "An epithelial cell that is part of a duct.") AnnotationAssertion(rdfs:label "duct epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6093,7 +7370,7 @@ SubClassOf( (blood vessel endothelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "An endothelial cell that lines the vasculature.") AnnotationAssertion(rdfs:label "blood vessel endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6102,18 +7379,20 @@ SubClassOf( ObjectSomeValuesFrom( (columnar/cuboidal epithelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0002065") Annotation( "https://orcid.org/0000-0001-5208-3432") "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.") AnnotationAssertion(rdfs:label "columnar/cuboidal epithelial cell") SubClassOf( ) # Class: (squamous epithelial cell) +AnnotationAssertion( "CALOHA:TS-1249") AnnotationAssertion(rdfs:label "squamous epithelial cell") SubClassOf( ) # Class: (mesothelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "A flattened epithelial cell of mesenchymal origin that lines the serous cavity.") +AnnotationAssertion( "FMA:66773") AnnotationAssertion(rdfs:label "mesothelial cell") SubClassOf( ) SubClassOf( ) @@ -6121,6 +7400,7 @@ SubClassOf( (circulating cell) +AnnotationAssertion(Annotation( "GOC:add") "A cell which moves among different tissues of the body, via blood, lymph, or other medium.") AnnotationAssertion(rdfs:label "circulating cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6128,6 +7408,9 @@ SubClassOf( ObjectSomeValuesFrom( (blood cell) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") "A cell found predominately in the blood.") +AnnotationAssertion( "FMA:62844") +AnnotationAssertion( "MESH:D001773") AnnotationAssertion(rdfs:label "blood cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6135,14 +7418,30 @@ SubClassOf( ObjectSomeValuesFrom( (epithelial cell of lung) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0001-5208-3432") "An epithelial cell of the lung.") +AnnotationAssertion( "BTO:0004299") AnnotationAssertion(rdfs:label "epithelial cell of lung") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelial cell of pancreas) + +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell of the pancreas.") +AnnotationAssertion( "BTO:0000028") +AnnotationAssertion(rdfs:label "epithelial cell of pancreas") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (T cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") Annotation( "ISBN:0781735149") "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.") +AnnotationAssertion( "BTO:0000782") +AnnotationAssertion( "CALOHA:TS-1001") +AnnotationAssertion( "FMA:62870") +AnnotationAssertion( "MESH:D013601") +AnnotationAssertion( "VHOG:0001479") AnnotationAssertion(rdfs:label "T cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6151,6 +7450,12 @@ SubClassOf( ObjectSomeValuesFrom( (osteoclast) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "ISBN:0781735149") Annotation( "PMID:10428500") Annotation( "PMID:15055519") Annotation( "PMID:17380158") "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.") +AnnotationAssertion( "BTO:0000968") +AnnotationAssertion( "CALOHA:TS-0721") +AnnotationAssertion( "FMA:66781") +AnnotationAssertion( "MESH:D010010") +AnnotationAssertion(rdfs:comment "Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.") AnnotationAssertion(rdfs:label "osteoclast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6168,7 +7473,11 @@ SubClassOf( ObjectSomeValuesFrom( (granulocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:amm") Annotation( "GOC:tfm") Annotation( "MESH:D006098") Annotation( "http://en.wikipedia.org/wiki/Granulocyte") "A leukocyte with abundant granules in the cytoplasm.") +AnnotationAssertion( "BTO:0000539") +AnnotationAssertion( "BTO:0001026") +AnnotationAssertion( "CALOHA:TS-0422") +AnnotationAssertion( "FMA:62854") AnnotationAssertion(rdfs:label "granulocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6191,6 +7500,9 @@ SubClassOf( ObjectSomeValuesFrom( (sensory epithelial cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0517223651") Annotation( "ISBN:0721662544") "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells.") +AnnotationAssertion( "BTO:0004301") +AnnotationAssertion(rdfs:comment "The term \"neuroepithelial cell\" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710).") AnnotationAssertion(rdfs:label "sensory epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6198,19 +7510,29 @@ SubClassOf( (interneuron) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "MESH:D007395") "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.") +AnnotationAssertion( "BTO:0003811") +AnnotationAssertion( "FMA:67313") +AnnotationAssertion( "WBbt:0005113") AnnotationAssertion(rdfs:label "interneuron") SubClassOf( ) # Class: (motor neuron) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:D009046") Annotation( "PMID:16875686") "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement.") +AnnotationAssertion( "BTO:0000312") +AnnotationAssertion( "FMA:83617") +AnnotationAssertion( "WBbt:0005409") AnnotationAssertion(rdfs:label "motor neuron") SubClassOf( ) # Class: (sensory neuron) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0721662544") "Any neuron having a sensory function; an afferent neuron conveying sensory impulses.") +AnnotationAssertion( "BTO:0001037") +AnnotationAssertion( "FMA:84649") +AnnotationAssertion( "MESH:D011984") +AnnotationAssertion( "WBbt:0005759") AnnotationAssertion(rdfs:label "sensory neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6218,6 +7540,8 @@ SubClassOf( ObjectSomeValuesFrom( (autonomic neuron) +AnnotationAssertion(Annotation( "GOC:tfm") "A neuron whose cell body is within an autonomic ganglion.") +AnnotationAssertion( "FMA:80121") AnnotationAssertion(rdfs:label "autonomic neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6225,7 +7549,8 @@ SubClassOf( ObjectSomeValuesFrom( (mononuclear phagocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") Annotation( "ISBN:0781735149") "A vertebrate phagocyte with a single nucleus.") +AnnotationAssertion( "BTO:0001433") AnnotationAssertion(rdfs:label "mononuclear phagocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6233,7 +7558,11 @@ SubClassOf( (endothelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "MESH:D042783") Annotation( "PMID:21275341") Annotation( "http://en.wikipedia.org/wiki/Endothelial_cell") Annotation( "https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855") "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.") +AnnotationAssertion( "BTO:0001176") +AnnotationAssertion( "CALOHA:TS-0278") +AnnotationAssertion( "FMA:66772") +AnnotationAssertion(rdfs:comment "From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].") AnnotationAssertion(rdfs:label "endothelial cell") SubClassOf( ) SubClassOf( ) @@ -6249,24 +7578,37 @@ SubClassOf( ObjectSomeValuesFrom( (glial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:D009457") "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.") +AnnotationAssertion( "BTO:0002606") +AnnotationAssertion( "CALOHA:TS-0415") +AnnotationAssertion( "FMA:54536") +AnnotationAssertion(rdfs:comment "Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571") AnnotationAssertion(rdfs:label "glial cell") SubClassOf( ) # Class: (neurectodermal cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:068340007X") "Ectoderm destined to be nervous tissue.") AnnotationAssertion(rdfs:label "neurectodermal cell") SubClassOf( ) # Class: (mesenchymal stem cell) +AnnotationAssertion(Annotation( "FB:ma") Annotation( "GOC:dsd") Annotation( "PMCID:PMC2613570") Annotation( "PMID:10102814") Annotation( "PMID:16923606") Annotation( "PMID:17986482") Annotation( "PMID:19960544") Annotation( "http://en.wikipedia.org/wiki/Mesenchymal_stem_cell") Annotation( "http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells") "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.") +AnnotationAssertion( "BTO:0002625") +AnnotationAssertion( "BTO:0003298") +AnnotationAssertion( "FMA:70546") +AnnotationAssertion(rdfs:comment "Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.") AnnotationAssertion(rdfs:label "mesenchymal stem cell") SubClassOf( ) SubClassOf( ) # Class: (adipocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:D017667") "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.") +AnnotationAssertion( "BTO:0000443") +AnnotationAssertion( "CALOHA:TS-0012") +AnnotationAssertion( "FMA:63880") AnnotationAssertion(rdfs:label "adipocyte") SubClassOf( ) SubClassOf( ) @@ -6275,6 +7617,10 @@ SubClassOf( ObjectSomeValuesFrom( (chondrocyte) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "MESH:D019902") "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell.") +AnnotationAssertion( "BTO:0000249") +AnnotationAssertion( "CALOHA:TS-0138") +AnnotationAssertion( "FMA:66782") AnnotationAssertion(rdfs:label "chondrocyte") SubClassOf( ) SubClassOf( ) @@ -6283,6 +7629,8 @@ SubClassOf( ObjectSomeValuesFrom( (professional antigen presenting cell) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response.") +AnnotationAssertion(rdfs:comment "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.") AnnotationAssertion(rdfs:label "professional antigen presenting cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6290,6 +7638,8 @@ SubClassOf( ObjectSomeValuesFrom( (pigment cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A pigment cell is a cell that contains pigment granules.") +AnnotationAssertion( "VHOG:0001678") AnnotationAssertion(rdfs:label "pigment cell") SubClassOf( ) @@ -6300,6 +7650,9 @@ SubClassOf( (glandular epithelial cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules.") +AnnotationAssertion( "CALOHA:TS-2085") +AnnotationAssertion( "FMA:86494") AnnotationAssertion(rdfs:label "glandular epithelial cell") SubClassOf( ) SubClassOf( ) @@ -6307,6 +7660,9 @@ SubClassOf( ObjectSomeValuesFrom( (secretory cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "A cell that specializes in controlled release of one or more substances.") +AnnotationAssertion( "BTO:0003659") +AnnotationAssertion( "FMA:86916") AnnotationAssertion(rdfs:label "secretory cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6314,6 +7670,8 @@ SubClassOf( ObjectSomeValuesFrom( (exocrine cell) +AnnotationAssertion(Annotation( "ISBN:0198547684") "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct.") +AnnotationAssertion( "FMA:16014") AnnotationAssertion(rdfs:label "exocrine cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6321,12 +7679,14 @@ SubClassOf( ObjectSomeValuesFrom( (glycosaminoglycan secreting cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A cell that secretes glycosaminoglycans.") AnnotationAssertion(rdfs:label "glycosaminoglycan secreting cell") SubClassOf( ) SubClassOf( ) # Class: (protein secreting cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any secretory cell that is capable of some protein secretion.") AnnotationAssertion(rdfs:label "protein secreting cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6334,6 +7694,7 @@ SubClassOf( ObjectSomeValuesFrom( (surfactant secreting cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "A cell that specializes in secretion of surfactant in the alveoli of the lung.") AnnotationAssertion(rdfs:label "surfactant secreting cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6341,7 +7702,9 @@ SubClassOf( ObjectSomeValuesFrom( (club cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "DOI:10.1183/09031936.00146609") Annotation( "DOI:10.1378/chest.12-2762") Annotation( "GOC:tfm") Annotation( "PMID:28128362") Annotation( "PMID:29874100") Annotation( "PMID:7905712") "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium.") +AnnotationAssertion( "BTO:0004811") +AnnotationAssertion( "FMA:14119") AnnotationAssertion(rdfs:label "club cell") SubClassOf( ) SubClassOf( ) @@ -6355,7 +7718,8 @@ SubClassOf( (endocrine cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:D055098") "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.") +AnnotationAssertion( "FMA:83809") AnnotationAssertion(rdfs:label "endocrine cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) @@ -6364,13 +7728,22 @@ SubClassOf( ObjectSomeValuesFrom( (enteroendocrine cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "SANBI:mhl") "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas.") +AnnotationAssertion( "BTO:0003865") +AnnotationAssertion( "FMA:62930") +AnnotationAssertion( "MESH:D019858") AnnotationAssertion(rdfs:label "enteroendocrine cell") SubClassOf( ) SubClassOf( ) # Class: (neuroendocrine cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:D055099") "A neuron that is capable of some hormone secretion in response to neuronal signals.") +AnnotationAssertion( "BTO:0002691") +AnnotationAssertion( "FMA:83810") +AnnotationAssertion(Annotation( "PMID:5342440") Annotation( "https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073") rdfs:comment "The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. + +The modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron.") AnnotationAssertion(rdfs:label "neuroendocrine cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6379,39 +7752,118 @@ SubClassOf( (peptide hormone secreting cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any secretory cell that is capable of some peptide hormone secretion.") AnnotationAssertion(rdfs:label "peptide hormone secreting cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (insulin secreting cell) + +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any secretory cell that is capable of some insulin secretion.") +AnnotationAssertion( "BTO:0000783") +AnnotationAssertion(rdfs:label "insulin secreting cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (type B pancreatic cell) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0517223651") Annotation( "http://en.wikipedia.org/wiki/Pancreatic_b_cell") "A cell that secretes insulin and is located towards the center of the islets of Langerhans.") +AnnotationAssertion( "BTO:0000783") +AnnotationAssertion( "EV:0200009") +AnnotationAssertion( "FMA:70586") +AnnotationAssertion( "MA:0002419") +AnnotationAssertion( "ncithesaurus:Beta_Cell") +AnnotationAssertion(rdfs:comment "Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression.") +AnnotationAssertion(rdfs:label "type B pancreatic cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (glucagon secreting cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A cell that secretes glucagon.") +AnnotationAssertion( "FMA:84045") AnnotationAssertion(rdfs:label "glucagon secreting cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreatic A cell) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon.") +AnnotationAssertion( "BTO:0000990") +AnnotationAssertion( "FMA:70585") +AnnotationAssertion( "MESH:D050416") +AnnotationAssertion(rdfs:label "pancreatic A cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (somatostatin secreting cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any secretory cell that is capable of some somatostatin secretion.") AnnotationAssertion(rdfs:label "somatostatin secreting cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreatic D cell) + +AnnotationAssertion(Annotation( "FMA:0517223651") Annotation( "GOC:tfm") "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin.") +AnnotationAssertion( "BTO:0000803") +AnnotationAssertion( "FMA:70587") +AnnotationAssertion(rdfs:label "pancreatic D cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (steroid hormone secreting cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any secretory cell that is capable of some steroid hormone secretion.") AnnotationAssertion(rdfs:label "steroid hormone secreting cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepatocyte) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0412046911") Annotation( "MESH:D022781") Annotation( "PMID:19717280") Annotation( "http://en.wikipedia.org/wiki/Hepatocyte") "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated.") +AnnotationAssertion( "BTO:0000575") +AnnotationAssertion( "CALOHA:TS-0454") +AnnotationAssertion( "FMA:14515") +AnnotationAssertion(rdfs:comment "Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive.") +AnnotationAssertion(rdfs:label "hepatocyte") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (contractile cell) +AnnotationAssertion(Annotation( "FB:ma") "A cell whose primary function is to shorten.") AnnotationAssertion(rdfs:label "contractile cell") SubClassOf( ) # Class: (muscle cell) +AnnotationAssertion(Annotation( "MESH:D032342") "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.") +AnnotationAssertion( "BTO:0000888") +AnnotationAssertion( "BTO:0000902") +AnnotationAssertion( "CALOHA:TS-2032") +AnnotationAssertion( "FMA:67328") +AnnotationAssertion( "WBbt:0003675") AnnotationAssertion(rdfs:label "muscle cell") SubClassOf( ) SubClassOf( ) @@ -6420,7 +7872,10 @@ SubClassOf( ObjectSomeValuesFrom( (cell of skeletal muscle) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "A somatic cell located in skeletal muscle.") +AnnotationAssertion( "BTO:0004392") +AnnotationAssertion( "CALOHA:TS-2158") +AnnotationAssertion( "FMA:9727") AnnotationAssertion(rdfs:label "cell of skeletal muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6428,7 +7883,10 @@ SubClassOf( ObjectSomeValuesFrom( (smooth muscle cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:D032389") Annotation( "PMID:9315361") Annotation( "http://en.wikipedia.org/wiki/Smooth_muscle_cell") "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast).") +AnnotationAssertion( "BTO:0004576") +AnnotationAssertion( "CALOHA:TS-2159") +AnnotationAssertion( "FMA:14072") AnnotationAssertion(rdfs:label "smooth muscle cell") SubClassOf( ) SubClassOf( ) @@ -6437,6 +7895,7 @@ SubClassOf( ObjectSomeValuesFrom( (sensory receptor cell) AnnotationAssertion( "A cell that is capable of detection of a stimulus involved in sensory perception.") +AnnotationAssertion( "MESH:D011984") AnnotationAssertion(rdfs:label "sensory receptor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6445,6 +7904,7 @@ SubClassOf( ObjectSomeValuesFrom( (chemoreceptor cell) +AnnotationAssertion(Annotation( "MESH:D002628") "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood.") AnnotationAssertion(rdfs:label "chemoreceptor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6452,6 +7912,10 @@ SubClassOf( ObjectSomeValuesFrom( (photoreceptor cell) +AnnotationAssertion(Annotation( "MESH:D010786") "A cell specialized to detect and transduce light.") +AnnotationAssertion( "BTO:0001060") +AnnotationAssertion( "CALOHA:TS-0868") +AnnotationAssertion( "FMA:86740") AnnotationAssertion(rdfs:label "photoreceptor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6459,17 +7923,20 @@ SubClassOf( ObjectSomeValuesFrom( (electrically active cell) +AnnotationAssertion(Annotation( "FB:ma") "A cell whose function is determined by the generation or the reception of an electric signal.") AnnotationAssertion(rdfs:label "electrically active cell") SubClassOf( ) # Class: (lining cell) +AnnotationAssertion(Annotation( "JB:jb") "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism.") AnnotationAssertion(rdfs:label "lining cell") SubClassOf( ) # Class: (synovial cell) AnnotationAssertion( "A cell located in the synovial joint.") +AnnotationAssertion( "CALOHA:TS-0995") AnnotationAssertion(rdfs:label "synovial cell") SubClassOf( ) SubClassOf( ) @@ -6477,11 +7944,13 @@ SubClassOf( ObjectSomeValuesFrom( (barrier cell) +AnnotationAssertion(Annotation( "JB:jb") "A cell whose primary function is to prevent the transport of stuff across compartments.") AnnotationAssertion(rdfs:label "barrier cell") SubClassOf( ) # Class: (motile cell) +AnnotationAssertion(Annotation( "FB:ma") "A cell that moves by its own activities.") AnnotationAssertion(rdfs:label "motile cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6489,24 +7958,31 @@ SubClassOf( ObjectSomeValuesFrom( (ectodermal cell) +AnnotationAssertion(Annotation( "MESH:D004475") "A cell of the outer of the three germ layers of the embryo.") +AnnotationAssertion( "FMA:72549") AnnotationAssertion(rdfs:label "ectodermal cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (mesodermal cell) +AnnotationAssertion(Annotation( "MESH:D008648") "A cell of the middle germ layer of the embryo.") +AnnotationAssertion( "FMA:72554") AnnotationAssertion(rdfs:label "mesodermal cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (endodermal cell) +AnnotationAssertion(Annotation( "MESH:D004707") "A cell of the inner of the three germ layers of the embryo.") +AnnotationAssertion( "FMA:72555") AnnotationAssertion(rdfs:label "endodermal cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (single nucleate cell) +AnnotationAssertion(Annotation( "FB:ma") Annotation( "GOC:tfm") "A cell with a single nucleus.") AnnotationAssertion(rdfs:label "single nucleate cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6514,6 +7990,9 @@ SubClassOf( ObjectSomeValuesFrom( (multinucleate cell) +AnnotationAssertion(Annotation( "FB:ma") "A cell with more than one nucleus.") +AnnotationAssertion( "AEO:0000203") +AnnotationAssertion( "WBbt:0008074") AnnotationAssertion(rdfs:label "multinucleate cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6521,7 +8000,10 @@ SubClassOf( ObjectSomeValuesFrom( (erythrocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "MESH:D004912") "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.") +AnnotationAssertion( "BTO:0000424") +AnnotationAssertion( "CALOHA:TS-0290") +AnnotationAssertion( "FMA:81100") AnnotationAssertion(rdfs:label "erythrocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6534,6 +8016,10 @@ SubClassOf( ObjectSomeValuesFrom( (phagocyte) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0721601464") "Any cell capable of ingesting particulate matter via phagocytosis.") +AnnotationAssertion( "BTO:0001044") +AnnotationAssertion( "FMA:83806") +AnnotationAssertion( "MESH:D010586") AnnotationAssertion(rdfs:label "phagocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6543,7 +8029,13 @@ SubClassOf( ObjectSomeValuesFrom( (macrophage) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "PMID:16213494") Annotation( "PMID:1919437") "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.") +AnnotationAssertion( "BTO:0000801") +AnnotationAssertion( "CALOHA:TS-0587") +AnnotationAssertion( "FMA:63261") +AnnotationAssertion( "FMA:83585") +AnnotationAssertion( "MESH:D008264") +AnnotationAssertion(rdfs:comment "Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.") AnnotationAssertion(rdfs:label "macrophage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6554,6 +8046,8 @@ SubClassOf( ObjectSomeValuesFrom( (eukaryotic cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any cell that only exists in Eukaryota.") +AnnotationAssertion( "MESH:D005057") AnnotationAssertion(rdfs:label "eukaryotic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6561,6 +8055,7 @@ SubClassOf( ObjectSomeValuesFrom( (Eumycetozoan cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any cell that only exists in Eumycetozoa.") AnnotationAssertion(rdfs:label "Eumycetozoan cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6568,7 +8063,7 @@ SubClassOf( ObjectSomeValuesFrom( (eye photoreceptor cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any photoreceptor cell that is part of some eye.") AnnotationAssertion(rdfs:label "eye photoreceptor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6576,11 +8071,15 @@ SubClassOf( ObjectSomeValuesFrom( (structural cell) +AnnotationAssertion(Annotation( "TAIR:sr") "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism.") AnnotationAssertion(rdfs:label "structural cell") SubClassOf( ) # Class: (gamete) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "A mature sexual reproductive cell having a single set of unpaired chromosomes.") +AnnotationAssertion( "CALOHA:TS-0395") +AnnotationAssertion( "FMA:18649") AnnotationAssertion(rdfs:label "gamete") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6594,6 +8093,9 @@ SubClassOf( (tracheal epithelial cell) +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell found in the trachea.") +AnnotationAssertion( "FMA:74793") +AnnotationAssertion(rdfs:comment "This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'") AnnotationAssertion(rdfs:label "tracheal epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6602,11 +8104,27 @@ SubClassOf( ObjectSomeValuesFrom( (serous secreting cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0517223651") Annotation( "ISBN:0721662544") "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid.") +AnnotationAssertion( "BTO:0003687") +AnnotationAssertion( "FMA:62511") AnnotationAssertion(rdfs:label "serous secreting cell") SubClassOf( ) +# Class: (mucus secreting cell) + +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any secretory cell that is capable of some mucus secretion.") +AnnotationAssertion( "BTO:0003689") +AnnotationAssertion(rdfs:label "mucus secreting cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (pulmonary alveolar epithelial cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:20054144") Annotation( "PMID:29463737") "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates.") +AnnotationAssertion( "BTO:0000395") +AnnotationAssertion( "CALOHA:TS-2168") +AnnotationAssertion( "FMA:62499") AnnotationAssertion(rdfs:label "pulmonary alveolar epithelial cell") SubClassOf( ) SubClassOf( ) @@ -6614,6 +8132,7 @@ SubClassOf( ObjectSomeValuesFrom( (stuff accumulating cell) +AnnotationAssertion(Annotation( "FB:ma") "A cell that is specialised to accumulate a particular substance(s).") AnnotationAssertion(rdfs:label "stuff accumulating cell") SubClassOf( ) @@ -6624,6 +8143,7 @@ SubClassOf( (oxygen accumulating cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any cell that is capable of some oxygen transport.") AnnotationAssertion(rdfs:label "oxygen accumulating cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6631,6 +8151,8 @@ SubClassOf( ObjectSomeValuesFrom( (migratory neural crest cell) +AnnotationAssertion(Annotation( "doi:10.1016/j.stem.2015.02.017") "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body.") +AnnotationAssertion( "FMA:86667") AnnotationAssertion(rdfs:label "migratory neural crest cell") SubClassOf( ) SubClassOf( ) @@ -6639,11 +8161,13 @@ SubClassOf( ObjectSomeValuesFrom( (mesenchyme condensation cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:5025404") "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors.") AnnotationAssertion(rdfs:label "mesenchyme condensation cell") SubClassOf( ) # Class: (scleral cell) +AnnotationAssertion(Annotation( "GOC:add") "A cell of the sclera of the eye.") AnnotationAssertion(rdfs:label "scleral cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6653,6 +8177,7 @@ SubClassOf( ObjectSomeValuesFrom( (choroidal cell of the eye) +AnnotationAssertion(Annotation( "GOC:add") "A structural cell that is part of optic choroid.") AnnotationAssertion(rdfs:label "choroidal cell of the eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6662,6 +8187,7 @@ SubClassOf( ObjectSomeValuesFrom( (extraembryonic cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any cell that is part of some extraembryonic structure.") AnnotationAssertion(rdfs:label "extraembryonic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6669,30 +8195,47 @@ SubClassOf( ObjectSomeValuesFrom( (trophoblast cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "MESH:D014327") "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface.") +AnnotationAssertion( "FMA:83028") AnnotationAssertion(rdfs:label "trophoblast cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (epiblast cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0618947256") "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation.") AnnotationAssertion(rdfs:label "epiblast cell") SubClassOf( ) # Class: (blastoderm cell) +AnnotationAssertion(Annotation( "MESH:D001756") "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote).") +AnnotationAssertion( "BTO:0001473") +AnnotationAssertion( "FMA:72551") AnnotationAssertion(rdfs:label "blastoderm cell") SubClassOf( ) # Class: (multi-potent skeletal muscle stem cell) +AnnotationAssertion(Annotation( "PMID:18282570") "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell.") +AnnotationAssertion( "FMA:86767") +AnnotationAssertion(rdfs:comment "Multi-potency demonstrated ex vivo. At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo.") AnnotationAssertion(rdfs:label "multi-potent skeletal muscle stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (sphincter associated smooth muscle cell) + +AnnotationAssertion(Annotation( "GOC:cjm") "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.") +AnnotationAssertion(rdfs:label "sphincter associated smooth muscle cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vascular associated smooth muscle cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:dsd") Annotation( "GOC:tfm") "A smooth muscle cell associated with the vasculature.") AnnotationAssertion(rdfs:label "vascular associated smooth muscle cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6701,6 +8244,11 @@ SubClassOf( ObjectSomeValuesFrom( (epidermal cell) +AnnotationAssertion(Annotation( "Flybase:dsj") Annotation( "MA:ma") "An epithelial cell of the integument (the outer layer of an organism).") +AnnotationAssertion( "BTO:0001470") +AnnotationAssertion( "CALOHA:TS-0283") +AnnotationAssertion( "FMA:62411") +AnnotationAssertion( "MESH:D000078404") AnnotationAssertion(rdfs:label "epidermal cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6708,6 +8256,10 @@ SubClassOf( ObjectSomeValuesFrom( (animal zygote) +AnnotationAssertion(Annotation( "ISBN:0471245208") "Diploid cell produced by the fusion of sperm cell nucleus and egg cell.") +AnnotationAssertion( "BTO:0000854") +AnnotationAssertion( "EHDAA2:0004546") +AnnotationAssertion( "FMA:72395") AnnotationAssertion(rdfs:label "animal zygote") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6722,11 +8274,13 @@ SubClassOf( (electrically responsive cell) +AnnotationAssertion(Annotation( "FB:ma") "A cell whose function is determined by its response to an electric signal.") AnnotationAssertion(rdfs:label "electrically responsive cell") SubClassOf( ) # Class: (ganglion interneuron) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any interneuron that has its soma located in some ganglion.") AnnotationAssertion(rdfs:label "ganglion interneuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6734,7 +8288,8 @@ SubClassOf( ObjectSomeValuesFrom( (CNS interneuron) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "doi:10.1016/B978-0-12-817424-1.00001-X") "An interneuron that has its cell body in a central nervous system.") +AnnotationAssertion(rdfs:comment "Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system.") AnnotationAssertion(rdfs:label "CNS interneuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6742,16 +8297,31 @@ SubClassOf( (electrically signaling cell) +AnnotationAssertion(Annotation( "FB:ma") "A cell that initiates an electrical signal and passes that signal to another cell.") AnnotationAssertion(rdfs:label "electrically signaling cell") SubClassOf( ) +# Class: (polyploid cell) + +AnnotationAssertion(Annotation( "https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy"^^xsd:anyURI) Annotation( "FB:ma") Annotation( "PMID:32646579") "A cell that contains more than two haploid sets of chromosomes.") +AnnotationAssertion(rdfs:label "polyploid cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (haploid cell) +AnnotationAssertion(Annotation( "FB:ma") Annotation( "GOC:tfm") "A cell whose nucleus contains a single haploid genome.") AnnotationAssertion(rdfs:label "haploid cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (endopolyploid cell) + +AnnotationAssertion(rdfs:label "endopolyploid cell") +SubClassOf( ) + # Class: (carbohydrate secreting cell) AnnotationAssertion(rdfs:label "carbohydrate secreting cell") @@ -6759,7 +8329,11 @@ SubClassOf( (dendritic cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).") +AnnotationAssertion( "BTO:0002042") +AnnotationAssertion( "CALOHA:TS-0194") +AnnotationAssertion( "FMA:83036") +AnnotationAssertion( "MESH:D003713") AnnotationAssertion(rdfs:label "dendritic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6781,6 +8355,7 @@ SubClassOf( (serotonin secreting cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:19630576") "A cell type that secretes 5-Hydroxytryptamine (serotonin).") AnnotationAssertion(rdfs:label "serotonin secreting cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6788,6 +8363,7 @@ SubClassOf( ObjectSomeValuesFrom( (noradrenergic cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:068340007X") "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme.") AnnotationAssertion(rdfs:label "noradrenergic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6795,11 +8371,13 @@ SubClassOf( ObjectSomeValuesFrom( (defensive cell) +AnnotationAssertion(Annotation( "JB:jb") "A cell whose primary function is to protect the organism.") AnnotationAssertion(rdfs:label "defensive cell") SubClassOf( ) # Class: (visible light photoreceptor cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A photoreceptor cell that detects visible light.") AnnotationAssertion(rdfs:label "visible light photoreceptor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6807,14 +8385,56 @@ SubClassOf( ObjectSomeValuesFrom( (stromal cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "MESH:D017154") "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.") +AnnotationAssertion( "BTO:0002064") +AnnotationAssertion( "FMA:83624") AnnotationAssertion(rdfs:label "stromal cell") SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (type D enteroendocrine cell) + +AnnotationAssertion(Annotation( "MESH:D019864") "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin.") +AnnotationAssertion( "FMA:62935") +AnnotationAssertion(rdfs:label "type D enteroendocrine cell") +SubClassOf( ) +SubClassOf( ) + +# Class: (enkephalin secreting cell) + +AnnotationAssertion(Annotation( "GO:tfm") "An endorphine cell that secretes enkephalin.") +AnnotationAssertion(rdfs:label "enkephalin secreting cell") +SubClassOf( ) + +# Class: (endorphin secreting cell) + +AnnotationAssertion(Annotation( "GO:tfm") "A peptide hormone secreting cell that secretes endorphin.") +AnnotationAssertion(rdfs:label "endorphin secreting cell") +SubClassOf( ) + +# Class: (type G enteroendocrine cell) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0517223651") Annotation( "MESH:D019863") "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli.") +AnnotationAssertion( "BTO:0004108") +AnnotationAssertion( "FMA:67609") +AnnotationAssertion(rdfs:label "type G enteroendocrine cell") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (gastrin secreting cell) + +AnnotationAssertion(Annotation( "GO:tfm") "A peptide hormone secreting cell that secretes gastrin.") +AnnotationAssertion(rdfs:label "gastrin secreting cell") +SubClassOf( ) + # Class: (cardiac muscle myoblast) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "MESH:D032386") "A precursor cell destined to differentiate into cardiac muscle cell.") +AnnotationAssertion( "FMA:84797") AnnotationAssertion(rdfs:label "cardiac muscle myoblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6823,6 +8443,8 @@ SubClassOf( ObjectSomeValuesFrom( (smooth muscle myoblast) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "MESH:D032390") "A precursor cell destined to differentiate into smooth muscle myocytes.") +AnnotationAssertion( "FMA:84798") AnnotationAssertion(rdfs:label "smooth muscle myoblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6830,6 +8452,8 @@ SubClassOf( ObjectSomeValuesFrom( (skeletal muscle myoblast) +AnnotationAssertion(Annotation( "SANBI:mhl") "A myoblast that differentiates into skeletal muscle fibers.") +AnnotationAssertion( "FMA:84799") AnnotationAssertion(rdfs:label "skeletal muscle myoblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6839,6 +8463,7 @@ SubClassOf( ObjectSomeValuesFrom( (phagocyte (sensu Vertebrata)) +AnnotationAssertion(Annotation( "GOC:tfm") "A phagocyte in vertebrates that is able to phagocytosis.") AnnotationAssertion(rdfs:label "phagocyte (sensu Vertebrata)") SubClassOf( ) SubClassOf( ) @@ -6846,6 +8471,7 @@ SubClassOf( ObjectSomeValuesFrom( (fungal cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any cell that only exists in Fungi.") AnnotationAssertion(rdfs:label "fungal cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6853,7 +8479,8 @@ SubClassOf( ObjectSomeValuesFrom( (syncytiotrophoblast cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0323052908") "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.") +AnnotationAssertion( "FMA:83043") AnnotationAssertion(rdfs:label "syncytiotrophoblast cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6862,18 +8489,26 @@ SubClassOf( ObjectSomeValuesFrom( (afferent neuron) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "MESH:D009475") "A neuron which conveys sensory information centrally from the periphery.") +AnnotationAssertion( "FMA:87653") AnnotationAssertion(rdfs:label "afferent neuron") SubClassOf( ) # Class: (efferent neuron) +AnnotationAssertion(Annotation( "MESH:D009476") "A neuron which sends impulses peripherally to activate muscles or secretory cells.") AnnotationAssertion(rdfs:label "efferent neuron") SubClassOf( ) # Class: (neuron) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:D009474") Annotation( "http://en.wikipedia.org/wiki/Neuron") "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.") +AnnotationAssertion( "BTO:0000938") +AnnotationAssertion( "CALOHA:TS-0683") +AnnotationAssertion( "FMA:54527") +AnnotationAssertion( "VHOG:0001483") +AnnotationAssertion( "WBbt:0003679") +AnnotationAssertion(rdfs:comment "These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.") AnnotationAssertion(rdfs:label "neuron") SubClassOf( ) SubClassOf( ) @@ -6882,7 +8517,13 @@ SubClassOf( ObjectSomeValuesFrom( (lymphocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0683073696") Annotation( "ISBN:0781735149") "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.") +AnnotationAssertion( "BTO:0000775") +AnnotationAssertion( "CALOHA:TS-0583") +AnnotationAssertion( "FMA:62863") +AnnotationAssertion( "MESH:D008214") +AnnotationAssertion( "VHOG:0001535") +AnnotationAssertion(rdfs:comment "Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)") AnnotationAssertion(rdfs:label "lymphocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6894,6 +8535,8 @@ DisjointClasses( (proerythroblast) +AnnotationAssertion(Annotation( "ISBN:0721601464") Annotation( "PMID:1638021") "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.") +AnnotationAssertion( "FMA:83518") AnnotationAssertion(rdfs:label "proerythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6917,6 +8560,8 @@ SubClassOf( ObjectSomeValuesFrom( (basophilic erythroblast) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721601464") "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers.") +AnnotationAssertion( "FMA:83505") AnnotationAssertion(rdfs:label "basophilic erythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6926,6 +8571,8 @@ SubClassOf( ObjectSomeValuesFrom( (polychromatophilic erythroblast) +AnnotationAssertion(Annotation( "ISBN:0721601464") "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers.") +AnnotationAssertion( "FMA:83506") AnnotationAssertion(rdfs:label "polychromatophilic erythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6936,6 +8583,8 @@ SubClassOf( ObjectSomeValuesFrom( (orthochromatic erythroblast) +AnnotationAssertion(Annotation( "ISBN:0721601464") "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated.") +AnnotationAssertion( "FMA:84646") AnnotationAssertion(rdfs:label "orthochromatic erythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6945,7 +8594,12 @@ SubClassOf( ObjectSomeValuesFrom( (megakaryocyte progenitor cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:dsd") Annotation( "GOC:tfm") Annotation( "ISBN:0721601464") "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).") +AnnotationAssertion( "BTO:0001164") +AnnotationAssertion( "CALOHA:TS-0610") +AnnotationAssertion( "FMA:84235") +AnnotationAssertion( "MESH:D055016") +AnnotationAssertion(rdfs:comment "Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.") AnnotationAssertion(rdfs:label "megakaryocyte progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6968,7 +8622,11 @@ SubClassOf( ObjectSomeValuesFrom( (megakaryocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0721601464") Annotation( "MESH:D008533") Annotation( "PMID:31043076") Annotation( "http://en.wikipedia.org/wiki/Megakaryocyte") "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release.") +AnnotationAssertion( "BTO:0000843") +AnnotationAssertion( "CALOHA:TS-0611") +AnnotationAssertion( "FMA:83555") +AnnotationAssertion(rdfs:comment "Megakaryocytes are reportedly CD181-positive and CD182-positive.") AnnotationAssertion(rdfs:label "megakaryocyte") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -6977,7 +8635,8 @@ DisjointClasses( (granulocyte monocyte progenitor cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:amm") Annotation( "GOC:dsd") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "ISBN:0721601464") Annotation( "MESH:D055014") Annotation( "PMCID:PMC2213186") Annotation( "PMCID:PMC548021") Annotation( "PMID:16551251") Annotation( "PMID:16647566") Annotation( "http://en.wikipedia.org/wiki/CFU-GM") Annotation( "http://www.copewithcytokines.de") "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.") +AnnotationAssertion(rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.") AnnotationAssertion(rdfs:label "granulocyte monocyte progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -6994,6 +8653,10 @@ SubClassOf( ObjectSomeValuesFrom( (reticulocyte) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") Annotation( "PMID:15946868") Annotation( "PMID:2037622") "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds.") +AnnotationAssertion( "BTO:0001173") +AnnotationAssertion( "CALOHA:TS-0864") +AnnotationAssertion( "MESH:D012156") AnnotationAssertion(rdfs:label "reticulocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7014,7 +8677,10 @@ SubClassOf( ObjectSomeValuesFrom( (promonocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721601464") "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules.") +AnnotationAssertion( "BTO:0004657") +AnnotationAssertion( "FMA:83551") +AnnotationAssertion(rdfs:comment "Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.") AnnotationAssertion(rdfs:label "promonocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7025,6 +8691,7 @@ SubClassOf( ObjectSomeValuesFrom( (nucleate erythrocyte) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOc:tfm") "An erythrocyte having a nucleus.") AnnotationAssertion(rdfs:label "nucleate erythrocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7033,6 +8700,8 @@ SubClassOf( ObjectSomeValuesFrom( (angioblastic mesenchymal cell) +AnnotationAssertion(Annotation( "GOC:dsd") Annotation( "GOC:tfm") Annotation( "PMID:12768659") "A mesenchymal stem cell capable of developing into blood vessel endothelium.") +AnnotationAssertion(rdfs:comment "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.") AnnotationAssertion(rdfs:label "angioblastic mesenchymal cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7044,6 +8713,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac mesenchymal cell) +AnnotationAssertion(Annotation( "PMID:18816864") "A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field.") AnnotationAssertion(rdfs:label "cardiac mesenchymal cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7052,14 +8722,20 @@ SubClassOf( ObjectSomeValuesFrom( (retinal cone cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:D017949") "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.") +AnnotationAssertion( "BTO:0001036") +AnnotationAssertion( "CALOHA:TS-0866") +AnnotationAssertion( "FMA:67748") AnnotationAssertion(rdfs:label "retinal cone cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (corneal epithelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell of the cornea.") +AnnotationAssertion( "BTO:0004298") +AnnotationAssertion( "CALOHA:TS-0173") +AnnotationAssertion( "FMA:70551") AnnotationAssertion(rdfs:label "corneal epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7068,7 +8744,11 @@ SubClassOf( ObjectSomeValuesFrom( (monocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO_REF:0000031") Annotation( "MESH:D009000") "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.") +AnnotationAssertion( "BTO:0000876") +AnnotationAssertion( "CALOHA:TS-0638") +AnnotationAssertion( "FMA:62864") +AnnotationAssertion(rdfs:comment "Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.") AnnotationAssertion(rdfs:label "monocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7081,7 +8761,11 @@ SubClassOf( ObjectSomeValuesFrom( (alveolar macrophage) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:ana") Annotation( "GOC:dsd") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "MESH:D016676") "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative.") +AnnotationAssertion( "BTO:0000802") +AnnotationAssertion( "CALOHA:TS-0030") +AnnotationAssertion( "FMA:83023") +AnnotationAssertion(rdfs:comment "Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-.") AnnotationAssertion(rdfs:label "alveolar macrophage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7098,12 +8782,18 @@ SubClassOf( ObjectSomeValuesFrom( (germ cell) +AnnotationAssertion(Annotation( "MESH:D005854") "The reproductive cell in multicellular organisms.") +AnnotationAssertion( "BTO:0000535") +AnnotationAssertion( "NCIT:C12597") +AnnotationAssertion( "VHOG:0001534") +AnnotationAssertion( "WBbt:0006796") AnnotationAssertion(rdfs:label "germ cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (androgen secreting cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A steroid hormone secreting cell that secretes androgen.") AnnotationAssertion(rdfs:label "androgen secreting cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7111,24 +8801,51 @@ SubClassOf( ObjectSomeValuesFrom( (retinal rod cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:D017948") "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision.") +AnnotationAssertion( "BTO:0001024") +AnnotationAssertion( "CALOHA:TS-0870") +AnnotationAssertion( "FMA:67747") AnnotationAssertion(rdfs:label "retinal rod cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (acinar cell) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "http://www.copewithcytokines.de") "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus).") +AnnotationAssertion( "FMA:83625") +AnnotationAssertion( "MESH:D061354") +AnnotationAssertion(rdfs:label "acinar cell") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (supporting cell) +AnnotationAssertion(Annotation( "FB:ma") Annotation( "GOC:tfm") "A cell whose primary function is to support other cell types.") +AnnotationAssertion( "BTO:0002315") AnnotationAssertion(rdfs:label "supporting cell") SubClassOf( ) +# Class: (fenestrated endothelial cell) + +AnnotationAssertion(Annotation( "DOI:10.1007/978-3-211-99390-3_133") "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues.") +AnnotationAssertion(rdfs:label "fenestrated endothelial cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (collagen secreting cell) +AnnotationAssertion(Annotation( "GOC:tfm") "An extracellular matrix secreting cell that secretes collagen.") AnnotationAssertion(rdfs:label "collagen secreting cell") SubClassOf( ) # Class: (pericyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:dsd") Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") Annotation( "MESH:D020286") Annotation( "PMID:16807374") Annotation( "PMID:17986482") Annotation( "PMID:20024907") "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells.") +AnnotationAssertion( "BTO:0002441") +AnnotationAssertion( "FMA:63174") +AnnotationAssertion(rdfs:comment "Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A.") AnnotationAssertion(rdfs:label "pericyte") SubClassOf( ) SubClassOf( ) @@ -7137,6 +8854,8 @@ SubClassOf( (primordial germ cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:1381289") "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells.") +AnnotationAssertion( "FMA:70567") AnnotationAssertion(rdfs:label "primordial germ cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7145,12 +8864,14 @@ SubClassOf( ObjectSomeValuesFrom( (female gamete) +AnnotationAssertion(Annotation( "GOC:tfm") "A mature sexual reproductive cell of the female germline.") AnnotationAssertion(rdfs:label "female gamete") SubClassOf( ) SubClassOf( ) # Class: (muscle precursor cell) +AnnotationAssertion(Annotation( "GOC:add") "A non-terminally differentiated cell that is capable of developing into a muscle cell.") AnnotationAssertion(rdfs:label "muscle precursor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7160,12 +8881,19 @@ SubClassOf( ObjectSomeValuesFrom( (PP cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "JB:jb") Annotation( "PMID:15153415") "A cell that stores and secretes pancreatic polypeptide hormone.") +AnnotationAssertion( "FMA:62938") +AnnotationAssertion( "FMA:83409") AnnotationAssertion(rdfs:label "PP cell") SubClassOf( ) SubClassOf( ) # Class: (neurecto-epithelial cell) +AnnotationAssertion(Annotation( "GOC:tfm") "Epithelial cells derived from neural plate and neural crest.") +AnnotationAssertion( "BTO:0004301") +AnnotationAssertion( "FMA:70557") +AnnotationAssertion(rdfs:comment "The term \"neuroepithelial cell\" is used to describe both this cell type and sensory epithelial cell (CL:0000098).") AnnotationAssertion(rdfs:label "neurecto-epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7174,6 +8902,9 @@ SubClassOf( ObjectSomeValuesFrom( (somatic stem cell) +AnnotationAssertion(Annotation( "GO:0048103") "A stem cell that can give rise to cell types of the body other than those of the germ-line.") +AnnotationAssertion( "CALOHA:TS-2086") +AnnotationAssertion( "MESH:D053687") AnnotationAssertion(rdfs:label "somatic stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7181,6 +8912,10 @@ SubClassOf( ObjectSomeValuesFrom( (striated muscle cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "Muscle cell which has as its direct parts myofilaments organized into sarcomeres.") +AnnotationAssertion( "BTO:0002916") +AnnotationAssertion( "CALOHA:TS-2157") +AnnotationAssertion( "FMA:86936") AnnotationAssertion(rdfs:label "striated muscle cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7190,7 +8925,12 @@ DisjointClasses( (leukocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") Annotation( "ISBN:978-0-323-05290-0") "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.") +AnnotationAssertion( "BTO:0000751") +AnnotationAssertion( "CALOHA:TS-0549") +AnnotationAssertion( "FMA:62852") +AnnotationAssertion( "MESH:D007962") +AnnotationAssertion( "NCIT:C12529") AnnotationAssertion(rdfs:label "leukocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7205,14 +8945,22 @@ SubClassOf( ObjectSomeValuesFrom( (retinal ganglion cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:dph") "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.") +AnnotationAssertion( "BTO:0001800") +AnnotationAssertion( "FMA:67765") +AnnotationAssertion( "MESH:D012165") AnnotationAssertion(rdfs:label "retinal ganglion cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cardiac muscle cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:mtg_cardiacconduct_nov11") Annotation( "GOC:tfm") Annotation( "ISBN:0323052908") Annotation( "PMID:22426062") Annotation( "PMID:4711263") "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.") +AnnotationAssertion( "BTO:0001539") +AnnotationAssertion( "CALOHA:TS-0115") +AnnotationAssertion( "FMA:14067") +AnnotationAssertion( "MESH:D032383") +AnnotationAssertion(rdfs:comment "This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.") AnnotationAssertion(rdfs:label "cardiac muscle cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7223,6 +8971,10 @@ SubClassOf( ObjectSomeValuesFrom( (myeloid cell) +AnnotationAssertion(Annotation( "GOC:add") "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.") +AnnotationAssertion( "BTO:0001441") +AnnotationAssertion( "CALOHA:TS-0647") +AnnotationAssertion( "MESH:D022423") AnnotationAssertion(rdfs:label "myeloid cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7231,12 +8983,21 @@ SubClassOf( ObjectSomeValuesFrom( (erythroid lineage cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") "A immature or mature cell in the lineage leading to and including erythrocytes.") +AnnotationAssertion( "CALOHA:TS-0290") +AnnotationAssertion( "FMA:62845") +AnnotationAssertion( "FMA:83516") +AnnotationAssertion(rdfs:comment "Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes.") AnnotationAssertion(rdfs:label "erythroid lineage cell") SubClassOf( ) # Class: (erythroblast) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0721601464") Annotation( "PMID:18174176") "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.") +AnnotationAssertion( "BTO:0001571") +AnnotationAssertion( "CALOHA:TS-0289") +AnnotationAssertion( "FMA:83504") +AnnotationAssertion( "MESH:D004900") AnnotationAssertion(rdfs:label "erythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7259,6 +9020,7 @@ SubClassOf( ObjectSomeValuesFrom( (myeloid leukocyte) +AnnotationAssertion(Annotation( "GOC:add") "A cell of the monocyte, granulocyte, or mast cell lineage.") AnnotationAssertion(rdfs:label "myeloid leukocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7266,6 +9028,8 @@ SubClassOf( (mononuclear osteoclast) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") Annotation( "PMID:12713016") Annotation( "PMID:15055519") Annotation( "PMID:17380158") Annotation( "PMID:9415452") "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts.") +AnnotationAssertion(rdfs:comment "Morphology: mononuclear, highly vesicular.") AnnotationAssertion(rdfs:label "mononuclear osteoclast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7273,6 +9037,8 @@ SubClassOf( (multinuclear osteoclast) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:12713016") Annotation( "PMID:9415452") "A specialized multinuclear osteoclast associated with the absorption and removal of bone.") +AnnotationAssertion(rdfs:comment "Morphology: multinucleated, highly vesicular.") AnnotationAssertion(rdfs:label "multinuclear osteoclast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7281,6 +9047,9 @@ SubClassOf( ObjectSomeValuesFrom( (myeloid dendritic cell) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:10449155") Annotation( "PMID:17332250") Annotation( "PMID:9521319") "A dendritic cell of the myeloid lineage.") +AnnotationAssertion( "BTO:0004721") +AnnotationAssertion(rdfs:comment "These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).") AnnotationAssertion(rdfs:label "myeloid dendritic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7290,6 +9059,7 @@ SubClassOf( ObjectSomeValuesFrom( (multinucleated phagocyte) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") "A phagocyte formed by the fusion of mononuclear phagocytes.") AnnotationAssertion(rdfs:label "multinucleated phagocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7297,6 +9067,7 @@ SubClassOf( (pro-T cell) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage.") AnnotationAssertion(rdfs:label "pro-T cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7305,6 +9076,9 @@ SubClassOf( ObjectSomeValuesFrom( (myeloblast) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0721601464") Annotation( "http://en.wikipedia.org/wiki/Myeloblast") Annotation( "http://www.cap.org") "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow.") +AnnotationAssertion( "BTO:0000187") +AnnotationAssertion( "FMA:83524") AnnotationAssertion(rdfs:label "myeloblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7317,7 +9091,10 @@ SubClassOf( ObjectSomeValuesFrom( (hematopoietic multipotent progenitor cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") Annotation( "PMID:19022770") "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans.") +AnnotationAssertion( "BTO:0000725") +AnnotationAssertion( "CALOHA:TS-0448") +AnnotationAssertion(rdfs:comment "Markers differ between mouse and human.") AnnotationAssertion(rdfs:label "hematopoietic multipotent progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7342,6 +9119,11 @@ DisjointClasses( (lymphoid lineage restricted progenitor cell) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") "A progenitor cell restricted to the lymphoid lineage.") +AnnotationAssertion( "BTO:0004731") +AnnotationAssertion( "CALOHA:TS-2025") +AnnotationAssertion( "FMA:70338") +AnnotationAssertion(rdfs:comment "Note that this is a class of cell types, not an identified single cell type.") AnnotationAssertion(rdfs:label "lymphoid lineage restricted progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7351,7 +9133,11 @@ DisjointClasses( (myeloid lineage restricted progenitor cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") Annotation( "PMID:19022770") "A progenitor cell restricted to the myeloid lineage.") +AnnotationAssertion( "BTO:0004730") +AnnotationAssertion( "CALOHA:TS-2099") +AnnotationAssertion( "FMA:70339") +AnnotationAssertion(rdfs:comment "Note that this is a class of cell types, not an identified single cell type.") AnnotationAssertion(rdfs:label "myeloid lineage restricted progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7360,6 +9146,10 @@ SubClassOf( ObjectSomeValuesFrom( (mononuclear cell) +AnnotationAssertion(Annotation( "GOC:add") "A leukocyte with a single non-segmented nucleus in the mature form.") +AnnotationAssertion( "BTO:0000878") +AnnotationAssertion( "CALOHA:TS-0768") +AnnotationAssertion( "FMA:86713") AnnotationAssertion(rdfs:label "mononuclear cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7367,7 +9157,8 @@ SubClassOf( (classical monocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000031") Annotation( "PMID:16322748") Annotation( "PMID:18303997") Annotation( "PMID:20628149") Annotation( "PMID:20870168") "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes.") +AnnotationAssertion(rdfs:comment "Markers: CCR2+CXCCR1 (human, mouse, rat).") AnnotationAssertion(rdfs:label "classical monocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7380,6 +9171,10 @@ SubClassOf( ObjectSomeValuesFrom( (elicited macrophage) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:ana") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "PMID:15771589") "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive.") +AnnotationAssertion( "FMA:84643") +AnnotationAssertion( "FMA:84645") +AnnotationAssertion(rdfs:comment "Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response).") AnnotationAssertion(rdfs:label "elicited macrophage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7391,6 +9186,8 @@ SubClassOf( ObjectSomeValuesFrom( (suppressor macrophage) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:tfm") Annotation( "PMID:20402419") "A macrophage that suppresses immune responses.") +AnnotationAssertion(rdfs:comment "Markers: May express: IL10, TGFbeta.") AnnotationAssertion(rdfs:label "suppressor macrophage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7398,6 +9195,9 @@ SubClassOf( ObjectSomeValuesFrom( (tissue-resident macrophage) +AnnotationAssertion(Annotation( "GOC:ana") Annotation( "GO_REF:0000031") Annotation( "PMID:19770654") "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.") +AnnotationAssertion( "FMA:84642") +AnnotationAssertion( "FMA:84644") AnnotationAssertion(rdfs:label "tissue-resident macrophage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7405,6 +9205,7 @@ SubClassOf( ObjectSomeValuesFrom( (central nervous system macrophage) +AnnotationAssertion(Annotation( "GO_REF:0000031") Annotation( "PMID:16322748") "A tissue-resident macrophage found in the central nervous system.") AnnotationAssertion(rdfs:label "central nervous system macrophage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7413,7 +9214,8 @@ SubClassOf( ObjectSomeValuesFrom( (early lymphoid progenitor) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:dsd") Annotation( "GOC:pam") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "PMID:19022770") "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative.") +AnnotationAssertion(rdfs:comment "Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative.") AnnotationAssertion(rdfs:label "early lymphoid progenitor") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7427,12 +9229,19 @@ SubClassOf( ObjectSomeValuesFrom( (hematopoietic cell) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000031") "A cell of a hematopoietic lineage.") +AnnotationAssertion( "BTO:0000574") +AnnotationAssertion( "CALOHA:TS-2017") +AnnotationAssertion( "FMA:70366") +AnnotationAssertion( "FMA:83598") AnnotationAssertion(rdfs:label "hematopoietic cell") SubClassOf( ) # Class: (conventional dendritic cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:amm") Annotation( "GO_REF:0000031") Annotation( "PMID:17850486") "Conventional dendritic cell is a dendritic cell that is CD11c-high.") +AnnotationAssertion( "FMA:84191") +AnnotationAssertion(rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive.") AnnotationAssertion(rdfs:label "conventional dendritic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7440,12 +9249,15 @@ SubClassOf( ObjectSomeValuesFrom( (CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor) +AnnotationAssertion(rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617).") AnnotationAssertion(rdfs:label "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor") EquivalentClasses( ObjectUnionOf( )) SubClassOf( ) # Class: (Kit and Sca1-positive hematopoietic stem cell) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:amm") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "PMID:17952047") Annotation( "PMID:19022770") "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative.") +AnnotationAssertion(rdfs:comment "Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617).") AnnotationAssertion(rdfs:label "Kit and Sca1-positive hematopoietic stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7461,18 +9273,22 @@ DisjointClasses( (CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor) +AnnotationAssertion(rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617).") AnnotationAssertion(rdfs:label "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor") EquivalentClasses( ObjectUnionOf( )) SubClassOf( ) # Class: (CD115-positive monocyte OR common dendritic progenitor) +AnnotationAssertion(rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617).") AnnotationAssertion(rdfs:label "CD115-positive monocyte OR common dendritic progenitor") EquivalentClasses( ObjectUnionOf( )) SubClassOf( ) # Class: (CD34-positive, CD38-positive common lymphoid progenitor) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:amm") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "PMCID:PMC2346585") Annotation( "PMID:19022770") "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive.") +AnnotationAssertion(rdfs:comment "These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617).") AnnotationAssertion(rdfs:label "CD34-positive, CD38-positive common lymphoid progenitor") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7486,6 +9302,8 @@ DisjointClasses( (CD115-positive monocyte) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:amm") Annotation( "GO_REF:0000031") Annotation( "PMID:17952047") "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive.") +AnnotationAssertion(rdfs:comment "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617).") AnnotationAssertion(rdfs:label "CD115-positive monocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7497,6 +9315,8 @@ SubClassOf( ObjectSomeValuesFrom( (Kit-positive, CD34-positive common myeloid progenitor) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:amm") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "PMID:1261582") Annotation( "PMID:17952047") Annotation( "http://www.immgen.org/index_content.html") "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low.") +AnnotationAssertion(rdfs:comment "Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617).") AnnotationAssertion(rdfs:label "Kit-positive, CD34-positive common myeloid progenitor") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7511,6 +9331,9 @@ DisjointClasses( (CD34-positive, CD38-negative hematopoietic stem cell) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:amm") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "PMID:10430905") Annotation( "PMID:11750107") Annotation( "PMID:16551251") Annotation( "PMID:20024907") Annotation( "PMID:9389721") "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive.") +AnnotationAssertion( "CALOHA:TS-0448") +AnnotationAssertion(rdfs:comment "Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617).") AnnotationAssertion(rdfs:label "CD34-positive, CD38-negative hematopoietic stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7525,6 +9348,8 @@ SubClassOf( ObjectSomeValuesFrom( (Kit-positive, Sca1-positive common lymphoid progenitor) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:amm") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "PMID:17952047") Annotation( "http://www.immgen.org/index_content.html") "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low.") +AnnotationAssertion(rdfs:comment "Markers are associated with mouse cells.") AnnotationAssertion(rdfs:label "Kit-positive, Sca1-positive common lymphoid progenitor") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7540,6 +9365,8 @@ SubClassOf( ObjectSomeValuesFrom( (CD34-positive, CD38-positive common myeloid progenitor) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:amm") Annotation( "GO_REF:0000031") Annotation( "PMCID:PMC2626675") Annotation( "PMID:16551251") "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative.") +AnnotationAssertion(rdfs:comment "Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617).") AnnotationAssertion(rdfs:label "CD34-positive, CD38-positive common myeloid progenitor") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7554,6 +9381,8 @@ SubClassOf( ObjectSomeValuesFrom( (CD7-negative lymphoid progenitor cell) +AnnotationAssertion(Annotation( "GOC:amm") Annotation( "GO_REF:0000031") Annotation( "PMID:16551251") "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative.") +AnnotationAssertion(rdfs:comment "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617).") AnnotationAssertion(rdfs:label "CD7-negative lymphoid progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7565,6 +9394,8 @@ SubClassOf( ObjectSomeValuesFrom( (CD7-positive lymphoid progenitor cell) +AnnotationAssertion(Annotation( "GOC:amm") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "PMID:16551251") Annotation( "PMID:19491395") "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative.") +AnnotationAssertion(rdfs:comment "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617).") AnnotationAssertion(rdfs:label "CD7-positive lymphoid progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7575,6 +9406,8 @@ SubClassOf( ObjectSomeValuesFrom( (common dendritic progenitor) +AnnotationAssertion(Annotation( "GOC:amm") Annotation( "GOC:tfm") Annotation( "GO_REF:0000031") Annotation( "PMID:16551251") Annotation( "PMID:17922016") Annotation( "PMID:19286519") "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers.") +AnnotationAssertion(rdfs:comment "Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617).") AnnotationAssertion(rdfs:label "common dendritic progenitor") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7598,13 +9431,14 @@ SubClassOf( ObjectSomeValuesFrom( (CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor) +AnnotationAssertion(rdfs:comment "Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617).") AnnotationAssertion(rdfs:label "CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor") EquivalentClasses( ObjectUnionOf( )) SubClassOf( ) # Class: (bone cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000034") "A connective tissue cell found in bone.") AnnotationAssertion(rdfs:label "bone cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7612,7 +9446,8 @@ SubClassOf( ObjectSomeValuesFrom( (CD14-positive monocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:22343568") "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20.") +AnnotationAssertion(rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes.") AnnotationAssertion(rdfs:label "CD14-positive monocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7623,6 +9458,8 @@ SubClassOf( ObjectSomeValuesFrom( (common myeloid progenitor, CD34-positive) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:dsd") Annotation( "GOC:tfm") Annotation( "ISBN:0878932437") Annotation( "PMCID:PMC2212039") Annotation( "PMID:10724173") Annotation( "PMID:16551251") Annotation( "PMID:16647566") "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1.") +AnnotationAssertion(rdfs:comment "CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.") AnnotationAssertion(rdfs:label "common myeloid progenitor, CD34-positive") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7636,6 +9473,7 @@ SubClassOf( ObjectSomeValuesFrom( (hematopoietic oligopotent progenitor cell, lineage-negative) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:19022770") "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers.") AnnotationAssertion(rdfs:label "hematopoietic oligopotent progenitor cell, lineage-negative") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7654,6 +9492,8 @@ SubClassOf( ObjectSomeValuesFrom( (erythroid progenitor cell, mammalian) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0721601464") "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative).") +AnnotationAssertion( "BTO:0004911") AnnotationAssertion(rdfs:label "erythroid progenitor cell, mammalian") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7673,6 +9513,8 @@ SubClassOf( ObjectSomeValuesFrom( (Kit-positive erythroid progenitor cell) +AnnotationAssertion(Annotation( "GOC:ak") Annotation( "GOC:tfm") Annotation( "PMID:19805084") Annotation( "http://www.immgen.org/index_content.html") "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative.") +AnnotationAssertion(rdfs:comment "Markers found on mouse cells.") AnnotationAssertion(rdfs:label "Kit-positive erythroid progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7688,6 +9530,8 @@ SubClassOf( ObjectSomeValuesFrom( (CD34-positive, CD38-positive granulocyte monocyte progenitor) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:12615892") Annotation( "PMID:19022770") "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative.") +AnnotationAssertion(rdfs:comment "Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population.") AnnotationAssertion(rdfs:label "CD34-positive, CD38-positive granulocyte monocyte progenitor") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7697,6 +9541,8 @@ SubClassOf( ObjectSomeValuesFrom( (Kit-positive granulocyte monocyte progenitor) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:12615892") Annotation( "PMID:16322423") Annotation( "PMID:19022770") Annotation( "PMID:19273628") Annotation( "http://www.immgen.org/index_content.html") "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative.") +AnnotationAssertion(rdfs:comment "Markers are found on mouse cells.") AnnotationAssertion(rdfs:label "Kit-positive granulocyte monocyte progenitor") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7712,6 +9558,9 @@ SubClassOf( ObjectSomeValuesFrom( (CD34-positive, GlyA-negative erythroid progenitor cell) +AnnotationAssertion(Annotation( "GOC:ak") Annotation( "GOC:tfm") Annotation( "PMID:19621348") "An erythroid progenitor cell that is CD34-positive and is GlyA-negative.") +AnnotationAssertion( "FMA:83517") +AnnotationAssertion(rdfs:comment "Cell markers associated with human cells.") AnnotationAssertion(rdfs:label "CD34-positive, GlyA-negative erythroid progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7721,6 +9570,8 @@ SubClassOf( ObjectSomeValuesFrom( (CD34-negative, GlyA-negative proerythroblast) +AnnotationAssertion(Annotation( "GOC:ak") Annotation( "GOC:tfm") Annotation( "PMID:19621348") "A proerythoblast that is CD34-negative and GlyA-negative.") +AnnotationAssertion(rdfs:comment "Cell surface markers are associated with human cells.") AnnotationAssertion(rdfs:label "CD34-negative, GlyA-negative proerythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7730,6 +9581,8 @@ SubClassOf( ObjectSomeValuesFrom( (CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:12615892") Annotation( "PMID:190227700") "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative.") +AnnotationAssertion(rdfs:comment "Markers are associated with human cell type.") AnnotationAssertion(rdfs:label "CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7740,6 +9593,8 @@ SubClassOf( ObjectSomeValuesFrom( (Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:12615892") Annotation( "PMID:19022770") Annotation( "http://www.immgen.org/index_content.html") "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low.") +AnnotationAssertion(rdfs:comment "Markers are associated with mouse cells.") AnnotationAssertion(rdfs:label "Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7753,6 +9608,7 @@ SubClassOf( ObjectSomeValuesFrom( (macrophage dendritic cell progenitor) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:19273628") "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages.") AnnotationAssertion(rdfs:label "macrophage dendritic cell progenitor") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7764,6 +9620,7 @@ SubClassOf( ObjectSomeValuesFrom( (pre-conventional dendritic cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha.") AnnotationAssertion(rdfs:label "pre-conventional dendritic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7788,6 +9645,8 @@ SubClassOf( ObjectSomeValuesFrom( (Kit-positive macrophage dendritic cell progenitor) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:19273628") "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative.") +AnnotationAssertion(rdfs:comment "Markers are associated with mouse cells.") AnnotationAssertion(rdfs:label "Kit-positive macrophage dendritic cell progenitor") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7799,6 +9658,8 @@ SubClassOf( ObjectSomeValuesFrom( (Kit-low proerythroblast) +AnnotationAssertion(Annotation( "GOC:ak") Annotation( "GOC:tfm") Annotation( "PMID:19805084") "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive.") +AnnotationAssertion(rdfs:comment "Markers are associated with mouse cells.") AnnotationAssertion(rdfs:label "Kit-low proerythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7811,6 +9672,8 @@ SubClassOf( ObjectSomeValuesFrom( (GlyA-positive basophilic erythroblast) +AnnotationAssertion(Annotation( "GOC:ak") Annotation( "GOC:tfm") Annotation( "PMID:1638021") "A basophilic erythroblast that is GlyA-positive.") +AnnotationAssertion(rdfs:comment "Markers are associated with human cells.") AnnotationAssertion(rdfs:label "GlyA-positive basophilic erythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7820,6 +9683,8 @@ SubClassOf( ObjectSomeValuesFrom( (Kit-negative, Ly-76 high basophilic erythroblast) +AnnotationAssertion(Annotation( "GOC:ak") Annotation( "GOC:tfm") Annotation( "PMID:19805084") "A basophilic erythroblast that is Lyg 76-high and is Kit-negative.") +AnnotationAssertion(rdfs:comment "Cell surface markers are associated with mouse cells.") AnnotationAssertion(rdfs:label "Kit-negative, Ly-76 high basophilic erythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7831,6 +9696,7 @@ SubClassOf( ObjectSomeValuesFrom( (Kit-negative, Ly-76 high polychromatophilic erythroblast) +AnnotationAssertion(Annotation( "GOC:ak") Annotation( "GOC:tfm") Annotation( "PMID:19805084") "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative.") AnnotationAssertion(rdfs:label "Kit-negative, Ly-76 high polychromatophilic erythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7842,6 +9708,8 @@ SubClassOf( ObjectSomeValuesFrom( (CD71-low, GlyA-positive polychromatic erythroblast) +AnnotationAssertion(Annotation( "GOC:ak") Annotation( "GOC:tfm") Annotation( "PMID:1638021") "A polychromatiic erythroblast that is Gly-A-positive and CD71-low.") +AnnotationAssertion(rdfs:comment "Cell surface markers are associated with human cells.") AnnotationAssertion(rdfs:label "CD71-low, GlyA-positive polychromatic erythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7851,6 +9719,8 @@ SubClassOf( ObjectSomeValuesFrom( (Kit-negative, Ly-76 high orthochromatophilic erythroblasts) +AnnotationAssertion(Annotation( "GOC:ak") Annotation( "GOC:tfm") Annotation( "PMID:19805084") "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative.") +AnnotationAssertion(rdfs:comment "Cell surface markers associated with mouse cells.") AnnotationAssertion(rdfs:label "Kit-negative, Ly-76 high orthochromatophilic erythroblasts") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7863,6 +9733,8 @@ SubClassOf( ObjectSomeValuesFrom( (CD71-negative, GlyA-positive orthochromatic erythroblast) +AnnotationAssertion(Annotation( "GOC:ak") Annotation( "GOC:tfm") Annotation( "PMID:1638021") "An erythroblast that is GlyA-positive and CD71-negative.") +AnnotationAssertion(rdfs:comment "Markers associated with human cells.") AnnotationAssertion(rdfs:label "CD71-negative, GlyA-positive orthochromatic erythroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7872,6 +9744,7 @@ SubClassOf( ObjectSomeValuesFrom( (hematopoietic lineage restricted progenitor cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:19022770") "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells.") AnnotationAssertion(rdfs:label "hematopoietic lineage restricted progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7882,6 +9755,8 @@ DisjointClasses( (hematopoietic oligopotent progenitor cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:19022770") Annotation( "https://orcid.org/0000-0001-5208-3432") "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities.") +AnnotationAssertion(rdfs:comment "This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).") AnnotationAssertion(rdfs:label "hematopoietic oligopotent progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7891,6 +9766,8 @@ SubClassOf( ObjectSomeValuesFrom( (short term hematopoietic stem cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:15572596") Annotation( "PMID:19022770") "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative.") +AnnotationAssertion(rdfs:comment "Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low.") AnnotationAssertion(rdfs:label "short term hematopoietic stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7900,6 +9777,8 @@ SubClassOf( ObjectSomeValuesFrom( (long term hematopoietic stem cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:15572596") Annotation( "PMID:17582345") "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative.") +AnnotationAssertion(rdfs:comment "Markers are associated with mouse cells.") AnnotationAssertion(rdfs:label "long term hematopoietic stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7909,6 +9788,8 @@ SubClassOf( ObjectSomeValuesFrom( (Slamf1-negative multipotent progenitor cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:19022770") "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative.") +AnnotationAssertion(rdfs:comment "Markers are associated with mouse cells.") AnnotationAssertion(rdfs:label "Slamf1-negative multipotent progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7920,6 +9801,8 @@ SubClassOf( ObjectSomeValuesFrom( (Slamf1-positive multipotent progenitor cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:19022770") "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive.") +AnnotationAssertion(rdfs:comment "Markers are associated with mouse cells.") AnnotationAssertion(rdfs:label "Slamf1-positive multipotent progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7931,6 +9814,8 @@ DisjointClasses( (CD34-positive, CD38-negative multipotent progenitor cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:18371405") Annotation( "PMID:19022770") "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative.") +AnnotationAssertion(rdfs:comment "Cell markers are associated with human hematopoietic multipotent progenitor cells.") AnnotationAssertion(rdfs:label "CD34-positive, CD38-negative multipotent progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7941,7 +9826,9 @@ SubClassOf( ObjectSomeValuesFrom( (pulmonary alveolar type 1 cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:20054144") Annotation( "PMID:29463737") Annotation( "http://www.copewithcytokines.de") "A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange.") +AnnotationAssertion( "BTO:0000780") +AnnotationAssertion( "FMA:62500") AnnotationAssertion(rdfs:label "pulmonary alveolar type 1 cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7949,7 +9836,9 @@ SubClassOf( ObjectSomeValuesFrom( (pulmonary alveolar type 2 cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0412046911") Annotation( "PMID:36138472") Annotation( "PMID:8540632") Annotation( "http://www.copewithcytokines.de") "A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli.") +AnnotationAssertion( "BTO:0000538") +AnnotationAssertion( "FMA:62501") AnnotationAssertion(rdfs:label "pulmonary alveolar type 2 cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7957,8 +9846,23 @@ SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreatic acinar cell) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0517223651") Annotation( "PMID:20395539") Annotation( "http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells") "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.") +AnnotationAssertion( "BTO:0000028") +AnnotationAssertion( "CALOHA:TS-0737") +AnnotationAssertion( "FMA:63032") +AnnotationAssertion(rdfs:label "pancreatic acinar cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (type A enteroendocrine cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0412046911") "An enteroendocrine cell that produces glucagon.") +AnnotationAssertion( "FMA:62939") AnnotationAssertion(rdfs:label "type A enteroendocrine cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7966,28 +9870,39 @@ SubClassOf( (Purkinje myocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FMA:0412046911") Annotation( "GOC:tfm") Annotation( "PMID:19939742") "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter.") +AnnotationAssertion( "BTO:0001032") +AnnotationAssertion( "FMA:14146") AnnotationAssertion(rdfs:label "Purkinje myocyte") SubClassOf( ) # Class: (nodal myocyte) +AnnotationAssertion(Annotation( "FMA:67101") Annotation( "GOC:tfm") "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery.") +AnnotationAssertion( "BTO:0004190") +AnnotationAssertion( "FMA:67101") AnnotationAssertion(rdfs:label "nodal myocyte") SubClassOf( ) # Class: (transitional myocyte) +AnnotationAssertion(Annotation( "FMA:67142") Annotation( "GOC:tfm") "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes.") +AnnotationAssertion( "FMA:67142") AnnotationAssertion(rdfs:label "transitional myocyte") SubClassOf( ) # Class: (myocardial endocrine cell) +AnnotationAssertion(Annotation( "FMA:67111") Annotation( "GOC:tfm") "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides).") +AnnotationAssertion( "FMA:67111") AnnotationAssertion(rdfs:label "myocardial endocrine cell") SubClassOf( ) SubClassOf( ) # Class: (endo-epithelial cell) +AnnotationAssertion(Annotation( "FMA:69075") Annotation( "GOC:tfm") "An epithelial cell derived from endoderm.") +AnnotationAssertion( "FMA:69075") AnnotationAssertion(rdfs:label "endo-epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -7996,6 +9911,8 @@ SubClassOf( ObjectSomeValuesFrom( (ecto-epithelial cell) +AnnotationAssertion(Annotation( "FMA:69074") Annotation( "GOC:tfm") "An epithelial cell derived from ectoderm.") +AnnotationAssertion( "FMA:69074") AnnotationAssertion(rdfs:label "ecto-epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8004,26 +9921,69 @@ SubClassOf( ObjectSomeValuesFrom( (meso-epithelial cell) +AnnotationAssertion(Annotation( "FMA:69076") Annotation( "GOC:tfm") "Epithelial cell derived from mesoderm or mesenchyme.") +AnnotationAssertion( "FMA:69076") AnnotationAssertion(rdfs:label "meso-epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreatic ductal cell) + +AnnotationAssertion(Annotation( "FMA:63099") Annotation( "GOC:tfm") Annotation( "PMID:14740223") "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH.") +AnnotationAssertion( "FMA:63099") +AnnotationAssertion(rdfs:label "pancreatic ductal cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreatic centro-acinar cell) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:12142741") Annotation( "PMID:20018761") Annotation( "PMID:8185160") "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types.") +AnnotationAssertion( "FMA:62455") +AnnotationAssertion(rdfs:label "pancreatic centro-acinar cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (specialized cardiac myocyte) +AnnotationAssertion(Annotation( "FMA:67968") Annotation( "GOC:tfm") "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart.") +AnnotationAssertion( "FMA:67968") AnnotationAssertion(rdfs:label "specialized cardiac myocyte") SubClassOf( ) # Class: (nongranular leukocyte) +AnnotationAssertion(Annotation( "GOC:tfm") "A leukocyte that lacks granules.") +AnnotationAssertion( "FMA:62855") AnnotationAssertion(rdfs:label "nongranular leukocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (interstitial cell of Cajal) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:16460275") Annotation( "PMID:19520112") "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise.") +AnnotationAssertion( "BTO:0003914") +AnnotationAssertion( "FMA:86573") +AnnotationAssertion(rdfs:comment "Some argue this cell type is of mesenchymal origin.") +AnnotationAssertion(rdfs:label "interstitial cell of Cajal") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (bone marrow cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0618947256") "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells.") +AnnotationAssertion( "BTO:0004850") +AnnotationAssertion( "FMA:83621") +AnnotationAssertion( "MESH:D001854") +AnnotationAssertion(rdfs:comment "MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense.") AnnotationAssertion(rdfs:label "bone marrow cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8031,13 +9991,16 @@ SubClassOf( ObjectSomeValuesFrom( (hilus cell of ovary) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:068340007X") "A cell in the hilum of the ovary that produces androgens.") +AnnotationAssertion( "FMA:18710") AnnotationAssertion(rdfs:label "hilus cell of ovary") SubClassOf( ) SubClassOf( ) # Class: (stromal cell of ovary) +AnnotationAssertion(Annotation( "GOC:tfm") "A stomal cell of the ovary") +AnnotationAssertion( "FMA:72299") AnnotationAssertion(rdfs:label "stromal cell of ovary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8045,12 +10008,20 @@ SubClassOf( ObjectSomeValuesFrom( (endothelial cell of vascular tree) +AnnotationAssertion(Annotation( "GOC:dsd") Annotation( "GOC:tfm") Annotation( "PMID:12768659") "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.") +AnnotationAssertion( "BTO:0001854") +AnnotationAssertion( "CALOHA:TS-1106") +AnnotationAssertion( "FMA:67755") +AnnotationAssertion(rdfs:comment "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive.") AnnotationAssertion(rdfs:label "endothelial cell of vascular tree") SubClassOf( ) # Class: (capillary endothelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "An endothelial cell found in capillaries.") +AnnotationAssertion( "BTO:0004956") +AnnotationAssertion( "CALOHA:TS-0112") +AnnotationAssertion( "FMA:67756") AnnotationAssertion(rdfs:label "capillary endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8059,7 +10030,8 @@ SubClassOf( ObjectSomeValuesFrom( (ciliated columnar cell of tracheobronchial tree) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0517223651") "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree.") +AnnotationAssertion( "FMA:70542") AnnotationAssertion(rdfs:label "ciliated columnar cell of tracheobronchial tree") SubClassOf( ) SubClassOf( ) @@ -8068,11 +10040,15 @@ SubClassOf( ObjectSomeValuesFrom( (general ecto-epithelial cell) +AnnotationAssertion(Annotation( "GOC:tfm") "Epithelial cells derived from general body ectoderm and ectoderm placodes.") +AnnotationAssertion( "FMA:70556") AnnotationAssertion(rdfs:label "general ecto-epithelial cell") SubClassOf( ) # Class: (epithelial cell of stomach) +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell found in the lining of the stomach.") +AnnotationAssertion( "FMA:62948") AnnotationAssertion(rdfs:label "epithelial cell of stomach") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8080,6 +10056,8 @@ SubClassOf( ObjectSomeValuesFrom( (mucous cell of stomach) +AnnotationAssertion(Annotation( "GOC:tfm") "A mucous cell in the epithelium of the stomach.") +AnnotationAssertion( "FMA:63464") AnnotationAssertion(rdfs:label "mucous cell of stomach") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8087,6 +10065,8 @@ SubClassOf( ObjectSomeValuesFrom( (stem cell of gastric gland) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0517223651") "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit.") +AnnotationAssertion( "FMA:62953") AnnotationAssertion(rdfs:label "stem cell of gastric gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8096,6 +10076,8 @@ SubClassOf( ObjectSomeValuesFrom( (granulocytopoietic cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A cell involved in the formation of a granulocyte.") +AnnotationAssertion( "FMA:83519") AnnotationAssertion(rdfs:label "granulocytopoietic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8103,13 +10085,26 @@ SubClassOf( ObjectSomeValuesFrom( (monopoietic cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A cell involved in the formation of a monocyte (monopoiesis).") +AnnotationAssertion( "FMA:83552") AnnotationAssertion(rdfs:label "monopoietic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepatic stem cell) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:26798363") "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes).") +AnnotationAssertion( "FMA:86577") +AnnotationAssertion(rdfs:label "hepatic stem cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (epithelial cell of tracheobronchial tree) +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell of the tracheobronchial tree.") +AnnotationAssertion( "FMA:66816") AnnotationAssertion(rdfs:label "epithelial cell of tracheobronchial tree") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8117,11 +10112,15 @@ SubClassOf( ObjectSomeValuesFrom( (intermediate epitheliocyte) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0517223651") "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells.") +AnnotationAssertion( "FMA:69060") AnnotationAssertion(rdfs:label "intermediate epitheliocyte") SubClassOf( ) # Class: (vertebrate lens cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye.") +AnnotationAssertion( "FMA:70950") AnnotationAssertion(rdfs:label "vertebrate lens cell") SubClassOf( ) SubClassOf( ) @@ -8129,7 +10128,8 @@ SubClassOf( ObjectSomeValuesFrom( (lens epithelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") Annotation( "http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium") "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth.") +AnnotationAssertion( "FMA:67559") AnnotationAssertion(rdfs:label "lens epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8138,6 +10138,8 @@ SubClassOf( ObjectSomeValuesFrom( (marrow fibroblast) +AnnotationAssertion(Annotation( "GOC:tfm") "A fibroblast in the bone marrow.") +AnnotationAssertion( "FMA:84377") AnnotationAssertion(rdfs:label "marrow fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8145,6 +10147,8 @@ SubClassOf( (pulmonary interstitial fibroblast) +AnnotationAssertion(Annotation( "GOC:tfm") "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis.") +AnnotationAssertion( "FMA:84467") AnnotationAssertion(rdfs:label "pulmonary interstitial fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8153,13 +10157,29 @@ SubClassOf( ObjectSomeValuesFrom( (nucleate cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A cell containing at least one nucleus.") +AnnotationAssertion( "FMA:67513") AnnotationAssertion(rdfs:label "nucleate cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (smooth muscle cell of sphincter of pupil) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") Annotation( "ISBN:0721694128") "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells.") +AnnotationAssertion( "FMA:70611") +AnnotationAssertion(rdfs:label "smooth muscle cell of sphincter of pupil") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (peripheral blood stem cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells).") +AnnotationAssertion( "BTO:0002669") +AnnotationAssertion( "FMA:86711") +AnnotationAssertion( "MESH:D000072916") AnnotationAssertion(rdfs:label "peripheral blood stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8168,6 +10188,7 @@ SubClassOf( ObjectSomeValuesFrom( (epithelial cell of alimentary canal) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0721662544") "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus.") AnnotationAssertion(rdfs:label "epithelial cell of alimentary canal") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8175,14 +10196,36 @@ SubClassOf( ObjectSomeValuesFrom( (epithelial cell of esophagus) +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell of the esophagus.") +AnnotationAssertion( "FMA:63071") AnnotationAssertion(rdfs:label "epithelial cell of esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelial cell of large intestine) + +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell of the large intestine.") +AnnotationAssertion( "BTO:0004297") +AnnotationAssertion( "FMA:256157") +AnnotationAssertion(rdfs:label "epithelial cell of large intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (epithelial cell of small intestine) + +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell of the small intestine.") +AnnotationAssertion( "FMA:256159") +AnnotationAssertion(rdfs:label "epithelial cell of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (endothelial cell of sinusoid) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0618947256") "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver.") +AnnotationAssertion( "FMA:63134") AnnotationAssertion(rdfs:label "endothelial cell of sinusoid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8190,13 +10233,57 @@ SubClassOf( ObjectSomeValuesFrom( (type A cell of stomach) +AnnotationAssertion(Annotation( "GOC:tfm") "A type of enteroendocrine cell found in the stomach that secretes glucagon.") +AnnotationAssertion( "FMA:83411") AnnotationAssertion(rdfs:label "type A cell of stomach") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (type D cell of colon) + +AnnotationAssertion(Annotation( "GOC:tfm") "A D cell located in the colon.") +AnnotationAssertion( "FMA:268744") +AnnotationAssertion(rdfs:label "type D cell of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (type D cell of small intestine) + +AnnotationAssertion(Annotation( "GOC:tfm") "A type D cell of the small intestine.") +AnnotationAssertion( "FMA:268736") +AnnotationAssertion(rdfs:label "type D cell of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (type D cell of stomach) + +AnnotationAssertion(Annotation( "GOC:tfm") "A type D cell found in the stomach.") +AnnotationAssertion( "FMA:83410") +AnnotationAssertion(rdfs:label "type D cell of stomach") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (pancreatic PP cell) + +AnnotationAssertion(Annotation( "GOC:tfm") "A PP cell located in the islets of the pancreas.") +AnnotationAssertion( "BTO:0000805") +AnnotationAssertion( "FMA:70588") +AnnotationAssertion( "MESH:D050418") +AnnotationAssertion(rdfs:comment "The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell.") +AnnotationAssertion(rdfs:label "pancreatic PP cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (epithelial cell of skin gland) +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell of a skin gland.") +AnnotationAssertion( "FMA:70657") AnnotationAssertion(rdfs:label "epithelial cell of skin gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8204,6 +10291,9 @@ SubClassOf( ObjectSomeValuesFrom( (neural cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0618947256") "A cell that is part of the nervous system.") +AnnotationAssertion( "CALOHA:TS-2040") +AnnotationAssertion( "FMA:70333") AnnotationAssertion(rdfs:label "neural cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8211,6 +10301,10 @@ SubClassOf( ObjectSomeValuesFrom( (connective tissue cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0618947256") "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.") +AnnotationAssertion( "CALOHA:TS-2096") +AnnotationAssertion( "FMA:63875") +AnnotationAssertion( "MESH:D003239") AnnotationAssertion(rdfs:label "connective tissue cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8218,11 +10312,17 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic cell (metazoa)) +AnnotationAssertion(Annotation( "FMA:0618947256") "A cell of the embryo.") +AnnotationAssertion( "CALOHA:TS-0263") +AnnotationAssertion( "FMA:82840") +AnnotationAssertion( "WBbt:0007028") AnnotationAssertion(rdfs:label "embryonic cell (metazoa)") SubClassOf( ) # Class: (bronchial epithelial cell) +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell of the bronchus.") +AnnotationAssertion( "BTO:0002922") AnnotationAssertion(rdfs:label "bronchial epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8230,7 +10330,7 @@ SubClassOf( ObjectSomeValuesFrom( (ciliated cell of the bronchus) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:18757316") "A ciliated cell of the bronchus.") AnnotationAssertion(rdfs:label "ciliated cell of the bronchus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8238,6 +10338,7 @@ SubClassOf( (neural crest derived adipocyte) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:17507398") "An adipocyte derived from a neural crest cell.") AnnotationAssertion(rdfs:label "neural crest derived adipocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8245,14 +10346,22 @@ SubClassOf( ObjectSomeValuesFrom( (endocardial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISSN:0452-3458") "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin.") +AnnotationAssertion( "FMA:75621") AnnotationAssertion(rdfs:label "endocardial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (progenitor cell of endocrine pancreas) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:20025937") Annotation( "PMID:20217494") Annotation( "PMID:22728667") "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1.") +AnnotationAssertion(rdfs:label "progenitor cell of endocrine pancreas") +SubClassOf( ) + # Class: (gestational hematopoietic stem cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:978-60327-246-6") "A hematopoietic stem cell that exists during embryogenesis.") AnnotationAssertion(rdfs:label "gestational hematopoietic stem cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8260,7 +10369,7 @@ SubClassOf( ObjectSomeValuesFrom( (keratocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:9780702029585") "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate.") AnnotationAssertion(rdfs:label "keratocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8268,6 +10377,8 @@ SubClassOf( ObjectSomeValuesFrom( (respiratory epithelial cell) +AnnotationAssertion(Annotation( "GOC:tfm") "An endo-epithelial cell of the respiratory tract.") +AnnotationAssertion( "BTO:0004533") AnnotationAssertion(rdfs:label "respiratory epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8275,6 +10386,7 @@ SubClassOf( ObjectSomeValuesFrom( (myotube) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:tfm") Annotation( "ISBN:0323052908") Annotation( "PMID:22274696") "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts.") AnnotationAssertion(rdfs:label "myotube") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8283,6 +10395,8 @@ SubClassOf( ObjectSomeValuesFrom( (CD14-positive, CD16-positive monocyte) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:20628149") Annotation( "PMID:21937707") Annotation( "PMID:22343568") "A CD14-positive monocyte that is also CD16-positive and CCR2-negative.") +AnnotationAssertion(rdfs:comment "This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+).") AnnotationAssertion(rdfs:label "CD14-positive, CD16-positive monocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8291,6 +10405,7 @@ SubClassOf( ObjectSomeValuesFrom( (nucleated reticulocyte) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:18182572") Annotation( "PMID:9011180") Annotation( "PMID:9046052") "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles.") AnnotationAssertion(rdfs:label "nucleated reticulocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8298,6 +10413,7 @@ SubClassOf( (Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "http://www.immgen.org/index_content.html") "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive.") AnnotationAssertion(rdfs:label "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8306,6 +10422,7 @@ SubClassOf( ObjectSomeValuesFrom( (adipose dendritic cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "http://www.immgen.org/index_content.html") "A F4/80-negative dendritic cell located in adipose tissue.") AnnotationAssertion(rdfs:label "adipose dendritic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8317,6 +10434,7 @@ SubClassOf( ObjectSomeValuesFrom( (SIRPa-positive adipose dendritic cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "http://www.immgen.org/index_content.html") "An adipose dendritic cell that is SIRPa-positive.") AnnotationAssertion(rdfs:label "SIRPa-positive adipose dendritic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8324,6 +10442,7 @@ SubClassOf( ObjectSomeValuesFrom( (SIRPa-negative adipose dendritic cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "http://www.immgen.org/index_content.html") "An adipose dendritic cell that is SIRPa-negative.") AnnotationAssertion(rdfs:label "SIRPa-negative adipose dendritic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8331,6 +10450,7 @@ SubClassOf( ObjectSomeValuesFrom( (CD11b-positive dendritic cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "http://www.immgen.org/index_content.html") "A conventional dendritic cell that expresses CD11b (ITGAM).") AnnotationAssertion(rdfs:label "CD11b-positive dendritic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8338,6 +10458,12 @@ SubClassOf( ObjectSomeValuesFrom( (cardiocyte) +AnnotationAssertion(Annotation( "GOC:tfm") "A cell located in the heart, including both muscle and non muscle cells.") +AnnotationAssertion( "BTO:0001539") +AnnotationAssertion( "CALOHA:TS-0115") +AnnotationAssertion( "FMA:83808") +AnnotationAssertion( "FMA:84791") +AnnotationAssertion(rdfs:comment "From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart.") AnnotationAssertion(rdfs:label "cardiocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8345,22 +10471,43 @@ SubClassOf( ObjectSomeValuesFrom( (adventitial cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc") +AnnotationAssertion( "BTO:0002441") +AnnotationAssertion( "FMA:84639") AnnotationAssertion(rdfs:label "adventitial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (enteric smooth muscle cell) + +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell of the intestine.") +AnnotationAssertion(rdfs:label "enteric smooth muscle cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (subcutaneous adipocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "An adipocyte that is part of subcutaneous adipose tissue.") AnnotationAssertion(rdfs:label "subcutaneous adipocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (intrahepatic cholangiocyte) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:23720296") "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes.") +AnnotationAssertion(rdfs:label "intrahepatic cholangiocyte") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (aortic smooth muscle cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell of the aorta.") +AnnotationAssertion( "BTO:0004577") AnnotationAssertion(rdfs:label "aortic smooth muscle cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8368,6 +10515,7 @@ SubClassOf( ObjectSomeValuesFrom( (mesenchymal stem cell of the bone marrow) +AnnotationAssertion(Annotation( "GOC:tfm") "A mesenchymal stem cell that is part of the bone marrow.") AnnotationAssertion(rdfs:label "mesenchymal stem cell of the bone marrow") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8375,7 +10523,9 @@ SubClassOf( (vein endothelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "An endothelial cell that is part of the vein.") +AnnotationAssertion( "FMA:62104") +AnnotationAssertion( "KUPO:0001099") AnnotationAssertion(rdfs:label "vein endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8383,11 +10533,14 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic blood vessel endothelial progenitor cell) +AnnotationAssertion(Annotation( "GOC:tfm") "An endothelial progenitor cell that participates in angiogenesis during development.") +AnnotationAssertion(rdfs:comment "See CL:0002619.") AnnotationAssertion(rdfs:label "embryonic blood vessel endothelial progenitor cell") SubClassOf( ) # Class: (fibroblast of the aortic adventitia) +AnnotationAssertion(Annotation( "GOC:tfm") "A fibroblast of the aortic adventitia.") AnnotationAssertion(rdfs:label "fibroblast of the aortic adventitia") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8395,6 +10548,7 @@ SubClassOf( ObjectSomeValuesFrom( (fibroblast of cardiac tissue) +AnnotationAssertion(Annotation( "GOC:tfm") "A fibroblast that is part of the heart.") AnnotationAssertion(rdfs:label "fibroblast of cardiac tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8403,6 +10557,7 @@ SubClassOf( ObjectSomeValuesFrom( (fibroblast of dermis) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any skin fibroblast that is part of some dermis.") AnnotationAssertion(rdfs:label "fibroblast of dermis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8410,6 +10565,9 @@ SubClassOf( ObjectSomeValuesFrom( (fibroblast of lung) +AnnotationAssertion(Annotation( "GOC:tfm") "A fibroblast that is part of lung.") +AnnotationAssertion( "BTO:0000764") +AnnotationAssertion( "CALOHA:TS-0575") AnnotationAssertion(rdfs:label "fibroblast of lung") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8417,21 +10575,56 @@ SubClassOf( ObjectSomeValuesFrom( (fibroblast of pulmonary artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "A fibroblast of pulmonary artery.") AnnotationAssertion(rdfs:label "fibroblast of pulmonary artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (intestinal epithelial cell) + +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell of the intestine.") +AnnotationAssertion(rdfs:label "intestinal epithelial cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mesenchymal stem cell of adipose tissue) +AnnotationAssertion(Annotation( "GOC:tfm") "A mesenchymal stem cell of adipose tissue.") AnnotationAssertion(rdfs:label "mesenchymal stem cell of adipose tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepatic mesenchymal stem cell) + +AnnotationAssertion(Annotation( "GOC:tfm") "A mesenchymal stem cell of liver.") +AnnotationAssertion(rdfs:label "hepatic mesenchymal stem cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (vertebral mesenchymal stem cell) + +AnnotationAssertion(Annotation( "GOC:tfm") "A mesenchymal stem cell of the vertebrae.") +AnnotationAssertion(rdfs:label "vertebral mesenchymal stem cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (stromal cell of pancreas) + +AnnotationAssertion(Annotation( "GOC:tfm") "A stromal cell of the pancreas.") +AnnotationAssertion(rdfs:label "stromal cell of pancreas") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (central nervous system pericyte) +AnnotationAssertion(Annotation( "GOC:tfm") "A pericyte of the central nervous system.") AnnotationAssertion(rdfs:label "central nervous system pericyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8440,7 +10633,7 @@ SubClassOf( ObjectSomeValuesFrom( (retinal blood vessel endothelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "A blood vessel endothelial cell that is part of the retina.") AnnotationAssertion(rdfs:label "retinal blood vessel endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8449,6 +10642,7 @@ SubClassOf( ObjectSomeValuesFrom( (smooth muscle cell of the brachiocephalic vasculature) +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell of the bachiocephalic vasculature.") AnnotationAssertion(rdfs:label "smooth muscle cell of the brachiocephalic vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8456,6 +10650,7 @@ SubClassOf( ObjectSomeValuesFrom( (smooth muscle cell of the brain vasculature) +AnnotationAssertion(Annotation( "GOC:tfm") "A vascular associated smooth muscle cell of the brain vasculature.") AnnotationAssertion(rdfs:label "smooth muscle cell of the brain vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8464,7 +10659,8 @@ SubClassOf( ObjectSomeValuesFrom( (smooth muscle cell of the pulmonary artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle of the pulmonary artery.") +AnnotationAssertion( "BTO:0003336") AnnotationAssertion(rdfs:label "smooth muscle cell of the pulmonary artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8472,6 +10668,7 @@ SubClassOf( ObjectSomeValuesFrom( (smooth muscle cell of the subclavian artery) +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell of the subclavian artery.") AnnotationAssertion(rdfs:label "smooth muscle cell of the subclavian artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8479,6 +10676,7 @@ SubClassOf( ObjectSomeValuesFrom( (smooth muscle cell of the carotid artery) +AnnotationAssertion(Annotation( "GOC:tfm") "Smooth muscle cell of the carotid artery.") AnnotationAssertion(rdfs:label "smooth muscle cell of the carotid artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8486,7 +10684,8 @@ SubClassOf( ObjectSomeValuesFrom( (bronchial smooth muscle cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any smooth muscle cell that is part of some bronchus.") +AnnotationAssertion( "BTO:0004402") AnnotationAssertion(rdfs:label "bronchial smooth muscle cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8494,6 +10693,7 @@ SubClassOf( ObjectSomeValuesFrom( (smooth muscle cell of the esophagus) +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell of the esophagus.") AnnotationAssertion(rdfs:label "smooth muscle cell of the esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8501,6 +10701,7 @@ SubClassOf( ObjectSomeValuesFrom( (smooth muscle cell of trachea) +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell of the trachea.") AnnotationAssertion(rdfs:label "smooth muscle cell of trachea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8508,6 +10709,7 @@ SubClassOf( ObjectSomeValuesFrom( (raphe nuclei neuron) +AnnotationAssertion(Annotation( "GOC:tfm") "A neuron of the raphe nuclei.") AnnotationAssertion(rdfs:label "raphe nuclei neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8516,6 +10718,7 @@ SubClassOf( ObjectSomeValuesFrom( (neuron of the ventral spinal cord) +AnnotationAssertion(Annotation( "GOC:tfm") "A neuron of the ventral spinal cord.") AnnotationAssertion(rdfs:label "neuron of the ventral spinal cord") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8524,7 +10727,9 @@ SubClassOf( ObjectSomeValuesFrom( (skin fibroblast) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "A fibroblast of skin.") +AnnotationAssertion( "BTO:0001255") +AnnotationAssertion( "CALOHA:TS-0935") AnnotationAssertion(rdfs:label "skin fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8532,6 +10737,7 @@ SubClassOf( ObjectSomeValuesFrom( (epithelial cell of lower respiratory tract) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any epithelial cell that is part of some lower respiratory tract epithelium.") AnnotationAssertion(rdfs:label "epithelial cell of lower respiratory tract") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8539,18 +10745,33 @@ SubClassOf( ObjectSomeValuesFrom( (squamous endothelial cell) +AnnotationAssertion(Annotation( "GOC:dos") "A squamous shaped endothelial cell.") AnnotationAssertion(rdfs:label "squamous endothelial cell") SubClassOf( ) # Class: (glandular cell of esophagus) +AnnotationAssertion(Annotation( "GOC:tfm") "A glandular epithelial cell of the esophagus.") +AnnotationAssertion( "FMA:86548") AnnotationAssertion(rdfs:label "glandular cell of esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (glandular cell of the large intestine) + +AnnotationAssertion(Annotation( "GOC:tfm") "A glandular epithelial cell of the large intestine.") +AnnotationAssertion( "FMA:87194") +AnnotationAssertion(rdfs:label "glandular cell of the large intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (glandular cell of stomach) +AnnotationAssertion(Annotation( "GOC:tfm") "A glandular epithelial cell that is part of the stomach.") +AnnotationAssertion( "CALOHA:TS-1284") +AnnotationAssertion( "FMA:86554") AnnotationAssertion(rdfs:label "glandular cell of stomach") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8558,6 +10779,8 @@ SubClassOf( (myocardial endocrine cell of atrium) +AnnotationAssertion(Annotation( "GOC:tfm") "A myocardial endocrine cell that is part of the atrium.") +AnnotationAssertion( "FMA:83389") AnnotationAssertion(rdfs:label "myocardial endocrine cell of atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8565,11 +10788,14 @@ SubClassOf( ObjectSomeValuesFrom( (cardioblast) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:19745164") "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart.") +AnnotationAssertion(rdfs:comment "Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell.") AnnotationAssertion(rdfs:label "cardioblast") SubClassOf( ) # Class: (retinal progenitor cell) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:20959166") Annotation( "PMID:21148186") "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells.") AnnotationAssertion(rdfs:label "retinal progenitor cell") SubClassOf( ) SubClassOf( ) @@ -8577,13 +10803,24 @@ SubClassOf( ObjectSomeValuesFrom( (neural crest derived neuroblast) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:17407019") "A neuroblast derived from a neural crest cell.") AnnotationAssertion(rdfs:label "neural crest derived neuroblast") SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (PP cell of intestine) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:2420136") Annotation( "PMID:728970") "A PP cell found in intestine.") +AnnotationAssertion(rdfs:label "PP cell of intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (spinal cord interneuron) +AnnotationAssertion(Annotation( "CL:CVS") "A CNS interneuron located in the spinal cord.") +AnnotationAssertion(rdfs:comment "Is_a interneuron, part_of UBERON:0002240.") AnnotationAssertion(rdfs:label "spinal cord interneuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8591,16 +10828,26 @@ SubClassOf( ObjectSomeValuesFrom( (multi-ciliated epithelial cell) +AnnotationAssertion(Annotation( "CL:CVS") "A ciliated epithelial cell with many cilia.") AnnotationAssertion(rdfs:label "multi-ciliated epithelial cell") SubClassOf( ) +# Class: (hepatoblast) + +AnnotationAssertion(Annotation( "GOC:CVS") Annotation( "PMID:18356246") Annotation( "PMID:20483998") Annotation( "PMID:26798363") Annotation( "https://orcid.org/0000-0003-1940-6740") "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation.") +AnnotationAssertion(rdfs:label "hepatoblast"@en) +SubClassOf( ) + # Class: (skeletogenic cell) +AnnotationAssertion(Annotation( "GO_REF:0000034") "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized).") +AnnotationAssertion(rdfs:comment "Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)") AnnotationAssertion(rdfs:label "skeletogenic cell") SubClassOf( ) # Class: (premigratory neural crest cell) +AnnotationAssertion(Annotation( "UBERONREF:0000002") "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells.") AnnotationAssertion(rdfs:label "premigratory neural crest cell") SubClassOf( ) SubClassOf( ) @@ -8609,21 +10856,26 @@ SubClassOf( ObjectSomeValuesFrom( (prechondroblast) +AnnotationAssertion(Annotation( "GO_REF:0000034") "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells.") AnnotationAssertion(rdfs:label "prechondroblast") SubClassOf( ) # Class: (non-striated muscle cell) +AnnotationAssertion(Annotation( "GOC:DOS") "Any muscle cell in which the fibers are not organised into sarcomeres.") AnnotationAssertion(rdfs:label "non-striated muscle cell") SubClassOf( ) # Class: (hematopoietic precursor cell) +AnnotationAssertion(Annotation( "GOC:dos") "Any hematopoietic cell that is a precursor of some other hematopoietic cell type.") AnnotationAssertion(rdfs:label "hematopoietic precursor cell") SubClassOf( ) # Class: (skeletal muscle fiber) +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "ISBN:0323052908") "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.") +AnnotationAssertion( "MESH:D018485") AnnotationAssertion(rdfs:label "skeletal muscle fiber"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8632,6 +10884,7 @@ SubClassOf( ObjectSomeValuesFrom( (visceral muscle cell) +AnnotationAssertion(Annotation( "GOC:dos") "A muscle cell that is part of some visceral muscle.") AnnotationAssertion(rdfs:label "visceral muscle cell"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8639,6 +10892,7 @@ SubClassOf( ObjectSomeValuesFrom( (striated visceral muscle cell) +AnnotationAssertion(Annotation( "GOC:dos") "A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods.") AnnotationAssertion(rdfs:label "striated visceral muscle cell"@en) EquivalentClasses( ObjectIntersectionOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )))) SubClassOf( ) @@ -8646,6 +10900,7 @@ SubClassOf( (transversely striated visceral muscle cell) +AnnotationAssertion(Annotation( "GOC:dos") "A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods.") AnnotationAssertion(rdfs:label "transversely striated visceral muscle cell"@en) EquivalentClasses( ObjectIntersectionOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( )))) SubClassOf( ) @@ -8653,6 +10908,8 @@ SubClassOf( ObjectSomeValuesFrom( (adult skeletal muscle myoblast) +AnnotationAssertion(Annotation( "PMID:23303905") "A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers.") +AnnotationAssertion(rdfs:comment "The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins.") AnnotationAssertion(rdfs:label "adult skeletal muscle myoblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8661,7 +10918,6 @@ SubClassOf( (mesenchymal cell) AnnotationAssertion( "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.") -AnnotationAssertion( ) AnnotationAssertion(rdfs:label "mesenchymal cell") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -8669,14 +10925,24 @@ SubClassOf( ObjectSomeValuesFrom( (endocardial cushion cell) +AnnotationAssertion(Annotation( "PMID:18816864") "A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves.") AnnotationAssertion(rdfs:label "endocardial cushion cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreatic endocrine cell) + +AnnotationAssertion(Annotation( "GOC:dos") "An endocrine cell that is part of the pancreas.") +AnnotationAssertion(rdfs:label "pancreatic endocrine cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (visual system neuron) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any neuron that is capable of part of some visual perception.") AnnotationAssertion(rdfs:label "visual system neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8684,12 +10950,13 @@ SubClassOf( ObjectSomeValuesFrom( (mural cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wiki:Mural_cell&oldid=930603194") "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation.") AnnotationAssertion(rdfs:label "mural cell"@en) SubClassOf( ) # Class: (microcirculation associated smooth muscle cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel.") AnnotationAssertion(rdfs:label "microcirculation associated smooth muscle cell"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8698,6 +10965,7 @@ SubClassOf( ObjectSomeValuesFrom( (sensory neuron of spinal nerve) +AnnotationAssertion(Annotation( "GOC:nv") Annotation( "GOC:pr") "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord.") AnnotationAssertion(rdfs:label "sensory neuron of spinal nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8706,6 +10974,8 @@ SubClassOf( ObjectSomeValuesFrom( (compound eye retinal cell) AnnotationAssertion( "Any cell in the compound eye, a light sensing organ composed of ommatidia.") +AnnotationAssertion( "GOC:pr") +AnnotationAssertion( "PMID:12021768") AnnotationAssertion(rdfs:label "compound eye retinal cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( ))))) SubClassOf( ) @@ -8713,26 +10983,173 @@ SubClassOf( ObjectSomeValuesFrom( (retinal cell) +AnnotationAssertion(Annotation( "GOC:pr") "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.") +AnnotationAssertion( "PMID:10702418") AnnotationAssertion(rdfs:label "retinal cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (enteroendocrine cell of small intestine) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "An enteroendocrine cell that is located in the small intestine.") +AnnotationAssertion(rdfs:label "enteroendocrine cell of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (lymphocyte of large intestine lamina propria) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0003-4183-8865") "A lymphocyte that resides in the lamina propria of the large intestine.") +AnnotationAssertion(rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.") +AnnotationAssertion(rdfs:label "lymphocyte of large intestine lamina propria") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (stromal cell of lamina propria of large intestine) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-4183-8865") "A stromal cell found in the lamina propria of the large intestine.") +AnnotationAssertion(rdfs:label "stromal cell of lamina propria of large intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (stromal cell of lamina propria of small intestine) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-4183-8865") "A stromal cell found in the lamina propria of the small intestine.") +AnnotationAssertion(rdfs:label "stromal cell of lamina propria of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mesothelial cell of small intestine) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-4183-8865") "A mesothelial cell that is part of the small intestine.") +AnnotationAssertion(rdfs:label "mesothelial cell of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (mesothelial cell of colon) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") Annotation( "http://orcid.org/0000-0003-4183-8865") "A mesothelial cell that is part of the colon.") +AnnotationAssertion(rdfs:label "mesothelial cell of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (colon macrophage) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "A macrophage that is located in the colon.") +AnnotationAssertion(rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.") +AnnotationAssertion(rdfs:label "colon macrophage") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (stromal cell of lamina propria of colon) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "A stromal cell found in the lamina propria of the colon.") +AnnotationAssertion(rdfs:label "stromal cell of lamina propria of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (enteroendocrine cell of colon) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "An enteroendocrine cell that is located in the colon.") +AnnotationAssertion(rdfs:label "enteroendocrine cell of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (lymphocyte of small intestine lamina propria) + +AnnotationAssertion(Annotation( "PMID:26551552") Annotation( "https://orcid.org/0000-0003-4183-8865") "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response.") +AnnotationAssertion(rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.") +AnnotationAssertion(rdfs:label "lymphocyte of small intestine lamina propria") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (anorectum macrophage) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "A macrophage that is located in the anorectum.") +AnnotationAssertion(rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.") +AnnotationAssertion(rdfs:label "anorectum macrophage") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (T cell of anorectum) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "A T cell that is located in the anorectum.") +AnnotationAssertion(rdfs:comment "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.") +AnnotationAssertion(rdfs:label "T cell of anorectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (smooth muscle cell of anorectum) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "A smooth muscle cell that is located in the anorectum.") +AnnotationAssertion(rdfs:label "smooth muscle cell of anorectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (stromal cell of anorectum lamina propria) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "A stromal cell found in the lamina propria of the anorectum.") +AnnotationAssertion(rdfs:label "stromal cell of anorectum lamina propria") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (enteroendocrine cell of anorectum) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "An enteroendocrine cell that is located in the anorectum.") +AnnotationAssertion(rdfs:label "enteroendocrine cell of anorectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (lung pericyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0003-3440-1876") Annotation( "https://orcid.org/0000-0003-4183-8865") "A pericyte cell that is part of a lung.") +AnnotationAssertion( "EFO:0010669") AnnotationAssertion(rdfs:label "lung pericyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (endothelial cell of hepatic portal vein) + +AnnotationAssertion(Annotation( "PMID:30348985") Annotation( "https://orcid.org/0000-0003-3440-1876") Annotation( "https://orcid.org/0000-0003-4183-8865") "An endothelial cell that is part of a hepatic portal vein.") +AnnotationAssertion( "EFO:0010704") +AnnotationAssertion(rdfs:label "endothelial cell of hepatic portal vein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (embryonic skeletal muscle fiber) +AnnotationAssertion(Annotation( "PMID:32094117") Annotation( "PMID:7196501") Annotation( "http://orcid.org/0000-0003-2034-601X") "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development.") AnnotationAssertion(rdfs:label "embryonic skeletal muscle fiber") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepatic portal fibroblast) + +AnnotationAssertion(Annotation( "PMID:20209607") Annotation( "PMID:24814904") Annotation( "https://orcid.org/0000-0001-7655-4833") "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen.") +AnnotationAssertion(rdfs:label "hepatic portal fibroblast") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (stromal cell of bone marrow) AnnotationAssertion( "A stromal cell that is part_of a bone marrow.") @@ -8744,6 +11161,8 @@ SubClassOf( (epithelial cell of alveolus of lung) AnnotationAssertion( "An epithelial cell that is part_of a alveolus of lung.") +AnnotationAssertion( "MESH:D056809") +AnnotationAssertion(rdfs:comment "May be merged with pneumocyte in future") AnnotationAssertion(rdfs:label "epithelial cell of alveolus of lung") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8759,6 +11178,7 @@ SubClassOf( (cardiac blood vessel endothelial cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any blood vessel endothelial cell that is part of some heart.") AnnotationAssertion(rdfs:label "cardiac blood vessel endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8766,6 +11186,7 @@ SubClassOf( (His-Purkinje system cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any cell that is part of some His-Purkinje system.") AnnotationAssertion(rdfs:label "His-Purkinje system cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8773,7 +11194,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac endothelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any endothelial cell that is part of some heart.") AnnotationAssertion(rdfs:label "cardiac endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8782,6 +11203,7 @@ SubClassOf( ObjectSomeValuesFrom( (camera-type eye photoreceptor cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any photoreceptor cell that is part of some camera-type eye.") AnnotationAssertion(rdfs:label "camera-type eye photoreceptor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8792,11 +11214,13 @@ SubClassOf( ObjectSomeValuesFrom( (zygote) AnnotationAssertion( "A zygote in a plant or an animal.") +AnnotationAssertion( "MESH:D015053") AnnotationAssertion(rdfs:label "zygote"@en) SubClassOf( ) # Class: (cardiac glial cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any glial cell that is part of some heart.") AnnotationAssertion(rdfs:label "cardiac glial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8805,6 +11229,8 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac myoblast) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any myoblast that develops into some cardiac muscle cell.") +AnnotationAssertion( "MESH:D032386") AnnotationAssertion(rdfs:label "cardiac myoblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8812,6 +11238,8 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac neuron) +AnnotationAssertion(Annotation( "PMID:12486170") Annotation( "PMID:29265764") "A neuron that has its soma in the heart.") +AnnotationAssertion(rdfs:comment "This term is used in 3 GO terms that were created as part of the heart development focus project.") AnnotationAssertion(rdfs:label "cardiac neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8819,6 +11247,7 @@ SubClassOf( ObjectSomeValuesFrom( (spinal cord motor neuron) +AnnotationAssertion(Annotation( "GOC:nv") "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.") AnnotationAssertion(rdfs:label "spinal cord motor neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8827,6 +11256,7 @@ SubClassOf( ObjectSomeValuesFrom( (paraxial cell) +AnnotationAssertion(Annotation( "GOC:NV") Annotation( "PMID:11687492") "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites.") AnnotationAssertion(rdfs:label "paraxial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8834,6 +11264,7 @@ SubClassOf( ObjectSomeValuesFrom( (neural crest cell) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0001-5208-3432") Annotation( "https://orcid.org/0000-0002-9900-7880") "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.") AnnotationAssertion(rdfs:label "neural crest cell") SubClassOf( ) SubClassOf( ) @@ -8865,6 +11296,7 @@ SubClassOf( ObjectSomeValuesFrom( (progenitor cell) +AnnotationAssertion(Annotation( "ISBN:978-1-62808-994-3") Annotation( "https://doi.org/10.1016/B978-0-12-409503-8.00002-0") "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses.") AnnotationAssertion(rdfs:label "progenitor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8873,6 +11305,7 @@ SubClassOf( ObjectSomeValuesFrom( (skeletal muscle fibroblast) +AnnotationAssertion(Annotation( "PMID:28369879") Annotation( "https://orcid.org/0000-0001-6164-0667") "Any fibroblast that is part of skeletal muscle tissue.") AnnotationAssertion(rdfs:label "skeletal muscle fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8880,13 +11313,24 @@ SubClassOf( (dermal microvascular endothelial cell) +AnnotationAssertion(Annotation( "BTO:0004574") Annotation( "CL:patterns/cellPartOfAnatomicalEntity") "Any microvascular endothelial cell that is part of the dermis.") AnnotationAssertion(rdfs:label "dermal microvascular endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (colon epithelial cell) + +AnnotationAssertion(Annotation( "GOC:NV") "Epithelial cell that is part of the colon epithelium.") +AnnotationAssertion(rdfs:label "colon epithelial cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (precursor cell) +AnnotationAssertion(Annotation( "GOC:dos") "A cell that, by division or terminal differentiation, can give rise to other cell types.") +AnnotationAssertion(rdfs:comment "Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell.") AnnotationAssertion(rdfs:label "precursor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8894,6 +11338,7 @@ SubClassOf( ObjectSomeValuesFrom( (neutrophillic cytoplasm) +AnnotationAssertion(Annotation( "GOC:add") "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain.") AnnotationAssertion(rdfs:label "neutrophillic cytoplasm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8901,6 +11346,7 @@ SubClassOf( ObjectSomeValuesFrom( (acidophilic cytoplasm) +AnnotationAssertion(Annotation( "GOC:add") "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain.") AnnotationAssertion(rdfs:label "acidophilic cytoplasm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8908,6 +11354,7 @@ SubClassOf( ObjectSomeValuesFrom( (basophilic cytoplasm) +AnnotationAssertion(Annotation( "GOC:tfm") "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions.") AnnotationAssertion(rdfs:label "basophilic cytoplasm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8915,6 +11362,7 @@ SubClassOf( ObjectSomeValuesFrom( (polychromatophilic cytoplasm) +AnnotationAssertion(Annotation( "GOC:tfm") "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions.") AnnotationAssertion(rdfs:label "polychromatophilic cytoplasm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8931,7 +11379,6 @@ SubClassOf( ObjectSomeValuesFrom( (tracheobronchial chondrocyte) AnnotationAssertion( "Any chondrocyte that is part of the tracheobronchial tree.") -AnnotationAssertion( ) AnnotationAssertion(rdfs:label "tracheobronchial chondrocyte"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8939,7 +11386,7 @@ SubClassOf( ObjectSomeValuesFrom( (blood vessel smooth muscle cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:9108778") "A smooth muscle cell that is part of any blood vessel.") AnnotationAssertion(rdfs:label "blood vessel smooth muscle cell"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8947,14 +11394,41 @@ SubClassOf( ObjectSomeValuesFrom( (tracheobronchial smooth muscle cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:10853867") "A smooth muscle cell that is part of the tracheobronchial tree.") AnnotationAssertion(rdfs:label "tracheobronchial smooth muscle cell"@en) EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (extrahepatic cholangiocyte) + +AnnotationAssertion(Annotation( "PMID:23720296") "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes.") +AnnotationAssertion(rdfs:label "extrahepatic cholangiocyte"@en) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (endothelial cell of periportal hepatic sinusoid) + +AnnotationAssertion(Annotation( "PMID:27423426") "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid.") +AnnotationAssertion( "EFO:0010705") +AnnotationAssertion(rdfs:label "endothelial cell of periportal hepatic sinusoid"@en) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (endothelial cell of pericentral hepatic sinusoid) + +AnnotationAssertion(Annotation( "PMID:27423426") "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid.") +AnnotationAssertion( "EFO:0010706") +AnnotationAssertion(rdfs:label "endothelial cell of pericentral hepatic sinusoid"@en) +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (stomach neuroendocrine cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any neuroendocrine cell that is part of some stomach.") AnnotationAssertion(rdfs:label "stomach neuroendocrine cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8963,7 +11437,7 @@ SubClassOf( (lung neuroendocrine cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:33355253") Annotation( "doi:10.3109/01902148209069653") Annotation( "doi:10.7554/eLife.78216") "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury.") AnnotationAssertion(rdfs:label "lung neuroendocrine cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8977,7 +11451,7 @@ SubClassOf( ObjectSomeValuesFrom( (lung ciliated cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any ciliated cell that is part of some lung.") AnnotationAssertion(rdfs:label "lung ciliated cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8985,6 +11459,7 @@ SubClassOf( ObjectSomeValuesFrom( (lung secretory cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any secretory cell that is part of some lung.") AnnotationAssertion(rdfs:label "lung secretory cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -8995,8 +11470,64 @@ SubClassOf( ObjectSomeValuesFrom( "trophectodermal cell") SubClassOf( ) +# Class: (smooth muscle cell of small intestine) + +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell that is part of the small intestine.") +AnnotationAssertion( "FMA:15050") +AnnotationAssertion(rdfs:label "smooth muscle cell of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (smooth muscle fiber of duodenum) + +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell that is part of the duodenum.") +AnnotationAssertion( "FMA:15058") +AnnotationAssertion(rdfs:label "smooth muscle fiber of duodenum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (smooth muscle cell of large intestine) + +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell that is part of the large intestine.") +AnnotationAssertion( "FMA:15653") +AnnotationAssertion(rdfs:label "smooth muscle cell of large intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (smooth muscle cell of colon) + +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell that is part of the colon.") +AnnotationAssertion( "FMA:15663") +AnnotationAssertion(rdfs:label "smooth muscle cell of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (smooth muscle cell of sigmoid colon) + +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell that is part of the sigmoid colon.") +AnnotationAssertion( "FMA:17521") +AnnotationAssertion(rdfs:label "smooth muscle cell of sigmoid colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (smooth muscle cell of rectum) + +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell that is part of the rectum.") +AnnotationAssertion( "FMA:17522") +AnnotationAssertion(rdfs:label "smooth muscle cell of rectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (fibroblast of areolar connective tissue) +AnnotationAssertion(Annotation( "GOC:tfm") "A fibroblast that is part of the areolar connective tissue.") +AnnotationAssertion( "FMA:261279") AnnotationAssertion(rdfs:label "fibroblast of areolar connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9004,6 +11535,8 @@ SubClassOf( ObjectSomeValuesFrom( (fibroblast of tunica adventitia of artery) +AnnotationAssertion(Annotation( "GOC:tfm") "A fibroblast that is part of the tunica adventitia of artery.") +AnnotationAssertion( "FMA:261285") AnnotationAssertion(rdfs:label "fibroblast of tunica adventitia of artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9012,6 +11545,8 @@ SubClassOf( ObjectSomeValuesFrom( (fibroblast of dense regular elastic tissue) +AnnotationAssertion(Annotation( "GOC:tfm") "A fibroblast that is part of the dense regular elastic tissue.") +AnnotationAssertion( "FMA:261287") AnnotationAssertion(rdfs:label "fibroblast of dense regular elastic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9020,7 +11555,8 @@ SubClassOf( ObjectSomeValuesFrom( (epicardial adipocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "An adipocyte that is part of the epicardial fat.") +AnnotationAssertion( "FMA:261293") AnnotationAssertion(rdfs:label "epicardial adipocyte") SubClassOf( ) SubClassOf( ) @@ -9028,6 +11564,8 @@ SubClassOf( ObjectSomeValuesFrom( (adipocyte of epicardial fat of right ventricle) +AnnotationAssertion(Annotation( "GOC:tfm") "An adipocyte that is part of the epicardial fat of right ventricle.") +AnnotationAssertion( "FMA:261297") AnnotationAssertion(rdfs:label "adipocyte of epicardial fat of right ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9035,6 +11573,8 @@ SubClassOf( ObjectSomeValuesFrom( (adipocyte of epicardial fat of left ventricle) +AnnotationAssertion(Annotation( "GOC:tfm") "An adipocyte that is part of the epicardial fat of left ventricle.") +AnnotationAssertion( "FMA:261300") AnnotationAssertion(rdfs:label "adipocyte of epicardial fat of left ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9042,7 +11582,8 @@ SubClassOf( ObjectSomeValuesFrom( (serous cell of epithelium of trachea) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "A serous secreting cell that is part of the epithelium of trachea.") +AnnotationAssertion( "FMA:263078") AnnotationAssertion(rdfs:label "serous cell of epithelium of trachea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9050,7 +11591,8 @@ SubClassOf( ObjectSomeValuesFrom( (serous cell of epithelium of bronchus) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "A serous secreting cell that is part of the epithelium of bronchus.") +AnnotationAssertion( "FMA:263080") AnnotationAssertion(rdfs:label "serous cell of epithelium of bronchus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9058,6 +11600,8 @@ SubClassOf( ObjectSomeValuesFrom( (serous cell of epithelium of terminal bronchiole) +AnnotationAssertion(Annotation( "GOC:tfm") "A serous secreting cell that is part of the epithelium of terminal bronchiole.") +AnnotationAssertion( "FMA:263082") AnnotationAssertion(rdfs:label "serous cell of epithelium of terminal bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9066,6 +11610,8 @@ SubClassOf( ObjectSomeValuesFrom( (transitional myocyte of interatrial septum) +AnnotationAssertion(Annotation( "GOC:tfm") "A transitional myocyte that is part of the interatrial septum.") +AnnotationAssertion( "FMA:263152") AnnotationAssertion(rdfs:label "transitional myocyte of interatrial septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9074,6 +11620,8 @@ SubClassOf( ObjectSomeValuesFrom( (transitional myocyte of interventricular septum) +AnnotationAssertion(Annotation( "GOC:tfm") "A transitional myocyte that is part of the interventricular septum.") +AnnotationAssertion( "FMA:263154") AnnotationAssertion(rdfs:label "transitional myocyte of interventricular septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9082,14 +11630,29 @@ SubClassOf( ObjectSomeValuesFrom( (Purkinje myocyte of interventricular septum) +AnnotationAssertion(Annotation( "GOC:tfm") "A Purkinje myocyte that is part of the interventricular septum.") +AnnotationAssertion( "FMA:263182") AnnotationAssertion(rdfs:label "Purkinje myocyte of interventricular septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (endothelial cell of hepatic sinusoid) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:3926620") "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates.") +AnnotationAssertion( "BTO:000125") +AnnotationAssertion( "FMA:62911") +AnnotationAssertion(rdfs:label "endothelial cell of hepatic sinusoid") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (myocyte of sinoatrial node) +AnnotationAssertion(Annotation( "FMA:67102") Annotation( "GOC:tfm") "A muscle cell that is part of the sinoatrial node.") +AnnotationAssertion( "FMA:67102") AnnotationAssertion(rdfs:label "myocyte of sinoatrial node") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9098,6 +11661,8 @@ SubClassOf( ObjectSomeValuesFrom( (myocyte of atrioventricular node) +AnnotationAssertion(Annotation( "FMA:67106") Annotation( "GOC:tfm") "A muscle cell that is part of the atrioventricular node.") +AnnotationAssertion( "FMA:67106") AnnotationAssertion(rdfs:label "myocyte of atrioventricular node") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9107,7 +11672,9 @@ SubClassOf( ObjectSomeValuesFrom( (endothelial cell of arteriole) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "An endothelial cell that is part of the arteriole.") +AnnotationAssertion( "FMA:67760") +AnnotationAssertion( "KUPO:0001097") AnnotationAssertion(rdfs:label "endothelial cell of arteriole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9115,7 +11682,10 @@ SubClassOf( ObjectSomeValuesFrom( (endothelial cell of artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "A blood vessel endothelial cell that is part of an arterial endothelium.") +AnnotationAssertion( "BTO:0004758") +AnnotationAssertion( "FMA:67761") +AnnotationAssertion( "KUPO:0001095") AnnotationAssertion(rdfs:label "endothelial cell of artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9123,14 +11693,26 @@ SubClassOf( ObjectSomeValuesFrom( (endothelial cell of venule) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "An endothelial cell that is part of the venule.") +AnnotationAssertion( "FMA:67762") AnnotationAssertion(rdfs:label "endothelial cell of venule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelial cell of gallbladder) + +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell that is part of the gallbladder.") +AnnotationAssertion( "FMA:67780") +AnnotationAssertion(rdfs:label "epithelial cell of gallbladder") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (stem cell of epidermis) +AnnotationAssertion(Annotation( "GOC:tfm") "A somatic stem cell that is part of the epidermis.") +AnnotationAssertion( "FMA:70541") AnnotationAssertion(rdfs:label "stem cell of epidermis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9138,6 +11720,8 @@ SubClassOf( ObjectSomeValuesFrom( (ciliary muscle cell) +AnnotationAssertion(Annotation( "GOC:tfm") "A smooth muscle cell that is part of the ciliary body.") +AnnotationAssertion( "FMA:70610") AnnotationAssertion(rdfs:label "ciliary muscle cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9145,6 +11729,8 @@ SubClassOf( ObjectSomeValuesFrom( (mesothelial cell of anterior chamber of eye) +AnnotationAssertion(Annotation( "GOC:tfm") "A mesothelial cell that is part of the anterior chamber of eyeball.") +AnnotationAssertion( "FMA:70615") AnnotationAssertion(rdfs:label "mesothelial cell of anterior chamber of eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9152,6 +11738,8 @@ SubClassOf( ObjectSomeValuesFrom( (mesothelial cell of parietal peritoneum) +AnnotationAssertion(Annotation( "GOC:tfm") "A mesothelial cell that is part of the parietal peritoneum.") +AnnotationAssertion( "FMA:72142") AnnotationAssertion(rdfs:label "mesothelial cell of parietal peritoneum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9159,7 +11747,8 @@ SubClassOf( ObjectSomeValuesFrom( (mesothelial cell of visceral peritoneum) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "A mesothelial cell that is part of the visceral peritoneum.") +AnnotationAssertion( "FMA:72143") AnnotationAssertion(rdfs:label "mesothelial cell of visceral peritoneum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9167,6 +11756,8 @@ SubClassOf( ObjectSomeValuesFrom( (transitional myocyte of sinoatrial node) +AnnotationAssertion(Annotation( "GOC:tfm") "A transitional myocyte that is part of the sinoatrial node.") +AnnotationAssertion( "FMA:83384") AnnotationAssertion(rdfs:label "transitional myocyte of sinoatrial node") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9174,6 +11765,8 @@ SubClassOf( (Purkinje myocyte of atrioventricular node) +AnnotationAssertion(Annotation( "GOC:tfm") "A Purkinje myocyte that is part of the atrioventricular node.") +AnnotationAssertion( "FMA:83386") AnnotationAssertion(rdfs:label "Purkinje myocyte of atrioventricular node") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9181,14 +11774,30 @@ SubClassOf( (myocardial endocrine cell of interventricular septum) +AnnotationAssertion(Annotation( "GOC:tfm") "A myocardial endocrine cell that is part of the interventricular septum.") +AnnotationAssertion( "FMA:83390") AnnotationAssertion(rdfs:label "myocardial endocrine cell of interventricular septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (cholangiocyte) + +AnnotationAssertion(Annotation( "GOC:tfm") Annotation( "PMID:16550043") Annotation( "PMID:18356246") "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.") +AnnotationAssertion( "FMA:86481") +AnnotationAssertion(rdfs:label "cholangiocyte") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( ObjectIntersectionOf( ObjectSomeValuesFrom( )))) + # Class: (mesothelial cell of peritoneum) +AnnotationAssertion(Annotation( "GOC:tfm") "A mesothelial cell that is part of the peritoneum.") +AnnotationAssertion( "FMA:86736") AnnotationAssertion(rdfs:label "mesothelial cell of peritoneum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9196,6 +11805,8 @@ SubClassOf( ObjectSomeValuesFrom( (mesothelial cell of pleura) +AnnotationAssertion(Annotation( "GOC:tfm") "A mesothelial cell that is part of the pleura.") +AnnotationAssertion( "FMA:86737") AnnotationAssertion(rdfs:label "mesothelial cell of pleura") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9203,6 +11814,8 @@ SubClassOf( ObjectSomeValuesFrom( (mesothelial cell of parietal pleura) +AnnotationAssertion(Annotation( "GOC:tfm") "A mesothelial cell that is part of the parietal pleura.") +AnnotationAssertion( "FMA:86738") AnnotationAssertion(rdfs:label "mesothelial cell of parietal pleura") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9210,14 +11823,33 @@ SubClassOf( ObjectSomeValuesFrom( (mesothelial cell of visceral pleura) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:tfm") "A mesothelial cell that is part of the visceral pleura.") +AnnotationAssertion( "FMA:86739") AnnotationAssertion(rdfs:label "mesothelial cell of visceral pleura") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelial cell of exocrine pancreas) + +AnnotationAssertion(Annotation( "GOC:tfm") "An epithelial cell of the exocrine pancreas.") +AnnotationAssertion( "FMA:70986") +AnnotationAssertion(rdfs:label "epithelial cell of exocrine pancreas") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (intestinal enteroendocrine cell) + +AnnotationAssertion(Annotation( "MP:0010802") "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract.") +AnnotationAssertion(rdfs:label "intestinal enteroendocrine cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (lung endothelial cell) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any endothelial cell of vascular tree that is part of some lung.") AnnotationAssertion(rdfs:label "lung endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9225,22 +11857,96 @@ SubClassOf( ObjectSomeValuesFrom( (pulmonary artery endothelial cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FBC:Autogenerated") "Any endothelial cell of vascular tree that is part of some pulmonary artery.") +AnnotationAssertion( "BTO:0001141") AnnotationAssertion(rdfs:label "pulmonary artery endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (colon endothelial cell) + +AnnotationAssertion(Annotation( "NPX:PDR") Annotation( "https://orcid.org/0000-0001-5208-3432") "A vascular endothelial cell found in colon blood vessels.") +AnnotationAssertion( "CALOHA:TS-2397") +AnnotationAssertion(rdfs:label "colon endothelial cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (oral mucosa squamous cell) +AnnotationAssertion(Annotation( "NPX:PDR") "Squamous cell of oral epithelium.") +AnnotationAssertion( "CALOHA:TS-1252") AnnotationAssertion(rdfs:label "oral mucosa squamous cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (colon glandular cell) + +AnnotationAssertion(Annotation( "NPX:PDR") "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells.") +AnnotationAssertion( "CALOHA:TS-1274") +AnnotationAssertion(rdfs:label "colon glandular cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (duodenum glandular cell) + +AnnotationAssertion(Annotation( "NPX:PDR") "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell.") +AnnotationAssertion( "CALOHA:TS-1275") +AnnotationAssertion(rdfs:label "duodenum glandular cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (gallbladder glandular cell) + +AnnotationAssertion(Annotation( "NPX:PDR") "Glandular cell of gallbladder epithelium.") +AnnotationAssertion( "CALOHA:TS-1278") +AnnotationAssertion(rdfs:label "gallbladder glandular cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (rectum glandular cell) + +AnnotationAssertion(Annotation( "NPX:PDR") "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells.") +AnnotationAssertion( "CALOHA:TS-1281") +AnnotationAssertion(rdfs:label "rectum glandular cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (small intestine glandular cell) + +AnnotationAssertion(Annotation( "NCI_Thesaurus:Small_Intestinal_Glandular_Cell") Annotation( "NPX:PDR") "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) .") +AnnotationAssertion( "CALOHA:TS-1286") +AnnotationAssertion( "FMA:86928") +AnnotationAssertion(rdfs:label "small intestine glandular cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreas exocrine glandular cell) + +AnnotationAssertion(Annotation( "HPA:HPA") Annotation( "NPX:PDR") "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts.") +AnnotationAssertion( "BTO:0000028") +AnnotationAssertion( "CALOHA:TS-1242") +AnnotationAssertion(rdfs:label "pancreas exocrine glandular cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (lung macrophage) +AnnotationAssertion(Annotation( "HPA:HPA") Annotation( "NPX:PDR") "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung.") +AnnotationAssertion( "CALOHA:TS-0576") AnnotationAssertion(rdfs:label "lung macrophage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9248,6 +11954,8 @@ SubClassOf( ObjectSomeValuesFrom( (muscle fibroblast) +AnnotationAssertion(Annotation( "NPX:PDR") "Fibroblast from muscle organ.") +AnnotationAssertion( "CALOHA:TS-0643") AnnotationAssertion(rdfs:label "muscle fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9255,6 +11963,8 @@ SubClassOf( ObjectSomeValuesFrom( (bone marrow hematopoietic cell) +AnnotationAssertion(Annotation( "NPX:PDR") "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes.") +AnnotationAssertion( "CALOHA:TS-2109") AnnotationAssertion(rdfs:label "bone marrow hematopoietic cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9263,6 +11973,7 @@ SubClassOf( ObjectSomeValuesFrom( (peripheral blood mononuclear cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood.") AnnotationAssertion(rdfs:label "peripheral blood mononuclear cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9271,6 +11982,7 @@ SubClassOf( ObjectSomeValuesFrom( (microvascular endothelial cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any blood vessel endothelial cell that is part of a microvascular endothelium.") AnnotationAssertion(rdfs:label "microvascular endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9278,6 +11990,7 @@ SubClassOf( ObjectSomeValuesFrom( (dermis blood vessel endothelial cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any blood vessel endothelial cell that is part of a dermis.") AnnotationAssertion(rdfs:label "dermis blood vessel endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9285,6 +11998,7 @@ SubClassOf( ObjectSomeValuesFrom( (fibroblast of skin of abdomen) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any skin fibroblast that is part of a skin of abdomen.") AnnotationAssertion(rdfs:label "fibroblast of skin of abdomen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9292,6 +12006,7 @@ SubClassOf( ObjectSomeValuesFrom( (lung microvascular endothelial cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any lung endothelial cell that is part of a microvascular endothelium.") AnnotationAssertion(rdfs:label "lung microvascular endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9299,6 +12014,7 @@ SubClassOf( (compound eye photoreceptor cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any photoreceptor cell that is part of a compound eye.") AnnotationAssertion(rdfs:label "compound eye photoreceptor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9306,6 +12022,7 @@ SubClassOf( ObjectSomeValuesFrom( (inner cell mass cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any native cell that is part of a inner cell mass.") AnnotationAssertion(rdfs:label "inner cell mass cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9313,6 +12030,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac septum cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any native cell that is part of a cardiac septum.") AnnotationAssertion(rdfs:label "cardiac septum cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9320,6 +12038,7 @@ SubClassOf( ObjectSomeValuesFrom( (central nervous system neuron) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any neuron that is part of a central nervous system.") AnnotationAssertion(rdfs:label "central nervous system neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9327,7 +12046,8 @@ SubClassOf( ObjectSomeValuesFrom( (peripheral nervous system neuron) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "ISBN:0721662544") "A neuron that is part of a peripheral nervous system.") +AnnotationAssertion( "FMA:84664") AnnotationAssertion(rdfs:label "peripheral nervous system neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9335,6 +12055,7 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic fibroblast) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any fibroblast that is part of a embryo.") AnnotationAssertion(rdfs:label "embryonic fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9342,6 +12063,7 @@ SubClassOf( ObjectSomeValuesFrom( (brain pericyte) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any pericyte cell that is part of a brain.") AnnotationAssertion(rdfs:label "brain pericyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9349,6 +12071,7 @@ SubClassOf( ObjectSomeValuesFrom( (brain microvascular endothelial cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any microvascular endothelial cell that is part of a brain.") AnnotationAssertion(rdfs:label "brain microvascular endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9357,6 +12080,7 @@ SubClassOf( ObjectSomeValuesFrom( (ventricular cardiac muscle cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any cardiac muscle cell that is part of a cardiac ventricle.") AnnotationAssertion(rdfs:label "ventricular cardiac muscle cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9364,14 +12088,43 @@ SubClassOf( ObjectSomeValuesFrom( (brainstem motor neuron) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any motor neuron that is part of a brainstem.") AnnotationAssertion(rdfs:label "brainstem motor neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (splenic fibroblast) + +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any fibroblast that is part of a spleen.") +AnnotationAssertion(rdfs:label "splenic fibroblast") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (splenic endothelial cell) + +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any endothelial cell that is part of a spleen.") +AnnotationAssertion(rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=5500") +AnnotationAssertion(rdfs:label "splenic endothelial cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (liver dendritic cell) + +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any dendritic cell that is part of a liver.") +AnnotationAssertion(rdfs:comment "http://www.jleukbio.org/content/66/2/322.abstract") +AnnotationAssertion(rdfs:label "liver dendritic cell") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (ovarian fibroblast) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any fibroblast that is part of a female gonad.") +AnnotationAssertion(rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7330") AnnotationAssertion(rdfs:label "ovarian fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9379,6 +12132,8 @@ SubClassOf( ObjectSomeValuesFrom( (ovarian surface epithelial cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any epithelial cell that is part of a female gonad.") +AnnotationAssertion(rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7310") AnnotationAssertion(rdfs:label "ovarian surface epithelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9386,7 +12141,8 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac ventricle fibroblast) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any fibroblast that is part of a cardiac ventricle.") +AnnotationAssertion(rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6310") AnnotationAssertion(rdfs:label "cardiac ventricle fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9394,7 +12150,8 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac atrium fibroblast) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any fibroblast that is part of a cardiac atrium.") +AnnotationAssertion(rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6320") AnnotationAssertion(rdfs:label "cardiac atrium fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9402,13 +12159,26 @@ SubClassOf( ObjectSomeValuesFrom( (pericardium fibroblast) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any fibroblast that is part of a pericardium.") +AnnotationAssertion(rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6430") AnnotationAssertion(rdfs:label "pericardium fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (gallbladder fibroblast) + +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any fibroblast that is part of a gallbladder.") +AnnotationAssertion(rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=5430") +AnnotationAssertion(rdfs:label "gallbladder fibroblast") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (optic choroid fibroblast) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any fibroblast that is part of a optic choroid.") +AnnotationAssertion(rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=6620") AnnotationAssertion(rdfs:label "optic choroid fibroblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9416,6 +12186,8 @@ SubClassOf( ObjectSomeValuesFrom( (adipose microvascular endothelial cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any microvascular endothelial cell that is part of a adipose tissue.") +AnnotationAssertion(rdfs:comment "http://www.sciencellonline.com/site/productInformation.php?keyword=7200") AnnotationAssertion(rdfs:label "adipose microvascular endothelial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9424,13 +12196,24 @@ SubClassOf( ObjectSomeValuesFrom( (migratory cardiac neural crest cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any migratory neural crest cell that is part of a cardiac neural crest.") AnnotationAssertion(rdfs:label "migratory cardiac neural crest cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (splenocyte) + +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any leukocyte that is part of a spleen.") +AnnotationAssertion(rdfs:comment "Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology.") +AnnotationAssertion(rdfs:label "splenocyte") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mesenchymal stem cell of abdominal adipose tissue) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any mesenchymal stem cell of adipose tissue that is part of an abdomen.") AnnotationAssertion(rdfs:label "mesenchymal stem cell of abdominal adipose tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9438,6 +12221,7 @@ SubClassOf( ObjectSomeValuesFrom( (bronchus fibroblast of lung) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any fibroblast of lung that is part of a bronchus.") AnnotationAssertion(rdfs:label "bronchus fibroblast of lung") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9445,6 +12229,7 @@ SubClassOf( ObjectSomeValuesFrom( (ciliated epithelial cell of esophagus) +AnnotationAssertion(Annotation( "GOC:CellBLAST") Annotation( "PMID:29802404") "A ciliated epithelial cell of the esophagus.") AnnotationAssertion(rdfs:label "ciliated epithelial cell of esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9453,6 +12238,7 @@ SubClassOf( ObjectSomeValuesFrom( (peripheral sensory neuron) +AnnotationAssertion(Annotation( "GOC:CellBLAST") Annotation( "PMID:30096314") "Peripheral sensory neuron.") AnnotationAssertion(rdfs:label "peripheral sensory neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9460,7 +12246,7 @@ SubClassOf( (brain vascular cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "DOI:10.1101/2022.10.12.511898") "A cell that is part of the brain vasculature.") AnnotationAssertion(rdfs:label "brain vascular cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9468,7 +12254,7 @@ SubClassOf( ObjectSomeValuesFrom( (midbrain-derived inhibitory neuron) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "DOI:10.1101/2022.10.12.511898") "A GABAergic inhibitory neuron that is derived from the midbrain.") AnnotationAssertion(rdfs:label "midbrain-derived inhibitory neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9477,6 +12263,7 @@ SubClassOf( ObjectSomeValuesFrom( (somatosensory neuron) +AnnotationAssertion(Annotation( "PMID:22865660") "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli.") AnnotationAssertion(rdfs:label "somatosensory neuron") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9493,7 +12280,7 @@ SubClassOf( ObjectSomeValuesFrom( (alveolar type 1 fibroblast cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:22268140") Annotation( "PMID:26706109") Annotation( "PMID:28886382") Annotation( "PMID:29489752") Annotation( "PMID:30675802") Annotation( "PMID:33624948") Annotation( "PMID:33707239") Annotation( "PMID:9074756") "A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets.") AnnotationAssertion(rdfs:label "alveolar type 1 fibroblast cell") SubClassOf( ) SubClassOf( ) @@ -9501,7 +12288,7 @@ SubClassOf( ObjectSomeValuesFrom( (alveolar adventitial fibroblast) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:26706109") Annotation( "PMID:28886382") Annotation( "PMID:29752282") Annotation( "PMID:30675802") Annotation( "PMID:33208946") Annotation( "PMID:33624948") "A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia.") AnnotationAssertion(rdfs:label "alveolar adventitial fibroblast") SubClassOf( ) SubClassOf( ) @@ -9509,6 +12296,7 @@ SubClassOf( ObjectSomeValuesFrom( (blood lymphocyte) +AnnotationAssertion(Annotation( ) "A lymphocyte located in blood.") AnnotationAssertion(rdfs:label "blood lymphocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9516,6 +12304,7 @@ SubClassOf( (interstitial cell) +AnnotationAssertion(Annotation( "PMID:24987007") "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes.") AnnotationAssertion(rdfs:label "interstitial cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9523,14 +12312,24 @@ SubClassOf( ObjectSomeValuesFrom( (respiratory ciliated cell) +AnnotationAssertion(Annotation( "PMID:18757316") Annotation( "PMID:21364219") "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium.") AnnotationAssertion(rdfs:label "respiratory ciliated cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (serous secreting cell of bronchus submucosal gland) + +AnnotationAssertion(Annotation( "PMID:5487122") Annotation( "PMID:9651178") "A(n) serous secreting cell that is part of a(n) bronchus submucosal gland.") +AnnotationAssertion(rdfs:label "serous secreting cell of bronchus submucosal gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vein endothelial cell of respiratory system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:34030460") "A(n) vein endothelial cell that is part of a(n) respiratory system.") AnnotationAssertion(rdfs:label "vein endothelial cell of respiratory system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9538,7 +12337,7 @@ SubClassOf( ObjectSomeValuesFrom( (bronchiolar smooth muscle cell) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:9781260462982") Annotation( "PMID:15347627") "A smooth muscle cell that is part of a bronchiole.") AnnotationAssertion(rdfs:label "bronchiolar smooth muscle cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9546,40 +12345,79 @@ SubClassOf( ObjectSomeValuesFrom( (lung megakaryocyte) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:33351116") "A megakaryocyte that is resident in the lung connective tissue.") AnnotationAssertion(rdfs:label "lung megakaryocyte") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mucus secreting cell of trachea gland) + +AnnotationAssertion(Annotation( "PMID:18931053") Annotation( "PMID:29656943") "A mucus secreting cell that is part of a submucosal gland of the trachea.") +AnnotationAssertion(rdfs:label "mucus secreting cell of trachea gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucus secreting cell of bronchus submucosal gland) + +AnnotationAssertion(Annotation( "PMID:19965983") "A mucus secreting cell of a submucosal gland of the bronchus.") +AnnotationAssertion(rdfs:label "mucus secreting cell of bronchus submucosal gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucus secreting cell of tracheobronchial tree submucosal gland) + +AnnotationAssertion(Annotation( "PMID:30864819") "A mucus secreting cell of a submucosal gland of the tracheobronchial tree.") +AnnotationAssertion(rdfs:label "mucus secreting cell of tracheobronchial tree submucosal gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (CCL3-positive alveolar macrophage) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:37291214") "An alveolar macrophage that expresses CCL3.") AnnotationAssertion(rdfs:label "CCL3-positive alveolar macrophage") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (metallothionein-positive alveolar macrophage) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:37291214") "An alveolar macrophage that expresses metallothionein.") AnnotationAssertion(rdfs:label "metallothionein-positive alveolar macrophage") SubClassOf( ) # Class: (perivascular cell) +AnnotationAssertion(Annotation( "PMID:24928499") Annotation( "PMID:27889329") "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics.") AnnotationAssertion(rdfs:label "perivascular cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (endothelial cell of central vein of liver) + +AnnotationAssertion(Annotation( "PMID:28287163") "An endothelial cell that is part of a central vein of liver.") +AnnotationAssertion(rdfs:label "endothelial cell of central vein of liver") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (fetal pre-type II pulmonary alveolar epithelial cell) +AnnotationAssertion(Annotation( "PMID:1316350") "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity.") AnnotationAssertion(rdfs:label "fetal pre-type II pulmonary alveolar epithelial cell") SubClassOf( ) # Class: (mesenchymal stem cell of orbital adipose tissue) +AnnotationAssertion(Annotation( ) "Any mesenchymal stem cell of adipose tissue that is part of an orbital region.") AnnotationAssertion(rdfs:label "mesenchymal stem cell of orbital adipose tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9587,6 +12425,7 @@ SubClassOf( ObjectSomeValuesFrom( (vacuole inheritance) +AnnotationAssertion(Annotation( "GOC:mcc") Annotation( "PMID:10873824") Annotation( "PMID:14616069") "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.") AnnotationAssertion(rdfs:label "vacuole inheritance") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9596,12 +12435,14 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (mitotic sister chromatid segregation) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:jl") "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.") AnnotationAssertion(rdfs:label "mitotic sister chromatid segregation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (Golgi membrane) +AnnotationAssertion(Annotation( "GOC:mah") "The lipid bilayer surrounding any of the compartments of the Golgi apparatus.") AnnotationAssertion(rdfs:label "Golgi membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9609,23 +12450,35 @@ SubClassOf( (microtubule cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.") AnnotationAssertion(rdfs:label "microtubule cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (nuclear chromosome) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.") AnnotationAssertion(rdfs:label "nuclear chromosome") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (polysaccharide biosynthetic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.") AnnotationAssertion(rdfs:label "polysaccharide biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (polysaccharide catabolic process) + +AnnotationAssertion(Annotation( "PMID:33139480") "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.") +AnnotationAssertion(rdfs:label "polysaccharide catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (mitotic cell cycle) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.") +AnnotationAssertion( "Wikipedia:Mitosis") +AnnotationAssertion(rdfs:comment "Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.") AnnotationAssertion(rdfs:label "mitotic cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -9633,54 +12486,71 @@ SubClassOf( ObjectAllValuesFrom( (nuclear division) +AnnotationAssertion(Annotation( "GOC:mah") "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.") AnnotationAssertion(rdfs:label "nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (organellar ribosome) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:mcc") "A ribosome contained within a subcellular membrane-bounded organelle.") AnnotationAssertion(rdfs:label "organellar ribosome") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (lytic vacuole) +AnnotationAssertion(Annotation( "GOC:krc") "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.") AnnotationAssertion(rdfs:label "lytic vacuole") SubClassOf( ) # Class: (nuclear membrane fusion) +AnnotationAssertion(Annotation( "GOC:elh") "The joining of 2 or more lipid bilayer membranes that surround the nucleus.") AnnotationAssertion(rdfs:label "nuclear membrane fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (karyogamy) +AnnotationAssertion(Annotation( "GOC:elh") "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.") +AnnotationAssertion( "Wikipedia:Karyogamy") AnnotationAssertion(rdfs:label "karyogamy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (syncytium formation by plasma membrane fusion) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") Annotation( "GOC:tb") "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.") AnnotationAssertion(rdfs:label "syncytium formation by plasma membrane fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (chromatin) +AnnotationAssertion(Annotation( "GOC:elh") Annotation( "PMID:20404130") "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.") +AnnotationAssertion( "NIF_Subcellular:sao1615953555") +AnnotationAssertion(rdfs:comment "Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.") AnnotationAssertion(rdfs:label "chromatin") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (euchromatin) +AnnotationAssertion(Annotation( "PMID:32017156") "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.") +AnnotationAssertion( "NIF_Subcellular:sao445485807") +AnnotationAssertion( "Wikipedia:Euchromatin") AnnotationAssertion(rdfs:label "euchromatin") SubClassOf( ) # Class: (heterochromatin) +AnnotationAssertion(Annotation( "PMID:32017156") "A compact and highly condensed form of chromatin that is refractory to transcription.") +AnnotationAssertion( "NIF_Subcellular:sao581845896") +AnnotationAssertion( "Wikipedia:Heterochromatin") AnnotationAssertion(rdfs:label "heterochromatin") SubClassOf( ) # Class: (sister chromatid segregation) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:elh") "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.") AnnotationAssertion(rdfs:label "sister chromatid segregation") SubClassOf( ) SubClassOf( ) @@ -9688,23 +12558,30 @@ SubClassOf( (cell morphogenesis) +AnnotationAssertion(Annotation( "GOC:clt") Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "The developmental process in which the size or shape of a cell is generated and organized.") AnnotationAssertion(rdfs:label "cell morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (skeletal system development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:tb") "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).") AnnotationAssertion(rdfs:label "skeletal system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (ossification) +AnnotationAssertion(Annotation( "GOC:mtg_mpo") Annotation( "PMID:17572649") "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.") +AnnotationAssertion( "Wikipedia:Ossification") +AnnotationAssertion(rdfs:comment "Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'.") AnnotationAssertion(rdfs:label "ossification") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (action potential) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") Annotation( "ISBN:978-0-07-139011-8") "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.") +AnnotationAssertion(rdfs:comment "Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so.") AnnotationAssertion(rdfs:label "action potential") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -9713,6 +12590,8 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (angiogenesis) +AnnotationAssertion(Annotation( "ISBN:0878932453") "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.") +AnnotationAssertion( "Wikipedia:Angiogenesis") AnnotationAssertion(rdfs:label "angiogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9721,11 +12600,14 @@ SubClassOf( ObjectSomeValuesFrom( (cilium or flagellum-dependent cell motility) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:hjd") Annotation( "GOC:krc") "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.") +AnnotationAssertion(rdfs:comment "Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC.") AnnotationAssertion(rdfs:label "cilium or flagellum-dependent cell motility") SubClassOf( ) # Class: (oocyte growth) +AnnotationAssertion(Annotation( "https://www.ncbi.nlm.nih.gov/books/NBK279054/") "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.") AnnotationAssertion(rdfs:label "oocyte growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9736,6 +12618,8 @@ SubClassOf( ObjectAllValuesFrom( (oocyte maturation) +AnnotationAssertion(Annotation( "GOC:devbiol") Annotation( "https://www.ncbi.nlm.nih.gov/books/NBK279054/") "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.") +AnnotationAssertion( "Wikipedia:Oocyte_maturation") AnnotationAssertion(rdfs:label "oocyte maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9746,6 +12630,7 @@ SubClassOf( ObjectAllValuesFrom( (regulation of cell growth) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate, extent or direction of cell growth.") AnnotationAssertion(rdfs:label "regulation of cell growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9753,11 +12638,13 @@ SubClassOf( (regulation of cell growth by extracellular stimulus) +AnnotationAssertion(Annotation( "GOC:dph") "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.") AnnotationAssertion(rdfs:label "regulation of cell growth by extracellular stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (blood vessel development) +AnnotationAssertion(Annotation( "GOC:hjd") Annotation( "UBERON:0001981") "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.") AnnotationAssertion(rdfs:label "blood vessel development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9766,6 +12653,7 @@ SubClassOf( ObjectSomeValuesFrom( (branching involved in blood vessel morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.") AnnotationAssertion(rdfs:label "branching involved in blood vessel morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9773,6 +12661,8 @@ SubClassOf( ObjectSomeValuesFrom( (vasculogenesis) +AnnotationAssertion(Annotation( "PMID:8999798") "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.") +AnnotationAssertion( "Wikipedia:Vasculogenesis") AnnotationAssertion(rdfs:label "vasculogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9780,6 +12670,7 @@ SubClassOf( ObjectSomeValuesFrom( (microtubule bundle formation) +AnnotationAssertion(Annotation( "GOC:dph") "A process that results in a parallel arrangement of microtubules.") AnnotationAssertion(rdfs:label "microtubule bundle formation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -9787,29 +12678,46 @@ SubClassOf( ObjectSomeValuesFrom( (eye development) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:jl") "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.") +AnnotationAssertion( "Wikipedia:Eye_development") AnnotationAssertion(rdfs:label "eye development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (urogenital system development) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.") +AnnotationAssertion(rdfs:label "urogenital system development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (temperature homeostasis) +AnnotationAssertion(Annotation( "GOC:jl") "A homeostatic process in which an organism modulates its internal body temperature.") +AnnotationAssertion( "Wikipedia:Thermoregulation") AnnotationAssertion(rdfs:label "temperature homeostasis") SubClassOf( ) # Class: (response to hypoxia) +AnnotationAssertion(Annotation( "GOC:hjd") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.") +AnnotationAssertion(rdfs:comment "Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.") AnnotationAssertion(rdfs:label "response to hypoxia") SubClassOf( ) SubClassOf( ) # Class: (ameboidal-type cell migration) +AnnotationAssertion(Annotation( "GOC:dph") "Cell migration that is accomplished by extension and retraction of a pseudopodium.") +AnnotationAssertion(rdfs:comment "Note that this term refers to a mode of migration rather than to any particular cell type.") AnnotationAssertion(rdfs:label "ameboidal-type cell migration") SubClassOf( ) # Class: (female germ cell nucleus) +AnnotationAssertion(Annotation( "CL:0000021") Annotation( "GOC:hjd") "The nucleus of the female germ cell, a reproductive cell in females.") AnnotationAssertion(rdfs:label "female germ cell nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9818,13 +12726,21 @@ SubClassOf( ObjectAllValuesFrom( (formation of translation initiation ternary complex) +AnnotationAssertion(Annotation( "GOC:hjd") "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).") AnnotationAssertion(rdfs:label "formation of translation initiation ternary complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (intracellular glucose homeostasis) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "A homeostatic process involved in the maintenance of a steady state level of glucose within a cell.") +AnnotationAssertion(rdfs:label "intracellular glucose homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (gastric acid secretion) +AnnotationAssertion(Annotation( "GOC:hjd") "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.") AnnotationAssertion(rdfs:label "gastric acid secretion") SubClassOf( ) SubClassOf( ) @@ -9832,6 +12748,7 @@ SubClassOf( (embryonic development via the syncytial blastoderm) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.") AnnotationAssertion(rdfs:label "embryonic development via the syncytial blastoderm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -9839,6 +12756,7 @@ SubClassOf( ObjectAllValuesFrom( (in utero embryonic development) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.") AnnotationAssertion(rdfs:label "in utero embryonic development") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -9846,6 +12764,7 @@ SubClassOf( ObjectAllValuesFrom( (formation of primary germ layer) +AnnotationAssertion(Annotation( "GOC:go_curators") "The formation of the ectoderm, mesoderm and endoderm during gastrulation.") AnnotationAssertion(rdfs:label "formation of primary germ layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9854,6 +12773,7 @@ SubClassOf( ObjectSomeValuesFrom( (ectoderm formation) +AnnotationAssertion(Annotation( "GOC:go_curators") "The formation of ectoderm during gastrulation.") AnnotationAssertion(rdfs:label "ectoderm formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9861,6 +12781,7 @@ SubClassOf( ObjectSomeValuesFrom( (endoderm formation) +AnnotationAssertion(Annotation( "GOC:go_curators") "The formation of the endoderm during gastrulation.") AnnotationAssertion(rdfs:label "endoderm formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9868,6 +12789,7 @@ SubClassOf( ObjectSomeValuesFrom( (mesoderm formation) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.") AnnotationAssertion(rdfs:label "mesoderm formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9875,6 +12797,7 @@ SubClassOf( ObjectSomeValuesFrom( (lens placode formation) +AnnotationAssertion(Annotation( "GOC:dph") "The initial developmental process that will lead to the formation of an eye.") AnnotationAssertion(rdfs:label "lens placode formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9882,6 +12805,7 @@ SubClassOf( ObjectSomeValuesFrom( (compound eye morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_sensu") "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.") AnnotationAssertion(rdfs:label "compound eye morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9891,6 +12815,7 @@ SubClassOf( ObjectAllValuesFrom( (compound eye photoreceptor cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.") AnnotationAssertion(rdfs:label "compound eye photoreceptor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9898,6 +12823,7 @@ SubClassOf( ObjectSomeValuesFrom( (eye photoreceptor cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.") AnnotationAssertion(rdfs:label "eye photoreceptor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9905,6 +12831,7 @@ SubClassOf( ObjectSomeValuesFrom( (neural crest cell migration) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") Annotation( "ISBN:0878932437") "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.") AnnotationAssertion(rdfs:label "neural crest cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9913,6 +12840,8 @@ SubClassOf( ObjectSomeValuesFrom( (somitogenesis) +AnnotationAssertion(Annotation( "ISBN:0721662544") "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.") +AnnotationAssertion( "Wikipedia:Somitogenesis") AnnotationAssertion(rdfs:label "somitogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9923,6 +12852,7 @@ SubClassOf( ObjectSomeValuesFrom( (morphogenesis of a branching structure) +AnnotationAssertion(Annotation( "ISBN:0721662544") "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.") AnnotationAssertion(rdfs:label "morphogenesis of a branching structure") SubClassOf( ) SubClassOf( ) @@ -9930,6 +12860,9 @@ SubClassOf( (neuron migration) +AnnotationAssertion(Annotation( "CL:0000540") Annotation( "GOC:go_curators") "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.") +AnnotationAssertion( "Wikipedia:Neural_development#Neuron_migration") +AnnotationAssertion( "Wikipedia:Neuron_migration") AnnotationAssertion(rdfs:label "neuron migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9937,6 +12870,7 @@ SubClassOf( ObjectSomeValuesFrom( (establishment of lymphocyte polarity) +AnnotationAssertion(Annotation( "GOC:mgi_curators") Annotation( "PMID:11244041") Annotation( "PMID:12615889") "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.") AnnotationAssertion(rdfs:label "establishment of lymphocyte polarity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9944,6 +12878,7 @@ SubClassOf( ObjectSomeValuesFrom( (establishment of T cell polarity) +AnnotationAssertion(Annotation( "GOC:mgi_curators") Annotation( "PMID:11244041") Annotation( "PMID:12615889") "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.") AnnotationAssertion(rdfs:label "establishment of T cell polarity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9951,12 +12886,14 @@ SubClassOf( ObjectSomeValuesFrom( (myeloid dendritic cell activation) +AnnotationAssertion(Annotation( "GOC:mgi_curators") Annotation( "ISBN:0781735149") "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.") AnnotationAssertion(rdfs:label "myeloid dendritic cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cell activation) +AnnotationAssertion(Annotation( "GOC:mgi_curators") "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell.") AnnotationAssertion(rdfs:label "cell activation") SubClassOf( ) SubClassOf( ) @@ -9965,6 +12902,8 @@ SubClassOf( ObjectAllValuesFrom( (leukocyte homeostasis) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.") AnnotationAssertion(rdfs:label "leukocyte homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9974,6 +12913,7 @@ SubClassOf( ObjectAllValuesFrom( (T cell homeostatic proliferation) +AnnotationAssertion(Annotation( "GOC:mgi_curators") Annotation( "ISBN:0781735149") "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.") AnnotationAssertion(rdfs:label "T cell homeostatic proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -9981,12 +12921,15 @@ SubClassOf( ObjectSomeValuesFrom( (cytokine production) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.") AnnotationAssertion(rdfs:label "cytokine production") SubClassOf( ) SubClassOf( ) # Class: (regulation of cytokine production) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "Any process that modulates the frequency, rate, or extent of production of a cytokine.") AnnotationAssertion(rdfs:label "regulation of cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -9998,16 +12941,19 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (negative regulation of cytokine production) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "Any process that stops, prevents, or reduces the rate of production of a cytokine.") AnnotationAssertion(rdfs:label "negative regulation of cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cytokine production) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "Any process that activates or increases the frequency, rate or extent of production of a cytokine.") AnnotationAssertion(rdfs:label "positive regulation of cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (serotonin secretion) +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "ISBN:0198506732") Annotation( "ISBN:0781735149") "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.") AnnotationAssertion(rdfs:label "serotonin secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10016,6 +12962,8 @@ SubClassOf( (blastocyst development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0124020607") Annotation( "ISBN:0198542771") "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.") +AnnotationAssertion(rdfs:comment "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'.") AnnotationAssertion(rdfs:label "blastocyst development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10026,6 +12974,8 @@ SubClassOf( ObjectAllValuesFrom( (blastocyst formation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0124020607") Annotation( "ISBN:0198542771") "The initial formation of a blastocyst from a solid ball of cells known as a morula.") +AnnotationAssertion(rdfs:comment "See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'.") AnnotationAssertion(rdfs:label "blastocyst formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10034,6 +12984,8 @@ SubClassOf( ObjectSomeValuesFrom( (inner cell mass cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0124020607") Annotation( "ISBN:0198542771") "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.") +AnnotationAssertion(rdfs:comment "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'.") AnnotationAssertion(rdfs:label "inner cell mass cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10041,6 +12993,8 @@ SubClassOf( ObjectSomeValuesFrom( (trophectodermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0124020607") Annotation( "ISBN:0198542771") "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.") +AnnotationAssertion(rdfs:comment "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.") AnnotationAssertion(rdfs:label "trophectodermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10048,6 +13002,8 @@ SubClassOf( ObjectSomeValuesFrom( (trophectodermal cellular morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0124020607") Annotation( "ISBN:0198542771") "The morphogenesis of trophectoderm cells.") +AnnotationAssertion(rdfs:comment "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.") AnnotationAssertion(rdfs:label "trophectodermal cellular morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10056,6 +13012,8 @@ SubClassOf( ObjectSomeValuesFrom( (blastocyst growth) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0124020607") Annotation( "ISBN:0198542771") "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.") +AnnotationAssertion(rdfs:comment "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'.") AnnotationAssertion(rdfs:label "blastocyst growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10063,6 +13021,8 @@ SubClassOf( ObjectSomeValuesFrom( (inner cell mass cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") Annotation( "ISBN:0124020607") Annotation( "ISBN:0198542771") "The proliferation of cells in the inner cell mass.") +AnnotationAssertion(rdfs:comment "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.") AnnotationAssertion(rdfs:label "inner cell mass cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10070,6 +13030,8 @@ SubClassOf( ObjectSomeValuesFrom( (trophectodermal cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0124020607") Annotation( "ISBN:0198542771") "The proliferation of cells in the trophectoderm.") +AnnotationAssertion(rdfs:comment "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.") AnnotationAssertion(rdfs:label "trophectodermal cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10077,6 +13039,7 @@ SubClassOf( ObjectSomeValuesFrom( (epithelial to mesenchymal transition) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:14701881") "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.") AnnotationAssertion(rdfs:label "epithelial to mesenchymal transition") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10084,12 +13047,14 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic epithelial tube formation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0824072820") "The morphogenesis of an embryonic epithelium into a tube-shaped structure.") AnnotationAssertion(rdfs:label "embryonic epithelial tube formation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (neural plate morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0878932437") "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.") AnnotationAssertion(rdfs:label "neural plate morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10097,6 +13062,7 @@ SubClassOf( ObjectSomeValuesFrom( (neural plate development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:ef") Annotation( "ISBN:0878932437") Annotation( "ISBN:0878932585") "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.") AnnotationAssertion(rdfs:label "neural plate development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10104,6 +13070,8 @@ SubClassOf( ObjectSomeValuesFrom( (neural tube formation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0878932437") "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.") +AnnotationAssertion( "Wikipedia:Neurulation") AnnotationAssertion(rdfs:label "neural tube formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10111,6 +13079,7 @@ SubClassOf( ObjectSomeValuesFrom( (neural fold formation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0878932437") "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.") AnnotationAssertion(rdfs:label "neural fold formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10119,12 +13088,15 @@ SubClassOf( ObjectSomeValuesFrom( (response to yeast) +AnnotationAssertion(Annotation( "PMID:14707091") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.") +AnnotationAssertion(rdfs:comment "defined as response to Saccharomycotina (true yeasts). This excludes fission yeast.") AnnotationAssertion(rdfs:label "response to yeast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (endothelial cell development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of an endothelial cell over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "endothelial cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10133,40 +13105,56 @@ SubClassOf( ObjectSomeValuesFrom( (endothelial cell morphogenesis) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.") AnnotationAssertion(rdfs:label "endothelial cell morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (liver development) + +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:068340007X") "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.") +AnnotationAssertion(rdfs:label "liver development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (tissue homeostasis) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:isa_complete") "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.") AnnotationAssertion(rdfs:label "tissue homeostasis") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (endothelial cell proliferation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.") AnnotationAssertion(rdfs:label "endothelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of endothelial cell proliferation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.") AnnotationAssertion(rdfs:label "regulation of endothelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of endothelial cell proliferation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of endothelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of endothelial cell proliferation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the rate or extent of endothelial cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of endothelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (vasculature development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "UBERON:0002409") "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.") AnnotationAssertion(rdfs:label "vasculature development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10174,6 +13162,7 @@ SubClassOf( ObjectSomeValuesFrom( (blood vessel maturation) +AnnotationAssertion(Annotation( "GOC:dph") "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.") AnnotationAssertion(rdfs:label "blood vessel maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10181,11 +13170,15 @@ SubClassOf( ObjectSomeValuesFrom( (intramembranous ossification) +AnnotationAssertion(Annotation( "ISBN:0878932437") "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.") +AnnotationAssertion( "Wikipedia:Intramembranous_ossification") +AnnotationAssertion(rdfs:comment "An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.") AnnotationAssertion(rdfs:label "intramembranous ossification") SubClassOf( ) # Class: (morphogenesis of an epithelium) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:tb") Annotation( "ISBN:0198506732") "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.") AnnotationAssertion(rdfs:label "morphogenesis of an epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10193,23 +13186,27 @@ SubClassOf( ObjectSomeValuesFrom( (morphogenesis of an epithelial sheet) +AnnotationAssertion(Annotation( "GOC:jl") "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.") AnnotationAssertion(rdfs:label "morphogenesis of an epithelial sheet") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of heart rate) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") Annotation( "PMID:10358008") "Any process that modulates the frequency or rate of heart contraction.") AnnotationAssertion(rdfs:label "regulation of heart rate") SubClassOf( ) # Class: (positive regulation of neuroblast proliferation) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that activates or increases the rate of neuroblast proliferation.") AnnotationAssertion(rdfs:label "positive regulation of neuroblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of mesenchymal cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.") AnnotationAssertion(rdfs:label "positive regulation of mesenchymal cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10217,6 +13214,7 @@ SubClassOf( (chondrocyte differentiation) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.") AnnotationAssertion(rdfs:label "chondrocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10224,6 +13222,7 @@ SubClassOf( ObjectSomeValuesFrom( (chondrocyte development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.") AnnotationAssertion(rdfs:label "chondrocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10231,6 +13230,7 @@ SubClassOf( ObjectSomeValuesFrom( (epithelial cell development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.") AnnotationAssertion(rdfs:label "epithelial cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10238,12 +13238,14 @@ SubClassOf( ObjectSomeValuesFrom( (columnar/cuboidal epithelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.") AnnotationAssertion(rdfs:label "columnar/cuboidal epithelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (columnar/cuboidal epithelial cell development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.") AnnotationAssertion(rdfs:label "columnar/cuboidal epithelial cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10251,12 +13253,14 @@ SubClassOf( ObjectSomeValuesFrom( (glandular epithelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.") AnnotationAssertion(rdfs:label "glandular epithelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (glandular epithelial cell development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.") AnnotationAssertion(rdfs:label "glandular epithelial cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10264,6 +13268,7 @@ SubClassOf( ObjectSomeValuesFrom( (columnar/cuboidal epithelial cell maturation) +AnnotationAssertion(Annotation( "GOC:dph") "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.") AnnotationAssertion(rdfs:label "columnar/cuboidal epithelial cell maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10271,6 +13276,7 @@ SubClassOf( ObjectSomeValuesFrom( (epithelial cell maturation) +AnnotationAssertion(Annotation( "GOC:dph") "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.") AnnotationAssertion(rdfs:label "epithelial cell maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10278,6 +13284,7 @@ SubClassOf( ObjectSomeValuesFrom( (glandular epithelial cell maturation) +AnnotationAssertion(Annotation( "GOC:dph") "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.") AnnotationAssertion(rdfs:label "glandular epithelial cell maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10285,6 +13292,7 @@ SubClassOf( ObjectSomeValuesFrom( (optic cup morphogenesis involved in camera-type eye development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_sensu") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") Annotation( "ISBN:0878932437") "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.") AnnotationAssertion(rdfs:label "optic cup morphogenesis involved in camera-type eye development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10292,6 +13300,7 @@ SubClassOf( ObjectSomeValuesFrom( (inhibition of neuroepithelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:16678814") "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.") AnnotationAssertion(rdfs:label "inhibition of neuroepithelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10300,12 +13309,14 @@ SubClassOf( (regulation of respiratory gaseous exchange by nervous system process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") Annotation( "PMID:12458206") "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.") AnnotationAssertion(rdfs:label "regulation of respiratory gaseous exchange by nervous system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lens development in camera-type eye) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0582064333") "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.") AnnotationAssertion(rdfs:label "lens development in camera-type eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10314,6 +13325,7 @@ SubClassOf( ObjectSomeValuesFrom( (lens morphogenesis in camera-type eye) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_sensu") "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.") AnnotationAssertion(rdfs:label "lens morphogenesis in camera-type eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10323,27 +13335,32 @@ SubClassOf( ObjectSomeValuesFrom( (osteoclast proliferation) +AnnotationAssertion(Annotation( "CL:0000092") Annotation( "GOC:hjd") "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.") AnnotationAssertion(rdfs:label "osteoclast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (defense response to insect) +AnnotationAssertion(Annotation( "GOC:add") "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.") AnnotationAssertion(rdfs:label "defense response to insect") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (leukocyte chemotaxis involved in inflammatory response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.") AnnotationAssertion(rdfs:label "leukocyte chemotaxis involved in inflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (leukocyte chemotaxis involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The movement of an immune cell in response to an external stimulus a part of an immune response.") AnnotationAssertion(rdfs:label "leukocyte chemotaxis involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (hematopoietic progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:rl") Annotation( "ISBN:0781735149") Annotation( "PMID:16551251") "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.") AnnotationAssertion(rdfs:label "hematopoietic progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10351,24 +13368,35 @@ SubClassOf( ObjectSomeValuesFrom( (adaptive immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).") +AnnotationAssertion( "Wikipedia:Adaptive_immune_system") AnnotationAssertion(rdfs:label "adaptive immune response") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectAllValuesFrom( )) +# Class: (organ or tissue specific immune response) + +AnnotationAssertion(Annotation( "GOC:jal") Annotation( "GO_REF:0000022") "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.") +AnnotationAssertion(rdfs:label "organ or tissue specific immune response") +SubClassOf( ) + # Class: (immune effector process) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation.") AnnotationAssertion(rdfs:label "immune effector process") SubClassOf( ) # Class: (lymphocyte homeostasis) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:15826826") Annotation( "PMID:16319493") Annotation( "PMID:16551252") Annotation( "PMID:16551262") "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.") AnnotationAssertion(rdfs:label "lymphocyte homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myeloid cell homeostasis) +AnnotationAssertion(Annotation( "CL:0000763") Annotation( "GOC:add") "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.") AnnotationAssertion(rdfs:label "myeloid cell homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10376,58 +13404,68 @@ SubClassOf( (cell activation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.") AnnotationAssertion(rdfs:label "cell activation involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (endothelial cell activation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.") AnnotationAssertion(rdfs:label "endothelial cell activation involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (leukocyte activation involved in inflammatory response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.") AnnotationAssertion(rdfs:label "leukocyte activation involved in inflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myeloid leukocyte activation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.") AnnotationAssertion(rdfs:label "myeloid leukocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myeloid cell activation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.") AnnotationAssertion(rdfs:label "myeloid cell activation involved in immune response") SubClassOf( ) SubClassOf( ) # Class: (myeloid dendritic cell activation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.") AnnotationAssertion(rdfs:label "myeloid dendritic cell activation involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (monocyte activation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:16551245") "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.") AnnotationAssertion(rdfs:label "monocyte activation involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (macrophage activation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.") AnnotationAssertion(rdfs:label "macrophage activation involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (myeloid dendritic cell differentiation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response.") AnnotationAssertion(rdfs:label "myeloid dendritic cell differentiation involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (lymphocyte activation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.") AnnotationAssertion(rdfs:label "lymphocyte activation involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10435,6 +13473,7 @@ SubClassOf( (T cell activation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.") AnnotationAssertion(rdfs:label "T cell activation involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10442,6 +13481,8 @@ SubClassOf( (T cell differentiation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.") +AnnotationAssertion(rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.") AnnotationAssertion(rdfs:label "T cell differentiation involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10449,40 +13490,49 @@ SubClassOf( (T cell proliferation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The expansion of a T cell population by cell division as part of an immune response.") AnnotationAssertion(rdfs:label "T cell proliferation involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (myeloid progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:16551264") "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.") AnnotationAssertion(rdfs:label "myeloid progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lymphoid progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:16551251") Annotation( "PMID:16551264") "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.") AnnotationAssertion(rdfs:label "lymphoid progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (serotonin production involved in inflammatory response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:16730260") "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.") AnnotationAssertion(rdfs:label "serotonin production involved in inflammatory response") SubClassOf( ) # Class: (leukocyte activation involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.") AnnotationAssertion(rdfs:label "leukocyte activation involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cytokine production involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.") AnnotationAssertion(rdfs:label "cytokine production involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (T cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "Any process that contributes to cytokine production by a T cell.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.") AnnotationAssertion(rdfs:label "T cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10490,12 +13540,16 @@ SubClassOf( (dendritic cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "Any process that contributes to cytokine production by a dendritic cell.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.") AnnotationAssertion(rdfs:label "dendritic cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myeloid dendritic cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "Any process that contributes to cytokine production by a myeloid dendritic cell.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.") AnnotationAssertion(rdfs:label "myeloid dendritic cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10503,25 +13557,40 @@ SubClassOf( (immune system process) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.") +AnnotationAssertion( "Wikipedia:Immune_system") +AnnotationAssertion(rdfs:comment "Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).") AnnotationAssertion(rdfs:label "immune system process") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( ObjectComplementOf())) DisjointClasses( ObjectSomeValuesFrom( )) +# Class: (hepatic immune response) + +AnnotationAssertion(Annotation( "GOC:jal") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "An immune response taking place in the liver.") +AnnotationAssertion(rdfs:label "hepatic immune response") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) + # Class: (MHC protein complex assembly) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:15771591") Annotation( "PMID:15928678") "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.") AnnotationAssertion(rdfs:label "MHC protein complex assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (MHC class II protein complex assembly) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:15771591") "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.") AnnotationAssertion(rdfs:label "MHC class II protein complex assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (dendritic cell chemotaxis) +AnnotationAssertion(Annotation( "CL:0000451") Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:15814331") Annotation( "PMID:16056255") "The movement of a dendritic cell in response to an external stimulus.") AnnotationAssertion(rdfs:label "dendritic cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10529,18 +13598,22 @@ SubClassOf( (myeloid dendritic cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:15814331") Annotation( "PMID:16056255") "The movement of a myeloid dendritic cell in response to an external stimulus.") AnnotationAssertion(rdfs:label "myeloid dendritic cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (production of molecular mediator of immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.") AnnotationAssertion(rdfs:label "production of molecular mediator of immune response") SubClassOf( ) SubClassOf( ) # Class: (serotonin secretion involved in inflammatory response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The regulated release of serotonin by a cell as part of an inflammatory response.") AnnotationAssertion(rdfs:label "serotonin secretion involved in inflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10548,6 +13621,7 @@ SubClassOf( ObjectSomeValuesFrom( (leukocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "Any process involved in the carrying out of an immune response by a leukocyte.") AnnotationAssertion(rdfs:label "leukocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10556,18 +13630,21 @@ SubClassOf( ObjectAllValuesFrom( (myeloid leukocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "Any process involved in the carrying out of an immune response by a myeloid leukocyte.") AnnotationAssertion(rdfs:label "myeloid leukocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lymphocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "Any process involved in the carrying out of an immune response by a lymphocyte.") AnnotationAssertion(rdfs:label "lymphocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (T cell mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "Any process involved in the carrying out of an immune response by a T cell.") AnnotationAssertion(rdfs:label "T cell mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10575,6 +13652,7 @@ SubClassOf( (T cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:11417857") Annotation( "PMID:15120183") "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.") AnnotationAssertion(rdfs:label "T cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10582,40 +13660,47 @@ SubClassOf( ObjectSomeValuesFrom( (adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_sensu") Annotation( "ISBN:0781735149") Annotation( "ISBN:1405196831") "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.") AnnotationAssertion(rdfs:label "adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains") SubClassOf( ) # Class: (dendritic cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:15771591") "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.") AnnotationAssertion(rdfs:label "dendritic cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myeloid dendritic cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:15771591") "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.") AnnotationAssertion(rdfs:label "myeloid dendritic cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (monocyte antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:11200054") "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.") AnnotationAssertion(rdfs:label "monocyte antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (macrophage antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:15771591") "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.") AnnotationAssertion(rdfs:label "macrophage antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (antigen processing and presentation of peptide or polysaccharide antigen via MHC class II) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:15531770") Annotation( "PMID:15771591") Annotation( "PMID:16153240") "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.") AnnotationAssertion(rdfs:label "antigen processing and presentation of peptide or polysaccharide antigen via MHC class II") SubClassOf( ) # Class: (immune system development) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:dph") "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.") AnnotationAssertion(rdfs:label "immune system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10623,6 +13708,7 @@ SubClassOf( (leukocyte differentiation) +AnnotationAssertion(Annotation( "CL:0000738") Annotation( "GOC:add") Annotation( "PMID:16551264") "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.") AnnotationAssertion(rdfs:label "leukocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10630,35 +13716,41 @@ SubClassOf( ObjectSomeValuesFrom( (leukocyte migration involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:14680625") Annotation( "PMID:14708592") Annotation( "PMID:7507411") Annotation( "PMID:8600538") "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response.") AnnotationAssertion(rdfs:label "leukocyte migration involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (leukocyte migration involved in inflammatory response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:14680625") Annotation( "PMID:14708592") Annotation( "PMID:7507411") Annotation( "PMID:8600538") "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.") AnnotationAssertion(rdfs:label "leukocyte migration involved in inflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (production of molecular mediator involved in inflammatory response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:dph") Annotation( "GOC:tb") Annotation( "ISBN:0781735149") "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.") AnnotationAssertion(rdfs:label "production of molecular mediator involved in inflammatory response") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cytokine production involved in inflammatory response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.") AnnotationAssertion(rdfs:label "cytokine production involved in inflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (monocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:11696603") Annotation( "PMID:15173832") "The movement of a monocyte in response to an external stimulus.") AnnotationAssertion(rdfs:label "monocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (pro-T cell differentiation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.") AnnotationAssertion(rdfs:label "pro-T cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10666,6 +13758,7 @@ SubClassOf( ObjectSomeValuesFrom( (myeloid leukocyte differentiation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:16551251") "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.") AnnotationAssertion(rdfs:label "myeloid leukocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10673,120 +13766,143 @@ SubClassOf( (regulation of antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of antigen processing and presentation.") AnnotationAssertion(rdfs:label "regulation of antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.") AnnotationAssertion(rdfs:label "negative regulation of antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation.") AnnotationAssertion(rdfs:label "positive regulation of antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.") AnnotationAssertion(rdfs:label "regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.") AnnotationAssertion(rdfs:label "negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.") AnnotationAssertion(rdfs:label "positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of dendritic cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation.") AnnotationAssertion(rdfs:label "regulation of dendritic cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of dendritic cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.") AnnotationAssertion(rdfs:label "negative regulation of dendritic cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of dendritic cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.") AnnotationAssertion(rdfs:label "positive regulation of dendritic cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of myeloid dendritic cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.") AnnotationAssertion(rdfs:label "regulation of myeloid dendritic cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myeloid dendritic cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.") AnnotationAssertion(rdfs:label "negative regulation of myeloid dendritic cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myeloid dendritic cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.") AnnotationAssertion(rdfs:label "positive regulation of myeloid dendritic cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of monocyte antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation.") AnnotationAssertion(rdfs:label "regulation of monocyte antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of monocyte antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation.") AnnotationAssertion(rdfs:label "negative regulation of monocyte antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of monocyte antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation.") AnnotationAssertion(rdfs:label "positive regulation of monocyte antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of macrophage antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation.") AnnotationAssertion(rdfs:label "regulation of macrophage antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of macrophage antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.") AnnotationAssertion(rdfs:label "negative regulation of macrophage antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of macrophage antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation.") AnnotationAssertion(rdfs:label "positive regulation of macrophage antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of T cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation.") AnnotationAssertion(rdfs:label "regulation of T cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of T cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation.") AnnotationAssertion(rdfs:label "negative regulation of T cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of T cell antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation.") AnnotationAssertion(rdfs:label "positive regulation of T cell antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of immune system process) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of an immune system process.") AnnotationAssertion(rdfs:label "regulation of immune system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of immune system process) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.") AnnotationAssertion(rdfs:label "negative regulation of immune system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10794,6 +13910,7 @@ SubClassOf( (positive regulation of immune system process) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of an immune system process.") AnnotationAssertion(rdfs:label "positive regulation of immune system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10801,36 +13918,43 @@ SubClassOf( (regulation of leukocyte migration) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of leukocyte migration.") AnnotationAssertion(rdfs:label "regulation of leukocyte migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of leukocyte migration) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.") AnnotationAssertion(rdfs:label "negative regulation of leukocyte migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of leukocyte migration) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of leukocyte migration.") AnnotationAssertion(rdfs:label "positive regulation of leukocyte migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of leukocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis.") AnnotationAssertion(rdfs:label "regulation of leukocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of leukocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.") AnnotationAssertion(rdfs:label "negative regulation of leukocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of leukocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.") AnnotationAssertion(rdfs:label "positive regulation of leukocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of leukocyte activation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of leukocyte activation.") AnnotationAssertion(rdfs:label "regulation of leukocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10838,6 +13962,7 @@ SubClassOf( (negative regulation of leukocyte activation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.") AnnotationAssertion(rdfs:label "negative regulation of leukocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10846,6 +13971,7 @@ SubClassOf( (positive regulation of leukocyte activation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of leukocyte activation.") AnnotationAssertion(rdfs:label "positive regulation of leukocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10854,12 +13980,14 @@ SubClassOf( (regulation of immune effector process) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of an immune effector process.") AnnotationAssertion(rdfs:label "regulation of immune effector process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of immune effector process) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.") AnnotationAssertion(rdfs:label "negative regulation of immune effector process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10867,6 +13995,7 @@ SubClassOf( (positive regulation of immune effector process) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of an immune effector process.") AnnotationAssertion(rdfs:label "positive regulation of immune effector process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10874,12 +14003,14 @@ SubClassOf( (regulation of production of molecular mediator of immune response) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.") AnnotationAssertion(rdfs:label "regulation of production of molecular mediator of immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of production of molecular mediator of immune response) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response.") AnnotationAssertion(rdfs:label "negative regulation of production of molecular mediator of immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10887,6 +14018,7 @@ SubClassOf( (positive regulation of production of molecular mediator of immune response) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response.") AnnotationAssertion(rdfs:label "positive regulation of production of molecular mediator of immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -10894,126 +14026,151 @@ SubClassOf( (regulation of leukocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.") AnnotationAssertion(rdfs:label "regulation of leukocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of leukocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.") AnnotationAssertion(rdfs:label "negative regulation of leukocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of leukocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.") AnnotationAssertion(rdfs:label "positive regulation of leukocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of lymphocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.") AnnotationAssertion(rdfs:label "regulation of lymphocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of lymphocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.") AnnotationAssertion(rdfs:label "negative regulation of lymphocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of lymphocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.") AnnotationAssertion(rdfs:label "positive regulation of lymphocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of T cell mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of T cell mediated immunity.") AnnotationAssertion(rdfs:label "regulation of T cell mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of T cell mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.") AnnotationAssertion(rdfs:label "negative regulation of T cell mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of T cell mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.") AnnotationAssertion(rdfs:label "positive regulation of T cell mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cytokine production involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.") AnnotationAssertion(rdfs:label "regulation of cytokine production involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cytokine production involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.") AnnotationAssertion(rdfs:label "negative regulation of cytokine production involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cytokine production involved in immune response) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.") AnnotationAssertion(rdfs:label "positive regulation of cytokine production involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of T cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of T cell cytokine production.") AnnotationAssertion(rdfs:label "regulation of T cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of T cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.") AnnotationAssertion(rdfs:label "negative regulation of T cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of T cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.") AnnotationAssertion(rdfs:label "positive regulation of T cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of dendritic cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.") AnnotationAssertion(rdfs:label "regulation of dendritic cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of dendritic cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.") AnnotationAssertion(rdfs:label "negative regulation of dendritic cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of dendritic cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production.") AnnotationAssertion(rdfs:label "positive regulation of dendritic cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of myeloid dendritic cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production.") AnnotationAssertion(rdfs:label "regulation of myeloid dendritic cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myeloid dendritic cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production.") AnnotationAssertion(rdfs:label "negative regulation of myeloid dendritic cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myeloid dendritic cell cytokine production) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.") AnnotationAssertion(rdfs:label "positive regulation of myeloid dendritic cell cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of myeloid leukocyte differentiation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.") AnnotationAssertion(rdfs:label "regulation of myeloid leukocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myeloid leukocyte differentiation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.") AnnotationAssertion(rdfs:label "negative regulation of myeloid leukocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myeloid leukocyte differentiation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.") AnnotationAssertion(rdfs:label "positive regulation of myeloid leukocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (peptide secretion) +AnnotationAssertion(Annotation( "GOC:add") "The controlled release of a peptide from a cell or a tissue.") AnnotationAssertion(rdfs:label "peptide secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11021,6 +14178,7 @@ SubClassOf( (regulation of peptide secretion) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of peptide secretion.") AnnotationAssertion(rdfs:label "regulation of peptide secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11028,6 +14186,7 @@ SubClassOf( (negative regulation of peptide secretion) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.") AnnotationAssertion(rdfs:label "negative regulation of peptide secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11035,6 +14194,7 @@ SubClassOf( (positive regulation of peptide secretion) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of peptide secretion.") AnnotationAssertion(rdfs:label "positive regulation of peptide secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11042,21 +14202,25 @@ SubClassOf( (regulation of adaptive immune response) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of an adaptive immune response.") AnnotationAssertion(rdfs:label "regulation of adaptive immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of adaptive immune response) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.") AnnotationAssertion(rdfs:label "negative regulation of adaptive immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of adaptive immune response) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.") AnnotationAssertion(rdfs:label "positive regulation of adaptive immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_sensu") "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.") AnnotationAssertion(rdfs:label "regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -11065,46 +14229,58 @@ SubClassOf( ObjectAllValuesFrom( (negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_sensu") "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.") AnnotationAssertion(rdfs:label "negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_sensu") "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.") AnnotationAssertion(rdfs:label "positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of response to biotic stimulus) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "regulation of response to biotic stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of response to biotic stimulus) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "negative regulation of response to biotic stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of response to biotic stimulus) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "positive regulation of response to biotic stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of myeloid leukocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.") AnnotationAssertion(rdfs:label "regulation of myeloid leukocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myeloid leukocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.") AnnotationAssertion(rdfs:label "negative regulation of myeloid leukocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myeloid leukocyte mediated immunity) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.") AnnotationAssertion(rdfs:label "positive regulation of myeloid leukocyte mediated immunity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (tendon sheath development) +AnnotationAssertion(Annotation( "PMID:20696843") "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move.") AnnotationAssertion(rdfs:label "tendon sheath development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11112,11 +14288,13 @@ SubClassOf( ObjectSomeValuesFrom( (regionalization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.") AnnotationAssertion(rdfs:label "regionalization") SubClassOf( ) # Class: (developmental process involved in reproduction) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring.") AnnotationAssertion(rdfs:label "developmental process involved in reproduction") EquivalentClasses( ObjectIntersectionOf( )) SubClassOf( ) @@ -11124,6 +14302,7 @@ SubClassOf( (heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.") AnnotationAssertion(rdfs:label "heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11131,11 +14310,13 @@ SubClassOf( ObjectSomeValuesFrom( (system process) +AnnotationAssertion(Annotation( "GOC:mtg_cardio") "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.") AnnotationAssertion(rdfs:label "system process") SubClassOf( ) # Class: (skeletal muscle contraction) +AnnotationAssertion(Annotation( "GOC:mtg_cardio") Annotation( "GOC:mtg_muscle") "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.") AnnotationAssertion(rdfs:label "skeletal muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11143,43 +14324,58 @@ SubClassOf( ObjectSomeValuesFrom( (muscle system process) +AnnotationAssertion(Annotation( "GOC:mtg_cardio") "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.") AnnotationAssertion(rdfs:label "muscle system process") SubClassOf( ) # Class: (circulatory system process) +AnnotationAssertion(Annotation( "GOC:mtg_cardio") "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.") +AnnotationAssertion( "Wikipedia:Circulatory_system") AnnotationAssertion(rdfs:label "circulatory system process") SubClassOf( ) +# Class: (renal system process) + +AnnotationAssertion(Annotation( "GOC:cjm") Annotation( "GOC:mtg_cardio") Annotation( "GOC:mtg_kidney_jan10") "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).") +AnnotationAssertion(rdfs:label "renal system process") +SubClassOf( ) + # Class: (heart process) +AnnotationAssertion(Annotation( "GOC:mtg_cardio") "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.") AnnotationAssertion(rdfs:label "heart process") SubClassOf( ) # Class: (respiratory system process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_cardio") Annotation( "GOC:tb") "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.") AnnotationAssertion(rdfs:label "respiratory system process") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (detection of oxygen) +AnnotationAssertion(Annotation( "GOC:mtg_cardio") "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal.") AnnotationAssertion(rdfs:label "detection of oxygen") SubClassOf( ) SubClassOf( ) # Class: (mesodermal-endodermal cell signaling) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "Any process that mediates the transfer of information from mesodermal cells to endodermal cells.") AnnotationAssertion(rdfs:label "mesodermal-endodermal cell signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (endodermal-mesodermal cell signaling) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "Any process that mediates the transfer of information from endodermal cells to mesodermal cells.") AnnotationAssertion(rdfs:label "endodermal-mesodermal cell signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (cardiogenic plate morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.") AnnotationAssertion(rdfs:label "cardiogenic plate morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11188,6 +14384,7 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic heart tube morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.") AnnotationAssertion(rdfs:label "embryonic heart tube morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11198,6 +14395,7 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic heart tube formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.") AnnotationAssertion(rdfs:label "embryonic heart tube formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11205,17 +14403,20 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic heart tube formation via epithelial folding) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis.") AnnotationAssertion(rdfs:label "embryonic heart tube formation via epithelial folding") SubClassOf( ) # Class: (neural crest cell migration involved in heart formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.") AnnotationAssertion(rdfs:label "neural crest cell migration involved in heart formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (outflow tract septum morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.") AnnotationAssertion(rdfs:label "outflow tract septum morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11223,6 +14424,7 @@ SubClassOf( ObjectSomeValuesFrom( (membranous septum morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.") AnnotationAssertion(rdfs:label "membranous septum morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11231,6 +14433,7 @@ SubClassOf( ObjectSomeValuesFrom( (muscular septum morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.") AnnotationAssertion(rdfs:label "muscular septum morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11239,6 +14442,7 @@ SubClassOf( ObjectSomeValuesFrom( (outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") Annotation( "UBERON:0004145") "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.") AnnotationAssertion(rdfs:label "outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11247,6 +14451,7 @@ SubClassOf( ObjectSomeValuesFrom( (morphogenesis of an epithelial fold involved in embryonic heart tube formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation.") AnnotationAssertion(rdfs:label "morphogenesis of an epithelial fold involved in embryonic heart tube formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11254,12 +14459,14 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of animal organ formation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.") AnnotationAssertion(rdfs:label "regulation of animal organ formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (endocardium development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.") AnnotationAssertion(rdfs:label "endocardium development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11268,12 +14475,14 @@ SubClassOf( ObjectSomeValuesFrom( (endothelium development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.") AnnotationAssertion(rdfs:label "endothelium development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (morphogenesis of an endothelium) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.") AnnotationAssertion(rdfs:label "morphogenesis of an endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11281,6 +14490,7 @@ SubClassOf( ObjectSomeValuesFrom( (endocardium morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.") AnnotationAssertion(rdfs:label "endocardium morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11289,36 +14499,42 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac conduction system development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.") AnnotationAssertion(rdfs:label "cardiac conduction system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (atrioventricular node development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.") AnnotationAssertion(rdfs:label "atrioventricular node development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (sinoatrial node development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.") AnnotationAssertion(rdfs:label "sinoatrial node development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (His-Purkinje system development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.") AnnotationAssertion(rdfs:label "His-Purkinje system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Purkinje myocyte development) +AnnotationAssertion(Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.") AnnotationAssertion(rdfs:label "Purkinje myocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Purkinje myocyte differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:mtg_heart") "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.") AnnotationAssertion(rdfs:label "Purkinje myocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11326,6 +14542,7 @@ SubClassOf( ObjectSomeValuesFrom( (coronary vein morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of veins of the heart are generated and organized.") AnnotationAssertion(rdfs:label "coronary vein morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11333,6 +14550,7 @@ SubClassOf( (endocardial cushion development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.") AnnotationAssertion(rdfs:label "endocardial cushion development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11340,6 +14558,7 @@ SubClassOf( ObjectSomeValuesFrom( (endocardial cushion morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.") AnnotationAssertion(rdfs:label "endocardial cushion morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11348,6 +14567,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac skeleton development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart.") AnnotationAssertion(rdfs:label "cardiac skeleton development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11355,6 +14575,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac chamber development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.") AnnotationAssertion(rdfs:label "cardiac chamber development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11363,6 +14584,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac chamber morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.") AnnotationAssertion(rdfs:label "cardiac chamber morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11372,6 +14594,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac chamber formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.") AnnotationAssertion(rdfs:label "cardiac chamber formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11380,6 +14603,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac ventricle morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.") AnnotationAssertion(rdfs:label "cardiac ventricle morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11387,6 +14611,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac atrium morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.") AnnotationAssertion(rdfs:label "cardiac atrium morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11394,6 +14619,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac atrium formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.") AnnotationAssertion(rdfs:label "cardiac atrium formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11401,6 +14627,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac ventricle formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.") AnnotationAssertion(rdfs:label "cardiac ventricle formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11408,30 +14635,35 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac left atrium morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the left cardiac atrium is generated and organized.") AnnotationAssertion(rdfs:label "cardiac left atrium morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cardiac right atrium morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the right cardiac atrium is generated and organized.") AnnotationAssertion(rdfs:label "cardiac right atrium morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cardiac left ventricle morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the left cardiac ventricle is generated and organized.") AnnotationAssertion(rdfs:label "cardiac left ventricle morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cardiac right ventricle morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the right cardiac ventricle is generated and organized.") AnnotationAssertion(rdfs:label "cardiac right ventricle morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cardiac left atrium formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts.") AnnotationAssertion(rdfs:label "cardiac left atrium formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11439,6 +14671,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac right atrium formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts.") AnnotationAssertion(rdfs:label "cardiac right atrium formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11446,6 +14679,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac left ventricle formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.") AnnotationAssertion(rdfs:label "cardiac left ventricle formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11453,6 +14687,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac right ventricle formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.") AnnotationAssertion(rdfs:label "cardiac right ventricle formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11460,6 +14695,7 @@ SubClassOf( ObjectSomeValuesFrom( (left ventricular cardiac muscle tissue morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.") AnnotationAssertion(rdfs:label "left ventricular cardiac muscle tissue morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11467,41 +14703,72 @@ SubClassOf( ObjectSomeValuesFrom( (right ventricular cardiac muscle tissue morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.") AnnotationAssertion(rdfs:label "right ventricular cardiac muscle tissue morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (ventricular trabecula myocardium morphogenesis) + +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.") +AnnotationAssertion(rdfs:label "ventricular trabecula myocardium morphogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (left ventricular trabecular myocardium morphogenesis) + +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized.") +AnnotationAssertion(rdfs:label "left ventricular trabecular myocardium morphogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (right ventricular trabecular myocardium morphogenesis) + +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of the right ventricular myocardium are generated and organized.") +AnnotationAssertion(rdfs:label "right ventricular trabecular myocardium morphogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (atrial cardiac muscle tissue development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "atrial cardiac muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (ventricular cardiac muscle tissue development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "ventricular cardiac muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cardiac atrium development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.") AnnotationAssertion(rdfs:label "cardiac atrium development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cardiac ventricle development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.") AnnotationAssertion(rdfs:label "cardiac ventricle development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (sinus venosus development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.") AnnotationAssertion(rdfs:label "sinus venosus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (sinus venosus morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.") AnnotationAssertion(rdfs:label "sinus venosus morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11509,6 +14776,7 @@ SubClassOf( ObjectSomeValuesFrom( (sinus venosus formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.") AnnotationAssertion(rdfs:label "sinus venosus formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11516,6 +14784,7 @@ SubClassOf( ObjectSomeValuesFrom( (growth involved in heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "Developmental growth that contributes to the shaping of the heart.") AnnotationAssertion(rdfs:label "growth involved in heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11523,12 +14792,14 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac muscle tissue growth involved in heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart.") AnnotationAssertion(rdfs:label "cardiac muscle tissue growth involved in heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (heart capillary growth) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle.") AnnotationAssertion(rdfs:label "heart capillary growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11537,12 +14808,14 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac neural crest cell migration involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.") AnnotationAssertion(rdfs:label "cardiac neural crest cell migration involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cardioblast migration) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.") AnnotationAssertion(rdfs:label "cardioblast migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11550,6 +14823,7 @@ SubClassOf( ObjectSomeValuesFrom( (endocardial cushion formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") Annotation( "PMID:15797462") "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.") AnnotationAssertion(rdfs:label "endocardial cushion formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11558,26 +14832,31 @@ SubClassOf( ObjectSomeValuesFrom( (cell migration involved in endocardial cushion formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.") AnnotationAssertion(rdfs:label "cell migration involved in endocardial cushion formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (apoptotic process involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:mtg_heart") "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.") AnnotationAssertion(rdfs:label "apoptotic process involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (apoptotic process involved in endocardial cushion morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:mtg_heart") "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.") AnnotationAssertion(rdfs:label "apoptotic process involved in endocardial cushion morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (apoptotic process involved in heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:mtg_heart") "Any apoptotic process that contributes to the shaping of the heart.") AnnotationAssertion(rdfs:label "apoptotic process involved in heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cardiac septum development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The progression of a cardiac septum over time, from its initial formation to the mature structure.") AnnotationAssertion(rdfs:label "cardiac septum development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11586,6 +14865,7 @@ SubClassOf( ObjectSomeValuesFrom( (ventricular septum development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The progression of the ventricular septum over time from its formation to the mature structure.") AnnotationAssertion(rdfs:label "ventricular septum development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11593,6 +14873,7 @@ SubClassOf( ObjectSomeValuesFrom( (atrial septum development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The progression of the atrial septum over time, from its initial formation to the mature structure.") AnnotationAssertion(rdfs:label "atrial septum development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11600,6 +14881,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac septum cell differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which an endocardial cushion cell becomes a cell of a cardiac septum.") AnnotationAssertion(rdfs:label "cardiac septum cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11607,23 +14889,55 @@ SubClassOf( ObjectSomeValuesFrom( (physiological muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development.") AnnotationAssertion(rdfs:label "physiological muscle hypertrophy") SubClassOf( ) # Class: (cardiac muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.") AnnotationAssertion(rdfs:label "cardiac muscle hypertrophy") SubClassOf( ) # Class: (physiological cardiac muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:mtg_heart") "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart.") AnnotationAssertion(rdfs:label "physiological cardiac muscle hypertrophy") SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (type B pancreatic cell differentiation) + +AnnotationAssertion(Annotation( "CL:0000169") Annotation( "GOC:dph") Annotation( "PMID:11076772") "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.") +AnnotationAssertion(rdfs:label "type B pancreatic cell differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreatic A cell differentiation) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:11076772") "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.") +AnnotationAssertion(rdfs:label "pancreatic A cell differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreatic D cell differentiation) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:11076772") "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.") +AnnotationAssertion(rdfs:label "pancreatic D cell differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreatic PP cell differentiation) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:11076772") "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.") +AnnotationAssertion(rdfs:label "pancreatic PP cell differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (heart rudiment development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.") AnnotationAssertion(rdfs:label "heart rudiment development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11631,6 +14945,7 @@ SubClassOf( ObjectSomeValuesFrom( (heart rudiment morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of the heart rudiment are generated and organized.") AnnotationAssertion(rdfs:label "heart rudiment morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11639,14 +14954,46 @@ SubClassOf( ObjectSomeValuesFrom( (heart rudiment formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The developmental process pertaining to the initial formation of the heart rudiment.") AnnotationAssertion(rdfs:label "heart rudiment formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreatic A cell development) + +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.") +AnnotationAssertion(rdfs:label "pancreatic A cell development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (type B pancreatic cell development) + +AnnotationAssertion(Annotation( "CL:0000169") Annotation( "GOC:dph") "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.") +AnnotationAssertion(rdfs:label "type B pancreatic cell development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreatic D cell development) + +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin.") +AnnotationAssertion(rdfs:label "pancreatic D cell development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreatic PP cell development) + +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.") +AnnotationAssertion(rdfs:label "pancreatic PP cell development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (cilium movement) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") "The directed, self-propelled movement of a cilium.") +AnnotationAssertion(rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent.") AnnotationAssertion(rdfs:label "cilium movement") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -11672,6 +15019,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (proepicardium development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:18722343") "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.") AnnotationAssertion(rdfs:label "proepicardium development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11679,12 +15027,14 @@ SubClassOf( ObjectSomeValuesFrom( (septum transversum development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:18722343") "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme.") AnnotationAssertion(rdfs:label "septum transversum development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (pericardium morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:18722343") "The process in which the anatomical structure of the pericardium is generated and organized.") AnnotationAssertion(rdfs:label "pericardium morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11693,27 +15043,35 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac endothelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:18722343") "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.") AnnotationAssertion(rdfs:label "cardiac endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of cilium movement) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.") +AnnotationAssertion(rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent.") AnnotationAssertion(rdfs:label "regulation of cilium movement") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cilium movement) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.") +AnnotationAssertion(rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent.") AnnotationAssertion(rdfs:label "positive regulation of cilium movement") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cilium movement) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.") +AnnotationAssertion(rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent.") AnnotationAssertion(rdfs:label "negative regulation of cilium movement") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (brainstem development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.") AnnotationAssertion(rdfs:label "brainstem development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11721,6 +15079,7 @@ SubClassOf( (establishment of cell polarity involved in ameboidal cell migration) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.") AnnotationAssertion(rdfs:label "establishment of cell polarity involved in ameboidal cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -11729,28 +15088,33 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell.") AnnotationAssertion(rdfs:label "establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (establishment of cell polarity involved in gastrulation cell migration) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation.") AnnotationAssertion(rdfs:label "establishment of cell polarity involved in gastrulation cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (establishment or maintenance of cytoskeleton polarity involved in gastrulation) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation.") AnnotationAssertion(rdfs:label "establishment or maintenance of cytoskeleton polarity involved in gastrulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (epithelial cell morphogenesis involved in gastrulation) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation.") AnnotationAssertion(rdfs:label "epithelial cell morphogenesis involved in gastrulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (epithelial cell morphogenesis) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.") AnnotationAssertion(rdfs:label "epithelial cell morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11758,6 +15122,7 @@ SubClassOf( ObjectSomeValuesFrom( (optic vesicle formation) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.") AnnotationAssertion(rdfs:label "optic vesicle formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11767,6 +15132,7 @@ SubClassOf( ObjectSomeValuesFrom( (optic vesicle morphogenesis) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.") AnnotationAssertion(rdfs:label "optic vesicle morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11774,6 +15140,7 @@ SubClassOf( ObjectSomeValuesFrom( (neural retina development) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.") AnnotationAssertion(rdfs:label "neural retina development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11782,11 +15149,13 @@ SubClassOf( ObjectSomeValuesFrom( (cell motility involved in camera-type eye morphogenesis) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye.") AnnotationAssertion(rdfs:label "cell motility involved in camera-type eye morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (chondrocyte differentiation involved in endochondral bone morphogenesis) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.") AnnotationAssertion(rdfs:label "chondrocyte differentiation involved in endochondral bone morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11794,35 +15163,127 @@ SubClassOf( ObjectSomeValuesFrom( (chondrocyte morphogenesis involved in endochondral bone morphogenesis) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized.") AnnotationAssertion(rdfs:label "chondrocyte morphogenesis involved in endochondral bone morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (endochondral bone growth) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.") AnnotationAssertion(rdfs:label "endochondral bone growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (chondrocyte development involved in endochondral bone morphogenesis) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.") AnnotationAssertion(rdfs:label "chondrocyte development involved in endochondral bone morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (molecular_function) + +AnnotationAssertion(Annotation( "GOC:pdt") "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.") +AnnotationAssertion(rdfs:comment "Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex.") +AnnotationAssertion(rdfs:label "molecular_function") +SubClassOf( ) +DisjointClasses( ) +DisjointClasses( ) + +# Class: (catalytic activity) + +AnnotationAssertion(Annotation( "GOC:vw") Annotation( "ISBN:0198506732") "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.") +AnnotationAssertion( "Wikipedia:Enzyme") +AnnotationAssertion(rdfs:label "catalytic activity") +SubClassOf( ) + +# Class: (nuclease activity) + +AnnotationAssertion(Annotation( "ISBN:0198547684") "Catalysis of the hydrolysis of ester linkages within nucleic acids.") +AnnotationAssertion(rdfs:comment "Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.") +AnnotationAssertion(rdfs:label "nuclease activity") +SubClassOf( ) + +# Class: (DNA nuclease activity) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198547684") "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.") +AnnotationAssertion(Annotation(rdfs:label "Cleavage of DNA by DFF40") "Reactome:R-HSA-211247") +AnnotationAssertion(Annotation(rdfs:label "Long-range resection of DNA DSBs by EXO1 or DNA2") "Reactome:R-HSA-5685994") +AnnotationAssertion(Annotation(rdfs:label "DNA nucleases unhook the interstrand crosslink (ICL)") "Reactome:R-HSA-6785986") +AnnotationAssertion(rdfs:label "DNA nuclease activity") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (transporter activity) + +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dgf") "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.") +AnnotationAssertion(rdfs:comment "Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.") +AnnotationAssertion(rdfs:label "transporter activity") +SubClassOf( ) + +# Class: (amine transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:mtg_transport") Annotation( "ISBN:0198506732") Annotation( "ISBN:0815340729") "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.") +AnnotationAssertion(rdfs:label "amine transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (lipid transporter activity) + +AnnotationAssertion(Annotation( "GOC:ai") "Enables the directed movement of lipids into, out of or within a cell, or between cells.") +AnnotationAssertion(Annotation(rdfs:label "ABCAs mediate lipid efflux") "Reactome:R-HSA-1369028") +AnnotationAssertion(Annotation(rdfs:label "ABCAs mediate lipid influx") "Reactome:R-HSA-1369052") +AnnotationAssertion(Annotation(rdfs:label "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex") "Reactome:R-HSA-174786") +AnnotationAssertion(Annotation(rdfs:label "ABCA12 transports lipids from cytosol to extracellular region") "Reactome:R-HSA-5682285") +AnnotationAssertion(Annotation(rdfs:label "Defective ABCA12 does not transport lipids from cytosol to extracellular region") "Reactome:R-HSA-5682311") +AnnotationAssertion(Annotation(rdfs:label "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body") "Reactome:R-HSA-5683672") +AnnotationAssertion(Annotation(rdfs:label "ABCA3 transports PC, PG from ER membrane to lamellar body") "Reactome:R-HSA-5683714") +AnnotationAssertion(Annotation(rdfs:label "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body") "Reactome:R-HSA-5688397") +AnnotationAssertion(Annotation(rdfs:label "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane") "Reactome:R-HSA-6801250") +AnnotationAssertion(Annotation(rdfs:label "ABCA5 transports CHOL from lysosomal lumen to cytosol") "Reactome:R-HSA-8848053") +AnnotationAssertion(Annotation(rdfs:label "MTTP lipidates APOB-100, forming a pre-VLDL") "Reactome:R-HSA-8866329") +AnnotationAssertion(rdfs:label "lipid transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (organic acid transmembrane transporter activity) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage.") +AnnotationAssertion(rdfs:label "organic acid transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (glucose transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.") +AnnotationAssertion(Annotation(rdfs:label "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2") "Reactome:R-HSA-499981") +AnnotationAssertion(Annotation(rdfs:label "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen") "Reactome:R-HSA-5653873") +AnnotationAssertion(rdfs:label "glucose transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (cellular_component) +AnnotationAssertion(Annotation( "GOC:pdt") "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).") +AnnotationAssertion( "NIF_Subcellular:sao1337158144") +AnnotationAssertion(rdfs:comment "Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.") AnnotationAssertion(rdfs:label "cellular_component") SubClassOf( ) DisjointClasses( ) # Class: (extracellular region) +AnnotationAssertion(Annotation( "GOC:go_curators") "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.") +AnnotationAssertion( "Wikipedia:Extracellular") +AnnotationAssertion(rdfs:comment "Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.") AnnotationAssertion(rdfs:label "extracellular region") SubClassOf( ) # Class: (fibrinogen complex) +AnnotationAssertion(Annotation( "ISBN:0198547684") "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.") AnnotationAssertion(rdfs:label "fibrinogen complex") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -11830,6 +15291,8 @@ SubClassOf( ObjectSomeValuesFrom( (collagen trimer) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:mah") Annotation( "ISBN:0721639976") Annotation( "PMID:19693541") Annotation( "PMID:21421911") "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.") +AnnotationAssertion( "Wikipedia:Collagen") AnnotationAssertion(rdfs:label "collagen trimer") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -11837,6 +15300,7 @@ SubClassOf( ObjectAllValuesFrom( (fibrillar collagen trimer) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0721639976") Annotation( "PMID:21421911") "Any triple helical collagen trimer that forms fibrils.") AnnotationAssertion(rdfs:label "fibrillar collagen trimer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11846,11 +15310,15 @@ DisjointClasses( (collagen type II trimer) +AnnotationAssertion(Annotation( "ISBN:0721639976") "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils.") +AnnotationAssertion( "Wikipedia:Collagen_type_II") AnnotationAssertion(rdfs:label "collagen type II trimer") SubClassOf( ) # Class: (collagen type IV trimer) +AnnotationAssertion(Annotation( "ISBN:0721639976") Annotation( "PMID:19693541") Annotation( "PMID:21421911") "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.") +AnnotationAssertion( "Wikipedia:Collagen_type_IV") AnnotationAssertion(rdfs:label "collagen type IV trimer") SubClassOf( ) SubClassOf( ) @@ -11860,23 +15328,34 @@ SubClassOf( ObjectSomeValuesFrom( (basement membrane) +AnnotationAssertion(Annotation( "ISBN:0198547684") Annotation( "PMID:22505934") "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.") +AnnotationAssertion( "Wikipedia:Basement_membrane") +AnnotationAssertion(rdfs:comment "Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer.") AnnotationAssertion(rdfs:label "basement membrane") SubClassOf( ) # Class: (extracellular space) +AnnotationAssertion(Annotation( "ISBN:0198547684") "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.") +AnnotationAssertion( "NIF_Subcellular:sao1425028079") +AnnotationAssertion(rdfs:comment "Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.") AnnotationAssertion(rdfs:label "extracellular space") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (intracellular anatomical structure) +AnnotationAssertion(Annotation( "ISBN:0198506732") "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.") +AnnotationAssertion( "Wikipedia:Intracellular") AnnotationAssertion(rdfs:label "intracellular anatomical structure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (nucleus) +AnnotationAssertion(Annotation( "GOC:go_curators") "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.") +AnnotationAssertion( "NIF_Subcellular:sao1702920020") +AnnotationAssertion( "Wikipedia:Cell_nucleus") AnnotationAssertion(rdfs:label "nucleus") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -11886,6 +15365,8 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (nuclear envelope) +AnnotationAssertion(Annotation( "ISBN:0198547684") "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).") +AnnotationAssertion( "Wikipedia:Nuclear_envelope") AnnotationAssertion(rdfs:label "nuclear envelope") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -11893,6 +15374,8 @@ SubClassOf( ObjectSomeValuesFrom( (nuclear outer membrane) +AnnotationAssertion(Annotation( "ISBN:0198547684") "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.") +AnnotationAssertion( "NIF_Subcellular:sao1617136075") AnnotationAssertion(rdfs:label "nuclear outer membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11901,12 +15384,18 @@ SubClassOf( ObjectSomeValuesFrom( (chromosome) +AnnotationAssertion(Annotation( "ISBN:0198547684") "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.") +AnnotationAssertion( "Wikipedia:Chromosome") +AnnotationAssertion(rdfs:comment "Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.") AnnotationAssertion(rdfs:label "chromosome") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (nucleolus) +AnnotationAssertion(Annotation( "ISBN:0198506732") "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.") +AnnotationAssertion( "NIF_Subcellular:sao1820400233") +AnnotationAssertion( "Wikipedia:Nucleolus") AnnotationAssertion(rdfs:label "nucleolus") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -11914,12 +15403,17 @@ SubClassOf( ObjectSomeValuesFrom( (cytoplasm) +AnnotationAssertion(Annotation( "ISBN:0198547684") "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.") +AnnotationAssertion( "Wikipedia:Cytoplasm") AnnotationAssertion(rdfs:label "cytoplasm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (lysosome) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.") +AnnotationAssertion( "NIF_Subcellular:sao585356902") +AnnotationAssertion( "Wikipedia:Lysosome") AnnotationAssertion(rdfs:label "lysosome") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -11928,6 +15422,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (lysosomal membrane) +AnnotationAssertion(Annotation( "GOC:ai") "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.") AnnotationAssertion(rdfs:label "lysosomal membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11938,17 +15433,22 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (primary lysosome) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0815316194") "A lysosome before it has fused with a vesicle or vacuole.") +AnnotationAssertion( "NIF_Subcellular:sao1140587416") AnnotationAssertion(rdfs:label "primary lysosome") SubClassOf( ) # Class: (vacuole) +AnnotationAssertion(Annotation( "GOC:mtg_sensu") Annotation( "ISBN:0198506732") "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.") +AnnotationAssertion( "Wikipedia:Vacuole") AnnotationAssertion(rdfs:label "vacuole") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vacuolar membrane) +AnnotationAssertion(Annotation( "GOC:ai") "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.") AnnotationAssertion(rdfs:label "vacuolar membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -11956,12 +15456,17 @@ SubClassOf( ObjectSomeValuesFrom( (vacuolar lumen) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The volume enclosed within the vacuolar membrane.") AnnotationAssertion(rdfs:label "vacuolar lumen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (Golgi apparatus) +AnnotationAssertion(Annotation( "ISBN:0198506732") "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.") +AnnotationAssertion( "NIF_Subcellular:sao451912436") +AnnotationAssertion( "Wikipedia:Golgi_apparatus") +AnnotationAssertion(rdfs:comment "Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.") AnnotationAssertion(rdfs:label "Golgi apparatus") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -11971,11 +15476,17 @@ SubClassOf( ObjectAllValuesFrom( (Golgi-associated vesicle) +AnnotationAssertion(Annotation( "GOC:mah") "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.") +AnnotationAssertion( "NIF_Subcellular:sao819927218") +AnnotationAssertion(rdfs:comment "Note that this definition includes vesicles that are transiently associated with the Golgi.") AnnotationAssertion(rdfs:label "Golgi-associated vesicle") SubClassOf( ) # Class: (ribosome) +AnnotationAssertion(Annotation( "ISBN:0198506732") "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.") +AnnotationAssertion( "NIF_Subcellular:sao1429207766") +AnnotationAssertion( "Wikipedia:Ribosome") AnnotationAssertion(rdfs:label "ribosome") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -11984,11 +15495,16 @@ SubClassOf( ObjectSomeValuesFrom( (cytoskeleton) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:16959967") Annotation( "PMID:27419875") "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.") +AnnotationAssertion( "Wikipedia:Cytoskeleton") AnnotationAssertion(rdfs:label "cytoskeleton") SubClassOf( ) # Class: (microtubule) +AnnotationAssertion(Annotation( "ISBN:0879693568") "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.") +AnnotationAssertion( "NIF_Subcellular:sao1846835077") +AnnotationAssertion( "Wikipedia:Microtubule") AnnotationAssertion(rdfs:label "microtubule") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -11996,6 +15512,7 @@ SubClassOf( ObjectSomeValuesFrom( (axonemal microtubule) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "ISBN:0815316194") "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.") AnnotationAssertion(rdfs:label "axonemal microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12003,6 +15520,7 @@ SubClassOf( ObjectSomeValuesFrom( (nuclear microtubule) +AnnotationAssertion(Annotation( "GOC:mah") "Any microtubule in the nucleus of a cell.") AnnotationAssertion(rdfs:label "nuclear microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12010,6 +15528,7 @@ SubClassOf( ObjectSomeValuesFrom( (cytoplasmic microtubule) +AnnotationAssertion(Annotation( "GOC:mah") "Any microtubule in the cytoplasm of a cell.") AnnotationAssertion(rdfs:label "cytoplasmic microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12017,6 +15536,10 @@ SubClassOf( ObjectSomeValuesFrom( (actin filament) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") Annotation( "PMID:10666339") "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.") +AnnotationAssertion( "FMA:63850") +AnnotationAssertion( "NIF_Subcellular:sao1588493326") +AnnotationAssertion( "Wikipedia:Actin") AnnotationAssertion(rdfs:label "actin filament") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -12024,12 +15547,19 @@ SubClassOf( ObjectSomeValuesFrom( (plasma membrane) +AnnotationAssertion(Annotation( "ISBN:0716731363") "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.") +AnnotationAssertion( "NIF_Subcellular:sao1663586795") +AnnotationAssertion( "Wikipedia:Cell_membrane") AnnotationAssertion(rdfs:label "plasma membrane") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (microvillus) +AnnotationAssertion(Annotation( "ISBN:0815316194") "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.") +AnnotationAssertion( "NIF_Subcellular:sao671419673") +AnnotationAssertion( "Wikipedia:Microvillus") +AnnotationAssertion(rdfs:comment "Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta.") AnnotationAssertion(rdfs:label "microvillus") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -12040,11 +15570,18 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (cell-cell junction) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "GOC:dgh") Annotation( "GOC:hb") Annotation( "GOC:mah") Annotation( "PMID:21422226") Annotation( "PMID:28096264") "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.") +AnnotationAssertion( "NIF_Subcellular:sao1922892319") AnnotationAssertion(rdfs:label "cell-cell junction") SubClassOf( ) # Class: (cilium) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:curators") Annotation( "GOC:kmv") Annotation( "GOC:vw") Annotation( "ISBN:0198547684") Annotation( "PMID:16824949") Annotation( "PMID:17009929") Annotation( "PMID:20144998") "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.") +AnnotationAssertion( "FMA:67181") +AnnotationAssertion( "NIF_Subcellular:sao787716553") +AnnotationAssertion( "Wikipedia:Cilium") +AnnotationAssertion(rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms.") AnnotationAssertion(rdfs:label "cilium") SubClassOf( ) SubClassOf( ) @@ -12072,6 +15609,9 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (axoneme) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:cilia") Annotation( "ISBN:0198547684") "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.") +AnnotationAssertion( "Wikipedia:Axoneme") +AnnotationAssertion(rdfs:comment "Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane.") AnnotationAssertion(rdfs:label "axoneme") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -12081,54 +15621,187 @@ SubClassOf( ObjectSomeValuesFrom( (cell cortex) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.") +AnnotationAssertion( "Wikipedia:Cell_cortex") AnnotationAssertion(rdfs:label "cell cortex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (carbohydrate metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.") +AnnotationAssertion( "Wikipedia:Carbohydrate_metabolism") AnnotationAssertion(rdfs:label "carbohydrate metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (polysaccharide metabolic process) +AnnotationAssertion(Annotation( "ISBN:0198547684") "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.") AnnotationAssertion(rdfs:label "polysaccharide metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (glycogen metabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.") +AnnotationAssertion(rdfs:label "glycogen metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (glycogen biosynthetic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.") +AnnotationAssertion( "MetaCyc:GLYCOGENSYNTH-PWY") +AnnotationAssertion( "MetaCyc:PWY-5067") +AnnotationAssertion( "MetaCyc:PWY-7900") +AnnotationAssertion(rdfs:label "glycogen biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (regulation of glycogen biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.") +AnnotationAssertion(rdfs:label "regulation of glycogen biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (glycogen catabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.") +AnnotationAssertion( "MetaCyc:GLYCOCAT-PWY") +AnnotationAssertion( "MetaCyc:PWY-5941") +AnnotationAssertion( "MetaCyc:PWY-7662") +AnnotationAssertion(rdfs:label "glycogen catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (regulation of glycogen catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.") +AnnotationAssertion(rdfs:label "regulation of glycogen catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (glucose metabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.") +AnnotationAssertion(rdfs:label "glucose metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (glucose catabolic process) + +AnnotationAssertion(Annotation( "GOC:ai") "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose.") +AnnotationAssertion(rdfs:label "glucose catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (glycosaminoglycan biosynthetic process) +AnnotationAssertion(Annotation( "ISBN:0192800981") "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.") AnnotationAssertion(rdfs:label "glycosaminoglycan biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (glycosaminoglycan catabolic process) + +AnnotationAssertion(Annotation( "ISBN:0192800981") "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars.") +AnnotationAssertion(rdfs:label "glycosaminoglycan catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (organic acid metabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.") +AnnotationAssertion(rdfs:label "organic acid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (generation of precursor metabolites and energy) + +AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.") +AnnotationAssertion(rdfs:label "generation of precursor metabolites and energy") +SubClassOf( ) + +# Class: (gluconeogenesis) + +AnnotationAssertion(Annotation( "MetaCyc:GLUCONEO-PWY") "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.") +AnnotationAssertion( "MetaCyc:GLUCONEO-PWY") +AnnotationAssertion( "Wikipedia:Gluconeogenesis") +AnnotationAssertion(rdfs:label "gluconeogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of carbohydrate metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.") AnnotationAssertion(rdfs:label "regulation of carbohydrate metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (regulation of gluconeogenesis) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.") +AnnotationAssertion(rdfs:label "regulation of gluconeogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (energy reserve metabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.") +AnnotationAssertion(rdfs:label "energy reserve metabolic process") +SubClassOf( ) + # Class: (nucleobase-containing compound metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.") AnnotationAssertion(rdfs:label "nucleobase-containing compound metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (DNA metabolic process) +AnnotationAssertion(Annotation( "ISBN:0198506732") "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.") AnnotationAssertion(rdfs:label "DNA metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (DNA catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0198506732") "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.") +AnnotationAssertion(rdfs:label "DNA catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (apoptotic DNA fragmentation) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") Annotation( "ISBN:0721639976") Annotation( "PMID:15723341") Annotation( "PMID:23379520") "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.") +AnnotationAssertion(rdfs:comment "DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).") +AnnotationAssertion(rdfs:label "apoptotic DNA fragmentation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (chromatin organization) +AnnotationAssertion(Annotation( "PMID:20404130") "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.") AnnotationAssertion(rdfs:label "chromatin organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (RNA catabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.") +AnnotationAssertion(rdfs:label "RNA catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (RNA localization) +AnnotationAssertion(Annotation( "GOC:ai") "A process in which RNA is transported to, or maintained in, a specific location.") AnnotationAssertion(rdfs:label "RNA localization") SubClassOf( ) # Class: (translation) +AnnotationAssertion(Annotation( "GOC:go_curators") "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.") +AnnotationAssertion( "Wikipedia:Translation_(genetics)") AnnotationAssertion(rdfs:label "translation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12140,6 +15813,7 @@ SubClassOf( ObjectSomeValuesFrom( (translational initiation) +AnnotationAssertion(Annotation( "ISBN:019879276X") "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.") AnnotationAssertion(rdfs:label "translational initiation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -12147,52 +15821,68 @@ SubClassOf( ObjectSomeValuesFrom( (translational elongation) +AnnotationAssertion(Annotation( "GOC:ems") "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.") AnnotationAssertion(rdfs:label "translational elongation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (translational termination) +AnnotationAssertion(Annotation( "GOC:hjd") Annotation( "ISBN:019879276X") "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).") AnnotationAssertion(rdfs:label "translational termination") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of translation) +AnnotationAssertion(Annotation( "GOC:isa_complete") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.") AnnotationAssertion(rdfs:label "regulation of translation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of translational initiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of translational initiation.") AnnotationAssertion(rdfs:label "regulation of translational initiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of translational elongation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate, extent or accuracy of translational elongation.") AnnotationAssertion(rdfs:label "regulation of translational elongation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of translational termination) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of translational termination.") AnnotationAssertion(rdfs:label "regulation of translational termination") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (glycoprotein catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.") +AnnotationAssertion(rdfs:label "glycoprotein catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (peptide metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.") AnnotationAssertion(rdfs:label "peptide metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (biogenic amine metabolic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0395825172") "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.") AnnotationAssertion(rdfs:label "biogenic amine metabolic process") SubClassOf( ) # Class: (catecholamine metabolic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.") AnnotationAssertion(rdfs:label "catecholamine metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12200,45 +15890,89 @@ SubClassOf( (lipid metabolic process) +AnnotationAssertion(Annotation( "GOC:ma") "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.") +AnnotationAssertion( "Wikipedia:Lipid_metabolism") AnnotationAssertion(rdfs:label "lipid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (steroid biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.") +AnnotationAssertion( "Wikipedia:Steroid_metabolisms#Steroid_biosynthesis") +AnnotationAssertion(rdfs:label "steroid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (bile acid biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.") +AnnotationAssertion(rdfs:label "bile acid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) + +# Class: (steroid catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.") +AnnotationAssertion(rdfs:label "steroid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (transport) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.") +AnnotationAssertion(rdfs:comment "Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.") AnnotationAssertion(rdfs:label "transport") SubClassOf( ) # Class: (monoatomic ion transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.") AnnotationAssertion(rdfs:label "monoatomic ion transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (serotonin transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.") AnnotationAssertion(rdfs:label "serotonin transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (extracellular transport) +AnnotationAssertion(Annotation( "GOC:go_curators") "The transport of substances that occurs outside cells.") AnnotationAssertion(rdfs:label "extracellular transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (lipid transport) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.") AnnotationAssertion(rdfs:label "lipid transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (intracellular monoatomic ion homeostasis) + +AnnotationAssertion(Annotation( "GOC:mah") "A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.") +AnnotationAssertion(rdfs:label "intracellular monoatomic ion homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (intracellular protein transport) +AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.") AnnotationAssertion(rdfs:label "intracellular protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (exocytosis) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0716731363") Annotation( "PMID:22323285") "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.") +AnnotationAssertion( "Wikipedia:Exocytosis") AnnotationAssertion(rdfs:label "exocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12246,17 +15980,20 @@ SubClassOf( ObjectSomeValuesFrom( (post-Golgi vesicle-mediated transport) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mah") "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.") AnnotationAssertion(rdfs:label "post-Golgi vesicle-mediated transport") SubClassOf( ) # Class: (Golgi to plasma membrane transport) +AnnotationAssertion(Annotation( "ISBN:0716731363") "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.") AnnotationAssertion(rdfs:label "Golgi to plasma membrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (Golgi to vacuole transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of substances from the Golgi to the vacuole.") AnnotationAssertion(rdfs:label "Golgi to vacuole transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12264,6 +16001,8 @@ SubClassOf( (endocytosis) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") Annotation( "ISBN:0716731363") Annotation( "Wikipedia:Endocytosis") "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.") +AnnotationAssertion( "Wikipedia:Endocytosis") AnnotationAssertion(rdfs:label "endocytosis") SubClassOf( ) SubClassOf( ) @@ -12274,6 +16013,7 @@ SubClassOf( ObjectSomeValuesFrom( (vesicle budding from membrane) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:tb") "The evagination of a membrane, resulting in formation of a vesicle.") AnnotationAssertion(rdfs:label "vesicle budding from membrane") SubClassOf( ) SubClassOf( ) @@ -12281,6 +16021,7 @@ SubClassOf( ObjectSomeValuesFrom( (vesicle targeting) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:17335816") "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.") AnnotationAssertion(rdfs:label "vesicle targeting") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -12288,6 +16029,7 @@ SubClassOf( ObjectSomeValuesFrom( (vesicle fusion) +AnnotationAssertion(Annotation( "GOC:jid") "Fusion of the membrane of a transport vesicle with its target membrane.") AnnotationAssertion(rdfs:label "vesicle fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12298,6 +16040,8 @@ SubClassOf( ObjectSomeValuesFrom( (phagocytosis) +AnnotationAssertion(Annotation( "ISBN:0198506732") "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.") +AnnotationAssertion( "Wikipedia:Phagocytosis") AnnotationAssertion(rdfs:label "phagocytosis") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -12306,6 +16050,8 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (apoptotic process) +AnnotationAssertion(Annotation( "GOC:cjm") Annotation( "GOC:dhl") Annotation( "GOC:ecd") Annotation( "GOC:go_curators") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") Annotation( "ISBN:0198506732") Annotation( "PMID:18846107") Annotation( "PMID:21494263") "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.") +AnnotationAssertion( "Wikipedia:Apoptosis") AnnotationAssertion(rdfs:label "apoptotic process") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -12321,58 +16067,70 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (cellular component disassembly involved in execution phase of apoptosis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.") AnnotationAssertion(rdfs:label "cellular component disassembly involved in execution phase of apoptosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (inflammatory cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_apoptosis") "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage.") AnnotationAssertion(rdfs:label "inflammatory cell apoptotic process") SubClassOf( ) # Class: (chemotaxis) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).") +AnnotationAssertion( "Wikipedia:Chemotaxis") AnnotationAssertion(rdfs:label "chemotaxis") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (muscle contraction) +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "GOC:mtg_muscle") Annotation( "ISBN:0198506732") "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.") +AnnotationAssertion( "Wikipedia:Muscle_contraction") AnnotationAssertion(rdfs:label "muscle contraction") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of muscle contraction) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of muscle contraction.") AnnotationAssertion(rdfs:label "regulation of muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (smooth muscle contraction) +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "GOC:jl") Annotation( "GOC:mtg_muscle") Annotation( "ISBN:0198506732") "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.") AnnotationAssertion(rdfs:label "smooth muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of smooth muscle contraction) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of smooth muscle contraction.") AnnotationAssertion(rdfs:label "regulation of smooth muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (striated muscle contraction) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_muscle") Annotation( "ISBN:0198506732") "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.") AnnotationAssertion(rdfs:label "striated muscle contraction") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of striated muscle contraction) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of striated muscle contraction.") AnnotationAssertion(rdfs:label "regulation of striated muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (syncytium formation) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.") AnnotationAssertion(rdfs:label "syncytium formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12381,16 +16139,21 @@ SubClassOf( (response to stress) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "response to stress") SubClassOf( ) # Class: (defense response) +AnnotationAssertion(Annotation( "GOC:go_curators") "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.") AnnotationAssertion(rdfs:label "defense response") SubClassOf( ) # Class: (inflammatory response) +AnnotationAssertion(Annotation( "GO_REF:0000022") Annotation( "ISBN:0198506732") "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.") +AnnotationAssertion( "Wikipedia:Inflammation") AnnotationAssertion(rdfs:label "inflammatory response") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -12398,22 +16161,27 @@ SubClassOf( ObjectAllValuesFrom( (immune response) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.") AnnotationAssertion(rdfs:label "immune response") SubClassOf( ) SubClassOf( ) # Class: (organelle organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "organelle organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (nucleus organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:ems") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.") AnnotationAssertion(rdfs:label "nucleus organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (nuclear envelope organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:ems") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.") AnnotationAssertion(rdfs:label "nuclear envelope organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12422,12 +16190,14 @@ SubClassOf( ObjectSomeValuesFrom( (nucleolus organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus.") AnnotationAssertion(rdfs:label "nucleolus organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (plasma membrane organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.") AnnotationAssertion(rdfs:label "plasma membrane organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12435,27 +16205,32 @@ SubClassOf( ObjectSomeValuesFrom( (cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.") AnnotationAssertion(rdfs:label "cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (actin filament organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.") AnnotationAssertion(rdfs:label "actin filament organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (microtubule-based process) +AnnotationAssertion(Annotation( "GOC:mah") "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.") AnnotationAssertion(rdfs:label "microtubule-based process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (microtubule-based movement) +AnnotationAssertion(Annotation( "GOC:cjm") Annotation( "ISBN:0815316194") "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.") AnnotationAssertion(rdfs:label "microtubule-based movement") SubClassOf( ) # Class: (microtubule depolymerization) +AnnotationAssertion(Annotation( "ISBN:0815316194") "The removal of tubulin heterodimers from one or both ends of a microtubule.") AnnotationAssertion(rdfs:label "microtubule depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12463,45 +16238,61 @@ SubClassOf( (microtubule nucleation) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0815316194") Annotation( "PMID:12517712") "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).") +AnnotationAssertion( "Wikipedia:Microtubule_nucleation") AnnotationAssertion(rdfs:label "microtubule nucleation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of microtubule depolymerization) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.") AnnotationAssertion(rdfs:label "negative regulation of microtubule depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of axonemal microtubule depolymerization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme.") AnnotationAssertion(rdfs:label "negative regulation of axonemal microtubule depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cytoplasm organization) +AnnotationAssertion(Annotation( "GOC:curators") Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.") AnnotationAssertion(rdfs:label "cytoplasm organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (Golgi organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.") AnnotationAssertion(rdfs:label "Golgi organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vacuole organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.") AnnotationAssertion(rdfs:label "vacuole organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (vacuolar transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of substances into, out of or within a vacuole.") AnnotationAssertion(rdfs:label "vacuolar transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (protein catabolic process in the vacuole) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:vw") "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases.") +AnnotationAssertion(rdfs:label "protein catabolic process in the vacuole") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (lysosome organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.") AnnotationAssertion(rdfs:label "lysosome organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -12510,6 +16301,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (lysosomal transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of substances into, out of or within a lysosome.") AnnotationAssertion(rdfs:label "lysosomal transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12519,50 +16311,64 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (cell-cell junction assembly) +AnnotationAssertion(Annotation( "GOC:ai") "The aggregation, arrangement and bonding together of a set of components to form a junction between cells.") AnnotationAssertion(rdfs:label "cell-cell junction assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell cycle) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_cell_cycle") "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.") +AnnotationAssertion( "Wikipedia:Cell_cycle") AnnotationAssertion(rdfs:label "cell cycle") SubClassOf( ) # Class: (chromosome segregation) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mah") Annotation( "GOC:mtg_cell_cycle") Annotation( "GOC:vw") "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.") +AnnotationAssertion( "Wikipedia:Chromosome_segregation") AnnotationAssertion(rdfs:label "chromosome segregation") SubClassOf( ) SubClassOf( ) # Class: (mitotic chromosome condensation) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.") AnnotationAssertion(rdfs:label "mitotic chromosome condensation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (mitotic nuclear membrane disassembly) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "PMID:32848252") "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis.") AnnotationAssertion(rdfs:label "mitotic nuclear membrane disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of mitotic nuclear division) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of mitosis.") AnnotationAssertion(rdfs:label "regulation of mitotic nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (nuclear migration) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of the nucleus to a specific location within a cell.") AnnotationAssertion(rdfs:label "nuclear migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (endomitotic cell cycle) +AnnotationAssertion(Annotation( "GOC:curators") Annotation( "GOC:dos") Annotation( "GOC:expert_vm") "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.") +AnnotationAssertion( "Wikipedia:Mitosis#Endomitosis") +AnnotationAssertion(rdfs:comment "Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins.") AnnotationAssertion(rdfs:label "endomitotic cell cycle") SubClassOf( ) # Class: (female meiotic nuclear division) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:ems") Annotation( "GOC:mah") Annotation( "GOC:vw") "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.") +AnnotationAssertion(rdfs:comment "Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'.") AnnotationAssertion(rdfs:label "female meiotic nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12572,16 +16378,21 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (cell communication) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.") +AnnotationAssertion( "Wikipedia:Cell_signaling") AnnotationAssertion(rdfs:label "cell communication") SubClassOf( ) # Class: (cell adhesion) +AnnotationAssertion(Annotation( "GOC:hb") Annotation( "GOC:pf") "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.") +AnnotationAssertion( "Wikipedia:Cell_adhesion") AnnotationAssertion(rdfs:label "cell adhesion") SubClassOf( ) # Class: (leukocyte cell-cell adhesion) +AnnotationAssertion(Annotation( "GOC:go_curators") "The attachment of a leukocyte to another cell via adhesion molecules.") AnnotationAssertion(rdfs:label "leukocyte cell-cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -12591,6 +16402,7 @@ SubClassOf( ObjectAllValuesFrom( (negative regulation of cell adhesion) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.") AnnotationAssertion(rdfs:label "negative regulation of cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12598,11 +16410,15 @@ SubClassOf( (establishment or maintenance of cell polarity) +AnnotationAssertion(Annotation( "GOC:mah") "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.") AnnotationAssertion(rdfs:label "establishment or maintenance of cell polarity") SubClassOf( ) # Class: (signal transduction) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_signaling_feb11") "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.") +AnnotationAssertion( "Wikipedia:Signal_transduction") +AnnotationAssertion(rdfs:comment "Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.") AnnotationAssertion(rdfs:label "signal transduction") SubClassOf( ) SubClassOf( ) @@ -12612,12 +16428,15 @@ SubClassOf( ObjectSomeValuesFrom( (cell-cell signaling) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:mah") "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.") AnnotationAssertion(rdfs:label "cell-cell signaling") SubClassOf( ) SubClassOf( ) # Class: (chemical synaptic transmission) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "MeSH:D009435") "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.") +AnnotationAssertion( "Wikipedia:Neurotransmission") AnnotationAssertion(rdfs:label "chemical synaptic transmission") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -12626,6 +16445,8 @@ SubClassOf( ObjectSomeValuesFrom( (multicellular organism development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:ems") Annotation( "GOC:isa_complete") Annotation( "GOC:tb") "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).") +AnnotationAssertion(rdfs:comment "Note that this term was 'developmental process'.") AnnotationAssertion(rdfs:label "multicellular organism development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12634,6 +16455,7 @@ SubClassOf( (gamete generation) +AnnotationAssertion(Annotation( "GOC:ems") Annotation( "GOC:mtg_sensu") "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.") AnnotationAssertion(rdfs:label "gamete generation") SubClassOf( ) SubClassOf( ) @@ -12641,6 +16463,7 @@ SubClassOf( ObjectSomeValuesFrom( (germ cell development) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.") AnnotationAssertion(rdfs:label "germ cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12650,11 +16473,13 @@ SubClassOf( ObjectSomeValuesFrom( (female gamete generation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0198506732") "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.") AnnotationAssertion(rdfs:label "female gamete generation") SubClassOf( ) # Class: (germarium-derived egg chamber formation) +AnnotationAssertion(Annotation( "GOC:mtg_sensu") Annotation( "ISBN:0879694238") "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.") AnnotationAssertion(rdfs:label "germarium-derived egg chamber formation") SubClassOf( ) SubClassOf( ) @@ -12665,6 +16490,7 @@ SubClassOf( ObjectAllValuesFrom( (oocyte construction) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:ems") Annotation( "GOC:mtg_sensu") Annotation( "GOC:tb") Annotation( "ISBN:0198506732") "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster.") AnnotationAssertion(rdfs:label "oocyte construction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12673,6 +16499,7 @@ SubClassOf( ObjectSomeValuesFrom( (single fertilization) +AnnotationAssertion(Annotation( "GOC:ems") Annotation( "GOC:mtg_sensu") "The union of male and female gametes to form a zygote.") AnnotationAssertion(rdfs:label "single fertilization") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -12683,6 +16510,8 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (egg activation) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "PMID:9630751") "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm.") +AnnotationAssertion( "Wikipedia:Egg_activation") AnnotationAssertion(rdfs:label "egg activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12690,17 +16519,21 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of mitotic cell cycle) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "Any process that modulates the rate or extent of progress through the mitotic cell cycle.") AnnotationAssertion(rdfs:label "regulation of mitotic cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (blastoderm segmentation) +AnnotationAssertion(Annotation( "ISBN:0879694238") Annotation( "http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm") "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.") AnnotationAssertion(rdfs:label "blastoderm segmentation") SubClassOf( ) SubClassOf( ) # Class: (gastrulation) +AnnotationAssertion(Annotation( "GOC:curators") Annotation( "ISBN:9780878933846") "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.") +AnnotationAssertion( "Wikipedia:Gastrulation") AnnotationAssertion(rdfs:label "gastrulation") SubClassOf( ) SubClassOf( ) @@ -12710,24 +16543,28 @@ SubClassOf( ObjectSomeValuesFrom( (pattern specification process) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:isa_complete") Annotation( "ISBN:0521436125") "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.") AnnotationAssertion(rdfs:label "pattern specification process") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (ectoderm development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.") AnnotationAssertion(rdfs:label "ectoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (nervous system development) +AnnotationAssertion(Annotation( "GOC:dgh") "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.") AnnotationAssertion(rdfs:label "nervous system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (neuroblast proliferation) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mtg_sensu") Annotation( "GOC:sart") "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.") AnnotationAssertion(rdfs:label "neuroblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12737,12 +16574,14 @@ SubClassOf( ObjectAllValuesFrom( (negative regulation of neuroblast proliferation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.") AnnotationAssertion(rdfs:label "negative regulation of neuroblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (neuroblast activation) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.") AnnotationAssertion(rdfs:label "neuroblast activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12752,12 +16591,16 @@ SubClassOf( ObjectAllValuesFrom( (synapse assembly) +AnnotationAssertion(Annotation( "GOC:mah") "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).") +AnnotationAssertion( "Wikipedia:Synaptogenesis") AnnotationAssertion(rdfs:label "synapse assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (central nervous system development) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:jid") Annotation( "ISBN:0582227089") "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.") +AnnotationAssertion( "Wikipedia:Neural_development") AnnotationAssertion(rdfs:label "central nervous system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12765,6 +16608,7 @@ SubClassOf( ObjectSomeValuesFrom( (brain development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:tb") Annotation( "UBERON:0000955") "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).") AnnotationAssertion(rdfs:label "brain development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12774,6 +16618,7 @@ SubClassOf( ObjectSomeValuesFrom( (peripheral nervous system development) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "UBERON:0000010") "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.") AnnotationAssertion(rdfs:label "peripheral nervous system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12781,6 +16626,7 @@ SubClassOf( ObjectSomeValuesFrom( (sensory organ development) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "sensory organ development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12788,6 +16634,7 @@ SubClassOf( (ectodermal digestive tract development) +AnnotationAssertion(Annotation( "GOC:curators") "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm.") AnnotationAssertion(rdfs:label "ectodermal digestive tract development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12795,26 +16642,47 @@ SubClassOf( ObjectSomeValuesFrom( (foregut morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") "The process in which the anatomical structures of the foregut are generated and organized.") AnnotationAssertion(rdfs:label "foregut morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hindgut morphogenesis) + +AnnotationAssertion(Annotation( "GOC:jid") "The process in which the anatomical structures of the hindgut are generated and organized.") +AnnotationAssertion(rdfs:label "hindgut morphogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (endoderm development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.") AnnotationAssertion(rdfs:label "endoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (midgut development) + +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "UBERON:0001045") "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.") +AnnotationAssertion(rdfs:label "midgut development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (mesoderm development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.") AnnotationAssertion(rdfs:label "mesoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (gonadal mesoderm development) +AnnotationAssertion(Annotation( "GOC:ai") "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.") AnnotationAssertion(rdfs:label "gonadal mesoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12823,7 +16691,8 @@ SubClassOf( ObjectSomeValuesFrom( (heart development) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "UBERON:0000948") "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.") +AnnotationAssertion( "Wikipedia:Heart_development") AnnotationAssertion(rdfs:label "heart development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12832,6 +16701,7 @@ SubClassOf( ObjectSomeValuesFrom( (muscle organ development) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "ISBN:0198506732") "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.") AnnotationAssertion(rdfs:label "muscle organ development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12839,22 +16709,28 @@ SubClassOf( (skeletal muscle tissue development) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.") AnnotationAssertion(rdfs:label "skeletal muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (neuromuscular junction development) +AnnotationAssertion(Annotation( "GOC:mtg_OBO2OWL_2013") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.") AnnotationAssertion(rdfs:label "neuromuscular junction development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (sex differentiation) +AnnotationAssertion(Annotation( "GOC:ai") "The establishment of the sex of an organism by physical differentiation.") +AnnotationAssertion( "Wikipedia:Sexual_differentiation") AnnotationAssertion(rdfs:label "sex differentiation") SubClassOf( ) # Class: (female pregnancy) +AnnotationAssertion(Annotation( "ISBN:0192800825") "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.") +AnnotationAssertion( "Wikipedia:Gestation") AnnotationAssertion(rdfs:label "female pregnancy") SubClassOf( ) SubClassOf( ) @@ -12863,6 +16739,7 @@ SubClassOf( ObjectAllValuesFrom( (embryo implantation) +AnnotationAssertion(Annotation( "GOC:isa_complete") Annotation( "PMID:10882512") "Attachment of the blastocyst to the uterine lining.") AnnotationAssertion(rdfs:label "embryo implantation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -12870,59 +16747,108 @@ SubClassOf( ObjectSomeValuesFrom( (respiratory gaseous exchange by respiratory system) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.") AnnotationAssertion(rdfs:label "respiratory gaseous exchange by respiratory system") SubClassOf( ) # Class: (digestion) +AnnotationAssertion(Annotation( "GOC:isa_complete") Annotation( "ISBN:0198506732") "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.") +AnnotationAssertion( "Wikipedia:Digestion") AnnotationAssertion(rdfs:label "digestion") SubClassOf( ) +# Class: (excretion) + +AnnotationAssertion(Annotation( "ISBN:0192801023") "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.") +AnnotationAssertion( "Wikipedia:Excretion") +AnnotationAssertion(rdfs:label "excretion") +SubClassOf( ) + +# Class: (body fluid secretion) + +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:tb") "The controlled release of a fluid by a cell or tissue in an animal.") +AnnotationAssertion(rdfs:label "body fluid secretion") +SubClassOf( ) +SubClassOf( ) + # Class: (sensory perception) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.") +AnnotationAssertion( "Wikipedia:Perception") AnnotationAssertion(rdfs:label "sensory perception") SubClassOf( ) # Class: (visual perception) +AnnotationAssertion(Annotation( "GOC:ai") "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.") +AnnotationAssertion( "Wikipedia:Visual_perception") AnnotationAssertion(rdfs:label "visual perception") SubClassOf( ) # Class: (sensory perception of sound) +AnnotationAssertion(Annotation( "GOC:ai") "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.") +AnnotationAssertion( "Wikipedia:Hearing_(sense)") AnnotationAssertion(rdfs:label "sensory perception of sound") SubClassOf( ) # Class: (sensory perception of chemical stimulus) +AnnotationAssertion(Annotation( "GOC:ai") "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.") AnnotationAssertion(rdfs:label "sensory perception of chemical stimulus") SubClassOf( ) +# Class: (behavior) + +AnnotationAssertion(Annotation( "GOC:ems") Annotation( "GOC:jl") Annotation( "ISBN:0395448956") Annotation( "PMID:20160973") "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.") +AnnotationAssertion( "Wikipedia:Behavior") +AnnotationAssertion(rdfs:comment "1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. +2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).") +AnnotationAssertion(rdfs:label "behavior") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) +DisjointClasses( ) + +# Class: (locomotory behavior) + +AnnotationAssertion(Annotation( "GOC:dph") "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.") +AnnotationAssertion(rdfs:label "locomotory behavior") +SubClassOf( ) + # Class: (blood circulation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") Annotation( "ISBN:0192800825") "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.") AnnotationAssertion(rdfs:label "blood circulation") SubClassOf( ) # Class: (regulation of heart contraction) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.") AnnotationAssertion(rdfs:label "regulation of heart contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (mesodermal cell migration) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:sat") Annotation( "GOC:tb") Annotation( "PMID:25119047") "The orderly movement of mesodermal cells from one site to another.") AnnotationAssertion(rdfs:label "mesodermal cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (axo-dendritic transport) +AnnotationAssertion(Annotation( "ISBN:0815316194") "The directed movement of organelles or molecules along microtubules in neuron projections.") +AnnotationAssertion( "Wikipedia:Axoplasmic_transport") AnnotationAssertion(rdfs:label "axo-dendritic transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein localization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process in which a protein is transported to, or maintained in, a specific location.") AnnotationAssertion(rdfs:label "protein localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12930,22 +16856,49 @@ SubClassOf( (biological_process) +AnnotationAssertion(Annotation( "GOC:pdt") "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.") +AnnotationAssertion( "Wikipedia:Biological_process") +AnnotationAssertion(rdfs:comment "Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.") AnnotationAssertion(rdfs:label "biological_process") SubClassOf( ) # Class: (metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0198547684") "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.") +AnnotationAssertion( "Wikipedia:Metabolism") +AnnotationAssertion(rdfs:comment "Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.") AnnotationAssertion(rdfs:label "metabolic process") SubClassOf( ) DisjointClasses( ) +# Class: (steroid metabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198547684") "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.") +AnnotationAssertion( "Wikipedia:Steroid_metabolism") +AnnotationAssertion(rdfs:label "steroid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (bile acid metabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.") +AnnotationAssertion(rdfs:label "bile acid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (cell death) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:25236395") "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).") +AnnotationAssertion(rdfs:comment "This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms.") AnnotationAssertion(rdfs:label "cell death") SubClassOf( ) # Class: (cell population proliferation) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:mb") "The multiplication or reproduction of cells, resulting in the expansion of a cell population.") +AnnotationAssertion(rdfs:comment "This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.") AnnotationAssertion(rdfs:label "cell population proliferation") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -12954,6 +16907,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (positive regulation of cell population proliferation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the rate or extent of cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of cell population proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12964,6 +16918,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (negative regulation of cell population proliferation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents or reduces the rate or extent of cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of cell population proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12972,8 +16927,36 @@ SubClassOf( ObjectComplementOf(Object SubClassOf( ObjectSomeValuesFrom( ObjectComplementOf())) DisjointClasses( ObjectSomeValuesFrom( )) +# Class: (protein transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:jl") "Enables the transfer of a protein from one side of a membrane to the other.") +AnnotationAssertion(Annotation(rdfs:label "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space") "Reactome:R-HSA-1268022") +AnnotationAssertion(Annotation(rdfs:label "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix") "Reactome:R-HSA-1299475") +AnnotationAssertion(Annotation(rdfs:label "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex") "Reactome:R-HSA-184269") +AnnotationAssertion(Annotation(rdfs:label "Transport of GAG to the Plasma Membrane") "Reactome:R-HSA-3149434") +AnnotationAssertion(Annotation(rdfs:label "Pink1 is recruited from the cytoplasm to the mitochondria") "Reactome:R-HSA-5205661") +AnnotationAssertion(Annotation(rdfs:label "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)") "Reactome:R-HSA-5210943") +AnnotationAssertion(Annotation(rdfs:label "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)") "Reactome:R-HSA-5210947") +AnnotationAssertion(Annotation(rdfs:label "tetX HC transports tetX LC from target cell endosome membrane into cytosol") "Reactome:R-HSA-5228406") +AnnotationAssertion(Annotation(rdfs:label "AP4 transports APP from trans-Golgi network to endosome lumen") "Reactome:R-HSA-5229111") +AnnotationAssertion(Annotation(rdfs:label "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol") "Reactome:R-HSA-5244404") +AnnotationAssertion(Annotation(rdfs:label "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol") "Reactome:R-HSA-5244428") +AnnotationAssertion(Annotation(rdfs:label "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol") "Reactome:R-HSA-5244506") +AnnotationAssertion(Annotation(rdfs:label "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol") "Reactome:R-HSA-5246514") +AnnotationAssertion(Annotation(rdfs:label "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol") "Reactome:R-HSA-5250616") +AnnotationAssertion(Annotation(rdfs:label "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol") "Reactome:R-HSA-5250884") +AnnotationAssertion(Annotation(rdfs:label "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol") "Reactome:R-HSA-5250972") +AnnotationAssertion(Annotation(rdfs:label "DT fragment B transports DT fragment A from target cell endosome membrane") "Reactome:R-HSA-5336420") +AnnotationAssertion(Annotation(rdfs:label "SecA2 transports SapM from cytoplasm to cytosol") "Reactome:R-HSA-9636375") +AnnotationAssertion(Annotation(rdfs:label "HCMV C Nucleocapsid Translocation") "Reactome:R-HSA-9698930") +AnnotationAssertion(Annotation(rdfs:label "HCMV B Nucleocapsid Translocation") "Reactome:R-HSA-9698933") +AnnotationAssertion(rdfs:label "protein transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (glial cell migration) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_sensu") "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.") AnnotationAssertion(rdfs:label "glial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12983,6 +16966,7 @@ SubClassOf( ObjectAllValuesFrom( (germ cell migration) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:jl") "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.") AnnotationAssertion(rdfs:label "germ cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -12990,11 +16974,14 @@ SubClassOf( ObjectSomeValuesFrom( (asymmetric cell division) +AnnotationAssertion(Annotation( "PMID:11672519") "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.") +AnnotationAssertion( "Wikipedia:Asymmetric_cell_division") AnnotationAssertion(rdfs:label "asymmetric cell division") SubClassOf( ) # Class: (gonad development) +AnnotationAssertion(Annotation( "GOC:ems") Annotation( "ISBN:0198506732") "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.") AnnotationAssertion(rdfs:label "gonad development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13005,6 +16992,7 @@ SubClassOf( ObjectSomeValuesFrom( (epidermis development) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "UBERON:0001003") "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.") AnnotationAssertion(rdfs:label "epidermis development") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -13013,6 +17001,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (female gonad development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:tb") "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "female gonad development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13023,6 +17012,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (photoreceptor cell morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mah") "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.") AnnotationAssertion(rdfs:label "photoreceptor cell morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13030,23 +17020,49 @@ SubClassOf( ObjectSomeValuesFrom( (lipid biosynthetic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.") AnnotationAssertion(rdfs:label "lipid biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (carbohydrate transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.") AnnotationAssertion(rdfs:label "carbohydrate transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (hexose transmembrane transport) + +AnnotationAssertion(Annotation( "GOC:vw") "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule.") +AnnotationAssertion(rdfs:comment "Note that this term is not intended for use in annotating lateral movement within membranes.") +AnnotationAssertion(rdfs:label "hexose transmembrane transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) + +# Class: (catabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198547684") "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.") +AnnotationAssertion( "Wikipedia:Catabolism") +AnnotationAssertion(rdfs:label "catabolic process") +SubClassOf( ) + +# Class: (macromolecule catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.") +AnnotationAssertion(rdfs:label "macromolecule catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (biosynthetic process) +AnnotationAssertion(Annotation( "GOC:curators") Annotation( "ISBN:0198547684") "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.") +AnnotationAssertion( "Wikipedia:Anabolism") AnnotationAssertion(rdfs:label "biosynthetic process") SubClassOf( ) # Class: (macromolecule biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "macromolecule biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13054,17 +17070,34 @@ SubClassOf( (glycoprotein metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.") AnnotationAssertion(rdfs:label "glycoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (glycoprotein biosynthetic process) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.") AnnotationAssertion(rdfs:label "glycoprotein biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (glucan biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.") +AnnotationAssertion(rdfs:label "glucan biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (glucan catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues.") +AnnotationAssertion(rdfs:label "glucan catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (protein secretion) +AnnotationAssertion(Annotation( "GOC:ai") "The controlled release of proteins from a cell.") AnnotationAssertion(rdfs:label "protein secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13072,46 +17105,62 @@ SubClassOf( (amine metabolic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.") AnnotationAssertion(rdfs:label "amine metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (amine biosynthetic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.") AnnotationAssertion(rdfs:label "amine biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (amine catabolic process) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.") +AnnotationAssertion(rdfs:label "amine catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (response to radiation) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "Wikipedia:Electromagnetic_radiation") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.") +AnnotationAssertion(rdfs:comment "Note that 'radiation' refers to electromagnetic radiation of any wavelength.") AnnotationAssertion(rdfs:label "response to radiation") SubClassOf( ) # Class: (response to light stimulus) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0582227089") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.") AnnotationAssertion(rdfs:label "response to light stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (fertilization) +AnnotationAssertion(Annotation( "GOC:tb") Annotation( "ISBN:0198506732") "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).") +AnnotationAssertion( "Wikipedia:Fertilisation") AnnotationAssertion(rdfs:label "fertilization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (detection of external stimulus) +AnnotationAssertion(Annotation( "GOC:hb") "The series of events in which an external stimulus is received by a cell and converted into a molecular signal.") AnnotationAssertion(rdfs:label "detection of external stimulus") SubClassOf( ) SubClassOf( ) # Class: (detection of abiotic stimulus) +AnnotationAssertion(Annotation( "GOC:hb") "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.") AnnotationAssertion(rdfs:label "detection of abiotic stimulus") SubClassOf( ) SubClassOf( ) # Class: (detection of light stimulus) +AnnotationAssertion(Annotation( "GOC:go_curators") "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.") AnnotationAssertion(rdfs:label "detection of light stimulus") SubClassOf( ) SubClassOf( ) @@ -13119,44 +17168,62 @@ SubClassOf( (detection of visible light) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0198506732") "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.") AnnotationAssertion(rdfs:label "detection of visible light") SubClassOf( ) # Class: (detection of chemical stimulus) +AnnotationAssertion(Annotation( "GOC:jl") "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.") AnnotationAssertion(rdfs:label "detection of chemical stimulus") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (response to external stimulus) +AnnotationAssertion(Annotation( "GOC:hb") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "response to external stimulus") SubClassOf( ) # Class: (response to biotic stimulus) +AnnotationAssertion(Annotation( "GOC:hb") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "response to biotic stimulus") SubClassOf( ) # Class: (response to bacterium) +AnnotationAssertion(Annotation( "GOC:hb") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.") AnnotationAssertion(rdfs:label "response to bacterium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (response to fungus) +AnnotationAssertion(Annotation( "GOC:hb") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.") AnnotationAssertion(rdfs:label "response to fungus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (response to abiotic stimulus) +AnnotationAssertion(Annotation( "GOC:hb") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "response to abiotic stimulus") SubClassOf( ) +# Class: (response to toxic substance) + +AnnotationAssertion(Annotation( "GOC:lr") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.") +AnnotationAssertion(rdfs:label "response to toxic substance") +SubClassOf( ) + # Class: (anatomical structure morphogenesis) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0521436125") "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.") +AnnotationAssertion( "Wikipedia:Morphogenesis") AnnotationAssertion(rdfs:label "anatomical structure morphogenesis") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -13165,22 +17232,27 @@ DisjointClasses( (catechol-containing compound metabolic process) +AnnotationAssertion(Annotation( "GOC:sm") Annotation( "ISBN:0198547684") "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent.") AnnotationAssertion(rdfs:label "catechol-containing compound metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (catechol-containing compound biosynthetic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.") AnnotationAssertion(rdfs:label "catechol-containing compound biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (response to endogenous stimulus) +AnnotationAssertion(Annotation( "GOC:sm") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "response to endogenous stimulus") SubClassOf( ) # Class: (response to hormone) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.") AnnotationAssertion(rdfs:label "response to hormone") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -13192,16 +17264,32 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (response to carbohydrate) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.") AnnotationAssertion(rdfs:label "response to carbohydrate") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (response to hexose) + +AnnotationAssertion(Annotation( "GOC:jl") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.") +AnnotationAssertion(rdfs:label "response to hexose") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (response to glucose) + +AnnotationAssertion(Annotation( "GOC:jl") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.") +AnnotationAssertion(rdfs:label "response to glucose") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of asymmetric cell division) +AnnotationAssertion(Annotation( "GOC:lr") "Any process that modulates the frequency, rate or extent of asymmetric cell division.") AnnotationAssertion(rdfs:label "regulation of asymmetric cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (embryo development) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:isa_complete") Annotation( "GOC:mtg_sensu") "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.") +AnnotationAssertion( "Wikipedia:Embryogenesis") AnnotationAssertion(rdfs:label "embryo development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13210,12 +17298,14 @@ SubClassOf( (post-embryonic development) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.") AnnotationAssertion(rdfs:label "post-embryonic development") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (embryo development ending in birth or egg hatching) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:isa_complete") Annotation( "GOC:mtg_sensu") "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.") AnnotationAssertion(rdfs:label "embryo development ending in birth or egg hatching") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -13223,12 +17313,14 @@ SubClassOf( ObjectAllValuesFrom( (embryonic pattern specification) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0521436125") "The process that results in the patterns of cell differentiation that will arise in an embryo.") AnnotationAssertion(rdfs:label "embryonic pattern specification") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (animal organ morphogenesis) +AnnotationAssertion(Annotation( "GOC:dgh") Annotation( "GOC:go_curators") Annotation( "ISBN:0471245208") Annotation( "ISBN:0721662544") "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.") AnnotationAssertion(rdfs:label "animal organ morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13239,6 +17331,8 @@ SubClassOf( ObjectAllValuesFrom( (tissue development) +AnnotationAssertion(Annotation( "ISBN:0471245208") "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.") +AnnotationAssertion( "Wikipedia:Histogenesis") AnnotationAssertion(rdfs:label "tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13262,12 +17356,14 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (regulation of biosynthetic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.") AnnotationAssertion(rdfs:label "regulation of biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of biosynthetic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.") AnnotationAssertion(rdfs:label "negative regulation of biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13275,6 +17371,7 @@ SubClassOf( (positive regulation of biosynthetic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.") AnnotationAssertion(rdfs:label "positive regulation of biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13282,16 +17379,42 @@ SubClassOf( (negative regulation of metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.") AnnotationAssertion(rdfs:label "negative regulation of metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.") AnnotationAssertion(rdfs:label "positive regulation of metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.") +AnnotationAssertion(rdfs:label "regulation of catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (negative regulation of catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.") +AnnotationAssertion(rdfs:label "negative regulation of catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.") +AnnotationAssertion(rdfs:label "positive regulation of catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (epidermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.") AnnotationAssertion(rdfs:label "epidermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13299,17 +17422,20 @@ SubClassOf( ObjectSomeValuesFrom( (hormone transport) +AnnotationAssertion(Annotation( "GOC:tb") "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "hormone transport") SubClassOf( ) SubClassOf( ) # Class: (anterior/posterior pattern specification) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:isa_complete") Annotation( "GOC:tb") "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.") AnnotationAssertion(rdfs:label "anterior/posterior pattern specification") SubClassOf( ) # Class: (regulation of signal transduction) +AnnotationAssertion(Annotation( "GOC:sm") "Any process that modulates the frequency, rate or extent of signal transduction.") AnnotationAssertion(rdfs:label "regulation of signal transduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13318,6 +17444,7 @@ SubClassOf( (positive regulation of signal transduction) +AnnotationAssertion(Annotation( "GOC:sm") "Any process that activates or increases the frequency, rate or extent of signal transduction.") AnnotationAssertion(rdfs:label "positive regulation of signal transduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13327,6 +17454,7 @@ SubClassOf( (negative regulation of signal transduction) +AnnotationAssertion(Annotation( "GOC:sm") "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.") AnnotationAssertion(rdfs:label "negative regulation of signal transduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13336,11 +17464,14 @@ SubClassOf( (cellular process) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:isa_complete") "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.") +AnnotationAssertion(rdfs:comment "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.") AnnotationAssertion(rdfs:label "cellular process") SubClassOf( ) # Class: (oocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.") AnnotationAssertion(rdfs:label "oocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13349,6 +17480,7 @@ SubClassOf( ObjectSomeValuesFrom( (glial cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.") AnnotationAssertion(rdfs:label "glial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13358,23 +17490,27 @@ SubClassOf( ObjectAllValuesFrom( (cardioblast differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.") AnnotationAssertion(rdfs:label "cardioblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (meiotic chromosome condensation) +AnnotationAssertion(Annotation( "PMID:10072401") "Compaction of chromatin structure prior to meiosis in eukaryotic cells.") AnnotationAssertion(rdfs:label "meiotic chromosome condensation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (zygote asymmetric cell division) +AnnotationAssertion(Annotation( "GOC:tb") "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials.") AnnotationAssertion(rdfs:label "zygote asymmetric cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (formation of animal organ boundary) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") Annotation( "PMID:9611175") "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues.") AnnotationAssertion(rdfs:label "formation of animal organ boundary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13383,6 +17519,7 @@ SubClassOf( ObjectSomeValuesFrom( (body morphogenesis) +AnnotationAssertion(Annotation( "GOC:ems") Annotation( "ISBN:0140512888") "The process in which the anatomical structures of the soma are generated and organized.") AnnotationAssertion(rdfs:label "body morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13390,62 +17527,77 @@ SubClassOf( (response to organonitrogen compound) +AnnotationAssertion(Annotation( "PMID:9869419") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "response to organonitrogen compound") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (endomembrane system organization) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:sm") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.") AnnotationAssertion(rdfs:label "endomembrane system organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (membrane invagination) +AnnotationAssertion(Annotation( "GOC:tb") "The infolding of a membrane.") AnnotationAssertion(rdfs:label "membrane invagination") SubClassOf( ) # Class: (regulation of cell fate commitment) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.") AnnotationAssertion(rdfs:label "regulation of cell fate commitment") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cell fate commitment) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.") AnnotationAssertion(rdfs:label "negative regulation of cell fate commitment") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of cell fate commitment) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.") AnnotationAssertion(rdfs:label "positive regulation of cell fate commitment") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (mesenchymal cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.") AnnotationAssertion(rdfs:label "mesenchymal cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of mesenchymal cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.") AnnotationAssertion(rdfs:label "regulation of mesenchymal cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (gene expression) +AnnotationAssertion(Annotation( "GOC:txnOH-2018") Annotation( "PMID:25934543") Annotation( "PMID:31580950") "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes.") +AnnotationAssertion( "Wikipedia:Gene_expression") AnnotationAssertion(rdfs:label "gene expression") SubClassOf( ) # Class: (regulation of gene expression) +AnnotationAssertion(Annotation( "GOC:txnOH-2018") "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).") +AnnotationAssertion( "Wikipedia:Regulation_of_gene_expression") +AnnotationAssertion(rdfs:comment "This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.") AnnotationAssertion(rdfs:label "regulation of gene expression") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of gastrulation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.") AnnotationAssertion(rdfs:label "regulation of gastrulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13453,16 +17605,19 @@ SubClassOf( (epidermal cell division) +AnnotationAssertion(Annotation( "PMID:17450124") "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells.") AnnotationAssertion(rdfs:label "epidermal cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of epidermal cell division) +AnnotationAssertion(Annotation( "PMID:17450124") "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis.") AnnotationAssertion(rdfs:label "regulation of epidermal cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (intercellular transport) +AnnotationAssertion(Annotation( "GOC:dhl") "The movement of substances between cells.") AnnotationAssertion(rdfs:label "intercellular transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13470,11 +17625,13 @@ SubClassOf( (regulation of membrane disassembly) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of membrane disassembly.") AnnotationAssertion(rdfs:label "regulation of membrane disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of macromolecule biosynthetic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.") AnnotationAssertion(rdfs:label "regulation of macromolecule biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13482,6 +17639,7 @@ SubClassOf( (positive regulation of macromolecule biosynthetic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.") AnnotationAssertion(rdfs:label "positive regulation of macromolecule biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13490,6 +17648,7 @@ SubClassOf( (negative regulation of macromolecule biosynthetic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.") AnnotationAssertion(rdfs:label "negative regulation of macromolecule biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13498,42 +17657,71 @@ SubClassOf( (regulation of glycoprotein biosynthetic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.") AnnotationAssertion(rdfs:label "regulation of glycoprotein biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of glycoprotein biosynthetic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.") AnnotationAssertion(rdfs:label "positive regulation of glycoprotein biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of glycoprotein biosynthetic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.") AnnotationAssertion(rdfs:label "negative regulation of glycoprotein biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cell cycle process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.") AnnotationAssertion(rdfs:label "regulation of cell cycle process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (regulation of cellular ketone metabolic process) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.") +AnnotationAssertion(rdfs:label "regulation of cellular ketone metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (regulation of ketone biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells.") +AnnotationAssertion(rdfs:label "regulation of ketone biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (regulation of ketone catabolic process) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells.") +AnnotationAssertion(rdfs:label "regulation of ketone catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of endothelial cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.") AnnotationAssertion(rdfs:label "regulation of endothelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of endothelial cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.") AnnotationAssertion(rdfs:label "positive regulation of endothelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of endothelial cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.") AnnotationAssertion(rdfs:label "negative regulation of endothelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of macromolecule metabolic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.") AnnotationAssertion(rdfs:label "positive regulation of macromolecule metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13541,6 +17729,7 @@ SubClassOf( (negative regulation of macromolecule metabolic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.") AnnotationAssertion(rdfs:label "negative regulation of macromolecule metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13548,42 +17737,51 @@ SubClassOf( (post-transcriptional regulation of gene expression) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.") AnnotationAssertion(rdfs:label "post-transcriptional regulation of gene expression") SubClassOf( ) # Class: (regulation of cardiac muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of cardiac muscle adaptation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardiac muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.") AnnotationAssertion(rdfs:label "positive regulation of cardiac muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.") AnnotationAssertion(rdfs:label "negative regulation of cardiac muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardiac muscle adaptation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.") AnnotationAssertion(rdfs:label "positive regulation of cardiac muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac muscle adaptation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.") AnnotationAssertion(rdfs:label "negative regulation of cardiac muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (programmed cell death involved in cell development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "The activation of endogenous cellular processes that result in the death of a cell as part of its development.") +AnnotationAssertion(rdfs:comment "This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure.") AnnotationAssertion(rdfs:label "programmed cell death involved in cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13591,16 +17789,20 @@ SubClassOf( (positive regulation of gene expression) +AnnotationAssertion(Annotation( "GOC:txnOH-2018") "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).") AnnotationAssertion(rdfs:label "positive regulation of gene expression") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of gene expression) +AnnotationAssertion(Annotation( "GOC:txnOH-2018") "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).") +AnnotationAssertion(rdfs:comment "This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.") AnnotationAssertion(rdfs:label "negative regulation of gene expression") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (epithelial cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.") AnnotationAssertion(rdfs:label "epithelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13608,23 +17810,27 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of epithelial cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of epithelial cell migration.") AnnotationAssertion(rdfs:label "regulation of epithelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of epithelial cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.") AnnotationAssertion(rdfs:label "negative regulation of epithelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of epithelial cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of epithelial cell migration.") AnnotationAssertion(rdfs:label "positive regulation of epithelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of organelle organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.") AnnotationAssertion(rdfs:label "positive regulation of organelle organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13632,6 +17838,7 @@ SubClassOf( (negative regulation of organelle organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.") AnnotationAssertion(rdfs:label "negative regulation of organelle organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13639,12 +17846,14 @@ SubClassOf( (regulation of cell communication) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.") AnnotationAssertion(rdfs:label "regulation of cell communication") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of cell communication) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.") AnnotationAssertion(rdfs:label "positive regulation of cell communication") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13652,6 +17861,7 @@ SubClassOf( (negative regulation of cell communication) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.") AnnotationAssertion(rdfs:label "negative regulation of cell communication") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13659,11 +17869,13 @@ SubClassOf( (negative regulation of muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.") AnnotationAssertion(rdfs:label "negative regulation of muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (muscle cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000187") Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle.") AnnotationAssertion(rdfs:label "muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -13671,58 +17883,69 @@ SubClassOf( ObjectAllValuesFrom( (striated muscle cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000737") Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations.") AnnotationAssertion(rdfs:label "striated muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cardiac muscle cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000746") Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.") AnnotationAssertion(rdfs:label "cardiac muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.") AnnotationAssertion(rdfs:label "regulation of muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.") AnnotationAssertion(rdfs:label "positive regulation of muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of striated muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.") AnnotationAssertion(rdfs:label "regulation of striated muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of striated muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.") AnnotationAssertion(rdfs:label "positive regulation of striated muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of striated muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:rl") Annotation( "GOC:tb") "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.") AnnotationAssertion(rdfs:label "negative regulation of striated muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cardiac muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardiac muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.") AnnotationAssertion(rdfs:label "positive regulation of cardiac muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:rl") Annotation( "GOC:tb") "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.") AnnotationAssertion(rdfs:label "negative regulation of cardiac muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (ectodermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.") AnnotationAssertion(rdfs:label "ectodermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13730,6 +17953,7 @@ SubClassOf( ObjectSomeValuesFrom( (negative regulation of norepinephrine secretion) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine.") AnnotationAssertion(rdfs:label "negative regulation of norepinephrine secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13737,55 +17961,77 @@ SubClassOf( (positive regulation of norepinephrine secretion) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine.") AnnotationAssertion(rdfs:label "positive regulation of norepinephrine secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (regulation of collagen catabolic process) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.") +AnnotationAssertion(rdfs:label "regulation of collagen catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of collagen catabolic process) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.") +AnnotationAssertion(rdfs:label "negative regulation of collagen catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of collagen metabolic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.") AnnotationAssertion(rdfs:label "regulation of collagen metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of collagen metabolic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.") AnnotationAssertion(rdfs:label "negative regulation of collagen metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of collagen metabolic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.") AnnotationAssertion(rdfs:label "positive regulation of collagen metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of extracellular matrix disassembly) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.") AnnotationAssertion(rdfs:label "regulation of extracellular matrix disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of extracellular matrix disassembly) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.") AnnotationAssertion(rdfs:label "negative regulation of extracellular matrix disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of epithelial to mesenchymal transition) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.") AnnotationAssertion(rdfs:label "regulation of epithelial to mesenchymal transition") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of epithelial to mesenchymal transition) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.") AnnotationAssertion(rdfs:label "positive regulation of epithelial to mesenchymal transition") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of epithelial to mesenchymal transition) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.") AnnotationAssertion(rdfs:label "negative regulation of epithelial to mesenchymal transition") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of cell development) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.") AnnotationAssertion(rdfs:label "positive regulation of cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13793,6 +18039,7 @@ SubClassOf( (negative regulation of cell development) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.") AnnotationAssertion(rdfs:label "negative regulation of cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13800,11 +18047,13 @@ SubClassOf( (regulation of macrophage chemotaxis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.") AnnotationAssertion(rdfs:label "regulation of macrophage chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of macrophage chemotaxis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.") AnnotationAssertion(rdfs:label "positive regulation of macrophage chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13812,48 +18061,57 @@ SubClassOf( (negative regulation of macrophage chemotaxis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.") AnnotationAssertion(rdfs:label "negative regulation of macrophage chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (fibroblast migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.") AnnotationAssertion(rdfs:label "fibroblast migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of fibroblast migration) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.") AnnotationAssertion(rdfs:label "regulation of fibroblast migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of fibroblast migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.") AnnotationAssertion(rdfs:label "positive regulation of fibroblast migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of fibroblast migration) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.") AnnotationAssertion(rdfs:label "negative regulation of fibroblast migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cell morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.") AnnotationAssertion(rdfs:label "positive regulation of cell morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of cell morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.") AnnotationAssertion(rdfs:label "negative regulation of cell morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of hormone levels) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.") AnnotationAssertion(rdfs:label "regulation of hormone levels") # Class: (T cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.") AnnotationAssertion(rdfs:label "T cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13861,31 +18119,55 @@ SubClassOf( (regulation of T cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.") AnnotationAssertion(rdfs:label "regulation of T cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of T cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.") AnnotationAssertion(rdfs:label "positive regulation of T cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of glucose transmembrane transport) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") +AnnotationAssertion(rdfs:label "regulation of glucose transmembrane transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of glucose transmembrane transport) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") +AnnotationAssertion(rdfs:label "positive regulation of glucose transmembrane transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of glucose transmembrane transport) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") +AnnotationAssertion(rdfs:label "negative regulation of glucose transmembrane transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of myotube differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.") AnnotationAssertion(rdfs:label "regulation of myotube differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myotube differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.") AnnotationAssertion(rdfs:label "positive regulation of myotube differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myotube differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.") AnnotationAssertion(rdfs:label "negative regulation of myotube differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (retina layer formation) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") Annotation( "PMID:1270266") "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.") AnnotationAssertion(rdfs:label "retina layer formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13895,12 +18177,47 @@ SubClassOf( ObjectSomeValuesFrom( (lipid localization) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process in which a lipid is transported to, or maintained in, a specific location.") AnnotationAssertion(rdfs:label "lipid localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (positive regulation of steroid biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.") +AnnotationAssertion(rdfs:label "positive regulation of steroid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (negative regulation of steroid biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.") +AnnotationAssertion(rdfs:label "negative regulation of steroid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (regulation of glucose metabolic process) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.") +AnnotationAssertion(rdfs:label "regulation of glucose metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (positive regulation of glucose metabolic process) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.") +AnnotationAssertion(rdfs:label "positive regulation of glucose metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (cellular component assembly involved in morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The cellular component assembly that is part of the initial shaping of the component during its developmental progression.") AnnotationAssertion(rdfs:label "cellular component assembly involved in morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13909,45 +18226,63 @@ SubClassOf( ObjectSomeValuesFrom( (macrophage cytokine production) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:rl") Annotation( "GOC:tb") "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.") AnnotationAssertion(rdfs:label "macrophage cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of macrophage cytokine production) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:rl") "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") AnnotationAssertion(rdfs:label "regulation of macrophage cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of macrophage cytokine production) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:rl") "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") AnnotationAssertion(rdfs:label "negative regulation of macrophage cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cytoplasmic microtubule depolymerization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization.") AnnotationAssertion(rdfs:label "regulation of cytoplasmic microtubule depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cytoplasmic microtubule depolymerization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule.") AnnotationAssertion(rdfs:label "cytoplasmic microtubule depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of cell cycle process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.") AnnotationAssertion(rdfs:label "negative regulation of cell cycle process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (regulation of glucan biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.") +AnnotationAssertion(rdfs:label "regulation of glucan biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (regulation of microtubule nucleation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.") AnnotationAssertion(rdfs:label "regulation of microtubule nucleation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (transport along microtubule) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:tb") "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.") AnnotationAssertion(rdfs:label "transport along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13955,27 +18290,35 @@ SubClassOf( (regulation of neuron projection development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).") AnnotationAssertion(rdfs:label "regulation of neuron projection development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of neuron projection development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).") AnnotationAssertion(rdfs:label "positive regulation of neuron projection development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of neuron projection development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).") AnnotationAssertion(rdfs:label "negative regulation of neuron projection development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (programmed cell death) +AnnotationAssertion(Annotation( "GOC:lr") Annotation( "GOC:mtg_apoptosis") "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.") +AnnotationAssertion( "Wikipedia:Programmed_cell_death") +AnnotationAssertion(rdfs:comment "Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.") AnnotationAssertion(rdfs:label "programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (endomembrane system) +AnnotationAssertion(Annotation( "GOC:lh") "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.") +AnnotationAssertion( "Wikipedia:Endomembrane_system") AnnotationAssertion(rdfs:label "endomembrane system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -13984,11 +18327,14 @@ SubClassOf( ObjectSomeValuesFrom( (vesicle membrane) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:vesicle") "The lipid bilayer surrounding any membrane-bounded vesicle in the cell.") +AnnotationAssertion( "NIF_Subcellular:sao1153182838") AnnotationAssertion(rdfs:label "vesicle membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (glial cell proliferation) +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "ISBN:0878932585") "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.") AnnotationAssertion(rdfs:label "glial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -13996,39 +18342,46 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of gliogenesis) +AnnotationAssertion(Annotation( "GOC:ef") "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.") AnnotationAssertion(rdfs:label "regulation of gliogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of gliogenesis) +AnnotationAssertion(Annotation( "GOC:ef") "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia.") AnnotationAssertion(rdfs:label "negative regulation of gliogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of gliogenesis) +AnnotationAssertion(Annotation( "GOC:ef") "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia.") AnnotationAssertion(rdfs:label "positive regulation of gliogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (neuroblast differentiation) +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "ISBN:0878932585") "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts.") AnnotationAssertion(rdfs:label "neuroblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (neuroblast development) +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "ISBN:0878932585") "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron.") AnnotationAssertion(rdfs:label "neuroblast development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (primary neural tube formation) +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "ISBN:0878932585") Annotation( "PMID:15327780") "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.") AnnotationAssertion(rdfs:label "primary neural tube formation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (neural rod formation) +AnnotationAssertion(Annotation( "GOC:dh") Annotation( "GOC:ef") "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts.") AnnotationAssertion(rdfs:label "neural rod formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14039,6 +18392,7 @@ SubClassOf( ObjectAllValuesFrom( (neural keel formation) +AnnotationAssertion(Annotation( "GOC:dh") Annotation( "GOC:ef") "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts.") AnnotationAssertion(rdfs:label "neural keel formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14047,6 +18401,7 @@ SubClassOf( ObjectSomeValuesFrom( (notochord formation) +AnnotationAssertion(Annotation( "GOC:dh") Annotation( "GOC:ef") "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.") AnnotationAssertion(rdfs:label "notochord formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14056,6 +18411,7 @@ SubClassOf( ObjectSomeValuesFrom( (neural crest formation) +AnnotationAssertion(Annotation( "GOC:dh") Annotation( "GOC:ef") "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.") AnnotationAssertion(rdfs:label "neural crest formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14063,46 +18419,54 @@ SubClassOf( ObjectSomeValuesFrom( (mesenchymal cell development) +AnnotationAssertion(Annotation( "GOC:dh") Annotation( "GOC:ef") "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.") AnnotationAssertion(rdfs:label "mesenchymal cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (neural crest cell development) +AnnotationAssertion(Annotation( "GOC:dh") Annotation( "GOC:ef") "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.") AnnotationAssertion(rdfs:label "neural crest cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (neural crest cell differentiation) +AnnotationAssertion(Annotation( "GOC:dh") Annotation( "GOC:ef") "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.") AnnotationAssertion(rdfs:label "neural crest cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of neuron maturation) +AnnotationAssertion(Annotation( "GOC:ef") "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.") AnnotationAssertion(rdfs:label "regulation of neuron maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of neuron maturation) +AnnotationAssertion(Annotation( "GOC:ef") "Any process that activates or increases the frequency, rate or extent of neuron maturation.") AnnotationAssertion(rdfs:label "positive regulation of neuron maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of neuron maturation) +AnnotationAssertion(Annotation( "GOC:ef") "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation.") AnnotationAssertion(rdfs:label "negative regulation of neuron maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of norepinephrine secretion) +AnnotationAssertion(Annotation( "GOC:ef") "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine.") AnnotationAssertion(rdfs:label "regulation of norepinephrine secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of serotonin secretion) +AnnotationAssertion(Annotation( "GOC:ef") "Any process that modulates the frequency, rate or extent of the regulated release of serotonin.") AnnotationAssertion(rdfs:label "regulation of serotonin secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14110,6 +18474,7 @@ SubClassOf( (negative regulation of serotonin secretion) +AnnotationAssertion(Annotation( "GOC:ef") "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.") AnnotationAssertion(rdfs:label "negative regulation of serotonin secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14118,6 +18483,7 @@ SubClassOf( (positive regulation of serotonin secretion) +AnnotationAssertion(Annotation( "GOC:ef") "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin.") AnnotationAssertion(rdfs:label "positive regulation of serotonin secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14126,22 +18492,26 @@ SubClassOf( (response to amine) +AnnotationAssertion(Annotation( "GOC:ef") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.") AnnotationAssertion(rdfs:label "response to amine") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (striated muscle tissue development) +AnnotationAssertion(Annotation( "CL:0000737") Annotation( "GOC:dph") Annotation( "GOC:mtg_muscle") "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.") AnnotationAssertion(rdfs:label "striated muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of skeletal muscle adaptation) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.") AnnotationAssertion(rdfs:label "regulation of skeletal muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (skeletal muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.") AnnotationAssertion(rdfs:label "skeletal muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14149,116 +18519,156 @@ SubClassOf( (negative regulation of muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy.") AnnotationAssertion(rdfs:label "negative regulation of muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy.") AnnotationAssertion(rdfs:label "positive regulation of muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "Any process that modulates the frequency, rate or extent of muscle hypertrophy.") AnnotationAssertion(rdfs:label "regulation of muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of muscle adaptation) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "Any process that activates or increases the frequency, rate or extent of muscle adaptation.") AnnotationAssertion(rdfs:label "positive regulation of muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of muscle adaptation) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation.") AnnotationAssertion(rdfs:label "negative regulation of muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (smooth muscle adaptation) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.") AnnotationAssertion(rdfs:label "smooth muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of somitogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "Any process that modulates the frequency, rate or extent of somitogenesis.") AnnotationAssertion(rdfs:label "regulation of somitogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (muscle cell migration) +AnnotationAssertion(Annotation( "CL:0000187") Annotation( "GOC:mtg_muscle") "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism.") AnnotationAssertion(rdfs:label "muscle cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of skeletal muscle contraction) +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "GOC:mtg_muscle") "Any process that modulates the frequency, rate or extent of skeletal muscle contraction.") AnnotationAssertion(rdfs:label "regulation of skeletal muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (phasic smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations.") +AnnotationAssertion(rdfs:label "phasic smooth muscle contraction") +SubClassOf( ) + +# Class: (intestine smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:mtg_muscle") Annotation( "MA:0001539") Annotation( "MSH:D007422") "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine.") +AnnotationAssertion(rdfs:label "intestine smooth muscle contraction") +SubClassOf( ) +SubClassOf( ) + +# Class: (gastro-intestinal system smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:mtg_muscle") Annotation( "MA:0001523") Annotation( "MSH:D041981") "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract).") +AnnotationAssertion(rdfs:label "gastro-intestinal system smooth muscle contraction") +SubClassOf( ) + # Class: (striated muscle cell proliferation) +AnnotationAssertion(Annotation( "CL:0000737") Annotation( "GOC:ef") Annotation( "GOC:mtg_muscle") "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.") AnnotationAssertion(rdfs:label "striated muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (skeletal muscle cell proliferation) +AnnotationAssertion(Annotation( "CL:0000188") Annotation( "GOC:ef") Annotation( "GOC:mtg_muscle") "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population.") AnnotationAssertion(rdfs:label "skeletal muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of skeletal muscle cell proliferation) +AnnotationAssertion(Annotation( "CL:0000188") Annotation( "GOC:ef") Annotation( "GOC:mtg_muscle") "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation.") AnnotationAssertion(rdfs:label "regulation of skeletal muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of skeletal muscle cell proliferation) +AnnotationAssertion(Annotation( "CL:0000188") Annotation( "GOC:ef") Annotation( "GOC:mtg_muscle") "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of skeletal muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of skeletal muscle cell proliferation) +AnnotationAssertion(Annotation( "CL:0000188") Annotation( "GOC:ef") Annotation( "GOC:mtg_muscle") "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of skeletal muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of skeletal muscle contraction via regulation of action potential) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:mtg_muscle") "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes.") AnnotationAssertion(rdfs:label "regulation of skeletal muscle contraction via regulation of action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (skeletal myofibril assembly) +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "GOC:mtg_muscle") "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.") AnnotationAssertion(rdfs:label "skeletal myofibril assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myoblast division) +AnnotationAssertion(Annotation( "CL:0000056") Annotation( "GOC:ef") Annotation( "GOC:mtg_muscle") "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.") AnnotationAssertion(rdfs:label "myoblast division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (response to stimulus involved in regulation of muscle adaptation) +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "GOC:mtg_muscle") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation.") AnnotationAssertion(rdfs:label "response to stimulus involved in regulation of muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cardiac muscle adaptation) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.") AnnotationAssertion(rdfs:label "cardiac muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (striated muscle adaptation) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.") AnnotationAssertion(rdfs:label "striated muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (smooth muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy.") AnnotationAssertion(rdfs:label "smooth muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14266,102 +18676,202 @@ SubClassOf( (muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy.") +AnnotationAssertion( "Wikipedia:Muscle_hypertrophy") AnnotationAssertion(rdfs:label "muscle hypertrophy") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (striated muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.") AnnotationAssertion(rdfs:label "striated muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myotube differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.") AnnotationAssertion(rdfs:label "myotube differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myotube cell development) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.") AnnotationAssertion(rdfs:label "myotube cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (smooth muscle cell migration) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:mtg_muscle") "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism.") AnnotationAssertion(rdfs:label "smooth muscle cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of smooth muscle cell migration) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:mtg_muscle") "Any process that modulates the frequency, rate or extent of smooth muscle cell migration.") AnnotationAssertion(rdfs:label "regulation of smooth muscle cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of smooth muscle cell migration) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:mtg_muscle") "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.") AnnotationAssertion(rdfs:label "positive regulation of smooth muscle cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of smooth muscle cell migration) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:mtg_muscle") "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.") AnnotationAssertion(rdfs:label "negative regulation of smooth muscle cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (monoatomic ion transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:dgf") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of an ion from one side of a membrane to the other.") +AnnotationAssertion(rdfs:label "monoatomic ion transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (bicarbonate transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:ai") "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.") +AnnotationAssertion( "RHEA:28695") +AnnotationAssertion(Annotation(rdfs:label "BESTs transport cytosolic HCO3- to extracellular region") "Reactome:R-HSA-2752067") +AnnotationAssertion(rdfs:label "bicarbonate transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (bile acid transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:ai") "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.") +AnnotationAssertion(Annotation(rdfs:label "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol") "Reactome:R-HSA-194079") +AnnotationAssertion(Annotation(rdfs:label "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol") "Reactome:R-HSA-194083") +AnnotationAssertion(Annotation(rdfs:label "Transport (influx) of bile salts and acids by OATP-A") "Reactome:R-HSA-194130") +AnnotationAssertion(Annotation(rdfs:label "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)") "Reactome:R-HSA-5661184") +AnnotationAssertion(Annotation(rdfs:label "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)") "Reactome:R-HSA-5661198") +AnnotationAssertion(Annotation(rdfs:label "SLC51A:SLC51B transports bile salts from cytosol to extracellular region") "Reactome:R-HSA-9733964") +AnnotationAssertion(rdfs:label "bile acid transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (carbohydrate transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of carbohydrate from one side of a membrane to the other.") +AnnotationAssertion(rdfs:label "carbohydrate transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (hexose transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other.") +AnnotationAssertion(Annotation(rdfs:label "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region") "Reactome:R-HSA-189242") +AnnotationAssertion(Annotation(rdfs:label "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region") "Reactome:R-HSA-5638222") +AnnotationAssertion(rdfs:label "hexose transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (polysaccharide transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.") +AnnotationAssertion(rdfs:label "polysaccharide transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (actin cytoskeleton) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0395825172") Annotation( "ISBN:0815316194") "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.") AnnotationAssertion(rdfs:label "actin cytoskeleton") SubClassOf( ) # Class: (microtubule cytoskeleton) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0395825172") "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.") AnnotationAssertion(rdfs:label "microtubule cytoskeleton") SubClassOf( ) # Class: (gas transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "gas transport") SubClassOf( ) # Class: (oxygen transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "oxygen transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (bicarbonate transport) + +AnnotationAssertion(Annotation( "GOC:krc") "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") +AnnotationAssertion(rdfs:label "bicarbonate transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (monocarboxylic acid transport) + +AnnotationAssertion(Annotation( "GOC:krc") "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") +AnnotationAssertion(rdfs:label "monocarboxylic acid transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (bile acid and bile salt transport) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:krc") Annotation( "PMID:12663868") Annotation( "PMID:14699511") "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") +AnnotationAssertion(rdfs:label "bile acid and bile salt transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (polysaccharide transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.") AnnotationAssertion(rdfs:label "polysaccharide transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (peptide transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "peptide transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (amine transport) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "ISBN:0198506732") "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "amine transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (organic acid transport) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") +AnnotationAssertion(rdfs:label "organic acid transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (organic hydroxy compound transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom.") AnnotationAssertion(rdfs:label "organic hydroxy compound transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein-DNA complex transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "protein-DNA complex transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14369,29 +18879,56 @@ SubClassOf( (norepinephrine transport) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "ISBN:0198506732") "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.") AnnotationAssertion(rdfs:label "norepinephrine transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (nucleobase-containing compound transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "nucleobase-containing compound transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (nucleobase-containing compound transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:ai") "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other.") +AnnotationAssertion(rdfs:label "nucleobase-containing compound transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (energy derivation by oxidation of organic compounds) + +AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released.") +AnnotationAssertion(rdfs:label "energy derivation by oxidation of organic compounds") +SubClassOf( ) + # Class: (membrane) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.") +AnnotationAssertion( "Wikipedia:Biological_membrane") +AnnotationAssertion( "Wikipedia:Transmembrane_protein") AnnotationAssertion(rdfs:label "membrane") SubClassOf( ) DisjointClasses( ) +# Class: (lipid catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.") +AnnotationAssertion( "Wikipedia:Lipid_catabolism") +AnnotationAssertion(rdfs:label "lipid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (cellular component organization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.") AnnotationAssertion(rdfs:label "cellular component organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cell growth) +AnnotationAssertion(Annotation( "GOC:ai") "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.") AnnotationAssertion(rdfs:label "cell growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14399,45 +18936,77 @@ SubClassOf( (vesicle organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.") AnnotationAssertion(rdfs:label "vesicle organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (carbohydrate biosynthetic process) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.") AnnotationAssertion(rdfs:label "carbohydrate biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (carbohydrate catabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.") +AnnotationAssertion(rdfs:label "carbohydrate catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (organic acid biosynthetic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.") +AnnotationAssertion(rdfs:label "organic acid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (organic acid catabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.") +AnnotationAssertion(rdfs:label "organic acid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (regulation of membrane potential in photoreceptor cell) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:hb") Annotation( "GOC:tb") "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon.") AnnotationAssertion(rdfs:label "regulation of membrane potential in photoreceptor cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (RNA metabolic process) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.") AnnotationAssertion(rdfs:label "RNA metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (vesicle-mediated transport) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mah") Annotation( "ISBN:08789310662000") "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.") AnnotationAssertion(rdfs:label "vesicle-mediated transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of striated muscle tissue development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of striated muscle development.") AnnotationAssertion(rdfs:label "regulation of striated muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (female meiosis chromosome segregation) +AnnotationAssertion(Annotation( "GOC:ai") "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.") AnnotationAssertion(rdfs:label "female meiosis chromosome segregation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (oocyte microtubule cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:mtg_sensu") Annotation( "PMID:11231123") "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster.") AnnotationAssertion(rdfs:label "oocyte microtubule cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14445,12 +19014,15 @@ SubClassOf( ObjectSomeValuesFrom( (morphogenesis of embryonic epithelium) +AnnotationAssertion(Annotation( "GOC:jl") "The process in which the anatomical structures of embryonic epithelia are generated and organized.") AnnotationAssertion(rdfs:label "morphogenesis of embryonic epithelium") SubClassOf( ) SubClassOf( ) # Class: (cell migration) +AnnotationAssertion(Annotation( "GOC:cjm") Annotation( "GOC:dph") Annotation( "GOC:ems") Annotation( "GOC:pf") Annotation( "Wikipedia:Cell_migration") "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.") +AnnotationAssertion( "Wikipedia:Cell_migration") AnnotationAssertion(rdfs:label "cell migration") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -14459,6 +19031,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (negative regulation of angiogenesis) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.") AnnotationAssertion(rdfs:label "negative regulation of angiogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14466,6 +19039,8 @@ SubClassOf( (sarcoplasm) +AnnotationAssertion(Annotation( "ISBN:0198547684") "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.") +AnnotationAssertion( "Wikipedia:Sarcoplasm") AnnotationAssertion(rdfs:label "sarcoplasm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14473,25 +19048,55 @@ SubClassOf( ObjectComplementOf(Object SubClassOf( ObjectSomeValuesFrom( ObjectComplementOf())) DisjointClasses( ObjectSomeValuesFrom( )) +# Class: (hydrolase activity) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.") +AnnotationAssertion( "EC:3.-.-.-") +AnnotationAssertion(Annotation(rdfs:label "Partial proteolysis of antigen in phagolysosomes") "Reactome:R-HSA-1236938") +AnnotationAssertion(Annotation(rdfs:label "Production of AA by iPLA2 upon FCGR activation") "Reactome:R-HSA-2029475") +AnnotationAssertion(Annotation(rdfs:label "ABHD4 hydrolyses NAPE") "Reactome:R-HSA-5694583") +AnnotationAssertion(Annotation(rdfs:label "ABHD14B hydrolyses PNPB") "Reactome:R-HSA-5695964") +AnnotationAssertion(Annotation(rdfs:label "CMBL hydrolyses OM to OLMS") "Reactome:R-HSA-6786190") +AnnotationAssertion(Annotation(rdfs:label "HDHD1:Mg2+ dephosphorylates PURIDP") "Reactome:R-HSA-6788295") +AnnotationAssertion(Annotation(rdfs:label "ENPPs hydrolyse CoA-SH to PPANT, PAP") "Reactome:R-HSA-8938314") +AnnotationAssertion(Annotation(rdfs:label "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate") "Reactome:R-HSA-8952137") +AnnotationAssertion(rdfs:label "hydrolase activity") +SubClassOf( ) + +# Class: (hydrolase activity, acting on ester bonds) + +AnnotationAssertion(Annotation( "GOC:jl") "Catalysis of the hydrolysis of any ester bond.") +AnnotationAssertion( "EC:3.1.-.-") +AnnotationAssertion(Annotation(rdfs:label "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid") "Reactome:R-HSA-162729") +AnnotationAssertion(Annotation(rdfs:label "Butyrylcholinesterase hydrolyzes acyl Ghrelin") "Reactome:R-HSA-9023617") +AnnotationAssertion(Annotation(rdfs:label "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin") "Reactome:R-HSA-9023619") +AnnotationAssertion(Annotation(rdfs:label "BCHE hydrolyzes ASA-") "Reactome:R-HSA-9749609") +AnnotationAssertion(rdfs:label "hydrolase activity, acting on ester bonds") +SubClassOf( ) + # Class: (nucleologenesis) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells.") AnnotationAssertion(rdfs:label "nucleologenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (stem cell division) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "ISBN:0582227089") "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.") AnnotationAssertion(rdfs:label "stem cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of translation) +AnnotationAssertion(Annotation( "GOC:isa_complete") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.") AnnotationAssertion(rdfs:label "negative regulation of translation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of exocytosis) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of exocytosis.") AnnotationAssertion(rdfs:label "regulation of exocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14499,28 +19104,48 @@ SubClassOf( (phenol-containing compound metabolic process) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.") +AnnotationAssertion( "UM-BBD_pathwayID:phe") +AnnotationAssertion(rdfs:comment "Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds.") AnnotationAssertion(rdfs:label "phenol-containing compound metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (reproductive behavior) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:pr") "The specific behavior of an organism that is associated with reproduction.") +AnnotationAssertion(rdfs:label "reproductive behavior") +EquivalentClasses( ObjectIntersectionOf( )) + # Class: (regulation of lipid metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.") AnnotationAssertion(rdfs:label "regulation of lipid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (regulation of steroid metabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.") +AnnotationAssertion(rdfs:label "regulation of steroid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (regulation of nucleobase-containing compound metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.") AnnotationAssertion(rdfs:label "regulation of nucleobase-containing compound metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.") AnnotationAssertion(rdfs:label "regulation of metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (transmission of nerve impulse) +AnnotationAssertion(Annotation( "GOC:curators") Annotation( "ISBN:0815316194") "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.") AnnotationAssertion(rdfs:label "transmission of nerve impulse") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -14529,6 +19154,7 @@ SubClassOf( ObjectSomeValuesFrom( (neuronal action potential) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") Annotation( "GOC:tb") "An action potential that occurs in a neuron.") AnnotationAssertion(rdfs:label "neuronal action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14536,40 +19162,91 @@ SubClassOf( ObjectSomeValuesFrom( (sensory perception of pain) +AnnotationAssertion(Annotation( "GOC:curators") "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.") +AnnotationAssertion( "Wikipedia:Nociception") AnnotationAssertion(rdfs:label "sensory perception of pain") SubClassOf( ) +# Class: (hexose metabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.") +AnnotationAssertion(rdfs:label "hexose metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (hexose biosynthetic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.") +AnnotationAssertion(rdfs:label "hexose biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (hexose catabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.") +AnnotationAssertion(rdfs:label "hexose catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (phenol-containing compound catabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.") +AnnotationAssertion( "MetaCyc:PHENOLDEG-PWY") +AnnotationAssertion(rdfs:label "phenol-containing compound catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (protein metabolic process) +AnnotationAssertion(Annotation( "GOC:ma") "The chemical reactions and pathways involving a protein. Includes protein modification.") +AnnotationAssertion( "Wikipedia:Protein_metabolism") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "protein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (catechol-containing compound catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.") +AnnotationAssertion(rdfs:label "catechol-containing compound catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (cellular homeostasis) +AnnotationAssertion(Annotation( "GOC:isa_complete") Annotation( "GOC:jl") Annotation( "ISBN:0395825172") "Any process involved in the maintenance of an internal steady state at the level of the cell.") AnnotationAssertion(rdfs:label "cellular homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectAllValuesFrom( )) DisjointClasses( ) +# Class: (carboxylic acid metabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).") +AnnotationAssertion(rdfs:label "carboxylic acid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (outer membrane) +AnnotationAssertion(Annotation( "GOC:go_curators") "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.") AnnotationAssertion(rdfs:label "outer membrane") SubClassOf( ) # Class: (antigen processing and presentation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") Annotation( "PMID:15771591") Annotation( "PMID:15928678") "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.") +AnnotationAssertion( "Wikipedia:Antigen_presentation") AnnotationAssertion(rdfs:label "antigen processing and presentation") SubClassOf( ) # Class: (sexual reproduction) +AnnotationAssertion(Annotation( "Wikipedia:Sexual_reproduction") "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).") +AnnotationAssertion( "Wikipedia:Sexual_reproduction") +AnnotationAssertion(rdfs:comment "Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.") AnnotationAssertion(rdfs:label "sexual reproduction") SubClassOf( ) # Class: (prechordal plate formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.") AnnotationAssertion(rdfs:label "prechordal plate formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14578,6 +19255,7 @@ SubClassOf( ObjectSomeValuesFrom( (spinal cord development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.") AnnotationAssertion(rdfs:label "spinal cord development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14585,6 +19263,7 @@ SubClassOf( ObjectSomeValuesFrom( (ventral spinal cord interneuron differentiation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "PMID:11262869") "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.") AnnotationAssertion(rdfs:label "ventral spinal cord interneuron differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14593,6 +19272,7 @@ SubClassOf( ObjectSomeValuesFrom( (cell differentiation in spinal cord) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "PMID:11262869") "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.") AnnotationAssertion(rdfs:label "cell differentiation in spinal cord") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14600,6 +19280,7 @@ SubClassOf( ObjectSomeValuesFrom( (ventral spinal cord development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.") AnnotationAssertion(rdfs:label "ventral spinal cord development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14607,6 +19288,7 @@ SubClassOf( ObjectSomeValuesFrom( (spinal cord motor neuron differentiation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "PMID:11262869") "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.") AnnotationAssertion(rdfs:label "spinal cord motor neuron differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14615,12 +19297,14 @@ SubClassOf( ObjectSomeValuesFrom( (neural tube patterning) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.") AnnotationAssertion(rdfs:label "neural tube patterning") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cell differentiation in hindbrain) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.") AnnotationAssertion(rdfs:label "cell differentiation in hindbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14630,6 +19314,7 @@ SubClassOf( ObjectAllValuesFrom( (cell proliferation in hindbrain) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain.") AnnotationAssertion(rdfs:label "cell proliferation in hindbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14639,6 +19324,7 @@ SubClassOf( ObjectAllValuesFrom( (cell migration in hindbrain) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The orderly movement of a cell that will reside in the hindbrain.") AnnotationAssertion(rdfs:label "cell migration in hindbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14648,12 +19334,14 @@ SubClassOf( ObjectAllValuesFrom( (cranial nerve development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.") AnnotationAssertion(rdfs:label "cranial nerve development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (rhombomere development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.") AnnotationAssertion(rdfs:label "rhombomere development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14661,6 +19349,7 @@ SubClassOf( ObjectSomeValuesFrom( (midbrain-hindbrain boundary initiation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:isa_complete") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "PMID:15541513") "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.") AnnotationAssertion(rdfs:label "midbrain-hindbrain boundary initiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14669,6 +19358,7 @@ SubClassOf( ObjectSomeValuesFrom( (pons development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.") AnnotationAssertion(rdfs:label "pons development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14676,6 +19366,7 @@ SubClassOf( ObjectSomeValuesFrom( (medulla oblongata development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.") AnnotationAssertion(rdfs:label "medulla oblongata development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14684,6 +19375,7 @@ SubClassOf( ObjectSomeValuesFrom( (central nervous system morphogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0582227089") "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.") AnnotationAssertion(rdfs:label "central nervous system morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14692,6 +19384,7 @@ SubClassOf( ObjectSomeValuesFrom( (midbrain-hindbrain boundary morphogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "PMID:15541513") "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.") AnnotationAssertion(rdfs:label "midbrain-hindbrain boundary morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14699,6 +19392,7 @@ SubClassOf( ObjectSomeValuesFrom( (central nervous system formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0582227089") "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.") AnnotationAssertion(rdfs:label "central nervous system formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14707,12 +19401,14 @@ SubClassOf( ObjectSomeValuesFrom( (trigeminal nerve development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.") AnnotationAssertion(rdfs:label "trigeminal nerve development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (hindbrain morphogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.") AnnotationAssertion(rdfs:label "hindbrain morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14721,6 +19417,7 @@ SubClassOf( ObjectSomeValuesFrom( (hindbrain formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.") AnnotationAssertion(rdfs:label "hindbrain formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14729,6 +19426,7 @@ SubClassOf( ObjectSomeValuesFrom( (hindbrain maturation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.") AnnotationAssertion(rdfs:label "hindbrain maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14737,6 +19435,7 @@ SubClassOf( ObjectSomeValuesFrom( (medulla oblongata morphogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.") AnnotationAssertion(rdfs:label "medulla oblongata morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14746,6 +19445,7 @@ SubClassOf( ObjectSomeValuesFrom( (medulla oblongata formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.") AnnotationAssertion(rdfs:label "medulla oblongata formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14755,6 +19455,7 @@ SubClassOf( ObjectSomeValuesFrom( (medulla oblongata maturation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.") AnnotationAssertion(rdfs:label "medulla oblongata maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14763,6 +19464,7 @@ SubClassOf( ObjectSomeValuesFrom( (pons morphogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.") AnnotationAssertion(rdfs:label "pons morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14772,6 +19474,7 @@ SubClassOf( ObjectSomeValuesFrom( (pons formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.") AnnotationAssertion(rdfs:label "pons formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14781,6 +19484,7 @@ SubClassOf( ObjectSomeValuesFrom( (pons maturation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.") AnnotationAssertion(rdfs:label "pons maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14789,6 +19493,7 @@ SubClassOf( ObjectSomeValuesFrom( (rhombomere morphogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.") AnnotationAssertion(rdfs:label "rhombomere morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14797,6 +19502,7 @@ SubClassOf( ObjectSomeValuesFrom( (rhombomere formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.") AnnotationAssertion(rdfs:label "rhombomere formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14805,6 +19511,7 @@ SubClassOf( ObjectSomeValuesFrom( (cranial nerve morphogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.") AnnotationAssertion(rdfs:label "cranial nerve morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14813,6 +19520,7 @@ SubClassOf( ObjectSomeValuesFrom( (cranial nerve formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.") AnnotationAssertion(rdfs:label "cranial nerve formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14821,6 +19529,7 @@ SubClassOf( ObjectSomeValuesFrom( (cranial nerve maturation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.") AnnotationAssertion(rdfs:label "cranial nerve maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14828,6 +19537,7 @@ SubClassOf( ObjectSomeValuesFrom( (central nervous system maturation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0582227089") "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.") AnnotationAssertion(rdfs:label "central nervous system maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14835,6 +19545,7 @@ SubClassOf( ObjectSomeValuesFrom( (trigeminal nerve maturation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.") AnnotationAssertion(rdfs:label "trigeminal nerve maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14842,6 +19553,7 @@ SubClassOf( ObjectSomeValuesFrom( (trigeminal nerve morphogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.") AnnotationAssertion(rdfs:label "trigeminal nerve morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14849,6 +19561,7 @@ SubClassOf( ObjectSomeValuesFrom( (trigeminal nerve formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.") AnnotationAssertion(rdfs:label "trigeminal nerve formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14856,6 +19569,7 @@ SubClassOf( ObjectSomeValuesFrom( (rhombomere boundary formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.") AnnotationAssertion(rdfs:label "rhombomere boundary formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14863,6 +19577,7 @@ SubClassOf( ObjectSomeValuesFrom( (nerve development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "nerve development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14871,6 +19586,7 @@ SubClassOf( ObjectSomeValuesFrom( (nerve maturation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state.") AnnotationAssertion(rdfs:label "nerve maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14878,11 +19594,13 @@ SubClassOf( ObjectSomeValuesFrom( (developmental maturation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.") AnnotationAssertion(rdfs:label "developmental maturation") SubClassOf( ) # Class: (locus ceruleus development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.") AnnotationAssertion(rdfs:label "locus ceruleus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14891,6 +19609,7 @@ SubClassOf( ObjectSomeValuesFrom( (locus ceruleus morphogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.") AnnotationAssertion(rdfs:label "locus ceruleus morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14900,6 +19619,7 @@ SubClassOf( ObjectSomeValuesFrom( (locus ceruleus formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.") AnnotationAssertion(rdfs:label "locus ceruleus formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14909,6 +19629,7 @@ SubClassOf( ObjectSomeValuesFrom( (locus ceruleus maturation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.") AnnotationAssertion(rdfs:label "locus ceruleus maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14917,6 +19638,7 @@ SubClassOf( ObjectSomeValuesFrom( (superior olivary nucleus development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.") AnnotationAssertion(rdfs:label "superior olivary nucleus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14924,6 +19646,7 @@ SubClassOf( ObjectSomeValuesFrom( (superior olivary nucleus morphogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.") AnnotationAssertion(rdfs:label "superior olivary nucleus morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14933,6 +19656,7 @@ SubClassOf( ObjectSomeValuesFrom( (superior olivary nucleus formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.") AnnotationAssertion(rdfs:label "superior olivary nucleus formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14942,6 +19666,7 @@ SubClassOf( ObjectSomeValuesFrom( (superior olivary nucleus maturation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0838580343") "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.") AnnotationAssertion(rdfs:label "superior olivary nucleus maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14950,6 +19675,7 @@ SubClassOf( ObjectSomeValuesFrom( (midbrain-hindbrain boundary maturation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "PMID:15541513") "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.") AnnotationAssertion(rdfs:label "midbrain-hindbrain boundary maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14957,6 +19683,7 @@ SubClassOf( ObjectSomeValuesFrom( (salivary nucleus development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:curators") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "salivary nucleus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14964,12 +19691,14 @@ SubClassOf( ObjectSomeValuesFrom( (superior salivary nucleus development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:curators") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "superior salivary nucleus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (glial cell development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.") AnnotationAssertion(rdfs:label "glial cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14977,12 +19706,14 @@ SubClassOf( ObjectSomeValuesFrom( (rostrocaudal neural tube patterning) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "PMID:11262869") "The process in which the neural tube is divided into specific regions along the rostrocaudal axis.") AnnotationAssertion(rdfs:label "rostrocaudal neural tube patterning") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (hindbrain-spinal cord boundary formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "PMID:11262869") "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary.") AnnotationAssertion(rdfs:label "hindbrain-spinal cord boundary formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -14990,6 +19721,7 @@ SubClassOf( ObjectSomeValuesFrom( (neural tube development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.") AnnotationAssertion(rdfs:label "neural tube development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15001,6 +19733,7 @@ SubClassOf( ObjectSomeValuesFrom( (central nervous system neuron differentiation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.") AnnotationAssertion(rdfs:label "central nervous system neuron differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15008,6 +19741,7 @@ SubClassOf( ObjectSomeValuesFrom( (central nervous system neuron development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.") AnnotationAssertion(rdfs:label "central nervous system neuron development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15015,6 +19749,7 @@ SubClassOf( ObjectSomeValuesFrom( (neural plate formation) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0878932437") Annotation( "ISBN:0878932585") Annotation( "PMID:15806586") "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.") AnnotationAssertion(rdfs:label "neural plate formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15023,24 +19758,29 @@ SubClassOf( ObjectSomeValuesFrom( (neural plate anterior/posterior regionalization) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.") AnnotationAssertion(rdfs:label "neural plate anterior/posterior regionalization") SubClassOf( ) SubClassOf( ) # Class: (neurogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:curators") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "Generation of cells within the nervous system.") +AnnotationAssertion( "Wikipedia:Neurogenesis") AnnotationAssertion(rdfs:label "neurogenesis") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (central nervous system vasculogenesis) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.") AnnotationAssertion(rdfs:label "central nervous system vasculogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (rhombomere cell migration) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "PMID:15629700") "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere.") AnnotationAssertion(rdfs:label "rhombomere cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15048,6 +19788,7 @@ SubClassOf( ObjectSomeValuesFrom( (metencephalon development) +AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:curators") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "metencephalon development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15056,22 +19797,26 @@ SubClassOf( ObjectSomeValuesFrom( (cell cycle process) +AnnotationAssertion(Annotation( "GOC:isa_complete") Annotation( "GOC:mtg_cell_cycle") "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.") AnnotationAssertion(rdfs:label "cell cycle process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (membrane docking) +AnnotationAssertion(Annotation( "GOC:isa_complete") Annotation( "PMID:27875684") "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.") AnnotationAssertion(rdfs:label "membrane docking") SubClassOf( ) # Class: (regulation of cell-cell adhesion) +AnnotationAssertion(Annotation( "GOC:isa_complete") "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.") AnnotationAssertion(rdfs:label "regulation of cell-cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of cell-cell adhesion) +AnnotationAssertion(Annotation( "GOC:isa_complete") "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.") AnnotationAssertion(rdfs:label "negative regulation of cell-cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15079,6 +19824,7 @@ SubClassOf( (positive regulation of cell-cell adhesion) +AnnotationAssertion(Annotation( "GOC:isa_complete") "Any process that activates or increases the rate or extent of cell adhesion to another cell.") AnnotationAssertion(rdfs:label "positive regulation of cell-cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15086,6 +19832,8 @@ SubClassOf( (cellular component disassembly) +AnnotationAssertion(Annotation( "GOC:isa_complete") "A cellular process that results in the breakdown of a cellular component.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "cellular component disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15094,34 +19842,41 @@ DisjointClasses( (cellular process involved in reproduction in multicellular organism) +AnnotationAssertion(Annotation( "GOC:isa_complete") "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.") AnnotationAssertion(rdfs:label "cellular process involved in reproduction in multicellular organism") EquivalentClasses( ObjectIntersectionOf( )) SubClassOf( ) # Class: (reproductive process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.") +AnnotationAssertion( "Wikipedia:Reproduction") AnnotationAssertion(rdfs:label "reproductive process") SubClassOf( ) # Class: (digestive system process) +AnnotationAssertion(Annotation( "GOC:isa_complete") Annotation( "GOC:jid") Annotation( "GOC:mtg_cardio") "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.") AnnotationAssertion(rdfs:label "digestive system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of anatomical structure morphogenesis) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.") AnnotationAssertion(rdfs:label "regulation of anatomical structure morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of cell morphogenesis) +AnnotationAssertion(Annotation( "GOC:isa_complete") "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.") AnnotationAssertion(rdfs:label "regulation of cell morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular component assembly) +AnnotationAssertion(Annotation( "GOC:isa_complete") "The aggregation, arrangement and bonding together of a cellular component.") AnnotationAssertion(rdfs:label "cellular component assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15129,6 +19884,7 @@ SubClassOf( ObjectSomeValuesFrom( (gland morphogenesis) +AnnotationAssertion(Annotation( "GOC:isa_complete") "The process in which the anatomical structures of a gland are generated and organized.") AnnotationAssertion(rdfs:label "gland morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15137,40 +19893,75 @@ SubClassOf( ObjectSomeValuesFrom( (ribonucleoprotein complex biogenesis) +AnnotationAssertion(Annotation( "GOC:isa_complete") Annotation( "GOC:mah") "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex.") AnnotationAssertion(rdfs:label "ribonucleoprotein complex biogenesis") SubClassOf( ) # Class: (extracellular matrix disassembly) +AnnotationAssertion(Annotation( "GOC:jid") "A process that results in the breakdown of the extracellular matrix.") AnnotationAssertion(rdfs:label "extracellular matrix disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein-RNA complex assembly) +AnnotationAssertion(Annotation( "GOC:jl") "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.") AnnotationAssertion(rdfs:label "protein-RNA complex assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.") +AnnotationAssertion(Annotation(rdfs:label "Egress of internalized antigen to the cytosol via sec61") "Reactome:R-HSA-1236947") +AnnotationAssertion(Annotation(rdfs:label "SLC2A9 transports Fru, Glc, urate") "Reactome:R-HSA-429036") +AnnotationAssertion(Annotation(rdfs:label "MATEs mediate extrusion of xenobiotics") "Reactome:R-HSA-434650") +AnnotationAssertion(Annotation(rdfs:label "Defective SLC2A9 does not transport Fru, Glc, urate") "Reactome:R-HSA-5638209") +AnnotationAssertion(Annotation(rdfs:label "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA") "Reactome:R-HSA-5671707") +AnnotationAssertion(Annotation(rdfs:label "An unknown carrier transports cytosolic glyoxylate to the peroxisome") "Reactome:R-HSA-6784434") +AnnotationAssertion(Annotation(rdfs:label "An unknown carrier transports mitochondrial glyoxylate to the cytosol") "Reactome:R-HSA-6784436") +AnnotationAssertion(rdfs:label "transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (macromolecule transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of a macromolecule from one side of a membrane to the other.") +AnnotationAssertion(rdfs:label "macromolecule transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (regulation of transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_cardio") Annotation( "GOC:mtg_transport") "Any process that modulates the frequency, rate or extent of transmembrane transporter activity.") +AnnotationAssertion(rdfs:label "regulation of transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (signal transduction involved in regulation of gene expression) +AnnotationAssertion(Annotation( "GOC:mtg_signal") "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.") AnnotationAssertion(rdfs:label "signal transduction involved in regulation of gene expression") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of signaling) +AnnotationAssertion(Annotation( "GOC:mtg_signal") "Any process that modulates the frequency, rate or extent of a signaling process.") AnnotationAssertion(rdfs:label "regulation of signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (signaling) +AnnotationAssertion(Annotation( "GOC:mtg_signal") Annotation( "GOC:mtg_signaling_feb11") Annotation( "GOC:signaling") "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.") +AnnotationAssertion(rdfs:comment "Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.") AnnotationAssertion(rdfs:label "signaling") SubClassOf( ) # Class: (positive regulation of signaling) +AnnotationAssertion(Annotation( "GOC:mtg_signal") "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.") AnnotationAssertion(rdfs:label "positive regulation of signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15179,6 +19970,7 @@ SubClassOf( ObjectSomeValuesFrom( (negative regulation of signaling) +AnnotationAssertion(Annotation( "GOC:mtg_signal") "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.") AnnotationAssertion(rdfs:label "negative regulation of signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15187,23 +19979,29 @@ SubClassOf( ObjectSomeValuesFrom( (signal release) +AnnotationAssertion(Annotation( "GOC:mtg_signal") "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.") AnnotationAssertion(rdfs:label "signal release") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (establishment of cell polarity) +AnnotationAssertion(Annotation( "GOC:mah") "The specification and formation of anisotropic intracellular organization or cell growth patterns.") AnnotationAssertion(rdfs:label "establishment of cell polarity") SubClassOf( ) # Class: (myofibril) +AnnotationAssertion(Annotation( "ISBN:0815316194") "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.") +AnnotationAssertion( "Wikipedia:Myofibril") AnnotationAssertion(rdfs:label "myofibril") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (sarcomere) +AnnotationAssertion(Annotation( "ISBN:0815316194") "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.") +AnnotationAssertion( "Wikipedia:Sarcomere") AnnotationAssertion(rdfs:label "sarcomere") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -15211,42 +20009,49 @@ SubClassOf( ObjectSomeValuesFrom( (actin filament-based process) +AnnotationAssertion(Annotation( "GOC:mah") "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.") AnnotationAssertion(rdfs:label "actin filament-based process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cell projection organization) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mah") Annotation( "PMID:16318917") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.") AnnotationAssertion(rdfs:label "cell projection organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cell projection assembly) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mah") Annotation( "PMID:18391171") "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.") AnnotationAssertion(rdfs:label "cell projection assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (microvillus assembly) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.") AnnotationAssertion(rdfs:label "microvillus assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (actin cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.") AnnotationAssertion(rdfs:label "actin cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (actin filament-based movement) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.") AnnotationAssertion(rdfs:label "actin filament-based movement") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vesicle transport along actin filament) +AnnotationAssertion(Annotation( "GOC:mah") "Movement of a vesicle along an actin filament, mediated by motor proteins.") AnnotationAssertion(rdfs:label "vesicle transport along actin filament") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15254,6 +20059,8 @@ SubClassOf( (cell junction) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "GOC:mah") Annotation( "ISBN:0198506732") Annotation( "PMID:26820516") Annotation( "PMID:28096264") "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.") +AnnotationAssertion( "Wikipedia:Cell_junction") AnnotationAssertion(rdfs:label "cell junction") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -15262,13 +20069,26 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (peptide hormone secretion) +AnnotationAssertion(Annotation( "GOC:mah") "The regulated release of a peptide hormone from a cell.") AnnotationAssertion(rdfs:label "peptide hormone secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (insulin secretion) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.") +AnnotationAssertion(rdfs:label "insulin secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) + # Class: (hemopoiesis) +AnnotationAssertion(Annotation( "GOC:dgh") Annotation( "ISBN:0198506732") "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.") +AnnotationAssertion( "Wikipedia:Haematopoiesis") AnnotationAssertion(rdfs:label "hemopoiesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -15276,6 +20096,8 @@ SubClassOf( ObjectAllValuesFrom( (lymphocyte differentiation) +AnnotationAssertion(Annotation( "CL:0000542") Annotation( "GOC:go_curators") "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.") +AnnotationAssertion(rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.") AnnotationAssertion(rdfs:label "lymphocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15283,6 +20105,7 @@ SubClassOf( (myeloid cell differentiation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.") AnnotationAssertion(rdfs:label "myeloid cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15290,18 +20113,24 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of endocytosis) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of endocytosis.") AnnotationAssertion(rdfs:label "regulation of endocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (transport vesicle) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:22160157") "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.") +AnnotationAssertion( "NIF_Subcellular:sao885490876") +AnnotationAssertion(rdfs:comment "Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'.") AnnotationAssertion(rdfs:label "transport vesicle") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (secretory granule) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.") +AnnotationAssertion(rdfs:comment "Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'.") AnnotationAssertion(rdfs:label "secretory granule") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -15312,18 +20141,30 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (cell differentiation) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.") +AnnotationAssertion( "Wikipedia:Cellular_differentiation") AnnotationAssertion(rdfs:label "cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of cell adhesion) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.") AnnotationAssertion(rdfs:label "regulation of cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (protein catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.") +AnnotationAssertion( "Wikipedia:Protein_catabolism") +AnnotationAssertion(rdfs:comment "This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.") +AnnotationAssertion(rdfs:label "protein catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (neuron differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "The process in which a relatively unspecialized cell acquires specialized features of a neuron.") AnnotationAssertion(rdfs:label "neuron differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15331,12 +20172,14 @@ SubClassOf( ObjectSomeValuesFrom( (extracellular matrix organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.") AnnotationAssertion(rdfs:label "extracellular matrix organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (collagen fibril organization) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.") AnnotationAssertion(rdfs:label "collagen fibril organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15346,21 +20189,33 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (glycosaminoglycan metabolic process) +AnnotationAssertion(Annotation( "ISBN:0192800981") "The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.") AnnotationAssertion(rdfs:label "glycosaminoglycan metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (hyaluronan metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.") AnnotationAssertion(rdfs:label "hyaluronan metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (hyaluronan biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.") AnnotationAssertion(rdfs:label "hyaluronan biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (hyaluronan catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.") +AnnotationAssertion( "MetaCyc:PWY-7645") +AnnotationAssertion(rdfs:label "hyaluronan catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (T cell differentiation) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mah") Annotation( "GO_REF:0000022") "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.") +AnnotationAssertion(rdfs:comment "Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.") AnnotationAssertion(rdfs:label "T cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15368,6 +20223,8 @@ SubClassOf( (erythrocyte differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.") +AnnotationAssertion( "Wikipedia:Erythropoiesis") AnnotationAssertion(rdfs:label "erythrocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15375,24 +20232,28 @@ SubClassOf( ObjectSomeValuesFrom( (megakaryocyte differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.") AnnotationAssertion(rdfs:label "megakaryocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (monocyte differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.") AnnotationAssertion(rdfs:label "monocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (macrophage differentiation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.") AnnotationAssertion(rdfs:label "macrophage differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myofibril assembly) +AnnotationAssertion(Annotation( "GOC:mah") "Formation of myofibrils, the repeating units of striated muscle.") AnnotationAssertion(rdfs:label "myofibril assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15401,32 +20262,39 @@ SubClassOf( ObjectSomeValuesFrom( (chromosome condensation) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.") AnnotationAssertion(rdfs:label "chromosome condensation") SubClassOf( ) # Class: (apoptotic nuclear changes) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.") AnnotationAssertion(rdfs:label "apoptotic nuclear changes") SubClassOf( ) # Class: (apoptotic chromosome condensation) +AnnotationAssertion(Annotation( "GOC:mah") "The compaction of chromatin during apoptosis.") +AnnotationAssertion( "Wikipedia:Pyknosis") AnnotationAssertion(rdfs:label "apoptotic chromosome condensation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (nuclear fragmentation involved in apoptotic nuclear change) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") Annotation( "ISBN:0721639976") "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.") AnnotationAssertion(rdfs:label "nuclear fragmentation involved in apoptotic nuclear change") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of ossification) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.") AnnotationAssertion(rdfs:label "regulation of ossification") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of ossification) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.") AnnotationAssertion(rdfs:label "negative regulation of ossification") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15434,6 +20302,7 @@ SubClassOf( (positive regulation of cell growth) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate, extent or direction of cell growth.") AnnotationAssertion(rdfs:label "positive regulation of cell growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15442,6 +20311,7 @@ SubClassOf( (negative regulation of cell growth) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.") AnnotationAssertion(rdfs:label "negative regulation of cell growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15450,6 +20320,8 @@ SubClassOf( (external encapsulating structure) +AnnotationAssertion(Annotation( "GOC:go_curators") "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.") +AnnotationAssertion(rdfs:comment "The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.") AnnotationAssertion(rdfs:label "external encapsulating structure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -15457,12 +20329,14 @@ SubClassOf( ObjectSomeValuesFrom( (osteoclast differentiation) +AnnotationAssertion(Annotation( "CL:0000092") Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:12161749") "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.") AnnotationAssertion(rdfs:label "osteoclast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (respiratory tube development) +AnnotationAssertion(Annotation( "GOC:jid") "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.") AnnotationAssertion(rdfs:label "respiratory tube development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15471,6 +20345,7 @@ SubClassOf( (lung development) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "UBERON:0002048") "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.") AnnotationAssertion(rdfs:label "lung development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15480,6 +20355,7 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of cell migration) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of cell migration.") AnnotationAssertion(rdfs:label "regulation of cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15489,6 +20365,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (positive regulation of cell migration) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of cell migration.") AnnotationAssertion(rdfs:label "positive regulation of cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15496,6 +20373,7 @@ SubClassOf( (negative regulation of cell migration) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.") AnnotationAssertion(rdfs:label "negative regulation of cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15503,23 +20381,55 @@ SubClassOf( (membrane disassembly) +AnnotationAssertion(Annotation( "GOC:mah") "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy.") AnnotationAssertion(rdfs:label "membrane disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (defecation) + +AnnotationAssertion(Annotation( "GOC:mah") "The expulsion of feces from the rectum.") +AnnotationAssertion( "Wikipedia:Defecation") +AnnotationAssertion(rdfs:label "defecation") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (peristalsis) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.") +AnnotationAssertion( "Wikipedia:Peristalsis") +AnnotationAssertion(rdfs:label "peristalsis") +SubClassOf( ) + # Class: (nuclear migration along microtubule) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:sgd_curators") "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.") AnnotationAssertion(rdfs:label "nuclear migration along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (smooth muscle contractile fiber) +AnnotationAssertion(Annotation( "GOC:mah") "The contractile fiber of smooth muscle cells.") AnnotationAssertion(rdfs:label "smooth muscle contractile fiber") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (bile acid catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.") +AnnotationAssertion(rdfs:label "bile acid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (collagen catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.") +AnnotationAssertion(rdfs:label "collagen catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (leukocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:jl") "The movement of a leukocyte in response to an external stimulus.") AnnotationAssertion(rdfs:label "leukocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15527,6 +20437,7 @@ SubClassOf( (transport vesicle membrane) +AnnotationAssertion(Annotation( "GOC:mah") "The lipid bilayer surrounding a transport vesicle.") AnnotationAssertion(rdfs:label "transport vesicle membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15534,18 +20445,21 @@ SubClassOf( ObjectSomeValuesFrom( (cytoplasmic vesicle membrane) +AnnotationAssertion(Annotation( "GOC:mah") "The lipid bilayer surrounding a cytoplasmic vesicle.") AnnotationAssertion(rdfs:label "cytoplasmic vesicle membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (Golgi-associated vesicle membrane) +AnnotationAssertion(Annotation( "GOC:mah") "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.") AnnotationAssertion(rdfs:label "Golgi-associated vesicle membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (secretory granule membrane) +AnnotationAssertion(Annotation( "GOC:mah") "The lipid bilayer surrounding a secretory granule.") AnnotationAssertion(rdfs:label "secretory granule membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15553,11 +20467,13 @@ SubClassOf( ObjectSomeValuesFrom( (cytoskeleton-dependent intracellular transport) +AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.") AnnotationAssertion(rdfs:label "cytoskeleton-dependent intracellular transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (oocyte localization involved in germarium-derived egg chamber formation) +AnnotationAssertion(Annotation( "GOC:mtg_sensu") Annotation( "PMID:10449356") "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber.") AnnotationAssertion(rdfs:label "oocyte localization involved in germarium-derived egg chamber formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15567,27 +20483,32 @@ SubClassOf( ObjectAllValuesFrom( (granulocyte differentiation) +AnnotationAssertion(Annotation( "GOC:ecd") Annotation( "http://life.nthu.edu.tw/~g864204/dict-search1.htm") "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.") AnnotationAssertion(rdfs:label "granulocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of granulocyte differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of granulocyte differentiation.") AnnotationAssertion(rdfs:label "regulation of granulocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of granulocyte differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.") AnnotationAssertion(rdfs:label "negative regulation of granulocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of granulocyte differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.") AnnotationAssertion(rdfs:label "positive regulation of granulocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (epithelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:ecd") Annotation( "PMID:11839751") "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.") AnnotationAssertion(rdfs:label "epithelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15595,6 +20516,7 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of epithelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of epithelial cell differentiation.") AnnotationAssertion(rdfs:label "regulation of epithelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15602,6 +20524,7 @@ SubClassOf( (negative regulation of epithelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of epithelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15609,6 +20532,7 @@ SubClassOf( (positive regulation of epithelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of epithelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15616,21 +20540,25 @@ SubClassOf( (regulation of myeloid dendritic cell activation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency or rate of myeloid dendritic cell activation.") AnnotationAssertion(rdfs:label "regulation of myeloid dendritic cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myeloid dendritic cell activation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.") AnnotationAssertion(rdfs:label "negative regulation of myeloid dendritic cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myeloid dendritic cell activation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.") AnnotationAssertion(rdfs:label "positive regulation of myeloid dendritic cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (midbrain development) +AnnotationAssertion(Annotation( "PMID:4975589") Annotation( "PMID:4992177") "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).") AnnotationAssertion(rdfs:label "midbrain development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15639,6 +20567,7 @@ SubClassOf( ObjectSomeValuesFrom( (hindbrain development) +AnnotationAssertion(Annotation( "PMID:4975589") Annotation( "PMID:4992177") "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).") AnnotationAssertion(rdfs:label "hindbrain development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15647,12 +20576,14 @@ SubClassOf( ObjectSomeValuesFrom( (notochord development) +AnnotationAssertion(Annotation( "GOC:dgh") "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.") AnnotationAssertion(rdfs:label "notochord development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (midbrain-hindbrain boundary development) +AnnotationAssertion(Annotation( "GOC:dgh") "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.") AnnotationAssertion(rdfs:label "midbrain-hindbrain boundary development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15662,116 +20593,173 @@ SubClassOf( ObjectSomeValuesFrom( (transmembrane collagen trimer) +AnnotationAssertion(Annotation( "ISBN:0721639976") "Any collagen trimer that passes through a lipid bilayer membrane.") AnnotationAssertion(rdfs:label "transmembrane collagen trimer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (establishment or maintenance of microtubule cytoskeleton polarity) +AnnotationAssertion(Annotation( "GOC:mah") "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.") AnnotationAssertion(rdfs:label "establishment or maintenance of microtubule cytoskeleton polarity") SubClassOf( ) SubClassOf( ) # Class: (establishment or maintenance of cytoskeleton polarity) +AnnotationAssertion(Annotation( "GOC:mah") "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures.") AnnotationAssertion(rdfs:label "establishment or maintenance of cytoskeleton polarity") SubClassOf( ) SubClassOf( ) # Class: (intraciliary transport particle) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:kmv") Annotation( "PMID:14570576") Annotation( "PMID:22118932") Annotation( "PMID:23945166") "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.") +AnnotationAssertion(rdfs:comment "Note that we deem cilia and microtubule-based flagella to be equivalent.") AnnotationAssertion(rdfs:label "intraciliary transport particle") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (extracellular matrix) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") Annotation( "GOC:rph") Annotation( "NIF_Subcellular:nlx_subcell_20090513") Annotation( "PMID:21123617") Annotation( "PMID:28089324") "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.") +AnnotationAssertion( "NIF_Subcellular:nlx_subcell_20090513") +AnnotationAssertion( "Wikipedia:Extracellular_matrix") AnnotationAssertion(rdfs:label "extracellular matrix") SubClassOf( ) DisjointClasses( ) DisjointClasses( ) +# Class: (pancreas development) + +AnnotationAssertion(Annotation( "GOC:cvs") "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones.") +AnnotationAssertion( "Wikipedia:Pancreas") +AnnotationAssertion(rdfs:label "pancreas development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (exocrine pancreas development) + +AnnotationAssertion(Annotation( "GOC:cvs") "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.") +AnnotationAssertion(rdfs:label "exocrine pancreas development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (endocrine pancreas development) + +AnnotationAssertion(Annotation( "GOC:cvs") "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.") +AnnotationAssertion(rdfs:label "endocrine pancreas development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (nuclear migration along microfilament) +AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.") AnnotationAssertion(rdfs:label "nuclear migration along microfilament") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (actomyosin structure organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.") +AnnotationAssertion(rdfs:comment "Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins.") AnnotationAssertion(rdfs:label "actomyosin structure organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (dense core granule) +AnnotationAssertion(Annotation( "NIF_Subcellular:sao772007592") Annotation( "PMID:14690495") "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.") +AnnotationAssertion( "NIF_Subcellular:sao772007592") AnnotationAssertion(rdfs:label "dense core granule") SubClassOf( ) # Class: (embryonic camera-type eye development) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:mtg_sensu") "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "embryonic camera-type eye development") SubClassOf( ) SubClassOf( ) # Class: (organelle membrane) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:mah") "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.") +AnnotationAssertion( "NIF_Subcellular:sao830981606") AnnotationAssertion(rdfs:label "organelle membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (microtubule polymerization or depolymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.") AnnotationAssertion(rdfs:label "microtubule polymerization or depolymerization") SubClassOf( ) # Class: (regulation of microtubule polymerization or depolymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.") AnnotationAssertion(rdfs:label "regulation of microtubule polymerization or depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of microtubule polymerization or depolymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.") AnnotationAssertion(rdfs:label "negative regulation of microtubule polymerization or depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of microtubule polymerization or depolymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization.") AnnotationAssertion(rdfs:label "positive regulation of microtubule polymerization or depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of microtubule polymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of microtubule polymerization.") AnnotationAssertion(rdfs:label "regulation of microtubule polymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of microtubule depolymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of microtubule depolymerization.") AnnotationAssertion(rdfs:label "regulation of microtubule depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of microtubule polymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.") AnnotationAssertion(rdfs:label "negative regulation of microtubule polymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of microtubule polymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of microtubule polymerization.") AnnotationAssertion(rdfs:label "positive regulation of microtubule polymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of microtubule depolymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.") AnnotationAssertion(rdfs:label "positive regulation of microtubule depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cytoplasmic microtubule organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.") AnnotationAssertion(rdfs:label "cytoplasmic microtubule organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (developmental induction) +AnnotationAssertion(Annotation( "GOC:cjm") Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "PMID:24503535") "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder).") AnnotationAssertion(rdfs:label "developmental induction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15781,23 +20769,28 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (pseudopodium) +AnnotationAssertion(Annotation( "ISBN:0198506732") "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.") +AnnotationAssertion( "Wikipedia:Pseudopod") AnnotationAssertion(rdfs:label "pseudopodium") SubClassOf( ) # Class: (neuron projection development) +AnnotationAssertion(Annotation( "GOC:mah") "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).") AnnotationAssertion(rdfs:label "neuron projection development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cell leading edge) +AnnotationAssertion(Annotation( "GOC:pg") "The area of a motile cell closest to the direction of movement.") AnnotationAssertion(rdfs:label "cell leading edge") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cell projection membrane) +AnnotationAssertion(Annotation( "GOC:krc") Annotation( "GOC:mah") "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.") AnnotationAssertion(rdfs:label "cell projection membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -15805,6 +20798,7 @@ SubClassOf( ObjectSomeValuesFrom( (leading edge membrane) +AnnotationAssertion(Annotation( "GOC:mah") "The portion of the plasma membrane surrounding the leading edge of a motile cell.") AnnotationAssertion(rdfs:label "leading edge membrane") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -15812,38 +20806,46 @@ SubClassOf( ObjectSomeValuesFrom( (pseudopodium organization) +AnnotationAssertion(Annotation( "GOC:pg") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.") AnnotationAssertion(rdfs:label "pseudopodium organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (pseudopodium assembly) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:pg") Annotation( "GOC:tb") "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane.") AnnotationAssertion(rdfs:label "pseudopodium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (pseudopodium retraction) +AnnotationAssertion(Annotation( "GOC:pg") "The myosin-based contraction and retraction of a pseudopodium.") AnnotationAssertion(rdfs:label "pseudopodium retraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of pseudopodium assembly) +AnnotationAssertion(Annotation( "GOC:pg") "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia.") AnnotationAssertion(rdfs:label "regulation of pseudopodium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of pseudopodium assembly) +AnnotationAssertion(Annotation( "GOC:pg") "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia.") AnnotationAssertion(rdfs:label "negative regulation of pseudopodium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of pseudopodium assembly) +AnnotationAssertion(Annotation( "GOC:pg") "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.") AnnotationAssertion(rdfs:label "positive regulation of pseudopodium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cellular metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "regulation of cellular metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15851,6 +20853,8 @@ SubClassOf( (negative regulation of cellular metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "negative regulation of cellular metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15859,6 +20863,8 @@ SubClassOf( (positive regulation of cellular metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "positive regulation of cellular metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15867,6 +20873,8 @@ SubClassOf( (regulation of cellular biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "regulation of cellular biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15874,6 +20882,8 @@ SubClassOf( (negative regulation of cellular biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "negative regulation of cellular biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15882,25 +20892,59 @@ SubClassOf( (positive regulation of cellular biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "positive regulation of cellular biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ) +# Class: (regulation of cellular catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") +AnnotationAssertion(rdfs:label "regulation of cellular catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (negative regulation of cellular catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") +AnnotationAssertion(rdfs:label "negative regulation of cellular catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of cellular catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") +AnnotationAssertion(rdfs:label "positive regulation of cellular catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (negative regulation of protein-containing complex assembly) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.") AnnotationAssertion(rdfs:label "negative regulation of protein-containing complex assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein-containing complex assembly) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of protein complex assembly.") AnnotationAssertion(rdfs:label "positive regulation of protein-containing complex assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of vesicle fusion) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of vesicle fusion.") AnnotationAssertion(rdfs:label "regulation of vesicle fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15908,6 +20952,7 @@ SubClassOf( (negative regulation of vesicle fusion) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion.") AnnotationAssertion(rdfs:label "negative regulation of vesicle fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15916,6 +20961,7 @@ SubClassOf( (positive regulation of vesicle fusion) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of vesicle fusion.") AnnotationAssertion(rdfs:label "positive regulation of vesicle fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15924,27 +20970,32 @@ SubClassOf( (regulation of cell projection organization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.") AnnotationAssertion(rdfs:label "regulation of cell projection organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cell projection organization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.") AnnotationAssertion(rdfs:label "negative regulation of cell projection organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cell projection organization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.") AnnotationAssertion(rdfs:label "positive regulation of cell projection organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of defense response) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of a defense response.") AnnotationAssertion(rdfs:label "regulation of defense response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of defense response) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.") AnnotationAssertion(rdfs:label "negative regulation of defense response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15952,6 +21003,7 @@ SubClassOf( (positive regulation of defense response) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of a defense response.") AnnotationAssertion(rdfs:label "positive regulation of defense response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15959,6 +21011,8 @@ SubClassOf( (cytoplasmic vesicle) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mah") Annotation( "GOC:vesicles") "A vesicle found in the cytoplasm of a cell.") +AnnotationAssertion( "NIF_Subcellular:sao180601769") AnnotationAssertion(rdfs:label "cytoplasmic vesicle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -15966,47 +21020,59 @@ SubClassOf( ObjectSomeValuesFrom( (protein-containing complex localization) +AnnotationAssertion(Annotation( "GOC:mah") "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.") AnnotationAssertion(rdfs:label "protein-containing complex localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (motile cilium) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dgh") Annotation( "GOC:kmv") Annotation( "PMID:17009929") Annotation( "PMID:20144998") Annotation( "PMID:22118931") "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.") AnnotationAssertion(rdfs:label "motile cilium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (neuromuscular junction) +AnnotationAssertion(Annotation( "GOC:nln") "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.") +AnnotationAssertion( "NIF_Subcellular:sao1124888485") +AnnotationAssertion( "Wikipedia:Neuromuscular_junction") +AnnotationAssertion(rdfs:comment "In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.") AnnotationAssertion(rdfs:label "neuromuscular junction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of nervous system process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.") AnnotationAssertion(rdfs:label "regulation of nervous system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of nervous system process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:tb") "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.") AnnotationAssertion(rdfs:label "negative regulation of nervous system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of nervous system process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of a neurophysiological process.") AnnotationAssertion(rdfs:label "positive regulation of nervous system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (nuclear membrane) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:pz") "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.") +AnnotationAssertion( "NIF_Subcellular:sao1687101204") AnnotationAssertion(rdfs:label "nuclear membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (organelle envelope) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:pz") "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.") AnnotationAssertion(rdfs:label "organelle envelope") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -16014,6 +21080,7 @@ SubClassOf( ObjectSomeValuesFrom( (organelle outer membrane) +AnnotationAssertion(Annotation( "GOC:mah") "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope.") AnnotationAssertion(rdfs:label "organelle outer membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16022,49 +21089,121 @@ SubClassOf( ObjectSomeValuesFrom( (membrane-enclosed lumen) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.") AnnotationAssertion(rdfs:label "membrane-enclosed lumen") SubClassOf( ) DisjointClasses( ) # Class: (nuclear lumen) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:pz") "The volume enclosed by the nuclear inner membrane.") AnnotationAssertion(rdfs:label "nuclear lumen") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vesicle) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:pz") Annotation( "GOC:vesicles") "Any small, fluid-filled, spherical organelle enclosed by membrane.") +AnnotationAssertion( "NIF_Subcellular:sao221389602") +AnnotationAssertion( "Wikipedia:Vesicle_(biology)") AnnotationAssertion(rdfs:label "vesicle") SubClassOf( ) +# Class: (locomotion involved in locomotory behavior) + +AnnotationAssertion(Annotation( "GOC:mah") "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.") +AnnotationAssertion(rdfs:label "locomotion involved in locomotory behavior") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (positive regulation of insulin secretion) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.") +AnnotationAssertion(rdfs:label "positive regulation of insulin secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (negative regulation of translational initiation in response to stress) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.") AnnotationAssertion(rdfs:label "negative regulation of translational initiation in response to stress") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (positive regulation of translational initiation in response to stress) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.") AnnotationAssertion(rdfs:label "positive regulation of translational initiation in response to stress") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (bleb) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:12083798") Annotation( "PMID:16624291") Annotation( "Wikipedia:Bleb_(cell_biology)") "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.") +AnnotationAssertion( "Wikipedia:Bleb_(cell_biology)") AnnotationAssertion(rdfs:label "bleb") SubClassOf( ) # Class: (bleb assembly) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:12083798") Annotation( "PMID:16624291") Annotation( "Wikipedia:Bleb_(cell_biology)") "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.") AnnotationAssertion(rdfs:label "bleb assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of nuclease activity) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.") +AnnotationAssertion(rdfs:label "regulation of nuclease activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (regulation of deoxyribonuclease activity) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.") +AnnotationAssertion(rdfs:label "regulation of deoxyribonuclease activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (negative regulation of nuclease activity) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids.") +AnnotationAssertion(rdfs:label "negative regulation of nuclease activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (positive regulation of nuclease activity) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.") +AnnotationAssertion(rdfs:label "positive regulation of nuclease activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (negative regulation of deoxyribonuclease activity) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.") +AnnotationAssertion(rdfs:label "negative regulation of deoxyribonuclease activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (positive regulation of deoxyribonuclease activity) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.") +AnnotationAssertion(rdfs:label "positive regulation of deoxyribonuclease activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (regulation of response to external stimulus) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of a response to an external stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "regulation of response to external stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of response to external stimulus) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "negative regulation of response to external stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16072,6 +21211,8 @@ SubClassOf( (positive regulation of response to external stimulus) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates, maintains or increases the rate of a response to an external stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "positive regulation of response to external stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16079,24 +21220,28 @@ SubClassOf( (dense core granule membrane) +AnnotationAssertion(Annotation( "GOC:mah") "The lipid bilayer surrounding a dense core granule.") AnnotationAssertion(rdfs:label "dense core granule membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of actin filament bundle assembly) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.") AnnotationAssertion(rdfs:label "regulation of actin filament bundle assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of actin filament bundle assembly) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles.") AnnotationAssertion(rdfs:label "negative regulation of actin filament bundle assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of actin filament bundle assembly) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.") AnnotationAssertion(rdfs:label "positive regulation of actin filament bundle assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16104,46 +21249,55 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of nucleobase-containing compound transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "regulation of nucleobase-containing compound transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of nucleobase-containing compound transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "negative regulation of nucleobase-containing compound transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of nucleobase-containing compound transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "positive regulation of nucleobase-containing compound transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (secretory granule localization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.") AnnotationAssertion(rdfs:label "secretory granule localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (dense core granule localization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell.") AnnotationAssertion(rdfs:label "dense core granule localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of protein polymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the process of creating protein polymers.") AnnotationAssertion(rdfs:label "regulation of protein polymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein polymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.") AnnotationAssertion(rdfs:label "negative regulation of protein polymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein polymerization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.") AnnotationAssertion(rdfs:label "positive regulation of protein polymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of chondrocyte differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of chondrocyte differentiation.") AnnotationAssertion(rdfs:label "regulation of chondrocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16151,6 +21305,7 @@ SubClassOf( (negative regulation of chondrocyte differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.") AnnotationAssertion(rdfs:label "negative regulation of chondrocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16159,19 +21314,28 @@ SubClassOf( (positive regulation of chondrocyte differentiation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.") AnnotationAssertion(rdfs:label "positive regulation of chondrocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ) +# Class: (intracellular oxygen homeostasis) + +AnnotationAssertion(Annotation( "GOC:rph") "A homeostatic process involved in the maintenance of a steady state level of oxygen within a cell.") +AnnotationAssertion(rdfs:label "intracellular oxygen homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (intracellular lipid transport) +AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of lipids within cells.") AnnotationAssertion(rdfs:label "intracellular lipid transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (regulation of lipid transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "regulation of lipid transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16179,6 +21343,7 @@ SubClassOf( ObjectSomeValuesFrom( (negative regulation of lipid transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "negative regulation of lipid transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16187,6 +21352,7 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of lipid transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "positive regulation of lipid transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16195,41 +21361,89 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of intracellular lipid transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells.") AnnotationAssertion(rdfs:label "regulation of intracellular lipid transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of intracellular lipid transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells.") AnnotationAssertion(rdfs:label "negative regulation of intracellular lipid transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of intracellular lipid transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells.") AnnotationAssertion(rdfs:label "positive regulation of intracellular lipid transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of intracellular transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.") AnnotationAssertion(rdfs:label "regulation of intracellular transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of intracellular transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.") AnnotationAssertion(rdfs:label "negative regulation of intracellular transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of intracellular transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.") AnnotationAssertion(rdfs:label "positive regulation of intracellular transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of transporter activity) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the activity of a transporter.") +AnnotationAssertion(rdfs:label "regulation of transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of transporter activity) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops or reduces the activity of a transporter.") +AnnotationAssertion(rdfs:label "negative regulation of transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (positive regulation of transporter activity) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the activity of a transporter.") +AnnotationAssertion(rdfs:label "positive regulation of transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (regulation of monoatomic ion transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:tb") "Any process that modulates the activity of an ion transporter.") +AnnotationAssertion(rdfs:label "regulation of monoatomic ion transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of ion transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:tb") "Any process that stops or reduces the activity of an ion transporter.") +AnnotationAssertion(rdfs:label "negative regulation of ion transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (positive regulation of ion transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:tb") "Any process that activates or increases the activity of an ion transporter.") +AnnotationAssertion(rdfs:label "positive regulation of ion transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (lysosome localization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which a lysosome is transported to, and/or maintained in, a specific location.") AnnotationAssertion(rdfs:label "lysosome localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (actin filament bundle) +AnnotationAssertion(Annotation( "GOC:mah") "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.") AnnotationAssertion(rdfs:label "actin filament bundle") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -16238,6 +21452,8 @@ SubClassOf( ObjectSomeValuesFrom( (multicellular organismal process) +AnnotationAssertion(Annotation( "GOC:curators") Annotation( "GOC:dph") Annotation( "GOC:isa_complete") Annotation( "GOC:tb") "Any biological process, occurring at the level of a multicellular organism, pertinent to its function.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "multicellular organismal process") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -16255,11 +21471,13 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (developmental process) +AnnotationAssertion(Annotation( "GOC:isa_complete") "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.") AnnotationAssertion(rdfs:label "developmental process") SubClassOf( ) # Class: (microvillus organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.") AnnotationAssertion(rdfs:label "microvillus organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -16268,16 +21486,19 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (regulation of microvillus organization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus.") AnnotationAssertion(rdfs:label "regulation of microvillus organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of microvillus assembly) +AnnotationAssertion(Annotation( "GOC:mah") "A process that modulates the formation of a microvillus.") AnnotationAssertion(rdfs:label "regulation of microvillus assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (neuron projection membrane) +AnnotationAssertion(Annotation( "GOC:mah") "The portion of the plasma membrane surrounding a neuron projection.") AnnotationAssertion(rdfs:label "neuron projection membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16286,6 +21507,7 @@ SubClassOf( ObjectSomeValuesFrom( (protein transport within lipid bilayer) +AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of a protein from one location to another within a lipid bilayer.") AnnotationAssertion(rdfs:label "protein transport within lipid bilayer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16293,45 +21515,83 @@ SubClassOf( (RNA biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:txnOH") "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.") +AnnotationAssertion(rdfs:comment "Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study.") AnnotationAssertion(rdfs:label "RNA biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (bile acid secretion) + +AnnotationAssertion(Annotation( "GOC:ecd") "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.") +AnnotationAssertion(rdfs:label "bile acid secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (monocarboxylic acid metabolic process) + +AnnotationAssertion(Annotation( "GOC:vk") "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).") +AnnotationAssertion(rdfs:label "monocarboxylic acid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (ribosome disassembly) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:vk") "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.") AnnotationAssertion(rdfs:label "ribosome disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (plasma membrane bounded cell projection cytoplasm) +AnnotationAssertion(Annotation( "GOC:krc") Annotation( "GOC:mah") "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.") AnnotationAssertion(rdfs:label "plasma membrane bounded cell projection cytoplasm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (response to insulin) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.") +AnnotationAssertion(rdfs:label "response to insulin") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (cellular response to insulin stimulus) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.") +AnnotationAssertion(rdfs:label "cellular response to insulin stimulus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (regulation of karyogamy) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion.") AnnotationAssertion(rdfs:label "regulation of karyogamy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of establishment or maintenance of cell polarity) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.") AnnotationAssertion(rdfs:label "regulation of establishment or maintenance of cell polarity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of localization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.") AnnotationAssertion(rdfs:label "regulation of localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of protein localization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.") AnnotationAssertion(rdfs:label "regulation of protein localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of polysaccharide metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides.") AnnotationAssertion(rdfs:label "regulation of polysaccharide metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16339,6 +21599,7 @@ SubClassOf( (regulation of polysaccharide biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.") AnnotationAssertion(rdfs:label "regulation of polysaccharide biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16347,29 +21608,65 @@ SubClassOf( (regulation of microtubule-based process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.") AnnotationAssertion(rdfs:label "regulation of microtubule-based process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of organic acid transport) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") +AnnotationAssertion(rdfs:label "regulation of organic acid transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (negative regulation of organic acid transport) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") +AnnotationAssertion(rdfs:label "negative regulation of organic acid transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of organic acid transport) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") +AnnotationAssertion(rdfs:label "positive regulation of organic acid transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (secretion by cell) +AnnotationAssertion(Annotation( "GOC:mah") "The controlled release of a substance by a cell.") +AnnotationAssertion( "Wikipedia:Secretion") AnnotationAssertion(rdfs:label "secretion by cell") SubClassOf( ) SubClassOf( ) +# Class: (secretion by tissue) + +AnnotationAssertion(Annotation( "GOC:mah") "The controlled release of a substance by a tissue.") +AnnotationAssertion(rdfs:label "secretion by tissue") +SubClassOf( ) +SubClassOf( ) + # Class: (mononuclear cell proliferation) +AnnotationAssertion(Annotation( "GOC:add") "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.") AnnotationAssertion(rdfs:label "mononuclear cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of mononuclear cell proliferation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation.") AnnotationAssertion(rdfs:label "regulation of mononuclear cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of mononuclear cell proliferation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of mononuclear cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16377,6 +21674,7 @@ SubClassOf( (positive regulation of mononuclear cell proliferation) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of mononuclear cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16384,64 +21682,77 @@ SubClassOf( (regulation of actin cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.") AnnotationAssertion(rdfs:label "regulation of actin cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (collagen metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).") AnnotationAssertion(rdfs:label "collagen metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (collagen biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).") AnnotationAssertion(rdfs:label "collagen biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of collagen biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.") AnnotationAssertion(rdfs:label "regulation of collagen biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of collagen biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.") AnnotationAssertion(rdfs:label "negative regulation of collagen biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of collagen biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.") AnnotationAssertion(rdfs:label "positive regulation of collagen biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of actin filament-based process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.") AnnotationAssertion(rdfs:label "regulation of actin filament-based process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein-containing complex disassembly) +AnnotationAssertion(Annotation( "GOC:mah") "The disaggregation of a protein-containing macromolecular complex into its constituent components.") AnnotationAssertion(rdfs:label "protein-containing complex disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein-DNA complex disassembly) +AnnotationAssertion(Annotation( "GOC:mah") "The disaggregation of a protein-DNA complex into its constituent components.") AnnotationAssertion(rdfs:label "protein-DNA complex disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein-RNA complex disassembly) +AnnotationAssertion(Annotation( "GOC:mah") "The disaggregation of a protein-RNA complex into its constituent components.") AnnotationAssertion(rdfs:label "protein-RNA complex disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cellular anatomical entity morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:tb") "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system.") AnnotationAssertion(rdfs:label "cellular anatomical entity morphogenesis") SubClassOf( ) # Class: (protein-containing complex) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:mah") "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.") +AnnotationAssertion(rdfs:comment "A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.") AnnotationAssertion(rdfs:label "protein-containing complex") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -16449,6 +21760,8 @@ DisjointClasses( (protein-DNA complex) +AnnotationAssertion(Annotation( "GOC:mah") "A macromolecular complex containing both protein and DNA molecules.") +AnnotationAssertion(rdfs:comment "Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here.") AnnotationAssertion(rdfs:label "protein-DNA complex") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -16456,113 +21769,152 @@ SubClassOf( ObjectSomeValuesFrom( (Fc receptor complex) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin.") AnnotationAssertion(rdfs:label "Fc receptor complex") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (Fc-gamma receptor III complex) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:11244038") Annotation( "PMID:12413532") "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG.") AnnotationAssertion(rdfs:label "Fc-gamma receptor III complex") SubClassOf( ) # Class: (muscle cell proliferation) +AnnotationAssertion(Annotation( "CL:0000187") Annotation( "GOC:mah") "The expansion of a muscle cell population by cell division.") AnnotationAssertion(rdfs:label "muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myeloid cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000763") Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:11292031") Annotation( "PMID:15330259") Annotation( "PMID:17133093") "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.") AnnotationAssertion(rdfs:label "myeloid cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of myeloid cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process.") AnnotationAssertion(rdfs:label "regulation of myeloid cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myeloid cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of myeloid cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myeloid cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of myeloid cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (macromolecule localization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which a macromolecule is transported to, or maintained in, a specific location.") AnnotationAssertion(rdfs:label "macromolecule localization") SubClassOf( ) # Class: (polysaccharide localization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which a polysaccharide is transported to, or maintained in, a specific location.") AnnotationAssertion(rdfs:label "polysaccharide localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of organelle organization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.") AnnotationAssertion(rdfs:label "regulation of organelle organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of chromosome organization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.") AnnotationAssertion(rdfs:label "regulation of chromosome organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of sister chromatid segregation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of sister chromatid segregation.") AnnotationAssertion(rdfs:label "regulation of sister chromatid segregation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of sister chromatid segregation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.") AnnotationAssertion(rdfs:label "negative regulation of sister chromatid segregation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of mitotic sister chromatid segregation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.") AnnotationAssertion(rdfs:label "regulation of mitotic sister chromatid segregation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of mitotic sister chromatid segregation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.") AnnotationAssertion(rdfs:label "negative regulation of mitotic sister chromatid segregation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular pigmentation) +AnnotationAssertion(Annotation( "GOC:mtg_MIT_16mar07") "The deposition or aggregation of coloring matter in a cell.") AnnotationAssertion(rdfs:label "cellular pigmentation") SubClassOf( ) SubClassOf( ) # Class: (regulation of intracellular protein transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.") AnnotationAssertion(rdfs:label "regulation of intracellular protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of amine metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines.") AnnotationAssertion(rdfs:label "regulation of amine metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of amine metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines.") AnnotationAssertion(rdfs:label "negative regulation of amine metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of amine metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines.") AnnotationAssertion(rdfs:label "positive regulation of amine metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of amine catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.") +AnnotationAssertion(rdfs:label "regulation of amine catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of amine catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.") +AnnotationAssertion(rdfs:label "negative regulation of amine catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of amine catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines.") +AnnotationAssertion(rdfs:label "positive regulation of amine catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (cell proliferation in midbrain) +AnnotationAssertion(Annotation( "GOC:dgf") Annotation( "GO_REF:0000021") "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.") AnnotationAssertion(rdfs:label "cell proliferation in midbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16570,29 +21922,40 @@ SubClassOf( ObjectSomeValuesFrom( (secretory granule organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.") AnnotationAssertion(rdfs:label "secretory granule organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (protein localization to organelle) +AnnotationAssertion(Annotation( "GOC:mah") "A process in which a protein is transported to, or maintained in, a location within an organelle.") AnnotationAssertion(rdfs:label "protein localization to organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein localization to secretory granule) +AnnotationAssertion(Annotation( "GOC:mah") "A process in which a protein is transported to, or maintained in, a location within a secretory granule.") AnnotationAssertion(rdfs:label "protein localization to secretory granule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (T cell secretory granule organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.") AnnotationAssertion(rdfs:label "T cell secretory granule organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (carbohydrate homeostasis) + +AnnotationAssertion(Annotation( "GOC:mah") "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell.") +AnnotationAssertion(rdfs:label "carbohydrate homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (negative regulation of catecholamine secretion) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine.") AnnotationAssertion(rdfs:label "negative regulation of catecholamine secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16601,6 +21964,7 @@ SubClassOf( (positive regulation of catecholamine secretion) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.") AnnotationAssertion(rdfs:label "positive regulation of catecholamine secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16609,189 +21973,255 @@ SubClassOf( (ribosome localization) +AnnotationAssertion(Annotation( "GOC:mah") "A process in which a ribosome is transported to, and/or maintained in, a specific location.") AnnotationAssertion(rdfs:label "ribosome localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (response to glucagon) +AnnotationAssertion(Annotation( "GOC:sl") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.") AnnotationAssertion(rdfs:label "response to glucagon") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (response to lipid) +AnnotationAssertion(Annotation( "GOC:sl") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.") AnnotationAssertion(rdfs:label "response to lipid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to Golgi apparatus) +AnnotationAssertion(Annotation( "GOC:mah") "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.") AnnotationAssertion(rdfs:label "protein localization to Golgi apparatus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (erythrocyte homeostasis) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:10694114") Annotation( "PMID:14754397") "Any process of regulating the production and elimination of erythrocytes within an organism.") AnnotationAssertion(rdfs:label "erythrocyte homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of tissue remodeling) +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of tissue remodeling.") AnnotationAssertion(rdfs:label "regulation of tissue remodeling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of tissue remodeling) +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling.") AnnotationAssertion(rdfs:label "negative regulation of tissue remodeling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of tissue remodeling) +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of tissue remodeling.") AnnotationAssertion(rdfs:label "positive regulation of tissue remodeling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (carbohydrate transmembrane transport) +AnnotationAssertion(Annotation( "GOC:mah") "The process in which a carbohydrate is transported across a membrane.") +AnnotationAssertion(rdfs:comment "Note that this term is not intended for use in annotating lateral movement within membranes.") AnnotationAssertion(rdfs:label "carbohydrate transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (monoatomic ion transmembrane transport) +AnnotationAssertion(Annotation( "GOC:mah") "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.") +AnnotationAssertion(rdfs:comment "Note that this term is not intended for use in annotating lateral movement within membranes.") AnnotationAssertion(rdfs:label "monoatomic ion transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (negative regulation of syncytium formation by plasma membrane fusion) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.") AnnotationAssertion(rdfs:label "negative regulation of syncytium formation by plasma membrane fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of amide metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides.") AnnotationAssertion(rdfs:label "regulation of amide metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of amide metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides.") AnnotationAssertion(rdfs:label "negative regulation of amide metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of amide metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides.") AnnotationAssertion(rdfs:label "positive regulation of amide metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of amide catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.") +AnnotationAssertion(rdfs:label "regulation of amide catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of amide catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.") +AnnotationAssertion(rdfs:label "negative regulation of amide catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of amide catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides.") +AnnotationAssertion(rdfs:label "positive regulation of amide catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (cell junction assembly) +AnnotationAssertion(Annotation( "GOC:mah") "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.") AnnotationAssertion(rdfs:label "cell junction assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell junction organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.") AnnotationAssertion(rdfs:label "cell junction organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (glial cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000125") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:sart") "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.") AnnotationAssertion(rdfs:label "glial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of glial cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process.") AnnotationAssertion(rdfs:label "regulation of glial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of glial cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of glial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of glial cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of glial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (smooth muscle cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:BHF") Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:rl") "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels.") AnnotationAssertion(rdfs:label "smooth muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of smooth muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:rl") "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process.") AnnotationAssertion(rdfs:label "regulation of smooth muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of smooth muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:rl") "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of smooth muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of smooth muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:rl") "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of smooth muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (glycoprotein transport) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") Annotation( "GOC:rl") "The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "glycoprotein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (vacuolar transmembrane transport) +AnnotationAssertion(Annotation( "GOC:mah") "The process in which a solute is transported from one side of the vacuolar membrane to the other.") +AnnotationAssertion(rdfs:comment "Note that this term is not intended for use in annotating lateral movement within membranes.") AnnotationAssertion(rdfs:label "vacuolar transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (protein localization to chromosome) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.") AnnotationAssertion(rdfs:label "protein localization to chromosome") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to nucleus) +AnnotationAssertion(Annotation( "GOC:ecd") "A process in which a protein transports or maintains the localization of another protein to the nucleus.") AnnotationAssertion(rdfs:label "protein localization to nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (nucleobase-containing compound biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.") AnnotationAssertion(rdfs:label "nucleobase-containing compound biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (nucleobase-containing compound catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.") +AnnotationAssertion(rdfs:label "nucleobase-containing compound catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (regulation of transmembrane transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.") AnnotationAssertion(rdfs:label "regulation of transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of transmembrane transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.") AnnotationAssertion(rdfs:label "negative regulation of transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of transmembrane transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.") AnnotationAssertion(rdfs:label "positive regulation of transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of monoatomic ion transmembrane transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.") AnnotationAssertion(rdfs:label "regulation of monoatomic ion transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of monoatomic ion transmembrane transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.") AnnotationAssertion(rdfs:label "negative regulation of monoatomic ion transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of monoatomic ion transmembrane transport) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.") AnnotationAssertion(rdfs:label "positive regulation of monoatomic ion transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (basement membrane disassembly) +AnnotationAssertion(Annotation( "GOC:sart") Annotation( "PMID:17301221") "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.") +AnnotationAssertion(rdfs:comment "Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer.") AnnotationAssertion(rdfs:label "basement membrane disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (embryonic heart tube development) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.") AnnotationAssertion(rdfs:label "embryonic heart tube development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16801,6 +22231,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiocyte differentiation) +AnnotationAssertion(Annotation( "GOC:bf") "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.") AnnotationAssertion(rdfs:label "cardiocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16808,6 +22239,8 @@ SubClassOf( ObjectSomeValuesFrom( (axoneme assembly) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:cilia") Annotation( "GOC:jl") Annotation( "ISBN:0815316194") "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.") +AnnotationAssertion(rdfs:comment "Note that cilia and eukaryotic flagella are deemed to be equivalent.") AnnotationAssertion(rdfs:label "axoneme assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16815,6 +22248,7 @@ SubClassOf( ObjectSomeValuesFrom( (appendage morphogenesis) +AnnotationAssertion(Annotation( "ISBN:0582227089") "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.") AnnotationAssertion(rdfs:label "appendage morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16823,6 +22257,7 @@ SubClassOf( ObjectSomeValuesFrom( (genitalia morphogenesis) +AnnotationAssertion(Annotation( "GOC:bf") "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.") AnnotationAssertion(rdfs:label "genitalia morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16831,6 +22266,7 @@ SubClassOf( ObjectSomeValuesFrom( (tube formation) +AnnotationAssertion(Annotation( "GOC:bf") "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.") AnnotationAssertion(rdfs:label "tube formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16839,6 +22275,7 @@ SubClassOf( ObjectSomeValuesFrom( (syncytial nuclear migration) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "ISBN:0879694238") Annotation( "PMID:8314839") "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisions and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex.") AnnotationAssertion(rdfs:label "syncytial nuclear migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16846,6 +22283,7 @@ SubClassOf( ObjectSomeValuesFrom( (ectopic germ cell programmed cell death) +AnnotationAssertion(Annotation( "PMID:12814944") "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.") AnnotationAssertion(rdfs:label "ectopic germ cell programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16853,6 +22291,7 @@ SubClassOf( (tube morphogenesis) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "PMID:14624839") "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.") AnnotationAssertion(rdfs:label "tube morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16861,18 +22300,21 @@ SubClassOf( ObjectSomeValuesFrom( (internal genitalia morphogenesis) +AnnotationAssertion(Annotation( "PMID:24793987") Annotation( "PMID:25247640") "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.") AnnotationAssertion(rdfs:label "internal genitalia morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (external genitalia morphogenesis) +AnnotationAssertion(Annotation( "PMID:24793987") Annotation( "PMID:25247640") "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals.") AnnotationAssertion(rdfs:label "external genitalia morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (gonad morphogenesis) +AnnotationAssertion(Annotation( "ISBN:0198612001") "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.") AnnotationAssertion(rdfs:label "gonad morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16881,6 +22323,7 @@ SubClassOf( ObjectSomeValuesFrom( (multicellular organism growth) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:curators") Annotation( "GOC:dph") Annotation( "GOC:tb") "The increase in size or mass of an entire multicellular organism, as opposed to cell growth.") AnnotationAssertion(rdfs:label "multicellular organism growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16888,35 +22331,42 @@ SubClassOf( (organ growth) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "ISBN:0471245208") Annotation( "ISBN:0721662544") "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.") AnnotationAssertion(rdfs:label "organ growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (endocrine system development) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "Wikipedia:Development_of_the_endocrine_system") "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.") AnnotationAssertion(rdfs:label "endocrine system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (exocrine system development) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "Wikipedia:Exocrine_gland") "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system.") AnnotationAssertion(rdfs:label "exocrine system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (segmentation) +AnnotationAssertion(Annotation( "PMID:10611687") Annotation( "PMID:9706689") "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.") +AnnotationAssertion( "Wikipedia:Segmentation_(biology)") AnnotationAssertion(rdfs:label "segmentation") SubClassOf( ) # Class: (trunk segmentation) +AnnotationAssertion(Annotation( "PMID:1360402") "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8.") AnnotationAssertion(rdfs:label "trunk segmentation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (tube development) +AnnotationAssertion(Annotation( "PMID:12526790") "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.") AnnotationAssertion(rdfs:label "tube development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16924,27 +22374,32 @@ SubClassOf( ObjectSomeValuesFrom( (protein localization to microtubule) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:lb") "A process in which a protein is transported to, or maintained at, a microtubule.") AnnotationAssertion(rdfs:label "protein localization to microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein localization to synapse) +AnnotationAssertion(Annotation( "GOC:bf") "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.") AnnotationAssertion(rdfs:label "protein localization to synapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell migration involved in vasculogenesis) +AnnotationAssertion(Annotation( "GOC:dgh") "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.") AnnotationAssertion(rdfs:label "cell migration involved in vasculogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (intracellular signal transduction) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:jl") Annotation( "GOC:signaling") Annotation( "ISBN:3527303782") "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.") AnnotationAssertion(rdfs:label "intracellular signal transduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (azurophil granule membrane) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "PMID:17152095") "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.") AnnotationAssertion(rdfs:label "azurophil granule membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16953,19 +22408,48 @@ SubClassOf( ObjectSomeValuesFrom( (establishment of protein localization to extracellular region) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:bf") "The directed movement of a protein to a specific location within the extracellular region.") AnnotationAssertion(rdfs:label "establishment of protein localization to extracellular region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (intrahepatic bile duct development) + +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "PMID:20614624") "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).") +AnnotationAssertion(rdfs:label "intrahepatic bile duct development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (cystic duct development) + +AnnotationAssertion(Annotation( "PMID:20614624") "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct.") +AnnotationAssertion(rdfs:label "cystic duct development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (enteric smooth muscle cell differentiation) + +AnnotationAssertion(Annotation( "CL:0002504") Annotation( "GOC:BHF") "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine.") +AnnotationAssertion(rdfs:label "enteric smooth muscle cell differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (hematopoietic stem cell migration) +AnnotationAssertion(Annotation( "CL:0000037") Annotation( "GOC:BHF") Annotation( "PMID:20234092") "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.") AnnotationAssertion(rdfs:label "hematopoietic stem cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (monocyte homeostasis) +AnnotationAssertion(Annotation( "CL:0000576") Annotation( "GOC:BHF") Annotation( "PMID:18832716") "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.") AnnotationAssertion(rdfs:label "monocyte homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -16973,34 +22457,62 @@ SubClassOf( (intraciliary transport involved in cilium assembly) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:cilia") "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.") AnnotationAssertion(rdfs:label "intraciliary transport involved in cilium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell proliferation involved in compound eye morphogenesis) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:sart") "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis.") AnnotationAssertion(rdfs:label "cell proliferation involved in compound eye morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (endothelial cell chemotaxis) +AnnotationAssertion(Annotation( "CL:0000115") Annotation( "GOC:BHF") "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).") AnnotationAssertion(rdfs:label "endothelial cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (insulin secretion involved in cellular response to glucose stimulus) + +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:yaf") Annotation( "PMID:8492079") "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus.") +AnnotationAssertion(rdfs:label "insulin secretion involved in cellular response to glucose stimulus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of insulin secretion involved in cellular response to glucose stimulus) + +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:yaf") "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.") +AnnotationAssertion(rdfs:label "positive regulation of insulin secretion involved in cellular response to glucose stimulus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (angioblast cell differentiation) +AnnotationAssertion(Annotation( "CL:0000566") Annotation( "GOC:yaf") "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells).") AnnotationAssertion(rdfs:label "angioblast cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (egg coat) +AnnotationAssertion(Annotation( "PMID:16944418") Annotation( "PMID:17163408") "A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.") AnnotationAssertion(rdfs:label "egg coat") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectAllValuesFrom( )) +# Class: (cloaca development) + +AnnotationAssertion(Annotation( "GOC:dgh") Annotation( "ISBN:0582227089") "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates.") +AnnotationAssertion(rdfs:label "cloaca development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (megakaryocyte development) +AnnotationAssertion(Annotation( "CL:0000556") Annotation( "GOC:BHF") Annotation( "GOC:vk") "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.") AnnotationAssertion(rdfs:label "megakaryocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17008,17 +22520,21 @@ SubClassOf( ObjectSomeValuesFrom( (ciliary transition zone) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:kmv") Annotation( "PMID:21422230") "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.") +AnnotationAssertion(rdfs:comment "Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone.") AnnotationAssertion(rdfs:label "ciliary transition zone") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (enteroendocrine cell differentiation) +AnnotationAssertion(Annotation( "CL:0000164") Annotation( "GOC:bf") "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.") AnnotationAssertion(rdfs:label "enteroendocrine cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (vascular associated smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:sl") Annotation( "PMID:16151017") Annotation( "PMID:18267954") "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.") AnnotationAssertion(rdfs:label "vascular associated smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17026,18 +22542,21 @@ SubClassOf( ObjectSomeValuesFrom( (aortic smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:sl") "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta.") AnnotationAssertion(rdfs:label "aortic smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (aorta development) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dgh") Annotation( "MA:0000062") Annotation( "UBERON:0000947") Annotation( "Wikipedia:Aorta") "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.") AnnotationAssertion(rdfs:label "aorta development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (ascending aorta development) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dgh") Annotation( "MA:0002570") Annotation( "UBERON:0001496") Annotation( "Wikipedia:Ascending_aorta") "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.") AnnotationAssertion(rdfs:label "ascending aorta development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17046,6 +22565,7 @@ SubClassOf( ObjectSomeValuesFrom( (descending aorta development) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dgh") Annotation( "MA:0002571") Annotation( "UBERON:0001514") Annotation( "Wikipedia:Descending_aorta") "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.") AnnotationAssertion(rdfs:label "descending aorta development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17054,12 +22574,14 @@ SubClassOf( ObjectSomeValuesFrom( (dorsal aorta development) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dgh") Annotation( "UBERON:0005805") Annotation( "Wikipedia:Aorta") Annotation( "ZFA:0000014") "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.") AnnotationAssertion(rdfs:label "dorsal aorta development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (aorta morphogenesis) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dgh") Annotation( "MA:0000062") Annotation( "UBERON:0000947") Annotation( "Wikipedia:Aorta") "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.") AnnotationAssertion(rdfs:label "aorta morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17067,6 +22589,7 @@ SubClassOf( ObjectSomeValuesFrom( (ascending aorta morphogenesis) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dgh") Annotation( "MA:0002570") Annotation( "UBERON:0001496") Annotation( "Wikipedia:Ascending_aorta") "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.") AnnotationAssertion(rdfs:label "ascending aorta morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17076,6 +22599,7 @@ SubClassOf( ObjectSomeValuesFrom( (descending aorta morphogenesis) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dgh") Annotation( "MA:0002571") Annotation( "UBERON:0001514") Annotation( "Wikipedia:Descending_aorta") "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.") AnnotationAssertion(rdfs:label "descending aorta morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17085,6 +22609,7 @@ SubClassOf( ObjectSomeValuesFrom( (dorsal aorta morphogenesis) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dgh") Annotation( "UBERON:0005805") Annotation( "Wikipedia:Aorta") Annotation( "ZFA:0000014") "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.") AnnotationAssertion(rdfs:label "dorsal aorta morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17092,6 +22617,7 @@ SubClassOf( ObjectSomeValuesFrom( (skeletal muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000188") Annotation( "GOC:BHF") Annotation( "GOC:vk") "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.") AnnotationAssertion(rdfs:label "skeletal muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17099,6 +22625,7 @@ SubClassOf( ObjectSomeValuesFrom( (steroid hormone secretion) +AnnotationAssertion(Annotation( "GOC:sl") "The regulated release of any steroid that acts as a hormone into the circulatory system.") AnnotationAssertion(rdfs:label "steroid hormone secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17106,11 +22633,13 @@ SubClassOf( (androgen secretion) +AnnotationAssertion(Annotation( "GOC:sl") "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates.") AnnotationAssertion(rdfs:label "androgen secretion") SubClassOf( ) # Class: (endodermal cell differentiation) +AnnotationAssertion(Annotation( "CL:0000223") Annotation( "GOC:yaf") Annotation( "PMID:17624332") "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.") AnnotationAssertion(rdfs:label "endodermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17118,12 +22647,14 @@ SubClassOf( ObjectSomeValuesFrom( (tendon development) +AnnotationAssertion(Annotation( "GOC:yaf") Annotation( "PMID:21412429") Annotation( "UBERON:0000043") "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.") AnnotationAssertion(rdfs:label "tendon development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (tendon formation) +AnnotationAssertion(Annotation( "GOC:yaf") Annotation( "PMID:17567668") Annotation( "UBERON:0000043") "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts.") AnnotationAssertion(rdfs:label "tendon formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17132,6 +22663,7 @@ SubClassOf( ObjectSomeValuesFrom( (osteoclast development) +AnnotationAssertion(Annotation( "CL:0000092") Annotation( "GOC:bf") Annotation( "GOC:yaf") "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.") AnnotationAssertion(rdfs:label "osteoclast development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17139,11 +22671,13 @@ SubClassOf( ObjectSomeValuesFrom( (direct ossification) +AnnotationAssertion(Annotation( "GO_REF:0000034") "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues.") AnnotationAssertion(rdfs:label "direct ossification") SubClassOf( ) # Class: (germ cell proliferation) +AnnotationAssertion(Annotation( "CL:0000586") Annotation( "GOC:kmv") "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population.") AnnotationAssertion(rdfs:label "germ cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17151,12 +22685,14 @@ SubClassOf( ObjectSomeValuesFrom( (dendritic cell homeostasis) +AnnotationAssertion(Annotation( "CL:0000451") Annotation( "GOC:uh") Annotation( "PMID:12570827") Annotation( "PMID:19176316") "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.") AnnotationAssertion(rdfs:label "dendritic cell homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (osteoclast maturation) +AnnotationAssertion(Annotation( "CL:0000092") Annotation( "GOC:pg") "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes.") AnnotationAssertion(rdfs:label "osteoclast maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17164,46 +22700,72 @@ SubClassOf( ObjectSomeValuesFrom( (muscle cell projection) +AnnotationAssertion(Annotation( "CL:0000187") Annotation( "GOC:kmv") Annotation( "PMID:15930100") Annotation( "PMID:22464329") "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.") AnnotationAssertion(rdfs:label "muscle cell projection") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (muscle cell projection membrane) +AnnotationAssertion(Annotation( "CL:0000187") Annotation( "GOC:kmv") Annotation( "PMID:15930100") Annotation( "PMID:22464329") "The portion of the plasma membrane surrounding a muscle cell projection.") AnnotationAssertion(rdfs:label "muscle cell projection membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (granulocyte activation) +AnnotationAssertion(Annotation( "CL:0000094") Annotation( "GOC:nhn") "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.") AnnotationAssertion(rdfs:label "granulocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (response to decreased oxygen levels) +AnnotationAssertion(Annotation( "GOC:al") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.") +AnnotationAssertion(rdfs:comment "This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'.") AnnotationAssertion(rdfs:label "response to decreased oxygen levels") SubClassOf( ) +# Class: (hepatocyte homeostasis) + +AnnotationAssertion(Annotation( "CL:0000182") Annotation( "GOC:nhn") Annotation( "PMID:19878874") "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules.") +AnnotationAssertion(rdfs:label "hepatocyte homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (epidermal stem cell homeostasis) +AnnotationAssertion(Annotation( "CL:1000428") Annotation( "GOC:nhn") Annotation( "PMID:17666529") "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells.") AnnotationAssertion(rdfs:label "epidermal stem cell homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (dendritic cell migration) +AnnotationAssertion(Annotation( "CL:0000451") Annotation( "GOC:nhn") Annotation( "PMID:19339990") "The movement of a dendritic cell within or between different tissues and organs of the body.") AnnotationAssertion(rdfs:label "dendritic cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (post-anal tail morphogenesis) + +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:kmv") Annotation( "Wikipedia:Chordate") "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.") +AnnotationAssertion(rdfs:label "post-anal tail morphogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) + # Class: (somatodendritic compartment) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:pad") "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.") AnnotationAssertion(rdfs:label "somatodendritic compartment") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (trunk neural crest cell migration) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:bf") Annotation( "GOC:mat") Annotation( "PMID:2387238") "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo.") AnnotationAssertion(rdfs:label "trunk neural crest cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17211,6 +22773,7 @@ SubClassOf( ObjectSomeValuesFrom( (Golgi membrane fusion) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:bf") Annotation( "PMID:12473691") "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane.") AnnotationAssertion(rdfs:label "Golgi membrane fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17218,6 +22781,8 @@ SubClassOf( ObjectSomeValuesFrom( (growth) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:ma") "The increase in size or mass of an entire organism, a part of an organism or a cell.") +AnnotationAssertion(rdfs:comment "See also the biological process term 'cell growth ; GO:0016049'.") AnnotationAssertion(rdfs:label "growth") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -17225,12 +22790,14 @@ SubClassOf( ObjectAllValuesFrom( (regulation of growth) +AnnotationAssertion(Annotation( "GOC:ems") Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.") AnnotationAssertion(rdfs:label "regulation of growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (locomotion) +AnnotationAssertion(Annotation( "GOC:dgh") "Self-propelled movement of a cell or organism from one location to another.") AnnotationAssertion(rdfs:label "locomotion") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -17239,12 +22806,14 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (regulation of locomotion) +AnnotationAssertion(Annotation( "GOC:ems") "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.") AnnotationAssertion(rdfs:label "regulation of locomotion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of locomotion) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.") AnnotationAssertion(rdfs:label "negative regulation of locomotion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17252,22 +22821,26 @@ SubClassOf( (regulation of multicellular organism growth) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:ems") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.") AnnotationAssertion(rdfs:label "regulation of multicellular organism growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of multicellular organism growth) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:ems") Annotation( "GOC:tb") "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.") AnnotationAssertion(rdfs:label "negative regulation of multicellular organism growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (embryonic cleavage) +AnnotationAssertion(Annotation( "GOC:clt") Annotation( "ISBN:0070524300") "The first few specialized divisions of an activated animal egg.") AnnotationAssertion(rdfs:label "embryonic cleavage") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of locomotion) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.") AnnotationAssertion(rdfs:label "positive regulation of locomotion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17275,11 +22848,13 @@ SubClassOf( (positive regulation of multicellular organism growth) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.") AnnotationAssertion(rdfs:label "positive regulation of multicellular organism growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of embryonic development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of embryonic development.") AnnotationAssertion(rdfs:label "positive regulation of embryonic development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17288,6 +22863,7 @@ SubClassOf( (regulation of meiotic nuclear division) +AnnotationAssertion(Annotation( "GOC:ems") Annotation( "GOC:ma") "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.") AnnotationAssertion(rdfs:label "regulation of meiotic nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17295,17 +22871,20 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of development, heterochronic) +AnnotationAssertion(Annotation( "PMID:9442909") "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.") AnnotationAssertion(rdfs:label "regulation of development, heterochronic") SubClassOf( ) # Class: (gliogenesis) +AnnotationAssertion(Annotation( "GOC:dgh") Annotation( "GOC:jid") "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.") AnnotationAssertion(rdfs:label "gliogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (glial cell growth) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") Annotation( "GOC:jid") "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.") AnnotationAssertion(rdfs:label "glial cell growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17313,6 +22892,7 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of catecholamine metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines.") AnnotationAssertion(rdfs:label "regulation of catecholamine metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17320,6 +22900,9 @@ SubClassOf( (intraciliary transport) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:kmv") Annotation( "PMID:17981739") Annotation( "PMID:18180368") Annotation( "PMID:22869374") "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.") +AnnotationAssertion( "Wikipedia:Intraflagellar_transport") +AnnotationAssertion(rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent.") AnnotationAssertion(rdfs:label "intraciliary transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17347,18 +22930,21 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (cell migration involved in gastrulation) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "PMID:16099638") "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).") AnnotationAssertion(rdfs:label "cell migration involved in gastrulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (germ-line stem cell division) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "PMID:2279698") "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.") AnnotationAssertion(rdfs:label "germ-line stem cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (T cell proliferation) +AnnotationAssertion(Annotation( "GOC:jl") "The expansion of a T cell population by cell division. Follows T cell activation.") AnnotationAssertion(rdfs:label "T cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17366,40 +22952,47 @@ SubClassOf( (positive regulation of T cell proliferation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the rate or extent of T cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of T cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of T cell homeostatic proliferation) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that activates or increases the rate or extent of resting T cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of T cell homeostatic proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (T cell activation) +AnnotationAssertion(Annotation( "GOC:mgi_curators") Annotation( "ISBN:0781735149") "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.") AnnotationAssertion(rdfs:label "T cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (macrophage activation) +AnnotationAssertion(Annotation( "GOC:mgi_curators") Annotation( "ISBN:0781735149") Annotation( "PMID:14506301") "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.") AnnotationAssertion(rdfs:label "macrophage activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (monocyte activation) +AnnotationAssertion(Annotation( "GOC:mgi_curators") Annotation( "ISBN:0781735149") "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.") AnnotationAssertion(rdfs:label "monocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (endothelial cell activation) +AnnotationAssertion(Annotation( "GOC:mgi_curators") Annotation( "ISBN:0781735149") Annotation( "PMID:12851652") Annotation( "PMID:14581484") "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.") AnnotationAssertion(rdfs:label "endothelial cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of cell population proliferation) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of cell proliferation.") AnnotationAssertion(rdfs:label "regulation of cell population proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17409,44 +23002,97 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (regulation of T cell proliferation) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of T cell proliferation.") AnnotationAssertion(rdfs:label "regulation of T cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of T cell proliferation) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that stops, prevents or reduces the rate or extent of T cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of T cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (lipoprotein metabolic process) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.") AnnotationAssertion(rdfs:label "lipoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (lipoprotein biosynthetic process) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.") AnnotationAssertion(rdfs:label "lipoprotein biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (lipoprotein catabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.") +AnnotationAssertion(rdfs:label "lipoprotein catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (nuclear outer membrane-endoplasmic reticulum membrane network) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:jl") Annotation( "GOC:mah") Annotation( "GOC:mcc") Annotation( "GOC:pr") Annotation( "GOC:vw") "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.") AnnotationAssertion(rdfs:label "nuclear outer membrane-endoplasmic reticulum membrane network") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (regulation of protein catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.") +AnnotationAssertion(rdfs:label "regulation of protein catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of protein catabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:kmv") Annotation( "GOC:obol") Annotation( "GO_REF:0000058") Annotation( "PMID:24785082") "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.") +AnnotationAssertion(rdfs:label "negative regulation of protein catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (cellular ketone metabolic process) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0787650153") "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.") +AnnotationAssertion(rdfs:label "cellular ketone metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (ketone biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.") +AnnotationAssertion(rdfs:label "ketone biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (ketone catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.") +AnnotationAssertion(rdfs:label "ketone catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (response to chemical) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "response to chemical") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (ribosome biogenesis) +AnnotationAssertion(Annotation( "GOC:ma") Annotation( "PMID:26404467") Annotation( "Wikipedia:Ribosome_biogenesis") "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.") AnnotationAssertion(rdfs:label "ribosome biogenesis") SubClassOf( ) # Class: (ribosome assembly) +AnnotationAssertion(Annotation( "GOC:ma") Annotation( "PMID:30467428") "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.") AnnotationAssertion(rdfs:label "ribosome assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17454,44 +23100,75 @@ SubClassOf( ObjectSomeValuesFrom( (taxis) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0192801023") "The directed movement of a motile cell or organism in response to an external stimulus.") +AnnotationAssertion( "Wikipedia:Taxis") AnnotationAssertion(rdfs:label "taxis") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of membrane potential) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_cardio") Annotation( "GOC:tb") Annotation( "ISBN:0198506732") "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.") AnnotationAssertion(rdfs:label "regulation of membrane potential") SubClassOf( ObjectSomeValuesFrom( )) # Class: (biogenic amine biosynthetic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0395825172") "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.") AnnotationAssertion(rdfs:label "biogenic amine biosynthetic process") SubClassOf( ) SubClassOf( ) +# Class: (cellular biogenic amine catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.") +AnnotationAssertion(rdfs:label "cellular biogenic amine catabolic process") +SubClassOf( ) + # Class: (norepinephrine metabolic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.") AnnotationAssertion(rdfs:label "norepinephrine metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (norepinephrine biosynthetic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.") AnnotationAssertion(rdfs:label "norepinephrine biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (norepinephrine catabolic process) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.") +AnnotationAssertion( "Wikipedia:Norepinephrine#Degradation") +AnnotationAssertion(rdfs:label "norepinephrine catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (catecholamine biosynthetic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.") +AnnotationAssertion( "Wikipedia:Catecholamines") AnnotationAssertion(rdfs:label "catecholamine biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (catecholamine catabolic process) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.") +AnnotationAssertion(rdfs:label "catecholamine catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (serotonin biosynthetic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.") +AnnotationAssertion( "Wikipedia:Serotonin") AnnotationAssertion(rdfs:label "serotonin biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (serotonin metabolic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.") AnnotationAssertion(rdfs:label "serotonin metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17499,20 +23176,36 @@ SubClassOf( ) SubClassOf( ) +# Class: (serotonin catabolic process) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.") +AnnotationAssertion(rdfs:label "serotonin catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (indole-containing compound metabolic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mah") "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton.") AnnotationAssertion(rdfs:label "indole-containing compound metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (indole-containing compound biosynthetic process) +AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton.") AnnotationAssertion(rdfs:label "indole-containing compound biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (indole-containing compound catabolic process) + +AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton.") +AnnotationAssertion(rdfs:label "indole-containing compound catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (photoreceptor cell development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.") AnnotationAssertion(rdfs:label "photoreceptor cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17520,6 +23213,7 @@ SubClassOf( ObjectSomeValuesFrom( (eye photoreceptor cell development) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0192800981") "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.") AnnotationAssertion(rdfs:label "eye photoreceptor cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17527,23 +23221,27 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of eye photoreceptor cell development) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of eye photoreceptor development.") AnnotationAssertion(rdfs:label "regulation of eye photoreceptor cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of eye photoreceptor cell development) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development.") AnnotationAssertion(rdfs:label "positive regulation of eye photoreceptor cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of eye photoreceptor cell development) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development.") AnnotationAssertion(rdfs:label "negative regulation of eye photoreceptor cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (neuron maturation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.") AnnotationAssertion(rdfs:label "neuron maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17551,28 +23249,53 @@ SubClassOf( ObjectSomeValuesFrom( (azurophil granule) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "PMID:17152095") Annotation( "PMID:28717070") Annotation( "PMID:5914694") Annotation( "WIKIPEDIA:Azurophilic_granule") "Primary lysosomal granule readily stainable with a Romanowsky stain.") AnnotationAssertion(rdfs:label "azurophil granule") SubClassOf( ) SubClassOf( ) +# Class: (zymogen granule) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.") +AnnotationAssertion(rdfs:label "zymogen granule") +SubClassOf( ) + +# Class: (zymogen granule membrane) + +AnnotationAssertion(Annotation( "GOC:jl") "The lipid bilayer surrounding a zymogen granule.") +AnnotationAssertion(rdfs:label "zymogen granule membrane") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (homeostatic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0395825172") "Any biological process involved in the maintenance of an internal steady state.") AnnotationAssertion(rdfs:label "homeostatic process") SubClassOf( ) +# Class: (glucose homeostasis) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.") +AnnotationAssertion(rdfs:label "glucose homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (MHC protein complex) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:jl") Annotation( "ISBN:0781735149") Annotation( "PMID:15928678") Annotation( "PMID:16153240") "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.") AnnotationAssertion(rdfs:label "MHC protein complex") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (MHC class II protein complex) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:jl") Annotation( "ISBN:0120781859") Annotation( "PMID:15928678") "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.") AnnotationAssertion(rdfs:label "MHC class II protein complex") SubClassOf( ) # Class: (actomyosin) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any complex of actin, myosin, and accessory proteins.") AnnotationAssertion(rdfs:label "actomyosin") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -17580,12 +23303,14 @@ SubClassOf( ObjectSomeValuesFrom( (retinal cone cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.") AnnotationAssertion(rdfs:label "retinal cone cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000187") Annotation( "GOC:go_curators") "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.") AnnotationAssertion(rdfs:label "muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17593,23 +23318,35 @@ SubClassOf( ObjectSomeValuesFrom( (defense response to bacterium) +AnnotationAssertion(Annotation( "GOC:jl") "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.") AnnotationAssertion(rdfs:label "defense response to bacterium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (amide transport) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "amide transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (amide transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other.") +AnnotationAssertion(rdfs:label "amide transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (lipoprotein transport) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "lipoprotein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of apoptotic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_apoptosis") "Any process that modulates the occurrence or rate of cell death by apoptotic process.") +AnnotationAssertion(rdfs:comment "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.") AnnotationAssertion(rdfs:label "regulation of apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -17618,34 +23355,41 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (cell projection) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "PMID:16318917") "A prolongation or process extending from a cell, e.g. a flagellum or axon.") AnnotationAssertion(rdfs:label "cell projection") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of Golgi to plasma membrane protein transport) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.") AnnotationAssertion(rdfs:label "regulation of Golgi to plasma membrane protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of Golgi to plasma membrane protein transport) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.") AnnotationAssertion(rdfs:label "negative regulation of Golgi to plasma membrane protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of Golgi to plasma membrane protein transport) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.") AnnotationAssertion(rdfs:label "positive regulation of Golgi to plasma membrane protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (Golgi to plasma membrane protein transport) +AnnotationAssertion(Annotation( "ISBN:0716731363") "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.") AnnotationAssertion(rdfs:label "Golgi to plasma membrane protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (neuron projection) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "PMID:3077060") "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.") +AnnotationAssertion( "NIF_Subcellular:sao867568886") AnnotationAssertion(rdfs:label "neuron projection") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -17655,6 +23399,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (chordate embryonic development) +AnnotationAssertion(Annotation( "GOC:mtg_sensu") "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.") AnnotationAssertion(rdfs:label "chordate embryonic development") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -17662,6 +23407,7 @@ SubClassOf( ObjectAllValuesFrom( (camera-type eye development) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.") AnnotationAssertion(rdfs:label "camera-type eye development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17671,6 +23417,8 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (myeloid dendritic cell differentiation) +AnnotationAssertion(Annotation( "CL:0000782") Annotation( "GOC:jl") "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.") +AnnotationAssertion( "Wikipedia:Dendritic_cell") AnnotationAssertion(rdfs:label "myeloid dendritic cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17678,6 +23426,10 @@ SubClassOf( (neuronal cell body) +AnnotationAssertion(Annotation( "GOC:go_curators") "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.") +AnnotationAssertion( "NIF_Subcellular:sao1044911821") +AnnotationAssertion( "Wikipedia:Soma_(biology)") +AnnotationAssertion(rdfs:comment "Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.") AnnotationAssertion(rdfs:label "neuronal cell body") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17686,42 +23438,53 @@ SubClassOf( ObjectSomeValuesFrom( (T cell homeostasis) +AnnotationAssertion(Annotation( "GOC:mgi_curators") Annotation( "ISBN:0781735149") "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus.") AnnotationAssertion(rdfs:label "T cell homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of macrophage activation) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency or rate of macrophage activation.") AnnotationAssertion(rdfs:label "regulation of macrophage activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of macrophage activation) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.") AnnotationAssertion(rdfs:label "negative regulation of macrophage activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of macrophage activation) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that stimulates, induces or increases the rate of macrophage activation.") AnnotationAssertion(rdfs:label "positive regulation of macrophage activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (peptide biosynthetic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide.") AnnotationAssertion(rdfs:label "peptide biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (extracellular structure organization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.") AnnotationAssertion(rdfs:label "extracellular structure organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of apoptotic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_apoptosis") "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.") +AnnotationAssertion(rdfs:comment "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.") AnnotationAssertion(rdfs:label "positive regulation of apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of apoptotic process) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_apoptosis") "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.") +AnnotationAssertion(rdfs:comment "This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.") AnnotationAssertion(rdfs:label "negative regulation of apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -17730,32 +23493,64 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (regulation of programmed cell death) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.") AnnotationAssertion(rdfs:label "regulation of programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of programmed cell death) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.") AnnotationAssertion(rdfs:label "positive regulation of programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of programmed cell death) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.") AnnotationAssertion(rdfs:label "negative regulation of programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (germ cell nucleus) +AnnotationAssertion(Annotation( "CL:0000586") Annotation( "GOC:go_curators") "The nucleus of a germ cell, a reproductive cell in multicellular organisms.") AnnotationAssertion(rdfs:label "germ cell nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (positive regulation of catalytic activity) + +AnnotationAssertion(Annotation( "GOC:ebc") Annotation( "GOC:jl") Annotation( "GOC:tb") Annotation( "GOC:vw") "Any process that activates or increases the activity of an enzyme.") +AnnotationAssertion(rdfs:label "positive regulation of catalytic activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of catalytic activity) + +AnnotationAssertion(Annotation( "GOC:ebc") Annotation( "GOC:jl") Annotation( "GOC:tb") Annotation( "GOC:vw") "Any process that stops or reduces the activity of an enzyme.") +AnnotationAssertion(rdfs:label "negative regulation of catalytic activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (surfactant homeostasis) +AnnotationAssertion(Annotation( "PMID:23708874") Annotation( "PMID:9751757") "Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid.") AnnotationAssertion(rdfs:label "surfactant homeostasis") SubClassOf( ) +# Class: (hindgut contraction) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_muscle") Annotation( "UBERON:0001046") "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine.") +AnnotationAssertion(rdfs:label "hindgut contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (regulation of hindgut contraction) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "UBERON:0001046") "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.") +AnnotationAssertion(rdfs:label "regulation of hindgut contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of translation by machinery localization) +AnnotationAssertion(Annotation( "GOC:jl") "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location.") AnnotationAssertion(rdfs:label "regulation of translation by machinery localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17763,22 +23558,36 @@ SubClassOf( (macromolecule metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.") AnnotationAssertion(rdfs:label "macromolecule metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (peptide catabolic process) + +AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.") +AnnotationAssertion(rdfs:label "peptide catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (response to external biotic stimulus) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.") AnnotationAssertion(rdfs:label "response to external biotic stimulus") SubClassOf( ) SubClassOf( ) # Class: (organelle) +AnnotationAssertion(Annotation( "GOC:go_curators") "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.") +AnnotationAssertion( "NIF_Subcellular:sao1539965131") +AnnotationAssertion( "Wikipedia:Organelle") AnnotationAssertion(rdfs:label "organelle") SubClassOf( ) # Class: (membrane-bounded organelle) +AnnotationAssertion(Annotation( "GOC:go_curators") "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.") +AnnotationAssertion( "NIF_Subcellular:sao414196390") AnnotationAssertion(rdfs:label "membrane-bounded organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17786,17 +23595,21 @@ DisjointClasses( (non-membrane-bounded organelle) +AnnotationAssertion(Annotation( "GOC:go_curators") "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.") +AnnotationAssertion( "NIF_Subcellular:sao1456184038") AnnotationAssertion(rdfs:label "non-membrane-bounded organelle") SubClassOf( ) # Class: (intracellular organelle) +AnnotationAssertion(Annotation( "GOC:go_curators") "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.") AnnotationAssertion(rdfs:label "intracellular organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) DisjointClasses( ) # Class: (extracellular organelle) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "PMID:9914479") "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.") AnnotationAssertion(rdfs:label "extracellular organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17804,37 +23617,44 @@ SubClassOf( ObjectSomeValuesFrom( (intracellular membrane-bounded organelle) +AnnotationAssertion(Annotation( "GOC:go_curators") "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.") AnnotationAssertion(rdfs:label "intracellular membrane-bounded organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (intracellular non-membrane-bounded organelle) +AnnotationAssertion(Annotation( "GOC:go_curators") "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.") AnnotationAssertion(rdfs:label "intracellular non-membrane-bounded organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (organelle lumen) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mah") "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.") AnnotationAssertion(rdfs:label "organelle lumen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein-containing complex disassembly) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.") AnnotationAssertion(rdfs:label "negative regulation of protein-containing complex disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein-containing complex disassembly) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.") AnnotationAssertion(rdfs:label "positive regulation of protein-containing complex disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of protein-containing complex disassembly) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.") AnnotationAssertion(rdfs:label "regulation of protein-containing complex disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (erythrocyte maturation) +AnnotationAssertion(Annotation( "GOC:devbiol") Annotation( "GOC:jl") "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.") AnnotationAssertion(rdfs:label "erythrocyte maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17842,12 +23662,14 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of protein-containing complex assembly) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of protein complex assembly.") AnnotationAssertion(rdfs:label "regulation of protein-containing complex assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of carbohydrate biosynthetic process) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates.") AnnotationAssertion(rdfs:label "regulation of carbohydrate biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17855,27 +23677,32 @@ SubClassOf( (extracellular non-membrane-bounded organelle) +AnnotationAssertion(Annotation( "GOC:jl") "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell.") AnnotationAssertion(rdfs:label "extracellular non-membrane-bounded organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of monoatomic ion transport) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "regulation of monoatomic ion transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of monoatomic ion transport) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "positive regulation of monoatomic ion transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of monoatomic ion transport) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "negative regulation of monoatomic ion transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (contractile muscle fiber) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0815316194") "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.") AnnotationAssertion(rdfs:label "contractile muscle fiber") SubClassOf( ) SubClassOf( ) @@ -17886,6 +23713,7 @@ SubClassOf( ObjectAllValuesFrom( (nucleate erythrocyte maturation) +AnnotationAssertion(Annotation( "GOC:devbiol") Annotation( "GOC:jl") "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus.") AnnotationAssertion(rdfs:label "nucleate erythrocyte maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17893,18 +23721,41 @@ SubClassOf( ObjectSomeValuesFrom( (nucleate erythrocyte differentiation) +AnnotationAssertion(Annotation( "GOC:jl") "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds.") AnnotationAssertion(rdfs:label "nucleate erythrocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (response to peptide hormone) +AnnotationAssertion(Annotation( "PMID:11027914") Annotation( "PMID:15134857") Annotation( "Wikipedia:Peptide_hormone") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.") AnnotationAssertion(rdfs:label "response to peptide hormone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (oxoacid metabolic process) + +AnnotationAssertion(Annotation( "Wikipedia:Oxyacid") "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).") +AnnotationAssertion(rdfs:label "oxoacid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (regulation of generation of precursor metabolites and energy) + +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.") +AnnotationAssertion(rdfs:label "regulation of generation of precursor metabolites and energy") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (regulation of carbohydrate catabolic process) + +AnnotationAssertion(Annotation( "GOC:mlg") "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates.") +AnnotationAssertion(rdfs:label "regulation of carbohydrate catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (pigmentation) +AnnotationAssertion(Annotation( "GOC:jl") "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.") AnnotationAssertion(rdfs:label "pigmentation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -17912,6 +23763,7 @@ SubClassOf( ObjectAllValuesFrom( (muscle adaptation) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") Annotation( "PMID:11181628") Annotation( "PMID:11449884") Annotation( "PMID:12605307") "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.") AnnotationAssertion(rdfs:label "muscle adaptation") SubClassOf( ) SubClassOf( ) @@ -17919,65 +23771,77 @@ SubClassOf( ObjectSomeValuesFrom( (skeletal muscle adaptation) +AnnotationAssertion(Annotation( "GOC:mtg_muscle") Annotation( "PMID:11181628") Annotation( "PMID:11449884") Annotation( "PMID:12605307") "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals.") AnnotationAssertion(rdfs:label "skeletal muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of muscle adaptation) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_muscle") "Any process that modulates the frequency, rate or extent of muscle adaptation.") AnnotationAssertion(rdfs:label "regulation of muscle adaptation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of neuron apoptotic process) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_apoptosis") "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.") AnnotationAssertion(rdfs:label "regulation of neuron apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of neuron apoptotic process) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_apoptosis") "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.") AnnotationAssertion(rdfs:label "negative regulation of neuron apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of neuron apoptotic process) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_apoptosis") "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of neuron apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (blood vessel endothelial cell migration) +AnnotationAssertion(Annotation( "PMID:11166264") "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis.") AnnotationAssertion(rdfs:label "blood vessel endothelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of blood vessel endothelial cell migration) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.") AnnotationAssertion(rdfs:label "regulation of blood vessel endothelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of blood vessel endothelial cell migration) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.") AnnotationAssertion(rdfs:label "positive regulation of blood vessel endothelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of blood vessel endothelial cell migration) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.") AnnotationAssertion(rdfs:label "negative regulation of blood vessel endothelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (endothelial cell migration) +AnnotationAssertion(Annotation( "GOC:go_curators") "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.") AnnotationAssertion(rdfs:label "endothelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of respiratory gaseous exchange) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.") AnnotationAssertion(rdfs:label "regulation of respiratory gaseous exchange") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (skin development) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "UBERON:0002097") "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.") AnnotationAssertion(rdfs:label "skin development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17990,6 +23854,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (skin morphogenesis) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "UBERON:0002097") "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.") AnnotationAssertion(rdfs:label "skin morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -17997,50 +23862,80 @@ SubClassOf( ObjectSomeValuesFrom( (amide metabolic process) +AnnotationAssertion(Annotation( "GOC:curators") "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "amide metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (amide biosynthetic process) +AnnotationAssertion(Annotation( "GOC:curators") "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.") AnnotationAssertion(rdfs:label "amide biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (amide catabolic process) + +AnnotationAssertion(Annotation( "GOC:curators") "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.") +AnnotationAssertion(rdfs:label "amide catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (ossification involved in bone maturation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:mtg_mpo") "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.") AnnotationAssertion(rdfs:label "ossification involved in bone maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (ossification involved in bone remodeling) +AnnotationAssertion(Annotation( "GOC:mtg_mpo") Annotation( "GO_REF:0000034") "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli.") AnnotationAssertion(rdfs:label "ossification involved in bone remodeling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein-containing complex organization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.") AnnotationAssertion(rdfs:label "protein-containing complex organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (glucan metabolic process) + +AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues.") +AnnotationAssertion(rdfs:label "glucan metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of system process) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.") AnnotationAssertion(rdfs:label "regulation of system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of digestive system process) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.") AnnotationAssertion(rdfs:label "regulation of digestive system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of endocrine process) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.") AnnotationAssertion(rdfs:label "regulation of endocrine process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (regulation of excretion) + +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity.") +AnnotationAssertion(rdfs:label "regulation of excretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (regulation of respiratory system process) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system.") AnnotationAssertion(rdfs:label "regulation of respiratory system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18048,60 +23943,128 @@ SubClassOf( (cellular component biogenesis) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.") AnnotationAssertion(rdfs:label "cellular component biogenesis") SubClassOf( ) # Class: (regulation of cellular component biogenesis) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.") AnnotationAssertion(rdfs:label "regulation of cellular component biogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of vacuole organization) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.") AnnotationAssertion(rdfs:label "regulation of vacuole organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cellular component biogenesis) +AnnotationAssertion(Annotation( "GOC:jl") "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.") AnnotationAssertion(rdfs:label "positive regulation of cellular component biogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of vacuole organization) +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.") AnnotationAssertion(rdfs:label "positive regulation of vacuole organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (membrane biogenesis) +AnnotationAssertion(Annotation( "GOC:jl") "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane.") AnnotationAssertion(rdfs:label "membrane biogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (negative regulation of molecular function) + +AnnotationAssertion(Annotation( "GO:jl") "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.") +AnnotationAssertion(rdfs:label "negative regulation of molecular function") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (positive regulation of molecular function) + +AnnotationAssertion(Annotation( "GO:jl") "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.") +AnnotationAssertion(rdfs:label "positive regulation of molecular function") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (translation initiation ternary complex) +AnnotationAssertion(Annotation( "GOC:jl") "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).") AnnotationAssertion(rdfs:label "translation initiation ternary complex") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cellular metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways by which individual cells transform chemical substances.") +AnnotationAssertion(rdfs:comment "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.") AnnotationAssertion(rdfs:label "cellular metabolic process") SubClassOf( ) SubClassOf( ) # Class: (primary metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.") +AnnotationAssertion( "Wikipedia:Primary_metabolite") AnnotationAssertion(rdfs:label "primary metabolic process") SubClassOf( ) +# Class: (cellular catabolic process) + +AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.") +AnnotationAssertion(rdfs:label "cellular catabolic process") +SubClassOf( ) +SubClassOf( ) + # Class: (cellular biosynthetic process) +AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.") +AnnotationAssertion(rdfs:comment "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.") AnnotationAssertion(rdfs:label "cellular biosynthetic process") SubClassOf( ) SubClassOf( ) +# Class: (intestinal lipid catabolic process) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "PMID:7018485") "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas.") +AnnotationAssertion(rdfs:label "intestinal lipid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (small molecule metabolic process) + +AnnotationAssertion(Annotation( "GOC:curators") Annotation( "GOC:pde") Annotation( "GOC:vw") "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.") +AnnotationAssertion(rdfs:comment "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.") +AnnotationAssertion(rdfs:label "small molecule metabolic process") +SubClassOf( ) + +# Class: (small molecule catabolic process) + +AnnotationAssertion(Annotation( "GOC:curators") Annotation( "GOC:vw") "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.") +AnnotationAssertion(rdfs:comment "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.") +AnnotationAssertion(rdfs:label "small molecule catabolic process") +SubClassOf( ) +SubClassOf( ) + +# Class: (small molecule biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:curators") Annotation( "GOC:pde") Annotation( "GOC:vw") "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.") +AnnotationAssertion(rdfs:comment "Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.") +AnnotationAssertion(rdfs:label "small molecule biosynthetic process") +SubClassOf( ) +SubClassOf( ) + # Class: (cell body) +AnnotationAssertion(Annotation( "GOC:go_curators") "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.") +AnnotationAssertion( "FBbt:00005107") +AnnotationAssertion( "FMA:67301") +AnnotationAssertion( "Wikipedia:Cell_body") +AnnotationAssertion(rdfs:comment "Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.") AnnotationAssertion(rdfs:label "cell body") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -18109,19 +24072,29 @@ SubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( ObjectComplementOf())) DisjointClasses( ObjectSomeValuesFrom( )) +# Class: (type B pancreatic cell proliferation) + +AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:yaf") "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin.") +AnnotationAssertion(rdfs:label "type B pancreatic cell proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (fibroblast apoptotic process) +AnnotationAssertion(Annotation( "CL:0000057") Annotation( "GOC:jl") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:yaf") "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.") AnnotationAssertion(rdfs:label "fibroblast apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein localization to cytoskeleton) +AnnotationAssertion(Annotation( "GOC:jl") "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.") AnnotationAssertion(rdfs:label "protein localization to cytoskeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (biological process involved in interspecies interaction between organisms) +AnnotationAssertion(Annotation( "GOC:cc") "Any process evolved to enable an interaction with an organism of a different species.") AnnotationAssertion(rdfs:label "biological process involved in interspecies interaction between organisms") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -18130,32 +24103,39 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (motile cilium assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000079") Annotation( "PMID:19776033") Annotation( "PMID:21129373") Annotation( "ZFIN:dsf") "The aggregation, arrangement and bonding together of a set of components to form a motile cilium.") AnnotationAssertion(rdfs:label "motile cilium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (dendritic cell proliferation) +AnnotationAssertion(Annotation( "CL:0000451") Annotation( "PMID:18469816") "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.") AnnotationAssertion(rdfs:label "dendritic cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (chondrocyte activation) +AnnotationAssertion(Annotation( "CL:0000138") Annotation( "GOC:jl") "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage.") AnnotationAssertion(rdfs:label "chondrocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (multi-organism reproductive process) +AnnotationAssertion(Annotation( "GOC:jl") "A biological process that directly contributes to the process of producing new individuals, involving another organism.") AnnotationAssertion(rdfs:label "multi-organism reproductive process") SubClassOf( ) # Class: (multi-multicellular organism process) +AnnotationAssertion(Annotation( "GOC:jl") "A multicellular organism process which involves another multicellular organism of the same or different species.") AnnotationAssertion(rdfs:label "multi-multicellular organism process") SubClassOf( ) # Class: (cilium organization) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:jl") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.") +AnnotationAssertion(rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent.") AnnotationAssertion(rdfs:label "cilium organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18164,41 +24144,48 @@ SubClassOf( ObjectAllValuesFrom( (lipoprotein localization) +AnnotationAssertion(Annotation( "GOC:jl") "Any process in which a lipoprotein is transported to, or maintained in, a specific location.") AnnotationAssertion(rdfs:label "lipoprotein localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lipoprotein localization to membrane) +AnnotationAssertion(Annotation( "GOC:jl") "A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane.") AnnotationAssertion(rdfs:label "lipoprotein localization to membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lipoprotein localization to outer membrane) +AnnotationAssertion(Annotation( "GOC:jl") "A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane.") AnnotationAssertion(rdfs:label "lipoprotein localization to outer membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (plasma membrane fusion) +AnnotationAssertion(Annotation( "GOC:elh") Annotation( "GOC:mtg_muscle") "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.") AnnotationAssertion(rdfs:label "plasma membrane fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of bone resorption) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).") AnnotationAssertion(rdfs:label "regulation of bone resorption") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (meiotic chromosome segregation) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mah") "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.") AnnotationAssertion(rdfs:label "meiotic chromosome segregation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (development of primary sexual characteristics) +AnnotationAssertion(Annotation( "GOC:ai") "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.") AnnotationAssertion(rdfs:label "development of primary sexual characteristics") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -18206,29 +24193,35 @@ SubClassOf( ObjectSomeValuesFrom( (cell fate commitment) +AnnotationAssertion(Annotation( "ISBN:0716731185") "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate.") +AnnotationAssertion(rdfs:comment "Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created.") AnnotationAssertion(rdfs:label "cell fate commitment") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cell-cell signaling involved in cell fate commitment) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.") AnnotationAssertion(rdfs:label "cell-cell signaling involved in cell fate commitment") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (establishment of protein localization) +AnnotationAssertion(Annotation( "GOC:bf") "The directed movement of a protein to a specific location.") AnnotationAssertion(rdfs:label "establishment of protein localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (establishment or maintenance of neuroblast polarity) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:mah") Annotation( "GOC:mtg_sensu") Annotation( "PMID:19375318") Annotation( "PMID:20066083") "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.") AnnotationAssertion(rdfs:label "establishment or maintenance of neuroblast polarity") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (establishment of neuroblast polarity) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:mtg_sensu") "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.") AnnotationAssertion(rdfs:label "establishment of neuroblast polarity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18236,6 +24229,9 @@ SubClassOf( (synapse) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "ISBN:0198506732") Annotation( "PMID:24619342") Annotation( "PMID:29383328") Annotation( "PMID:31998110") "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.") +AnnotationAssertion( "NIF_Subcellular:sao914572699") +AnnotationAssertion( "Wikipedia:Chemical_synapse") AnnotationAssertion(rdfs:label "synapse") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -18243,6 +24239,7 @@ SubClassOf( ObjectAllValuesFrom( (sarcomere organization) +AnnotationAssertion(Annotation( "GOC:bf") "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.") AnnotationAssertion(rdfs:label "sarcomere organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18250,38 +24247,46 @@ SubClassOf( ObjectSomeValuesFrom( (cell-cell junction organization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.") AnnotationAssertion(rdfs:label "cell-cell junction organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (CD4 biosynthetic process) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions.") AnnotationAssertion(rdfs:label "CD4 biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of CD4 production) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.") AnnotationAssertion(rdfs:label "regulation of CD4 production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of CD4 production) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.") AnnotationAssertion(rdfs:label "positive regulation of CD4 production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of CD4 production) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.") AnnotationAssertion(rdfs:label "negative regulation of CD4 production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (external encapsulating structure organization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell.") AnnotationAssertion(rdfs:label "external encapsulating structure organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (leukocyte activation) +AnnotationAssertion(Annotation( "GOC:add") "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.") +AnnotationAssertion( "Wikipedia:Immunologic_activation") AnnotationAssertion(rdfs:label "leukocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18291,18 +24296,21 @@ SubClassOf( ObjectAllValuesFrom( (fat cell differentiation) +AnnotationAssertion(Annotation( "CL:0000136") Annotation( "GOC:go_curators") "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.") AnnotationAssertion(rdfs:label "fat cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myoblast differentiation) +AnnotationAssertion(Annotation( "CL:0000056") Annotation( "GOC:go_curators") Annotation( "GOC:mtg_muscle") "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.") AnnotationAssertion(rdfs:label "myoblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (endothelial cell differentiation) +AnnotationAssertion(Annotation( "CL:0000115") Annotation( "GOC:go_curators") "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.") AnnotationAssertion(rdfs:label "endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18310,12 +24318,16 @@ SubClassOf( ObjectSomeValuesFrom( (bone resorption) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:10968780") "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.") +AnnotationAssertion( "Wikipedia:Bone_resorption") AnnotationAssertion(rdfs:label "bone resorption") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of T cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of T cell differentiation.") +AnnotationAssertion(rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.") AnnotationAssertion(rdfs:label "regulation of T cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18323,6 +24335,8 @@ SubClassOf( (negative regulation of T cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.") +AnnotationAssertion(rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.") AnnotationAssertion(rdfs:label "negative regulation of T cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18331,6 +24345,8 @@ SubClassOf( (positive regulation of T cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of T cell differentiation.") +AnnotationAssertion(rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.") AnnotationAssertion(rdfs:label "positive regulation of T cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18339,6 +24355,7 @@ SubClassOf( (regulation of cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.") AnnotationAssertion(rdfs:label "regulation of cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18346,6 +24363,7 @@ SubClassOf( (negative regulation of cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18354,6 +24372,7 @@ SubClassOf( (positive regulation of cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18362,36 +24381,43 @@ SubClassOf( (regulation of fat cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of adipocyte differentiation.") AnnotationAssertion(rdfs:label "regulation of fat cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of fat cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.") AnnotationAssertion(rdfs:label "negative regulation of fat cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of fat cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.") AnnotationAssertion(rdfs:label "positive regulation of fat cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of endothelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of endothelial cell differentiation.") AnnotationAssertion(rdfs:label "regulation of endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of endothelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of endothelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of epidermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of epidermal cell differentiation.") AnnotationAssertion(rdfs:label "regulation of epidermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18399,6 +24425,7 @@ SubClassOf( (negative regulation of epidermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of epidermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18407,6 +24434,7 @@ SubClassOf( (positive regulation of epidermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of epidermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18415,6 +24443,8 @@ SubClassOf( (regulation of lymphocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of lymphocyte differentiation.") +AnnotationAssertion(rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.") AnnotationAssertion(rdfs:label "regulation of lymphocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18422,6 +24452,8 @@ SubClassOf( (negative regulation of lymphocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.") +AnnotationAssertion(rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.") AnnotationAssertion(rdfs:label "negative regulation of lymphocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18430,6 +24462,8 @@ SubClassOf( (positive regulation of lymphocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.") +AnnotationAssertion(rdfs:comment "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.") AnnotationAssertion(rdfs:label "positive regulation of lymphocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18438,97 +24472,116 @@ SubClassOf( (regulation of myeloid cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of myeloid cell differentiation.") AnnotationAssertion(rdfs:label "regulation of myeloid cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of myeloid cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of myeloid cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myeloid cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of myeloid cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of erythrocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of erythrocyte differentiation.") AnnotationAssertion(rdfs:label "regulation of erythrocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of erythrocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.") AnnotationAssertion(rdfs:label "negative regulation of erythrocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of erythrocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.") AnnotationAssertion(rdfs:label "positive regulation of erythrocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of macrophage differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of macrophage differentiation.") AnnotationAssertion(rdfs:label "regulation of macrophage differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of macrophage differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.") AnnotationAssertion(rdfs:label "negative regulation of macrophage differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of macrophage differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of macrophage differentiation.") AnnotationAssertion(rdfs:label "positive regulation of macrophage differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of megakaryocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.") AnnotationAssertion(rdfs:label "regulation of megakaryocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of megakaryocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.") AnnotationAssertion(rdfs:label "negative regulation of megakaryocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of megakaryocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.") AnnotationAssertion(rdfs:label "positive regulation of megakaryocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of monocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of monocyte differentiation.") AnnotationAssertion(rdfs:label "regulation of monocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of monocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation.") AnnotationAssertion(rdfs:label "negative regulation of monocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of monocyte differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of monocyte differentiation.") AnnotationAssertion(rdfs:label "positive regulation of monocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of myoblast differentiation) +AnnotationAssertion(Annotation( "CL:0000056") Annotation( "GOC:go_curators") Annotation( "GOC:mtg_muscle") "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.") AnnotationAssertion(rdfs:label "regulation of myoblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myoblast differentiation) +AnnotationAssertion(Annotation( "CL:0000056") Annotation( "GOC:go_curators") Annotation( "GOC:mtg_muscle") "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.") AnnotationAssertion(rdfs:label "negative regulation of myoblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myoblast differentiation) +AnnotationAssertion(Annotation( "CL:0000056") Annotation( "GOC:go_curators") Annotation( "GOC:mtg_muscle") "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.") AnnotationAssertion(rdfs:label "positive regulation of myoblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of neuron differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of neuron differentiation.") AnnotationAssertion(rdfs:label "regulation of neuron differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -18536,37 +24589,44 @@ SubClassOf( ObjectAllValuesFrom( (negative regulation of neuron differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.") AnnotationAssertion(rdfs:label "negative regulation of neuron differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of neuron differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of neuron differentiation.") AnnotationAssertion(rdfs:label "positive regulation of neuron differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of osteoclast differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of osteoclast differentiation.") AnnotationAssertion(rdfs:label "regulation of osteoclast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of osteoclast differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.") AnnotationAssertion(rdfs:label "negative regulation of osteoclast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of osteoclast differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.") AnnotationAssertion(rdfs:label "positive regulation of osteoclast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of epidermis development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of epidermis development.") AnnotationAssertion(rdfs:label "regulation of epidermis development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of epidermis development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development.") AnnotationAssertion(rdfs:label "negative regulation of epidermis development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18574,6 +24634,7 @@ SubClassOf( (positive regulation of epidermis development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of epidermis development.") AnnotationAssertion(rdfs:label "positive regulation of epidermis development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18581,46 +24642,94 @@ SubClassOf( (regulation of glial cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of glia cell differentiation.") AnnotationAssertion(rdfs:label "regulation of glial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of glial cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of glial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of glial cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of glia cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of glial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (negative regulation of glycogen biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.") +AnnotationAssertion(rdfs:label "negative regulation of glycogen biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (negative regulation of gluconeogenesis) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.") +AnnotationAssertion(rdfs:label "negative regulation of gluconeogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of gluconeogenesis) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of gluconeogenesis.") +AnnotationAssertion(rdfs:label "positive regulation of gluconeogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (positive regulation of cilium assembly) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the formation of a cilium.") AnnotationAssertion(rdfs:label "positive regulation of cilium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (positive regulation of glycogen biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.") +AnnotationAssertion(rdfs:label "positive regulation of glycogen biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (positive regulation of translation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.") AnnotationAssertion(rdfs:label "positive regulation of translation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (positive regulation of protein catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.") +AnnotationAssertion(rdfs:label "positive regulation of protein catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (negative regulation of action potential) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.") AnnotationAssertion(rdfs:label "negative regulation of action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of action potential) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.") AnnotationAssertion(rdfs:label "positive regulation of action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of angiogenesis) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of angiogenesis.") AnnotationAssertion(rdfs:label "regulation of angiogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18628,6 +24737,7 @@ SubClassOf( (positive regulation of angiogenesis) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases angiogenesis.") AnnotationAssertion(rdfs:label "positive regulation of angiogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18635,16 +24745,19 @@ SubClassOf( (negative regulation of asymmetric cell division) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.") AnnotationAssertion(rdfs:label "negative regulation of asymmetric cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of asymmetric cell division) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of asymmetric cell division.") AnnotationAssertion(rdfs:label "positive regulation of asymmetric cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of ossification) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.") AnnotationAssertion(rdfs:label "positive regulation of ossification") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18652,22 +24765,26 @@ SubClassOf( (negative regulation of bone resorption) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.") AnnotationAssertion(rdfs:label "negative regulation of bone resorption") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of bone resorption) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of bone resorption.") AnnotationAssertion(rdfs:label "positive regulation of bone resorption") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cell adhesion) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of cell adhesion.") AnnotationAssertion(rdfs:label "positive regulation of cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cell cycle) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.") AnnotationAssertion(rdfs:label "negative regulation of cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18675,6 +24792,7 @@ SubClassOf( (positive regulation of cell cycle) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the rate or extent of progression through the cell cycle.") AnnotationAssertion(rdfs:label "positive regulation of cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18682,18 +24800,39 @@ SubClassOf( (negative regulation of endocytosis) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.") AnnotationAssertion(rdfs:label "negative regulation of endocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of endocytosis) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of endocytosis.") AnnotationAssertion(rdfs:label "positive regulation of endocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (negative regulation of glycogen catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.") +AnnotationAssertion(rdfs:label "negative regulation of glycogen catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of glycogen catabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.") +AnnotationAssertion(rdfs:label "positive regulation of glycogen catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (negative regulation of heart contraction) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.") AnnotationAssertion(rdfs:label "negative regulation of heart contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18701,6 +24840,7 @@ SubClassOf( (positive regulation of heart contraction) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of heart contraction.") AnnotationAssertion(rdfs:label "positive regulation of heart contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18708,6 +24848,7 @@ SubClassOf( (negative regulation of lipid metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.") AnnotationAssertion(rdfs:label "negative regulation of lipid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18715,6 +24856,7 @@ SubClassOf( (positive regulation of lipid metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.") AnnotationAssertion(rdfs:label "positive regulation of lipid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18722,12 +24864,14 @@ SubClassOf( (negative regulation of meiotic nuclear division) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.") AnnotationAssertion(rdfs:label "negative regulation of meiotic nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of meiotic nuclear division) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of meiosis.") AnnotationAssertion(rdfs:label "positive regulation of meiotic nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18737,6 +24881,7 @@ SubClassOf( ObjectSomeValuesFrom( (negative regulation of mitotic nuclear division) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.") AnnotationAssertion(rdfs:label "negative regulation of mitotic nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18744,48 +24889,56 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of mitotic nuclear division) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of mitosis.") AnnotationAssertion(rdfs:label "positive regulation of mitotic nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of striated muscle tissue development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.") AnnotationAssertion(rdfs:label "negative regulation of striated muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of striated muscle tissue development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of striated muscle development.") AnnotationAssertion(rdfs:label "positive regulation of striated muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of translational elongation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.") AnnotationAssertion(rdfs:label "negative regulation of translational elongation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of translational elongation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of translational elongation.") AnnotationAssertion(rdfs:label "positive regulation of translational elongation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of translational termination) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination.") AnnotationAssertion(rdfs:label "negative regulation of translational termination") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of translational termination) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of translational termination.") AnnotationAssertion(rdfs:label "positive regulation of translational termination") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of carbohydrate metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.") AnnotationAssertion(rdfs:label "negative regulation of carbohydrate metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18793,6 +24946,7 @@ SubClassOf( (positive regulation of carbohydrate metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.") AnnotationAssertion(rdfs:label "positive regulation of carbohydrate metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18800,6 +24954,7 @@ SubClassOf( (negative regulation of catecholamine metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.") AnnotationAssertion(rdfs:label "negative regulation of catecholamine metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18807,6 +24962,7 @@ SubClassOf( (positive regulation of catecholamine metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.") AnnotationAssertion(rdfs:label "positive regulation of catecholamine metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18814,6 +24970,7 @@ SubClassOf( (negative regulation of exocytosis) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.") AnnotationAssertion(rdfs:label "negative regulation of exocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18821,6 +24978,7 @@ SubClassOf( (positive regulation of exocytosis) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of exocytosis.") AnnotationAssertion(rdfs:label "positive regulation of exocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18828,6 +24986,7 @@ SubClassOf( (negative regulation of growth) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.") AnnotationAssertion(rdfs:label "negative regulation of growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18835,6 +24994,7 @@ SubClassOf( (positive regulation of growth) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.") AnnotationAssertion(rdfs:label "positive regulation of growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18842,16 +25002,19 @@ SubClassOf( (negative regulation of mitotic cell cycle) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.") AnnotationAssertion(rdfs:label "negative regulation of mitotic cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of mitotic cell cycle) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.") AnnotationAssertion(rdfs:label "positive regulation of mitotic cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of muscle contraction) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.") AnnotationAssertion(rdfs:label "negative regulation of muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18859,6 +25022,7 @@ SubClassOf( (positive regulation of muscle contraction) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of muscle contraction.") AnnotationAssertion(rdfs:label "positive regulation of muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18866,28 +25030,49 @@ SubClassOf( (negative regulation of nucleobase-containing compound metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.") AnnotationAssertion(rdfs:label "negative regulation of nucleobase-containing compound metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of nucleobase-containing compound metabolic process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.") AnnotationAssertion(rdfs:label "positive regulation of nucleobase-containing compound metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (negative regulation of steroid metabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.") +AnnotationAssertion(rdfs:label "negative regulation of steroid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of steroid metabolic process) + +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids.") +AnnotationAssertion(rdfs:label "positive regulation of steroid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (negative regulation of translational initiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.") AnnotationAssertion(rdfs:label "negative regulation of translational initiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of translational initiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of translational initiation.") AnnotationAssertion(rdfs:label "positive regulation of translational initiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of smooth muscle contraction) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.") AnnotationAssertion(rdfs:label "negative regulation of smooth muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18895,6 +25080,7 @@ SubClassOf( (positive regulation of smooth muscle contraction) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.") AnnotationAssertion(rdfs:label "positive regulation of smooth muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18902,6 +25088,7 @@ SubClassOf( (negative regulation of striated muscle contraction) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.") AnnotationAssertion(rdfs:label "negative regulation of striated muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18909,6 +25096,7 @@ SubClassOf( (positive regulation of striated muscle contraction) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of striated muscle contraction.") AnnotationAssertion(rdfs:label "positive regulation of striated muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18916,6 +25104,7 @@ SubClassOf( (negative regulation of embryonic development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.") AnnotationAssertion(rdfs:label "negative regulation of embryonic development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18924,56 +25113,81 @@ SubClassOf( (regulation of embryonic development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of embryonic development.") AnnotationAssertion(rdfs:label "regulation of embryonic development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of T cell homeostatic proliferation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of resting T cell proliferation.") AnnotationAssertion(rdfs:label "regulation of T cell homeostatic proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of T cell homeostatic proliferation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of T cell homeostatic proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (phenol-containing compound biosynthetic process) +AnnotationAssertion(Annotation( "GOC:ai") "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.") AnnotationAssertion(rdfs:label "phenol-containing compound biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (carboxylic acid biosynthetic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.") +AnnotationAssertion(rdfs:label "carboxylic acid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (carboxylic acid catabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.") +AnnotationAssertion(rdfs:label "carboxylic acid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (photoreceptor cell differentiation) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "ISBN:0198506732") "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster.") AnnotationAssertion(rdfs:label "photoreceptor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of photoreceptor cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.") AnnotationAssertion(rdfs:label "regulation of photoreceptor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of photoreceptor cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.") AnnotationAssertion(rdfs:label "negative regulation of photoreceptor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of photoreceptor cell differentiation) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.") AnnotationAssertion(rdfs:label "positive regulation of photoreceptor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (development of primary female sexual characteristics) +AnnotationAssertion(Annotation( "GOC:ai") "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion.") AnnotationAssertion(rdfs:label "development of primary female sexual characteristics") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (retinal rod cell development) +AnnotationAssertion(Annotation( "ISBN:0198506732") "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light.") AnnotationAssertion(rdfs:label "retinal rod cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18981,6 +25195,7 @@ SubClassOf( ObjectSomeValuesFrom( (retinal cone cell development) +AnnotationAssertion(Annotation( "ISBN:0198506732") "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision.") AnnotationAssertion(rdfs:label "retinal cone cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -18988,27 +25203,32 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of organ growth) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of growth of an organ of an organism.") AnnotationAssertion(rdfs:label "regulation of organ growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of organ growth) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:tb") "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.") AnnotationAssertion(rdfs:label "negative regulation of organ growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of organ growth) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.") AnnotationAssertion(rdfs:label "positive regulation of organ growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (lymphocyte activation) +AnnotationAssertion(Annotation( "GOC:mgi_curators") Annotation( "ISBN:0781735149") "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.") AnnotationAssertion(rdfs:label "lymphocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lymphocyte proliferation) +AnnotationAssertion(Annotation( "GOC:ai") "The expansion of a lymphocyte population by cell division.") AnnotationAssertion(rdfs:label "lymphocyte proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19016,18 +25236,21 @@ SubClassOf( (female sex differentiation) +AnnotationAssertion(Annotation( "GOC:bf") "The establishment of the sex of a female organism by physical differentiation.") AnnotationAssertion(rdfs:label "female sex differentiation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (retinal cell programmed cell death) +AnnotationAssertion(Annotation( "GOC:bf") "Programmed cell death that occurs in the developing retina.") AnnotationAssertion(rdfs:label "retinal cell programmed cell death") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (compound eye retinal cell programmed cell death) +AnnotationAssertion(Annotation( "PMID:12006672") "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium.") AnnotationAssertion(rdfs:label "compound eye retinal cell programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19035,36 +25258,52 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of retinal cell programmed cell death) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina.") AnnotationAssertion(rdfs:label "regulation of retinal cell programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of compound eye retinal cell programmed cell death) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.") AnnotationAssertion(rdfs:label "regulation of compound eye retinal cell programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of retinal cell programmed cell death) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina.") AnnotationAssertion(rdfs:label "positive regulation of retinal cell programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of retinal cell programmed cell death) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:tb") "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina.") AnnotationAssertion(rdfs:label "negative regulation of retinal cell programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of compound eye retinal cell programmed cell death) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.") AnnotationAssertion(rdfs:label "positive regulation of compound eye retinal cell programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of compound eye retinal cell programmed cell death) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.") AnnotationAssertion(rdfs:label "negative regulation of compound eye retinal cell programmed cell death") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (negative regulation of insulin secretion) + +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.") +AnnotationAssertion(rdfs:label "negative regulation of insulin secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (muscle cell cellular homeostasis) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:3091429") Annotation( "PMID:7781901") "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.") AnnotationAssertion(rdfs:label "muscle cell cellular homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -19073,11 +25312,13 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (acid secretion) +AnnotationAssertion(Annotation( "GOC:ai") "The controlled release of acid by a cell or a tissue.") AnnotationAssertion(rdfs:label "acid secretion") SubClassOf( ) # Class: (microtubule polymerization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:go_curators") "The addition of tubulin heterodimers to one or both ends of a microtubule.") AnnotationAssertion(rdfs:label "microtubule polymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19086,11 +25327,14 @@ SubClassOf( ObjectSomeValuesFrom( (bone remodeling) +AnnotationAssertion(Annotation( "GOC:curators") "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.") +AnnotationAssertion( "Wikipedia:Bone_remodeling") AnnotationAssertion(rdfs:label "bone remodeling") SubClassOf( ) # Class: (regulation of bone remodeling) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.") AnnotationAssertion(rdfs:label "regulation of bone remodeling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -19100,22 +25344,26 @@ SubClassOf( ObjectAllValuesFrom( (negative regulation of bone remodeling) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.") AnnotationAssertion(rdfs:label "negative regulation of bone remodeling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of bone remodeling) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of bone remodeling.") AnnotationAssertion(rdfs:label "positive regulation of bone remodeling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (hormone secretion) +AnnotationAssertion(Annotation( "ISBN:0198506732") "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.") AnnotationAssertion(rdfs:label "hormone secretion") SubClassOf( ) SubClassOf( ) # Class: (regulation of hormone secretion) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.") AnnotationAssertion(rdfs:label "regulation of hormone secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19125,6 +25373,7 @@ SubClassOf( (positive regulation of hormone secretion) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.") AnnotationAssertion(rdfs:label "positive regulation of hormone secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19134,6 +25383,7 @@ SubClassOf( (negative regulation of hormone secretion) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.") AnnotationAssertion(rdfs:label "negative regulation of hormone secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19143,6 +25393,7 @@ SubClassOf( (positive regulation of lipid biosynthetic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.") AnnotationAssertion(rdfs:label "positive regulation of lipid biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19151,6 +25402,7 @@ SubClassOf( (regulation of lipid biosynthetic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.") AnnotationAssertion(rdfs:label "regulation of lipid biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19158,54 +25410,78 @@ SubClassOf( (secretion) +AnnotationAssertion(Annotation( "GOC:ai") "The controlled release of a substance by a cell or a tissue.") AnnotationAssertion(rdfs:label "secretion") SubClassOf( ) # Class: (intracellular transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of substances within a cell.") AnnotationAssertion(rdfs:label "intracellular transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (carboxylic acid transport) + +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).") +AnnotationAssertion(rdfs:label "carboxylic acid transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (carboxylic acid transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:ai") "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).") +AnnotationAssertion(Annotation(rdfs:label "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane") "Reactome:R-HSA-390347") +AnnotationAssertion(rdfs:label "carboxylic acid transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vesicle transport along microtubule) +AnnotationAssertion(Annotation( "GOC:ecd") Annotation( "GOC:rl") "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.") AnnotationAssertion(rdfs:label "vesicle transport along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (embryonic eye morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.") AnnotationAssertion(rdfs:label "embryonic eye morphogenesis") SubClassOf( ) SubClassOf( ) # Class: (developmental pigmentation) +AnnotationAssertion(Annotation( "ISBN:0582227089") "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.") AnnotationAssertion(rdfs:label "developmental pigmentation") SubClassOf( ) # Class: (regulation of developmental pigmentation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.") AnnotationAssertion(rdfs:label "regulation of developmental pigmentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of developmental pigmentation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.") AnnotationAssertion(rdfs:label "negative regulation of developmental pigmentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of developmental pigmentation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.") AnnotationAssertion(rdfs:label "positive regulation of developmental pigmentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (somatic stem cell division) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "ISBN:0582227089") "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line.") AnnotationAssertion(rdfs:label "somatic stem cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (female germ-line stem cell asymmetric division) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_sensu") "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.") AnnotationAssertion(rdfs:label "female germ-line stem cell asymmetric division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -19214,63 +25490,74 @@ SubClassOf( ObjectAllValuesFrom( (fibroblast proliferation) +AnnotationAssertion(Annotation( "GOC:jid") "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.") AnnotationAssertion(rdfs:label "fibroblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of fibroblast proliferation) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.") AnnotationAssertion(rdfs:label "regulation of fibroblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of fibroblast proliferation) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.") AnnotationAssertion(rdfs:label "positive regulation of fibroblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of fibroblast proliferation) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.") AnnotationAssertion(rdfs:label "negative regulation of fibroblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (Golgi vesicle transport) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "ISBN:0716731363") Annotation( "PMID:10219233") "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.") AnnotationAssertion(rdfs:label "Golgi vesicle transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (Golgi vesicle budding) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "ISBN:0716731363") Annotation( "PMID:10219233") "The evagination of the Golgi membrane, resulting in formation of a vesicle.") AnnotationAssertion(rdfs:label "Golgi vesicle budding") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vesicle targeting, to, from or within Golgi) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mah") Annotation( "ISBN:0716731363") Annotation( "PMID:10219233") "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation.") AnnotationAssertion(rdfs:label "vesicle targeting, to, from or within Golgi") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of vesicle targeting, to, from or within Golgi) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mah") Annotation( "ISBN:0716731363") Annotation( "PMID:10219233") "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus.") AnnotationAssertion(rdfs:label "regulation of vesicle targeting, to, from or within Golgi") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (norepinephrine secretion) +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "GOC:jid") "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system.") AnnotationAssertion(rdfs:label "norepinephrine secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (macrophage chemotaxis) +AnnotationAssertion(Annotation( "GOC:jid") "The movement of a macrophage in response to an external stimulus.") AnnotationAssertion(rdfs:label "macrophage chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lymphocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:hjd") Annotation( "GOC:jid") Annotation( "PMID:12391252") "The directed movement of a lymphocyte in response to an external stimulus.") AnnotationAssertion(rdfs:label "lymphocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19278,12 +25565,14 @@ SubClassOf( (elastic fiber assembly) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "PMID:10841810") Annotation( "PMID:12615674") "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching.") AnnotationAssertion(rdfs:label "elastic fiber assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (vesicle fusion with Golgi apparatus) +AnnotationAssertion(Annotation( "GOC:jid") "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi.") AnnotationAssertion(rdfs:label "vesicle fusion with Golgi apparatus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19291,18 +25580,21 @@ SubClassOf( ObjectSomeValuesFrom( (organelle fusion) +AnnotationAssertion(Annotation( "GOC:jid") "The creation of a single organelle from two or more organelles.") AnnotationAssertion(rdfs:label "organelle fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (organelle fission) +AnnotationAssertion(Annotation( "GOC:jid") "The creation of two or more organelles by division of one organelle.") AnnotationAssertion(rdfs:label "organelle fission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lung alveolus development) +AnnotationAssertion(Annotation( "GOC:mtg_lung") Annotation( "PMID:9751757") "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.") AnnotationAssertion(rdfs:label "lung alveolus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19311,28 +25603,33 @@ SubClassOf( ObjectSomeValuesFrom( (nuclear membrane fusion involved in karyogamy) +AnnotationAssertion(Annotation( "GOC:jid") "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei.") AnnotationAssertion(rdfs:label "nuclear membrane fusion involved in karyogamy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (organelle inheritance) +AnnotationAssertion(Annotation( "GOC:jid") "The partitioning of organelles between daughter cells at cell division.") AnnotationAssertion(rdfs:label "organelle inheritance") SubClassOf( ) # Class: (Golgi inheritance) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "PMID:12851069") "The partitioning of Golgi apparatus between daughter cells at cell division.") AnnotationAssertion(rdfs:label "Golgi inheritance") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (axial mesoderm development) +AnnotationAssertion(Annotation( "GOC:dgh") "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.") AnnotationAssertion(rdfs:label "axial mesoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (axial mesoderm morphogenesis) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process in which the anatomical structures of the axial mesoderm are generated and organized.") AnnotationAssertion(rdfs:label "axial mesoderm morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19340,6 +25637,7 @@ SubClassOf( ObjectSomeValuesFrom( (axial mesoderm formation) +AnnotationAssertion(Annotation( "GOC:dgh") "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.") AnnotationAssertion(rdfs:label "axial mesoderm formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19347,6 +25645,7 @@ SubClassOf( ObjectSomeValuesFrom( (mesoderm morphogenesis) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process in which the anatomical structures of the mesoderm are generated and organized.") AnnotationAssertion(rdfs:label "mesoderm morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19354,6 +25653,7 @@ SubClassOf( ObjectSomeValuesFrom( (mesodermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:dgh") "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.") AnnotationAssertion(rdfs:label "mesodermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19361,12 +25661,14 @@ SubClassOf( ObjectSomeValuesFrom( (paraxial mesoderm development) +AnnotationAssertion(Annotation( "GOC:dgh") "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.") AnnotationAssertion(rdfs:label "paraxial mesoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (paraxial mesoderm morphogenesis) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process in which the anatomical structures of the paraxial mesoderm are generated and organized.") AnnotationAssertion(rdfs:label "paraxial mesoderm morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19374,6 +25676,7 @@ SubClassOf( ObjectSomeValuesFrom( (paraxial mesoderm formation) +AnnotationAssertion(Annotation( "GOC:dgh") "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.") AnnotationAssertion(rdfs:label "paraxial mesoderm formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19381,12 +25684,14 @@ SubClassOf( ObjectSomeValuesFrom( (lateral mesoderm development) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "lateral mesoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lateral mesoderm morphogenesis) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process in which the anatomical structures of the lateral mesoderm are generated and organized.") AnnotationAssertion(rdfs:label "lateral mesoderm morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19394,6 +25699,7 @@ SubClassOf( ObjectSomeValuesFrom( (lateral mesoderm formation) +AnnotationAssertion(Annotation( "GOC:jid") "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts.") AnnotationAssertion(rdfs:label "lateral mesoderm formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19401,12 +25707,14 @@ SubClassOf( ObjectSomeValuesFrom( (intermediate mesoderm development) +AnnotationAssertion(Annotation( "GOC:dgh") "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.") AnnotationAssertion(rdfs:label "intermediate mesoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (intermediate mesoderm morphogenesis) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process in which the anatomical structures of the intermediate mesoderm are generated and organized.") AnnotationAssertion(rdfs:label "intermediate mesoderm morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19414,6 +25722,7 @@ SubClassOf( ObjectSomeValuesFrom( (intermediate mesoderm formation) +AnnotationAssertion(Annotation( "GOC:dgh") "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts.") AnnotationAssertion(rdfs:label "intermediate mesoderm formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19421,6 +25730,7 @@ SubClassOf( ObjectSomeValuesFrom( (cell development) +AnnotationAssertion(Annotation( "GOC:go_curators") "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place.") AnnotationAssertion(rdfs:label "cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19429,6 +25739,7 @@ SubClassOf( ObjectSomeValuesFrom( (cell maturation) +AnnotationAssertion(Annotation( "GOC:go_curators") "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state.") AnnotationAssertion(rdfs:label "cell maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19437,6 +25748,8 @@ SubClassOf( ObjectSomeValuesFrom( (oogenesis) +AnnotationAssertion(Annotation( "GOC:kmv") Annotation( "GOC:mtg_sensu") Annotation( "GOC:pr") "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.") +AnnotationAssertion( "Wikipedia:Oogenesis") AnnotationAssertion(rdfs:label "oogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19447,6 +25760,7 @@ SubClassOf( ObjectAllValuesFrom( (autonomic nervous system development) +AnnotationAssertion(Annotation( "FMA:9905") Annotation( "GOC:jid") Annotation( "GOC:sr") "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands.") AnnotationAssertion(rdfs:label "autonomic nervous system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19454,6 +25768,7 @@ SubClassOf( ObjectSomeValuesFrom( (sympathetic nervous system development) +AnnotationAssertion(Annotation( "FMA:9906") Annotation( "GOC:jid") Annotation( "GOC:sr") "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter.") AnnotationAssertion(rdfs:label "sympathetic nervous system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19461,17 +25776,21 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of timing of cell differentiation) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:tb") "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development.") AnnotationAssertion(rdfs:label "regulation of timing of cell differentiation") SubClassOf( ) SubClassOf( ) # Class: (animal organ development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.") +AnnotationAssertion( "Wikipedia:Organogenesis") AnnotationAssertion(rdfs:label "animal organ development") SubClassOf( ) # Class: (blood vessel morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.") AnnotationAssertion(rdfs:label "blood vessel morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19481,23 +25800,43 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of biological process) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.") AnnotationAssertion(rdfs:label "positive regulation of biological process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of biological process) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.") AnnotationAssertion(rdfs:label "negative regulation of biological process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (positive regulation of behavior) + +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:pr") "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.") +AnnotationAssertion(rdfs:label "positive regulation of behavior") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (negative regulation of behavior) + +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:pr") "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.") +AnnotationAssertion(rdfs:label "negative regulation of behavior") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (positive regulation of cellular process) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.") AnnotationAssertion(rdfs:label "positive regulation of cellular process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cellular process) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.") AnnotationAssertion(rdfs:label "negative regulation of cellular process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19505,13 +25844,22 @@ SubClassOf( (hematopoietic or lymphoid organ development) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:rl") Annotation( "ISBN:0781735149") "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.") AnnotationAssertion(rdfs:label "hematopoietic or lymphoid organ development") SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (spleen development) + +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.") +AnnotationAssertion(rdfs:label "spleen development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (bone marrow development) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "bone marrow development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19519,12 +25867,14 @@ SubClassOf( ObjectSomeValuesFrom( (response to steroid hormone) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.") AnnotationAssertion(rdfs:label "response to steroid hormone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (digestive tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "PMID:12618131") "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.") AnnotationAssertion(rdfs:label "digestive tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19533,6 +25883,7 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic organ morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.") AnnotationAssertion(rdfs:label "embryonic organ morphogenesis") SubClassOf( ) SubClassOf( ) @@ -19540,6 +25891,7 @@ SubClassOf( ObjectSomeValuesFrom( (digestive tract development) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.") AnnotationAssertion(rdfs:label "digestive tract development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19548,6 +25900,7 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic organ development) +AnnotationAssertion(Annotation( "GOC:jid") "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.") AnnotationAssertion(rdfs:label "embryonic organ development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19556,6 +25909,7 @@ SubClassOf( ObjectSomeValuesFrom( (notochord morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.") AnnotationAssertion(rdfs:label "notochord morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19563,12 +25917,14 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of post-embryonic development) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.") AnnotationAssertion(rdfs:label "regulation of post-embryonic development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of post-embryonic development) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.") AnnotationAssertion(rdfs:label "negative regulation of post-embryonic development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19577,6 +25933,7 @@ SubClassOf( (positive regulation of post-embryonic development) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.") AnnotationAssertion(rdfs:label "positive regulation of post-embryonic development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19585,12 +25942,16 @@ SubClassOf( (regulation of response to stimulus) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "regulation of response to stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of response to stimulus) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "positive regulation of response to stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19598,6 +25959,8 @@ SubClassOf( (negative regulation of response to stimulus) +AnnotationAssertion(Annotation( "GOC:jid") "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "negative regulation of response to stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19605,6 +25968,7 @@ SubClassOf( (developmental cell growth) +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:isa_complete") "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.") AnnotationAssertion(rdfs:label "developmental cell growth") SubClassOf( ) SubClassOf( ) @@ -19612,11 +25976,13 @@ SubClassOf( ObjectSomeValuesFrom( (developmental growth) +AnnotationAssertion(Annotation( "GOC:go_curators") "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.") AnnotationAssertion(rdfs:label "developmental growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (eye morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_sensu") "The process in which the anatomical structures of the eye are generated and organized.") AnnotationAssertion(rdfs:label "eye morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19624,6 +25990,7 @@ SubClassOf( ObjectSomeValuesFrom( (camera-type eye morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_sensu") "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.") AnnotationAssertion(rdfs:label "camera-type eye morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19631,6 +25998,7 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic camera-type eye morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_sensu") "The process in which the anatomical structures of the eye are generated and organized during embryonic development.") AnnotationAssertion(rdfs:label "embryonic camera-type eye morphogenesis") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -19638,6 +26006,7 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_sensu") "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.") AnnotationAssertion(rdfs:label "embryonic morphogenesis") SubClassOf( ) SubClassOf( ) @@ -19645,6 +26014,7 @@ SubClassOf( ObjectSomeValuesFrom( (oocyte development) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.") AnnotationAssertion(rdfs:label "oocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19652,6 +26022,7 @@ SubClassOf( ObjectSomeValuesFrom( (oocyte morphogenesis) +AnnotationAssertion(Annotation( "GOC:go_curators") "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte.") AnnotationAssertion(rdfs:label "oocyte morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19662,6 +26033,7 @@ SubClassOf( ObjectAllValuesFrom( (reproductive structure development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") Annotation( "GOC:jid") "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.") AnnotationAssertion(rdfs:label "reproductive structure development") SubClassOf( ) SubClassOf( ) @@ -19669,11 +26041,13 @@ SubClassOf( ObjectSomeValuesFrom( (multicellular organismal reproductive process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:tb") "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.") AnnotationAssertion(rdfs:label "multicellular organismal reproductive process") SubClassOf( ) # Class: (myoblast development) +AnnotationAssertion(Annotation( "CL:0000056") Annotation( "GOC:dph") Annotation( "GOC:mtg_muscle") "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.") AnnotationAssertion(rdfs:label "myoblast development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19681,6 +26055,7 @@ SubClassOf( ObjectSomeValuesFrom( (myoblast maturation) +AnnotationAssertion(Annotation( "CL:0000056") Annotation( "GOC:dph") Annotation( "GOC:mtg_muscle") "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.") AnnotationAssertion(rdfs:label "myoblast maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19688,6 +26063,7 @@ SubClassOf( ObjectSomeValuesFrom( (skeletal muscle tissue growth) +AnnotationAssertion(Annotation( "GOC:lm") Annotation( "PMID:15726494") Annotation( "PMID:15907921") "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size.") AnnotationAssertion(rdfs:label "skeletal muscle tissue growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19695,39 +26071,46 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of skeletal muscle tissue growth) +AnnotationAssertion(Annotation( "GOC:lm") Annotation( "PMID:15726494") Annotation( "PMID:15907921") "Any process that modulates the frequency, rate or extent of skeletal muscle growth.") AnnotationAssertion(rdfs:label "regulation of skeletal muscle tissue growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of skeletal muscle tissue growth) +AnnotationAssertion(Annotation( "GOC:lm") Annotation( "PMID:15726494") Annotation( "PMID:15907921") "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth.") AnnotationAssertion(rdfs:label "negative regulation of skeletal muscle tissue growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of skeletal muscle tissue growth) +AnnotationAssertion(Annotation( "GOC:lm") Annotation( "PMID:15726494") Annotation( "PMID:15907921") "Any process that activates, maintains or increases the rate of skeletal muscle growth.") AnnotationAssertion(rdfs:label "positive regulation of skeletal muscle tissue growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of muscle organ development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of muscle development.") AnnotationAssertion(rdfs:label "regulation of muscle organ development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of muscle organ development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.") AnnotationAssertion(rdfs:label "negative regulation of muscle organ development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of muscle organ development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates, maintains or increases the rate of muscle development.") AnnotationAssertion(rdfs:label "positive regulation of muscle organ development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of developmental growth) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of developmental growth.") AnnotationAssertion(rdfs:label "regulation of developmental growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19735,6 +26118,7 @@ SubClassOf( (positive regulation of developmental growth) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates, maintains or increases the rate of developmental growth.") AnnotationAssertion(rdfs:label "positive regulation of developmental growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19743,6 +26127,7 @@ SubClassOf( (negative regulation of developmental growth) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.") AnnotationAssertion(rdfs:label "negative regulation of developmental growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19751,21 +26136,25 @@ SubClassOf( (regulation of skeletal muscle tissue development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.") AnnotationAssertion(rdfs:label "regulation of skeletal muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of skeletal muscle tissue development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.") AnnotationAssertion(rdfs:label "negative regulation of skeletal muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of skeletal muscle tissue development) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates, maintains or increases the rate of skeletal muscle tissue development.") AnnotationAssertion(rdfs:label "positive regulation of skeletal muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (muscle organ morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") "The process in which the anatomical structures of muscle are generated and organized.") AnnotationAssertion(rdfs:label "muscle organ morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19773,6 +26162,7 @@ SubClassOf( ObjectSomeValuesFrom( (animal organ formation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ.") AnnotationAssertion(rdfs:label "animal organ formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19781,33 +26171,40 @@ SubClassOf( ObjectSomeValuesFrom( (anatomical structure formation involved in morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:tb") "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.") +AnnotationAssertion(rdfs:comment "Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense.") AnnotationAssertion(rdfs:label "anatomical structure formation involved in morphogenesis") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (smooth muscle cell proliferation) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:ebc") Annotation( "PMID:1840698") "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.") AnnotationAssertion(rdfs:label "smooth muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of smooth muscle cell proliferation) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:ebc") "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.") AnnotationAssertion(rdfs:label "regulation of smooth muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of smooth muscle cell proliferation) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:ebc") "Any process that activates or increases the rate or extent of smooth muscle cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of smooth muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of smooth muscle cell proliferation) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:ebc") "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of smooth muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (neuron development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.") AnnotationAssertion(rdfs:label "neuron development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19815,17 +26212,20 @@ SubClassOf( ObjectSomeValuesFrom( (cell morphogenesis involved in neuron differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.") AnnotationAssertion(rdfs:label "cell morphogenesis involved in neuron differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (generation of neurons) +AnnotationAssertion(Annotation( "GOC:nln") "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.") AnnotationAssertion(rdfs:label "generation of neurons") SubClassOf( ) # Class: (skeletal system morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:dsf") Annotation( "GOC:jid") Annotation( "GOC:tb") "The process in which the anatomical structures of the skeleton are generated and organized.") AnnotationAssertion(rdfs:label "skeletal system morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19833,6 +26233,7 @@ SubClassOf( ObjectSomeValuesFrom( (tissue morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") "The process in which the anatomical structures of a tissue are generated and organized.") AnnotationAssertion(rdfs:label "tissue morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19841,12 +26242,14 @@ SubClassOf( ObjectSomeValuesFrom( (epidermis morphogenesis) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "UBERON:0001003") "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.") AnnotationAssertion(rdfs:label "epidermis morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (system development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.") AnnotationAssertion(rdfs:label "system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19854,6 +26257,7 @@ SubClassOf( ObjectSomeValuesFrom( (gland development) +AnnotationAssertion(Annotation( "GOC:jid") "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.") AnnotationAssertion(rdfs:label "gland development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19861,6 +26265,7 @@ SubClassOf( (appendage development) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:rc") "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.") AnnotationAssertion(rdfs:label "appendage development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19869,6 +26274,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac muscle tissue development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:lm") "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "cardiac muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19876,6 +26282,7 @@ SubClassOf( ObjectSomeValuesFrom( (skeletal muscle fiber development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:ef") Annotation( "GOC:jid") Annotation( "GOC:lm") Annotation( "GOC:mtg_muscle") "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.") AnnotationAssertion(rdfs:label "skeletal muscle fiber development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19883,12 +26290,14 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of skeletal muscle fiber development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:mtg_muscle") Annotation( "GOC:sm") "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.") AnnotationAssertion(rdfs:label "regulation of skeletal muscle fiber development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of skeletal muscle fiber development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:lm") Annotation( "GOC:mtg_muscle") "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.") AnnotationAssertion(rdfs:label "positive regulation of skeletal muscle fiber development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19896,30 +26305,35 @@ SubClassOf( (negative regulation of skeletal muscle fiber development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:lm") Annotation( "GOC:mtg_muscle") "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.") AnnotationAssertion(rdfs:label "negative regulation of skeletal muscle fiber development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (smooth muscle tissue development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:lm") "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "smooth muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (compound eye development) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_sensu") Annotation( "Wikipedia:Eye") "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.") AnnotationAssertion(rdfs:label "compound eye development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (pigment granule organization) +AnnotationAssertion(Annotation( "GOC:rc") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule.") AnnotationAssertion(rdfs:label "pigment granule organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (branching morphogenesis of an epithelial tube) +AnnotationAssertion(Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.") AnnotationAssertion(rdfs:label "branching morphogenesis of an epithelial tube") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19928,6 +26342,7 @@ SubClassOf( ObjectSomeValuesFrom( (branching morphogenesis of a nerve) +AnnotationAssertion(Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).") AnnotationAssertion(rdfs:label "branching morphogenesis of a nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19935,22 +26350,26 @@ SubClassOf( ObjectSomeValuesFrom( (mesenchymal cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.") AnnotationAssertion(rdfs:label "mesenchymal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (pigment granule) +AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mh") "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes.") AnnotationAssertion(rdfs:label "pigment granule") SubClassOf( ) # Class: (tissue remodeling) +AnnotationAssertion(Annotation( "GOC:ebc") "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.") AnnotationAssertion(rdfs:label "tissue remodeling") SubClassOf( ) # Class: (animal organ maturation) +AnnotationAssertion(Annotation( "GOC:curators") "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions.") AnnotationAssertion(rdfs:label "animal organ maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19958,6 +26377,7 @@ SubClassOf( ObjectSomeValuesFrom( (genitalia development) +AnnotationAssertion(Annotation( "GOC:jid") "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "genitalia development") SubClassOf( ) SubClassOf( ) @@ -19966,12 +26386,14 @@ SubClassOf( ObjectSomeValuesFrom( (neuron projection morphogenesis) +AnnotationAssertion(Annotation( "GOC:mah") "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.") AnnotationAssertion(rdfs:label "neuron projection morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (erythrocyte development) +AnnotationAssertion(Annotation( "GOC:devbiol") "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "erythrocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19979,6 +26401,7 @@ SubClassOf( ObjectSomeValuesFrom( (nucleate erythrocyte development) +AnnotationAssertion(Annotation( "GOC:devbiol") "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.") AnnotationAssertion(rdfs:label "nucleate erythrocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19986,6 +26409,7 @@ SubClassOf( ObjectSomeValuesFrom( (artery morphogenesis) +AnnotationAssertion(Annotation( "GOC:dsf") Annotation( "PMID:16740480") "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.") AnnotationAssertion(rdfs:label "artery morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -19993,6 +26417,7 @@ SubClassOf( ObjectSomeValuesFrom( (venous blood vessel morphogenesis) +AnnotationAssertion(Annotation( "GOC:dsf") Annotation( "PMID:16740480") "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart.") AnnotationAssertion(rdfs:label "venous blood vessel morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20000,6 +26425,7 @@ SubClassOf( ObjectSomeValuesFrom( (brain morphogenesis) +AnnotationAssertion(Annotation( "GOC:dgh") Annotation( "GOC:jid") "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).") AnnotationAssertion(rdfs:label "brain morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20007,12 +26433,14 @@ SubClassOf( ObjectSomeValuesFrom( (anatomical structure development) +AnnotationAssertion(Annotation( "GO_REF:0000021") "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.") AnnotationAssertion(rdfs:label "anatomical structure development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (neural nucleus development) +AnnotationAssertion(Annotation( "GO_REF:0000021") "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma.") AnnotationAssertion(rdfs:label "neural nucleus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20020,6 +26448,7 @@ SubClassOf( (cell projection morphogenesis) +AnnotationAssertion(Annotation( "GO_REF:0000021") "The process in which the anatomical structures of a cell projection are generated and organized.") AnnotationAssertion(rdfs:label "cell projection morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20027,6 +26456,7 @@ SubClassOf( ObjectSomeValuesFrom( (formation of anatomical boundary) +AnnotationAssertion(Annotation( "GO_REF:0000021") "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.") AnnotationAssertion(rdfs:label "formation of anatomical boundary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20034,6 +26464,8 @@ SubClassOf( (stem cell differentiation) +AnnotationAssertion(Annotation( "CL:0000034") Annotation( "GOC:isa_complete") "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.") +AnnotationAssertion( "Wikipedia:Stem_cell_differentiation") AnnotationAssertion(rdfs:label "stem cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -20042,6 +26474,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (stem cell development) +AnnotationAssertion(Annotation( "CL:0000034") Annotation( "GOC:isa_complete") "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate.") AnnotationAssertion(rdfs:label "stem cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20049,12 +26482,14 @@ SubClassOf( ObjectSomeValuesFrom( (cellular developmental process) +AnnotationAssertion(Annotation( "GOC:isa_complete") "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.") AnnotationAssertion(rdfs:label "cellular developmental process") SubClassOf( ) SubClassOf( ) # Class: (cell motility) +AnnotationAssertion(Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:isa_complete") Annotation( "GOC:mlg") "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.") AnnotationAssertion(rdfs:label "cell motility") SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -20063,29 +26498,40 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (multicellular organismal-level homeostasis) +AnnotationAssertion(Annotation( "GOC:isa_complete") "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism.") AnnotationAssertion(rdfs:label "multicellular organismal-level homeostasis") SubClassOf( ) SubClassOf( ) # Class: (homeostasis of number of cells) +AnnotationAssertion(Annotation( "GOC:isa_complete") "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.") AnnotationAssertion(rdfs:label "homeostasis of number of cells") SubClassOf( ) # Class: (homeostasis of number of cells within a tissue) +AnnotationAssertion(Annotation( "GOC:isa_complete") "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.") AnnotationAssertion(rdfs:label "homeostasis of number of cells within a tissue") SubClassOf( ) SubClassOf( ) +# Class: (chemical homeostasis) + +AnnotationAssertion(Annotation( "GOC:isa_complete") "Any biological process involved in the maintenance of an internal steady state of a chemical.") +AnnotationAssertion(rdfs:label "chemical homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (sensory system development) +AnnotationAssertion(Annotation( "GOC:dgh") "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure.") AnnotationAssertion(rdfs:label "sensory system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (peripheral nervous system neuron differentiation) +AnnotationAssertion(Annotation( "GOC:dgh") "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system.") AnnotationAssertion(rdfs:label "peripheral nervous system neuron differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20093,6 +26539,7 @@ SubClassOf( ObjectSomeValuesFrom( (peripheral nervous system neuron development) +AnnotationAssertion(Annotation( "GOC:dgh") "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.") AnnotationAssertion(rdfs:label "peripheral nervous system neuron development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20100,17 +26547,20 @@ SubClassOf( ObjectSomeValuesFrom( (chromosome localization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process in which a chromosome is transported to, or maintained in, a specific location.") AnnotationAssertion(rdfs:label "chromosome localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (catecholamine secretion) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:ef") "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.") AnnotationAssertion(rdfs:label "catecholamine secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of catecholamine secretion) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines.") AnnotationAssertion(rdfs:label "regulation of catecholamine secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20118,12 +26568,14 @@ SubClassOf( (RNA transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "RNA transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of lymphocyte proliferation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of lymphocyte proliferation.") AnnotationAssertion(rdfs:label "regulation of lymphocyte proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20131,6 +26583,7 @@ SubClassOf( (positive regulation of lymphocyte proliferation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the rate or extent of lymphocyte proliferation.") AnnotationAssertion(rdfs:label "positive regulation of lymphocyte proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20139,6 +26592,7 @@ SubClassOf( (negative regulation of lymphocyte proliferation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.") AnnotationAssertion(rdfs:label "negative regulation of lymphocyte proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20147,18 +26601,21 @@ SubClassOf( (epithelial cell proliferation) +AnnotationAssertion(Annotation( "ISBN:0721662544") "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.") AnnotationAssertion(rdfs:label "epithelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of epithelial cell proliferation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of epithelial cell proliferation.") AnnotationAssertion(rdfs:label "regulation of epithelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of epithelial cell proliferation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the rate or extent of epithelial cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of epithelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20166,6 +26623,7 @@ SubClassOf( (negative regulation of epithelial cell proliferation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of epithelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20173,6 +26631,7 @@ SubClassOf( (regulation of protein secretion) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.") AnnotationAssertion(rdfs:label "regulation of protein secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20180,6 +26639,7 @@ SubClassOf( (negative regulation of protein secretion) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.") AnnotationAssertion(rdfs:label "negative regulation of protein secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20188,6 +26648,7 @@ SubClassOf( (positive regulation of protein secretion) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.") AnnotationAssertion(rdfs:label "positive regulation of protein secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20196,6 +26657,7 @@ SubClassOf( (regulation of inflammatory response) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.") AnnotationAssertion(rdfs:label "regulation of inflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20203,6 +26665,7 @@ SubClassOf( (negative regulation of inflammatory response) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.") AnnotationAssertion(rdfs:label "negative regulation of inflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20211,6 +26674,7 @@ SubClassOf( (positive regulation of inflammatory response) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the inflammatory response.") AnnotationAssertion(rdfs:label "positive regulation of inflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20219,24 +26683,28 @@ SubClassOf( (regulation of lipoprotein metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.") AnnotationAssertion(rdfs:label "regulation of lipoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of lipoprotein metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.") AnnotationAssertion(rdfs:label "positive regulation of lipoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of lipoprotein metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.") AnnotationAssertion(rdfs:label "negative regulation of lipoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of phagocytosis) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.") AnnotationAssertion(rdfs:label "regulation of phagocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -20246,16 +26714,19 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (negative regulation of phagocytosis) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.") AnnotationAssertion(rdfs:label "negative regulation of phagocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of phagocytosis) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of phagocytosis.") AnnotationAssertion(rdfs:label "positive regulation of phagocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of neurogenesis) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.") AnnotationAssertion(rdfs:label "regulation of neurogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20264,6 +26735,7 @@ SubClassOf( ObjectSomeValuesFrom( (negative regulation of neurogenesis) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.") AnnotationAssertion(rdfs:label "negative regulation of neurogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20272,6 +26744,7 @@ SubClassOf( (positive regulation of neurogenesis) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.") AnnotationAssertion(rdfs:label "positive regulation of neurogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20280,6 +26753,7 @@ SubClassOf( (regulation of immune response) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.") AnnotationAssertion(rdfs:label "regulation of immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20287,6 +26761,7 @@ SubClassOf( (negative regulation of immune response) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.") AnnotationAssertion(rdfs:label "negative regulation of immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20295,6 +26770,7 @@ SubClassOf( (positive regulation of immune response) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.") AnnotationAssertion(rdfs:label "positive regulation of immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20303,67 +26779,114 @@ SubClassOf( (regulation of biological process) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.") AnnotationAssertion(rdfs:label "regulation of biological process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (regulation of catalytic activity) + +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:ebc") Annotation( "GOC:vw") "Any process that modulates the activity of an enzyme.") +AnnotationAssertion(rdfs:label "regulation of catalytic activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of developmental process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).") AnnotationAssertion(rdfs:label "regulation of developmental process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of cellular process) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.") AnnotationAssertion(rdfs:label "regulation of cellular process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of behavior) + +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:pr") "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.") +AnnotationAssertion(rdfs:label "regulation of behavior") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (regulation of insulin secretion) + +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the regulated release of insulin.") +AnnotationAssertion(rdfs:label "regulation of insulin secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (monoatomic ion homeostasis) + +AnnotationAssertion(Annotation( "GOC:ai") "Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.") +AnnotationAssertion(rdfs:label "monoatomic ion homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of synapse structure or activity) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).") AnnotationAssertion(rdfs:label "regulation of synapse structure or activity") SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectAllValuesFrom( )) # Class: (modulation of chemical synaptic transmission) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.") AnnotationAssertion(rdfs:label "modulation of chemical synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of synaptic transmission) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.") AnnotationAssertion(rdfs:label "negative regulation of synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of synaptic transmission) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.") AnnotationAssertion(rdfs:label "positive regulation of synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of synapse organization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).") AnnotationAssertion(rdfs:label "regulation of synapse organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (synapse organization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:pr") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).") AnnotationAssertion(rdfs:label "synapse organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (regulation of steroid biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.") +AnnotationAssertion(rdfs:label "regulation of steroid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (defense response to fungus) +AnnotationAssertion(Annotation( "GOC:ai") "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.") AnnotationAssertion(rdfs:label "defense response to fungus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of T cell activation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of T cell activation.") AnnotationAssertion(rdfs:label "regulation of T cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cell activation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.") AnnotationAssertion(rdfs:label "regulation of cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20373,6 +26896,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (negative regulation of cell activation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation.") AnnotationAssertion(rdfs:label "negative regulation of cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20380,6 +26904,7 @@ SubClassOf( (positive regulation of cell activation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of activation.") AnnotationAssertion(rdfs:label "positive regulation of cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20387,6 +26912,7 @@ SubClassOf( (negative regulation of T cell activation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.") AnnotationAssertion(rdfs:label "negative regulation of T cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20395,6 +26921,7 @@ SubClassOf( (positive regulation of T cell activation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of T cell activation.") AnnotationAssertion(rdfs:label "positive regulation of T cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20411,35 +26938,53 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (nervous system process) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mtg_cardio") "A organ system process carried out by any of the organs or tissues of neurological system.") AnnotationAssertion(rdfs:label "nervous system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectAllValuesFrom( )) +# Class: (regulation of body fluid levels) + +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the levels of body fluids.") +AnnotationAssertion(rdfs:label "regulation of body fluid levels") + # Class: (multicellular organismal movement) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_muscle") Annotation( "GOC:tb") "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism.") AnnotationAssertion(rdfs:label "multicellular organismal movement") SubClassOf( ) # Class: (musculoskeletal movement) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:dph") "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.") AnnotationAssertion(rdfs:label "musculoskeletal movement") SubClassOf( ) SubClassOf( ) # Class: (endocrine process) +AnnotationAssertion(Annotation( "ISBN:0721662544") "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.") AnnotationAssertion(rdfs:label "endocrine process") SubClassOf( ) +# Class: (cognition) + +AnnotationAssertion(Annotation( "ISBN:0721619908") "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.") +AnnotationAssertion( "Wikipedia:Cognition") +AnnotationAssertion(rdfs:label "cognition") +SubClassOf( ) + # Class: (response to stimulus) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:bf") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "response to stimulus") SubClassOf( ) # Class: (leukocyte migration) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:14680625") Annotation( "PMID:14708592") Annotation( "PMID:7507411") Annotation( "PMID:8600538") "The movement of a leukocyte within or between different tissues and organs of the body.") AnnotationAssertion(rdfs:label "leukocyte migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20449,17 +26994,21 @@ SubClassOf( ObjectAllValuesFrom( (neuromuscular process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process pertaining to the functions of the nervous and muscular systems of an organism.") AnnotationAssertion(rdfs:label "neuromuscular process") SubClassOf( ) # Class: (detection of stimulus involved in sensory perception) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dos") Annotation( "GOC:dph") "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal.") +AnnotationAssertion( "Wikipedia:Transduction_(physiology)") AnnotationAssertion(rdfs:label "detection of stimulus involved in sensory perception") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (detection of chemical stimulus involved in sensory perception) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dos") "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception.") AnnotationAssertion(rdfs:label "detection of chemical stimulus involved in sensory perception") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20468,6 +27017,7 @@ SubClassOf( ObjectSomeValuesFrom( (detection of light stimulus involved in visual perception) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dos") "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.") AnnotationAssertion(rdfs:label "detection of light stimulus involved in visual perception") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20475,24 +27025,29 @@ SubClassOf( (regulation of chemotaxis) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.") AnnotationAssertion(rdfs:label "regulation of chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of chemotaxis) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.") AnnotationAssertion(rdfs:label "positive regulation of chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of chemotaxis) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.") AnnotationAssertion(rdfs:label "negative regulation of chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (pigment cell differentiation) +AnnotationAssertion(Annotation( "GOC:dgh") "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte.") +AnnotationAssertion(rdfs:comment "Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore.") AnnotationAssertion(rdfs:label "pigment cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20500,33 +27055,39 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of pigment cell differentiation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of pigmented cell differentiation.") AnnotationAssertion(rdfs:label "regulation of pigment cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of pigment cell differentiation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of pigment cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of pigment cell differentiation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of pigment cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (sensory perception of light stimulus) +AnnotationAssertion(Annotation( "GOC:ai") "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.") AnnotationAssertion(rdfs:label "sensory perception of light stimulus") SubClassOf( ) # Class: (sensory perception of mechanical stimulus) +AnnotationAssertion(Annotation( "GOC:ai") "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.") AnnotationAssertion(rdfs:label "sensory perception of mechanical stimulus") SubClassOf( ) # Class: (detection of light stimulus involved in sensory perception) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dos") "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light.") AnnotationAssertion(rdfs:label "detection of light stimulus involved in sensory perception") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20535,34 +27096,74 @@ SubClassOf( ObjectSomeValuesFrom( (detection of chemical stimulus involved in sensory perception of pain) +AnnotationAssertion(Annotation( "GOC:ai") "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal.") AnnotationAssertion(rdfs:label "detection of chemical stimulus involved in sensory perception of pain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (sensory perception of touch) +AnnotationAssertion(Annotation( "GOC:ai") "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).") +AnnotationAssertion( "Wikipedia:Touch") AnnotationAssertion(rdfs:label "sensory perception of touch") SubClassOf( ) +# Class: (regulation of lipid catabolic process) + +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids.") +AnnotationAssertion(rdfs:label "regulation of lipid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of lipid catabolic process) + +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.") +AnnotationAssertion(rdfs:label "negative regulation of lipid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of lipid catabolic process) + +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.") +AnnotationAssertion(rdfs:label "positive regulation of lipid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (actin filament bundle assembly) +AnnotationAssertion(Annotation( "GOC:ai") "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.") AnnotationAssertion(rdfs:label "actin filament bundle assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (DNA transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "DNA transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (RNA transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:ai") "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other.") +AnnotationAssertion(Annotation(rdfs:label "Exportin complex translocates pre-miRNA to cytosol") "Reactome:R-HSA-203906") +AnnotationAssertion(rdfs:label "RNA transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (DNA transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:ai") "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other.") +AnnotationAssertion(rdfs:label "DNA transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (regulation of secretion) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.") AnnotationAssertion(rdfs:label "regulation of secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of secretion) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.") AnnotationAssertion(rdfs:label "positive regulation of secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20570,6 +27171,7 @@ SubClassOf( (negative regulation of secretion) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.") AnnotationAssertion(rdfs:label "negative regulation of secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20577,12 +27179,14 @@ SubClassOf( (regulation of transport) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "regulation of transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of transport) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "positive regulation of transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20590,6 +27194,7 @@ SubClassOf( (negative regulation of transport) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "negative regulation of transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20597,21 +27202,25 @@ SubClassOf( (regulation of DNA metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.") AnnotationAssertion(rdfs:label "regulation of DNA metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of DNA metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.") AnnotationAssertion(rdfs:label "negative regulation of DNA metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of DNA metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.") AnnotationAssertion(rdfs:label "positive regulation of DNA metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of lipid biosynthetic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.") AnnotationAssertion(rdfs:label "negative regulation of lipid biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20620,11 +27229,13 @@ SubClassOf( (meiotic nuclear membrane disassembly) +AnnotationAssertion(Annotation( "GOC:bf") "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs.") AnnotationAssertion(rdfs:label "meiotic nuclear membrane disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (nuclear membrane disassembly) +AnnotationAssertion(Annotation( "GOC:ai") "The controlled breakdown of the nuclear membranes, for example during cellular division.") AnnotationAssertion(rdfs:label "nuclear membrane disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20632,6 +27243,7 @@ SubClassOf( ObjectSomeValuesFrom( (negative regulation of developmental process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).") AnnotationAssertion(rdfs:label "negative regulation of developmental process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20639,6 +27251,7 @@ SubClassOf( (positive regulation of developmental process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).") AnnotationAssertion(rdfs:label "positive regulation of developmental process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20646,6 +27259,7 @@ SubClassOf( (regulation of cellular component organization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.") AnnotationAssertion(rdfs:label "regulation of cellular component organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20653,6 +27267,7 @@ SubClassOf( (negative regulation of cellular component organization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.") AnnotationAssertion(rdfs:label "negative regulation of cellular component organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20661,6 +27276,7 @@ SubClassOf( (positive regulation of cellular component organization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.") AnnotationAssertion(rdfs:label "positive regulation of cellular component organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20669,73 +27285,89 @@ SubClassOf( (smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:ai") "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.") AnnotationAssertion(rdfs:label "smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (striated muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000737") Annotation( "GOC:ai") "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.") AnnotationAssertion(rdfs:label "striated muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000187") Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of muscle cell differentiation.") AnnotationAssertion(rdfs:label "regulation of muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000187") Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000187") Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.") AnnotationAssertion(rdfs:label "regulation of smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000192") Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of striated muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000737") Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation.") AnnotationAssertion(rdfs:label "regulation of striated muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of striated muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000737") Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of striated muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of striated muscle cell differentiation) +AnnotationAssertion(Annotation( "CL:0000737") Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of striated muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (nuclear transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of substances into, out of, or within the nucleus.") +AnnotationAssertion( "Wikipedia:Nuclear_transport") AnnotationAssertion(rdfs:label "nuclear transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (localization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dos") "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.") AnnotationAssertion(rdfs:label "localization") SubClassOf( ) # Class: (cartilage development) +AnnotationAssertion(Annotation( "GOC:cjm") Annotation( "PMID:23251424") "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.") +AnnotationAssertion( "Wikipedia:Chondrogenesis") AnnotationAssertion(rdfs:label "cartilage development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20744,6 +27376,7 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of protein transport) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "positive regulation of protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20752,6 +27385,7 @@ SubClassOf( (regulation of protein transport) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "regulation of protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20759,6 +27393,7 @@ SubClassOf( (negative regulation of protein transport) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "negative regulation of protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20767,23 +27402,27 @@ SubClassOf( (establishment of localization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dos") "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.") AnnotationAssertion(rdfs:label "establishment of localization") SubClassOf( ) # Class: (establishment of RNA localization) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of RNA to a specific location.") AnnotationAssertion(rdfs:label "establishment of RNA localization") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of multicellular organismal process) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.") AnnotationAssertion(rdfs:label "regulation of multicellular organismal process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of multicellular organismal process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.") AnnotationAssertion(rdfs:label "positive regulation of multicellular organismal process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20792,6 +27431,7 @@ SubClassOf( ObjectSomeValuesFrom( (negative regulation of multicellular organismal process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.") AnnotationAssertion(rdfs:label "negative regulation of multicellular organismal process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20800,27 +27440,32 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of protein metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.") AnnotationAssertion(rdfs:label "regulation of protein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.") AnnotationAssertion(rdfs:label "positive regulation of protein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.") AnnotationAssertion(rdfs:label "negative regulation of protein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of lymphocyte activation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of lymphocyte activation.") AnnotationAssertion(rdfs:label "regulation of lymphocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of lymphocyte activation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.") AnnotationAssertion(rdfs:label "negative regulation of lymphocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20828,6 +27473,7 @@ SubClassOf( (positive regulation of lymphocyte activation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of lymphocyte activation.") AnnotationAssertion(rdfs:label "positive regulation of lymphocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20835,47 +27481,58 @@ SubClassOf( (regulation of RNA metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.") AnnotationAssertion(rdfs:label "regulation of RNA metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of RNA metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.") AnnotationAssertion(rdfs:label "negative regulation of RNA metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of RNA metabolic process) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.") AnnotationAssertion(rdfs:label "positive regulation of RNA metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein polymerization) +AnnotationAssertion(Annotation( "GOC:ai") "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.") AnnotationAssertion(rdfs:label "protein polymerization") SubClassOf( ) # Class: (protein depolymerization) +AnnotationAssertion(Annotation( "GOC:ai") "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.") AnnotationAssertion(rdfs:label "protein depolymerization") SubClassOf( ) # Class: (chromosome organization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.") AnnotationAssertion(rdfs:label "chromosome organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell division) +AnnotationAssertion(Annotation( "GOC:di") Annotation( "GOC:go_curators") Annotation( "GOC:pr") "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.") +AnnotationAssertion( "Wikipedia:Cell_division") +AnnotationAssertion(rdfs:comment "Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division.") AnnotationAssertion(rdfs:label "cell division") SubClassOf( ) # Class: (regulation of cell division) +AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.") AnnotationAssertion(rdfs:label "regulation of cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (establishment of chromosome localization) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of a chromosome to a specific location.") AnnotationAssertion(rdfs:label "establishment of chromosome localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20883,6 +27540,9 @@ SubClassOf( (meiotic cell cycle) +AnnotationAssertion(Annotation( "GOC:ai") "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.") +AnnotationAssertion( "Wikipedia:Meiosis") +AnnotationAssertion(rdfs:comment "Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.") AnnotationAssertion(rdfs:label "meiotic cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20890,14 +27550,42 @@ SubClassOf( ObjectSomeValuesFrom( ObjectSomeValuesFrom( )) SubClassOf( ObjectAllValuesFrom( )) +# Class: (regulation of hydrolase activity) + +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.") +AnnotationAssertion(rdfs:label "regulation of hydrolase activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of hydrolase activity) + +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.") +AnnotationAssertion(rdfs:label "positive regulation of hydrolase activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of hydrolase activity) + +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.") +AnnotationAssertion(rdfs:label "negative regulation of hydrolase activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (neuron apoptotic process) +AnnotationAssertion(Annotation( "CL:0000540") Annotation( "GOC:mtg_apoptosis") "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.") AnnotationAssertion(rdfs:label "neuron apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (detoxification of nitrogen compound) + +AnnotationAssertion(Annotation( "GOC:ai") "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.") +AnnotationAssertion(rdfs:label "detoxification of nitrogen compound") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (regulation of meiotic cell cycle) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate or extent of progression through the meiotic cell cycle.") AnnotationAssertion(rdfs:label "regulation of meiotic cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20905,6 +27593,7 @@ SubClassOf( (positive regulation of meiotic cell cycle) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.") AnnotationAssertion(rdfs:label "positive regulation of meiotic cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20913,6 +27602,7 @@ SubClassOf( (negative regulation of meiotic cell cycle) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.") AnnotationAssertion(rdfs:label "negative regulation of meiotic cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20921,18 +27611,21 @@ SubClassOf( (myoblast proliferation) +AnnotationAssertion(Annotation( "CL:0000056") Annotation( "GOC:ai") Annotation( "GOC:mtg_muscle") "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.") AnnotationAssertion(rdfs:label "myoblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myoblast migration) +AnnotationAssertion(Annotation( "CL:0000056") Annotation( "GOC:ai") Annotation( "GOC:mtg_muscle") "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.") AnnotationAssertion(rdfs:label "myoblast migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (vesicle fusion with vacuole) +AnnotationAssertion(Annotation( "GOC:ai") "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole.") AnnotationAssertion(rdfs:label "vesicle fusion with vacuole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -20940,46 +27633,55 @@ SubClassOf( (regulation of cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.") AnnotationAssertion(rdfs:label "regulation of cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.") AnnotationAssertion(rdfs:label "negative regulation of cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.") AnnotationAssertion(rdfs:label "positive regulation of cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (detection of stimulus) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:mah") "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal.") AnnotationAssertion(rdfs:label "detection of stimulus") SubClassOf( ) # Class: (norepinephrine uptake) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.") AnnotationAssertion(rdfs:label "norepinephrine uptake") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (regulation of norepinephrine uptake) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell.") AnnotationAssertion(rdfs:label "regulation of norepinephrine uptake") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of norepinephrine uptake) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell.") AnnotationAssertion(rdfs:label "negative regulation of norepinephrine uptake") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of norepinephrine uptake) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell.") AnnotationAssertion(rdfs:label "positive regulation of norepinephrine uptake") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (organelle localization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process in which an organelle is transported to, and/or maintained in, a specific location.") AnnotationAssertion(rdfs:label "organelle localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -20987,27 +27689,33 @@ SubClassOf( ObjectAllValuesFrom( (cellular localization) +AnnotationAssertion(Annotation( "GOC:tb") Annotation( "GOC:vw") "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "cellular localization") SubClassOf( ) SubClassOf( ) # Class: (Golgi localization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell.") AnnotationAssertion(rdfs:label "Golgi localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (nucleus localization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell.") AnnotationAssertion(rdfs:label "nucleus localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (vesicle localization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location.") AnnotationAssertion(rdfs:label "vesicle localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (establishment of localization in cell) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dos") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.") AnnotationAssertion(rdfs:label "establishment of localization in cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -21016,6 +27724,7 @@ SubClassOf( ObjectAllValuesFrom( (establishment of vesicle localization) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of a vesicle to a specific location.") AnnotationAssertion(rdfs:label "establishment of vesicle localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21023,24 +27732,28 @@ SubClassOf( (establishment of organelle localization) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of an organelle to a specific location.") AnnotationAssertion(rdfs:label "establishment of organelle localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (localization within membrane) +AnnotationAssertion(Annotation( "GOC:ai") "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.") AnnotationAssertion(rdfs:label "localization within membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (localization of cell) +AnnotationAssertion(Annotation( "GOC:ai") "Any process in which a cell is transported to, and/or maintained in, a specific location.") AnnotationAssertion(rdfs:label "localization of cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (establishment of Golgi localization) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of the Golgi to a specific location.") AnnotationAssertion(rdfs:label "establishment of Golgi localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21048,23 +27761,28 @@ SubClassOf( (response to other organism) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.") AnnotationAssertion(rdfs:label "response to other organism") SubClassOf( ) SubClassOf( ) # Class: (cellular response to stimulus) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:jl") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "cellular response to stimulus") SubClassOf( ) SubClassOf( ) # Class: (regulation of cell cycle) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate or extent of progression through the cell cycle.") AnnotationAssertion(rdfs:label "regulation of cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cell division) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of cell division.") AnnotationAssertion(rdfs:label "positive regulation of cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21072,6 +27790,7 @@ SubClassOf( (negative regulation of cell division) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.") AnnotationAssertion(rdfs:label "negative regulation of cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21079,17 +27798,20 @@ SubClassOf( (regulation of nuclear division) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.") AnnotationAssertion(rdfs:label "regulation of nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of nuclear division) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.") AnnotationAssertion(rdfs:label "negative regulation of nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of nuclear division) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.") AnnotationAssertion(rdfs:label "positive regulation of nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21097,27 +27819,32 @@ SubClassOf( (pigment granule localization) +AnnotationAssertion(Annotation( "GOC:ai") "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell.") AnnotationAssertion(rdfs:label "pigment granule localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of cardioblast differentiation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.") AnnotationAssertion(rdfs:label "regulation of cardioblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardioblast differentiation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.") AnnotationAssertion(rdfs:label "positive regulation of cardioblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardioblast differentiation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.") AnnotationAssertion(rdfs:label "negative regulation of cardioblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (pigment granule transport) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "pigment granule transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21125,35 +27852,41 @@ SubClassOf( (establishment of pigment granule localization) +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of a pigment granule to a specific location.") AnnotationAssertion(rdfs:label "establishment of pigment granule localization") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of sensory perception of pain) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.") AnnotationAssertion(rdfs:label "regulation of sensory perception of pain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of sensory perception) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal.") AnnotationAssertion(rdfs:label "regulation of sensory perception") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (catecholamine transport) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "ISBN:0198506732") "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.") AnnotationAssertion(rdfs:label "catecholamine transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of amine transport) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "regulation of amine transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of amine transport) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "negative regulation of amine transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21161,6 +27894,7 @@ SubClassOf( (positive regulation of amine transport) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "positive regulation of amine transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21168,6 +27902,7 @@ SubClassOf( (regulation of nervous system development) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.") AnnotationAssertion(rdfs:label "regulation of nervous system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21176,6 +27911,7 @@ SubClassOf( ObjectAllValuesFrom( (negative regulation of nervous system development) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.") AnnotationAssertion(rdfs:label "negative regulation of nervous system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21184,6 +27920,7 @@ SubClassOf( (positive regulation of nervous system development) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.") AnnotationAssertion(rdfs:label "positive regulation of nervous system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21192,17 +27929,20 @@ SubClassOf( (regulation of synapse assembly) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:pr") "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.") AnnotationAssertion(rdfs:label "regulation of synapse assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of synapse assembly) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:pr") "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.") AnnotationAssertion(rdfs:label "negative regulation of synapse assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of synapse assembly) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:pr") "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.") AnnotationAssertion(rdfs:label "positive regulation of synapse assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21210,39 +27950,46 @@ SubClassOf( (regulation of transmission of nerve impulse) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.") AnnotationAssertion(rdfs:label "regulation of transmission of nerve impulse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of transmission of nerve impulse) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.") AnnotationAssertion(rdfs:label "negative regulation of transmission of nerve impulse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of transmission of nerve impulse) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.") AnnotationAssertion(rdfs:label "positive regulation of transmission of nerve impulse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of chromosome segregation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.") AnnotationAssertion(rdfs:label "regulation of chromosome segregation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of chromosome segregation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.") AnnotationAssertion(rdfs:label "positive regulation of chromosome segregation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of chromosome segregation) +AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.") AnnotationAssertion(rdfs:label "negative regulation of chromosome segregation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (muscle cell development) +AnnotationAssertion(Annotation( "CL:0000187") Annotation( "GOC:devbiol") "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.") AnnotationAssertion(rdfs:label "muscle cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21250,6 +27997,7 @@ SubClassOf( ObjectSomeValuesFrom( (striated muscle cell development) +AnnotationAssertion(Annotation( "CL:0000737") Annotation( "GOC:devbiol") "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.") AnnotationAssertion(rdfs:label "striated muscle cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21257,6 +28005,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac myofibril assembly) +AnnotationAssertion(Annotation( "GOC:devbiol") "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.") AnnotationAssertion(rdfs:label "cardiac myofibril assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21264,6 +28013,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac cell development) +AnnotationAssertion(Annotation( "GOC:devbiol") "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual.") AnnotationAssertion(rdfs:label "cardiac cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21271,6 +28021,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:devbiol") Annotation( "GOC:mtg_heart") "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.") AnnotationAssertion(rdfs:label "cardiac muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21279,6 +28030,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac muscle tissue morphogenesis) +AnnotationAssertion(Annotation( "GOC:devbiol") "The process in which the anatomical structures of cardiac muscle tissue are generated and organized.") AnnotationAssertion(rdfs:label "cardiac muscle tissue morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21287,6 +28039,7 @@ SubClassOf( ObjectSomeValuesFrom( (atrial cardiac muscle tissue morphogenesis) +AnnotationAssertion(Annotation( "GOC:devbiol") "The process in which the anatomical structure of cardiac atrium muscle is generated and organized.") AnnotationAssertion(rdfs:label "atrial cardiac muscle tissue morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21295,6 +28048,7 @@ SubClassOf( ObjectSomeValuesFrom( (ventricular cardiac muscle tissue morphogenesis) +AnnotationAssertion(Annotation( "GOC:devbiol") "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.") AnnotationAssertion(rdfs:label "ventricular cardiac muscle tissue morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21303,6 +28057,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac muscle cell development) +AnnotationAssertion(Annotation( "GOC:devbiol") Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.") AnnotationAssertion(rdfs:label "cardiac muscle cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21310,6 +28065,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac muscle tissue growth) +AnnotationAssertion(Annotation( "GOC:devbiol") "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.") AnnotationAssertion(rdfs:label "cardiac muscle tissue growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21318,18 +28074,21 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of cardiac muscle fiber development) +AnnotationAssertion(Annotation( "GOC:vk") "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle fiber development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of cardiac muscle fiber development) +AnnotationAssertion(Annotation( "GOC:vk") "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development.") AnnotationAssertion(rdfs:label "negative regulation of cardiac muscle fiber development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of cardiac muscle fiber development) +AnnotationAssertion(Annotation( "GOC:vk") "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development.") AnnotationAssertion(rdfs:label "positive regulation of cardiac muscle fiber development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21337,74 +28096,100 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of cardiac muscle tissue growth) +AnnotationAssertion(Annotation( "GOC:vk") "Any process that modulates the frequency, rate or extent of cardiac muscle growth.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle tissue growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of cardiac muscle tissue growth) +AnnotationAssertion(Annotation( "GOC:vk") "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth.") AnnotationAssertion(rdfs:label "negative regulation of cardiac muscle tissue growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of cardiac muscle tissue growth) +AnnotationAssertion(Annotation( "GOC:vk") "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth.") AnnotationAssertion(rdfs:label "positive regulation of cardiac muscle tissue growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of cardiac muscle tissue development) +AnnotationAssertion(Annotation( "GOC:vk") "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardiac muscle tissue development) +AnnotationAssertion(Annotation( "GOC:vk") "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development.") AnnotationAssertion(rdfs:label "positive regulation of cardiac muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac muscle tissue development) +AnnotationAssertion(Annotation( "GOC:vk") "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development.") AnnotationAssertion(rdfs:label "negative regulation of cardiac muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (neuroblast division) +AnnotationAssertion(Annotation( "PMID:11163136") Annotation( "PMID:11250167") "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron.") AnnotationAssertion(rdfs:label "neuroblast division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (asymmetric neuroblast division) +AnnotationAssertion(Annotation( "GOC:dph") "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials.") AnnotationAssertion(rdfs:label "asymmetric neuroblast division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (intracellular chemical homeostasis) + +AnnotationAssertion(Annotation( "GOC:isa_complete") Annotation( "GOC:jid") "A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell.") +AnnotationAssertion(rdfs:label "intracellular chemical homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (transmembrane transport) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.") +AnnotationAssertion(rdfs:comment "Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.") AnnotationAssertion(rdfs:label "transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (lipid homeostasis) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:rl") "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.") +AnnotationAssertion(rdfs:label "lipid homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (response to lipoprotein particle) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:rl") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus.") AnnotationAssertion(rdfs:label "response to lipoprotein particle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (Golgi to secretory granule transport) +AnnotationAssertion(Annotation( "GOC:curators") "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex.") AnnotationAssertion(rdfs:label "Golgi to secretory granule transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (Golgi to transport vesicle transport) +AnnotationAssertion(Annotation( "GOC:jid") "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis.") AnnotationAssertion(rdfs:label "Golgi to transport vesicle transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of cardiac muscle contraction) +AnnotationAssertion(Annotation( "GOC:ecd") "Any process that modulates the frequency, rate or extent of cardiac muscle contraction.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21412,6 +28197,7 @@ SubClassOf( (negative regulation of cardiac muscle contraction) +AnnotationAssertion(Annotation( "GOC:ecd") "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.") AnnotationAssertion(rdfs:label "negative regulation of cardiac muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21420,12 +28206,21 @@ SubClassOf( (digestive system development) +AnnotationAssertion(Annotation( "GOC:jid") "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.") AnnotationAssertion(rdfs:label "digestive system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (roof of mouth development) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0721662544") "The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.") +AnnotationAssertion(rdfs:label "roof of mouth development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (pharyngeal system development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the structure it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.") AnnotationAssertion(rdfs:label "pharyngeal system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21433,6 +28228,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac muscle cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:rph") Annotation( "PMID:11161571") "The expansion of a cardiac muscle cell population by cell division.") AnnotationAssertion(rdfs:label "cardiac muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21440,6 +28236,7 @@ SubClassOf( ObjectSomeValuesFrom( (pericardium development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:rph") Annotation( "PMID:15138308") Annotation( "PMID:16376438") "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery.") AnnotationAssertion(rdfs:label "pericardium development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21447,6 +28244,7 @@ SubClassOf( ObjectSomeValuesFrom( (retina development in camera-type eye) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dph") Annotation( "ISBN:0815340729") "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.") AnnotationAssertion(rdfs:label "retina development in camera-type eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21454,6 +28252,7 @@ SubClassOf( ObjectSomeValuesFrom( (retina morphogenesis in camera-type eye) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dph") Annotation( "GOC:mtg_sensu") "The process in which the anatomical structure of the retina is generated and organized.") AnnotationAssertion(rdfs:label "retina morphogenesis in camera-type eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21463,12 +28262,14 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of cardiac muscle cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:rph") "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of cardiac muscle cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:rph") "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of cardiac muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21477,6 +28278,7 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of cardiac muscle cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:rph") "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of cardiac muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21485,12 +28287,14 @@ SubClassOf( ObjectSomeValuesFrom( (heart contraction) +AnnotationAssertion(Annotation( "GOC:dph") "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.") AnnotationAssertion(rdfs:label "heart contraction") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cardiac muscle contraction) +AnnotationAssertion(Annotation( "GOC:dph") "Muscle contraction of cardiac muscle tissue.") AnnotationAssertion(rdfs:label "cardiac muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21498,6 +28302,7 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic process involved in female pregnancy) +AnnotationAssertion(Annotation( "GOC:dph") "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.") AnnotationAssertion(rdfs:label "embryonic process involved in female pregnancy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21507,18 +28312,22 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of syncytium formation by plasma membrane fusion) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.") AnnotationAssertion(rdfs:label "regulation of syncytium formation by plasma membrane fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of syncytium formation by plasma membrane fusion) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.") AnnotationAssertion(rdfs:label "positive regulation of syncytium formation by plasma membrane fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (ciliary membrane) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dph") Annotation( "GOC:rph") "The portion of the plasma membrane surrounding a cilium.") +AnnotationAssertion(rdfs:comment "Note that cilia and eukaryotic flagella are deemed to be equivalent.") AnnotationAssertion(rdfs:label "ciliary membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21528,11 +28337,14 @@ SubClassOf( ObjectSomeValuesFrom( (limb development) +AnnotationAssertion(Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "PMID:11487378") "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.") +AnnotationAssertion( "Wikipedia:Limb_development") AnnotationAssertion(rdfs:label "limb development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (endocardium formation) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dph") Annotation( "PMID:17722983") "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.") AnnotationAssertion(rdfs:label "endocardium formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21541,6 +28353,7 @@ SubClassOf( ObjectSomeValuesFrom( (hematopoietic stem cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:bf") Annotation( "GOC:dph") Annotation( "GOC:rl") Annotation( "PMID:15378083") "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.") AnnotationAssertion(rdfs:label "hematopoietic stem cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21548,6 +28361,7 @@ SubClassOf( ObjectSomeValuesFrom( (camera-type eye photoreceptor cell differentiation) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye.") AnnotationAssertion(rdfs:label "camera-type eye photoreceptor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21556,12 +28370,14 @@ SubClassOf( ObjectSomeValuesFrom( (retinal rod cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell.") AnnotationAssertion(rdfs:label "retinal rod cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (mesenchymal to epithelial transition) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell.") AnnotationAssertion(rdfs:label "mesenchymal to epithelial transition") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21569,34 +28385,41 @@ SubClassOf( ObjectSomeValuesFrom( (anatomical structure homeostasis) +AnnotationAssertion(Annotation( "GOC:dph") "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.") AnnotationAssertion(rdfs:label "anatomical structure homeostasis") SubClassOf( ) # Class: (regulation of glial cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of glial cell proliferation.") AnnotationAssertion(rdfs:label "regulation of glial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of glial cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sl") Annotation( "GOC:tb") "Any process that activates or increases the rate or extent of glial cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of glial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of glial cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sl") Annotation( "GOC:tb") "Any process that stops or decreases the rate or extent of glial cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of glial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of macromolecule metabolic process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.") AnnotationAssertion(rdfs:label "regulation of macromolecule metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cilium assembly) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:cilia") Annotation( "GOC:dph") Annotation( "GOC:kmv") Annotation( "GOC:pr") Annotation( "GOC:vw") Annotation( "ISBN:0198506732") Annotation( "PMID:13978319") Annotation( "PMID:27350441") "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.") +AnnotationAssertion(rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent.") AnnotationAssertion(rdfs:label "cilium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -21628,52 +28451,62 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (regulation of oocyte development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") Annotation( "PMID:2394318") "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.") AnnotationAssertion(rdfs:label "regulation of oocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of oocyte development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.") AnnotationAssertion(rdfs:label "positive regulation of oocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of oocyte development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.") AnnotationAssertion(rdfs:label "negative regulation of oocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cell development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.") AnnotationAssertion(rdfs:label "regulation of cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cilium-dependent cell motility) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:krc") Annotation( "GOC:mlg") Annotation( "GOC:mtg_cambridge_2013") "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.") +AnnotationAssertion(rdfs:comment "Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent.") AnnotationAssertion(rdfs:label "cilium-dependent cell motility") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cilium movement involved in cell motility) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Movement of cilia mediated by motor proteins that contributes to the movement of a cell.") AnnotationAssertion(rdfs:label "cilium movement involved in cell motility") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of cilium movement involved in cell motility) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility.") AnnotationAssertion(rdfs:label "regulation of cilium movement involved in cell motility") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of sarcomere organization) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.") AnnotationAssertion(rdfs:label "regulation of sarcomere organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of sarcomere organization) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.") AnnotationAssertion(rdfs:label "positive regulation of sarcomere organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -21681,6 +28514,7 @@ SubClassOf( ObjectSomeValuesFrom( (negative regulation of sarcomere organization) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.") AnnotationAssertion(rdfs:label "negative regulation of sarcomere organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -21689,6 +28523,7 @@ SubClassOf( ObjectSomeValuesFrom( (head development) +AnnotationAssertion(Annotation( "GOC:dph") "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.") AnnotationAssertion(rdfs:label "head development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21696,6 +28531,7 @@ SubClassOf( (head morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body.") AnnotationAssertion(rdfs:label "head morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21705,6 +28541,7 @@ SubClassOf( ObjectSomeValuesFrom( (face development) +AnnotationAssertion(Annotation( "GOC:dph") "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.") AnnotationAssertion(rdfs:label "face development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21713,6 +28550,7 @@ SubClassOf( ObjectSomeValuesFrom( (face morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head.") AnnotationAssertion(rdfs:label "face morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21722,6 +28560,7 @@ SubClassOf( ObjectSomeValuesFrom( (cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:dph") "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).") AnnotationAssertion(rdfs:label "cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21730,11 +28569,48 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of cellular localization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.") AnnotationAssertion(rdfs:label "regulation of cellular localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (trabecula formation) + +AnnotationAssertion(Annotation( "GOC:dph") "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.") +AnnotationAssertion(rdfs:label "trabecula formation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (liver trabecula formation) + +AnnotationAssertion(Annotation( "GOC:dph") "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod.") +AnnotationAssertion(rdfs:label "liver trabecula formation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (spleen trabecula formation) + +AnnotationAssertion(Annotation( "GOC:dph") "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod.") +AnnotationAssertion(rdfs:label "spleen trabecula formation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (heart trabecula formation) + +AnnotationAssertion(Annotation( "GOC:dph") "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.") +AnnotationAssertion(rdfs:label "heart trabecula formation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (bone development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.") AnnotationAssertion(rdfs:label "bone development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21742,6 +28618,7 @@ SubClassOf( ObjectSomeValuesFrom( (bone morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which bones are generated and organized.") AnnotationAssertion(rdfs:label "bone morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21752,11 +28629,13 @@ SubClassOf( ObjectSomeValuesFrom( (endochondral bone morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:11680679") "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone.") AnnotationAssertion(rdfs:label "endochondral bone morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cartilage development involved in endochondral bone morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.") AnnotationAssertion(rdfs:label "cartilage development involved in endochondral bone morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21764,17 +28643,20 @@ SubClassOf( (response to ammonium ion) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000071") Annotation( "PMID:23509267") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.") AnnotationAssertion(rdfs:label "response to ammonium ion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cardiac muscle cell myoblast differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.") AnnotationAssertion(rdfs:label "cardiac muscle cell myoblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (axonemal microtubule depolymerization) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dph") Annotation( "GOC:krc") Annotation( "GOC:tb") "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules.") AnnotationAssertion(rdfs:label "axonemal microtubule depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21782,6 +28664,7 @@ SubClassOf( (cardiac septum morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.") AnnotationAssertion(rdfs:label "cardiac septum morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21791,6 +28674,7 @@ SubClassOf( ObjectSomeValuesFrom( (ventricular septum morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.") AnnotationAssertion(rdfs:label "ventricular septum morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21798,6 +28682,7 @@ SubClassOf( ObjectSomeValuesFrom( (atrial septum morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another.") AnnotationAssertion(rdfs:label "atrial septum morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21806,6 +28691,7 @@ SubClassOf( ObjectSomeValuesFrom( (aorta smooth muscle tissue morphogenesis) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "Wikipedia:Aorta") "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.") AnnotationAssertion(rdfs:label "aorta smooth muscle tissue morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21814,6 +28700,7 @@ SubClassOf( ObjectSomeValuesFrom( (muscle tissue morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function.") AnnotationAssertion(rdfs:label "muscle tissue morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21821,12 +28708,14 @@ SubClassOf( ObjectSomeValuesFrom( (heart growth) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The increase in size or mass of the heart.") AnnotationAssertion(rdfs:label "heart growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of heart growth) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.") AnnotationAssertion(rdfs:label "regulation of heart growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21834,12 +28723,14 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of heart growth) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.") AnnotationAssertion(rdfs:label "positive regulation of heart growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lung morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structures of the lung are generated and organized.") AnnotationAssertion(rdfs:label "lung morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21847,6 +28738,7 @@ SubClassOf( ObjectSomeValuesFrom( (lung vasculature development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs.") AnnotationAssertion(rdfs:label "lung vasculature development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21854,6 +28746,7 @@ SubClassOf( ObjectSomeValuesFrom( (lung connective tissue development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs.") AnnotationAssertion(rdfs:label "lung connective tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21861,6 +28754,7 @@ SubClassOf( ObjectSomeValuesFrom( (lung epithelium development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung.") AnnotationAssertion(rdfs:label "lung epithelium development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21868,12 +28762,14 @@ SubClassOf( ObjectSomeValuesFrom( (epithelium development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.") AnnotationAssertion(rdfs:label "epithelium development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (primary lung bud formation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds.") AnnotationAssertion(rdfs:label "primary lung bud formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21883,6 +28779,7 @@ SubClassOf( (bronchus development) +AnnotationAssertion(Annotation( "GOC:dph") "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs.") AnnotationAssertion(rdfs:label "bronchus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21891,6 +28788,7 @@ SubClassOf( ObjectSomeValuesFrom( (bronchus morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs.") AnnotationAssertion(rdfs:label "bronchus morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21898,6 +28796,7 @@ SubClassOf( ObjectSomeValuesFrom( (bronchiole development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi.") AnnotationAssertion(rdfs:label "bronchiole development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21906,6 +28805,7 @@ SubClassOf( ObjectSomeValuesFrom( (bronchiole morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi.") AnnotationAssertion(rdfs:label "bronchiole morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21914,6 +28814,7 @@ SubClassOf( ObjectSomeValuesFrom( (lung growth) +AnnotationAssertion(Annotation( "GOC:dph") "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.") AnnotationAssertion(rdfs:label "lung growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21921,6 +28822,7 @@ SubClassOf( ObjectSomeValuesFrom( (trachea development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.") AnnotationAssertion(rdfs:label "trachea development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21929,6 +28831,7 @@ SubClassOf( ObjectSomeValuesFrom( (trachea morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches.") AnnotationAssertion(rdfs:label "trachea morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21936,6 +28839,7 @@ SubClassOf( ObjectSomeValuesFrom( (trachea formation) +AnnotationAssertion(Annotation( "GOC:dph") "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches.") AnnotationAssertion(rdfs:label "trachea formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21943,11 +28847,25 @@ SubClassOf( ObjectSomeValuesFrom( (epithelial tube branching involved in lung morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.") AnnotationAssertion(rdfs:label "epithelial tube branching involved in lung morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (positive regulation of hindgut contraction) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.") +AnnotationAssertion(rdfs:label "positive regulation of hindgut contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of hindgut contraction) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.") +AnnotationAssertion(rdfs:label "negative regulation of hindgut contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (positive regulation of cardiac muscle contraction) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of cardiac muscle contraction.") AnnotationAssertion(rdfs:label "positive regulation of cardiac muscle contraction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21956,6 +28874,7 @@ SubClassOf( (regulation of gastric acid secretion) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.") AnnotationAssertion(rdfs:label "regulation of gastric acid secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21963,6 +28882,7 @@ SubClassOf( (positive regulation of gastric acid secretion) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.") AnnotationAssertion(rdfs:label "positive regulation of gastric acid secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21971,6 +28891,7 @@ SubClassOf( (negative regulation of gastric acid secretion) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.") AnnotationAssertion(rdfs:label "negative regulation of gastric acid secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21979,6 +28900,7 @@ SubClassOf( (positive regulation of digestive system process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.") AnnotationAssertion(rdfs:label "positive regulation of digestive system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21986,6 +28908,7 @@ SubClassOf( (negative regulation of digestive system process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.") AnnotationAssertion(rdfs:label "negative regulation of digestive system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -21993,18 +28916,21 @@ SubClassOf( (right lung development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect.") AnnotationAssertion(rdfs:label "right lung development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (left lung development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect.") AnnotationAssertion(rdfs:label "left lung development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (left lung morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which anatomical structures of the left lung are generated and organized.") AnnotationAssertion(rdfs:label "left lung morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22012,6 +28938,7 @@ SubClassOf( ObjectSomeValuesFrom( (right lung morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The process in which anatomical structures of the right lung are generated and organized.") AnnotationAssertion(rdfs:label "right lung morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22019,6 +28946,7 @@ SubClassOf( ObjectSomeValuesFrom( (lung lobe development) +AnnotationAssertion(Annotation( "GOC:dph") "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung.") AnnotationAssertion(rdfs:label "lung lobe development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22027,6 +28955,7 @@ SubClassOf( ObjectSomeValuesFrom( (lung lobe morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.") AnnotationAssertion(rdfs:label "lung lobe morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22036,6 +28965,7 @@ SubClassOf( ObjectSomeValuesFrom( (lung lobe formation) +AnnotationAssertion(Annotation( "GOC:dph") "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung.") AnnotationAssertion(rdfs:label "lung lobe formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22044,28 +28974,33 @@ SubClassOf( ObjectSomeValuesFrom( (pharynx development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:rk") "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.") AnnotationAssertion(rdfs:label "pharynx development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of fertilization) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).") AnnotationAssertion(rdfs:label "negative regulation of fertilization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (prevention of polyspermy) +AnnotationAssertion(Annotation( "GOC:dph") "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg.") AnnotationAssertion(rdfs:label "prevention of polyspermy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (lung cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate.") AnnotationAssertion(rdfs:label "lung cell differentiation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (mesenchyme development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.") AnnotationAssertion(rdfs:label "mesenchyme development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22073,12 +29008,14 @@ SubClassOf( ObjectSomeValuesFrom( (club cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") Annotation( "PMID:28144783") "The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles.") AnnotationAssertion(rdfs:label "club cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lung epithelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.") AnnotationAssertion(rdfs:label "lung epithelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22087,50 +29024,59 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of cell projection assembly) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency, or extent of cell projection assembly.") AnnotationAssertion(rdfs:label "regulation of cell projection assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cell-cell signaling involved in lung development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure.") AnnotationAssertion(rdfs:label "cell-cell signaling involved in lung development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mesenchymal-epithelial cell signaling involved in lung development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung.") AnnotationAssertion(rdfs:label "mesenchymal-epithelial cell signaling involved in lung development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mesenchymal-endodermal cell signaling) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell.") AnnotationAssertion(rdfs:label "mesenchymal-endodermal cell signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (positive regulation of epithelial cell proliferation involved in lung morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.") AnnotationAssertion(rdfs:label "positive regulation of epithelial cell proliferation involved in lung morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (epithelial cell proliferation involved in lung morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung.") AnnotationAssertion(rdfs:label "epithelial cell proliferation involved in lung morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (type I pneumocyte differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") Annotation( "ISBN:0721662544") "The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.") AnnotationAssertion(rdfs:label "type I pneumocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (type II pneumocyte differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") Annotation( "ISBN:0721662544") "The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies.") AnnotationAssertion(rdfs:label "type II pneumocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (bronchus cartilage development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.") AnnotationAssertion(rdfs:label "bronchus cartilage development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22138,6 +29084,7 @@ SubClassOf( ObjectSomeValuesFrom( (bronchus cartilage morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs.") AnnotationAssertion(rdfs:label "bronchus cartilage morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22146,6 +29093,7 @@ SubClassOf( ObjectSomeValuesFrom( (trachea cartilage development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.") AnnotationAssertion(rdfs:label "trachea cartilage development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22153,6 +29101,7 @@ SubClassOf( ObjectSomeValuesFrom( (trachea cartilage morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structures of cartilage in the trachea are generated and organized.") AnnotationAssertion(rdfs:label "trachea cartilage morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22161,6 +29110,7 @@ SubClassOf( ObjectSomeValuesFrom( (cartilage morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structures of cartilage are generated and organized.") AnnotationAssertion(rdfs:label "cartilage morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22168,18 +29118,21 @@ SubClassOf( ObjectSomeValuesFrom( (muscle tissue development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.") AnnotationAssertion(rdfs:label "muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (skeletal muscle organ development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.") AnnotationAssertion(rdfs:label "skeletal muscle organ development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (diaphragm development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs.") AnnotationAssertion(rdfs:label "diaphragm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22190,6 +29143,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (diaphragm morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structures of the diaphragm are generated and organized.") AnnotationAssertion(rdfs:label "diaphragm morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22200,24 +29154,28 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (respiratory system development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.") AnnotationAssertion(rdfs:label "respiratory system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (developmental growth involved in morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.") AnnotationAssertion(rdfs:label "developmental growth involved in morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (apoptotic process involved in morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") "Any apoptotic process that contributes to the shaping of an anatomical structure.") AnnotationAssertion(rdfs:label "apoptotic process involved in morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (epithelial tube morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.") AnnotationAssertion(rdfs:label "epithelial tube morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22225,40 +29183,71 @@ SubClassOf( (neuroepithelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The process in which epiblast cells acquire specialized features of neuroepithelial cells.") AnnotationAssertion(rdfs:label "neuroepithelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (morphogenesis of an epithelial fold) +AnnotationAssertion(Annotation( "GOC:dph") "The morphogenetic process in which an epithelial sheet bends along a linear axis.") AnnotationAssertion(rdfs:label "morphogenesis of an epithelial fold") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (morphogenesis of an epithelial bud) +AnnotationAssertion(Annotation( "GOC:dph") "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding.") AnnotationAssertion(rdfs:label "morphogenesis of an epithelial bud") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (intestinal epithelial cell maturation) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:18824147") "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus.") +AnnotationAssertion(rdfs:label "intestinal epithelial cell maturation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (intestinal epithelial cell differentiation) + +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine.") +AnnotationAssertion(rdfs:label "intestinal epithelial cell differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (intestinal epithelial cell development) + +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure.") +AnnotationAssertion(rdfs:label "intestinal epithelial cell development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (pulmonary vein morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart.") AnnotationAssertion(rdfs:label "pulmonary vein morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (superior vena cava morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart.") AnnotationAssertion(rdfs:label "superior vena cava morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cell fate commitment involved in pattern specification) +AnnotationAssertion(Annotation( "GOC:dph") "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type.") AnnotationAssertion(rdfs:label "cell fate commitment involved in pattern specification") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (chondroblast differentiation) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.") AnnotationAssertion(rdfs:label "chondroblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22266,6 +29255,7 @@ SubClassOf( ObjectSomeValuesFrom( (adipose tissue development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.") AnnotationAssertion(rdfs:label "adipose tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22273,11 +29263,13 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of chromosome condensation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.") AnnotationAssertion(rdfs:label "regulation of chromosome condensation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of vesicle-mediated transport) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.") AnnotationAssertion(rdfs:label "regulation of vesicle-mediated transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22285,21 +29277,25 @@ SubClassOf( (regulation of microtubule-based movement) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.") AnnotationAssertion(rdfs:label "regulation of microtubule-based movement") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mesenchymal-epithelial cell signaling) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted.") AnnotationAssertion(rdfs:label "mesenchymal-epithelial cell signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (epithelial-mesenchymal cell signaling) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted.") AnnotationAssertion(rdfs:label "epithelial-mesenchymal cell signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (regulation of morphogenesis of a branching structure) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized.") AnnotationAssertion(rdfs:label "regulation of morphogenesis of a branching structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22307,24 +29303,28 @@ SubClassOf( (regulation of cell proliferation involved in tissue homeostasis) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue.") AnnotationAssertion(rdfs:label "regulation of cell proliferation involved in tissue homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of apoptosis involved in tissue homeostasis) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue.") AnnotationAssertion(rdfs:label "regulation of apoptosis involved in tissue homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of cell differentiation involved in tissue homeostasis) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue.") AnnotationAssertion(rdfs:label "regulation of cell differentiation involved in tissue homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (ectodermal placode formation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.") AnnotationAssertion(rdfs:label "ectodermal placode formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22333,11 +29333,13 @@ SubClassOf( ObjectSomeValuesFrom( (cell fate commitment involved in formation of primary germ layer) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.") AnnotationAssertion(rdfs:label "cell fate commitment involved in formation of primary germ layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (blood vessel endothelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels.") AnnotationAssertion(rdfs:label "blood vessel endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22345,41 +29347,48 @@ SubClassOf( ObjectSomeValuesFrom( (artery development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.") AnnotationAssertion(rdfs:label "artery development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (venous blood vessel development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed.") AnnotationAssertion(rdfs:label "venous blood vessel development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (arterial endothelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries.") AnnotationAssertion(rdfs:label "arterial endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (venous endothelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins.") AnnotationAssertion(rdfs:label "venous endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (neural plate pattern specification) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate.") AnnotationAssertion(rdfs:label "neural plate pattern specification") SubClassOf( ) # Class: (neural plate regionalization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.") AnnotationAssertion(rdfs:label "neural plate regionalization") SubClassOf( ) SubClassOf( ) # Class: (embryonic camera-type eye formation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape.") AnnotationAssertion(rdfs:label "embryonic camera-type eye formation") SubClassOf( ) SubClassOf( ) @@ -22387,11 +29396,13 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of macrophage cytokine production) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") AnnotationAssertion(rdfs:label "positive regulation of macrophage cytokine production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (heart formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.") AnnotationAssertion(rdfs:label "heart formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22399,22 +29410,26 @@ SubClassOf( ObjectSomeValuesFrom( (mesenchymal cell differentiation involved in lung development) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.") AnnotationAssertion(rdfs:label "mesenchymal cell differentiation involved in lung development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mesenchymal cell proliferation involved in lung development) +AnnotationAssertion(Annotation( "GOC:dph") "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.") AnnotationAssertion(rdfs:label "mesenchymal cell proliferation involved in lung development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cardiac pacemaker cell differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:mtg_heart") "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.") AnnotationAssertion(rdfs:label "cardiac pacemaker cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (sinoatrial node cell differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node.") AnnotationAssertion(rdfs:label "sinoatrial node cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22422,6 +29437,7 @@ SubClassOf( ObjectSomeValuesFrom( (atrioventricular node cell differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node.") AnnotationAssertion(rdfs:label "atrioventricular node cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22429,6 +29445,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac pacemaker cell development) +AnnotationAssertion(Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.") AnnotationAssertion(rdfs:label "cardiac pacemaker cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22436,6 +29453,7 @@ SubClassOf( ObjectSomeValuesFrom( (atrioventricular node cell development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state.") AnnotationAssertion(rdfs:label "atrioventricular node cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22443,6 +29461,7 @@ SubClassOf( ObjectSomeValuesFrom( (sinoatrial node cell development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node.") AnnotationAssertion(rdfs:label "sinoatrial node cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22450,6 +29469,7 @@ SubClassOf( ObjectSomeValuesFrom( (His-Purkinje system cell differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles.") AnnotationAssertion(rdfs:label "His-Purkinje system cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22457,6 +29477,7 @@ SubClassOf( ObjectSomeValuesFrom( (His-Purkinje system cell development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles.") AnnotationAssertion(rdfs:label "His-Purkinje system cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22464,12 +29485,14 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac fibroblast cell differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules.") AnnotationAssertion(rdfs:label "cardiac fibroblast cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cardiac fibroblast cell development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules.") AnnotationAssertion(rdfs:label "cardiac fibroblast cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22477,6 +29500,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac neuron differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart.") AnnotationAssertion(rdfs:label "cardiac neuron differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22485,6 +29509,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac blood vessel endothelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels.") AnnotationAssertion(rdfs:label "cardiac blood vessel endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22492,6 +29517,7 @@ SubClassOf( (cardiac glial cell differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart.") AnnotationAssertion(rdfs:label "cardiac glial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22499,6 +29525,7 @@ SubClassOf( (cardiac glial cell development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell.") AnnotationAssertion(rdfs:label "cardiac glial cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22507,6 +29534,7 @@ SubClassOf( ObjectSomeValuesFrom( (endocardial cell differentiation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers.") AnnotationAssertion(rdfs:label "endocardial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22515,6 +29543,7 @@ SubClassOf( ObjectSomeValuesFrom( (endocardial cell development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart.") AnnotationAssertion(rdfs:label "endocardial cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22522,6 +29551,7 @@ SubClassOf( ObjectSomeValuesFrom( (cardiac neuron development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state.") AnnotationAssertion(rdfs:label "cardiac neuron development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22530,16 +29560,19 @@ SubClassOf( ObjectSomeValuesFrom( (cell migration involved in heart development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ.") AnnotationAssertion(rdfs:label "cell migration involved in heart development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell migration involved in heart formation) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells.") AnnotationAssertion(rdfs:label "cell migration involved in heart formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (coronary vasculature development) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "coronary vasculature development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22547,6 +29580,7 @@ SubClassOf( ObjectSomeValuesFrom( (coronary vasculature morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood.") AnnotationAssertion(rdfs:label "coronary vasculature morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22554,45 +29588,103 @@ SubClassOf( ObjectSomeValuesFrom( (angiogenesis involved in coronary vascular morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels.") AnnotationAssertion(rdfs:label "angiogenesis involved in coronary vascular morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vasculogenesis involved in coronary vascular morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes.") AnnotationAssertion(rdfs:label "vasculogenesis involved in coronary vascular morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell migration involved in coronary vasculogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart.") AnnotationAssertion(rdfs:label "cell migration involved in coronary vasculogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell migration involved in coronary angiogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_heart") "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels.") AnnotationAssertion(rdfs:label "cell migration involved in coronary angiogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (endocrine hormone secretion) +AnnotationAssertion(Annotation( "GOC:dph") "The regulated release of a hormone into the circulatory system.") AnnotationAssertion(rdfs:label "endocrine hormone secretion") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepaticobiliary system process) + +AnnotationAssertion(Annotation( "GOC:dph") "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.") +AnnotationAssertion(rdfs:label "hepaticobiliary system process") +SubClassOf( ) + +# Class: (hepaticobiliary system development) + +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.") +AnnotationAssertion(rdfs:label "hepaticobiliary system development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (common bile duct development) + +AnnotationAssertion(Annotation( "PMID:20614624") "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine.") +AnnotationAssertion(rdfs:label "common bile duct development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (gallbladder development) + +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile.") +AnnotationAssertion(rdfs:label "gallbladder development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (hepatic duct development) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:20614624") "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct.") +AnnotationAssertion(rdfs:label "hepatic duct development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (hepatoblast differentiation) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:15226394") "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes.") +AnnotationAssertion(rdfs:label "hepatoblast differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (membrane organization) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.") AnnotationAssertion(rdfs:label "membrane organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (membrane fusion) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The membrane organization process that joins two lipid bilayers to form a single membrane.") +AnnotationAssertion( "Wikipedia:Lipid_bilayer_fusion") AnnotationAssertion(rdfs:label "membrane fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (visceral serous pericardium development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.") AnnotationAssertion(rdfs:label "visceral serous pericardium development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22600,12 +29692,14 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of cartilage development) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.") AnnotationAssertion(rdfs:label "regulation of cartilage development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of cartilage development) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.") AnnotationAssertion(rdfs:label "positive regulation of cartilage development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22614,6 +29708,7 @@ SubClassOf( (negative regulation of cartilage development) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.") AnnotationAssertion(rdfs:label "negative regulation of cartilage development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22622,6 +29717,7 @@ SubClassOf( (female gonad morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "The process in which a female gonad is generated and organized.") AnnotationAssertion(rdfs:label "female gonad morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22629,21 +29725,25 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of branching involved in lung morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.") AnnotationAssertion(rdfs:label "regulation of branching involved in lung morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of branching involved in lung morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.") AnnotationAssertion(rdfs:label "positive regulation of branching involved in lung morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of branching involved in lung morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.") AnnotationAssertion(rdfs:label "negative regulation of branching involved in lung morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell growth involved in cardiac muscle cell development) +AnnotationAssertion(Annotation( "GOC:dph") "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.") AnnotationAssertion(rdfs:label "cell growth involved in cardiac muscle cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22652,12 +29752,14 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of cell growth involved in cardiac muscle cell development) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.") AnnotationAssertion(rdfs:label "regulation of cell growth involved in cardiac muscle cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of cell growth involved in cardiac muscle cell development) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.") AnnotationAssertion(rdfs:label "positive regulation of cell growth involved in cardiac muscle cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22666,6 +29768,7 @@ SubClassOf( (negative regulation of cell growth involved in cardiac muscle cell development) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.") AnnotationAssertion(rdfs:label "negative regulation of cell growth involved in cardiac muscle cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22674,6 +29777,7 @@ SubClassOf( (somite development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.") AnnotationAssertion(rdfs:label "somite development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22681,6 +29785,7 @@ SubClassOf( ObjectSomeValuesFrom( (dermatome development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.") AnnotationAssertion(rdfs:label "dermatome development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22689,6 +29794,7 @@ SubClassOf( ObjectSomeValuesFrom( (myotome development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle.") AnnotationAssertion(rdfs:label "myotome development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22697,6 +29803,7 @@ SubClassOf( ObjectSomeValuesFrom( (sclerotome development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.") AnnotationAssertion(rdfs:label "sclerotome development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22704,6 +29811,7 @@ SubClassOf( ObjectSomeValuesFrom( (muscle structure development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.") AnnotationAssertion(rdfs:label "muscle structure development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22713,6 +29821,7 @@ SubClassOf( ObjectAllValuesFrom( (iris morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina.") AnnotationAssertion(rdfs:label "iris morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22721,6 +29830,7 @@ SubClassOf( ObjectSomeValuesFrom( (ciliary body morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes.") AnnotationAssertion(rdfs:label "ciliary body morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22729,23 +29839,27 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of neural retina development) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.") AnnotationAssertion(rdfs:label "regulation of neural retina development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of neural retina development) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.") AnnotationAssertion(rdfs:label "positive regulation of neural retina development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of neural retina development) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.") AnnotationAssertion(rdfs:label "negative regulation of neural retina development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (right horn of sinus venosus development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the right horn of the sinus venosus from its formation to the mature structure.") AnnotationAssertion(rdfs:label "right horn of sinus venosus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22753,16 +29867,20 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of myeloid leukocyte cytokine production involved in immune response) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response.") AnnotationAssertion(rdfs:label "positive regulation of myeloid leukocyte cytokine production involved in immune response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (myeloid leukocyte cytokine production) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that contributes to cytokine production by a myeloid cell.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.") AnnotationAssertion(rdfs:label "myeloid leukocyte cytokine production") SubClassOf( ) # Class: (lung neuroendocrine cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:9126746") "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium.") AnnotationAssertion(rdfs:label "lung neuroendocrine cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22770,11 +29888,13 @@ SubClassOf( (neuroendocrine cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.") AnnotationAssertion(rdfs:label "neuroendocrine cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (stomach neuroendocrine cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:18173746") "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium.") AnnotationAssertion(rdfs:label "stomach neuroendocrine cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22782,51 +29902,82 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of stomach neuroendocrine cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.") AnnotationAssertion(rdfs:label "regulation of stomach neuroendocrine cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of stomach neuroendocrine cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.") AnnotationAssertion(rdfs:label "negative regulation of stomach neuroendocrine cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (dense core granule organization) +AnnotationAssertion(Annotation( "GOC:dph") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells.") AnnotationAssertion(rdfs:label "dense core granule organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (epithelial-mesenchymal cell signaling involved in lung development) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ.") AnnotationAssertion(rdfs:label "epithelial-mesenchymal cell signaling involved in lung development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (pancreas morphogenesis) + +AnnotationAssertion(Annotation( "GOC:dph") "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized.") +AnnotationAssertion(rdfs:label "pancreas morphogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (branching involved in pancreas morphogenesis) + +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the branches of the pancreas are generated and organized.") +AnnotationAssertion(rdfs:label "branching involved in pancreas morphogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (negative regulation of heart growth) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:hjd") "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.") AnnotationAssertion(rdfs:label "negative regulation of heart growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (pancreatic bud formation) + +AnnotationAssertion(Annotation( "GOC:dph") "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud.") +AnnotationAssertion(rdfs:label "pancreatic bud formation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (morphogenesis of a branching epithelium) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structures of a branched epithelium are generated and organized.") AnnotationAssertion(rdfs:label "morphogenesis of a branching epithelium") SubClassOf( ) SubClassOf( ) # Class: (lung secretory cell differentiation) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part.") AnnotationAssertion(rdfs:label "lung secretory cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lung ciliated cell differentiation) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dph") Annotation( "GOC:krc") "The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells.") AnnotationAssertion(rdfs:label "lung ciliated cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (endocardial endothelium development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.") AnnotationAssertion(rdfs:label "endocardial endothelium development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22834,18 +29985,29 @@ SubClassOf( ObjectSomeValuesFrom( (extracellular matrix organization involved in endocardium development) +AnnotationAssertion(Annotation( "GOC:dph") "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.") AnnotationAssertion(rdfs:label "extracellular matrix organization involved in endocardium development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (trachea submucosa development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea.") AnnotationAssertion(rdfs:label "trachea submucosa development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (trachea gland development) + +AnnotationAssertion(Annotation( "GOC:dph") "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection.") +AnnotationAssertion(rdfs:label "trachea gland development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (endothelial tube morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.") AnnotationAssertion(rdfs:label "endothelial tube morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22853,6 +30015,7 @@ SubClassOf( (pulmonary artery endothelial tube morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery.") AnnotationAssertion(rdfs:label "pulmonary artery endothelial tube morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22860,12 +30023,28 @@ SubClassOf( ObjectSomeValuesFrom( (pulmonary artery morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.") AnnotationAssertion(rdfs:label "pulmonary artery morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (regulation of insulin secretion involved in cellular response to glucose stimulus) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.") +AnnotationAssertion(rdfs:label "regulation of insulin secretion involved in cellular response to glucose stimulus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (negative regulation of insulin secretion involved in cellular response to glucose stimulus) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.") +AnnotationAssertion(rdfs:label "negative regulation of insulin secretion involved in cellular response to glucose stimulus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (regulation of chondrocyte development) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.") AnnotationAssertion(rdfs:label "regulation of chondrocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22873,6 +30052,7 @@ SubClassOf( (negative regulation of chondrocyte development) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.") AnnotationAssertion(rdfs:label "negative regulation of chondrocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22881,33 +30061,39 @@ SubClassOf( (regulation of dermatome development) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.") AnnotationAssertion(rdfs:label "regulation of dermatome development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of dermatome development) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.") AnnotationAssertion(rdfs:label "positive regulation of dermatome development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of dermatome development) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.") AnnotationAssertion(rdfs:label "negative regulation of dermatome development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of sclerotome development) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.") AnnotationAssertion(rdfs:label "positive regulation of sclerotome development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of sclerotome development) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.") AnnotationAssertion(rdfs:label "regulation of sclerotome development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (retina vasculature development in camera-type eye) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "retina vasculature development in camera-type eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22915,6 +30101,7 @@ SubClassOf( ObjectSomeValuesFrom( (retina vasculature morphogenesis in camera-type eye) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "The process in which the vasculature of the retina is generated and organized.") AnnotationAssertion(rdfs:label "retina vasculature morphogenesis in camera-type eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22923,6 +30110,7 @@ SubClassOf( ObjectSomeValuesFrom( (cornea development in camera-type eye) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye.") AnnotationAssertion(rdfs:label "cornea development in camera-type eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22931,6 +30119,7 @@ SubClassOf( ObjectSomeValuesFrom( (retinal blood vessel morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "retinal blood vessel morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -22938,88 +30127,132 @@ SubClassOf( (cardiac neural crest cell differentiation involved in heart development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") Annotation( "PMID:19705442") "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches.") AnnotationAssertion(rdfs:label "cardiac neural crest cell differentiation involved in heart development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cardiac neural crest cell development involved in heart development) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart.") AnnotationAssertion(rdfs:label "cardiac neural crest cell development involved in heart development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cardiac neural crest cell development involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract.") AnnotationAssertion(rdfs:label "cardiac neural crest cell development involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell proliferation involved in heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart.") AnnotationAssertion(rdfs:label "cell proliferation involved in heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell proliferation involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract.") AnnotationAssertion(rdfs:label "cell proliferation involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cardiac conduction) +AnnotationAssertion(Annotation( "GOC:dph") "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.") AnnotationAssertion(rdfs:label "cardiac conduction") SubClassOf( ) # Class: (cell adhesion involved in heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") Annotation( "PMID:16860783") "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart.") AnnotationAssertion(rdfs:label "cell adhesion involved in heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cell adhesion involved in heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") Annotation( "PMID:16860783") "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart.") AnnotationAssertion(rdfs:label "regulation of cell adhesion involved in heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (neural precursor cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.") AnnotationAssertion(rdfs:label "neural precursor cell proliferation") SubClassOf( ) +# Class: (trabecula morphogenesis) + +AnnotationAssertion(Annotation( "GOC:dph") "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.") +AnnotationAssertion(rdfs:label "trabecula morphogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (heart trabecula morphogenesis) + +AnnotationAssertion(Annotation( "GOC:dph") "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.") +AnnotationAssertion(rdfs:label "heart trabecula morphogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (fibroblast proliferation involved in heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart.") AnnotationAssertion(rdfs:label "fibroblast proliferation involved in heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (connective tissue development) +AnnotationAssertion(Annotation( "GOC:BHF") "The progression of a connective tissue over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "connective tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (trophoblast cell migration) +AnnotationAssertion(Annotation( "GOC:dph") "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst.") AnnotationAssertion(rdfs:label "trophoblast cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (interstitial cell of Cajal differentiation) + +AnnotationAssertion(Annotation( "GOC:dph") "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction.") +AnnotationAssertion(rdfs:label "interstitial cell of Cajal differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (reproductive system development) +AnnotationAssertion(Annotation( "GOC:dph") "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.") AnnotationAssertion(rdfs:label "reproductive system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein localization to lysosome) +AnnotationAssertion(Annotation( "GOC:dph") "A process in which a protein is transported to, or maintained in, a location within a lysosome.") AnnotationAssertion(rdfs:label "protein localization to lysosome") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of type B pancreatic cell proliferation) + +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation.") +AnnotationAssertion(rdfs:label "regulation of type B pancreatic cell proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (hematopoietic stem cell homeostasis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:21508411") "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells.") AnnotationAssertion(rdfs:label "hematopoietic stem cell homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein localization to cilium) +AnnotationAssertion(Annotation( "GOC:dph") "A process in which a protein is transported to, or maintained in, a location within a cilium.") AnnotationAssertion(rdfs:label "protein localization to cilium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23046,6 +30279,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (myeloid cell development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "myeloid cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23053,17 +30287,28 @@ SubClassOf( ObjectSomeValuesFrom( (macrophage homeostasis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "PMID:21727904") "The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.") AnnotationAssertion(rdfs:label "macrophage homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cilium disassembly) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dph") Annotation( "PMID:17604723") Annotation( "PMID:27350441") "A cellular process that results in the breakdown of a cilium.") +AnnotationAssertion(rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent.") AnnotationAssertion(rdfs:label "cilium disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (hindgut development) + +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut.") +AnnotationAssertion(rdfs:label "hindgut development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (ganglion development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "ganglion development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23071,6 +30316,7 @@ SubClassOf( ObjectSomeValuesFrom( (sympathetic ganglion development) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:rl") "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "sympathetic ganglion development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23078,6 +30324,7 @@ SubClassOf( ObjectSomeValuesFrom( (cranial ganglion development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "cranial ganglion development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23085,12 +30332,14 @@ SubClassOf( ObjectSomeValuesFrom( (trigeminal ganglion development) +AnnotationAssertion(Annotation( "GOC:dph") "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "trigeminal ganglion development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (ganglion morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structures of ganglion are generated and organized.") AnnotationAssertion(rdfs:label "ganglion morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23098,6 +30347,7 @@ SubClassOf( ObjectSomeValuesFrom( (ganglion maturation) +AnnotationAssertion(Annotation( "GOC:dph") "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state.") AnnotationAssertion(rdfs:label "ganglion maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23105,6 +30355,7 @@ SubClassOf( ObjectSomeValuesFrom( (ganglion formation) +AnnotationAssertion(Annotation( "GOC:dph") "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts.") AnnotationAssertion(rdfs:label "ganglion formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23112,6 +30363,7 @@ SubClassOf( ObjectSomeValuesFrom( (trigeminal ganglion morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structure of a trigeminal ganglion is generated and organized.") AnnotationAssertion(rdfs:label "trigeminal ganglion morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23120,6 +30372,7 @@ SubClassOf( ObjectSomeValuesFrom( (trigeminal ganglion maturation) +AnnotationAssertion(Annotation( "GOC:dph") "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state.") AnnotationAssertion(rdfs:label "trigeminal ganglion maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23128,6 +30381,7 @@ SubClassOf( ObjectSomeValuesFrom( (cranial ganglion maturation) +AnnotationAssertion(Annotation( "GOC:dph") "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state.") AnnotationAssertion(rdfs:label "cranial ganglion maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23136,6 +30390,7 @@ SubClassOf( ObjectSomeValuesFrom( (cranial ganglion morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "The process in which the anatomical structure of a cranial ganglion is generated and organized.") AnnotationAssertion(rdfs:label "cranial ganglion morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23144,6 +30399,7 @@ SubClassOf( ObjectSomeValuesFrom( (cranial ganglion formation) +AnnotationAssertion(Annotation( "GOC:dph") "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts.") AnnotationAssertion(rdfs:label "cranial ganglion formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23151,6 +30407,7 @@ SubClassOf( ObjectSomeValuesFrom( (trigeminal ganglion formation) +AnnotationAssertion(Annotation( "GOC:dph") "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts.") AnnotationAssertion(rdfs:label "trigeminal ganglion formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23158,18 +30415,35 @@ SubClassOf( ObjectSomeValuesFrom( (actin filament bundle organization) +AnnotationAssertion(Annotation( "GOC:dph") "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.") AnnotationAssertion(rdfs:label "actin filament bundle organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (colon epithelial cell migration) + +AnnotationAssertion(Annotation( "GOC:dph") "The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism.") +AnnotationAssertion(rdfs:label "colon epithelial cell migration") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (corneal epithelial cell migration) +AnnotationAssertion(Annotation( "GOC:dph") "The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism.") AnnotationAssertion(rdfs:label "corneal epithelial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (intestinal epithelial cell migration) + +AnnotationAssertion(Annotation( "GOC:dph") "The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism.") +AnnotationAssertion(rdfs:label "intestinal epithelial cell migration") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (pharyngeal arch artery morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:dph") Annotation( "PMID:20122914") "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.") AnnotationAssertion(rdfs:label "pharyngeal arch artery morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23177,59 +30451,88 @@ SubClassOf( ObjectSomeValuesFrom( (secretory granule maturation) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:bf") Annotation( "GOC:dph") Annotation( "PMID:16618809") "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling.") AnnotationAssertion(rdfs:label "secretory granule maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of neuroblast migration) +AnnotationAssertion(Annotation( "PMID:23149556") "Any process that modulates the frequency, rate or extent of neuroblast migration.") AnnotationAssertion(rdfs:label "regulation of neuroblast migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of neuroblast migration) +AnnotationAssertion(Annotation( "PMID:23149556") "Any process that activates or increases the frequency, rate or extent of neuroblast migration.") AnnotationAssertion(rdfs:label "positive regulation of neuroblast migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of neuroblast migration) +AnnotationAssertion(Annotation( "PMID:23149556") "Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration.") AnnotationAssertion(rdfs:label "negative regulation of neuroblast migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (glial cell activation) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:18723082") "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.") AnnotationAssertion(rdfs:label "glial cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (protein localization to somatodendritic compartment) +AnnotationAssertion(Annotation( "PMID:18341993") "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment.") AnnotationAssertion(rdfs:label "protein localization to somatodendritic compartment") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (establishment of protein localization to plasma membrane) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:vw") "The directed movement of a protein to a specific location in a plasma membrane.") AnnotationAssertion(rdfs:label "establishment of protein localization to plasma membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (replacement bone morphogenesis) +AnnotationAssertion(Annotation( "PMID:29852585") "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone.") AnnotationAssertion(rdfs:label "replacement bone morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (dermal bone morphogenesis) +AnnotationAssertion(Annotation( "PMID:12588850") Annotation( "PMID:15003632") "The process in which bone which forms superficially in the organism are generated and organized.") AnnotationAssertion(rdfs:label "dermal bone morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (membrane bone morphogenesis) +AnnotationAssertion(Annotation( "PMID:14579374") "The process in which bone which forms deep in the organism are generated and organized.") AnnotationAssertion(rdfs:label "membrane bone morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of small molecule metabolic process) + +AnnotationAssertion(Annotation( "GOC:vw") "Any process that modulates the rate, frequency or extent of a small molecule metabolic process.") +AnnotationAssertion(rdfs:label "regulation of small molecule metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of small molecule metabolic process) + +AnnotationAssertion(Annotation( "GOC:vw") "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process.") +AnnotationAssertion(rdfs:label "positive regulation of small molecule metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of small molecule metabolic process) + +AnnotationAssertion(Annotation( "GOC:vw") "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process.") +AnnotationAssertion(rdfs:label "negative regulation of small molecule metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (collagen-containing extracellular matrix) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:rph") Annotation( "PMID:21123617") "An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.") AnnotationAssertion(rdfs:label "collagen-containing extracellular matrix") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -23237,38 +30540,46 @@ SubClassOf( ObjectAllValuesFrom( (positive regulation of mitotic sister chromatid segregation) +AnnotationAssertion(Annotation( "PMID:12773390") "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.") AnnotationAssertion(rdfs:label "positive regulation of mitotic sister chromatid segregation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (stomach development) +AnnotationAssertion(Annotation( "PMID:11967278") "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ.") AnnotationAssertion(rdfs:label "stomach development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (detection of stimulus involved in sensory perception of pain) +AnnotationAssertion(Annotation( "PMID:19837031") "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal.") AnnotationAssertion(rdfs:label "detection of stimulus involved in sensory perception of pain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to postsynapse) +AnnotationAssertion(Annotation( "PMID:31189538") "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell.") AnnotationAssertion(rdfs:label "protein localization to postsynapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (intracellular protein transmembrane transport) +AnnotationAssertion(Annotation( "GOC:isa_complete") "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.") +AnnotationAssertion(rdfs:comment "Note that this term is not intended for use in annotating lateral movement within membranes.") AnnotationAssertion(rdfs:label "intracellular protein transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (protein-containing complex assembly) +AnnotationAssertion(Annotation( "GOC:jl") "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.") AnnotationAssertion(rdfs:label "protein-containing complex assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein-DNA complex assembly) +AnnotationAssertion(Annotation( "GOC:jl") "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.") AnnotationAssertion(rdfs:label "protein-DNA complex assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23276,11 +30587,20 @@ SubClassOf( (biological regulation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") Annotation( "GOC:mah") Annotation( "GOC:pr") Annotation( "GOC:vw") "Any process that modulates a measurable attribute of any biological process, quality or function.") AnnotationAssertion(rdfs:label "biological regulation") SubClassOf( ) +# Class: (regulation of molecular function) + +AnnotationAssertion(Annotation( "GOC:isa_complete") "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.") +AnnotationAssertion(rdfs:label "regulation of molecular function") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (extracellular membrane-bounded organelle) +AnnotationAssertion(Annotation( "GOC:isa_complete") "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.") AnnotationAssertion(rdfs:label "extracellular membrane-bounded organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23288,34 +30608,40 @@ SubClassOf( (intracellular organelle lumen) +AnnotationAssertion(Annotation( "GOC:mah") "An organelle lumen that is part of an intracellular organelle.") AnnotationAssertion(rdfs:label "intracellular organelle lumen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (neuron cellular homeostasis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.") AnnotationAssertion(rdfs:label "neuron cellular homeostasis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (extracellular exosome) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") Annotation( "GOC:vesicles") Annotation( "PMID:15908444") Annotation( "PMID:17641064") Annotation( "PMID:19442504") Annotation( "PMID:19498381") Annotation( "PMID:22418571") Annotation( "PMID:24009894") "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.") AnnotationAssertion(rdfs:label "extracellular exosome") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (glucagon secretion) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:rl") "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).") AnnotationAssertion(rdfs:label "glucagon secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of glucagon secretion) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the regulated release of glucagon.") AnnotationAssertion(rdfs:label "regulation of glucagon secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of glucagon secretion) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.") AnnotationAssertion(rdfs:label "negative regulation of glucagon secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23323,6 +30649,7 @@ SubClassOf( (positive regulation of glucagon secretion) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.") AnnotationAssertion(rdfs:label "positive regulation of glucagon secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23330,81 +30657,135 @@ SubClassOf( (anchoring junction) +AnnotationAssertion(Annotation( "ISBN:0815332181") "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.") AnnotationAssertion(rdfs:label "anchoring junction") SubClassOf( ) # Class: (chromosome organization involved in meiotic cell cycle) +AnnotationAssertion(Annotation( "GOC:mah") "A process of chromosome organization that is involved in a meiotic cell cycle.") AnnotationAssertion(rdfs:label "chromosome organization involved in meiotic cell cycle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (establishment of protein localization to chromosome) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "The directed movement of a protein to a specific location on a chromosome.") AnnotationAssertion(rdfs:label "establishment of protein localization to chromosome") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of establishment of protein localization) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.") AnnotationAssertion(rdfs:label "regulation of establishment of protein localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of establishment of protein localization to chromosome) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome.") AnnotationAssertion(rdfs:label "regulation of establishment of protein localization to chromosome") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (lymphocyte apoptotic process) +AnnotationAssertion(Annotation( "CL:0000542") Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") Annotation( "ISBN:0781765196") "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.") +AnnotationAssertion(rdfs:comment "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).") AnnotationAssertion(rdfs:label "lymphocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of lymphocyte apoptotic process) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") Annotation( "ISBN:0781765196") "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process.") +AnnotationAssertion(rdfs:comment "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).") AnnotationAssertion(rdfs:label "regulation of lymphocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of lymphocyte apoptotic process) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") Annotation( "ISBN:0781765196") "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process.") +AnnotationAssertion(rdfs:comment "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).") AnnotationAssertion(rdfs:label "negative regulation of lymphocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of lymphocyte apoptotic process) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") Annotation( "ISBN:0781765196") "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process.") +AnnotationAssertion(rdfs:comment "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).") AnnotationAssertion(rdfs:label "positive regulation of lymphocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (T cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000084") Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") Annotation( "ISBN:0781765196") "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.") AnnotationAssertion(rdfs:label "T cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of T cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") Annotation( "ISBN:0781765196") "Any process that modulates the occurrence or rate of T cell death by apoptotic process.") AnnotationAssertion(rdfs:label "regulation of T cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of T cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") Annotation( "ISBN:0781765196") "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of T cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of T cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mtg_apoptosis") Annotation( "ISBN:0781765196") "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of T cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (somatostatin secretion) +AnnotationAssertion(Annotation( "GOC:mah") "The regulated release of somatostatin from secretory granules in the D cells of the pancreas.") AnnotationAssertion(rdfs:label "somatostatin secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (mucus secretion) + +AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:068340007X") Annotation( "ISBN:0721662544") "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function.") +AnnotationAssertion(rdfs:label "mucus secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (regulation of mucus secretion) + +AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.") +AnnotationAssertion(rdfs:label "regulation of mucus secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (negative regulation of mucus secretion) + +AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.") +AnnotationAssertion(rdfs:label "negative regulation of mucus secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of mucus secretion) + +AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.") +AnnotationAssertion(rdfs:label "positive regulation of mucus secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (pigment cell development) +AnnotationAssertion(Annotation( "GOC:cvs") "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate.") AnnotationAssertion(rdfs:label "pigment cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23412,60 +30793,98 @@ SubClassOf( ObjectSomeValuesFrom( (fat cell proliferation) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:sl") "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat.") AnnotationAssertion(rdfs:label "fat cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of fat cell proliferation) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:sl") "Any process that modulates the frequency, rate or extent of fat cell proliferation.") AnnotationAssertion(rdfs:label "regulation of fat cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of fat cell proliferation) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:sl") "Any process that stops or decreases the rate or extent of fat cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of fat cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of fat cell proliferation) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:sl") "Any process that activates or increases the rate or extent of fat cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of fat cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (hepatocyte differentiation) + +AnnotationAssertion(Annotation( "CL:0000182") Annotation( "PMID:7588884") "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.") +AnnotationAssertion(rdfs:label "hepatocyte differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (regulation of hepatocyte differentiation) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:sl") "Any process that modulates the frequency, rate or extent of hepatocyte differentiation.") +AnnotationAssertion(rdfs:label "regulation of hepatocyte differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of hepatocyte differentiation) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:sl") "Any process that stops or decreases the rate or extent of hepatocyte differentiation.") +AnnotationAssertion(rdfs:label "negative regulation of hepatocyte differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (positive regulation of hepatocyte differentiation) + +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:sl") "Any process that activates or increases the rate or extent of hepatocyte differentiation.") +AnnotationAssertion(rdfs:label "positive regulation of hepatocyte differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (exocytic vesicle) +AnnotationAssertion(Annotation( "GOC:kad") Annotation( "GOC:mah") "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.") AnnotationAssertion(rdfs:label "exocytic vesicle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (response to oxygen levels) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.") AnnotationAssertion(rdfs:label "response to oxygen levels") SubClassOf( ) # Class: (detection of hypoxia) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.") AnnotationAssertion(rdfs:label "detection of hypoxia") SubClassOf( ) SubClassOf( ) # Class: (regulation of microtubule cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.") AnnotationAssertion(rdfs:label "regulation of microtubule cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (transepithelial transport) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:yaf") Annotation( "ISBN:0716731363") "The directed movement of a substance from one side of an epithelium to the other.") AnnotationAssertion(rdfs:label "transepithelial transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (transepithelial ammonium transport) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:yaf") "The directed movement of ammonium ions from one side of an epithelium to the other.") AnnotationAssertion(rdfs:label "transepithelial ammonium transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (leukocyte proliferation) +AnnotationAssertion(Annotation( "GOC:add") "The expansion of a leukocyte population by cell division.") AnnotationAssertion(rdfs:label "leukocyte proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23474,18 +30893,21 @@ SubClassOf( ObjectAllValuesFrom( (regulation of leukocyte proliferation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of leukocyte proliferation.") AnnotationAssertion(rdfs:label "regulation of leukocyte proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of leukocyte proliferation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.") AnnotationAssertion(rdfs:label "negative regulation of leukocyte proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of leukocyte proliferation) +AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.") AnnotationAssertion(rdfs:label "positive regulation of leukocyte proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23493,29 +30915,92 @@ SubClassOf( (cellular macromolecule localization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.") AnnotationAssertion(rdfs:label "cellular macromolecule localization") SubClassOf( ) SubClassOf( ) # Class: (basement membrane assembly) +AnnotationAssertion(Annotation( "GOC:mah") "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue.") +AnnotationAssertion(rdfs:comment "Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer.") AnnotationAssertion(rdfs:label "basement membrane assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of bile acid biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.") +AnnotationAssertion(rdfs:label "regulation of bile acid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (negative regulation of bile acid biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.") +AnnotationAssertion(rdfs:label "negative regulation of bile acid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of bile acid biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.") +AnnotationAssertion(rdfs:label "positive regulation of bile acid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (regulation of glycogen metabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen.") +AnnotationAssertion(rdfs:label "regulation of glycogen metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (negative regulation of glycogen metabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen.") +AnnotationAssertion(rdfs:label "negative regulation of glycogen metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of glycogen metabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen.") +AnnotationAssertion(rdfs:label "positive regulation of glycogen metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (cellular response to chemical stimulus) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "cellular response to chemical stimulus") SubClassOf( ) SubClassOf( ) # Class: (organelle assembly) +AnnotationAssertion(Annotation( "GOC:mah") "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.") AnnotationAssertion(rdfs:label "organelle assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (bone maturation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mah") "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state.") AnnotationAssertion(rdfs:label "bone maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23523,96 +31008,128 @@ SubClassOf( ObjectSomeValuesFrom( (protein localization to chromatin) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.") AnnotationAssertion(rdfs:label "protein localization to chromatin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (establishment of protein localization to chromatin) +AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of a protein to a part of a chromosome that is organized into chromatin.") AnnotationAssertion(rdfs:label "establishment of protein localization to chromatin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cellular response to ammonium ion) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000071") Annotation( "PMID:23509267") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.") AnnotationAssertion(rdfs:label "cellular response to ammonium ion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular response to carbohydrate stimulus) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.") AnnotationAssertion(rdfs:label "cellular response to carbohydrate stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (cellular response to hexose stimulus) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.") +AnnotationAssertion(rdfs:label "cellular response to hexose stimulus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (cellular response to glucose stimulus) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.") +AnnotationAssertion(rdfs:label "cellular response to glucose stimulus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (cellular response to peptide hormone stimulus) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.") AnnotationAssertion(rdfs:label "cellular response to peptide hormone stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular response to glucagon stimulus) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.") AnnotationAssertion(rdfs:label "cellular response to glucagon stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular response to steroid hormone stimulus) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.") AnnotationAssertion(rdfs:label "cellular response to steroid hormone stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular response to lipid) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.") AnnotationAssertion(rdfs:label "cellular response to lipid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular response to organonitrogen compound) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.") AnnotationAssertion(rdfs:label "cellular response to organonitrogen compound") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (cellular response to amine stimulus) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.") AnnotationAssertion(rdfs:label "cellular response to amine stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (hematopoietic stem cell proliferation) +AnnotationAssertion(Annotation( "CL:0000037") Annotation( "GOC:BHF") Annotation( "GOC:add") Annotation( "GOC:mah") Annotation( "GOC:rl") "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.") AnnotationAssertion(rdfs:label "hematopoietic stem cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cellular response to endogenous stimulus) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "cellular response to endogenous stimulus") SubClassOf( ) # Class: (granulocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:rph") "The movement of a granulocyte in response to an external stimulus.") AnnotationAssertion(rdfs:label "granulocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of granulocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.") AnnotationAssertion(rdfs:label "regulation of granulocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of granulocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.") AnnotationAssertion(rdfs:label "negative regulation of granulocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of granulocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.") AnnotationAssertion(rdfs:label "positive regulation of granulocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mastication) +AnnotationAssertion(Annotation( "GOC:gvg") "The process of biting and mashing food with the teeth prior to swallowing.") AnnotationAssertion(rdfs:label "mastication") SubClassOf( ) # Class: (smooth muscle cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of a smooth muscle cell in response to an external stimulus.") AnnotationAssertion(rdfs:label "smooth muscle cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23620,47 +31137,56 @@ SubClassOf( (regulation of smooth muscle cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis.") AnnotationAssertion(rdfs:label "regulation of smooth muscle cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of smooth muscle cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis.") AnnotationAssertion(rdfs:label "negative regulation of smooth muscle cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of smooth muscle cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis.") AnnotationAssertion(rdfs:label "positive regulation of smooth muscle cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mononuclear cell migration) +AnnotationAssertion(Annotation( "GOC:mah") "The movement of a mononuclear cell within or between different tissues and organs of the body.") AnnotationAssertion(rdfs:label "mononuclear cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of mononuclear cell migration) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.") AnnotationAssertion(rdfs:label "regulation of mononuclear cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of mononuclear cell migration) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.") AnnotationAssertion(rdfs:label "negative regulation of mononuclear cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of mononuclear cell migration) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.") AnnotationAssertion(rdfs:label "positive regulation of mononuclear cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to extracellular region) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location.") AnnotationAssertion(rdfs:label "protein localization to extracellular region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (anatomical structure maturation) +AnnotationAssertion(Annotation( "GOC:mah") "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state.") AnnotationAssertion(rdfs:label "anatomical structure maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23668,6 +31194,7 @@ SubClassOf( ObjectSomeValuesFrom( (ectodermal placode development) +AnnotationAssertion(Annotation( "GOC:mah") "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.") AnnotationAssertion(rdfs:label "ectodermal placode development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23675,6 +31202,7 @@ SubClassOf( (ectodermal placode morphogenesis) +AnnotationAssertion(Annotation( "GOC:mah") "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.") AnnotationAssertion(rdfs:label "ectodermal placode morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23683,12 +31211,14 @@ SubClassOf( ObjectSomeValuesFrom( (nitrogen compound transport) +AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "nitrogen compound transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (membrane assembly) +AnnotationAssertion(Annotation( "GOC:mah") "The aggregation, arrangement and bonding together of a set of components to form a membrane.") AnnotationAssertion(rdfs:label "membrane assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23696,12 +31226,15 @@ SubClassOf( ObjectSomeValuesFrom( (basement membrane organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane.") +AnnotationAssertion(rdfs:comment "Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer.") AnnotationAssertion(rdfs:label "basement membrane organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (nuclear membrane organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.") AnnotationAssertion(rdfs:label "nuclear membrane organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23709,6 +31242,7 @@ SubClassOf( ObjectSomeValuesFrom( (nuclear outer membrane organization) +AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane.") AnnotationAssertion(rdfs:label "nuclear outer membrane organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23716,46 +31250,60 @@ SubClassOf( ObjectSomeValuesFrom( (protein transmembrane transport) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:vw") "The process in which a protein is transported across a membrane.") +AnnotationAssertion(rdfs:comment "Note that this term is not intended for use in annotating lateral movement within membranes.") AnnotationAssertion(rdfs:label "protein transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (protein-DNA complex organization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex.") AnnotationAssertion(rdfs:label "protein-DNA complex organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein-RNA complex organization) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex.") AnnotationAssertion(rdfs:label "protein-RNA complex organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular component organization or biogenesis) +AnnotationAssertion(Annotation( "GOC:mah") "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "cellular component organization or biogenesis") SubClassOf( ) # Class: (response to catecholamine) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.") AnnotationAssertion(rdfs:label "response to catecholamine") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular response to catecholamine stimulus) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.") AnnotationAssertion(rdfs:label "cellular response to catecholamine stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (response to norepinephrine) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.") +AnnotationAssertion(rdfs:comment "Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.") AnnotationAssertion(rdfs:label "response to norepinephrine") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular response to norepinephrine stimulus) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.") +AnnotationAssertion(rdfs:comment "Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.") AnnotationAssertion(rdfs:label "cellular response to norepinephrine stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (leukocyte apoptotic process) +AnnotationAssertion(Annotation( "CL:0000738") Annotation( "GOC:BHF") Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.") +AnnotationAssertion(rdfs:comment "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).") AnnotationAssertion(rdfs:label "leukocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23764,6 +31312,8 @@ SubClassOf( ObjectAllValuesFrom( (macrophage apoptotic process) +AnnotationAssertion(Annotation( "CL:0000235") Annotation( "GOC:BHF") Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues.") +AnnotationAssertion(rdfs:comment "Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).") AnnotationAssertion(rdfs:label "macrophage apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23771,28 +31321,40 @@ SubClassOf( (DNA biosynthetic process) +AnnotationAssertion(Annotation( "GOC:mah") "The biosynthetic process resulting in the formation of DNA.") AnnotationAssertion(rdfs:label "DNA biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell periphery) +AnnotationAssertion(Annotation( "GOC:pdt") "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures.") AnnotationAssertion(rdfs:label "cell periphery") SubClassOf( ) # Class: (elastic fiber) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") Annotation( "PMID:20236620") "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.") AnnotationAssertion(rdfs:label "elastic fiber") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (extracellular exosome assembly) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:tfm") Annotation( "PMID:19442504") Annotation( "PMID:27462458") "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm.") AnnotationAssertion(rdfs:label "extracellular exosome assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (renal system development) + +AnnotationAssertion(Annotation( "GOC:mtg_kidney_jan10") Annotation( "GOC:yaf") Annotation( "PMID:6996269") "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels.") +AnnotationAssertion(rdfs:label "renal system development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (stem cell proliferation) +AnnotationAssertion(Annotation( "GOC:mtg_kidney_jan10") "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.") AnnotationAssertion(rdfs:label "stem cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23800,11 +31362,13 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of stem cell proliferation) +AnnotationAssertion(Annotation( "GOC:mtg_kidney_jan10") "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.") AnnotationAssertion(rdfs:label "regulation of stem cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mesenchyme morphogenesis) +AnnotationAssertion(Annotation( "GOC:mtg_kidney_jan10") "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells.") AnnotationAssertion(rdfs:label "mesenchyme morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23813,25 +31377,43 @@ SubClassOf( ObjectSomeValuesFrom( (epithelial tube formation) +AnnotationAssertion(Annotation( "GOC:mtg_kidney_jan10") "The developmental process pertaining to the initial formation of an epithelial tube.") AnnotationAssertion(rdfs:label "epithelial tube formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of mesenchymal cell proliferation) +AnnotationAssertion(Annotation( "GOC:mtg_kidney_jan10") "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.") AnnotationAssertion(rdfs:label "negative regulation of mesenchymal cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (monocarboxylic acid catabolic process) + +AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.") +AnnotationAssertion(rdfs:label "monocarboxylic acid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (monocarboxylic acid biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.") +AnnotationAssertion(rdfs:label "monocarboxylic acid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (circulatory system development) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "UBERON:0001009") "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.") AnnotationAssertion(rdfs:label "circulatory system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (vascular cord development) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:7084422") Annotation( "ZFA:0005077") "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis.") AnnotationAssertion(rdfs:label "vascular cord development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23839,115 +31421,160 @@ SubClassOf( ObjectSomeValuesFrom( (organelle transport along microtubule) +AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.") AnnotationAssertion(rdfs:label "organelle transport along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (ammonium transmembrane transport) +AnnotationAssertion(Annotation( "GOC:mah") "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+.") +AnnotationAssertion(rdfs:comment "Note that this term is not intended for use in annotating lateral movement within membranes.") AnnotationAssertion(rdfs:label "ammonium transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (fibroblast activation) +AnnotationAssertion(Annotation( "CL:0000057") Annotation( "GOC:BHF") Annotation( "GOC:mah") "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.") AnnotationAssertion(rdfs:label "fibroblast activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (type B pancreatic cell maturation) + +AnnotationAssertion(Annotation( "CL:0000169") Annotation( "GOC:BHF") "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.") +AnnotationAssertion(rdfs:comment "These processes continue to 60 DPA in Gossypium spp.") +AnnotationAssertion(rdfs:label "type B pancreatic cell maturation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (epithelial cell proliferation involved in liver morphogenesis) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver.") +AnnotationAssertion(rdfs:label "epithelial cell proliferation involved in liver morphogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (liver morphogenesis) + +AnnotationAssertion(Annotation( "GOC:mah") "The process in which the anatomical structures of the liver are generated and organized.") +AnnotationAssertion(rdfs:label "liver morphogenesis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (endothelial cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000115") Annotation( "GOC:BHF") Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal.") AnnotationAssertion(rdfs:label "endothelial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (oxygen metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways involving diatomic oxygen (O2).") AnnotationAssertion(rdfs:label "oxygen metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (establishment of protein localization to organelle) +AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.") AnnotationAssertion(rdfs:label "establishment of protein localization to organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein localization to membrane) +AnnotationAssertion(Annotation( "GOC:mah") "A process in which a protein is transported to, or maintained in, a specific location in a membrane.") AnnotationAssertion(rdfs:label "protein localization to membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein localization to plasma membrane) +AnnotationAssertion(Annotation( "GOC:mah") "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.") AnnotationAssertion(rdfs:label "protein localization to plasma membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (protein localization to vacuole) +AnnotationAssertion(Annotation( "GOC:ecd") "A process in which a protein is transported to, or maintained at, a location in a vacuole.") AnnotationAssertion(rdfs:label "protein localization to vacuole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (establishment of protein localization to vacuole) +AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of a protein to a specific location in a vacuole.") AnnotationAssertion(rdfs:label "establishment of protein localization to vacuole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (multinuclear osteoclast differentiation) +AnnotationAssertion(Annotation( "CL:0000779") Annotation( "GOC:mah") Annotation( "PMID:12713016") "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.") AnnotationAssertion(rdfs:label "multinuclear osteoclast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lymphocyte migration) +AnnotationAssertion(Annotation( "CL:0000542") Annotation( "GOC:BHF") Annotation( "GOC:mah") "The movement of a lymphocyte within or between different tissues and organs of the body.") AnnotationAssertion(rdfs:label "lymphocyte migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (T cell migration) +AnnotationAssertion(Annotation( "CL:0000084") Annotation( "GOC:BHF") Annotation( "GOC:mah") "The movement of a T cell within or between different tissues and organs of the body.") AnnotationAssertion(rdfs:label "T cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein localization to cell cortex) +AnnotationAssertion(Annotation( "GOC:mah") "A process in which a protein is transported to, or maintained in, the cell cortex.") AnnotationAssertion(rdfs:label "protein localization to cell cortex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (protein localization to microtubule cytoskeleton) +AnnotationAssertion(Annotation( "GOC:mah") "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton.") AnnotationAssertion(rdfs:label "protein localization to microtubule cytoskeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of primary metabolic process) +AnnotationAssertion(Annotation( "PMID:19211694") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.") AnnotationAssertion(rdfs:label "regulation of primary metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of response to stress) +AnnotationAssertion(Annotation( "GOC:dhl") "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "regulation of response to stress") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of fertilization) +AnnotationAssertion(Annotation( "GOC:DHL") Annotation( "PMID:20478994") "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).") AnnotationAssertion(rdfs:label "regulation of fertilization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lytic vacuole organization) +AnnotationAssertion(Annotation( "PMID:20729380") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole.") AnnotationAssertion(rdfs:label "lytic vacuole organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (extracellular matrix assembly) +AnnotationAssertion(Annotation( "GOC:jl") "The aggregation, arrangement and bonding together of the extracellular matrix.") AnnotationAssertion(rdfs:label "extracellular matrix assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23955,12 +31582,14 @@ SubClassOf( (cardiac muscle cell action potential) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "An action potential that occurs in a cardiac muscle cell.") AnnotationAssertion(rdfs:label "cardiac muscle cell action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (SA node cell action potential) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "An action potential that occurs in a sinoatrial node cardiac muscle cell.") AnnotationAssertion(rdfs:label "SA node cell action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23968,6 +31597,7 @@ SubClassOf( ObjectSomeValuesFrom( (AV node cell action potential) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "An action potential that occurs in an atrioventricular node cardiac muscle cell.") AnnotationAssertion(rdfs:label "AV node cell action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23975,6 +31605,7 @@ SubClassOf( ObjectSomeValuesFrom( (Purkinje myocyte action potential) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "An action potential that occurs in a Purkinje myocyte.") AnnotationAssertion(rdfs:label "Purkinje myocyte action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -23982,23 +31613,27 @@ SubClassOf( ObjectSomeValuesFrom( (SA node cell to atrial cardiac muscle cell signaling) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte.") AnnotationAssertion(rdfs:label "SA node cell to atrial cardiac muscle cell signaling") SubClassOf( ) SubClassOf( ) # Class: (cell-cell signaling involved in cardiac conduction) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.") AnnotationAssertion(rdfs:label "cell-cell signaling involved in cardiac conduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (AV node cell to bundle of His cell signaling) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.") AnnotationAssertion(rdfs:label "AV node cell to bundle of His cell signaling") SubClassOf( ) SubClassOf( ) # Class: (Purkinje myocyte to ventricular cardiac muscle cell signaling) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.") AnnotationAssertion(rdfs:label "Purkinje myocyte to ventricular cardiac muscle cell signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24006,108 +31641,128 @@ SubClassOf( (cell communication involved in cardiac conduction) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.") AnnotationAssertion(rdfs:label "cell communication involved in cardiac conduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (AV node cell to bundle of His cell communication) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.") AnnotationAssertion(rdfs:label "AV node cell to bundle of His cell communication") SubClassOf( ) # Class: (Purkinje myocyte to ventricular cardiac muscle cell communication) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.") AnnotationAssertion(rdfs:label "Purkinje myocyte to ventricular cardiac muscle cell communication") SubClassOf( ) # Class: (SA node cell to atrial cardiac muscle cell communication) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.") AnnotationAssertion(rdfs:label "SA node cell to atrial cardiac muscle cell communication") SubClassOf( ) # Class: (regulation of monocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis.") AnnotationAssertion(rdfs:label "regulation of monocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of monocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the frequency, rate, or extent of monocyte chemotaxis.") AnnotationAssertion(rdfs:label "positive regulation of monocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of monocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.") AnnotationAssertion(rdfs:label "negative regulation of monocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of microtubule nucleation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.") AnnotationAssertion(rdfs:label "positive regulation of microtubule nucleation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of cell cycle process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.") AnnotationAssertion(rdfs:label "positive regulation of cell cycle process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of ribosome biogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.") AnnotationAssertion(rdfs:label "regulation of ribosome biogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of ribosome biogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.") AnnotationAssertion(rdfs:label "positive regulation of ribosome biogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of ribosome biogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.") AnnotationAssertion(rdfs:label "negative regulation of ribosome biogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of peptide transport) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion(rdfs:label "regulation of peptide transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of extracellular matrix disassembly) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.") AnnotationAssertion(rdfs:label "positive regulation of extracellular matrix disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (tissue migration) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The process in which the population of cells that make up a tissue undergo directed movement.") AnnotationAssertion(rdfs:label "tissue migration") SubClassOf( ) # Class: (epithelium migration) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The process in which the population of cells that make up an epithelium undergo directed movement.") AnnotationAssertion(rdfs:label "epithelium migration") SubClassOf( ) # Class: (regulation of actin cytoskeleton organization by cell-cell adhesion) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.") AnnotationAssertion(rdfs:label "regulation of actin cytoskeleton organization by cell-cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (establishment of protein localization to membrane) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The directed movement of a protein to a specific location in a membrane.") AnnotationAssertion(rdfs:label "establishment of protein localization to membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (establishment of epithelial cell polarity) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The specification and formation of anisotropic intracellular organization of an epithelial cell.") AnnotationAssertion(rdfs:label "establishment of epithelial cell polarity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (Golgi disassembly) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance.") AnnotationAssertion(rdfs:label "Golgi disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24115,6 +31770,7 @@ SubClassOf( ObjectSomeValuesFrom( (Golgi reassembly) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance.") AnnotationAssertion(rdfs:label "Golgi reassembly") SubClassOf( ) SubClassOf( ) @@ -24122,11 +31778,13 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of Golgi inheritance) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division.") AnnotationAssertion(rdfs:label "regulation of Golgi inheritance") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (chondrocyte morphogenesis) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte.") AnnotationAssertion(rdfs:label "chondrocyte morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24134,6 +31792,7 @@ SubClassOf( ObjectSomeValuesFrom( (organelle membrane fusion) +AnnotationAssertion(Annotation( "GOC:ascb_2009") Annotation( "GOC:dph") Annotation( "GOC:tb") "The joining of two lipid bilayers to form a single organelle membrane.") AnnotationAssertion(rdfs:label "organelle membrane fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24142,18 +31801,21 @@ SubClassOf( (regulation of muscle system process) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.") AnnotationAssertion(rdfs:label "regulation of muscle system process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of somatostatin secretion) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.") AnnotationAssertion(rdfs:label "regulation of somatostatin secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of somatostatin secretion) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.") AnnotationAssertion(rdfs:label "positive regulation of somatostatin secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24161,6 +31823,7 @@ SubClassOf( (negative regulation of somatostatin secretion) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.") AnnotationAssertion(rdfs:label "negative regulation of somatostatin secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24168,6 +31831,7 @@ SubClassOf( (regulation of peptide hormone secretion) +AnnotationAssertion(Annotation( "GOC:tb") "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.") AnnotationAssertion(rdfs:label "regulation of peptide hormone secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24175,6 +31839,7 @@ SubClassOf( (positive regulation of peptide hormone secretion) +AnnotationAssertion(Annotation( "GOC:tb") "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.") AnnotationAssertion(rdfs:label "positive regulation of peptide hormone secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24183,6 +31848,7 @@ SubClassOf( (negative regulation of peptide hormone secretion) +AnnotationAssertion(Annotation( "GOC:tb") "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.") AnnotationAssertion(rdfs:label "negative regulation of peptide hormone secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24191,66 +31857,110 @@ SubClassOf( (regulation of osteoclast proliferation) +AnnotationAssertion(Annotation( "GOC:tb") "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.") AnnotationAssertion(rdfs:label "regulation of osteoclast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of osteoclast proliferation) +AnnotationAssertion(Annotation( "GOC:tb") "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.") AnnotationAssertion(rdfs:label "positive regulation of osteoclast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of osteoclast proliferation) +AnnotationAssertion(Annotation( "GOC:tb") "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.") AnnotationAssertion(rdfs:label "negative regulation of osteoclast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of neural crest formation) +AnnotationAssertion(Annotation( "GOC:tb") "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.") AnnotationAssertion(rdfs:label "regulation of neural crest formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of neural crest formation) +AnnotationAssertion(Annotation( "GOC:tb") "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.") AnnotationAssertion(rdfs:label "positive regulation of neural crest formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of neural crest formation) +AnnotationAssertion(Annotation( "GOC:tb") "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.") AnnotationAssertion(rdfs:label "negative regulation of neural crest formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of intracellular protein transport) +AnnotationAssertion(Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.") AnnotationAssertion(rdfs:label "positive regulation of intracellular protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of intracellular protein transport) +AnnotationAssertion(Annotation( "GOC:tb") "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.") AnnotationAssertion(rdfs:label "negative regulation of intracellular protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (regulation of locomotion involved in locomotory behavior) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:kmv") Annotation( "GOC:tb") "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.") +AnnotationAssertion(rdfs:label "regulation of locomotion involved in locomotory behavior") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of locomotion involved in locomotory behavior) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:kmv") Annotation( "GOC:tb") "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.") +AnnotationAssertion(rdfs:label "positive regulation of locomotion involved in locomotory behavior") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (negative regulation of locomotion involved in locomotory behavior) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:kmv") Annotation( "GOC:tb") "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.") +AnnotationAssertion(rdfs:label "negative regulation of locomotion involved in locomotory behavior") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (acinar cell differentiation) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini.") +AnnotationAssertion(rdfs:label "acinar cell differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (protein localization to nuclear envelope) +AnnotationAssertion(Annotation( "GOC:tb") "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.") AnnotationAssertion(rdfs:label "protein localization to nuclear envelope") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (catecholamine uptake) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The directed movement of catecholamine into a cell.") AnnotationAssertion(rdfs:label "catecholamine uptake") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (mesenchymal cell migration) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism.") AnnotationAssertion(rdfs:label "mesenchymal cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (sensory organ morphogenesis) +AnnotationAssertion(Annotation( "GOC:kmv") Annotation( "ISBN:978-0199210893") "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.") AnnotationAssertion(rdfs:label "sensory organ morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24258,46 +31968,63 @@ SubClassOf( ObjectSomeValuesFrom( (RNA localization to nucleus) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:26305931") "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus.") AnnotationAssertion(rdfs:label "RNA localization to nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (pigment granule membrane) +AnnotationAssertion(Annotation( "PMID:11294610") "Any membrane that is part of a pigment granule.") AnnotationAssertion(rdfs:label "pigment granule membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (ciliary plasm) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:cilia") Annotation( "GOC:dos") Annotation( "PMID:17895364") "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.") +AnnotationAssertion(rdfs:comment "Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term \"ciliary plasm\" is not linked to \"cytoplasm\".") AnnotationAssertion(rdfs:label "ciliary plasm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (dendritic cell dendrite assembly) +AnnotationAssertion(Annotation( "CL:0000451") Annotation( "GOC:BHF") Annotation( "PMID:12200351") "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.") +AnnotationAssertion(rdfs:comment "Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals.") AnnotationAssertion(rdfs:label "dendritic cell dendrite assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (dendritic cell differentiation) +AnnotationAssertion(Annotation( "CL:0000451") Annotation( "GOC:pr") "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.") +AnnotationAssertion(rdfs:comment "Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.") AnnotationAssertion(rdfs:label "dendritic cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (dendritic cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000451") Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:15059845") "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.") AnnotationAssertion(rdfs:label "dendritic cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (motor neuron apoptotic process) +AnnotationAssertion(Annotation( "CL:0000100") Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:14523086") "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.") AnnotationAssertion(rdfs:label "motor neuron apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (type B pancreatic cell apoptotic process) + +AnnotationAssertion(Annotation( "CL:0000169") Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:16087305") "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin.") +AnnotationAssertion(rdfs:label "type B pancreatic cell apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (synaptic membrane) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "PMID:20410104") "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.") AnnotationAssertion(rdfs:label "synaptic membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24306,30 +32033,36 @@ SubClassOf( ObjectSomeValuesFrom( (vascular associated smooth muscle cell development) +AnnotationAssertion(Annotation( "GOC:BHF") "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.") AnnotationAssertion(rdfs:label "vascular associated smooth muscle cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (mesenchymal cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000134") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:yaf") Annotation( "PMID:18231833") "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.") AnnotationAssertion(rdfs:label "mesenchymal cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (ammonium ion metabolic process) +AnnotationAssertion(Annotation( "GOC:dhl") Annotation( "GOC:tb") Annotation( "PMID:14671018") "The chemical reactions and pathways involving the ammonium ion.") AnnotationAssertion(rdfs:label "ammonium ion metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (apoptotic signaling pathway) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.") +AnnotationAssertion(rdfs:comment "This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.") AnnotationAssertion(rdfs:label "apoptotic signaling pathway") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (execution phase of apoptosis) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:21760595") "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.") AnnotationAssertion(rdfs:label "execution phase of apoptosis") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -24337,29 +32070,66 @@ SubClassOf( ObjectSomeValuesFrom( (lysosomal membrane organization) +AnnotationAssertion(Annotation( "GOC:yaf") Annotation( "PMID:20544854") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.") AnnotationAssertion(rdfs:label "lysosomal membrane organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (cellular response to toxic substance) + +AnnotationAssertion(Annotation( "GOC:pr") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.") +AnnotationAssertion(rdfs:label "cellular response to toxic substance") + +# Class: (renal tubular secretion) + +AnnotationAssertion(Annotation( "GOC:rph") Annotation( "PMID:25287933") Annotation( "Wikipedia:Renal_secretion#Secretion") "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.") +AnnotationAssertion(rdfs:label "renal tubular secretion") +SubClassOf( ) +SubClassOf( ) + +# Class: (ammonium homeostasis) + +AnnotationAssertion(Annotation( "GOC:yaf") Annotation( "PMID:12695560") "Any biological process involved in the maintenance of an internal steady state of ammonium.") +AnnotationAssertion(rdfs:label "ammonium homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (intracellular ammonium homeostasis) + +AnnotationAssertion(Annotation( "GOC:yaf") Annotation( "PMID:12695560") "A homeostatic process involved in the maintenance of a steady state level of ammonium within a cell.") +AnnotationAssertion(rdfs:label "intracellular ammonium homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (hepatocyte apoptotic process) + +AnnotationAssertion(Annotation( "CL:0000182") Annotation( "GOC:jc") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:15856020") "Any apoptotic process in a hepatocyte, the main structural component of the liver.") +AnnotationAssertion(rdfs:label "hepatocyte apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (protein localization to heterochromatin) +AnnotationAssertion(Annotation( "GOC:mah") "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin.") AnnotationAssertion(rdfs:label "protein localization to heterochromatin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (glial cell projection) +AnnotationAssertion(Annotation( "GOC:mc") "A prolongation or process extending from a glial cell.") AnnotationAssertion(rdfs:label "glial cell projection") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (neuroblast migration) +AnnotationAssertion(Annotation( "CL:0000031") Annotation( "GOC:jc") Annotation( "PMID:15543145") "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.") AnnotationAssertion(rdfs:label "neuroblast migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (microtubule bundle) +AnnotationAssertion(Annotation( "NIF_Subcellular:sao1872343973") "An arrangement of closely apposed microtubules running parallel to each other.") +AnnotationAssertion( "NIF_Subcellular:sao1872343973") AnnotationAssertion(rdfs:label "microtubule bundle") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -24367,6 +32137,7 @@ SubClassOf( ObjectSomeValuesFrom( (supramolecular fiber organization) +AnnotationAssertion(Annotation( "GOC:pr") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.") AnnotationAssertion(rdfs:label "supramolecular fiber organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24374,65 +32145,76 @@ SubClassOf( (retinal rod cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000604") Annotation( "GOC:jc") Annotation( "PMID:17202487") "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina.") AnnotationAssertion(rdfs:label "retinal rod cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (retinal cone cell apoptotic process) +AnnotationAssertion(Annotation( "CL:0000573") Annotation( "GOC:jc") "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina.") AnnotationAssertion(rdfs:label "retinal cone cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (motor neuron migration) +AnnotationAssertion(Annotation( "CL:0000100") Annotation( "GOC:yaf") Annotation( "PMID:20711475") "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.") AnnotationAssertion(rdfs:label "motor neuron migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (spinal cord motor neuron migration) +AnnotationAssertion(Annotation( "CL:0011001") Annotation( "GOC:yaf") Annotation( "PMID:20711475") "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.") AnnotationAssertion(rdfs:label "spinal cord motor neuron migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (dendritic cell dendrite) +AnnotationAssertion(Annotation( "CL:0000451") Annotation( "GOC:BHF") Annotation( "GOC:cjm") Annotation( "PMID:12200351") "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.") AnnotationAssertion(rdfs:label "dendritic cell dendrite") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cardiac myofibril) +AnnotationAssertion(Annotation( "GOC:cjm") Annotation( "GOC:devbiol") "A cardiac myofibril is a myofibril specific to cardiac muscle cells.") AnnotationAssertion(rdfs:label "cardiac myofibril") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (myeloid leukocyte migration) +AnnotationAssertion(Annotation( "GOC:cvs") Annotation( "PMID:22342843") Annotation( "PMID:24157461") "The movement of a myeloid leukocyte within or between different tissues and organs of the body.") AnnotationAssertion(rdfs:label "myeloid leukocyte migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (granulocyte migration) +AnnotationAssertion(Annotation( "GOC:cvs") Annotation( "PMID:24163421") Annotation( "PMID:24193336") "The movement of a granulocyte within or between different tissues and organs of the body.") AnnotationAssertion(rdfs:label "granulocyte migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lymphoid lineage cell migration) +AnnotationAssertion(Annotation( "GOC:pr") Annotation( "PMID:22342843") "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage.") AnnotationAssertion(rdfs:label "lymphoid lineage cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (vacuole fusion) +AnnotationAssertion(Annotation( "GOC:pr") Annotation( "GOC:vw") Annotation( "Wikipedia:Vacuole") "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole.") AnnotationAssertion(rdfs:label "vacuole fusion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (intracellular vesicle) +AnnotationAssertion(Annotation( "GOC:vesicles") "Any vesicle that is part of the intracellular region.") AnnotationAssertion(rdfs:label "intracellular vesicle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24440,60 +32222,75 @@ SubClassOf( ObjectSomeValuesFrom( (ciliary basal body-plasma membrane docking) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "PMID:13978319") Annotation( "PMID:23348840") Annotation( "PMID:23530209") Annotation( "PMID:25686250") Annotation( "PMID:26981235") "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.") +AnnotationAssertion(rdfs:comment "Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella.") AnnotationAssertion(rdfs:label "ciliary basal body-plasma membrane docking") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vesicle targeting, trans-Golgi to periciliary membrane compartment) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "PMID:20106869") Annotation( "PMID:23351793") Annotation( "PMID:24814148") Annotation( "PMID:26485645") "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces.") AnnotationAssertion(rdfs:label "vesicle targeting, trans-Golgi to periciliary membrane compartment") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (extracellular exosome biogenesis) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:bf") Annotation( "PMID:19442504") Annotation( "PMID:25392495") "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.") AnnotationAssertion(rdfs:label "extracellular exosome biogenesis") SubClassOf( ) # Class: (neuromuscular junction of myotube) +AnnotationAssertion(Annotation( "GOC:dos") "A neuromuscular junction in which the target muscle cell is a myotube.") +AnnotationAssertion(rdfs:comment "In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes.") AnnotationAssertion(rdfs:label "neuromuscular junction of myotube") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (skeletal muscle fiber differentiation) +AnnotationAssertion(Annotation( "GOC:dos") "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract.") AnnotationAssertion(rdfs:label "skeletal muscle fiber differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (bounding membrane of organelle) +AnnotationAssertion(Annotation( "GOC:dos") "The lipid bilayer that forms the outer-most layer of an organelle.") +AnnotationAssertion(rdfs:comment "Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes.") AnnotationAssertion(rdfs:label "bounding membrane of organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (plasma membrane region) +AnnotationAssertion(Annotation( "GOC:dos") "A membrane that is a (regional) part of the plasma membrane.") +AnnotationAssertion(rdfs:comment "Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass.") AnnotationAssertion(rdfs:label "plasma membrane region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell-cell adhesion) +AnnotationAssertion(Annotation( "GOC:dos") "The attachment of one cell to another cell via adhesion molecules.") AnnotationAssertion(rdfs:label "cell-cell adhesion") SubClassOf( ) # Class: (protein complex involved in cell-cell adhesion) +AnnotationAssertion(Annotation( "GOC:dos") "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion.") AnnotationAssertion(rdfs:label "protein complex involved in cell-cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein complex involved in cell adhesion) +AnnotationAssertion(Annotation( "GOC:dos") "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell.") AnnotationAssertion(rdfs:label "protein complex involved in cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (network-forming collagen trimer) +AnnotationAssertion(Annotation( "PMID:21421911") "A collagen trimer that forms networks.") AnnotationAssertion(rdfs:label "network-forming collagen trimer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24502,6 +32299,7 @@ SubClassOf( ObjectSomeValuesFrom( (banded collagen fibril) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:21421911") "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands).") AnnotationAssertion(rdfs:label "banded collagen fibril") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -24509,6 +32307,7 @@ SubClassOf( ObjectSomeValuesFrom( (complex of collagen trimers) +AnnotationAssertion(Annotation( "GOC:dos") "A complex of collagen trimers such as a fibril or collagen network.") AnnotationAssertion(rdfs:label "complex of collagen trimers") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -24516,12 +32315,14 @@ SubClassOf( ObjectSomeValuesFrom( (collagen network) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:21421911") "A supramolecular complex that consists of collagen triple helices associated to form a network.") AnnotationAssertion(rdfs:label "collagen network") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (basement membrane collagen trimer) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:21421911") "Any collagen timer that is part of a basement membrane.") AnnotationAssertion(rdfs:label "basement membrane collagen trimer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -24529,33 +32330,47 @@ SubClassOf( ObjectSomeValuesFrom( (import into cell) +AnnotationAssertion(Annotation( "GOC:dos") "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.") AnnotationAssertion(rdfs:label "import into cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (asymmetric stem cell division) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:18513950") "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity.") AnnotationAssertion(rdfs:label "asymmetric stem cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (skeletal muscle myofibril) +AnnotationAssertion(Annotation( "GOC:dos") "A myofibril of a skeletal muscle fiber.") AnnotationAssertion(rdfs:label "skeletal muscle myofibril") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (germline stem cell asymmetric division) +AnnotationAssertion(Annotation( "GOC:dos") "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes.") AnnotationAssertion(rdfs:label "germline stem cell asymmetric division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (bone cell development) +AnnotationAssertion(Annotation( "GOC:dos") "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.") +AnnotationAssertion(rdfs:comment "Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development.") AnnotationAssertion(rdfs:label "bone cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (detoxification) + +AnnotationAssertion(Annotation( "GOC:dos") "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.") +AnnotationAssertion(rdfs:label "detoxification") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (skin epidermis development) +AnnotationAssertion(Annotation( "GOC:dos") "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "skin epidermis development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24563,6 +32378,7 @@ SubClassOf( ObjectSomeValuesFrom( (presynapse) +AnnotationAssertion(Annotation( "GOC:dos") "The part of a synapse that is part of the presynaptic cell.") AnnotationAssertion(rdfs:label "presynapse") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -24570,6 +32386,7 @@ SubClassOf( ObjectSomeValuesFrom( (postsynapse) +AnnotationAssertion(Annotation( "GOC:dos") "The part of a synapse that is part of the post-synaptic cell.") AnnotationAssertion(rdfs:label "postsynapse") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -24577,6 +32394,7 @@ SubClassOf( ObjectSomeValuesFrom( (membrane protein complex) +AnnotationAssertion(Annotation( "GOC:dos") "Any protein complex that is part of a membrane.") AnnotationAssertion(rdfs:label "membrane protein complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24584,51 +32402,67 @@ SubClassOf( ObjectSomeValuesFrom( (plasma membrane protein complex) +AnnotationAssertion(Annotation( "GOC:dos") "Any protein complex that is part of the plasma membrane.") AnnotationAssertion(rdfs:label "plasma membrane protein complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (regulation of renal system process) + +AnnotationAssertion(Annotation( "GOC:dos") "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system.") +AnnotationAssertion(rdfs:label "regulation of renal system process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (nuclear chromosome segregation) +AnnotationAssertion(Annotation( "GOC:dos") "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.") AnnotationAssertion(rdfs:label "nuclear chromosome segregation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (protein transport along microtubule) +AnnotationAssertion(Annotation( "PMID:25987607") "The directed movement of a protein along a microtubule, mediated by motor proteins.") AnnotationAssertion(rdfs:label "protein transport along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (lytic vacuole membrane) +AnnotationAssertion(Annotation( "GOC:dos") "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell.") AnnotationAssertion(rdfs:label "lytic vacuole membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (actin-based cell projection) +AnnotationAssertion(Annotation( "PMID:15661519") "A cell projection supported by an assembly of actin filaments, and which lacks microtubules.") AnnotationAssertion(rdfs:label "actin-based cell projection") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (intramembranous bone growth) +AnnotationAssertion(Annotation( "PMID:26399686") "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone.") AnnotationAssertion(rdfs:label "intramembranous bone growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (bone growth) +AnnotationAssertion(Annotation( "GOC:dos") "The increase in size or mass of a bone that contributes to the shaping of that bone.") AnnotationAssertion(rdfs:label "bone growth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (postsynaptic actin cytoskeleton) +AnnotationAssertion(Annotation( "GOC:dos") "The actin cytoskeleton that is part of a postsynapse.") AnnotationAssertion(rdfs:label "postsynaptic actin cytoskeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (vesicle-mediated transport to the plasma membrane) +AnnotationAssertion(Annotation( "GOC:dos") "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis.") AnnotationAssertion(rdfs:label "vesicle-mediated transport to the plasma membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -24636,63 +32470,75 @@ SubClassOf( ObjectSomeValuesFrom( (synapse pruning) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:12062020") Annotation( "PMID:18083105") Annotation( "PMID:22632716") Annotation( "PMID:29844190") "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.") AnnotationAssertion(rdfs:label "synapse pruning") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of action potential) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") Annotation( "ISBN:978-0-07-139011-8") "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.") +AnnotationAssertion(rdfs:comment "The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term.") AnnotationAssertion(rdfs:label "regulation of action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of cardiac muscle cell action potential) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:mtg_cardiac_conduct_nov11") "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle cell action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of AV node cell action potential) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.") AnnotationAssertion(rdfs:label "regulation of AV node cell action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of Purkinje myocyte action potential) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.") AnnotationAssertion(rdfs:label "regulation of Purkinje myocyte action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of SA node cell action potential) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_cardiac_conduct_nov11") "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.") AnnotationAssertion(rdfs:label "regulation of SA node cell action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of neuronal action potential) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.") AnnotationAssertion(rdfs:label "regulation of neuronal action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (anterograde trans-synaptic signaling) +AnnotationAssertion(Annotation( "GOC:dos") "Cell-cell signaling from pre to post-synapse, across the synaptic cleft.") AnnotationAssertion(rdfs:label "anterograde trans-synaptic signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (retrograde trans-synaptic signaling) +AnnotationAssertion(Annotation( "GOC:dos") "Cell-cell signaling from post to pre-synapse, across the synaptic cleft.") AnnotationAssertion(rdfs:label "retrograde trans-synaptic signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (retrograde trans-synaptic signaling by lipid) +AnnotationAssertion(Annotation( "GOC:dos") "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand.") AnnotationAssertion(rdfs:label "retrograde trans-synaptic signaling by lipid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (postsynaptic signal transduction) +AnnotationAssertion(Annotation( "GOC:dos") "Signal transduction in which the initial step occurs in a postsynapse.") AnnotationAssertion(rdfs:label "postsynaptic signal transduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24700,29 +32546,34 @@ SubClassOf( ObjectSomeValuesFrom( (presynaptic signal transduction) +AnnotationAssertion(Annotation( "GOC:dos") "Signal transduction in which the initial step occurs in a presynapse.") AnnotationAssertion(rdfs:label "presynaptic signal transduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (postsynaptic actin cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:dos") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.") AnnotationAssertion(rdfs:label "postsynaptic actin cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (postsynapse of neuromuscular junction) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "Wikipedia:Neuromuscular_junction&oldid=723623502") "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma.") AnnotationAssertion(rdfs:label "postsynapse of neuromuscular junction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (neuronal dense core vesicle) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "ISBN:978-0-07-181001-2") Annotation( "Wikipedia:Neuropeptide&oldid=713905176") "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals.") AnnotationAssertion(rdfs:label "neuronal dense core vesicle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (vesicle-mediated transport in synapse) +AnnotationAssertion(Annotation( "GOC:dos") "Any vesicle-mediated transport that occurs in a synapse.") AnnotationAssertion(rdfs:label "vesicle-mediated transport in synapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -24730,112 +32581,134 @@ SubClassOf( ObjectAllValuesFrom( (neuronal dense core vesicle membrane) +AnnotationAssertion(Annotation( "GOC:dos") "The lipid bilayer surrounding a neuronal dense core vesicle.") AnnotationAssertion(rdfs:label "neuronal dense core vesicle membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (neuronal dense core vesicle organization) +AnnotationAssertion(Annotation( "GOC:dos") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle.") AnnotationAssertion(rdfs:label "neuronal dense core vesicle organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (presynapse assembly) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:bf") Annotation( "GOC:dos") Annotation( "PMID:24449494") "The aggregation, arrangement and bonding together of a set of components to form a presynapse.") AnnotationAssertion(rdfs:label "presynapse assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (postsynapse assembly) +AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dos") Annotation( "GOCL:PARL") "The aggregation, arrangement and bonding together of a set of components to form a postsynapse.") AnnotationAssertion(rdfs:label "postsynapse assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (supramolecular complex) +AnnotationAssertion(Annotation( "GOC:dos") "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber.") AnnotationAssertion(rdfs:label "supramolecular complex") SubClassOf( ) # Class: (supramolecular polymer) +AnnotationAssertion(Annotation( "GOC:dos") "A polymeric supramolecular structure.") AnnotationAssertion(rdfs:label "supramolecular polymer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (retrograde trans-synaptic signaling by neuropeptide) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:bf") Annotation( "GOC:dos") Annotation( "PMID:19448629") "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide.") AnnotationAssertion(rdfs:label "retrograde trans-synaptic signaling by neuropeptide") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:bf") Annotation( "GOC:dos") Annotation( "PMID:19448629") "Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (microtubule polymerization based movement) +AnnotationAssertion(Annotation( "GOC:cjm") Annotation( "ISBN:0815316194") "The movement of a cellular component as a result of microtubule polymerization.") AnnotationAssertion(rdfs:label "microtubule polymerization based movement") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (microtubule-based transport) +AnnotationAssertion(Annotation( "GOC:cjm") Annotation( "ISBN:0815316194") "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.") AnnotationAssertion(rdfs:label "microtubule-based transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (microtubule polymerization based protein transport) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:vw") Annotation( "PMID:11018050") "The transport of a protein driven by polymerization of a microtubule to which it is attached.") AnnotationAssertion(rdfs:label "microtubule polymerization based protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (microtubule-based protein transport) +AnnotationAssertion(Annotation( "GOC:vw") "A microtubule-based process that results in the transport of proteins.") AnnotationAssertion(rdfs:label "microtubule-based protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (presynaptic actin cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:dos") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.") AnnotationAssertion(rdfs:label "presynaptic actin cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (presynaptic actin cytoskeleton) +AnnotationAssertion(Annotation( "GOC:dos") "The actin cytoskeleton that is part of a presynapse.") AnnotationAssertion(rdfs:label "presynaptic actin cytoskeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell-cell signaling via exosome) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:19837038") "Cell-cell signaling in which the ligand is carried between cells by an exosome.") AnnotationAssertion(rdfs:label "cell-cell signaling via exosome") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (trans-synaptic signaling via exosome) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:19837038") "Transynaptic signaling in which the ligand is carried across the synapse by an exosome.") AnnotationAssertion(rdfs:label "trans-synaptic signaling via exosome") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (postsynaptic modulation of chemical synaptic transmission) +AnnotationAssertion(Annotation( "GOC:dos") "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.") AnnotationAssertion(rdfs:label "postsynaptic modulation of chemical synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (presynaptic modulation of chemical synaptic transmission) +AnnotationAssertion(Annotation( "GOC:dos") "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.") AnnotationAssertion(rdfs:label "presynaptic modulation of chemical synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (presynapse organization) +AnnotationAssertion(Annotation( "GOC:dos") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse.") AnnotationAssertion(rdfs:label "presynapse organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (postsynapse organization) +AnnotationAssertion(Annotation( "GOC:dos") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.") AnnotationAssertion(rdfs:label "postsynapse organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of presynapse organization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the physical form of a presynapse.") AnnotationAssertion(rdfs:label "regulation of presynapse organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -24843,6 +32716,7 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of postsynapse organization) +AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the physical form of a postsynapse.") AnnotationAssertion(rdfs:label "regulation of postsynapse organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -24850,46 +32724,54 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of trans-synaptic signaling) +AnnotationAssertion(Annotation( "GOC:dos") "Any process that modulates the frequency, rate or extent of trans-synaptic signaling.") AnnotationAssertion(rdfs:label "regulation of trans-synaptic signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (presynaptic cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:dos") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton.") AnnotationAssertion(rdfs:label "presynaptic cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (postsynaptic cytoskeleton organization) +AnnotationAssertion(Annotation( "GOC:dos") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton.") AnnotationAssertion(rdfs:label "postsynaptic cytoskeleton organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vesicle fusion to plasma membrane) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "ISBN:0071120009") Annotation( "PMID:18618940") "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space.") AnnotationAssertion(rdfs:label "vesicle fusion to plasma membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (exocytic vesicle membrane) +AnnotationAssertion(Annotation( "GOC:dos") "The lipid bilayer surrounding an exocytic vesicle.") AnnotationAssertion(rdfs:label "exocytic vesicle membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (secretory vesicle) +AnnotationAssertion(Annotation( "GOC:dos") "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.") AnnotationAssertion(rdfs:label "secretory vesicle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (supramolecular fiber) +AnnotationAssertion(Annotation( "GOC:dos") "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.") AnnotationAssertion(rdfs:label "supramolecular fiber") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (polymeric cytoskeletal fiber) +AnnotationAssertion(Annotation( "GOC:dos") "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits.") AnnotationAssertion(rdfs:label "polymeric cytoskeletal fiber") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24897,21 +32779,25 @@ SubClassOf( ObjectSomeValuesFrom( (actin filament-based transport) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:tb") "The transport of organelles or other particles from one location in the cell to another along actin filaments.") AnnotationAssertion(rdfs:label "actin filament-based transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (vesicle cytoskeletal trafficking) +AnnotationAssertion(Annotation( "GOC:ecd") Annotation( "GOC:rl") "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins.") AnnotationAssertion(rdfs:label "vesicle cytoskeletal trafficking") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (presynaptic process involved in chemical synaptic transmission) +AnnotationAssertion(Annotation( "GOC:dos") "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.") AnnotationAssertion(rdfs:label "presynaptic process involved in chemical synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (synaptic signaling) +AnnotationAssertion(Annotation( "GOC:dos") "Cell-cell signaling to, from or within a synapse.") AnnotationAssertion(rdfs:label "synaptic signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -24920,26 +32806,41 @@ SubClassOf( ObjectAllValuesFrom( (trans-synaptic signaling) +AnnotationAssertion(Annotation( "GOC:dos") "Cell-cell signaling in either direction across the synaptic cleft.") AnnotationAssertion(rdfs:label "trans-synaptic signaling") SubClassOf( ) # Class: (synaptic signaling via neuropeptide) +AnnotationAssertion(Annotation( "GOC:dos") "Cell-cell signaling to or from a synapse, mediated by a peptide.") AnnotationAssertion(rdfs:label "synaptic signaling via neuropeptide") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (trans-synaptic signaling by neuropeptide) +AnnotationAssertion(Annotation( "GOC:dos") "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.") AnnotationAssertion(rdfs:label "trans-synaptic signaling by neuropeptide") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (trans-synaptic signaling by lipid) +AnnotationAssertion(Annotation( "GOC:dos") "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid.") AnnotationAssertion(rdfs:label "trans-synaptic signaling by lipid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (protein catabolic process, modulating synaptic transmission) + +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:23083742") "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") +AnnotationAssertion(rdfs:label "protein catabolic process, modulating synaptic transmission") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) + # Class: (regulation of translation at synapse, modulating synaptic transmission) +AnnotationAssertion(Annotation( "GOC:dos") "Any process that modulates synaptic transmission by regulating translation occurring at the synapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "regulation of translation at synapse, modulating synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -24947,60 +32848,101 @@ SubClassOf( ObjectAllValuesFrom( (trans-synaptic signaling, modulating synaptic transmission) +AnnotationAssertion(Annotation( "GOC:dos") "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "trans-synaptic signaling, modulating synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (trans-synaptic signaling by neuropeptide, modulating synaptic transmission) +AnnotationAssertion(Annotation( "GOC:dos") "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "trans-synaptic signaling by neuropeptide, modulating synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (trans-synaptic signaling by lipid, modulating synaptic transmission) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:21531987") "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "trans-synaptic signaling by lipid, modulating synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (cytoplasmic region) +AnnotationAssertion(Annotation( "GOC:dos") "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm.") AnnotationAssertion(rdfs:label "cytoplasmic region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (presynaptic cytoskeleton) +AnnotationAssertion(Annotation( "GOC:dos") "The portion of the cytoskeleton contained within the presynapse.") AnnotationAssertion(rdfs:label "presynaptic cytoskeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (postsynaptic cytoskeleton) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:19889835") "The portion of the cytoskeleton contained within the postsynapse.") AnnotationAssertion(rdfs:label "postsynaptic cytoskeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (regulation of protein catabolic process at synapse, modulating synaptic transmission) + +AnnotationAssertion(Annotation( "GOC:dos") "Any process that modulates synaptic transmission by regulating protein degradation at the synapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") +AnnotationAssertion(rdfs:label "regulation of protein catabolic process at synapse, modulating synaptic transmission") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) + +# Class: (regulation of protein catabolic process at presynapse, modulating synaptic transmission) + +AnnotationAssertion(Annotation( "GOC:dos") "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") +AnnotationAssertion(rdfs:label "regulation of protein catabolic process at presynapse, modulating synaptic transmission") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (regulation of protein catabolic process at postsynapse, modulating synaptic transmission) + +AnnotationAssertion(Annotation( "GOC:dos") "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") +AnnotationAssertion(rdfs:label "regulation of protein catabolic process at postsynapse, modulating synaptic transmission") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (regulation of translation at presynapse, modulating synaptic transmission) +AnnotationAssertion(Annotation( "GOC:dos") "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "regulation of translation at presynapse, modulating synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (regulation of translation at postsynapse, modulating synaptic transmission) +AnnotationAssertion(Annotation( "GOC:dos") "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "regulation of translation at postsynapse, modulating synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (protein transport within plasma membrane) +AnnotationAssertion(Annotation( "GOC:dos") "A process in which protein is transported from one region of the plasma membrane to another.") AnnotationAssertion(rdfs:label "protein transport within plasma membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (axo-dendritic protein transport) +AnnotationAssertion(Annotation( "ISBN:0815316194") "The directed movement of proteins along microtubules in neuron projections.") AnnotationAssertion(rdfs:label "axo-dendritic protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (signal release from synapse) +AnnotationAssertion(Annotation( "GOC:dos") "Any signal release from a synapse.") AnnotationAssertion(rdfs:label "signal release from synapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -25010,22 +32952,27 @@ SubClassOf( ObjectAllValuesFrom( (cell cortex region) +AnnotationAssertion(Annotation( "GOC:dos") "The complete extent of cell cortex that underlies some some region of the plasma membrane.") AnnotationAssertion(rdfs:label "cell cortex region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of skeletal muscle contraction by action potential) +AnnotationAssertion(Annotation( "GOC:cjm") Annotation( "GOC:obol") "Any action potential process that regulates skeletal muscle contraction.") AnnotationAssertion(rdfs:label "regulation of skeletal muscle contraction by action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (vascular endothelial cell proliferation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_telomere") Annotation( "GOC:nc") Annotation( "PMID:23201774") "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population.") AnnotationAssertion(rdfs:label "vascular endothelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mitotic nuclear membrane organization) +AnnotationAssertion(Annotation( "GOC:vw") Annotation( "PMID:15147872") "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis.") +AnnotationAssertion(rdfs:comment "This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown.") AnnotationAssertion(rdfs:label "mitotic nuclear membrane organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -25033,6 +32980,7 @@ SubClassOf( ObjectAllValuesFrom( (nuclear membrane biogenesis) +AnnotationAssertion(Annotation( "GOC:vw") "The process in which a nuclear membrane is synthesized, aggregates, and bonds together.") AnnotationAssertion(rdfs:label "nuclear membrane biogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -25040,57 +32988,68 @@ SubClassOf( ObjectSomeValuesFrom( (neuron projection organization) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:11585923") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite.") AnnotationAssertion(rdfs:label "neuron projection organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of vesicle fusion with Golgi apparatus) +AnnotationAssertion(Annotation( "GOC:se") Annotation( "PMID:26195667") "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus.") AnnotationAssertion(rdfs:label "regulation of vesicle fusion with Golgi apparatus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of vesicle fusion with Golgi apparatus) +AnnotationAssertion(Annotation( "GOC:se") Annotation( "PMID:26195667") "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus.") AnnotationAssertion(rdfs:label "negative regulation of vesicle fusion with Golgi apparatus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of vesicle fusion with Golgi apparatus) +AnnotationAssertion(Annotation( "GOC:se") Annotation( "PMID:26195667") "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus.") AnnotationAssertion(rdfs:label "positive regulation of vesicle fusion with Golgi apparatus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of basement membrane organization) +AnnotationAssertion(Annotation( "GOC:ha") Annotation( "PMID:27404358") "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane.") AnnotationAssertion(rdfs:label "regulation of basement membrane organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of actomyosin structure organization) +AnnotationAssertion(Annotation( "GOC:lf") Annotation( "PMID:22790195") "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin.") AnnotationAssertion(rdfs:label "regulation of actomyosin structure organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cardiac muscle myoblast proliferation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:26512644") "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.") AnnotationAssertion(rdfs:label "cardiac muscle myoblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cardiac muscle myoblast proliferation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:26512644") "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle myoblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac muscle myoblast proliferation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:26512644") "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation.") AnnotationAssertion(rdfs:label "negative regulation of cardiac muscle myoblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardiac muscle myoblast proliferation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:26512644") "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation.") AnnotationAssertion(rdfs:label "positive regulation of cardiac muscle myoblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of actin filament organization) +AnnotationAssertion(Annotation( "GOC:kmv") "Any process that modulates the frequency, rate or extent of actin filament organization.") AnnotationAssertion(rdfs:label "regulation of actin filament organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -25098,233 +33057,357 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of blood vessel endothelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:23072816") "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation.") AnnotationAssertion(rdfs:label "regulation of blood vessel endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of blood vessel endothelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:23072816") "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of blood vessel endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of blood vessel endothelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:23072816") "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of blood vessel endothelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (vesicle-mediated intercellular transport) +AnnotationAssertion(Annotation( "GOC:sp") Annotation( "PMID:29328915") Annotation( "PMID:29328916") "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane.") AnnotationAssertion(rdfs:label "vesicle-mediated intercellular transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of animal organ morphogenesis) +AnnotationAssertion(Annotation( "GOC:kmv") "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis.") AnnotationAssertion(rdfs:label "positive regulation of animal organ morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of animal organ morphogenesis) +AnnotationAssertion(Annotation( "GOC:kmv") "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of animal organ morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (regulation of lipid transporter activity) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:27365390") "Any process that modulates the frequency, rate, or extent of lipid transporter activity.") +AnnotationAssertion(rdfs:label "regulation of lipid transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (positive regulation of lipid transporter activity) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:27365390") "Any process that increases the frequency, rate, or extent of lipid transporter activity.") +AnnotationAssertion(rdfs:label "positive regulation of lipid transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (negative regulation of lipid transporter activity) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:27365390") "Any process that decreases the frequency, rate, or extent of lipid transporter activity.") +AnnotationAssertion(rdfs:label "negative regulation of lipid transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (regulation of compound eye photoreceptor cell differentiation) +AnnotationAssertion(Annotation( "GOC:ha") Annotation( "PMID:16377567") "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation.") AnnotationAssertion(rdfs:label "regulation of compound eye photoreceptor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of compound eye photoreceptor cell differentiation) +AnnotationAssertion(Annotation( "GOC:ha") Annotation( "PMID:16377567") "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of compound eye photoreceptor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of compound eye photoreceptor cell differentiation) +AnnotationAssertion(Annotation( "GOC:ha") Annotation( "PMID:16377567") "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of compound eye photoreceptor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (myotube cell migration) +AnnotationAssertion(Annotation( "GOC:ha") Annotation( "PMID:29122742") "The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse.") AnnotationAssertion(rdfs:label "myotube cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of myotube cell migration) +AnnotationAssertion(Annotation( "GOC:ha") Annotation( "PMID:29122742") "Any process that modulates the frequency, rate or extent of myotube cell migration.") AnnotationAssertion(rdfs:label "regulation of myotube cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myotube cell migration) +AnnotationAssertion(Annotation( "GOC:ha") Annotation( "PMID:29122742") "Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration.") AnnotationAssertion(rdfs:label "positive regulation of myotube cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myotube cell migration) +AnnotationAssertion(Annotation( "GOC:ha") Annotation( "PMID:29122742") "Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration.") AnnotationAssertion(rdfs:label "negative regulation of myotube cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular anatomical entity) +AnnotationAssertion(Annotation( "GOC:kmv") "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.") AnnotationAssertion(rdfs:label "cellular anatomical entity") SubClassOf( ) SubClassOf( ) # Class: (plasma membrane bounded cell projection) +AnnotationAssertion(Annotation( "GOC:krc") "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.") AnnotationAssertion(rdfs:label "plasma membrane bounded cell projection") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (plasma membrane bounded cell projection assembly) +AnnotationAssertion(Annotation( "GOC:krc") "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.") AnnotationAssertion(rdfs:label "plasma membrane bounded cell projection assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of plasma membrane bounded cell projection assembly) +AnnotationAssertion(Annotation( "GOC:krc") "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly.") AnnotationAssertion(rdfs:label "regulation of plasma membrane bounded cell projection assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of plasma membrane bounded cell projection assembly) +AnnotationAssertion(Annotation( "GOC:krc") "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly.") AnnotationAssertion(rdfs:label "negative regulation of plasma membrane bounded cell projection assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of plasma membrane bounded cell projection assembly) +AnnotationAssertion(Annotation( "GOC:krc") "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly.") AnnotationAssertion(rdfs:label "positive regulation of plasma membrane bounded cell projection assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of plasma membrane bounded cell projection organization) +AnnotationAssertion(Annotation( "GOC:krc") "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.") AnnotationAssertion(rdfs:label "regulation of plasma membrane bounded cell projection organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (plasma membrane bounded cell projection organization) +AnnotationAssertion(Annotation( "GOC:krc") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon.") AnnotationAssertion(rdfs:label "plasma membrane bounded cell projection organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (plasma membrane bounded cell projection morphogenesis) +AnnotationAssertion(Annotation( "GOC:krc") "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized.") AnnotationAssertion(rdfs:label "plasma membrane bounded cell projection morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (neuron projection cytoplasm) +AnnotationAssertion(Annotation( "GOC:ha") "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection.") AnnotationAssertion(rdfs:label "neuron projection cytoplasm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (positive regulation of collagen catabolic process) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.") +AnnotationAssertion(rdfs:label "positive regulation of collagen catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (steroid hormone biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:krc") Annotation( "GOC:nln") "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.") +AnnotationAssertion(rdfs:label "steroid hormone biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (negative regulation of protein localization to chromatin) +AnnotationAssertion(Annotation( "PMID:20889714") Annotation( "PMID:29899453") "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to chromatin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to chromatin) +AnnotationAssertion(Annotation( "PMID:20889714") Annotation( "PMID:29899453") "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to chromatin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of bile acid secretion) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:22767443") "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.") +AnnotationAssertion(rdfs:label "regulation of bile acid secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of bile acid secretion) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:22767443") "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.") +AnnotationAssertion(rdfs:label "positive regulation of bile acid secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of bile acid secretion) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:rph") Annotation( "PMID:22767443") "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.") +AnnotationAssertion(rdfs:label "negative regulation of bile acid secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of blastocyst development) +AnnotationAssertion(Annotation( "GOC:krc") Annotation( "PMID:29593216") "Any process that modulates the frequency, rate or extent of blastocyst development.") AnnotationAssertion(rdfs:label "regulation of blastocyst development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to motile cilium) +AnnotationAssertion(Annotation( "GOC:krc") Annotation( "PMID:27486780") "A process in which a protein is transported to, or maintained in, a location within a motile cilium.") AnnotationAssertion(rdfs:label "protein localization to motile cilium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of pigmentation) +AnnotationAssertion(Annotation( "GOC:krc") "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism.") AnnotationAssertion(rdfs:label "regulation of pigmentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (endothelial tube formation) +AnnotationAssertion(Annotation( "GOC:sl") Annotation( "PMID:23239824") "The developmental process pertaining to the initial formation of an endothelial tube.") AnnotationAssertion(rdfs:label "endothelial tube formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (meiotic nuclear division) +AnnotationAssertion(Annotation( "PMID:9334324") "One of the two nuclear divisions that occur as part of the meiotic cell cycle.") AnnotationAssertion(rdfs:label "meiotic nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mitotic nuclear division) +AnnotationAssertion(Annotation( "ISBN:0198547684") "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.") AnnotationAssertion(rdfs:label "mitotic nuclear division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (exocytic process) +AnnotationAssertion(Annotation( "Wikipedia:Exocytosis") "The cellular processes that contribute to exocytosis.") AnnotationAssertion(rdfs:label "exocytic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell-cell adhesion in response to extracellular stimulus) +AnnotationAssertion(Annotation( "PMID:14996911") "The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus.") AnnotationAssertion(rdfs:label "cell-cell adhesion in response to extracellular stimulus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (organelle localization by membrane tethering) +AnnotationAssertion(Annotation( "PMID:27875684") "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other.") AnnotationAssertion(rdfs:label "organelle localization by membrane tethering") SubClassOf( ) SubClassOf( ) # Class: (regulation of lipoprotein transport) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:RPH") Annotation( "PMID:26501192") "Any process that controls lipoprotein transport.") AnnotationAssertion(rdfs:label "regulation of lipoprotein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of lipoprotein transport) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:RPH") Annotation( "PMID:26501192") "Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport.") AnnotationAssertion(rdfs:label "negative regulation of lipoprotein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of lipoprotein transport) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:RPH") Annotation( "PMID:26501192") "Any process that activates or increases the rate or extent of lipoprotein transport.") AnnotationAssertion(rdfs:label "positive regulation of lipoprotein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (catalytic activity, acting on a protein) + +AnnotationAssertion(Annotation( "GOC:molecular_function_refactoring") Annotation( "GOC:pdt") "Catalytic activity that acts to modify a protein.") +AnnotationAssertion(rdfs:label "catalytic activity, acting on a protein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (catalytic activity, acting on DNA) + +AnnotationAssertion(Annotation( "GOC:molecular_function_refactoring") Annotation( "GOC:pdt") "Catalytic activity that acts to modify DNA.") +AnnotationAssertion(rdfs:label "catalytic activity, acting on DNA") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (catalytic activity, acting on RNA) + +AnnotationAssertion(Annotation( "GOC:molecular_function_refactoring") Annotation( "GOC:pdt") "Catalytic activity that acts to modify RNA, driven by ATP hydrolysis.") +AnnotationAssertion(rdfs:label "catalytic activity, acting on RNA") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (catalytic activity, acting on a glycoprotein) + +AnnotationAssertion(Annotation( "GOC:molecular_function_refactoring") Annotation( "GOC:pdt") "Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein.") +AnnotationAssertion(rdfs:label "catalytic activity, acting on a glycoprotein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (extracellular vesicle biogenesis) +AnnotationAssertion(Annotation( "PMID:28736435") "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.") AnnotationAssertion(rdfs:label "extracellular vesicle biogenesis") SubClassOf( ) # Class: (positive regulation of lymphocyte chemotaxis) +AnnotationAssertion(Annotation( "PMID:19255442") "Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis.") AnnotationAssertion(rdfs:label "positive regulation of lymphocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (translation at presynapse) +AnnotationAssertion(Annotation( "PMID:27321671") "Translation that occurs at the presynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "translation at presynapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (translation at presynapse, modulating chemical synaptic transmission) +AnnotationAssertion(Annotation( "PMID:27321671") "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "translation at presynapse, modulating chemical synaptic transmission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (presynaptic endocytosis) +AnnotationAssertion(Annotation( "PMID:24719103") "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "presynaptic endocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (postsynaptic endocytosis) +AnnotationAssertion(Annotation( "PMID:12839988") "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "postsynaptic endocytosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (translation at synapse) +AnnotationAssertion(Annotation( "PMID:23083742") "Translation that occurs at the synapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "translation at synapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -25332,11 +33415,15 @@ SubClassOf( ObjectAllValuesFrom( (translation at postsynapse) +AnnotationAssertion(Annotation( "PMID:20427644") "Translation that occurs at the postsynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "translation at postsynapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of translation at synapse) +AnnotationAssertion(Annotation( "PMID:20427644") "Any process that regulates translation occurring at the synapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "regulation of translation at synapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -25344,85 +33431,171 @@ SubClassOf( ObjectAllValuesFrom( (regulation of translation at presynapse) +AnnotationAssertion(Annotation( "PMID:20427644") "Any process that regulates translation occurring at the presynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "regulation of translation at presynapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (regulation of translation at postsynapse) +AnnotationAssertion(Annotation( "PMID:20427644") "Any process that regulates translation occurring at the postsynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") AnnotationAssertion(rdfs:label "regulation of translation at postsynapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +# Class: (protein catabolic process at synapse) + +AnnotationAssertion(Annotation( "PMID:17062563") "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") +AnnotationAssertion(rdfs:label "protein catabolic process at synapse") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) + +# Class: (protein catabolic process at presynapse) + +AnnotationAssertion(Annotation( "PMID:27764673") "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") +AnnotationAssertion(rdfs:label "protein catabolic process at presynapse") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) + +# Class: (protein catabolic process at postsynapse) + +AnnotationAssertion(Annotation( "PMID:17062563") "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") +AnnotationAssertion(rdfs:label "protein catabolic process at postsynapse") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) + +# Class: (regulation protein catabolic process at synapse) + +AnnotationAssertion(Annotation( "PMID:23083742") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") +AnnotationAssertion(rdfs:label "regulation protein catabolic process at synapse") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) + +# Class: (regulation protein catabolic process at presynapse) + +AnnotationAssertion(Annotation( "PMID:27764673") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") +AnnotationAssertion(rdfs:label "regulation protein catabolic process at presynapse") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) + +# Class: (regulation protein catabolic process at postsynapse) + +AnnotationAssertion(Annotation( "PMID:17062563") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.") +AnnotationAssertion(rdfs:comment "Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.") +AnnotationAssertion(rdfs:label "regulation protein catabolic process at postsynapse") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) + # Class: (cell-cell fusion) +AnnotationAssertion(Annotation( "Wikipedia:Cell_fusion") "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.") AnnotationAssertion(rdfs:label "cell-cell fusion") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (protein transporter activity) + +AnnotationAssertion(Annotation( "PMID:18706423") "Directly binding to a specific protein and delivering it to a specific cellular location.") +AnnotationAssertion(Annotation(rdfs:label "M6PR transports activated ARSA to the lysosome") "Reactome:R-HSA-2248891") +AnnotationAssertion(Annotation(rdfs:label "iRHOM2 transports ADAM17 from ER to the Golgi-network") "Reactome:R-HSA-9662747") +AnnotationAssertion(Annotation(rdfs:label "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane") "Reactome:R-HSA-9662818") +AnnotationAssertion(rdfs:comment "Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation.") +AnnotationAssertion(rdfs:label "protein transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (export from cell) +AnnotationAssertion(Annotation( "GOC:pg") "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis.") AnnotationAssertion(rdfs:label "export from cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (lipid export from cell) +AnnotationAssertion(Annotation( "GOC:pg") "The directed movement of a lipid from a cell, into the extracellular region.") AnnotationAssertion(rdfs:label "lipid export from cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (lipid import into cell) +AnnotationAssertion(Annotation( "GOC:pg") "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.") AnnotationAssertion(rdfs:label "lipid import into cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (nuclear protein-containing complex) +AnnotationAssertion(Annotation( "GOC:pg") "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.") AnnotationAssertion(rdfs:label "nuclear protein-containing complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (vacuole fission) +AnnotationAssertion(Annotation( "PMID:19643199") "The division of a vacuole within a cell to form two or more separate vacuoles.") AnnotationAssertion(rdfs:label "vacuole fission") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (non-membrane-bounded organelle assembly) +AnnotationAssertion(Annotation( "PMID:28225081") "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.") AnnotationAssertion(rdfs:label "non-membrane-bounded organelle assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (ammonium excretion) + +AnnotationAssertion(Annotation( "PMID:25740900") "The elimination of ammonium ions from an excretory cell.") +AnnotationAssertion(rdfs:label "ammonium excretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (multicellular organismal-level chemical homeostasis) + +AnnotationAssertion(Annotation( "GOC:curators") "A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.") +AnnotationAssertion(rdfs:label "multicellular organismal-level chemical homeostasis") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of protein localization to lysosome) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:24305806") "Any process that modulates the frequency, rate or extent of protein localization to lysosome.") AnnotationAssertion(rdfs:label "regulation of protein localization to lysosome") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to lysosome) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") "Any process that activates or increases the frequency, rate or extent of protein localization to lysosome.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to lysosome") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to lysosome) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:24305806") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to lysosome") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of postsynapse assembly) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:16394100") Annotation( "PMID:16672654") Annotation( "PMID:28185854") "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.") AnnotationAssertion(rdfs:label "regulation of postsynapse assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (visual system development) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "GOC:krc") Annotation( "PMID:15004427") Annotation( "PMID:20647017") Annotation( "PMID:22632727") "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways.") AnnotationAssertion(rdfs:label "visual system development") SubClassOf( ) # Class: (neuroinflammatory response) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:10981966") Annotation( "PMID:11099416") Annotation( "PMID:18164423") "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents.") AnnotationAssertion(rdfs:label "neuroinflammatory response") SubClassOf( ) # Class: (regulation of neuroinflammatory response) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:10981966") Annotation( "PMID:11099416") Annotation( "PMID:18164423") "Any process that modulates the frequency, rate or extent of neuroinflammatory response.") AnnotationAssertion(rdfs:label "regulation of neuroinflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -25430,218 +33603,308 @@ SubClassOf( ObjectAllValuesFrom( (positive regulation of neuroinflammatory response) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response.") AnnotationAssertion(rdfs:label "positive regulation of neuroinflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of neuroinflammatory response) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:11099416") Annotation( "PMID:18164423") "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.") AnnotationAssertion(rdfs:label "negative regulation of neuroinflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (glial cell-neuron signaling) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:14980203") Annotation( "PMID:16144764") Annotation( "PMID:16547515") Annotation( "PMID:18685038") Annotation( "PMID:27788368") Annotation( "PMID:9459440") "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum.") AnnotationAssertion(rdfs:label "glial cell-neuron signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (neuron-glial cell signaling) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:10195197") Annotation( "PMID:10196584") Annotation( "PMID:10377338") Annotation( "PMID:10493741") Annotation( "PMID:11356870") Annotation( "PMID:11399439") Annotation( "PMID:15252819") Annotation( "PMID:27788368") "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine.") AnnotationAssertion(rdfs:label "neuron-glial cell signaling") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (negative regulation of monocyte activation) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "PMID:15597323") "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation.") AnnotationAssertion(rdfs:label "negative regulation of monocyte activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to cell-cell junction) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:26706435") "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction.") AnnotationAssertion(rdfs:label "protein localization to cell-cell junction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of protein localization to cell-cell junction) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:26706435") "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction.") AnnotationAssertion(rdfs:label "regulation of protein localization to cell-cell junction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to cell-cell junction) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:26706435") "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to cell-cell junction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of transepithelial transport) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "PMID:27593915") "Any process that modulates the frequency, rate or extent of transepithelial transport.") AnnotationAssertion(rdfs:label "regulation of transepithelial transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to cell-cell junction) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to cell-cell junction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell junction disassembly) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "PMID:25490267") "The disaggregation of a cell junction into its constituent components.") AnnotationAssertion(rdfs:label "cell junction disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell-cell junction disassembly) +AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "PMID:25490267") "The disaggregation of a cell-cell junction into its constituent components.") AnnotationAssertion(rdfs:label "cell-cell junction disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (somatic sensory system development) +AnnotationAssertion(Annotation( "PMID:25832476") Annotation( "PMID:31399790") "The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain.") AnnotationAssertion(rdfs:label "somatic sensory system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (chordate pharynx development) +AnnotationAssertion(Annotation( "PMID:23020903") "The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "chordate pharynx development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (lipid transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:curators") "Enables the transfer of a lipid from one side of a membrane to the other.") +AnnotationAssertion(rdfs:label "lipid transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of cytokine production involved in inflammatory response) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.") AnnotationAssertion(rdfs:label "regulation of cytokine production involved in inflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cytokine production involved in inflammatory response) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.") AnnotationAssertion(rdfs:label "negative regulation of cytokine production involved in inflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cytokine production involved in inflammatory response) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.") AnnotationAssertion(rdfs:label "positive regulation of cytokine production involved in inflammatory response") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of cellular response to insulin stimulus) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:yaf") "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus.") +AnnotationAssertion(rdfs:label "regulation of cellular response to insulin stimulus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of cellular response to insulin stimulus) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:yaf") "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus.") +AnnotationAssertion(rdfs:label "negative regulation of cellular response to insulin stimulus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of cellular response to insulin stimulus) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:yaf") "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus.") +AnnotationAssertion(rdfs:label "positive regulation of cellular response to insulin stimulus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (extracellular regulation of signal transduction) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:signaling") "Any regulation of signal transduction that takes place in the extracellular region.") AnnotationAssertion(rdfs:label "extracellular regulation of signal transduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (extracellular negative regulation of signal transduction) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:signaling") "Any negative regulation of signal transduction that takes place in extracellular region.") AnnotationAssertion(rdfs:label "extracellular negative regulation of signal transduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of execution phase of apoptosis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") "Any process that modulates the frequency, rate or extent of execution phase of apoptosis.") AnnotationAssertion(rdfs:label "regulation of execution phase of apoptosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of execution phase of apoptosis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.") AnnotationAssertion(rdfs:label "negative regulation of execution phase of apoptosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of execution phase of apoptosis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.") AnnotationAssertion(rdfs:label "positive regulation of execution phase of apoptosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of hyaluronan biosynthetic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:yaf") "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process.") AnnotationAssertion(rdfs:label "regulation of hyaluronan biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of hyaluronan biosynthetic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:yaf") "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process.") AnnotationAssertion(rdfs:label "negative regulation of hyaluronan biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of hyaluronan biosynthetic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:yaf") "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process.") AnnotationAssertion(rdfs:label "positive regulation of hyaluronan biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of defense response to fungus) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dhl") Annotation( "PMID:22242006") "Any process that modulates the frequency, rate or extent of defense response to fungus.") AnnotationAssertion(rdfs:label "regulation of defense response to fungus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of protein localization to nucleus) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of protein localization to nucleus.") AnnotationAssertion(rdfs:label "regulation of protein localization to nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to nucleus) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to nucleus) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of oocyte maturation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:kmv") "Any process that modulates the frequency, rate or extent of oocyte maturation.") AnnotationAssertion(rdfs:label "regulation of oocyte maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of oocyte maturation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:kmv") "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.") AnnotationAssertion(rdfs:label "negative regulation of oocyte maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of oocyte maturation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:kmv") "Any process that activates or increases the frequency, rate or extent of oocyte maturation.") AnnotationAssertion(rdfs:label "positive regulation of oocyte maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of defense response to insect) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:22474183") "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect.") AnnotationAssertion(rdfs:label "negative regulation of defense response to insect") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of defense response to insect) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:22474183") "Any process that activates or increases the frequency, rate or extent of defense response to insect.") AnnotationAssertion(rdfs:label "positive regulation of defense response to insect") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of defense response to bacterium) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:22346749") "Any process that modulates the frequency, rate or extent of defense response to bacterium.") AnnotationAssertion(rdfs:label "regulation of defense response to bacterium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of defense response to bacterium) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:22346749") "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.") AnnotationAssertion(rdfs:label "negative regulation of defense response to bacterium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of defense response to bacterium) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:22346749") "Any process that activates or increases the frequency, rate or extent of defense response to bacterium.") AnnotationAssertion(rdfs:label "positive regulation of defense response to bacterium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (insulin metabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") "The chemical reactions and pathways involving insulin.") +AnnotationAssertion(rdfs:label "insulin metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( ObjectComplementOf())) +DisjointClasses( ObjectSomeValuesFrom( )) + +# Class: (insulin catabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") "The chemical reactions and pathways resulting in the breakdown of insulin.") +AnnotationAssertion(rdfs:label "insulin catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (gene expression involved in extracellular matrix organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pg") Annotation( "PMID:18668558") "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form.") AnnotationAssertion(rdfs:label "gene expression involved in extracellular matrix organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (primary amino compound metabolic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") "The chemical reactions and pathways involving primary amino compound.") AnnotationAssertion(rdfs:label "primary amino compound metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (primary amino compound catabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") "The chemical reactions and pathways resulting in the breakdown of primary amino compound.") +AnnotationAssertion(rdfs:label "primary amino compound catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (primary amino compound biosynthetic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") "The chemical reactions and pathways resulting in the formation of primary amino compound.") AnnotationAssertion(rdfs:label "primary amino compound biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of trophoblast cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of trophoblast cell migration.") AnnotationAssertion(rdfs:label "regulation of trophoblast cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of trophoblast cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.") AnnotationAssertion(rdfs:label "negative regulation of trophoblast cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -25649,6 +33912,7 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of trophoblast cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration.") AnnotationAssertion(rdfs:label "positive regulation of trophoblast cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -25657,99 +33921,117 @@ SubClassOf( ObjectSomeValuesFrom( (neural crest cell migration involved in autonomic nervous system development) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any neural crest cell migration that is involved in autonomic nervous system development.") AnnotationAssertion(rdfs:label "neural crest cell migration involved in autonomic nervous system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of formation of translation initiation ternary complex) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex.") AnnotationAssertion(rdfs:label "regulation of formation of translation initiation ternary complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of formation of translation initiation ternary complex) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex.") AnnotationAssertion(rdfs:label "negative regulation of formation of translation initiation ternary complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of formation of translation initiation ternary complex) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex.") AnnotationAssertion(rdfs:label "positive regulation of formation of translation initiation ternary complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of extracellular matrix assembly) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of extracellular matrix assembly.") AnnotationAssertion(rdfs:label "regulation of extracellular matrix assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of extracellular matrix assembly) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly.") AnnotationAssertion(rdfs:label "negative regulation of extracellular matrix assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of extracellular matrix assembly) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly.") AnnotationAssertion(rdfs:label "positive regulation of extracellular matrix assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of cardiac chamber formation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of cardiac chamber formation.") AnnotationAssertion(rdfs:label "regulation of cardiac chamber formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac chamber formation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation.") AnnotationAssertion(rdfs:label "negative regulation of cardiac chamber formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardiac chamber formation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation.") AnnotationAssertion(rdfs:label "positive regulation of cardiac chamber formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of cardiac chamber morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis.") AnnotationAssertion(rdfs:label "regulation of cardiac chamber morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of cardiac chamber morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of cardiac chamber morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardiac chamber morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis.") AnnotationAssertion(rdfs:label "positive regulation of cardiac chamber morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of lung ciliated cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation.") AnnotationAssertion(rdfs:label "regulation of lung ciliated cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of lung ciliated cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of lung ciliated cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of lung ciliated cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of lung ciliated cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of vasculature development) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of vasculature development.") AnnotationAssertion(rdfs:label "regulation of vasculature development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of vasculature development) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.") AnnotationAssertion(rdfs:label "negative regulation of vasculature development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -25758,188 +34040,256 @@ SubClassOf( (regulation of endothelial tube morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis.") AnnotationAssertion(rdfs:label "regulation of endothelial tube morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of hematopoietic progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation.") AnnotationAssertion(rdfs:label "regulation of hematopoietic progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of hematopoietic progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of hematopoietic progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of hematopoietic progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of hematopoietic progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of endothelial cell development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") Annotation( "PMID:19470579") "Any process that modulates the frequency, rate or extent of endothelial cell development.") AnnotationAssertion(rdfs:label "regulation of endothelial cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of endothelial cell development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") Annotation( "PMID:19470579") "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development.") AnnotationAssertion(rdfs:label "negative regulation of endothelial cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of endothelial cell development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") Annotation( "PMID:19470579") "Any process that activates or increases the frequency, rate or extent of endothelial cell development.") AnnotationAssertion(rdfs:label "positive regulation of endothelial cell development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (organonitrogen compound metabolic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "The chemical reactions and pathways involving organonitrogen compound.") AnnotationAssertion(rdfs:label "organonitrogen compound metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (organonitrogen compound catabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "The chemical reactions and pathways resulting in the breakdown of organonitrogen compound.") +AnnotationAssertion(rdfs:label "organonitrogen compound catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (organonitrogen compound biosynthetic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "The chemical reactions and pathways resulting in the formation of organonitrogen compound.") AnnotationAssertion(rdfs:label "organonitrogen compound biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of vesicle transport along microtubule) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule.") AnnotationAssertion(rdfs:label "regulation of vesicle transport along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of vesicle transport along microtubule) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule.") AnnotationAssertion(rdfs:label "negative regulation of vesicle transport along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of vesicle transport along microtubule) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule.") AnnotationAssertion(rdfs:label "positive regulation of vesicle transport along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (organic hydroxy compound metabolic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "The chemical reactions and pathways involving organic hydroxy compound.") AnnotationAssertion(rdfs:label "organic hydroxy compound metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (organic hydroxy compound catabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound.") +AnnotationAssertion(rdfs:label "organic hydroxy compound catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (organic hydroxy compound biosynthetic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "The chemical reactions and pathways resulting in the formation of organic hydroxy compound.") AnnotationAssertion(rdfs:label "organic hydroxy compound biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (organic hydroxy compound transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "Enables the transfer of organic hydroxy compound from one side of a membrane to the other.") +AnnotationAssertion(rdfs:label "organic hydroxy compound transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of lymphocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis.") AnnotationAssertion(rdfs:label "regulation of lymphocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of lymphocyte chemotaxis) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis.") AnnotationAssertion(rdfs:label "negative regulation of lymphocyte chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (response to peptide) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.") AnnotationAssertion(rdfs:label "response to peptide") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular response to peptide) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.") AnnotationAssertion(rdfs:label "cellular response to peptide") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (response to ketone) + +AnnotationAssertion(Annotation( "GOC:mengo_curators") Annotation( "PMID:23356676") "A response that results in a state of tolerance to ketone.") +AnnotationAssertion(rdfs:label "response to ketone") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (cellular response to ketone) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus.") +AnnotationAssertion(rdfs:label "cellular response to ketone") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of compound eye retinal cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:12021768") "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process.") AnnotationAssertion(rdfs:label "regulation of compound eye retinal cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of compound eye retinal cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:12021768") "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of compound eye retinal cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of compound eye retinal cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:12021768") "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of compound eye retinal cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (response to nitrogen compound) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "response to nitrogen compound") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular response to nitrogen compound) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.") +AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") AnnotationAssertion(rdfs:label "cellular response to nitrogen compound") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mesenchymal cell differentiation involved in bone development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:hjd") Annotation( "PMID:21571217") "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state.") AnnotationAssertion(rdfs:label "mesenchymal cell differentiation involved in bone development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of muscle tissue development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:yaf") Annotation( "PMID:23150719") "Any process that modulates the frequency, rate or extent of muscle tissue development.") AnnotationAssertion(rdfs:label "regulation of muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of muscle tissue development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:yaf") Annotation( "PMID:23150719") "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development.") AnnotationAssertion(rdfs:label "negative regulation of muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of muscle tissue development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:yaf") Annotation( "PMID:23150719") "Any process that activates or increases the frequency, rate or extent of muscle tissue development.") AnnotationAssertion(rdfs:label "positive regulation of muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of protein depolymerization) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "PMID:12032137") "Any process that modulates the frequency, rate or extent of protein depolymerization.") AnnotationAssertion(rdfs:label "regulation of protein depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein depolymerization) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "PMID:12032137") "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization.") AnnotationAssertion(rdfs:label "negative regulation of protein depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein depolymerization) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "PMID:12032137") "Any process that activates or increases the frequency, rate or extent of protein depolymerization.") AnnotationAssertion(rdfs:label "positive regulation of protein depolymerization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cell junction assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of cell junction assembly.") AnnotationAssertion(rdfs:label "regulation of cell junction assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of cell junction assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly.") AnnotationAssertion(rdfs:label "negative regulation of cell junction assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cell junction assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of cell junction assembly.") AnnotationAssertion(rdfs:label "positive regulation of cell junction assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of cell proliferation involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") Annotation( "PMID:21419760") "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis.") AnnotationAssertion(rdfs:label "regulation of cell proliferation involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cell proliferation involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") Annotation( "PMID:21419760") "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis.") AnnotationAssertion(rdfs:label "positive regulation of cell proliferation involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cilium assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:dph") Annotation( "PMID:17719545") "Any process that modulates the frequency, rate or extent of cilium assembly.") AnnotationAssertion(rdfs:label "regulation of cilium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -25948,52 +34298,62 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (negative regulation of cilium assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:dph") Annotation( "PMID:17719545") "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.") AnnotationAssertion(rdfs:label "negative regulation of cilium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cilium-dependent cell motility) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility.") AnnotationAssertion(rdfs:label "regulation of cilium-dependent cell motility") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cilium-dependent cell motility) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:jl") "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility.") AnnotationAssertion(rdfs:label "negative regulation of cilium-dependent cell motility") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of hematopoietic stem cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:23403623") "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation.") AnnotationAssertion(rdfs:label "regulation of hematopoietic stem cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of hematopoietic stem cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:23403623") "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of hematopoietic stem cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of hematopoietic stem cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:23403623") "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of hematopoietic stem cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of hematopoietic stem cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:23403623") "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.") AnnotationAssertion(rdfs:label "regulation of hematopoietic stem cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of hematopoietic stem cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:23403623") "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of hematopoietic stem cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of hematopoietic stem cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:23403623") "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of hematopoietic stem cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of leukocyte differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:add") "Any process that modulates the frequency, rate or extent of leukocyte differentiation.") AnnotationAssertion(rdfs:label "regulation of leukocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26001,6 +34361,7 @@ SubClassOf( (negative regulation of leukocyte differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:add") "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.") AnnotationAssertion(rdfs:label "negative regulation of leukocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26009,6 +34370,7 @@ SubClassOf( (positive regulation of leukocyte differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:add") "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation.") AnnotationAssertion(rdfs:label "positive regulation of leukocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26017,23 +34379,27 @@ SubClassOf( (regulation of organelle assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "Any process that modulates the frequency, rate or extent of organelle assembly.") AnnotationAssertion(rdfs:label "regulation of organelle assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of organelle assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly.") AnnotationAssertion(rdfs:label "negative regulation of organelle assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of organelle assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") "Any process that activates or increases the frequency, rate or extent of organelle assembly.") AnnotationAssertion(rdfs:label "positive regulation of organelle assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (erythrocyte apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:rl") Annotation( "PMID:14569084") "Any apoptotic process in an erythrocyte.") AnnotationAssertion(rdfs:label "erythrocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -26042,11 +34408,13 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (regulation of erythrocyte apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:rl") Annotation( "PMID:14569084") "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process.") AnnotationAssertion(rdfs:label "regulation of erythrocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of erythrocyte apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:rl") Annotation( "PMID:14569084") "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of erythrocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -26055,6 +34423,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (positive regulation of erythrocyte apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:rl") Annotation( "PMID:14569084") "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of erythrocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -26063,112 +34432,186 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (regulation of apoptotic process involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:16839542") "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.") AnnotationAssertion(rdfs:label "regulation of apoptotic process involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of apoptotic process involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:16839542") "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of apoptotic process involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of apoptotic process involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:16839542") "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.") AnnotationAssertion(rdfs:label "positive regulation of apoptotic process involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (apoptotic process involved in blood vessel morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:16163358") "Any apoptotic process that is involved in blood vessel morphogenesis.") AnnotationAssertion(rdfs:label "apoptotic process involved in blood vessel morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of chromatin organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GOC:vw") Annotation( "GO_REF:0000058") Annotation( "PMID:18314879") "Any process that modulates the frequency, rate or extent of chromatin organization.") AnnotationAssertion(rdfs:label "regulation of chromatin organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of apoptotic process involved in morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:sart") Annotation( "PMID:12202035") "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis.") AnnotationAssertion(rdfs:label "regulation of apoptotic process involved in morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of apoptotic process involved in morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:sart") Annotation( "PMID:12202035") "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of apoptotic process involved in morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of apoptotic process involved in morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:sart") Annotation( "PMID:12202035") "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis.") AnnotationAssertion(rdfs:label "positive regulation of apoptotic process involved in morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of chromosome condensation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:23219725") "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation.") AnnotationAssertion(rdfs:label "negative regulation of chromosome condensation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (negative regulation of RNA catabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "PMID:16640457") "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process.") +AnnotationAssertion(rdfs:label "negative regulation of RNA catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (protein localization to cell junction) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:18332111") "A process in which a protein is transported to, or maintained in, a location within a cell junction.") AnnotationAssertion(rdfs:label "protein localization to cell junction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to cell leading edge) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:lb") Annotation( "PMID:21543326") "A process in which a protein is transported to, or maintained in, a location within a cell leading edge.") AnnotationAssertion(rdfs:label "protein localization to cell leading edge") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of protein localization to synapse) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:kmv") Annotation( "PMID:22588719") "Any process that modulates the frequency, rate or extent of protein localization to synapse.") AnnotationAssertion(rdfs:label "regulation of protein localization to synapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to synapse) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:kmv") Annotation( "PMID:22588719") "Any process that activates or increases the frequency, rate or extent of protein localization to synapse.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to synapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (cholangiocyte apoptotic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:22961800") "Any apoptotic process in a cholangiocyte.") +AnnotationAssertion(rdfs:label "cholangiocyte apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (hepatoblast apoptotic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:22412967") "Any apoptotic process in a hepatoblast.") +AnnotationAssertion(rdfs:label "hepatoblast apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (catalytic complex) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "PMID:8077207") "A protein complex which is capable of catalytic activity.") +AnnotationAssertion(rdfs:label "catalytic complex") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (transmembrane transporter complex) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "PMID:18024586") "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other.") +AnnotationAssertion(rdfs:label "transmembrane transporter complex") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (regulation of apoptotic DNA fragmentation) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:hjd") Annotation( "PMID:15572351") Annotation( "PMID:15723341") "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation.") +AnnotationAssertion(rdfs:comment "DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).") +AnnotationAssertion(rdfs:label "regulation of apoptotic DNA fragmentation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of apoptotic DNA fragmentation) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:hjd") Annotation( "PMID:15572351") "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation.") +AnnotationAssertion(rdfs:label "negative regulation of apoptotic DNA fragmentation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of apoptotic DNA fragmentation) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:hjd") Annotation( "PMID:15572351") "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation.") +AnnotationAssertion(rdfs:label "positive regulation of apoptotic DNA fragmentation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of organelle transport along microtubule) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "PMID:21147087") "Any process that modulates the frequency, rate or extent of organelle transport along microtubule.") AnnotationAssertion(rdfs:label "regulation of organelle transport along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of intracellular signal transduction) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:signaling") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of intracellular signal transduction.") AnnotationAssertion(rdfs:label "regulation of intracellular signal transduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of intracellular signal transduction) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:signaling") Annotation( "GOC:tb") "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.") AnnotationAssertion(rdfs:label "negative regulation of intracellular signal transduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of intracellular signal transduction) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:signaling") Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.") AnnotationAssertion(rdfs:label "positive regulation of intracellular signal transduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to nucleolus) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:22809626") "A process in which a protein is transported to, or maintained in, a location within a nucleolus.") AnnotationAssertion(rdfs:label "protein localization to nucleolus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of RNA biosynthetic process) +AnnotationAssertion(Annotation( "GO:jl") Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.") AnnotationAssertion(rdfs:label "negative regulation of RNA biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of RNA biosynthetic process) +AnnotationAssertion(Annotation( "GO:jl") Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process.") AnnotationAssertion(rdfs:label "positive regulation of RNA biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of neuroblast proliferation) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:21168496") "Any process that modulates the frequency, rate or extent of neuroblast proliferation.") AnnotationAssertion(rdfs:label "regulation of neuroblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of chondrocyte differentiation involved in endochondral bone morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:8662546") "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.") AnnotationAssertion(rdfs:label "regulation of chondrocyte differentiation involved in endochondral bone morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26177,11 +34620,13 @@ SubClassOf( (apoptotic process involved in development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:pg") Annotation( "GO_REF:0000060") "Any apoptotic process that is involved in anatomical structure development.") AnnotationAssertion(rdfs:label "apoptotic process involved in development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of chondrocyte development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:16575901") "Any process that activates or increases the frequency, rate or extent of chondrocyte development.") AnnotationAssertion(rdfs:label "positive regulation of chondrocyte development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26190,129 +34635,157 @@ SubClassOf( (regulation of skeletal muscle fiber differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:17879321") "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation.") AnnotationAssertion(rdfs:label "regulation of skeletal muscle fiber differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of skeletal muscle fiber differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:17879321") "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation.") AnnotationAssertion(rdfs:label "negative regulation of skeletal muscle fiber differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of skeletal muscle fiber differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:17879321") "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation.") AnnotationAssertion(rdfs:label "positive regulation of skeletal muscle fiber differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of protein localization to microtubule) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:vw") Annotation( "GO_REF:0000058") Annotation( "PMID:23087209") "Any process that modulates the frequency, rate or extent of protein localization to microtubule.") AnnotationAssertion(rdfs:label "regulation of protein localization to microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to microtubule) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:vw") Annotation( "GO_REF:0000058") Annotation( "PMID:23087209") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of nuclear migration along microtubule) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23087209") "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule.") AnnotationAssertion(rdfs:label "regulation of nuclear migration along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of nuclear migration along microtubule) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23087209") "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule.") AnnotationAssertion(rdfs:label "negative regulation of nuclear migration along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of nuclear migration along microtubule) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23087209") "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule.") AnnotationAssertion(rdfs:label "positive regulation of nuclear migration along microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (microtubule cytoskeleton organization involved in mitosis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000060") Annotation( "PMID:18799626") "Any microtubule cytoskeleton organization that is involved in mitosis.") AnnotationAssertion(rdfs:label "microtubule cytoskeleton organization involved in mitosis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of embryonic camera-type eye development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:16872597") "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development.") AnnotationAssertion(rdfs:label "regulation of embryonic camera-type eye development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of embryonic camera-type eye development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:16872597") "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development.") AnnotationAssertion(rdfs:label "negative regulation of embryonic camera-type eye development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of embryonic camera-type eye development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:16872597") "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development.") AnnotationAssertion(rdfs:label "positive regulation of embryonic camera-type eye development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of retina development in camera-type eye) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:16872597") "Any process that modulates the frequency, rate or extent of retina development in camera-type eye.") AnnotationAssertion(rdfs:label "regulation of retina development in camera-type eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of retina development in camera-type eye) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:16872597") "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye.") AnnotationAssertion(rdfs:label "negative regulation of retina development in camera-type eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of retina development in camera-type eye) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:16872597") "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye.") AnnotationAssertion(rdfs:label "positive regulation of retina development in camera-type eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of embryonic pattern specification) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:16872597") "Any process that modulates the frequency, rate or extent of embryonic pattern specification.") AnnotationAssertion(rdfs:label "regulation of embryonic pattern specification") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of embryonic pattern specification) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:16872597") "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification.") AnnotationAssertion(rdfs:label "negative regulation of embryonic pattern specification") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of embryonic pattern specification) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:16872597") "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification.") AnnotationAssertion(rdfs:label "positive regulation of embryonic pattern specification") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of supramolecular fiber organization) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:23921388") "Any process that modulates the frequency, rate or extent of supramolecular fiber organization.") +AnnotationAssertion(rdfs:comment "HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro") AnnotationAssertion(rdfs:label "regulation of supramolecular fiber organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of supramolecular fiber organization) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:23921388") "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization.") +AnnotationAssertion(rdfs:comment "HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro") AnnotationAssertion(rdfs:label "negative regulation of supramolecular fiber organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of supramolecular fiber organization) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:23921388") "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization.") +AnnotationAssertion(rdfs:comment "HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro") AnnotationAssertion(rdfs:label "positive regulation of supramolecular fiber organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of neuroepithelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:16916506") "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of neuroepithelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (organelle disassembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000079") "The disaggregation of an organelle into its constituent components.") AnnotationAssertion(rdfs:label "organelle disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of bone development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:22510437") "Any process that modulates the frequency, rate or extent of bone development.") AnnotationAssertion(rdfs:label "regulation of bone development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of bone development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:22510437") "Any process that stops, prevents or reduces the frequency, rate or extent of bone development.") AnnotationAssertion(rdfs:label "negative regulation of bone development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26321,6 +34794,7 @@ SubClassOf( (positive regulation of bone development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:22510437") "Any process that activates or increases the frequency, rate or extent of bone development.") AnnotationAssertion(rdfs:label "positive regulation of bone development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26329,27 +34803,37 @@ SubClassOf( (regulation of glycoprotein metabolic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:23544079") "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process.") +AnnotationAssertion(rdfs:comment "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein") AnnotationAssertion(rdfs:label "regulation of glycoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of glycoprotein metabolic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:23544079") "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process.") +AnnotationAssertion(rdfs:comment "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein") AnnotationAssertion(rdfs:label "negative regulation of glycoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of glycoprotein metabolic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:23544079") "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process.") +AnnotationAssertion(rdfs:comment "human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein") AnnotationAssertion(rdfs:label "positive regulation of glycoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of leukocyte cell-cell adhesion) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:21106532") "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion.") +AnnotationAssertion(rdfs:comment "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion") AnnotationAssertion(rdfs:label "regulation of leukocyte cell-cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of leukocyte cell-cell adhesion) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:21106532") "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion.") +AnnotationAssertion(rdfs:comment "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion") AnnotationAssertion(rdfs:label "negative regulation of leukocyte cell-cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26357,6 +34841,8 @@ SubClassOf( (positive regulation of leukocyte cell-cell adhesion) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:21106532") "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion.") +AnnotationAssertion(rdfs:comment "Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion") AnnotationAssertion(rdfs:label "positive regulation of leukocyte cell-cell adhesion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26364,11 +34850,14 @@ SubClassOf( (neural crest cell migration involved in sympathetic nervous system development) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000060") Annotation( "PMID:19325129") "Any neural crest cell migration that is involved in sympathetic nervous system development.") +AnnotationAssertion(rdfs:comment "Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development") AnnotationAssertion(rdfs:label "neural crest cell migration involved in sympathetic nervous system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (meiotic cell cycle process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_cell_cycle") Annotation( "GO_REF:0000060") "A process that is part of the meiotic cell cycle.") AnnotationAssertion(rdfs:label "meiotic cell cycle process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26378,17 +34867,20 @@ DisjointClasses( (mitotic cell cycle process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_cell_cycle") Annotation( "GO_REF:0000060") "A process that is part of the mitotic cell cycle.") AnnotationAssertion(rdfs:label "mitotic cell cycle process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of extracellular matrix organization) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:22357537") "Any process that modulates the frequency, rate or extent of extracellular matrix organization.") AnnotationAssertion(rdfs:label "regulation of extracellular matrix organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of extracellular matrix organization) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:22357537") "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization.") AnnotationAssertion(rdfs:label "negative regulation of extracellular matrix organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26396,6 +34888,7 @@ SubClassOf( (positive regulation of extracellular matrix organization) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:22357537") "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization.") AnnotationAssertion(rdfs:label "positive regulation of extracellular matrix organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26403,112 +34896,146 @@ SubClassOf( (regulation of protein localization to plasma membrane) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:11602640") "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.") AnnotationAssertion(rdfs:label "regulation of protein localization to plasma membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to plasma membrane) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:11602640") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to plasma membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to plasma membrane) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:11602640") "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to plasma membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of actin filament-based movement) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24798735") "Any process that modulates the frequency, rate or extent of actin filament-based movement.") AnnotationAssertion(rdfs:label "regulation of actin filament-based movement") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of actin filament-based movement) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24798735") "Any process that activates or increases the frequency, rate or extent of actin filament-based movement.") AnnotationAssertion(rdfs:label "positive regulation of actin filament-based movement") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to actin cytoskeleton) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000087") Annotation( "PMID:24798735") "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton.") AnnotationAssertion(rdfs:label "protein localization to actin cytoskeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to actin filament bundle) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000087") Annotation( "PMID:24798735") "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle.") AnnotationAssertion(rdfs:label "protein localization to actin filament bundle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mononuclear cell differentiation) +AnnotationAssertion(Annotation( "CL:0000842") Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000086") Annotation( "PMID:24759906") "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell.") AnnotationAssertion(rdfs:label "mononuclear cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of endodermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:23154389") "Any process that modulates the frequency, rate or extent of endodermal cell differentiation.") AnnotationAssertion(rdfs:label "regulation of endodermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of endodermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:23154389") "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of endodermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of endodermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:23154389") "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of endodermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (multi-ciliated epithelial cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:sp") Annotation( "GO_REF:0000086") Annotation( "PMID:22231168") Annotation( "PMID:24934224") "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.") AnnotationAssertion(rdfs:label "multi-ciliated epithelial cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to Golgi membrane) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000087") Annotation( "PMID:11378902") "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.") AnnotationAssertion(rdfs:label "protein localization to Golgi membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of vacuolar transport) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:vw") Annotation( "GO_REF:0000058") "Any process that modulates the frequency, rate or extent of vacuolar transport.") AnnotationAssertion(rdfs:label "regulation of vacuolar transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of vacuolar transport) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:vw") Annotation( "GO_REF:0000058") "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport.") AnnotationAssertion(rdfs:label "negative regulation of vacuolar transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of vacuolar transport) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:vw") Annotation( "GO_REF:0000058") "Any process that activates or increases the frequency, rate or extent of vacuolar transport.") AnnotationAssertion(rdfs:label "positive regulation of vacuolar transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of nucleus organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:16943282") "Any process that modulates the frequency, rate or extent of nucleus organization.") AnnotationAssertion(rdfs:label "regulation of nucleus organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of Golgi organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:17562788") "Any process that modulates the frequency, rate or extent of Golgi organization.") AnnotationAssertion(rdfs:label "regulation of Golgi organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of mitotic chromosome condensation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:9490640") "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation.") AnnotationAssertion(rdfs:label "regulation of mitotic chromosome condensation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of mitotic chromosome condensation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:9490640") "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation.") AnnotationAssertion(rdfs:label "positive regulation of mitotic chromosome condensation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (response to bile acid) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000071") Annotation( "PMID:21757002") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.") +AnnotationAssertion(rdfs:label "response to bile acid") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (cellular response to bile acid) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000071") Annotation( "PMID:21757002") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus.") +AnnotationAssertion(rdfs:label "cellular response to bile acid") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of cell maturation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17459944") "Any process that modulates the frequency, rate or extent of cell maturation.") AnnotationAssertion(rdfs:label "regulation of cell maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of cell maturation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17459944") "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation.") AnnotationAssertion(rdfs:label "negative regulation of cell maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26516,6 +35043,7 @@ SubClassOf( (positive regulation of cell maturation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17459944") "Any process that activates or increases the frequency, rate or extent of cell maturation.") AnnotationAssertion(rdfs:label "positive regulation of cell maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26523,17 +35051,26 @@ SubClassOf( (protein localization to ciliary membrane) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000087") Annotation( "PMID:22139371") "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane.") AnnotationAssertion(rdfs:label "protein localization to ciliary membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (mucopolysaccharide metabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GO_REF:0000068") Annotation( "PMID:4236091") "The chemical reactions and pathways involving mucopolysaccharide.") +AnnotationAssertion(rdfs:label "mucopolysaccharide metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of blood circulation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:10659969") "Any process that modulates the frequency, rate or extent of blood circulation.") AnnotationAssertion(rdfs:label "regulation of blood circulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of blood circulation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:10659969") "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation.") AnnotationAssertion(rdfs:label "negative regulation of blood circulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26541,6 +35078,7 @@ SubClassOf( (positive regulation of blood circulation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000058") Annotation( "PMID:10659969") "Any process that activates or increases the frequency, rate or extent of blood circulation.") AnnotationAssertion(rdfs:label "positive regulation of blood circulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26548,6 +35086,7 @@ SubClassOf( (regulation of secretion by cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pm") Annotation( "GO_REF:0000058") Annotation( "PMID:12130530") "Any process that modulates the frequency, rate or extent of secretion by cell.") AnnotationAssertion(rdfs:label "regulation of secretion by cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26555,6 +35094,7 @@ SubClassOf( (negative regulation of secretion by cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pm") Annotation( "GO_REF:0000058") Annotation( "PMID:12130530") "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell.") AnnotationAssertion(rdfs:label "negative regulation of secretion by cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26563,6 +35103,7 @@ SubClassOf( (positive regulation of secretion by cell) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pm") Annotation( "GO_REF:0000058") Annotation( "PMID:12130530") "Any process that activates or increases the frequency, rate or extent of secretion by cell.") AnnotationAssertion(rdfs:label "positive regulation of secretion by cell") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26571,103 +35112,142 @@ SubClassOf( (meiotic cell cycle process involved in oocyte maturation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:jz") Annotation( "GO_REF:0000060") Annotation( "PMID:25212395") "Any meiotic cell cycle process that is involved in oocyte maturation.") AnnotationAssertion(rdfs:label "meiotic cell cycle process involved in oocyte maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of meiotic cell cycle process involved in oocyte maturation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:jz") Annotation( "GO_REF:0000058") Annotation( "PMID:25212395") "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.") AnnotationAssertion(rdfs:label "regulation of meiotic cell cycle process involved in oocyte maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of exosomal secretion) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24105262") "Any process that modulates the frequency, rate or extent of exosomal secretion.") AnnotationAssertion(rdfs:label "regulation of exosomal secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of exosomal secretion) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24105262") "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion.") AnnotationAssertion(rdfs:label "negative regulation of exosomal secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of exosomal secretion) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24105262") "Any process that activates or increases the frequency, rate or extent of exosomal secretion.") AnnotationAssertion(rdfs:label "positive regulation of exosomal secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of extracellular exosome assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24105262") "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly.") AnnotationAssertion(rdfs:label "regulation of extracellular exosome assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of extracellular exosome assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24105262") "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly.") AnnotationAssertion(rdfs:label "negative regulation of extracellular exosome assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of extracellular exosome assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24105262") "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly.") AnnotationAssertion(rdfs:label "positive regulation of extracellular exosome assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (extracellular vesicle) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pm") Annotation( "GO_REF:0000064") Annotation( "PMID:24769233") "Any vesicle that is part of the extracellular region.") AnnotationAssertion(rdfs:label "extracellular vesicle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of protein localization to cilium) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000058") Annotation( "PMID:22072986") "Any process that modulates the frequency, rate or extent of protein localization to cilium.") AnnotationAssertion(rdfs:label "regulation of protein localization to cilium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to cilium) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000058") Annotation( "PMID:22072986") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to cilium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to cilium) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000058") Annotation( "PMID:22072986") "Any process that activates or increases the frequency, rate or extent of protein localization to cilium.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to cilium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of protein localization to ciliary membrane) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000058") Annotation( "PMID:22072986") "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane.") AnnotationAssertion(rdfs:label "regulation of protein localization to ciliary membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to ciliary membrane) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000058") Annotation( "PMID:22072986") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to ciliary membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to ciliary membrane) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000058") Annotation( "PMID:22072986") "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to ciliary membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of DNA catabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:2001740") "Any process that modulates the frequency, rate or extent of DNA catabolic process.") +AnnotationAssertion(rdfs:label "regulation of DNA catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of DNA catabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:2001740") "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process.") +AnnotationAssertion(rdfs:label "negative regulation of DNA catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of DNA catabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:2001740") "Any process that activates or increases the frequency, rate or extent of DNA catabolic process.") +AnnotationAssertion(rdfs:label "positive regulation of DNA catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (negative regulation of microvillus assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:22797597") "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly.") AnnotationAssertion(rdfs:label "negative regulation of microvillus assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of microvillus assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:22797597") "Any process that activates or increases the frequency, rate or extent of microvillus assembly.") AnnotationAssertion(rdfs:label "positive regulation of microvillus assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (substantia propria of cornea development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000094") Annotation( "PMID:12556382") "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "substantia propria of cornea development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (esophagus development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000094") Annotation( "ISBN:0-683-40008-8") "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "esophagus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of hemopoiesis) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:pad") Annotation( "GO_REF:0000058") Annotation( "PMID:20080761") "Any process that modulates the frequency, rate or extent of hemopoiesis.") +AnnotationAssertion(rdfs:comment "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.") AnnotationAssertion(rdfs:label "regulation of hemopoiesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26675,6 +35255,8 @@ SubClassOf( (negative regulation of hemopoiesis) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:pad") Annotation( "GO_REF:0000058") Annotation( "PMID:20080761") "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.") +AnnotationAssertion(rdfs:comment "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.") AnnotationAssertion(rdfs:label "negative regulation of hemopoiesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26684,6 +35266,8 @@ SubClassOf( (positive regulation of hemopoiesis) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:pad") Annotation( "GO_REF:0000058") Annotation( "PMID:20080761") "Any process that activates or increases the frequency, rate or extent of hemopoiesis.") +AnnotationAssertion(rdfs:comment "An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.") AnnotationAssertion(rdfs:label "positive regulation of hemopoiesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26693,83 +35277,105 @@ SubClassOf( (regulation of plasma membrane organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24514900") "Any process that modulates the frequency, rate or extent of plasma membrane organization.") AnnotationAssertion(rdfs:label "regulation of plasma membrane organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to vacuolar membrane) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000087") Annotation( "PMID:25378562") "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane.") AnnotationAssertion(rdfs:label "protein localization to vacuolar membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cardiac conduction) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:12967627") "Any process that modulates the frequency, rate or extent of cardiac conduction.") AnnotationAssertion(rdfs:label "regulation of cardiac conduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac conduction) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:12967627") "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction.") AnnotationAssertion(rdfs:label "negative regulation of cardiac conduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardiac conduction) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:12967627") "Any process that activates or increases the frequency, rate or extent of cardiac conduction.") AnnotationAssertion(rdfs:label "positive regulation of cardiac conduction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (organic acid transmembrane transport) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000069") "The process in which an organic acid is transported across a membrane.") +AnnotationAssertion(rdfs:label "organic acid transmembrane transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) + # Class: (negative regulation of protein localization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:vw") Annotation( "GO_REF:0000058") "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization.") AnnotationAssertion(rdfs:label "negative regulation of protein localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:vw") Annotation( "GO_REF:0000058") "Any process that activates or increases the frequency, rate or extent of a protein localization.") AnnotationAssertion(rdfs:label "positive regulation of protein localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (signal transduction involved in cellular response to ammonium ion) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000060") Annotation( "PMID:16297994") "Any signal transduction that is involved in cellular response to ammonium ion.") AnnotationAssertion(rdfs:label "signal transduction involved in cellular response to ammonium ion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of aorta morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:22269326") "Any process that modulates the frequency, rate or extent of aorta morphogenesis.") AnnotationAssertion(rdfs:label "regulation of aorta morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of aorta morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:22269326") "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of aorta morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of aorta morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:22269326") "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis.") AnnotationAssertion(rdfs:label "positive regulation of aorta morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (extraembryonic membrane development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000094") Annotation( "ISBN:0073040584") "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "extraembryonic membrane development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of establishment of T cell polarity) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:23575248") "Any process that modulates the frequency, rate or extent of establishment of T cell polarity.") AnnotationAssertion(rdfs:label "regulation of establishment of T cell polarity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of establishment of T cell polarity) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:23575248") "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity.") AnnotationAssertion(rdfs:label "negative regulation of establishment of T cell polarity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of establishment of T cell polarity) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:23575248") "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity.") AnnotationAssertion(rdfs:label "positive regulation of establishment of T cell polarity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of respiratory gaseous exchange) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:22819705") "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange.") AnnotationAssertion(rdfs:label "negative regulation of respiratory gaseous exchange") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26777,48 +35383,75 @@ SubClassOf( (positive regulation of respiratory gaseous exchange) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:22819705") "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange.") AnnotationAssertion(rdfs:label "positive regulation of respiratory gaseous exchange") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (regulation of hepatocyte apoptotic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:8649852") "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process.") +AnnotationAssertion(rdfs:label "regulation of hepatocyte apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of hepatocyte apoptotic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:8649852") "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process.") +AnnotationAssertion(rdfs:label "negative regulation of hepatocyte apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of hepatocyte apoptotic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:8649852") "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process.") +AnnotationAssertion(rdfs:label "positive regulation of hepatocyte apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (negative regulation of AV node cell action potential) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:25281747") "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential.") AnnotationAssertion(rdfs:label "negative regulation of AV node cell action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of AV node cell action potential) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:25281747") "Any process that activates or increases the frequency, rate or extent of AV node cell action potential.") AnnotationAssertion(rdfs:label "positive regulation of AV node cell action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of glial cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:19100238") "Any process that modulates the frequency, rate or extent of glial cell migration.") AnnotationAssertion(rdfs:label "regulation of glial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of glial cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:19100238") "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration.") AnnotationAssertion(rdfs:label "negative regulation of glial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of glial cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:19100238") "Any process that activates or increases the frequency, rate or extent of glial cell migration.") AnnotationAssertion(rdfs:label "positive regulation of glial cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (response to serotonin) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000071") Annotation( "PMID:1505525") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.") AnnotationAssertion(rdfs:label "response to serotonin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular response to serotonin) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000071") Annotation( "PMID:1505525") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.") AnnotationAssertion(rdfs:label "cellular response to serotonin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of vasculature development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:21472453") "Any process that activates or increases the frequency, rate or extent of vasculature development.") AnnotationAssertion(rdfs:label "positive regulation of vasculature development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26827,6 +35460,7 @@ SubClassOf( (epithelial cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000085") Annotation( "PMID:19137015") "Any apoptotic process in an epithelial cell.") AnnotationAssertion(rdfs:label "epithelial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26836,36 +35470,61 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (regulation of collagen fibril organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25451920") "Any process that modulates the frequency, rate or extent of collagen fibril organization.") AnnotationAssertion(rdfs:label "regulation of collagen fibril organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of collagen fibril organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25451920") "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization.") AnnotationAssertion(rdfs:label "negative regulation of collagen fibril organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of collagen fibril organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25451920") "Any process that activates or increases the frequency, rate or extent of collagen fibril organization.") AnnotationAssertion(rdfs:label "positive regulation of collagen fibril organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of epithelial cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:19137015") "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process.") AnnotationAssertion(rdfs:label "regulation of epithelial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of epithelial cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:19137015") "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of epithelial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of epithelial cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:19137015") "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of epithelial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of cholangiocyte proliferation) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24434010") "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation.") +AnnotationAssertion(rdfs:label "regulation of cholangiocyte proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of cholangiocyte proliferation) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24434010") "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation.") +AnnotationAssertion(rdfs:label "negative regulation of cholangiocyte proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of cholangiocyte proliferation) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24434010") "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation.") +AnnotationAssertion(rdfs:label "positive regulation of cholangiocyte proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (negative regulation of sensory perception of pain) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17167094") "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain.") AnnotationAssertion(rdfs:label "negative regulation of sensory perception of pain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26873,6 +35532,7 @@ SubClassOf( (positive regulation of sensory perception of pain) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17167094") "Any process that activates or increases the frequency, rate or extent of sensory perception of pain.") AnnotationAssertion(rdfs:label "positive regulation of sensory perception of pain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -26880,27 +35540,32 @@ SubClassOf( (regulation of trophectodermal cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24508636") "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation.") AnnotationAssertion(rdfs:label "regulation of trophectodermal cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of trophectodermal cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24508636") "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of trophectodermal cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of trophectodermal cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24508636") "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of trophectodermal cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to microvillus) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:kmv") Annotation( "GO_REF:0000087") Annotation( "PMID:25335890") "A process in which a protein is transported to, or maintained in, a location within a microvillus.") AnnotationAssertion(rdfs:label "protein localization to microvillus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of meiotic cell cycle process involved in oocyte maturation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:22674394") "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.") AnnotationAssertion(rdfs:label "negative regulation of meiotic cell cycle process involved in oocyte maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -26908,405 +35573,659 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of meiotic cell cycle process involved in oocyte maturation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:22674394") "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.") AnnotationAssertion(rdfs:label "positive regulation of meiotic cell cycle process involved in oocyte maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of bleb assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:25651887") "Any process that modulates the frequency, rate or extent of bleb assembly.") AnnotationAssertion(rdfs:label "regulation of bleb assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of bleb assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:25651887") "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly.") AnnotationAssertion(rdfs:label "negative regulation of bleb assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of bleb assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:als") Annotation( "GO_REF:0000058") Annotation( "PMID:25651887") "Any process that activates or increases the frequency, rate or extent of bleb assembly.") AnnotationAssertion(rdfs:label "positive regulation of bleb assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of adipose tissue development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23081848") "Any process that modulates the frequency, rate or extent of adipose tissue development.") AnnotationAssertion(rdfs:label "regulation of adipose tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of adipose tissue development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23081848") "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development.") AnnotationAssertion(rdfs:label "negative regulation of adipose tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of adipose tissue development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23081848") "Any process that activates or increases the frequency, rate or extent of adipose tissue development.") AnnotationAssertion(rdfs:label "positive regulation of adipose tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (regulation of cholangiocyte apoptotic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24498161") "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process.") +AnnotationAssertion(rdfs:label "regulation of cholangiocyte apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of cholangiocyte apoptotic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24498161") "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process.") +AnnotationAssertion(rdfs:label "negative regulation of cholangiocyte apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of cholangiocyte apoptotic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24498161") "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process.") +AnnotationAssertion(rdfs:label "positive regulation of cholangiocyte apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of skeletal muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23470307") "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy.") AnnotationAssertion(rdfs:label "regulation of skeletal muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of skeletal muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23470307") "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy.") AnnotationAssertion(rdfs:label "negative regulation of skeletal muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of skeletal muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23470307") "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy.") AnnotationAssertion(rdfs:label "positive regulation of skeletal muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (pericyte cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GO_REF:0000086") Annotation( "PMID:23868830") "The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell.") AnnotationAssertion(rdfs:label "pericyte cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of bile acid metabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") "Any process that modulates the frequency, rate or extent of bile acid metabolic process.") +AnnotationAssertion(rdfs:label "regulation of bile acid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (negative regulation of bile acid metabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process.") +AnnotationAssertion(rdfs:label "negative regulation of bile acid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of bile acid metabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process.") +AnnotationAssertion(rdfs:label "positive regulation of bile acid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (cell leading edge cell cortex) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:kmv") Annotation( "GO_REF:0000064") Annotation( "PMID:25843030") "The cell cortex of the leading edge of a cell.") AnnotationAssertion(rdfs:label "cell leading edge cell cortex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (regulation of gastro-intestinal system smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:10821044") "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.") +AnnotationAssertion(rdfs:label "regulation of gastro-intestinal system smooth muscle contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of gastro-intestinal system smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:10821044") "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.") +AnnotationAssertion(rdfs:label "negative regulation of gastro-intestinal system smooth muscle contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of gastro-intestinal system smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:10821044") "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.") +AnnotationAssertion(rdfs:label "positive regulation of gastro-intestinal system smooth muscle contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (regulation of colon smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24170253") "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction.") +AnnotationAssertion(rdfs:label "regulation of colon smooth muscle contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (negative regulation of colon smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24170253") "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction.") +AnnotationAssertion(rdfs:label "negative regulation of colon smooth muscle contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (positive regulation of colon smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24170253") "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction.") +AnnotationAssertion(rdfs:label "positive regulation of colon smooth muscle contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (regulation of gastric mucosal blood circulation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:10807413") "Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation.") AnnotationAssertion(rdfs:label "regulation of gastric mucosal blood circulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of gastric mucosal blood circulation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:10807413") "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation.") AnnotationAssertion(rdfs:label "negative regulation of gastric mucosal blood circulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of gastric mucosal blood circulation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:10807413") "Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation.") AnnotationAssertion(rdfs:label "positive regulation of gastric mucosal blood circulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of small intestine smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:11991626") "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction.") +AnnotationAssertion(rdfs:label "regulation of small intestine smooth muscle contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (negative regulation of small intestine smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:11991626") "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction.") +AnnotationAssertion(rdfs:label "negative regulation of small intestine smooth muscle contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (positive regulation of small intestine smooth muscle contraction) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:11991626") "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction.") +AnnotationAssertion(rdfs:label "positive regulation of small intestine smooth muscle contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (regulation of protein catabolic process in the vacuole) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:25635054") "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole.") +AnnotationAssertion(rdfs:label "regulation of protein catabolic process in the vacuole") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of protein catabolic process in the vacuole) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:25635054") "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole.") +AnnotationAssertion(rdfs:label "negative regulation of protein catabolic process in the vacuole") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of protein catabolic process in the vacuole) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:25635054") "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole.") +AnnotationAssertion(rdfs:label "positive regulation of protein catabolic process in the vacuole") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of protein localization to cell periphery) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:18216290") "Any process that modulates the frequency, rate or extent of protein localization to cell periphery.") AnnotationAssertion(rdfs:label "regulation of protein localization to cell periphery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to cell periphery) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:18216290") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to cell periphery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to cell periphery) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:18216290") "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to cell periphery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of neuromuscular junction development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:7722643") "Any process that modulates the frequency, rate or extent of neuromuscular junction development.") AnnotationAssertion(rdfs:label "regulation of neuromuscular junction development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of neuromuscular junction development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:7722643") "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development.") AnnotationAssertion(rdfs:label "negative regulation of neuromuscular junction development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of neuromuscular junction development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:7722643") "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development.") AnnotationAssertion(rdfs:label "positive regulation of neuromuscular junction development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of secretory granule organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:15039777") "Any process that modulates the frequency, rate or extent of secretory granule organization.") AnnotationAssertion(rdfs:label "regulation of secretory granule organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of secretory granule organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:15039777") "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization.") AnnotationAssertion(rdfs:label "negative regulation of secretory granule organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of secretory granule organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:15039777") "Any process that activates or increases the frequency, rate or extent of secretory granule organization.") AnnotationAssertion(rdfs:label "positive regulation of secretory granule organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cardiac ventricle development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:19590510") "Any process that modulates the frequency, rate or extent of cardiac ventricle development.") AnnotationAssertion(rdfs:label "regulation of cardiac ventricle development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac ventricle development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:19590510") "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development.") AnnotationAssertion(rdfs:label "negative regulation of cardiac ventricle development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of cardiac ventricle development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:19590510") "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development.") AnnotationAssertion(rdfs:label "positive regulation of cardiac ventricle development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of neuronal action potential) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25126967") "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential.") AnnotationAssertion(rdfs:label "negative regulation of neuronal action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of neuronal action potential) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25126967") "Any process that activates or increases the frequency, rate or extent of neuronal action potential.") AnnotationAssertion(rdfs:label "positive regulation of neuronal action potential") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (cloacal gland development) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mr") Annotation( "GO_REF:0000094") Annotation( "PMID:18805421") "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure.") +AnnotationAssertion(rdfs:label "cloacal gland development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (protein localization to ciliary transition zone) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:kmv") Annotation( "GO_REF:0000087") Annotation( "PMID:21422230") "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone.") AnnotationAssertion(rdfs:label "protein localization to ciliary transition zone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (response to glycoprotein) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000071") Annotation( "PMID:14597422") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.") AnnotationAssertion(rdfs:label "response to glycoprotein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cellular response to glycoprotein) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000071") Annotation( "PMID:14597422") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.") AnnotationAssertion(rdfs:label "cellular response to glycoprotein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (fat cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000085") Annotation( "PMID:17024416") "Any apoptotic process in a fat cell.") AnnotationAssertion(rdfs:label "fat cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of fat cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17024416") "Any process that modulates the frequency, rate or extent of fat cell apoptotic process.") AnnotationAssertion(rdfs:label "regulation of fat cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of fat cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17024416") "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of fat cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of fat cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17024416") "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of fat cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of lung alveolus development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23962064") "Any process that modulates the frequency, rate or extent of lung alveolus development.") AnnotationAssertion(rdfs:label "regulation of lung alveolus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of lung alveolus development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23962064") "Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development.") AnnotationAssertion(rdfs:label "negative regulation of lung alveolus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of lung alveolus development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23962064") "Any process that activates or increases the frequency, rate or extent of lung alveolus development.") AnnotationAssertion(rdfs:label "positive regulation of lung alveolus development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (glucose transmembrane transport) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000069") Annotation( "PMID:9090050") "The process in which glucose is transported across a membrane.") +AnnotationAssertion(rdfs:label "glucose transmembrane transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) + # Class: (regulation of somatic stem cell division) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:19409607") "Any process that modulates the frequency, rate or extent of somatic stem cell division.") AnnotationAssertion(rdfs:label "regulation of somatic stem cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of somatic stem cell division) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:19409607") "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division.") AnnotationAssertion(rdfs:label "negative regulation of somatic stem cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of somatic stem cell division) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:19409607") "Any process that activates or increases the frequency, rate or extent of somatic stem cell division.") AnnotationAssertion(rdfs:label "positive regulation of somatic stem cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (peptide transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:vw") Annotation( "GO_REF:0000070") "Enables the transfer of a peptide from one side of a membrane to the other.") +AnnotationAssertion(Annotation(rdfs:label "Glutathione is taken up by the bacterium") "Reactome:R-HSA-1500817") +AnnotationAssertion(rdfs:label "peptide transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of type B pancreatic cell proliferation) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24055447") "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation.") +AnnotationAssertion(rdfs:label "negative regulation of type B pancreatic cell proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of type B pancreatic cell proliferation) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:24055447") "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation.") +AnnotationAssertion(rdfs:label "positive regulation of type B pancreatic cell proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (midbrain morphogenesis) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000083") Annotation( "PMID:21347250") "The developmental process by which a midbrain is generated and organized.") AnnotationAssertion(rdfs:label "midbrain morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (regulation of acinar cell proliferation) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:9788538") "Any process that modulates the frequency, rate or extent of acinar cell proliferation.") +AnnotationAssertion(rdfs:label "regulation of acinar cell proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of acinar cell proliferation) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:9788538") "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation.") +AnnotationAssertion(rdfs:label "negative regulation of acinar cell proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of acinar cell proliferation) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:9788538") "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation.") +AnnotationAssertion(rdfs:label "positive regulation of acinar cell proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of vascular associated smooth muscle cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23246467") "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation.") AnnotationAssertion(rdfs:label "regulation of vascular associated smooth muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of vascular associated smooth muscle cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23246467") "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of vascular associated smooth muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of vascular associated smooth muscle cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23246467") "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of vascular associated smooth muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (vascular associated smooth muscle cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000091") Annotation( "PMID:20693317") "The orderly movement of a vascular associated smooth muscle cell from one site to another.") AnnotationAssertion(rdfs:label "vascular associated smooth muscle cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of apoptotic process involved in development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:22801495") "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development.") +AnnotationAssertion(rdfs:comment "U4PR86 in PMID:22801495 inferred from mutant phenotype") AnnotationAssertion(rdfs:label "negative regulation of apoptotic process involved in development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of apoptotic process involved in development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:22801495") "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development.") +AnnotationAssertion(rdfs:comment "U4PR86 in PMID:22801495 inferred from mutant phenotype") AnnotationAssertion(rdfs:label "positive regulation of apoptotic process involved in development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of apoptotic process involved in development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:22801495") "Any process that modulates the frequency, rate or extent of apoptotic process involved in development.") +AnnotationAssertion(rdfs:comment "Q10943 in PMID:22801495, inferred from mutant phenotype") AnnotationAssertion(rdfs:label "regulation of apoptotic process involved in development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of protein localization to nucleolus) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_telomere") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:24415760") "Any process that modulates the frequency, rate or extent of protein localization to nucleolus.") AnnotationAssertion(rdfs:label "regulation of protein localization to nucleolus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to nucleolus) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_telomere") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:24415760") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to nucleolus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to nucleolus) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_telomere") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:24415760") "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to nucleolus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of vascular associated smooth muscle cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:20693317") "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration.") AnnotationAssertion(rdfs:label "regulation of vascular associated smooth muscle cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of vascular associated smooth muscle cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:20693317") "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.") AnnotationAssertion(rdfs:label "negative regulation of vascular associated smooth muscle cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of vascular associated smooth muscle cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:20693317") "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration.") AnnotationAssertion(rdfs:label "positive regulation of vascular associated smooth muscle cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (intramembranous bone morphogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000083") Annotation( "PMID:26399686") "The developmental process by which an intramembranous bone is generated and organized.") AnnotationAssertion(rdfs:label "intramembranous bone morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of protein localization to cell cortex) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17115027") "Any process that modulates the frequency, rate or extent of protein localization to cell cortex.") +AnnotationAssertion(rdfs:comment "An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.") AnnotationAssertion(rdfs:label "regulation of protein localization to cell cortex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to cell cortex) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17115027") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex.") +AnnotationAssertion(rdfs:comment "An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to cell cortex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to cell cortex) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17115027") "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.") +AnnotationAssertion(rdfs:comment "An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to cell cortex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (serous membrane development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GO_REF:0000094") Annotation( "PMID:15840053") "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "serous membrane development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (visceral peritoneum development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GO_REF:0000094") Annotation( "PMID:15840053") "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "visceral peritoneum development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (parietal peritoneum development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GO_REF:0000094") Annotation( "PMID:15840053") "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "parietal peritoneum development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (peritoneum development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GO_REF:0000094") Annotation( "PMID:15840053") "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure.") AnnotationAssertion(rdfs:label "peritoneum development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of aortic smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:22034194") "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation.") AnnotationAssertion(rdfs:label "regulation of aortic smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of aortic smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:22034194") "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of aortic smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of aortic smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:22034194") "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of aortic smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cranial skeletal system development) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000094") Annotation( "PMID:11262227") "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.") AnnotationAssertion(rdfs:label "cranial skeletal system development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cell proliferation in midbrain) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:18953410") Annotation( "PMID:24431302") "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain.") AnnotationAssertion(rdfs:label "regulation of cell proliferation in midbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cell proliferation in midbrain) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:18953410") Annotation( "PMID:24431302") "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain.") AnnotationAssertion(rdfs:label "negative regulation of cell proliferation in midbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cell proliferation in midbrain) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:24431302") "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain.") AnnotationAssertion(rdfs:label "positive regulation of cell proliferation in midbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (interneuron migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:ah") Annotation( "GO_REF:0000091") Annotation( "PMID:18622031") "The orderly movement of an interneuron from one site to another.") AnnotationAssertion(rdfs:label "interneuron migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (sensory neuron migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:ah") Annotation( "GO_REF:0000091") Annotation( "PMID:18622031") "The orderly movement of a sensory neuron from one site to another.") AnnotationAssertion(rdfs:label "sensory neuron migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cardiac ventricle formation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:23575307") "Any process that modulates the frequency, rate or extent of cardiac ventricle formation.") AnnotationAssertion(rdfs:label "regulation of cardiac ventricle formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac ventricle formation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:23575307") "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation.") AnnotationAssertion(rdfs:label "negative regulation of cardiac ventricle formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of cardiac ventricle formation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:23575307") "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation.") AnnotationAssertion(rdfs:label "positive regulation of cardiac ventricle formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of establishment of protein localization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:22761445") "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization.") AnnotationAssertion(rdfs:label "negative regulation of establishment of protein localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -27314,6 +36233,7 @@ SubClassOf( (positive regulation of establishment of protein localization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:22761445") "Any process that activates or increases the frequency, rate or extent of establishment of protein localization.") AnnotationAssertion(rdfs:label "positive regulation of establishment of protein localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -27321,143 +36241,202 @@ SubClassOf( (regulation of endothelial cell activation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:24255059") "Any process that modulates the frequency, rate or extent of endothelial cell activation.") AnnotationAssertion(rdfs:label "regulation of endothelial cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of endothelial cell activation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:24255059") "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation.") AnnotationAssertion(rdfs:label "negative regulation of endothelial cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of endothelial cell activation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:24255059") "Any process that activates or increases the frequency, rate or extent of endothelial cell activation.") AnnotationAssertion(rdfs:label "positive regulation of endothelial cell activation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (carboxylic acid transmembrane transport) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000069") Annotation( "PMID:10869563") "The process in which carboxylic acid is transported across a membrane.") +AnnotationAssertion(rdfs:label "carboxylic acid transmembrane transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) + # Class: (regulation of vascular associated smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:19088079") "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation.") AnnotationAssertion(rdfs:label "regulation of vascular associated smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of vascular associated smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:19088079") "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of vascular associated smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of vascular associated smooth muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:19088079") "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of vascular associated smooth muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of axo-dendritic protein transport) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:20694152") "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport.") AnnotationAssertion(rdfs:label "regulation of axo-dendritic protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of axo-dendritic protein transport) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:20694152") "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport.") AnnotationAssertion(rdfs:label "negative regulation of axo-dendritic protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of axo-dendritic protein transport) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:20694152") "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport.") AnnotationAssertion(rdfs:label "positive regulation of axo-dendritic protein transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (apical ectodermal ridge formation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000081") Annotation( "PMID:18359901") Annotation( "PMID:9323126") Annotation( "PMID:9596583") "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts.") AnnotationAssertion(rdfs:label "apical ectodermal ridge formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of apical ectodermal ridge formation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:18359901") "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation.") AnnotationAssertion(rdfs:label "regulation of apical ectodermal ridge formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of apical ectodermal ridge formation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:18359901") "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation.") AnnotationAssertion(rdfs:label "negative regulation of apical ectodermal ridge formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of apical ectodermal ridge formation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:18359901") "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation.") AnnotationAssertion(rdfs:label "positive regulation of apical ectodermal ridge formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (lysosomal protein catabolic process) + +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000062") Annotation( "PMID:24334770") "Any cellular protein catabolic process that takes place in a lysosome.") +AnnotationAssertion(rdfs:comment "Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants.") +AnnotationAssertion(rdfs:label "lysosomal protein catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of smooth muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:22161164") "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy.") AnnotationAssertion(rdfs:label "regulation of smooth muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of smooth muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:22161164") "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy.") AnnotationAssertion(rdfs:label "negative regulation of smooth muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of smooth muscle hypertrophy) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:22161164") "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy.") AnnotationAssertion(rdfs:label "positive regulation of smooth muscle hypertrophy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of membrane invagination) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:26589353") "Any process that modulates the frequency, rate or extent of membrane invagination.") AnnotationAssertion(rdfs:label "regulation of membrane invagination") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of membrane invagination) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:26589353") "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination.") AnnotationAssertion(rdfs:label "negative regulation of membrane invagination") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of membrane invagination) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") "Any process that activates or increases the frequency, rate or extent of membrane invagination.") AnnotationAssertion(rdfs:label "positive regulation of membrane invagination") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of lysosomal protein catabolic process) + +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:23499937") "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process.") +AnnotationAssertion(rdfs:label "regulation of lysosomal protein catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of lysosomal protein catabolic process) + +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process.") +AnnotationAssertion(rdfs:label "negative regulation of lysosomal protein catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of lysosomal protein catabolic process) + +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process.") +AnnotationAssertion(rdfs:label "positive regulation of lysosomal protein catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of cardiocyte differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:23069713") "Any process that modulates the frequency, rate or extent of cardiocyte differentiation.") AnnotationAssertion(rdfs:label "regulation of cardiocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiocyte differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:23069713") "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation.") AnnotationAssertion(rdfs:label "negative regulation of cardiocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of cardiocyte differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:23069713") "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation.") AnnotationAssertion(rdfs:label "positive regulation of cardiocyte differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of mitotic chromosome condensation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:23219725") "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation.") AnnotationAssertion(rdfs:label "negative regulation of mitotic chromosome condensation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (epicardium morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000083") Annotation( "PMID:18718461") "The developmental process by which an epicardium is generated and organized.") AnnotationAssertion(rdfs:label "epicardium morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of chromatin organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") Annotation( "GOC:vw") Annotation( "GO_REF:0000058") Annotation( "PMID:654321") "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization.") AnnotationAssertion(rdfs:label "negative regulation of chromatin organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of chromatin organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:pr") Annotation( "GOC:vw") Annotation( "GO_REF:0000058") Annotation( "PMID:654321") "Any process that activates or increases the frequency, rate or extent of chromatin organization.") AnnotationAssertion(rdfs:label "positive regulation of chromatin organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of epithelial tube formation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "GO_REF:0000058") Annotation( "PMID:25745997") "Any process that modulates the frequency, rate or extent of epithelial tube formation.") +AnnotationAssertion(rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).") AnnotationAssertion(rdfs:label "regulation of epithelial tube formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -27465,6 +36444,8 @@ SubClassOf( (negative regulation of epithelial tube formation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "GO_REF:0000058") Annotation( "PMID:25745997") "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation.") +AnnotationAssertion(rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).") AnnotationAssertion(rdfs:label "negative regulation of epithelial tube formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -27473,6 +36454,8 @@ SubClassOf( (positive regulation of epithelial tube formation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "GO_REF:0000058") Annotation( "PMID:25745997") "Any process that activates or increases the frequency, rate or extent of epithelial tube formation.") +AnnotationAssertion(rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).") AnnotationAssertion(rdfs:label "positive regulation of epithelial tube formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -27481,91 +36464,132 @@ SubClassOf( (vascular associated smooth muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000085") Annotation( "PMID:26493107") "Any apoptotic process in a vascular associated smooth muscle cell.") AnnotationAssertion(rdfs:label "vascular associated smooth muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of neural crest cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:15073157") "Any process that modulates the frequency, rate or extent of neural crest cell differentiation.") AnnotationAssertion(rdfs:label "regulation of neural crest cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of neural crest cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:15073157") "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of neural crest cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of neural crest cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:15073157") "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of neural crest cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (regulation of intestinal epithelial cell development) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:23904268") "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development.") +AnnotationAssertion(rdfs:label "regulation of intestinal epithelial cell development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (negative regulation of intestinal epithelial cell development) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:23904268") "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development.") +AnnotationAssertion(rdfs:label "negative regulation of intestinal epithelial cell development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (positive regulation of intestinal epithelial cell development) + +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:23904268") "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development.") +AnnotationAssertion(rdfs:label "positive regulation of intestinal epithelial cell development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (regulation of cardiac myofibril assembly) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:16151019") "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly.") AnnotationAssertion(rdfs:label "regulation of cardiac myofibril assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of cardiac myofibril assembly) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:16151019") "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly.") AnnotationAssertion(rdfs:label "negative regulation of cardiac myofibril assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of cardiac myofibril assembly) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:16151019") "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly.") AnnotationAssertion(rdfs:label "positive regulation of cardiac myofibril assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:17628518") "Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.") AnnotationAssertion(rdfs:label "regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:17628518") "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:17628518") "Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.") AnnotationAssertion(rdfs:label "positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cell proliferation involved in endocardial cushion morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000060") Annotation( "PMID:20652948") "Any cell proliferation that is involved in endocardial cushion morphogenesis.") AnnotationAssertion(rdfs:label "cell proliferation involved in endocardial cushion morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (mesenchymal stem cell migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000091") Annotation( "PMID:24924806") Annotation( "PMID:25181476") "The orderly movement of a mesenchymal stem cell from one site to another.") AnnotationAssertion(rdfs:label "mesenchymal stem cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of mesenchymal stem cell migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:26846297") "Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration.") AnnotationAssertion(rdfs:label "regulation of mesenchymal stem cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of mesenchymal stem cell migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:26846297") "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration.") AnnotationAssertion(rdfs:label "negative regulation of mesenchymal stem cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of mesenchymal stem cell migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:26846297") "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration.") AnnotationAssertion(rdfs:label "positive regulation of mesenchymal stem cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of morphogenesis of an epithelium) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "GO_REF:0000058") Annotation( "PMID:25745997") "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium.") +AnnotationAssertion(rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).") AnnotationAssertion(rdfs:label "regulation of morphogenesis of an epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of morphogenesis of an epithelium) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "GO_REF:0000058") Annotation( "PMID:25745997") "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium.") +AnnotationAssertion(rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).") AnnotationAssertion(rdfs:label "negative regulation of morphogenesis of an epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -27573,6 +36597,8 @@ SubClassOf( (positive regulation of morphogenesis of an epithelium) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "GO_REF:0000058") Annotation( "PMID:25745997") "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium.") +AnnotationAssertion(rdfs:comment "An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).") AnnotationAssertion(rdfs:label "positive regulation of morphogenesis of an epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -27580,172 +36606,206 @@ SubClassOf( (ciliary transition zone assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GO_REF:0000079") Annotation( "PMID:21725307") Annotation( "PMID:23644468") Annotation( "PMID:24448408") Annotation( "PMID:26595381") Annotation( "PMID:26982032") "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone.") AnnotationAssertion(rdfs:label "ciliary transition zone assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (pericyte cell migration) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000091") Annotation( "PMID:26268439") "The orderly movement of a pericyte cell from one site to another.") AnnotationAssertion(rdfs:label "pericyte cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to presynapse) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000087") Annotation( "PMID:24449494") "A process in which a protein is transported to, or maintained in, a location within a presynapse.") AnnotationAssertion(rdfs:label "protein localization to presynapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of protein localization to presynapse) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:24449494") "Any process that modulates the frequency, rate or extent of protein localization to presynapse.") AnnotationAssertion(rdfs:label "regulation of protein localization to presynapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to presynapse) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:24449494") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to presynapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to presynapse) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:24449494") "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to presynapse") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of retrograde trans-synaptic signaling by neuropeptide) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:19448629") "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.") AnnotationAssertion(rdfs:label "regulation of retrograde trans-synaptic signaling by neuropeptide") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of retrograde trans-synaptic signaling by neuropeptide) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:19448629") "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.") AnnotationAssertion(rdfs:label "negative regulation of retrograde trans-synaptic signaling by neuropeptide") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of retrograde trans-synaptic signaling by neuropeptide) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GO_REF:0000058") Annotation( "PMID:19448629") "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.") AnnotationAssertion(rdfs:label "positive regulation of retrograde trans-synaptic signaling by neuropeptide") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of myeloid progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:27010503") "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation.") AnnotationAssertion(rdfs:label "regulation of myeloid progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myeloid progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:27010503") "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of myeloid progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myeloid progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:27010503") "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of myeloid progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of lymphoid progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:27010503") "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation.") AnnotationAssertion(rdfs:label "regulation of lymphoid progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of lymphoid progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:27010503") "Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of lymphoid progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of lymphoid progenitor cell differentiation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:27010503") "Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of lymphoid progenitor cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of vascular associated smooth muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:26493107") "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.") AnnotationAssertion(rdfs:label "regulation of vascular associated smooth muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of vascular associated smooth muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:26493107") "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of vascular associated smooth muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of vascular associated smooth muscle cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:26493107") "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of vascular associated smooth muscle cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of protein localization to membrane) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:26911690") "Any process that modulates the frequency, rate or extent of protein localization to membrane.") AnnotationAssertion(rdfs:label "regulation of protein localization to membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to membrane) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:26911690") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to membrane) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:26911690") "Any process that activates or increases the frequency, rate or extent of protein localization to membrane.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of motor neuron migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:16516839") "Any process that modulates the frequency, rate or extent of motor neuron migration.") AnnotationAssertion(rdfs:label "regulation of motor neuron migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of motor neuron migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:16516839") "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration.") AnnotationAssertion(rdfs:label "negative regulation of motor neuron migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of motor neuron migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:16516839") "Any process that activates or increases the frequency, rate or extent of motor neuron migration.") AnnotationAssertion(rdfs:label "positive regulation of motor neuron migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of branching morphogenesis of a nerve) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:16516839") "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve.") AnnotationAssertion(rdfs:label "positive regulation of branching morphogenesis of a nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of motile cilium assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000058") Annotation( "PMID:25294941") "Any process that modulates the frequency, rate or extent of motile cilium assembly.") AnnotationAssertion(rdfs:label "regulation of motile cilium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of motile cilium assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000058") Annotation( "PMID:25294941") "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly.") AnnotationAssertion(rdfs:label "negative regulation of motile cilium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of motile cilium assembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000058") Annotation( "PMID:25294941") "Any process that activates or increases the frequency, rate or extent of motile cilium assembly.") AnnotationAssertion(rdfs:label "positive regulation of motile cilium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of fertilization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:hbye") Annotation( "GO_REF:0000058") Annotation( "PMID:27564576") "Any process that activates or increases the frequency, rate or extent of fertilization.") AnnotationAssertion(rdfs:label "positive regulation of fertilization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (macrophage migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000091") Annotation( "PMID:25749876") "The orderly movement of a macrophage from one site to another.") AnnotationAssertion(rdfs:label "macrophage migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of macrophage migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25749876") "Any process that modulates the frequency, rate or extent of macrophage migration.") AnnotationAssertion(rdfs:label "regulation of macrophage migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of macrophage migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25749876") "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration.") AnnotationAssertion(rdfs:label "negative regulation of macrophage migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of macrophage migration) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25749876") "Any process that activates or increases the frequency, rate or extent of macrophage migration.") AnnotationAssertion(rdfs:label "positive regulation of macrophage migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of blood vessel branching) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_telomere") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:23201774") "Any process that modulates the frequency, rate or extent of blood vessel branching.") AnnotationAssertion(rdfs:label "regulation of blood vessel branching") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -27754,6 +36814,7 @@ SubClassOf( (negative regulation of vessel branching) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_telomere") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:23201774") "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching.") AnnotationAssertion(rdfs:label "negative regulation of vessel branching") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -27762,6 +36823,7 @@ SubClassOf( (positive regulation of blood vessel branching) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_telomere") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:23201774") "Any process that activates or increases the frequency, rate or extent of blood vessel branching.") AnnotationAssertion(rdfs:label "positive regulation of blood vessel branching") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -27770,313 +36832,372 @@ SubClassOf( (regulation of mitotic nuclear envelope disassembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:18765790") "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly.") AnnotationAssertion(rdfs:label "regulation of mitotic nuclear envelope disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of mitotic nuclear envelope disassembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:18765790") "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly.") AnnotationAssertion(rdfs:label "negative regulation of mitotic nuclear envelope disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of mitotic nuclear envelope disassembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:18765790") "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly.") AnnotationAssertion(rdfs:label "positive regulation of mitotic nuclear envelope disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of vascular endothelial cell proliferation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_telomere") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:23201774") "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation.") AnnotationAssertion(rdfs:label "regulation of vascular endothelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of vascular endothelial cell proliferation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_telomere") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:23201774") "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of vascular endothelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of vascular endothelial cell proliferation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_telomere") Annotation( "GOC:TermGenie") Annotation( "GOC:nc") Annotation( "GO_REF:0000058") Annotation( "PMID:23201774") "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of vascular endothelial cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of presynapse assembly) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:25533483") "Any process that modulates the frequency, rate or extent of presynapse assembly.") AnnotationAssertion(rdfs:label "regulation of presynapse assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of presynapse assembly) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:25533483") "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly.") AnnotationAssertion(rdfs:label "negative regulation of presynapse assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of presynapse assembly) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000058") Annotation( "PMID:25533483") "Any process that activates or increases the frequency, rate or extent of presynapse assembly.") AnnotationAssertion(rdfs:label "positive regulation of presynapse assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of serotonin biosynthetic process) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:pad") Annotation( "GO_REF:0000058") Annotation( "PMID:25642596") "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process.") AnnotationAssertion(rdfs:label "regulation of serotonin biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of serotonin biosynthetic process) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:pad") Annotation( "GO_REF:0000058") Annotation( "PMID:25642596") "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process.") AnnotationAssertion(rdfs:label "negative regulation of serotonin biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of serotonin biosynthetic process) +AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:pad") Annotation( "GO_REF:0000058") Annotation( "PMID:25642596") "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process.") AnnotationAssertion(rdfs:label "positive regulation of serotonin biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to euchromatin) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000087") Annotation( "PMID:20889714") "A process in which a protein is transported to, or maintained in, a location within an euchromatin.") AnnotationAssertion(rdfs:label "protein localization to euchromatin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (establishment of protein localization to euchromatin) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000087") Annotation( "PMID:20889714") "The directed movement of a protein to a specific location in an euchromatin.") AnnotationAssertion(rdfs:label "establishment of protein localization to euchromatin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of protein localization to chromatin) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:20889714") "Any process that modulates the frequency, rate or extent of protein localization to chromatin.") AnnotationAssertion(rdfs:label "regulation of protein localization to chromatin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of artery morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:27389411") "Any process that modulates the frequency, rate or extent of artery morphogenesis.") AnnotationAssertion(rdfs:label "regulation of artery morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of artery morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:27389411") "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of artery morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of artery morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:27389411") "Any process that activates or increases the frequency, rate or extent of artery morphogenesis.") AnnotationAssertion(rdfs:label "positive regulation of artery morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of lysosome organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25561470") "Any process that modulates the frequency, rate or extent of lysosome organization.") AnnotationAssertion(rdfs:label "regulation of lysosome organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of lysosome organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25561470") "Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization.") AnnotationAssertion(rdfs:label "negative regulation of lysosome organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of lysosome organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25561470") "Any process that activates or increases the frequency, rate or extent of lysosome organization.") AnnotationAssertion(rdfs:label "positive regulation of lysosome organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (nucleus disassembly) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:autophagy") Annotation( "GOC:pr") Annotation( "GO_REF:0000079") "The disaggregation of a nucleus into its constituent components.") AnnotationAssertion(rdfs:label "nucleus disassembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (cytoplasmic microtubule bundle) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000064") Annotation( "PMID:11007487") Annotation( "PMID:26124291") "Any microtubule bundle that is part of a cytoplasm.") AnnotationAssertion(rdfs:label "cytoplasmic microtubule bundle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (protein localization to cytoplasmic microtubule) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000087") Annotation( "PMID:15177031") "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule.") AnnotationAssertion(rdfs:label "protein localization to cytoplasmic microtubule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of mesodermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:23765923") "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation.") AnnotationAssertion(rdfs:label "regulation of mesodermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of mesodermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:23765923") "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of mesodermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of mesodermal cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:23765923") "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of mesodermal cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of synapse pruning) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:27779093") "Any process that modulates the frequency, rate or extent of synapse pruning.") AnnotationAssertion(rdfs:label "regulation of synapse pruning") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of synapse pruning) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:27779093") "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning.") AnnotationAssertion(rdfs:label "negative regulation of synapse pruning") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of synapse pruning) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:27779093") "Any process that activates or increases the frequency, rate or extent of synapse pruning.") AnnotationAssertion(rdfs:label "positive regulation of synapse pruning") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of synapse organization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:27779093") "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization.") AnnotationAssertion(rdfs:label "negative regulation of synapse organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of chromosome condensation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "GO_REF:0000058") Annotation( "PMID:17268547") "Any process that activates or increases the frequency, rate or extent of chromosome condensation.") AnnotationAssertion(rdfs:label "positive regulation of chromosome condensation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of microtubule nucleation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:27689799") "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation.") AnnotationAssertion(rdfs:label "negative regulation of microtubule nucleation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of protein localization to cell leading edge) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:26324884") "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge.") AnnotationAssertion(rdfs:label "regulation of protein localization to cell leading edge") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of protein localization to cell leading edge) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:26324884") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge.") AnnotationAssertion(rdfs:label "negative regulation of protein localization to cell leading edge") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of protein localization to cell leading edge) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:26324884") "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge.") AnnotationAssertion(rdfs:label "positive regulation of protein localization to cell leading edge") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of oogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:26434723") "Any process that modulates the frequency, rate or extent of oogenesis.") AnnotationAssertion(rdfs:label "regulation of oogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of oogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:26434723") "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis.") AnnotationAssertion(rdfs:label "negative regulation of oogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of oogenesis) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:26434723") "Any process that activates or increases the frequency, rate or extent of oogenesis.") AnnotationAssertion(rdfs:label "positive regulation of oogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of smooth muscle tissue development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "GO_REF:0000058") Annotation( "PMID:14709716") "Any process that modulates the frequency, rate or extent of smooth muscle tissue development.") AnnotationAssertion(rdfs:label "regulation of smooth muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of smooth muscle tissue development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "GO_REF:0000058") Annotation( "PMID:14709716") "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development.") AnnotationAssertion(rdfs:label "negative regulation of smooth muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of smooth muscle tissue development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bhm") Annotation( "GO_REF:0000058") Annotation( "PMID:14709716") "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development.") AnnotationAssertion(rdfs:label "positive regulation of smooth muscle tissue development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of mesoderm formation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:23939491") "Any process that modulates the frequency, rate or extent of mesoderm formation.") AnnotationAssertion(rdfs:label "regulation of mesoderm formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of mesoderm formation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:23939491") "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation.") AnnotationAssertion(rdfs:label "negative regulation of mesoderm formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of mesoderm formation) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:23939491") "Any process that activates or increases the frequency, rate or extent of mesoderm formation.") AnnotationAssertion(rdfs:label "positive regulation of mesoderm formation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of germ cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:15342467") "Any process that modulates the frequency, rate or extent of germ cell proliferation.") AnnotationAssertion(rdfs:label "regulation of germ cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of germ cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:15342467") "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of germ cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of germ cell proliferation) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:15342467") "Any process that activates or increases the frequency, rate or extent of germ cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of germ cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of gonad development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:15342467") "Any process that modulates the frequency, rate or extent of gonad development.") AnnotationAssertion(rdfs:label "regulation of gonad development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of gonad development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:15342467") "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development.") AnnotationAssertion(rdfs:label "negative regulation of gonad development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of gonad development) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:15342467") "Any process that activates or increases the frequency, rate or extent of gonad development.") AnnotationAssertion(rdfs:label "positive regulation of gonad development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of lipid localization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17564681") "Any process that modulates the frequency, rate or extent of lipid localization.") AnnotationAssertion(rdfs:label "regulation of lipid localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of lipid localization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17564681") "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization.") AnnotationAssertion(rdfs:label "negative regulation of lipid localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of lipid localization) +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:17564681") "Any process that activates or increases the frequency, rate or extent of lipid localization.") AnnotationAssertion(rdfs:label "positive regulation of lipid localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of endothelial tube morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:25961718") "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of endothelial tube morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of endothelial tube morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:25961718") "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis.") AnnotationAssertion(rdfs:label "positive regulation of endothelial tube morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (retinal cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:15558487") Annotation( "PMID:24664675") "Any apoptotic process in a retinal cell.") AnnotationAssertion(rdfs:label "retinal cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (compound eye retinal cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:12021768") "Any apoptotic process in a compound eye retinal cell.") AnnotationAssertion(rdfs:label "compound eye retinal cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (exosomal secretion) +AnnotationAssertion(Annotation( "GOC:hjd") Annotation( "PMID:10572093") Annotation( "PMID:12154376") Annotation( "PMID:16773132") Annotation( "PMID:18617898") "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.") AnnotationAssertion(rdfs:label "exosomal secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28087,41 +37208,98 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (RNA localization to chromatin) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:mah") Annotation( "PMID:22582262") "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin.") AnnotationAssertion(rdfs:label "RNA localization to chromatin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (transporter complex) + +AnnotationAssertion(Annotation( "GOC:bhm") Annotation( "PMID:15449578") "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells.") +AnnotationAssertion(rdfs:comment "An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay).") +AnnotationAssertion(rdfs:label "transporter complex") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (dense core granule maturation) +AnnotationAssertion(Annotation( "GOC:kmv") Annotation( "PMID:22654674") "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis.") AnnotationAssertion(rdfs:label "dense core granule maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (cholangiocyte proliferation) + +AnnotationAssertion(Annotation( "PMID:24434010") "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water.") +AnnotationAssertion(rdfs:label "cholangiocyte proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (cellular detoxification) + +AnnotationAssertion(Annotation( "GOC:vw") "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.") +AnnotationAssertion(rdfs:label "cellular detoxification") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (colon smooth muscle contraction) + +AnnotationAssertion(Annotation( "PMID:24170253") "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum.") +AnnotationAssertion(rdfs:label "colon smooth muscle contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) + # Class: (gastric mucosal blood circulation) +AnnotationAssertion(Annotation( "PMID:10807413") "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products.") AnnotationAssertion(rdfs:label "gastric mucosal blood circulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (small intestine smooth muscle contraction) + +AnnotationAssertion(Annotation( "PMID:11991626") "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine.") +AnnotationAssertion(rdfs:label "small intestine smooth muscle contraction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) + # Class: (protein localization to cell periphery) +AnnotationAssertion(Annotation( "PMID:18216290") "A process in which a protein is transported to, or maintained in, the cell periphery.") AnnotationAssertion(rdfs:label "protein localization to cell periphery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (vacuolar localization) +AnnotationAssertion(Annotation( "PMID:26283797") "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell.") AnnotationAssertion(rdfs:label "vacuolar localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (acinar cell proliferation) + +AnnotationAssertion(Annotation( "PMID:9788538") "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus).") +AnnotationAssertion(rdfs:label "acinar cell proliferation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (vascular associated smooth muscle cell proliferation) +AnnotationAssertion(Annotation( "PMID:23246467") "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.") AnnotationAssertion(rdfs:label "vascular associated smooth muscle cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (ribonucleoprotein complex) +AnnotationAssertion(Annotation( "GOC:krc") Annotation( "GOC:vesicles") "A macromolecular complex that contains both RNA and protein molecules.") +AnnotationAssertion( "Wikipedia:Ribonucleoprotein") AnnotationAssertion(rdfs:label "ribonucleoprotein complex") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -28129,6 +37307,7 @@ SubClassOf( ObjectSomeValuesFrom( (ooplasm) +AnnotationAssertion(Annotation( "PMID:19022436") "The cytoplasm of an ovum.") AnnotationAssertion(rdfs:label "ooplasm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28138,6 +37317,7 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (regulation of multicellular organismal development) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of multicellular organismal development.") AnnotationAssertion(rdfs:label "regulation of multicellular organismal development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28145,138 +37325,185 @@ SubClassOf( (regulation of animal organ morphogenesis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of animal organ morphogenesis.") AnnotationAssertion(rdfs:label "regulation of animal organ morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of stem cell division) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of stem cell division.") AnnotationAssertion(rdfs:label "regulation of stem cell division") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (regulation of defense response to insect) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of defense response to insect.") AnnotationAssertion(rdfs:label "regulation of defense response to insect") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of type B pancreatic cell development) + +AnnotationAssertion(Annotation( "GOC:obol") Annotation( "GOC:yaf") "Any process that modulates the frequency, rate or extent of pancreatic B cell development.") +AnnotationAssertion(rdfs:label "regulation of type B pancreatic cell development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of type B pancreatic cell development) + +AnnotationAssertion(Annotation( "GOC:obol") Annotation( "GOC:yaf") "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development.") +AnnotationAssertion(rdfs:label "negative regulation of type B pancreatic cell development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (positive regulation of type B pancreatic cell development) + +AnnotationAssertion(Annotation( "GOC:obol") Annotation( "GOC:yaf") "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development.") +AnnotationAssertion(rdfs:label "positive regulation of type B pancreatic cell development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (regulation of leukocyte apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process.") AnnotationAssertion(rdfs:label "regulation of leukocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of leukocyte apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of leukocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of leukocyte apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of leukocyte apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of macrophage apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") "Any process that modulates the frequency, rate or extent of macrophage apoptotic process.") AnnotationAssertion(rdfs:label "regulation of macrophage apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of macrophage apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of macrophage apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of macrophage apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_apoptosis") "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of macrophage apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of establishment of cell polarity) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the frequency, rate or extent of establishment of cell polarity.") AnnotationAssertion(rdfs:label "regulation of establishment of cell polarity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cell proliferation involved in heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis.") AnnotationAssertion(rdfs:label "regulation of cell proliferation involved in heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cell proliferation involved in heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of cell proliferation involved in heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cell proliferation involved in heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis.") AnnotationAssertion(rdfs:label "positive regulation of cell proliferation involved in heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cell motility) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of cell motility.") AnnotationAssertion(rdfs:label "regulation of cell motility") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of cell motility) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.") AnnotationAssertion(rdfs:label "negative regulation of cell motility") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of cell motility) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of cell motility.") AnnotationAssertion(rdfs:label "positive regulation of cell motility") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (positive regulation of cilium-dependent cell motility) +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:jl") "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility.") AnnotationAssertion(rdfs:label "positive regulation of cilium-dependent cell motility") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of branching morphogenesis of a nerve) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve.") AnnotationAssertion(rdfs:label "regulation of branching morphogenesis of a nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of branching morphogenesis of a nerve) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve.") AnnotationAssertion(rdfs:label "negative regulation of branching morphogenesis of a nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of pro-T cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that modulates the frequency, rate or extent of pro-T cell differentiation.") AnnotationAssertion(rdfs:label "regulation of pro-T cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of pro-T cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of pro-T cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of pro-T cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of pro-T cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of neural precursor cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation.") AnnotationAssertion(rdfs:label "regulation of neural precursor cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of neural precursor cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of neural precursor cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of neural precursor cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of neural precursor cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of blood vessel morphogenesis) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:yaf") "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of blood vessel morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28284,6 +37511,7 @@ SubClassOf( (regulation of female gonad development) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of female gonad development.") AnnotationAssertion(rdfs:label "regulation of female gonad development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28291,6 +37519,7 @@ SubClassOf( (negative regulation of female gonad development) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.") AnnotationAssertion(rdfs:label "negative regulation of female gonad development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28300,6 +37529,7 @@ SubClassOf( (positive regulation of female gonad development) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of female gonad development.") AnnotationAssertion(rdfs:label "positive regulation of female gonad development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28307,14 +37537,36 @@ SubClassOf( ) SubClassOf( ) +# Class: (regulation of pancreatic A cell differentiation) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation.") +AnnotationAssertion(rdfs:label "regulation of pancreatic A cell differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of pancreatic A cell differentiation) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation.") +AnnotationAssertion(rdfs:label "negative regulation of pancreatic A cell differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (positive regulation of pancreatic A cell differentiation) + +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation.") +AnnotationAssertion(rdfs:label "positive regulation of pancreatic A cell differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (regulation of reproductive process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of reproductive process.") AnnotationAssertion(rdfs:label "regulation of reproductive process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of reproductive process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process.") AnnotationAssertion(rdfs:label "negative regulation of reproductive process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28322,6 +37574,7 @@ SubClassOf( (positive regulation of reproductive process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of reproductive process.") AnnotationAssertion(rdfs:label "positive regulation of reproductive process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28329,6 +37582,7 @@ SubClassOf( (negative regulation of establishment or maintenance of neuroblast polarity) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity.") AnnotationAssertion(rdfs:label "negative regulation of establishment or maintenance of neuroblast polarity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -28336,87 +37590,129 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of fibroblast apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") Annotation( "GOC:yaf") "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process.") AnnotationAssertion(rdfs:label "regulation of fibroblast apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of fibroblast apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") Annotation( "GOC:yaf") "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of fibroblast apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of fibroblast apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") Annotation( "GOC:yaf") "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of fibroblast apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of DNA biosynthetic process) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of DNA biosynthetic process.") AnnotationAssertion(rdfs:label "regulation of DNA biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of DNA biosynthetic process) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.") AnnotationAssertion(rdfs:label "negative regulation of DNA biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myotome development) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that activates or increases the frequency, rate or extent of myotome development.") AnnotationAssertion(rdfs:label "positive regulation of myotome development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myoblast proliferation) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that activates or increases the frequency, rate or extent of myoblast proliferation.") AnnotationAssertion(rdfs:label "positive regulation of myoblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of myotome development) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of myotome development.") AnnotationAssertion(rdfs:label "regulation of myotome development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of myoblast proliferation) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of myoblast proliferation.") AnnotationAssertion(rdfs:label "regulation of myoblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of defecation) + +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of defecation.") +AnnotationAssertion(rdfs:label "regulation of defecation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (negative regulation of defecation) + +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of defecation.") +AnnotationAssertion(rdfs:label "negative regulation of defecation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (positive regulation of defecation) + +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of defecation.") +AnnotationAssertion(rdfs:label "positive regulation of defecation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (regulation of endothelial cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process.") AnnotationAssertion(rdfs:label "regulation of endothelial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of endothelial cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of endothelial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of endothelial cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of endothelial cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of oxygen metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of oxygen metabolic process.") AnnotationAssertion(rdfs:label "regulation of oxygen metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of oxygen metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process.") AnnotationAssertion(rdfs:label "negative regulation of oxygen metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of oxygen metabolic process) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process.") AnnotationAssertion(rdfs:label "positive regulation of oxygen metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of mesoderm development) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that modulates the frequency, rate or extent of mesoderm development.") AnnotationAssertion(rdfs:label "regulation of mesoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of mesoderm development) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.") AnnotationAssertion(rdfs:label "negative regulation of mesoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28424,6 +37720,7 @@ SubClassOf( (positive regulation of mesoderm development) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that activates or increases the frequency, rate or extent of mesoderm development.") AnnotationAssertion(rdfs:label "positive regulation of mesoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28431,12 +37728,14 @@ SubClassOf( (regulation of ectoderm development) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that modulates the frequency, rate or extent of ectoderm development.") AnnotationAssertion(rdfs:label "regulation of ectoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) # Class: (negative regulation of ectoderm development) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development.") AnnotationAssertion(rdfs:label "negative regulation of ectoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28444,6 +37743,7 @@ SubClassOf( (positive regulation of ectoderm development) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that activates or increases the frequency, rate or extent of ectoderm development.") AnnotationAssertion(rdfs:label "positive regulation of ectoderm development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28451,96 +37751,115 @@ SubClassOf( (regulation of lymphocyte migration) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of lymphocyte migration.") AnnotationAssertion(rdfs:label "regulation of lymphocyte migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of lymphocyte migration) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration.") AnnotationAssertion(rdfs:label "negative regulation of lymphocyte migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of lymphocyte migration) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of lymphocyte migration.") AnnotationAssertion(rdfs:label "positive regulation of lymphocyte migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of T cell migration) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of T cell migration.") AnnotationAssertion(rdfs:label "regulation of T cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of T cell migration) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration.") AnnotationAssertion(rdfs:label "negative regulation of T cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of T cell migration) +AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of T cell migration.") AnnotationAssertion(rdfs:label "positive regulation of T cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of hematopoietic stem cell migration) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration.") AnnotationAssertion(rdfs:label "regulation of hematopoietic stem cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of hematopoietic stem cell migration) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration.") AnnotationAssertion(rdfs:label "negative regulation of hematopoietic stem cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of hematopoietic stem cell migration) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.") AnnotationAssertion(rdfs:label "positive regulation of hematopoietic stem cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cell proliferation involved in compound eye morphogenesis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.") AnnotationAssertion(rdfs:label "regulation of cell proliferation involved in compound eye morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cell proliferation involved in compound eye morphogenesis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of cell proliferation involved in compound eye morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cell proliferation involved in compound eye morphogenesis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.") AnnotationAssertion(rdfs:label "positive regulation of cell proliferation involved in compound eye morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of dendritic cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis.") AnnotationAssertion(rdfs:label "regulation of dendritic cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of dendritic cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis.") AnnotationAssertion(rdfs:label "negative regulation of dendritic cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of dendritic cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.") AnnotationAssertion(rdfs:label "positive regulation of dendritic cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of myeloid dendritic cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis.") AnnotationAssertion(rdfs:label "regulation of myeloid dendritic cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myeloid dendritic cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis.") AnnotationAssertion(rdfs:label "negative regulation of myeloid dendritic cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of myeloid dendritic cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis.") AnnotationAssertion(rdfs:label "positive regulation of myeloid dendritic cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of gastrulation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation.") AnnotationAssertion(rdfs:label "negative regulation of gastrulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28548,6 +37867,7 @@ SubClassOf( (positive regulation of gastrulation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of gastrulation.") AnnotationAssertion(rdfs:label "positive regulation of gastrulation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28555,116 +37875,157 @@ SubClassOf( (regulation of dendritic cell dendrite assembly) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly.") AnnotationAssertion(rdfs:label "regulation of dendritic cell dendrite assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of dendritic cell dendrite assembly) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly.") AnnotationAssertion(rdfs:label "negative regulation of dendritic cell dendrite assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of dendritic cell dendrite assembly) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly.") AnnotationAssertion(rdfs:label "positive regulation of dendritic cell dendrite assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of DNA biosynthetic process) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.") AnnotationAssertion(rdfs:label "positive regulation of DNA biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of stem cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.") AnnotationAssertion(rdfs:label "negative regulation of stem cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of stem cell proliferation) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that activates or increases the frequency, rate or extent of stem cell proliferation.") AnnotationAssertion(rdfs:label "positive regulation of stem cell proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of dendritic cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process.") AnnotationAssertion(rdfs:label "regulation of dendritic cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of dendritic cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of dendritic cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of dendritic cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of dendritic cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of motor neuron apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process.") AnnotationAssertion(rdfs:label "regulation of motor neuron apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of motor neuron apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of motor neuron apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of motor neuron apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of motor neuron apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (regulation of type B pancreatic cell apoptotic process) + +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process.") +AnnotationAssertion(rdfs:label "regulation of type B pancreatic cell apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (negative regulation of type B pancreatic cell apoptotic process) + +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.") +AnnotationAssertion(rdfs:label "negative regulation of type B pancreatic cell apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (positive regulation of type B pancreatic cell apoptotic process) + +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process.") +AnnotationAssertion(rdfs:label "positive regulation of type B pancreatic cell apoptotic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of cardiac muscle cell myoblast differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle cell myoblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac muscle cell myoblast differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation.") AnnotationAssertion(rdfs:label "negative regulation of cardiac muscle cell myoblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardiac muscle cell myoblast differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation.") AnnotationAssertion(rdfs:label "positive regulation of cardiac muscle cell myoblast differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of cardiac muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation.") AnnotationAssertion(rdfs:label "regulation of cardiac muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of cardiac muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of cardiac muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of cardiac muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of cardiac muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of stem cell differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of stem cell differentiation.") AnnotationAssertion(rdfs:label "regulation of stem cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of stem cell differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of stem cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of stem cell differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of stem cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of stem cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of mesenchymal cell proliferation involved in lung development) +AnnotationAssertion(Annotation( "PMID:21513708") "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.") AnnotationAssertion(rdfs:label "regulation of mesenchymal cell proliferation involved in lung development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of mesenchymal cell proliferation involved in lung development) +AnnotationAssertion(Annotation( "PMID:21513708") "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.") AnnotationAssertion(rdfs:label "negative regulation of mesenchymal cell proliferation involved in lung development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -28672,6 +38033,7 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of mesenchymal cell proliferation involved in lung development) +AnnotationAssertion(Annotation( "PMID:21513708") "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.") AnnotationAssertion(rdfs:label "positive regulation of mesenchymal cell proliferation involved in lung development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -28679,26 +38041,31 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of epithelial cell proliferation involved in lung morphogenesis) +AnnotationAssertion(Annotation( "PMID:21513708") "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.") AnnotationAssertion(rdfs:label "regulation of epithelial cell proliferation involved in lung morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of epithelial cell proliferation involved in lung morphogenesis) +AnnotationAssertion(Annotation( "PMID:21513708") "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.") AnnotationAssertion(rdfs:label "negative regulation of epithelial cell proliferation involved in lung morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of myoblast proliferation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation.") AnnotationAssertion(rdfs:label "negative regulation of myoblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of heart morphogenesis) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that modulates the frequency, rate or extent of heart morphogenesis.") AnnotationAssertion(rdfs:label "regulation of heart morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of steroid hormone secretion) +AnnotationAssertion(Annotation( "GOC:sl") "Any process that modulates the frequency, rate or extent of steroid hormone secretion.") AnnotationAssertion(rdfs:label "regulation of steroid hormone secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28707,6 +38074,7 @@ SubClassOf( (negative regulation of steroid hormone secretion) +AnnotationAssertion(Annotation( "GOC:sl") "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion.") AnnotationAssertion(rdfs:label "negative regulation of steroid hormone secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28716,6 +38084,7 @@ SubClassOf( (positive regulation of steroid hormone secretion) +AnnotationAssertion(Annotation( "GOC:sl") "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion.") AnnotationAssertion(rdfs:label "positive regulation of steroid hormone secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -28725,118 +38094,147 @@ SubClassOf( (regulation of androgen secretion) +AnnotationAssertion(Annotation( "GOC:sl") "Any process that modulates the frequency, rate or extent of androgen secretion.") AnnotationAssertion(rdfs:label "regulation of androgen secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of androgen secretion) +AnnotationAssertion(Annotation( "GOC:sl") "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion.") AnnotationAssertion(rdfs:label "negative regulation of androgen secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of androgen secretion) +AnnotationAssertion(Annotation( "GOC:sl") "Any process that activates or increases the frequency, rate or extent of androgen secretion.") AnnotationAssertion(rdfs:label "positive regulation of androgen secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (mesenchymal cell differentiation involved in renal system development) + +AnnotationAssertion(Annotation( "GOC:mtg_kidney_jan10") Annotation( "GOC:obol") Annotation( "GOC:yaf") "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state.") +AnnotationAssertion(rdfs:label "mesenchymal cell differentiation involved in renal system development") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of skeletal muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.") AnnotationAssertion(rdfs:label "regulation of skeletal muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of skeletal muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of skeletal muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of skeletal muscle cell differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of skeletal muscle cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of endothelial cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis.") AnnotationAssertion(rdfs:label "regulation of endothelial cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of endothelial cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis.") AnnotationAssertion(rdfs:label "negative regulation of endothelial cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of endothelial cell chemotaxis) +AnnotationAssertion(Annotation( "GOC:BHF") "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.") AnnotationAssertion(rdfs:label "positive regulation of endothelial cell chemotaxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of mesenchymal cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process.") AnnotationAssertion(rdfs:label "regulation of mesenchymal cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of mesenchymal cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process.") AnnotationAssertion(rdfs:label "negative regulation of mesenchymal cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of mesenchymal cell apoptotic process) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process.") AnnotationAssertion(rdfs:label "positive regulation of mesenchymal cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of RNA biosynthetic process) +AnnotationAssertion(Annotation( "GOC:dph") "Any process that modulates the frequency, rate or extent of RNA biosynthetic process.") AnnotationAssertion(rdfs:label "regulation of RNA biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of dendritic cell differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of dendritic cell differentiation.") AnnotationAssertion(rdfs:label "regulation of dendritic cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of dendritic cell differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.") AnnotationAssertion(rdfs:label "negative regulation of dendritic cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of dendritic cell differentiation) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation.") AnnotationAssertion(rdfs:label "positive regulation of dendritic cell differentiation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of osteoclast development) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of osteoclast development.") AnnotationAssertion(rdfs:label "regulation of osteoclast development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of osteoclast development) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.") AnnotationAssertion(rdfs:label "negative regulation of osteoclast development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of osteoclast development) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of osteoclast development.") AnnotationAssertion(rdfs:label "positive regulation of osteoclast development") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (regulation of vasculogenesis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of vasculogenesis.") AnnotationAssertion(rdfs:label "regulation of vasculogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of vasculogenesis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis.") AnnotationAssertion(rdfs:label "negative regulation of vasculogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of vasculogenesis) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of vasculogenesis.") AnnotationAssertion(rdfs:label "positive regulation of vasculogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of neuron migration) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of neuron migration.") AnnotationAssertion(rdfs:label "regulation of neuron migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) @@ -28844,28 +38242,33 @@ SubClassOf( ObjectAllValuesFrom( (negative regulation of neuron migration) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.") AnnotationAssertion(rdfs:label "negative regulation of neuron migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of neuron migration) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of neuron migration.") AnnotationAssertion(rdfs:label "positive regulation of neuron migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of apoptotic signaling pathway) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.") AnnotationAssertion(rdfs:label "regulation of apoptotic signaling pathway") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (negative regulation of apoptotic signaling pathway) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.") AnnotationAssertion(rdfs:label "negative regulation of apoptotic signaling pathway") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) # Class: (positive regulation of apoptotic signaling pathway) +AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.") AnnotationAssertion(rdfs:label "positive regulation of apoptotic signaling pathway") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) @@ -28875,457 +38278,741 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (negative regulation of chromosome organization) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization.") AnnotationAssertion(rdfs:label "negative regulation of chromosome organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (positive regulation of chromosome organization) +AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of chromosome organization.") AnnotationAssertion(rdfs:label "positive regulation of chromosome organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (root) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:30365038") +AnnotationAssertion( "PMID:32761142") AnnotationAssertion(rdfs:label "root") # Class: (Teleostomi) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Teleostomi") SubClassOf( ) # Class: (Euteleostomi) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Euteleostomi") SubClassOf( ) # Class: (Ecdysozoa) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Ecdysozoa") SubClassOf( ) # Class: (Zygnemophyceae) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Zygnemophyceae") SubClassOf( ) # Class: (Streptophytina) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Streptophytina") SubClassOf( ) # Class: (cellular organisms) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "cellular organisms") SubClassOf( ) # Class: (Archelosauria) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:22839753") +AnnotationAssertion( "PMID:25450099") AnnotationAssertion(rdfs:label "Archelosauria") SubClassOf( ) # Class: (Dipnotetrapodomorpha) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Dipnotetrapodomorpha") SubClassOf( ) # Class: (Eumycetozoa) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:11062127") +AnnotationAssertion( "PMID:9342353") AnnotationAssertion(rdfs:label "Eumycetozoa") SubClassOf( ) +# Class: (Boreoeutheria) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:11743200") +AnnotationAssertion( "PMID:11791233") +AnnotationAssertion(rdfs:label "Boreoeutheria") +SubClassOf( ) + # Class: (Acrogymnospermae) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Acrogymnospermae") SubClassOf( ) # Class: (Gnetidae) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Gnetidae") SubClassOf( ) # Class: (Saccharomycotina) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Saccharomycotina") SubClassOf( ) # Class: (Schizosaccharomycetes) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Schizosaccharomycetes") SubClassOf( ) # Class: (Actinopteri) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Actinopteri") SubClassOf( ) # Class: (Pancrustacea) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:10874751") +AnnotationAssertion( "PMID:11557979") AnnotationAssertion(rdfs:label "Pancrustacea") SubClassOf( ) # Class: (Mandibulata) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:11557979") +AnnotationAssertion( "PMID:9727836") AnnotationAssertion(rdfs:label "Mandibulata") SubClassOf( ) # Class: (Bacteria) +AnnotationAssertion( "GC_ID:11") +AnnotationAssertion( "PMID:10425795") +AnnotationAssertion( "PMID:10425796") +AnnotationAssertion( "PMID:10425797") +AnnotationAssertion( "PMID:10490293") +AnnotationAssertion( "PMID:10843050") +AnnotationAssertion( "PMID:10939651") +AnnotationAssertion( "PMID:10939673") +AnnotationAssertion( "PMID:10939677") +AnnotationAssertion( "PMID:11211268") +AnnotationAssertion( "PMID:11321083") +AnnotationAssertion( "PMID:11321113") +AnnotationAssertion( "PMID:11411719") +AnnotationAssertion( "PMID:11540071") +AnnotationAssertion( "PMID:11542017") +AnnotationAssertion( "PMID:11542087") +AnnotationAssertion( "PMID:11760965") +AnnotationAssertion( "PMID:12054223") +AnnotationAssertion( "PMID:2112744") +AnnotationAssertion( "PMID:270744") +AnnotationAssertion( "PMID:32628106") +AnnotationAssertion( "PMID:36748408") +AnnotationAssertion( "PMID:7520741") +AnnotationAssertion( "PMID:8123559") +AnnotationAssertion( "PMID:8186100") +AnnotationAssertion( "PMID:8590690") +AnnotationAssertion( "PMID:9103655") +AnnotationAssertion( "PMID:9336922") AnnotationAssertion(rdfs:label "Bacteria") SubClassOf( ) # Class: (Dictyosteliaceae) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:29367151") AnnotationAssertion(rdfs:label "Dictyosteliaceae") SubClassOf( ) # Class: (Dictyosteliales) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:29367151") AnnotationAssertion(rdfs:label "Dictyosteliales") SubClassOf( ) +# Class: (Homininae) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion(rdfs:label "Homininae") +SubClassOf( ) + # Class: (Archaea) +AnnotationAssertion( "GC_ID:11") +AnnotationAssertion( "PMID:10425795") +AnnotationAssertion( "PMID:10425796") +AnnotationAssertion( "PMID:10425797") +AnnotationAssertion( "PMID:10490293") +AnnotationAssertion( "PMID:10843050") +AnnotationAssertion( "PMID:10939651") +AnnotationAssertion( "PMID:10939673") +AnnotationAssertion( "PMID:10939677") +AnnotationAssertion( "PMID:11211268") +AnnotationAssertion( "PMID:11321083") +AnnotationAssertion( "PMID:11321113") +AnnotationAssertion( "PMID:11411719") +AnnotationAssertion( "PMID:11540071") +AnnotationAssertion( "PMID:11541975") +AnnotationAssertion( "PMID:11542064") +AnnotationAssertion( "PMID:11542149") +AnnotationAssertion( "PMID:11760965") +AnnotationAssertion( "PMID:12054223") +AnnotationAssertion( "PMID:2112744") +AnnotationAssertion( "PMID:25527841") +AnnotationAssertion( "PMID:270744") +AnnotationAssertion( "PMID:32628106") +AnnotationAssertion( "PMID:36748408") +AnnotationAssertion( "PMID:8123559") +AnnotationAssertion( "PMID:8590690") +AnnotationAssertion( "PMID:9103655") +AnnotationAssertion( "PMID:9336922") AnnotationAssertion(rdfs:label "Archaea") SubClassOf( ) # Class: (Evosea) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Evosea") SubClassOf( ) # Class: (Discoba) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Discoba") SubClassOf( ) # Class: (Zygnematophycidae) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Zygnematophycidae") SubClassOf( ) # Class: (Sar) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Sar") SubClassOf( ) # Class: (Eukaryota) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:23020233") +AnnotationAssertion( "PMID:30257078") AnnotationAssertion(rdfs:label "Eukaryota") SubClassOf( ) +# Class: (Euarchontoglires) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:11214319") +AnnotationAssertion( "PMID:12082125") +AnnotationAssertion( "PMID:12878460") +AnnotationAssertion( "PMID:15522813") +AnnotationAssertion(rdfs:label "Euarchontoglires") +SubClassOf( ) + +# Class: (Simiiformes) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion(rdfs:label "Simiiformes") +SubClassOf( ) + +# Class: (Hominoidea) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion(rdfs:label "Hominoidea") +SubClassOf( ) + # Class: (Zygnematales) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Zygnematales") SubClassOf( ) # Class: (Embryophyta) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Embryophyta") SubClassOf( ) # Class: (Teleostei) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Teleostei") SubClassOf( ) # Class: (Tetrapoda) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Tetrapoda") SubClassOf( ) # Class: (Amniota) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Amniota") SubClassOf( ) # Class: (Theria ) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Theria ") SubClassOf( ) # Class: (Sauria) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Sauria") SubClassOf( ) # Class: (Dictyostelia) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:11062127") +AnnotationAssertion( "PMID:29367151") +AnnotationAssertion( "PMID:9342353") AnnotationAssertion(rdfs:label "Dictyostelia") SubClassOf( ) # Class: (Viridiplantae) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:16248873") +AnnotationAssertion( "PMID:30257078") AnnotationAssertion(rdfs:label "Viridiplantae") SubClassOf( ) # Class: (Coniferophyta) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Coniferophyta") SubClassOf( ) # Class: (Opisthokonta) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Opisthokonta") SubClassOf( ) # Class: (Metazoa) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Metazoa") SubClassOf( ) # Class: (Bilateria) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Bilateria") SubClassOf( ) # Class: (Protostomia) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Protostomia") SubClassOf( ) # Class: (Deuterostomia) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Deuterostomia") SubClassOf( ) # Class: (Alveolata) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Alveolata") SubClassOf( ) # Class: (Euglenozoa) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Euglenozoa") SubClassOf( ) # Class: (Gnetopsida) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Gnetopsida") SubClassOf( ) # Class: (Gnetales) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Gnetales") SubClassOf( ) # Class: (Magnoliopsida) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:25249442") AnnotationAssertion(rdfs:label "Magnoliopsida") SubClassOf( ) # Class: (Schizosaccharomycetales) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Schizosaccharomycetales") SubClassOf( ) # Class: (Streptophyta) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Streptophyta") SubClassOf( ) +# Class: (Haplorrhini) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion(rdfs:label "Haplorrhini") +SubClassOf( ) + # Class: (Glaucocystophyceae) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Glaucocystophyceae") SubClassOf( ) # Class: (Mammalia) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Mammalia") SubClassOf( ) # Class: (Neopterygii) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Neopterygii") SubClassOf( ) # Class: (Dinosauria) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Dinosauria") SubClassOf( ) # Class: (Saurischia) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Saurischia") SubClassOf( ) # Class: (Theropoda) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Theropoda") SubClassOf( ) # Class: (Coelurosauria) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Coelurosauria") SubClassOf( ) # Class: (Dikarya) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:15689432") +AnnotationAssertion( "PMID:16151185") +AnnotationAssertion( "PMID:17010206") +AnnotationAssertion( "PMID:17051209") +AnnotationAssertion( "PMID:17572334") AnnotationAssertion(rdfs:label "Dikarya") SubClassOf( ) # Class: (Taphrinomycotina) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Taphrinomycotina") SubClassOf( ) # Class: (Fungi) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:11062127") +AnnotationAssertion( "PMID:12684019") AnnotationAssertion(rdfs:label "Fungi") SubClassOf( ) # Class: (Ascomycota) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:17572334") AnnotationAssertion(rdfs:label "Ascomycota") SubClassOf( ) # Class: (Saccharomycetes) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Saccharomycetes") SubClassOf( ) # Class: (Saccharomycetales) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Saccharomycetales") SubClassOf( ) # Class: (Saccharomycetaceae) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Saccharomycetaceae") SubClassOf( ) # Class: (Schizosaccharomycetaceae) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Schizosaccharomycetaceae") SubClassOf( ) # Class: (Schizosaccharomyces) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Schizosaccharomyces") SubClassOf( ) # Class: (Schizosaccharomyces pombe) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Schizosaccharomyces pombe") SubClassOf( ) # Class: (Saccharomyces) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Saccharomyces") SubClassOf( ) # Class: (Saccharomyces cerevisiae) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Saccharomyces cerevisiae") SubClassOf( ) # Class: (Insecta) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Insecta") SubClassOf( ) # Class: (Amoebozoa) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:23020233") +AnnotationAssertion( "PMID:30257078") AnnotationAssertion(rdfs:label "Amoebozoa") SubClassOf( ) # Class: (Dictyostelium) +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion( "PMID:29367151") AnnotationAssertion(rdfs:label "Dictyostelium") SubClassOf( ) # Class: (Tracheophyta) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Tracheophyta") SubClassOf( ) # Class: (Spermatophyta) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Spermatophyta") SubClassOf( ) # Class: (Eumetazoa) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Eumetazoa") SubClassOf( ) # Class: (Arthropoda) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Arthropoda") SubClassOf( ) # Class: (Hexapoda) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Hexapoda") SubClassOf( ) # Class: (saccharomyceta) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "saccharomyceta") SubClassOf( ) # Class: (Chordata) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Chordata") SubClassOf( ) # Class: (Vertebrata ) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Vertebrata ") SubClassOf( ) # Class: (Gnathostomata ) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Gnathostomata ") SubClassOf( ) # Class: (Euphyllophyta) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Euphyllophyta") SubClassOf( ) # Class: (Actinopterygii) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Actinopterygii") SubClassOf( ) # Class: (Sarcopterygii) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Sarcopterygii") SubClassOf( ) # Class: (Sauropsida) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Sauropsida") SubClassOf( ) # Class: (Archosauria) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Archosauria") SubClassOf( ) # Class: (Aves) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Aves") SubClassOf( ) # Class: (Panarthropoda) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Panarthropoda") SubClassOf( ) # Class: (Craniata ) +AnnotationAssertion( "GC_ID:1") AnnotationAssertion(rdfs:label "Craniata ") SubClassOf( ) +# Class: (Eutheria) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion(rdfs:label "Eutheria") +SubClassOf( ) + +# Class: (Primates) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion(rdfs:label "Primates") +SubClassOf( ) + +# Class: (Catarrhini) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion(rdfs:label "Catarrhini") +SubClassOf( ) + +# Class: (Hominidae) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion(rdfs:label "Hominidae") +SubClassOf( ) + +# Class: (Homo) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion(rdfs:label "Homo") +SubClassOf( ) + +# Class: (Homo sapiens) + +AnnotationAssertion( "GC_ID:1") +AnnotationAssertion(rdfs:label "Homo sapiens") +SubClassOf( ) + +# Class: (region) + +AnnotationAssertion(Annotation( "SO:ke") "A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids.") +AnnotationAssertion(rdfs:label "region") +SubClassOf( ) + +# Class: (sequence_feature) + +AnnotationAssertion(Annotation( "LAMHDI:mb") Annotation( "SO:ke") "Any extent of continuous biological sequence.") +AnnotationAssertion(rdfs:label "sequence_feature") + +# Class: (gene) + +AnnotationAssertion(Annotation( "SO:immuno_workshop") "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions.") +AnnotationAssertion(Annotation(rdfs:label "wiki") "http://en.wikipedia.org/wiki/Gene") +AnnotationAssertion(rdfs:comment "This term is mapped to MGED. Do not obsolete without consulting MGED ontology. A gene may be considered as a unit of inheritance.") +AnnotationAssertion(rdfs:label "gene") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (sequence_collection) +AnnotationAssertion(Annotation( "SO:ke") "A collection of discontinuous sequences.") AnnotationAssertion(rdfs:label "sequence_collection") +# Class: (biological_region) + +AnnotationAssertion(Annotation( "SO:cb") "A region defined by its disposition to be involved in a biological process.") +AnnotationAssertion(rdfs:label "biological_region") +SubClassOf( ) + +# Class: (gene_group) + +AnnotationAssertion(Annotation( "SO:ma") "A collection of related genes.") +AnnotationAssertion(rdfs:label "gene_group") +SubClassOf( ) + # Class: (processual entity) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "span:ProcessualEntity") "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity.") +AnnotationAssertion( "BFO:0000003") AnnotationAssertion(rdfs:label "processual entity") DisjointClasses( ) @@ -29338,8 +39025,43 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (islet of Langerhans) + +AnnotationAssertion(Annotation( "MA:0000127") Annotation( "MESH:A03.734.414") Annotation( "MP:0005215") "The clusters of hormone-producing cells that are scattered throughout the pancreas.") +AnnotationAssertion( "AAO:0010406") +AnnotationAssertion( "BTO:0000991") +AnnotationAssertion( "CALOHA:TS-0741") +AnnotationAssertion( "EFO:0000856") +AnnotationAssertion( "EMAPA:32927") +AnnotationAssertion( "EV:0100130") +AnnotationAssertion( "FMA:16016") +AnnotationAssertion( "GAID:324") +AnnotationAssertion( "MA:0000127") +AnnotationAssertion( "MAT:0000076") +AnnotationAssertion( "MESH:D007515") +AnnotationAssertion( "MIAA:0000076") +AnnotationAssertion( "NCIT:C12608") +AnnotationAssertion( "VHOG:0000646") +AnnotationAssertion( "Wikipedia:Islets_of_Langerhans") +AnnotationAssertion( "XAO:0000159") +AnnotationAssertion(rdfs:label "islet of Langerhans") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (submucosa) +AnnotationAssertion(Annotation( "Wikipedia:Submucosa") "A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted].") +AnnotationAssertion( "BTO:0002107") +AnnotationAssertion( "FMA:85391") +AnnotationAssertion( "FMA:85392") +AnnotationAssertion( "NCIT:C13167") +AnnotationAssertion( "SCTID:68439008") +AnnotationAssertion( "Wikipedia:Submucosa") AnnotationAssertion(rdfs:label "submucosa") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29348,13 +39070,58 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (peripheral nervous system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0007422") "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.") +AnnotationAssertion( "AAO:0000429") +AnnotationAssertion( "BAMS:PNS") +AnnotationAssertion( "BILA:0000081") +AnnotationAssertion( "BIRNLEX:1111") +AnnotationAssertion( "BTO:0001028") +AnnotationAssertion( "CALOHA:TS-0808") +AnnotationAssertion( "EFO:0000891") +AnnotationAssertion( "EHDAA2:0001445") +AnnotationAssertion( "EHDAA:2893") +AnnotationAssertion( "EMAPA:16665") +AnnotationAssertion( "EV:0100335") +AnnotationAssertion( "FMA:9903") +AnnotationAssertion( "GAID:715") +AnnotationAssertion( "MA:0000218") +AnnotationAssertion( "MAT:0000338") +AnnotationAssertion( "MESH:D017933") +AnnotationAssertion( "MIAA:0000338") +AnnotationAssertion( "NCIT:C12465") +AnnotationAssertion( "SCTID:362292005") +AnnotationAssertion( "TAO:0000142") +AnnotationAssertion( "VHOG:0000399") +AnnotationAssertion( "Wikipedia:Peripheral_nervous_system") +AnnotationAssertion( "XAO:0000178") +AnnotationAssertion( "ZFA:0000142") +AnnotationAssertion( "neuronames:3232") AnnotationAssertion(rdfs:label "peripheral nervous system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (sympathetic nervous system) +AnnotationAssertion(Annotation( "GO:0048485") "The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO].") +AnnotationAssertion( "AAO:0010487") +AnnotationAssertion( "BIRNLEX:2516") +AnnotationAssertion( "BTO:0001832") +AnnotationAssertion( "CALOHA:TS-2050") +AnnotationAssertion( "EFO:0000893") +AnnotationAssertion( "EHDAA2:0001971") +AnnotationAssertion( "EHDAA:3769") +AnnotationAssertion( "EMAPA:16985") +AnnotationAssertion( "FMA:9906") +AnnotationAssertion( "GAID:710") +AnnotationAssertion( "MA:0000225") +AnnotationAssertion( "MESH:D013564") +AnnotationAssertion( "MIAA:0000100") +AnnotationAssertion( "NCIT:C12795") +AnnotationAssertion( "SCTID:362484004") +AnnotationAssertion( "TAO:0001576") +AnnotationAssertion( "VHOG:0000384") +AnnotationAssertion( "Wikipedia:Sympathetic_nervous_system") +AnnotationAssertion( "ZFA:0001576") AnnotationAssertion(rdfs:label "sympathetic nervous system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29362,6 +39129,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (zone of skin) +AnnotationAssertion(Annotation( "Wikipedia:Skin") Annotation( "http://orcid.org/0000-0002-6601-2165") "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis.") +AnnotationAssertion( "EHDAA:6530") +AnnotationAssertion( "EV:0100152") +AnnotationAssertion( "FMA:86166") +AnnotationAssertion( "GAID:933") +AnnotationAssertion( "MA:0000151") +AnnotationAssertion( "MAT:0000284") +AnnotationAssertion( "MESH:D012867") +AnnotationAssertion( "MIAA:0000284") +AnnotationAssertion( "SCTID:20795001") +AnnotationAssertion( "VHOG:0000860") +AnnotationAssertion( "Wikipedia:Skin") AnnotationAssertion(rdfs:label "zone of skin") SubClassOf( ) SubClassOf( ) @@ -29371,14 +39150,78 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (non-material anatomical boundary) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0000010") "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures.") +AnnotationAssertion( "AEO:0000192") +AnnotationAssertion( "CARO:0000010") +AnnotationAssertion( "FMA:50705") +AnnotationAssertion(rdfs:comment "Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms.") AnnotationAssertion(rdfs:label "non-material anatomical boundary") SubClassOf( ) +# Class: (endocrine pancreas) + +AnnotationAssertion(Annotation( "GO:GO") Annotation( "http://orcid.org/0000-0002-6601-2165") "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin.") +AnnotationAssertion( "BTO:0000650") +AnnotationAssertion( "CALOHA:TS-1302") +AnnotationAssertion( "EFO:0002542") +AnnotationAssertion( "EMAPA:35305") +AnnotationAssertion( "EV:0100129") +AnnotationAssertion( "FMA:16018") +AnnotationAssertion( "MA:0001582") +AnnotationAssertion( "NCIT:C32509") +AnnotationAssertion( "SCTID:361339003") +AnnotationAssertion( "TAO:0001260") +AnnotationAssertion( "VHOG:0000049") +AnnotationAssertion( "Wikipedia:Islets_of_Langerhans") +AnnotationAssertion( "ZFA:0001260") +AnnotationAssertion(rdfs:label "endocrine pancreas") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (exocrine pancreas) + +AnnotationAssertion(Annotation( "GOC:GO") Annotation( "http://orcid.org/0000-0002-6601-2165") "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO].") +AnnotationAssertion( "AAO:0010407") +AnnotationAssertion( "BTO:0000434") +AnnotationAssertion( "CALOHA:TS-1241") +AnnotationAssertion( "EMAPA:35328") +AnnotationAssertion( "EV:0100093") +AnnotationAssertion( "FMA:16017") +AnnotationAssertion( "MA:0002415") +AnnotationAssertion( "NCIT:C32546") +AnnotationAssertion( "SCTID:248202004") +AnnotationAssertion( "TAO:0001249") +AnnotationAssertion( "VHOG:0000048") +AnnotationAssertion( "Wikipedia:Exocrine_component_of_pancreas") +AnnotationAssertion( "XAO:0000137") +AnnotationAssertion( "ZFA:0001249") +AnnotationAssertion(rdfs:label "exocrine pancreas") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (compound eye) +AnnotationAssertion(Annotation( "FB:gg") Annotation( "Wikipedia:Compound_eye") "A light sensing organ composed of ommatidia.") +AnnotationAssertion( "BTO:0001921") +AnnotationAssertion( "HAO:0000217") +AnnotationAssertion( "TGMA:0000024") +AnnotationAssertion( "Wikipedia:Compound_eye") AnnotationAssertion(rdfs:label "compound eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29387,6 +39230,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (camera-type eye) +AnnotationAssertion(Annotation( "GO:0043010") Annotation( "https://orcid.org/0000-0002-6601-2165") "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid.") +AnnotationAssertion( "AAO:0010340") +AnnotationAssertion( "BIRNLEX:1169") +AnnotationAssertion( "BTO:0004688") +AnnotationAssertion( "EHDAA2:0000484") +AnnotationAssertion( "EHDAA:936") +AnnotationAssertion( "EMAPA:16198") +AnnotationAssertion( "FMA:54448") +AnnotationAssertion( "MA:0000261") +AnnotationAssertion( "NCIT:C12401") +AnnotationAssertion( "SCTID:181143004") +AnnotationAssertion( "TAO:0000107") +AnnotationAssertion( "VHOG:0000275") +AnnotationAssertion( "XAO:0000179") +AnnotationAssertion( "ZFA:0000107") AnnotationAssertion(rdfs:label "camera-type eye") SubClassOf( ) SubClassOf( ) @@ -29401,6 +39259,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sense organ) +AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/issues/549") Annotation( "https://orcid.org/0000-0002-6601-2165") "An organ that is capable of transducing sensory stimulus to the nervous system.") +AnnotationAssertion( "AEO:0000094") +AnnotationAssertion( "BSA:0000121") +AnnotationAssertion( "BTO:0000202") +AnnotationAssertion( "CALOHA:TS-2043") +AnnotationAssertion( "EHDAA2:0001824") +AnnotationAssertion( "EHDAA:500") +AnnotationAssertion( "EMAPA:35955") +AnnotationAssertion( "GAID:63") +AnnotationAssertion( "HAO:0000930") +AnnotationAssertion( "MA:0000017") +AnnotationAssertion( "MESH:D012679") +AnnotationAssertion( "NCIT:C33224") +AnnotationAssertion( "SCTID:244485009") +AnnotationAssertion( "VHOG:0001407") +AnnotationAssertion( "WBbt:0006929") AnnotationAssertion(rdfs:label "sense organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29409,6 +39283,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tube) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported.") +AnnotationAssertion( "galen:Tube") AnnotationAssertion(rdfs:label "tube") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29417,12 +39293,34 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (appendage) +AnnotationAssertion(Annotation( "CARO:DOS") "Major subdivision of an organism that protrudes from the body[DOS, CARO].") +AnnotationAssertion( "AEO:0000193") +AnnotationAssertion( "BILA:0000018") +AnnotationAssertion( "BTO:0001492") +AnnotationAssertion( "CARO:0010003") +AnnotationAssertion( "EFO:0000799") +AnnotationAssertion( "EHDAA2:0003193") +AnnotationAssertion( "EV:0100155") +AnnotationAssertion( "HAO:0000144") +AnnotationAssertion( "MAT:0000023") +AnnotationAssertion( "MESH:D005121") +AnnotationAssertion( "MIAA:0000023") +AnnotationAssertion( "NCIT:C61460") +AnnotationAssertion( "VSAO:0000075") +AnnotationAssertion( "Wikipedia:Appendage") +AnnotationAssertion( "XAO:0000218") AnnotationAssertion(rdfs:label "appendage") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (lamina propria) +AnnotationAssertion(Annotation( "Wikipedia:Lamina_propria") "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions.") +AnnotationAssertion( "BTO:0002330") +AnnotationAssertion( "FMA:62517") +AnnotationAssertion( "NCIT:C32918") +AnnotationAssertion( "SCTID:298225002") +AnnotationAssertion( "Wikipedia:Lamina_propria") AnnotationAssertion(rdfs:label "lamina propria") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29431,6 +39329,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lamina propria of trachea) +AnnotationAssertion(Annotation( "OBOL:automatic") "A lamina propria that is part of a respiratory airway.") +AnnotationAssertion( "EMAPA:35877") +AnnotationAssertion( "FMA:265157") +AnnotationAssertion( "MA:0001858") +AnnotationAssertion( "NCIT:C49305") AnnotationAssertion(rdfs:label "lamina propria of trachea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29438,6 +39341,34 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (head) +AnnotationAssertion(Annotation( "GO:0060322") Annotation( "Wikipedia:Head") "The head is the anterior-most division of the body [GO].") +AnnotationAssertion( "AAO:0010335") +AnnotationAssertion( "AEO:0000106") +AnnotationAssertion( "BILA:0000115") +AnnotationAssertion( "BIRNLEX:1230") +AnnotationAssertion( "BTO:0000282") +AnnotationAssertion( "CALOHA:TS-0436") +AnnotationAssertion( "EFO:0000964") +AnnotationAssertion( "EHDAA2:0003106") +AnnotationAssertion( "EMAPA:31858") +AnnotationAssertion( "FMA:7154") +AnnotationAssertion( "GAID:61") +AnnotationAssertion( "HAO:0000397") +AnnotationAssertion( "MA:0000023") +AnnotationAssertion( "MAT:0000294") +AnnotationAssertion( "MESH:D006257") +AnnotationAssertion( "MIAA:0000294") +AnnotationAssertion( "NCIT:C12419") +AnnotationAssertion( "SCTID:302548004") +AnnotationAssertion( "SPD:0000016") +AnnotationAssertion( "TAO:0001114") +AnnotationAssertion( "TGMA:0000002") +AnnotationAssertion( "VHOG:0001644") +AnnotationAssertion( "WBbt:0005739") +AnnotationAssertion( "Wikipedia:Head") +AnnotationAssertion( "XAO:0003024") +AnnotationAssertion( "ZFA:0001114") +AnnotationAssertion( "galen:Head") AnnotationAssertion(rdfs:label "head") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29445,6 +39376,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (serous membrane) +AnnotationAssertion(Annotation( "Wikipedia:Serous_membrane") Annotation( "https://github.com/obophenotype/uberon/issues/86") "Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer.") +AnnotationAssertion( "FMA:9581") +AnnotationAssertion( "GAID:19") +AnnotationAssertion( "MESH:D012704") +AnnotationAssertion( "NCIT:C13169") +AnnotationAssertion( "SCTID:362878009") +AnnotationAssertion( "TAO:0005425") +AnnotationAssertion( "Wikipedia:Serous_membrane") +AnnotationAssertion( "ZFA:0005425") AnnotationAssertion(rdfs:label "serous membrane") SubClassOf( ) SubClassOf( ) @@ -29454,6 +39394,25 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tendon) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "VSAO:0000073") Annotation( "Wikipedia:Tendon") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Dense regular connective tissue that connects muscle to bone[VSAO].") +AnnotationAssertion( "AEO:0000091") +AnnotationAssertion( "BTO:0001356") +AnnotationAssertion( "CALOHA:TS-1021") +AnnotationAssertion( "EHDAA2:0003091") +AnnotationAssertion( "EMAPA:35854") +AnnotationAssertion( "EV:0100149") +AnnotationAssertion( "FMA:9721") +AnnotationAssertion( "GAID:276") +AnnotationAssertion( "MA:0000115") +AnnotationAssertion( "MESH:D013710") +AnnotationAssertion( "NCIT:C13045") +AnnotationAssertion( "SCTID:256667004") +AnnotationAssertion( "VHOG:0001286") +AnnotationAssertion( "VSAO:0000073") +AnnotationAssertion( "Wikipedia:Tendon") +AnnotationAssertion( "XAO:0000173") +AnnotationAssertion( "ZFA:0005647") +AnnotationAssertion( "galen:Tendon") AnnotationAssertion(rdfs:label "tendon") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29464,7 +39423,36 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ganglion) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Ganglion") Annotation( "https://github.com/obophenotype/uberon/issues/300") "A biological tissue mass, most commonly a mass of nerve cell bodies.") +AnnotationAssertion( "AAO:0010426") +AnnotationAssertion( "AEO:0000135") +AnnotationAssertion( "BAMS:G") +AnnotationAssertion( "BTO:0000497") +AnnotationAssertion( "CALOHA:TS-0397") +AnnotationAssertion( "EFO:0000899") +AnnotationAssertion( "EHDAA2:0003135") +AnnotationAssertion( "EHDAA:2897") +AnnotationAssertion( "EHDAA:4662") +AnnotationAssertion( "EHDAA:5621") +AnnotationAssertion( "EHDAA:918") +AnnotationAssertion( "EMAPA:32846") +AnnotationAssertion( "EV:0100372") +AnnotationAssertion( "FMA:5884") +AnnotationAssertion( "MA:0002406") +AnnotationAssertion( "MAT:0000207") +AnnotationAssertion( "MAT:0000343") +AnnotationAssertion( "MESH:D005724") +AnnotationAssertion( "MIAA:0000207") +AnnotationAssertion( "MIAA:0000343") +AnnotationAssertion( "NCIT:C12719") +AnnotationAssertion( "NLXANAT:100302") +AnnotationAssertion( "TAO:0000190") +AnnotationAssertion( "TGMA:0001016") +AnnotationAssertion( "VHOG:0000156") +AnnotationAssertion( "WBbt:0005189") +AnnotationAssertion( "Wikipedia:Ganglion") +AnnotationAssertion( "XAO:0000209") +AnnotationAssertion( "ZFA:0000190") AnnotationAssertion(rdfs:label "ganglion") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29473,26 +39461,70 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (simple eye) +AnnotationAssertion(Annotation( "Wikipedia:Eye#Simple_eyes") "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity.") +AnnotationAssertion( "TGMA:0000729") +AnnotationAssertion( "Wikipedia:Eye#Simple_eyes") AnnotationAssertion(rdfs:label "simple eye") SubClassOf( ) # Class: (vessel) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A tubular structure that contains, conveys body fluid, such as blood or lymph.") AnnotationAssertion(rdfs:label "vessel") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (duct) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "http://www.siumed.edu/~dking2/intro/glands.htm#ducts") "A tubular structure that transports secreted or excreted substances.") +AnnotationAssertion( "AAO:0011123") +AnnotationAssertion( "FMA:30320") +AnnotationAssertion( "NCIT:C12948") +AnnotationAssertion( "SCTID:91726008") +AnnotationAssertion( "TAO:0005171") +AnnotationAssertion( "Wikipedia:Duct_(anatomy)") +AnnotationAssertion( "XAO:0004000") +AnnotationAssertion( "ZFA:0005171") +AnnotationAssertion( "galen:Duct") AnnotationAssertion(rdfs:label "duct") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (large intestine) + +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Large_intestine_(anatomy)") "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong].") +AnnotationAssertion( "AAO:0010396") +AnnotationAssertion( "BTO:0000706") +AnnotationAssertion( "CALOHA:TS-1306") +AnnotationAssertion( "EFO:0000840") +AnnotationAssertion( "EMAPA:19252") +AnnotationAssertion( "EV:0100077") +AnnotationAssertion( "FMA:7201") +AnnotationAssertion( "GAID:306") +AnnotationAssertion( "MA:0000333") +AnnotationAssertion( "MESH:D007420") +AnnotationAssertion( "MIAA:0000046") +AnnotationAssertion( "NCIT:C12379") +AnnotationAssertion( "SCTID:181254001") +AnnotationAssertion( "VHOG:0000054") +AnnotationAssertion( "Wikipedia:Large_intestine_(anatomy)") +AnnotationAssertion( "XAO:0000131") +AnnotationAssertion( "galen:LargeIntestine") +AnnotationAssertion(rdfs:label "large intestine") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (anatomical wall) +AnnotationAssertion(Annotation( "FMA:82482") "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers.") +AnnotationAssertion( "FMA:82482") +AnnotationAssertion( "galen:Wall") AnnotationAssertion(rdfs:label "anatomical wall") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29500,18 +39532,44 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anatomical structure) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0000003") "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.") +AnnotationAssertion( "AAO:0010825") +AnnotationAssertion( "AEO:0000003") +AnnotationAssertion( "BILA:0000003") +AnnotationAssertion( "CARO:0000003") +AnnotationAssertion( "EHDAA2:0003003") +AnnotationAssertion( "EMAPA:0") +AnnotationAssertion( "FMA:305751") +AnnotationAssertion( "FMA:67135") +AnnotationAssertion( "GAID:781") +AnnotationAssertion( "HAO:0000003") +AnnotationAssertion( "MA:0003000") +AnnotationAssertion( "MESH:D000825") +AnnotationAssertion( "SCTID:362889002") +AnnotationAssertion( "TAO:0000037") +AnnotationAssertion( "TGMA:0001823") +AnnotationAssertion( "VHOG:0001759") +AnnotationAssertion( "XAO:0003000") +AnnotationAssertion( "ZFA:0000037") +AnnotationAssertion( "http://dbpedia.org/ontology/AnatomicalStructure") AnnotationAssertion(rdfs:label "anatomical structure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (organ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Organ_(anatomy)") "Anatomical structure that performs a specific function or group of functions [WP].") +AnnotationAssertion( "BIRNLEX:4") +AnnotationAssertion( "CARO:0020004") +AnnotationAssertion( "EFO:0000634") +AnnotationAssertion( "EMAPA:35949") +AnnotationAssertion( "ENVO:01000162") +AnnotationAssertion( "FMA:67498") +AnnotationAssertion( "MA:0003001") +AnnotationAssertion( "NCIT:C13018") +AnnotationAssertion( "SCTID:272625005") +AnnotationAssertion( "WBbt:0003760") +AnnotationAssertion( "Wikipedia:Organ_(anatomy)") AnnotationAssertion(rdfs:label "organ") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29521,21 +39579,34 @@ DisjointClasses( (organ subunit) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity.") +AnnotationAssertion( "FMA:86140") AnnotationAssertion(rdfs:label "organ subunit") SubClassOf( ) # Class: (organ part) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A multicellular structure that is a part of an organ.") +AnnotationAssertion( "AAO:0011124") +AnnotationAssertion( "BIRNLEX:16") +AnnotationAssertion( "EFO:0000635") +AnnotationAssertion( "FMA:82472") +AnnotationAssertion( "SCTID:113343008") +AnnotationAssertion( "SCTID:91717005") AnnotationAssertion(rdfs:label "organ part") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (respiratory tract) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts.") +AnnotationAssertion( "EHDAA2:0001606") +AnnotationAssertion( "EHDAA:1568") +AnnotationAssertion( "EHDAA:2219") +AnnotationAssertion( "EMAPA:16737") +AnnotationAssertion( "FMA:265130") +AnnotationAssertion( "SCTID:361110005") +AnnotationAssertion( "VHOG:0000393") AnnotationAssertion(rdfs:label "respiratory tract") SubClassOf( ) SubClassOf( ) @@ -29544,6 +39615,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (fully formed stage) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.") +AnnotationAssertion( "BTO:0001043") +AnnotationAssertion( "BilaDO:0000004") +AnnotationAssertion( "EFO:0001272") +AnnotationAssertion( "FBdv:00005369") +AnnotationAssertion( "WBls:0000041") +AnnotationAssertion( "XtroDO:0000084") AnnotationAssertion(rdfs:label "fully formed stage") SubClassOf( ) SubClassOf( ) @@ -29553,6 +39631,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (embryo stage) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A life cycle stage that starts with fertilization and ends with the fully formed embryo.") +AnnotationAssertion( "BilaDO:0000002") +AnnotationAssertion( "EV:0300001") +AnnotationAssertion( "FBdv:00005289") +AnnotationAssertion( "FMA:72652") +AnnotationAssertion( "HsapDv:0000002") +AnnotationAssertion( "MmusDv:0000002") +AnnotationAssertion( "OGES:000000") +AnnotationAssertion( "OGES:000022") +AnnotationAssertion( "SCTID:296280003") +AnnotationAssertion( "WBls:0000003") +AnnotationAssertion( "WBls:0000092") +AnnotationAssertion( "WBls:0000102") +AnnotationAssertion( "XAO:1000012") AnnotationAssertion(rdfs:label "embryo stage") SubClassOf( ) SubClassOf( ) @@ -29563,9 +39655,9 @@ DisjointClasses( (death stage) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "XAO:0000437") "End of the life of an organism.") +AnnotationAssertion( "XAO:0000437") +AnnotationAssertion( "XtroDO:0000085") AnnotationAssertion(rdfs:label "death stage") SubClassOf( ) SubClassOf( ) @@ -29573,6 +39665,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (proximo-distal subdivision of respiratory tract) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An section of a respiratory tract.") +AnnotationAssertion( "FMA:45660") +AnnotationAssertion( "MA:0000434") AnnotationAssertion(rdfs:label "proximo-distal subdivision of respiratory tract") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29581,6 +39676,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (regional part of nervous system) +AnnotationAssertion(Annotation( "BIRNLEX:1157") "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS.") +AnnotationAssertion( "BIRNLEX:1157") +AnnotationAssertion( "NCIT:C13040") +AnnotationAssertion( "SCTID:25087005") AnnotationAssertion(rdfs:label "regional part of nervous system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29588,6 +39687,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (subdivision of skeletal system) +AnnotationAssertion(Annotation( "UBERONREF:0000003") Annotation( "https://orcid.org/0000-0002-6601-2165") "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.") +AnnotationAssertion( "FMA:85544") +AnnotationAssertion( "NCIT:C34076") +AnnotationAssertion( "SCTID:118966000") +AnnotationAssertion( "galen:ComplexSkeletalStructure") AnnotationAssertion(rdfs:label "subdivision of skeletal system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29596,6 +39700,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (external ectoderm) +AnnotationAssertion(Annotation( "MGI:anna") Annotation( "MP:0012532") "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm.") +AnnotationAssertion( "EHDAA2:0001968") +AnnotationAssertion( "EHDAA:1494") +AnnotationAssertion( "EHDAA:350") +AnnotationAssertion( "EHDAA:4784") +AnnotationAssertion( "EHDAA:4790") +AnnotationAssertion( "EHDAA:4796") +AnnotationAssertion( "EHDAA:7860") +AnnotationAssertion( "EMAPA:16096") +AnnotationAssertion( "FMA:87656") +AnnotationAssertion( "NCIT:C34309") +AnnotationAssertion( "Wikipedia:External_ectoderm") AnnotationAssertion(rdfs:label "external ectoderm") SubClassOf( ) SubClassOf( ) @@ -29603,6 +39719,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mixed endoderm/mesoderm-derived structure) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An anatomical structure that develops from the endoderm and the mesoderm.") AnnotationAssertion(rdfs:label "mixed endoderm/mesoderm-derived structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29610,6 +39727,7 @@ SubClassOf( (mixed ectoderm/mesoderm/endoderm-derived structure) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An anatomical structure that develops from the ectoderm, mesoderm and endoderm.") AnnotationAssertion(rdfs:label "mixed ectoderm/mesoderm/endoderm-derived structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29617,6 +39735,15 @@ SubClassOf( (morula) +AnnotationAssertion(Annotation( "MP:0012130") "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum.") +AnnotationAssertion( "BTO:0001508") +AnnotationAssertion( "EHDAA2:0000005") +AnnotationAssertion( "FMA:292334") +AnnotationAssertion( "GAID:1295") +AnnotationAssertion( "MESH:D009028") +AnnotationAssertion( "NCIT:C34212") +AnnotationAssertion( "SCTID:361474003") +AnnotationAssertion( "Wikipedia:Morula") AnnotationAssertion(rdfs:label "morula") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29627,7 +39754,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (zona pellucida) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Zona_pellucida") "A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes.") +AnnotationAssertion( "BTO:0003135") +AnnotationAssertion( "EHDAA2:0002220") +AnnotationAssertion( "EHDAA:31") +AnnotationAssertion( "EHDAA:62") +AnnotationAssertion( "EMAPA:16035") +AnnotationAssertion( "FMA:18674") +AnnotationAssertion( "GAID:410") +AnnotationAssertion( "MA:0001715") +AnnotationAssertion( "MESH:D015044") +AnnotationAssertion( "NCIT:C33896") +AnnotationAssertion( "TAO:0001111") +AnnotationAssertion( "Wikipedia:Zona_pellucida") +AnnotationAssertion( "ZFA:0001111") AnnotationAssertion(rdfs:label "zona pellucida") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29636,6 +39776,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (inner cell mass) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MGI:pvb") "A mass of cells that develop into the body of the embryo and some extraembryonic tissues.") +AnnotationAssertion( "EFO:0000547") +AnnotationAssertion( "EHDAA2:0000830") +AnnotationAssertion( "EHDAA:40") +AnnotationAssertion( "EMAPA:16041") +AnnotationAssertion( "FMA:86557") +AnnotationAssertion( "NCIT:C13740") +AnnotationAssertion( "SCTID:361456007") +AnnotationAssertion( "VHOG:0000742") +AnnotationAssertion( "Wikipedia:Inner_cell_mass") AnnotationAssertion(rdfs:label "inner cell mass") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29643,6 +39793,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trophoblast) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0005031") "The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta.") +AnnotationAssertion( "BTO:0001079") +AnnotationAssertion( "CALOHA:TS-1070") +AnnotationAssertion( "EV:0100120") +AnnotationAssertion( "FMA:83029") +AnnotationAssertion( "GAID:1152") +AnnotationAssertion( "MESH:D014327") +AnnotationAssertion( "NCIT:C93292") +AnnotationAssertion( "SCTID:362839005") +AnnotationAssertion( "Wikipedia:Trophoblast") +AnnotationAssertion(rdfs:comment "Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast]") AnnotationAssertion(rdfs:label "trophoblast") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29651,12 +39812,24 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bilaminar disc) +AnnotationAssertion(Annotation( "MP:0003886") "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc.") +AnnotationAssertion( "FMA:293863") +AnnotationAssertion( "NCIT:C34112") +AnnotationAssertion( "Wikipedia:Bilaminar_disc") AnnotationAssertion(rdfs:label "bilaminar disc") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (post-embryonic stage) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "Stage succeeding embryo, including mature structure.") +AnnotationAssertion( "BilaDO:0000003") +AnnotationAssertion( "OGES:000010") +AnnotationAssertion( "OGES:000014") +AnnotationAssertion( "OGES:000024") +AnnotationAssertion( "WBls:0000022") +AnnotationAssertion( "WBls:0000093") +AnnotationAssertion( "WBls:0000103") AnnotationAssertion(rdfs:label "post-embryonic stage") SubClassOf( ) SubClassOf( ) @@ -29665,12 +39838,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (membrane organ) +AnnotationAssertion(Annotation( "FMA:7145") "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA].") +AnnotationAssertion( "FMA:7145") AnnotationAssertion(rdfs:label "membrane organ") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cardiac neural crest) +AnnotationAssertion(Annotation( "Wikipedia:Cardiac_neural_crest") "Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia].") +AnnotationAssertion( "TAO:0002173") +AnnotationAssertion( "Wikipedia:Cardiac_neural_crest") +AnnotationAssertion( "XAO:0004190") +AnnotationAssertion( "ZFA:0001648") AnnotationAssertion(rdfs:label "cardiac neural crest") SubClassOf( ) SubClassOf( ) @@ -29679,6 +39859,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lobe of lung) +AnnotationAssertion(Annotation( "GOC:GO") "A lung lobe is one of the rounded projections that compose the lung[GO].") +AnnotationAssertion( "EMAPA:36281") +AnnotationAssertion( "FMA:7311") +AnnotationAssertion( "MA:0003098") +AnnotationAssertion( "NCIT:C34021") +AnnotationAssertion( "SCTID:245524004") +AnnotationAssertion( "galen:LobeOfLung") AnnotationAssertion(rdfs:label "lobe of lung") SubClassOf( ) SubClassOf( ) @@ -29687,6 +39874,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung vasculature) +AnnotationAssertion(Annotation( "GOC:GO") "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO].") +AnnotationAssertion( "FMA:73750") AnnotationAssertion(rdfs:label "lung vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29695,9 +39884,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (life cycle) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism.") +AnnotationAssertion( "FBdv:00000000") +AnnotationAssertion( "HsapDv:0000001") +AnnotationAssertion( "MmusDv:0000001") +AnnotationAssertion( "OGES:000011") +AnnotationAssertion( "ncithesaurus:Life") AnnotationAssertion(rdfs:label "life cycle") SubClassOf( ) SubClassOf( ) @@ -29706,15 +39898,39 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (life cycle stage) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A spatiotemporal region encompassing some part of the life cycle of an organism.") +AnnotationAssertion( "BILS:0000105") +AnnotationAssertion( "EFO:0000399") +AnnotationAssertion( "FBdv:00007012") +AnnotationAssertion( "FMA:24120") +AnnotationAssertion( "HsapDv:0000000") +AnnotationAssertion( "MESH:D008018") +AnnotationAssertion( "MmusDv:0000000") +AnnotationAssertion( "OlatDv:0000010") +AnnotationAssertion( "PdumDv:0000090") +AnnotationAssertion( "WBls:0000002") +AnnotationAssertion( "XAO:1000000") +AnnotationAssertion( "ZFS:0000000") +AnnotationAssertion( "ZFS:0100000") +AnnotationAssertion( "ncithesaurus:Developmental_Stage") AnnotationAssertion(rdfs:label "life cycle stage") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (zygote stage) +AnnotationAssertion(Annotation( "Wikipedia:Zygote") "A stage at which the organism is a single cell produced by means of sexual reproduction.") +AnnotationAssertion( "BILS:0000106") +AnnotationAssertion( "BilaDO:0000005") +AnnotationAssertion( "EFO:0001322") +AnnotationAssertion( "EHDAA:27") +AnnotationAssertion( "FBdv:00005288") +AnnotationAssertion( "NCIT:C12601") +AnnotationAssertion( "PdumDv:0000100") +AnnotationAssertion( "VHOG:0000745") +AnnotationAssertion( "Wikipedia:Zygote") +AnnotationAssertion( "XAO:1000001") +AnnotationAssertion( "ZFS:0000001") AnnotationAssertion(rdfs:label "zygote stage") SubClassOf( ) SubClassOf( ) @@ -29723,6 +39939,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cleavage stage) +AnnotationAssertion(Annotation( "GO:0040016") Annotation( "Wikipedia:Cleavage_(embryo)") "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.") +AnnotationAssertion( "BILS:0000107") +AnnotationAssertion( "BilaDO:0000006") +AnnotationAssertion( "EFO:0001290") +AnnotationAssertion( "FBdv:00000054") +AnnotationAssertion( "MESH:D002970") +AnnotationAssertion( "MmusDv:0000004") +AnnotationAssertion( "OGES:000015") +AnnotationAssertion( "OGES:000020") +AnnotationAssertion( "PdumDv:0000200") +AnnotationAssertion( "Wikipedia:Cleavage_(embryo)") +AnnotationAssertion( "XAO:1000004") +AnnotationAssertion( "ZFS:0000046") AnnotationAssertion(rdfs:label "cleavage stage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29733,6 +39962,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (blastula stage) +AnnotationAssertion(Annotation( "Wikipedia:Blastula") "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.") +AnnotationAssertion( "BILS:0000108") +AnnotationAssertion( "BilaDO:0000007") +AnnotationAssertion( "EFO:0001282") +AnnotationAssertion( "HsapDv:0000006") +AnnotationAssertion( "MmusDv:0000007") +AnnotationAssertion( "OGES:000003") +AnnotationAssertion( "OGES:000016") +AnnotationAssertion( "OGES:000021") +AnnotationAssertion( "WBls:0000005") +AnnotationAssertion( "Wikipedia:Blastula") +AnnotationAssertion( "XAO:1000003") +AnnotationAssertion( "ZFS:0000045") AnnotationAssertion(rdfs:label "blastula stage") SubClassOf( ) SubClassOf( ) @@ -29741,6 +39983,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gastrula stage) +AnnotationAssertion(Annotation( "GO:0007369") "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.") +AnnotationAssertion( "BILS:0000109") +AnnotationAssertion( "BilaDO:0000008") +AnnotationAssertion( "EFO:0001296") +AnnotationAssertion( "FBdv:00005317") +AnnotationAssertion( "HsapDv:0000010") +AnnotationAssertion( "MmusDv:0000013") +AnnotationAssertion( "OGES:000004") +AnnotationAssertion( "OGES:000019") +AnnotationAssertion( "WBls:0000010") +AnnotationAssertion( "XAO:1000005") +AnnotationAssertion( "ZFS:0000047") AnnotationAssertion(rdfs:label "gastrula stage") SubClassOf( ) SubClassOf( ) @@ -29751,6 +40005,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neurula stage) +AnnotationAssertion(Annotation( "GO:0001841") "Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.") +AnnotationAssertion( "BILS:0000110") +AnnotationAssertion( "BilaDO:0000009") +AnnotationAssertion( "HsapDv:0000012") +AnnotationAssertion( "MmusDv:0000017") +AnnotationAssertion( "XAO:1000006") AnnotationAssertion(rdfs:label "neurula stage") SubClassOf( ) SubClassOf( ) @@ -29761,6 +40021,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (organogenesis stage) +AnnotationAssertion(Annotation( "Wikipedia:Organogenesis") "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.") +AnnotationAssertion( "BILS:0000111") +AnnotationAssertion( "BilaDO:0000010") +AnnotationAssertion( "HsapDv:0000015") +AnnotationAssertion( "MmusDv:0000018") +AnnotationAssertion( "OGES:000005") +AnnotationAssertion( "OGES:000032") +AnnotationAssertion( "Wikipedia:Organogenesis") AnnotationAssertion(rdfs:label "organogenesis stage") SubClassOf( ) SubClassOf( ) @@ -29770,7 +40038,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung connective tissue) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MGI:anna") Annotation( "MP:0002276") Annotation( "PMID:14635660") "The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin.") +AnnotationAssertion( "EMAPA:35521") +AnnotationAssertion( "FMA:27533") +AnnotationAssertion( "MA:0001782") +AnnotationAssertion( "SCTID:201609008") AnnotationAssertion(rdfs:label "lung connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29782,6 +40054,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung epithelium) +AnnotationAssertion(Annotation( "MP:0006382") "The epithelial layer of the lung.") +AnnotationAssertion( "BTO:0001653") +AnnotationAssertion( "EMAPA:32860") +AnnotationAssertion( "MA:0001783") AnnotationAssertion(rdfs:label "lung epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29791,6 +40067,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory tube) +AnnotationAssertion(Annotation( "GO:0030323") Annotation( "http://orcid.org/0000-0002-6601-2165") "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea.") +AnnotationAssertion( "FMA:12224") AnnotationAssertion(rdfs:label "respiratory tube") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29800,6 +40078,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung bud) +AnnotationAssertion(Annotation( "GO:0060431") Annotation( "Wikipedia:Respiratory_bud") "Structure derived from foregut that becomes a lung[GO].") +AnnotationAssertion( "BTO:0001643") +AnnotationAssertion( "EHDAA2:0004089") +AnnotationAssertion( "NCIT:C34260") +AnnotationAssertion( "NCIT:C34282") +AnnotationAssertion( "SCTID:361427007") +AnnotationAssertion( "Wikipedia:Respiratory_bud") AnnotationAssertion(rdfs:label "lung bud") SubClassOf( ) SubClassOf( ) @@ -29809,6 +40094,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neuron projection bundle) +AnnotationAssertion(Annotation( "CARO:0001001") Annotation( "FBC:DOS") Annotation( "FBbt:00005099") "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.") +AnnotationAssertion( "CARO:0001001") +AnnotationAssertion( "NLX:147821") AnnotationAssertion(rdfs:label "neuron projection bundle") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29816,6 +40104,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural nucleus) +AnnotationAssertion(Annotation( "NLX:28443") "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO).") +AnnotationAssertion( "AEO:0000136") +AnnotationAssertion( "FMA:83686") +AnnotationAssertion( "NCIT:C13197") +AnnotationAssertion( "NLX:28443") +AnnotationAssertion( "Wikipedia:Nucleus_(neuroanatomy)") AnnotationAssertion(rdfs:label "neural nucleus") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29823,6 +40117,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranial nerve nucleus) +AnnotationAssertion(Annotation( "NLX:28532") "Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves.") +AnnotationAssertion( "FMA:54501") +AnnotationAssertion( "NLX:28532") +AnnotationAssertion( "SCTID:280160003") +AnnotationAssertion( "Wikipedia:Cranial_nerve_nucleus") AnnotationAssertion(rdfs:label "cranial nerve nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29843,17 +40142,139 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (membranous layer) +AnnotationAssertion( "FMA:30322") +AnnotationAssertion( "FMA:82500") +AnnotationAssertion( "MESH:D008566") +AnnotationAssertion( "NCIT:C12749") AnnotationAssertion(rdfs:label "membranous layer") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (anal canal) + +AnnotationAssertion(Annotation( "Wikipedia:Anal_canal") "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus.") +AnnotationAssertion( "BTO:0001978") +AnnotationAssertion( "CALOHA:TS-2160") +AnnotationAssertion( "EMAPA:18256") +AnnotationAssertion( "FMA:15703") +AnnotationAssertion( "MA:0000330") +AnnotationAssertion( "NCIT:C12375") +AnnotationAssertion( "SCTID:245438008") +AnnotationAssertion( "Wikipedia:Anal_canal") +AnnotationAssertion( "galen:AnalCanal") +AnnotationAssertion(rdfs:label "anal canal") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (intestine) + +AnnotationAssertion(Annotation( "GOC:GO") Annotation( "Wikipedia:Intestine") "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine.") +AnnotationAssertion( "AAO:0000246") +AnnotationAssertion( "ANISEED:1235303") +AnnotationAssertion( "BSA:0000093") +AnnotationAssertion( "BTO:0000648") +AnnotationAssertion( "CALOHA:TS-0490") +AnnotationAssertion( "EFO:0000834") +AnnotationAssertion( "EMAPA:32874") +AnnotationAssertion( "EV:0100071") +AnnotationAssertion( "FMA:7199") +AnnotationAssertion( "GAID:295") +AnnotationAssertion( "MA:0000328") +AnnotationAssertion( "MA:0001524") +AnnotationAssertion( "MESH:D007422") +AnnotationAssertion( "MIAA:0000043") +AnnotationAssertion( "NCIT:C12736") +AnnotationAssertion( "SCTID:256876008") +AnnotationAssertion( "TAO:0001338") +AnnotationAssertion( "VHOG:0000056") +AnnotationAssertion( "WBbt:0005772") +AnnotationAssertion( "Wikipedia:Intestine") +AnnotationAssertion( "XAO:0000129") +AnnotationAssertion( "ZFA:0001338") +AnnotationAssertion( "galen:Intestine") +AnnotationAssertion(rdfs:label "intestine") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (orifice) +AnnotationAssertion(Annotation( "FMA:3724") "Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified].") +AnnotationAssertion( "FMA:3724") +AnnotationAssertion( "SCTID:91837002") AnnotationAssertion(rdfs:label "orifice") SubClassOf( ) +# Class: (cloaca) + +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Cloaca") "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures.") +AnnotationAssertion( "AAO:0000095") +AnnotationAssertion( "GAID:1206") +AnnotationAssertion( "MESH:D002988") +AnnotationAssertion( "NCIT:C34127") +AnnotationAssertion( "SCTID:362857006") +AnnotationAssertion( "SCTID:370631000") +AnnotationAssertion( "VHOG:0001186") +AnnotationAssertion( "Wikipedia:Cloaca") +AnnotationAssertion( "XAO:0000244") +AnnotationAssertion( "ZFA:0005781") +AnnotationAssertion(rdfs:label "cloaca") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (embryonic cloaca) + +AnnotationAssertion(Annotation( "MP:0010115") Annotation( "Wikipedia:Cloaca_(embryology)") "Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP].") +AnnotationAssertion( "EHDAA2:0000256") +AnnotationAssertion( "EHDAA:4895") +AnnotationAssertion( "EMAPA:27573") +AnnotationAssertion( "Wikipedia:Cloaca_(embryology)") +AnnotationAssertion(rdfs:label "embryonic cloaca") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mouth) +AnnotationAssertion(Annotation( "Wikipedia:Mouth") Annotation( "https://github.com/obophenotype/uberon/wiki/The-digestive-tract") "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks).") +AnnotationAssertion( "AAO:0010355") +AnnotationAssertion( "BTO:0001090") +AnnotationAssertion( "BTO:0004698") +AnnotationAssertion( "CALOHA:TS-1315") +AnnotationAssertion( "EFO:0000825") +AnnotationAssertion( "EHDAA2:0001326") +AnnotationAssertion( "EHDAA:542") +AnnotationAssertion( "EMAPA:16262") +AnnotationAssertion( "FMA:49184") +AnnotationAssertion( "GAID:75") +AnnotationAssertion( "MA:0000341") +AnnotationAssertion( "MA:0002474") +AnnotationAssertion( "MAT:0000038") +AnnotationAssertion( "MESH:D009055") +AnnotationAssertion( "MIAA:0000038") +AnnotationAssertion( "SCTID:21082005") +AnnotationAssertion( "TADS:0000040") +AnnotationAssertion( "TAO:0000547") +AnnotationAssertion( "TAO:0000590") +AnnotationAssertion( "TGMA:0000131") +AnnotationAssertion( "VHOG:0000280") +AnnotationAssertion( "VHOG:0000812") +AnnotationAssertion( "Wikipedia:Mouth") +AnnotationAssertion( "XAO:0003029") +AnnotationAssertion( "ZFA:0000547") +AnnotationAssertion( "ZFA:0000590") +AnnotationAssertion( "galen:Mouth") +AnnotationAssertion( "http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg") AnnotationAssertion(rdfs:label "mouth") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29863,12 +40284,35 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (oral opening) +AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/wiki/The-digestive-tract") "The orifice that connects the mouth to the exterior of the body.") +AnnotationAssertion( "FMA:59806") AnnotationAssertion(rdfs:label "oral opening") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (oral cavity) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "https://github.com/obophenotype/uberon/wiki/The-digestive-tract") Annotation( "https://orcid.org/0000-0002-6601-2165") "Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present).") +AnnotationAssertion( "AAO:0000053") +AnnotationAssertion( "AAO:0000960") +AnnotationAssertion( "BSA:0000107") +AnnotationAssertion( "CALOHA:TS-1315") +AnnotationAssertion( "EFO:0001975") +AnnotationAssertion( "EHDAA2:0001324") +AnnotationAssertion( "EHDAA:6970") +AnnotationAssertion( "EMAPA:17411") +AnnotationAssertion( "EMAPA:18399") +AnnotationAssertion( "EV:0100057") +AnnotationAssertion( "FMA:20292") +AnnotationAssertion( "HAO:0000669") +AnnotationAssertion( "NCIT:C12421") +AnnotationAssertion( "SCTID:181220002") +AnnotationAssertion( "TAO:0001027") +AnnotationAssertion( "TGMA:0000102") +AnnotationAssertion( "VHOG:0000188") +AnnotationAssertion( "WBbt:0005255") +AnnotationAssertion( "XAO:0000126") +AnnotationAssertion( "ZFA:0001027") AnnotationAssertion(rdfs:label "oral cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29876,9 +40320,20 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (proximal-distal subdivision of colon) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A section dividing a colon along a proximal-distal axis.") +AnnotationAssertion( "FMA:222905") +AnnotationAssertion(rdfs:label "proximal-distal subdivision of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (pair of lungs) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The pair of anatomical structures comprised of a left lung and right lung.") +AnnotationAssertion( "FMA:68877") AnnotationAssertion(rdfs:label "pair of lungs") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29891,15 +40346,54 @@ SubClassOf( ObjectExactCardinalit # Class: (respiration organ) +AnnotationAssertion(Annotation( "GO:0007585") "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.") +AnnotationAssertion( "SCTID:272626006") +AnnotationAssertion( "SPD:0000428") +AnnotationAssertion( "TGMA:0001247") AnnotationAssertion(rdfs:label "respiration organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (excreta) + +AnnotationAssertion(Annotation( "GO:0007588") Annotation( "http://orcid.org/0000-0002-6601-2165") "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity.") +AnnotationAssertion( "AEO:0000184") +AnnotationAssertion( "BTO:0000491") +AnnotationAssertion( "EHDAA2_RETIRED:0003184") +AnnotationAssertion( "ENVO:02000022") +AnnotationAssertion( "FMA:9674") +AnnotationAssertion( "galen:Excretion") +AnnotationAssertion(rdfs:label "excreta") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (blood) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FMA:9670") Annotation( "Wikipedia:Blood") Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/9") "A fluid that is composed of blood plasma and erythrocytes.") +AnnotationAssertion( "AAO:0000046") +AnnotationAssertion( "BTO:0000089") +AnnotationAssertion( "CALOHA:TS-0079") +AnnotationAssertion( "EFO:0000296") +AnnotationAssertion( "EHDAA2:0000176") +AnnotationAssertion( "EHDAA:418") +AnnotationAssertion( "EMAPA:16332") +AnnotationAssertion( "ENVO:02000027") +AnnotationAssertion( "EV:0100047") +AnnotationAssertion( "FMA:9670") +AnnotationAssertion( "GAID:965") +AnnotationAssertion( "MA:0000059") +AnnotationAssertion( "MESH:D001769") +AnnotationAssertion( "MIAA:0000315") +AnnotationAssertion( "NCIT:C12434") +AnnotationAssertion( "TAO:0000007") +AnnotationAssertion( "VHOG:0000224") +AnnotationAssertion( "Wikipedia:Blood") +AnnotationAssertion( "XAO:0000124") +AnnotationAssertion( "ZFA:0000007") +AnnotationAssertion( "galen:Blood") AnnotationAssertion(rdfs:label "blood") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29910,14 +40404,61 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (haemolymphatic fluid) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs.") +AnnotationAssertion( "CARO:0000081") AnnotationAssertion(rdfs:label "haemolymphatic fluid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (tetrapod frontal bone) + +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0000107") Annotation( "PMID:7914451") Annotation( "Wikipedia:Frontal_bone") "The bone forming the forehead and roof of the eye orbit.") +AnnotationAssertion( "AAO:0000206") +AnnotationAssertion( "EMAPA:19016") +AnnotationAssertion( "FMA:52734") +AnnotationAssertion( "GAID:226") +AnnotationAssertion( "MA:0001466") +AnnotationAssertion( "MESH:D005624") +AnnotationAssertion( "NCIT:C32635") +AnnotationAssertion( "SCTID:181793006") +AnnotationAssertion( "VSAO:0000208") +AnnotationAssertion( "Wikipedia:Frontal_bone") +AnnotationAssertion(rdfs:label "tetrapod frontal bone") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (atlanto-occipital joint) + +AnnotationAssertion(Annotation( "Wikipedia:Atlanto-occipital_joint") "The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital.") +AnnotationAssertion( "FMA:24939") +AnnotationAssertion( "NCIT:C32158") +AnnotationAssertion( "SCTID:361831006") +AnnotationAssertion( "Wikipedia:Atlanto-occipital_joint") +AnnotationAssertion( "ncithesaurus:Atlanto-occipital_Joint-Atlanto") +AnnotationAssertion(rdfs:label "atlanto-occipital joint") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (tendon sheath) +AnnotationAssertion(Annotation( "Wikipedia:Tendon_sheath") "A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath.") +AnnotationAssertion( "BTO:0000051") +AnnotationAssertion( "FMA:45087") +AnnotationAssertion( "FMA:76715") +AnnotationAssertion( "NCIT:C96299") +AnnotationAssertion( "SCTID:361885006") +AnnotationAssertion( "Wikipedia:Tendon_sheath") AnnotationAssertion(rdfs:label "tendon sheath") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29927,21 +40468,78 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (blastula) +AnnotationAssertion(Annotation( "Wikipedia:Blastula") "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.") +AnnotationAssertion( "BILA:0000059") +AnnotationAssertion( "BTO:0000128") +AnnotationAssertion( "GAID:1294") +AnnotationAssertion( "MESH:D036703") +AnnotationAssertion( "OGEM:000006") +AnnotationAssertion( "Wikipedia:Blastula") AnnotationAssertion(rdfs:label "blastula") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (colonic mucosa) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells.") +AnnotationAssertion( "BTO:0000271") +AnnotationAssertion( "CALOHA:TS-0164") +AnnotationAssertion( "EFO:0003038") +AnnotationAssertion( "EMAPA:27375") +AnnotationAssertion( "FMA:14984") +AnnotationAssertion( "FMA:85388") +AnnotationAssertion( "MA:0003194") +AnnotationAssertion( "SCTID:362157008") +AnnotationAssertion(rdfs:label "colonic mucosa") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (duodenal mucosa) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a duodenum [Automatically generated definition].") +AnnotationAssertion( "BTO:0000367") +AnnotationAssertion( "CALOHA:TS-0213") +AnnotationAssertion( "EMAPA:27235") +AnnotationAssertion( "FMA:14942") +AnnotationAssertion( "MA:0003207") +AnnotationAssertion( "SCTID:362146003") +AnnotationAssertion(rdfs:label "duodenal mucosa") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (gastric gland) +AnnotationAssertion(Annotation( "MGI:anna") "The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin.") +AnnotationAssertion( "BTO:0000503") +AnnotationAssertion( "EMAPA:27181") +AnnotationAssertion( "FMA:14919") AnnotationAssertion(rdfs:label "gastric gland") SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreatic juice) + +AnnotationAssertion(Annotation( "GO:0030157") "Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.") +AnnotationAssertion( "BTO:0000504") +AnnotationAssertion( "CALOHA:TS-2235") +AnnotationAssertion( "FMA:62973") +AnnotationAssertion( "GAID:1166") +AnnotationAssertion( "MESH:D010189") +AnnotationAssertion(rdfs:label "pancreatic juice") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (gut wall) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity).") +AnnotationAssertion( "BTO:0000547") +AnnotationAssertion( "FMA:45653") AnnotationAssertion(rdfs:label "gut wall") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29949,14 +40547,44 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (yellow bone marrow) +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/Yellow+Marrow") "Bone marrow in which the fat cells predominate in the meshes of the reticular network.") +AnnotationAssertion( "BTO:0000635") +AnnotationAssertion( "FMA:74596") +AnnotationAssertion( "SCTID:328639002") +AnnotationAssertion( "SCTID:5023006") AnnotationAssertion(rdfs:label "yellow bone marrow") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (intestinal gland) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm].") +AnnotationAssertion( "BTO:0000640") +AnnotationAssertion( "FMA:15052") +AnnotationAssertion( "SCTID:266297002") +AnnotationAssertion(rdfs:label "intestinal gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mucosa) +AnnotationAssertion(Annotation( "Wikipedia:Mucous_membrane") "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP].") +AnnotationAssertion( "AEO:0000199") +AnnotationAssertion( "BTO:0000886") +AnnotationAssertion( "CALOHA:TS-2031") +AnnotationAssertion( "EHDAA2_RETIRED:0003234") +AnnotationAssertion( "EV:0100382") +AnnotationAssertion( "FMA:85355") +AnnotationAssertion( "FMA:85358") +AnnotationAssertion( "GAID:297") +AnnotationAssertion( "MESH:D009092") +AnnotationAssertion( "NCIT:C13166") +AnnotationAssertion( "SCTID:361693009") +AnnotationAssertion( "Wikipedia:Mucous_membrane") +AnnotationAssertion( "galen:Mucosa") AnnotationAssertion(rdfs:label "mucosa") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29965,6 +40593,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (parenchyma) +AnnotationAssertion(Annotation( "Wikipedia:Parenchyma") "Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues.") +AnnotationAssertion( "EHDAA:3015") +AnnotationAssertion( "EHDAA:3905") +AnnotationAssertion( "EHDAA:3999") +AnnotationAssertion( "EHDAA:4005") +AnnotationAssertion( "EHDAA:6899") +AnnotationAssertion( "EHDAA:6903") +AnnotationAssertion( "EHDAA:6994") +AnnotationAssertion( "EHDAA:8086") +AnnotationAssertion( "EHDAA:9182") +AnnotationAssertion( "EHDAA:9190") +AnnotationAssertion( "EHDAA:9196") +AnnotationAssertion( "EHDAA:9202") +AnnotationAssertion( "FMA:45732") +AnnotationAssertion( "NCIT:C74601") +AnnotationAssertion( "Wikipedia:Parenchyma") AnnotationAssertion(rdfs:label "parenchyma") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29973,6 +40617,12 @@ DisjointClasses( (pharyngeal mucosa) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a pharynx [Automatically generated definition].") +AnnotationAssertion( "BTO:0001047") +AnnotationAssertion( "EMAPA:26957") +AnnotationAssertion( "FMA:55031") +AnnotationAssertion( "MA:0003143") +AnnotationAssertion( "SCTID:362121003") AnnotationAssertion(rdfs:label "pharyngeal mucosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29980,6 +40630,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (blastocyst) +AnnotationAssertion(Annotation( "GO:0001824") Annotation( "Wikipedia:Blastocyst") "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO].") +AnnotationAssertion( "BTO:0001099") +AnnotationAssertion( "CALOHA:TS-0076") +AnnotationAssertion( "EFO:0000295") +AnnotationAssertion( "EMAPA:36035") +AnnotationAssertion( "EV:0100394") +AnnotationAssertion( "FMA:83041") +AnnotationAssertion( "GAID:1153") +AnnotationAssertion( "MESH:D001755") +AnnotationAssertion( "NCIT:C13739") +AnnotationAssertion( "SCTID:308837009") +AnnotationAssertion( "Wikipedia:Blastocyst") AnnotationAssertion(rdfs:label "blastocyst") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -29991,6 +40653,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (red bone marrow) +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/red+marrow") "The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream.") +AnnotationAssertion( "BTO:0001160") +AnnotationAssertion( "FMA:74595") +AnnotationAssertion( "SCTID:328538003") +AnnotationAssertion( "SCTID:75330005") AnnotationAssertion(rdfs:label "red bone marrow") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -29999,6 +40666,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (syncytiotrophoblast) +AnnotationAssertion(Annotation( "Wikipedia:Syncytiotrophoblast") Annotation( "http://embryology.med.unsw.edu.au/Notes/placenta5.htm") "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated).") +AnnotationAssertion( "BTO:0001335") +AnnotationAssertion( "EHDAA:129") +AnnotationAssertion( "EHDAA:91") +AnnotationAssertion( "EMAPA:16068") +AnnotationAssertion( "FMA:83040") +AnnotationAssertion( "NCIT:C33918") +AnnotationAssertion( "SCTID:256965005") +AnnotationAssertion( "Wikipedia:Syncytiotrophoblast") AnnotationAssertion(rdfs:label "syncytiotrophoblast") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30006,13 +40682,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (maxillary nerve) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MP:0009799") Annotation( "Wikipedia:Maxillary_nerve") "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses.") +AnnotationAssertion( "AAO:0010670") +AnnotationAssertion( "BTO:0001378") +AnnotationAssertion( "EHDAA2:0002087") +AnnotationAssertion( "EMAPA:17799") +AnnotationAssertion( "FMA:52724") +AnnotationAssertion( "GAID:836") +AnnotationAssertion( "MA:0001103") +AnnotationAssertion( "MESH:D008442") +AnnotationAssertion( "SCTID:280211001") +AnnotationAssertion( "VHOG:0001346") +AnnotationAssertion( "Wikipedia:Maxillary_nerve") AnnotationAssertion(rdfs:label "maxillary nerve") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (tracheal mucosa) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a respiratory airway.") +AnnotationAssertion( "BTO:0001390") +AnnotationAssertion( "FMA:7471") +AnnotationAssertion( "SCTID:660006") AnnotationAssertion(rdfs:label "tracheal mucosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30020,7 +40711,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (musculature of body) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "VSAO:0000033") "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified].") +AnnotationAssertion( "AAO:0000307") +AnnotationAssertion( "BILA:0000088") +AnnotationAssertion( "BTO:0001369") +AnnotationAssertion( "BTO:0001485") +AnnotationAssertion( "EFO:0000801") +AnnotationAssertion( "FMA:72954") +AnnotationAssertion( "MA:0002888") +AnnotationAssertion( "MAT:0000025") +AnnotationAssertion( "MIAA:0000025") +AnnotationAssertion( "VSAO:0000033") +AnnotationAssertion( "XAO:0004042") AnnotationAssertion(rdfs:label "musculature of body") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30030,7 +40732,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lens cortex) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://www.thefreedictionary.com/lens+cortex") "Tissue that surrounds the lens nucleus.") +AnnotationAssertion( "BTO:0001632") +AnnotationAssertion( "CALOHA:TS-0542") +AnnotationAssertion( "FMA:58970") +AnnotationAssertion( "MESH:D007904") +AnnotationAssertion( "SCTID:280626006") AnnotationAssertion(rdfs:label "lens cortex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30041,7 +40748,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lens nucleus) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "BTO:0001633") "The core of the crystalline lens, surrounded by the cortex.") +AnnotationAssertion( "BTO:0001633") +AnnotationAssertion( "FMA:58971") +AnnotationAssertion( "MESH:D007907") +AnnotationAssertion( "SCTID:280628007") AnnotationAssertion(rdfs:label "lens nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30050,8 +40761,28 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (colonic epithelium) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a colon [Automatically generated definition].") +AnnotationAssertion( "BTO:0001709") +AnnotationAssertion( "CALOHA:TS-0163") +AnnotationAssertion( "EMAPA:18941") +AnnotationAssertion( "FMA:17302") +AnnotationAssertion( "MA:0003195") +AnnotationAssertion( "SCTID:42978003") +AnnotationAssertion( "TAO:0005128") +AnnotationAssertion( "ZFA:0005128") +AnnotationAssertion(rdfs:label "colonic epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (serous gland) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "http://www.siumed.edu/~dking2/intro/glands.htm") "A gland in which the principal secretory cells are serous secreting cells.") +AnnotationAssertion( "BTO:0001837") +AnnotationAssertion( "FMA:62889") +AnnotationAssertion( "Wikipedia:Serous_gland") AnnotationAssertion(rdfs:label "serous gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30061,21 +40792,64 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bronchial mucosa) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a bronchus [Automatically generated definition].") +AnnotationAssertion( "BTO:0001846") +AnnotationAssertion( "FMA:62652") +AnnotationAssertion( "SCTID:30802009") AnnotationAssertion(rdfs:label "bronchial mucosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mucous gland) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "http://www.siumed.edu/~dking2/intro/glands.htm") "A gland in which the principal secretory cells are mucus secreting cells.") +AnnotationAssertion( "AAO:0010601") +AnnotationAssertion( "BTO:0001979") +AnnotationAssertion( "FMA:62888") +AnnotationAssertion( "Wikipedia:Mucous_gland") +AnnotationAssertion(rdfs:label "mucous gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (artery wall) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical wall that is part of an artery [Automatically generated definition].") +AnnotationAssertion( "BTO:0002009") +AnnotationAssertion( "FMA:14155") +AnnotationAssertion( "galen:ArterialWall") AnnotationAssertion(rdfs:label "artery wall") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (trabecula) + +AnnotationAssertion(Annotation( "GO:0060343") Annotation( "Wikipedia:Trabecula") "A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP].") +AnnotationAssertion( "BTO:0002501") +AnnotationAssertion( "FMA:85273") +AnnotationAssertion( "Wikipedia:Trabecula") +AnnotationAssertion(rdfs:label "trabecula") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (secretion of exocrine gland) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A portion of organism substance that is produced by exocrine glands.") +AnnotationAssertion( "AEO:0001005") +AnnotationAssertion( "BTO:0002977") +AnnotationAssertion( "BTO:0002979") +AnnotationAssertion( "EMAPA:36535") +AnnotationAssertion( "FMA:9675") +AnnotationAssertion( "MA:0002504") +AnnotationAssertion( "MESH:D012634") +AnnotationAssertion( "NCIT:C34062") +AnnotationAssertion( "galen:Secretion") AnnotationAssertion(rdfs:label "secretion of exocrine gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30083,9 +40857,25 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (organism substance) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0001-9114-8737") "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.") +AnnotationAssertion( "AAO:0010839") +AnnotationAssertion( "AEO:0000004") +AnnotationAssertion( "BILA:0000004") +AnnotationAssertion( "CALOHA:TS-2101") +AnnotationAssertion( "CARO:0000004") +AnnotationAssertion( "EHDAA2:0003004") +AnnotationAssertion( "EMAPA:35178") +AnnotationAssertion( "FMA:9669") +AnnotationAssertion( "HAO:0000004") +AnnotationAssertion( "MA:0002450") +AnnotationAssertion( "NCIT:C13236") +AnnotationAssertion( "SPD:0000008") +AnnotationAssertion( "TAO:0001487") +AnnotationAssertion( "TGMA:0001824") +AnnotationAssertion( "VHOG:0001726") +AnnotationAssertion( "XAO:0004001") +AnnotationAssertion( "ZFA:0001487") +AnnotationAssertion( "galen:BodySubstance") AnnotationAssertion(rdfs:label "organism substance") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30093,18 +40883,37 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anatomical space) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0001-9114-8737") "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures.") +AnnotationAssertion( "AAO:0010110") +AnnotationAssertion( "AEO:0000005") +AnnotationAssertion( "BILA:0000005") +AnnotationAssertion( "CARO:0000005") +AnnotationAssertion( "EHDAA2:0003005") +AnnotationAssertion( "FMA:5897") +AnnotationAssertion( "HAO:0000005") +AnnotationAssertion( "NCIT:C94478") +AnnotationAssertion( "TAO:0001668") +AnnotationAssertion( "TGMA:0001825") +AnnotationAssertion( "VHOG:0001728") +AnnotationAssertion( "XAO:0003190") +AnnotationAssertion( "ZFA:0001643") AnnotationAssertion(rdfs:label "anatomical space") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (material anatomical entity) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0001-9114-8737") "Anatomical entity that has mass.") +AnnotationAssertion( "AAO:0010264") +AnnotationAssertion( "AEO:0000006") +AnnotationAssertion( "BILA:0000006") +AnnotationAssertion( "CARO:0000006") +AnnotationAssertion( "EHDAA2:0003006") +AnnotationAssertion( "FMA:67165") +AnnotationAssertion( "HAO:0000006") +AnnotationAssertion( "TAO:0001836") +AnnotationAssertion( "TGMA:0001826") +AnnotationAssertion( "VHOG:0001721") AnnotationAssertion(rdfs:label "material anatomical entity") SubClassOf( ) SubClassOf( ) @@ -30112,19 +40921,49 @@ DisjointClasses( (immaterial anatomical entity) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0001-9114-8737") "Anatomical entity that has no mass.") +AnnotationAssertion( "AAO:0010265") +AnnotationAssertion( "AEO:0000007") +AnnotationAssertion( "BILA:0000007") +AnnotationAssertion( "CARO:0000007") +AnnotationAssertion( "EHDAA2:0003007") +AnnotationAssertion( "FMA:67112") +AnnotationAssertion( "HAO:0000007") +AnnotationAssertion( "TAO:0001835") +AnnotationAssertion( "TGMA:0001827") +AnnotationAssertion( "VHOG:0001727") AnnotationAssertion(rdfs:label "immaterial anatomical entity") SubClassOf( ) SubClassOf( ) # Class: (anatomical system) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0000011") "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.") +AnnotationAssertion( "AAO:0000007") +AnnotationAssertion( "AEO:0000011") +AnnotationAssertion( "BILA:0000011") +AnnotationAssertion( "BIRNLEX:14") +AnnotationAssertion( "BSA:0000049") +AnnotationAssertion( "CALOHA:TS-2088") +AnnotationAssertion( "CARO:0000011") +AnnotationAssertion( "EHDAA2:0003011") +AnnotationAssertion( "EHDAA:392") +AnnotationAssertion( "EMAPA:16103") +AnnotationAssertion( "EV:0100000") +AnnotationAssertion( "FMA:7149") +AnnotationAssertion( "HAO:0000011") +AnnotationAssertion( "MA:0000003") +AnnotationAssertion( "NCIT:C12919") +AnnotationAssertion( "SCTID:278195005") +AnnotationAssertion( "TAO:0001439") +AnnotationAssertion( "TGMA:0001831") +AnnotationAssertion( "VHOG:0001725") +AnnotationAssertion( "WBbt:0005746") +AnnotationAssertion( "WBbt:0005763") +AnnotationAssertion( "Wikipedia:Organ_system") +AnnotationAssertion( "XAO:0003002") +AnnotationAssertion( "ZFA:0001439") +AnnotationAssertion( "galen:AnatomicalSystem") AnnotationAssertion(rdfs:label "anatomical system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30132,15 +40971,77 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (multicellular organism) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0000012") Annotation( "Wikipedia:Multi-cellular_organism") Annotation( "http://orcid.org/0000-0001-9114-8737") "Anatomical structure that is an individual member of a species and consists of more than one cell.") +AnnotationAssertion( "AAO:0010026") +AnnotationAssertion( "AEO:0000191") +AnnotationAssertion( "BILA:0000012") +AnnotationAssertion( "BIRNLEX:18") +AnnotationAssertion( "BSA:0000038") +AnnotationAssertion( "BTO:0000042") +AnnotationAssertion( "CARO:0000012") +AnnotationAssertion( "EFO:0002906") +AnnotationAssertion( "EHDAA2:0003103") +AnnotationAssertion( "EHDAA2:0003191") +AnnotationAssertion( "EHDAA:1") +AnnotationAssertion( "EMAPA:25765") +AnnotationAssertion( "EV:0100016") +AnnotationAssertion( "FMA:256135") +AnnotationAssertion( "HAO:0000012") +AnnotationAssertion( "NCIT:C13041") +AnnotationAssertion( "SCTID:243928005") +AnnotationAssertion( "TADS:0000001") +AnnotationAssertion( "TAO:0001094") +AnnotationAssertion( "TGMA:0001832") +AnnotationAssertion( "VHOG:0000671") +AnnotationAssertion( "WBbt:0007833") +AnnotationAssertion( "Wikipedia:Multi-cellular_organism") +AnnotationAssertion( "XAO:0003004") +AnnotationAssertion( "ZFA:0001094") +AnnotationAssertion( "galen:Organism") +AnnotationAssertion( "ncithesaurus:Whole_Organism") AnnotationAssertion(rdfs:label "multicellular organism") SubClassOf( ) +# Class: (compound organ component) + +AnnotationAssertion(Annotation( "CARO:0000019") Annotation( "http://orcid.org/0000-0001-9114-8737") "Multi-tissue structure that is part of a compound organ.") +AnnotationAssertion( "AAO:0010017") +AnnotationAssertion( "AEO:0000019") +AnnotationAssertion( "BILA:0000019") +AnnotationAssertion( "CARO:0000019") +AnnotationAssertion( "EHDAA2:0003019") +AnnotationAssertion( "HAO:0000019") +AnnotationAssertion( "TAO:0001489") +AnnotationAssertion( "TGMA:0001835") +AnnotationAssertion( "XAO:0003039") +AnnotationAssertion( "ZFA:0001489") +AnnotationAssertion(rdfs:label "compound organ component") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (female reproductive system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MP:0001119") Annotation( "Wikipedia:Female_genitalia") Annotation( "http://orcid.org/0000-0002-6601-2165") "The organs and associated structures associated with bearing offspring in a female animal.") +AnnotationAssertion( "BTO:0000083") +AnnotationAssertion( "CALOHA:TS-1303") +AnnotationAssertion( "EFO:0000969") +AnnotationAssertion( "EHDAA2:0000506") +AnnotationAssertion( "EHDAA:8116") +AnnotationAssertion( "EMAPA:17959") +AnnotationAssertion( "EV:0100110") +AnnotationAssertion( "FMA:45663") +AnnotationAssertion( "GAID:364") +AnnotationAssertion( "HAO:0000324") +AnnotationAssertion( "MA:0000381") +AnnotationAssertion( "MESH:D005836") +AnnotationAssertion( "MIAA:0000028") +AnnotationAssertion( "NCIT:C12402") +AnnotationAssertion( "SCTID:361386004") +AnnotationAssertion( "TGMA:0000635") +AnnotationAssertion( "VHOG:0000726") +AnnotationAssertion( "Wikipedia:Female_genitalia") +AnnotationAssertion( "WikipediaCategory:Female_reproductive_system") +AnnotationAssertion( "XAO:0000156") AnnotationAssertion(rdfs:label "female reproductive system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30148,31 +41049,78 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (organism subdivision) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0000032") Annotation( "CARO:DOS") Annotation( "http://orcid.org/0000-0001-9114-8737") "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument.") +AnnotationAssertion( "AAO:0010053") +AnnotationAssertion( "AEO:0000032") +AnnotationAssertion( "BILA:0000032") +AnnotationAssertion( "BIRNLEX:7") +AnnotationAssertion( "CALOHA:TS-2084") +AnnotationAssertion( "CARO:0000032") +AnnotationAssertion( "EFO:0000808") +AnnotationAssertion( "EHDAA2:0003032") +AnnotationAssertion( "EMAPA:36031") +AnnotationAssertion( "FMA:7153") +AnnotationAssertion( "HAO:0000032") +AnnotationAssertion( "MA:0002433") +AnnotationAssertion( "MAT:0000293") +AnnotationAssertion( "MESH:D001829") +AnnotationAssertion( "MIAA:0000293") +AnnotationAssertion( "NCIT:C32221") +AnnotationAssertion( "TAO:0001308") +AnnotationAssertion( "TGMA:0001840") +AnnotationAssertion( "VHOG:0001758") +AnnotationAssertion( "Wikipedia:Body_part") +AnnotationAssertion( "XAO:0003013") +AnnotationAssertion( "ZFA:0001308") +AnnotationAssertion( "galen:BodyPart") AnnotationAssertion(rdfs:label "organism subdivision") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (acellular anatomical structure) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0001-9114-8737") "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue.") +AnnotationAssertion( "AAO:0010268") +AnnotationAssertion( "AEO:0000040") +AnnotationAssertion( "BILA:0000040") +AnnotationAssertion( "CARO:0000040") +AnnotationAssertion( "EHDAA2:0003040") +AnnotationAssertion( "FMA:63863") +AnnotationAssertion( "HAO:0000040") +AnnotationAssertion( "TAO:0000382") +AnnotationAssertion( "TGMA:0001841") +AnnotationAssertion( "XAO:0003162") +AnnotationAssertion( "ZFA:0000382") AnnotationAssertion(rdfs:label "acellular anatomical structure") SubClassOf( ) # Class: (anatomical cluster) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FBbt:00007277") "Anatomical group whose component anatomical structures lie in close proximity to each other.") +AnnotationAssertion( "VHOG:0001737") AnnotationAssertion(rdfs:label "anatomical cluster") SubClassOf( ) # Class: (extraembryonic structure) +AnnotationAssertion(Annotation( "CARO:DOS") Annotation( "http://orcid.org/0000-0001-9114-8737") Annotation( "https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279") "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis.") +AnnotationAssertion( "AAO:0010020") +AnnotationAssertion( "AEO:0000042") +AnnotationAssertion( "BILA:0000042") +AnnotationAssertion( "CALOHA:TS-2119") +AnnotationAssertion( "CARO:0000042") +AnnotationAssertion( "EHDAA2:0003042") +AnnotationAssertion( "EHDAA:46") +AnnotationAssertion( "FMA:85537") +AnnotationAssertion( "HAO:0000042") +AnnotationAssertion( "NCIT:C34055") +AnnotationAssertion( "SCTID:314908006") +AnnotationAssertion( "TAO:0000020") +AnnotationAssertion( "TGMA:0001843") +AnnotationAssertion( "VHOG:0000292") +AnnotationAssertion( "XAO:0004005") +AnnotationAssertion( "ZFA:0000020") +AnnotationAssertion(rdfs:comment "see also conceptus extraembryonic component in EHDAA2.") AnnotationAssertion(rdfs:label "extraembryonic structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30180,9 +41128,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tissue) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0000043") "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation.") +AnnotationAssertion( "AAO:0000607") +AnnotationAssertion( "AAO:0010054") +AnnotationAssertion( "AEO:0000043") +AnnotationAssertion( "BILA:0000043") +AnnotationAssertion( "BIRNLEX:19") +AnnotationAssertion( "CALOHA:TS-2090") +AnnotationAssertion( "CARO:0000043") +AnnotationAssertion( "EHDAA2:0003043") +AnnotationAssertion( "EMAPA:35868") +AnnotationAssertion( "FMA:9637") +AnnotationAssertion( "HAO:0000043") +AnnotationAssertion( "MA:0003002") +AnnotationAssertion( "MESH:D014024") +AnnotationAssertion( "NCIT:C12801") +AnnotationAssertion( "TAO:0001477") +AnnotationAssertion( "TGMA:0001844") +AnnotationAssertion( "VHOG:0001757") +AnnotationAssertion( "WBbt:0005729") +AnnotationAssertion( "XAO:0003040") +AnnotationAssertion( "ZFA:0001477") +AnnotationAssertion( "galen:Tissue") AnnotationAssertion(rdfs:label "tissue") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30190,15 +41157,47 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (multi-tissue structure) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0000055") Annotation( "http://orcid.org/0000-0001-9114-8737") "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types.") +AnnotationAssertion( "AAO:0010048") +AnnotationAssertion( "AEO:0000055") +AnnotationAssertion( "BILA:0000055") +AnnotationAssertion( "CARO:0000055") +AnnotationAssertion( "EHDAA2:0003055") +AnnotationAssertion( "HAO:0000055") +AnnotationAssertion( "TAO:0001488") +AnnotationAssertion( "TGMA:0001847") +AnnotationAssertion( "VHOG:0001762") +AnnotationAssertion( "XAO:0003037") +AnnotationAssertion( "ZFA:0001488") AnnotationAssertion(rdfs:label "multi-tissue structure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (epithelium) +AnnotationAssertion(Annotation( "Wikipedia:Epithelium") Annotation( "http://orcid.org/0000-0001-9114-8737") "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO].") +AnnotationAssertion( "AAO:0000144") +AnnotationAssertion( "AAO:0010055") +AnnotationAssertion( "AEO:0000066") +AnnotationAssertion( "BILA:0000066") +AnnotationAssertion( "BTO:0000416") +AnnotationAssertion( "CALOHA:TS-0288") +AnnotationAssertion( "CARO:0000066") +AnnotationAssertion( "EHDAA2:0003066") +AnnotationAssertion( "EMAPA:32738") +AnnotationAssertion( "FMA:9639") +AnnotationAssertion( "GAID:402") +AnnotationAssertion( "HAO:0000066") +AnnotationAssertion( "MA:0003060") +AnnotationAssertion( "MESH:D004848") +AnnotationAssertion( "NCIT:C12710") +AnnotationAssertion( "SCTID:31610004") +AnnotationAssertion( "TAO:0001486") +AnnotationAssertion( "VHOG:0000387") +AnnotationAssertion( "Wikipedia:Epithelium") +AnnotationAssertion( "XAO:0003045") +AnnotationAssertion( "ZFA:0001486") +AnnotationAssertion(rdfs:comment "Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it?") AnnotationAssertion(rdfs:label "epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) EquivalentClasses( ObjectUnionOf( )) @@ -30210,23 +41209,79 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (simple cuboidal epithelium) +AnnotationAssertion(Annotation( "Wikipedia:Simple_cuboidal_epithelium") Annotation( "http://orcid.org/0000-0001-9114-8737") "Unilaminar epithelium that consists of a single layer of cuboidal cells.") +AnnotationAssertion( "AAO:0010064") +AnnotationAssertion( "AEO:0000067") +AnnotationAssertion( "BILA:0000067") +AnnotationAssertion( "CARO:0000067") +AnnotationAssertion( "EHDAA2:0003067") +AnnotationAssertion( "FMA:45566") +AnnotationAssertion( "HAO:0000067") +AnnotationAssertion( "NCIT:C33553") +AnnotationAssertion( "TAO:0001497") +AnnotationAssertion( "Wikipedia:Simple_cuboidal_epithelium") +AnnotationAssertion( "XAO:0004009") +AnnotationAssertion( "ZFA:0001497") AnnotationAssertion(rdfs:label "simple cuboidal epithelium") SubClassOf( ) SubClassOf( ) # Class: (simple columnar epithelium) +AnnotationAssertion(Annotation( "FMA:FMA") Annotation( "Wikipedia:Simple_columnar_epithelium") Annotation( "http://orcid.org/0000-0001-9114-8737") "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA].") +AnnotationAssertion( "AAO:0010063") +AnnotationAssertion( "AEO:0000068") +AnnotationAssertion( "BILA:0000068") +AnnotationAssertion( "CARO:0000068") +AnnotationAssertion( "EHDAA2_RETIRED:0003068") +AnnotationAssertion( "FMA:45567") +AnnotationAssertion( "HAO:0000068") +AnnotationAssertion( "NCIT:C33552") +AnnotationAssertion( "SCTID:32210007") +AnnotationAssertion( "TAO:0001496") +AnnotationAssertion( "Wikipedia:Simple_columnar_epithelium") +AnnotationAssertion( "XAO:0004008") +AnnotationAssertion( "ZFA:0001496") AnnotationAssertion(rdfs:label "simple columnar epithelium") SubClassOf( ) SubClassOf( ) # Class: (multilaminar epithelium) +AnnotationAssertion(Annotation( "FMA:FMA") Annotation( "Wikipedia:Stratified_epithelium") Annotation( "http://orcid.org/0000-0001-9114-8737") "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA].") +AnnotationAssertion( "AAO:0010059") +AnnotationAssertion( "AEO:0000069") +AnnotationAssertion( "BILA:0000069") +AnnotationAssertion( "BTO:0002074") +AnnotationAssertion( "CARO:0000069") +AnnotationAssertion( "EHDAA2:0003069") +AnnotationAssertion( "FMA:45562") +AnnotationAssertion( "HAO:0000069") +AnnotationAssertion( "NCIT:C33622") +AnnotationAssertion( "SCTID:309044005") +AnnotationAssertion( "TAO:0001494") +AnnotationAssertion( "Wikipedia:Stratified_epithelium") +AnnotationAssertion( "XAO:0004006") +AnnotationAssertion( "ZFA:0001494") AnnotationAssertion(rdfs:label "multilaminar epithelium") SubClassOf( ) # Class: (simple squamous epithelium) +AnnotationAssertion(Annotation( "FMA:45565") Annotation( "Wikipedia:Simple_squamous_epithelium") Annotation( "http://orcid.org/0000-0001-9114-8737") "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA].") +AnnotationAssertion( "AAO:0010066") +AnnotationAssertion( "AEO:0000070") +AnnotationAssertion( "BILA:0000070") +AnnotationAssertion( "BTO:0002073") +AnnotationAssertion( "CARO:0000070") +AnnotationAssertion( "EHDAA2:0003070") +AnnotationAssertion( "FMA:45565") +AnnotationAssertion( "HAO:0000070") +AnnotationAssertion( "NCIT:C13178") +AnnotationAssertion( "TAO:0001498") +AnnotationAssertion( "Wikipedia:Simple_squamous_epithelium") +AnnotationAssertion( "XAO:0004010") +AnnotationAssertion( "ZFA:0001498") AnnotationAssertion(rdfs:label "simple squamous epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30234,11 +41289,35 @@ SubClassOf( (atypical epithelium) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0001-9114-8737") "Epithelium that consists of epithelial cells not arranged in one ore more layers.") +AnnotationAssertion( "AAO:0010057") +AnnotationAssertion( "AEO:0000071") +AnnotationAssertion( "BILA:0000071") +AnnotationAssertion( "CARO:0000071") +AnnotationAssertion( "EHDAA2:0003071") +AnnotationAssertion( "FMA:61741") +AnnotationAssertion( "HAO:0000071") +AnnotationAssertion( "TAO:0001493") +AnnotationAssertion( "XAO:0004004") +AnnotationAssertion( "ZFA:0001493") AnnotationAssertion(rdfs:label "atypical epithelium") SubClassOf( ) # Class: (cavitated compound organ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0001-9114-8737") "Compound organ that contains one or more macroscopic anatomical spaces.") +AnnotationAssertion( "AAO:0010016") +AnnotationAssertion( "AEO:0000072") +AnnotationAssertion( "BILA:0000072") +AnnotationAssertion( "CARO:0000072") +AnnotationAssertion( "EHDAA2:0003072") +AnnotationAssertion( "FMA:55671") +AnnotationAssertion( "HAO:0000072") +AnnotationAssertion( "TAO:0001490") +AnnotationAssertion( "TGMA:0001857") +AnnotationAssertion( "VHOG:0001730") +AnnotationAssertion( "XAO:0003165") +AnnotationAssertion( "ZFA:0001490") AnnotationAssertion(rdfs:label "cavitated compound organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30246,11 +41325,49 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (unilaminar epithelium) +AnnotationAssertion(Annotation( "FMA:45561") Annotation( "http://orcid.org/0000-0001-9114-8737") "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA].") +AnnotationAssertion( "AAO:0010062") +AnnotationAssertion( "AEO:0000073") +AnnotationAssertion( "BILA:0000073") +AnnotationAssertion( "BTO:0002073") +AnnotationAssertion( "CARO:0000073") +AnnotationAssertion( "EHDAA2:0003073") +AnnotationAssertion( "FMA:45561") +AnnotationAssertion( "HAO:0000073") +AnnotationAssertion( "NCIT:C33554") +AnnotationAssertion( "SCTID:309043004") +AnnotationAssertion( "TAO:0001495") +AnnotationAssertion( "XAO:0004007") +AnnotationAssertion( "ZFA:0001495") AnnotationAssertion(rdfs:label "unilaminar epithelium") SubClassOf( ) +# Class: (mucus) + +AnnotationAssertion(Annotation( "Wikipedia:Mucus") "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water.") +AnnotationAssertion( "CALOHA:TS-2144") +AnnotationAssertion( "ENVO:02000040") +AnnotationAssertion( "FMA:66938") +AnnotationAssertion( "GAID:1164") +AnnotationAssertion( "MESH:D009093") +AnnotationAssertion( "NCIT:C13259") +AnnotationAssertion( "Wikipedia:Mucus") +AnnotationAssertion( "galen:Mucus") +AnnotationAssertion(rdfs:label "mucus") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (thoracic segment of trunk) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Subdivision of trunk that lies between the head and the abdomen.") +AnnotationAssertion( "EMAPA:35862") +AnnotationAssertion( "FMA:259209") +AnnotationAssertion( "MA:0000022") +AnnotationAssertion( "SCTID:302551006") +AnnotationAssertion( "Wikipedia:Thorax") AnnotationAssertion(rdfs:label "thoracic segment of trunk") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30259,6 +41376,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdomen) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column.") +AnnotationAssertion( "BTO:0000020") +AnnotationAssertion( "CALOHA:TS-0001") +AnnotationAssertion( "EFO:0000968") +AnnotationAssertion( "EMAPA:35102") +AnnotationAssertion( "EV:0100011") +AnnotationAssertion( "FMA:9577") +AnnotationAssertion( "GAID:16") +AnnotationAssertion( "MA:0000029") +AnnotationAssertion( "MAT:0000298") +AnnotationAssertion( "MESH:D000005") +AnnotationAssertion( "MIAA:0000298") +AnnotationAssertion( "SCTID:302553009") +AnnotationAssertion( "Wikipedia:Abdomen") +AnnotationAssertion( "galen:Abdomen") AnnotationAssertion(rdfs:label "abdomen") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30266,6 +41398,31 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (embryo) +AnnotationAssertion(Annotation( "BTO:0000379") Annotation( "FB:FBrf0039741") Annotation( "FB:FBrf0041814") Annotation( "GO:0009790") Annotation( "Wikipedia:Embryo") "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.") +AnnotationAssertion( "AAO:0011035") +AnnotationAssertion( "AEO:0000169") +AnnotationAssertion( "BILA:0000056") +AnnotationAssertion( "BSA:0000039") +AnnotationAssertion( "BTO:0000379") +AnnotationAssertion( "CALOHA:TS-0229") +AnnotationAssertion( "EFO:0001367") +AnnotationAssertion( "EHDAA2:0000002") +AnnotationAssertion( "EHDAA2_RETIRED:0003236") +AnnotationAssertion( "EHDAA:38") +AnnotationAssertion( "EMAPA:16039") +AnnotationAssertion( "FMA:69068") +AnnotationAssertion( "GAID:963") +AnnotationAssertion( "MAT:0000226") +AnnotationAssertion( "MESH:D004622") +AnnotationAssertion( "MIAA:0000019") +AnnotationAssertion( "NCIT:C28147") +AnnotationAssertion( "OGEM:000001") +AnnotationAssertion( "SCTID:57991002") +AnnotationAssertion( "VHOG:0001766") +AnnotationAssertion( "Wikipedia:Embryo") +AnnotationAssertion( "XAO:0000113") +AnnotationAssertion( "ZFA:0000103") +AnnotationAssertion( "http://neurolex.org/wiki/Category:Embryonic_organism") AnnotationAssertion(rdfs:label "embryo") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30274,12 +41431,50 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (germ layer) +AnnotationAssertion(Annotation( "Wikipedia:Germ_layer") Annotation( "https://github.com/obophenotype/uberon/issues/203") "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm.") +AnnotationAssertion( "AAO:0000480") +AnnotationAssertion( "BILA:0000035") +AnnotationAssertion( "BTO:0000556") +AnnotationAssertion( "EMAPA:36033") +AnnotationAssertion( "FMA:69069") +AnnotationAssertion( "GAID:1303") +AnnotationAssertion( "MESH:D005855") +AnnotationAssertion( "NCIT:C12950") +AnnotationAssertion( "NCIT:C54105") +AnnotationAssertion( "TAO:0001122") +AnnotationAssertion( "VHOG:0001223") +AnnotationAssertion( "Wikipedia:Germ_layer") +AnnotationAssertion( "XAO:0003011") +AnnotationAssertion( "ZFA:0001122") +AnnotationAssertion(rdfs:comment "Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest]") AnnotationAssertion(rdfs:label "germ layer") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (ectoderm) +AnnotationAssertion(Annotation( "Wikipedia:Ectoderm") "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.") +AnnotationAssertion( "AAO:0000137") +AnnotationAssertion( "BILA:0000036") +AnnotationAssertion( "BTO:0000315") +AnnotationAssertion( "CALOHA:TS-0216") +AnnotationAssertion( "EFO:0000414") +AnnotationAssertion( "EHDAA2:0000428") +AnnotationAssertion( "EMAPA:16069") +AnnotationAssertion( "EV:0100003") +AnnotationAssertion( "FMA:69070") +AnnotationAssertion( "GAID:1304") +AnnotationAssertion( "MAT:0000155") +AnnotationAssertion( "MAT:0000173") +AnnotationAssertion( "MESH:D004475") +AnnotationAssertion( "MIAA:0000173") +AnnotationAssertion( "NCIT:C12703") +AnnotationAssertion( "SCTID:362851007") +AnnotationAssertion( "TAO:0000016") +AnnotationAssertion( "VHOG:0000153") +AnnotationAssertion( "Wikipedia:Ectoderm") +AnnotationAssertion( "XAO:0000001") +AnnotationAssertion( "ZFA:0000016") AnnotationAssertion(rdfs:label "ectoderm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30287,6 +41482,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endoderm) +AnnotationAssertion(Annotation( "Wikipedia:Endoderm") "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.") +AnnotationAssertion( "AAO:0000139") +AnnotationAssertion( "BILA:0000038") +AnnotationAssertion( "BTO:0000800") +AnnotationAssertion( "CALOHA:TS-0273") +AnnotationAssertion( "EFO:0002545") +AnnotationAssertion( "EHDAA2:0000436") +AnnotationAssertion( "EMAPA:16062") +AnnotationAssertion( "EV:0100005") +AnnotationAssertion( "FMA:69071") +AnnotationAssertion( "GAID:1305") +AnnotationAssertion( "MAT:0000175") +AnnotationAssertion( "MESH:D004707") +AnnotationAssertion( "MIAA:0000175") +AnnotationAssertion( "NCIT:C12706") +AnnotationAssertion( "SCTID:362855003") +AnnotationAssertion( "TAO:0000017") +AnnotationAssertion( "VHOG:0000154") +AnnotationAssertion( "Wikipedia:Endoderm") +AnnotationAssertion( "XAO:0000090") +AnnotationAssertion( "ZFA:0000017") AnnotationAssertion(rdfs:label "endoderm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30294,6 +41510,30 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesoderm) +AnnotationAssertion(Annotation( "Wikipedia:Mesoderm") "The middle germ layer of the embryo, between the endoderm and ectoderm.") +AnnotationAssertion( "AAO:0000304") +AnnotationAssertion( "BILA:0000037") +AnnotationAssertion( "BTO:0000839") +AnnotationAssertion( "CALOHA:TS-0623") +AnnotationAssertion( "EFO:0001981") +AnnotationAssertion( "EHDAA2:0001128") +AnnotationAssertion( "EHDAA:124") +AnnotationAssertion( "EHDAA:160") +AnnotationAssertion( "EHDAA:183") +AnnotationAssertion( "EMAPA:16083") +AnnotationAssertion( "EV:0100006") +AnnotationAssertion( "FMA:69072") +AnnotationAssertion( "GAID:522") +AnnotationAssertion( "MAT:0000174") +AnnotationAssertion( "MESH:D008648") +AnnotationAssertion( "MIAA:0000174") +AnnotationAssertion( "NCIT:C12750") +AnnotationAssertion( "SCTID:362854004") +AnnotationAssertion( "TAO:0000041") +AnnotationAssertion( "VHOG:0000152") +AnnotationAssertion( "Wikipedia:Mesoderm") +AnnotationAssertion( "XAO:0000050") +AnnotationAssertion( "ZFA:0000041") AnnotationAssertion(rdfs:label "mesoderm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30301,15 +41541,68 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (stomodeum) +AnnotationAssertion(Annotation( "Wikipedia:Stomodeum") Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/326") "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity.") +AnnotationAssertion( "BTO:0004224") +AnnotationAssertion( "EHDAA2:0001929") +AnnotationAssertion( "EMAPA:16263") +AnnotationAssertion( "FMA:295846") +AnnotationAssertion( "NCIT:C34306") +AnnotationAssertion( "TAO:0001290") +AnnotationAssertion( "TGMA:0000135") +AnnotationAssertion( "Wikipedia:Stomodeum") +AnnotationAssertion( "XAO:0000269") +AnnotationAssertion( "ZFA:0001290") AnnotationAssertion(rdfs:label "stomodeum") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (proctodeum) + +AnnotationAssertion(Annotation( "ZFA:0000066") Annotation( "https://github.com/obophenotype/uberon/issues/685") Annotation( "https://sourceforge.net/p/fbbtdv/tickets/52") "Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract.") +AnnotationAssertion( "AAO:0011087") +AnnotationAssertion( "EHDAA2:0000121") +AnnotationAssertion( "EMAPA:25038") +AnnotationAssertion( "NCIT:C34278") +AnnotationAssertion( "TAO:0000066") +AnnotationAssertion( "VHOG:0000139") +AnnotationAssertion( "Wikipedia:Proctodeum") +AnnotationAssertion( "XAO:0001019") +AnnotationAssertion( "ZFA:0000066") +AnnotationAssertion(rdfs:label "proctodeum") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (stomach) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Stomach") Annotation( "https://orcid.org/0000-0002-6601-2165") "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium.") +AnnotationAssertion( "AAO:0000579") +AnnotationAssertion( "ANISEED:1235297") +AnnotationAssertion( "BTO:0001307") +AnnotationAssertion( "CALOHA:TS-0980") +AnnotationAssertion( "EFO:0000837") +AnnotationAssertion( "EHDAA2:0001915") +AnnotationAssertion( "EHDAA:2993") +AnnotationAssertion( "EMAPA:17021") +AnnotationAssertion( "EV:0100070") +AnnotationAssertion( "FMA:7148") +AnnotationAssertion( "GAID:293") +AnnotationAssertion( "MA:0000353") +AnnotationAssertion( "MAT:0000051") +AnnotationAssertion( "MESH:D013270") +AnnotationAssertion( "MIAA:0000051") +AnnotationAssertion( "NCIT:C12391") +AnnotationAssertion( "SCTID:181246003") +AnnotationAssertion( "TAO:0002121") +AnnotationAssertion( "VHOG:0000408") +AnnotationAssertion( "Wikipedia:Stomach") +AnnotationAssertion( "XAO:0000128") +AnnotationAssertion( "galen:Stomach") AnnotationAssertion(rdfs:label "stomach") SubClassOf( ) SubClassOf( ) @@ -30320,7 +41613,25 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aorta) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MESH:A07.231.114.056") Annotation( "MP:0000272") Annotation( "Wikipedia:Aorta") Annotation( "http://orcid.org/0000-0002-6601-2165") "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation.") +AnnotationAssertion( "AAO:0010213") +AnnotationAssertion( "BTO:0000135") +AnnotationAssertion( "CALOHA:TS-0046") +AnnotationAssertion( "EFO:0000265") +AnnotationAssertion( "EMAPA:18601") +AnnotationAssertion( "EV:0100027") +AnnotationAssertion( "FMA:3734") +AnnotationAssertion( "GAID:469") +AnnotationAssertion( "MA:0000062") +AnnotationAssertion( "MAT:0000035") +AnnotationAssertion( "MESH:D001011") +AnnotationAssertion( "MIAA:0000035") +AnnotationAssertion( "NCIT:C12669") +AnnotationAssertion( "SCTID:181298001") +AnnotationAssertion( "VHOG:0001523") +AnnotationAssertion( "Wikipedia:Aorta") +AnnotationAssertion( "XAO:0003010") +AnnotationAssertion( "galen:Aorta") AnnotationAssertion(rdfs:label "aorta") SubClassOf( ) SubClassOf( ) @@ -30330,7 +41641,31 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Heart") Annotation( "http://orcid.org/0000-0002-6601-2165") "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ.") +AnnotationAssertion( "AAO:0010210") +AnnotationAssertion( "BILA:0000020") +AnnotationAssertion( "BTO:0000562") +AnnotationAssertion( "CALOHA:TS-0445") +AnnotationAssertion( "EFO:0000815") +AnnotationAssertion( "EHDAA2:0000738") +AnnotationAssertion( "EHDAA:420") +AnnotationAssertion( "EMAPA:16105") +AnnotationAssertion( "EV:0100018") +AnnotationAssertion( "FMA:7088") +AnnotationAssertion( "GAID:174") +AnnotationAssertion( "MA:0000072") +AnnotationAssertion( "MAT:0000036") +AnnotationAssertion( "MESH:D006321") +AnnotationAssertion( "MIAA:0000036") +AnnotationAssertion( "NCIT:C12727") +AnnotationAssertion( "SCTID:302509004") +AnnotationAssertion( "TAO:0000114") +AnnotationAssertion( "VHOG:0000276") +AnnotationAssertion( "Wikipedia:Heart") +AnnotationAssertion( "XAO:0000064") +AnnotationAssertion( "ZFA:0000114") +AnnotationAssertion( "galen:Heart") +AnnotationAssertion(rdfs:comment "Taxon notes:\" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)\" DOI:10.1101/gad.1485706") AnnotationAssertion(rdfs:label "heart") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30345,6 +41680,24 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endocrine system) +AnnotationAssertion(Annotation( "NLM:endocrine+system") Annotation( "Wikipedia:Endocrine_system") "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.") +AnnotationAssertion( "AAO:0010279") +AnnotationAssertion( "CALOHA:TS-1301") +AnnotationAssertion( "EFO:0002969") +AnnotationAssertion( "EHDAA2:0002224") +AnnotationAssertion( "EMAPA:35306") +AnnotationAssertion( "EV:0100128") +AnnotationAssertion( "FMA:9668") +AnnotationAssertion( "GAID:439") +AnnotationAssertion( "MA:0000012") +AnnotationAssertion( "MESH:D004703") +AnnotationAssertion( "NCIT:C12705") +AnnotationAssertion( "SCTID:278876000") +AnnotationAssertion( "TAO:0001158") +AnnotationAssertion( "VHOG:0000098") +AnnotationAssertion( "Wikipedia:Endocrine_system") +AnnotationAssertion( "XAO:0000158") +AnnotationAssertion( "ZFA:0001158") AnnotationAssertion(rdfs:label "endocrine system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30357,16 +41710,51 @@ DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) # Class: (brain) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Brain") Annotation( "https://github.com/obophenotype/uberon/issues/300") "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].") +AnnotationAssertion( "AAO:0010478") +AnnotationAssertion( "ABA:Brain") +AnnotationAssertion( "BAMS:Br") +AnnotationAssertion( "BAMS:Brain") +AnnotationAssertion( "BILA:0000135") +AnnotationAssertion( "BIRNLEX:796") +AnnotationAssertion( "BTO:0000142") +AnnotationAssertion( "CALOHA:TS-0095") +AnnotationAssertion( "DHBA:10155") +AnnotationAssertion( "EFO:0000302") +AnnotationAssertion( "EHDAA2:0000183") +AnnotationAssertion( "EHDAA:2641") +AnnotationAssertion( "EHDAA:6485") +AnnotationAssertion( "EMAPA:16894") +AnnotationAssertion( "EV:0100164") +AnnotationAssertion( "FMA:50801") +AnnotationAssertion( "GAID:571") +AnnotationAssertion( "HBA:4005") +AnnotationAssertion( "MA:0000168") +AnnotationAssertion( "MAT:0000098") +AnnotationAssertion( "MBA:8") +AnnotationAssertion( "MBA:997") +AnnotationAssertion( "MESH:D001921") +AnnotationAssertion( "MIAA:0000098") +AnnotationAssertion( "NCIT:C12439") +AnnotationAssertion( "PBA:3999") +AnnotationAssertion( "SCTID:258335003") +AnnotationAssertion( "TAO:0000008") +AnnotationAssertion( "VHOG:0000157") +AnnotationAssertion( "Wikipedia:Brain") +AnnotationAssertion( "XAO:0000010") +AnnotationAssertion( "ZFA:0000008") +AnnotationAssertion( "galen:Brain") AnnotationAssertion(rdfs:label "brain") SubClassOf( ) SubClassOf( ) @@ -30379,6 +41767,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lamina) +AnnotationAssertion(Annotation( "Wikipedia:Lamina_of_the_vertebral_arch") "Any thin layer or plate.") +AnnotationAssertion( "Wikipedia:Lamina_of_the_vertebral_arch") AnnotationAssertion(rdfs:label "lamina") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30386,7 +41776,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nerve of cervical vertebra) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Cervical_nerves") "The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted].") +AnnotationAssertion( "BAMS:cern") +AnnotationAssertion( "FMA:5859") +AnnotationAssertion( "NCIT:C32299") +AnnotationAssertion( "NLXANAT:20090207") +AnnotationAssertion( "SCTID:360497008") +AnnotationAssertion( "Wikipedia:Cervical_nerves") +AnnotationAssertion( "neuronames:2351") +AnnotationAssertion(rdfs:comment "Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP]") AnnotationAssertion(rdfs:label "nerve of cervical vertebra") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30394,6 +41792,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (head sensillum) +AnnotationAssertion( "MAT:0000204") +AnnotationAssertion( "MIAA:0000204") AnnotationAssertion(rdfs:label "head sensillum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30401,7 +41801,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cornea) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MESH:A09.371.060.217") Annotation( "MP:0001312") "The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure.") +AnnotationAssertion( "AAO:0010344") +AnnotationAssertion( "BTO:0000286") +AnnotationAssertion( "CALOHA:TS-0171") +AnnotationAssertion( "EFO:0000377") +AnnotationAssertion( "EHDAA2:0000316") +AnnotationAssertion( "EHDAA:10199") +AnnotationAssertion( "EMAPA:17161") +AnnotationAssertion( "EV:0100341") +AnnotationAssertion( "FMA:58238") +AnnotationAssertion( "GAID:892") +AnnotationAssertion( "MA:0000266") +AnnotationAssertion( "MESH:D003315") +AnnotationAssertion( "NCIT:C12342") +AnnotationAssertion( "SCTID:181162001") +AnnotationAssertion( "TAO:0000640") +AnnotationAssertion( "VHOG:0000164") +AnnotationAssertion( "Wikipedia:Cornea") +AnnotationAssertion( "XAO:0000180") +AnnotationAssertion( "ZFA:0000640") AnnotationAssertion(rdfs:label "cornea") SubClassOf( ) SubClassOf( ) @@ -30419,7 +41838,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lens of camera-type eye) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Lens_(anatomy)") Annotation( "http://orcid.org/0000-0002-6601-2165") "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina.") +AnnotationAssertion( "AAO:0010348") +AnnotationAssertion( "BTO:0000723") +AnnotationAssertion( "CALOHA:TS-0545") +AnnotationAssertion( "EHDAA:9057") +AnnotationAssertion( "EMAPA:17838") +AnnotationAssertion( "EV:0100343") +AnnotationAssertion( "FMA:58241") +AnnotationAssertion( "MA:0000275") +AnnotationAssertion( "MAT:0000141") +AnnotationAssertion( "MESH:D007908") +AnnotationAssertion( "MIAA:0000141") +AnnotationAssertion( "NCIT:C12743") +AnnotationAssertion( "RETIRED_EHDAA2:0000975") +AnnotationAssertion( "SCTID:181169005") +AnnotationAssertion( "TAO:0000035") +AnnotationAssertion( "VHOG:0000169") +AnnotationAssertion( "Wikipedia:Lens_(anatomy)") +AnnotationAssertion( "XAO:0000008") +AnnotationAssertion( "ZFA:0000035") +AnnotationAssertion(rdfs:comment "The lens is avascular and nourished by diffusion from the aqueous and vitreous humors.") AnnotationAssertion(rdfs:label "lens of camera-type eye") SubClassOf( ) SubClassOf( ) @@ -30430,7 +41869,34 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (retina) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Retina") Annotation( "ZFIN:curator") "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.") +AnnotationAssertion( "AAO:0010352") +AnnotationAssertion( "BAMS:R") +AnnotationAssertion( "BIRNLEX:1153") +AnnotationAssertion( "BTO:0001175") +AnnotationAssertion( "CALOHA:TS-0865") +AnnotationAssertion( "EFO:0000832") +AnnotationAssertion( "EHDAA2:0001627") +AnnotationAssertion( "EHDAA:4757") +AnnotationAssertion( "EMAPA:17168") +AnnotationAssertion( "EV:0100348") +AnnotationAssertion( "FMA:58301") +AnnotationAssertion( "GAID:755") +AnnotationAssertion( "MA:0000276") +AnnotationAssertion( "MAT:0000142") +AnnotationAssertion( "MBA:304325711") +AnnotationAssertion( "MESH:D012160") +AnnotationAssertion( "MIAA:0000142") +AnnotationAssertion( "NCIT:C12343") +AnnotationAssertion( "NIFSTD_RETIRED:birnlex_1156") +AnnotationAssertion( "SCTID:181171005") +AnnotationAssertion( "TAO:0000152") +AnnotationAssertion( "VHOG:0000229") +AnnotationAssertion( "Wikipedia:Retina") +AnnotationAssertion( "XAO:0000009") +AnnotationAssertion( "ZFA:0000152") +AnnotationAssertion( "neuronames:1862") +AnnotationAssertion(rdfs:comment "Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods") AnnotationAssertion(rdfs:label "retina") SubClassOf( ) SubClassOf( ) @@ -30443,7 +41909,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (eye) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An organ that detects light.") +AnnotationAssertion( "BILA:0000017") +AnnotationAssertion( "BTO:0000439") +AnnotationAssertion( "CALOHA:TS-0309") +AnnotationAssertion( "EFO:0000827") +AnnotationAssertion( "EV:0100336") +AnnotationAssertion( "GAID:69") +AnnotationAssertion( "MAT:0000140") +AnnotationAssertion( "MESH:D005123") +AnnotationAssertion( "MIAA:0000140") +AnnotationAssertion( "Wikipedia:Eye") AnnotationAssertion(rdfs:label "eye") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30453,6 +41929,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ommatidium) +AnnotationAssertion(Annotation( "PMID:21062451") "The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells.") +AnnotationAssertion( "BTO:0001922") +AnnotationAssertion( "HAO:0000666") +AnnotationAssertion( "MAT:0000143") +AnnotationAssertion( "MIAA:0000143") +AnnotationAssertion( "Wikipedia:Ommatidium") AnnotationAssertion(rdfs:label "ommatidium") SubClassOf( ) SubClassOf( ) @@ -30460,6 +41942,23 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neck) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column.") +AnnotationAssertion( "AEO:0000108") +AnnotationAssertion( "BTO:0000420") +AnnotationAssertion( "CALOHA:TS-2045") +AnnotationAssertion( "EFO:0000967") +AnnotationAssertion( "EHDAA2:0003108") +AnnotationAssertion( "EMAPA:35587") +AnnotationAssertion( "FMA:7155") +AnnotationAssertion( "GAID:86") +AnnotationAssertion( "MA:0000024") +AnnotationAssertion( "MAT:0000297") +AnnotationAssertion( "MESH:D009333") +AnnotationAssertion( "MIAA:0000297") +AnnotationAssertion( "NCIT:C13063") +AnnotationAssertion( "SCTID:302550007") +AnnotationAssertion( "Wikipedia:Neck") +AnnotationAssertion( "galen:Neck") AnnotationAssertion(rdfs:label "neck") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30468,6 +41967,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pleura) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0010820") Annotation( "UBERON:cjm") Annotation( "Wikipedia:Pulmonary_pleurae") Annotation( "https://github.com/obophenotype/uberon/issues/1231") "The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion).") +AnnotationAssertion( "BTO:0001791") +AnnotationAssertion( "CALOHA:TS-2081") +AnnotationAssertion( "EFO:0001980") +AnnotationAssertion( "EV:0100044") +AnnotationAssertion( "FMA:9583") +AnnotationAssertion( "GAID:360") +AnnotationAssertion( "MA:0000433") +AnnotationAssertion( "MESH:D010994") +AnnotationAssertion( "NCIT:C12469") +AnnotationAssertion( "SCTID:181609007") +AnnotationAssertion( "VHOG:0000394") +AnnotationAssertion( "Wikipedia:Pleura") AnnotationAssertion(rdfs:label "pleura") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30482,6 +41994,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skeletal joint) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "VSAO:0000101") Annotation( "Wikipedia:Joint") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO].") +AnnotationAssertion( "AEO:0000182") +AnnotationAssertion( "BTO:0001686") +AnnotationAssertion( "CALOHA:TS-2023") +AnnotationAssertion( "EFO:0000948") +AnnotationAssertion( "EMAPA:35456") +AnnotationAssertion( "FMA:7490") +AnnotationAssertion( "GAID:102") +AnnotationAssertion( "MA:0000319") +AnnotationAssertion( "MAT:0000188") +AnnotationAssertion( "MESH:D007596") +AnnotationAssertion( "MIAA:0000188") +AnnotationAssertion( "NCIT:C13044") +AnnotationAssertion( "RETIRED_EHDAA2:0003182") +AnnotationAssertion( "SCTID:302536002") +AnnotationAssertion( "TAO:0000367") +AnnotationAssertion( "VHOG:0001276") +AnnotationAssertion( "VSAO:0000101") +AnnotationAssertion( "Wikipedia:Joint") +AnnotationAssertion( "XAO:0000171") +AnnotationAssertion( "ZFA:0001596") +AnnotationAssertion( "galen:Joint") AnnotationAssertion(rdfs:label "skeletal joint") EquivalentClasses( ObjectUnionOf( )) SubClassOf( ) @@ -30491,7 +42025,30 @@ DisjointClasses( (pons) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "VHOG:0001176") "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum.") +AnnotationAssertion( "BAMS:PONS") +AnnotationAssertion( "BAMS:Pons") +AnnotationAssertion( "BIRNLEX:733") +AnnotationAssertion( "BM:Pons") +AnnotationAssertion( "BTO:0001101") +AnnotationAssertion( "CALOHA:TS-0813") +AnnotationAssertion( "DHBA:10661") +AnnotationAssertion( "EFO:0001394") +AnnotationAssertion( "EHDAA2:0004394") +AnnotationAssertion( "EMAPA:17563") +AnnotationAssertion( "EV:0100253") +AnnotationAssertion( "FMA:67943") +AnnotationAssertion( "GAID:578") +AnnotationAssertion( "HBA:9131") +AnnotationAssertion( "MA:0000204") +AnnotationAssertion( "MAT:0000115") +AnnotationAssertion( "MBA:771") +AnnotationAssertion( "MESH:D011149") +AnnotationAssertion( "MIAA:0000115") +AnnotationAssertion( "NCIT:C12511") +AnnotationAssertion( "SCTID:279103004") +AnnotationAssertion( "VHOG:0001176") +AnnotationAssertion( "Wikipedia:Pons") AnnotationAssertion(rdfs:label "pons") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30502,7 +42059,30 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (reproductive system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Reproductive_system") "Anatomical system that has as its parts the organs concerned with reproduction.") +AnnotationAssertion( "AAO:0010258") +AnnotationAssertion( "BILA:0000103") +AnnotationAssertion( "BTO:0000081") +AnnotationAssertion( "CALOHA:TS-1318") +AnnotationAssertion( "EFO:0000809") +AnnotationAssertion( "EHDAA2:0001603") +AnnotationAssertion( "EHDAA:5923") +AnnotationAssertion( "EMAPA:17381") +AnnotationAssertion( "EV:0100100") +AnnotationAssertion( "FMA:7160") +AnnotationAssertion( "GAID:363") +AnnotationAssertion( "HAO:0000374") +AnnotationAssertion( "HAO:0000895") +AnnotationAssertion( "MA:0000326") +AnnotationAssertion( "MIAA:0000305") +AnnotationAssertion( "NCIT:C12841") +AnnotationAssertion( "SCTID:278875001") +AnnotationAssertion( "TAO:0000632") +AnnotationAssertion( "VHOG:0000182") +AnnotationAssertion( "WBbt:0005747") +AnnotationAssertion( "Wikipedia:Reproductive_system") +AnnotationAssertion( "XAO:0000142") +AnnotationAssertion( "ZFA:0000632") AnnotationAssertion(rdfs:label "reproductive system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30515,15 +42095,36 @@ DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) # Class: (gonad) +AnnotationAssertion(Annotation( "ISBN:0140512888") Annotation( "Wikipedia:Gonad") Annotation( "ZFA:0000413") Annotation( "ZFIN:curator") "Reproductive organ that produces and releases eggs (ovary) or sperm (testis).") +AnnotationAssertion( "AAO:0000213") +AnnotationAssertion( "BILA:0000123") +AnnotationAssertion( "BSA:0000079") +AnnotationAssertion( "BTO:0000534") +AnnotationAssertion( "EMAPA:17383") +AnnotationAssertion( "FMA:18250") +AnnotationAssertion( "GAID:368") +AnnotationAssertion( "HAO:0000379") +AnnotationAssertion( "MA:0002420") +AnnotationAssertion( "MESH:D006066") +AnnotationAssertion( "NCIT:C12725") +AnnotationAssertion( "SCTID:304623008") +AnnotationAssertion( "TAO:0000413") +AnnotationAssertion( "VHOG:0000397") +AnnotationAssertion( "WBbt:0005175") +AnnotationAssertion( "Wikipedia:Gonad") +AnnotationAssertion( "XAO:0003146") +AnnotationAssertion( "ZFA:0000413") AnnotationAssertion(rdfs:label "gonad") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30533,7 +42134,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ovary) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0001126") Annotation( "Wikipedia:Ovary") "The gonad of a female organism which contains germ cells.") +AnnotationAssertion( "AAO:0000371") +AnnotationAssertion( "BILA:0000125") +AnnotationAssertion( "BSA:0000080") +AnnotationAssertion( "BTO:0000975") +AnnotationAssertion( "CALOHA:TS-0730") +AnnotationAssertion( "EFO:0000973") +AnnotationAssertion( "EHDAA2:0001360") +AnnotationAssertion( "EHDAA:8124") +AnnotationAssertion( "EMAPA:17962") +AnnotationAssertion( "EV:0100111") +AnnotationAssertion( "FMA:7209") +AnnotationAssertion( "GAID:367") +AnnotationAssertion( "MA:0000384") +AnnotationAssertion( "MESH:D010053") +AnnotationAssertion( "MIAA:0000125") +AnnotationAssertion( "NCIT:C12404") +AnnotationAssertion( "SCTID:181464007") +AnnotationAssertion( "TAO:0000403") +AnnotationAssertion( "VHOG:0000251") +AnnotationAssertion( "Wikipedia:Ovary") +AnnotationAssertion( "XAO:0000258") +AnnotationAssertion( "ZFA:0000403") AnnotationAssertion(rdfs:label "ovary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30544,7 +42167,26 @@ DisjointClasses( (skin epidermis) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "http://orcid.org/0000-0002-6601-2165") "The outer epithelial layer of the skin that is superficial to the dermis.") +AnnotationAssertion( "AAO:0000143") +AnnotationAssertion( "BTO:0000404") +AnnotationAssertion( "CALOHA:TS-0283") +AnnotationAssertion( "EFO:0000954") +AnnotationAssertion( "EMAPA:17528") +AnnotationAssertion( "EV:0100153") +AnnotationAssertion( "FMA:70596") +AnnotationAssertion( "GAID:932") +AnnotationAssertion( "MA:0000153") +AnnotationAssertion( "MAT:0000154") +AnnotationAssertion( "MESH:D004817") +AnnotationAssertion( "MIAA:0000154") +AnnotationAssertion( "NCIT:C12708") +AnnotationAssertion( "SCTID:361694003") +AnnotationAssertion( "TAO:0000105") +AnnotationAssertion( "VHOG:0000077") +AnnotationAssertion( "Wikipedia:Epidermis_(skin)") +AnnotationAssertion( "XAO:0000028") +AnnotationAssertion( "ZFA:0000105") AnnotationAssertion(rdfs:label "skin epidermis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30555,7 +42197,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Respiratory_system") Annotation( "http://orcid.org/0000-0002-6601-2165") "Functional system which consists of structures involved in respiration.") +AnnotationAssertion( "AAO:0000541") +AnnotationAssertion( "BTO:0000203") +AnnotationAssertion( "CALOHA:TS-1319") +AnnotationAssertion( "EFO:0000804") +AnnotationAssertion( "EHDAA2:0001604") +AnnotationAssertion( "EHDAA:2203") +AnnotationAssertion( "EMAPA:16727") +AnnotationAssertion( "EV:0100036") +AnnotationAssertion( "FMA:7158") +AnnotationAssertion( "GAID:78") +AnnotationAssertion( "MA:0000327") +AnnotationAssertion( "MAT:0000030") +AnnotationAssertion( "MESH:D012137") +AnnotationAssertion( "MIAA:0000030") +AnnotationAssertion( "NCIT:C12779") +AnnotationAssertion( "SCTID:278197002") +AnnotationAssertion( "TAO:0000272") +AnnotationAssertion( "VHOG:0000202") +AnnotationAssertion( "Wikipedia:Respiratory_system") +AnnotationAssertion( "XAO:0000117") +AnnotationAssertion( "ZFA:0000272") AnnotationAssertion(rdfs:label "respiratory system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30568,15 +42231,20 @@ DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) # Class: (respiratory airway) +AnnotationAssertion(Annotation( "Wikipedia:Trachea") "An airway through which respiratory air passes in organisms.") +AnnotationAssertion( "SCTID:361380005") +AnnotationAssertion( "Wikipedia:Trachea") AnnotationAssertion(rdfs:label "respiratory airway") SubClassOf( ) SubClassOf( ) @@ -30585,7 +42253,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (digestive system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FB:gg") Annotation( "NLM:alimentary+system") Annotation( "Wikipedia:Digestive_system") "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes.") +AnnotationAssertion( "AAO:0000129") +AnnotationAssertion( "BILA:0000082") +AnnotationAssertion( "BTO:0000058") +AnnotationAssertion( "CALOHA:TS-1293") +AnnotationAssertion( "EFO:0000793") +AnnotationAssertion( "FMA:7152") +AnnotationAssertion( "GAID:278") +AnnotationAssertion( "MA:0002431") +AnnotationAssertion( "MAT:0000018") +AnnotationAssertion( "MESH:D004064") +AnnotationAssertion( "MIAA:0000018") +AnnotationAssertion( "SCTID:278859004") +AnnotationAssertion( "TADS:0000170") +AnnotationAssertion( "TAO:0000339") +AnnotationAssertion( "WBbt:0005748") +AnnotationAssertion( "Wikipedia:Digestive_system") +AnnotationAssertion( "XAO:0000125") +AnnotationAssertion( "ZFA:0000339") +AnnotationAssertion( "galen:DigestiveSystem") +AnnotationAssertion( "ncithesaurus:Digestive_System") AnnotationAssertion(rdfs:label "digestive system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30595,16 +42283,59 @@ DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +# Class: (renal system) + +AnnotationAssertion(Annotation( "DOI:10.1371/journal.pone.0099864") Annotation( "GO:0072001") "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products.") +AnnotationAssertion( "AAO:0010257") +AnnotationAssertion( "BILA:0000015") +AnnotationAssertion( "BTO:0001244") +AnnotationAssertion( "BTO:0003092") +AnnotationAssertion( "CALOHA:TS-1323") +AnnotationAssertion( "EFO:0000803") +AnnotationAssertion( "EHDAA2:0001601") +AnnotationAssertion( "EHDAA:5901") +AnnotationAssertion( "EMAPA:17366") +AnnotationAssertion( "EV:0100095") +AnnotationAssertion( "FMA:7159") +AnnotationAssertion( "GAID:391") +AnnotationAssertion( "MA:0000325") +AnnotationAssertion( "MAT:0000027") +AnnotationAssertion( "MESH:D014551") +AnnotationAssertion( "MIAA:0000027") +AnnotationAssertion( "NCIT:C12413") +AnnotationAssertion( "SCTID:362204003") +AnnotationAssertion( "TADS:0000162") +AnnotationAssertion( "TAO:0000163") +AnnotationAssertion( "VHOG:0000723") +AnnotationAssertion( "WBbt:0005736") +AnnotationAssertion( "Wikipedia:Excretory_system") +AnnotationAssertion( "XAO:0000143") +AnnotationAssertion( "ZFA:0000163") +AnnotationAssertion( "galen:UrinaryTract") +AnnotationAssertion(rdfs:comment "EDITOR_NOTE In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here") +AnnotationAssertion(rdfs:label "renal system") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (circulatory system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Circulatory_system") "Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP].") +AnnotationAssertion( "AAO:0000959") +AnnotationAssertion( "CALOHA:TS-2103") +AnnotationAssertion( "VHOG:0001248") +AnnotationAssertion( "Wikipedia:Circulatory_system") AnnotationAssertion(rdfs:label "circulatory system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30613,16 +42344,40 @@ SubClassOf( ObjectSomeValuesFrom( DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) # Class: (adipose tissue) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:A10.165.114") Annotation( "MGI:cwg") Annotation( "MP:0000003") Annotation( "Wikipedia:Adipose_tissue") Annotation( "http://orcid.org/0000-0002-6601-2165") "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue.") +AnnotationAssertion( "AAO:0000001") +AnnotationAssertion( "AEO:000020") +AnnotationAssertion( "BTO:0001487") +AnnotationAssertion( "CALOHA:TS-0013") +AnnotationAssertion( "EFO:0000790") +AnnotationAssertion( "EHDAA2:0003120") +AnnotationAssertion( "EMAPA:35112") +AnnotationAssertion( "EV:0100381") +AnnotationAssertion( "FMA:20110") +AnnotationAssertion( "GAID:920") +AnnotationAssertion( "MA:0000009") +AnnotationAssertion( "MAT:0000015") +AnnotationAssertion( "MESH:D000273") +AnnotationAssertion( "MIAA:0000015") +AnnotationAssertion( "NCIT:C12472") +AnnotationAssertion( "SCTID:55603005") +AnnotationAssertion( "TAO:0002134") +AnnotationAssertion( "VHOG:0001284") +AnnotationAssertion( "Wikipedia:Adipose_tissue") +AnnotationAssertion( "XAO:0003049") +AnnotationAssertion( "ZFA:0005345") +AnnotationAssertion( "galen:FattyTissue") AnnotationAssertion(rdfs:label "adipose tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30631,6 +42386,18 @@ DisjointClasses( (musculature) +AnnotationAssertion(Annotation( "Wikipedia:Muscular_system") Annotation( "https://orcid.org/0000-0002-6601-2165") "A subdivision of the muscular system corresponding to a subdisivision of an organism.") +AnnotationAssertion( "BTO:0000887") +AnnotationAssertion( "EFO:0001949") +AnnotationAssertion( "EMAPA:35577") +AnnotationAssertion( "FMA:32558") +AnnotationAssertion( "MA:0000165") +AnnotationAssertion( "NCIT:C13056") +AnnotationAssertion( "TAO:0000548") +AnnotationAssertion( "VSAO:0005038") +AnnotationAssertion( "WBbt:0005737") +AnnotationAssertion( "Wikipedia:Muscular_system") +AnnotationAssertion( "ZFA:0000548") AnnotationAssertion(rdfs:label "musculature") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30638,7 +42405,32 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nervous system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "BIRNLEX:844") Annotation( "ISBN:0-14-051288-8") Annotation( "ISBN:3110148986") Annotation( "NLM:nervous+system") Annotation( "WB:rynl") Annotation( "Wikipedia:Nervous_system") Annotation( "ZFIN:curator") "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].") +AnnotationAssertion( "AAO:0000324") +AnnotationAssertion( "BILA:0000079") +AnnotationAssertion( "BIRNLEX:844") +AnnotationAssertion( "BTO:0001484") +AnnotationAssertion( "CALOHA:TS-1313") +AnnotationAssertion( "EFO:0000802") +AnnotationAssertion( "EHDAA2:0001246") +AnnotationAssertion( "EHDAA:826") +AnnotationAssertion( "EMAPA:16469") +AnnotationAssertion( "EV:0100162") +AnnotationAssertion( "FMA:7157") +AnnotationAssertion( "GAID:466") +AnnotationAssertion( "MA:0000016") +AnnotationAssertion( "MAT:0000026") +AnnotationAssertion( "MESH:D009420") +AnnotationAssertion( "MIAA:0000026") +AnnotationAssertion( "NCIT:C12755") +AnnotationAssertion( "SCTID:278196006") +AnnotationAssertion( "TAO:0000396") +AnnotationAssertion( "VHOG:0000402") +AnnotationAssertion( "WBbt:0005735") +AnnotationAssertion( "Wikipedia:Nervous_system") +AnnotationAssertion( "XAO:0000177") +AnnotationAssertion( "ZFA:0000396") +AnnotationAssertion( "neuronames:3236") AnnotationAssertion(rdfs:label "nervous system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30649,16 +42441,43 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) # Class: (central nervous system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0021551") Annotation( "http://www.frontiersinzoology.com/content/7/1/29") Annotation( "https://sourceforge.net/p/geneontology/ontology-requests/11422/") "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.") +AnnotationAssertion( "AAO:0000090") +AnnotationAssertion( "BAMS:CNS") +AnnotationAssertion( "BILA:0000080") +AnnotationAssertion( "BIRNLEX:1099") +AnnotationAssertion( "BTO:0000227") +AnnotationAssertion( "CALOHA:TS-0150") +AnnotationAssertion( "EFO:0000908") +AnnotationAssertion( "EHDAA2:0000225") +AnnotationAssertion( "EHDAA:828") +AnnotationAssertion( "EMAPA:16470") +AnnotationAssertion( "EMAPA:16754") +AnnotationAssertion( "EV:0100163") +AnnotationAssertion( "FMA:55675") +AnnotationAssertion( "GAID:570") +AnnotationAssertion( "MA:0000167") +AnnotationAssertion( "MAT:0000457") +AnnotationAssertion( "MESH:D002490") +AnnotationAssertion( "NCIT:C12438") +AnnotationAssertion( "SCTID:278199004") +AnnotationAssertion( "TAO:0000012") +AnnotationAssertion( "VHOG:0000293") +AnnotationAssertion( "Wikipedia:Central_nervous_system") +AnnotationAssertion( "XAO:0000215") +AnnotationAssertion( "ZFA:0000012") +AnnotationAssertion( "neuronames:854") AnnotationAssertion(rdfs:label "central nervous system") SubClassOf( ) SubClassOf( ) @@ -30668,7 +42487,41 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nerve) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FBbt:00005105") Annotation( "http://orcid.org/0000-0002-6601-2165") "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures.") +AnnotationAssertion( "AAO:0011070") +AnnotationAssertion( "AEO:0000137") +AnnotationAssertion( "BAMS:n") +AnnotationAssertion( "BIRNLEX:1615") +AnnotationAssertion( "BSA:0000098") +AnnotationAssertion( "BTO:0000925") +AnnotationAssertion( "BTO:0001027") +AnnotationAssertion( "CALOHA:TS-0772") +AnnotationAssertion( "EHDAA2:0003137") +AnnotationAssertion( "EHDAA:2851") +AnnotationAssertion( "EHDAA:3776") +AnnotationAssertion( "EHDAA:4657") +AnnotationAssertion( "EMAPA:32808") +AnnotationAssertion( "EMAPA:32815") +AnnotationAssertion( "EV:0100371") +AnnotationAssertion( "FMA:65132") +AnnotationAssertion( "FMA:65239") +AnnotationAssertion( "GAID:747") +AnnotationAssertion( "GAID:758") +AnnotationAssertion( "MA:0000217") +AnnotationAssertion( "MA:0000228") +AnnotationAssertion( "MESH:D010525") +AnnotationAssertion( "NCIT:C12466") +AnnotationAssertion( "NCIT:C12768") +AnnotationAssertion( "NLX:147826") +AnnotationAssertion( "SCTID:244457007") +AnnotationAssertion( "SCTID:256864008") +AnnotationAssertion( "TAO:0007009") +AnnotationAssertion( "VHOG:0000901") +AnnotationAssertion( "Wikipedia:Nervous_system") +AnnotationAssertion( "XAO:0000204") +AnnotationAssertion( "XAO:0003047") +AnnotationAssertion( "ZFA:0007009") +AnnotationAssertion( "galen:Nerve") AnnotationAssertion(rdfs:label "nerve") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30676,12 +42529,34 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sensory nerve) +AnnotationAssertion(Annotation( "UBERON:cjm") Annotation( "Wikipedia:Sensory_nerve") "A nerve that transmits from sensory receptors on the surface of the body to the central nervous system.") +AnnotationAssertion( "AEO:0000201") +AnnotationAssertion( "EHDAA2:0003200") +AnnotationAssertion( "FMA:5868") +AnnotationAssertion( "Wikipedia:Sensory_nerve") AnnotationAssertion(rdfs:label "sensory nerve") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (sensory system) +AnnotationAssertion(Annotation( "Wikipedia:Sensory_system") "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information.") +AnnotationAssertion( "AAO:0000555") +AnnotationAssertion( "BAMS:SEN") +AnnotationAssertion( "BILA:0000099") +AnnotationAssertion( "EFO:0000805") +AnnotationAssertion( "EHDAA2:0003094") +AnnotationAssertion( "EMAPA:16192") +AnnotationAssertion( "FMA:75259") +AnnotationAssertion( "MA:0002442") +AnnotationAssertion( "MAT:0000031") +AnnotationAssertion( "MIAA:0000031") +AnnotationAssertion( "NLXANAT:090816") +AnnotationAssertion( "TAO:0000282") +AnnotationAssertion( "VHOG:0001674") +AnnotationAssertion( "Wikipedia:Sensory_system") +AnnotationAssertion( "XAO:0003194") +AnnotationAssertion( "ZFA:0000282") AnnotationAssertion(rdfs:label "sensory system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30690,6 +42565,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (yolk sac) +AnnotationAssertion(Annotation( "Wikipedia:Yolk_sac") "A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP].") +AnnotationAssertion( "BTO:0001471") +AnnotationAssertion( "CALOHA:TS-1130") +AnnotationAssertion( "EFO:0003078") +AnnotationAssertion( "EHDAA2:0002212") +AnnotationAssertion( "EHDAA:164") +AnnotationAssertion( "EMAPA:16085") +AnnotationAssertion( "FMA:87180") +AnnotationAssertion( "GAID:1301") +AnnotationAssertion( "MESH:D015017") +AnnotationAssertion( "NCIT:C14128") +AnnotationAssertion( "SCTID:362845002") +AnnotationAssertion( "VHOG:0000830") +AnnotationAssertion( "Wikipedia:Yolk_sac") AnnotationAssertion(rdfs:label "yolk sac") SubClassOf( ) SubClassOf( ) @@ -30699,11 +42588,48 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (foregut) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Anterior subdivision of a digestive tract.") +AnnotationAssertion( "AAO:0011042") +AnnotationAssertion( "BILA:0000085") +AnnotationAssertion( "BTO:0000507") +AnnotationAssertion( "EHDAA2:0000557") +AnnotationAssertion( "EHDAA:520") +AnnotationAssertion( "EMAPA:16548") +AnnotationAssertion( "FMA:45616") +AnnotationAssertion( "MA:0001526") +AnnotationAssertion( "NCIT:C34180") +AnnotationAssertion( "SCTID:361409009") +AnnotationAssertion( "TGMA:0001014") +AnnotationAssertion( "VHOG:0000285") +AnnotationAssertion( "Wikipedia:Foregut") +AnnotationAssertion( "XAO:0000232") AnnotationAssertion(rdfs:label "foregut") SubClassOf( ) # Class: (chordate pharynx) +AnnotationAssertion(Annotation( "http://www.feedexp.org") "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED].") +AnnotationAssertion( "AAO:0000967") +AnnotationAssertion( "BTO:0001049") +AnnotationAssertion( "CALOHA:TS-0785") +AnnotationAssertion( "EFO:0000836") +AnnotationAssertion( "EHDAA2:0001458") +AnnotationAssertion( "EHDAA:2947") +AnnotationAssertion( "EMAPA:16706") +AnnotationAssertion( "EV:0100065") +AnnotationAssertion( "FMA:46688") +AnnotationAssertion( "GAID:155") +AnnotationAssertion( "MA:0000432") +AnnotationAssertion( "MESH:D010614") +AnnotationAssertion( "NCIT:C12425") +AnnotationAssertion( "SCTID:181211006") +AnnotationAssertion( "TAO:0000056") +AnnotationAssertion( "VHOG:0000462") +AnnotationAssertion( "Wikipedia:Pharynx") +AnnotationAssertion( "XAO:0003227") +AnnotationAssertion( "ZFA:0000056") +AnnotationAssertion( "galen:Pharynx") +AnnotationAssertion(rdfs:comment "Consider generalizing to deuterostome pharynx") AnnotationAssertion(rdfs:label "chordate pharynx") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30712,7 +42638,30 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (esophagus) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Esophagus") Annotation( "http://www.rivm.nl/interspeciesinfo/inter/oesophagus/") "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).") +AnnotationAssertion( "AAO:0000145") +AnnotationAssertion( "ANISEED:1235301") +AnnotationAssertion( "BTO:0000959") +AnnotationAssertion( "CALOHA:TS-0700") +AnnotationAssertion( "EFO:0000835") +AnnotationAssertion( "EHDAA2:0001285") +AnnotationAssertion( "EHDAA:2937") +AnnotationAssertion( "EMAPA:16833") +AnnotationAssertion( "EV:0100069") +AnnotationAssertion( "FMA:7131") +AnnotationAssertion( "GAID:291") +AnnotationAssertion( "MA:0000352") +AnnotationAssertion( "MAT:0000048") +AnnotationAssertion( "MESH:D004947") +AnnotationAssertion( "MIAA:0000048") +AnnotationAssertion( "NCIT:C12389") +AnnotationAssertion( "SCTID:181245004") +AnnotationAssertion( "TAO:0000204") +AnnotationAssertion( "VHOG:0000450") +AnnotationAssertion( "Wikipedia:Esophagus") +AnnotationAssertion( "XAO:0000127") +AnnotationAssertion( "ZFA:0000204") +AnnotationAssertion( "galen:Esophagus") AnnotationAssertion(rdfs:label "esophagus") SubClassOf( ) SubClassOf( ) @@ -30721,14 +42670,88 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (midgut) + +AnnotationAssertion(Annotation( "GO:0007494") Annotation( "Wikipedia:Midgut") "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO].") +AnnotationAssertion( "BILA:0000086") +AnnotationAssertion( "BTO:0000863") +AnnotationAssertion( "EFO:0001950") +AnnotationAssertion( "EHDAA2:0001185") +AnnotationAssertion( "EHDAA:983") +AnnotationAssertion( "EMAPA:16255") +AnnotationAssertion( "FMA:45617") +AnnotationAssertion( "MA:0001564") +AnnotationAssertion( "NCIT:C34210") +AnnotationAssertion( "SCTID:361410004") +AnnotationAssertion( "TGMA:0001036") +AnnotationAssertion( "VHOG:0000290") +AnnotationAssertion( "Wikipedia:Midgut") +AnnotationAssertion( "XAO:0000103") +AnnotationAssertion(rdfs:label "midgut") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (hindgut) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The caudalmost subdivision of a digestive tract.") +AnnotationAssertion( "AAO:0011052") +AnnotationAssertion( "BILA:0000087") +AnnotationAssertion( "BTO:0000510") +AnnotationAssertion( "EHDAA2:0000779") +AnnotationAssertion( "EHDAA:975") +AnnotationAssertion( "EMAPA:16715") +AnnotationAssertion( "FMA:45618") +AnnotationAssertion( "MA:0001527") +AnnotationAssertion( "NCIT:C34188") +AnnotationAssertion( "SCTID:362856002") +AnnotationAssertion( "TGMA:0001020") +AnnotationAssertion( "VHOG:0000459") +AnnotationAssertion( "Wikipedia:Hindgut") +AnnotationAssertion( "XAO:0000104") +AnnotationAssertion(rdfs:label "hindgut") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (primordium) +AnnotationAssertion(Annotation( "BTO:0001886") Annotation( "FB:DJS") Annotation( "FB:FBrf0089570") Annotation( "http://flybase.org/reports/FBrf0178740.html") "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)].") +AnnotationAssertion( "AEO:0000171") +AnnotationAssertion( "BTO:0001886") +AnnotationAssertion( "EFO:0001652") +AnnotationAssertion( "EHDAA2:0003171") +AnnotationAssertion( "FMA:86589") +AnnotationAssertion( "MAT:0000482") +AnnotationAssertion( "NCIT:C34275") +AnnotationAssertion( "Wikipedia:Primordium") +AnnotationAssertion( "XAO:0003043") AnnotationAssertion(rdfs:label "primordium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (neural tube) +AnnotationAssertion(Annotation( "Wikipedia:Neural_tube") "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted].") +AnnotationAssertion( "AAO:0010617") +AnnotationAssertion( "BTO:0001057") +AnnotationAssertion( "CALOHA:TS-2371") +AnnotationAssertion( "DHBA:10154") +AnnotationAssertion( "EHDAA2:0001254") +AnnotationAssertion( "EHDAA:2869") +AnnotationAssertion( "EHDAA:908") +AnnotationAssertion( "EMAPA:16164") +AnnotationAssertion( "EMAPA:16757") +AnnotationAssertion( "FMA:293882") +AnnotationAssertion( "MAT:0000069") +AnnotationAssertion( "MIAA:0000069") +AnnotationAssertion( "NCIT:C34226") +AnnotationAssertion( "SCTID:362852000") +AnnotationAssertion( "TAO:0001135") +AnnotationAssertion( "VHOG:0000307") +AnnotationAssertion( "Wikipedia:Neural_tube") +AnnotationAssertion( "XAO:0003204") +AnnotationAssertion( "ZFA:0001135") +AnnotationAssertion( "neuronames:1365") AnnotationAssertion(rdfs:label "neural tube") SubClassOf( ) SubClassOf( ) @@ -30736,15 +42759,93 @@ SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (rectum) + +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0000492") Annotation( "http://orcid.org/0000-0002-6601-2165") "The terminal portion of the intestinal tube, terminating with the anus.") +AnnotationAssertion( "AAO:0010401") +AnnotationAssertion( "BTO:0001158") +AnnotationAssertion( "CALOHA:TS-1180") +AnnotationAssertion( "EFO:0000848") +AnnotationAssertion( "EHDAA2:0001592") +AnnotationAssertion( "EHDAA:5836") +AnnotationAssertion( "EMAPA:17896") +AnnotationAssertion( "EV:0100081") +AnnotationAssertion( "FMA:14544") +AnnotationAssertion( "GAID:311") +AnnotationAssertion( "MA:0000336") +AnnotationAssertion( "MAT:0000050") +AnnotationAssertion( "MESH:D012007") +AnnotationAssertion( "MIAA:0000050") +AnnotationAssertion( "NCIT:C12390") +AnnotationAssertion( "SCTID:181261002") +AnnotationAssertion( "VHOG:0001751") +AnnotationAssertion( "Wikipedia:Rectum") +AnnotationAssertion( "XAO:0000238") +AnnotationAssertion( "galen:Rectum") +AnnotationAssertion(rdfs:label "rectum") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (anatomical entity) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FMA:62955") Annotation( "http://orcid.org/0000-0001-9114-8737") "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.") +AnnotationAssertion( "AAO:0010841") +AnnotationAssertion( "AEO:0000000") +AnnotationAssertion( "BFO:0000004") +AnnotationAssertion( "BILA:0000000") +AnnotationAssertion( "BIRNLEX:6") +AnnotationAssertion( "CARO:0000000") +AnnotationAssertion( "EHDAA2:0002229") +AnnotationAssertion( "FMA:62955") +AnnotationAssertion( "HAO:0000000") +AnnotationAssertion( "MA:0000001") +AnnotationAssertion( "NCIT:C12219") +AnnotationAssertion( "TAO:0100000") +AnnotationAssertion( "TGMA:0001822") +AnnotationAssertion( "WBbt:0000100") +AnnotationAssertion( "XAO:0000000") +AnnotationAssertion( "ZFA:0100000") AnnotationAssertion(rdfs:label "anatomical entity") +# Class: (ventral pancreatic duct) + +AnnotationAssertion(Annotation( "Wikipedia:Pancreatic_duct") "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla.") +AnnotationAssertion( "BTO:0002362") +AnnotationAssertion( "EHDAA2:0001396") +AnnotationAssertion( "EHDAA:6905") +AnnotationAssertion( "EMAPA:17510") +AnnotationAssertion( "FMA:16003") +AnnotationAssertion( "GAID:337") +AnnotationAssertion( "MA:0000126") +AnnotationAssertion( "MESH:D010183") +AnnotationAssertion( "NCIT:C12272") +AnnotationAssertion( "RETIRED_EHDAA2:0002177") +AnnotationAssertion( "SCTID:245385001") +AnnotationAssertion( "VHOG:0000256") +AnnotationAssertion( "Wikipedia:Pancreatic_duct") +AnnotationAssertion(rdfs:comment "EDITOR_NOTE in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue") +AnnotationAssertion(rdfs:label "ventral pancreatic duct") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (skin of back) +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a back [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36392") +AnnotationAssertion( "FMA:10462") +AnnotationAssertion( "FMA:22985") +AnnotationAssertion( "MA:0000498") +AnnotationAssertion( "SCTID:181492002") +AnnotationAssertion(rdfs:comment "EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region") AnnotationAssertion(rdfs:label "skin of back") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30752,7 +42853,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (external carotid artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MGI:anna") "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP].") +AnnotationAssertion( "AAO:0010218") +AnnotationAssertion( "AAO:0010416") +AnnotationAssertion( "BTO:0004696") +AnnotationAssertion( "EFO:0001953") +AnnotationAssertion( "EHDAA2:0000461") +AnnotationAssertion( "EMAPA:18611") +AnnotationAssertion( "FMA:10635") +AnnotationAssertion( "GAID:480") +AnnotationAssertion( "MA:0001929") +AnnotationAssertion( "MESH:D002342") +AnnotationAssertion( "NCIT:C32551") +AnnotationAssertion( "SCTID:362044002") +AnnotationAssertion( "VHOG:0000265") +AnnotationAssertion( "Wikipedia:External_carotid_artery") +AnnotationAssertion( "XAO:0000345") AnnotationAssertion(rdfs:label "external carotid artery") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -30761,7 +42877,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (superficial cervical artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Superficial_part_of_transverse_cervical_artery") "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery.") +AnnotationAssertion( "FMA:10665") +AnnotationAssertion( "MA:0002052") +AnnotationAssertion( "NCIT:C53005") +AnnotationAssertion( "SCTID:161746006") +AnnotationAssertion( "Wikipedia:Superficial_part_of_transverse_cervical_artery") +AnnotationAssertion(rdfs:comment "The transverse cervical artery splits into two branches, a superficial one and a deep one[WP]") AnnotationAssertion(rdfs:label "superficial cervical artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30770,15 +42892,56 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (inferior vena cava) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Inferior_vena_cava") Annotation( "http://orcid.org/0000-0002-6601-2165") "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart.") +AnnotationAssertion( "AAO:0011083") +AnnotationAssertion( "BTO:0002682") +AnnotationAssertion( "EHDAA2:0000611") +AnnotationAssertion( "EMAPA:18416") +AnnotationAssertion( "FMA:10951") +AnnotationAssertion( "GAID:548") +AnnotationAssertion( "MA:0000480") +AnnotationAssertion( "MESH:D014682") +AnnotationAssertion( "NCIT:C12815") +AnnotationAssertion( "SCTID:181369003") +AnnotationAssertion( "VHOG:0001194") +AnnotationAssertion( "Wikipedia:Inferior_vena_cava") +AnnotationAssertion( "XAO:0000388") +AnnotationAssertion( "galen:InferiorVenaCava") AnnotationAssertion(rdfs:label "inferior vena cava") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (ileocecal junction) + +AnnotationAssertion(Annotation( "http://www.medilexicon.com/medicaldictionary.php?t=46539") "A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice.") +AnnotationAssertion( "FMA:11338") +AnnotationAssertion( "MA:0000332") +AnnotationAssertion( "SCTID:264021000") +AnnotationAssertion(rdfs:label "ileocecal junction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (pericardial cavity) +AnnotationAssertion(Annotation( "Wikipedia:Pericardium") "A potential space between the visceral and parietal layers of the pericardium.") +AnnotationAssertion( "BSA:0000091") +AnnotationAssertion( "EHDAA2:0001434") +AnnotationAssertion( "EMAPA:16131") +AnnotationAssertion( "EMAPA:16132") +AnnotationAssertion( "FMA:11350") +AnnotationAssertion( "MA:0000053") +AnnotationAssertion( "NCIT:C38662") +AnnotationAssertion( "SCTID:362027001") +AnnotationAssertion( "TAO:0002220") +AnnotationAssertion( "VHOG:0000556") +AnnotationAssertion( "Wikipedia:Pericardial_cavity") +AnnotationAssertion( "ZFA:0001655") +AnnotationAssertion( "galen:PericardialSpace") AnnotationAssertion(rdfs:label "pericardial cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30791,6 +42954,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endocardium of ventricle) +AnnotationAssertion(Annotation( "ZFIN:curator") "Endocardium that is part of the cardiac ventricle.") +AnnotationAssertion( "EMAPA:32747") +AnnotationAssertion( "FMA:12148") +AnnotationAssertion( "MA:0000079") +AnnotationAssertion( "SCTID:192172004") +AnnotationAssertion( "TAO:0002247") +AnnotationAssertion( "VHOG:0000607") +AnnotationAssertion( "ZFA:0001615") AnnotationAssertion(rdfs:label "endocardium of ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30801,6 +42972,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epicardium of ventricle) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An epicardial layer that lines a cardiac ventricle.") +AnnotationAssertion( "FMA:12150") +AnnotationAssertion( "TAO:0005058") +AnnotationAssertion( "ZFA:0005058") AnnotationAssertion(rdfs:label "epicardium of ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30808,6 +42983,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (myocardium of ventricle) +AnnotationAssertion(Annotation( "ZFIN:curator") "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer.") +AnnotationAssertion( "EFO:0003088") +AnnotationAssertion( "EMAPA:32748") +AnnotationAssertion( "FMA:12151") +AnnotationAssertion( "MA:0000082") +AnnotationAssertion( "SCTID:192084000") +AnnotationAssertion( "TAO:0005061") +AnnotationAssertion( "VHOG:0000604") +AnnotationAssertion( "ZFA:0005061") AnnotationAssertion(rdfs:label "myocardium of ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30816,6 +43000,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin of head) +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a head [Automatically generated definition].") +AnnotationAssertion( "FMA:12166") +AnnotationAssertion( "FMA:24756") +AnnotationAssertion( "MA:0000582") +AnnotationAssertion( "NCIT:C52757") +AnnotationAssertion( "SCTID:181484006") +AnnotationAssertion(rdfs:comment "EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region") AnnotationAssertion(rdfs:label "skin of head") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30823,6 +43014,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin of trunk) +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a trunk [Automatically generated definition].") +AnnotationAssertion( "FMA:12167") +AnnotationAssertion( "FMA:23093") +AnnotationAssertion( "MA:0000517") +AnnotationAssertion( "NCIT:C12295") +AnnotationAssertion( "SCTID:181489001") +AnnotationAssertion(rdfs:comment "EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region") AnnotationAssertion(rdfs:label "skin of trunk") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30830,6 +43028,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pleural fluid) +AnnotationAssertion(Annotation( "FMA:12273") "Transudate contained in the pleural cavity.") +AnnotationAssertion( "BTO:0003080") +AnnotationAssertion( "FMA:12273") +AnnotationAssertion( "MA:0002532") +AnnotationAssertion( "MAT:0000500") +AnnotationAssertion( "Wikipedia:Pleural_fluid") +AnnotationAssertion( "ncithesaurus:Pleural_Fluid") AnnotationAssertion(rdfs:label "pleural fluid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30837,6 +43042,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (synovial fluid) +AnnotationAssertion(Annotation( "https://www.ncbi.nlm.nih.gov/books/NBK274/") "Joint fluid is a transudate of plasma that is actively secreted by synovial cells.") +AnnotationAssertion( "BTO:0001339") +AnnotationAssertion( "CALOHA:TS-0996") +AnnotationAssertion( "ENVO:02000039") +AnnotationAssertion( "FMA:12277") +AnnotationAssertion( "GAID:265") +AnnotationAssertion( "MA:0002544") +AnnotationAssertion( "MESH:D013582") +AnnotationAssertion( "NCIT:C33718") +AnnotationAssertion( "TAO:0005154") +AnnotationAssertion( "Wikipedia:Synovial_fluid") +AnnotationAssertion( "ZFA:0005154") +AnnotationAssertion( "galen:SynovialFluid") AnnotationAssertion(rdfs:label "synovial fluid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30845,8 +43063,70 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (vertebral bone 1) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The first vertebral bone in the vertebral column.") +AnnotationAssertion( "AAO:0000709") +AnnotationAssertion( "EHDAA:10606") +AnnotationAssertion( "EMAPA:19431") +AnnotationAssertion( "FMA:12519") +AnnotationAssertion( "GAID:236") +AnnotationAssertion( "MA:0001421") +AnnotationAssertion( "MESH:D001270") +AnnotationAssertion( "NCIT:C32239") +AnnotationAssertion( "SCTID:181818007") +AnnotationAssertion( "TAO:0001167") +AnnotationAssertion( "Wikipedia:Atlas_(anatomy)") +AnnotationAssertion( "ZFA:0001167") +AnnotationAssertion(rdfs:label "vertebral bone 1") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (vertebral bone 2) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The second vertebral bone in the vertebral column.") +AnnotationAssertion( "EHDAA:10608") +AnnotationAssertion( "EMAPA:19432") +AnnotationAssertion( "FMA:12520") +AnnotationAssertion( "GAID:237") +AnnotationAssertion( "MA:0001422") +AnnotationAssertion( "MESH:D001368") +AnnotationAssertion( "NCIT:C32240") +AnnotationAssertion( "SCTID:181819004") +AnnotationAssertion( "TAO:0001168") +AnnotationAssertion( "Wikipedia:Axis_(anatomy)") +AnnotationAssertion( "ZFA:0001168") +AnnotationAssertion(rdfs:label "vertebral bone 2") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (caudal vertebra) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx).") +AnnotationAssertion( "EMAPA:18374") +AnnotationAssertion( "FMA:12527") +AnnotationAssertion( "MA:0000310") +AnnotationAssertion( "MA:0001420") +AnnotationAssertion( "NCIT:C32334") +AnnotationAssertion( "SCTID:361774004") +AnnotationAssertion( "TAO:0000326") +AnnotationAssertion( "Wikipedia:Caudal_vertebra") +AnnotationAssertion( "XAO:0003079") +AnnotationAssertion( "ZFA:0000326") +AnnotationAssertion( "galen:CoccygealVertebra") +AnnotationAssertion(rdfs:comment "Taxon notes In zebrafish, Vertebra bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae") +AnnotationAssertion(rdfs:label "caudal vertebra") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (wall of esophagus) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical wall that is part of a esophagus [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35326") +AnnotationAssertion( "FMA:12611") +AnnotationAssertion( "MA:0002691") AnnotationAssertion(rdfs:label "wall of esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30854,6 +43134,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (diaphragm) +AnnotationAssertion(Annotation( "MP:0002279") "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control.") +AnnotationAssertion( "BTO:0000341") +AnnotationAssertion( "CALOHA:TS-0198") +AnnotationAssertion( "EFO:0000937") +AnnotationAssertion( "EHDAA2:0003495") +AnnotationAssertion( "EMAPA:17701") +AnnotationAssertion( "EV:0100376") +AnnotationAssertion( "FMA:13295") +AnnotationAssertion( "GAID:158") +AnnotationAssertion( "MA:0001904") +AnnotationAssertion( "MAT:0000502") +AnnotationAssertion( "MESH:D003964") +AnnotationAssertion( "NCIT:C12702") +AnnotationAssertion( "SCTID:181614006") +AnnotationAssertion( "VHOG:0000713") +AnnotationAssertion( "Wikipedia:Thoracid_diaphragm") AnnotationAssertion(rdfs:label "diaphragm") SubClassOf( ) SubClassOf( ) @@ -30861,8 +43157,103 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (lobe of liver) + +AnnotationAssertion(Annotation( "Wikipedia:Liver#Lobes") "Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe.") +AnnotationAssertion( "EMAPA:18306") +AnnotationAssertion( "FMA:13361") +AnnotationAssertion( "MA:0000360") +AnnotationAssertion( "NCIT:C49579") +AnnotationAssertion( "SCTID:245378000") +AnnotationAssertion( "Wikipedia:Liver#Lobes") +AnnotationAssertion(rdfs:label "lobe of liver") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (right lobe of liver) + +AnnotationAssertion(Annotation( "Wikipedia:Right_lobe_of_liver") "The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted].") +AnnotationAssertion( "EHDAA2:0001008") +AnnotationAssertion( "EHDAA:4001") +AnnotationAssertion( "EMAPA:18311") +AnnotationAssertion( "FMA:13362") +AnnotationAssertion( "MA:0000363") +AnnotationAssertion( "NCIT:C33481") +AnnotationAssertion( "SCTID:362182008") +AnnotationAssertion( "TAO:0005173") +AnnotationAssertion( "VHOG:0001424") +AnnotationAssertion( "Wikipedia:Right_lobe_of_liver") +AnnotationAssertion( "ZFA:0005173") +AnnotationAssertion(rdfs:label "right lobe of liver") +SubClassOf( ) + +# Class: (left lobe of liver) + +AnnotationAssertion(Annotation( "Wikipedia:Left_lobe_of_liver") "The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted].") +AnnotationAssertion( "EHDAA2:0001000") +AnnotationAssertion( "EHDAA:3995") +AnnotationAssertion( "EMAPA:18307") +AnnotationAssertion( "FMA:13363") +AnnotationAssertion( "MA:0000361") +AnnotationAssertion( "NCIT:C32965") +AnnotationAssertion( "SCTID:362183003") +AnnotationAssertion( "TAO:0005172") +AnnotationAssertion( "VHOG:0001423") +AnnotationAssertion( "Wikipedia:Left_lobe_of_liver") +AnnotationAssertion( "ZFA:0005172") +AnnotationAssertion(rdfs:label "left lobe of liver") +SubClassOf( ) + +# Class: (vertebral column) + +AnnotationAssertion(Annotation( "VSAO:0000185") Annotation( "https://orcid.org/0000-0002-6601-2165") Annotation( "https://sourceforge.net/tracker/?func=detail&aid=3530322&group_id=76834&atid=2257941") "Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO].") +AnnotationAssertion( "AAO:0000699") +AnnotationAssertion( "AAO:0000734") +AnnotationAssertion( "BTO:0000818") +AnnotationAssertion( "EFO:0001369") +AnnotationAssertion( "EHDA:10119") +AnnotationAssertion( "EMAPA:35919") +AnnotationAssertion( "FMA:13478") +AnnotationAssertion( "GAID:106") +AnnotationAssertion( "MA:0002416") +AnnotationAssertion( "MESH:D013131") +AnnotationAssertion( "NCIT:C12998") +AnnotationAssertion( "NCIT:C33588") +AnnotationAssertion( "NIF_Subcellular:sao1145756102") +AnnotationAssertion( "SCTID:44300000") +AnnotationAssertion( "TAO:0001559") +AnnotationAssertion( "VHOG:0001142") +AnnotationAssertion( "VSAO:0000185") +AnnotationAssertion( "Wikipedia:Vertebral_column") +AnnotationAssertion( "XAO:0003074") +AnnotationAssertion( "ZFA:0001559") +AnnotationAssertion( "galen:SpinalColumn") +AnnotationAssertion(rdfs:label "vertebral column") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (cardiac muscle tissue) +AnnotationAssertion(Annotation( "ZFA:0005280") "Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified].") +AnnotationAssertion( "AAO:0010245") +AnnotationAssertion( "AEO:0000142") +AnnotationAssertion( "BILA:0000134") +AnnotationAssertion( "BTO:0000199") +AnnotationAssertion( "CALOHA:TS-0440") +AnnotationAssertion( "EHDAA2:0003142") +AnnotationAssertion( "EMAPA:32688") +AnnotationAssertion( "FMA:14068") +AnnotationAssertion( "TAO:0005280") +AnnotationAssertion( "Wikipedia:Cardiac_muscle") +AnnotationAssertion( "ZFA:0005280") +AnnotationAssertion( "galen:CardiacMuscle") +AnnotationAssertion( "galen:CardiacMuscleTissue") +AnnotationAssertion( "ncithesaurus:Heart_Muscle") AnnotationAssertion(rdfs:label "cardiac muscle tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30873,6 +43264,13 @@ DisjointClasses( (skeletal muscle tissue) +AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/issues/324") "Muscle tissue that consists primarily of skeletal muscle fibers.") +AnnotationAssertion( "EMAPA:32716") +AnnotationAssertion( "FMA:14069") +AnnotationAssertion( "MA:0002439") +AnnotationAssertion( "NCIT:C13050") +AnnotationAssertion( "SCTID:426215008") +AnnotationAssertion( "Wikipedia:Skeletal_striated_muscle") AnnotationAssertion(rdfs:label "skeletal muscle tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30882,6 +43280,30 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (smooth muscle tissue) +AnnotationAssertion(Annotation( "GO:0006939") Annotation( "Wikipedia:Smooth_muscle_tissue") "Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO].") +AnnotationAssertion( "AAO:0010244") +AnnotationAssertion( "AEO:0000141") +AnnotationAssertion( "BTO:0001260") +AnnotationAssertion( "CALOHA:TS-0943") +AnnotationAssertion( "EFO:0000889") +AnnotationAssertion( "EHDAA2:0003141") +AnnotationAssertion( "EMAPA:32717") +AnnotationAssertion( "EV:0100378") +AnnotationAssertion( "FMA:14070") +AnnotationAssertion( "GAID:167") +AnnotationAssertion( "MA:0000166") +AnnotationAssertion( "MAT:0000303") +AnnotationAssertion( "MESH:D009130") +AnnotationAssertion( "MIAA:0000303") +AnnotationAssertion( "NCIT:C12437") +AnnotationAssertion( "TAO:0005274") +AnnotationAssertion( "VHOG:0001246") +AnnotationAssertion( "WBbt:0005781") +AnnotationAssertion( "Wikipedia:Smooth_muscle_tissue") +AnnotationAssertion( "XAO:0000175") +AnnotationAssertion( "ZFA:0005274") +AnnotationAssertion( "galen:SmoothMuscle") +AnnotationAssertion( "galen:SmoothMuscleTissue") AnnotationAssertion(rdfs:label "smooth muscle tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30892,6 +43314,23 @@ DisjointClasses( (mesothelium) +AnnotationAssertion(Annotation( "FMA:14074") Annotation( "Wikipedia:Mesothelium") "Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri).") +AnnotationAssertion( "AEO:0000111") +AnnotationAssertion( "BTO:0002422") +AnnotationAssertion( "CALOHA:TS-1183") +AnnotationAssertion( "EHDAA2_RETIRED:0003111") +AnnotationAssertion( "EHDAA:2331") +AnnotationAssertion( "EHDAA:2349") +AnnotationAssertion( "EHDAA:295") +AnnotationAssertion( "EHDAA:6073") +AnnotationAssertion( "EHDAA:640") +AnnotationAssertion( "EHDAA:646") +AnnotationAssertion( "EMAPA:32856") +AnnotationAssertion( "FMA:14074") +AnnotationAssertion( "MA:0000565") +AnnotationAssertion( "NCIT:C33105") +AnnotationAssertion( "SCTID:361918002") +AnnotationAssertion( "Wikipedia:Mesothelium") AnnotationAssertion(rdfs:label "mesothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30901,12 +43340,76 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dorsum) +AnnotationAssertion(Annotation( "BSPO:0000063") Annotation( "UBERONREF:0000006") Annotation( "Wikipedia:Dorsum_(anatomy)") "A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column..") +AnnotationAssertion( "BTO:0001713") +AnnotationAssertion( "CALOHA:TS-2223") +AnnotationAssertion( "EFO:0001405") +AnnotationAssertion( "FMA:14181") +AnnotationAssertion( "GAID:30") +AnnotationAssertion( "MESH:D001415") +AnnotationAssertion( "NCIT:C13062") +AnnotationAssertion( "SCTID:123961009") +AnnotationAssertion( "Wikipedia:Dorsum_(anatomy)") +AnnotationAssertion( "galen:Back") AnnotationAssertion(rdfs:label "dorsum") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (superior mesenteric vein) + +AnnotationAssertion(Annotation( "Wikipedia:Superior_mesenteric_vein") "In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted].") +AnnotationAssertion( "BTO:0002783") +AnnotationAssertion( "EHDAA2:0001951") +AnnotationAssertion( "EHDAA:5414") +AnnotationAssertion( "EMAPA:18643") +AnnotationAssertion( "FMA:14332") +AnnotationAssertion( "MA:0002179") +AnnotationAssertion( "NCIT:C33687") +AnnotationAssertion( "SCTID:278031001") +AnnotationAssertion( "VHOG:0000552") +AnnotationAssertion( "Wikipedia:Superior_mesenteric_vein") +AnnotationAssertion(rdfs:label "superior mesenteric vein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (hepatic vein) + +AnnotationAssertion(Annotation( "Wikipedia:Hepatic_vein") Annotation( "ZFA:0000670") Annotation( "https://sourceforge.net/tracker/?func=detail&aid=3565355&group_id=76834&atid=1205376") "Vein that carries blood away from the liver[ZFA].") +AnnotationAssertion( "AAO:0010216") +AnnotationAssertion( "EMAPA:19221") +AnnotationAssertion( "FMA:14337") +AnnotationAssertion( "GAID:534") +AnnotationAssertion( "MA:0003015") +AnnotationAssertion( "MESH:D006503") +AnnotationAssertion( "NCIT:C32736") +AnnotationAssertion( "SCTID:278191001") +AnnotationAssertion( "TAO:0000670") +AnnotationAssertion( "Wikipedia:Hepatic_vein") +AnnotationAssertion( "XAO:0000387") +AnnotationAssertion( "ZFA:0000670") +AnnotationAssertion( "galen:HepaticVein") +AnnotationAssertion(rdfs:label "hepatic vein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +DisjointClasses( ) + # Class: (ovarian vein) +AnnotationAssertion(Annotation( "Wikipedia:Ovarian_vein") "A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries.") +AnnotationAssertion( "EMAPA:18644") +AnnotationAssertion( "FMA:14346") +AnnotationAssertion( "MA:0002186") +AnnotationAssertion( "NCIT:C53058") +AnnotationAssertion( "SCTID:278193003") +AnnotationAssertion( "Wikipedia:Ovarian_vein") AnnotationAssertion(rdfs:label "ovarian vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30914,16 +43417,328 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (cystic duct) + +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0009493") "The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct.") +AnnotationAssertion( "EHDAA2:0000333") +AnnotationAssertion( "EHDAA:3045") +AnnotationAssertion( "EMAPA:16841") +AnnotationAssertion( "FMA:14539") +AnnotationAssertion( "GAID:290") +AnnotationAssertion( "MA:0000355") +AnnotationAssertion( "MESH:D003549") +AnnotationAssertion( "NCIT:C32421") +AnnotationAssertion( "SCTID:245398005") +AnnotationAssertion( "TAO:0005166") +AnnotationAssertion( "VHOG:0000213") +AnnotationAssertion( "Wikipedia:Cystic_duct") +AnnotationAssertion( "ZFA:0005166") +AnnotationAssertion( "galen:CysticDuct") +AnnotationAssertion(rdfs:label "cystic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +DisjointClasses( ) + +# Class: (colon) + +AnnotationAssertion(Annotation( "Wikipedia:Colon_(anatomy)") Annotation( "ZFIN:curator") Annotation( "http://orcid.org/0000-0002-2825-0621") Annotation( "http://orcid.org/0000-0002-6601-2165") "A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal.") +AnnotationAssertion( "AAO:0010400") +AnnotationAssertion( "BTO:0000269") +AnnotationAssertion( "CALOHA:TS-0158") +AnnotationAssertion( "EFO:0000361") +AnnotationAssertion( "EMAPA:18939") +AnnotationAssertion( "EV:0100079") +AnnotationAssertion( "FMA:14543") +AnnotationAssertion( "GAID:309") +AnnotationAssertion( "MA:0000335") +AnnotationAssertion( "MAP:0000001") +AnnotationAssertion( "MAT:0000526") +AnnotationAssertion( "MESH:D003106") +AnnotationAssertion( "NCIT:C12382") +AnnotationAssertion( "SCTID:302508007") +AnnotationAssertion( "TAO:0000706") +AnnotationAssertion( "VHOG:0000648") +AnnotationAssertion( "Wikipedia:Colon_(anatomy)") +AnnotationAssertion( "XAO:0000243") +AnnotationAssertion( "ZFA:0000706") +AnnotationAssertion( "galen:Colon") +AnnotationAssertion(rdfs:label "colon") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (sigmoid colon) + +AnnotationAssertion(Annotation( "Wikipedia:Sigmoid_colon") "The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity.") +AnnotationAssertion( "BTO:0000645") +AnnotationAssertion( "CALOHA:TS-2044") +AnnotationAssertion( "EFO:0000846") +AnnotationAssertion( "EMAPA:36391") +AnnotationAssertion( "FMA:14548") +AnnotationAssertion( "MAT:0000314") +AnnotationAssertion( "MESH:D012809") +AnnotationAssertion( "MIAA:0000314") +AnnotationAssertion( "NCIT:C12384") +AnnotationAssertion( "NCIT:C33550") +AnnotationAssertion( "SCTID:362166007") +AnnotationAssertion( "Wikipedia:Sigmoid_colon") +AnnotationAssertion( "galen:SigmoidColon") +AnnotationAssertion(rdfs:label "sigmoid colon") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (body of stomach) + +AnnotationAssertion(Annotation( "GO:0014845") Annotation( "Wikipedia:Body_of_stomach") "The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO].") +AnnotationAssertion( "BTO:0000505") +AnnotationAssertion( "EMAPA:35810") +AnnotationAssertion( "FMA:14560") +AnnotationAssertion( "MA:0002559") +AnnotationAssertion( "NCIT:C12258") +AnnotationAssertion( "SCTID:362140009") +AnnotationAssertion( "Wikipedia:Body_of_stomach") +AnnotationAssertion( "galen:GastricCorpus") +AnnotationAssertion(rdfs:label "body of stomach") +SubClassOf( ) + +# Class: (pyloric antrum) + +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0010790") "The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells.") +AnnotationAssertion( "BTO:0001732") +AnnotationAssertion( "EFO:0002555") +AnnotationAssertion( "EMAPA:17891") +AnnotationAssertion( "FMA:14579") +AnnotationAssertion( "GAID:332") +AnnotationAssertion( "MA:0001624") +AnnotationAssertion( "MESH:D011706") +AnnotationAssertion( "NCIT:C12259") +AnnotationAssertion( "SCTID:362142001") +AnnotationAssertion( "Wikipedia:Pyloric_antrum") +AnnotationAssertion( "galen:PyloricAntrum") +AnnotationAssertion(rdfs:label "pyloric antrum") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pylorus) + +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0010785") "The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum.") +AnnotationAssertion( "BTO:0001146") +AnnotationAssertion( "EHDAA2:0001580") +AnnotationAssertion( "EHDAA:4860") +AnnotationAssertion( "EMAPA:17631") +AnnotationAssertion( "FMA:14581") +AnnotationAssertion( "GAID:333") +AnnotationAssertion( "MA:0002560") +AnnotationAssertion( "MESH:D011708") +AnnotationAssertion( "NCIT:C12260") +AnnotationAssertion( "SCTID:362143006") +AnnotationAssertion( "VHOG:0000420") +AnnotationAssertion( "Wikipedia:Pylorus") +AnnotationAssertion( "galen:Pylorus") +AnnotationAssertion(rdfs:label "pylorus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (wall of stomach) +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0010783") "The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between.") +AnnotationAssertion( "EMAPA:35826") +AnnotationAssertion( "FMA:14582") +AnnotationAssertion( "MA:0002692") +AnnotationAssertion( "SCTID:279995000") +AnnotationAssertion( "galen:WallOfStomach") AnnotationAssertion(rdfs:label "wall of stomach") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (wall of small intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical wall that is part of a small intestine [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35785") +AnnotationAssertion( "FMA:14615") +AnnotationAssertion( "MA:0002696") +AnnotationAssertion( "NCIT:C33573") +AnnotationAssertion(rdfs:label "wall of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (wall of large intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical wall that is part of a large intestine [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35470") +AnnotationAssertion( "FMA:14619") +AnnotationAssertion( "MA:0002695") +AnnotationAssertion(rdfs:label "wall of large intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mesentery of small intestine) + +AnnotationAssertion(Annotation( "Wikipedia:Mesentery#Mesentery_.28proper.29") "The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP].") +AnnotationAssertion( "FMA:14643") +AnnotationAssertion( "MA:0001555") +AnnotationAssertion( "SCTID:245456008") +AnnotationAssertion( "Wikipedia:Mesentery#Mesentery_.28proper.29") +AnnotationAssertion(rdfs:label "mesentery of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (portal lobule) + +AnnotationAssertion(Annotation( "MP:0008992") "The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel.") +AnnotationAssertion( "FMA:14653") +AnnotationAssertion( "MA:0002498") +AnnotationAssertion( "NCIT:C33341") +AnnotationAssertion(rdfs:label "portal lobule") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (hepatic acinus) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/histo_acinus.html") "The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids.") +AnnotationAssertion( "EMAPA:35497") +AnnotationAssertion( "FMA:14654") +AnnotationAssertion( "MA:0002496") +AnnotationAssertion( "NCIT:C32992") +AnnotationAssertion( "SCTID:272214009") +AnnotationAssertion(rdfs:label "hepatic acinus") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (biliary tree) + +AnnotationAssertion(Annotation( "DOI:10.1002/ar.20664") "A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder.") +AnnotationAssertion( "AAO:0011020") +AnnotationAssertion( "EMAPA:35172") +AnnotationAssertion( "FMA:14665") +AnnotationAssertion( "SCTID:181267003") +AnnotationAssertion( "Wikipedia:Biliary_tract") +AnnotationAssertion( "XAO:0000455") +AnnotationAssertion(rdfs:comment "The path in many species is as follows: Bile canaliculi -> Canals of Hering (intralobar bile duct) -> interlobular bile ducts -> intrahepatic bile ducts -> left and right hepatic ducts merge to form -> common hepatic duct *exits liver* and joins -> cystic duct (from gall bladder) forming -> common bile duct -> joins with pancreatic duct -> forming ampulla of Vater -> enters duodenum [WP]") +AnnotationAssertion(rdfs:label "biliary tree") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (common bile duct) + +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0009495") "The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct.") +AnnotationAssertion( "EHDAA2:0000303") +AnnotationAssertion( "EHDAA:3981") +AnnotationAssertion( "EMAPA:17201") +AnnotationAssertion( "FMA:14667") +AnnotationAssertion( "GAID:282") +AnnotationAssertion( "MA:0001631") +AnnotationAssertion( "MESH:D003135") +AnnotationAssertion( "NCIT:C12698") +AnnotationAssertion( "SCTID:362199009") +AnnotationAssertion( "TAO:0005165") +AnnotationAssertion( "VHOG:0000214") +AnnotationAssertion( "Wikipedia:Common_bile_duct") +AnnotationAssertion( "ZFA:0005165") +AnnotationAssertion( "galen:CommonBileDuct") +AnnotationAssertion(rdfs:label "common bile duct") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (common hepatic duct) + +AnnotationAssertion(Annotation( "Wikipedia:Common_hepatic_duct") Annotation( "ZFIN:curator") "Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP].") +AnnotationAssertion( "EMAPA:19101") +AnnotationAssertion( "FMA:14668") +AnnotationAssertion( "GAID:286") +AnnotationAssertion( "MA:0002660") +AnnotationAssertion( "MESH:D006500") +AnnotationAssertion( "NCIT:C32356") +AnnotationAssertion( "SCTID:245403006") +AnnotationAssertion( "VHOG:0000220") +AnnotationAssertion( "Wikipedia:Common_hepatic_duct") +AnnotationAssertion(rdfs:label "common hepatic duct") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (right hepatic duct) + +AnnotationAssertion(Annotation( "http://www.medterms.com/script/main/art.asp?articlekey=26034") "The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct.") +AnnotationAssertion( "EHDAA2:0001727") +AnnotationAssertion( "EHDAA:3992") +AnnotationAssertion( "EMAPA:32797") +AnnotationAssertion( "FMA:14669") +AnnotationAssertion( "MA:0001639") +AnnotationAssertion( "NCIT:C33476") +AnnotationAssertion( "SCTID:245401008") +AnnotationAssertion( "VHOG:0000217") +AnnotationAssertion(rdfs:label "right hepatic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (left hepatic duct) + +AnnotationAssertion(Annotation( "http://www.medterms.com/script/main/art.asp?articlekey=26035") "The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct.") +AnnotationAssertion( "EHDAA2:0000941") +AnnotationAssertion( "EHDAA:3990") +AnnotationAssertion( "EMAPA:32795") +AnnotationAssertion( "FMA:14670") +AnnotationAssertion( "MA:0001638") +AnnotationAssertion( "NCIT:C32960") +AnnotationAssertion( "SCTID:245400009") +AnnotationAssertion( "VHOG:0000218") +AnnotationAssertion(rdfs:label "left hepatic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (visceral peritoneum) +AnnotationAssertion(Annotation( "Wikipedia:Peritoneum#Types") Annotation( "http://orcid.org/0000-0002-6601-2165") "The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space.") +AnnotationAssertion( "EMAPA:16592") +AnnotationAssertion( "FMA:14703") +AnnotationAssertion( "SCTID:362702003") +AnnotationAssertion( "TAO:0005132") +AnnotationAssertion( "VHOG:0001528") +AnnotationAssertion( "Wikipedia:Visceral_peritoneum") +AnnotationAssertion( "ZFA:0005132") AnnotationAssertion(rdfs:label "visceral peritoneum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30931,6 +43746,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (peritoneal cavity) +AnnotationAssertion(Annotation( "Wikipedia:Peritoneal_cavity") Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/86") "Anatomical cavity bounded by visceral and parietal peritoneum.") +AnnotationAssertion( "BTO:0001782") +AnnotationAssertion( "EHDAA2:0001446") +AnnotationAssertion( "EMAPA:16138") +AnnotationAssertion( "FMA:14704") +AnnotationAssertion( "GAID:24") +AnnotationAssertion( "MA:0000054") +AnnotationAssertion( "MESH:D010529") +AnnotationAssertion( "NCIT:C12769") +AnnotationAssertion( "SCTID:181616008") +AnnotationAssertion( "VHOG:0000852") +AnnotationAssertion( "Wikipedia:Peritoneal_cavity") AnnotationAssertion(rdfs:label "peritoneal cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30942,15 +43769,72 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ovarian artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "An artery that supplies an ovary.") +AnnotationAssertion( "EMAPA:18620") +AnnotationAssertion( "FMA:14761") +AnnotationAssertion( "MA:0002012") +AnnotationAssertion( "NCIT:C33242") +AnnotationAssertion( "SCTID:244280002") +AnnotationAssertion( "Wikipedia:Ovarian_artery") AnnotationAssertion(rdfs:label "ovarian artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepatic artery) + +AnnotationAssertion(Annotation( "Wikipedia:Hepatic_artery_proper") Annotation( "https://orcid.org/0000-0002-6601-2165") "An artery that supplies the liver.") +AnnotationAssertion( "BTO:0004307") +AnnotationAssertion( "EMAPA:17859") +AnnotationAssertion( "FMA:14769") +AnnotationAssertion( "GAID:496") +AnnotationAssertion( "MA:0001963") +AnnotationAssertion( "MESH:D006499") +AnnotationAssertion( "NCIT:C32729") +AnnotationAssertion( "SCTID:76015000") +AnnotationAssertion( "TAO:0005161") +AnnotationAssertion( "ZFA:0005161") +AnnotationAssertion( "galen:HepaticArtery") +AnnotationAssertion(rdfs:label "hepatic artery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (splenic artery) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An artery that supplies the spleen.") +AnnotationAssertion( "EMAPA:19216") +AnnotationAssertion( "FMA:14773") +AnnotationAssertion( "GAID:510") +AnnotationAssertion( "MA:0001991") +AnnotationAssertion( "MA:0003177") +AnnotationAssertion( "MESH:D013157") +AnnotationAssertion( "NCIT:C33597") +AnnotationAssertion( "SCTID:244266009") +AnnotationAssertion( "Wikipedia:Splenic_artery") +AnnotationAssertion( "galen:SplenicArtery") +AnnotationAssertion(rdfs:label "splenic artery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +DisjointClasses( ) + # Class: (mucosa of stomach) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The mucosal layer that lines the stomach.") +AnnotationAssertion( "BTO:0001308") +AnnotationAssertion( "CALOHA:TS-0404") +AnnotationAssertion( "EMAPA:35817") +AnnotationAssertion( "FMA:14907") +AnnotationAssertion( "GAID:321") +AnnotationAssertion( "MA:0002683") +AnnotationAssertion( "MESH:D005753") +AnnotationAssertion( "NCIT:C32656") +AnnotationAssertion( "SCTID:362131005") +AnnotationAssertion( "Wikipedia:Gastric_mucosa") +AnnotationAssertion( "galen:GastricMucosa") AnnotationAssertion(rdfs:label "mucosa of stomach") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30960,6 +43844,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (submucosa of stomach) +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0010794") "The fibrous connective tissue layer beneath the stomach mucosa.") +AnnotationAssertion( "BTO:0002110") +AnnotationAssertion( "EMAPA:35825") +AnnotationAssertion( "FMA:14908") +AnnotationAssertion( "MA:0002685") +AnnotationAssertion( "NCIT:C32663") +AnnotationAssertion( "SCTID:52459002") AnnotationAssertion(rdfs:label "submucosa of stomach") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30968,14 +43859,338 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (serosa of stomach) +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0010793") "The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum.") +AnnotationAssertion( "EMAPA:35822") +AnnotationAssertion( "FMA:14914") +AnnotationAssertion( "MA:0001626") +AnnotationAssertion( "NCIT:C32662") +AnnotationAssertion( "SCTID:1353004") AnnotationAssertion(rdfs:label "serosa of stomach") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pyloric sphincter) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP].") +AnnotationAssertion( "AAO:0011093") +AnnotationAssertion( "EMAPA:19251") +AnnotationAssertion( "FMA:14916") +AnnotationAssertion( "MA:0002952") +AnnotationAssertion( "NCIT:C33433") +AnnotationAssertion( "SCTID:268073008") +AnnotationAssertion( "VHOG:0001466") +AnnotationAssertion( "XAO:0000457") +AnnotationAssertion(rdfs:label "pyloric sphincter") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of small intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a small intestine [Automatically generated definition].") +AnnotationAssertion( "BTO:0001259") +AnnotationAssertion( "CALOHA:TS-0941") +AnnotationAssertion( "EMAPA:35780") +AnnotationAssertion( "FMA:14933") +AnnotationAssertion( "MA:0002686") +AnnotationAssertion( "NCIT:C33568") +AnnotationAssertion( "SCTID:362144000") +AnnotationAssertion(rdfs:label "mucosa of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of small intestine) + +AnnotationAssertion(Annotation( "Wikipedia:Small_intestinal_submucosa") "Submucosal tissue in the small intestines.") +AnnotationAssertion( "BTO:0002112") +AnnotationAssertion( "FMA:14934") +AnnotationAssertion( "MA:0001562") +AnnotationAssertion( "NCIT:C33572") +AnnotationAssertion( "SCTID:691000") +AnnotationAssertion( "Wikipedia:Small_intestinal_submucosa") +AnnotationAssertion(rdfs:label "submucosa of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (serosa of small intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A serous membrane that is part of a small intestine [Automatically generated definition].") +AnnotationAssertion( "FMA:14938") +AnnotationAssertion( "MA:0001558") +AnnotationAssertion( "SCTID:8266009") +AnnotationAssertion(rdfs:label "serosa of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of large intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a large intestine [Automatically generated definition].") +AnnotationAssertion( "CALOHA:TS-2106") +AnnotationAssertion( "EMAPA:35467") +AnnotationAssertion( "FMA:14969") +AnnotationAssertion( "MA:0002688") +AnnotationAssertion( "NCIT:C32926") +AnnotationAssertion(rdfs:label "mucosa of large intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of large intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a large intestine [Automatically generated definition].") +AnnotationAssertion( "BTO:0002111") +AnnotationAssertion( "FMA:14970") +AnnotationAssertion( "MA:0002690") +AnnotationAssertion( "NCIT:C32930") +AnnotationAssertion(rdfs:label "submucosa of large intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (serosa of large intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A serous membrane that is part of a large intestine [Automatically generated definition].") +AnnotationAssertion( "FMA:14975") +AnnotationAssertion( "MA:0001546") +AnnotationAssertion( "NCIT:C32929") +AnnotationAssertion(rdfs:label "serosa of large intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (duodenal gland) + +AnnotationAssertion(Annotation( "Wikipedia:Brunner's_glands") "A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP].") +AnnotationAssertion( "BTO:0002376") +AnnotationAssertion( "EMAPA:36522") +AnnotationAssertion( "FMA:15060") +AnnotationAssertion( "GAID:314") +AnnotationAssertion( "MA:0001551") +AnnotationAssertion( "MESH:D002011") +AnnotationAssertion( "NCIT:C13010") +AnnotationAssertion( "SCTID:41298001") +AnnotationAssertion( "Wikipedia:Brunner's_glands") +AnnotationAssertion(rdfs:label "duodenal gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (intestinal villus) + +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MGI:rbabiuk") Annotation( "MP:0008108") "The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold.") +AnnotationAssertion( "BTO:0003121") +AnnotationAssertion( "EMAPA:35784") +AnnotationAssertion( "FMA:15072") +AnnotationAssertion( "MA:0001563") +AnnotationAssertion( "NCIT:C33874") +AnnotationAssertion( "SCTID:23230007") +AnnotationAssertion( "TAO:0005125") +AnnotationAssertion( "Wikipedia:Intestinal_villus") +AnnotationAssertion( "ZFA:0005125") +AnnotationAssertion(rdfs:label "intestinal villus") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (inferior mesenteric vein) + +AnnotationAssertion(Annotation( "Wikipedia:Inferior_mesenteric_vein") "A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted].") +AnnotationAssertion( "BTO:0002782") +AnnotationAssertion( "EHDAA2:0000819") +AnnotationAssertion( "EHDAA:8712") +AnnotationAssertion( "EMAPA:18642") +AnnotationAssertion( "FMA:15391") +AnnotationAssertion( "MA:0002178") +AnnotationAssertion( "NCIT:C32782") +AnnotationAssertion( "SCTID:281055007") +AnnotationAssertion( "VHOG:0001118") +AnnotationAssertion( "Wikipedia:Inferior_mesenteric_vein") +AnnotationAssertion(rdfs:label "inferior mesenteric vein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (lamina propria of small intestine) + +AnnotationAssertion(Annotation( "GOC:Obol") "Lamina propria that is part_of the small intestine.") +AnnotationAssertion( "EMAPA:35779") +AnnotationAssertion( "FMA:15651") +AnnotationAssertion( "MA:0001554") +AnnotationAssertion( "NCIT:C49297") +AnnotationAssertion( "SCTID:63588008") +AnnotationAssertion(rdfs:label "lamina propria of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (intestinal mucosa) + +AnnotationAssertion(Annotation( "UBERON:cjm") "Mucosal layer that lines the intestine.") +AnnotationAssertion( "BTO:0000642") +AnnotationAssertion( "EMAPA:35440") +AnnotationAssertion( "FMA:15695") +AnnotationAssertion( "GAID:296") +AnnotationAssertion( "MA:0001537") +AnnotationAssertion( "MESH:D007413") +AnnotationAssertion( "NCIT:C49241") +AnnotationAssertion( "SCTID:362080002") +AnnotationAssertion(rdfs:label "intestinal mucosa") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (serosa of intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A serous membrane that is part of a wall of intestine [Automatically generated definition].") +AnnotationAssertion( "FMA:15701") +AnnotationAssertion( "MA:0001538") +AnnotationAssertion(rdfs:label "serosa of intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (anus) + +AnnotationAssertion(Annotation( "Wikipedia:Anus") Annotation( "ZFIN:curator") "Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts.") +AnnotationAssertion( "BTO:0001680") +AnnotationAssertion( "CALOHA:TS-2005") +AnnotationAssertion( "EV:0100082") +AnnotationAssertion( "FMA:15711") +AnnotationAssertion( "GAID:312") +AnnotationAssertion( "MA:0000331") +AnnotationAssertion( "NCIT:C43362") +AnnotationAssertion( "SCTID:181262009") +AnnotationAssertion( "TADS:0000066") +AnnotationAssertion( "TGMA:0001279") +AnnotationAssertion( "WBbt:0005364") +AnnotationAssertion( "Wikipedia:Anus") +AnnotationAssertion( "galen:Anus") +AnnotationAssertion(rdfs:label "anus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (interlobular bile duct) + +AnnotationAssertion(Annotation( "MP:0009500") "The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad.") +AnnotationAssertion( "FMA:15767") +AnnotationAssertion( "MA:0002668") +AnnotationAssertion( "NCIT:C32827") +AnnotationAssertion( "SCTID:83488001") +AnnotationAssertion( "Wikipedia:Interlobular_bile_ducts") +AnnotationAssertion(rdfs:label "interlobular bile duct") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (wall of intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical wall that is part of a intestine [Automatically generated definition].") +AnnotationAssertion( "BTO:0000647") +AnnotationAssertion( "EMAPA:35444") +AnnotationAssertion( "FMA:15949") +AnnotationAssertion( "MA:0001525") +AnnotationAssertion( "MA:0002693") +AnnotationAssertion( "NCIT:C49478") +AnnotationAssertion(rdfs:label "wall of intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreatic acinus) + +AnnotationAssertion(Annotation( "MP:0009145") "The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct.") +AnnotationAssertion( "EMAPA:35651") +AnnotationAssertion( "FMA:16011") +AnnotationAssertion( "MA:0002417") +AnnotationAssertion( "NCIT:C49268") +AnnotationAssertion( "SCTID:247604006") +AnnotationAssertion(rdfs:label "pancreatic acinus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreas) + +AnnotationAssertion(Annotation( "GO:0031016") "An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO].") +AnnotationAssertion( "AAO:0010112") +AnnotationAssertion( "BTO:0000988") +AnnotationAssertion( "CALOHA:TS-0736") +AnnotationAssertion( "EFO:0000855") +AnnotationAssertion( "EHDAA2:0001367") +AnnotationAssertion( "EHDAA:6893") +AnnotationAssertion( "EMAPA:17503") +AnnotationAssertion( "EV:0100092") +AnnotationAssertion( "FMA:7198") +AnnotationAssertion( "GAID:334") +AnnotationAssertion( "MA:0000120") +AnnotationAssertion( "MAT:0000075") +AnnotationAssertion( "MESH:D010179") +AnnotationAssertion( "MIAA:0000075") +AnnotationAssertion( "NCIT:C12393") +AnnotationAssertion( "SCTID:181277001") +AnnotationAssertion( "TAO:0000140") +AnnotationAssertion( "VHOG:0000050") +AnnotationAssertion( "Wikipedia:Pancreas") +AnnotationAssertion( "XAO:0000136") +AnnotationAssertion( "ZFA:0000140") +AnnotationAssertion( "galen:Pancreas") +AnnotationAssertion(rdfs:label "pancreas") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (trabecula of spleen) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A trabecula that is part of a spleen.") +AnnotationAssertion( "EMAPA:35808") +AnnotationAssertion( "FMA:16027") +AnnotationAssertion( "MA:0000758") +AnnotationAssertion( "NCIT:C33607") +AnnotationAssertion( "SCTID:61987002") +AnnotationAssertion( "Wikipedia:Trabeculae_of_spleen") +AnnotationAssertion(rdfs:label "trabecula of spleen") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (peritoneal fluid) +AnnotationAssertion(Annotation( "FMA:16515") "Transudate contained in the peritoneal cavity.") +AnnotationAssertion( "BTO:0001031") +AnnotationAssertion( "EMAPA:35683") +AnnotationAssertion( "FMA:16515") +AnnotationAssertion( "MA:0002531") +AnnotationAssertion( "Wikipedia:Peritoneal_fluid") +AnnotationAssertion( "ncithesaurus:Peritoneal_Fluid") AnnotationAssertion(rdfs:label "peritoneal fluid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30985,6 +44200,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelium of stomach) +AnnotationAssertion(Annotation( "MP:0000471") "The epithelial layer of the stomach .") +AnnotationAssertion( "BTO:0000500") +AnnotationAssertion( "CALOHA:TS-2068") +AnnotationAssertion( "EHDAA2:0001918") +AnnotationAssertion( "EMAPA:17023") +AnnotationAssertion( "FMA:17091") +AnnotationAssertion( "MA:0001610") +AnnotationAssertion( "SCTID:64977002") +AnnotationAssertion( "VHOG:0001433") AnnotationAssertion(rdfs:label "epithelium of stomach") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -30994,8 +44218,150 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (intestinal epithelium) + +AnnotationAssertion(Annotation( "UBERON:cjm") "Epithelial layer that lines the intestine.") +AnnotationAssertion( "BTO:0000781") +AnnotationAssertion( "EMAPA:32873") +AnnotationAssertion( "FMA:17229") +AnnotationAssertion( "MA:0001536") +AnnotationAssertion( "NCIT:C49240") +AnnotationAssertion( "SCTID:266135004") +AnnotationAssertion( "TAO:0005124") +AnnotationAssertion( "Wikipedia:Intestinal_epithelium") +AnnotationAssertion( "ZFA:0005124") +AnnotationAssertion(rdfs:label "intestinal epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (epithelium of large intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a large intestine [Automatically generated definition].") +AnnotationAssertion( "CALOHA:TS-2105") +AnnotationAssertion( "EMAPA:35466") +AnnotationAssertion( "FMA:17301") +AnnotationAssertion( "MA:0001545") +AnnotationAssertion(rdfs:label "epithelium of large intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (portal triad) + +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MGI:csmith") Annotation( "MP:0008993") Annotation( "http://orcid.org/0000-0002-6601-2165") "A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel.") +AnnotationAssertion( "FMA:17523") +AnnotationAssertion( "MA:0002499") +AnnotationAssertion( "NCIT:C33342") +AnnotationAssertion( "SCTID:362192000") +AnnotationAssertion( "Wikipedia:Portal_triad") +AnnotationAssertion(rdfs:label "portal triad") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (liver parenchyma) + +AnnotationAssertion(Annotation( "MP:0008986") "The functional units of the liver including the lobules.") +AnnotationAssertion( "AAO:0010405") +AnnotationAssertion( "EHDAA2:0001004") +AnnotationAssertion( "EHDAA:2201") +AnnotationAssertion( "EMAPA:17203") +AnnotationAssertion( "FMA:17540") +AnnotationAssertion( "MA:0000366") +AnnotationAssertion( "NCIT:C32735") +AnnotationAssertion( "SCTID:363535004") +AnnotationAssertion( "UMLS:C0736268") +AnnotationAssertion( "VHOG:0000539") +AnnotationAssertion( "XAO:0000454") +AnnotationAssertion(rdfs:label "liver parenchyma") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (hepatic sinusoid) + +AnnotationAssertion(Annotation( "Wikipedia:Hepatic_sinusoid") Annotation( "ZFIN:curator") "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers.") +AnnotationAssertion( "EHDAA2:0000999") +AnnotationAssertion( "EMAPA:17365") +AnnotationAssertion( "FMA:17543") +AnnotationAssertion( "MA:0000367") +AnnotationAssertion( "NCIT:C32733") +AnnotationAssertion( "SCTID:67435004") +AnnotationAssertion( "TAO:0005091") +AnnotationAssertion( "VHOG:0000708") +AnnotationAssertion( "Wikipedia:Hepatic_sinusoid") +AnnotationAssertion( "ZFA:0005091") +AnnotationAssertion(rdfs:label "hepatic sinusoid") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (intralobular bile duct) + +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0009499") "The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule.") +AnnotationAssertion( "FMA:17545") +AnnotationAssertion( "MA:0002669") +AnnotationAssertion( "NCIT:C32255") +AnnotationAssertion( "SCTID:227002") +AnnotationAssertion( "SCTID:269922006") +AnnotationAssertion( "Wikipedia:Canals_of_Hering") +AnnotationAssertion(rdfs:label "intralobular bile duct") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (anal region) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "The anus and surrounding regions. Encompasses both internal and external regions, where present.") +AnnotationAssertion( "EFO:0000847") +AnnotationAssertion( "EHDAA2:0000122") +AnnotationAssertion( "EHDAA:2931") +AnnotationAssertion( "EMAPA:16831") +AnnotationAssertion( "MA:0000329") +AnnotationAssertion( "MAT:0000042") +AnnotationAssertion( "MIAA:0000042") +AnnotationAssertion( "NCIT:C32069") +AnnotationAssertion( "SCTID:362680001") +AnnotationAssertion( "VHOG:0000395") +AnnotationAssertion( "WBbt:0006919") +AnnotationAssertion(rdfs:label "anal region") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (parietal peritoneum) +AnnotationAssertion(Annotation( "Wikipedia:Peritoneum#Types") Annotation( "http://orcid.org/0000-0002-6601-2165") "The outer layer of peritoneum that is attached to the abdominal and pelvic walls.") +AnnotationAssertion( "AAO:0010816") +AnnotationAssertion( "EMAPA:16591") +AnnotationAssertion( "FMA:21451") +AnnotationAssertion( "SCTID:362700006") +AnnotationAssertion( "TAO:0005131") +AnnotationAssertion( "VHOG:0001527") +AnnotationAssertion( "Wikipedia:Parietal_peritoneum") +AnnotationAssertion( "ZFA:0005131") AnnotationAssertion(rdfs:label "parietal peritoneum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31004,6 +44370,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin of abdomen) +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of an abdomen [Automatically generated definition].") +AnnotationAssertion( "EFO:0000214") +AnnotationAssertion( "FMA:22988") +AnnotationAssertion( "FMA:23000") +AnnotationAssertion( "MA:0000523") +AnnotationAssertion( "NCIT:C52758") +AnnotationAssertion( "SCTID:361707007") AnnotationAssertion(rdfs:label "skin of abdomen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31011,6 +44384,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin of neck) +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a neck [Automatically generated definition].") +AnnotationAssertion( "FMA:23021") +AnnotationAssertion( "FMA:23022") +AnnotationAssertion( "MA:0000590") +AnnotationAssertion( "NCIT:C52756") +AnnotationAssertion( "SCTID:361705004") AnnotationAssertion(rdfs:label "skin of neck") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31018,6 +44397,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin of thorax) +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a thorax [Automatically generated definition].") +AnnotationAssertion( "FMA:23028") +AnnotationAssertion( "FMA:23029") +AnnotationAssertion( "MA:0000564") +AnnotationAssertion( "SCTID:281723000") AnnotationAssertion(rdfs:label "skin of thorax") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31025,6 +44409,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral girdle region) +AnnotationAssertion(Annotation( "FMA:23217") Annotation( "UBERONREF:0000003") Annotation( "https://orcid.org/0000-0002-6601-2165") "An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions.") +AnnotationAssertion( "FMA:23217") +AnnotationAssertion( "SCTID:229759004") +AnnotationAssertion( "VSAO:0000305") +AnnotationAssertion( "galen:ShoulderGirdle") AnnotationAssertion(rdfs:label "pectoral girdle region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31036,6 +44425,21 @@ DisjointClasses( (skeletal system) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "VSAO:0000027") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.") +AnnotationAssertion( "AAO:0000566") +AnnotationAssertion( "BTO:0001486") +AnnotationAssertion( "CALOHA:TS-1320") +AnnotationAssertion( "EFO:0000806") +AnnotationAssertion( "EHDAA2:0003168") +AnnotationAssertion( "EMAPA:35773") +AnnotationAssertion( "FMA:23881") +AnnotationAssertion( "MA:0000018") +AnnotationAssertion( "NCIT:C12788") +AnnotationAssertion( "TAO:0000434") +AnnotationAssertion( "VHOG:0001254") +AnnotationAssertion( "VSAO:0000027") +AnnotationAssertion( "XAO:0003060") +AnnotationAssertion( "ZFA:0000434") AnnotationAssertion(rdfs:label "skeletal system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31045,21 +44449,39 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) # Class: (subdivision of head) +AnnotationAssertion( "FMA:24218") +AnnotationAssertion( "SCTID:123852005") +AnnotationAssertion( "XAO:0000040") AnnotationAssertion(rdfs:label "subdivision of head") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (face) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc).") +AnnotationAssertion( "BTO:0003369") +AnnotationAssertion( "CALOHA:TS-2216") +AnnotationAssertion( "EMAPA:32763") +AnnotationAssertion( "FMA:24728") +AnnotationAssertion( "GAID:64") +AnnotationAssertion( "HAO:0000316") +AnnotationAssertion( "MA:0002473") +AnnotationAssertion( "MESH:D005145") +AnnotationAssertion( "NCIT:C13071") +AnnotationAssertion( "SCTID:302549007") +AnnotationAssertion( "Wikipedia:Face") +AnnotationAssertion( "galen:Face") AnnotationAssertion(rdfs:label "face") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31067,6 +44489,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin of lip) +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a lip [Automatically generated definition].") +AnnotationAssertion( "FMA:24764") +AnnotationAssertion( "MA:0001579") +AnnotationAssertion( "NCIT:C12291") +AnnotationAssertion( "SCTID:244092005") AnnotationAssertion(rdfs:label "skin of lip") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31074,6 +44501,31 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bone element) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000057") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "https://github.com/obophenotype/uberon/issues/277") "Skeletal element that is composed of bone tissue.") +AnnotationAssertion( "AAO:0000047") +AnnotationAssertion( "AEO:0000082") +AnnotationAssertion( "BTO:0000140") +AnnotationAssertion( "CALOHA:TS-0088") +AnnotationAssertion( "EFO:0000298") +AnnotationAssertion( "EHDAA2:0003082") +AnnotationAssertion( "EMAPA:32782") +AnnotationAssertion( "ENVO:00002039") +AnnotationAssertion( "EV:0100140") +AnnotationAssertion( "FMA:30317") +AnnotationAssertion( "FMA:5018") +AnnotationAssertion( "GAID:92") +AnnotationAssertion( "MA:0001459") +AnnotationAssertion( "MAT:0000299") +AnnotationAssertion( "MIAA:0000299") +AnnotationAssertion( "NCIT:C12366") +AnnotationAssertion( "SCTID:90780006") +AnnotationAssertion( "TAO:0001514") +AnnotationAssertion( "VHOG:0001190") +AnnotationAssertion( "VSAO:0000057") +AnnotationAssertion( "Wikipedia:Bone") +AnnotationAssertion( "XAO:0000169") +AnnotationAssertion( "ZFA:0001514") +AnnotationAssertion( "galen:Bone") AnnotationAssertion(rdfs:label "bone element") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31084,6 +44536,16 @@ DisjointClasses( (articular capsule) +AnnotationAssertion(Annotation( "Wikipedia:Articular_capsule") "An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted].") +AnnotationAssertion( "FMA:34836") +AnnotationAssertion( "GAID:263") +AnnotationAssertion( "MA:0001519") +AnnotationAssertion( "MESH:D017746") +AnnotationAssertion( "NCIT:C32259") +AnnotationAssertion( "NCIT:C84388") +AnnotationAssertion( "SCTID:182238002") +AnnotationAssertion( "Wikipedia:Articular_capsule") +AnnotationAssertion( "galen:JointCapsule") AnnotationAssertion(rdfs:label "articular capsule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31092,7 +44554,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ascending aorta) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0035905") Annotation( "Wikipedia:Ascending_aorta") "The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia].") +AnnotationAssertion( "EHDAA2:0000147") +AnnotationAssertion( "EHDAA:9828") +AnnotationAssertion( "EMAPA:17014") +AnnotationAssertion( "FMA:3736") +AnnotationAssertion( "MA:0002570") +AnnotationAssertion( "NCIT:C32150") +AnnotationAssertion( "SCTID:181299009") +AnnotationAssertion( "Wikipedia:Ascending_aorta") AnnotationAssertion(rdfs:label "ascending aorta") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31103,7 +44573,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (arch of aorta) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0004113") "The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery.") +AnnotationAssertion( "BTO:0000157") +AnnotationAssertion( "EFO:0002526") +AnnotationAssertion( "EHDAA2:0000132") +AnnotationAssertion( "EMAPA:17613") +AnnotationAssertion( "FMA:3768") +AnnotationAssertion( "GAID:471") +AnnotationAssertion( "MA:0000475") +AnnotationAssertion( "SCTID:181300001") +AnnotationAssertion( "VHOG:0001196") +AnnotationAssertion( "Wikipedia:Arch_of_aorta") AnnotationAssertion(rdfs:label "arch of aorta") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31115,7 +44595,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (descending aorta) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0035906") Annotation( "Wikipedia:Descending_aorta") "The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted].") +AnnotationAssertion( "EMAPA:18606") +AnnotationAssertion( "FMA:3784") +AnnotationAssertion( "MA:0002571") +AnnotationAssertion( "NCIT:C32455") +AnnotationAssertion( "SCTID:261399002") +AnnotationAssertion( "Wikipedia:Descending_aorta") AnnotationAssertion(rdfs:label "descending aorta") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31125,6 +44611,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic aorta) +AnnotationAssertion(Annotation( "MP:0010468") Annotation( "http://www.medterms.com") "The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.") +AnnotationAssertion( "BTO:0000157") +AnnotationAssertion( "EFO:0002525") +AnnotationAssertion( "EMAPA:18603") +AnnotationAssertion( "FMA:3786") +AnnotationAssertion( "GAID:471") +AnnotationAssertion( "MA:0002569") +AnnotationAssertion( "MESH:D001013") +AnnotationAssertion( "NCIT:C33766") +AnnotationAssertion( "SCTID:302510009") +AnnotationAssertion( "Wikipedia:Thoracic_aorta") +AnnotationAssertion( "galen:ThoracicAorta") AnnotationAssertion(rdfs:label "thoracic aorta") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31133,7 +44631,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdominal aorta) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "BTO:0002976") Annotation( "Wikipedia:Abdominal_aorta") "Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted].") +AnnotationAssertion( "BTO:0002976") +AnnotationAssertion( "EFO:0002524") +AnnotationAssertion( "EMAPA:17856") +AnnotationAssertion( "FMA:3789") +AnnotationAssertion( "GAID:470") +AnnotationAssertion( "MA:0000474") +AnnotationAssertion( "MESH:D001012") +AnnotationAssertion( "NCIT:C32038") +AnnotationAssertion( "SCTID:244231007") +AnnotationAssertion( "Wikipedia:Abdominal_aorta") +AnnotationAssertion( "galen:AbdominalAorta") AnnotationAssertion(rdfs:label "abdominal aorta") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31143,7 +44652,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (brachiocephalic artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0010663") "The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery.") +AnnotationAssertion( "EFO:0002550") +AnnotationAssertion( "EHDAA2:0000835") +AnnotationAssertion( "EMAPA:17615") +AnnotationAssertion( "FMA:3932") +AnnotationAssertion( "GAID:476") +AnnotationAssertion( "MA:0001922") +AnnotationAssertion( "MESH:D016122") +AnnotationAssertion( "NCIT:C32814") +AnnotationAssertion( "SCTID:244244002") +AnnotationAssertion( "Wikipedia:Brachiocephalic_artery") +AnnotationAssertion( "galen:BrachioCephalicArtery") AnnotationAssertion(rdfs:label "brachiocephalic artery") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31152,7 +44672,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (common carotid artery plus branches) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Common_carotid_artery") "A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm].") +AnnotationAssertion( "CALOHA:TS-0116") +AnnotationAssertion( "EHDAA2:0000217") +AnnotationAssertion( "EHDAA:7331") +AnnotationAssertion( "EMAPA:17855") +AnnotationAssertion( "FMA:3939") +AnnotationAssertion( "GAID:479") +AnnotationAssertion( "MA:0001926") +AnnotationAssertion( "MESH:D017536") +AnnotationAssertion( "NCIT:C32352") +AnnotationAssertion( "SCTID:362041005") +AnnotationAssertion( "VHOG:0000272") +AnnotationAssertion( "Wikipedia:Common_carotid_artery") AnnotationAssertion(rdfs:label "common carotid artery plus branches") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31161,7 +44693,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (subclavian artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "https://orcid.org/0000-0002-6601-2165") "One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta.") +AnnotationAssertion( "AAO:0010232") +AnnotationAssertion( "EHDAA2:0001933") +AnnotationAssertion( "EHDAA:4357") +AnnotationAssertion( "EMAPA:17617") +AnnotationAssertion( "FMA:3951") +AnnotationAssertion( "GAID:511") +AnnotationAssertion( "MA:0002045") +AnnotationAssertion( "MESH:D013348") +AnnotationAssertion( "NCIT:C33643") +AnnotationAssertion( "SCTID:265790007") +AnnotationAssertion( "TAO:0005086") +AnnotationAssertion( "Wikipedia:Subclavian_artery") +AnnotationAssertion( "XAO:0000365") +AnnotationAssertion( "ZFA:0005086") AnnotationAssertion(rdfs:label "subclavian artery") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31172,7 +44718,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right subclavian artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The subclavian artery that supplies the right pectoral appendage.") +AnnotationAssertion( "EHDAA2:0004514") +AnnotationAssertion( "FMA:3953") +AnnotationAssertion( "MA:0002047") +AnnotationAssertion( "NCIT:C33490") +AnnotationAssertion( "SCTID:244246000") +AnnotationAssertion( "Wikipedia:Subclavian_artery") AnnotationAssertion(rdfs:label "right subclavian artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31182,7 +44734,23 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (digestive tract) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Talk:Human_gastrointestinal_tract") Annotation( "https://github.com/geneontology/go-ontology/issues/7549") "A tube extending from the mouth to the anus.") +AnnotationAssertion( "AAO:0010023") +AnnotationAssertion( "BILA:0000083") +AnnotationAssertion( "BTO:0000511") +AnnotationAssertion( "BTO:0000545") +AnnotationAssertion( "EHDAA2:0000726") +AnnotationAssertion( "EHDAA:518") +AnnotationAssertion( "EMAPA:16247") +AnnotationAssertion( "FMA:45615") +AnnotationAssertion( "MA:0000917") +AnnotationAssertion( "NCIT:C34082") +AnnotationAssertion( "TAO:0000112") +AnnotationAssertion( "TGMA:0001819") +AnnotationAssertion( "VHOG:0000309") +AnnotationAssertion( "WBbt:0005743") +AnnotationAssertion( "ZFA:0000112") +AnnotationAssertion( "galen:AlimentaryTract") AnnotationAssertion(rdfs:label "digestive tract") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31192,14 +44760,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lower respiratory tract) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Lower_respiratory_tract") Annotation( "http://orcid.org/0000-0002-6601-2165") "The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified].") +AnnotationAssertion( "EHDAA2:0001036") +AnnotationAssertion( "EMAPA:16738") +AnnotationAssertion( "FMA:45662") +AnnotationAssertion( "MA:0000435") +AnnotationAssertion( "SCTID:281488008") +AnnotationAssertion( "VHOG:0000382") +AnnotationAssertion( "Wikipedia:Lower_respiratory_tract") AnnotationAssertion(rdfs:label "lower respiratory tract") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (left subclavian artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The subclavian artery that supplies the left pectoral appendage.") +AnnotationAssertion( "FMA:4694") +AnnotationAssertion( "MA:0002046") +AnnotationAssertion( "NCIT:C32972") +AnnotationAssertion( "SCTID:244245001") +AnnotationAssertion( "Wikipedia:Subclavian_artery") AnnotationAssertion(rdfs:label "left subclavian artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31209,7 +44789,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anterior vena cava) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Superior_vena_cava") Annotation( "http://orcid.org/0000-0002-6601-2165") "A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart.") +AnnotationAssertion( "BTO:0002683") +AnnotationAssertion( "EHDAA2:0001962") +AnnotationAssertion( "EHDAA:8726") +AnnotationAssertion( "EMAPA:18417") +AnnotationAssertion( "FMA:4720") +AnnotationAssertion( "GAID:549") +AnnotationAssertion( "MA:0000481") +AnnotationAssertion( "MESH:D014683") +AnnotationAssertion( "NCIT:C12816") +AnnotationAssertion( "SCTID:181368006") +AnnotationAssertion( "VHOG:0001195") +AnnotationAssertion( "Wikipedia:Superior_vena_cava") +AnnotationAssertion( "galen:SuperiorVenaCava") AnnotationAssertion(rdfs:label "anterior vena cava") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31218,7 +44811,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (internal jugular vein) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Internal_jugular_vein") "One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted].") +AnnotationAssertion( "AAO:0010236") +AnnotationAssertion( "EHDAA2:0000877") +AnnotationAssertion( "EHDAA:5407") +AnnotationAssertion( "EMAPA:17620") +AnnotationAssertion( "FMA:4724") +AnnotationAssertion( "MA:0002157") +AnnotationAssertion( "NCIT:C32849") +AnnotationAssertion( "RETIRED_EHDAA2:0000878") +AnnotationAssertion( "SCTID:181372005") +AnnotationAssertion( "Wikipedia:Internal_jugular_vein") +AnnotationAssertion( "XAO:0000382") +AnnotationAssertion( "galen:InternalJugularVein") AnnotationAssertion(rdfs:label "internal jugular vein") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31227,7 +44832,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bronchial vein) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Bronchial_veins") "The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted].") +AnnotationAssertion( "EMAPA:36284") +AnnotationAssertion( "FMA:4749") +AnnotationAssertion( "MA:0002088") +AnnotationAssertion( "NCIT:C53031") +AnnotationAssertion( "SCTID:198293000") +AnnotationAssertion( "Wikipedia:Bronchial_veins") AnnotationAssertion(rdfs:label "bronchial vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31235,7 +44846,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ciliary muscle) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Ciliary_muscle") "The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted].") +AnnotationAssertion( "BTO:0000654") +AnnotationAssertion( "EMAPA:35240") +AnnotationAssertion( "FMA:49151") +AnnotationAssertion( "MA:0001269") +AnnotationAssertion( "NCIT:C32315") +AnnotationAssertion( "SCTID:280862009") +AnnotationAssertion( "Wikipedia:Ciliary_muscle") AnnotationAssertion(rdfs:label "ciliary muscle") SubClassOf( ) SubClassOf( ) @@ -31244,14 +44862,61 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (muscle of iris) +AnnotationAssertion( "FMA:49154") +AnnotationAssertion( "MA:0001287") +AnnotationAssertion( "SCTID:280888007") +AnnotationAssertion( "Wikipedia:Iris_muscle") AnnotationAssertion(rdfs:label "muscle of iris") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (sphincter pupillae) + +AnnotationAssertion(Annotation( "Wikipedia:Iris_sphincter_muscle") "A sphincter muscle that is part of the iris.") +AnnotationAssertion( "BTO:0000656") +AnnotationAssertion( "EMAPA:35788") +AnnotationAssertion( "FMA:49157") +AnnotationAssertion( "MA:0001289") +AnnotationAssertion( "NCIT:C33586") +AnnotationAssertion( "SCTID:280889004") +AnnotationAssertion( "Wikipedia:Iris_sphincter_muscle") +AnnotationAssertion(rdfs:label "sphincter pupillae") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (dilatator pupillae) + +AnnotationAssertion(Annotation( "Wikipedia:Iris_dilator_muscle") "A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted].") +AnnotationAssertion( "BTO:0001371") +AnnotationAssertion( "EMAPA:35286") +AnnotationAssertion( "FMA:49158") +AnnotationAssertion( "MA:0001288") +AnnotationAssertion( "NCIT:C32463") +AnnotationAssertion( "SCTID:280890008") +AnnotationAssertion( "Wikipedia:Iris_dilator_muscle") +AnnotationAssertion(rdfs:label "dilatator pupillae") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (facial artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Facial_artery") "A branch of the external carotid artery that supplies structures of the face. [WP,unvetted].") +AnnotationAssertion( "EMAPA:19213") +AnnotationAssertion( "FMA:49549") +AnnotationAssertion( "MA:0001950") +AnnotationAssertion( "NCIT:C32578") +AnnotationAssertion( "SCTID:181328007") +AnnotationAssertion( "Wikipedia:Facial_artery") AnnotationAssertion(rdfs:label "facial artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31259,6 +44924,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (muscle organ) +AnnotationAssertion(Annotation( "GO:0007517") "Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO].") +AnnotationAssertion( "EV:0100146") +AnnotationAssertion( "FMA:5022") +AnnotationAssertion( "GAID:131") +AnnotationAssertion( "MA:0000015") +AnnotationAssertion( "SCTID:71616004") +AnnotationAssertion( "TAO:0005145") +AnnotationAssertion( "VHOG:0001245") +AnnotationAssertion( "XAO:0000172") +AnnotationAssertion( "ZFA:0005145") +AnnotationAssertion( "galen:Muscle") AnnotationAssertion(rdfs:label "muscle organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31268,21 +44944,127 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (artery) +AnnotationAssertion(Annotation( "AEO:JB") "An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition].") +AnnotationAssertion( "AAO:0010211") +AnnotationAssertion( "AEO:0000208") +AnnotationAssertion( "BTO:0000573") +AnnotationAssertion( "CALOHA:TS-0054") +AnnotationAssertion( "EFO:0000814") +AnnotationAssertion( "EHDAA2:0003253") +AnnotationAssertion( "EMAPA:35147") +AnnotationAssertion( "EV:0100026") +AnnotationAssertion( "FMA:50720") +AnnotationAssertion( "GAID:468") +AnnotationAssertion( "MA:0000064") +AnnotationAssertion( "MAT:0000034") +AnnotationAssertion( "MESH:D001158") +AnnotationAssertion( "MIAA:0000034") +AnnotationAssertion( "NCIT:C12372") +AnnotationAssertion( "SCTID:362877004") +AnnotationAssertion( "TAO:0000005") +AnnotationAssertion( "VHOG:0001251") +AnnotationAssertion( "Wikipedia:Artery") +AnnotationAssertion( "XAO:0000114") +AnnotationAssertion( "ZFA:0000005") +AnnotationAssertion( "galen:Artery") AnnotationAssertion(rdfs:label "artery") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vein) +AnnotationAssertion(Annotation( "Wikipedia:Vein") "Any of the tubular branching vessels that carry blood from the capillaries toward the heart.") +AnnotationAssertion( "AAO:0010212") +AnnotationAssertion( "AEO:0000209") +AnnotationAssertion( "BTO:0000234") +AnnotationAssertion( "CALOHA:TS-1108") +AnnotationAssertion( "EFO:0000816") +AnnotationAssertion( "EHDAA2:0003254") +AnnotationAssertion( "EMAPA:35906") +AnnotationAssertion( "EV:0100031") +AnnotationAssertion( "FMA:50723") +AnnotationAssertion( "GAID:492") +AnnotationAssertion( "MA:0000067") +AnnotationAssertion( "MAT:0000037") +AnnotationAssertion( "MESH:D014680") +AnnotationAssertion( "MIAA:0000037") +AnnotationAssertion( "NCIT:C12814") +AnnotationAssertion( "SCTID:181367001") +AnnotationAssertion( "TAO:0000082") +AnnotationAssertion( "VHOG:0001743") +AnnotationAssertion( "Wikipedia:Vein") +AnnotationAssertion( "XAO:0000115") +AnnotationAssertion( "ZFA:0000082") +AnnotationAssertion( "galen:Vein") AnnotationAssertion(rdfs:label "vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepatic portal vein) + +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Hepatic_portal_vein") Annotation( "http://sourceforge.net/tracker/?func=detail&aid=3091300&group_id=76834&atid=1205376") "A portal vein that transports nutrients from the digestive tract to the liver[Kardong].") +AnnotationAssertion( "AAO:0010214") +AnnotationAssertion( "FMA:50735") +AnnotationAssertion( "MA:0002132") +AnnotationAssertion( "TAO:0005090") +AnnotationAssertion( "VHOG:0000642") +AnnotationAssertion( "Wikipedia:Hepatic_portal_vein") +AnnotationAssertion( "ZFA:0005090") +AnnotationAssertion(rdfs:label "hepatic portal vein") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (celiac artery) + +AnnotationAssertion(Annotation( "Wikipedia:Celiac_artery") "The first major branch of the abdominal aorta.") +AnnotationAssertion( "EHDAA2:0004519") +AnnotationAssertion( "EMAPA:35202") +AnnotationAssertion( "FMA:50737") +AnnotationAssertion( "GAID:483") +AnnotationAssertion( "MA:0001931") +AnnotationAssertion( "MESH:D002445") +AnnotationAssertion( "NCIT:C52846") +AnnotationAssertion( "SCTID:181340007") +AnnotationAssertion( "Wikipedia:Celiac_artery") +AnnotationAssertion(rdfs:comment "dorsal aorta in Kardong") +AnnotationAssertion(rdfs:label "celiac artery") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (trigeminal nerve) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0471209627") Annotation( "Wikipedia:Trigeminal_nerve") "Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw).") +AnnotationAssertion( "AAO:0010470") +AnnotationAssertion( "BAMS:5n") +AnnotationAssertion( "BAMS:Vn") +AnnotationAssertion( "BAMS:nV") +AnnotationAssertion( "BIRNLEX:869") +AnnotationAssertion( "BM:VN") +AnnotationAssertion( "BTO:0001072") +AnnotationAssertion( "EFO:0001402") +AnnotationAssertion( "EHDAA2:0002084") +AnnotationAssertion( "EHDAA:3738") +AnnotationAssertion( "EMAPA:17576") +AnnotationAssertion( "FMA:50866") +AnnotationAssertion( "GAID:726") +AnnotationAssertion( "MA:0001100") +AnnotationAssertion( "MBA:901") +AnnotationAssertion( "MESH:D014276") +AnnotationAssertion( "MFMO:0000093") +AnnotationAssertion( "NCIT:C12806") +AnnotationAssertion( "SCTID:362459002") +AnnotationAssertion( "TAO:0000697") +AnnotationAssertion( "VHOG:0000704") +AnnotationAssertion( "Wikipedia:Trigeminal_nerve") +AnnotationAssertion( "XAO:0003092") +AnnotationAssertion( "ZFA:0000697") AnnotationAssertion(rdfs:label "trigeminal nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31294,7 +45076,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right pulmonary artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "UBERON:cjm") "The pulmonary artery that supplies the right lung.") +AnnotationAssertion( "FMA:50872") +AnnotationAssertion( "MA:0002500") +AnnotationAssertion( "NCIT:C33489") +AnnotationAssertion( "SCTID:244235003") +AnnotationAssertion( "Wikipedia:Right_pulmonary_artery") +AnnotationAssertion( "galen:RightPulmonaryArtery") AnnotationAssertion(rdfs:label "right pulmonary artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31303,7 +45091,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left pulmonary artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "UBERON:cjm") "The pulmonary artery that supplies the left lung.") +AnnotationAssertion( "FMA:50873") +AnnotationAssertion( "MA:0002032") +AnnotationAssertion( "NCIT:C32971") +AnnotationAssertion( "SCTID:244234004") +AnnotationAssertion( "Wikipedia:Left_pulmonary_artery") +AnnotationAssertion( "galen:LeftPulmonaryArtery") AnnotationAssertion(rdfs:label "left pulmonary artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31312,7 +45106,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (facial vein) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Facial_vein") "The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted].") +AnnotationAssertion( "AAO:0010513") +AnnotationAssertion( "EMAPA:19220") +AnnotationAssertion( "FMA:50874") +AnnotationAssertion( "MA:0002115") +AnnotationAssertion( "NCIT:C32579") +AnnotationAssertion( "SCTID:181374006") +AnnotationAssertion( "Wikipedia:Facial_vein") AnnotationAssertion(rdfs:label "facial vein") SubClassOf( ) SubClassOf( ) @@ -31321,6 +45122,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trigeminal ganglion) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "http://www.ncbi.nlm.nih.gov/books/NBK53171") Annotation( "https://github.com/obophenotype/uberon/issues/693") "The cranial ganglion that is associated with and extends fibers into the trigeminal nerve.") +AnnotationAssertion( "AAO:0011107") +AnnotationAssertion( "BAMS:5Gn") +AnnotationAssertion( "BAMS:GV") +AnnotationAssertion( "BTO:0001231") +AnnotationAssertion( "EFO:0000903") +AnnotationAssertion( "EHDAA2:0002085") +AnnotationAssertion( "EHDAA:2113") +AnnotationAssertion( "EMAPA:16797") +AnnotationAssertion( "FMA:52618") +AnnotationAssertion( "GAID:725") +AnnotationAssertion( "MA:0001080") +AnnotationAssertion( "MAT:0000511") +AnnotationAssertion( "MESH:D012668") +AnnotationAssertion( "NCIT:C62642") +AnnotationAssertion( "SCTID:244449009") +AnnotationAssertion( "TAO:0000295") +AnnotationAssertion( "VHOG:0000694") +AnnotationAssertion( "Wikipedia:Trigeminal_ganglion") +AnnotationAssertion( "XAO:0000427") +AnnotationAssertion( "XAO:0000428") +AnnotationAssertion( "ZFA:0000295") +AnnotationAssertion( "neuronames:1402") AnnotationAssertion(rdfs:label "trigeminal ganglion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31331,7 +45155,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (occipital bone) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0005269") "The bone at the lower, posterior part of the skull.") +AnnotationAssertion( "EMAPA:25112") +AnnotationAssertion( "FMA:52735") +AnnotationAssertion( "GAID:227") +AnnotationAssertion( "MA:0001468") +AnnotationAssertion( "MESH:D009777") +AnnotationAssertion( "NCIT:C12757") +AnnotationAssertion( "SCTID:181796003") +AnnotationAssertion( "Wikipedia:Occipital_bone") AnnotationAssertion(rdfs:label "occipital bone") SubClassOf( ) SubClassOf( ) @@ -31342,9 +45174,84 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (sphenoid bone) + +AnnotationAssertion(Annotation( "Wikipedia:Sphenoid_bone") "An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended.") +AnnotationAssertion( "CALOHA:TS-2343") +AnnotationAssertion( "EMAPA:18340") +AnnotationAssertion( "FMA:52736") +AnnotationAssertion( "GAID:230") +AnnotationAssertion( "MA:0001472") +AnnotationAssertion( "MESH:D013100") +AnnotationAssertion( "NCIT:C12790") +AnnotationAssertion( "SCTID:272676008") +AnnotationAssertion( "Wikipedia:Sphenoid_bone") +AnnotationAssertion(rdfs:label "sphenoid bone") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (ethmoid bone) + +AnnotationAssertion(Annotation( "Wikipedia:Ethmoid_bone") "A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP].") +AnnotationAssertion( "BTO:0004140") +AnnotationAssertion( "EMAPA:19018") +AnnotationAssertion( "FMA:52740") +AnnotationAssertion( "GAID:212") +AnnotationAssertion( "MA:0001483") +AnnotationAssertion( "MESH:D005004") +AnnotationAssertion( "NCIT:C12711") +AnnotationAssertion( "SCTID:272674006") +AnnotationAssertion( "VHOG:0001317") +AnnotationAssertion( "Wikipedia:Ethmoid_bone") +AnnotationAssertion(rdfs:label "ethmoid bone") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (orbit of skull) + +AnnotationAssertion(Annotation( "TAO:0001410") Annotation( "Wikipedia:Orbit_(anatomy)") Annotation( "http://orcid.org/0000-0002-6601-2165") "Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball.") +AnnotationAssertion( "BTO:0004687") +AnnotationAssertion( "FMA:53074") +AnnotationAssertion( "GAID:223") +AnnotationAssertion( "MA:0002482") +AnnotationAssertion( "MESH:D009915") +AnnotationAssertion( "NCIT:C12347") +AnnotationAssertion( "TAO:0001410") +AnnotationAssertion( "Wikipedia:Orbit_(anatomy)") +AnnotationAssertion( "XAO:0003171") +AnnotationAssertion( "ZFA:0001410") +AnnotationAssertion( "galen:Orbit") +AnnotationAssertion(rdfs:label "orbit of skull") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (neurocranium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:11523816") Annotation( "TAO:MAH") Annotation( "Wikipedia:Neuroranium") Annotation( "ZFA:0001580") "Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof.") +AnnotationAssertion( "FMA:53672") +AnnotationAssertion( "MA:0000317") +AnnotationAssertion( "SCTID:361731002") +AnnotationAssertion( "TAO:0001580") +AnnotationAssertion( "Wikipedia:Neuroranium") +AnnotationAssertion( "XAO:0003170") +AnnotationAssertion( "ZFA:0001580") AnnotationAssertion(rdfs:label "neurocranium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31354,6 +45261,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (jaw skeleton) +AnnotationAssertion(Annotation( "Wikipedia:Jaw") Annotation( "https://orcid.org/0000-0002-6601-2165") "Subdivision of skeleton which includes upper and lower jaw skeletons.") +AnnotationAssertion( "AAO:0000988") +AnnotationAssertion( "BTO:0001749") +AnnotationAssertion( "EMAPA:35455") +AnnotationAssertion( "FMA:54396") +AnnotationAssertion( "GAID:214") +AnnotationAssertion( "MA:0001905") +AnnotationAssertion( "MESH:D007568") +AnnotationAssertion( "NCIT:C48821") +AnnotationAssertion( "SCTID:181811001") +AnnotationAssertion( "TAO:0001227") +AnnotationAssertion( "Wikipedia:Jaw") +AnnotationAssertion( "ZFA:0001227") +AnnotationAssertion( "galen:Jaw") AnnotationAssertion(rdfs:label "jaw skeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31365,8 +45286,44 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (upper jaw region) + +AnnotationAssertion(Annotation( "Wikipedia:Upper_jaw") Annotation( "http://orcid.org/0000-0002-6601-2165") "Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm].") +AnnotationAssertion( "AAO:0000620") +AnnotationAssertion( "EHDAA2:0002118") +AnnotationAssertion( "EHDAA2:0004607") +AnnotationAssertion( "EHDAA:8025") +AnnotationAssertion( "EMAPA:17924") +AnnotationAssertion( "FMA:59399") +AnnotationAssertion( "SCTID:362636001") +AnnotationAssertion( "VHOG:0000454") +AnnotationAssertion( "Wikipedia:Upper_jaw") +AnnotationAssertion( "ncithesaurus:Upper_Jaw") +AnnotationAssertion(rdfs:comment "See notes for jaw w.r.t skeletal element vs subdivision of head.") +AnnotationAssertion(rdfs:label "upper jaw region") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +DisjointClasses( ) + # Class: (lower jaw region) +AnnotationAssertion(Annotation( "Wikipedia:Lower_jaw") "Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm].") +AnnotationAssertion( "AAO:0000272") +AnnotationAssertion( "EFO:0003660") +AnnotationAssertion( "EHDAA2:0001018") +AnnotationAssertion( "EHDAA:7995") +AnnotationAssertion( "EMAPA:17906") +AnnotationAssertion( "FMA:59398") +AnnotationAssertion( "MESH:D008334") +AnnotationAssertion( "SCTID:362637005") +AnnotationAssertion( "VHOG:0000453") +AnnotationAssertion( "Wikipedia:Lower_jaw") +AnnotationAssertion( "ncithesaurus:Lower_Jaw") +AnnotationAssertion(rdfs:comment "See notes for jaw w.r.t skeletal element vs subdivision of head") AnnotationAssertion(rdfs:label "lower jaw region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31377,7 +45334,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranial ganglion) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MGI:csmith") Annotation( "MP:0001081") Annotation( "PMID:9362461") "The groups of nerve cell bodies associated with the twelve cranial nerves.") +AnnotationAssertion( "BIRNLEX:2597") +AnnotationAssertion( "BTO:0000106") +AnnotationAssertion( "EFO:0000902") +AnnotationAssertion( "EMAPA:16659") +AnnotationAssertion( "FMA:54502") +AnnotationAssertion( "MA:0000213") +AnnotationAssertion( "MA:0000214") +AnnotationAssertion( "MAT:0000200") +AnnotationAssertion( "MIAA:0000200") +AnnotationAssertion( "SCTID:244448001") +AnnotationAssertion( "TAO:0000013") +AnnotationAssertion( "VHOG:0000076") +AnnotationAssertion( "Wikipedia:Cranial_nerve_ganglion") +AnnotationAssertion( "XAO:0000027") +AnnotationAssertion( "ZFA:0000013") AnnotationAssertion(rdfs:label "cranial ganglion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31386,6 +45358,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cavity of pharynx) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that is enclosed by a pharynx.") +AnnotationAssertion( "AAO:0010435") +AnnotationAssertion( "BSA:0000113") +AnnotationAssertion( "BTO:0002097") +AnnotationAssertion( "EMAPA:18381") +AnnotationAssertion( "FMA:54935") +AnnotationAssertion( "SCTID:180543003") +AnnotationAssertion( "XAO:0000105") AnnotationAssertion(rdfs:label "cavity of pharynx") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31395,6 +45375,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anterior chamber of eyeball) +AnnotationAssertion(Annotation( "MESH:A09.371.060.067") Annotation( "MP:0005205") "The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens.") +AnnotationAssertion( "BTO:0002084") +AnnotationAssertion( "EHDAA2:0000129") +AnnotationAssertion( "EHDAA:9033") +AnnotationAssertion( "EMAPA:18231") +AnnotationAssertion( "FMA:58078") +AnnotationAssertion( "GAID:889") +AnnotationAssertion( "MA:0000262") +AnnotationAssertion( "MESH:D000867") +AnnotationAssertion( "NCIT:C12667") +AnnotationAssertion( "SCTID:181160009") +AnnotationAssertion( "VHOG:0001431") +AnnotationAssertion( "Wikipedia:Anterior_chamber_of_eyeball") AnnotationAssertion(rdfs:label "anterior chamber of eyeball") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31402,6 +45395,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (uvea) +AnnotationAssertion(Annotation( "MP:0005197") Annotation( "Wikipedia:Uvea") "The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited].") +AnnotationAssertion( "CALOHA:TS-2228") +AnnotationAssertion( "EMAPA:35901") +AnnotationAssertion( "FMA:58103") +AnnotationAssertion( "GAID:912") +AnnotationAssertion( "MA:0002480") +AnnotationAssertion( "MESH:D014602") +AnnotationAssertion( "NCIT:C12811") +AnnotationAssertion( "SCTID:280648000") +AnnotationAssertion( "Wikipedia:Uvea") AnnotationAssertion(rdfs:label "uvea") SubClassOf( ) SubClassOf( ) @@ -31414,7 +45417,24 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (iris) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0001322") "The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye.") +AnnotationAssertion( "AAO:0010347") +AnnotationAssertion( "BTO:0000653") +AnnotationAssertion( "CALOHA:TS-0491") +AnnotationAssertion( "EFO:0004245") +AnnotationAssertion( "EMAPA:19154") +AnnotationAssertion( "EV:0100345") +AnnotationAssertion( "FMA:58235") +AnnotationAssertion( "GAID:917") +AnnotationAssertion( "MA:0000273") +AnnotationAssertion( "MESH:D007498") +AnnotationAssertion( "NCIT:C12737") +AnnotationAssertion( "SCTID:181164000") +AnnotationAssertion( "TAO:0001238") +AnnotationAssertion( "VHOG:0000101") +AnnotationAssertion( "Wikipedia:Iris_(anatomy)") +AnnotationAssertion( "XAO:0000185") +AnnotationAssertion( "ZFA:0001238") AnnotationAssertion(rdfs:label "iris") SubClassOf( ) SubClassOf( ) @@ -31424,7 +45444,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (corneal epithelium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:A09.371.060.217.325") Annotation( "MGI:smb") Annotation( "MP:0006000") "The smooth stratified squamous epithelium that covers the outer surface of the cornea.") +AnnotationAssertion( "BTO:0000287") +AnnotationAssertion( "CALOHA:TS-0173") +AnnotationAssertion( "EFO:0001917") +AnnotationAssertion( "EHDAA2:0000319") +AnnotationAssertion( "EMAPA:17162") +AnnotationAssertion( "FMA:58263") +AnnotationAssertion( "GAID:895") +AnnotationAssertion( "MA:0001243") +AnnotationAssertion( "MESH:D019573") +AnnotationAssertion( "NCIT:C12928") +AnnotationAssertion( "SCTID:368825001") +AnnotationAssertion( "TAO:0002187") +AnnotationAssertion( "Wikipedia:Corneal_epithelium") +AnnotationAssertion( "ZFA:0001683") AnnotationAssertion(rdfs:label "corneal epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31435,7 +45469,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sclera) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Sclera") Annotation( "ZFIN:ZDB-PUB-050701-15") "Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP].") +AnnotationAssertion( "AAO:0010354") +AnnotationAssertion( "BTO:0001606") +AnnotationAssertion( "EMAPA:19027") +AnnotationAssertion( "EV:0100342") +AnnotationAssertion( "FMA:58269") +AnnotationAssertion( "GAID:911") +AnnotationAssertion( "MA:0000280") +AnnotationAssertion( "MESH:D012590") +AnnotationAssertion( "NCIT:C12784") +AnnotationAssertion( "SCTID:181163006") +AnnotationAssertion( "VHOG:0001274") +AnnotationAssertion( "Wikipedia:Sclera") +AnnotationAssertion( "XAO:0000183") +AnnotationAssertion( "ZFA:0005563") +AnnotationAssertion(rdfs:comment "Disease notes: implicated in rheumatoid arthritis.") AnnotationAssertion(rdfs:label "sclera") SubClassOf( ) SubClassOf( ) @@ -31447,6 +45496,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skeletal muscle of trunk) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A skeletal muscle organ that is part of the trunk region.") +AnnotationAssertion( "AAO:0000611") +AnnotationAssertion( "EMAPA:35888") +AnnotationAssertion( "FMA:58274") +AnnotationAssertion( "MA:0000514") +AnnotationAssertion( "TAO:0000473") +AnnotationAssertion( "XAO:0003230") +AnnotationAssertion( "ZFA:0000473") AnnotationAssertion(rdfs:label "skeletal muscle of trunk") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31455,7 +45512,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ciliary body) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0005099") Annotation( "Wikipedia:Ciliary_body") "The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes.") +AnnotationAssertion( "AAO:0010341") +AnnotationAssertion( "BTO:0000260") +AnnotationAssertion( "CALOHA:TS-0694") +AnnotationAssertion( "EMAPA:19065") +AnnotationAssertion( "EV:0100346") +AnnotationAssertion( "FMA:58295") +AnnotationAssertion( "GAID:916") +AnnotationAssertion( "MA:0000264") +AnnotationAssertion( "MESH:D002924") +AnnotationAssertion( "NCIT:C12345") +AnnotationAssertion( "SCTID:263340007") +AnnotationAssertion( "VHOG:0000102") +AnnotationAssertion( "Wikipedia:Ciliary_body") +AnnotationAssertion( "XAO:0000186") +AnnotationAssertion( "neuronames:1571") AnnotationAssertion(rdfs:label "ciliary body") SubClassOf( ) SubClassOf( ) @@ -31467,7 +45539,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (optic choroid) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Choroid") "Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP].") +AnnotationAssertion( "BTO:0001829") +AnnotationAssertion( "CALOHA:TS-2054") +AnnotationAssertion( "EMAPA:19077") +AnnotationAssertion( "EV:0100347") +AnnotationAssertion( "FMA:58298") +AnnotationAssertion( "GAID:913") +AnnotationAssertion( "MA:0000263") +AnnotationAssertion( "MESH:D002829") +AnnotationAssertion( "NCIT:C12344") +AnnotationAssertion( "SCTID:181172003") +AnnotationAssertion( "TAO:0005229") +AnnotationAssertion( "VHOG:0001568") +AnnotationAssertion( "Wikipedia:Choroid") +AnnotationAssertion( "ZFA:0005229") AnnotationAssertion(rdfs:label "optic choroid") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31480,6 +45566,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (substantia propria of cornea) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MESH:A09.371.060.217.228") Annotation( "MP:0005300") "The lamellated connective tissue of the cornea between the Bowman and Descemet membranes.") +AnnotationAssertion( "CALOHA:TS-1138") +AnnotationAssertion( "EFO:0002514") +AnnotationAssertion( "EMAPA:17602") +AnnotationAssertion( "FMA:58306") +AnnotationAssertion( "GAID:893") +AnnotationAssertion( "MA:0001245") +AnnotationAssertion( "MESH:D003319") +AnnotationAssertion( "NCIT:C12699") +AnnotationAssertion( "SCTID:362511000") +AnnotationAssertion( "TAO:0002189") +AnnotationAssertion( "Wikipedia:Corneal_stroma") +AnnotationAssertion( "ZFA:0001685") AnnotationAssertion(rdfs:label "substantia propria of cornea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31492,7 +45591,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ciliary epithelium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Ciliary_body#Ciliary_epithelium") "A double layer covering the ciliary body that produces aqueous humor.") +AnnotationAssertion( "BTO:0001770") +AnnotationAssertion( "CALOHA:TS-0695") +AnnotationAssertion( "EMAPA:35239") +AnnotationAssertion( "FMA:58464") +AnnotationAssertion( "MA:0001238") +AnnotationAssertion( "NCIT:C32314") +AnnotationAssertion( "SCTID:280870004") +AnnotationAssertion( "Wikipedia:Ciliary_body#Ciliary_epithelium") AnnotationAssertion(rdfs:label "ciliary epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31503,6 +45610,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (iris stroma) +AnnotationAssertion(Annotation( "Wikipedia:Iris_stroma") Annotation( "http://www.drugs.com/dict/stroma-of-iris.html") "The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae.") +AnnotationAssertion( "EMAPA:35451") +AnnotationAssertion( "FMA:58526") +AnnotationAssertion( "MA:0002777") +AnnotationAssertion( "SCTID:280882008") +AnnotationAssertion( "Wikipedia:Iris_stroma") +AnnotationAssertion( "ZFA:0005569") AnnotationAssertion(rdfs:label "iris stroma") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31512,7 +45626,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (spinal nerve) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:A08.800.800.720") Annotation( "MP:0001077") "The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified].") +AnnotationAssertion( "AAO:0011101") +AnnotationAssertion( "BAMS:spin") +AnnotationAssertion( "BTO:0000870") +AnnotationAssertion( "EHDAA2:0001898") +AnnotationAssertion( "EMAPA:16989") +AnnotationAssertion( "FMA:5858") +AnnotationAssertion( "GAID:841") +AnnotationAssertion( "MA:0000233") +AnnotationAssertion( "MESH:D013127") +AnnotationAssertion( "NCIT:C12792") +AnnotationAssertion( "SCTID:361099009") +AnnotationAssertion( "VHOG:0000824") +AnnotationAssertion( "Wikipedia:Spinal_nerve") +AnnotationAssertion( "XAO:0003101") +AnnotationAssertion( "neuronames:1228") AnnotationAssertion(rdfs:label "spinal nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31520,6 +45649,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (layer of retina) +AnnotationAssertion(Annotation( "MP:0003727") "Any of the layers that make up the retina[MP].") +AnnotationAssertion( "AAO:0010353") +AnnotationAssertion( "EMAPA:35742") +AnnotationAssertion( "FMA:58617") +AnnotationAssertion( "MA:0001319") +AnnotationAssertion( "NCIT:C49328") +AnnotationAssertion( "SCTID:280657006") +AnnotationAssertion( "XAO:0000266") AnnotationAssertion(rdfs:label "layer of retina") SubClassOf( ) SubClassOf( ) @@ -31528,7 +45665,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranial nerve) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Cranial_nerve") "Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord.") +AnnotationAssertion( "AAO:0000108") +AnnotationAssertion( "BAMS:cran") +AnnotationAssertion( "BIRNLEX:1623") +AnnotationAssertion( "BTO:0001104") +AnnotationAssertion( "EHDAA2:0000323") +AnnotationAssertion( "EMAPA:17264") +AnnotationAssertion( "FMA:5865") +AnnotationAssertion( "GAID:802") +AnnotationAssertion( "MA:0000215") +AnnotationAssertion( "MBA:967") +AnnotationAssertion( "MESH:D003391") +AnnotationAssertion( "NCIT:C12700") +AnnotationAssertion( "SCTID:244447006") +AnnotationAssertion( "TAO:0000641") +AnnotationAssertion( "VHOG:0000279") +AnnotationAssertion( "Wikipedia:Cranial_nerve") +AnnotationAssertion( "XAO:0000429") +AnnotationAssertion( "XAO:0003089") +AnnotationAssertion( "ZFA:0000641") +AnnotationAssertion( "neuronames:1227") AnnotationAssertion(rdfs:label "cranial nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31538,6 +45695,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aqueous humor of eyeball) +AnnotationAssertion(Annotation( "Wikipedia:Aqueous_humor") "A thick watery refractive medium that fills the space between the lens and the cornea[WP].") +AnnotationAssertion( "EHDAA2:0000139") +AnnotationAssertion( "EHDAA:10196") +AnnotationAssertion( "EMAPA:18232") +AnnotationAssertion( "ENVO:02000024") +AnnotationAssertion( "FMA:58819") +AnnotationAssertion( "GAID:890") +AnnotationAssertion( "MA:0001236") +AnnotationAssertion( "MESH:D001082") +AnnotationAssertion( "NCIT:C13190") +AnnotationAssertion( "SCTID:280587006") +AnnotationAssertion( "VHOG:0000548") +AnnotationAssertion( "Wikipedia:Aqueous_humor") +AnnotationAssertion( "ZFA:0005564") AnnotationAssertion(rdfs:label "aqueous humor of eyeball") SubClassOf( ) SubClassOf( ) @@ -31546,7 +45717,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sensory ganglion) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MP:0000960") "The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells.") +AnnotationAssertion( "AEO:0001000") +AnnotationAssertion( "BTO:0005630") +AnnotationAssertion( "EMAPA:36596") +AnnotationAssertion( "FMA:5885") +AnnotationAssertion( "MA:0002566") +AnnotationAssertion( "MESH:D017950") +AnnotationAssertion( "NCIT:C13060") AnnotationAssertion(rdfs:label "sensory ganglion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31554,6 +45732,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anterior segment of eyeball) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MESH:A09.371.060") Annotation( "MP:0005193") "Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive).") +AnnotationAssertion( "EMAPA:36594") +AnnotationAssertion( "FMA:58865") +AnnotationAssertion( "MA:0002484") +AnnotationAssertion( "MESH:D000869") +AnnotationAssertion( "NCIT:C12668") +AnnotationAssertion( "SCTID:280658001") +AnnotationAssertion( "Wikipedia:Anterior_segment_of_eyeball") +AnnotationAssertion( "ZFA:0005566") AnnotationAssertion(rdfs:label "anterior segment of eyeball") SubClassOf( ) SubClassOf( ) @@ -31563,6 +45750,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (posterior segment of eyeball) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0005195") "Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive).") +AnnotationAssertion( "EMAPA:36595") +AnnotationAssertion( "FMA:58868") +AnnotationAssertion( "MA:0002485") +AnnotationAssertion( "NCIT:C12906") +AnnotationAssertion( "SCTID:280659009") +AnnotationAssertion( "Wikipedia:Posterior_segment_of_eyeball") +AnnotationAssertion( "ZFA:0005567") AnnotationAssertion(rdfs:label "posterior segment of eyeball") SubClassOf( ) SubClassOf( ) @@ -31572,7 +45767,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelium of lens) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A layer of epithelial cells that is part of the eye.") +AnnotationAssertion( "BTO:0001873") +AnnotationAssertion( "CALOHA:TS-0543") +AnnotationAssertion( "EMAPA:32871") +AnnotationAssertion( "FMA:58871") +AnnotationAssertion( "MA:0001301") +AnnotationAssertion( "SCTID:362523006") +AnnotationAssertion( "TAO:0001326") +AnnotationAssertion( "Wikipedia:Lens_(anatomy)#Lens_Epithelium") +AnnotationAssertion( "XAO:0004094") +AnnotationAssertion( "ZFA:0001326") AnnotationAssertion(rdfs:label "epithelium of lens") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31582,6 +45787,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (capsule of lens) +AnnotationAssertion(Annotation( "MGI:smb") Annotation( "MP:0003236") Annotation( "PMID:15483628") "The elastic, clear, membrane-like structure, that is outer most layer of the lens.") +AnnotationAssertion( "EHDAA2:0000977") +AnnotationAssertion( "EMAPA:18237") +AnnotationAssertion( "FMA:58881") +AnnotationAssertion( "MA:0001300") +AnnotationAssertion( "NCIT:C32975") +AnnotationAssertion( "SCTID:244500004") +AnnotationAssertion( "VHOG:0000550") +AnnotationAssertion( "Wikipedia:Lens_(anatomy)#Lens_capsule") +AnnotationAssertion( "ZFA:0005574") AnnotationAssertion(rdfs:label "capsule of lens") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31594,7 +45809,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (autonomic ganglion) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Autonomic_ganglion") "Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion.") +AnnotationAssertion( "AEO:0001001") +AnnotationAssertion( "CALOHA:TS-2340") +AnnotationAssertion( "EMAPA:18221") +AnnotationAssertion( "FMA:5889") +AnnotationAssertion( "MA:0000220") +AnnotationAssertion( "MESH:D005725") +AnnotationAssertion( "NCIT:C12720") +AnnotationAssertion( "Wikipedia:Autonomic_ganglion") AnnotationAssertion(rdfs:label "autonomic ganglion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31603,6 +45826,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sympathetic ganglion) +AnnotationAssertion(Annotation( "MP:0001008") Annotation( "http://orcid.org/0000-0002-6601-2165") "A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.") +AnnotationAssertion( "AAO:0010773") +AnnotationAssertion( "BTO:0001333") +AnnotationAssertion( "CALOHA:TS-0994") +AnnotationAssertion( "EHDAA2:0001969") +AnnotationAssertion( "EMAPA:17157") +AnnotationAssertion( "FMA:5890") +AnnotationAssertion( "MA:0000226") +AnnotationAssertion( "NCIT:C12467") +AnnotationAssertion( "SCTID:362485003") +AnnotationAssertion( "Wikipedia:Sympathetic_ganglion") AnnotationAssertion(rdfs:label "sympathetic ganglion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31614,14 +45848,55 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lip) +AnnotationAssertion(Annotation( "Wikipedia:Lip") Annotation( "http://www.medterms.com/script/main/art.asp?articlekey=9458") "One of the two fleshy folds which surround the opening of the mouth.") +AnnotationAssertion( "BTO:0001647") +AnnotationAssertion( "CALOHA:TS-0558") +AnnotationAssertion( "EMAPA:32839") +AnnotationAssertion( "FMA:59816") +AnnotationAssertion( "GAID:76") +AnnotationAssertion( "MA:0000343") +AnnotationAssertion( "MESH:D008046") +AnnotationAssertion( "NCIT:C12220") +AnnotationAssertion( "SCTID:181221003") +AnnotationAssertion( "TAO:0007006") +AnnotationAssertion( "VHOG:0000677") +AnnotationAssertion( "Wikipedia:Lip") +AnnotationAssertion( "ZFA:0007006") +AnnotationAssertion( "galen:Lip") AnnotationAssertion(rdfs:label "lip") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (upper lip) + +AnnotationAssertion(Annotation( "TAO:0001970") Annotation( "Wikipedia:Upper_lip") "Lip that covers the upper portion of the mouth.[TAO].") +AnnotationAssertion( "EMAPA:17925") +AnnotationAssertion( "FMA:59817") +AnnotationAssertion( "MA:0000919") +AnnotationAssertion( "SCTID:245776003") +AnnotationAssertion( "TAO:0001970") +AnnotationAssertion( "VHOG:0001750") +AnnotationAssertion( "Wikipedia:Upper_lip") +AnnotationAssertion( "ZFA:0005226") +AnnotationAssertion(rdfs:label "upper lip") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (lower lip) +AnnotationAssertion(Annotation( "TAO:0002060") Annotation( "Wikipedia:Lower_lip") "Lip that covers the lower portion of the mouth.[TAO].") +AnnotationAssertion( "EMAPA:17909") +AnnotationAssertion( "FMA:59818") +AnnotationAssertion( "MA:0000921") +AnnotationAssertion( "NCIT:C94572") +AnnotationAssertion( "SCTID:245777007") +AnnotationAssertion( "TAO:0002060") +AnnotationAssertion( "Wikipedia:Lower_lip") +AnnotationAssertion( "ZFA:0005225") AnnotationAssertion(rdfs:label "lower lip") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31630,7 +45905,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (phrenic nerve) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "VHOG:0000728") "A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium.") +AnnotationAssertion( "BAMS:phn") +AnnotationAssertion( "BTO:0001063") +AnnotationAssertion( "EHDAA:4677") +AnnotationAssertion( "EMAPA:17813") +AnnotationAssertion( "FMA:6191") +AnnotationAssertion( "GAID:848") +AnnotationAssertion( "MA:0001170") +AnnotationAssertion( "MESH:D010791") +AnnotationAssertion( "NCIT:C52813") +AnnotationAssertion( "SCTID:280344009") +AnnotationAssertion( "VHOG:0000728") +AnnotationAssertion( "Wikipedia:Phrenic_nerve") AnnotationAssertion(rdfs:label "phrenic nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31639,7 +45926,35 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (midbrain) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0030901") "The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO].") +AnnotationAssertion( "AAO:0010149") +AnnotationAssertion( "BAMS:MES") +AnnotationAssertion( "BIRNLEX:1667") +AnnotationAssertion( "BM:MB") +AnnotationAssertion( "BTO:0000138") +AnnotationAssertion( "CALOHA:TS-0630") +AnnotationAssertion( "DHBA:10648") +AnnotationAssertion( "DMBA:16649") +AnnotationAssertion( "EFO:0000919") +AnnotationAssertion( "EHDAA2:0001162") +AnnotationAssertion( "EHDAA:3694") +AnnotationAssertion( "EMAPA:16974") +AnnotationAssertion( "EV:0100242") +AnnotationAssertion( "FMA:61993") +AnnotationAssertion( "HBA:9001") +AnnotationAssertion( "MA:0000207") +AnnotationAssertion( "MAT:0000106") +AnnotationAssertion( "MBA:313") +AnnotationAssertion( "MESH:D008636") +AnnotationAssertion( "MIAA:0000106") +AnnotationAssertion( "NCIT:C12510") +AnnotationAssertion( "RETIRED_EHDAA2:0001104") +AnnotationAssertion( "SCTID:279099009") +AnnotationAssertion( "TAO:0000128") +AnnotationAssertion( "VHOG:0000069") +AnnotationAssertion( "Wikipedia:Midbrain") +AnnotationAssertion( "XAO:0000014") +AnnotationAssertion( "ZFA:0000128") AnnotationAssertion(rdfs:label "midbrain") SubClassOf( ) SubClassOf( ) @@ -31649,6 +45964,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (rhombomere) +AnnotationAssertion(Annotation( "Wikipedia:Rhombomere") Annotation( "ZFIN:curator") "A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP].") +AnnotationAssertion( "DHBA:12664") +AnnotationAssertion( "EFO:0003617") +AnnotationAssertion( "EMAPA:16148") +AnnotationAssertion( "FMA:295666") +AnnotationAssertion( "MAT:0000272") +AnnotationAssertion( "MIAA:0000272") +AnnotationAssertion( "RETIRED_EHDAA2:0000669") +AnnotationAssertion( "TAO:0001064") +AnnotationAssertion( "VHOG:0000672") +AnnotationAssertion( "Wikipedia:Rhombomere") +AnnotationAssertion( "XAO:0004079") +AnnotationAssertion( "ZFA:0001064") AnnotationAssertion(rdfs:label "rhombomere") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31656,6 +45984,24 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (metencephalon) +AnnotationAssertion(Annotation( "Wikipedia:Metencephalon") Annotation( "https://github.com/obophenotype/uberon/issues/300") "Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified].") +AnnotationAssertion( "BAMS:Met") +AnnotationAssertion( "BIRNLEX:965") +AnnotationAssertion( "BTO:0000673") +AnnotationAssertion( "CALOHA:TS-2029") +AnnotationAssertion( "DHBA:10655") +AnnotationAssertion( "EHDAA2:0001149") +AnnotationAssertion( "EHDAA:5498") +AnnotationAssertion( "EMAPA:17071") +AnnotationAssertion( "FMA:62003") +AnnotationAssertion( "GAID:594") +AnnotationAssertion( "HBA:4833") +AnnotationAssertion( "MA:0000197") +AnnotationAssertion( "MESH:D020540") +AnnotationAssertion( "NCIT:C32741") +AnnotationAssertion( "VHOG:0000741") +AnnotationAssertion( "Wikipedia:Metencephalon") +AnnotationAssertion(rdfs:comment "the terms metencephalon and myelencephalon are only meaningful in mammals and birds[Neuroanatomy of the Zebrafish Brain]. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished in ZFA[ZFA].") AnnotationAssertion(rdfs:label "metencephalon") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31663,7 +46009,35 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (medulla oblongata) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FMA:62004") Annotation( "GO:0021550") Annotation( "Wikipedia:Bone_marrow_of_ovary_oblongata") "Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO].") +AnnotationAssertion( "AAO:0010486") +AnnotationAssertion( "BAMS:MY") +AnnotationAssertion( "BAMS:Md") +AnnotationAssertion( "BIRNLEX:957") +AnnotationAssertion( "BM:Me") +AnnotationAssertion( "BTO:0000041") +AnnotationAssertion( "CALOHA:TS-0607") +AnnotationAssertion( "DMBA:17352") +AnnotationAssertion( "EFO:0000924") +AnnotationAssertion( "EHDAA2:0001088") +AnnotationAssertion( "EHDAA:7588") +AnnotationAssertion( "EMAPA:17550") +AnnotationAssertion( "EV:0100275") +AnnotationAssertion( "FMA:62004") +AnnotationAssertion( "GAID:590") +AnnotationAssertion( "MA:0000206") +AnnotationAssertion( "MAT:0000111") +AnnotationAssertion( "MAT:0000367") +AnnotationAssertion( "MBA:354") +AnnotationAssertion( "MESH:D008526") +AnnotationAssertion( "MIAA:0000111") +AnnotationAssertion( "NCIT:C12442") +AnnotationAssertion( "SCTID:279104005") +AnnotationAssertion( "TAO:0000545") +AnnotationAssertion( "VHOG:0000181") +AnnotationAssertion( "Wikipedia:Bone_marrow_of_ovary_oblongata") +AnnotationAssertion( "XAO:0003100") +AnnotationAssertion( "ZFA:0000545") AnnotationAssertion(rdfs:label "medulla oblongata") SubClassOf( ) SubClassOf( ) @@ -31675,7 +46049,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelium of trachea) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-397-51047-0") Annotation( "MGI:cwg") Annotation( "MP:0002285") "The epithelial lining of the trachea which contains numerous ciliated cells.") +AnnotationAssertion( "BTO:0001389") +AnnotationAssertion( "CALOHA:TS-1061") +AnnotationAssertion( "EHDAA2:0002069") +AnnotationAssertion( "EHDAA:5007") +AnnotationAssertion( "EMAPA:16855") +AnnotationAssertion( "EMAPA:18409") +AnnotationAssertion( "FMA:62015") +AnnotationAssertion( "MA:0001862") +AnnotationAssertion( "NCIT:C33797") +AnnotationAssertion( "VHOG:0001045") AnnotationAssertion(rdfs:label "epithelium of trachea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31683,8 +46067,32 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelium of small intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a small intestine [Automatically generated definition].") +AnnotationAssertion( "BTO:0001258") +AnnotationAssertion( "CALOHA:TS-2104") +AnnotationAssertion( "EMAPA:35778") +AnnotationAssertion( "FMA:62017") +AnnotationAssertion( "MA:0001553") +AnnotationAssertion( "SCTID:45480009") +AnnotationAssertion( "TAO:0005127") +AnnotationAssertion( "ZFA:0005127") +AnnotationAssertion(rdfs:label "epithelium of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (endothelium of capillary) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of a capillary [Automatically generated definition].") +AnnotationAssertion( "BTO:0004954") +AnnotationAssertion( "CALOHA:TS-0112") +AnnotationAssertion( "EMAPA:36292") +AnnotationAssertion( "FMA:62114") +AnnotationAssertion( "MA:0000711") +AnnotationAssertion( "NCIT:C49215") AnnotationAssertion(rdfs:label "endothelium of capillary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31692,6 +46100,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endothelium of arteriole) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of an arteriole [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36286") +AnnotationAssertion( "FMA:62115") +AnnotationAssertion( "MA:0000705") +AnnotationAssertion( "NCIT:C49192") AnnotationAssertion(rdfs:label "endothelium of arteriole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31700,6 +46113,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endothelium of artery) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of an artery [Automatically generated definition].") +AnnotationAssertion( "AAO:0011013") +AnnotationAssertion( "BTO:0004757") +AnnotationAssertion( "EMAPA:35148") +AnnotationAssertion( "FMA:62116") +AnnotationAssertion( "MA:0000707") +AnnotationAssertion( "NCIT:C49194") +AnnotationAssertion( "VHOG:0001215") +AnnotationAssertion( "XAO:0000357") AnnotationAssertion(rdfs:label "endothelium of artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31709,6 +46131,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endothelium of venule) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of a venule [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36290") +AnnotationAssertion( "FMA:62117") +AnnotationAssertion( "MA:0000716") +AnnotationAssertion( "NCIT:C49319") AnnotationAssertion(rdfs:label "endothelium of venule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31717,6 +46144,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endothelium of vein) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of a vein [Automatically generated definition].") +AnnotationAssertion( "AAO:0011110") +AnnotationAssertion( "BTO:0004756") +AnnotationAssertion( "EMAPA:36288") +AnnotationAssertion( "FMA:62118") +AnnotationAssertion( "MA:0000712") +AnnotationAssertion( "NCIT:C49317") +AnnotationAssertion( "VHOG:0001216") +AnnotationAssertion( "XAO:0000358") AnnotationAssertion(rdfs:label "endothelium of vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31725,7 +46161,25 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (midbrain tegmentum) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FMA:FMA") Annotation( "ISBN:0471888893") Annotation( "Wikipedia:Midbrain_tegmentum") "Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP].") +AnnotationAssertion( "BAMS:MTg") +AnnotationAssertion( "BIRNLEX:1200") +AnnotationAssertion( "BTO:0003388") +AnnotationAssertion( "DHBA:12195") +AnnotationAssertion( "EFO:0000921") +AnnotationAssertion( "EHDAA2:0004475") +AnnotationAssertion( "EMAPA:18215") +AnnotationAssertion( "FMA:62393") +AnnotationAssertion( "HBA:9002") +AnnotationAssertion( "MA:0000212") +AnnotationAssertion( "MAT:0000452") +AnnotationAssertion( "SCTID:362392007") +AnnotationAssertion( "TAO:0000160") +AnnotationAssertion( "VHOG:0001367") +AnnotationAssertion( "Wikipedia:Midbrain_tegmentum") +AnnotationAssertion( "XAO:0004271") +AnnotationAssertion( "ZFA:0000160") +AnnotationAssertion(rdfs:comment "'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum") AnnotationAssertion(rdfs:label "midbrain tegmentum") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31734,6 +46188,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (regional part of spinal cord) +AnnotationAssertion(Annotation( "OBOL:automatic") "A multi-tissue structure that is part of a spinal cord.") +AnnotationAssertion( "BIRNLEX:1496") +AnnotationAssertion( "NCIT:C33969") +AnnotationAssertion( "SCTID:244437008") AnnotationAssertion(rdfs:label "regional part of spinal cord") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31742,7 +46200,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelium of respiratory bronchiole) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a respiratory bronchiole [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35730") +AnnotationAssertion( "FMA:62498") +AnnotationAssertion( "MA:0001773") +AnnotationAssertion( "NCIT:C48943") AnnotationAssertion(rdfs:label "epithelium of respiratory bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31750,7 +46212,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cartilage of bronchus) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MP:0010988") "The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP].") +AnnotationAssertion( "EMAPA:35192") +AnnotationAssertion( "FMA:62649") +AnnotationAssertion( "MA:0001835") +AnnotationAssertion( "NCIT:C49209") +AnnotationAssertion( "SCTID:278980009") AnnotationAssertion(rdfs:label "cartilage of bronchus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31761,6 +46228,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (submucosa of bronchus) +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a bronchus [Automatically generated definition].") +AnnotationAssertion( "BTO:0002108") +AnnotationAssertion( "FMA:62653") +AnnotationAssertion( "MA:0001837") +AnnotationAssertion( "NCIT:C49214") +AnnotationAssertion( "SCTID:85546005") AnnotationAssertion(rdfs:label "submucosa of bronchus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31769,7 +46242,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (terminal bronchiole epithelium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An epithelium that lines a terminal bronchiole.") +AnnotationAssertion( "EMAPA:36283") +AnnotationAssertion( "FMA:62794") +AnnotationAssertion( "MA:0001774") +AnnotationAssertion( "NCIT:C33755") AnnotationAssertion(rdfs:label "terminal bronchiole epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31777,6 +46254,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (blood plasma) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The liquid component of blood, in which erythrocytes are suspended.") +AnnotationAssertion( "BTO:0000131") +AnnotationAssertion( "CALOHA:TS-0800") +AnnotationAssertion( "EFO:0001905") +AnnotationAssertion( "EMAPA:35690") +AnnotationAssertion( "FMA:62970") +AnnotationAssertion( "GAID:1178") +AnnotationAssertion( "MA:0002501") +AnnotationAssertion( "MAT:0000052") +AnnotationAssertion( "MESH:D010949") +AnnotationAssertion( "MIAA:0000052") +AnnotationAssertion( "NCIT:C13356") +AnnotationAssertion( "Wikipedia:Blood_plasma") AnnotationAssertion(rdfs:label "blood plasma") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31784,8 +46274,41 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (bile) + +AnnotationAssertion(Annotation( "DOI:10.1002/cphy.c120027") Annotation( "Wikipedia:Bile") "Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium.") +AnnotationAssertion( "BTO:0000121") +AnnotationAssertion( "CALOHA:TS-1172") +AnnotationAssertion( "ENVO:02000023") +AnnotationAssertion( "FMA:62971") +AnnotationAssertion( "GAID:1157") +AnnotationAssertion( "MA:0002513") +AnnotationAssertion( "MESH:D001646") +AnnotationAssertion( "NCIT:C13192") +AnnotationAssertion( "Wikipedia:Bile") +AnnotationAssertion( "ZFA:0005857") +AnnotationAssertion( "galen:Bile") +AnnotationAssertion(rdfs:label "bile") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (gastric juice) +AnnotationAssertion( "BTO:0000501") +AnnotationAssertion( "FMA:62972") +AnnotationAssertion( "GAID:1160") +AnnotationAssertion( "MA:0002519") +AnnotationAssertion( "MESH:D005750") +AnnotationAssertion( "NCIT:C32661") +AnnotationAssertion( "Wikipedia:Gastric_juice") +AnnotationAssertion( "galen:GastricJuice") AnnotationAssertion(rdfs:label "gastric juice") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31793,6 +46316,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (submucosa of esophagus) +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a esophagus [Automatically generated definition].") +AnnotationAssertion( "BTO:0002109") +AnnotationAssertion( "EMAPA:35325") +AnnotationAssertion( "FMA:62997") +AnnotationAssertion( "MA:0002724") +AnnotationAssertion( "SCTID:362128009") AnnotationAssertion(rdfs:label "submucosa of esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31800,6 +46329,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lamina propria of esophagus) +AnnotationAssertion(Annotation( "OBOL:automatic") "A lamina propria that is part of a esophagus [Automatically generated definition].") +AnnotationAssertion( "EMAPA:26987") +AnnotationAssertion( "FMA:63050") +AnnotationAssertion( "MA:0001568") +AnnotationAssertion( "NCIT:C49223") AnnotationAssertion(rdfs:label "lamina propria of esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31807,6 +46341,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (serosa of esophagus) +AnnotationAssertion(Annotation( "OBOL:automatic") "A serous membrane that is part of a esophagus [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35322") +AnnotationAssertion( "FMA:63057") +AnnotationAssertion( "MA:0001571") AnnotationAssertion(rdfs:label "serosa of esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31814,6 +46352,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelium of esophagus) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0000468") "The epithelial layer that lines the luminal space of the esophagus.") +AnnotationAssertion( "BTO:0001578") +AnnotationAssertion( "CALOHA:TS-0698") +AnnotationAssertion( "EFO:0003041") +AnnotationAssertion( "EHDAA2:0001287") +AnnotationAssertion( "EMAPA:16835") +AnnotationAssertion( "FMA:63063") +AnnotationAssertion( "MA:0001565") +AnnotationAssertion( "NCIT:C49221") +AnnotationAssertion( "TAO:0001499") +AnnotationAssertion( "ZFA:0001499") AnnotationAssertion(rdfs:label "epithelium of esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31821,9 +46370,32 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (parenchyma of pancreas) + +AnnotationAssertion( "EMAPA:32925") +AnnotationAssertion( "FMA:63120") +AnnotationAssertion( "MA:0000724") +AnnotationAssertion( "SCTID:371401008") +AnnotationAssertion( "VHOG:0001430") +AnnotationAssertion(rdfs:label "parenchyma of pancreas") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (venule) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:A07.231.432.952") Annotation( "MP:0004125") "One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins.") +AnnotationAssertion( "BTO:0002626") +AnnotationAssertion( "EMAPA:35917") +AnnotationAssertion( "FMA:63130") +AnnotationAssertion( "MA:0000071") +AnnotationAssertion( "MESH:D014699") +AnnotationAssertion( "NCIT:C12818") +AnnotationAssertion( "SCTID:341687009") +AnnotationAssertion( "TAO:0005315") +AnnotationAssertion( "VHOG:0001765") +AnnotationAssertion( "Wikipedia:Venule") +AnnotationAssertion( "ZFA:0005315") AnnotationAssertion(rdfs:label "venule") SubClassOf( ) SubClassOf( ) @@ -31832,6 +46404,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (arteriole) +AnnotationAssertion(Annotation( "GO:0014830") "The smallest division of the artery located between the muscular arteries and the capillaries[GO].") +AnnotationAssertion( "AAO:0010253") +AnnotationAssertion( "BTO:0001997") +AnnotationAssertion( "EMAPA:35146") +AnnotationAssertion( "FMA:63182") +AnnotationAssertion( "MA:0000063") +AnnotationAssertion( "MESH:D001160") +AnnotationAssertion( "NCIT:C12672") +AnnotationAssertion( "SCTID:337724002") +AnnotationAssertion( "TAO:0002138") +AnnotationAssertion( "VHOG:0001763") +AnnotationAssertion( "Wikipedia:Arteriole") +AnnotationAssertion( "ZFA:0005255") AnnotationAssertion(rdfs:label "arteriole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31842,7 +46427,30 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (blood vessel) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "BTO:0001102") Annotation( "Wikipedia:Blood_vessel") "A vessel through which blood circulates in the body.") +AnnotationAssertion( "AAO:0011004") +AnnotationAssertion( "AEO:0000207") +AnnotationAssertion( "BTO:0001102") +AnnotationAssertion( "CALOHA:TS-0080") +AnnotationAssertion( "EFO:0000817") +AnnotationAssertion( "EHDAA2:0003252") +AnnotationAssertion( "EHDAA:240") +AnnotationAssertion( "EMAPA:32743") +AnnotationAssertion( "EMAPA:35993") +AnnotationAssertion( "FMA:50722") +AnnotationAssertion( "FMA:63183") +AnnotationAssertion( "GAID:169") +AnnotationAssertion( "MA:0000060") +AnnotationAssertion( "MAT:0000393") +AnnotationAssertion( "MESH:D001808") +AnnotationAssertion( "NCIT:C12679") +AnnotationAssertion( "NLXANAT:090901") +AnnotationAssertion( "SCTID:361097006") +AnnotationAssertion( "TAO:0002137") +AnnotationAssertion( "VHOG:0001250") +AnnotationAssertion( "Wikipedia:Blood_vessel") +AnnotationAssertion( "XAO:0001011") +AnnotationAssertion( "ZFA:0005314") AnnotationAssertion(rdfs:label "blood vessel") SubClassOf( ) SubClassOf( ) @@ -31857,7 +46465,23 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (capillary) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Capillary") Annotation( "https://github.com/obophenotype/uberon/issues/137") "Any of the smallest blood vessels connecting arterioles with venules.") +AnnotationAssertion( "AAO:0010252") +AnnotationAssertion( "BTO:0002045") +AnnotationAssertion( "CALOHA:TS-2006") +AnnotationAssertion( "EFO:0001906") +AnnotationAssertion( "EMAPA:35198") +AnnotationAssertion( "EV:0100035") +AnnotationAssertion( "FMA:63194") +AnnotationAssertion( "MA:0000065") +AnnotationAssertion( "MESH:D002196") +AnnotationAssertion( "NCIT:C12685") +AnnotationAssertion( "NLXANAT:090902") +AnnotationAssertion( "TAO:0005250") +AnnotationAssertion( "VHOG:0001253") +AnnotationAssertion( "Wikipedia:Capillary") +AnnotationAssertion( "XAO:0000116") +AnnotationAssertion( "ZFA:0005250") AnnotationAssertion(rdfs:label "capillary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31866,7 +46490,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (corneal endothelium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Corneal_endothelium") "A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP].") +AnnotationAssertion( "CALOHA:TS-0172") +AnnotationAssertion( "EMAPA:35935") +AnnotationAssertion( "FMA:63882") +AnnotationAssertion( "GAID:891") +AnnotationAssertion( "MA:0001242") +AnnotationAssertion( "MESH:D004728") +AnnotationAssertion( "NCIT:C12707") +AnnotationAssertion( "SCTID:368827009") +AnnotationAssertion( "TAO:0002186") +AnnotationAssertion( "Wikipedia:Corneal_endothelium") +AnnotationAssertion( "ZFA:0001687") AnnotationAssertion(rdfs:label "corneal endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31878,7 +46513,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endothelium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FMA:63916") Annotation( "MESH:A10.272.491") Annotation( "https://github.com/obophenotype/uberon/issues/225") "A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA].") +AnnotationAssertion( "BTO:0000393") +AnnotationAssertion( "CALOHA:TS-0278") +AnnotationAssertion( "EFO:0002548") +AnnotationAssertion( "FMA:63916") +AnnotationAssertion( "GAID:520") +AnnotationAssertion( "MESH:D004727") +AnnotationAssertion( "NCIT:C12481") +AnnotationAssertion( "SCTID:27168002") +AnnotationAssertion( "galen:Endothelium") +AnnotationAssertion(rdfs:comment "The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980)") AnnotationAssertion(rdfs:label "endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31886,15 +46531,61 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (feces) + +AnnotationAssertion(Annotation( "Wikipedia:Feces") Annotation( "http://www.merriam-webster.com/dictionary/feces") "Portion of semisolid bodily waste discharged through the anus[MW,modified].") +AnnotationAssertion( "BTO:0000440") +AnnotationAssertion( "CALOHA:TS-2345") +AnnotationAssertion( "ENVO:00002003") +AnnotationAssertion( "FMA:64183") +AnnotationAssertion( "GAID:1199") +AnnotationAssertion( "MA:0002509") +AnnotationAssertion( "MAT:0000053") +AnnotationAssertion( "MESH:D005243") +AnnotationAssertion( "MIAA:0000053") +AnnotationAssertion( "NCIT:C13234") +AnnotationAssertion( "Wikipedia:Feces") +AnnotationAssertion( "galen:Feces") +AnnotationAssertion(rdfs:label "feces") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (hyaline cartilage tissue) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000094") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.") +AnnotationAssertion( "EMAPA:35414") +AnnotationAssertion( "FMA:64783") +AnnotationAssertion( "MA:0000109") +AnnotationAssertion( "NCIT:C32746") +AnnotationAssertion( "SCTID:39298000") +AnnotationAssertion( "VSAO:0000094") +AnnotationAssertion( "Wikipedia:Hyaline_cartilage") +AnnotationAssertion( "XAO:0004029") AnnotationAssertion(rdfs:label "hyaline cartilage tissue") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (pulmonary artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Pulmonary_artery") Annotation( "http://orcid.org/0000-0002-6601-2165") "An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood..") +AnnotationAssertion( "AAO:0010221") +AnnotationAssertion( "BTO:0000778") +AnnotationAssertion( "CALOHA:TS-0839") +AnnotationAssertion( "EFO:0001399") +AnnotationAssertion( "EHDAA2:0001575") +AnnotationAssertion( "EHDAA:4351") +AnnotationAssertion( "EMAPA:17008") +AnnotationAssertion( "FMA:66326") +AnnotationAssertion( "GAID:505") +AnnotationAssertion( "MA:0002031") +AnnotationAssertion( "MESH:D011651") +AnnotationAssertion( "NCIT:C12774") +AnnotationAssertion( "SCTID:181380003") +AnnotationAssertion( "VHOG:0000982") +AnnotationAssertion( "Wikipedia:Pulmonary_artery") +AnnotationAssertion( "XAO:0004162") +AnnotationAssertion( "galen:PulmonaryArtery") AnnotationAssertion(rdfs:label "pulmonary artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31909,7 +46600,23 @@ DisjointClasses( (pulmonary vein) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0060577") "Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO].") +AnnotationAssertion( "AAO:0010521") +AnnotationAssertion( "BTO:0001799") +AnnotationAssertion( "CALOHA:TS-0840") +AnnotationAssertion( "EHDAA2:0001579") +AnnotationAssertion( "EHDAA:2629") +AnnotationAssertion( "EMAPA:18645") +AnnotationAssertion( "FMA:66643") +AnnotationAssertion( "GAID:543") +AnnotationAssertion( "MA:0002206") +AnnotationAssertion( "MESH:D011667") +AnnotationAssertion( "NCIT:C12776") +AnnotationAssertion( "SCTID:430160002") +AnnotationAssertion( "VHOG:0001133") +AnnotationAssertion( "Wikipedia:Pulmonary_vein") +AnnotationAssertion( "XAO:0000394") +AnnotationAssertion( "galen:PulmonaryVein") AnnotationAssertion(rdfs:label "pulmonary vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31919,15 +46626,74 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (portal vein) + +AnnotationAssertion(Annotation( "BTO:0001792") "A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO].") +AnnotationAssertion( "BTO:0001792") +AnnotationAssertion( "CALOHA:TS-0814") +AnnotationAssertion( "EHDAA2:0001485") +AnnotationAssertion( "EHDAA:6510") +AnnotationAssertion( "EMAPA:17349") +AnnotationAssertion( "FMA:66645") +AnnotationAssertion( "GAID:540") +AnnotationAssertion( "MA:0002198") +AnnotationAssertion( "MESH:D011169") +AnnotationAssertion( "NCIT:C33343") +AnnotationAssertion( "SCTID:362064007") +AnnotationAssertion( "VHOG:0000656") +AnnotationAssertion( "XAO:0000392") +AnnotationAssertion( "galen:PortalVein") +AnnotationAssertion(rdfs:label "portal vein") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (gray matter) +AnnotationAssertion(Annotation( "Wikipedia:Gray_matter") Annotation( "http://orcid.org/0000-0002-6601-2165") "A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons.") +AnnotationAssertion( "AEO:0001012") +AnnotationAssertion( "EHDAA2:0003136") +AnnotationAssertion( "EHDAA2_RETIRED:0004658") +AnnotationAssertion( "FMA:67242") +AnnotationAssertion( "HBA:4006") +AnnotationAssertion( "MA:0001112") +AnnotationAssertion( "NCIT:C32695") +AnnotationAssertion( "TAO:0002197") +AnnotationAssertion( "VHOG:0001768") +AnnotationAssertion( "Wikipedia:Gray_matter") +AnnotationAssertion( "ZFA:0001681") +AnnotationAssertion( "neuronames:2869") AnnotationAssertion(rdfs:label "gray matter") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (hindbrain) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Rhombencephalon") Annotation( "ZFA:0000029") Annotation( "ZFIN:curator") "The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA].") +AnnotationAssertion( "AAO:0010150") +AnnotationAssertion( "BAMS:HB") +AnnotationAssertion( "BIRNLEX:942") +AnnotationAssertion( "BTO:0000672") +AnnotationAssertion( "CALOHA:TS-0457") +AnnotationAssertion( "DHBA:10653") +AnnotationAssertion( "DMBA:16808") +AnnotationAssertion( "EFO:0000923") +AnnotationAssertion( "EHDAA2:0000746") +AnnotationAssertion( "EHDAA:3514") +AnnotationAssertion( "EHDAA:6487") +AnnotationAssertion( "EMAPA:16916") +AnnotationAssertion( "FMA:67687") +AnnotationAssertion( "MA:0000195") +AnnotationAssertion( "MAT:0000107") +AnnotationAssertion( "MBA:1065") +AnnotationAssertion( "MESH:D012249") +AnnotationAssertion( "MIAA:0000107") +AnnotationAssertion( "NCIT:C40336") +AnnotationAssertion( "SCTID:303456008") +AnnotationAssertion( "TAO:0000029") +AnnotationAssertion( "VHOG:0000070") +AnnotationAssertion( "Wikipedia:Rhombencephalon") +AnnotationAssertion( "XAO:0000015") +AnnotationAssertion( "ZFA:0000029") AnnotationAssertion(rdfs:label "hindbrain") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31935,8 +46701,33 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelium of gall bladder) + +AnnotationAssertion(Annotation( "MP:0009492") "The simple columnar epithelial lining of the gall bladder.") +AnnotationAssertion( "BTO:0001449") +AnnotationAssertion( "CALOHA:TS-1304") +AnnotationAssertion( "EMAPA:35370") +AnnotationAssertion( "FMA:67711") +AnnotationAssertion( "MA:0001632") +AnnotationAssertion( "NCIT:C49227") +AnnotationAssertion(rdfs:label "epithelium of gall bladder") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (epithelium of bronchus) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a bronchus [Automatically generated definition].") +AnnotationAssertion( "BTO:0001845") +AnnotationAssertion( "CALOHA:TS-1240") +AnnotationAssertion( "EFO:0000307") +AnnotationAssertion( "EMAPA:32691") +AnnotationAssertion( "FMA:67782") +AnnotationAssertion( "MA:0001839") +AnnotationAssertion( "NCIT:C32231") AnnotationAssertion(rdfs:label "epithelium of bronchus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31946,6 +46737,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (striated muscle tissue) +AnnotationAssertion(Annotation( "CL:0000737") Annotation( "GOC:dph") Annotation( "GOC:mtg_muscle") "Muscle tissue that contains fibers that are divided by transverse bands into striations.") +AnnotationAssertion( "AAO:0010762") +AnnotationAssertion( "AEO:0000140") +AnnotationAssertion( "CALOHA:TS-2047") +AnnotationAssertion( "EHDAA2:0003140") +AnnotationAssertion( "EMAPA:36390") +AnnotationAssertion( "FMA:67905") +AnnotationAssertion( "MA:0002438") +AnnotationAssertion( "NCIT:C12436") +AnnotationAssertion( "WBbt:0005779") +AnnotationAssertion( "Wikipedia:Striated_muscle") +AnnotationAssertion( "galen:StriatedMuscle") AnnotationAssertion(rdfs:label "striated muscle tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31953,7 +46756,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bronchial artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "UBERON:cjm") Annotation( "Wikipedia:Bronchial_artery") "A systemic artery that supplies the lung with with oxygenated blood.") +AnnotationAssertion( "EMAPA:18608") +AnnotationAssertion( "FMA:68109") +AnnotationAssertion( "GAID:477") +AnnotationAssertion( "MA:0001923") +AnnotationAssertion( "MESH:D001981") +AnnotationAssertion( "NCIT:C32230") +AnnotationAssertion( "SCTID:244247009") +AnnotationAssertion( "Wikipedia:Bronchial_artery") +AnnotationAssertion(rdfs:comment "Although there is much variation, there are usually two bronchial arteries that run to the left lung, and one to the right lung.") AnnotationAssertion(rdfs:label "bronchial artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -31963,6 +46775,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pontine raphe nucleus) +AnnotationAssertion(Annotation( "Wikipedia:Pontine_raphe_nucleus") "The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted].") +AnnotationAssertion( "BAMS:PnR") +AnnotationAssertion( "BAMS:RA-PONS") +AnnotationAssertion( "BAMS:RPn") +AnnotationAssertion( "BIRNLEX:1110") +AnnotationAssertion( "DHBA:12471") +AnnotationAssertion( "DHBA:12475") +AnnotationAssertion( "FMA:68875") +AnnotationAssertion( "HBA:9159") +AnnotationAssertion( "MA:0001022") +AnnotationAssertion( "MBA:238") +AnnotationAssertion( "Wikipedia:Pontine_raphe_nucleus") AnnotationAssertion(rdfs:label "pontine raphe nucleus") SubClassOf( ) SubClassOf( ) @@ -31971,7 +46795,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Respiration organ that develops as an outpocketing of the esophagus.") +AnnotationAssertion( "AAO:0000275") +AnnotationAssertion( "AAO:0010567") +AnnotationAssertion( "BTO:0000763") +AnnotationAssertion( "CALOHA:TS-0568") +AnnotationAssertion( "EFO:0000934") +AnnotationAssertion( "EHDAA2:0001042") +AnnotationAssertion( "EHDAA:1554") +AnnotationAssertion( "EHDAA:2205") +AnnotationAssertion( "EMAPA:16728") +AnnotationAssertion( "EV:0100042") +AnnotationAssertion( "FMA:7195") +AnnotationAssertion( "GAID:345") +AnnotationAssertion( "MA:0000415") +AnnotationAssertion( "MAT:0000135") +AnnotationAssertion( "MESH:D008168") +AnnotationAssertion( "MIAA:0000135") +AnnotationAssertion( "NCIT:C12468") +AnnotationAssertion( "SCTID:181216001") +AnnotationAssertion( "Wikipedia:Lung") +AnnotationAssertion( "XAO:0000119") +AnnotationAssertion( "galen:Lung") +AnnotationAssertion(rdfs:comment "Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP]") AnnotationAssertion(rdfs:label "lung") SubClassOf( ) SubClassOf( ) @@ -31985,7 +46831,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vasculature) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ZFA:0005249") "An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face.") +AnnotationAssertion( "BTO:0003718") +AnnotationAssertion( "FMA:69050") +AnnotationAssertion( "TAO:0005249") +AnnotationAssertion( "ZFA:0005249") AnnotationAssertion(rdfs:label "vasculature") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -31994,6 +46844,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (embryonic structure) +AnnotationAssertion(Annotation( "BTO:0000174") Annotation( "ZFIN:curator") "Anatomical structure that is part of an embryo.") +AnnotationAssertion( "AAO:0000138") +AnnotationAssertion( "BILA:0000034") +AnnotationAssertion( "BTO:0000174") +AnnotationAssertion( "CALOHA:TS-2110") +AnnotationAssertion( "EFO:0000461") +AnnotationAssertion( "FMA:69067") +AnnotationAssertion( "GAID:407") +AnnotationAssertion( "MESH:D004628") +AnnotationAssertion( "NCIT:C13229") +AnnotationAssertion( "RETIRED_EHDAA2:0003169") +AnnotationAssertion( "SCTID:667009") +AnnotationAssertion( "TAO:0001105") +AnnotationAssertion( "VSAO:0000178") +AnnotationAssertion( "XAO:0003042") +AnnotationAssertion( "ZFA:0001105") AnnotationAssertion(rdfs:label "embryonic structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32001,7 +46867,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelium of bronchiole) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a bronchiole [Automatically generated definition].") +AnnotationAssertion( "BTO:0001866") +AnnotationAssertion( "CALOHA:TS-0570") +AnnotationAssertion( "EMAPA:32693") +AnnotationAssertion( "FMA:69077") +AnnotationAssertion( "MA:0001772") +AnnotationAssertion( "NCIT:C48942") AnnotationAssertion(rdfs:label "epithelium of bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32015,6 +46887,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (phrenic artery) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An artery that supplies the diaphragm.") +AnnotationAssertion( "FMA:69330") +AnnotationAssertion( "MA:0002019") +AnnotationAssertion( "NCIT:C33320") AnnotationAssertion(rdfs:label "phrenic artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32022,6 +46898,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (truncus arteriosus) +AnnotationAssertion(Annotation( "Wikipedia:Truncus_arteriosus_(embryology)") "The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles.") +AnnotationAssertion( "EHDAA2:0004143") +AnnotationAssertion( "EMAPA:35887") +AnnotationAssertion( "FMA:70301") +AnnotationAssertion( "GAID:554") +AnnotationAssertion( "MA:0000103") +AnnotationAssertion( "MESH:D014338") +AnnotationAssertion( "NCIT:C34317") +AnnotationAssertion( "SCTID:308828009") +AnnotationAssertion( "Wikipedia:Truncus_arteriosus_(embryology)") AnnotationAssertion(rdfs:label "truncus arteriosus") SubClassOf( ) SubClassOf( ) @@ -32032,6 +46918,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endocardial cushion) +AnnotationAssertion(Annotation( "GO:0003197") Annotation( "Wikipedia:Atrioventricular_cushions") Annotation( "ZFIN:curator") "The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA].") +AnnotationAssertion( "EHDAA2:0000434") +AnnotationAssertion( "EHDAA2:0004028") +AnnotationAssertion( "EHDAA:2586") +AnnotationAssertion( "EMAPA:16696") +AnnotationAssertion( "FMA:70302") +AnnotationAssertion( "MA:0000078") +AnnotationAssertion( "TAO:0001317") +AnnotationAssertion( "VHOG:0000932") +AnnotationAssertion( "Wikipedia:Atrioventricular_cushions") +AnnotationAssertion( "XAO:0004189") +AnnotationAssertion( "ZFA:0001317") +AnnotationAssertion(rdfs:comment "GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form") AnnotationAssertion(rdfs:label "endocardial cushion") SubClassOf( ) SubClassOf( ) @@ -32041,6 +46940,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sinus venosus) +AnnotationAssertion(Annotation( "PMID:20735616") Annotation( "Wikipedia:Sinus_venosus") "The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart.") +AnnotationAssertion( "AAO:0010505") +AnnotationAssertion( "EHDAA2:0001839") +AnnotationAssertion( "EHDAA:480") +AnnotationAssertion( "EMAPA:16237") +AnnotationAssertion( "FMA:70303") +AnnotationAssertion( "NCIT:C34299") +AnnotationAssertion( "NCIT:C34300") +AnnotationAssertion( "TAO:0000154") +AnnotationAssertion( "VHOG:0000177") +AnnotationAssertion( "Wikipedia:Sinus_venosus") +AnnotationAssertion( "ZFA:0000154") AnnotationAssertion(rdfs:label "sinus venosus") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32048,7 +46959,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dermis) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Dermis") Annotation( "ZFIN:curator") "The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP].") +AnnotationAssertion( "AAO:0000128") +AnnotationAssertion( "BTO:0000294") +AnnotationAssertion( "CALOHA:TS-2076") +AnnotationAssertion( "EFO:0000953") +AnnotationAssertion( "EMAPA:17527") +AnnotationAssertion( "EV:0100154") +AnnotationAssertion( "FMA:70323") +AnnotationAssertion( "GAID:1321") +AnnotationAssertion( "MA:0000152") +AnnotationAssertion( "MAT:0000153") +AnnotationAssertion( "MESH:D020405") +AnnotationAssertion( "MIAA:0000153") +AnnotationAssertion( "NCIT:C12701") +AnnotationAssertion( "SCTID:361696001") +AnnotationAssertion( "TAO:0001119") +AnnotationAssertion( "VHOG:0000108") +AnnotationAssertion( "Wikipedia:Dermis") +AnnotationAssertion( "XAO:0000217") +AnnotationAssertion( "ZFA:0001119") AnnotationAssertion(rdfs:label "dermis") SubClassOf( ) SubClassOf( ) @@ -32063,7 +46993,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (hypodermis) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Hypodermis") "Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP].") +AnnotationAssertion( "BTO:0001314") +AnnotationAssertion( "CALOHA:TS-2366") +AnnotationAssertion( "FMA:70544") +AnnotationAssertion( "NCIT:C33645") +AnnotationAssertion( "TAO:0001136") +AnnotationAssertion( "Wikipedia:Hypodermis") +AnnotationAssertion( "ZFA:0001136") AnnotationAssertion(rdfs:label "hypodermis") SubClassOf( ) SubClassOf( ) @@ -32075,6 +47012,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (viscus) +AnnotationAssertion(Annotation( "BTO:0001491") Annotation( "Wikipedia:Viscus") Annotation( "https://github.com/obophenotype/mouse-anatomy-ontology/issues/14") "An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen.") +AnnotationAssertion( "AAO:0010386") +AnnotationAssertion( "BTO:0001491") +AnnotationAssertion( "EHDAA:512") +AnnotationAssertion( "EMAPA:16245") +AnnotationAssertion( "FMA:7085") +AnnotationAssertion( "MA:0000019") +AnnotationAssertion( "MESH:D014781") +AnnotationAssertion( "NCIT:C28287") +AnnotationAssertion( "RETIRED_EHDAA2:0002201") +AnnotationAssertion( "SCTID:118760003") +AnnotationAssertion( "Wikipedia:Viscus") +AnnotationAssertion( "XAO:0003034") AnnotationAssertion(rdfs:label "viscus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32082,7 +47032,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right cardiac atrium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Right_atrium") Annotation( "http://orcid.org/0000-0002-6601-2165") "A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve.") +AnnotationAssertion( "AAO:0010248") +AnnotationAssertion( "BTO:0001703") +AnnotationAssertion( "EHDAA2:0000290") +AnnotationAssertion( "EMAPA:17321") +AnnotationAssertion( "FMA:7096") +AnnotationAssertion( "MA:0000075") +AnnotationAssertion( "NCIT:C12868") +AnnotationAssertion( "SCTID:244383003") +AnnotationAssertion( "VHOG:0000328") +AnnotationAssertion( "Wikipedia:Right_atrium") +AnnotationAssertion( "XAO:0003192") +AnnotationAssertion( "galen:RightAtrium") AnnotationAssertion(rdfs:label "right cardiac atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32091,7 +47053,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left cardiac atrium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Left_atrium") Annotation( "http://orcid.org/0000-0002-6601-2165") "A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve.") +AnnotationAssertion( "AAO:0010247") +AnnotationAssertion( "BTO:0001702") +AnnotationAssertion( "EHDAA2:0000275") +AnnotationAssertion( "EMAPA:17315") +AnnotationAssertion( "FMA:7097") +AnnotationAssertion( "MA:0000074") +AnnotationAssertion( "NCIT:C12869") +AnnotationAssertion( "SCTID:244387002") +AnnotationAssertion( "VHOG:0000369") +AnnotationAssertion( "Wikipedia:Left_atrium") +AnnotationAssertion( "XAO:0003191") +AnnotationAssertion( "galen:LeftAtrium") AnnotationAssertion(rdfs:label "left cardiac atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32100,7 +47074,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart right ventricle) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A cardiac ventricle that is in the right side of the heart.") +AnnotationAssertion( "BTO:0001630") +AnnotationAssertion( "CALOHA:TS-0443") +AnnotationAssertion( "EHDAA2:0000196") +AnnotationAssertion( "EMAPA:17340") +AnnotationAssertion( "FMA:7098") +AnnotationAssertion( "MA:0000093") +AnnotationAssertion( "NCIT:C12870") +AnnotationAssertion( "SCTID:244384009") +AnnotationAssertion( "VHOG:0000717") +AnnotationAssertion( "Wikipedia:Right_ventricle") +AnnotationAssertion( "galen:RightVentricle") AnnotationAssertion(rdfs:label "heart right ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32111,6 +47096,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac atrium) +AnnotationAssertion(Annotation( "Wikipedia:Heart_atrium") Annotation( "http://orcid.org/0000-0002-6601-2165") "Cardiac chamber in which blood enters the heart.") +AnnotationAssertion( "AAO:0010246") +AnnotationAssertion( "BTO:0000903") +AnnotationAssertion( "CALOHA:TS-0437") +AnnotationAssertion( "EFO:0000277") +AnnotationAssertion( "EHDAA2:0000154") +AnnotationAssertion( "EHDAA:1265") +AnnotationAssertion( "EMAPA:16688") +AnnotationAssertion( "EV:0100019") +AnnotationAssertion( "FMA:7099") +AnnotationAssertion( "GAID:555") +AnnotationAssertion( "MA:0000073") +AnnotationAssertion( "MAT:0000496") +AnnotationAssertion( "MESH:D006325") +AnnotationAssertion( "NCIT:C12728") +AnnotationAssertion( "SCTID:261405004") +AnnotationAssertion( "TAO:0000471") +AnnotationAssertion( "VHOG:0000175") +AnnotationAssertion( "Wikipedia:Heart_atrium") +AnnotationAssertion( "ZFA:0000471") +AnnotationAssertion( "galen:Atrium") AnnotationAssertion(rdfs:label "cardiac atrium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32118,6 +47124,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac ventricle) +AnnotationAssertion(Annotation( "Wikipedia:Ventricle_(heart)") Annotation( "http://orcid.org/0000-0002-6601-2165") "Cardiac chamber through which blood leaves the heart.") +AnnotationAssertion( "AAO:0010249") +AnnotationAssertion( "BTO:0000862") +AnnotationAssertion( "CALOHA:TS-0444") +AnnotationAssertion( "EFO:0000317") +AnnotationAssertion( "EHDAA2:0004164") +AnnotationAssertion( "EHDAA:1912") +AnnotationAssertion( "EMAPA:17331") +AnnotationAssertion( "EV:0100020") +AnnotationAssertion( "FMA:7100") +AnnotationAssertion( "GAID:568") +AnnotationAssertion( "MA:0000091") +AnnotationAssertion( "MAT:0000497") +AnnotationAssertion( "MESH:D006352") +AnnotationAssertion( "NCIT:C12730") +AnnotationAssertion( "SCTID:277699000") +AnnotationAssertion( "TAO:0000009") +AnnotationAssertion( "VHOG:0000435") +AnnotationAssertion( "Wikipedia:Ventricle_(heart)") +AnnotationAssertion( "XAO:0003193") +AnnotationAssertion( "ZFA:0000009") +AnnotationAssertion( "galen:Ventricle") AnnotationAssertion(rdfs:label "cardiac ventricle") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32125,7 +47153,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart left ventricle) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A cardiac ventricle that is in the left side of the heart.") +AnnotationAssertion( "BTO:0001629") +AnnotationAssertion( "CALOHA:TS-0439") +AnnotationAssertion( "EHDAA2:0002178") +AnnotationAssertion( "EMAPA:17337") +AnnotationAssertion( "FMA:7101") +AnnotationAssertion( "MA:0000092") +AnnotationAssertion( "NCIT:C12871") +AnnotationAssertion( "SCTID:244385005") +AnnotationAssertion( "VHOG:0000718") +AnnotationAssertion( "Wikipedia:Left_ventricle") +AnnotationAssertion( "galen:LeftVentricle") AnnotationAssertion(rdfs:label "heart left ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32136,6 +47175,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (interatrial septum) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A cardiac septum that divides the left and right atria of the heart.") +AnnotationAssertion( "EHDAA2:0000838") +AnnotationAssertion( "EHDAA:1896") +AnnotationAssertion( "EMAPA:17011") +AnnotationAssertion( "FMA:7108") +AnnotationAssertion( "MA:0000084") +AnnotationAssertion( "NCIT:C32818") +AnnotationAssertion( "SCTID:362016003") +AnnotationAssertion( "VHOG:0000385") +AnnotationAssertion( "Wikipedia:Interatrial_septum") +AnnotationAssertion( "galen:InteratrialSeptum") AnnotationAssertion(rdfs:label "interatrial septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32144,6 +47194,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (postcranial axial skeleton) +AnnotationAssertion(Annotation( "ZFA:0000317") Annotation( "https://sourceforge.net/tracker/?func=detail&aid=2983975&group_id=76834&atid=974957") Annotation( "https://sourceforge.net/tracker/?func=detail&atid=1205376&aid=2983977&group_id=76834") "The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA].") +AnnotationAssertion( "AAO:0000034") +AnnotationAssertion( "EFO:0000942") +AnnotationAssertion( "EHDAA2:0000161") +AnnotationAssertion( "EHDAA:5049") +AnnotationAssertion( "FMA:71221") +AnnotationAssertion( "MA:0002986") +AnnotationAssertion( "MAT:0000148") +AnnotationAssertion( "MIAA:0000148") +AnnotationAssertion( "TAO:0000317") +AnnotationAssertion( "VHOG:0000317") +AnnotationAssertion( "VSAO:0000093") +AnnotationAssertion( "XAO:0003073") +AnnotationAssertion( "ZFA:0000317") +AnnotationAssertion(rdfs:comment "previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed.") AnnotationAssertion(rdfs:label "postcranial axial skeleton") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32152,7 +47217,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (appendicular skeleton) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "UBERONREF:0000003") Annotation( "Wikipedia:Appendicular_skeleton") Annotation( "https://orcid.org/0000-0002-6601-2165") "Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm].") +AnnotationAssertion( "AAO:0000747") +AnnotationAssertion( "EFO:0000951") +AnnotationAssertion( "EMAPA:32729") +AnnotationAssertion( "FMA:71222") +AnnotationAssertion( "MA:0000290") +AnnotationAssertion( "MAT:0000278") +AnnotationAssertion( "MIAA:0000278") +AnnotationAssertion( "NCIT:C49477") +AnnotationAssertion( "SCTID:322050006") +AnnotationAssertion( "VSAO:0000076") +AnnotationAssertion( "Wikipedia:Appendicular_skeleton") +AnnotationAssertion( "XAO:0003166") AnnotationAssertion(rdfs:label "appendicular skeleton") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32162,16 +47239,57 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (interventricular septum) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FMA:7133") "Cardiac septum which separates the right ventricle from the left ventricle.[FMA].") +AnnotationAssertion( "BTO:0002483") +AnnotationAssertion( "EFO:0001956") +AnnotationAssertion( "EHDAA:2603") +AnnotationAssertion( "EMAPA:17333") +AnnotationAssertion( "FMA:7133") +AnnotationAssertion( "MA:0000085") +AnnotationAssertion( "NCIT:C32874") +AnnotationAssertion( "SCTID:362019005") +AnnotationAssertion( "VHOG:0000386") +AnnotationAssertion( "Wikipedia:Interventricular_septum") +AnnotationAssertion( "galen:InterventricularSeptum") AnnotationAssertion(rdfs:label "interventricular septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mesentery) + +AnnotationAssertion(Annotation( "FMA:7144") Annotation( "Wikipedia:Mesentery") Annotation( "Wikipedia:Mesentery#Mesentery_.28general.29") Annotation( "https://github.com/obophenotype/uberon/issues/85") "Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon.") +AnnotationAssertion( "AAO:0011061") +AnnotationAssertion( "BTO:0001380") +AnnotationAssertion( "EV:0100083") +AnnotationAssertion( "FMA:7144") +AnnotationAssertion( "GAID:21") +AnnotationAssertion( "MESH:D008643") +AnnotationAssertion( "NCIT:C33103") +AnnotationAssertion( "SCTID:362707009") +AnnotationAssertion( "Wikipedia:Mesentery#Mesentery_.28general.29") +AnnotationAssertion( "galen:Mesentery") +AnnotationAssertion(rdfs:label "mesentery") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (skin of body) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "UBERON:cjm") "The organ covering the body that consists of the dermis and epidermis.") +AnnotationAssertion( "BTO:0001253") +AnnotationAssertion( "CALOHA:TS-0934") +AnnotationAssertion( "EFO:0000962") +AnnotationAssertion( "EHDAA2:0001844") +AnnotationAssertion( "EMAPA:17525") +AnnotationAssertion( "FMA:7163") +AnnotationAssertion( "MESH:D012867") +AnnotationAssertion( "MFMO:0000099") +AnnotationAssertion( "NCIT:C12470") +AnnotationAssertion( "SCTID:181469002") +AnnotationAssertion( "Wikipedia:Skin") +AnnotationAssertion( "XAO:0000023") +AnnotationAssertion( "galen:Skin") AnnotationAssertion(rdfs:label "skin of body") SubClassOf( ) SubClassOf( ) @@ -32181,6 +47299,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac septum) +AnnotationAssertion(Annotation( "MESH:A07.541.459") "The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles.") +AnnotationAssertion( "EMAPA:35400") +AnnotationAssertion( "FMA:7180") +AnnotationAssertion( "GAID:562") +AnnotationAssertion( "MA:0000083") +AnnotationAssertion( "MESH:D006346") +AnnotationAssertion( "NCIT:C49485") +AnnotationAssertion( "SCTID:362014000") AnnotationAssertion(rdfs:label "cardiac septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32191,24 +47317,206 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trunk) +AnnotationAssertion(Annotation( "TAO:0001115") Annotation( "UBERONREF:0000006") Annotation( "Wikipedia:Torso") "Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.") +AnnotationAssertion( "AAO:0010339") +AnnotationAssertion( "BILA:0000116") +AnnotationAssertion( "BTO:0001493") +AnnotationAssertion( "CALOHA:TS-1071") +AnnotationAssertion( "EFO:0000966") +AnnotationAssertion( "EMAPA:31857") +AnnotationAssertion( "FMA:7181") +AnnotationAssertion( "MA:0000004") +AnnotationAssertion( "MAT:0000296") +AnnotationAssertion( "MIAA:0000296") +AnnotationAssertion( "NCIT:C33816") +AnnotationAssertion( "SCTID:262225004") +AnnotationAssertion( "TAO:0001115") +AnnotationAssertion( "Wikipedia:Torso") +AnnotationAssertion( "XAO:0000054") +AnnotationAssertion( "XAO:0003025") +AnnotationAssertion( "ZFA:0001115") +AnnotationAssertion( "galen:Trunk") AnnotationAssertion(rdfs:label "trunk") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (visual system) +AnnotationAssertion(Annotation( "NIFSTD:FMAID_7191") "The sensory system subserving the sense of vision.") +AnnotationAssertion( "AAO:0000632") +AnnotationAssertion( "BILA:0000140") +AnnotationAssertion( "EMAPA:36003") +AnnotationAssertion( "FMA:7191") +AnnotationAssertion( "MA:0002444") +AnnotationAssertion( "NCIT:C12888") +AnnotationAssertion( "SCTID:281831001") +AnnotationAssertion( "TAO:0001127") +AnnotationAssertion( "Wikipedia:Visual_system") +AnnotationAssertion( "XAO:0003198") +AnnotationAssertion( "ZFA:0001127") +AnnotationAssertion( "http://uri.neuinfo.org/nif/nifstd/FMAID_7191") AnnotationAssertion(rdfs:label "visual system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vestibulo-auditory system) +AnnotationAssertion(Annotation( "ZFA:0001138") "Sensory system responsible for the perception of spatial orientation and auditory stimuli.") +AnnotationAssertion( "AAO:0000631") +AnnotationAssertion( "FMA:78500") +AnnotationAssertion( "TAO:0001138") +AnnotationAssertion( "XAO:0003195") +AnnotationAssertion( "ZFA:0001138") AnnotationAssertion(rdfs:label "vestibulo-auditory system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (spleen) + +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0000689") "The organ that functions to filter blood and to store red corpuscles and platelets.") +AnnotationAssertion( "AAO:0010395") +AnnotationAssertion( "BTO:0001281") +AnnotationAssertion( "CALOHA:TS-0956") +AnnotationAssertion( "EFO:0000869") +AnnotationAssertion( "EMAPA:18767") +AnnotationAssertion( "EV:0100055") +AnnotationAssertion( "FMA:7196") +AnnotationAssertion( "GAID:1289") +AnnotationAssertion( "MA:0000141") +AnnotationAssertion( "MAT:0000085") +AnnotationAssertion( "MESH:D013154") +AnnotationAssertion( "MIAA:0000085") +AnnotationAssertion( "NCIT:C12432") +AnnotationAssertion( "SCTID:181279003") +AnnotationAssertion( "TAO:0000436") +AnnotationAssertion( "VHOG:0000120") +AnnotationAssertion( "Wikipedia:Spleen") +AnnotationAssertion( "XAO:0000328") +AnnotationAssertion( "ZFA:0000436") +AnnotationAssertion( "galen:Spleen") +AnnotationAssertion(rdfs:label "spleen") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (liver) + +AnnotationAssertion(Annotation( "BTO:0000759") Annotation( "Wikipedia:Liver") "An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].") +AnnotationAssertion( "AAO:0010111") +AnnotationAssertion( "BTO:0000759") +AnnotationAssertion( "CALOHA:TS-0564") +AnnotationAssertion( "EFO:0000887") +AnnotationAssertion( "EHDAA2:0000997") +AnnotationAssertion( "EHDAA:2197") +AnnotationAssertion( "EMAPA:16846") +AnnotationAssertion( "EV:0100089") +AnnotationAssertion( "FMA:7197") +AnnotationAssertion( "GAID:288") +AnnotationAssertion( "MA:0000358") +AnnotationAssertion( "MAT:0000097") +AnnotationAssertion( "MESH:D008099") +AnnotationAssertion( "MIAA:0000097") +AnnotationAssertion( "NCIT:C12392") +AnnotationAssertion( "SCTID:181268008") +AnnotationAssertion( "TAO:0000123") +AnnotationAssertion( "VHOG:0000257") +AnnotationAssertion( "Wikipedia:Liver") +AnnotationAssertion( "XAO:0000133") +AnnotationAssertion( "ZFA:0000123") +AnnotationAssertion( "galen:Liver") +AnnotationAssertion(rdfs:label "liver") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (small intestine) + +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Small_intestine") "Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong].") +AnnotationAssertion( "AAO:0010397") +AnnotationAssertion( "BTO:0000651") +AnnotationAssertion( "CALOHA:TS-0942") +AnnotationAssertion( "EFO:0000841") +AnnotationAssertion( "EMAPA:32834") +AnnotationAssertion( "EV:0100072") +AnnotationAssertion( "FMA:7200") +AnnotationAssertion( "GAID:313") +AnnotationAssertion( "MA:0000337") +AnnotationAssertion( "MAT:0000047") +AnnotationAssertion( "MESH:D007421") +AnnotationAssertion( "MIAA:0000047") +AnnotationAssertion( "NCIT:C12386") +AnnotationAssertion( "SCTID:181250005") +AnnotationAssertion( "TAO:0001323") +AnnotationAssertion( "VHOG:0000055") +AnnotationAssertion( "Wikipedia:Small_intestine") +AnnotationAssertion( "XAO:0000130") +AnnotationAssertion( "ZFA:0001323") +AnnotationAssertion( "galen:SmallIntestine") +AnnotationAssertion(rdfs:label "small intestine") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (gallbladder) + +AnnotationAssertion(Annotation( "Wikipedia:Gallbladder") "An organ that aids digestion and stores bile produced by the liver[WP].") +AnnotationAssertion( "AAO:0010114") +AnnotationAssertion( "BTO:0000493") +AnnotationAssertion( "CALOHA:TS-0394") +AnnotationAssertion( "EFO:0000853") +AnnotationAssertion( "EHDAA2:0000699") +AnnotationAssertion( "EHDAA:8062") +AnnotationAssertion( "EMAPA:17202") +AnnotationAssertion( "EV:0100090") +AnnotationAssertion( "FMA:7202") +AnnotationAssertion( "MA:0000356") +AnnotationAssertion( "MAT:0000072") +AnnotationAssertion( "MESH:D005704") +AnnotationAssertion( "MIAA:0000072") +AnnotationAssertion( "NCIT:C12377") +AnnotationAssertion( "SCTID:181269000") +AnnotationAssertion( "TAO:0000208") +AnnotationAssertion( "VHOG:0000221") +AnnotationAssertion( "Wikipedia:Gallbladder") +AnnotationAssertion( "XAO:0000135") +AnnotationAssertion( "ZFA:0000208") +AnnotationAssertion( "galen:Gallbladder") +AnnotationAssertion(rdfs:comment "Rats do not have a gallbladder, but produce bile. The bile flows directly from the liver through the (hepatic) bile duct into the small intestine (Hebel and Stromberg, 1988)") +AnnotationAssertion(rdfs:label "gallbladder") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (artery smooth muscle tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of an artery [Automatically generated definition].") +AnnotationAssertion( "BTO:0000087") +AnnotationAssertion( "CALOHA:TS-1198") +AnnotationAssertion( "EMAPA:36285") +AnnotationAssertion( "FMA:72024") +AnnotationAssertion( "MA:0000708") +AnnotationAssertion( "NCIT:C49195") AnnotationAssertion(rdfs:label "artery smooth muscle tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32217,14 +47525,51 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (smooth muscle of esophagus) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35323") +AnnotationAssertion( "FMA:72025") +AnnotationAssertion( "MA:0001573") AnnotationAssertion(rdfs:label "smooth muscle of esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (duodenum) + +AnnotationAssertion(Annotation( "ISBN:0815318960") Annotation( "Wikipedia:Duodenum") "The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one).") +AnnotationAssertion( "AAO:0010402") +AnnotationAssertion( "BTO:0000365") +AnnotationAssertion( "CALOHA:TS-0214") +AnnotationAssertion( "EFO:0000851") +AnnotationAssertion( "EMAPA:18852") +AnnotationAssertion( "EV:0100073") +AnnotationAssertion( "FMA:7206") +AnnotationAssertion( "GAID:284") +AnnotationAssertion( "MA:0000338") +AnnotationAssertion( "MAT:0000044") +AnnotationAssertion( "MESH:D004386") +AnnotationAssertion( "MIAA:0000044") +AnnotationAssertion( "NCIT:C12263") +AnnotationAssertion( "SCTID:181247007") +AnnotationAssertion( "VHOG:0000052") +AnnotationAssertion( "Wikipedia:Duodenum") +AnnotationAssertion( "XAO:0000236") +AnnotationAssertion( "galen:Duodenum") +AnnotationAssertion(rdfs:label "duodenum") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (right ovary) +AnnotationAssertion(Annotation( "OBOL:automatic") "An ovary that is part of a right side of organism [Automatically generated definition].") +AnnotationAssertion( "FMA:7213") +AnnotationAssertion( "MA:0001705") +AnnotationAssertion( "NCIT:C33487") +AnnotationAssertion( "SCTID:280123002") AnnotationAssertion(rdfs:label "right ovary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32233,6 +47578,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left ovary) +AnnotationAssertion(Annotation( "OBOL:automatic") "An ovary that is part of a left side of organism [Automatically generated definition].") +AnnotationAssertion( "FMA:7214") +AnnotationAssertion( "MA:0001704") +AnnotationAssertion( "NCIT:C32969") +AnnotationAssertion( "SCTID:280124008") AnnotationAssertion(rdfs:label "left ovary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32241,6 +47591,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (superior olivary complex) +AnnotationAssertion(Annotation( "ISBN:0-19-502694-2") Annotation( "Wikipedia:Superior_olivary_complex") "A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system.") +AnnotationAssertion( "BAMS:SOC") +AnnotationAssertion( "BIRNLEX:1307") +AnnotationAssertion( "DHBA:12462") +AnnotationAssertion( "EMAPA:35840") +AnnotationAssertion( "EV:0100263") +AnnotationAssertion( "FMA:72247") +AnnotationAssertion( "HBA:9177") +AnnotationAssertion( "MA:0001026") +AnnotationAssertion( "MBA:398") +AnnotationAssertion( "VHOG:0001381") +AnnotationAssertion( "Wikipedia:Superior_olivary_complex") AnnotationAssertion(rdfs:label "superior olivary complex") SubClassOf( ) SubClassOf( ) @@ -32249,6 +47611,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (locus ceruleus) +AnnotationAssertion(Annotation( "GAID:577") Annotation( "GO:0021703") Annotation( "Wikipedia:Locus_ceruleus") "The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID].") +AnnotationAssertion( "BAMS:CAE") +AnnotationAssertion( "BAMS:LC") +AnnotationAssertion( "BIRNLEX:905") +AnnotationAssertion( "BM:Pons-LC") +AnnotationAssertion( "BTO:0001408") +AnnotationAssertion( "DHBA:12819") +AnnotationAssertion( "DMBA:16972") +AnnotationAssertion( "EFO:0001963") +AnnotationAssertion( "EMAPA:35502") +AnnotationAssertion( "FMA:72478") +AnnotationAssertion( "GAID:577") +AnnotationAssertion( "HBA:9148") +AnnotationAssertion( "MA:0001017") +AnnotationAssertion( "MBA:147") +AnnotationAssertion( "MESH:D008125") +AnnotationAssertion( "NCIT:C97333") +AnnotationAssertion( "SCTID:369016004") +AnnotationAssertion( "TAO:0000539") +AnnotationAssertion( "Wikipedia:Locus_ceruleus") +AnnotationAssertion( "ZFA:0000539") AnnotationAssertion(rdfs:label "locus ceruleus") SubClassOf( ) SubClassOf( ) @@ -32258,6 +47641,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (superior salivatory nucleus) +AnnotationAssertion(Annotation( "BIRNLEX:1131") "Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703).") +AnnotationAssertion( "BAMS:SSN") +AnnotationAssertion( "BAMS:SuS") +AnnotationAssertion( "BIRNLEX:1131") +AnnotationAssertion( "DHBA:12435") +AnnotationAssertion( "EHDAA2:0004646") +AnnotationAssertion( "FMA:72482") +AnnotationAssertion( "HBA:9194") +AnnotationAssertion( "MA:0001027") +AnnotationAssertion( "MBA:462") +AnnotationAssertion( "SCTID:369028007") +AnnotationAssertion( "Wikipedia:Superior_salivatory_nucleus") AnnotationAssertion(rdfs:label "superior salivatory nucleus") SubClassOf( ) SubClassOf( ) @@ -32267,6 +47662,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endocardium) +AnnotationAssertion(Annotation( "GO:0003157") "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO].") +AnnotationAssertion( "AAO:0010408") +AnnotationAssertion( "BTO:0000387") +AnnotationAssertion( "CALOHA:TS-2075") +AnnotationAssertion( "EFO:0000821") +AnnotationAssertion( "EHDAA2:0004153") +AnnotationAssertion( "EMAPA:17868") +AnnotationAssertion( "EMAPA:32686") +AnnotationAssertion( "EV:0100021") +AnnotationAssertion( "FMA:7280") +AnnotationAssertion( "GAID:550") +AnnotationAssertion( "MA:0000076") +AnnotationAssertion( "MAT:0000455") +AnnotationAssertion( "MESH:D004699") +AnnotationAssertion( "NCIT:C13004") +AnnotationAssertion( "SCTID:362013006") +AnnotationAssertion( "TAO:0001320") +AnnotationAssertion( "VHOG:0000084") +AnnotationAssertion( "Wikipedia:Endocardium") +AnnotationAssertion( "XAO:0000066") +AnnotationAssertion( "ZFA:0001320") +AnnotationAssertion( "galen:Endocardium") +AnnotationAssertion(rdfs:comment "fixed in GO to reflect FMA. See email to David/Varsha June 18 2010") AnnotationAssertion(rdfs:label "endocardium") SubClassOf( ) SubClassOf( ) @@ -32275,6 +47693,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endocardium of atrium) +AnnotationAssertion(Annotation( "ZFIN:curator") "Endocardium that is part of the atrium.") +AnnotationAssertion( "EMAPA:32745") +AnnotationAssertion( "FMA:7284") +AnnotationAssertion( "MA:0000077") +AnnotationAssertion( "SCTID:192001005") +AnnotationAssertion( "TAO:0002169") +AnnotationAssertion( "VHOG:0000606") +AnnotationAssertion( "ZFA:0001614") AnnotationAssertion(rdfs:label "endocardium of atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32283,6 +47709,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right lung) +AnnotationAssertion(Annotation( "FMA:FMA") Annotation( "Wikipedia:Right_lung") "Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA].") +AnnotationAssertion( "EHDAA2:0001730") +AnnotationAssertion( "EHDAA:4969") +AnnotationAssertion( "EMAPA:17661") +AnnotationAssertion( "FMA:7309") +AnnotationAssertion( "MA:0000426") +AnnotationAssertion( "NCIT:C33483") +AnnotationAssertion( "SCTID:361967000") +AnnotationAssertion( "VHOG:0000301") +AnnotationAssertion( "Wikipedia:Right_lung") AnnotationAssertion(rdfs:label "right lung") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32290,6 +47726,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left lung) +AnnotationAssertion(Annotation( "FMA:FMA") Annotation( "Wikipedia:Left_lung") "Lung which consists of the left upper lobe and left lower lobe.[FMA].") +AnnotationAssertion( "EHDAA2:0000943") +AnnotationAssertion( "EHDAA:4947") +AnnotationAssertion( "EMAPA:17653") +AnnotationAssertion( "FMA:7310") +AnnotationAssertion( "MA:0000425") +AnnotationAssertion( "NCIT:C32967") +AnnotationAssertion( "SCTID:361982005") +AnnotationAssertion( "VHOG:0000618") +AnnotationAssertion( "Wikipedia:Left_lung") AnnotationAssertion(rdfs:label "left lung") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32297,6 +47743,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (alveolar sac) +AnnotationAssertion(Annotation( "MP:0010902") Annotation( "Wikipedia:Alveolar_sac") "The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters.") +AnnotationAssertion( "BTO:0000061") +AnnotationAssertion( "EMAPA:35119") +AnnotationAssertion( "FMA:7317") +AnnotationAssertion( "MA:0000418") +AnnotationAssertion( "NCIT:C32057") +AnnotationAssertion( "SCTID:361964007") +AnnotationAssertion( "Wikipedia:Alveolar_sac") AnnotationAssertion(rdfs:label "alveolar sac") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32309,14 +47763,35 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pulmonary alveolar duct) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MGI:cwg") Annotation( "MP:0002271") "The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli.") +AnnotationAssertion( "EMAPA:32694") +AnnotationAssertion( "FMA:7341") +AnnotationAssertion( "MA:0000417") +AnnotationAssertion( "NCIT:C32056") +AnnotationAssertion( "Wikipedia:Alveolar_duct") AnnotationAssertion(rdfs:label "pulmonary alveolar duct") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (bronchus) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-397-51047-0") Annotation( "MESH:A04.411.125") Annotation( "MGI:cwg") Annotation( "MP:0002264") "The upper conducting airways of the lung; these airways arise from the terminus of the trachea.") +AnnotationAssertion( "BTO:0001340") +AnnotationAssertion( "CALOHA:TS-1229") +AnnotationAssertion( "EFO:0000932") +AnnotationAssertion( "EMAPA:32689") +AnnotationAssertion( "EV:0100041") +AnnotationAssertion( "FMA:7409") +AnnotationAssertion( "GAID:346") +AnnotationAssertion( "MA:0000436") +AnnotationAssertion( "MAT:0000133") +AnnotationAssertion( "MESH:D001980") +AnnotationAssertion( "MIAA:0000133") +AnnotationAssertion( "NCIT:C12683") +AnnotationAssertion( "SCTID:181215002") +AnnotationAssertion( "VHOG:0000262") +AnnotationAssertion( "Wikipedia:Bronchus") +AnnotationAssertion( "XAO:0000121") AnnotationAssertion(rdfs:label "bronchus") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32324,6 +47799,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bronchiole) +AnnotationAssertion(Annotation( "ISBN:0-397-51047-0") Annotation( "MGI:cwg") Annotation( "MP:0002267") "The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching.") +AnnotationAssertion( "BTO:0002375") +AnnotationAssertion( "CALOHA:TS-2003") +AnnotationAssertion( "EHDAA:8171") +AnnotationAssertion( "EHDAA:8183") +AnnotationAssertion( "EHDAA:8199") +AnnotationAssertion( "EHDAA:8221") +AnnotationAssertion( "EMAPA:32697") +AnnotationAssertion( "FMA:7410") +AnnotationAssertion( "MA:0000422") +AnnotationAssertion( "NCIT:C12684") +AnnotationAssertion( "SCTID:278982001") +AnnotationAssertion( "VHOG:0000675") +AnnotationAssertion( "Wikipedia:Bronchiole") +AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/issues/2795") rdfs:comment "In some texts/references/ontologies, bronchiole has been used as an exact synonym of 'lobular bronchiole'. However, a 'lobular bronchiole' is a segment of a bronchiole.") AnnotationAssertion(rdfs:label "bronchiole") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32331,7 +47821,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (terminal bronchiole) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0-397-51047-0") Annotation( "MGI:cwg") Annotation( "MP:0002268") Annotation( "PMID:16543587") "A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls.") +AnnotationAssertion( "BTO:0003223") +AnnotationAssertion( "EMAPA:36282") +AnnotationAssertion( "FMA:7411") +AnnotationAssertion( "MA:0000424") +AnnotationAssertion( "NCIT:C33754") +AnnotationAssertion( "SCTID:278981008") +AnnotationAssertion( "Wikipedia:Terminal_bronchiole") AnnotationAssertion(rdfs:label "terminal bronchiole") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32340,7 +47837,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory bronchiole) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0123813611") Annotation( "Wikipedia:Respiratory_bronchiole") "A bronchiole that is the first segment of the respiratory zone.") +AnnotationAssertion( "BTO:0003222") +AnnotationAssertion( "EMAPA:35729") +AnnotationAssertion( "FMA:7412") +AnnotationAssertion( "MA:0000423") +AnnotationAssertion( "NCIT:C33465") +AnnotationAssertion( "SCTID:128517006") +AnnotationAssertion( "Wikipedia:Respiratory_bronchiole") AnnotationAssertion(rdfs:label "respiratory bronchiole") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32350,7 +47854,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (subcutaneous adipose tissue) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A portion of adipose tissue that is part of the hypodermis, beneath the dermis.") +AnnotationAssertion( "BTO:0004042") +AnnotationAssertion( "EMAPA:35829") +AnnotationAssertion( "FMA:74315") +AnnotationAssertion( "MA:0000473") AnnotationAssertion(rdfs:label "subcutaneous adipose tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32360,13 +47868,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (hemolymphoid system) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs.") +AnnotationAssertion( "CALOHA:TS-2018") +AnnotationAssertion( "EHDAA2:0004615") +AnnotationAssertion( "EMAPA:18765") +AnnotationAssertion( "FMA:74562") +AnnotationAssertion( "MA:0000013") AnnotationAssertion(rdfs:label "hemolymphoid system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (integument) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Integument") "The dermis, epidermis and hypodermis.") +AnnotationAssertion( "AAO:0000239") +AnnotationAssertion( "BTO:0000634") +AnnotationAssertion( "FMA:74657") +AnnotationAssertion( "TAO:0000368") +AnnotationAssertion( "VSAO:0000029") +AnnotationAssertion( "Wikipedia:Integument") +AnnotationAssertion( "ZFA:0000368") +AnnotationAssertion( "galen:Integument") AnnotationAssertion(rdfs:label "integument") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32377,6 +47899,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vasculature of head) +AnnotationAssertion(Annotation( "OBOL:automatic") "Vasculature that is part of a head [Automatically generated definition].") +AnnotationAssertion( "EFO:0003656") +AnnotationAssertion( "FMA:74710") +AnnotationAssertion( "TAO:0001267") +AnnotationAssertion( "XAO:0004152") +AnnotationAssertion( "ZFA:0001267") AnnotationAssertion(rdfs:label "vasculature of head") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32384,6 +47912,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vasculature of trunk) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vasculature that is part of a trunk [Automatically generated definition].") +AnnotationAssertion( "FMA:74712") +AnnotationAssertion( "TAO:0005024") +AnnotationAssertion( "ZFA:0005024") AnnotationAssertion(rdfs:label "vasculature of trunk") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32391,7 +47923,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (submucosa of trachea) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a trachea.") +AnnotationAssertion( "BTO:0002115") +AnnotationAssertion( "EMAPA:35879") +AnnotationAssertion( "FMA:7472") +AnnotationAssertion( "MA:0001860") +AnnotationAssertion( "NCIT:C49307") +AnnotationAssertion( "SCTID:4419000") AnnotationAssertion(rdfs:label "submucosa of trachea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32400,7 +47938,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vasculature of eye) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") Annotation( "https://sourceforge.net/tracker/?func=detail&aid=3489658&group_id=76834&atid=994726") "Vasculature that is part of the eye region.") +AnnotationAssertion( "FMA:74743") +AnnotationAssertion( "SCTID:123846009") +AnnotationAssertion( "TAO:0007057") +AnnotationAssertion( "ZFA:0007057") AnnotationAssertion(rdfs:label "vasculature of eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32410,6 +47952,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (musculoskeletal system) +AnnotationAssertion(Annotation( "VSAO:0000031") Annotation( "VSAO:curator") Annotation( "https://github.com/obophenotype/uberon/issues/77") "Anatomical system that consists of the muscular and skeletal systems.") +AnnotationAssertion( "AAO:0010546") +AnnotationAssertion( "CALOHA:TS-1311") +AnnotationAssertion( "EMAPA:32714") +AnnotationAssertion( "EV:0100139") +AnnotationAssertion( "FMA:7482") +AnnotationAssertion( "GAID:98") +AnnotationAssertion( "MA:0002418") +AnnotationAssertion( "MESH:D009141") +AnnotationAssertion( "NCIT:C12754") +AnnotationAssertion( "SCTID:278858007") +AnnotationAssertion( "VHOG:0001275") +AnnotationAssertion( "VSAO:0000031") +AnnotationAssertion( "Wikipedia:Musculoskeletal_system") +AnnotationAssertion( "XAO:0000168") AnnotationAssertion(rdfs:label "musculoskeletal system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32417,15 +47974,25 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) # Class: (cartilaginous joint) +AnnotationAssertion(Annotation( "FMA:FMA") Annotation( "Wikipedia:Cartilaginous_joint") "Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA].") +AnnotationAssertion( "EMAPA:36581") +AnnotationAssertion( "FMA:7496") +AnnotationAssertion( "MA:0000320") +AnnotationAssertion( "SCTID:58442004") +AnnotationAssertion( "TAO:0005155") +AnnotationAssertion( "Wikipedia:Cartilaginous_joint") +AnnotationAssertion( "ZFA:0005155") AnnotationAssertion(rdfs:label "cartilaginous joint") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32433,6 +48000,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (synovial joint) +AnnotationAssertion(Annotation( "FMA:7501") Annotation( "Wikipedia:Synovial_joint") "Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA].") +AnnotationAssertion( "AEO:0000183") +AnnotationAssertion( "CALOHA:TS-2138") +AnnotationAssertion( "EHDAA2:0003183") +AnnotationAssertion( "FMA:7501") +AnnotationAssertion( "MA:0000322") +AnnotationAssertion( "NCIT:C32461") +AnnotationAssertion( "SCTID:113234001") +AnnotationAssertion( "TAO:0005153") +AnnotationAssertion( "Wikipedia:Synovial_joint") +AnnotationAssertion( "ZFA:0005153") +AnnotationAssertion( "galen:SynovialJoint") AnnotationAssertion(rdfs:label "synovial joint") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32442,6 +48021,15 @@ DisjointClasses( (thoracic cavity) +AnnotationAssertion(Annotation( "UBERON:cjm") Annotation( "Wikipedia:Thoracic_cavity") "The part of the coelemic cavity lumen that is enclosed by the walls of the thorax.") +AnnotationAssertion( "EMAPA:36497") +AnnotationAssertion( "FMA:7565") +AnnotationAssertion( "GAID:93") +AnnotationAssertion( "MA:0000032") +AnnotationAssertion( "MESH:D035423") +AnnotationAssertion( "NCIT:C12905") +AnnotationAssertion( "SCTID:243949006") +AnnotationAssertion( "Wikipedia:Thoracic_cavity") AnnotationAssertion(rdfs:label "thoracic cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32450,7 +48038,34 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (spinal cord) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "BIRNLEX:1709") "Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).") +AnnotationAssertion( "AAO:0010151") +AnnotationAssertion( "BAMS:SP") +AnnotationAssertion( "BAMS:Spinal") +AnnotationAssertion( "BIRNLEX:1709") +AnnotationAssertion( "BM:SpC") +AnnotationAssertion( "BTO:0001279") +AnnotationAssertion( "CALOHA:TS-0953") +AnnotationAssertion( "DHBA:12890") +AnnotationAssertion( "DMBA:17651") +AnnotationAssertion( "EFO:0000110") +AnnotationAssertion( "EHDAA2:0001255") +AnnotationAssertion( "EHDAA:2863") +AnnotationAssertion( "EMAPA:17577") +AnnotationAssertion( "EV:0100316") +AnnotationAssertion( "FMA:7647") +AnnotationAssertion( "GAID:695") +AnnotationAssertion( "MA:0000216") +AnnotationAssertion( "MAT:0000183") +AnnotationAssertion( "MESH:D013116") +AnnotationAssertion( "MIAA:0000183") +AnnotationAssertion( "NCIT:C12464") +AnnotationAssertion( "SCTID:180959008") +AnnotationAssertion( "TAO:0000075") +AnnotationAssertion( "VHOG:0000601") +AnnotationAssertion( "Wikipedia:Spinal_cord") +AnnotationAssertion( "XAO:0000020") +AnnotationAssertion( "ZFA:0000075") AnnotationAssertion(rdfs:label "spinal cord") SubClassOf( ) SubClassOf( ) @@ -32464,12 +48079,35 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (chondrocranium) +AnnotationAssertion(Annotation( "Wikipedia:Chondrocranium") Annotation( "http://medical-dictionary.thefreedictionary.com/chondrocranium") "Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD].") +AnnotationAssertion( "AAO:0010169") +AnnotationAssertion( "EHDAA2:0000243") +AnnotationAssertion( "EMAPA:17681") +AnnotationAssertion( "TAO:0001424") +AnnotationAssertion( "VHOG:0000288") +AnnotationAssertion( "Wikipedia:Chondrocranium") +AnnotationAssertion( "ZFA:0001424") AnnotationAssertion(rdfs:label "chondrocranium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (ventral horn of spinal cord) +AnnotationAssertion(Annotation( "GO:0021517") Annotation( "MP:0005112") Annotation( "Wikipedia:Anterior_horn_of_spinal_cord") Annotation( "https://sourceforge.net/tracker/?group_id=36855&atid=440764") "The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO].") +AnnotationAssertion( "BAMS:VH") +AnnotationAssertion( "BIRNLEX:2668") +AnnotationAssertion( "BTO:0005151") +AnnotationAssertion( "EMAPA:18575") +AnnotationAssertion( "EMAPA:35794") +AnnotationAssertion( "FMA:256541") +AnnotationAssertion( "MA:0001134") +AnnotationAssertion( "NCIT:C33859") +AnnotationAssertion( "SCTID:279443000") +AnnotationAssertion( "TAO:0000702") +AnnotationAssertion( "VHOG:0001288") +AnnotationAssertion( "Wikipedia:Anterior_horn_of_spinal_cord") +AnnotationAssertion( "ZFA:0000702") +AnnotationAssertion( "neuronames:1751") AnnotationAssertion(rdfs:label "ventral horn of spinal cord") SubClassOf( ) SubClassOf( ) @@ -32480,12 +48118,86 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (reticular formation) +AnnotationAssertion(Annotation( "NeuroNames:1223") "A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ).") +AnnotationAssertion( "BAMS:RET") +AnnotationAssertion( "EMAPA:35188") +AnnotationAssertion( "FMA:77719") +AnnotationAssertion( "MA:0003185") +AnnotationAssertion( "MESH:D012154") +AnnotationAssertion( "NLX:143558") +AnnotationAssertion( "SCTID:361552007") +AnnotationAssertion( "Wikipedia:Reticular_formation") +AnnotationAssertion( "neuronames:1223") AnnotationAssertion(rdfs:label "reticular formation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (biliary system) + +AnnotationAssertion(Annotation( "Wikipedia:Biliary_system") "Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree).") +AnnotationAssertion( "FMA:79646") +AnnotationAssertion( "GAID:279") +AnnotationAssertion( "MA:0001273") +AnnotationAssertion( "MESH:D001659") +AnnotationAssertion( "NCIT:C12678") +AnnotationAssertion( "SCTID:361354009") +AnnotationAssertion( "Wikipedia:Biliary_system") +AnnotationAssertion(rdfs:label "biliary system") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +DisjointClasses( ) +DisjointClasses( ) +DisjointClasses( ) +DisjointClasses( ) +DisjointClasses( ) +DisjointClasses( ) +DisjointClasses( ) + +# Class: (dorsal mesentery) + +AnnotationAssertion(Annotation( "Wikipedia:Dorsal_mesentery") Annotation( "Wikipedia:Mesentery#Development") Annotation( "ZFIN:curator") "The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA].") +AnnotationAssertion( "EHDAA2:0004560") +AnnotationAssertion( "EHDAA:3019") +AnnotationAssertion( "EHDAA:3033") +AnnotationAssertion( "EHDAA:3921") +AnnotationAssertion( "EHDAA:3934") +AnnotationAssertion( "EHDAA:3957") +AnnotationAssertion( "EHDAA:3971") +AnnotationAssertion( "FMA:79795") +AnnotationAssertion( "SCTID:308823000") +AnnotationAssertion( "TAO:0005130") +AnnotationAssertion( "Wikipedia:Mesentery#Development") +AnnotationAssertion( "ZFA:0005130") +AnnotationAssertion(rdfs:label "dorsal mesentery") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (brainstem) +AnnotationAssertion(Annotation( "ISBN:0471888893") Annotation( "MP:0005277") Annotation( "Wikipedia:Brainstem") Annotation( "ZFA:0001707") "Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized].") +AnnotationAssertion( "BAMS:BS") +AnnotationAssertion( "BIRNLEX:1565") +AnnotationAssertion( "BTO:0000146") +AnnotationAssertion( "CALOHA:TS-0093") +AnnotationAssertion( "EFO:0001962") +AnnotationAssertion( "EMAPA:32678") +AnnotationAssertion( "EV:0100241") +AnnotationAssertion( "FMA:79876") +AnnotationAssertion( "MA:0000169") +AnnotationAssertion( "MBA:343") +AnnotationAssertion( "MESH:D001933") +AnnotationAssertion( "NCIT:C12441") +AnnotationAssertion( "SCTID:180925009") +AnnotationAssertion( "TAO:0002156") +AnnotationAssertion( "VHOG:0001457") +AnnotationAssertion( "Wikipedia:Brainstem") +AnnotationAssertion( "ZFA:0001707") +AnnotationAssertion(rdfs:comment "'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions).") AnnotationAssertion(rdfs:label "brainstem") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32495,7 +48207,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (alveolus of lung) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Pulmonary_alveolus") "Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP].") +AnnotationAssertion( "BTO:0000060") +AnnotationAssertion( "CALOHA:TS-0031") +AnnotationAssertion( "EFO:0001985") +AnnotationAssertion( "EMAPA:32682") +AnnotationAssertion( "FMA:7318") +AnnotationAssertion( "GAID:349") +AnnotationAssertion( "MA:0000420") +AnnotationAssertion( "MESH:D011650") +AnnotationAssertion( "SCTID:361364000") +AnnotationAssertion( "VHOG:0001445") +AnnotationAssertion( "Wikipedia:Pulmonary_alveolus") AnnotationAssertion(rdfs:label "alveolus of lung") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32508,6 +48231,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (myocardium of atrium) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0010493") "The atrial part of middle layer of the heart, comprised of involuntary muscle.") +AnnotationAssertion( "EFO:0003087") +AnnotationAssertion( "EMAPA:32746") +AnnotationAssertion( "FMA:83509") +AnnotationAssertion( "MA:0000081") +AnnotationAssertion( "SCTID:191910002") +AnnotationAssertion( "TAO:0001374") +AnnotationAssertion( "VHOG:0000602") +AnnotationAssertion( "ZFA:0001374") AnnotationAssertion(rdfs:label "myocardium of atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32516,6 +48248,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nucleus of brain) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A neural nucleus that is part of the brain.") +AnnotationAssertion( "EMAPA:35185") +AnnotationAssertion( "FMA:83840") +AnnotationAssertion( "MA:0000811") +AnnotationAssertion( "NCIT:C49346") +AnnotationAssertion( "SCTID:426465002") +AnnotationAssertion( "ZFA:0005575") AnnotationAssertion(rdfs:label "nucleus of brain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32523,6 +48262,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gray matter of spinal cord) +AnnotationAssertion(Annotation( "MP:0008503") "The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue.") +AnnotationAssertion( "BAMS:Scgrey") +AnnotationAssertion( "DHBA:146035048") +AnnotationAssertion( "EMAPA:35792") +AnnotationAssertion( "FMA:256580") +AnnotationAssertion( "MA:0000002") +AnnotationAssertion( "NCIT:C32696") +AnnotationAssertion( "NLXANAT:100204") +AnnotationAssertion( "SCTID:279441003") +AnnotationAssertion( "neuronames:2619") AnnotationAssertion(rdfs:label "gray matter of spinal cord") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32531,6 +48280,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (coelemic cavity lumen) +AnnotationAssertion(Annotation( "BTO:0001707") "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities.") +AnnotationAssertion( "AEO:0000186") +AnnotationAssertion( "BTO:0001707") +AnnotationAssertion( "EHDAA2:0000267") +AnnotationAssertion( "FMA:85006") +AnnotationAssertion( "NCIT:C25444") +AnnotationAssertion( "RETIRED_EHDAA2:0003186") +AnnotationAssertion( "SCTID:361348008") +AnnotationAssertion( "TAO:0001438") +AnnotationAssertion( "ZFA:0001438") +AnnotationAssertion( "galen:BodyCavity") +AnnotationAssertion(rdfs:comment "EDITOR_NOTE check the FMA placement here; ncit placement of body cavity here probably not correct") AnnotationAssertion(rdfs:label "coelemic cavity lumen") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32538,7 +48299,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (muscle of back) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a back [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35161") +AnnotationAssertion( "FMA:85216") +AnnotationAssertion( "MA:0000496") AnnotationAssertion(rdfs:label "muscle of back") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32547,6 +48311,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (notochord) +AnnotationAssertion(Annotation( "ISBN:0815318960") Annotation( "Wikipedia:Notochord") Annotation( "http://tolweb.org/Chordata/2499") Annotation( "https://github.com/obophenotype/uberon/issues/25") Annotation( "https://github.com/obophenotype/uberon/issues/271") "A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube.") +AnnotationAssertion( "AAO:0000327") +AnnotationAssertion( "BTO:0001768") +AnnotationAssertion( "CALOHA:TS-0690") +AnnotationAssertion( "EHDAA2:0001277") +AnnotationAssertion( "EHDAA:1241") +AnnotationAssertion( "EHDAA:6021") +AnnotationAssertion( "EMAPA:16191") +AnnotationAssertion( "EV:0100002") +AnnotationAssertion( "FMA:85521") +AnnotationAssertion( "GAID:1311") +AnnotationAssertion( "MAT:0000281") +AnnotationAssertion( "MESH:D009672") +AnnotationAssertion( "NCIT:C12463") +AnnotationAssertion( "SCTID:308820002") +AnnotationAssertion( "TAO:0000135") +AnnotationAssertion( "VHOG:0000199") +AnnotationAssertion( "VSAO:0000032") +AnnotationAssertion( "Wikipedia:Notochord") +AnnotationAssertion( "XAO:0000055") +AnnotationAssertion( "ZFA:0000135") +AnnotationAssertion( "http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg") +AnnotationAssertion(rdfs:comment "The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB]") AnnotationAssertion(rdfs:label "notochord") SubClassOf( ) SubClassOf( ) @@ -32563,6 +48350,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (somite) +AnnotationAssertion(Annotation( "DOI:10.1111/j.1439-0426.2012.01987.x") Annotation( "Wikipedia:Somite") "Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.") +AnnotationAssertion( "AAO:0010569") +AnnotationAssertion( "AEO:0001015") +AnnotationAssertion( "BTO:0001558") +AnnotationAssertion( "EHDAA2:0003436") +AnnotationAssertion( "EHDAA:366") +AnnotationAssertion( "EHDAA:699") +AnnotationAssertion( "EMAPA:31169") +AnnotationAssertion( "FMA:85522") +AnnotationAssertion( "GAID:1306") +AnnotationAssertion( "MAT:0000068") +AnnotationAssertion( "MESH:D019170") +AnnotationAssertion( "MIAA:0000068") +AnnotationAssertion( "NCIT:C34302") +AnnotationAssertion( "TAO:0000155") +AnnotationAssertion( "VHOG:0000191") +AnnotationAssertion( "Wikipedia:Somite") +AnnotationAssertion( "XAO:0000058") +AnnotationAssertion( "ZFA:0000155") +AnnotationAssertion(rdfs:comment "When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248]") AnnotationAssertion(rdfs:label "somite") SubClassOf( ) SubClassOf( ) @@ -32571,6 +48378,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (exocrine system) +AnnotationAssertion(Annotation( "Wikipedia:Exocrine_gland") "Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia].") +AnnotationAssertion( "CALOHA:TS-2057") +AnnotationAssertion( "EHDAA2:0002225") +AnnotationAssertion( "EMAPA:35329") +AnnotationAssertion( "FMA:85539") +AnnotationAssertion( "MA:0002411") +AnnotationAssertion( "NCIT:C12957") +AnnotationAssertion( "Wikipedia:Exocrine_gland") +AnnotationAssertion( "WikipediaCategory:Exocrine_system") AnnotationAssertion(rdfs:label "exocrine system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32579,12 +48395,21 @@ SubClassOf( ObjectSomeValuesFrom( DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) # Class: (pulmonary trunk) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An arterial trunk which is continuous with the heart and branches into the pulmonary arteries.") +AnnotationAssertion( "EHDAA2:0001576") +AnnotationAssertion( "EHDAA:9831") +AnnotationAssertion( "EMAPA:17015") +AnnotationAssertion( "FMA:8612") +AnnotationAssertion( "MA:0002033") +AnnotationAssertion( "NCIT:C116918") +AnnotationAssertion( "VHOG:0001134") +AnnotationAssertion( "galen:PulmonaryTrunk") AnnotationAssertion(rdfs:label "pulmonary trunk") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32593,6 +48418,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lamina propria of bronchus) +AnnotationAssertion(Annotation( "OBOL:automatic") "A lamina propria that is part of a bronchus [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35194") +AnnotationAssertion( "FMA:86619") +AnnotationAssertion( "MA:0001836") +AnnotationAssertion( "NCIT:C49212") AnnotationAssertion(rdfs:label "lamina propria of bronchus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32601,6 +48431,25 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural crest) +AnnotationAssertion(Annotation( "MP:0009846") "A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].") +AnnotationAssertion( "AAO:0010578") +AnnotationAssertion( "BTO:0001764") +AnnotationAssertion( "CALOHA:TS-0676") +AnnotationAssertion( "EHDAA2:0004419") +AnnotationAssertion( "EMAPA:32737") +AnnotationAssertion( "FMA:86666") +AnnotationAssertion( "GAID:1310") +AnnotationAssertion( "MAT:0000066") +AnnotationAssertion( "MESH:D009432") +AnnotationAssertion( "MIAA:0000066") +AnnotationAssertion( "NCIT:C34222") +AnnotationAssertion( "SCTID:361462002") +AnnotationAssertion( "VHOG:0000057") +AnnotationAssertion( "Wikipedia:Neural_crest") +AnnotationAssertion( "XAO:0000048") +AnnotationAssertion( "ZFA:0000045") +AnnotationAssertion( "neuronames:1366") +AnnotationAssertion(rdfs:comment "Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells.") AnnotationAssertion(rdfs:label "neural crest") SubClassOf( ) SubClassOf( ) @@ -32614,6 +48463,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdomen musculature) +AnnotationAssertion(Annotation( "OBOL:automatic") "Set of all muscles in abdomen.") +AnnotationAssertion( "FMA:71294") +AnnotationAssertion( "FMA:86917") +AnnotationAssertion( "TAO:0001327") +AnnotationAssertion( "ZFA:0001327") AnnotationAssertion(rdfs:label "abdomen musculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32621,7 +48475,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (descending thoracic aorta) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MP:0009868") "The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.") +AnnotationAssertion( "EFO:0002527") +AnnotationAssertion( "EMAPA:18605") +AnnotationAssertion( "FMA:87217") +AnnotationAssertion( "MA:0002572") +AnnotationAssertion( "SCTID:181301002") AnnotationAssertion(rdfs:label "descending thoracic aorta") SubClassOf( ) SubClassOf( ) @@ -32632,14 +48491,62 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neurectoderm) +AnnotationAssertion(Annotation( "Wikipedia:Neuroectoderm") "Embryonic ectoderm that gives rise to nervous tissue.") +AnnotationAssertion( "AAO:0011074") +AnnotationAssertion( "BILA:0000039") +AnnotationAssertion( "CALOHA:TS-1212") +AnnotationAssertion( "EHDAA2:0001248") +AnnotationAssertion( "EHDAA:1498") +AnnotationAssertion( "EHDAA:255") +AnnotationAssertion( "EMAPA:16073") +AnnotationAssertion( "EV:0100004") +AnnotationAssertion( "FMA:87657") +AnnotationAssertion( "MAT:0000176") +AnnotationAssertion( "MIAA:0000176") +AnnotationAssertion( "NCIT:C34228") +AnnotationAssertion( "TAO:0001120") +AnnotationAssertion( "VHOG:0000150") +AnnotationAssertion( "Wikipedia:Neuroectoderm") +AnnotationAssertion( "XAO:0000042") +AnnotationAssertion( "ZFA:0001120") AnnotationAssertion(rdfs:label "neurectoderm") SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (thoracic vertebra) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A thoracic vertebra endochondral element that is composed primarily of a bone tissue.") +AnnotationAssertion( "EMAPA:18011") +AnnotationAssertion( "FMA:9139") +AnnotationAssertion( "GAID:244") +AnnotationAssertion( "MA:0000314") +AnnotationAssertion( "MESH:D013904") +AnnotationAssertion( "NCIT:C12798") +AnnotationAssertion( "SCTID:181821009") +AnnotationAssertion( "Wikipedia:Thoracic_vertebrae") +AnnotationAssertion(rdfs:label "thoracic vertebra") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (epicardium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart.") +AnnotationAssertion( "AAO:0010409") +AnnotationAssertion( "EHDAA2:0002202") +AnnotationAssertion( "FMA:9461") +AnnotationAssertion( "NCIT:C13164") +AnnotationAssertion( "TAO:0005057") +AnnotationAssertion( "VHOG:0000119") +AnnotationAssertion( "Wikipedia:Epicardium") +AnnotationAssertion( "XAO:0000316") +AnnotationAssertion( "ZFA:0005057") +AnnotationAssertion( "galen:Epicardium") +AnnotationAssertion(rdfs:comment "EDITOR_NOTE TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer.") AnnotationAssertion(rdfs:label "epicardium") SubClassOf( ) SubClassOf( ) @@ -32650,6 +48557,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (myocardium) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0005329") "The middle layer of the heart, comprised mainly of striated cardiac muscle fibers.") +AnnotationAssertion( "AAO:0010410") +AnnotationAssertion( "BSA:0000089") +AnnotationAssertion( "BTO:0000901") +AnnotationAssertion( "CALOHA:TS-0440") +AnnotationAssertion( "EFO:0000819") +AnnotationAssertion( "EHDAA2:0004150") +AnnotationAssertion( "EV:0100022") +AnnotationAssertion( "FMA:9462") +AnnotationAssertion( "GAID:173") +AnnotationAssertion( "MA:0000164") +AnnotationAssertion( "MAT:0000453") +AnnotationAssertion( "MESH:D009206") +AnnotationAssertion( "NCIT:C12371") +AnnotationAssertion( "RETIRED_EHDAA2:0001220") +AnnotationAssertion( "SCTID:362012001") +AnnotationAssertion( "TAO:0001319") +AnnotationAssertion( "VHOG:0000083") +AnnotationAssertion( "Wikipedia:Myocardium") +AnnotationAssertion( "XAO:0000065") +AnnotationAssertion( "ZFA:0001319") +AnnotationAssertion( "galen:Myocardium") +AnnotationAssertion(rdfs:comment "EDITOR_NOTE TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium") AnnotationAssertion(rdfs:label "myocardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32660,6 +48590,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (conducting system of heart) +AnnotationAssertion(Annotation( "GO:0003161") "The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO].") +AnnotationAssertion( "EFO:0003909") +AnnotationAssertion( "EHDAA2:0004185") +AnnotationAssertion( "EMAPA:35428") +AnnotationAssertion( "EV:0100025") +AnnotationAssertion( "FMA:9476") +AnnotationAssertion( "MA:0000094") +AnnotationAssertion( "MESH:D006329") +AnnotationAssertion( "SCTID:281489000") +AnnotationAssertion( "TAO:0005063") +AnnotationAssertion( "VHOG:0001271") +AnnotationAssertion( "ZFA:0005063") AnnotationAssertion(rdfs:label "conducting system of heart") SubClassOf( ) SubClassOf( ) @@ -32672,7 +48614,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sinoatrial node) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0003163") Annotation( "Wikipedia:Sinoatrial_node") "The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA].") +AnnotationAssertion( "BTO:0004358") +AnnotationAssertion( "EHDAA2:0004184") +AnnotationAssertion( "EMAPA:35772") +AnnotationAssertion( "FMA:9477") +AnnotationAssertion( "GAID:561") +AnnotationAssertion( "MA:0000097") +AnnotationAssertion( "MESH:D012849") +AnnotationAssertion( "NCIT:C33555") +AnnotationAssertion( "SCTID:277687007") +AnnotationAssertion( "TAO:0005069") +AnnotationAssertion( "Wikipedia:Sinoatrial_node") +AnnotationAssertion( "ZFA:0005069") +AnnotationAssertion(rdfs:comment "WP:Heart states: \"The SA node is found in all amniotes but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous and the sinus venosus coordinates the beat which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is, instead, in the atrium.\". Note however that ZFA has SA node.") AnnotationAssertion(rdfs:label "sinoatrial node") SubClassOf( ) SubClassOf( ) @@ -32684,7 +48639,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (atrioventricular node) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "UBERON:cjm") Annotation( "Wikipedia:Atrioventricular_node") "An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles.") +AnnotationAssertion( "BTO:0005689") +AnnotationAssertion( "EFO:0000276") +AnnotationAssertion( "EHDAA2:0004183") +AnnotationAssertion( "EMAPA:35153") +AnnotationAssertion( "FMA:9478") +AnnotationAssertion( "GAID:558") +AnnotationAssertion( "MA:0000095") +AnnotationAssertion( "MAT:0000498") +AnnotationAssertion( "MESH:D001283") +AnnotationAssertion( "NCIT:C32161") +AnnotationAssertion( "SCTID:277688002") +AnnotationAssertion( "TAO:0005070") +AnnotationAssertion( "VHOG:0001474") +AnnotationAssertion( "Wikipedia:Atrioventricular_node") +AnnotationAssertion( "ZFA:0005070") AnnotationAssertion(rdfs:label "atrioventricular node") SubClassOf( ) SubClassOf( ) @@ -32696,6 +48666,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac Purkinje fiber) +AnnotationAssertion(Annotation( "GO:0003165") "The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.") +AnnotationAssertion( "BTO:0001735") +AnnotationAssertion( "EMAPA:35718") +AnnotationAssertion( "FMA:9492") +AnnotationAssertion( "GAID:560") +AnnotationAssertion( "MA:0000096") +AnnotationAssertion( "MESH:D011690") +AnnotationAssertion( "NCIT:C33430") +AnnotationAssertion( "Wikipedia:Purkinje_fiber") AnnotationAssertion(rdfs:label "cardiac Purkinje fiber") SubClassOf( ) SubClassOf( ) @@ -32705,6 +48684,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (serous pericardium) +AnnotationAssertion(Annotation( "Wikipedia:Serous_pericardium") Annotation( "http://orcid.org/0000-0002-6601-2165") "Serous membrane which is divided into parietal and visceral serous pericardium.") +AnnotationAssertion( "EMAPA:19030") +AnnotationAssertion( "FMA:9582") +AnnotationAssertion( "MA:0002739") +AnnotationAssertion( "SCTID:243954002") +AnnotationAssertion( "Wikipedia:Serous_pericardium") AnnotationAssertion(rdfs:label "serous pericardium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32714,6 +48699,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (peritoneum) +AnnotationAssertion(Annotation( "VHOG:0001257") "A serous membrane that lines the peritoneal cavity[VHOG,modified].") +AnnotationAssertion( "AAO:0010814") +AnnotationAssertion( "BTO:0001472") +AnnotationAssertion( "CALOHA:TS-2072") +AnnotationAssertion( "EV:0100087") +AnnotationAssertion( "FMA:9584") +AnnotationAssertion( "GAID:18") +AnnotationAssertion( "MA:0000449") +AnnotationAssertion( "MESH:D010537") +AnnotationAssertion( "NCIT:C12770") +AnnotationAssertion( "TAO:0005120") +AnnotationAssertion( "VHOG:0001257") +AnnotationAssertion( "Wikipedia:Peritoneum") +AnnotationAssertion( "XAO:0000139") +AnnotationAssertion( "ZFA:0005120") +AnnotationAssertion( "galen:Peritoneum") AnnotationAssertion(rdfs:label "peritoneum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32722,6 +48723,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (fibrous pericardium) +AnnotationAssertion(Annotation( "FMA:9586") "Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA].") +AnnotationAssertion( "EMAPA:19029") +AnnotationAssertion( "FMA:9586") +AnnotationAssertion( "MA:0002738") +AnnotationAssertion( "SCTID:243953008") +AnnotationAssertion( "Wikipedia:Fibrous_pericardium") AnnotationAssertion(rdfs:label "fibrous pericardium") SubClassOf( ) SubClassOf( ) @@ -32731,6 +48738,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (exocrine gland) +AnnotationAssertion(Annotation( "Wikipedia:Exocrine_gland") "A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas.") +AnnotationAssertion( "AEO:0000097") +AnnotationAssertion( "BTO:0000765") +AnnotationAssertion( "CALOHA:TS-2012") +AnnotationAssertion( "EHDAA2:0003097") +AnnotationAssertion( "EMAPA:35327") +AnnotationAssertion( "FMA:9596") +AnnotationAssertion( "GAID:34") +AnnotationAssertion( "MA:0002564") +AnnotationAssertion( "MESH:D005088") +AnnotationAssertion( "NCIT:C12712") +AnnotationAssertion( "SCTID:115976003") +AnnotationAssertion( "Wikipedia:Exocrine_gland") AnnotationAssertion(rdfs:label "exocrine gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32739,6 +48759,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endocrine gland) +AnnotationAssertion(Annotation( "Wikipedia:Endocrine_gland") "Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified].") +AnnotationAssertion( "AEO:0000098") +AnnotationAssertion( "BTO:0001488") +AnnotationAssertion( "CALOHA:TS-1300") +AnnotationAssertion( "EHDAA2:0003098") +AnnotationAssertion( "EMAPA:35999") +AnnotationAssertion( "FMA:9602") +AnnotationAssertion( "GAID:335") +AnnotationAssertion( "MA:0002563") +AnnotationAssertion( "MESH:D004702") +AnnotationAssertion( "NCIT:C12704") +AnnotationAssertion( "SCTID:40818001") +AnnotationAssertion( "Wikipedia:Endocrine_gland") AnnotationAssertion(rdfs:label "endocrine gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32747,7 +48780,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bone marrow) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MGI:cwg") Annotation( "MP:0002397") "The soft tissue that fills the cavities of bones.") +AnnotationAssertion( "AAO:0011007") +AnnotationAssertion( "BTO:0000141") +AnnotationAssertion( "BTO:0000829") +AnnotationAssertion( "CALOHA:TS-0087") +AnnotationAssertion( "EFO:0000868") +AnnotationAssertion( "EMAPA:32760") +AnnotationAssertion( "EV:0100046") +AnnotationAssertion( "FMA:9608") +AnnotationAssertion( "GAID:1287") +AnnotationAssertion( "MA:0000134") +AnnotationAssertion( "MAT:0000084") +AnnotationAssertion( "MESH:D001853") +AnnotationAssertion( "MIAA:0000084") +AnnotationAssertion( "NCIT:C12431") +AnnotationAssertion( "SCTID:421320006") +AnnotationAssertion( "VHOG:0001218") +AnnotationAssertion( "Wikipedia:Bone_marrow") +AnnotationAssertion( "XAO:0000123") +AnnotationAssertion( "galen:BoneMarrow") AnnotationAssertion(rdfs:label "bone marrow") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32760,7 +48812,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranial muscle) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any skeletal muscle that is part of the head region.") +AnnotationAssertion( "AAO:0000107") +AnnotationAssertion( "BTO:0000021") +AnnotationAssertion( "EFO:0003524") +AnnotationAssertion( "EHDAA2:0000322") +AnnotationAssertion( "EMAPA:18172") +AnnotationAssertion( "FMA:9616") +AnnotationAssertion( "MA:0000578") +AnnotationAssertion( "SCTID:244718003") +AnnotationAssertion( "ZFA:0001652") +AnnotationAssertion(rdfs:comment "defined generically so could in theory encompass FBbt:00003260 'skeletal muscle of head', or the muscle of a starfish Aristotle's lantern, but we restrict this to craniates. Skeletal muscles of the head originate from the non-segmented head mesoderm (Noden, 1983; Wachtler et al., 1984)") AnnotationAssertion(rdfs:label "cranial muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32771,7 +48833,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (muscle of neck) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any muscle that is part of the cervical (neck) region.") +AnnotationAssertion( "FMA:9617") +AnnotationAssertion( "GAID:149") +AnnotationAssertion( "MA:0000587") +AnnotationAssertion( "MESH:D009334") +AnnotationAssertion( "NCIT:C33163") AnnotationAssertion(rdfs:label "muscle of neck") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32779,7 +48846,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (muscle of abdomen) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Abdominal_muscle") "Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis.") +AnnotationAssertion( "BTO:0001261") +AnnotationAssertion( "EMAPA:35103") +AnnotationAssertion( "FMA:9620") +AnnotationAssertion( "GAID:89") +AnnotationAssertion( "MA:0000520") +AnnotationAssertion( "MESH:D000009") +AnnotationAssertion( "NCIT:C32040") +AnnotationAssertion( "SCTID:361352008") +AnnotationAssertion( "Wikipedia:Abdominal_muscle") AnnotationAssertion(rdfs:label "muscle of abdomen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32789,13 +48865,45 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (connective tissue) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000017") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "https://github.com/obophenotype/uberon/issues/23") "Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.") +AnnotationAssertion( "AAO:0000098") +AnnotationAssertion( "BTO:0000421") +AnnotationAssertion( "CALOHA:TS-2009") +AnnotationAssertion( "EFO:0000952") +AnnotationAssertion( "EMAPA:35251") +AnnotationAssertion( "FMA:9640") +AnnotationAssertion( "GAID:100") +AnnotationAssertion( "MA:0000011") +AnnotationAssertion( "MAT:0000301") +AnnotationAssertion( "MESH:D003238") +AnnotationAssertion( "MIAA:0000301") +AnnotationAssertion( "NCIT:C12374") +AnnotationAssertion( "SCTID:361919005") +AnnotationAssertion( "TAO:0001641") +AnnotationAssertion( "VSAO:0000017") +AnnotationAssertion( "XAO:0001017") +AnnotationAssertion( "ZFA:0001632") +AnnotationAssertion( "galen:ConnectiveTissue") AnnotationAssertion(rdfs:label "connective tissue") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (muscle tissue) +AnnotationAssertion(Annotation( "GO:0060537") Annotation( "Wikipedia:Muscle_tissue") Annotation( "https://sourceforge.net/tracker/index.php?func=detail&aid=2801266&group_id=36855&atid=440764") "Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].") +AnnotationAssertion( "AAO:0000306") +AnnotationAssertion( "AEO:0000122") +AnnotationAssertion( "CALOHA:TS-0642") +AnnotationAssertion( "EHDAA2:0003122") +AnnotationAssertion( "EMAPA:32715") +AnnotationAssertion( "FMA:9641") +AnnotationAssertion( "MA:0002437") +AnnotationAssertion( "MESH:D009132") +AnnotationAssertion( "NCIT:C12435") +AnnotationAssertion( "SCTID:91727004") +AnnotationAssertion( "Wikipedia:Muscle_tissue") +AnnotationAssertion( "galen:MuscleTissue") +AnnotationAssertion(rdfs:comment "Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach.") AnnotationAssertion(rdfs:label "muscle tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32808,7 +48916,26 @@ DisjointClasses( (hematopoietic system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Haematopoiesis") "Anatomical system that is involved in the production of hematopoietic cells.") +AnnotationAssertion( "AAO:0011002") +AnnotationAssertion( "BTO:0000570") +AnnotationAssertion( "CALOHA:TS-0449") +AnnotationAssertion( "EFO:0000798") +AnnotationAssertion( "EMAPA:35402") +AnnotationAssertion( "EV:0100045") +AnnotationAssertion( "FMA:9667") +AnnotationAssertion( "GAID:1008") +AnnotationAssertion( "MA:0002434") +AnnotationAssertion( "MAT:0000022") +AnnotationAssertion( "MESH:D006413") +AnnotationAssertion( "MIAA:0000022") +AnnotationAssertion( "NCIT:C12909") +AnnotationAssertion( "SCTID:362587009") +AnnotationAssertion( "TAO:0005023") +AnnotationAssertion( "VHOG:0001624") +AnnotationAssertion( "Wikipedia:Haematopoiesis") +AnnotationAssertion( "XAO:0000122") +AnnotationAssertion( "ZFA:0005023") AnnotationAssertion(rdfs:label "hematopoietic system") SubClassOf( ) SubClassOf( ) @@ -32817,11 +48944,68 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) DisjointClasses( ) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) +# Class: (bile duct) + +AnnotationAssertion(Annotation( "Wikipedia:Bile_duct") Annotation( "http://orcid.org/0000-0002-6601-2165") "Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine.") +AnnotationAssertion( "AAO:0011019") +AnnotationAssertion( "BTO:0000122") +AnnotationAssertion( "CALOHA:TS-0075") +AnnotationAssertion( "EMAPA:35171") +AnnotationAssertion( "EV:0100091") +AnnotationAssertion( "FMA:9706") +AnnotationAssertion( "GAID:280") +AnnotationAssertion( "MA:0000354") +AnnotationAssertion( "MESH:D001652") +AnnotationAssertion( "NCIT:C12376") +AnnotationAssertion( "SCTID:276157007") +AnnotationAssertion( "TAO:0001100") +AnnotationAssertion( "VHOG:0000212") +AnnotationAssertion( "Wikipedia:Bile_duct") +AnnotationAssertion( "XAO:0000134") +AnnotationAssertion( "ZFA:0001100") +AnnotationAssertion(rdfs:label "bile duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (vomer) + +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0000098") "The triangular flat bone of the nasal septum.") +AnnotationAssertion( "AAO:0000633") +AnnotationAssertion( "FMA:9710") +AnnotationAssertion( "MA:0001496") +AnnotationAssertion( "NCIT:C33888") +AnnotationAssertion( "SCTID:272678009") +AnnotationAssertion( "TAO:0000308") +AnnotationAssertion( "Wikipedia:Vomer") +AnnotationAssertion( "ZFA:0000308") +AnnotationAssertion(rdfs:label "vomer") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (parietal pleura) +AnnotationAssertion(Annotation( "UBERON:cjm") Annotation( "Wikipedia:Pulmonary_pleurae") "The outer serous membrane of the pulmonary pleural.") +AnnotationAssertion( "EMAPA:16776") +AnnotationAssertion( "FMA:9733") +AnnotationAssertion( "MA:0002488") +AnnotationAssertion( "NCIT:C33273") +AnnotationAssertion( "SCTID:361998003") +AnnotationAssertion( "VHOG:0001495") +AnnotationAssertion( "Wikipedia:Parietal_pleura") +AnnotationAssertion(rdfs:comment "the part of the pleura external to the visceral pleura. It lines the inner surface of the chest wall, covers the diaphragm, and is reflected over the structures occupying the middle of the thorax") AnnotationAssertion(rdfs:label "parietal pleura") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32833,7 +49017,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (visceral pleura) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "UBERON:cjm") Annotation( "Wikipedia:Pulmonary_pleurae") "The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs.") +AnnotationAssertion( "EHDAA2:0002205") +AnnotationAssertion( "EMAPA:16777") +AnnotationAssertion( "FMA:9734") +AnnotationAssertion( "MA:0002489") +AnnotationAssertion( "NCIT:C33881") +AnnotationAssertion( "SCTID:361997008") +AnnotationAssertion( "VHOG:0001496") AnnotationAssertion(rdfs:label "visceral pleura") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32846,6 +49037,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pleural cavity) +AnnotationAssertion(Annotation( "Wikipedia:Pleural_cavity") Annotation( "https://github.com/obophenotype/uberon/issues/86") "The fluid-filled cavity that lies between the visceral and parietal pleurae.") +AnnotationAssertion( "BTO:0004422") +AnnotationAssertion( "EHDAA2:0001475") +AnnotationAssertion( "EMAPA:16773") +AnnotationAssertion( "EMAPA:16774") +AnnotationAssertion( "FMA:9740") +AnnotationAssertion( "GAID:95") +AnnotationAssertion( "MA:0000055") +AnnotationAssertion( "MESH:D035422") +AnnotationAssertion( "NCIT:C12840") +AnnotationAssertion( "SCTID:361999006") +AnnotationAssertion( "VHOG:0000581") +AnnotationAssertion( "Wikipedia:Pleural_cavity") AnnotationAssertion(rdfs:label "pleural cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32856,18 +49060,37 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (immune system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Immune_system") "Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies.") +AnnotationAssertion( "AAO:0011003") +AnnotationAssertion( "BILA:0000104") +AnnotationAssertion( "BTO:0005810") +AnnotationAssertion( "FMA:9825") +AnnotationAssertion( "GAID:328") +AnnotationAssertion( "MA:0002711") +AnnotationAssertion( "MESH:D007107") +AnnotationAssertion( "NCIT:C12735") +AnnotationAssertion( "SCTID:362590003") +AnnotationAssertion( "TAO:0001159") +AnnotationAssertion( "VHOG:0001247") +AnnotationAssertion( "Wikipedia:Immune_system") +AnnotationAssertion( "XAO:0003152") +AnnotationAssertion( "ZFA:0001159") AnnotationAssertion(rdfs:label "immune system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) DisjointClasses( ) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) # Class: (pericardial sac) +AnnotationAssertion(Annotation( "Wikipedia:Pericardium") Annotation( "https://github.com/obophenotype/uberon/issues/86") "A double-walled sac containing the heart and the roots of the great vessels.") +AnnotationAssertion( "FMA:9868") +AnnotationAssertion( "RETIRED_EHDAA2:0001443") +AnnotationAssertion( "SCTID:361326002") AnnotationAssertion(rdfs:label "pericardial sac") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32879,7 +49102,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pericardium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Pericardium") Annotation( "http://orcid.org/0000-0002-6601-2165") "The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium.") +AnnotationAssertion( "AAO:0010817") +AnnotationAssertion( "BSA:0000090") +AnnotationAssertion( "BTO:0000717") +AnnotationAssertion( "CALOHA:TS-0761") +AnnotationAssertion( "EFO:0000820") +AnnotationAssertion( "EHDAA:5376") +AnnotationAssertion( "EV:0100023") +AnnotationAssertion( "FMA:9869") +AnnotationAssertion( "GAID:569") +AnnotationAssertion( "MA:0000099") +AnnotationAssertion( "MAT:0000454") +AnnotationAssertion( "MESH:D010496") +AnnotationAssertion( "NCIT:C13005") +AnnotationAssertion( "RETIRED_EHDAA2:0001443") +AnnotationAssertion( "SCTID:181295003") +AnnotationAssertion( "VHOG:0001280") +AnnotationAssertion( "Wikipedia:Pericardium") +AnnotationAssertion( "XAO:0004182") +AnnotationAssertion( "ZFA:0000054") +AnnotationAssertion( "galen:Pericardium") AnnotationAssertion(rdfs:label "pericardium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32889,6 +49132,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (parietal serous pericardium) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac.") +AnnotationAssertion( "EHDAA:3422") +AnnotationAssertion( "EHDAA:5378") +AnnotationAssertion( "EMAPA:19031") +AnnotationAssertion( "FMA:9870") +AnnotationAssertion( "MA:0000483") +AnnotationAssertion( "NCIT:C94500") +AnnotationAssertion( "SCTID:243956000") +AnnotationAssertion( "VHOG:0000537") +AnnotationAssertion( "Wikipedia:Parietal_pericardium") AnnotationAssertion(rdfs:label "parietal serous pericardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32896,6 +49149,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pericardial fluid) +AnnotationAssertion(Annotation( "FMA:9887") Annotation( "Wikipedia:Pericardial_fluid") "Transudate contained in the pericardial cavity.[FMA].") +AnnotationAssertion( "BTO:0001016") +AnnotationAssertion( "FMA:9887") +AnnotationAssertion( "MA:0002530") +AnnotationAssertion( "Wikipedia:Pericardial_fluid") AnnotationAssertion(rdfs:label "pericardial fluid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32905,32 +49163,171 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (autonomic nervous system) +AnnotationAssertion(Annotation( "GO:0048483") "The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO].") +AnnotationAssertion( "AAO:0000033") +AnnotationAssertion( "BIRNLEX:1123") +AnnotationAssertion( "BTO:0002507") +AnnotationAssertion( "CALOHA:TS-2001") +AnnotationAssertion( "EHDA:10095") +AnnotationAssertion( "EHDAA2:0000158") +AnnotationAssertion( "EHDAA:3767") +AnnotationAssertion( "EMAPA:16984") +AnnotationAssertion( "FMA:65553") +AnnotationAssertion( "GAID:706") +AnnotationAssertion( "MA:0000219") +AnnotationAssertion( "MESH:D001341") +AnnotationAssertion( "NCIT:C12673") +AnnotationAssertion( "SCTID:362481007") +AnnotationAssertion( "TAO:0001574") +AnnotationAssertion( "VHOG:0000396") +AnnotationAssertion( "Wikipedia:Autonomic_nervous_system") +AnnotationAssertion( "ZFA:0001574") +AnnotationAssertion( "neuronames:2054") AnnotationAssertion(rdfs:label "autonomic nervous system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (vertebra) + +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "VSAO:0000184") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "http://orcid.org/0000-0002-6601-2165") "The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.") +AnnotationAssertion( "AAO:0000691") +AnnotationAssertion( "CALOHA:TS-2352") +AnnotationAssertion( "EFO:0001371") +AnnotationAssertion( "EMAPA:32740") +AnnotationAssertion( "FMA:9914") +AnnotationAssertion( "MA:0000309") +AnnotationAssertion( "NCIT:C12933") +AnnotationAssertion( "SCTID:181817002") +AnnotationAssertion( "TAO:0001189") +AnnotationAssertion( "Wikipedia:Vertebra") +AnnotationAssertion( "XAO:0004019") +AnnotationAssertion( "ZFA:0001189") +AnnotationAssertion( "galen:Vertebra") +AnnotationAssertion(rdfs:label "vertebra") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (cervical vertebra) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A vertebra that is located in the cervical region of the vertebral column.") +AnnotationAssertion( "EMAPA:17674") +AnnotationAssertion( "FMA:9915") +AnnotationAssertion( "GAID:235") +AnnotationAssertion( "MA:0000311") +AnnotationAssertion( "MESH:D002574") +AnnotationAssertion( "NCIT:C12693") +AnnotationAssertion( "SCTID:181820005") +AnnotationAssertion( "Wikipedia:Cervical_vertebrae") +AnnotationAssertion( "XAO:0003076") +AnnotationAssertion( "galen:CervicalVertebra") +AnnotationAssertion(rdfs:label "cervical vertebra") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (tail) + +AnnotationAssertion(Annotation( "AEO:0000109") Annotation( "Wikipedia:Tail") "An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail.") +AnnotationAssertion( "AEO:0000109") +AnnotationAssertion( "BILA:0000117") +AnnotationAssertion( "BTO:0001348") +AnnotationAssertion( "EFO:0000963") +AnnotationAssertion( "EHDAA:9198") +AnnotationAssertion( "GAID:1245") +AnnotationAssertion( "MAT:0000094") +AnnotationAssertion( "MESH:D013623") +AnnotationAssertion( "MIAA:0000094") +AnnotationAssertion( "WBbt:0005741") +AnnotationAssertion( "Wikipedia:Tail") +AnnotationAssertion(rdfs:label "tail") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (integumental system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0002001") Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/29") "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle.") +AnnotationAssertion( "AEO:0000154") +AnnotationAssertion( "BILA:0000118") +AnnotationAssertion( "CALOHA:TS-1299") +AnnotationAssertion( "CARO:0002001") +AnnotationAssertion( "EFO:0000807") +AnnotationAssertion( "EHDAA2:0000836") +AnnotationAssertion( "EHDAA2_RETIRED:0003154") +AnnotationAssertion( "EHDAA:6520") +AnnotationAssertion( "EMAPA:17524") +AnnotationAssertion( "EV:0100151") +AnnotationAssertion( "FMA:72979") +AnnotationAssertion( "HAO:0000421") +AnnotationAssertion( "MA:0000014") +AnnotationAssertion( "MAT:0000033") +AnnotationAssertion( "MESH:D034582") +AnnotationAssertion( "MIAA:0000033") +AnnotationAssertion( "NCIT:C12907") +AnnotationAssertion( "SCTID:361692004") +AnnotationAssertion( "TADS:0000108") +AnnotationAssertion( "VHOG:0000403") +AnnotationAssertion( "Wikipedia:Integumentary_system") +AnnotationAssertion( "XAO:0000176") +AnnotationAssertion( "galen:Surface") AnnotationAssertion(rdfs:label "integumental system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +DisjointClasses( ) DisjointClasses( ) DisjointClasses( ) # Class: (abdominal segment of trunk) +AnnotationAssertion(Annotation( "Wikipedia:Lumbar") "The abdominal segment of the torso.") +AnnotationAssertion( "EMAPA:35104") +AnnotationAssertion( "FMA:259211") +AnnotationAssertion( "MA:0000021") +AnnotationAssertion( "SCTID:362875007") +AnnotationAssertion( "Wikipedia:Lumbar") AnnotationAssertion(rdfs:label "abdominal segment of trunk") SubClassOf( ) SubClassOf( ) # Class: (cartilage tissue) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000040") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "https://github.com/obophenotype/uberon/issues/37") Annotation( "https://sourceforge.net/p/obo/vertebrate-skeletal-anatomy-vsao-term-requests/5") "Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.") +AnnotationAssertion( "AAO:0000060") +AnnotationAssertion( "AEO:0000087") +AnnotationAssertion( "BTO:0000206") +AnnotationAssertion( "EFO:0000949") +AnnotationAssertion( "EHDAA2:0003087") +AnnotationAssertion( "EMAPA:32730") +AnnotationAssertion( "EV:0100141") +AnnotationAssertion( "FMA:37377") +AnnotationAssertion( "GAID:99") +AnnotationAssertion( "MA:0000104") +AnnotationAssertion( "MAT:0000189") +AnnotationAssertion( "MESH:D002356") +AnnotationAssertion( "MIAA:0000189") +AnnotationAssertion( "NCIT:C12373") +AnnotationAssertion( "NCIT:C32268") +AnnotationAssertion( "SCTID:309312004") +AnnotationAssertion( "TAO:0001501") +AnnotationAssertion( "VHOG:0001207") +AnnotationAssertion( "VSAO:0000040") +AnnotationAssertion( "Wikipedia:Cartilage") +AnnotationAssertion( "XAO:0000170") +AnnotationAssertion( "ZFA:0005622") +AnnotationAssertion( "galen:Cartilage") +AnnotationAssertion(rdfs:comment "Previous: \"A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten].\" See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W]") AnnotationAssertion(rdfs:label "cartilage tissue") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -32940,6 +49337,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin gland) +AnnotationAssertion(Annotation( "OBOL:automatic") "A gland that is part of a skin of body [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35774") +AnnotationAssertion( "FMA:71878") +AnnotationAssertion( "MA:0000146") +AnnotationAssertion( "SCTID:110485007") AnnotationAssertion(rdfs:label "skin gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32947,8 +49349,53 @@ SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepatobiliary system) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The part of the digestive system that contains the liver and the biliary system.") +AnnotationAssertion( "AAO:0011056") +AnnotationAssertion( "CALOHA:TS-1308") +AnnotationAssertion( "EFO:0000800") +AnnotationAssertion( "EHDAA2:0000998") +AnnotationAssertion( "EHDAA:2189") +AnnotationAssertion( "EMAPA:16840") +AnnotationAssertion( "EV:0100088") +AnnotationAssertion( "MA:0000324") +AnnotationAssertion( "MAT:0000024") +AnnotationAssertion( "MIAA:0000024") +AnnotationAssertion( "NCIT:C43612") +AnnotationAssertion( "TAO:0000036") +AnnotationAssertion( "VHOG:0000294") +AnnotationAssertion( "Wikipedia:Hepatobiliary_system") +AnnotationAssertion( "XAO:0000132") +AnnotationAssertion( "ZFA:0000036") +AnnotationAssertion(rdfs:label "hepatobiliary system") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +DisjointClasses( ) +DisjointClasses( ) + # Class: (oral epithelium) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues.") +AnnotationAssertion( "AAO:0010357") +AnnotationAssertion( "BTO:0001775") +AnnotationAssertion( "CALOHA:TS-0715") +AnnotationAssertion( "EHDAA2:0001325") +AnnotationAssertion( "EHDAA:2187") +AnnotationAssertion( "EMAPA:16839") +AnnotationAssertion( "EMAPA:26942") +AnnotationAssertion( "FMA:265152") +AnnotationAssertion( "MA:0000344") +AnnotationAssertion( "NCIT:C49595") +AnnotationAssertion( "TAO:0000816") +AnnotationAssertion( "VHOG:0000187") +AnnotationAssertion( "XAO:0003201") +AnnotationAssertion( "ZFA:0000816") AnnotationAssertion(rdfs:label "oral epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32958,6 +49405,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (visceral serous pericardium) +AnnotationAssertion(Annotation( "Wikipedia:Visceral_pericardium") "Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA].") +AnnotationAssertion( "EMAPA:19032") +AnnotationAssertion( "FMA:84882") +AnnotationAssertion( "MA:0000484") +AnnotationAssertion( "SCTID:243955001") +AnnotationAssertion( "VHOG:0000538") +AnnotationAssertion( "Wikipedia:Visceral_pericardium") AnnotationAssertion(rdfs:label "visceral serous pericardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32968,6 +49422,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (choroidal blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a choroid [Automatically generated definition].") +AnnotationAssertion( "EMAPA:17828") +AnnotationAssertion( "FMA:76550") +AnnotationAssertion( "MA:0001237") +AnnotationAssertion(rdfs:comment "cannot find singular in FMA, using Set class") AnnotationAssertion(rdfs:label "choroidal blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32976,19 +49435,61 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (intersomitic artery) +AnnotationAssertion(Annotation( "MP:0010662") "The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries.") +AnnotationAssertion( "EHDAA2:0000882") +AnnotationAssertion( "EHDAA:4340") +AnnotationAssertion( "EMAPA:17616") +AnnotationAssertion( "MA:0001985") +AnnotationAssertion( "SCTID:360401001") +AnnotationAssertion( "TAO:0001061") +AnnotationAssertion( "VHOG:0000225") +AnnotationAssertion( "XAO:0004165") +AnnotationAssertion( "ZFA:0001061") AnnotationAssertion(rdfs:label "intersomitic artery") SubClassOf( ) SubClassOf( ) # Class: (spinal artery) +AnnotationAssertion(Annotation( "Wikipedia:Spinal_artery") Annotation( "https://orcid.org/0000-0002-6601-2165") "Arteries that supply the spinal cord.") +AnnotationAssertion( "EHDAA2:0001890") +AnnotationAssertion( "EHDAA:4355") +AnnotationAssertion( "EMAPA:18241") +AnnotationAssertion( "MA:0002043") +AnnotationAssertion( "NCIT:C33587") +AnnotationAssertion( "SCTID:244228006") +AnnotationAssertion( "TAO:0000682") +AnnotationAssertion( "Wikipedia:Spinal_artery") +AnnotationAssertion( "ZFA:0000682") AnnotationAssertion(rdfs:label "spinal artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (intestine secretion) + +AnnotationAssertion(Annotation( "Wikipedia:Succus_entericus") "Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine.") +AnnotationAssertion( "BTO:0000644") +AnnotationAssertion( "FMA:62974") +AnnotationAssertion( "GAID:1162") +AnnotationAssertion( "MA:0002515") +AnnotationAssertion( "MESH:D007419") +AnnotationAssertion( "NCIT:C32875") +AnnotationAssertion( "Wikipedia:Succus_entericus") +AnnotationAssertion(rdfs:label "intestine secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (esophagus mucosa) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a esophagus [Automatically generated definition].") +AnnotationAssertion( "BTO:0002859") +AnnotationAssertion( "EMAPA:26981") +AnnotationAssertion( "FMA:62996") +AnnotationAssertion( "MA:0002680") +AnnotationAssertion( "NCIT:C32538") +AnnotationAssertion( "SCTID:362127004") AnnotationAssertion(rdfs:label "esophagus mucosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -32996,6 +49497,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bone tissue) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000047") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.") +AnnotationAssertion( "CALOHA:TS-2011") +AnnotationAssertion( "EMAPA:35179") +AnnotationAssertion( "FMA:224804") +AnnotationAssertion( "MA:0002780") +AnnotationAssertion( "MESH:D001842") +AnnotationAssertion( "NCIT:C13076") +AnnotationAssertion( "VSAO:0000047") +AnnotationAssertion( "Wikipedia:Bone_tissue") +AnnotationAssertion( "XAO:0004040") +AnnotationAssertion( "ZFA:0005621") +AnnotationAssertion( "galen:BoneTissue") AnnotationAssertion(rdfs:label "bone tissue") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33004,7 +49517,10 @@ DisjointClasses( (iris epithelium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a iris [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35447") +AnnotationAssertion( "FMA:58517") +AnnotationAssertion( "MA:0002826") AnnotationAssertion(rdfs:label "iris epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33013,8 +49529,32 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (trabecula carnea) + +AnnotationAssertion(Annotation( "MGI:monikat") Annotation( "MP:0004067") "The supporting bundles of muscular fibers lining the walls of the ventricles of the heart.") +AnnotationAssertion( "EMAPA:18626") +AnnotationAssertion( "FMA:7269") +AnnotationAssertion( "MA:0002831") +AnnotationAssertion( "SCTID:118755002") +AnnotationAssertion( "Wikipedia:Trabeculae_carneae") +AnnotationAssertion(rdfs:label "trabecula carnea") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (endochondral bone) +AnnotationAssertion(Annotation( "GO:0001958") Annotation( "GO_REF:0000034") Annotation( "VSAO:0000145") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "https://github.com/obophenotype/uberon/issues/54") "Replacement bone that forms within cartilage.") +AnnotationAssertion( "AAO:0010776") +AnnotationAssertion( "AEO:0000083") +AnnotationAssertion( "BTO:0002157") +AnnotationAssertion( "EHDAA2:0003083") +AnnotationAssertion( "FMA:24321") +AnnotationAssertion( "TAO:0001591") +AnnotationAssertion( "VSAO:0000145") +AnnotationAssertion( "XAO:0004018") +AnnotationAssertion( "ZFA:0001591") AnnotationAssertion(rdfs:label "endochondral bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33024,13 +49564,43 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (intramembranous bone) +AnnotationAssertion(Annotation( "GO:0001957") Annotation( "Wikipedia:Intramembranous_ossification") Annotation( "https://github.com/obophenotype/uberon/issues/267") "Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].") +AnnotationAssertion( "EMAPA:36615") +AnnotationAssertion( "TAO:0001644") +AnnotationAssertion( "Wikipedia:Intramembranous_ossification") +AnnotationAssertion( "ZFA:0001635") AnnotationAssertion(rdfs:label "intramembranous bone") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (basicranium) + +AnnotationAssertion(Annotation( "Wikipedia:Base_of_skull") "The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof.") +AnnotationAssertion( "FMA:52801") +AnnotationAssertion( "MA:0002840") +AnnotationAssertion( "MESH:D019291") +AnnotationAssertion( "MFMO:0000044") +AnnotationAssertion( "NCIT:C12493") +AnnotationAssertion( "SCTID:181890004") +AnnotationAssertion( "Wikipedia:Base_of_skull") +AnnotationAssertion(rdfs:comment "The skull base is formed from a series of cartilages either side of, and rostral to, the notochord, whose tip lies just caudal to the pituitary gland. It is closely associated with the sensory capsules, which partially or completely sur- round the olfactory epithelium, the eye, and the inner ear[PMID:11523816]") +AnnotationAssertion(rdfs:label "basicranium") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (elastic tissue) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Connective tissue composed of elastic fibers.") +AnnotationAssertion( "FMA:20113") +AnnotationAssertion( "GAID:926") +AnnotationAssertion( "MA:0002853") +AnnotationAssertion( "MESH:D004547") +AnnotationAssertion( "NCIT:C32495") +AnnotationAssertion( "SCTID:27197004") +AnnotationAssertion( "Wikipedia:Elastic_fiber") AnnotationAssertion(rdfs:label "elastic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33039,6 +49609,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tunica media) +AnnotationAssertion(Annotation( "Wikipedia:Tunica_media") "The middle layer of an artery or vein. [WP,unvetted].") +AnnotationAssertion( "BTO:0002011") +AnnotationAssertion( "EMAPA:36298") +AnnotationAssertion( "FMA:55590") +AnnotationAssertion( "GAID:170") +AnnotationAssertion( "MA:0002855") +AnnotationAssertion( "MESH:D017540") +AnnotationAssertion( "NCIT:C33821") +AnnotationAssertion( "SCTID:61695000") +AnnotationAssertion( "Wikipedia:Tunica_media") +AnnotationAssertion(rdfs:comment "May be composed of smooth muscle and elastic tissue") AnnotationAssertion(rdfs:label "tunica media") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33047,6 +49628,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tunica intima) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "NCIT:C33820") Annotation( "Wikipedia:Tunica_intima") "The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong].") +AnnotationAssertion( "BTO:0002012") +AnnotationAssertion( "EMAPA:36297") +AnnotationAssertion( "FMA:55589") +AnnotationAssertion( "GAID:523") +AnnotationAssertion( "MA:0002861") +AnnotationAssertion( "MESH:D017539") +AnnotationAssertion( "NCIT:C33820") +AnnotationAssertion( "SCTID:8361002") +AnnotationAssertion( "SCTID:87483006") +AnnotationAssertion( "Wikipedia:Tunica_intima") AnnotationAssertion(rdfs:label "tunica intima") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33055,6 +49647,25 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gland) +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0002163") "An organ that functions as a secretory or excretory organ.") +AnnotationAssertion( "AAO:0000212") +AnnotationAssertion( "AEO:0000096") +AnnotationAssertion( "BTO:0000522") +AnnotationAssertion( "EFO:0000797") +AnnotationAssertion( "EHDAA2:0003096") +AnnotationAssertion( "EHDAA:2161") +AnnotationAssertion( "EMAPA:18425") +AnnotationAssertion( "FMA:7146") +AnnotationAssertion( "FMA:86294") +AnnotationAssertion( "HAO:0000375") +AnnotationAssertion( "MA:0003038") +AnnotationAssertion( "MAT:0000021") +AnnotationAssertion( "MIAA:0000021") +AnnotationAssertion( "NCIT:C13319") +AnnotationAssertion( "SCTID:134358001") +AnnotationAssertion( "Wikipedia:Gland") +AnnotationAssertion( "WikipediaCategory:Glands") +AnnotationAssertion( "galen:Gland") AnnotationAssertion(rdfs:label "gland") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33063,12 +49674,46 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epiblast (generic)) +AnnotationAssertion(Annotation( "Wikipedia:Epiblast") Annotation( "ZFIN:curator") "In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA].") +AnnotationAssertion( "BTO:0004593") +AnnotationAssertion( "FMA:296704") +AnnotationAssertion( "MAT:0000067") +AnnotationAssertion( "MIAA:0000067") +AnnotationAssertion( "VHOG:0000243") +AnnotationAssertion( "Wikipedia:Epiblast") AnnotationAssertion(rdfs:label "epiblast (generic)") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (post-anal tail bud) + +AnnotationAssertion(Annotation( "BTO:0001445") "The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node.") +AnnotationAssertion( "AAO:0011104") +AnnotationAssertion( "BTO:0001445") +AnnotationAssertion( "EFO:0002748") +AnnotationAssertion( "EHDAA2:0001976") +AnnotationAssertion( "EHDAA:1595") +AnnotationAssertion( "EMAPA:16580") +AnnotationAssertion( "MAT:0000070") +AnnotationAssertion( "MIAA:0000070") +AnnotationAssertion( "TAO:0000077") +AnnotationAssertion( "VHOG:0000201") +AnnotationAssertion( "XAO:0000107") +AnnotationAssertion( "ZFA:0000077") +AnnotationAssertion(rdfs:label "post-anal tail bud") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (arthropod sensillum) +AnnotationAssertion(Annotation( "FBbt:00007152") Annotation( "Wikipedia:Sensillum") "Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt].") +AnnotationAssertion( "BTO:0001237") +AnnotationAssertion( "EFO:0000939") +AnnotationAssertion( "HAO:0000933") +AnnotationAssertion( "MAT:0000163") +AnnotationAssertion( "MIAA:0000163") +AnnotationAssertion( "TGMA:0000540") +AnnotationAssertion( "Wikipedia:Sensillum") AnnotationAssertion(rdfs:label "arthropod sensillum") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33076,6 +49721,24 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch) +AnnotationAssertion(Annotation( "PMID:16313389") Annotation( "ZFA:yb") Annotation( "http://orcid.org/0000-0002-6601-2165") "One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches.") +AnnotationAssertion( "AAO:0010359") +AnnotationAssertion( "BTO:0001785") +AnnotationAssertion( "EFO:0000959") +AnnotationAssertion( "EHDAA:571") +AnnotationAssertion( "EMAPA:16117") +AnnotationAssertion( "FMA:293015") +AnnotationAssertion( "GAID:1292") +AnnotationAssertion( "MAT:0000242") +AnnotationAssertion( "MESH:D001934") +AnnotationAssertion( "MIAA:0000242") +AnnotationAssertion( "NCIT:C34249") +AnnotationAssertion( "SCTID:308766004") +AnnotationAssertion( "TAO:0001306") +AnnotationAssertion( "VHOG:0000155") +AnnotationAssertion( "Wikipedia:Pharyngeal_arch") +AnnotationAssertion( "XAO:0000096") +AnnotationAssertion( "ZFA:0001306") AnnotationAssertion(rdfs:label "pharyngeal arch") SubClassOf( ) SubClassOf( ) @@ -33087,6 +49750,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranial placode) +AnnotationAssertion(Annotation( "http://www.ncbi.nlm.nih.gov/books/NBK53175/") Annotation( "https://github.com/obophenotype/uberon/issues/135") Annotation( "https://github.com/seger/aao/issues/4") Annotation( "https://orcid.org/0000-0002-6601-2165") Annotation( "https://sourceforge.net/p/obo/xenopus-anatomy-xao-term-requests/11/") "Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic.") +AnnotationAssertion( "AAO:0010466") +AnnotationAssertion( "EFO:0001650") +AnnotationAssertion( "MAT:0000369") +AnnotationAssertion( "MIAA:0000369") +AnnotationAssertion( "XAO:0000305") AnnotationAssertion(rdfs:label "cranial placode") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33094,12 +49763,42 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anatomical cavity) +AnnotationAssertion(Annotation( "FMA:67552") "Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina.") +AnnotationAssertion( "BIRNLEX:1011") +AnnotationAssertion( "FMA:67552") +AnnotationAssertion( "MA:0002447") +AnnotationAssertion( "NCIT:C34007") +AnnotationAssertion( "galen:Cavity") AnnotationAssertion(rdfs:label "anatomical cavity") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (organ cavity) + +AnnotationAssertion( "BIRNLEX:1019") +AnnotationAssertion( "FMA:12237") +AnnotationAssertion( "SCTID:362606005") +AnnotationAssertion(rdfs:label "organ cavity") +SubClassOf( ) + +# Class: (lumen of central nervous system) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube.") +AnnotationAssertion( "BIRNLEX:1029") +AnnotationAssertion( "FMA:75007") +AnnotationAssertion(rdfs:label "lumen of central nervous system") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (regional part of brain) +AnnotationAssertion(Annotation( "BIRNLEX:1167") "Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia.") +AnnotationAssertion( "BIRNLEX:1167") +AnnotationAssertion( "FMA:55676") +AnnotationAssertion( "NCIT:C13031") +AnnotationAssertion( "SCTID:384763002") AnnotationAssertion(rdfs:label "regional part of brain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33109,7 +49808,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cervical spinal cord) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A spinal cord segment that adjacent_to a cervical region.") +AnnotationAssertion( "BIRNLEX:1499") +AnnotationAssertion( "FMA:71166") +AnnotationAssertion( "MA:0003081") +AnnotationAssertion( "NCIT:C12892") +AnnotationAssertion( "SCTID:180960003") +AnnotationAssertion( "neuronames:1654") AnnotationAssertion(rdfs:label "cervical spinal cord") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33118,6 +49823,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trigeminal nucleus) +AnnotationAssertion(Annotation( "OBOL:automatic") "A nucleus of brain that is part of a trigeminal nuclear complex.") +AnnotationAssertion( "BM:V") +AnnotationAssertion( "BTO:0001074") +AnnotationAssertion( "CALOHA:TS-2077") +AnnotationAssertion( "EMAPA:35883") +AnnotationAssertion( "EV:0100271") +AnnotationAssertion( "FMA:71247") +AnnotationAssertion( "GAID:604") +AnnotationAssertion( "MA:0001028") +AnnotationAssertion( "MESH:D014278") +AnnotationAssertion( "NCIT:C12807") +AnnotationAssertion( "SCTID:280164007") +AnnotationAssertion( "VHOG:0001353") +AnnotationAssertion( "http://uri.neuinfo.org/nif/nifstd/nifext_11") AnnotationAssertion(rdfs:label "trigeminal nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33126,7 +49845,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pontine tegmentum) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "BIRNLEX:923") "Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133).") +AnnotationAssertion( "BAMS:PTg") +AnnotationAssertion( "BIRNLEX:923") +AnnotationAssertion( "DHBA:12416") +AnnotationAssertion( "FMA:71108") +AnnotationAssertion( "HBA:9135") +AnnotationAssertion( "SCTID:362401009") +AnnotationAssertion( "Wikipedia:Pontine_tegmentum") AnnotationAssertion(rdfs:label "pontine tegmentum") SubClassOf( ) SubClassOf( ) @@ -33138,13 +49864,25 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (septum) +AnnotationAssertion(Annotation( "Wikipedia:Septum") "A wall, dividing a cavity or structure into smaller ones[WP].") +AnnotationAssertion( "AAO:0011127") +AnnotationAssertion( "FMA:86461") +AnnotationAssertion( "Wikipedia:Septum") +AnnotationAssertion(rdfs:comment "general anatomical term in FMA") AnnotationAssertion(rdfs:label "septum") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (thoracic spinal cord) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Thoracic_spinal_cord") "The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted].") +AnnotationAssertion( "BIRNLEX:966") +AnnotationAssertion( "FMA:71167") +AnnotationAssertion( "MA:0003082") +AnnotationAssertion( "NCIT:C12894") +AnnotationAssertion( "SCTID:278750009") +AnnotationAssertion( "Wikipedia:Thoracic_spinal_cord") +AnnotationAssertion( "neuronames:1718") AnnotationAssertion(rdfs:label "thoracic spinal cord") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33152,6 +49890,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (midbrain-hindbrain boundary) +AnnotationAssertion(Annotation( "GO:0021555") "The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate.") +AnnotationAssertion( "AAO:0011064") +AnnotationAssertion( "DMBA:16810") +AnnotationAssertion( "EHDAA2:0004395") +AnnotationAssertion( "EHDAA:5789") +AnnotationAssertion( "EMAPA:32857") +AnnotationAssertion( "NCIT:C93172") +AnnotationAssertion( "TAO:0000042") +AnnotationAssertion( "VHOG:0000649") +AnnotationAssertion( "XAO:0000016") +AnnotationAssertion( "ZFA:0000042") +AnnotationAssertion( "neuronames:2076") AnnotationAssertion(rdfs:label "midbrain-hindbrain boundary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33163,6 +49913,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (periderm) +AnnotationAssertion(Annotation( "ISBN:9780878932504") Annotation( "PMID:25133425") Annotation( "PMID:35582825") "The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm.") +AnnotationAssertion( "EHDAA2:0001846") +AnnotationAssertion( "EHDAA:6538") +AnnotationAssertion( "FMA:295662") +AnnotationAssertion( "NCIT:C34247") +AnnotationAssertion( "TAO:0001185") +AnnotationAssertion( "VHOG:0001680") +AnnotationAssertion( "XAO:0000029") +AnnotationAssertion( "ZFA:0001185") AnnotationAssertion(rdfs:label "periderm") SubClassOf( ) SubClassOf( ) @@ -33170,6 +49929,12 @@ SubClassOf( (pre-chordal neural plate) +AnnotationAssertion(Annotation( "XB:curator") "The portion of neural plate anterior to the mid-hindbrain junction.") +AnnotationAssertion( "AAO:0011084") +AnnotationAssertion( "TAO:0007016") +AnnotationAssertion( "VHOG:0001200") +AnnotationAssertion( "XAO:0000045") +AnnotationAssertion( "ZFA:0007016") AnnotationAssertion(rdfs:label "pre-chordal neural plate") SubClassOf( ) SubClassOf( ) @@ -33178,6 +49943,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (chordal neural plate) +AnnotationAssertion(Annotation( "XB:curator") "The portion of neural plate posterior to the mid-hindbrain junction.") +AnnotationAssertion( "TAO:0007017") +AnnotationAssertion( "VHOG:0001201") +AnnotationAssertion( "XAO:0000046") +AnnotationAssertion( "ZFA:0007017") AnnotationAssertion(rdfs:label "chordal neural plate") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33185,6 +49955,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presomitic mesoderm) +AnnotationAssertion(Annotation( "ZFIN:curator") "Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.") +AnnotationAssertion( "AAO:0011086") +AnnotationAssertion( "EFO:0001982") +AnnotationAssertion( "EMAPA:16189") +AnnotationAssertion( "EMAPA:16752") +AnnotationAssertion( "TAO:0000279") +AnnotationAssertion( "VHOG:0000559") +AnnotationAssertion( "XAO:0000057") +AnnotationAssertion( "ZFA:0000279") AnnotationAssertion(rdfs:label "presomitic mesoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33194,6 +49973,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (blood island) +AnnotationAssertion(Annotation( "Wikipedia:Blood_island_of_umbilical_vesicle") "Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted].") +AnnotationAssertion( "AAO:0011006") +AnnotationAssertion( "EFO:0003489") +AnnotationAssertion( "EHDAA:207") +AnnotationAssertion( "NCIT:C34113") +AnnotationAssertion( "TAO:0000094") +AnnotationAssertion( "TE:E5.11.2.0.0.0.4") +AnnotationAssertion( "VHOG:0000085") +AnnotationAssertion( "Wikipedia:Blood_island_of_umbilical_vesicle") +AnnotationAssertion( "XAO:0000067") +AnnotationAssertion( "ZFA:0000094") AnnotationAssertion(rdfs:label "blood island") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33201,6 +49991,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (prechordal plate) +AnnotationAssertion(Annotation( "ISBN:0838580343") Annotation( "MP:0004387") "A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue.") +AnnotationAssertion( "AAO:0011085") +AnnotationAssertion( "EHDAA2:0001493") +AnnotationAssertion( "EHDAA:181") +AnnotationAssertion( "FMA:295532") +AnnotationAssertion( "TAO:0000060") +AnnotationAssertion( "VHOG:0000086") +AnnotationAssertion( "Wikipedia:Prechordal_plate") +AnnotationAssertion( "XAO:0000079") +AnnotationAssertion( "ZFA:0000060") AnnotationAssertion(rdfs:label "prechordal plate") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33208,6 +50008,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (intermediate mesoderm) +AnnotationAssertion(Annotation( "GOC:curators") Annotation( "Wikipedia:Intermediate_mesoderm") "The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.") +AnnotationAssertion( "AAO:0010575") +AnnotationAssertion( "EMAPA:16056") +AnnotationAssertion( "EMAPA:16178") +AnnotationAssertion( "FMA:293147") +AnnotationAssertion( "NCIT:C34193") +AnnotationAssertion( "SCTID:361476001") +AnnotationAssertion( "TAO:0001206") +AnnotationAssertion( "VHOG:0000087") +AnnotationAssertion( "Wikipedia:Intermediate_mesoderm") +AnnotationAssertion( "XAO:0000085") +AnnotationAssertion( "ZFA:0001206") AnnotationAssertion(rdfs:label "intermediate mesoderm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33218,12 +50030,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dorsolateral placode) +AnnotationAssertion(Annotation( "ZFIN:curator") "Lateral neurogenic placodes positioned dorsal of the epibranchial placodes.") +AnnotationAssertion( "TAO:0001310") +AnnotationAssertion( "VHOG:0000103") +AnnotationAssertion( "XAO:0000187") +AnnotationAssertion( "ZFA:0001310") +AnnotationAssertion(rdfs:comment "The only remaining dorsolateral placode in land vertebrates is the otic/octaval placode") AnnotationAssertion(rdfs:label "dorsolateral placode") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (axial mesoderm) +AnnotationAssertion(Annotation( "GO:0048318") Annotation( "Wikipedia:Chordamesoderm") "The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.") +AnnotationAssertion( "AAO:0011017") +AnnotationAssertion( "EFO:0003647") +AnnotationAssertion( "TAO:0001204") +AnnotationAssertion( "VHOG:0000107") +AnnotationAssertion( "Wikipedia:Chordamesoderm") +AnnotationAssertion( "XAO:0000205") +AnnotationAssertion( "ZFA:0001204") AnnotationAssertion(rdfs:label "axial mesoderm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33232,12 +50058,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trigeminal placode complex) +AnnotationAssertion(Annotation( "PMID:22512454") Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/693") "A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion.") +AnnotationAssertion( "EFO:0003433") +AnnotationAssertion( "EHDAA2:0004209") +AnnotationAssertion( "TAO:0000162") +AnnotationAssertion( "VHOG:0000109") +AnnotationAssertion( "XAO:0000225") +AnnotationAssertion( "ZFA:0000162") AnnotationAssertion(rdfs:label "trigeminal placode complex") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (eye primordium) +AnnotationAssertion(Annotation( "GO:0046619") Annotation( "ZFA:0000570") "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles.") +AnnotationAssertion( "AAO:0011038") +AnnotationAssertion( "EFO:0003541") +AnnotationAssertion( "EHDAA2:0004431") +AnnotationAssertion( "TAO:0000570") +AnnotationAssertion( "XAO:0000227") +AnnotationAssertion( "XAO:0004090") +AnnotationAssertion( "ZFA:0000570") AnnotationAssertion(rdfs:label "eye primordium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33251,6 +50092,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (optic cup) +AnnotationAssertion(Annotation( "MP:0004269") Annotation( "Wikipedia:Optic_cup_(embryology)") Annotation( "ZFA:0001202") "Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP].") +AnnotationAssertion( "BTO:0005351") +AnnotationAssertion( "EHDAA2:0001303") +AnnotationAssertion( "EHDAA:2912") +AnnotationAssertion( "EMAPA:16674") +AnnotationAssertion( "NCIT:C34233") +AnnotationAssertion( "SCTID:308789007") +AnnotationAssertion( "TAO:0001202") +AnnotationAssertion( "VHOG:0000167") +AnnotationAssertion( "ZFA:0001202") AnnotationAssertion(rdfs:label "optic cup") SubClassOf( ) SubClassOf( ) @@ -33260,6 +50111,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lens placode) +AnnotationAssertion(Annotation( "Wikipedia:Lens_placode") Annotation( "ZFIN:curator") "A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP].") +AnnotationAssertion( "AAO:0011055") +AnnotationAssertion( "EFO:0003494") +AnnotationAssertion( "EHDAA2:0000982") +AnnotationAssertion( "EHDAA:2908") +AnnotationAssertion( "EMAPA:16672") +AnnotationAssertion( "FMA:296767") +AnnotationAssertion( "NCIT:C34202") +AnnotationAssertion( "TAO:0000122") +AnnotationAssertion( "VHOG:0000166") +AnnotationAssertion( "Wikipedia:Lens_placode") +AnnotationAssertion( "XAO:0000240") +AnnotationAssertion( "ZFA:0000122") AnnotationAssertion(rdfs:label "lens placode") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33272,6 +50136,23 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural plate) +AnnotationAssertion(Annotation( "ISBN:0815318960") Annotation( "OMD:neural+plate") Annotation( "Wikipedia:Neural_plate") Annotation( "ZFIN:curator") "A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].") +AnnotationAssertion( "AAO:0011072") +AnnotationAssertion( "BTO:0001765") +AnnotationAssertion( "DHBA:10153") +AnnotationAssertion( "DMBA:15565") +AnnotationAssertion( "EHDAA:346") +AnnotationAssertion( "EHDAA:902") +AnnotationAssertion( "EMAPA:35593") +AnnotationAssertion( "FMA:293879") +AnnotationAssertion( "NCIT:C34225") +AnnotationAssertion( "RETIRED_EHDAA2:0001252") +AnnotationAssertion( "TAO:0000132") +AnnotationAssertion( "VHOG:0000068") +AnnotationAssertion( "Wikipedia:Neural_plate") +AnnotationAssertion( "XAO:0000249") +AnnotationAssertion( "ZFA:0000132") +AnnotationAssertion( "neuronames:1362") AnnotationAssertion(rdfs:label "neural plate") SubClassOf( ) SubClassOf( ) @@ -33282,6 +50163,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (posterior neural tube) +AnnotationAssertion( "AAO:0011082") +AnnotationAssertion( "TAO:0007037") +AnnotationAssertion( "VHOG:0001383") +AnnotationAssertion( "XAO:0000250") +AnnotationAssertion( "ZFA:0007037") AnnotationAssertion(rdfs:label "posterior neural tube") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33289,6 +50175,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (paraxial mesoderm) +AnnotationAssertion(Annotation( "GO:0048339") Annotation( "https://github.com/obophenotype/uberon/issues/30") "The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].") +AnnotationAssertion( "AAO:0010568") +AnnotationAssertion( "EFO:0003515") +AnnotationAssertion( "EMAPA:16183") +AnnotationAssertion( "EMAPA:16751") +AnnotationAssertion( "FMA:293145") +AnnotationAssertion( "NCIT:C34244") +AnnotationAssertion( "SCTID:361475002") +AnnotationAssertion( "TAO:0000255") +AnnotationAssertion( "VHOG:0000114") +AnnotationAssertion( "Wikipedia:Paraxial_mesoderm") +AnnotationAssertion( "XAO:0000259") +AnnotationAssertion( "ZFA:0000255") AnnotationAssertion(rdfs:label "paraxial mesoderm") SubClassOf( ) SubClassOf( ) @@ -33299,6 +50198,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epibranchial placode) +AnnotationAssertion(Annotation( "VHOG:0000117") "Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia.") +AnnotationAssertion( "AAO:0011036") +AnnotationAssertion( "EFO:0003455") +AnnotationAssertion( "FMA:293968") +AnnotationAssertion( "TAO:0001294") +AnnotationAssertion( "VHOG:0000117") +AnnotationAssertion( "XAO:0000284") +AnnotationAssertion( "ZFA:0001294") AnnotationAssertion(rdfs:label "epibranchial placode") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33307,6 +50214,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anterior neural tube) +AnnotationAssertion( "AAO:0011012") +AnnotationAssertion( "TAO:0007038") +AnnotationAssertion( "VHOG:0001384") +AnnotationAssertion( "XAO:0000307") +AnnotationAssertion( "ZFA:0007038") AnnotationAssertion(rdfs:label "anterior neural tube") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33314,6 +50226,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lateral plate mesoderm) +AnnotationAssertion(Annotation( "MP:0010117") Annotation( "Wikipedia:Lateral_plate_mesoderm") "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP].") +AnnotationAssertion( "AAO:0010574") +AnnotationAssertion( "EHDAA2:0000919") +AnnotationAssertion( "EHDAA:379") +AnnotationAssertion( "EMAPA:16179") +AnnotationAssertion( "FMA:293149") +AnnotationAssertion( "NCIT:C34199") +AnnotationAssertion( "SCTID:361477005") +AnnotationAssertion( "TAO:0000121") +AnnotationAssertion( "VHOG:0000118") +AnnotationAssertion( "Wikipedia:Lateral_plate_mesoderm") +AnnotationAssertion( "XAO:0000311") +AnnotationAssertion( "ZFA:0000121") AnnotationAssertion(rdfs:label "lateral plate mesoderm") SubClassOf( ) SubClassOf( ) @@ -33325,6 +50250,24 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (myotome) +AnnotationAssertion(Annotation( "AEO:0001018") "A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells.") +AnnotationAssertion( "AAO:0011067") +AnnotationAssertion( "AEO:0001018") +AnnotationAssertion( "BTO:0000742") +AnnotationAssertion( "EHDAA2_RETIRED:0003431") +AnnotationAssertion( "EHDAA:1721") +AnnotationAssertion( "EHDAA:1727") +AnnotationAssertion( "EHDAA:1733") +AnnotationAssertion( "EHDAA:1739") +AnnotationAssertion( "EMAPA:32841") +AnnotationAssertion( "FMA:295658") +AnnotationAssertion( "NCIT:C34214") +AnnotationAssertion( "SCTID:344535001") +AnnotationAssertion( "TAO:0001056") +AnnotationAssertion( "VHOG:0001244") +AnnotationAssertion( "Wikipedia:Myotome") +AnnotationAssertion( "XAO:0000315") +AnnotationAssertion( "ZFA:0001056") AnnotationAssertion(rdfs:label "myotome") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33332,6 +50275,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trunk neural crest) +AnnotationAssertion(Annotation( "ISBN:0815318960") Annotation( "Wikipedia:Trunk_neural_crest") "Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia].") +AnnotationAssertion( "AAO:0010582") +AnnotationAssertion( "EFO:0003605") +AnnotationAssertion( "EHDAA2:0001901") +AnnotationAssertion( "TAO:0001024") +AnnotationAssertion( "VHOG:0000062") +AnnotationAssertion( "Wikipedia:Trunk_neural_crest") +AnnotationAssertion( "XAO:0000319") +AnnotationAssertion( "ZFA:0001024") AnnotationAssertion(rdfs:label "trunk neural crest") SubClassOf( ) SubClassOf( ) @@ -33341,6 +50293,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart primordium) +AnnotationAssertion(Annotation( "ZFIN:curator") "Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.") +AnnotationAssertion( "AAO:0011044") +AnnotationAssertion( "BTO:0001887") +AnnotationAssertion( "NCIT:C34276") +AnnotationAssertion( "TAO:0000028") +AnnotationAssertion( "XAO:0000336") +AnnotationAssertion( "ZFA:0000028") AnnotationAssertion(rdfs:label "heart primordium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33348,8 +50307,37 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (caudal artery) + +AnnotationAssertion(Annotation( "Wikipedia:Caudal_artery") Annotation( "ZFIN:curator") "Extension of the dorsal aorta in the tail.") +AnnotationAssertion( "AAO:0011023") +AnnotationAssertion( "EFO:0003472") +AnnotationAssertion( "TAO:0000011") +AnnotationAssertion( "VHOG:0000123") +AnnotationAssertion( "Wikipedia:Caudal_artery") +AnnotationAssertion( "XAO:0000364") +AnnotationAssertion( "ZFA:0000011") +AnnotationAssertion(rdfs:label "caudal artery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (sclerotome) +AnnotationAssertion(Annotation( "Wikipedia:Sclerotome") Annotation( "XB:curator") Annotation( "https://github.com/obophenotype/uberon/issues/316") "Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].") +AnnotationAssertion( "AAO:0010571") +AnnotationAssertion( "AEO:0000212") +AnnotationAssertion( "EHDAA2:0003439") +AnnotationAssertion( "EMAPA:31159") +AnnotationAssertion( "FMA:295652") +AnnotationAssertion( "NCIT:C34287") +AnnotationAssertion( "TAO:0001080") +AnnotationAssertion( "VHOG:0000680") +AnnotationAssertion( "Wikipedia:Sclerotome") +AnnotationAssertion( "XAO:0000397") +AnnotationAssertion( "ZFA:0001080") AnnotationAssertion(rdfs:label "sclerotome") SubClassOf( ) SubClassOf( ) @@ -33358,6 +50346,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranial neural crest) +AnnotationAssertion(Annotation( "MGI:anna") "Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage.") +AnnotationAssertion( "AAO:0010580") +AnnotationAssertion( "EFO:0003645") +AnnotationAssertion( "EHDAA2:0004420") +AnnotationAssertion( "EMAPA:16091") +AnnotationAssertion( "TAO:0001194") +AnnotationAssertion( "VHOG:0000063") +AnnotationAssertion( "Wikipedia:Cranial_neural_crest") +AnnotationAssertion( "XAO:0001001") +AnnotationAssertion( "ZFA:0001194") AnnotationAssertion(rdfs:label "cranial neural crest") SubClassOf( ) SubClassOf( ) @@ -33367,22 +50365,69 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (female organism) +AnnotationAssertion(Annotation( "CARO:0000028") "Gonochoristic organism that can produce female gametes.") +AnnotationAssertion( "AAO:0010030") +AnnotationAssertion( "BILA:0000028") +AnnotationAssertion( "CARO:0000028") +AnnotationAssertion( "FMA:67812") +AnnotationAssertion( "HAO:0000028") +AnnotationAssertion( "SCTID:362608006") +AnnotationAssertion( "TAO:0000303") +AnnotationAssertion( "TGMA:0001839") +AnnotationAssertion( "XAO:0003005") +AnnotationAssertion( "ZFA:0000303") AnnotationAssertion(rdfs:label "female organism") SubClassOf( ) # Class: (surface structure) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/24") "Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism.") +AnnotationAssertion( "AAO:0010337") +AnnotationAssertion( "AEO_RETIRED:0000010") +AnnotationAssertion( "EHDAA2_RETIRED:0003010") +AnnotationAssertion( "TAO:0000292") +AnnotationAssertion( "VSAO:0000001") +AnnotationAssertion( "Wikipedia:Surface_structure") +AnnotationAssertion( "XAO:0003028") +AnnotationAssertion( "ZFA:0000292") +AnnotationAssertion( "galen:SurfaceRegion") AnnotationAssertion(rdfs:label "surface structure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (compound organ) +AnnotationAssertion(Annotation( "CARO:0000024") "Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types.") +AnnotationAssertion( "AAO:0010015") +AnnotationAssertion( "AEO:0000024") +AnnotationAssertion( "BILA:0000024") +AnnotationAssertion( "CARO:0000024") +AnnotationAssertion( "EHDAA2:0003024") +AnnotationAssertion( "HAO:0000024") +AnnotationAssertion( "TADS:0000598") +AnnotationAssertion( "TAO:0000496") +AnnotationAssertion( "TGMA:0001837") +AnnotationAssertion( "VHOG:0001723") +AnnotationAssertion( "XAO:0003041") +AnnotationAssertion( "ZFA:0000496") AnnotationAssertion(rdfs:label "compound organ") SubClassOf( ) # Class: (mesenchyme) +AnnotationAssertion(Annotation( "https://archive.org/details/invertebratesnde00brus/page/n240/mode/2up") Annotation( "https://en.wikipedia.org/wiki/Mesenchyme") Annotation( "https://github.com/obophenotype/uberon/issues/1641") "Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme.") +AnnotationAssertion( "AAO:0010427") +AnnotationAssertion( "AEO:0000145") +AnnotationAssertion( "BTO:0001393") +AnnotationAssertion( "CALOHA:TS-0620") +AnnotationAssertion( "EHDAA2:0003145") +AnnotationAssertion( "EV:0100007") +AnnotationAssertion( "NCIT:C13301") +AnnotationAssertion( "TAO:0000393") +AnnotationAssertion( "VHOG:0000170") +AnnotationAssertion( "Wikipedia:Mesenchyme") +AnnotationAssertion( "XAO:0003046") +AnnotationAssertion( "ZFA:0000393") AnnotationAssertion(rdfs:label "mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33390,8 +50435,29 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (olfactory region) + +AnnotationAssertion(Annotation( "TAO:0000351") "Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ.") +AnnotationAssertion( "AAO:0010206") +AnnotationAssertion( "EFO:0003525") +AnnotationAssertion( "NCIT:C98765") +AnnotationAssertion( "TAO:0000351") +AnnotationAssertion( "XAO:0003172") +AnnotationAssertion( "ZFA:0000351") +AnnotationAssertion(rdfs:label "olfactory region") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (dermatocranium) +AnnotationAssertion(Annotation( "Wikipedia:Skull_roof") Annotation( "ZFA:0000863") "Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified].") +AnnotationAssertion( "AAO:0010154") +AnnotationAssertion( "TAO:0000863") +AnnotationAssertion( "VHOG:0001665") +AnnotationAssertion( "Wikipedia:Skull_roof") +AnnotationAssertion( "XAO:0003169") +AnnotationAssertion( "ZFA:0000863") AnnotationAssertion(rdfs:label "dermatocranium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33399,16 +50465,47 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch 4) +AnnotationAssertion(Annotation( "MP:0006340") "Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus.") +AnnotationAssertion( "AAO:0010366") +AnnotationAssertion( "EHDAA2:0000086") +AnnotationAssertion( "EHDAA:1663") +AnnotationAssertion( "EMAPA:16760") +AnnotationAssertion( "FMA:293035") +AnnotationAssertion( "SCTID:308770007") +AnnotationAssertion( "TAO:0001599") +AnnotationAssertion( "VHOG:0000299") +AnnotationAssertion( "XAO:0000449") +AnnotationAssertion( "ZFA:0001607") AnnotationAssertion(rdfs:label "pharyngeal arch 4") SubClassOf( ) # Class: (pharyngeal arch 6) +AnnotationAssertion(Annotation( "MP:0006347") "The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles.") +AnnotationAssertion( "AAO:0010368") +AnnotationAssertion( "EHDAA2:0004075") +AnnotationAssertion( "EMAPA:32766") +AnnotationAssertion( "FMA:293047") +AnnotationAssertion( "SCTID:308772004") +AnnotationAssertion( "TAO:0001601") +AnnotationAssertion( "VHOG:0001205") +AnnotationAssertion( "XAO:0000453") +AnnotationAssertion( "ZFA:0001609") AnnotationAssertion(rdfs:label "pharyngeal arch 6") SubClassOf( ) # Class: (pharyngeal arch artery 1) +AnnotationAssertion(Annotation( "MP:0010355") "The vessels formed within the first pair of branchial arches in embryogenesis.") +AnnotationAssertion( "AAO:0010415") +AnnotationAssertion( "EHDAA2:0000007") +AnnotationAssertion( "EMAPA:16202") +AnnotationAssertion( "EMAPA:16685") +AnnotationAssertion( "SCTID:308774003") +AnnotationAssertion( "TAO:0005005") +AnnotationAssertion( "VHOG:0000149") +AnnotationAssertion( "XAO:0000342") +AnnotationAssertion( "ZFA:0005005") AnnotationAssertion(rdfs:label "pharyngeal arch artery 1") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33417,6 +50514,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch artery 4) +AnnotationAssertion(Annotation( "MP:0006354") "The vessels formed within the fourth pair of branchial arches in embryogenesis.") +AnnotationAssertion( "AAO:0010420") +AnnotationAssertion( "EHDAA2:0000087") +AnnotationAssertion( "EMAPA:17004") +AnnotationAssertion( "SCTID:308777005") +AnnotationAssertion( "TAO:0005008") +AnnotationAssertion( "Wikipedia:Aortic_arches#Arch_4") +AnnotationAssertion( "XAO:0000355") +AnnotationAssertion( "ZFA:0005008") +AnnotationAssertion(rdfs:comment "proximal right subclavian") AnnotationAssertion(rdfs:label "pharyngeal arch artery 4") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33424,6 +50531,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch artery 6) +AnnotationAssertion(Annotation( "MP:0006355") "The vessels formed within the sixth pair of branchial arches in embryogenesis.") +AnnotationAssertion( "AAO:0010422") +AnnotationAssertion( "EHDAA2:0000102") +AnnotationAssertion( "EMAPA:17005") +AnnotationAssertion( "SCTID:308779008") +AnnotationAssertion( "TAO:0005016") +AnnotationAssertion( "VHOG:0000144") +AnnotationAssertion( "Wikipedia:Aortic_arches#Arch_6") +AnnotationAssertion( "XAO:0000353") +AnnotationAssertion( "ZFA:0005016") AnnotationAssertion(rdfs:label "pharyngeal arch artery 6") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33431,7 +50548,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trachea) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0060438") Annotation( "Wikipedia:Vertebrate_trachea") "The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph].") +AnnotationAssertion( "AAO:0010140") +AnnotationAssertion( "BTO:0001388") +AnnotationAssertion( "CALOHA:TS-1060") +AnnotationAssertion( "EFO:0000935") +AnnotationAssertion( "EHDAA2:0002066") +AnnotationAssertion( "EHDAA:3078") +AnnotationAssertion( "EMAPA:16853") +AnnotationAssertion( "EV:0100040") +AnnotationAssertion( "FMA:7394") +AnnotationAssertion( "GAID:361") +AnnotationAssertion( "MA:0000441") +AnnotationAssertion( "MAT:0000137") +AnnotationAssertion( "MESH:D014132") +AnnotationAssertion( "MIAA:0000137") +AnnotationAssertion( "NCIT:C12428") +AnnotationAssertion( "SCTID:181213009") +AnnotationAssertion( "VHOG:0000371") +AnnotationAssertion( "Wikipedia:Vertebrate_trachea") +AnnotationAssertion( "XAO:0000118") AnnotationAssertion(rdfs:label "trachea") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -33442,12 +50578,35 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Cranium_(anatomy)") Annotation( "http://orcid.org/0000-0002-6601-2165") "Upper portion of the skull that excludes the mandible (when present in the organism).") +AnnotationAssertion( "BTO:0001328") +AnnotationAssertion( "EFO:0000831") +AnnotationAssertion( "EHDAA:6029") +AnnotationAssertion( "FMA:71325") +AnnotationAssertion( "MA:0000316") +AnnotationAssertion( "MAT:0000340") +AnnotationAssertion( "MIAA:0000340") +AnnotationAssertion( "SCTID:181889008") +AnnotationAssertion( "VHOG:0000334") +AnnotationAssertion( "Wikipedia:Cranium_(anatomy)") AnnotationAssertion(rdfs:label "cranium") SubClassOf( ) # Class: (skull) +AnnotationAssertion(Annotation( "PMID:11523816") Annotation( "Wikipedia:Skull") Annotation( "http://sourceforge.net/tracker/?func=detail&aid=2962656&group_id=76834&atid=1205376") "Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP].") +AnnotationAssertion( "BTO:0001295") +AnnotationAssertion( "CALOHA:TS-2344") +AnnotationAssertion( "EHDAA2:0000325") +AnnotationAssertion( "EMAPA:17680") +AnnotationAssertion( "FMA:46565") +AnnotationAssertion( "GAID:82") +AnnotationAssertion( "MESH:D012886") +AnnotationAssertion( "NCIT:C12789") +AnnotationAssertion( "SCTID:110530005") +AnnotationAssertion( "Wikipedia:Skull") +AnnotationAssertion( "WikipediaCategory:Skull") +AnnotationAssertion( "galen:Skull") AnnotationAssertion(rdfs:label "skull") SubClassOf( ) SubClassOf( ) @@ -33459,6 +50618,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (reproductive organ) +AnnotationAssertion(Annotation( "UBERON:xp") "An organ involved in reproduction.") +AnnotationAssertion( "MA:0001752") +AnnotationAssertion( "MESH:D005835") +AnnotationAssertion( "NCIT:C25177") +AnnotationAssertion( "SCTID:128181006") +AnnotationAssertion( "TGMA:0000591") +AnnotationAssertion( "WBbt:0008422") AnnotationAssertion(rdfs:label "reproductive organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33467,6 +50633,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (female reproductive organ) +AnnotationAssertion(Annotation( "UBERON:xp") "A female organ involved in reproduction.") +AnnotationAssertion( "EMAPA:28540") +AnnotationAssertion( "MA:0000544") AnnotationAssertion(rdfs:label "female reproductive organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33474,18 +50643,40 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (alveolus) +AnnotationAssertion(Annotation( "Wikipedia:Alveolus") "Organ part that has the form of a hollow cavity[WP].") +AnnotationAssertion( "EFO:0002513") +AnnotationAssertion( "FMA:82493") +AnnotationAssertion( "NCIT:C12986") +AnnotationAssertion( "Wikipedia:Alveolus") AnnotationAssertion(rdfs:label "alveolus") SubClassOf( ) # Class: (ovary septum) +AnnotationAssertion(Annotation( "GO:0080126") "Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO].") AnnotationAssertion(rdfs:label "ovary septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelium of upper jaw) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a upper jaw [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0002119") +AnnotationAssertion( "EHDAA:8027") +AnnotationAssertion( "EMAPA:18971") +AnnotationAssertion(rdfs:label "epithelium of upper jaw") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (epithelium of lower jaw) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a lower jaw [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0001019") +AnnotationAssertion( "EHDAA:7999") +AnnotationAssertion( "EMAPA:35516") +AnnotationAssertion( "VHOG:0000802") AnnotationAssertion(rdfs:label "epithelium of lower jaw") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33493,6 +50684,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (yolk sac endoderm) +AnnotationAssertion(Annotation( "UBERON:cjm") "The portion of the yolk sac that is derived from endoderm and lines the yolk sac.") +AnnotationAssertion( "EHDAA2:0002215") +AnnotationAssertion( "EHDAA:166") +AnnotationAssertion( "EMAPA:16086") +AnnotationAssertion( "VHOG:0000626") AnnotationAssertion(rdfs:label "yolk sac endoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33502,22 +50698,83 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endoderm of foregut) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endoderm that is part of a foregut [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0004568") +AnnotationAssertion( "EHDAA:524") AnnotationAssertion(rdfs:label "endoderm of foregut") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ) +# Class: (endoderm of midgut) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An endoderm that is part of a midgut [Automatically generated definition].") +AnnotationAssertion( "EHDAA:987") +AnnotationAssertion( "EMAPA:16257") +AnnotationAssertion( "RETIRED_EHDAA2:0001194") +AnnotationAssertion( "VHOG:0001080") +AnnotationAssertion(rdfs:label "endoderm of midgut") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (endoderm of hindgut) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An endoderm that is part of a hindgut [Automatically generated definition].") +AnnotationAssertion( "EHDAA:979") +AnnotationAssertion( "RETIRED_EHDAA2:0000781") +AnnotationAssertion(rdfs:label "endoderm of hindgut") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + # Class: (skeletal muscle tissue of eye) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0000486") +AnnotationAssertion( "EHDAA:2923") +AnnotationAssertion( "EMAPA:17844") AnnotationAssertion(rdfs:label "skeletal muscle tissue of eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (skeleton of upper jaw) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones.") +AnnotationAssertion( "AAO:0000622") +AnnotationAssertion( "EHDAA2:0002128") +AnnotationAssertion( "EHDAA:8041") +AnnotationAssertion( "EMAPA:17927") +AnnotationAssertion( "FMA:54397") +AnnotationAssertion( "MA:0001908") +AnnotationAssertion( "VHOG:0000429") +AnnotationAssertion( "XAO:0003087") +AnnotationAssertion(rdfs:label "skeleton of upper jaw") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (skeleton of lower jaw) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage.") +AnnotationAssertion( "AAO:0000274") +AnnotationAssertion( "EHDAA2:0004606") +AnnotationAssertion( "EHDAA:8005") +AnnotationAssertion( "EMAPA:17910") +AnnotationAssertion( "FMA:54398") +AnnotationAssertion( "MA:0001906") +AnnotationAssertion( "TAO:0001273") +AnnotationAssertion( "VHOG:0000428") +AnnotationAssertion( "XAO:0003084") +AnnotationAssertion( "ZFA:0001273") AnnotationAssertion(rdfs:label "skeleton of lower jaw") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33529,14 +50786,76 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endothelium of trachea) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of a trachea.") +AnnotationAssertion( "EHDAA:3082") +AnnotationAssertion( "RETIRED_EHDAA2:0002068") AnnotationAssertion(rdfs:label "endothelium of trachea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ) +# Class: (mesentery of stomach) + +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/mesogastrium") "The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum.") +AnnotationAssertion( "EHDAA2:0001922") +AnnotationAssertion( "EHDAA:2999") +AnnotationAssertion( "EMAPA:17024") +AnnotationAssertion( "MA:0001617") +AnnotationAssertion( "SCTID:261623000") +AnnotationAssertion( "VHOG:0000358") +AnnotationAssertion(rdfs:label "mesentery of stomach") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mesentery of heart) + +AnnotationAssertion(Annotation( "MA:th") "A mesentery that surrounds the heart.") +AnnotationAssertion( "EHDAA:432") +AnnotationAssertion( "EMAPA:16212") +AnnotationAssertion( "RETIRED_EHDAA2:0000739") +AnnotationAssertion( "VHOG:0000353") +AnnotationAssertion(rdfs:label "mesentery of heart") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mesentery of oesophagus) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesentery that is part of a esophagus [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0001288") +AnnotationAssertion( "EHDAA:2943") +AnnotationAssertion( "EMAPA:16836") +AnnotationAssertion( "MA:0001569") +AnnotationAssertion( "VHOG:0000415") +AnnotationAssertion(rdfs:label "mesentery of oesophagus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (mesentery of midgut) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesentery that is part of a midgut [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0001202") +AnnotationAssertion( "EHDAA:3031") +AnnotationAssertion( "EMAPA:16721") +AnnotationAssertion( "EMAPA:17039") +AnnotationAssertion( "EMAPA:17197") +AnnotationAssertion( "VHOG:0000413") +AnnotationAssertion(rdfs:label "mesentery of midgut") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (gland of foregut) +AnnotationAssertion(Annotation( "OBOL:automatic") "A gland that is part of a foregut [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0000567") +AnnotationAssertion( "EHDAA:950") +AnnotationAssertion( "EMAPA:16557") +AnnotationAssertion( "VHOG:0000650") AnnotationAssertion(rdfs:label "gland of foregut") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33544,6 +50863,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal gland) +AnnotationAssertion(Annotation( "http://www.biology-online.org/dictionary/") "Racemose mucous glands beneath the mucous membrane of the pharynx.") +AnnotationAssertion( "BTO:0004849") +AnnotationAssertion( "EHDAA2:0001461") +AnnotationAssertion( "EHDAA:2967") +AnnotationAssertion( "FMA:55075") AnnotationAssertion(rdfs:label "pharyngeal gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33552,6 +50876,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gland of integumental system) +AnnotationAssertion(Annotation( "OBOL:automatic") "A gland that is part of a integumental system [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0000837") +AnnotationAssertion( "EMAPA:17758") +AnnotationAssertion( "MA:0000144") +AnnotationAssertion( "VHOG:0000654") AnnotationAssertion(rdfs:label "gland of integumental system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33559,6 +50888,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesoderm blood island) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood island that is part of a mesoderm.") +AnnotationAssertion( "EHDAA2:0003241") +AnnotationAssertion( "EHDAA:170") AnnotationAssertion(rdfs:label "mesoderm blood island") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33570,6 +50902,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (eye mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing camera-type eye.") +AnnotationAssertion( "EHDAA2:0000485") +AnnotationAssertion( "EHDAA:2910") +AnnotationAssertion( "EMAPA:16673") +AnnotationAssertion( "VHOG:0001084") AnnotationAssertion(rdfs:label "eye mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33579,7 +50916,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesenchyme of ovary) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing ovary [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0001362") +AnnotationAssertion( "EHDAA:8128") +AnnotationAssertion( "VHOG:0001441") AnnotationAssertion(rdfs:label "mesenchyme of ovary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33587,21 +50927,139 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesenchyme of yolk sac) +AnnotationAssertion(Annotation( "UBERON:cjm") "The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme.") +AnnotationAssertion( "EHDAA2:0002216") +AnnotationAssertion( "EHDAA:168") +AnnotationAssertion( "EHDAA:205") +AnnotationAssertion( "EMAPA:16087") +AnnotationAssertion( "EMAPA:16267") +AnnotationAssertion( "VHOG:0000503") +AnnotationAssertion( "VHOG:0000617") AnnotationAssertion(rdfs:label "mesenchyme of yolk sac") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mesenchyme of upper jaw) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing upper jaw [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0002124") +AnnotationAssertion( "EHDAA:8031") +AnnotationAssertion( "EMAPA:17929") +AnnotationAssertion( "VHOG:0001099") +AnnotationAssertion(rdfs:label "mesenchyme of upper jaw") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mesenchyme of lower jaw) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing lower jaw [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0001024") +AnnotationAssertion( "EHDAA:8003") +AnnotationAssertion( "EMAPA:17916") +AnnotationAssertion( "VHOG:0001069") AnnotationAssertion(rdfs:label "mesenchyme of lower jaw") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (submucosa of anal canal) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of an anal canal [Automatically generated definition].") +AnnotationAssertion( "EMAPA:27217") +AnnotationAssertion( "EMAPA:27227") +AnnotationAssertion( "EMAPA:27535") +AnnotationAssertion( "FMA:85399") +AnnotationAssertion( "SCTID:7892006") +AnnotationAssertion(rdfs:label "submucosa of anal canal") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of rectum) + +AnnotationAssertion(Annotation( "BTO:0002114") "The submucous layer of the wall of the rectum.") +AnnotationAssertion( "BTO:0002114") +AnnotationAssertion( "EMAPA:27083") +AnnotationAssertion( "FMA:15034") +AnnotationAssertion( "SCTID:71683001") +AnnotationAssertion(rdfs:label "submucosa of rectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of colon) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a colon [Automatically generated definition].") +AnnotationAssertion( "EMAPA:27379") +AnnotationAssertion( "FMA:14985") +AnnotationAssertion( "MA:0003200") +AnnotationAssertion( "SCTID:61647009") +AnnotationAssertion(rdfs:label "submucosa of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of duodenum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a duodenum [Automatically generated definition].") +AnnotationAssertion( "EMAPA:27027") +AnnotationAssertion( "EMAPA:27097") +AnnotationAssertion( "EMAPA:27239") +AnnotationAssertion( "FMA:14943") +AnnotationAssertion( "MA:0003213") +AnnotationAssertion( "SCTID:76519004") +AnnotationAssertion(rdfs:label "submucosa of duodenum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (serosa of rectum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A serous membrane that is part of a rectum [Automatically generated definition].") +AnnotationAssertion( "EMAPA:27087") +AnnotationAssertion( "FMA:15039") +AnnotationAssertion(rdfs:label "serosa of rectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (serosa of colon) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A serous membrane that is part of a colon [Automatically generated definition].") +AnnotationAssertion( "EMAPA:27387") +AnnotationAssertion( "FMA:14990") +AnnotationAssertion( "MA:0003199") +AnnotationAssertion( "SCTID:90132000") +AnnotationAssertion(rdfs:label "serosa of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (serosa of duodenum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A serous membrane that is part of a duodenum [Automatically generated definition].") +AnnotationAssertion( "EMAPA:27247") +AnnotationAssertion( "FMA:14948") +AnnotationAssertion( "MA:0003212") +AnnotationAssertion( "SCTID:1236009") +AnnotationAssertion(rdfs:label "serosa of duodenum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (ganglion of peripheral nervous system) +AnnotationAssertion(Annotation( "BIRNLEX:2548") "A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO).") +AnnotationAssertion( "BIRNLEX:2548") +AnnotationAssertion( "BTO:0001123") +AnnotationAssertion( "EMAPA:32814") +AnnotationAssertion( "MA:0001161") AnnotationAssertion(rdfs:label "ganglion of peripheral nervous system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33609,21 +51067,56 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ganglion of central nervous system) +AnnotationAssertion(Annotation( "OBOL:automatic") "A ganglion that is part of a central nervous system [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0000227") +AnnotationAssertion( "EMAPA:16658") +AnnotationAssertion( "FMA:83843") AnnotationAssertion(rdfs:label "ganglion of central nervous system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mucosa of anal canal) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of an anal canal [Automatically generated definition].") +AnnotationAssertion( "EMAPA:27531") +AnnotationAssertion( "FMA:74654") +AnnotationAssertion( "NCIT:C60784") +AnnotationAssertion( "SCTID:362170004") +AnnotationAssertion(rdfs:label "mucosa of anal canal") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mucosa of oral region) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a oral opening [Automatically generated definition].") +AnnotationAssertion( "SCTID:362083000") AnnotationAssertion(rdfs:label "mucosa of oral region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mucosa of rectum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a rectum [Automatically generated definition].") +AnnotationAssertion( "CALOHA:TS-2107") +AnnotationAssertion( "EMAPA:27081") +AnnotationAssertion( "FMA:15033") +AnnotationAssertion( "MA:0003218") +AnnotationAssertion( "SCTID:362167003") +AnnotationAssertion(rdfs:label "mucosa of rectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (epithelium of mucosa) +AnnotationAssertion(Annotation( "BTO:0003752") "A layer of epithelial cells on the surface of the mucosa.") +AnnotationAssertion( "BTO:0003752") +AnnotationAssertion(rdfs:comment "lies on top of lamina propria") AnnotationAssertion(rdfs:label "epithelium of mucosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33631,6 +51124,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a pharynx [Automatically generated definition].") +AnnotationAssertion( "BSA:0000112") +AnnotationAssertion( "BTO:0005240") +AnnotationAssertion( "EMAPA:16708") +AnnotationAssertion( "MA:0002725") +AnnotationAssertion( "RETIRED_EHDAA2:0001460") +AnnotationAssertion( "TAO:0001174") +AnnotationAssertion( "XAO:0003202") +AnnotationAssertion( "ZFA:0001174") AnnotationAssertion(rdfs:label "pharyngeal epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33639,8 +51141,49 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelium of midgut) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a midgut.") +AnnotationAssertion( "BTO:0005053") +AnnotationAssertion( "EHDAA2:0001195") +AnnotationAssertion( "EMAPA:16569") +AnnotationAssertion( "MA:0003205") +AnnotationAssertion(rdfs:label "epithelium of midgut") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (epithelium of hindgut) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a hindgut [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0000782") +AnnotationAssertion( "EMAPA:16717") +AnnotationAssertion( "MA:0003206") +AnnotationAssertion(rdfs:label "epithelium of hindgut") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (epithelium of rectum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a rectum [Automatically generated definition].") +AnnotationAssertion( "CALOHA:TS-2066") +AnnotationAssertion( "EHDAA2:0001594") +AnnotationAssertion( "EMAPA:17898") +AnnotationAssertion( "FMA:17510") +AnnotationAssertion( "MA:0003219") +AnnotationAssertion( "VHOG:0001037") +AnnotationAssertion(rdfs:label "epithelium of rectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (epithelium of right lung) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a right lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:17663") +AnnotationAssertion( "MA:0003132") AnnotationAssertion(rdfs:label "epithelium of right lung") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33648,6 +51191,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelium of left lung) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a left lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:17655") +AnnotationAssertion( "MA:0003131") AnnotationAssertion(rdfs:label "epithelium of left lung") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33655,6 +51201,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage bud ectoderm) +AnnotationAssertion(Annotation( "OBOL:automatic") "An unilaminar epithelium that surrounds a pectoral appendage bud.") +AnnotationAssertion( "EHDAA2:0002134") +AnnotationAssertion( "EMAPA:16407") +AnnotationAssertion( "VHOG:0001047") AnnotationAssertion(rdfs:label "pectoral appendage bud ectoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33667,7 +51217,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac muscle of right atrium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0004155") +AnnotationAssertion( "EMAPA:17326") +AnnotationAssertion( "FMA:7282") +AnnotationAssertion( "SCTID:362018002") +AnnotationAssertion( "VHOG:0001227") AnnotationAssertion(rdfs:label "cardiac muscle of right atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33675,6 +51230,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac muscle of left atrium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0004154") +AnnotationAssertion( "EMAPA:17320") +AnnotationAssertion( "FMA:7285") +AnnotationAssertion( "SCTID:189936008") +AnnotationAssertion( "VHOG:0001225") AnnotationAssertion(rdfs:label "cardiac muscle of left atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33682,6 +51243,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac muscle of right ventricle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition].") +AnnotationAssertion( "EMAPA:17342") +AnnotationAssertion( "FMA:83452") +AnnotationAssertion( "VHOG:0001236") AnnotationAssertion(rdfs:label "cardiac muscle of right ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33689,6 +51254,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac muscle of left ventricle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition].") +AnnotationAssertion( "EMAPA:17339") +AnnotationAssertion( "FMA:83453") +AnnotationAssertion( "VHOG:0001234") AnnotationAssertion(rdfs:label "cardiac muscle of left ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33696,7 +51265,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac muscle tissue of interventricular septum) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0004158") +AnnotationAssertion( "EMAPA:17335") +AnnotationAssertion( "FMA:84084") +AnnotationAssertion( "VHOG:0000999") AnnotationAssertion(rdfs:label "cardiac muscle tissue of interventricular septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33704,6 +51277,8 @@ SubClassOf( (skeletal muscle tissue of pharynx) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition].") +AnnotationAssertion( "EMAPA:18963") AnnotationAssertion(rdfs:label "skeletal muscle tissue of pharynx") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33711,6 +51286,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (smooth muscle of eye) +AnnotationAssertion(Annotation( "MGI:cwg") Annotation( "MP:0005247") "Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi.") +AnnotationAssertion( "EMAPA:18807") +AnnotationAssertion( "MA:0001268") AnnotationAssertion(rdfs:label "smooth muscle of eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33720,7 +51298,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (smooth muscle of trachea) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition].") +AnnotationAssertion( "BTO:0001391") +AnnotationAssertion( "EMAPA:19192") +AnnotationAssertion( "FMA:262010") +AnnotationAssertion( "MA:0001863") +AnnotationAssertion( "NCIT:C49306") AnnotationAssertion(rdfs:label "smooth muscle of trachea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33729,6 +51312,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesothelium of pericardial cavity) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesothelium that is part of a pericardium [Automatically generated definition].") +AnnotationAssertion( "RETIRED_EHDAA2:0001436") AnnotationAssertion(rdfs:label "mesothelium of pericardial cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33736,6 +51321,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesothelium of diaphragm) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesothelium that is part of a diaphragm [Automatically generated definition].") +AnnotationAssertion( "EMAPA:18429") AnnotationAssertion(rdfs:label "mesothelium of diaphragm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33744,13 +51331,70 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesothelium of pleural cavity) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesothelium that is part of a pleural cavity [Automatically generated definition].") +AnnotationAssertion( "BTO:0003155") +AnnotationAssertion( "EHDAA2:0001476") +AnnotationAssertion( "EMAPA:16775") +AnnotationAssertion( "FMA:18148") AnnotationAssertion(rdfs:label "mesothelium of pleural cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mesentery of urinary system) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesentery that is part of a urinary system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:17367") +AnnotationAssertion( "MA:0003233") +AnnotationAssertion(rdfs:label "mesentery of urinary system") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mesentery of hindgut) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesentery that is part of a hindgut [Automatically generated definition].") +AnnotationAssertion( "EMAPA:16718") +AnnotationAssertion(rdfs:label "mesentery of hindgut") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mesentery of rectum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesentery that is part of a rectum [Automatically generated definition].") +AnnotationAssertion( "EMAPA:18664") +AnnotationAssertion(rdfs:label "mesentery of rectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (mesentery of colon) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesentery that is part of a colon [Automatically generated definition].") +AnnotationAssertion( "EMAPA:18942") +AnnotationAssertion( "FMA:14645") +AnnotationAssertion( "SCTID:245457004") +AnnotationAssertion(rdfs:label "mesentery of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (mesentery of duodenum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesentery that is part of a duodenum [Automatically generated definition].") +AnnotationAssertion( "EMAPA:19081") +AnnotationAssertion(rdfs:label "mesentery of duodenum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (cartilage of respiratory system) +AnnotationAssertion(Annotation( "OBOL:automatic") "A cartilage element that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:18694") +AnnotationAssertion( "MA:0001818") AnnotationAssertion(rdfs:label "cartilage of respiratory system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33758,6 +51402,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gland of digestive tract) +AnnotationAssertion(Annotation( "OBOL:automatic") "A gland that is part of a digestive tract [Automatically generated definition].") +AnnotationAssertion( "EMAPA:18815") +AnnotationAssertion( "MA:0003202") AnnotationAssertion(rdfs:label "gland of digestive tract") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33766,6 +51413,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage bud mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a pectoral appendage bud.") +AnnotationAssertion( "EHDAA2:0002135") +AnnotationAssertion( "EHDAA:1703") +AnnotationAssertion( "EMAPA:16408") +AnnotationAssertion( "TAO:0000789") +AnnotationAssertion( "ZFA:0000789") AnnotationAssertion(rdfs:label "pectoral appendage bud mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33774,6 +51427,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dermis adipose tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "An adipose tissue that is part of a dermis [Automatically generated definition].") +AnnotationAssertion( "MA:0000798") AnnotationAssertion(rdfs:label "dermis adipose tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33781,6 +51436,8 @@ SubClassOf( (abdomen nerve) +AnnotationAssertion(Annotation( "OBOL:automatic") "A nerve that is part of an abdomen [Automatically generated definition].") +AnnotationAssertion( "MA:0000521") AnnotationAssertion(rdfs:label "abdomen nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33788,6 +51445,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neck nerve) +AnnotationAssertion(Annotation( "OBOL:automatic") "A nerve that is part of a neck [Automatically generated definition].") +AnnotationAssertion( "MA:0000588") AnnotationAssertion(rdfs:label "neck nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33795,6 +51454,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (iris nerve) +AnnotationAssertion(Annotation( "UBERON:cjm") "Any nerve that innervates the iris.") +AnnotationAssertion( "EMAPA:35449") +AnnotationAssertion( "MA:0001291") AnnotationAssertion(rdfs:label "iris nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33802,6 +51464,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nerve of trunk region) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk).") +AnnotationAssertion( "MA:0000515") AnnotationAssertion(rdfs:label "nerve of trunk region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33809,13 +51473,31 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic cavity nerve) +AnnotationAssertion(Annotation( "OBOL:automatic") "A nerve that is located in a thoracic cavity [Automatically generated definition].") +AnnotationAssertion( "MA:0000556") AnnotationAssertion(rdfs:label "thoracic cavity nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (trabecula carnea cardiac muscle tissue) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36573") +AnnotationAssertion( "FMA:84428") +AnnotationAssertion( "MA:0002833") +AnnotationAssertion(rdfs:label "trabecula carnea cardiac muscle tissue") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (head bone) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of a head [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35996") +AnnotationAssertion( "MA:0000576") +AnnotationAssertion( "SCTID:118646007") +AnnotationAssertion(rdfs:comment "Different sources vary regarding which bones are craniofacial; e.g. hyoid bone") AnnotationAssertion(rdfs:label "head bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33823,6 +51505,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neck bone) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of a neck [Automatically generated definition].") +AnnotationAssertion( "MA:0000584") AnnotationAssertion(rdfs:label "neck bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33830,6 +51514,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (facial bone) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of a facial skeleton [Automatically generated definition].") +AnnotationAssertion( "EMAPA:19019") +AnnotationAssertion( "EMAPA:35924") +AnnotationAssertion( "MA:0001482") +AnnotationAssertion( "MA:0003159") +AnnotationAssertion( "NCIT:C63706") +AnnotationAssertion( "SCTID:181799005") AnnotationAssertion(rdfs:label "facial bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33838,6 +51529,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trunk bone) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of a trunk [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36583") +AnnotationAssertion( "MA:0000512") +AnnotationAssertion( "SCTID:427358002") AnnotationAssertion(rdfs:label "trunk bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33845,14 +51540,34 @@ SubClassOf( (respiratory system artery) +AnnotationAssertion(Annotation( "OBOL:automatic") "An artery that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001804") AnnotationAssertion(rdfs:label "respiratory system artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (artery of upper lip) + +AnnotationAssertion(Annotation( "Wikipedia:Superior_labial_artery") "The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose.") +AnnotationAssertion( "FMA:49570") +AnnotationAssertion( "MA:0001917") +AnnotationAssertion( "SCTID:145137009") +AnnotationAssertion( "Wikipedia:Superior_labial_artery") +AnnotationAssertion(rdfs:label "artery of upper lip") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (artery of lower lip) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Inferior_labial_artery") "The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery.") +AnnotationAssertion( "FMA:49567") +AnnotationAssertion( "MA:0001916") +AnnotationAssertion( "SCTID:145036002") +AnnotationAssertion( "Wikipedia:Inferior_labial_artery") AnnotationAssertion(rdfs:label "artery of lower lip") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33862,6 +51577,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic cavity artery) +AnnotationAssertion(Annotation( "https://sourceforge.net/tracker/index.php?func=detail&aid=3317815&group_id=76834&atid=1205376") "An artery that is part of a thoracic cavity[cjm].") +AnnotationAssertion( "MA:0001902") +AnnotationAssertion( "MESH:D013895") AnnotationAssertion(rdfs:label "thoracic cavity artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33869,14 +51587,33 @@ SubClassOf( (respiratory system venous blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vein that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001809") +AnnotationAssertion( "MA:0001810") AnnotationAssertion(rdfs:label "respiratory system venous blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (vein of upper lip) + +AnnotationAssertion(Annotation( "Wikipedia:Superior_labial_vein") "The inferior labial vein is the vein receiving blood from the upper lip.") +AnnotationAssertion( "FMA:52538") +AnnotationAssertion( "MA:0002255") +AnnotationAssertion( "SCTID:422755007") +AnnotationAssertion( "Wikipedia:Superior_labial_vein") +AnnotationAssertion(rdfs:label "vein of upper lip") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vein of lower lip) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Inferior_labial_vein") "The inferior labial vein is the vein receiving blood from the lower lip.") +AnnotationAssertion( "FMA:52541") +AnnotationAssertion( "MA:0002253") +AnnotationAssertion( "SCTID:422955002") +AnnotationAssertion( "Wikipedia:Inferior_labial_vein") AnnotationAssertion(rdfs:label "vein of lower lip") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33884,13 +51621,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic cavity vein) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vein that is part of a thoracic cavity [Automatically generated definition].") +AnnotationAssertion( "MA:0001903") AnnotationAssertion(rdfs:label "thoracic cavity vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (tail vein) + +AnnotationAssertion(Annotation( "OBOL:automatic") Annotation( "Wikipedia:Tail_vein") "A vein that is part of a tail [Automatically generated definition].") +AnnotationAssertion( "AAO:0011105") +AnnotationAssertion( "MA:0002233") +AnnotationAssertion( "Wikipedia:Tail_vein") +AnnotationAssertion( "XAO:0000393") +AnnotationAssertion(rdfs:label "tail vein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (respiratory system capillary endothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium of capillary that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001808") AnnotationAssertion(rdfs:label "respiratory system capillary endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33899,6 +51652,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system venule) +AnnotationAssertion(Annotation( "OBOL:automatic") "A venule that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001813") AnnotationAssertion(rdfs:label "respiratory system venule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33906,6 +51661,8 @@ SubClassOf( (respiratory system arteriole) +AnnotationAssertion(Annotation( "OBOL:automatic") "An arteriole that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001803") AnnotationAssertion(rdfs:label "respiratory system arteriole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33914,6 +51671,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (head blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a head [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36610") +AnnotationAssertion( "MA:0000575") +AnnotationAssertion( "SCTID:127865000") AnnotationAssertion(rdfs:label "head blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33921,6 +51682,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdomen blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of an abdomen [Automatically generated definition].") +AnnotationAssertion( "MA:0000518") AnnotationAssertion(rdfs:label "abdomen blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33928,6 +51691,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a heart [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35397") +AnnotationAssertion( "MA:0002483") AnnotationAssertion(rdfs:label "heart blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33936,6 +51702,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (brain blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a brain [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35182") +AnnotationAssertion( "MA:0002769") AnnotationAssertion(rdfs:label "brain blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33944,6 +51713,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (corneal blood vessel) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") Annotation( "https://sourceforge.net/tracker/index.php?func=detail&aid=3564332&group_id=36855&atid=440764") "A blood vessel that is part of a cornea [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36611") +AnnotationAssertion( "MA:0001241") AnnotationAssertion(rdfs:label "corneal blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33952,6 +51724,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (retina blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a retina [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36520") +AnnotationAssertion( "GAID:509") +AnnotationAssertion( "MA:0001317") +AnnotationAssertion( "MESH:D012171") +AnnotationAssertion( "SCTID:280692003") +AnnotationAssertion( "XAO:0004153") AnnotationAssertion(rdfs:label "retina blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33961,6 +51740,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neck blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a neck [Automatically generated definition].") +AnnotationAssertion( "MA:0000583") AnnotationAssertion(rdfs:label "neck blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33968,6 +51749,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35731") +AnnotationAssertion( "EMAPA:35995") +AnnotationAssertion( "MA:0001799") AnnotationAssertion(rdfs:label "respiratory system blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33975,6 +51760,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trachea blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a trachea.") +AnnotationAssertion( "EMAPA:35874") +AnnotationAssertion( "MA:0001852") AnnotationAssertion(rdfs:label "trachea blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33983,6 +51771,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (arterial blood vessel) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta.") +AnnotationAssertion( "EMAPA:35144") +AnnotationAssertion( "MA:0000061") +AnnotationAssertion(rdfs:comment "only in MA - supertype of artery, arteriole, aorta.") AnnotationAssertion(rdfs:label "arterial blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33990,6 +51782,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (iris blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a iris [Automatically generated definition].") +AnnotationAssertion( "MA:0001290") AnnotationAssertion(rdfs:label "iris blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -33998,6 +51792,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:32867") +AnnotationAssertion( "MA:0002457") AnnotationAssertion(rdfs:label "lung blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34008,6 +51805,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trunk blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a trunk [Automatically generated definition].") +AnnotationAssertion( "MA:0000511") AnnotationAssertion(rdfs:label "trunk blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34015,13 +51814,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic cavity blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a thoracic cavity [Automatically generated definition].") +AnnotationAssertion( "MA:0000554") AnnotationAssertion(rdfs:label "thoracic cavity blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (tail blood vessel) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a tail [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35848") +AnnotationAssertion( "MA:0000695") +AnnotationAssertion(rdfs:label "tail blood vessel") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (respiratory system capillary) +AnnotationAssertion(Annotation( "OBOL:automatic") "A capillary that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001807") AnnotationAssertion(rdfs:label "respiratory system capillary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34029,13 +51842,32 @@ SubClassOf( (brain gray matter) +AnnotationAssertion(Annotation( "OBOL:automatic") "A gray matter that is part of a brain [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35184") +AnnotationAssertion( "MA:0000810") +AnnotationAssertion( "NCIT:C49333") AnnotationAssertion(rdfs:label "brain gray matter") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (tail skin) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a tail [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36502") +AnnotationAssertion( "MA:0000700") +AnnotationAssertion( "SCTID:67214004") +AnnotationAssertion(rdfs:label "tail skin") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (right lung alveolar duct) +AnnotationAssertion(Annotation( "OBOL:automatic") "An alveolar duct that is part of a right lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35819") +AnnotationAssertion( "MA:0001785") +AnnotationAssertion( "NCIT:C49277") AnnotationAssertion(rdfs:label "right lung alveolar duct") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34043,6 +51875,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left lung alveolar duct) +AnnotationAssertion(Annotation( "OBOL:automatic") "An alveolar duct that is part of a left lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:19183") +AnnotationAssertion( "MA:0001776") +AnnotationAssertion( "NCIT:C49250") +AnnotationAssertion(rdfs:comment "Mice have 1 left lobe") AnnotationAssertion(rdfs:label "left lung alveolar duct") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34050,6 +51887,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right lung bronchiole) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bronchiole that is part of a right lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35425") +AnnotationAssertion( "MA:0001787") +AnnotationAssertion( "NCIT:C49279") +AnnotationAssertion( "SCTID:200089000") AnnotationAssertion(rdfs:label "right lung bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34057,6 +51899,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left lung bronchiole) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bronchiole that is part of a left lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:19000") +AnnotationAssertion( "MA:0001778") +AnnotationAssertion( "NCIT:C49252") +AnnotationAssertion( "SCTID:200484003") AnnotationAssertion(rdfs:label "left lung bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34064,6 +51911,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right lung terminal bronchiole) +AnnotationAssertion(Annotation( "OBOL:automatic") "A terminal bronchiole that is part of a right lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36638") +AnnotationAssertion( "MA:0001789") +AnnotationAssertion( "NCIT:C49294") AnnotationAssertion(rdfs:label "right lung terminal bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34071,6 +51922,10 @@ SubClassOf( (left lung terminal bronchiole) +AnnotationAssertion(Annotation( "OBOL:automatic") "A terminal bronchiole that is part of a left lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36636") +AnnotationAssertion( "MA:0001780") +AnnotationAssertion( "NCIT:C49255") AnnotationAssertion(rdfs:label "left lung terminal bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34078,6 +51933,10 @@ SubClassOf( (right lung respiratory bronchiole) +AnnotationAssertion(Annotation( "OBOL:automatic") "A respiratory bronchiole that is part of a right lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36637") +AnnotationAssertion( "MA:0001788") +AnnotationAssertion( "NCIT:C49285") AnnotationAssertion(rdfs:label "right lung respiratory bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34085,6 +51944,10 @@ SubClassOf( (left lung respiratory bronchiole) +AnnotationAssertion(Annotation( "OBOL:automatic") "A respiratory bronchiole that is part of a left lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36635") +AnnotationAssertion( "MA:0001779") +AnnotationAssertion( "NCIT:C49254") AnnotationAssertion(rdfs:label "left lung respiratory bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34092,6 +51955,8 @@ SubClassOf( (head connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a head [Automatically generated definition].") +AnnotationAssertion( "MA:0000577") AnnotationAssertion(rdfs:label "head connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34100,6 +51965,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdomen connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of an abdomen [Automatically generated definition].") +AnnotationAssertion( "MA:0000519") AnnotationAssertion(rdfs:label "abdomen connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34107,6 +51974,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neck connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a neck [Automatically generated definition].") +AnnotationAssertion( "MA:0000585") AnnotationAssertion(rdfs:label "neck connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34114,6 +51983,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35968") +AnnotationAssertion( "EMAPA:35977") +AnnotationAssertion( "MA:0001814") AnnotationAssertion(rdfs:label "respiratory system connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34121,7 +51994,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trachea connective tissue) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a trachea.") +AnnotationAssertion( "EMAPA:35876") +AnnotationAssertion( "MA:0001853") AnnotationAssertion(rdfs:label "trachea connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34130,6 +52005,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lower respiratory tract connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition].") +AnnotationAssertion( "MA:0002409") AnnotationAssertion(rdfs:label "lower respiratory tract connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34138,6 +52015,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dermis connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a dermis [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36509") +AnnotationAssertion( "MA:0000799") AnnotationAssertion(rdfs:label "dermis connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34147,6 +52027,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trunk connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a trunk [Automatically generated definition].") +AnnotationAssertion( "MA:0000513") AnnotationAssertion(rdfs:label "trunk connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34154,6 +52036,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bronchus connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a bronchus [Automatically generated definition].") +AnnotationAssertion( "EMAPA:32690") +AnnotationAssertion( "EMAPA:35193") +AnnotationAssertion( "MA:0001831") +AnnotationAssertion( "NCIT:C49210") AnnotationAssertion(rdfs:label "bronchus connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34161,13 +52048,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic cavity connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition].") +AnnotationAssertion( "MA:0000555") AnnotationAssertion(rdfs:label "thoracic cavity connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (tail connective tissue) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a tail [Automatically generated definition].") +AnnotationAssertion( "EMAPA:16749") +AnnotationAssertion( "MA:0000697") +AnnotationAssertion(rdfs:label "tail connective tissue") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (neck cartilage) +AnnotationAssertion(Annotation( "OBOL:automatic") "A cartilage that is part of a neck [Automatically generated definition].") +AnnotationAssertion( "MA:0000586") AnnotationAssertion(rdfs:label "neck cartilage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34175,6 +52076,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lower respiratory tract cartilage) +AnnotationAssertion(Annotation( "OBOL:automatic") "A cartilage that is part of a lower respiratory tract [Automatically generated definition].") +AnnotationAssertion( "MA:0001819") +AnnotationAssertion( "NCIT:C49256") AnnotationAssertion(rdfs:label "lower respiratory tract cartilage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34183,7 +52087,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trachea cartilage) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "J:97123") Annotation( "MGI:smb") Annotation( "MP:0003120") Annotation( "http://orcid.org/0000-0002-6601-2165") "The ring-shaped cartilaginous structures that support the trachea.") +AnnotationAssertion( "EMAPA:18699") +AnnotationAssertion( "EMAPA:35875") +AnnotationAssertion( "FMA:7434") +AnnotationAssertion( "MA:0001857") +AnnotationAssertion( "NCIT:C49304") +AnnotationAssertion( "SCTID:278979006") +AnnotationAssertion( "Wikipedia:Tracheal_rings") AnnotationAssertion(rdfs:label "trachea cartilage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34192,6 +52103,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (eye skin gland) +AnnotationAssertion(Annotation( "OBOL:automatic") "A skin gland that is part of a camera-type eye [Automatically generated definition].") +AnnotationAssertion( "MA:0002451") AnnotationAssertion(rdfs:label "eye skin gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34201,6 +52114,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aorta elastic tissue) +AnnotationAssertion(Annotation( "MP:0009862") "The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall.") +AnnotationAssertion( "MA:0002859") AnnotationAssertion(rdfs:label "aorta elastic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34208,6 +52123,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart elastic tissue) +AnnotationAssertion(Annotation( "MP:0009863") "The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers.") +AnnotationAssertion( "MA:0002858") AnnotationAssertion(rdfs:label "heart elastic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34217,6 +52134,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system elastic tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "An elastic tissue that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001820") AnnotationAssertion(rdfs:label "respiratory system elastic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34225,6 +52144,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiovascular system elastic tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "An elastic tissue that is part of a circulatory system [Automatically generated definition].") +AnnotationAssertion( "MA:0002857") AnnotationAssertion(rdfs:label "cardiovascular system elastic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34232,6 +52153,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (blood vessel elastic tissue) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://sourceforge.net/p/obo/mammalian-phenotype-requests/2026/") "Elastic tissue layer that lines a blood vessel layer.") +AnnotationAssertion( "EMAPA:36300") +AnnotationAssertion( "MA:0002856") AnnotationAssertion(rdfs:label "blood vessel elastic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34240,6 +52164,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung elastic tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "Elastic tissue that is part of a lung [Automatically generated definition].") +AnnotationAssertion( "MA:0002860") AnnotationAssertion(rdfs:label "lung elastic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34247,6 +52173,9 @@ SubClassOf( (bronchus elastic tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "An elastic tissue that is part of a bronchus [Automatically generated definition].") +AnnotationAssertion( "MA:0001838") +AnnotationAssertion( "NCIT:C49211") AnnotationAssertion(rdfs:label "bronchus elastic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34255,7 +52184,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trachea elastic tissue) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "An elastic tissue that is part of a trachea [Automatically generated definition].") +AnnotationAssertion( "MA:0001861") AnnotationAssertion(rdfs:label "trachea elastic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34264,6 +52194,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aorta tunica media) +AnnotationAssertion(Annotation( "MP:0009873") "The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers.") +AnnotationAssertion( "EMAPA:35138") +AnnotationAssertion( "FMA:74433") +AnnotationAssertion( "MA:0002903") +AnnotationAssertion( "SCTID:48467007") AnnotationAssertion(rdfs:label "aorta tunica media") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34272,6 +52207,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aorta tunica intima) +AnnotationAssertion(Annotation( "MP:0009872") "The innermost layer of the aorta, containing the endothelium and an inner elastic membrane.") +AnnotationAssertion( "BTO:0005553") +AnnotationAssertion( "EMAPA:35137") +AnnotationAssertion( "FMA:74419") +AnnotationAssertion( "MA:0002904") +AnnotationAssertion( "SCTID:362031007") AnnotationAssertion(rdfs:label "aorta tunica intima") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34281,13 +52222,39 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system arterial blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "An arterial blood vessel that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001800") AnnotationAssertion(rdfs:label "respiratory system arterial blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (post-anal tail muscle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscle organ that attaches to a tail vertebra [Automatically generated definition].") +AnnotationAssertion( "AAO:0000081") +AnnotationAssertion( "BTO:0001905") +AnnotationAssertion( "MA:0000699") +AnnotationAssertion( "SCTID:113230005") +AnnotationAssertion(rdfs:label "post-anal tail muscle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (abdominal cavity) +AnnotationAssertion(Annotation( "UBERON:cjm") "The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity).") +AnnotationAssertion( "EFO:0000213") +AnnotationAssertion( "EMAPA:36505") +AnnotationAssertion( "FMA:12266") +AnnotationAssertion( "GAID:17") +AnnotationAssertion( "MA:0003057") +AnnotationAssertion( "MESH:D034841") +AnnotationAssertion( "NCIT:C12664") +AnnotationAssertion( "SCTID:361294009") +AnnotationAssertion( "Wikipedia:Abdominal_cavity") +AnnotationAssertion( "galen:AbdominalCavity") AnnotationAssertion(rdfs:label "abdominal cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34296,29 +52263,126 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (foramen magnum) +AnnotationAssertion(Annotation( "Wikipedia:Foramen_magnum") "In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted].") +AnnotationAssertion( "AAO:0010826") +AnnotationAssertion( "FMA:75306") +AnnotationAssertion( "GAID:228") +AnnotationAssertion( "MESH:D005539") +AnnotationAssertion( "NCIT:C12495") +AnnotationAssertion( "SCTID:244679008") +AnnotationAssertion( "TAO:0002045") +AnnotationAssertion( "Wikipedia:Foramen_magnum") +AnnotationAssertion( "ZFA:0005387") +AnnotationAssertion(rdfs:comment "Design pattern notes: check whether this fits the foramen design pattern") AnnotationAssertion(rdfs:label "foramen magnum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (atlanto-axial joint) + +AnnotationAssertion(Annotation( "Wikipedia:Atlanto-axial_joint") "The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas.") +AnnotationAssertion( "FMA:25524") +AnnotationAssertion( "GAID:250") +AnnotationAssertion( "MESH:D001268") +AnnotationAssertion( "NCIT:C32157") +AnnotationAssertion( "SCTID:361832004") +AnnotationAssertion( "Wikipedia:Atlanto-axial_joint") +AnnotationAssertion(rdfs:label "atlanto-axial joint") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (abdominal wall) +AnnotationAssertion(Annotation( "ncithesaurus:Abdominal_Wall") "The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles.") +AnnotationAssertion( "FMA:10429") +AnnotationAssertion( "FMA:259054") +AnnotationAssertion( "GAID:26") +AnnotationAssertion( "MESH:D034861") +AnnotationAssertion( "NCIT:C77608") +AnnotationAssertion( "SCTID:181613000") +AnnotationAssertion( "Wikipedia:Abdominal_wall") AnnotationAssertion(rdfs:label "abdominal wall") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (extrahepatic bile duct) + +AnnotationAssertion(Annotation( "MESH:A03.159.183.079") "Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct.") +AnnotationAssertion( "FMA:14678") +AnnotationAssertion( "GAID:281") +AnnotationAssertion( "MA:0002659") +AnnotationAssertion( "MESH:D017734") +AnnotationAssertion( "NCIT:C32573") +AnnotationAssertion( "SCTID:276158002") +AnnotationAssertion(rdfs:label "extrahepatic bile duct") +SubClassOf( ) + +# Class: (intrahepatic bile duct) + +AnnotationAssertion(Annotation( "MESH:A03.159.183.158") "Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.") +AnnotationAssertion( "FMA:15766") +AnnotationAssertion( "GAID:287") +AnnotationAssertion( "MA:0001630") +AnnotationAssertion( "MESH:D001653") +AnnotationAssertion( "NCIT:C12677") +AnnotationAssertion( "SCTID:362193005") +AnnotationAssertion( "TAO:0005169") +AnnotationAssertion( "ZFA:0005169") +AnnotationAssertion(rdfs:label "intrahepatic bile duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (brachiocephalic vein) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Brachiocephalic_vein") "The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava.") +AnnotationAssertion( "EHDAA2:0000182") +AnnotationAssertion( "EHDAA:9868") +AnnotationAssertion( "FMA:4723") +AnnotationAssertion( "GAID:529") +AnnotationAssertion( "MESH:D016121") +AnnotationAssertion( "NCIT:C32816") +AnnotationAssertion( "SCTID:181371003") +AnnotationAssertion( "Wikipedia:Brachiocephalic_vein") +AnnotationAssertion( "galen:BrachiocephalicVein") AnnotationAssertion(rdfs:label "brachiocephalic vein") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (splenic vein) + +AnnotationAssertion(Annotation( "ncithesaurus:Splenic_Vein") "A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein.") +AnnotationAssertion( "FMA:14331") +AnnotationAssertion( "GAID:541") +AnnotationAssertion( "MA:0002164") +AnnotationAssertion( "MESH:D013162") +AnnotationAssertion( "NCIT:C33608") +AnnotationAssertion( "SCTID:278029005") +AnnotationAssertion( "Wikipedia:Splenic_vein") +AnnotationAssertion( "galen:SplenicVein") +AnnotationAssertion(rdfs:label "splenic vein") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (neural tissue) +AnnotationAssertion(Annotation( "FMA:9642") "Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature.") +AnnotationAssertion( "AAO:0000325") +AnnotationAssertion( "AEO:0000123") +AnnotationAssertion( "EHDAA2:0003123") +AnnotationAssertion( "FMA:9642") +AnnotationAssertion( "GAID:609") +AnnotationAssertion( "MESH:D009417") +AnnotationAssertion( "NCIT:C13052") +AnnotationAssertion( "SCTID:91728009") AnnotationAssertion(rdfs:label "neural tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34329,7 +52393,13 @@ DisjointClasses( (splanchnic nerve) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MP:0008318") "The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia.") +AnnotationAssertion( "BAMS:spn") +AnnotationAssertion( "FMA:5883") +AnnotationAssertion( "GAID:800") +AnnotationAssertion( "MESH:D013153") +AnnotationAssertion( "SCTID:264198001") +AnnotationAssertion( "Wikipedia:Splanchnic_nerves") AnnotationAssertion(rdfs:label "splanchnic nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34338,7 +52408,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic nerve) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MESH:A08.800.800.720.800") "The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls.") +AnnotationAssertion( "FMA:5860") +AnnotationAssertion( "GAID:857") +AnnotationAssertion( "MESH:D013900") +AnnotationAssertion( "SCTID:360498003") +AnnotationAssertion( "Wikipedia:Thoracic_nerves") +AnnotationAssertion( "neuronames:1725") AnnotationAssertion(rdfs:label "thoracic nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34346,11 +52422,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (intercostal nerve) +AnnotationAssertion(Annotation( "Wikipedia:Intercostal_nerves") "The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted].") +AnnotationAssertion( "EMAPA:18227") +AnnotationAssertion( "FMA:6028") +AnnotationAssertion( "GAID:858") +AnnotationAssertion( "MESH:D007367") +AnnotationAssertion( "NCIT:C32825") +AnnotationAssertion( "SCTID:279568001") +AnnotationAssertion( "Wikipedia:Intercostal_nerves") AnnotationAssertion(rdfs:label "intercostal nerve") SubClassOf( ) # Class: (mouth mucosa) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A mucous membrane that lines the mouth.") +AnnotationAssertion( "BTO:0002860") +AnnotationAssertion( "CALOHA:TS-0716") +AnnotationAssertion( "EMAPA:26937") +AnnotationAssertion( "FMA:59660") +AnnotationAssertion( "GAID:951") +AnnotationAssertion( "MA:0002794") +AnnotationAssertion( "MESH:D009061") +AnnotationAssertion( "NCIT:C77637") +AnnotationAssertion( "Wikipedia:Oral_mucosa") AnnotationAssertion(rdfs:label "mouth mucosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34362,6 +52456,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nerve of thoracic segment) +AnnotationAssertion(Annotation( "OBOL:automatic") "A nerve that is part of a thorax [Automatically generated definition].") +AnnotationAssertion( "MA:0000562") +AnnotationAssertion( "MESH:D013900") +AnnotationAssertion( "SCTID:359876006") AnnotationAssertion(rdfs:label "nerve of thoracic segment") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34369,6 +52467,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nerve of abdominal segment) +AnnotationAssertion(Annotation( "OBOL:automatic") "A nerve that is part of an abdominal segment of trunk [Automatically generated definition].") +AnnotationAssertion( "MA:0000528") AnnotationAssertion(rdfs:label "nerve of abdominal segment") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34376,6 +52476,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic segment bone) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of a thorax [Automatically generated definition].") +AnnotationAssertion( "MA:0000559") +AnnotationAssertion( "SCTID:426649006") AnnotationAssertion(rdfs:label "thoracic segment bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34383,6 +52486,8 @@ SubClassOf( (abdominal segment bone) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of an abdominal segment of trunk [Automatically generated definition].") +AnnotationAssertion( "MA:0000525") AnnotationAssertion(rdfs:label "abdominal segment bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34390,6 +52495,8 @@ SubClassOf( (thoracic segment muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a thorax [Automatically generated definition].") +AnnotationAssertion( "MA:0000561") AnnotationAssertion(rdfs:label "thoracic segment muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34398,6 +52505,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35733") +AnnotationAssertion( "MA:0001828") AnnotationAssertion(rdfs:label "respiratory system muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34405,6 +52515,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (esophagus muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a esophagus [Automatically generated definition].") +AnnotationAssertion( "EMAPA:26983") +AnnotationAssertion( "MA:0002682") +AnnotationAssertion( "SCTID:360961009") AnnotationAssertion(rdfs:label "esophagus muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34414,6 +52528,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdominal segment muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition].") +AnnotationAssertion( "MA:0000527") AnnotationAssertion(rdfs:label "abdominal segment muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34421,6 +52537,8 @@ SubClassOf( (thoracic segment blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a thorax [Automatically generated definition].") +AnnotationAssertion( "MA:0000558") AnnotationAssertion(rdfs:label "thoracic segment blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34428,6 +52546,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdominal segment blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition].") +AnnotationAssertion( "MA:0000524") AnnotationAssertion(rdfs:label "abdominal segment blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34435,6 +52555,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdominal segment skin) +AnnotationAssertion(Annotation( "OBOL:automatic") "A skin of body that is part of an abdominal segment of trunk [Automatically generated definition].") +AnnotationAssertion( "FMA:264898") +AnnotationAssertion( "MA:0000530") AnnotationAssertion(rdfs:label "abdominal segment skin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34442,6 +52565,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic segment connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a thorax [Automatically generated definition].") +AnnotationAssertion( "MA:0000560") AnnotationAssertion(rdfs:label "thoracic segment connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34449,6 +52574,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdominal segment connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition].") +AnnotationAssertion( "MA:0000526") AnnotationAssertion(rdfs:label "abdominal segment connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34456,6 +52583,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural tube lumen) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that surrounded_by a neural tube.") +AnnotationAssertion( "AAO:0011073") +AnnotationAssertion( "EHDAA2:0001269") +AnnotationAssertion( "EHDAA:2889") +AnnotationAssertion( "EHDAA:914") +AnnotationAssertion( "EMAPA:16167") +AnnotationAssertion( "VHOG:0001119") +AnnotationAssertion( "XAO:0000252") AnnotationAssertion(rdfs:label "neural tube lumen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34464,6 +52599,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gonadal vein) +AnnotationAssertion(Annotation( "Wikipedia:Gonadal_vein") "In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted].") +AnnotationAssertion( "EHDAA2:0000719") +AnnotationAssertion( "EHDAA:8703") +AnnotationAssertion( "SCTID:278192008") +AnnotationAssertion( "VHOG:0001340") +AnnotationAssertion( "Wikipedia:Gonadal_vein") AnnotationAssertion(rdfs:label "gonadal vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34471,6 +52612,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesencephalic neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "A neural crest that has_potential_to_developmentally_contribute_to a midbrain.") +AnnotationAssertion( "EFO:0003591") +AnnotationAssertion( "EHDAA2:0001101") +AnnotationAssertion( "EHDAA:360") +AnnotationAssertion( "TAO:0000935") +AnnotationAssertion( "VHOG:0000796") +AnnotationAssertion( "ZFA:0000935") AnnotationAssertion(rdfs:label "mesencephalic neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34479,6 +52627,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (rhombencephalon neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "A neural crest that has_potential_to_developmentally_contribute_to a hindbrain.") +AnnotationAssertion( "EHDAA2:0001628") +AnnotationAssertion( "EHDAA:362") +AnnotationAssertion( "EMAPA:35747") +AnnotationAssertion( "TAO:0007063") +AnnotationAssertion( "VHOG:0001210") +AnnotationAssertion( "ZFA:0007063") AnnotationAssertion(rdfs:label "rhombencephalon neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34487,6 +52642,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (spinal cord neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "A neural crest that has_potential_to_developmentally_contribute_to a spinal cord.") +AnnotationAssertion( "EHDAA:696") +AnnotationAssertion( "EMAPA:16163") +AnnotationAssertion( "EMAPA:16881") +AnnotationAssertion( "VHOG:0001006") AnnotationAssertion(rdfs:label "spinal cord neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34494,6 +52654,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (spinal cord neural plate) +AnnotationAssertion(Annotation( "OBOL:automatic") "A neural plate that develops_from a future spinal cord.") +AnnotationAssertion( "FMA:312957") +AnnotationAssertion( "TAO:0007021") +AnnotationAssertion( "VHOG:0000439") +AnnotationAssertion( "ZFA:0007021") AnnotationAssertion(rdfs:label "spinal cord neural plate") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34501,6 +52666,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gonad mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing gonad [Automatically generated definition].") +AnnotationAssertion( "EHDAA:5012") +AnnotationAssertion( "EMAPA:16858") +AnnotationAssertion( "EMAPA:17385") +AnnotationAssertion( "VHOG:0001090") AnnotationAssertion(rdfs:label "gonad mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34509,6 +52679,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive ganglion) +AnnotationAssertion(Annotation( "OBOL:automatic") "A presumptive structure that has the potential to develop into a ganglion.") AnnotationAssertion(rdfs:label "presumptive ganglion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34516,6 +52687,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future coelemic cavity lumen) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that has the potential to develop into a coelemic cavity lumen.") AnnotationAssertion(rdfs:label "future coelemic cavity lumen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34526,6 +52698,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (intraembryonic coelom) +AnnotationAssertion(Annotation( "MGI:anna") Annotation( "MP:0012187") "The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.") +AnnotationAssertion( "EHDAA:251") +AnnotationAssertion( "EMAPA:16088") +AnnotationAssertion( "NCIT:C34195") +AnnotationAssertion( "VHOG:0000316") +AnnotationAssertion( "Wikipedia:Intraembryonic_coelom") AnnotationAssertion(rdfs:label "intraembryonic coelom") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -34533,13 +52711,43 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (stroma) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma.") +AnnotationAssertion( "FMA:81494") +AnnotationAssertion( "NCIT:C67387") AnnotationAssertion(rdfs:label "stroma") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (liver primordium) + +AnnotationAssertion(Annotation( "ISBN:3211492755") "A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum.") +AnnotationAssertion( "AAO:0011058") +AnnotationAssertion( "BTO:0003391") +AnnotationAssertion( "EFO:0002577") +AnnotationAssertion( "EFO:0003428") +AnnotationAssertion( "EHDAA2:0000744") +AnnotationAssertion( "EHDAA:973") +AnnotationAssertion( "EMAPA:16847") +AnnotationAssertion( "NCIT:C34277") +AnnotationAssertion( "TAO:0000124") +AnnotationAssertion( "XAO:0003266") +AnnotationAssertion( "ZFA:0000124") +AnnotationAssertion(rdfs:label "liver primordium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (skeletal muscle tissue of trunk) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A portion of skeletal muscle tissue in the trunk.") +AnnotationAssertion( "SCTID:244848007") AnnotationAssertion(rdfs:label "skeletal muscle tissue of trunk") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34548,7 +52756,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (retinal neural layer) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0003407") "The part of the retina that contains neurons and photoreceptor cells[GO].") +AnnotationAssertion( "AAO:0011095") +AnnotationAssertion( "BTO:0000929") +AnnotationAssertion( "CALOHA:TS-0685") +AnnotationAssertion( "EHDAA2:0001253") +AnnotationAssertion( "EHDAA:4763") +AnnotationAssertion( "EMAPA:17171") +AnnotationAssertion( "EMAPA:18590") +AnnotationAssertion( "FMA:58628") +AnnotationAssertion( "MA:0000277") +AnnotationAssertion( "NCIT:C33166") +AnnotationAssertion( "TAO:0000046") +AnnotationAssertion( "VHOG:0000535") +AnnotationAssertion( "XAO:0003216") +AnnotationAssertion( "ZFA:0000046") AnnotationAssertion(rdfs:label "retinal neural layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34558,11 +52780,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sinusoid) +AnnotationAssertion(Annotation( "Wikipedia:Sinusoid_(blood_vessel)") "Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP].") +AnnotationAssertion( "FMA:63131") +AnnotationAssertion( "SCTID:340163004") +AnnotationAssertion( "TAO:0005261") +AnnotationAssertion( "Wikipedia:Sinusoid_(blood_vessel)") +AnnotationAssertion( "ZFA:0005261") AnnotationAssertion(rdfs:label "sinusoid") SubClassOf( ) # Class: (epithelial tube) +AnnotationAssertion(Annotation( "GO:0060562") Annotation( "PMID:12526790") "Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.") +AnnotationAssertion( "AEO:0000114") +AnnotationAssertion( "EHDAA2:0003114") AnnotationAssertion(rdfs:label "epithelial tube") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34570,6 +52801,7 @@ SubClassOf( (endothelial tube) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any endothelium that has the quality of being cylindrical [Automatically generated definition].") AnnotationAssertion(rdfs:label "endothelial tube") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34577,14 +52809,97 @@ SubClassOf( (venous blood vessel) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://www.thefreedictionary.com/venous+blood+vessel") "A blood vessel that carries blood from the capillaries toward the heart.") +AnnotationAssertion( "EMAPA:35932") +AnnotationAssertion( "FMA:86188") +AnnotationAssertion( "MA:0000066") +AnnotationAssertion(rdfs:comment "Compare to: vein") AnnotationAssertion(rdfs:label "venous blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreas primordium) + +AnnotationAssertion(Annotation( "Wikipedia:Pancreas#Embryological_development") "Embryonic structure that develops into pancreatic bud.") +AnnotationAssertion( "EFO:0002579") +AnnotationAssertion( "EFO:0003434") +AnnotationAssertion( "EHDAA2:0001382") +AnnotationAssertion( "EHDAA:2163") +AnnotationAssertion( "EMAPA:17066") +AnnotationAssertion( "FMA:79792") +AnnotationAssertion( "TAO:0000254") +AnnotationAssertion( "XAO:0001101") +AnnotationAssertion( "ZFA:0000254") +AnnotationAssertion(rdfs:label "pancreas primordium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreatic epithelial bud) + +AnnotationAssertion(Annotation( "PMID:16417468") Annotation( "Wikipedia:Pancreatic_bud") "The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID].") +AnnotationAssertion( "EFO:0003470") +AnnotationAssertion( "EMAPA:35645") +AnnotationAssertion( "NCIT:C34242") +AnnotationAssertion( "SCTID:360398004") +AnnotationAssertion( "TAO:0001390") +AnnotationAssertion( "Wikipedia:Pancreatic_bud") +AnnotationAssertion( "ZFA:0001390") +AnnotationAssertion(rdfs:label "pancreatic epithelial bud") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (dorsal pancreatic bud) + +AnnotationAssertion(Annotation( "Wikipedia:Pancreatic_bud") "Pancreatic bud that gives rise to the accessory pancreatic duct.") +AnnotationAssertion( "AAO:0011031") +AnnotationAssertion( "EFO:0003465") +AnnotationAssertion( "EHDAA2:0001385") +AnnotationAssertion( "EMAPA:17067") +AnnotationAssertion( "SCTID:361435005") +AnnotationAssertion( "TAO:0001370") +AnnotationAssertion( "VHOG:0001428") +AnnotationAssertion( "Wikipedia:Pancreatic_bud") +AnnotationAssertion( "XAO:0000467") +AnnotationAssertion( "ZFA:0001370") +AnnotationAssertion(rdfs:label "dorsal pancreatic bud") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (ventral pancreatic bud) + +AnnotationAssertion(Annotation( "Wikipedia:Pancreatic_bud") "Pancreatic bud that gives rise to the major pancreatic duct.") +AnnotationAssertion( "AAO:0011111") +AnnotationAssertion( "EFO:0003464") +AnnotationAssertion( "EHDAA2:0001389") +AnnotationAssertion( "EMAPA:17256") +AnnotationAssertion( "SCTID:361437002") +AnnotationAssertion( "TAO:0001369") +AnnotationAssertion( "VHOG:0001429") +AnnotationAssertion( "Wikipedia:Pancreatic_bud") +AnnotationAssertion( "XAO:0001103") +AnnotationAssertion( "ZFA:0001369") +AnnotationAssertion(rdfs:label "ventral pancreatic bud") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (digestive system duct) +AnnotationAssertion(Annotation( "OBOL:automatic") "A duct that is part of a digestive system [Automatically generated definition].") +AnnotationAssertion( "TAO:0005162") +AnnotationAssertion( "ZFA:0005162") AnnotationAssertion(rdfs:label "digestive system duct") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34592,6 +52907,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (digestive tract epithelium) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An epithelium that lines the lumen of the digestive tract.") +AnnotationAssertion( "BTO:0000956") +AnnotationAssertion( "EHDAA2:0004567") +AnnotationAssertion( "EMAPA:32928") +AnnotationAssertion( "MA:0003201") +AnnotationAssertion( "NCIT:C12963") +AnnotationAssertion( "TAO:0005123") +AnnotationAssertion( "XAO:0003200") +AnnotationAssertion( "ZFA:0005123") AnnotationAssertion(rdfs:label "digestive tract epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34599,6 +52923,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cartilage element of chondrocranium) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A cartilage element of chondrocranium. Example: neurocranial trabecula.") +AnnotationAssertion( "EFO:0003690") +AnnotationAssertion( "TAO:0001461") +AnnotationAssertion( "ZFA:0001461") AnnotationAssertion(rdfs:label "cartilage element of chondrocranium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34606,6 +52934,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranial cartilage) +AnnotationAssertion(Annotation( "ZFA:0001458") Annotation( "https://orcid.org/0000-0002-6601-2165") "A cartilage element that is part of the cranial skeleton.") +AnnotationAssertion( "TAO:0001458") +AnnotationAssertion( "ZFA:0001458") AnnotationAssertion(rdfs:label "cranial cartilage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34613,6 +52944,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (reproductive gland) +AnnotationAssertion(Annotation( "MP:0000653") "Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction.") +AnnotationAssertion( "MA:0001751") AnnotationAssertion(rdfs:label "reproductive gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34620,6 +52953,10 @@ SubClassOf( (somatosensory system) +AnnotationAssertion(Annotation( "NLXANAT:090818") "The sensory system for the sense of touch and pain.") +AnnotationAssertion( "NLXANAT:090818") +AnnotationAssertion( "Wikipedia:Somatosensory_system") +AnnotationAssertion( "neuronames:2887") AnnotationAssertion(rdfs:label "somatosensory system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -34627,7 +52964,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anterior stroma of cornea) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MP:0003093") "The anterior segment of the lamellated connective tissue layer of the cornea.") AnnotationAssertion(rdfs:label "anterior stroma of cornea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34638,6 +52975,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (posterior stroma of cornea) +AnnotationAssertion(Annotation( "MP:0003094") "The posterior segment of the lamellated connective tissue layer of the cornea.") AnnotationAssertion(rdfs:label "posterior stroma of cornea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34648,6 +52986,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cutaneous elastic tissue) +AnnotationAssertion(Annotation( "MP:0008418") "The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity.") AnnotationAssertion(rdfs:label "cutaneous elastic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34657,7 +52996,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (internal female genitalia) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MP:0009209") "The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina.") +AnnotationAssertion( "BTO:0003099") +AnnotationAssertion( "FMA:45654") +AnnotationAssertion( "SCTID:303518005") +AnnotationAssertion(rdfs:comment "TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547") AnnotationAssertion(rdfs:label "internal female genitalia") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34665,6 +53008,7 @@ SubClassOf( (embryonic-extraembryonic boundary) +AnnotationAssertion(Annotation( "MP:0003890") "The connection between the embryo proper and extraembryonic tissues.") AnnotationAssertion(rdfs:label "embryonic-extraembryonic boundary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34673,12 +53017,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dermatome) +AnnotationAssertion(Annotation( "AEO:0001017") Annotation( "AEO:JB") "A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells.") +AnnotationAssertion( "AAO:0011028") +AnnotationAssertion( "AEO:0001017") +AnnotationAssertion( "EHDAA2_RETIRED:0003428") +AnnotationAssertion( "EHDAA:1719") +AnnotationAssertion( "EHDAA:1725") +AnnotationAssertion( "EHDAA:1731") +AnnotationAssertion( "EHDAA:1737") +AnnotationAssertion( "EMAPA:32838") +AnnotationAssertion( "FMA:295656") +AnnotationAssertion( "NCIT:C61572") +AnnotationAssertion( "Wikipedia:Dermatome_(embryology)") +AnnotationAssertion( "XAO:0000220") AnnotationAssertion(rdfs:label "dermatome") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (germinal neuroepithelium) +AnnotationAssertion(Annotation( "MP:0004261") Annotation( "http://www.ncbi.nlm.nih.gov/books/NBK10047") "The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells.") AnnotationAssertion(rdfs:label "germinal neuroepithelium") SubClassOf( ) SubClassOf( ) @@ -34688,8 +53046,26 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) DisjointClasses( ) +# Class: (biliary ductule) + +AnnotationAssertion(Annotation( "BTO:0002840") Annotation( "MP:0009494") "One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP].") +AnnotationAssertion( "BTO:0002840") +AnnotationAssertion( "TAO:0005164") +AnnotationAssertion( "ZFA:0005164") +AnnotationAssertion(rdfs:label "biliary ductule") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (neural tube ventricular layer) +AnnotationAssertion(Annotation( "MP:0009689") Annotation( "http://www.ncbi.nlm.nih.gov/books/NBK10047") "The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium.") +AnnotationAssertion( "EMAPA:17152") +AnnotationAssertion( "EMAPA:35362") +AnnotationAssertion( "EMAPA_RETIRED:16783") +AnnotationAssertion( "MA:0003193") AnnotationAssertion(rdfs:label "neural tube ventricular layer") SubClassOf( ) SubClassOf( ) @@ -34700,6 +53076,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural tube mantle layer) +AnnotationAssertion(Annotation( "MP:0009690") Annotation( "http://www.ncbi.nlm.nih.gov/books/NBK10047") "The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer.") +AnnotationAssertion( "EMAPA:17148") +AnnotationAssertion( "EMAPA:35360") +AnnotationAssertion( "neuronames:1367") AnnotationAssertion(rdfs:label "neural tube mantle layer") SubClassOf( ) SubClassOf( ) @@ -34711,6 +53091,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural tube marginal layer) +AnnotationAssertion(Annotation( "MP:0009691") Annotation( "http://www.ncbi.nlm.nih.gov/books/NBK10047") "The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter.") +AnnotationAssertion( "EMAPA:17151") +AnnotationAssertion( "neuronames:1368") AnnotationAssertion(rdfs:label "neural tube marginal layer") SubClassOf( ) SubClassOf( ) @@ -34720,6 +53103,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural tube basal plate) +AnnotationAssertion(Annotation( "MP:0009693") Annotation( "Wikipedia:Basal_plate_(neural_tube)") Annotation( "http://www.ncbi.nlm.nih.gov/books/NBK10047") "The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons.") +AnnotationAssertion( "AAO:0010561") +AnnotationAssertion( "EFO:0001904") +AnnotationAssertion( "NCIT:C34111") +AnnotationAssertion( "Wikipedia:Basal_plate_(neural_tube)") +AnnotationAssertion( "neuronames:1372") AnnotationAssertion(rdfs:label "neural tube basal plate") SubClassOf( ) SubClassOf( ) @@ -34729,23 +53118,81 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (frontonasal prominence) + +AnnotationAssertion(Annotation( "MP:0009901") "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout.") +AnnotationAssertion( "EHDAA2:0000578") +AnnotationAssertion( "EHDAA:4778") +AnnotationAssertion( "EMAPA:16681") +AnnotationAssertion( "FMA:293101") +AnnotationAssertion( "NCIT:C34182") +AnnotationAssertion( "SCTID:361486000") +AnnotationAssertion( "VHOG:0001319") +AnnotationAssertion( "Wikipedia:Frontonasal_prominence") +AnnotationAssertion(rdfs:label "frontonasal prominence") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (medial nasal prominence) + +AnnotationAssertion(Annotation( "MP:0009903") Annotation( "Wikipedia:Medial_nasal_prominence") "The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it.") +AnnotationAssertion( "EHDAA2:0001076") +AnnotationAssertion( "EHDAA:4792") +AnnotationAssertion( "EMAPA:16808") +AnnotationAssertion( "FMA:295858") +AnnotationAssertion( "SCTID:308877001") +AnnotationAssertion( "VHOG:0000804") +AnnotationAssertion( "Wikipedia:Medial_nasal_prominence") +AnnotationAssertion(rdfs:label "medial nasal prominence") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vena cava) +AnnotationAssertion(Annotation( "Wikipedia:Venae_cavae") Annotation( "http://orcid.org/0000-0002-6601-2165") "Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart.") +AnnotationAssertion( "AAO:0010215") +AnnotationAssertion( "BTO:0001438") +AnnotationAssertion( "EMAPA:18415") +AnnotationAssertion( "FMA:321896") +AnnotationAssertion( "GAID:547") +AnnotationAssertion( "MA:0000068") +AnnotationAssertion( "MESH:D014684") +AnnotationAssertion( "NCIT:C12817") +AnnotationAssertion( "SCTID:244405007") +AnnotationAssertion( "Wikipedia:Venae_cavae") AnnotationAssertion(rdfs:label "vena cava") SubClassOf( ) SubClassOf( ) # Class: (orbital region) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present.") +AnnotationAssertion( "FMA:260119") AnnotationAssertion(rdfs:label "orbital region") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (midface) + +AnnotationAssertion(Annotation( "HP:0000309") Annotation( "http://www.merriam-webster.com/medical/midface") "The middle of the face including the nose and its associated bony structures[MW].") +AnnotationAssertion( "FMA:285406") +AnnotationAssertion( "MA:0001910") +AnnotationAssertion(rdfs:label "midface") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (anatomical conduit) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any tube, opening or passage that connects two distinct anatomical spaces.") +AnnotationAssertion( "AEO:0000080") +AnnotationAssertion( "EHDAA2:0003080") +AnnotationAssertion( "FMA:242873") +AnnotationAssertion( "SCTID:346902003") +AnnotationAssertion( "Wikipedia:Foramen") AnnotationAssertion(rdfs:label "anatomical conduit") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34755,6 +53202,8 @@ SubClassOf( ObjectExactCardinalit # Class: (vasculature of iris) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vasculature that is part of a iris [Automatically generated definition].") +AnnotationAssertion( "ZFA:0005568") AnnotationAssertion(rdfs:label "vasculature of iris") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34762,6 +53211,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endoderm-derived structure) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An anatomical structure that develops (entirely or partially) from the endoderm.") AnnotationAssertion(rdfs:label "endoderm-derived structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34769,6 +53219,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesoderm-derived structure) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An anatomical structure that develops (entirely or partially) from the mesoderm.") AnnotationAssertion(rdfs:label "mesoderm-derived structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34776,13 +53227,86 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ectoderm-derived structure) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An anatomical structure that develops (entirely or partially) from the ectoderm.") AnnotationAssertion(rdfs:label "ectoderm-derived structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (genitourinary system) + +AnnotationAssertion(Annotation( "VHOG:0000286") "Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction.") +AnnotationAssertion( "AAO:0000624") +AnnotationAssertion( "BILA:0000122") +AnnotationAssertion( "BTO:0003091") +AnnotationAssertion( "EFO:0003864") +AnnotationAssertion( "EHDAA:1013") +AnnotationAssertion( "EMAPA:16367") +AnnotationAssertion( "EV:0100094") +AnnotationAssertion( "FMA:280610") +AnnotationAssertion( "GAID:362") +AnnotationAssertion( "MESH:D014566") +AnnotationAssertion( "NCIT:C12810") +AnnotationAssertion( "SCTID:278861008") +AnnotationAssertion( "VHOG:0000286") +AnnotationAssertion( "XAO:0000140") +AnnotationAssertion( "galen:GenitoUrinarySystem") +AnnotationAssertion(rdfs:label "genitourinary system") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (myocardial layer) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any of the layers of the myocardium. Example: compact layer, trabecular layer.") +AnnotationAssertion( "MA:0000080") +AnnotationAssertion(rdfs:label "myocardial layer") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (myocardium trabecular layer) + +AnnotationAssertion(Annotation( "ZFA:0005059") "The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA].") +AnnotationAssertion( "EFO:0003706") +AnnotationAssertion( "MA:0002866") +AnnotationAssertion( "TAO:0005059") +AnnotationAssertion( "ZFA:0005059") +AnnotationAssertion(rdfs:label "myocardium trabecular layer") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (trabecular layer of ventricle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A myocardium trabecular layer that is part of a cardiac ventricle.") +AnnotationAssertion( "FMA:83511") +AnnotationAssertion( "TAO:0005060") +AnnotationAssertion( "ZFA:0005060") +AnnotationAssertion(rdfs:label "trabecular layer of ventricle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (optic vesicle) +AnnotationAssertion(Annotation( "GO:0003404") Annotation( "Wikipedia:Optic_vesicles") "The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA].") +AnnotationAssertion( "AAO:0011039") +AnnotationAssertion( "EHDAA2:0001320") +AnnotationAssertion( "EMAPA:16540") +AnnotationAssertion( "FMA:293357") +AnnotationAssertion( "NCIT:C34236") +AnnotationAssertion( "SCTID:362864008") +AnnotationAssertion( "TAO:0000050") +AnnotationAssertion( "VHOG:0000165") +AnnotationAssertion( "Wikipedia:Optic_vesicles") +AnnotationAssertion( "XAO:0000228") +AnnotationAssertion( "ZFA:0000050") +AnnotationAssertion(rdfs:comment "Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 \"Developmental Biology\"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288]") AnnotationAssertion(rdfs:label "optic vesicle") SubClassOf( ) SubClassOf( ) @@ -34793,6 +53317,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (salivatory nucleus) +AnnotationAssertion(Annotation( "GO:0021751") "Missing definition for term UBERON:0004133. Please replace it using linked reference.") AnnotationAssertion(rdfs:label "salivatory nucleus") SubClassOf( ) SubClassOf( ) @@ -34800,12 +53325,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiogenic plate) +AnnotationAssertion(Annotation( "GO:0003142") "The first recognizable structure derived from the heart field.") +AnnotationAssertion( "EHDAA2:0000215") +AnnotationAssertion( "EMAPA:16106") +AnnotationAssertion( "VHOG:0000975") AnnotationAssertion(rdfs:label "cardiogenic plate") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (primary heart field) +AnnotationAssertion(Annotation( "GO:0003138") Annotation( "GOC:mtg_heart") Annotation( "GOC:rl") "A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.") +AnnotationAssertion( "XAO:0004185") AnnotationAssertion(rdfs:label "primary heart field") SubClassOf( ) SubClassOf( ) @@ -34816,6 +53347,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart tube) +AnnotationAssertion(Annotation( "GO:0003143") Annotation( "GOC:mtg_heart") "An epithelial tube that will give rise to the mature heart.") +AnnotationAssertion( "AAO:0010411") +AnnotationAssertion( "EFO:0003526") +AnnotationAssertion( "EMAPA:32685") +AnnotationAssertion( "NCIT:C34161") +AnnotationAssertion( "TAO:0000360") +AnnotationAssertion( "XAO:0000337") +AnnotationAssertion( "ZFA:0000360") AnnotationAssertion(rdfs:label "heart tube") SubClassOf( ) SubClassOf( ) @@ -34824,6 +53363,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow tract septum) +AnnotationAssertion(Annotation( "GO:0003148") "The outflow tract septum is a partition in the outflow tract.") +AnnotationAssertion( "XAO:0004141") AnnotationAssertion(rdfs:label "outflow tract septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34831,6 +53372,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow tract) +AnnotationAssertion(Annotation( "GO:0003151") "The outflow tract is the portion of the heart through which blood flows into the arteries.") +AnnotationAssertion( "EHDAA2:0001351") +AnnotationAssertion( "EHDAA:464") +AnnotationAssertion( "EHDAA:798") +AnnotationAssertion( "EMAPA:16346") +AnnotationAssertion( "MA:0000100") +AnnotationAssertion( "VHOG:0000670") +AnnotationAssertion( "XAO:0004139") AnnotationAssertion(rdfs:label "outflow tract") SubClassOf( ) SubClassOf( ) @@ -34841,6 +53390,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (His-Purkinje system) +AnnotationAssertion(Annotation( "GO:0003164") Annotation( "https://github.com/geneontology/go-ontology/issues/12451") "The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.") AnnotationAssertion(rdfs:label "His-Purkinje system") SubClassOf( ) SubClassOf( ) @@ -34849,6 +53399,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac vein) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Vein of heart that drains the myocardium.") +AnnotationAssertion( "EHDAA2:0004507") +AnnotationAssertion( "FMA:12846") +AnnotationAssertion( "NCIT:C12878") +AnnotationAssertion( "NCIT:C12882") +AnnotationAssertion( "SCTID:277726009") +AnnotationAssertion( "Wikipedia:Coronary_circulation") +AnnotationAssertion( "ZFA:0005814") +AnnotationAssertion( "galen:CoronaryVein") AnnotationAssertion(rdfs:label "cardiac vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34858,6 +53417,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac chamber) +AnnotationAssertion(Annotation( "GO:0003205") "A cardiac chamber surrounds an enclosed cavity within the heart.") +AnnotationAssertion( "FMA:7095") +AnnotationAssertion( "SCTID:276456008") +AnnotationAssertion(rdfs:comment "generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus") AnnotationAssertion(rdfs:label "cardiac chamber") SubClassOf( ) SubClassOf( ) @@ -34865,6 +53428,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (proepicardium) +AnnotationAssertion(Annotation( "GO:0003342") Annotation( "http://en.wiktionary.org/wiki/proepicardium") "An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium.") +AnnotationAssertion( "EMAPA:36025") +AnnotationAssertion( "ZFA:0005808") AnnotationAssertion(rdfs:label "proepicardium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -34872,6 +53438,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (septum transversum) +AnnotationAssertion(Annotation( "VHOG:0000019") Annotation( "Wikipedia:Septum_transversum") "A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG].") +AnnotationAssertion( "EHDAA2:0001829") +AnnotationAssertion( "EHDAA:736") +AnnotationAssertion( "EMAPA:16318") +AnnotationAssertion( "FMA:295593") +AnnotationAssertion( "NCIT:C34296") +AnnotationAssertion( "SCTID:308819008") +AnnotationAssertion( "VHOG:0000019") +AnnotationAssertion( "Wikipedia:Septum_transversum") AnnotationAssertion(rdfs:label "septum transversum") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -34879,17 +53454,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (internal genitalia) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0035260") "The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.") +AnnotationAssertion( "FMA:45652") +AnnotationAssertion(rdfs:comment "TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547") AnnotationAssertion(rdfs:label "internal genitalia") SubClassOf( ) # Class: (external genitalia) +AnnotationAssertion(Annotation( "GO:0035261") "The external genitalia are the outer sex organs, such as the penis or vulva in mammals.") +AnnotationAssertion( "FMA:45643") +AnnotationAssertion( "SCTID:362207005") +AnnotationAssertion(rdfs:comment "TODO: make a subdivision of reproductive system. Relabel. See https://github.com/obophenotype/uberon/issues/547") AnnotationAssertion(rdfs:label "external genitalia") SubClassOf( ) # Class: (hemopoietic organ) +AnnotationAssertion(Annotation( "GOC:Obol") "Organ that is part of the hematopoietic system.") +AnnotationAssertion( "BTO:0004605") +AnnotationAssertion( "FMA:7143") +AnnotationAssertion( "MA:0000747") +AnnotationAssertion( "SCTID:361338006") AnnotationAssertion(rdfs:label "hemopoietic organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34898,6 +53484,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aorta smooth muscle tissue) +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0009865") "The nonstriated, involuntary muscle tissue located in the wall of the aorta.") +AnnotationAssertion( "BTO:0001685") +AnnotationAssertion( "CALOHA:TS-0048") +AnnotationAssertion( "EFO:0002775") +AnnotationAssertion( "EMAPA:35135") +AnnotationAssertion( "MA:0000702") +AnnotationAssertion( "NCIT:C49191") AnnotationAssertion(rdfs:label "aorta smooth muscle tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34906,6 +53499,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endodermal part of digestive tract) +AnnotationAssertion(Annotation( "GO:0061031") "A portions of the gut that is derived from endoderm.") +AnnotationAssertion( "EMAPA:32930") AnnotationAssertion(rdfs:label "endodermal part of digestive tract") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34913,13 +53508,45 @@ SubClassOf( (back nerve) +AnnotationAssertion(Annotation( "OBOL:automatic") "A nerve that is part of a back [Automatically generated definition].") +AnnotationAssertion( "MA:0000497") AnnotationAssertion(rdfs:label "back nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (large intestine smooth muscle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35469") +AnnotationAssertion( "MA:0001547") +AnnotationAssertion(rdfs:label "large intestine smooth muscle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (intestine smooth muscle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition].") +AnnotationAssertion( "BTO:0000643") +AnnotationAssertion( "EMAPA:35441") +AnnotationAssertion( "EMAPA:35443") +AnnotationAssertion( "MA:0001539") +AnnotationAssertion( "NCIT:C49243") +AnnotationAssertion(rdfs:label "intestine smooth muscle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (stomach smooth muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition].") +AnnotationAssertion( "BTO:0001818") +AnnotationAssertion( "EMAPA:35823") +AnnotationAssertion( "MA:0001627") AnnotationAssertion(rdfs:label "stomach smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34927,6 +53554,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system smooth muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "BTO:0001660") +AnnotationAssertion( "EMAPA:35734") +AnnotationAssertion( "MA:0001830") AnnotationAssertion(rdfs:label "respiratory system smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34934,13 +53565,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gastrointestinal system smooth muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35117") +AnnotationAssertion( "MA:0001523") AnnotationAssertion(rdfs:label "gastrointestinal system smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (anal region smooth muscle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition].") +AnnotationAssertion( "MA:0001532") +AnnotationAssertion(rdfs:label "anal region smooth muscle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (lower respiratory tract smooth muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35520") +AnnotationAssertion( "MA:0002410") AnnotationAssertion(rdfs:label "lower respiratory tract smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34949,6 +53595,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (iris smooth muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a iris [Automatically generated definition].") +AnnotationAssertion( "BTO:0000655") +AnnotationAssertion( "EMAPA:35448") +AnnotationAssertion( "FMA:312338") +AnnotationAssertion( "MA:0001270") AnnotationAssertion(rdfs:label "iris smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34956,6 +53607,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (arteriole smooth muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36287") +AnnotationAssertion( "FMA:312251") +AnnotationAssertion( "MA:0000706") AnnotationAssertion(rdfs:label "arteriole smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34964,15 +53619,61 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (blood vessel smooth muscle) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Vascular_smooth_muscle") "Smooth muscle found within, and composing the majority of the wall of blood vessels.") +AnnotationAssertion( "BTO:0001431") +AnnotationAssertion( "CALOHA:TS-1107") +AnnotationAssertion( "EMAPA:35177") +AnnotationAssertion( "MA:0000710") +AnnotationAssertion( "MESH:D009131") +AnnotationAssertion( "NCIT:C33853") +AnnotationAssertion( "TAO:0005321") +AnnotationAssertion( "Wikipedia:Vascular_smooth_muscle") +AnnotationAssertion( "ZFA:0005321") AnnotationAssertion(rdfs:label "blood vessel smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (spleen smooth muscle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35807") +AnnotationAssertion( "MA:0000757") +AnnotationAssertion(rdfs:label "spleen smooth muscle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (small intestine smooth muscle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35783") +AnnotationAssertion( "MA:0001559") +AnnotationAssertion(rdfs:label "small intestine smooth muscle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (gallbladder smooth muscle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35373") +AnnotationAssertion( "MA:0001635") +AnnotationAssertion( "NCIT:C49483") +AnnotationAssertion(rdfs:label "gallbladder smooth muscle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (bronchus smooth muscle) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition].") +AnnotationAssertion( "BTO:0004401") +AnnotationAssertion( "EMAPA:35195") +AnnotationAssertion( "MA:0001840") +AnnotationAssertion( "NCIT:C49213") AnnotationAssertion(rdfs:label "bronchus smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34981,6 +53682,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow tract smooth muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition].") +AnnotationAssertion( "MA:0000492") AnnotationAssertion(rdfs:label "outflow tract smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34988,6 +53691,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bone of dorsum) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A bone that is part of the dorsal region of an animal.") +AnnotationAssertion( "MA:0000494") AnnotationAssertion(rdfs:label "bone of dorsum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -34995,6 +53700,11 @@ SubClassOf( (skin muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a skin of body [Automatically generated definition].") +AnnotationAssertion( "EMAPA:18187") +AnnotationAssertion( "EMAPA:35776") +AnnotationAssertion( "MA:0002710") +AnnotationAssertion( "MA:0003139") AnnotationAssertion(rdfs:label "skin muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35003,6 +53713,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (back blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a back [Automatically generated definition].") +AnnotationAssertion( "MA:0000493") AnnotationAssertion(rdfs:label "back blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35010,6 +53722,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow tract myocardium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A myocardium that is part of a outflow tract [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0001358") +AnnotationAssertion( "EMAPA:35623") +AnnotationAssertion( "MA:0000489") +AnnotationAssertion( "VHOG:0000603") AnnotationAssertion(rdfs:label "outflow tract myocardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35017,6 +53734,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (back connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of connective tissue that is part of a back [Automatically generated definition].") +AnnotationAssertion( "MA:0000495") AnnotationAssertion(rdfs:label "back connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35024,6 +53743,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow tract pericardium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A pericardium that is part of a outflow tract [Automatically generated definition].") +AnnotationAssertion( "MA:0000491") AnnotationAssertion(rdfs:label "outflow tract pericardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35032,6 +53753,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (eye muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscle that is part of the eye region.") +AnnotationAssertion( "AAO:0000156") +AnnotationAssertion( "EMAPA:35335") +AnnotationAssertion( "MA:0000271") AnnotationAssertion(rdfs:label "eye muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35041,7 +53766,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skeleton) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "VSAO:0000026") "Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.") +AnnotationAssertion( "AEO:0000168") +AnnotationAssertion( "EHDAA2:0001843") +AnnotationAssertion( "EHDAA:5047") +AnnotationAssertion( "EMAPA:17213") +AnnotationAssertion( "FMA:23875") +AnnotationAssertion( "GAID:177") +AnnotationAssertion( "MA:0003006") +AnnotationAssertion( "MAT:0000032") +AnnotationAssertion( "MESH:D012863") +AnnotationAssertion( "MIAA:0000032") +AnnotationAssertion( "SCTID:361378004") +AnnotationAssertion( "VSAO:0000026") +AnnotationAssertion( "Wikipedia:Skeleton") +AnnotationAssertion( "XAO:0004053") +AnnotationAssertion( "galen:Skeleton") AnnotationAssertion(rdfs:label "skeleton") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -35050,6 +53790,16 @@ DisjointClasses( (dermomyotome) +AnnotationAssertion(Annotation( "AEO:0000214") "The bilaminar epithelium formed from the myotome and dermatome.") +AnnotationAssertion( "AAO:0010572") +AnnotationAssertion( "AEO:0000214") +AnnotationAssertion( "EHDAA2:0003259") +AnnotationAssertion( "EMAPA:31109") +AnnotationAssertion( "FMA:295654") +AnnotationAssertion( "NCIT:C34140") +AnnotationAssertion( "TAO:0001513") +AnnotationAssertion( "VHOG:0000676") +AnnotationAssertion( "ZFA:0001513") AnnotationAssertion(rdfs:label "dermomyotome") SubClassOf( ) SubClassOf( ) @@ -35058,12 +53808,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart rudiment) +AnnotationAssertion(Annotation( "GO:0003313") "A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.") +AnnotationAssertion( "TAO:0000115") +AnnotationAssertion( "ZFA:0000115") AnnotationAssertion(rdfs:label "heart rudiment") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cardiac skeleton) +AnnotationAssertion(Annotation( "GO:0003204") Annotation( "Wikipedia:Cardiac_skeleton") "Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart.") +AnnotationAssertion( "EMAPA:36645") +AnnotationAssertion( "FMA:9496") +AnnotationAssertion( "Wikipedia:Cardiac_skeleton") AnnotationAssertion(rdfs:label "cardiac skeleton") SubClassOf( ) SubClassOf( ) @@ -35073,6 +53830,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system blood vessel smooth muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001806") AnnotationAssertion(rdfs:label "respiratory system blood vessel smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35081,6 +53840,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trophectoderm) +AnnotationAssertion(Annotation( "MP:0005028") "Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition.") +AnnotationAssertion( "BTO:0001840") +AnnotationAssertion( "EHDAA2:0002091") +AnnotationAssertion( "EHDAA:56") +AnnotationAssertion( "EMAPA:16046") +AnnotationAssertion( "VHOG:0000979") AnnotationAssertion(rdfs:label "trophectoderm") SubClassOf( ) SubClassOf( ) @@ -35090,12 +53855,25 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (optic eminence) +AnnotationAssertion(Annotation( "MP:0006305") "The embryonic structure that gives rise to the corneal ectoderm.") +AnnotationAssertion( "EHDAA:938") +AnnotationAssertion( "EMAPA:16322") +AnnotationAssertion( "RETIRED_EHDAA2:0001308") +AnnotationAssertion( "VHOG:0001296") AnnotationAssertion(rdfs:label "optic eminence") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (apical ectodermal ridge) +AnnotationAssertion(Annotation( "MP:0001676") Annotation( "Wikipedia:Apical_ectodermal_ridge") "Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP].") +AnnotationAssertion( "AAO:0010760") +AnnotationAssertion( "EMAPA:32744") +AnnotationAssertion( "NCIT:C34109") +AnnotationAssertion( "TAO:0002146") +AnnotationAssertion( "Wikipedia:Apical_ectodermal_ridge") +AnnotationAssertion( "XAO:0004121") +AnnotationAssertion( "ZFA:0001702") AnnotationAssertion(rdfs:label "apical ectodermal ridge") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -35107,6 +53885,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (paired limb/fin bud) +AnnotationAssertion(Annotation( "ISBN:9780878932504") Annotation( "MP:0005650") Annotation( "https://orcid.org/0000-0002-6601-2165") "An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP].") +AnnotationAssertion( "VHOG:0001258") +AnnotationAssertion(rdfs:comment "Genes: In limb buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, whereas in S. canicula fin buds, consistent with reported data in other cartilaginous fishes, Shh is transcribed late in fin development[PMID:17187056]") AnnotationAssertion(rdfs:label "paired limb/fin bud") SubClassOf( ) SubClassOf( ) @@ -35116,11 +53897,39 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch 1) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries.") +AnnotationAssertion( "AAO:0010364") +AnnotationAssertion( "CALOHA:TS-2089") +AnnotationAssertion( "EHDAA2:0000006") +AnnotationAssertion( "EHDAA:573") +AnnotationAssertion( "EMAPA:16118") +AnnotationAssertion( "FMA:293019") +AnnotationAssertion( "MFMO:0000095") +AnnotationAssertion( "NCIT:C34175") +AnnotationAssertion( "SCTID:308767008") +AnnotationAssertion( "TAO:0001595") +AnnotationAssertion( "VHOG:0000296") +AnnotationAssertion( "Wikipedia:First_pharyngeal_arch") +AnnotationAssertion( "XAO:0000097") +AnnotationAssertion( "ZFA:0001612") AnnotationAssertion(rdfs:label "pharyngeal arch 1") SubClassOf( ) # Class: (pharyngeal arch artery) +AnnotationAssertion(Annotation( "MP:0002672") "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP].") +AnnotationAssertion( "AAO:0010414") +AnnotationAssertion( "EFO:0003695") +AnnotationAssertion( "EHDAA2:0000186") +AnnotationAssertion( "EHDAA:398") +AnnotationAssertion( "EHDAA:7327") +AnnotationAssertion( "EMAPA:16684") +AnnotationAssertion( "NCIT:C32123") +AnnotationAssertion( "TAO:0005004") +AnnotationAssertion( "VHOG:0000122") +AnnotationAssertion( "Wikipedia:Aortic_arches") +AnnotationAssertion( "XAO:0000341") +AnnotationAssertion( "ZFA:0005004") AnnotationAssertion(rdfs:label "pharyngeal arch artery") SubClassOf( ) SubClassOf( ) @@ -35133,12 +53942,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ectoplacental cone) +AnnotationAssertion(Annotation( "MP:0001717") Annotation( "PMID:19829370") "Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta.") +AnnotationAssertion( "BTO:0001715") +AnnotationAssertion( "EMAPA:16059") AnnotationAssertion(rdfs:label "ectoplacental cone") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vitelline blood vessel) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Blood vessel that is connected to the yolk sac.") +AnnotationAssertion( "EMAPA:36494") AnnotationAssertion(rdfs:label "vitelline blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35147,6 +53961,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (Descemet's membrane) +AnnotationAssertion(Annotation( "MP:0004285") Annotation( "https://github.com/obophenotype/uberon/issues/15") "A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP].") +AnnotationAssertion( "EMAPA:18804") +AnnotationAssertion( "FMA:58309") +AnnotationAssertion( "GAID:894") +AnnotationAssertion( "MA:0001246") +AnnotationAssertion( "MESH:D003886") +AnnotationAssertion( "NCIT:C32454") +AnnotationAssertion( "SCTID:281076002") +AnnotationAssertion( "TAO:0002157") +AnnotationAssertion( "Wikipedia:Descemet%27s_membrane") +AnnotationAssertion( "ZFA:0001686") +AnnotationAssertion(rdfs:comment "The strong, resistant, thin, noncellular fourth layer of the cornea, located between the endothelium (from which it is secreted) and the stroma. (Cline et al., Dictionary of Visual Science, 4th ed)") AnnotationAssertion(rdfs:label "Descemet's membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35159,6 +53985,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anterior limiting lamina of cornea) +AnnotationAssertion(Annotation( "ncithesaurus:Bowman_s_Membrane") "A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane.") +AnnotationAssertion( "FMA:58273") +AnnotationAssertion( "MA:0001240") +AnnotationAssertion( "NCIT:C32226") +AnnotationAssertion( "SCTID:281075003") +AnnotationAssertion( "TAO:0002155") +AnnotationAssertion( "Wikipedia:Bowman%27s_membrane") +AnnotationAssertion( "ZFA:0001684") AnnotationAssertion(rdfs:label "anterior limiting lamina of cornea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35168,6 +54002,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vitelline vasculature) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Vascular network that is connected to the yolk sac.") +AnnotationAssertion( "Wikipedia:Vitelline_circulation") AnnotationAssertion(rdfs:label "vitelline vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35175,14 +54011,30 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bone of free limb or fin) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of an appendage [Automatically generated definition].") AnnotationAssertion(rdfs:label "bone of free limb or fin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (trunk or cervical vertebra) + +AnnotationAssertion(Annotation( "UBERONREF:0000006") "A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra.") +AnnotationAssertion( "MA:0002869") +AnnotationAssertion( "XAO:0003077") +AnnotationAssertion(rdfs:label "trunk or cervical vertebra") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +EquivalentClasses( ObjectUnionOf( )) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (neurula embryo) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An embryo at the neurula stage.") +AnnotationAssertion( "BILA:0000061") +AnnotationAssertion( "BTO:0001766") +AnnotationAssertion( "NCIT:C34229") AnnotationAssertion(rdfs:label "neurula embryo") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35191,6 +54043,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (entire sense organ system) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Sum of all sensory systems in an organism.") +AnnotationAssertion( "FMA:78499") AnnotationAssertion(rdfs:label "entire sense organ system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -35199,6 +54053,10 @@ DisjointClasses( (skeletal musculature of head) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of skeletal muscles that is part of a head [Automatically generated definition].") +AnnotationAssertion( "EMAPA:18171") +AnnotationAssertion( "FMA:71287") +AnnotationAssertion(rdfs:comment "This class is restricted to skeletal muscles that attach to the cranial skeleton. This seems to be consistent with FMA and EMAPA usage. Note that by definition this excludes invertebrate head musculature. It corresponds to the individual muscle organ term UBERON:0002376") AnnotationAssertion(rdfs:label "skeletal musculature of head") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35209,6 +54067,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (musculature of thorax) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of muscles that is part of a thorax [Automatically generated definition].") +AnnotationAssertion( "BTO:0000508") +AnnotationAssertion( "FMA:71293") AnnotationAssertion(rdfs:label "musculature of thorax") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35216,13 +54077,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (musculature of neck) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of muscles that is part of a neck [Automatically generated definition].") +AnnotationAssertion( "AAO:0000091") +AnnotationAssertion( "EMAPA:36050") +AnnotationAssertion( "FMA:71290") +AnnotationAssertion( "MESH:D009334") AnnotationAssertion(rdfs:label "musculature of neck") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (set of muscles of vertebral column) + +AnnotationAssertion( "FMA:33061") +AnnotationAssertion(rdfs:label "set of muscles of vertebral column") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (musculature of back) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of muscles that is part of a back [Automatically generated definition].") +AnnotationAssertion( "FMA:71291") AnnotationAssertion(rdfs:label "musculature of back") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35230,6 +54106,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (musculature of pectoral girdle) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles.") +AnnotationAssertion( "AAO:0000423") +AnnotationAssertion( "FMA:33519") AnnotationAssertion(rdfs:label "musculature of pectoral girdle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35237,6 +54116,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (musculature of face) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of muscles that is part of a face.") +AnnotationAssertion( "FMA:71288") AnnotationAssertion(rdfs:label "musculature of face") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35244,6 +54125,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (musculature of trunk) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of muscles that is part of a trunk [Automatically generated definition].") +AnnotationAssertion( "AAO:0011572") +AnnotationAssertion( "EFO:0003531") +AnnotationAssertion( "FMA:50187") AnnotationAssertion(rdfs:label "musculature of trunk") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35251,6 +54136,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac muscle tissue of atrium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition].") +AnnotationAssertion( "FMA:7283") AnnotationAssertion(rdfs:label "cardiac muscle tissue of atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35258,6 +54145,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac muscle tissue of interatrial septum) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition].") +AnnotationAssertion( "FMA:84083") AnnotationAssertion(rdfs:label "cardiac muscle tissue of interatrial septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35265,6 +54154,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac muscle tissue of cardiac septum) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition].") +AnnotationAssertion( "FMA:226279") AnnotationAssertion(rdfs:label "cardiac muscle tissue of cardiac septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35272,6 +54163,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac muscle tissue of myocardium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition].") +AnnotationAssertion( "FMA:261726") +AnnotationAssertion( "MA:0002441") AnnotationAssertion(rdfs:label "cardiac muscle tissue of myocardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35279,6 +54173,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skeletal muscle tissue of diaphragm) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition].") +AnnotationAssertion( "FMA:261898") AnnotationAssertion(rdfs:label "skeletal muscle tissue of diaphragm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35287,7 +54183,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (smooth muscle tissue of bronchiole) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition].") +AnnotationAssertion( "FMA:261045") AnnotationAssertion(rdfs:label "smooth muscle tissue of bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35295,7 +54192,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (smooth muscle tissue of terminal bronchiole) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition].") +AnnotationAssertion( "FMA:261051") AnnotationAssertion(rdfs:label "smooth muscle tissue of terminal bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35304,15 +54202,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (smooth muscle tissue of respiratory bronchiole) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition].") +AnnotationAssertion( "FMA:261055") AnnotationAssertion(rdfs:label "smooth muscle tissue of respiratory bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (muscle of vertebral column) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A muscle that is attached to a vertebra of the vertebral column.") +AnnotationAssertion( "FMA:22594") +AnnotationAssertion(rdfs:label "muscle of vertebral column") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vasculature of muscle organ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vasculature that is part of a muscle organ [Automatically generated definition].") +AnnotationAssertion( "FMA:87123") AnnotationAssertion(rdfs:label "vasculature of muscle organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35320,14 +54230,58 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vasculature of musculoskeletal system) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vasculature that is part of a musculoskeletal system [Automatically generated definition].") +AnnotationAssertion( "FMA:239607") AnnotationAssertion(rdfs:label "vasculature of musculoskeletal system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (cardiac muscle tissue of trabecula carnea of right ventricle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition].") +AnnotationAssertion( "FMA:84429") +AnnotationAssertion(rdfs:label "cardiac muscle tissue of trabecula carnea of right ventricle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (cardiac muscle tissue of trabecula carnea of left ventricle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition].") +AnnotationAssertion( "FMA:84430") +AnnotationAssertion(rdfs:label "cardiac muscle tissue of trabecula carnea of left ventricle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (cardiovascular system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "BTO:0000088") "Anatomical system that has as its parts the heart and blood vessels.") +AnnotationAssertion( "AAO:0011001") +AnnotationAssertion( "BILA:0000016") +AnnotationAssertion( "BTO:0000088") +AnnotationAssertion( "CALOHA:TS-1297") +AnnotationAssertion( "EFO:0000791") +AnnotationAssertion( "EHDAA:394") +AnnotationAssertion( "EMAPA:16104") +AnnotationAssertion( "EV:0100017") +AnnotationAssertion( "FMA:7161") +AnnotationAssertion( "GAID:467") +AnnotationAssertion( "MA:0000010") +AnnotationAssertion( "MAT:0000016") +AnnotationAssertion( "MESH:D002319") +AnnotationAssertion( "MIAA:0000016") +AnnotationAssertion( "NCIT:C12686") +AnnotationAssertion( "SCTID:278198007") +AnnotationAssertion( "TAO:0000010") +AnnotationAssertion( "VHOG:0000302") +AnnotationAssertion( "WikipediaCategory:Cardiovascular_system") +AnnotationAssertion( "XAO:0000100") +AnnotationAssertion( "XAO:0001010") +AnnotationAssertion( "ZFA:0000010") AnnotationAssertion(rdfs:label "cardiovascular system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35337,7 +54291,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (blood vasculature) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A vascular network consisting of blood vessels.") +AnnotationAssertion( "TAO:0001079") +AnnotationAssertion( "ZFA:0001079") AnnotationAssertion(rdfs:label "blood vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35345,6 +54301,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left eye) +AnnotationAssertion(Annotation( "OBOL:automatic") "An eye that is part of a left side of organism [Automatically generated definition].") +AnnotationAssertion( "FMA:12515") +AnnotationAssertion( "MA:0002949") +AnnotationAssertion( "NCIT:C119334") +AnnotationAssertion( "SCTID:362503005") AnnotationAssertion(rdfs:label "left eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35353,6 +54314,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right eye) +AnnotationAssertion(Annotation( "OBOL:automatic") "An eye that is part of a right side of organism [Automatically generated definition].") +AnnotationAssertion( "FMA:12514") +AnnotationAssertion( "MA:0002950") +AnnotationAssertion( "NCIT:C119333") +AnnotationAssertion( "SCTID:362502000") AnnotationAssertion(rdfs:label "right eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35361,20 +54327,33 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (systemic arterial system) +AnnotationAssertion(Annotation( "Wikipedia:Systemic_circulation#Arteries") Annotation( "http://orcid.org/0000-0002-6601-2165") "The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart.") +AnnotationAssertion( "FMA:45623") +AnnotationAssertion( "Wikipedia:Systemic_circulation#Arteries") AnnotationAssertion(rdfs:label "systemic arterial system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (arterial system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "The part of the cardiovascular system consisting of all arteries.") +AnnotationAssertion( "BTO:0004690") +AnnotationAssertion( "EHDAA2:0000143") +AnnotationAssertion( "EHDAA:396") +AnnotationAssertion( "EMAPA:16201") +AnnotationAssertion( "EMAPA:16371") +AnnotationAssertion( "MA:0002719") +AnnotationAssertion( "SCTID:362030008") +AnnotationAssertion( "VHOG:0000273") AnnotationAssertion(rdfs:label "arterial system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (systemic artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Artery#Systemic_arteries") Annotation( "http://orcid.org/0000-0002-6601-2165") "An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart.") +AnnotationAssertion( "FMA:66464") +AnnotationAssertion( "Wikipedia:Artery#Systemic_arteries") AnnotationAssertion(rdfs:label "systemic artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35382,27 +54361,74 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (systemic venous system) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Systemic_venous_system") "The part of the venous system that drains the general body tissues[Kardong].") +AnnotationAssertion( "FMA:45626") +AnnotationAssertion( "Wikipedia:Systemic_venous_system") AnnotationAssertion(rdfs:label "systemic venous system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (venous system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions.") +AnnotationAssertion( "BTO:0004692") +AnnotationAssertion( "EHDAA2:0002171") +AnnotationAssertion( "EHDAA:486") +AnnotationAssertion( "EMAPA:16240") +AnnotationAssertion( "MA:0002720") +AnnotationAssertion( "NCIT:C33858") +AnnotationAssertion( "SCTID:362060003") +AnnotationAssertion( "VHOG:0000277") AnnotationAssertion(rdfs:label "venous system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (sphincter muscle) + +AnnotationAssertion(Annotation( "Wikipedia:Sphincter") "A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.") +AnnotationAssertion( "FMA:75004") +AnnotationAssertion( "NCIT:C28381") +AnnotationAssertion( "Wikipedia:Sphincter") +AnnotationAssertion(rdfs:label "sphincter muscle") +SubClassOf( ) + # Class: (blood vessel endothelium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart.") +AnnotationAssertion( "BTO:0000766") +AnnotationAssertion( "CALOHA:TS-2155") +AnnotationAssertion( "EMAPA:35176") +AnnotationAssertion( "MA:0000709") +AnnotationAssertion( "NCIT:C53395") +AnnotationAssertion( "TAO:0005257") +AnnotationAssertion( "ZFA:0005257") AnnotationAssertion(rdfs:label "blood vessel endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (liver lobule) + +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0008987") "The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein.") +AnnotationAssertion( "EMAPA:35499") +AnnotationAssertion( "FMA:14471") +AnnotationAssertion( "MA:0002494") +AnnotationAssertion( "NCIT:C32732") +AnnotationAssertion( "SCTID:362194004") +AnnotationAssertion( "Wikipedia:Lobules_of_liver") +AnnotationAssertion(rdfs:label "liver lobule") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (aorta wall) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An anatomical wall that is part of an aorta, enclosing the luminal space.") +AnnotationAssertion( "EMAPA:35139") +AnnotationAssertion( "FMA:14156") +AnnotationAssertion( "MA:0002901") AnnotationAssertion(rdfs:label "aorta wall") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35411,6 +54437,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aorta tunica adventitia) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0009871") "The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers.") +AnnotationAssertion( "EMAPA:35136") +AnnotationAssertion( "FMA:14283") +AnnotationAssertion( "MA:0002902") +AnnotationAssertion( "SCTID:24996002") AnnotationAssertion(rdfs:label "aorta tunica adventitia") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35419,6 +54450,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (interventricular septum membranous part) +AnnotationAssertion(Annotation( "MP:0008823") "The membranous portion of the wall between the two lower chambers of the heart.") +AnnotationAssertion( "EHDAA2:0004596") +AnnotationAssertion( "EMAPA:18246") +AnnotationAssertion( "FMA:7135") +AnnotationAssertion( "MA:0002939") +AnnotationAssertion( "SCTID:278228007") +AnnotationAssertion( "VHOG:0000927") AnnotationAssertion(rdfs:label "interventricular septum membranous part") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35430,6 +54468,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (interventricular septum muscular part) +AnnotationAssertion(Annotation( "Wikipedia:Interventricular_septum#Portions") Annotation( "http://orcid.org/0000-0002-6601-2165") "The muscular portion of the wall between the two lower chambers of the heart.") +AnnotationAssertion( "EHDAA2:0000885") +AnnotationAssertion( "EHDAA:2607") +AnnotationAssertion( "EMAPA:18247") +AnnotationAssertion( "FMA:7134") +AnnotationAssertion( "MA:0002940") +AnnotationAssertion( "RETIRED_EHDAA2:0000888") AnnotationAssertion(rdfs:label "interventricular septum muscular part") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35438,6 +54483,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (raphe nuclei) +AnnotationAssertion(Annotation( "NLXANAT:20090205") Annotation( "https://sourceforge.net/tracker/?func=detail&aid=3248146&group_id=36855&atid=440764") "The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane.") +AnnotationAssertion( "BAMS:RA") +AnnotationAssertion( "EMAPA:35721") +AnnotationAssertion( "FMA:84017") +AnnotationAssertion( "MA:0003147") +AnnotationAssertion( "MESH:D011903") +AnnotationAssertion( "NCIT:C97335") +AnnotationAssertion( "NLXANAT:20090205") +AnnotationAssertion( "TAO:0001429") +AnnotationAssertion( "Wikipedia:Raphe_nuclei") +AnnotationAssertion( "ZFA:0001429") +AnnotationAssertion( "neuronames:2495") +AnnotationAssertion(rdfs:comment "we treat NR obscurus, NR magnus etc as parts of the raphe nuclei. This is consistent with treatment in FMA, where the class is 'set of raphe nuclei'") AnnotationAssertion(rdfs:label "raphe nuclei") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -35445,13 +54503,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (costo-cervical trunk) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Costocervical_trunk") "The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted].") +AnnotationAssertion( "FMA:10636") +AnnotationAssertion( "MA:0001939") +AnnotationAssertion( "SCTID:244225009") +AnnotationAssertion( "Wikipedia:Costocervical_trunk") AnnotationAssertion(rdfs:label "costo-cervical trunk") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (arterial system smooth muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36503") +AnnotationAssertion( "MA:0000704") AnnotationAssertion(rdfs:label "arterial system smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35459,6 +54524,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (venous system smooth muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36613") +AnnotationAssertion( "MA:0000715") AnnotationAssertion(rdfs:label "venous system smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35467,6 +54535,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vena cava endothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of a vena cava [Automatically generated definition].") +AnnotationAssertion( "MA:0000713") +AnnotationAssertion( "NCIT:C49318") AnnotationAssertion(rdfs:label "vena cava endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35474,6 +54545,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow tract endothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of a outflow tract [Automatically generated definition].") +AnnotationAssertion( "MA:0000490") +AnnotationAssertion( "VHOG:0001524") AnnotationAssertion(rdfs:label "outflow tract endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35481,6 +54555,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (arterial system endothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of an arterial system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35145") +AnnotationAssertion( "MA:0000703") +AnnotationAssertion( "NCIT:C49329") AnnotationAssertion(rdfs:label "arterial system endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35488,6 +54566,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (venous system endothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of a venous system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35907") +AnnotationAssertion( "MA:0000714") +AnnotationAssertion( "NCIT:C49320") AnnotationAssertion(rdfs:label "venous system endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35495,6 +54577,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system blood vessel endothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel endothelium that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35732") +AnnotationAssertion( "MA:0001805") AnnotationAssertion(rdfs:label "respiratory system blood vessel endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35503,12 +54588,23 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bulbus cordis) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0010568") "A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches.") +AnnotationAssertion( "EHDAA2:0000197") +AnnotationAssertion( "EHDAA:438") +AnnotationAssertion( "EHDAA:768") +AnnotationAssertion( "EMAPA:16333") +AnnotationAssertion( "FMA:70300") +AnnotationAssertion( "NCIT:C34114") +AnnotationAssertion( "SCTID:361525002") +AnnotationAssertion( "Wikipedia:Bulbus_cordis") AnnotationAssertion(rdfs:label "bulbus cordis") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (paired limb/fin) +AnnotationAssertion(Annotation( "UBERON:cjm") Annotation( "https://github.com/geneontology/go-ontology/issues/9029") "An appendage that is part of an appendage girdle complex.") +AnnotationAssertion( "VSAO:0000067") AnnotationAssertion(rdfs:label "paired limb/fin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35523,6 +54619,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage) +AnnotationAssertion(Annotation( "VSAO:0000150-modified") "Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues.") +AnnotationAssertion( "VHOG:0001753") +AnnotationAssertion( "VSAO:0000125") AnnotationAssertion(rdfs:label "pectoral appendage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35533,12 +54632,30 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (jugular vein) +AnnotationAssertion(Annotation( "Wikipedia:Jugular_vein") "The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava.") +AnnotationAssertion( "BTO:0001744") +AnnotationAssertion( "CALOHA:TS-0497") +AnnotationAssertion( "EMAPA:18638") +AnnotationAssertion( "GAID:536") +AnnotationAssertion( "MA:0002154") +AnnotationAssertion( "MESH:D007601") +AnnotationAssertion( "NCIT:C12738") +AnnotationAssertion( "SCTID:244403000") +AnnotationAssertion( "Wikipedia:Jugular_vein") AnnotationAssertion(rdfs:label "jugular vein") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (conceptus) +AnnotationAssertion(Annotation( "BTO:0003834") Annotation( "Wikipedia:Conceptus") "The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP].") +AnnotationAssertion( "AEO:0000194") +AnnotationAssertion( "BTO:0003834") +AnnotationAssertion( "EHDAA2:0000001") +AnnotationAssertion( "EHDAA2:0003235") +AnnotationAssertion( "EMAPA:36040") +AnnotationAssertion( "NCIT:C34131") +AnnotationAssertion( "Wikipedia:Conceptus") AnnotationAssertion(rdfs:label "conceptus") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -35549,6 +54666,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neuromere) +AnnotationAssertion(Annotation( "DOI:10.1016/j.tins.2013.06.004") Annotation( "https://github.com/obophenotype/uberon/issues/318") "A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres).") +AnnotationAssertion( "NLX:147842") +AnnotationAssertion( "TAO:0001328") +AnnotationAssertion( "Wikipedia:Neuromere") +AnnotationAssertion( "ZFA:0001328") AnnotationAssertion(rdfs:label "neuromere") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35557,6 +54679,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (segmental subdivision of nervous system) +AnnotationAssertion(Annotation( "FBbt:00005140") Annotation( "http://orcid.org/0000-0002-6601-2165") "Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres.") AnnotationAssertion(rdfs:label "segmental subdivision of nervous system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35564,6 +54687,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (segmental subdivision of hindbrain) +AnnotationAssertion(Annotation( "OBOL:automatic") "An organ subunit that is part of a hindbrain [Automatically generated definition].") +AnnotationAssertion( "FMA:61998") AnnotationAssertion(rdfs:label "segmental subdivision of hindbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35572,6 +54697,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gastrula) +AnnotationAssertion(Annotation( "Wikipedia:Gastrula") Annotation( "Wikipedia:Trilaminar_blastocyst") "Organism at the gastrula stage.") +AnnotationAssertion( "BILA:0000060") +AnnotationAssertion( "BTO:0001403") +AnnotationAssertion( "FMA:293108") +AnnotationAssertion( "GAID:1302") +AnnotationAssertion( "MESH:D005775") +AnnotationAssertion( "MIAA:0000179") +AnnotationAssertion( "NCIT:C34057") +AnnotationAssertion( "NCIT:C34058") +AnnotationAssertion( "Wikipedia:Gastrula") +AnnotationAssertion( "Wikipedia:Trilaminar_blastocyst") AnnotationAssertion(rdfs:label "gastrula") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35580,6 +54716,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skeletal tissue) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000015") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "https://github.com/obophenotype/uberon/issues/134") "A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].") +AnnotationAssertion( "MA:0003047") +AnnotationAssertion( "SCTID:309311006") +AnnotationAssertion( "VSAO:0000015") +AnnotationAssertion( "XAO:0004038") +AnnotationAssertion( "ZFA:0005619") +AnnotationAssertion(rdfs:comment "Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from") AnnotationAssertion(rdfs:label "skeletal tissue") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -35587,6 +54730,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dermal skeletal element) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/206") "Dermis-derived entity that is made of skeletal tissue.") AnnotationAssertion(rdfs:label "dermal skeletal element") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35594,8 +54738,33 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (gland of anal canal) + +AnnotationAssertion(Annotation( "OBOL:automatic") Annotation( "Wikipedia:Anal_gland") "A gland that is part of an anal canal [Automatically generated definition].") +AnnotationAssertion( "EMAPA:27221") +AnnotationAssertion( "EMAPA:27233") +AnnotationAssertion( "EMAPA:27543") +AnnotationAssertion( "FMA:15720") +AnnotationAssertion( "FMA:15724") +AnnotationAssertion( "NCIT:C32068") +AnnotationAssertion( "SCTID:245448005") +AnnotationAssertion( "Wikipedia:Anal_gland") +AnnotationAssertion(rdfs:label "gland of anal canal") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (cartilaginous neurocranium) +AnnotationAssertion(Annotation( "Wikipedia:Chondrocranium") "The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP].") +AnnotationAssertion( "AAO:0000094") +AnnotationAssertion( "EHDAA:6031") +AnnotationAssertion( "FMA:76621") +AnnotationAssertion( "NCIT:C34121") +AnnotationAssertion( "SCTID:155540009") +AnnotationAssertion( "Wikipedia:Chondrocranium") +AnnotationAssertion( "XAO:0003059") AnnotationAssertion(rdfs:label "cartilaginous neurocranium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -35604,6 +54773,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (intramembranous bone tissue) +AnnotationAssertion(Annotation( "GO:0001957") Annotation( "Wikipedia:Intramembranous_ossification") "Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].") +AnnotationAssertion( "MA:0002837") +AnnotationAssertion( "Wikipedia:Intramembranous_ossification") AnnotationAssertion(rdfs:label "intramembranous bone tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35613,13 +54785,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skeletal element) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.") +AnnotationAssertion( "AAO:0011129") +AnnotationAssertion( "TAO:0001890") +AnnotationAssertion( "VSAO:0000128") +AnnotationAssertion( "XAO:0004012") +AnnotationAssertion( "ZFA:0005494") +AnnotationAssertion( "galen:SkeletalStructure") AnnotationAssertion(rdfs:label "skeletal element") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cranial bone) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "UBERON:automatic") "A bone that is part of a cranium.") +AnnotationAssertion( "SCTID:181792001") AnnotationAssertion(rdfs:label "cranial bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35627,6 +54807,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bone of lower jaw) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular.") AnnotationAssertion(rdfs:label "bone of lower jaw") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35634,6 +54815,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (articular system) +AnnotationAssertion(Annotation( "VSAO:0000181") "Anatomical system that consists of all the joints of the body.") +AnnotationAssertion( "EMAPA:35150") +AnnotationAssertion( "FMA:23878") +AnnotationAssertion( "MA:0003007") +AnnotationAssertion( "SCTID:361827000") +AnnotationAssertion( "VSAO:0000181") AnnotationAssertion(rdfs:label "articular system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35645,6 +54832,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system submucosa) +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001822") AnnotationAssertion(rdfs:label "respiratory system submucosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35652,6 +54841,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system lamina propria) +AnnotationAssertion(Annotation( "OBOL:automatic") "A lamina propria that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001821") AnnotationAssertion(rdfs:label "respiratory system lamina propria") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35660,20 +54851,55 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gastrointestinal system lamina propria) +AnnotationAssertion(Annotation( "OBOL:automatic") "A lamina propria that is part of a gastrointestinal system.") +AnnotationAssertion( "MA:0001899") +AnnotationAssertion( "NCIT:C49299") AnnotationAssertion(rdfs:label "gastrointestinal system lamina propria") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (gallbladder lamina propria) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A lamina propria that is part of a gallbladder [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35371") +AnnotationAssertion( "FMA:278594") +AnnotationAssertion( "MA:0001633") +AnnotationAssertion( "NCIT:C49228") +AnnotationAssertion(rdfs:label "gallbladder lamina propria") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (gastrointestinal system serosa) +AnnotationAssertion(Annotation( "OBOL:automatic") "A serous membrane that is part of a digestive system [Automatically generated definition].") +AnnotationAssertion( "MA:0001522") AnnotationAssertion(rdfs:label "gastrointestinal system serosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (gallbladder serosa) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A serous membrane that is part of a gallbladder [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35372") +AnnotationAssertion( "FMA:14659") +AnnotationAssertion( "MA:0001634") +AnnotationAssertion( "SCTID:362197006") +AnnotationAssertion(rdfs:label "gallbladder serosa") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (heart ventricle wall) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical wall that is part of a cardiac ventricle [Automatically generated definition].") +AnnotationAssertion( "FMA:13884") +AnnotationAssertion( "MA:0002791") +AnnotationAssertion( "NCIT:C119295") AnnotationAssertion(rdfs:label "heart ventricle wall") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35681,6 +54907,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system mucosa) +AnnotationAssertion(Annotation( "MESH:A04.760") Annotation( "MGI:cwg") Annotation( "MP:0002277") "The mucous membrane lining the respiratory tract.") +AnnotationAssertion( "BTO:0000973") +AnnotationAssertion( "FMA:302092") +AnnotationAssertion( "GAID:304") +AnnotationAssertion( "MA:0001827") +AnnotationAssertion( "MESH:D020545") AnnotationAssertion(rdfs:label "respiratory system mucosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35688,6 +54920,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gastrointestinal system mucosa) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a gastrointestinal system.") +AnnotationAssertion( "BTO:0000546") +AnnotationAssertion( "BTO:0005568") +AnnotationAssertion( "EMAPA:36591") +AnnotationAssertion( "MA:0001521") +AnnotationAssertion( "SCTID:410433007") +AnnotationAssertion(rdfs:comment "The gut mucosa of amphioxus has insulin-secreting cells. http://www.ncbi.nlm.nih.gov/pubmed/16417468") AnnotationAssertion(rdfs:label "gastrointestinal system mucosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35698,15 +54937,63 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (skin mucous gland) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A mucous gland that is part of the skin.") +AnnotationAssertion( "EMAPA:35775") +AnnotationAssertion( "MA:0000148") +AnnotationAssertion(rdfs:label "skin mucous gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) + +# Class: (secretion of endocrine pancreas) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A secretion that is part of a endocrine pancreas [Automatically generated definition].") +AnnotationAssertion( "MA:0002517") +AnnotationAssertion( "NCIT:C33255") +AnnotationAssertion(rdfs:label "secretion of endocrine pancreas") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (secretion of exocrine pancreas) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A secretion that is part of a exocrine pancreas [Automatically generated definition].") +AnnotationAssertion( "MA:0002518") +AnnotationAssertion( "NCIT:C33256") +AnnotationAssertion(rdfs:label "secretion of exocrine pancreas") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (esophagus secretion) +AnnotationAssertion(Annotation( "OBOL:automatic") "A secretion that is part of a esophagus [Automatically generated definition].") +AnnotationAssertion( "FMA:79662") +AnnotationAssertion( "MA:0002514") +AnnotationAssertion( "NCIT:C52555") AnnotationAssertion(rdfs:label "esophagus secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreas secretion) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A secretion that is part of a pancreas [Automatically generated definition].") +AnnotationAssertion( "MA:0002516") +AnnotationAssertion( "NCIT:C13270") +AnnotationAssertion(rdfs:label "pancreas secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (blood vessel layer) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia.") +AnnotationAssertion( "EMAPA:36296") +AnnotationAssertion( "MA:0002854") AnnotationAssertion(rdfs:label "blood vessel layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35715,6 +55002,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory tract epithelium) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MGI:anna") Annotation( "MP:0010942") "The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi.") +AnnotationAssertion( "BTO:0000419") +AnnotationAssertion( "CALOHA:TS-0023") +AnnotationAssertion( "EMAPA:32827") +AnnotationAssertion( "MA:0001480") +AnnotationAssertion( "SCTID:321764001") AnnotationAssertion(rdfs:label "respiratory tract epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35725,6 +55018,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "CALOHA:TS-0023") +AnnotationAssertion( "EMAPA:32826") +AnnotationAssertion( "MA:0001823") AnnotationAssertion(rdfs:label "respiratory system epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35732,6 +55029,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gastrointestinal system epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a digestive system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:32683") +AnnotationAssertion( "MA:0001520") AnnotationAssertion(rdfs:label "gastrointestinal system epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35739,13 +55039,35 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lower respiratory tract epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a lower respiratory tract [Automatically generated definition].") +AnnotationAssertion( "MA:0001481") AnnotationAssertion(rdfs:label "lower respiratory tract epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (bile duct epithelium) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any epithelium that lines one of the bile ducts.") +AnnotationAssertion( "BTO:0000417") +AnnotationAssertion( "MA:0001629") +AnnotationAssertion( "NCIT:C43616") +AnnotationAssertion(rdfs:label "bile duct epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (pulmonary alveolus epithelium) +AnnotationAssertion(Annotation( "BTO:0003511") Annotation( "MP:0010898") "The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO].") +AnnotationAssertion( "BTO:0003511") +AnnotationAssertion( "EMAPA:35121") +AnnotationAssertion( "FMA:63915") +AnnotationAssertion( "MA:0001771") +AnnotationAssertion( "NCIT:C12867") AnnotationAssertion(rdfs:label "pulmonary alveolus epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35755,8 +55077,34 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (extrahepatic bile duct epithelium) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a extrahepatic bile duct [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0000742") +AnnotationAssertion( "EHDAA:3051") +AnnotationAssertion( "MA:0002661") +AnnotationAssertion( "NCIT:C43618") +AnnotationAssertion(rdfs:label "extrahepatic bile duct epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (intrahepatic bile duct epithelium) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a intrahepatic bile duct [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0000743") +AnnotationAssertion( "EHDAA:3053") +AnnotationAssertion( "MA:0002662") +AnnotationAssertion( "NCIT:C43617") +AnnotationAssertion(rdfs:label "intrahepatic bile duct epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (respiratory system skeletal muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001829") AnnotationAssertion(rdfs:label "respiratory system skeletal muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35764,21 +55112,47 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (esophagus skeletal muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36523") +AnnotationAssertion( "MA:0001572") +AnnotationAssertion(rdfs:comment "Most muscle tissue lining the digestive tract is smooth, but part of the externa of the esophagus is skeletal") AnnotationAssertion(rdfs:label "esophagus skeletal muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (anal region skeletal muscle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition].") +AnnotationAssertion( "MA:0001530") +AnnotationAssertion(rdfs:label "anal region skeletal muscle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (lip skeletal muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition].") +AnnotationAssertion( "MA:0001578") AnnotationAssertion(rdfs:label "lip skeletal muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepatic duct smooth muscle) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Smooth muscle tissue in all or part of a hepatic duct.") +AnnotationAssertion( "MA:0001640") +AnnotationAssertion(rdfs:label "hepatic duct smooth muscle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (respiratory system arterial endothelium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium of artery that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001801") AnnotationAssertion(rdfs:label "respiratory system arterial endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35787,7 +55161,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system venous endothelium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium of vein that is part of a respiratory system [Automatically generated definition].") +AnnotationAssertion( "MA:0001811") AnnotationAssertion(rdfs:label "respiratory system venous endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35796,6 +55171,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aorta endothelium) +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0009864") "The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall.") +AnnotationAssertion( "BTO:0000394") +AnnotationAssertion( "CALOHA:TS-0047") +AnnotationAssertion( "EFO:0002597") +AnnotationAssertion( "EMAPA:35134") +AnnotationAssertion( "MA:0000701") +AnnotationAssertion( "NCIT:C49190") AnnotationAssertion(rdfs:label "aorta endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35804,13 +55186,35 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiovascular system endothelium) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An endothelium that is part of the cardiovascular system.") +AnnotationAssertion( "BTO:0001853") +AnnotationAssertion( "EMAPA:35201") +AnnotationAssertion( "GAID:519") +AnnotationAssertion( "MA:0000717") +AnnotationAssertion( "MESH:D004730") +AnnotationAssertion( "NCIT:C13053") +AnnotationAssertion( "TAO:0002171") +AnnotationAssertion( "VHOG:0001217") +AnnotationAssertion( "XAO:0000356") +AnnotationAssertion( "ZFA:0001639") AnnotationAssertion(rdfs:label "cardiovascular system endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (gastrointestinal system mesentery) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesentery that is part of a digestive system [Automatically generated definition].") +AnnotationAssertion( "MA:0001900") +AnnotationAssertion(rdfs:label "gastrointestinal system mesentery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (skeletal muscle connective tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A connective tissue that surrounds a skeletal muscle tissue.") +AnnotationAssertion( "MA:0002868") AnnotationAssertion(rdfs:label "skeletal muscle connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35818,6 +55222,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (eye gland) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid.") +AnnotationAssertion( "EMAPA:35334") +AnnotationAssertion( "MA:0000267") +AnnotationAssertion(rdfs:comment "Examples: harderian gland, accessory lacrimal gland, gland of Moll, gland of Zeis, nictitating membrane glands") AnnotationAssertion(rdfs:label "eye gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35825,6 +55233,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right lung alveolus) +AnnotationAssertion(Annotation( "OBOL:automatic") "An alveolus that is part of a right lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35997") +AnnotationAssertion( "MA:0001786") +AnnotationAssertion( "NCIT:C49278") AnnotationAssertion(rdfs:label "right lung alveolus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35832,6 +55244,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left lung alveolus) +AnnotationAssertion(Annotation( "OBOL:automatic") "An alveolus that is part of a left lung [Automatically generated definition].") +AnnotationAssertion( "EMAPA:19182") +AnnotationAssertion( "MA:0001777") +AnnotationAssertion( "NCIT:C49251") AnnotationAssertion(rdfs:label "left lung alveolus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35839,21 +55255,50 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vasculature of retina) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vasculature that is part of a retina [Automatically generated definition].") +AnnotationAssertion( "FMA:76552") +AnnotationAssertion( "MESH:D012171") AnnotationAssertion(rdfs:label "vasculature of retina") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (orbital cavity) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye.") +AnnotationAssertion( "AAO:0000343") +AnnotationAssertion( "FMA:84961") +AnnotationAssertion( "SCTID:280541000") +AnnotationAssertion( "Wikipedia:Orbit_(anatomy)") +AnnotationAssertion( "ZFA:0005558") +AnnotationAssertion(rdfs:label "orbital cavity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (splanchnic layer of lateral plate mesoderm) +AnnotationAssertion(Annotation( "Wikipedia:Lateral_plate_mesoderm#Division_into_layers") "Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP].") +AnnotationAssertion( "AAO:0011102") +AnnotationAssertion( "BILA:0000044") +AnnotationAssertion( "FMA:295568") +AnnotationAssertion( "Wikipedia:Lateral_plate_mesoderm#Division_into_layers") +AnnotationAssertion( "XAO:0000276") AnnotationAssertion(rdfs:label "splanchnic layer of lateral plate mesoderm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (splanchnopleure) +AnnotationAssertion(Annotation( "Wikipedia:Splanchnopleure") "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP].") +AnnotationAssertion( "EHDAA2:0001903") +AnnotationAssertion( "EHDAA:383") +AnnotationAssertion( "EMAPA:16181") +AnnotationAssertion( "FMA:295564") +AnnotationAssertion( "NCIT:C34303") +AnnotationAssertion( "VHOG:0000558") +AnnotationAssertion( "Wikipedia:Splanchnopleure") AnnotationAssertion(rdfs:label "splanchnopleure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -35861,6 +55306,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (somatopleure) +AnnotationAssertion(Annotation( "Wikipedia:Somatopleure") "A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP].") +AnnotationAssertion( "EHDAA2:0001847") +AnnotationAssertion( "EHDAA:381") +AnnotationAssertion( "EMAPA:16180") +AnnotationAssertion( "FMA:295566") +AnnotationAssertion( "NCIT:C34301") +AnnotationAssertion( "VHOG:0000557") +AnnotationAssertion( "Wikipedia:Somatopleure") AnnotationAssertion(rdfs:label "somatopleure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -35868,6 +55321,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (chordamesoderm) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "The central region of trunk mesoderm. This tissue forms the notochord.") +AnnotationAssertion( "AAO:0000478") +AnnotationAssertion( "EFO:0003426") +AnnotationAssertion( "TAO:0000091") +AnnotationAssertion( "ZFA:0000091") AnnotationAssertion(rdfs:label "chordamesoderm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -35875,7 +55333,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung mesenchyme) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0060484") "The mass of tissue made up of mesenchymal cells in the lung.") +AnnotationAssertion( "EMAPA:32866") AnnotationAssertion(rdfs:label "lung mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35885,6 +55344,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (interalveolar septum) +AnnotationAssertion(Annotation( "LG:0012625") Annotation( "Wikipedia:Alveolar_septum") "A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung.") +AnnotationAssertion( "BTO:0003149") +AnnotationAssertion( "EMAPA:35433") +AnnotationAssertion( "MA:0000421") +AnnotationAssertion( "NCIT:C49473") +AnnotationAssertion( "Wikipedia:Alveolar_septum") AnnotationAssertion(rdfs:label "interalveolar septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35894,6 +55359,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (alveolar wall) +AnnotationAssertion(Annotation( "LG:0012626") Annotation( "MP:0010903") "A wall that contains the alveoli.") +AnnotationAssertion( "BTO:0002543") +AnnotationAssertion( "EMAPA:35120") +AnnotationAssertion( "FMA:14117") +AnnotationAssertion( "MA:0002568") +AnnotationAssertion( "NCIT:C13085") +AnnotationAssertion( "SCTID:361965008") AnnotationAssertion(rdfs:label "alveolar wall") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35903,6 +55375,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (alveolar smooth muscle) +AnnotationAssertion(Annotation( "LG:0012628") "Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus.") +AnnotationAssertion( "EMAPA:35122") +AnnotationAssertion( "MA:0002759") AnnotationAssertion(rdfs:label "alveolar smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35910,7 +55385,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neuron projection bundle connecting eye with brain) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila.") +AnnotationAssertion( "BTO:0000966") +AnnotationAssertion( "EV:0100351") +AnnotationAssertion( "TADS:0000232") +AnnotationAssertion(rdfs:comment "for the vertebrate-specific structure, see UBERON:0000941 (cranial nerve II)") AnnotationAssertion(rdfs:label "neuron projection bundle connecting eye with brain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35920,25 +55399,50 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (articulation) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts.") AnnotationAssertion(rdfs:label "articulation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (ectodermal part of digestive tract) +AnnotationAssertion(Annotation( "GO:0007439") "A portion of the gut that is derived from ectoderm.") AnnotationAssertion(rdfs:label "ectodermal part of digestive tract") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (lower digestive tract) + +AnnotationAssertion(Annotation( "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract") "The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition].") +AnnotationAssertion( "FMA:49179") +AnnotationAssertion( "NCIT:C33010") +AnnotationAssertion( "SCTID:279973004") +AnnotationAssertion( "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract") +AnnotationAssertion( "galen:LowerGastrointestinalTract") +AnnotationAssertion(rdfs:label "lower digestive tract") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (upper digestive tract) +AnnotationAssertion(Annotation( "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract") "The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum.") +AnnotationAssertion( "FMA:49177") +AnnotationAssertion( "NCIT:C33837") +AnnotationAssertion( "SCTID:181244000") +AnnotationAssertion( "Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract") +AnnotationAssertion( "galen:UpperGastrointestinalTract") AnnotationAssertion(rdfs:label "upper digestive tract") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (epithelium of gonad) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium surrounding a gonad.") +AnnotationAssertion( "EHDAA:4032") +AnnotationAssertion( "EHDAA:5931") +AnnotationAssertion( "NCIT:C32676") AnnotationAssertion(rdfs:label "epithelium of gonad") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35947,14 +55451,88 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelium of female gonad) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium surrounding an ovary.") +AnnotationAssertion( "BTO:0003661") AnnotationAssertion(rdfs:label "epithelium of female gonad") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (biliary bud) + +AnnotationAssertion( "EHDAA2:0000171") +AnnotationAssertion( "EMAPA:16561") +AnnotationAssertion( "EMAPA_RETIRED:16565") +AnnotationAssertion( "VHOG:0001351") +AnnotationAssertion(rdfs:label "biliary bud") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (hepatopancreatic ampulla) + +AnnotationAssertion(Annotation( "Wikipedia:Ampulla_of_Vater") "A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct.") +AnnotationAssertion( "CALOHA:TS-2348") +AnnotationAssertion( "FMA:15076") +AnnotationAssertion( "GAID:283") +AnnotationAssertion( "MESH:D014670") +AnnotationAssertion( "NCIT:C13011") +AnnotationAssertion( "SCTID:362200007") +AnnotationAssertion( "TAO:0005167") +AnnotationAssertion( "Wikipedia:Ampulla_of_Vater") +AnnotationAssertion( "ZFA:0005167") +AnnotationAssertion( "galen:AmpullaOfVater") +AnnotationAssertion(rdfs:label "hepatopancreatic ampulla") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (duodenal papilla) + +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/duodenal+papilla") "One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct.") +AnnotationAssertion( "EMAPA:18662") +AnnotationAssertion( "FMA:15953") +AnnotationAssertion( "MA:0003107") +AnnotationAssertion( "NCIT:C119578") +AnnotationAssertion( "SCTID:245389007") +AnnotationAssertion(rdfs:label "duodenal papilla") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (sphincter of hepatopancreatic ampulla) + +AnnotationAssertion(Annotation( "Wikipedia:Sphincter_of_ampulla") "Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP].") +AnnotationAssertion( "EMAPA:18663") +AnnotationAssertion( "FMA:15077") +AnnotationAssertion( "GAID:285") +AnnotationAssertion( "MESH:D009803") +AnnotationAssertion( "NCIT:C13065") +AnnotationAssertion( "SCTID:181271000") +AnnotationAssertion( "Wikipedia:Sphincter_of_ampulla") +AnnotationAssertion(rdfs:label "sphincter of hepatopancreatic ampulla") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (anal sphincter) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A sphincter muscle that is part of a anal region.") +AnnotationAssertion( "EMAPA:36052") +AnnotationAssertion(rdfs:label "anal sphincter") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (subdivision of digestive tract) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A proximal-distal subdivision of the digestive tract.") +AnnotationAssertion( "FMA:71131") AnnotationAssertion(rdfs:label "subdivision of digestive tract") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -35963,6 +55541,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (organ component layer) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A part of a wall of an organ that forms a layer.") +AnnotationAssertion( "FMA:82485") AnnotationAssertion(rdfs:label "organ component layer") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -35970,29 +55550,251 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (submucosa of pharynx) +AnnotationAssertion(Annotation( "BTO:0002113") "The tissue underlying the tunica mucosa of the pharynx.") +AnnotationAssertion( "BTO:0002113") +AnnotationAssertion( "FMA:75144") +AnnotationAssertion( "SCTID:19594009") AnnotationAssertion(rdfs:label "submucosa of pharynx") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (submucosa of cystic duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a cystic duct [Automatically generated definition].") +AnnotationAssertion( "FMA:18013") +AnnotationAssertion(rdfs:label "submucosa of cystic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of sigmoid colon) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a sigmoid colon [Automatically generated definition].") +AnnotationAssertion( "FMA:15027") +AnnotationAssertion(rdfs:label "submucosa of sigmoid colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of body of stomach) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a body of stomach [Automatically generated definition].") +AnnotationAssertion( "FMA:17059") +AnnotationAssertion(rdfs:label "submucosa of body of stomach") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of pyloric antrum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a pyloric antrum [Automatically generated definition].") +AnnotationAssertion( "FMA:17060") +AnnotationAssertion(rdfs:label "submucosa of pyloric antrum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of pylorus) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a pylorus [Automatically generated definition].") +AnnotationAssertion( "EMAPA:27201") +AnnotationAssertion( "FMA:17462") +AnnotationAssertion(rdfs:label "submucosa of pylorus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of biliary tree) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a biliary tree [Automatically generated definition].") +AnnotationAssertion( "FMA:18009") +AnnotationAssertion(rdfs:label "submucosa of biliary tree") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of common bile duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a common bile duct [Automatically generated definition].") +AnnotationAssertion( "FMA:18011") +AnnotationAssertion(rdfs:label "submucosa of common bile duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of common hepatic duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a common hepatic duct [Automatically generated definition].") +AnnotationAssertion( "FMA:18014") +AnnotationAssertion(rdfs:label "submucosa of common hepatic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of right hepatic duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a right hepatic duct [Automatically generated definition].") +AnnotationAssertion( "FMA:18015") +AnnotationAssertion(rdfs:label "submucosa of right hepatic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of left hepatic duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a left hepatic duct [Automatically generated definition].") +AnnotationAssertion( "FMA:18017") +AnnotationAssertion(rdfs:label "submucosa of left hepatic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (submucosa of bronchiole) +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a bronchiole [Automatically generated definition].") +AnnotationAssertion( "FMA:62775") AnnotationAssertion(rdfs:label "submucosa of bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mucosa of cystic duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a cystic duct [Automatically generated definition].") +AnnotationAssertion( "FMA:14690") +AnnotationAssertion(rdfs:label "mucosa of cystic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of sigmoid colon) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a sigmoid colon [Automatically generated definition].") +AnnotationAssertion( "FMA:15026") +AnnotationAssertion(rdfs:label "mucosa of sigmoid colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of body of stomach) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a body of stomach [Automatically generated definition].") +AnnotationAssertion( "FMA:17054") +AnnotationAssertion(rdfs:label "mucosa of body of stomach") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of pyloric antrum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a pyloric antrum [Automatically generated definition].") +AnnotationAssertion( "BTO:0004107") +AnnotationAssertion( "FMA:17055") +AnnotationAssertion(rdfs:label "mucosa of pyloric antrum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of pylorus) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a pylorus [Automatically generated definition].") +AnnotationAssertion( "BTO:0004110") +AnnotationAssertion( "EMAPA:27199") +AnnotationAssertion( "FMA:17461") +AnnotationAssertion(rdfs:label "mucosa of pylorus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of biliary tree) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a biliary tree [Automatically generated definition].") +AnnotationAssertion( "FMA:14695") +AnnotationAssertion(rdfs:label "mucosa of biliary tree") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of common bile duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a common bile duct [Automatically generated definition].") +AnnotationAssertion( "FMA:14688") +AnnotationAssertion(rdfs:label "mucosa of common bile duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of common hepatic duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a common hepatic duct [Automatically generated definition].") +AnnotationAssertion( "FMA:14691") +AnnotationAssertion(rdfs:label "mucosa of common hepatic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of right hepatic duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a right hepatic duct [Automatically generated definition].") +AnnotationAssertion( "FMA:14692") +AnnotationAssertion(rdfs:label "mucosa of right hepatic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of left hepatic duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a left hepatic duct [Automatically generated definition].") +AnnotationAssertion( "FMA:14693") +AnnotationAssertion(rdfs:label "mucosa of left hepatic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of upper lip) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a upper lip [Automatically generated definition].") +AnnotationAssertion( "FMA:59832") +AnnotationAssertion( "NCIT:C12224") +AnnotationAssertion( "SCTID:362088009") +AnnotationAssertion(rdfs:label "mucosa of upper lip") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mucosa of lower lip) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a lower lip [Automatically generated definition].") +AnnotationAssertion( "FMA:59833") +AnnotationAssertion( "NCIT:C12225") +AnnotationAssertion( "SCTID:362089001") AnnotationAssertion(rdfs:label "mucosa of lower lip") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mucosa of gallbladder) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a gallbladder [Automatically generated definition].") +AnnotationAssertion( "FMA:14662") +AnnotationAssertion( "SCTID:362196002") +AnnotationAssertion(rdfs:label "mucosa of gallbladder") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mucosa of bronchiole) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a bronchiole [Automatically generated definition].") +AnnotationAssertion( "FMA:62774") +AnnotationAssertion( "SCTID:10887006") AnnotationAssertion(rdfs:label "mucosa of bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36001,6 +55803,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mucosa of terminal bronchiole) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a terminal bronchiole [Automatically generated definition].") +AnnotationAssertion( "FMA:263232") AnnotationAssertion(rdfs:label "mucosa of terminal bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36008,6 +55812,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mucosa of respiratory bronchiole) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a respiratory bronchiole [Automatically generated definition].") +AnnotationAssertion( "FMA:263238") AnnotationAssertion(rdfs:label "mucosa of respiratory bronchiole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36015,8 +55821,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (external female genitalia) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "An external genitalia that is part of a female reproductive system [Automatically generated definition].") +AnnotationAssertion( "BTO:0003100") +AnnotationAssertion( "EMAPA:30984") +AnnotationAssertion( "FMA:45649") +AnnotationAssertion( "SCTID:362234008") +AnnotationAssertion( "galen:FemaleExternalGenitalia") +AnnotationAssertion(rdfs:comment "TODO: Relabel. Make distinct organ class. See https://github.com/obophenotype/uberon/issues/547") AnnotationAssertion(rdfs:label "external female genitalia") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36025,6 +55836,7 @@ DisjointClasses( (immune organ) +AnnotationAssertion(Annotation( "OBOL:automatic") "An organ that is part of a immune system [Automatically generated definition].") AnnotationAssertion(rdfs:label "immune organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36032,6 +55844,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (hemolymphoid system gland) +AnnotationAssertion(Annotation( "OBOL:automatic") "A gland that is part of a hemolymphoid system [Automatically generated definition].") +AnnotationAssertion( "EMAPA:18766") +AnnotationAssertion( "MA:0002962") AnnotationAssertion(rdfs:label "hemolymphoid system gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36039,12 +55854,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural groove) +AnnotationAssertion(Annotation( "GO:0001842") Annotation( "Wikipedia:Neural_groove") Annotation( "http://orcid.org/0000-0002-6601-2165") "The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds.") +AnnotationAssertion( "AAO:0011071") +AnnotationAssertion( "EMAPA:35594") +AnnotationAssertion( "FMA:295624") +AnnotationAssertion( "NCIT:C34224") +AnnotationAssertion( "SCTID:361463007") +AnnotationAssertion( "Wikipedia:Neural_groove") +AnnotationAssertion( "XAO:0000248") +AnnotationAssertion( "neuronames:1363") AnnotationAssertion(rdfs:label "neural groove") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (neural fold) +AnnotationAssertion(Annotation( "GO:0001842") Annotation( "MP:0011256") Annotation( "Wikipedia:Neural_fold") "One of the two elevated edges of the neural groove[GO,MP].") +AnnotationAssertion( "EHDAA2:0001249") +AnnotationAssertion( "FMA:295618") +AnnotationAssertion( "NCIT:C34223") +AnnotationAssertion( "SCTID:361461009") +AnnotationAssertion( "Wikipedia:Neural_fold") +AnnotationAssertion( "XAO:0004087") +AnnotationAssertion( "neuronames:1364") AnnotationAssertion(rdfs:label "neural fold") SubClassOf( ) SubClassOf( ) @@ -36054,14 +55886,35 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (left ventricular trabecular myocardium) + +AnnotationAssertion(Annotation( "GO:0003225") "Missing definition for term UBERON:0005064. Please replace it using linked reference.") +AnnotationAssertion(rdfs:label "left ventricular trabecular myocardium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (right ventricular trabecular myocardium) + +AnnotationAssertion(Annotation( "GO:0003227") "Missing definition for term UBERON:0005066. Please replace it using linked reference.") +AnnotationAssertion(rdfs:label "right ventricular trabecular myocardium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (neural rod) +AnnotationAssertion(Annotation( "GO:0014024") Annotation( "ZFA:0000133") "A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN].") +AnnotationAssertion( "EFO:0003498") +AnnotationAssertion( "TAO:0000133") +AnnotationAssertion( "ZFA:0000133") AnnotationAssertion(rdfs:label "neural rod") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (hindbrain-spinal cord boundary) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord.") AnnotationAssertion(rdfs:label "hindbrain-spinal cord boundary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36072,6 +55925,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tube lumen) +AnnotationAssertion(Annotation( "GO:0060609") "A hole in a tube[GO].") +AnnotationAssertion( "AEO:0000078") +AnnotationAssertion( "EHDAA2:0004618") +AnnotationAssertion( "RETIRED_EHDAA2:0003078") AnnotationAssertion(rdfs:label "tube lumen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36079,6 +55936,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ectodermal placode) +AnnotationAssertion(Annotation( "GO:0060788") "An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO].") +AnnotationAssertion( "AEO:0000218") AnnotationAssertion(rdfs:label "ectodermal placode") SubClassOf( ) SubClassOf( ) @@ -36086,6 +55945,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (muscle structure) +AnnotationAssertion(Annotation( "GO:0061061") "Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO].") +AnnotationAssertion( "FMA:30316") AnnotationAssertion(rdfs:label "muscle structure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36093,17 +55954,25 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right horn of sinus venosus) +AnnotationAssertion( "EHDAA2:0001841") +AnnotationAssertion( "EHDAA:484") +AnnotationAssertion( "EMAPA:16239") +AnnotationAssertion( "FMA:70318") +AnnotationAssertion( "VHOG:0000489") AnnotationAssertion(rdfs:label "right horn of sinus venosus") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (epithelial bud) +AnnotationAssertion(Annotation( "GO:0060572") "A bud is a protrusion that forms from an epithelial sheet by localized folding.") +AnnotationAssertion( "BTO:0001639") AnnotationAssertion(rdfs:label "epithelial bud") SubClassOf( ) # Class: (reproductive structure) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any anatomical structure that is part of the reproductive system.") AnnotationAssertion(rdfs:label "reproductive structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36111,11 +55980,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelial fold) +AnnotationAssertion(Annotation( "GO:0060571") "An epithelial sheet bent on a linear axis.") AnnotationAssertion(rdfs:label "epithelial fold") SubClassOf( ) # Class: (parenchyma of central nervous system) +AnnotationAssertion(Annotation( "CL:tm") Annotation( "https://github.com/obophenotype/uberon/issues/8") "The functional tissue of the central nervous system consisting of neurons and glial cells.") AnnotationAssertion(rdfs:label "parenchyma of central nervous system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36124,18 +55995,44 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (multi cell part structure) +AnnotationAssertion(Annotation( "CARO:0001000") "A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part.") +AnnotationAssertion( "AAO:0011000") +AnnotationAssertion( "CARO:0001000") +AnnotationAssertion( "FMA:83115") AnnotationAssertion(rdfs:label "multi cell part structure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (interstitial tissue) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/tissue") "Connective tissue between the cellular elements of a structure.") +AnnotationAssertion( "FMA:86301") +AnnotationAssertion( "SCTID:85293002") AnnotationAssertion(rdfs:label "interstitial tissue") SubClassOf( ) +# Class: (hepatic duct) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion).") +AnnotationAssertion( "EHDAA2:0000741") +AnnotationAssertion( "EHDAA:3049") +AnnotationAssertion( "EMAPA:16843") +AnnotationAssertion( "FMA:71891") +AnnotationAssertion( "MA:0000357") +AnnotationAssertion( "NCIT:C32730") +AnnotationAssertion( "SCTID:245399002") +AnnotationAssertion( "VHOG:0000219") +AnnotationAssertion( "galen:HepaticDuct") +AnnotationAssertion(rdfs:label "hepatic duct") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (abdomen element) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland.") +AnnotationAssertion( "MA:0000522") +AnnotationAssertion( "SCTID:272631008") AnnotationAssertion(rdfs:label "abdomen element") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36143,6 +56040,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdominal segment element) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region.") +AnnotationAssertion( "MA:0000529") AnnotationAssertion(rdfs:label "abdominal segment element") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36150,6 +56049,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dorsal region element) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back.") +AnnotationAssertion( "MA:0001901") AnnotationAssertion(rdfs:label "dorsal region element") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36157,6 +56058,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trunk region element) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions.") +AnnotationAssertion( "MA:0000516") AnnotationAssertion(rdfs:label "trunk region element") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36164,6 +56067,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic cavity element) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli.") +AnnotationAssertion( "MA:0000557") AnnotationAssertion(rdfs:label "thoracic cavity element") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36172,6 +56077,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic segment organ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions.") +AnnotationAssertion( "MA:0000563") AnnotationAssertion(rdfs:label "thoracic segment organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36179,13 +56086,71 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic vein) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vein that is part of a thorax [Automatically generated definition].") +AnnotationAssertion( "MA:0002235") +AnnotationAssertion( "NCIT:C53142") +AnnotationAssertion( "SCTID:281472008") AnnotationAssertion(rdfs:label "thoracic vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (trachea gland) + +AnnotationAssertion(Annotation( "ISBN:1451113412") Annotation( "MGI:Anna") Annotation( "PMID:15973734") Annotation( "http://medical-dictionary.thefreedictionary.com/tracheal+glands") Annotation( "https://github.com/obophenotype/uberon/issues/1197") "A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen.") +AnnotationAssertion( "EMAPA:36574") +AnnotationAssertion( "FMA:7473") +AnnotationAssertion( "MA:0002937") +AnnotationAssertion( "SCTID:197423006") +AnnotationAssertion(rdfs:label "trachea gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (liver right lobe parenchyma) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A parenchyma that is part of a right lobe of liver [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0001010") +AnnotationAssertion( "EMAPA:18317") +AnnotationAssertion( "FMA:71657") +AnnotationAssertion( "VHOG:0000840") +AnnotationAssertion(rdfs:label "liver right lobe parenchyma") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (liver left lobe parenchyma) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A parenchyma that is part of a left lobe of liver [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0001002") +AnnotationAssertion( "EMAPA:18310") +AnnotationAssertion( "FMA:71658") +AnnotationAssertion( "VHOG:0000839") +AnnotationAssertion(rdfs:label "liver left lobe parenchyma") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (medial-nasal process ectoderm) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An ectoderm that is part of a medial nasal prominence [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0001078") +AnnotationAssertion( "EMAPA:16809") +AnnotationAssertion( "FMA:312675") +AnnotationAssertion( "VHOG:0000803") +AnnotationAssertion(rdfs:label "medial-nasal process ectoderm") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (optic eminence ectoderm) +AnnotationAssertion(Annotation( "OBOL:automatic") "An ectoderm that is part of a optic eminence [Automatically generated definition].") +AnnotationAssertion( "EHDAA:940") +AnnotationAssertion( "EMAPA:16539") +AnnotationAssertion( "RETIRED_EHDAA2:0001309") +AnnotationAssertion( "VHOG:0001105") AnnotationAssertion(rdfs:label "optic eminence ectoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36193,11 +56158,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (basal plate metencephalon) +AnnotationAssertion( "EHDAA2:0001154") +AnnotationAssertion( "EMAPA:17078") +AnnotationAssertion( "VHOG:0000320") AnnotationAssertion(rdfs:label "basal plate metencephalon") SubClassOf( ) # Class: (interventricular septum endocardium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endocardium that is part of a interventricular septum [Automatically generated definition].") +AnnotationAssertion( "EHDAA2:0000886") +AnnotationAssertion( "EHDAA2:0000887") +AnnotationAssertion( "FMA:83584") +AnnotationAssertion( "VHOG:0000615") AnnotationAssertion(rdfs:label "interventricular septum endocardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36205,6 +56178,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bulbus cordis myocardium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A myocardium that is part of a bulbus cordis [Automatically generated definition].") +AnnotationAssertion( "EMAPA:36488") +AnnotationAssertion( "VHOG:0000609") AnnotationAssertion(rdfs:label "bulbus cordis myocardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36212,6 +56188,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (stomatodeum gland) +AnnotationAssertion(Annotation( "OBOL:automatic") "A gland that is part of a stomodeum.") +AnnotationAssertion( "VHOG:0000658") AnnotationAssertion(rdfs:label "stomatodeum gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36219,6 +56197,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (yolk sac cavity) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that is part of a yolk sac [Automatically generated definition].") +AnnotationAssertion( "EMAPA:16055") +AnnotationAssertion( "FMA:63942") +AnnotationAssertion( "VHOG:0000843") AnnotationAssertion(rdfs:label "yolk sac cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36228,6 +56210,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (head mesenchyme) +AnnotationAssertion(Annotation( "ISBN:0683400088") Annotation( "MP:0011260") "Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells.") +AnnotationAssertion( "EFO:0003492") +AnnotationAssertion( "EHDAA2:0000732") +AnnotationAssertion( "EHDAA:179") +AnnotationAssertion( "EMAPA:16098") +AnnotationAssertion( "EMAPA_RETIRED:16269") +AnnotationAssertion( "FMA:76622") +AnnotationAssertion( "TAO:0000113") +AnnotationAssertion( "VHOG:0000332") +AnnotationAssertion( "ZFA:0000113") AnnotationAssertion(rdfs:label "head mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36237,6 +56229,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trunk mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing trunk.") +AnnotationAssertion( "EFO:0003485") +AnnotationAssertion( "EHDAA2:0002092") +AnnotationAssertion( "EHDAA:377") +AnnotationAssertion( "EMAPA:16177") +AnnotationAssertion( "TAO:0000081") +AnnotationAssertion( "VHOG:0000281") +AnnotationAssertion( "ZFA:0000081") AnnotationAssertion(rdfs:label "trunk mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36246,12 +56246,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (myelencephalon) +AnnotationAssertion(Annotation( "BTO:0000758") Annotation( "Wikipedia:Myelencephalon") "The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP].") +AnnotationAssertion( "BTO:0000758") +AnnotationAssertion( "CALOHA:TS-0607") +AnnotationAssertion( "CALOHA:TS-2365") +AnnotationAssertion( "DHBA:10662") +AnnotationAssertion( "EHDAA2:0001207") +AnnotationAssertion( "EHDAA:5526") +AnnotationAssertion( "EMAPA:17082") +AnnotationAssertion( "HBA:9512") +AnnotationAssertion( "MA:0000205") +AnnotationAssertion( "VHOG:0000456") +AnnotationAssertion( "Wikipedia:Myelencephalon") AnnotationAssertion(rdfs:label "myelencephalon") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (embryonic tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of tissue that is part of an embryo.") +AnnotationAssertion( "CALOHA:TS-2100") AnnotationAssertion(rdfs:label "embryonic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36259,6 +56273,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (extraembryonic tissue) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo.") +AnnotationAssertion( "BTO:0003360") +AnnotationAssertion( "CALOHA:TS-2119") +AnnotationAssertion( "EFO:0001406") +AnnotationAssertion( "MAT:0000061") +AnnotationAssertion( "MIAA:0000061") AnnotationAssertion(rdfs:label "extraembryonic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36266,6 +56286,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endocardial endothelium) +AnnotationAssertion(Annotation( "UBERON:cjm") "The endothelial lining of the endocardium.") +AnnotationAssertion( "FMA:83596") AnnotationAssertion(rdfs:label "endocardial endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36273,6 +56295,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pulmonary artery endothelium) +AnnotationAssertion(Annotation( "GO:0061155") "An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO].") +AnnotationAssertion( "BTO:0000137") AnnotationAssertion(rdfs:label "pulmonary artery endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36280,6 +56304,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (oral lamina propria) +AnnotationAssertion(Annotation( "OBOL:automatic") "A lamina propria that is part of a mucosa of oral region.") +AnnotationAssertion( "EMAPA:26947") AnnotationAssertion(rdfs:label "oral lamina propria") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36287,6 +56313,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow tract of ventricle) +AnnotationAssertion(Annotation( "Wikipedia:Ventricular_outflow_tract") "A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP].") +AnnotationAssertion( "FMA:13225") +AnnotationAssertion( "Wikipedia:Ventricular_outflow_tract") +AnnotationAssertion( "XAO:0004140") AnnotationAssertion(rdfs:label "outflow tract of ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36294,6 +56324,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow tract aortic component) +AnnotationAssertion(Annotation( "OBOL:automatic") "An outflow tract that is part of a aorta.") +AnnotationAssertion( "EHDAA2:0001353") +AnnotationAssertion( "EMAPA:17329") +AnnotationAssertion( "MA:0000101") +AnnotationAssertion( "VHOG:0001394") AnnotationAssertion(rdfs:label "outflow tract aortic component") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36301,11 +56336,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow tract pulmonary component) +AnnotationAssertion( "EHDAA2:0001359") +AnnotationAssertion( "EHDAA:4401") +AnnotationAssertion( "EMAPA:17330") +AnnotationAssertion( "MA:0000102") +AnnotationAssertion( "VHOG:0001395") AnnotationAssertion(rdfs:label "outflow tract pulmonary component") SubClassOf( ) # Class: (photoreceptor array) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An array of photoreceptors and any supporting cells found in an eye.") AnnotationAssertion(rdfs:label "photoreceptor array") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36315,6 +56356,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (transparent eye structure) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array.") AnnotationAssertion(rdfs:label "transparent eye structure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36322,11 +56364,35 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (carotid artery segment) +AnnotationAssertion(Annotation( "Wikipedia:Carotid_artery") Annotation( "https://sourceforge.net/tracker/?func=detail&aid=3486870&group_id=76834&atid=994764") "One of: the common carotid artery, or its branches, the external and internal carotid arteries.") +AnnotationAssertion( "AAO:0010217") +AnnotationAssertion( "BTO:0000168") +AnnotationAssertion( "CALOHA:TS-0116") +AnnotationAssertion( "EFO:0000818") +AnnotationAssertion( "EHDAA:6385") +AnnotationAssertion( "EMAPA:18609") +AnnotationAssertion( "EV:0100379") +AnnotationAssertion( "FMA:70504") +AnnotationAssertion( "GAID:478") +AnnotationAssertion( "MA:0001925") +AnnotationAssertion( "MAT:0000501") +AnnotationAssertion( "MESH:D002339") +AnnotationAssertion( "NCIT:C12687") +AnnotationAssertion( "SCTID:362040006") +AnnotationAssertion( "SCTID:69105007") +AnnotationAssertion( "TAO:0000097") +AnnotationAssertion( "VHOG:0000266") +AnnotationAssertion( "Wikipedia:Carotid_artery") +AnnotationAssertion( "ZFA:0000097") +AnnotationAssertion( "galen:CarotidArtery") AnnotationAssertion(rdfs:label "carotid artery segment") SubClassOf( ) # Class: (female reproductive gland) +AnnotationAssertion(Annotation( "OBOL:automatic") "A sex gland that is part of a female reproductive system.") +AnnotationAssertion( "BTO:0000254") +AnnotationAssertion( "MA:0000383") AnnotationAssertion(rdfs:label "female reproductive gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36334,6 +56400,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (alimentary part of gastrointestinal system) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The part of the digestive system that excludes the hepatobiliary system.") +AnnotationAssertion( "BTO:0000058") +AnnotationAssertion( "CALOHA:TS-0407") +AnnotationAssertion( "EHDAA2:0000110") +AnnotationAssertion( "EHDAA:514") +AnnotationAssertion( "EMAPA:16246") +AnnotationAssertion( "FMA:71132") +AnnotationAssertion( "GAID:294") +AnnotationAssertion( "MA:0000323") +AnnotationAssertion( "MESH:D041981") +AnnotationAssertion( "NCIT:C12378") +AnnotationAssertion( "SCTID:373871007") +AnnotationAssertion( "VHOG:0000412") +AnnotationAssertion( "galen:GastrointestinalTract") AnnotationAssertion(rdfs:label "alimentary part of gastrointestinal system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36341,6 +56421,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage bud) +AnnotationAssertion(Annotation( "OBOL:automatic") "A limb bud that develops into a forelimb or pectoral fin.") +AnnotationAssertion( "EFO:0003430") +AnnotationAssertion( "TAO:0000141") +AnnotationAssertion( "VHOG:0001754") +AnnotationAssertion( "VHOG_RETIRED:0001259") +AnnotationAssertion( "ZFA:0000141") +AnnotationAssertion(rdfs:comment "at this time we have no need to name a more specific 'pectoral fin bud' class, but we may in future") AnnotationAssertion(rdfs:label "pectoral appendage bud") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36350,6 +56437,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage apical ectodermal ridge) +AnnotationAssertion(Annotation( "OBOL:automatic") "An apical ectodermal ridge that is part of a pectoral appendage bud.") +AnnotationAssertion( "EFO:0003487") +AnnotationAssertion( "EHDAA2:0000138") +AnnotationAssertion( "EMAPA:16778") +AnnotationAssertion( "TAO:0000085") +AnnotationAssertion( "TAO:0000736") +AnnotationAssertion( "VHOG:0001064") +AnnotationAssertion( "ZFA:0000085") AnnotationAssertion(rdfs:label "pectoral appendage apical ectodermal ridge") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36358,15 +56453,23 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (developing anatomical structure) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion( "AEO:0000125") +AnnotationAssertion( "CALOHA:TS-2122") +AnnotationAssertion( "EHDAA2:0003125") +AnnotationAssertion( "FMA:292313") +AnnotationAssertion( "MIAA:0000019") AnnotationAssertion(rdfs:label "developing anatomical structure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (presumptive neural retina) +AnnotationAssertion(Annotation( "ZFIN:curator") "Portion of tissue that is the inner layer of the optic cup and will become the neural retina.") +AnnotationAssertion( "EHDAA2:0001304") +AnnotationAssertion( "EMAPA:16675") +AnnotationAssertion( "TAO:0001071") +AnnotationAssertion( "VHOG:0000490") +AnnotationAssertion( "ZFA:0001071") AnnotationAssertion(rdfs:label "presumptive neural retina") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36376,6 +56479,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lens vesicle) +AnnotationAssertion(Annotation( "ZFIN:curator") Annotation( "https://sourceforge.net/tracker/?func=detail&atid=994726&aid=3514998&group_id=76834") "Portion of tissue that gives rise to the lens.") +AnnotationAssertion( "EHDAA2:0000983") +AnnotationAssertion( "EHDAA:4737") +AnnotationAssertion( "EMAPA:17163") +AnnotationAssertion( "SCTID:361510002") +AnnotationAssertion( "TAO:0002205") +AnnotationAssertion( "VHOG:0001163") +AnnotationAssertion( "ZFA:0001679") AnnotationAssertion(rdfs:label "lens vesicle") SubClassOf( ) SubClassOf( ) @@ -36383,6 +56494,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (corneal primordium) +AnnotationAssertion(Annotation( "ZFIN:ZDB-PUB-061010-3") "Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea.") +AnnotationAssertion( "TAO:0002188") +AnnotationAssertion( "ZFA:0001688") AnnotationAssertion(rdfs:label "corneal primordium") SubClassOf( ) SubClassOf( ) @@ -36392,6 +56506,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vagal neural crest) +AnnotationAssertion(Annotation( "ZFIN:curator") "Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA].") +AnnotationAssertion( "EHDAA2:0002156") +AnnotationAssertion( "EHDAA:669") +AnnotationAssertion( "TAO:0000818") +AnnotationAssertion( "VHOG:0001208") +AnnotationAssertion( "XAO:0004191") +AnnotationAssertion( "ZFA:0000818") AnnotationAssertion(rdfs:label "vagal neural crest") SubClassOf( ) SubClassOf( ) @@ -36399,6 +56520,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aortic sac) +AnnotationAssertion(Annotation( "MP:0012510") "The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates.") +AnnotationAssertion( "EHDAA2:0004145") +AnnotationAssertion( "EHDAA:9826") +AnnotationAssertion( "EMAPA:36461") +AnnotationAssertion( "FMA:71008") +AnnotationAssertion( "RETIRED_EHDAA2:0000133") +AnnotationAssertion( "SCTID:361527005") AnnotationAssertion(rdfs:label "aortic sac") SubClassOf( ) SubClassOf( ) @@ -36408,13 +56536,53 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cervical region) +AnnotationAssertion( "FMA:24219") +AnnotationAssertion( "SCTID:123958008") AnnotationAssertion(rdfs:label "cervical region") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (common hepatic artery) + +AnnotationAssertion(Annotation( "Wikipedia:Common_hepatic_artery") "In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:.") +AnnotationAssertion( "EHDAA2:0000308") +AnnotationAssertion( "EHDAA:8570") +AnnotationAssertion( "FMA:14771") +AnnotationAssertion( "MA:0003094") +AnnotationAssertion( "SCTID:244263001") +AnnotationAssertion( "Wikipedia:Common_hepatic_artery") +AnnotationAssertion( "galen:CommonHepaticArtery") +AnnotationAssertion(rdfs:label "common hepatic artery") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (foramen rotundum) + +AnnotationAssertion(Annotation( "Wikipedia:Foramen_rotundum") "The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa.") +AnnotationAssertion( "AAO:0000194") +AnnotationAssertion( "EHDAA2:0000552") +AnnotationAssertion( "EHDAA:10629") +AnnotationAssertion( "EMAPA:18712") +AnnotationAssertion( "FMA:53154") +AnnotationAssertion( "SCTID:369439002") +AnnotationAssertion( "VHOG:0001543") +AnnotationAssertion( "Wikipedia:Foramen_rotundum") +AnnotationAssertion(rdfs:label "foramen rotundum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (left vitelline vein) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vitelline vein that is in the left side of a multicellular organism.") +AnnotationAssertion( "EHDAA2:0000971") +AnnotationAssertion( "EMAPA:16380") +AnnotationAssertion( "EMAPA:16698") +AnnotationAssertion( "FMA:70307") +AnnotationAssertion( "SCTID:361446008") AnnotationAssertion(rdfs:label "left vitelline vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36423,6 +56591,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right vitelline vein) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vitelline vein that is in the right side of a multicellular organism.") +AnnotationAssertion( "EHDAA2:0001766") +AnnotationAssertion( "EMAPA:16381") +AnnotationAssertion( "EMAPA:16699") +AnnotationAssertion( "FMA:70306") +AnnotationAssertion( "SCTID:361445007") AnnotationAssertion(rdfs:label "right vitelline vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36431,12 +56605,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sulcus limitans of neural tube) +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/Sulcus+limitans") Annotation( "http://www.ncbi.nlm.nih.gov/books/NBK10047") "A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD].") +AnnotationAssertion( "BAMS:slim") +AnnotationAssertion( "BAMS:slm") +AnnotationAssertion( "neuronames:629") AnnotationAssertion(rdfs:label "sulcus limitans of neural tube") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (vitelline vein) +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0010666") "The paired veins that carry blood from the yolk sac back to the embryo.") +AnnotationAssertion( "EMAPA:36021") +AnnotationAssertion( "FMA:70305") +AnnotationAssertion( "NCIT:C34329") +AnnotationAssertion( "RETIRED_EHDAA2:0002209") +AnnotationAssertion( "SCTID:2730004") +AnnotationAssertion( "SCTID:308832003") +AnnotationAssertion( "VHOG:0000401") +AnnotationAssertion( "Wikipedia:Vitelline_veins") +AnnotationAssertion( "XAO:0000376") +AnnotationAssertion( "XAO:0004147") AnnotationAssertion(rdfs:label "vitelline vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36445,18 +56634,45 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural tube lateral wall) +AnnotationAssertion(Annotation( "ZFA:0001435") "Portion of tissue on the side of the lumen of the neural tube.") +AnnotationAssertion( "EHDAA2:0001257") +AnnotationAssertion( "EHDAA:2873") +AnnotationAssertion( "EHDAA:912") +AnnotationAssertion( "EMAPA:16166") +AnnotationAssertion( "TAO:0001435") +AnnotationAssertion( "VHOG:0000513") +AnnotationAssertion( "ZFA:0001435") AnnotationAssertion(rdfs:label "neural tube lateral wall") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (non-neural ectoderm) +AnnotationAssertion( "EFO:0003643") +AnnotationAssertion( "EHDAA:257") +AnnotationAssertion( "EMAPA:16074") +AnnotationAssertion( "RETIRED_EHDAA2:0001273") +AnnotationAssertion( "TAO:0001178") +AnnotationAssertion( "VHOG:0001372") +AnnotationAssertion( "XAO:0004091") +AnnotationAssertion( "ZFA:0001178") +AnnotationAssertion(rdfs:comment "Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998).") AnnotationAssertion(rdfs:label "non-neural ectoderm") SubClassOf( ) SubClassOf( ) # Class: (primitive heart tube) +AnnotationAssertion(Annotation( "ZFA:0000149") "Multi-tissue structure that arises from the heart rudiment and will become the heart tube.") +AnnotationAssertion( "EHDAA2:0001512") +AnnotationAssertion( "EHDAA:424") +AnnotationAssertion( "EHDAA:436") +AnnotationAssertion( "EMAPA:16215") +AnnotationAssertion( "FMA:321916") +AnnotationAssertion( "SCTID:361522004") +AnnotationAssertion( "TAO:0000149") +AnnotationAssertion( "Wikipedia:Primitive_heart_tube") +AnnotationAssertion( "ZFA:0000149") AnnotationAssertion(rdfs:label "primitive heart tube") SubClassOf( ) SubClassOf( ) @@ -36465,6 +56681,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (rhombomere lateral wall) +AnnotationAssertion(Annotation( "OBOL:automatic") "A neural tube lateral wall that is part of a rhombomere.") +AnnotationAssertion( "EMAPA:32819") +AnnotationAssertion( "EMAPA:35364") AnnotationAssertion(rdfs:label "rhombomere lateral wall") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36472,6 +56691,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trigeminal neural crest) +AnnotationAssertion(Annotation( "ZFA:0000080") "Cranial neural crest which gives rise to the trigeminal ganglion.") +AnnotationAssertion( "EFO:0003484") +AnnotationAssertion( "EHDAA2:0002083") +AnnotationAssertion( "EHDAA:667") +AnnotationAssertion( "EMAPA:16170") +AnnotationAssertion( "TAO:0000080") +AnnotationAssertion( "VHOG:0000269") +AnnotationAssertion( "ZFA:0000080") AnnotationAssertion(rdfs:label "trigeminal neural crest") SubClassOf( ) SubClassOf( ) @@ -36480,6 +56707,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gonad primordium) +AnnotationAssertion(Annotation( "ZFA:0001262") "Portion of tissue that gives rise to the immature gonad.") +AnnotationAssertion( "EFO:0003651") +AnnotationAssertion( "EHDAA:5927") +AnnotationAssertion( "EMAPA:17204") +AnnotationAssertion( "RETIRED_EHDAA2:0002148") +AnnotationAssertion( "TAO:0001262") +AnnotationAssertion( "WBbt:0008366") +AnnotationAssertion( "ZFA:0001262") AnnotationAssertion(rdfs:label "gonad primordium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36487,6 +56722,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (head somite) +AnnotationAssertion(Annotation( "PMID:11830559") "Somite located in the head region, caudal to the otic vesicle.") +AnnotationAssertion( "EHDAA2:0003437") +AnnotationAssertion( "EMAPA:16172") +AnnotationAssertion( "XAO:0000313") AnnotationAssertion(rdfs:label "head somite") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36497,6 +56736,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung primordium) +AnnotationAssertion(Annotation( "XAO:0001002") "A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum.") +AnnotationAssertion( "AAO:0011059") +AnnotationAssertion( "EFO:0002578") +AnnotationAssertion( "EMAPA:36007") +AnnotationAssertion( "XAO:0001002") AnnotationAssertion(rdfs:label "lung primordium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36505,13 +56749,49 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trunk somite) +AnnotationAssertion(Annotation( "OBOL:automatic") "A somite that is part of a trunk.") +AnnotationAssertion( "AAO:0010385") +AnnotationAssertion( "EHDAA2:0003438") +AnnotationAssertion( "EMAPA:16184") +AnnotationAssertion( "XAO:0000314") AnnotationAssertion(rdfs:label "trunk somite") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (dorsal mesogastrium) + +AnnotationAssertion(Annotation( "Wikipedia:Dorsal_mesentery") "The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum.") +AnnotationAssertion( "EHDAA2:0000416") +AnnotationAssertion( "EHDAA:3001") +AnnotationAssertion( "EMAPA:17025") +AnnotationAssertion( "MA:0001618") +AnnotationAssertion( "NCIT:C34142") +AnnotationAssertion( "VHOG:0000352") +AnnotationAssertion( "Wikipedia:Dorsal_mesentery") +AnnotationAssertion(rdfs:label "dorsal mesogastrium") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (extrahepatic part of hepatic duct) + +AnnotationAssertion( "EMAPA:16844") +AnnotationAssertion( "MA:0001636") +AnnotationAssertion( "VHOG:0000215") +AnnotationAssertion(rdfs:label "extrahepatic part of hepatic duct") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (left dorsal aorta) +AnnotationAssertion( "EHDAA2:0000936") +AnnotationAssertion( "EHDAA:404") +AnnotationAssertion( "EMAPA:16205") +AnnotationAssertion( "MA:0000478") +AnnotationAssertion( "SCTID:361403005") +AnnotationAssertion( "VHOG:0000484") AnnotationAssertion(rdfs:label "left dorsal aorta") SubClassOf( ) SubClassOf( ) @@ -36519,14 +56799,67 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lens anterior epithelium) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex.") +AnnotationAssertion( "EHDAA2:0000984") +AnnotationAssertion( "EHDAA:9059") +AnnotationAssertion( "EMAPA:17304") +AnnotationAssertion( "EMAPA:17839") +AnnotationAssertion( "FMA:70612") +AnnotationAssertion( "MA:0001302") +AnnotationAssertion( "NCIT:C33641") +AnnotationAssertion( "RETIRED_EHDAA2:0000976") +AnnotationAssertion( "SCTID:362521008") +AnnotationAssertion( "VHOG:0001425") AnnotationAssertion(rdfs:label "lens anterior epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mesenteric artery) + +AnnotationAssertion(Annotation( "MESH:A07.231.114.565") Annotation( "Wikipedia:Mesenteric_artery") "Arteries which arise from the abdominal aorta and distribute to most of the intestines.") +AnnotationAssertion( "BTO:0000779") +AnnotationAssertion( "EHDAA2:0001123") +AnnotationAssertion( "EHDAA:4343") +AnnotationAssertion( "EMAPA:17312") +AnnotationAssertion( "MA:0002003") +AnnotationAssertion( "MESH:D008638") +AnnotationAssertion( "NCIT:C52975") +AnnotationAssertion( "SCTID:281084003") +AnnotationAssertion( "VHOG:0001117") +AnnotationAssertion( "Wikipedia:Mesenteric_artery") +AnnotationAssertion( "XAO:0000370") +AnnotationAssertion(rdfs:label "mesenteric artery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mesenteric vein) + +AnnotationAssertion(Annotation( "MESH:A07.231.908.670.385") Annotation( "Wikipedia:Mesenteric_vein") "A vein that returns blood from the intestines.") +AnnotationAssertion( "BTO:0002781") +AnnotationAssertion( "EHDAA:4442") +AnnotationAssertion( "EMAPA:17348") +AnnotationAssertion( "MA:0002177") +AnnotationAssertion( "MESH:D008642") +AnnotationAssertion( "NCIT:C53055") +AnnotationAssertion( "RETIRED_EHDAA2:0001125") +AnnotationAssertion( "SCTID:304045008") +AnnotationAssertion( "Wikipedia:Mesenteric_vein") +AnnotationAssertion(rdfs:label "mesenteric vein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (right dorsal aorta) +AnnotationAssertion( "EHDAA2:0001720") +AnnotationAssertion( "EHDAA:406") +AnnotationAssertion( "EMAPA:16206") +AnnotationAssertion( "MA:0000479") +AnnotationAssertion( "SCTID:361404004") +AnnotationAssertion( "VHOG:0000485") AnnotationAssertion(rdfs:label "right dorsal aorta") SubClassOf( ) SubClassOf( ) @@ -36534,12 +56867,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (extraembryonic membrane) +AnnotationAssertion(Annotation( "ISBN:0073040584") "Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo.") +AnnotationAssertion( "EHDAA2:0004714") +AnnotationAssertion( "FMA:305915") +AnnotationAssertion( "SCTID:362840007") AnnotationAssertion(rdfs:label "extraembryonic membrane") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pyloric region epithelium) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a pylorus.") +AnnotationAssertion( "EHDAA2:0001582") +AnnotationAssertion( "EMAPA:17633") +AnnotationAssertion( "RETIRED_EHDAA2:0001927") +AnnotationAssertion(rdfs:label "pyloric region epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (anterior chamber epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a anterior chamber of eyeball.") +AnnotationAssertion( "EHDAA2:0000130") AnnotationAssertion(rdfs:label "anterior chamber epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36547,6 +56897,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lens vesicle epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a lens vesicle.") +AnnotationAssertion( "EHDAA2:0000987") +AnnotationAssertion( "EMAPA:17165") +AnnotationAssertion( "VHOG:0000532") AnnotationAssertion(rdfs:label "lens vesicle epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36554,6 +56908,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (4th arch ectoderm) +AnnotationAssertion(Annotation( "OBOL:automatic") "An ectoderm that is part of a pharyngeal arch 4.") +AnnotationAssertion( "EHDAA2:0004032") +AnnotationAssertion( "EMAPA:16762") +AnnotationAssertion( "EMAPA:16764") +AnnotationAssertion( "EMAPA:16768") +AnnotationAssertion( "RETIRED_EHDAA2:0000094") +AnnotationAssertion( "VHOG:0001095") AnnotationAssertion(rdfs:label "4th arch ectoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36561,6 +56922,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (4th arch endoderm) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endoderm that is part of a pharyngeal arch 4.") +AnnotationAssertion( "EHDAA2:0004033") +AnnotationAssertion( "EMAPA:16765") +AnnotationAssertion( "EMAPA:16767") +AnnotationAssertion( "EMAPA:16769") +AnnotationAssertion( "RETIRED_EHDAA2:0000095") +AnnotationAssertion( "VHOG:0001092") AnnotationAssertion(rdfs:label "4th arch endoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36568,6 +56936,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (peritoneal cavity mesothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesothelium that is part of a peritoneal cavity.") +AnnotationAssertion( "BTO:0003156") +AnnotationAssertion( "EHDAA2:0001447") +AnnotationAssertion( "EMAPA:16139") +AnnotationAssertion( "FMA:18147") +AnnotationAssertion( "SCTID:34073007") AnnotationAssertion(rdfs:label "peritoneal cavity mesothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36575,6 +56949,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right lung endothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of a right lung.") +AnnotationAssertion( "EHDAA2:0001755") AnnotationAssertion(rdfs:label "right lung endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36583,14 +56959,33 @@ SubClassOf( (left lung endothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of a left lung.") +AnnotationAssertion( "EHDAA2:0000961") AnnotationAssertion(rdfs:label "left lung endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ) +# Class: (midgut dorsal mesentery) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A dorsal mesentery that is part of a midgut.") +AnnotationAssertion( "EMAPA:16722") +AnnotationAssertion( "EMAPA:17040") +AnnotationAssertion( "EMAPA:18671") +AnnotationAssertion( "RETIRED_EHDAA2:0001187") +AnnotationAssertion( "SCTID:361434009") +AnnotationAssertion(rdfs:label "midgut dorsal mesentery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (lens vesicle cavity) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that is part of a lens vesicle.") +AnnotationAssertion( "EHDAA2:0000986") +AnnotationAssertion( "EMAPA:17164") +AnnotationAssertion( "VHOG:0000531") AnnotationAssertion(rdfs:label "lens vesicle cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36599,6 +56994,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (4th arch mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a pharyngeal arch 4.") +AnnotationAssertion( "EHDAA2:0000096") +AnnotationAssertion( "EHDAA:1677") +AnnotationAssertion( "EMAPA:16770") +AnnotationAssertion( "FMA:295702") +AnnotationAssertion( "VHOG:0001052") AnnotationAssertion(rdfs:label "4th arch mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36606,14 +57007,45 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (optic eminence mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a optic eminence.") +AnnotationAssertion( "EHDAA:942") +AnnotationAssertion( "EMAPA:16324") +AnnotationAssertion( "RETIRED_EHDAA2:0001310") +AnnotationAssertion( "VHOG:0001073") AnnotationAssertion(rdfs:label "optic eminence mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (foregut duodenum mesentery) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesentery of duodenum that is part of a foregut.") +AnnotationAssertion( "EHDAA2:0000564") +AnnotationAssertion(rdfs:label "foregut duodenum mesentery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (midgut duodenum mesentery) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesentery of duodenum that is part of a midgut.") +AnnotationAssertion( "EHDAA2:0001193") +AnnotationAssertion(rdfs:label "midgut duodenum mesentery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (hindbrain venous system) +AnnotationAssertion(Annotation( "OBOL:automatic") "A venous system that is part of a hindbrain.") +AnnotationAssertion( "EHDAA2:0000776") +AnnotationAssertion( "EMAPA:18632") +AnnotationAssertion( "VHOG:0001322") AnnotationAssertion(rdfs:label "hindbrain venous system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36622,6 +57054,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (chemosensory system) +AnnotationAssertion( "BILA:0000139") AnnotationAssertion(rdfs:label "chemosensory system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36629,6 +57062,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (extraembryonic mesoderm) +AnnotationAssertion( "EHDAA2:0000474") +AnnotationAssertion( "EMAPA:31862") +AnnotationAssertion( "EMAPA:31863") +AnnotationAssertion( "FMA:296719") +AnnotationAssertion( "VHOG:0000616") AnnotationAssertion(rdfs:label "extraembryonic mesoderm") SubClassOf( ) SubClassOf( ) @@ -36638,6 +57076,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage field) +AnnotationAssertion(Annotation( "OBOL:automatic") "A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme.") +AnnotationAssertion( "TAO:0001453") +AnnotationAssertion( "ZFA:0001453") AnnotationAssertion(rdfs:label "pectoral appendage field") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36646,6 +57087,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (paired limb/fin field) +AnnotationAssertion(Annotation( "ISBN:9780878932504") "A ring of cells capable of forming a limb or paired fin[Gilbert,modified].") AnnotationAssertion(rdfs:label "paired limb/fin field") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36657,6 +57099,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tunica adventitia of blood vessel) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Tunica_externa_(vessels)") "The outermost layer of a blood vessel, composed mainly of fibrous tissue.") +AnnotationAssertion( "BTO:0002010") +AnnotationAssertion( "EMAPA:36299") +AnnotationAssertion( "NCIT:C33818") +AnnotationAssertion( "SCTID:61066005") +AnnotationAssertion( "Wikipedia:Tunica_externa_(vessels)") AnnotationAssertion(rdfs:label "tunica adventitia of blood vessel") SubClassOf( ) SubClassOf( ) @@ -36665,6 +57113,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tunica intima of artery) +AnnotationAssertion(Annotation( "OBOL:automatic") "A tunica intima that is part of a artery.") +AnnotationAssertion( "EMAPA:36293") +AnnotationAssertion( "EV:0100028") +AnnotationAssertion( "FMA:14272") +AnnotationAssertion( "SCTID:40022005") +AnnotationAssertion( "galen:IntimaOfArtery") AnnotationAssertion(rdfs:label "tunica intima of artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36673,13 +57127,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (adventitia) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Adventitia") "An outermost connective tissue covering of an organ, vessel, or other structure[WP].") +AnnotationAssertion( "BTO:0002010") +AnnotationAssertion( "FMA:45635") +AnnotationAssertion( "SCTID:30180000") +AnnotationAssertion( "Wikipedia:Adventitia") AnnotationAssertion(rdfs:label "adventitia") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (bone foramen) +AnnotationAssertion(Annotation( "TAO:curator") "Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves.") +AnnotationAssertion( "AAO:0010438") +AnnotationAssertion( "TAO:0001736") +AnnotationAssertion( "VHOG:0001760") +AnnotationAssertion( "ZFA:0005386") AnnotationAssertion(rdfs:label "bone foramen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36687,9 +57150,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (acellular membrane) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "An acellular anatomical structure that is the bounding layer of a anatomical structure.") +AnnotationAssertion( "FMA:63871") AnnotationAssertion(rdfs:label "acellular membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36697,6 +57159,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (basement membrane of epithelium) +AnnotationAssertion(Annotation( "Wikipedia:Basement_membrane") Annotation( "http://orcid.org/0000-0002-6601-2165") "An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina.") +AnnotationAssertion( "AAO:0010596") +AnnotationAssertion( "FMA:63872") +AnnotationAssertion( "GAID:915") +AnnotationAssertion( "NCIT:C13191") +AnnotationAssertion( "SCTID:68989006") +AnnotationAssertion( "Wikipedia:Basement_membrane") AnnotationAssertion(rdfs:label "basement membrane of epithelium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36707,6 +57176,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (section of aorta) +AnnotationAssertion(Annotation( "ncithesaurus:Aortic_Segment") "Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle.") +AnnotationAssertion( "FMA:13087") +AnnotationAssertion( "NCIT:C34027") +AnnotationAssertion( "SCTID:119203005") AnnotationAssertion(rdfs:label "section of aorta") SubClassOf( ) SubClassOf( ) @@ -36714,6 +57187,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dorsal aorta) +AnnotationAssertion(Annotation( "GO:0035907") Annotation( "https://sourceforge.net/p/geneontology/ontology-requests/8525/") "The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.") +AnnotationAssertion( "AAO:0011029") +AnnotationAssertion( "BTO:0004673") +AnnotationAssertion( "EHDAA:402") +AnnotationAssertion( "EMAPA:18606") +AnnotationAssertion( "SCTID:338637006") +AnnotationAssertion( "TAO:0000014") +AnnotationAssertion( "VHOG:0000264") +AnnotationAssertion( "Wikipedia:Dorsal_aorta") +AnnotationAssertion( "XAO:0000051") +AnnotationAssertion( "ZFA:0000014") AnnotationAssertion(rdfs:label "dorsal aorta") SubClassOf( ) SubClassOf( ) @@ -36721,13 +57205,45 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (portal system) + +AnnotationAssertion(Annotation( "Wikipedia:Portal_venous_system") "In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP].") +AnnotationAssertion( "FMA:45628") +AnnotationAssertion( "MESH:D011168") +AnnotationAssertion( "NCIT:C33344") +AnnotationAssertion( "SCTID:362063001") +AnnotationAssertion( "Wikipedia:Portal_venous_system") +AnnotationAssertion(rdfs:label "portal system") +SubClassOf( ) + # Class: (spinal cord segment) +AnnotationAssertion( "BIRNLEX:2665") +AnnotationAssertion( "FMA:62420") +AnnotationAssertion( "MA:0003080") +AnnotationAssertion( "SCTID:278748001") AnnotationAssertion(rdfs:label "spinal cord segment") SubClassOf( ) +# Class: (caudal segment of spinal cord) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A spinal cord segment that adjacent_to a caudal region.") +AnnotationAssertion( "FMA:256635") +AnnotationAssertion( "MA:0003084") +AnnotationAssertion( "SCTID:278753006") +AnnotationAssertion( "neuronames:1656") +AnnotationAssertion(rdfs:comment "for spinal cord segments, we treat coccygeal/caudal as synonyms - we only differentiate where bone is concerned") +AnnotationAssertion(rdfs:label "caudal segment of spinal cord") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (developing mesenchymal condensation) +AnnotationAssertion(Annotation( "AEO:0000148") "A delimited region of dense mesenchyme within looser mesenchyme.") +AnnotationAssertion( "AEO:0000148") +AnnotationAssertion( "EHDAA2_RETIRED:0003148") +AnnotationAssertion( "EHDAA:8979") AnnotationAssertion(rdfs:label "developing mesenchymal condensation") SubClassOf( ) SubClassOf( ) @@ -36735,6 +57251,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cartilaginous condensation) +AnnotationAssertion(Annotation( "GO:curator") "Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes.") +AnnotationAssertion( "AEO:0000147") +AnnotationAssertion( "EHDAA2_RETIRED:0003147") +AnnotationAssertion( "EMAPA:32731") +AnnotationAssertion( "VSAO:0000092") +AnnotationAssertion( "XAO:0004022") AnnotationAssertion(rdfs:label "cartilaginous condensation") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36742,6 +57264,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pre-muscle condensation) +AnnotationAssertion( "AEO:0000149") +AnnotationAssertion( "EHDAA2_RETIRED:0003149") AnnotationAssertion(rdfs:label "pre-muscle condensation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36751,6 +57275,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pre-cartilage condensation) +AnnotationAssertion(Annotation( "AEO:0000150") Annotation( "AEO:JB") "A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts.") +AnnotationAssertion( "AEO:0000150") +AnnotationAssertion( "EHDAA2:0003150") +AnnotationAssertion( "EMAPA:32736") AnnotationAssertion(rdfs:label "pre-cartilage condensation") SubClassOf( ) SubClassOf( ) @@ -36759,19 +57287,53 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mandibular prominence) +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0010939") "The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip.") +AnnotationAssertion( "EHDAA2:0001061") +AnnotationAssertion( "EHDAA:5871") +AnnotationAssertion( "EMAPA:17355") +AnnotationAssertion( "FMA:293051") +AnnotationAssertion( "NCIT:C34204") +AnnotationAssertion( "Wikipedia:Mandibular_prominence") AnnotationAssertion(rdfs:label "mandibular prominence") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (maxillary prominence) + +AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0010940") "The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw.") +AnnotationAssertion( "EHDAA2:0001070") +AnnotationAssertion( "EHDAA:5877") +AnnotationAssertion( "EMAPA:17359") +AnnotationAssertion( "FMA:293049") +AnnotationAssertion( "NCIT:C34206") +AnnotationAssertion( "SCTID:346355001") +AnnotationAssertion( "Wikipedia:Maxillary_prominence") +AnnotationAssertion(rdfs:label "maxillary prominence") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (occipital region) +AnnotationAssertion(Annotation( "TAO:0001414") Annotation( "UBERONREF:0000007") "Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles.") +AnnotationAssertion( "AAO:0010199") +AnnotationAssertion( "BTO:0004675") +AnnotationAssertion( "FMA:49187") +AnnotationAssertion( "SCTID:362618001") +AnnotationAssertion( "TAO:0001414") +AnnotationAssertion( "XAO:0003173") +AnnotationAssertion( "ZFA:0001414") +AnnotationAssertion( "neuronames:2431") AnnotationAssertion(rdfs:label "occipital region") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (serous sac) +AnnotationAssertion(Annotation( "FMA:9689") Annotation( "https://github.com/obophenotype/uberon/issues/86") "Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA].") +AnnotationAssertion( "FMA:9689") +AnnotationAssertion( "SCTID:362890006") +AnnotationAssertion(rdfs:comment "See notes for serous membrane") AnnotationAssertion(rdfs:label "serous sac") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36779,6 +57341,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endo-epithelium) +AnnotationAssertion(Annotation( "FMA:69065") "Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA].") +AnnotationAssertion( "FMA:69065") AnnotationAssertion(rdfs:label "endo-epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36786,15 +57350,35 @@ SubClassOf( (axial skeleton plus cranial skeleton) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FMA:71221") Annotation( "VSAO:0000056") Annotation( "Wikipedia:Axial_skeleton") Annotation( "https://github.com/obophenotype/uberon/issues/44") Annotation( "https://github.com/obophenotype/uberon/wiki/The-axial-skeleton") "Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified].") +AnnotationAssertion( "AAO:0000963") +AnnotationAssertion( "EMAPA:17214") +AnnotationAssertion( "MA:0000308") +AnnotationAssertion( "NCIT:C32172") +AnnotationAssertion( "SCTID:361725000") +AnnotationAssertion( "VSAO:0000056") +AnnotationAssertion( "Wikipedia:Axial_skeleton") +AnnotationAssertion( "XAO:0004011") AnnotationAssertion(rdfs:label "axial skeleton plus cranial skeleton") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (neurocranial trabecula) + +AnnotationAssertion( "EFO:0003677") +AnnotationAssertion( "TAO:0001321") +AnnotationAssertion( "ZFA:0001321") +AnnotationAssertion(rdfs:label "neurocranial trabecula") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (outflow tract of atrium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An outflow tract that is part of a cardiac atrium.") +AnnotationAssertion( "FMA:14141") AnnotationAssertion(rdfs:label "outflow tract of atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36803,6 +57387,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow part of right ventricle) +AnnotationAssertion(Annotation( "MP:0010428") "Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk.") +AnnotationAssertion( "FMA:7216") +AnnotationAssertion( "NCIT:C61368") +AnnotationAssertion( "SCTID:244379003") AnnotationAssertion(rdfs:label "outflow part of right ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36812,6 +57400,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow part of left ventricle) +AnnotationAssertion(Annotation( "MP:0010429") "Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta.") +AnnotationAssertion( "FMA:9473") +AnnotationAssertion( "SCTID:264070001") +AnnotationAssertion( "Wikipedia:Aortic_vestibule") AnnotationAssertion(rdfs:label "outflow part of left ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36819,6 +57411,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow part of right atrium) +AnnotationAssertion(Annotation( "FMA:9550") Annotation( "FMA:FMA") "Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA].") +AnnotationAssertion( "FMA:9550") AnnotationAssertion(rdfs:label "outflow part of right atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36826,6 +57420,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (outflow part of left atrium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An outflow tract of atrium that is part of a left atrium.") +AnnotationAssertion( "FMA:9551") AnnotationAssertion(rdfs:label "outflow part of left atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36833,6 +57429,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (crista terminalis) +AnnotationAssertion(Annotation( "MP:0010495") "The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium.") +AnnotationAssertion( "FMA:9236") +AnnotationAssertion( "SCTID:277693004") +AnnotationAssertion( "Wikipedia:Crista_terminalis") AnnotationAssertion(rdfs:label "crista terminalis") SubClassOf( ) SubClassOf( ) @@ -36841,6 +57441,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart layer) +AnnotationAssertion(Annotation( "MP:0010545") "The laminar structure of the heart.") AnnotationAssertion(rdfs:label "heart layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36850,6 +57451,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (coronary vessel) +AnnotationAssertion(Annotation( "MP:0010551") "Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation.") +AnnotationAssertion( "MESH:D003331") +AnnotationAssertion( "Wikipedia:Coronary_circulation") AnnotationAssertion(rdfs:label "coronary vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36857,8 +57461,24 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (atrium myocardial trabecula) + +AnnotationAssertion(Annotation( "MP:0010581") Annotation( "ZFA:0005810") "The supporting bundles of muscular fibers lining the walls of the atrial myocardium.") +AnnotationAssertion( "ZFA:0005810") +AnnotationAssertion(rdfs:label "atrium myocardial trabecula") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (atrioventricular septum) +AnnotationAssertion(Annotation( "MP:0010592") "The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve.") +AnnotationAssertion( "FMA:7136") +AnnotationAssertion( "SCTID:280151006") +AnnotationAssertion( "Wikipedia:Atrioventricular_septum") AnnotationAssertion(rdfs:label "atrioventricular septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36869,6 +57489,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vitelline artery) +AnnotationAssertion(Annotation( "MP:0010664") Annotation( "Wikipedia:Vitelline_arteries") "The paired arteries that carry blood to the yolk sac from the dorsal aorta.") +AnnotationAssertion( "EHDAA2:0002208") +AnnotationAssertion( "EMAPA:16207") +AnnotationAssertion( "Wikipedia:Vitelline_arteries") +AnnotationAssertion(rdfs:comment "Development notes:; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult[MP:0010664]") AnnotationAssertion(rdfs:label "vitelline artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36878,6 +57503,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (integumentary adnexa) +AnnotationAssertion(Annotation( "http://code.google.com/p/caro2/issues/detail?id=5") Annotation( "http://orcid.org/0000-0002-6601-2165") "Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers.") +AnnotationAssertion( "Wikipedia:Skin_appendage") AnnotationAssertion(rdfs:label "integumentary adnexa") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36890,8 +57517,95 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (bone of tail) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of a post-anal tail.") +AnnotationAssertion( "EMAPA:18042") +AnnotationAssertion( "MA:0000696") +AnnotationAssertion(rdfs:label "bone of tail") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (caudal region) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this.") +AnnotationAssertion( "XAO:0000087") +AnnotationAssertion(rdfs:label "caudal region") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (cervical region of vertebral column) + +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/") "That portion of the spine comprising the cervical vertebrae. The neck area of the spine.") +AnnotationAssertion( "AAO:0000092") +AnnotationAssertion( "BTO:0004148") +AnnotationAssertion( "EHDAA2:0000238") +AnnotationAssertion( "EHDAA:5051") +AnnotationAssertion( "EMAPA:17215") +AnnotationAssertion( "FMA:24138") +AnnotationAssertion( "MA:0003154") +AnnotationAssertion( "NCIT:C69313") +AnnotationAssertion( "SCTID:260488005") +AnnotationAssertion(rdfs:label "cervical region of vertebral column") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (thoracic region of vertebral column) + +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/") "That part of the spine comprising the thoracic vertebrae.") +AnnotationAssertion( "BTO:0004150") +AnnotationAssertion( "EHDAA:5063") +AnnotationAssertion( "EMAPA:17396") +AnnotationAssertion( "FMA:9140") +AnnotationAssertion( "MA:0003155") +AnnotationAssertion( "NCIT:C69315") +AnnotationAssertion( "SCTID:243931006") +AnnotationAssertion(rdfs:label "thoracic region of vertebral column") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (caudal region of vertebral column) + +AnnotationAssertion(Annotation( "UBERONREF:0000006") "Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae.") +AnnotationAssertion( "AAO:0000082") +AnnotationAssertion( "EMAPA:18043") +AnnotationAssertion( "MA:0003158") +AnnotationAssertion(rdfs:label "caudal region of vertebral column") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (subdivision of vertebral column) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A collection of all skeletal elements in some subdivision of the vertebral column.") +AnnotationAssertion( "FMA:16201") +AnnotationAssertion(rdfs:label "subdivision of vertebral column") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (aortico-pulmonary spiral septum) +AnnotationAssertion(Annotation( "MP:0010650") Annotation( "Wikipedia:Aorticopulmonary_septum") "The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions.") +AnnotationAssertion( "CALOHA:TS-2409") +AnnotationAssertion( "EHDAA2:0000136") +AnnotationAssertion( "EHDAA:2592") +AnnotationAssertion( "EMAPA:16827") +AnnotationAssertion( "VHOG:0000502") +AnnotationAssertion( "Wikipedia:Aorticopulmonary_septum") AnnotationAssertion(rdfs:label "aortico-pulmonary spiral septum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36902,6 +57616,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (buccopharyngeal membrane) +AnnotationAssertion(Annotation( "MP:0012521") "The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx.") +AnnotationAssertion( "EHDAA2:0000189") +AnnotationAssertion( "EHDAA:536") +AnnotationAssertion( "EMAPA:16259") +AnnotationAssertion( "FMA:313607") +AnnotationAssertion( "SCTID:361412007") +AnnotationAssertion( "VHOG:0000380") +AnnotationAssertion( "Wikipedia:Buccopharyngeal_membrane") AnnotationAssertion(rdfs:label "buccopharyngeal membrane") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36913,12 +57635,65 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (common atrial chamber) +AnnotationAssertion( "EHDAA:1267") +AnnotationAssertion( "EMAPA:16342") +AnnotationAssertion( "RETIRED_EHDAA2:0000268") AnnotationAssertion(rdfs:label "common atrial chamber") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (ethmoid bone primordium) + +AnnotationAssertion( "EHDAA2:0000456") +AnnotationAssertion( "EHDAA:8363") +AnnotationAssertion( "EMAPA:18023") +AnnotationAssertion( "FMA:312597") +AnnotationAssertion(rdfs:label "ethmoid bone primordium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (foregut-midgut junction) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical junctions that overlaps the foregut and midgut.") +AnnotationAssertion( "EHDAA2:0000569") +AnnotationAssertion( "EHDAA:526") +AnnotationAssertion( "EMAPA:16363") +AnnotationAssertion( "VHOG:0000291") +AnnotationAssertion(rdfs:label "foregut-midgut junction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (tetrapod frontal bone primordium) + +AnnotationAssertion( "EHDAA2:0000577") +AnnotationAssertion( "EHDAA:9540") +AnnotationAssertion( "EMAPA:18017") +AnnotationAssertion( "FMA:312589") +AnnotationAssertion(rdfs:label "tetrapod frontal bone primordium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (future brain) +AnnotationAssertion(Annotation( "NLX:94995") "The embryonic precursor of the brain.") +AnnotationAssertion( "BAMS:Enc") +AnnotationAssertion( "BTO:0004726") +AnnotationAssertion( "EFO:0003431") +AnnotationAssertion( "EHDAA:300") +AnnotationAssertion( "EHDAA:830") +AnnotationAssertion( "EMAPA:16089") +AnnotationAssertion( "FMA:312967") +AnnotationAssertion( "RETIRED_EHDAA2:0000591") +AnnotationAssertion( "TAO:0000146") +AnnotationAssertion( "ZFA:0000146") AnnotationAssertion(rdfs:label "future brain") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36926,6 +57701,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future central tendon) +AnnotationAssertion(Annotation( "OBOL:automatic") "A tendon that has the potential to develop into a central tendon.") +AnnotationAssertion( "EHDAA2:0000593") +AnnotationAssertion( "EHDAA:4118") +AnnotationAssertion( "EMAPA:25035") AnnotationAssertion(rdfs:label "future central tendon") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36937,14 +57716,41 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future spinal cord) +AnnotationAssertion( "EFO:0003438") +AnnotationAssertion( "EHDAA2:0000674") +AnnotationAssertion( "EHDAA:898") +AnnotationAssertion( "EMAPA:16092") +AnnotationAssertion( "EMAPA:16755") +AnnotationAssertion( "TAO:0000417") +AnnotationAssertion( "ZFA:0000417") AnnotationAssertion(rdfs:label "future spinal cord") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (gallbladder primordium) + +AnnotationAssertion(Annotation( "ISBN:0815318960") Annotation( "XAO:0004205") "A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops.") +AnnotationAssertion( "EHDAA2:0000700") +AnnotationAssertion( "EHDAA:3047") +AnnotationAssertion( "EMAPA:16713") +AnnotationAssertion( "XAO:0004205") +AnnotationAssertion(rdfs:label "gallbladder primordium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mouth-foregut junction) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical junctions that overlaps the mouth and foregut.") +AnnotationAssertion( "EHDAA:534") +AnnotationAssertion( "EMAPA:16258") +AnnotationAssertion( "RETIRED_EHDAA2:0001205") +AnnotationAssertion( "VHOG:0000592") AnnotationAssertion(rdfs:label "mouth-foregut junction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36954,6 +57760,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (notochordal plate) +AnnotationAssertion(Annotation( "VHOG:0001212") "The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.") +AnnotationAssertion( "EHDAA2:0001278") +AnnotationAssertion( "EHDAA:264") +AnnotationAssertion( "EMAPA:16101") +AnnotationAssertion( "NCIT:C34231") +AnnotationAssertion( "VHOG:0001212") AnnotationAssertion(rdfs:label "notochordal plate") SubClassOf( ) SubClassOf( ) @@ -36963,13 +57775,40 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (notochordal process) +AnnotationAssertion(Annotation( "http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/05embryonicperiod.htm") "A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.") +AnnotationAssertion( "EHDAA2:0001279") +AnnotationAssertion( "EHDAA:224") +AnnotationAssertion( "EMAPA:16102") +AnnotationAssertion( "FMA:293135") +AnnotationAssertion( "NCIT:C34232") +AnnotationAssertion( "VHOG:0001213") +AnnotationAssertion(rdfs:comment "The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.") AnnotationAssertion(rdfs:label "notochordal process") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (orbital fissure) + +AnnotationAssertion(Annotation( "http://www.merriam-webster.com/medical/orbital%20fissure") "Either of two openings transmitting nerves and blood vessels to or from the orbit.") +AnnotationAssertion( "EHDAA2:0001328") +AnnotationAssertion( "EHDAA:10648") +AnnotationAssertion( "EMAPA:18717") +AnnotationAssertion( "SCTID:280546005") +AnnotationAssertion(rdfs:label "orbital fissure") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (pleuroperitoneal canal) +AnnotationAssertion(Annotation( "ISBN:0124020607") Annotation( "VHOG:0001505") "Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity.") +AnnotationAssertion( "EHDAA2:0001481") +AnnotationAssertion( "EHDAA:4128") +AnnotationAssertion( "EMAPA:17707") +AnnotationAssertion( "SCTID:361413002") +AnnotationAssertion( "VHOG:0001505") AnnotationAssertion(rdfs:label "pleuroperitoneal canal") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -36981,14 +57820,44 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future cardiac ventricle) +AnnotationAssertion(Annotation( "ZFA:0001719") "Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle.") +AnnotationAssertion( "EHDAA2:0001531") +AnnotationAssertion( "EMAPA:16350") +AnnotationAssertion( "FMA:71006") +AnnotationAssertion( "NCIT:C34160") +AnnotationAssertion( "SCTID:361524003") +AnnotationAssertion( "TAO:0002231") +AnnotationAssertion( "Wikipedia:Embryonic_ventricle") +AnnotationAssertion( "ZFA:0001719") +AnnotationAssertion(rdfs:comment "The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum[WP]") AnnotationAssertion(rdfs:label "future cardiac ventricle") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (spleen primordium) + +AnnotationAssertion(Annotation( "ISBN:0123747295") Annotation( "MP:0011263") "A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP].") +AnnotationAssertion( "EHDAA2:0001904") +AnnotationAssertion( "EHDAA:3003") +AnnotationAssertion( "EMAPA:18535") +AnnotationAssertion( "XAO:0000326") +AnnotationAssertion(rdfs:label "spleen primordium") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (future trigeminal ganglion) +AnnotationAssertion( "EHDAA:924") +AnnotationAssertion( "EMAPA:16663") +AnnotationAssertion( "RETIRED_EHDAA2:0002089") +AnnotationAssertion(rdfs:comment "See: https://github.com/obophenotype/mouse-anatomy-ontology/issues/13 and https://github.com/obophenotype/uberon/issues/693 -- consider merging into trigeminal ganglion, as this complicates the model") AnnotationAssertion(rdfs:label "future trigeminal ganglion") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -36997,6 +57866,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (chamber of eyeball) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A segment of the eyeball that is filled with refractive media.") +AnnotationAssertion( "BTO:0002085") +AnnotationAssertion( "FMA:58071") +AnnotationAssertion( "MA:0002459") +AnnotationAssertion( "NCIT:C32301") +AnnotationAssertion( "SCTID:280540004") AnnotationAssertion(rdfs:label "chamber of eyeball") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37006,12 +57881,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ocular refractive media) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Body substance in a liquid or semi-solid state in the eyeball which serves to refract light.") +AnnotationAssertion( "MA:0001911") AnnotationAssertion(rdfs:label "ocular refractive media") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (bodily fluid) +AnnotationAssertion(Annotation( "MESH:A12.207") Annotation( "Wikipedia:Body_fluid") "Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.") +AnnotationAssertion( "BIRNLEX:20") +AnnotationAssertion( "FMA:280556") +AnnotationAssertion( "GAID:266") +AnnotationAssertion( "MESH:D001826") +AnnotationAssertion( "Wikipedia:Body_fluid") +AnnotationAssertion( "galen:BodyFluid") AnnotationAssertion(rdfs:label "bodily fluid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37019,6 +57903,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (brainstem nucleus) +AnnotationAssertion(Annotation( "OBOL:automatic") "A nucleus of brain that is part of a brainstem.") +AnnotationAssertion( "EMAPA:32790") +AnnotationAssertion( "MA:0000821") AnnotationAssertion(rdfs:label "brainstem nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37026,6 +57913,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (communicating artery) +AnnotationAssertion(Annotation( "ncithesaurus:Communicating_Artery") "An artery that connects two larger arteries.") +AnnotationAssertion( "EMAPA:18598") +AnnotationAssertion( "MA:0001938") +AnnotationAssertion( "NCIT:C52851") +AnnotationAssertion(rdfs:comment "Grouping for anterior and posterior") AnnotationAssertion(rdfs:label "communicating artery") EquivalentClasses( ObjectIntersectionOf( ObjectExactCardinality(2 ))) SubClassOf( ) @@ -37033,6 +57925,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right lung lobe) +AnnotationAssertion(Annotation( "OBOL:automatic") "A lobe of lung that is part of a right lung.") +AnnotationAssertion( "EMAPA:35155") +AnnotationAssertion( "MA:0001791") +AnnotationAssertion( "NCIT:C48944") +AnnotationAssertion( "SCTID:272654004") AnnotationAssertion(rdfs:label "right lung lobe") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37040,6 +57937,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (alveolar system) +AnnotationAssertion(Annotation( "BTO:0000136") "System pertaining to a bronchus and alveoli.") +AnnotationAssertion( "BTO:0000136") +AnnotationAssertion( "CALOHA:TS-1296") +AnnotationAssertion( "EMAPA:32692") +AnnotationAssertion( "MA:0000416") AnnotationAssertion(rdfs:label "alveolar system") SubClassOf( ) SubClassOf( ) @@ -37048,6 +57950,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left lung alveolar system) +AnnotationAssertion( "EMAPA:19001") +AnnotationAssertion( "MA:0001775") AnnotationAssertion(rdfs:label "left lung alveolar system") SubClassOf( ) SubClassOf( ) @@ -37056,6 +57960,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right lung alveolar system) +AnnotationAssertion( "EMAPA:35717") +AnnotationAssertion( "MA:0001784") AnnotationAssertion(rdfs:label "right lung alveolar system") SubClassOf( ) SubClassOf( ) @@ -37064,6 +57970,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin secretion) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of organism substance that secreted_by a zone of skin.") +AnnotationAssertion( "MA:0002537") AnnotationAssertion(rdfs:label "skin secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37071,6 +57979,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (female reproductive gland secretion) +AnnotationAssertion(Annotation( "UBERON:cjm") "A portion of organism substance that is secreted by a female reproductive gland.") +AnnotationAssertion( "MA:0002510") AnnotationAssertion(rdfs:label "female reproductive gland secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37078,19 +57988,37 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system fluid/secretion) +AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of organism substance that secreted_by a respiratory system.") +AnnotationAssertion( "EMAPA:36550") +AnnotationAssertion( "MA:0002533") +AnnotationAssertion( "NCIT:C13722") AnnotationAssertion(rdfs:label "respiratory system fluid/secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (excretory tube) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A tube that is part of a excretory system.") +AnnotationAssertion(rdfs:label "excretory tube") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (pharynx) +AnnotationAssertion(Annotation( "GO:0060465") "The pharynx is the part of the digestive system immediately posterior to the mouth[GO].") +AnnotationAssertion( "MAT:0000049") +AnnotationAssertion( "MESH:D010614") +AnnotationAssertion( "MIAA:0000049") AnnotationAssertion(rdfs:label "pharynx") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (tunica media of pulmonary trunk) +AnnotationAssertion(Annotation( "FMA:85030") Annotation( "FMA:FMA") "Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA].") +AnnotationAssertion( "FMA:85030") AnnotationAssertion(rdfs:label "tunica media of pulmonary trunk") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37098,7 +58026,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left ventricle myocardium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A myocardium that is part of a left ventricle of a heart.") +AnnotationAssertion( "FMA:9558") +AnnotationAssertion( "MA:0002983") +AnnotationAssertion( "SCTID:362021000") AnnotationAssertion(rdfs:label "left ventricle myocardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37107,15 +58038,59 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right ventricle myocardium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A myocardium that is part of a right ventricle of a heart.") +AnnotationAssertion( "FMA:9535") +AnnotationAssertion( "MA:0002984") +AnnotationAssertion( "SCTID:362020004") AnnotationAssertion(rdfs:label "right ventricle myocardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (trabecula carnea of right ventricle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A trabecula carnea that is part of a heart right ventricle.") +AnnotationAssertion( "FMA:7270") +AnnotationAssertion( "SCTID:192373001") +AnnotationAssertion(rdfs:label "trabecula carnea of right ventricle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (trabecula carnea of left ventricle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A trabecula carnea that is part of a heart left ventricle.") +AnnotationAssertion( "FMA:7271") +AnnotationAssertion( "SCTID:190344008") +AnnotationAssertion(rdfs:label "trabecula carnea of left ventricle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pectinate line) + +AnnotationAssertion(Annotation( "Wikipedia:Pectinate_line") "The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:.") +AnnotationAssertion( "EMAPA:19159") +AnnotationAssertion( "FMA:75383") +AnnotationAssertion( "NCIT:C34245") +AnnotationAssertion( "SCTID:245445008") +AnnotationAssertion( "Wikipedia:Pectinate_line") +AnnotationAssertion(rdfs:label "pectinate line") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (presumptive endoderm) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Presumptive structure of the blastula that will develop into endoderm.") +AnnotationAssertion( "AAO:0000471") +AnnotationAssertion( "EFO:0003437") +AnnotationAssertion( "TAO:0000416") +AnnotationAssertion( "ZFA:0000416") AnnotationAssertion(rdfs:label "presumptive endoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37125,6 +58100,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive blood) +AnnotationAssertion( "AAO:0000468") +AnnotationAssertion( "EFO:0003439") +AnnotationAssertion( "TAO:0000568") +AnnotationAssertion( "ZFA:0000568") AnnotationAssertion(rdfs:label "presumptive blood") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37132,6 +58111,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive structure) +AnnotationAssertion(Annotation( "GOC:CVS") Annotation( "GOC:YMB") Annotation( "ZFA:0001116") "Portion of embryonic tissue determined by fate mapping to become a structure.") +AnnotationAssertion( "AAO:0000479") +AnnotationAssertion( "TAO:0001116") +AnnotationAssertion( "ZFA:0001116") AnnotationAssertion(rdfs:label "presumptive structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37139,6 +58122,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive ectoderm) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Presumptive structure of the blastula that will develop into ectoderm.") +AnnotationAssertion( "AAO:0000470") +AnnotationAssertion( "EFO:0003466") +AnnotationAssertion( "TAO:0001376") +AnnotationAssertion( "XAO:0004132") +AnnotationAssertion( "ZFA:0001376") AnnotationAssertion(rdfs:label "presumptive ectoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37148,6 +58137,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive mesoderm) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Presumptive structure of the blastula that will develop into mesoderm.") +AnnotationAssertion( "AAO:0000476") +AnnotationAssertion( "EFO:0003467") +AnnotationAssertion( "TAO:0001377") +AnnotationAssertion( "ZFA:0001377") AnnotationAssertion(rdfs:label "presumptive mesoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37155,8 +58149,26 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (muscular coat) + +AnnotationAssertion(Annotation( "Wikipedia:Muscular_layer") "A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis.") +AnnotationAssertion( "BTO:0004838") +AnnotationAssertion( "SCTID:86915006") +AnnotationAssertion( "Wikipedia:Muscular_layer") +AnnotationAssertion(rdfs:label "muscular coat") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (central tendon of diaphragm) +AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0012061") "The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers.") +AnnotationAssertion( "EMAPA:17702") +AnnotationAssertion( "FMA:58279") +AnnotationAssertion( "NCIT:C34119") +AnnotationAssertion( "SCTID:244943002") +AnnotationAssertion( "VHOG:0001399") +AnnotationAssertion( "Wikipedia:Central_tendon_of_diaphragm") AnnotationAssertion(rdfs:label "central tendon of diaphragm") SubClassOf( ) SubClassOf( ) @@ -37167,14 +58179,37 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (surface of epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical boundary that adjacent_to a epithelium.") +AnnotationAssertion( "FMA:70997") AnnotationAssertion(rdfs:label "surface of epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (spinal vein) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A vein that is part of a vertebral column.") +AnnotationAssertion( "EMAPA:18255") +AnnotationAssertion( "FMA:76735") +AnnotationAssertion( "MA:0002108") +AnnotationAssertion( "SCTID:181376008") +AnnotationAssertion( "Wikipedia:Spinal_veins") +AnnotationAssertion(rdfs:label "spinal vein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (corneo-scleral junction) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MP:0013477") "The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm.") +AnnotationAssertion( "EFO:0001403") +AnnotationAssertion( "FMA:58342") +AnnotationAssertion( "GAID:896") +AnnotationAssertion( "MESH:D016850") +AnnotationAssertion( "SCTID:63716004") +AnnotationAssertion( "Wikipedia:Corneal_limbus") +AnnotationAssertion( "ZFA:0005570") +AnnotationAssertion(rdfs:comment "This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343") AnnotationAssertion(rdfs:label "corneo-scleral junction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37185,6 +58220,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (glandular epithelium) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An epithelium that is composed primarily of secretory cells.") +AnnotationAssertion( "BTO:0002991") +AnnotationAssertion( "NCIT:C43370") +AnnotationAssertion( "NCIT:C45715") AnnotationAssertion(rdfs:label "glandular epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37192,14 +58231,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (areolar connective tissue) +AnnotationAssertion(Annotation( "FMA:63897") "Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand.") +AnnotationAssertion( "AAO:0000027") +AnnotationAssertion( "FMA:63897") +AnnotationAssertion( "SCTID:68477002") AnnotationAssertion(rdfs:label "areolar connective tissue") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (trabecula carnea of atrium) + +AnnotationAssertion(Annotation( "MP:0010581") "The supporting bundles of muscular fibers lining the walls of the atria[MP].") +AnnotationAssertion(rdfs:label "trabecula carnea of atrium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (lumen of trachea) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that surrounded_by a trachea.") +AnnotationAssertion( "FMA:7469") +AnnotationAssertion( "SCTID:197486000") AnnotationAssertion(rdfs:label "lumen of trachea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37208,6 +58262,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (uterus or analog) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A subdivision of a the reproductive tract in a female organism that is the site of embryo development.") +AnnotationAssertion( "TADS:0000421") +AnnotationAssertion( "WBbt:0006760") AnnotationAssertion(rdfs:label "uterus or analog") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37216,21 +58273,75 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (central vein of liver) + +AnnotationAssertion(Annotation( "ZFA:0005168") "Vein that is central to a lobule in the liver.") +AnnotationAssertion( "FMA:17544") +AnnotationAssertion( "NCIT:C32281") +AnnotationAssertion( "SCTID:272023004") +AnnotationAssertion( "TAO:0005168") +AnnotationAssertion( "Wikipedia:Central_veins_of_liver") +AnnotationAssertion( "ZFA:0005168") +AnnotationAssertion(rdfs:label "central vein of liver") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (surface groove) +AnnotationAssertion(Annotation( "AEO:0000161") Annotation( "AEO:JB") Annotation( "https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/4") "A furrow or an incomplete tube.") +AnnotationAssertion( "AEO:0000161") +AnnotationAssertion( "EHDAA2_RETIRED:0003161") +AnnotationAssertion(rdfs:comment "Surface groove is modelled as immaterial - see https://github.com/obophenotype/uberon/issues/2667 for discussion") AnnotationAssertion(rdfs:label "surface groove") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (terminal part of digestive tract) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus.") +AnnotationAssertion( "WBbt:0005773") +AnnotationAssertion(rdfs:label "terminal part of digestive tract") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vasculature of organ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vasculature that is part of a organ.") +AnnotationAssertion( "FMA:74612") AnnotationAssertion(rdfs:label "vasculature of organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (vasculature of liver) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A vasculature that is part of a liver.") +AnnotationAssertion( "EHDAA2:0003454") +AnnotationAssertion( "EMAPA:35501") +AnnotationAssertion( "FMA:73748") +AnnotationAssertion(rdfs:label "vasculature of liver") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (head mesenchyme from mesoderm) +AnnotationAssertion(Annotation( "OBOL:automatic") "A head mesenchyme that develops_from a mesoderm.") +AnnotationAssertion( "AAO:0011051") +AnnotationAssertion( "EFO:0003337") +AnnotationAssertion( "EFO:0003603") +AnnotationAssertion( "EHDAA2:0001118") +AnnotationAssertion( "EHDAA:655") +AnnotationAssertion( "EMAPA:16099") +AnnotationAssertion( "EMAPA_RETIRED:16270") +AnnotationAssertion( "FMA:293859") +AnnotationAssertion( "TAO:0000998") +AnnotationAssertion( "VHOG:0000185") +AnnotationAssertion( "XAO:0000053") +AnnotationAssertion( "ZFA:0000998") AnnotationAssertion(rdfs:label "head mesenchyme from mesoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37239,6 +58350,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mandibular process mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a mandibular prominence.") +AnnotationAssertion( "EHDAA2:0001062") +AnnotationAssertion( "EHDAA:5861") +AnnotationAssertion( "EHDAA:5873") +AnnotationAssertion( "EMAPA:17357") AnnotationAssertion(rdfs:label "mandibular process mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37246,6 +58362,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lumen of digestive tract) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that surrounded_by a digestive tract.") +AnnotationAssertion( "BTO:0000349") +AnnotationAssertion( "EMAPA:32908") +AnnotationAssertion( "FMA:45677") AnnotationAssertion(rdfs:label "lumen of digestive tract") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37254,6 +58374,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lip epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a lip.") +AnnotationAssertion( "BTO:0004468") +AnnotationAssertion( "TAO:0005334") +AnnotationAssertion( "ZFA:0005334") AnnotationAssertion(rdfs:label "lip epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37261,6 +58385,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (squamous epithelium) +AnnotationAssertion(Annotation( "Wikipedia:Squamous_epithelium") "An epithelium characterised by its most superficial layer consisting of squamous epithelial cells.") +AnnotationAssertion( "BTO:0002072") +AnnotationAssertion( "NCIT:C12848") +AnnotationAssertion( "SCTID:40118003") +AnnotationAssertion( "Wikipedia:Squamous_epithelium") AnnotationAssertion(rdfs:label "squamous epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37268,6 +58397,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (stratified squamous epithelium) +AnnotationAssertion(Annotation( "FMA:45563") Annotation( "Wikipedia:Stratified_squamous_epithelium") "Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA].") +AnnotationAssertion( "FMA:45563") +AnnotationAssertion( "NCIT:C13180") +AnnotationAssertion( "Wikipedia:Stratified_squamous_epithelium") AnnotationAssertion(rdfs:label "stratified squamous epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37275,6 +58408,12 @@ SubClassOf( (esophagus squamous epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A squamous epithelium that is part of a esophagus.") +AnnotationAssertion( "BTO:0003635") +AnnotationAssertion( "CALOHA:TS-1250") +AnnotationAssertion( "EMAPA:35324") +AnnotationAssertion( "MA:0001567") +AnnotationAssertion( "NCIT:C49222") AnnotationAssertion(rdfs:label "esophagus squamous epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37282,6 +58421,9 @@ SubClassOf( (stomach squamous epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A squamous epithelium that is part of a stomach.") +AnnotationAssertion( "EMAPA:35824") +AnnotationAssertion( "MA:0001611") AnnotationAssertion(rdfs:label "stomach squamous epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37289,6 +58431,10 @@ SubClassOf( (stomach glandular epithelium) +AnnotationAssertion(Annotation( "ISBN:0073040584") "A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands.") +AnnotationAssertion( "EMAPA:35814") +AnnotationAssertion( "FMA:63458") +AnnotationAssertion( "MA:0002784") AnnotationAssertion(rdfs:label "stomach glandular epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37298,6 +58444,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (digestive system gland) +AnnotationAssertion(Annotation( "UBERON:cjm") "Any gland that is part of the digestive system.") +AnnotationAssertion( "AAO:0000130") +AnnotationAssertion( "BTO:0000345") AnnotationAssertion(rdfs:label "digestive system gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37305,6 +58454,9 @@ SubClassOf( (glandular columnar epithelium) +AnnotationAssertion(Annotation( "FMA:64800") "Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA].") +AnnotationAssertion( "FMA:64800") +AnnotationAssertion( "NCIT:C13182") AnnotationAssertion(rdfs:label "glandular columnar epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37312,6 +58464,7 @@ SubClassOf( (glandular cuboidal epithelium) +AnnotationAssertion( "FMA:66809") AnnotationAssertion(rdfs:label "glandular cuboidal epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37319,6 +58472,9 @@ SubClassOf( (stomach glandular region mucosa) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region.") +AnnotationAssertion( "EMAPA:27167") +AnnotationAssertion( "MA:0001614") AnnotationAssertion(rdfs:label "stomach glandular region mucosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37326,6 +58482,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sensory epithelium) +AnnotationAssertion(Annotation( "BTO:0000314") "Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue.") +AnnotationAssertion( "CALOHA:TS-0682") +AnnotationAssertion( "FMA:62410") +AnnotationAssertion( "SCTID:309045006") AnnotationAssertion(rdfs:label "sensory epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37334,7 +58494,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ovary stroma) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Stroma_of_ovary") "The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis.") +AnnotationAssertion( "CALOHA:TS-1246") +AnnotationAssertion( "EMAPA:28880") +AnnotationAssertion( "FMA:18626") +AnnotationAssertion( "MA:0002991") +AnnotationAssertion( "NCIT:C33638") +AnnotationAssertion( "SCTID:259306002") +AnnotationAssertion( "Wikipedia:Stroma_of_ovary") AnnotationAssertion(rdfs:label "ovary stroma") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37344,6 +58511,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vascular cord) +AnnotationAssertion(Annotation( "GO:0072360") Annotation( "ZFA:0005077") "The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA].") +AnnotationAssertion( "EFO:0003709") +AnnotationAssertion( "TAO:0005077") +AnnotationAssertion( "ZFA:0005077") AnnotationAssertion(rdfs:label "vascular cord") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -37353,6 +58524,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (coronary capillary) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A capillary that is part of the coronary system.") +AnnotationAssertion( "ZFA:0005813") AnnotationAssertion(rdfs:label "coronary capillary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37360,11 +58533,28 @@ SubClassOf( (anatomical surface) +AnnotationAssertion(Annotation( "CARO:0001002") "A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n.") +AnnotationAssertion( "BILA:0000010") +AnnotationAssertion( "CARO:0001002") +AnnotationAssertion( "EHDAA2_RETIRED:0003192") +AnnotationAssertion( "FMA:24137") +AnnotationAssertion( "NCIT:C34022") +AnnotationAssertion(rdfs:comment "Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism.") AnnotationAssertion(rdfs:label "anatomical surface") SubClassOf( ) # Class: (cardiogenic splanchnic mesoderm) +AnnotationAssertion(Annotation( "XAO:0000235") Annotation( "http://www.drugs.com/dict/cardiogenic-mesoderm.html") Annotation( "https://github.com/obophenotype/insect_neuroanatomy_ontology/issues/7") "The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO].") +AnnotationAssertion( "AAO:0011021") +AnnotationAssertion( "BILA:0000051") +AnnotationAssertion( "EFO:0000315") +AnnotationAssertion( "EHDAA2:0000214") +AnnotationAssertion( "EHDAA:385") +AnnotationAssertion( "FMA:293143") +AnnotationAssertion( "SCTID:360387000") +AnnotationAssertion( "VHOG:0001641") +AnnotationAssertion( "XAO:0000235") AnnotationAssertion(rdfs:label "cardiogenic splanchnic mesoderm") SubClassOf( ) SubClassOf( ) @@ -37375,6 +58565,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cleaving embryo) +AnnotationAssertion(Annotation( "OBOL:automatic") "Organism at the cleavage stage.") +AnnotationAssertion( "BILA:0000058") AnnotationAssertion(rdfs:label "cleaving embryo") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37383,6 +58575,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive gut) +AnnotationAssertion( "BILA:0000084") +AnnotationAssertion( "NCIT:C34268") +AnnotationAssertion( "SCTID:360394002") AnnotationAssertion(rdfs:label "presumptive gut") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37393,6 +58588,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mechanosensory system) +AnnotationAssertion( "BILA:0000142") AnnotationAssertion(rdfs:label "mechanosensory system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37400,12 +58596,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mandibular neural crest) +AnnotationAssertion(Annotation( "ZFA:0007064") "Cranial neural crest that migrates into the mandibular arch.") +AnnotationAssertion( "TAO:0007064") +AnnotationAssertion( "XAO:0000024") +AnnotationAssertion( "ZFA:0007064") AnnotationAssertion(rdfs:label "mandibular neural crest") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (primary circulatory organ) +AnnotationAssertion(Annotation( "GO:0007507") "A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].") +AnnotationAssertion( "TADS:0000147") +AnnotationAssertion( "http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg") +AnnotationAssertion(rdfs:comment "Gene notes: Bmp, Nkx, Gata") AnnotationAssertion(rdfs:label "primary circulatory organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37414,6 +58618,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trunk ganglion) +AnnotationAssertion(Annotation( "ZFIN:curator") "Ganglion which is located in the trunk.") +AnnotationAssertion( "EFO:0000901") +AnnotationAssertion( "MAT:0000344") +AnnotationAssertion( "MIAA:0000344") +AnnotationAssertion( "TAO:0001573") +AnnotationAssertion( "ZFA:0001573") AnnotationAssertion(rdfs:label "trunk ganglion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37421,12 +58631,87 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural keel) +AnnotationAssertion(Annotation( "ZFIN:ZDB-PUB-961014-576") "An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section.") +AnnotationAssertion( "EFO:0003497") +AnnotationAssertion( "TAO:0000131") +AnnotationAssertion( "ZFA:0000131") AnnotationAssertion(rdfs:label "neural keel") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (embryonic post-anal tail) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail.") +AnnotationAssertion( "EMAPA:16748") +AnnotationAssertion( "FMA:85540") +AnnotationAssertion(rdfs:label "embryonic post-anal tail") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (lumen of midgut) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that surrounded_by a midgut.") +AnnotationAssertion( "EMAPA:18377") +AnnotationAssertion( "FMA:54366") +AnnotationAssertion(rdfs:label "lumen of midgut") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (lumen of hindgut) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that surrounded_by a hindgut.") +AnnotationAssertion( "EMAPA:18396") +AnnotationAssertion( "FMA:54367") +AnnotationAssertion(rdfs:label "lumen of hindgut") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (lumen of anal canal) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that surrounded_by a anal canal.") +AnnotationAssertion( "EMAPA:18836") +AnnotationAssertion( "FMA:17357") +AnnotationAssertion(rdfs:label "lumen of anal canal") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (lumen of colon) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that surrounded_by a colon.") +AnnotationAssertion( "EMAPA:18945") +AnnotationAssertion( "FMA:18374") +AnnotationAssertion( "SCTID:362156004") +AnnotationAssertion(rdfs:label "lumen of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (lamina propria of mucosa of colon) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A lamina propria that is part of a colonic mucosa.") +AnnotationAssertion( "EMAPA:27395") +AnnotationAssertion( "FMA:15657") +AnnotationAssertion( "MA:0003196") +AnnotationAssertion( "SCTID:113284008") +AnnotationAssertion(rdfs:label "lamina propria of mucosa of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mesothelium of serous pericardium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesothelium that is part of a serous pericardium.") +AnnotationAssertion( "BTO:0003157") +AnnotationAssertion( "EMAPA:16133") +AnnotationAssertion( "FMA:18149") +AnnotationAssertion( "SCTID:67300002") AnnotationAssertion(rdfs:label "mesothelium of serous pericardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37434,6 +58719,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (stroma of bone marrow) +AnnotationAssertion(Annotation( "Wikipedia:Bone_marrow#Stroma") "The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis.") +AnnotationAssertion( "CALOHA:TS-0085") +AnnotationAssertion( "FMA:21426") +AnnotationAssertion( "Wikipedia:Bone_marrow#Stroma") AnnotationAssertion(rdfs:label "stroma of bone marrow") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37445,7 +58734,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tracheobronchial tree) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Tracheobronchial_tree") "The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells.") +AnnotationAssertion( "FMA:7393") +AnnotationAssertion( "NCIT:C117875") +AnnotationAssertion( "SCTID:361384001") +AnnotationAssertion( "Wikipedia:Tracheobronchial_tree") AnnotationAssertion(rdfs:label "tracheobronchial tree") SubClassOf( ) SubClassOf( ) @@ -37456,11 +58749,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (brachiocephalic vasculature) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The vasculature consisting of brachiocephalic arteries and veins.") AnnotationAssertion(rdfs:label "brachiocephalic vasculature") SubClassOf( ) # Class: (mesenchyme derived from head neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a cranial neural crest.") +AnnotationAssertion( "EFO:0003572") +AnnotationAssertion( "EHDAA2:0000735") +AnnotationAssertion( "EMAPA:16169") +AnnotationAssertion( "EMAPA:16271") +AnnotationAssertion( "EMAPA_RETIRED:16271") +AnnotationAssertion( "TAO:0000787") +AnnotationAssertion( "ZFA:0000787") AnnotationAssertion(rdfs:label "mesenchyme derived from head neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37469,6 +58771,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesenchyme derived from trunk neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a trunk neural crest.") +AnnotationAssertion( "EHDAA2:0002093") +AnnotationAssertion( "EMAPA:16182") +AnnotationAssertion( "TAO:0000999") +AnnotationAssertion( "ZFA:0000999") AnnotationAssertion(rdfs:label "mesenchyme derived from trunk neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37477,12 +58784,31 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (1st arch mandibular component) +AnnotationAssertion( "EHDAA2:0000031") +AnnotationAssertion( "EHDAA:583") +AnnotationAssertion( "EMAPA:16382") +AnnotationAssertion( "VHOG:0000510") AnnotationAssertion(rdfs:label "1st arch mandibular component") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (1st arch maxillary component) + +AnnotationAssertion( "EHDAA2:0000038") +AnnotationAssertion( "EHDAA:595") +AnnotationAssertion( "EMAPA:16388") +AnnotationAssertion(rdfs:label "1st arch maxillary component") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (tunica media of artery) +AnnotationAssertion(Annotation( "OBOL:automatic") "A tunica media that is part of a artery.") +AnnotationAssertion( "EMAPA:36294") +AnnotationAssertion( "EV:0100029") +AnnotationAssertion( "FMA:14273") +AnnotationAssertion( "NCIT:C49321") +AnnotationAssertion( "SCTID:84300001") AnnotationAssertion(rdfs:label "tunica media of artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37490,6 +58816,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tunica adventitia of artery) +AnnotationAssertion(Annotation( "OBOL:automatic") "A tunica adventitia that is part of a artery.") +AnnotationAssertion( "EMAPA:36295") +AnnotationAssertion( "EV:0100030") +AnnotationAssertion( "FMA:14274") +AnnotationAssertion( "SCTID:113261001") AnnotationAssertion(rdfs:label "tunica adventitia of artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37498,6 +58829,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tunica adventitia of vein) +AnnotationAssertion(Annotation( "OBOL:automatic") "A tunica adventitia that is part of a vein.") +AnnotationAssertion( "EMAPA:36310") +AnnotationAssertion( "EV:0100034") +AnnotationAssertion( "FMA:14355") +AnnotationAssertion( "SCTID:13202006") AnnotationAssertion(rdfs:label "tunica adventitia of vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37505,6 +58841,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tunica intima of vein) +AnnotationAssertion(Annotation( "OBOL:automatic") "A tunica intima that is part of a vein.") +AnnotationAssertion( "EMAPA:36308") +AnnotationAssertion( "EV:0100032") +AnnotationAssertion( "FMA:14353") +AnnotationAssertion( "SCTID:2436009") AnnotationAssertion(rdfs:label "tunica intima of vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37513,6 +58854,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tunica media of vein) +AnnotationAssertion(Annotation( "OBOL:automatic") "A tunica media that is part of a vein.") +AnnotationAssertion( "EMAPA:36309") +AnnotationAssertion( "EV:0100033") +AnnotationAssertion( "FMA:14354") +AnnotationAssertion( "SCTID:42049001") AnnotationAssertion(rdfs:label "tunica media of vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37520,6 +58866,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nuclear complex of neuraxis) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Gray matter of the central nervous system which is a collection of clustered nuclei.") +AnnotationAssertion( "FMA:256381") +AnnotationAssertion( "FMA:84059") AnnotationAssertion(rdfs:label "nuclear complex of neuraxis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37527,6 +58876,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nucleus of superior olivary complex) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei.") +AnnotationAssertion( "FMA:72246") +AnnotationAssertion( "SCTID:369024009") AnnotationAssertion(rdfs:label "nucleus of superior olivary complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37535,6 +58887,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trachea pre-cartilage rings) +AnnotationAssertion(Annotation( "OBOL:automatic") "A pre-cartilage condensation that is part of a trachea.") +AnnotationAssertion( "EHDAA2:0002070") +AnnotationAssertion( "EHDAA:7082") AnnotationAssertion(rdfs:label "trachea pre-cartilage rings") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37543,6 +58898,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage musculature) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of muscles that is part of a pectoral appendage.") +AnnotationAssertion( "EFO:0003540") +AnnotationAssertion( "TAO:0000563") +AnnotationAssertion( "ZFA:0000563") AnnotationAssertion(rdfs:label "pectoral appendage musculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37551,6 +58910,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (appendage musculature) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of muscles that is part of an appendage.") +AnnotationAssertion( "TAO:0000207") +AnnotationAssertion( "ZFA:0000207") AnnotationAssertion(rdfs:label "appendage musculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37558,6 +58920,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage skeleton) +AnnotationAssertion(Annotation( "VSAO:0005000") Annotation( "VSAO:NI") "Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle.") +AnnotationAssertion( "VSAO:0005000") AnnotationAssertion(rdfs:label "pectoral appendage skeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37567,6 +58931,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive hindbrain) +AnnotationAssertion(Annotation( "Wikipedia:Rhombencephalon") "The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure.") +AnnotationAssertion( "BAMS:HB") +AnnotationAssertion( "CALOHA:TS-2118") +AnnotationAssertion( "EFO:0003440") +AnnotationAssertion( "EHDAA2:0001630") +AnnotationAssertion( "FMA:295640") +AnnotationAssertion( "TAO:0000569") +AnnotationAssertion( "Wikipedia:Rhombencephalon") +AnnotationAssertion( "ZFA:0000569") AnnotationAssertion(rdfs:label "presumptive hindbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37577,6 +58950,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive sinus venosus) +AnnotationAssertion(Annotation( "ZFA:0001722") "Portion of tissue that is part of the heart tube and will become the sinus venosus.") +AnnotationAssertion( "TAO:0002234") +AnnotationAssertion( "ZFA:0001722") AnnotationAssertion(rdfs:label "presumptive sinus venosus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37585,6 +58961,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive endocardium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A presumptive structure that has the potential to develop into a endocardium.") +AnnotationAssertion( "TAO:0002233") +AnnotationAssertion( "ZFA:0001724") AnnotationAssertion(rdfs:label "presumptive endocardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37594,6 +58973,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive midbrain hindbrain boundary) +AnnotationAssertion(Annotation( "ZFA:0001187") "Embryonic structure that gives rise to the midbrain hindbrain boundary.") +AnnotationAssertion( "EFO:0003446") +AnnotationAssertion( "TAO:0001187") +AnnotationAssertion( "XAO:0004086") +AnnotationAssertion( "ZFA:0001187") AnnotationAssertion(rdfs:label "presumptive midbrain hindbrain boundary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37602,6 +58986,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive segmental plate) +AnnotationAssertion(Annotation( "OBOL:automatic") "A presumptive structure that has the potential to develop into a presomitic mesoderm.") +AnnotationAssertion( "EFO:0003421") +AnnotationAssertion( "TAO:0000053") +AnnotationAssertion( "ZFA:0000053") AnnotationAssertion(rdfs:label "presumptive segmental plate") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37610,6 +58998,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive neural plate) +AnnotationAssertion(Annotation( "OBOL:automatic") "A presumptive structure that has the potential to develop into a neural plate.") +AnnotationAssertion( "EFO:0003424") +AnnotationAssertion( "TAO:0000063") +AnnotationAssertion( "ZFA:0000063") AnnotationAssertion(rdfs:label "presumptive neural plate") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37619,6 +59011,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive paraxial mesoderm) +AnnotationAssertion(Annotation( "UBERON:cjm") Annotation( "https://github.com/obophenotype/uberon/issues/1277") "The part of the blastula that has the potential to develop into a paraxial mesoderm.") +AnnotationAssertion( "EFO:0003443") +AnnotationAssertion( "TAO:0000591") +AnnotationAssertion( "XAO:0004134") +AnnotationAssertion( "ZFA:0000591") AnnotationAssertion(rdfs:label "presumptive paraxial mesoderm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -37626,6 +59023,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a pectoral appendage.") +AnnotationAssertion( "TAO:0005301") +AnnotationAssertion( "ZFA:0005301") AnnotationAssertion(rdfs:label "pectoral appendage blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37633,6 +59033,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (appendage blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a limb/fin.") +AnnotationAssertion( "TAO:0005299") +AnnotationAssertion( "ZFA:0005299") AnnotationAssertion(rdfs:label "appendage blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37640,6 +59043,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage vasculature) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vasculature that is part of a pectoral appendage.") +AnnotationAssertion( "TAO:0005096") +AnnotationAssertion( "ZFA:0005096") AnnotationAssertion(rdfs:label "pectoral appendage vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37647,6 +59053,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal vasculature) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vasculature that is part of a chordate pharynx.") +AnnotationAssertion( "TAO:0005003") +AnnotationAssertion( "ZFA:0005003") AnnotationAssertion(rdfs:label "pharyngeal vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37654,13 +59063,65 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (appendage vasculature) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vasculature that is part of a limb/fin.") +AnnotationAssertion( "TAO:0005095") +AnnotationAssertion( "ZFA:0005095") AnnotationAssertion(rdfs:label "appendage vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreatic lobule) + +AnnotationAssertion(Annotation( "ISBN:0123813611") "A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans.") +AnnotationAssertion( "FMA:16012") +AnnotationAssertion( "MA:0000721") +AnnotationAssertion(rdfs:label "pancreatic lobule") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreatic duct) + +AnnotationAssertion(Annotation( "GOC:cvs") Annotation( "GOC:ymb") Annotation( "Wikipedia:Pancreatic_duct") Annotation( "https://github.com/obophenotype/uberon/issues/1250") Annotation( "https://orcid.org/0000-0002-2244-7917") Annotation( "https://orcid.org/0000-0002-6601-2165") Annotation( "https://orcid.org/0000-0002-9900-7880") "A duct that collects and carries secretions of the exocrine pancreas to the intestine.") +AnnotationAssertion( "EHDAA:9194") +AnnotationAssertion( "EMAPA:32952") +AnnotationAssertion( "FMA:10419") +AnnotationAssertion( "MA:0000124") +AnnotationAssertion( "SCTID:181278006") +AnnotationAssertion( "TAO:0001372") +AnnotationAssertion( "VHOG:0000254") +AnnotationAssertion( "Wikipedia:Pancreatic_duct") +AnnotationAssertion( "ZFA:0001372") +AnnotationAssertion(rdfs:label "pancreatic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (roof of mouth) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones.") +AnnotationAssertion( "CALOHA:TS-2212") +AnnotationAssertion( "Wikipedia:Palate") +AnnotationAssertion(rdfs:label "roof of mouth") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (outer epithelium) +AnnotationAssertion(Annotation( "GO:0008544") "The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO].") +AnnotationAssertion( "BSA:0000073") +AnnotationAssertion( "BTO:0000313") +AnnotationAssertion( "HAO:0000298") +AnnotationAssertion( "TADS:0000109") +AnnotationAssertion( "WBbt:0005733") +AnnotationAssertion( "Wikipedia:Epidermis_(zoology)") AnnotationAssertion(rdfs:label "outer epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37671,6 +59132,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (enveloping layer of ectoderm) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Outermost layer of cells surrounding the embryo.") +AnnotationAssertion( "EFO:0003425") +AnnotationAssertion( "TAO:0000086") +AnnotationAssertion( "ZFA:0000086") AnnotationAssertion(rdfs:label "enveloping layer of ectoderm") SubClassOf( ) SubClassOf( ) @@ -37680,6 +59145,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (paired limb/fin cartilage) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A cartilage tissue that is part of a paired limb or fin.") +AnnotationAssertion( "TAO:0001543") +AnnotationAssertion( "ZFA:0001543") AnnotationAssertion(rdfs:label "paired limb/fin cartilage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37688,6 +59156,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage cartilage tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A cartilage tissue that is part of a pectoral appendage.") +AnnotationAssertion( "TAO:0000257") +AnnotationAssertion( "ZFA:0000257") AnnotationAssertion(rdfs:label "pectoral appendage cartilage tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37697,6 +59168,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nucleus of midbrain tegmentum) +AnnotationAssertion(Annotation( "OBOL:automatic") "A nucleus of brain that spans a midbrain tegmentum.") +AnnotationAssertion( "FMA:258768") +AnnotationAssertion( "ZFA:0005577") AnnotationAssertion(rdfs:label "nucleus of midbrain tegmentum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37704,6 +59178,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lumen of epithelial sac) +AnnotationAssertion(Annotation( "AEO:JB") "The space within an epithelial sphere.") +AnnotationAssertion( "AEO:0000079") AnnotationAssertion(rdfs:label "lumen of epithelial sac") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37711,6 +59187,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (matrix-based tissue) +AnnotationAssertion(Annotation( "AEO:JB") "A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified.") +AnnotationAssertion( "AEO:0000081") +AnnotationAssertion( "EHDAA2:0003081") AnnotationAssertion(rdfs:label "matrix-based tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37718,6 +59197,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelial sac) +AnnotationAssertion(Annotation( "AEO:JB") Annotation( "UBERONREF:0000001") "An epithelial tube that is open at one end only.") +AnnotationAssertion( "AEO:0000115") +AnnotationAssertion( "EHDAA2:0003115") AnnotationAssertion(rdfs:label "epithelial sac") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37725,22 +59207,57 @@ SubClassOf( (epithelial tube open at both ends) +AnnotationAssertion(Annotation( "AEO:JB") Annotation( "UBERONREF:0000001") "An epithelial tube open at both ends that allows fluid flow.") +AnnotationAssertion( "AEO_RETIRED:0000116") +AnnotationAssertion( "RETIRED_EHDAA2:0003116") AnnotationAssertion(rdfs:label "epithelial tube open at both ends") SubClassOf( ) # Class: (epithelial vesicle) +AnnotationAssertion(Annotation( "AEO:JB") "A closed epithelium with a lumen.") +AnnotationAssertion( "AEO:0000119") +AnnotationAssertion( "EHDAA2:0003119") AnnotationAssertion(rdfs:label "epithelial vesicle") SubClassOf( ) +# Class: (smooth muscle sphincter) + +AnnotationAssertion(Annotation( "AEO:JB") "A ring of smooth muscle cells whose contraction closes the opening of the ring.") +AnnotationAssertion( "AEO:0000143") +AnnotationAssertion( "EHDAA2:0003143") +AnnotationAssertion( "SCTID:362915001") +AnnotationAssertion(rdfs:label "smooth muscle sphincter") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (striated muscle sphincter) + +AnnotationAssertion(Annotation( "AEO:JB") "A ring of striated muscle cells whose contraction closes the opening of the ring.") +AnnotationAssertion( "AEO:0000144") +AnnotationAssertion( "EHDAA2:0003144") +AnnotationAssertion(rdfs:label "striated muscle sphincter") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (dense mesenchyme tissue) +AnnotationAssertion(Annotation( "AEO:JB") "Mesenchyme with little extracellular matrix.") +AnnotationAssertion( "AEO:0000146") +AnnotationAssertion( "EHDAA2:0003146") AnnotationAssertion(rdfs:label "dense mesenchyme tissue") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (migrating mesenchyme population) +AnnotationAssertion(Annotation( "AEO:JB") "Mesenchymal cells that are migrating.") +AnnotationAssertion( "AEO:0000152") +AnnotationAssertion( "EHDAA2:0003152") AnnotationAssertion(rdfs:label "migrating mesenchyme population") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37748,6 +59265,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ciliated columnar epithelium) +AnnotationAssertion(Annotation( "FMA:64798") "Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA].") +AnnotationAssertion( "FMA:64798") AnnotationAssertion(rdfs:label "ciliated columnar epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37755,6 +59274,7 @@ SubClassOf( (ciliated epithelium) +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/ciliated+epithelium") "Epithelium bearing vibratile cilia on the free surface.") AnnotationAssertion(rdfs:label "ciliated epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37762,6 +59282,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (layer of synovial tissue) +AnnotationAssertion(Annotation( "BTO:0001338") Annotation( "http://www.britannica.com/EBchecked/topic/578563/synovial-tissue") "A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO].") +AnnotationAssertion( "BTO:0001338") +AnnotationAssertion( "CALOHA:TS-0998") +AnnotationAssertion( "FMA:66762") AnnotationAssertion(rdfs:label "layer of synovial tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37770,6 +59294,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (synovial cavity of joint) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that surrounded_by a synovial joint.") +AnnotationAssertion( "FMA:11356") AnnotationAssertion(rdfs:label "synovial cavity of joint") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37777,6 +59303,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pigment epithelium of eye) +AnnotationAssertion(Annotation( "MP:0005200") "Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules.") +AnnotationAssertion( "GAID:907") +AnnotationAssertion( "MESH:D010857") AnnotationAssertion(rdfs:label "pigment epithelium of eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37784,6 +59313,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nucleus of medulla oblongata) +AnnotationAssertion(Annotation( "OBOL:automatic") "A neural nucleus that is part of a medulla oblongata.") +AnnotationAssertion( "FMA:258772") +AnnotationAssertion( "SCTID:304943004") AnnotationAssertion(rdfs:label "nucleus of medulla oblongata") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37792,6 +59324,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trigeminal nuclear complex) +AnnotationAssertion(Annotation( "Wikipedia:Trigeminal_nerve_nuclei") "The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP].") +AnnotationAssertion( "BIRNLEX:4096") +AnnotationAssertion( "BM:V") +AnnotationAssertion( "CALOHA:TS-2077") +AnnotationAssertion( "DHBA:266441713") +AnnotationAssertion( "FMA:71248") +AnnotationAssertion( "HBA:9203") +AnnotationAssertion( "Wikipedia:Trigeminal_nerve_nuclei") +AnnotationAssertion( "neuronames:2021") AnnotationAssertion(rdfs:label "trigeminal nuclear complex") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -37799,21 +59340,41 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anatomical junction) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://code.google.com/p/caro2/issues/detail?id=15") "An anatomical structure that connects two structures.") +AnnotationAssertion( "FMA:5898") +AnnotationAssertion( "SCTID:91833003") AnnotationAssertion(rdfs:label "anatomical junction") SubClassOf( ) SubClassOf( ObjectMinCardinality(2 )) +# Class: (esophageal sphincter) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A sphincter that is part of an esophagus.") +AnnotationAssertion( "SCTID:277765007") +AnnotationAssertion(rdfs:label "esophageal sphincter") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (anlage) +AnnotationAssertion(Annotation( "FBbt:00005426") Annotation( "http://flybase.org/reports/FBrf0178740.html") "Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue.") +AnnotationAssertion( "AEO:0000170") +AnnotationAssertion( "EFO:0001649") +AnnotationAssertion( "EHDAA2:0003170") +AnnotationAssertion( "Wikipedia:Anlage_(biology)") AnnotationAssertion(rdfs:label "anlage") SubClassOf( ) SubClassOf( ) # Class: (early pharyngeal endoderm) +AnnotationAssertion( "EFO:0003626") +AnnotationAssertion( "EHDAA2:0001457") +AnnotationAssertion( "EHDAA:962") +AnnotationAssertion( "TAO:0001104") +AnnotationAssertion( "ZFA:0001104") +AnnotationAssertion(rdfs:comment "relation conflict: ZFA vs EHDAA2. Note EHDAA2 term renamed to 'early PA endoderm'") AnnotationAssertion(rdfs:label "early pharyngeal endoderm") SubClassOf( ) SubClassOf( ) @@ -37821,6 +59382,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bone of reproductive organ) +AnnotationAssertion(Annotation( "OBOL:automatic") Annotation( "https://github.com/obophenotype/uberon/issues/1158") "A bone that is part of a reproductive organ.") AnnotationAssertion(rdfs:label "bone of reproductive organ") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37829,6 +59391,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epidermis gland) +AnnotationAssertion(Annotation( "OBOL:automatic") "A gland that is part of a epidermis.") +AnnotationAssertion( "FMA:59153") AnnotationAssertion(rdfs:label "epidermis gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37836,6 +59400,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (transudate) +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/transudate") "Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces.") +AnnotationAssertion( "FMA:12276") +AnnotationAssertion( "GAID:1195") +AnnotationAssertion( "MESH:D005122") +AnnotationAssertion( "ncithesaurus:Transudate") AnnotationAssertion(rdfs:label "transudate") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37845,6 +59414,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (secretion of serous gland) +AnnotationAssertion(Annotation( "UBERON:cjm") "Any fluid produced by a serous gland.") +AnnotationAssertion( "Wikipedia:Serous_fluid") AnnotationAssertion(rdfs:label "secretion of serous gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37853,13 +59424,22 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vascular system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Anatomical system that consists of all blood and lymph vessels.") +AnnotationAssertion( "BTO:0001085") +AnnotationAssertion( "CALOHA:TS-2053") +AnnotationAssertion( "EHDAA2:0004520") +AnnotationAssertion( "EMAPA:35905") +AnnotationAssertion( "MA:0002718") +AnnotationAssertion( "NCIT:C33854") AnnotationAssertion(rdfs:label "vascular system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (adipose tissue of abdominal region) +AnnotationAssertion(Annotation( "CALOHA:paula") Annotation( "MGI:csmith") Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/259") "Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots.") +AnnotationAssertion( "CALOHA:TS-0002") +AnnotationAssertion( "EFO:0003771") AnnotationAssertion(rdfs:label "adipose tissue of abdominal region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37867,6 +59447,15 @@ SubClassOf( (craniocervical region) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae.") +AnnotationAssertion( "CALOHA:TS-2356") +AnnotationAssertion( "EV:0100009") +AnnotationAssertion( "FMA:280881") +AnnotationAssertion( "MA:0000006") +AnnotationAssertion( "NCIT:C12418") +AnnotationAssertion( "SCTID:361355005") +AnnotationAssertion( "WikipediaCategory:Head_and_neck") +AnnotationAssertion( "galen:HeadAndNeck") AnnotationAssertion(rdfs:label "craniocervical region") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -37874,8 +59463,28 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (post-anal tail) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton.") +AnnotationAssertion( "AAO:0010338") +AnnotationAssertion( "MA:0000008") +AnnotationAssertion( "NCIT:C77663") +AnnotationAssertion( "TAO:0001117") +AnnotationAssertion( "XAO:0003026") +AnnotationAssertion( "ZFA:0001117") +AnnotationAssertion(rdfs:label "post-anal tail") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (appendage girdle region) +AnnotationAssertion(Annotation( "UBERONREF:0000003") Annotation( "https://orcid.org/0000-0002-6601-2165") "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).") +AnnotationAssertion( "FMA:24874") +AnnotationAssertion( "VSAO:0000303") AnnotationAssertion(rdfs:label "appendage girdle region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37883,8 +59492,24 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (peritoneal mesentery) + +AnnotationAssertion(Annotation( "UBERON:cjm") "Mesentery that is located in the peritoneum.") +AnnotationAssertion( "FMA:20570") +AnnotationAssertion( "TAO:0005129") +AnnotationAssertion( "XAO:0000138") +AnnotationAssertion( "ZFA:0005129") +AnnotationAssertion(rdfs:label "peritoneal mesentery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (girdle bone/zone) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of a appendage girdle region.") +AnnotationAssertion( "EMAPA:35379") +AnnotationAssertion( "MA:0000291") AnnotationAssertion(rdfs:label "girdle bone/zone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37892,7 +59517,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral girdle bone) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of a pectoral girdle region.") +AnnotationAssertion( "EMAPA:35669") +AnnotationAssertion( "MA:0000292") AnnotationAssertion(rdfs:label "pectoral girdle bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37901,6 +59528,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral girdle skeleton) +AnnotationAssertion(Annotation( "Wikipedia:Pectoral_girdle") "A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons.") +AnnotationAssertion( "AAO:0000422") +AnnotationAssertion( "AAO:0000754") +AnnotationAssertion( "EFO:0000946") +AnnotationAssertion( "EHDAA2:0001420") +AnnotationAssertion( "FMA:24141") +AnnotationAssertion( "MAT:0000181") +AnnotationAssertion( "MIAA:0000181") +AnnotationAssertion( "NCIT:C33547") +AnnotationAssertion( "TAO:0000407") +AnnotationAssertion( "VHOG:0001156") +AnnotationAssertion( "VSAO:0000156") +AnnotationAssertion( "Wikipedia:Pectoral_girdle") +AnnotationAssertion( "XAO:0003063") +AnnotationAssertion( "ZFA:0000407") AnnotationAssertion(rdfs:label "pectoral girdle skeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37910,12 +59552,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (membrane bone) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "VSAO:0000023") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "https://github.com/obophenotype/uberon/issues/267") "Bone element that arises as a result of intramembranous ossification.") +AnnotationAssertion( "AEO:0000085") +AnnotationAssertion( "EHDAA2:0003085") +AnnotationAssertion( "TAO:0001645") +AnnotationAssertion( "VSAO:0000023") +AnnotationAssertion( "XAO:0004014") +AnnotationAssertion( "ZFA:0001636") AnnotationAssertion(rdfs:label "membrane bone") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cartilage element) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000000") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Skeletal element that is composed of cartilage tissue and may be permanent or transient.") +AnnotationAssertion( "AAO:0011130") +AnnotationAssertion( "CALOHA:TS-0118") +AnnotationAssertion( "FMA:55107") +AnnotationAssertion( "VSAO:0000000") +AnnotationAssertion( "XAO:0004013") +AnnotationAssertion( "ZFA:0001501") AnnotationAssertion(rdfs:label "cartilage element") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37925,6 +59581,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (regular connective tissue) +AnnotationAssertion(Annotation( "FMA:20103") "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue.") +AnnotationAssertion( "FMA:20103") AnnotationAssertion(rdfs:label "regular connective tissue") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -37934,6 +59592,13 @@ DisjointClasses( (dense regular connective tissue) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000050") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).") +AnnotationAssertion( "FMA:64781") +AnnotationAssertion( "NCIT:C33453") +AnnotationAssertion( "SCTID:22560007") +AnnotationAssertion( "VSAO:0000050") +AnnotationAssertion( "Wikipedia:Dense_regular_connective_tissue") +AnnotationAssertion( "XAO:0004030") AnnotationAssertion(rdfs:label "dense regular connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37941,13 +59606,27 @@ SubClassOf( (bone of craniocervical region) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of a craniocervical region.") +AnnotationAssertion( "MA:0000569") AnnotationAssertion(rdfs:label "bone of craniocervical region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (irregular bone) + +AnnotationAssertion(Annotation( "Wikipedia:Irregular_bone") "The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid.") +AnnotationAssertion( "FMA:7477") +AnnotationAssertion( "NCIT:C32881") +AnnotationAssertion( "SCTID:421560006") +AnnotationAssertion( "Wikipedia:Irregular_bone") +AnnotationAssertion(rdfs:label "irregular bone") +SubClassOf( ) + # Class: (joint of girdle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A skeletal joint that is part of a appendage girdle region.") +AnnotationAssertion( "MA:0001505") AnnotationAssertion(rdfs:label "joint of girdle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37957,13 +59636,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (surface of cartilage) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical surface that is part of a cartilage element.") +AnnotationAssertion( "FMA:76668") AnnotationAssertion(rdfs:label "surface of cartilage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pneumatized bone) + +AnnotationAssertion(Annotation( "http://www.medilexicon.com/medicaldictionary.php?t=11303") "A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD].") +AnnotationAssertion( "FMA:7478") +AnnotationAssertion( "SCTID:333008005") +AnnotationAssertion( "Wikipedia:Skeletal_pneumaticity") +AnnotationAssertion( "galen:PneumaticBone") +AnnotationAssertion(rdfs:label "pneumatized bone") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (muscle of pectoral girdle) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a pectoral girdle region.") +AnnotationAssertion( "FMA:37347") AnnotationAssertion(rdfs:label "muscle of pectoral girdle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37971,6 +59666,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (craniocervical region musculature) +AnnotationAssertion(Annotation( "ZFA:0000328") Annotation( "ZFA:curator") "Musculature system of the pharyngeal and head regions.") +AnnotationAssertion( "MA:0000571") +AnnotationAssertion( "TAO:0000328") +AnnotationAssertion( "ZFA:0000328") AnnotationAssertion(rdfs:label "craniocervical region musculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37978,6 +59677,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dorsal thoracic segment of trunk) +AnnotationAssertion(Annotation( "FMA:24217") "Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax.") +AnnotationAssertion( "FMA:24217") +AnnotationAssertion( "MA:0000028") +AnnotationAssertion( "SCTID:362666008") AnnotationAssertion(rdfs:label "dorsal thoracic segment of trunk") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -37985,6 +59688,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (upper back muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscle of back that is part of a dorsal thoracic segment of trunk.") +AnnotationAssertion( "MA:0000508") +AnnotationAssertion( "SCTID:305071003") AnnotationAssertion(rdfs:label "upper back muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -37993,6 +59699,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart endothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of a heart [Automatically generated definition].") +AnnotationAssertion( "BTO:0004293") AnnotationAssertion(rdfs:label "heart endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38000,13 +59708,39 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (microvascular endothelium) +AnnotationAssertion( "BTO:0003122") AnnotationAssertion(rdfs:label "microvascular endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (intestinal villus of duodenum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An intestinal villus in the duodenum.") +AnnotationAssertion( "FMA:63300") +AnnotationAssertion(rdfs:label "intestinal villus of duodenum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (duodenal epithelium) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a duodenum.") +AnnotationAssertion( "CALOHA:TS-2087") +AnnotationAssertion( "EMAPA:19078") +AnnotationAssertion( "FMA:17231") +AnnotationAssertion( "MA:0003208") +AnnotationAssertion( "SCTID:66036002") +AnnotationAssertion(rdfs:label "duodenal epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (tracheobronchial epithelium) +AnnotationAssertion(Annotation( "Dorlands_Medical_Dictionary:MerckMedicus") "Epithelium pertaining to the trachea and bronchi.") +AnnotationAssertion( "BTO:0002925") +AnnotationAssertion( "CALOHA:TS-1063") AnnotationAssertion(rdfs:label "tracheobronchial epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38014,6 +59748,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (inner cell mass derived epiblast) +AnnotationAssertion(Annotation( "MP:0003886") "An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers.") +AnnotationAssertion( "EHDAA2:0000444") +AnnotationAssertion( "EHDAA:42") +AnnotationAssertion( "EHDAA:75") +AnnotationAssertion( "EMAPA:16050") +AnnotationAssertion( "NCIT:C34164") +AnnotationAssertion(rdfs:comment "The epiblast cells (appearing on day 8 of human embryonic development) make up a columnar epithelium with dense microvilli on the apical surface. During gastrulation, the epiblast cells undergo epithelial-to-mesenchymal transition and delaminate to become the loose mesenchyme of the primitive streak. The epiblast is present in postimplantation mouse embryos between E5.5-E7.5.") AnnotationAssertion(rdfs:label "inner cell mass derived epiblast") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38022,6 +59763,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch system) +AnnotationAssertion(Annotation( "GO:0060037") Annotation( "GOC:dph") "A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified].") +AnnotationAssertion( "EHDAA2:0000187") +AnnotationAssertion( "FMA:293041") +AnnotationAssertion( "NCIT:C34248") AnnotationAssertion(rdfs:label "pharyngeal arch system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38030,6 +59775,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (embryonic head) +AnnotationAssertion(Annotation( "OBOL:automatic") "A head that is part of a embryo.") +AnnotationAssertion( "CALOHA:TS-0246") +AnnotationAssertion( "FMA:293011") AnnotationAssertion(rdfs:label "embryonic head") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38037,6 +59785,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural tube derived brain) +AnnotationAssertion(Annotation( "OBOL:automatic") Annotation( "https://github.com/obophenotype/uberon/issues/338") "A brain that develops_from a neural tube.") AnnotationAssertion(rdfs:label "neural tube derived brain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38046,23 +59795,102 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pulmonary surfactant) +AnnotationAssertion(Annotation( "Wikipedia:Pulmonary_surfactant") "A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein).") +AnnotationAssertion( "EMAPA:36551") +AnnotationAssertion( "FMA:62780") +AnnotationAssertion( "MA:0002534") +AnnotationAssertion( "NCIT:C13273") +AnnotationAssertion( "Wikipedia:Pulmonary_surfactant") AnnotationAssertion(rdfs:label "pulmonary surfactant") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepatic diverticulum) + +AnnotationAssertion(Annotation( "MP:MP") Annotation( "http://www.stembook.org/node/512") "An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts.") +AnnotationAssertion( "AAO:0011057") +AnnotationAssertion( "EHDAA2:0000740") +AnnotationAssertion( "EHDAA:1530") +AnnotationAssertion( "NCIT:C34187") +AnnotationAssertion( "Wikipedia:Hepatic_diverticulum") +AnnotationAssertion( "XAO:0000101") +AnnotationAssertion(rdfs:label "hepatic diverticulum") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (liver bud) + +AnnotationAssertion( "BTO:0001642") +AnnotationAssertion(rdfs:label "liver bud") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (ectoplacental cavity) +AnnotationAssertion(Annotation( "MP:0011207") Annotation( "http://www.medilexicon.com/medicaldictionary.php?s=epamniotic+cavity") "Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals.") +AnnotationAssertion( "EMAPA:16080") AnnotationAssertion(rdfs:label "ectoplacental cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (stomach muscularis externa) + +AnnotationAssertion(Annotation( "MP:0010779") "The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines.") +AnnotationAssertion( "FMA:14909") +AnnotationAssertion( "SCTID:362132003") +AnnotationAssertion(rdfs:label "stomach muscularis externa") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pyloric canal) + +AnnotationAssertion(Annotation( "MP:0010791") Annotation( "Wikipedia:Pyloric_canal") "The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter.") +AnnotationAssertion( "FMA:14580") +AnnotationAssertion( "SCTID:245417002") +AnnotationAssertion( "Wikipedia:Pyloric_canal") +AnnotationAssertion(rdfs:label "pyloric canal") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pyloric gastric gland) + +AnnotationAssertion(Annotation( "MP:0010797") Annotation( "Wikipedia:Pyloric_gland") "The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP].") +AnnotationAssertion( "EMAPA:27211") +AnnotationAssertion( "FMA:14922") +AnnotationAssertion( "NCIT:C33431") +AnnotationAssertion( "SCTID:70710007") +AnnotationAssertion( "Wikipedia:Pyloric_gland") +AnnotationAssertion(rdfs:label "pyloric gastric gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (pulmonary alveolar parenchyma) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MP:0010901") "The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages.") AnnotationAssertion(rdfs:label "pulmonary alveolar parenchyma") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38074,7 +59902,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pulmonary acinus) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "MP:0010911") Annotation( "PMID:2014492") Annotation( "PMID:3382030") Annotation( "Wikipedia:Acinus#The_Lungs") "The largest lung subunit in which all airways participate in gas exchange, and it is composed of the parenchyma of the respiratory bronchioles, alveolar ducts, and alveoli.") +AnnotationAssertion( "FMA:7313") +AnnotationAssertion( "NCIT:C33426") +AnnotationAssertion( "SCTID:361365004") +AnnotationAssertion( "Wikipedia:Acinus#The_Lungs") AnnotationAssertion(rdfs:label "pulmonary acinus") SubClassOf( ) SubClassOf( ) @@ -38083,6 +59915,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (hypodermis skeletal muscle layer) +AnnotationAssertion(Annotation( "ISBN:0123813611") Annotation( "MP:0011157") "Any skeletal muscle organ in the hypodermis / superficial fascia.") +AnnotationAssertion( "EMAPA:18188") +AnnotationAssertion( "MA:0003140") AnnotationAssertion(rdfs:label "hypodermis skeletal muscle layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38096,7 +59931,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pulmonary vascular system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Pulmonary_circulation") "The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins.") +AnnotationAssertion( "FMA:45621") +AnnotationAssertion( "Wikipedia:Pulmonary_circulation") AnnotationAssertion(rdfs:label "pulmonary vascular system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38104,7 +59941,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (splanchnocranium) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Facial_skeleton") Annotation( "https://orcid.org/0000-0002-6601-2165") "Subdivision of endoskeleton derived from pharyngeal arches.") +AnnotationAssertion( "AAO:0010157") +AnnotationAssertion( "TAO:0001216") +AnnotationAssertion( "VHOG:0000315") +AnnotationAssertion( "VSAO:0000149") +AnnotationAssertion( "Wikipedia:Facial_skeleton") +AnnotationAssertion( "XAO:0003176") +AnnotationAssertion( "ZFA:0001216") AnnotationAssertion(rdfs:label "splanchnocranium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38113,6 +59957,13 @@ DisjointClasses( (dermal bone) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "VSAO:0000130") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "https://github.com/obophenotype/uberon/issues/267") "Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO].") +AnnotationAssertion( "AAO:0010769") +AnnotationAssertion( "TAO:0001590") +AnnotationAssertion( "VSAO:0000130") +AnnotationAssertion( "Wikipedia:Dermal_bone") +AnnotationAssertion( "XAO:0004015") +AnnotationAssertion( "ZFA:0001590") AnnotationAssertion(rdfs:label "dermal bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38121,6 +59972,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (perichordal bone) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "VSAO:0000307") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Bone element that is adjacent to the notochord.") +AnnotationAssertion( "AAO:0010777") +AnnotationAssertion( "TAO:0001639") +AnnotationAssertion( "VSAO:0000307") +AnnotationAssertion( "ZFA:0001629") AnnotationAssertion(rdfs:label "perichordal bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38128,6 +59984,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung parenchyma) +AnnotationAssertion(Annotation( "OBOL:automatic") "A parenchyma that is part of a lung.") +AnnotationAssertion( "EMAPA:35522") +AnnotationAssertion( "FMA:27360") +AnnotationAssertion( "MA:0003168") +AnnotationAssertion( "SCTID:201712001") AnnotationAssertion(rdfs:label "lung parenchyma") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38136,6 +59997,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory primordium) +AnnotationAssertion( "EHDAA2:0004069") +AnnotationAssertion( "NCIT:C34283") AnnotationAssertion(rdfs:label "respiratory primordium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38143,13 +60006,42 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left lung lobe) +AnnotationAssertion(Annotation( "OBOL:automatic") "A lobe of lung that is part of a left lung.") +AnnotationAssertion( "EHDAA:2981") +AnnotationAssertion( "NCIT:C48945") +AnnotationAssertion( "SCTID:272655003") AnnotationAssertion(rdfs:label "left lung lobe") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (submucosal esophageal gland) + +AnnotationAssertion(Annotation( "BTO:0003634") Annotation( "Wikipedia:Esophageal_glands") "One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed.") +AnnotationAssertion( "BTO:0003634") +AnnotationAssertion( "FMA:9404") +AnnotationAssertion( "NCIT:C32536") +AnnotationAssertion( "SCTID:322749003") +AnnotationAssertion( "Wikipedia:Esophageal_glands") +AnnotationAssertion(rdfs:label "submucosal esophageal gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vasculature of brain) +AnnotationAssertion(Annotation( "BTO:0003840") "System pertaining to blood vessels in the brain.") +AnnotationAssertion( "BTO:0003840") +AnnotationAssertion( "EFO:0003491") +AnnotationAssertion( "EMAPA:35186") +AnnotationAssertion( "FMA:242007") +AnnotationAssertion( "FMA:61935") +AnnotationAssertion( "SCTID:362029003") +AnnotationAssertion( "TAO:0000099") +AnnotationAssertion( "ZFA:0000099") AnnotationAssertion(rdfs:label "vasculature of brain") SubClassOf( ) SubClassOf( ) @@ -38157,6 +60049,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (upper back skin) +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a dorsal thoracic segment of trunk.") +AnnotationAssertion( "MA:0000510") +AnnotationAssertion( "SCTID:304890003") AnnotationAssertion(rdfs:label "upper back skin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38165,6 +60060,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left pulmonary vein) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Vein that drains left lung and returns blood to the heart.") +AnnotationAssertion( "MA:0002207") +AnnotationAssertion( "NCIT:C48946") +AnnotationAssertion( "SCTID:304057004") AnnotationAssertion(rdfs:label "left pulmonary vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38172,6 +60071,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right pulmonary vein) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Vein that drains right lung and returns blood to the heart.") +AnnotationAssertion( "MA:0002208") +AnnotationAssertion( "NCIT:C48947") +AnnotationAssertion( "SCTID:304056008") AnnotationAssertion(rdfs:label "right pulmonary vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38179,13 +60082,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (indifferent gonad) +AnnotationAssertion(Annotation( "http://www.medterms.com/script/main/art.asp?articlekey=8981") "A gonad prior to differentiating into a definitive testis or ovary.") +AnnotationAssertion( "EHDAA2:0000716") +AnnotationAssertion( "NCIT:C34192") +AnnotationAssertion(rdfs:comment "typically part of the embryo - however, in male tammar wallabies the gonads are indifferent at the neonatal stage[8827321]") AnnotationAssertion(rdfs:label "indifferent gonad") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (epibranchial ganglion) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:20133851") Annotation( "ZFIN:curator") "Cranial ganglion which develops from an epibranchial placode.") +AnnotationAssertion( "TAO:0001555") +AnnotationAssertion( "ZFA:0001555") +AnnotationAssertion(rdfs:comment "Epibranchial ganglia orchestrate the development of the cranial neurogenic crest") AnnotationAssertion(rdfs:label "epibranchial ganglion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38194,6 +60104,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right atrium endocardium) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Endocardium that is part of the right atrium.") +AnnotationAssertion( "EHDAA2:0000274") +AnnotationAssertion( "FMA:7281") +AnnotationAssertion( "NCIT:C102339") +AnnotationAssertion( "SCTID:3194006") +AnnotationAssertion( "VHOG:0001228") AnnotationAssertion(rdfs:label "right atrium endocardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38206,6 +60122,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pleuroperitoneal membrane) +AnnotationAssertion(Annotation( "Wikipedia:Pleuroperitoneal") Annotation( "http://medical-dictionary.thefreedictionary.com/pleuroperitoneal+membrane") "A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities.") +AnnotationAssertion( "EHDAA2:0001483") +AnnotationAssertion( "EMAPA:17709") +AnnotationAssertion( "NCIT:C34256") +AnnotationAssertion( "SCTID:361429005") +AnnotationAssertion( "VHOG:0000757") +AnnotationAssertion( "Wikipedia:Pleuroperitoneal") AnnotationAssertion(rdfs:label "pleuroperitoneal membrane") SubClassOf( ) SubClassOf( ) @@ -38214,6 +60137,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (craniocervical region vein) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vein that is part of a craniocervical region.") +AnnotationAssertion( "EHDAA2:0004542") +AnnotationAssertion( "SCTID:32945007") AnnotationAssertion(rdfs:label "craniocervical region vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38221,6 +60147,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (entire embryonic mesenchyme) +AnnotationAssertion(Annotation( "https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/7") "Sum total of mesenchyme in the embryo.") +AnnotationAssertion( "EHDAA2:0001113") +AnnotationAssertion( "EHDAA:177") +AnnotationAssertion( "EMAPA:16097") AnnotationAssertion(rdfs:label "entire embryonic mesenchyme") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38229,18 +60159,73 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal region of foregut) +AnnotationAssertion( "EMAPA:16549") +AnnotationAssertion( "RETIRED_EHDAA2:0001454") AnnotationAssertion(rdfs:label "pharyngeal region of foregut") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (sphenoid bone pre-cartilage condensation) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation.") +AnnotationAssertion( "EHDAA2:0003446") +AnnotationAssertion( "EMAPA:18015") +AnnotationAssertion(rdfs:label "sphenoid bone pre-cartilage condensation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (sphenoid cartilage element) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A sphenoid endochondral element that is composed primarily of cartilage tissue.") +AnnotationAssertion( "EHDAA2:0001888") +AnnotationAssertion(rdfs:label "sphenoid cartilage element") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (indifferent external genitalia) +AnnotationAssertion( "EHDAA2:0004021") AnnotationAssertion(rdfs:label "indifferent external genitalia") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (medial nasal process mesenchyme) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a medial nasal prominence.") +AnnotationAssertion( "EHDAA2:0001077") +AnnotationAssertion( "EMAPA:16810") +AnnotationAssertion( "FMA:312659") +AnnotationAssertion(rdfs:label "medial nasal process mesenchyme") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (embryonic nasal process) + +AnnotationAssertion( "EHDAA2:0000581") +AnnotationAssertion( "EHDAA:4776") +AnnotationAssertion( "EMAPA:16680") +AnnotationAssertion( "SCTID:308881001") +AnnotationAssertion(rdfs:label "embryonic nasal process") +SubClassOf( ) + # Class: (ectoderm of buccopharyngeal membrane) +AnnotationAssertion(Annotation( "OBOL:automatic") "An ectoderm that is part of a buccopharyngeal membrane.") +AnnotationAssertion( "EHDAA2:0000190") +AnnotationAssertion( "EMAPA:16260") AnnotationAssertion(rdfs:label "ectoderm of buccopharyngeal membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38248,13 +60233,40 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endoderm of buccopharyngeal membrane) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endoderm that is part of a buccopharyngeal membrane.") +AnnotationAssertion( "EHDAA2:0000191") +AnnotationAssertion( "EMAPA:16261") AnnotationAssertion(rdfs:label "endoderm of buccopharyngeal membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (associated mesenchyme of foregut-midgut junction) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a foregut-midgut junction.") +AnnotationAssertion( "EHDAA2:0000570") +AnnotationAssertion( "EMAPA:16364") +AnnotationAssertion(rdfs:label "associated mesenchyme of foregut-midgut junction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mesentery of foregut-midgut junction) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mesentery that is part of a foregut-midgut junction.") +AnnotationAssertion( "EHDAA2:0000575") +AnnotationAssertion( "EMAPA:16365") +AnnotationAssertion( "VHOG:0000430") +AnnotationAssertion(rdfs:label "mesentery of foregut-midgut junction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (pharyngeal arch mesenchymal region) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A portion of mesenchymal tissue associated with an individual pharyngeal arch.") +AnnotationAssertion( "EMAPA:32755") +AnnotationAssertion( "FMA:295694") AnnotationAssertion(rdfs:label "pharyngeal arch mesenchymal region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38263,8 +60275,47 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelium of foregut-midgut junction) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a foregut-midgut junction.") +AnnotationAssertion( "EHDAA2:0000573") +AnnotationAssertion( "EMAPA:16564") +AnnotationAssertion(rdfs:label "epithelium of foregut-midgut junction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mesenchyme of fronto-nasal process) + +AnnotationAssertion(Annotation( "MP:0011266") "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head.") +AnnotationAssertion( "EHDAA2:0004109") +AnnotationAssertion( "EMAPA:16683") +AnnotationAssertion( "FMA:295821") +AnnotationAssertion(rdfs:label "mesenchyme of fronto-nasal process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mesenchyme of hindgut) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing hindgut.") +AnnotationAssertion( "EHDAA2:0000780") +AnnotationAssertion( "EMAPA:16716") +AnnotationAssertion(rdfs:label "mesenchyme of hindgut") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mesenchyme of trachea) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing trachea.") +AnnotationAssertion( "EHDAA2:0002067") +AnnotationAssertion( "EMAPA:16854") AnnotationAssertion(rdfs:label "mesenchyme of trachea") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38272,14 +60323,98 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (anal membrane endodermal component) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An endoderm that is part of a anal region.") +AnnotationAssertion( "EHDAA2:0004020") +AnnotationAssertion( "EMAPA:17177") +AnnotationAssertion(rdfs:label "anal membrane endodermal component") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (maxillary process mesenchyme) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a maxillary prominence.") +AnnotationAssertion( "EHDAA2:0001071") +AnnotationAssertion( "EMAPA:17361") +AnnotationAssertion( "FMA:312691") +AnnotationAssertion(rdfs:label "maxillary process mesenchyme") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (hepatic sinusoid of left of lobe of liver) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A hepatic sinusoid that is part of a left lobe of liver.") +AnnotationAssertion( "EHDAA2:0001001") +AnnotationAssertion( "EMAPA:18309") +AnnotationAssertion( "VHOG:0000709") +AnnotationAssertion(rdfs:label "hepatic sinusoid of left of lobe of liver") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (hepatic sinusoid of right of lobe of liver) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A hepatic sinusoid that is part of a right lobe of liver.") +AnnotationAssertion( "EHDAA2:0001009") +AnnotationAssertion( "EMAPA:18316") +AnnotationAssertion( "VHOG:0000710") +AnnotationAssertion(rdfs:label "hepatic sinusoid of right of lobe of liver") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (endoderm of foregut-midgut junction) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An endoderm that is part of a foregut-midgut junction.") +AnnotationAssertion( "EHDAA2:0000572") +AnnotationAssertion( "EMAPA:18403") +AnnotationAssertion(rdfs:label "endoderm of foregut-midgut junction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (intestinal submucosa) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a intestine.") +AnnotationAssertion( "FMA:15696") +AnnotationAssertion(rdfs:label "intestinal submucosa") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (trunk region of vertebral column) + +AnnotationAssertion(Annotation( "UBERONREF:0000006") "Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions.") +AnnotationAssertion( "FMA:72066") +AnnotationAssertion( "NCIT:C92597") +AnnotationAssertion( "SCTID:281699004") +AnnotationAssertion(rdfs:label "trunk region of vertebral column") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (subdivision of trunk) +AnnotationAssertion( "FMA:25054") +AnnotationAssertion( "SCTID:22943007") AnnotationAssertion(rdfs:label "subdivision of trunk") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (spinal cord sulcus limitans) +AnnotationAssertion(Annotation( "OBOL:automatic") "A sulcus limitans of neural tube that is part of a future spinal cord.") +AnnotationAssertion( "EHDAA2:0001265") +AnnotationAssertion( "EMAPA:17584") +AnnotationAssertion( "VHOG:0001548") AnnotationAssertion(rdfs:label "spinal cord sulcus limitans") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38287,6 +60422,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (medulla oblongata sulcus limitans) +AnnotationAssertion(Annotation( "OBOL:automatic") "A sulcus limitans of neural tube that is part of a future medulla oblongata.") +AnnotationAssertion( "EHDAA2:0001100") +AnnotationAssertion( "EMAPA:17561") AnnotationAssertion(rdfs:label "medulla oblongata sulcus limitans") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38295,6 +60433,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (metencephalon sulcus limitans) +AnnotationAssertion(Annotation( "OBOL:automatic") "A sulcus limitans of neural tube that is part of a future metencephalon.") +AnnotationAssertion( "EHDAA2:0001161") +AnnotationAssertion( "EMAPA:17567") AnnotationAssertion(rdfs:label "metencephalon sulcus limitans") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38302,6 +60443,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (myelencephalon sulcus limitans) +AnnotationAssertion(Annotation( "OBOL:automatic") "A sulcus limitans of neural tube that is part of a future myelencephalon.") +AnnotationAssertion( "EHDAA2:0001945") AnnotationAssertion(rdfs:label "myelencephalon sulcus limitans") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38309,6 +60452,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (midbrain mantle layer) +AnnotationAssertion( "EHDAA2:0001172") +AnnotationAssertion( "EMAPA:16977") +AnnotationAssertion( "VHOG:0000910") AnnotationAssertion(rdfs:label "midbrain mantle layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38316,6 +60462,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (spinal cord mantle layer) +AnnotationAssertion( "EMAPA:17580") +AnnotationAssertion( "VHOG:0000911") AnnotationAssertion(rdfs:label "spinal cord mantle layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38323,6 +60471,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (1st arch mandibular mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a 1st arch mandibular component.") +AnnotationAssertion( "EHDAA2:0000034") +AnnotationAssertion( "EMAPA:16385") AnnotationAssertion(rdfs:label "1st arch mandibular mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38330,6 +60481,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left lung associated mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing left lung.") +AnnotationAssertion( "EHDAA2:0000944") +AnnotationAssertion( "EMAPA:16730") +AnnotationAssertion( "EMAPA:17654") AnnotationAssertion(rdfs:label "left lung associated mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38337,6 +60492,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right lung associated mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing right lung.") +AnnotationAssertion( "EHDAA2:0001739") +AnnotationAssertion( "EMAPA:17662") AnnotationAssertion(rdfs:label "right lung associated mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38344,6 +60502,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (midbrain neural plate) +AnnotationAssertion(Annotation( "OBOL:automatic") "A neural plate that develops_from a presumptive midbrain.") +AnnotationAssertion( "TAO:0007019") +AnnotationAssertion( "ZFA:0007019") AnnotationAssertion(rdfs:label "midbrain neural plate") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38351,6 +60512,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (hindbrain neural plate) +AnnotationAssertion(Annotation( "OBOL:automatic") "A neural plate that develops_from a presumptive hindbrain.") +AnnotationAssertion( "TAO:0007022") +AnnotationAssertion( "ZFA:0007022") AnnotationAssertion(rdfs:label "hindbrain neural plate") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38358,6 +60522,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (midbrain hindbrain boundary neural plate) +AnnotationAssertion( "TAO:0007044") +AnnotationAssertion( "ZFA:0007044") AnnotationAssertion(rdfs:label "midbrain hindbrain boundary neural plate") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38365,6 +60531,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (presumptive midbrain) +AnnotationAssertion(Annotation( "OBOL:automatic") "A presumptive structure that has the potential to develop into a midbrain.") +AnnotationAssertion( "BAMS:MES") +AnnotationAssertion( "EFO:0003432") +AnnotationAssertion( "EHDAA2:0000615") +AnnotationAssertion( "EMAPA:16140") +AnnotationAssertion( "TAO:0000148") +AnnotationAssertion( "Wikipedia:Mesencephalon") +AnnotationAssertion( "ZFA:0000148") AnnotationAssertion(rdfs:label "presumptive midbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38375,6 +60549,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (head paraxial mesoderm) +AnnotationAssertion(Annotation( "PMID:21610022") "Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles.") +AnnotationAssertion( "EHDAA2:0000736") +AnnotationAssertion( "EHDAA:364") +AnnotationAssertion( "EMAPA:16171") AnnotationAssertion(rdfs:label "head paraxial mesoderm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38382,19 +60560,35 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trunk paraxial mesoderm) +AnnotationAssertion( "EHDAA2:0002094") AnnotationAssertion(rdfs:label "trunk paraxial mesoderm") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (tail somite) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A somite that is part of a tail.") +AnnotationAssertion( "AAO:0010383") +AnnotationAssertion( "EMAPA:16860") +AnnotationAssertion( "XAO:0003143") +AnnotationAssertion(rdfs:label "tail somite") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (trachea non-cartilage connective tissue) -AnnotationAssertion( ) +AnnotationAssertion( "EMAPA:35878") +AnnotationAssertion( "MA:0001859") AnnotationAssertion(rdfs:label "trachea non-cartilage connective tissue") SubClassOf( ) # Class: (bronchus basement membrane) +AnnotationAssertion(Annotation( "OBOL:automatic") "A basement membrane that is part of a bronchus.") +AnnotationAssertion( "MA:0001832") +AnnotationAssertion( "NCIT:C49208") AnnotationAssertion(rdfs:label "bronchus basement membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38403,6 +60597,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trachea basement membrane) +AnnotationAssertion(Annotation( "OBOL:automatic") "A basement membrane that is part of a trachea.") +AnnotationAssertion( "MA:0001854") +AnnotationAssertion( "NCIT:C49302") AnnotationAssertion(rdfs:label "trachea basement membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38412,6 +60609,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (artery of lip) +AnnotationAssertion( "MA:0001987") +AnnotationAssertion( "NCIT:C52947") AnnotationAssertion(rdfs:label "artery of lip") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38419,6 +60618,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (midbrain nucleus) +AnnotationAssertion(Annotation( "ZFIN:curator") "Nucleus located in the midbrain.") +AnnotationAssertion( "SCTID:279285003") +AnnotationAssertion( "TAO:0002209") +AnnotationAssertion( "ZFA:0001665") AnnotationAssertion(rdfs:label "midbrain nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38426,13 +60629,80 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (hindbrain nucleus) +AnnotationAssertion(Annotation( "ZFIN:curator") "Nucleus located within the hindbrain.") +AnnotationAssertion( "TAO:0002177") +AnnotationAssertion( "ZFA:0001658") AnnotationAssertion(rdfs:label "hindbrain nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (gut mesentery) + +AnnotationAssertion( "EHDAA2:0004566") +AnnotationAssertion( "EMAPA:32911") +AnnotationAssertion( "MA:0003203") +AnnotationAssertion(rdfs:label "gut mesentery") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (embryonic cloacal lumen) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that surrounded_by a embryonic cloaca.") +AnnotationAssertion( "EHDAA2:0004586") +AnnotationAssertion(rdfs:label "embryonic cloacal lumen") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (rectal lumen) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that surrounded_by a rectum.") +AnnotationAssertion( "EHDAA2:0004587") +AnnotationAssertion( "EMAPA:18388") +AnnotationAssertion( "FMA:14598") +AnnotationAssertion( "SCTID:259740004") +AnnotationAssertion(rdfs:label "rectal lumen") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (dorsal pancreas) + +AnnotationAssertion( "EHDAA2:0001371") +AnnotationAssertion(rdfs:label "dorsal pancreas") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (ventral pancreas) + +AnnotationAssertion( "EHDAA2:0001393") +AnnotationAssertion(rdfs:label "ventral pancreas") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (endocardium of right ventricle) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any endocardium that is part of the right ventricle of the heart.") +AnnotationAssertion( "EHDAA2:0002188") +AnnotationAssertion( "EMAPA:17341") +AnnotationAssertion( "FMA:9536") +AnnotationAssertion( "NCIT:C102343") +AnnotationAssertion( "SCTID:8911002") +AnnotationAssertion( "VHOG:0001235") AnnotationAssertion(rdfs:label "endocardium of right ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38442,6 +60712,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endocardium of left ventricle) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any endocardium that is part of the left ventricle of the heart.") +AnnotationAssertion( "EHDAA2:0002182") +AnnotationAssertion( "EMAPA:17338") +AnnotationAssertion( "FMA:9559") +AnnotationAssertion( "SCTID:191004004") +AnnotationAssertion( "VHOG:0001233") AnnotationAssertion(rdfs:label "endocardium of left ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38450,6 +60726,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (stomodeal lumen) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that surrounded_by a stomodeum.") AnnotationAssertion(rdfs:label "stomodeal lumen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38457,6 +60734,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (entire pharyngeal arch endoderm) +AnnotationAssertion( "EHDAA2:0004621") +AnnotationAssertion( "EMAPA:32754") +AnnotationAssertion( "FMA:293087") AnnotationAssertion(rdfs:label "entire pharyngeal arch endoderm") SubClassOf( ) SubClassOf( ) @@ -38466,14 +60746,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac mesenchyme) +AnnotationAssertion(Annotation( "MP:0011264") "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures.") +AnnotationAssertion( "EHDAA2:0004162") +AnnotationAssertion( "EMAPA:36438") AnnotationAssertion(rdfs:label "cardiac mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreas mesenchyme) + +AnnotationAssertion(Annotation( "MP:0011265") "The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas.") +AnnotationAssertion( "EFO:0002557") +AnnotationAssertion( "EMAPA:26220") +AnnotationAssertion(rdfs:label "pancreas mesenchyme") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (abdominal ganglion) +AnnotationAssertion(Annotation( "OBOL:automatic") "A ganglion that is part of a abdominal segment of trunk.") +AnnotationAssertion( "SCTID:280508003") AnnotationAssertion(rdfs:label "abdominal ganglion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38481,6 +60776,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pleural sac) +AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/issues/86") "A serous sac that has the pleura and the pleural cavity as parts.") +AnnotationAssertion( "EHDAA2:0004737") +AnnotationAssertion( "FMA:9690") +AnnotationAssertion( "SCTID:361996004") AnnotationAssertion(rdfs:label "pleural sac") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38493,6 +60792,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (glandular acinus) +AnnotationAssertion(Annotation( "Wikipedia:Acinus") "The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form.") +AnnotationAssertion( "FMA:55588") +AnnotationAssertion( "Wikipedia:Acinus") AnnotationAssertion(rdfs:label "glandular acinus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38500,8 +60802,22 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (embryonic cloacal epithelium) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a embryonic cloaca.") +AnnotationAssertion( "EHDAA2:0004585") +AnnotationAssertion(rdfs:label "embryonic cloacal epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (digestive tract diverticulum) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "Branch or outpocketing of the digestive tract.") AnnotationAssertion(rdfs:label "digestive tract diverticulum") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38509,6 +60825,7 @@ SubClassOf( (sac) +AnnotationAssertion( "galen:Diverticulum") AnnotationAssertion(rdfs:label "sac") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38516,6 +60833,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (zone of stomach) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Stomach#Sections") "A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland.") +AnnotationAssertion( "EMAPA:35821") +AnnotationAssertion( "FMA:14558") +AnnotationAssertion( "MA:0002561") +AnnotationAssertion( "SCTID:245415005") +AnnotationAssertion( "Wikipedia:Stomach#Sections") AnnotationAssertion(rdfs:label "zone of stomach") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38524,6 +60847,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anterior lateral plate mesoderm) +AnnotationAssertion( "EFO:0003704") +AnnotationAssertion( "TAO:0005041") +AnnotationAssertion( "ZFA:0005041") AnnotationAssertion(rdfs:label "anterior lateral plate mesoderm") SubClassOf( ) SubClassOf( ) @@ -38531,6 +60857,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (secondary heart field) +AnnotationAssertion(Annotation( "GO:0003139") Annotation( "GOC:mtg_heart") Annotation( "GOC:rl") "A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).") +AnnotationAssertion( "XAO:0004186") AnnotationAssertion(rdfs:label "secondary heart field") SubClassOf( ) SubClassOf( ) @@ -38543,6 +60871,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (facial mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing face.") +AnnotationAssertion( "EMAPA:35337") +AnnotationAssertion( "FMA:302884") AnnotationAssertion(rdfs:label "facial mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38550,16 +60881,24 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lobule) +AnnotationAssertion( "FMA:45737") +AnnotationAssertion( "NCIT:C12990") AnnotationAssertion(rdfs:label "lobule") SubClassOf( ) # Class: (anatomical lobe) +AnnotationAssertion(Annotation( "ncithesaurus:Lobe") "A portion of an organ, such as the liver, lung, breast, or brain.") +AnnotationAssertion( "FMA:45728") +AnnotationAssertion( "NCIT:C13393") +AnnotationAssertion( "UMLS:C0796494") AnnotationAssertion(rdfs:label "anatomical lobe") SubClassOf( ) # Class: (optic neural crest) +AnnotationAssertion( "EHDAA2:0001315") +AnnotationAssertion( "EHDAA:1122") AnnotationAssertion(rdfs:label "optic neural crest") SubClassOf( ) SubClassOf( ) @@ -38567,6 +60906,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (post-embryonic organism) +AnnotationAssertion(Annotation( "OBOL:automatic") "A multicellular organism that existence_starts_with a post-embryonic stage.") +AnnotationAssertion( "MA:0002405") AnnotationAssertion(rdfs:label "post-embryonic organism") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38574,6 +60915,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neurogenic placode) +AnnotationAssertion(Annotation( "PMID:11523831") Annotation( "http://orcid.org/0000-0002-6601-2165") "Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia.") +AnnotationAssertion( "EFO:0003460") +AnnotationAssertion( "TAO:0001309") +AnnotationAssertion( "Wikipedia:Neurogenic_placodes") +AnnotationAssertion( "XAO:0004620") +AnnotationAssertion( "ZFA:0001309") AnnotationAssertion(rdfs:label "neurogenic placode") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38583,11 +60930,22 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) DisjointClasses( ) +# Class: (epithelium of pancreatic duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a pancreatic duct.") +AnnotationAssertion( "EFO:0002556") +AnnotationAssertion( "FMA:67681") +AnnotationAssertion(rdfs:label "epithelium of pancreatic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (multicellular anatomical structure) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0010000") "An anatomical structure that has more than one cell as a part.") +AnnotationAssertion( "CARO:0010000") AnnotationAssertion(rdfs:label "multicellular anatomical structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38596,6 +60954,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aggregate regional part of brain) +AnnotationAssertion(Annotation( "NLXANAT:20090509") "A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF].") +AnnotationAssertion( "NLXANAT:20090509") AnnotationAssertion(rdfs:label "aggregate regional part of brain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38604,6 +60964,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (6th arch mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a pharyngeal arch 6.") +AnnotationAssertion( "EHDAA2:0004076") +AnnotationAssertion( "EMAPA:32765") +AnnotationAssertion( "FMA:318209") AnnotationAssertion(rdfs:label "6th arch mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38611,6 +60975,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (food storage organ) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An organ of the digestive tract that is capable of retaining and storing food.") +AnnotationAssertion( "BSA:0000123") +AnnotationAssertion( "TADS:0000172") +AnnotationAssertion( "TGMA:0001041") AnnotationAssertion(rdfs:label "food storage organ") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38618,13 +60986,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (1st arch mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a pharyngeal arch 1.") +AnnotationAssertion( "EMAPA:16128") AnnotationAssertion(rdfs:label "1st arch mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (1st arch maxillary mesenchyme) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a 1st arch maxillary component.") +AnnotationAssertion( "EHDAA2:0000041") +AnnotationAssertion( "EMAPA:16391") +AnnotationAssertion(rdfs:label "1st arch maxillary mesenchyme") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (entire pharyngeal arch associated mesenchyme) +AnnotationAssertion(Annotation( "XAO:0004524") Annotation( "https://orcid.org/0000-0002-6601-2165") "The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells.") +AnnotationAssertion( "EHDAA2:0001459") +AnnotationAssertion( "EMAPA:16550") +AnnotationAssertion( "XAO:0004524") AnnotationAssertion(rdfs:label "entire pharyngeal arch associated mesenchyme") SubClassOf( ) SubClassOf( ) @@ -38633,6 +61017,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (oral gland) +AnnotationAssertion(Annotation( "ISBN:0073040584") "Gland of the epithelium lining the oral cavity. The most common are the salivary glands.") +AnnotationAssertion( "EHDAA2:0001327") +AnnotationAssertion( "EHDAA:2181") +AnnotationAssertion( "EMAPA:16572") +AnnotationAssertion( "EMAPA:16723") +AnnotationAssertion( "VHOG:0000652") AnnotationAssertion(rdfs:label "oral gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38641,11 +61031,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cuboidal epithelium) +AnnotationAssertion(Annotation( "Wikipedia:Cuboidal_epithelium") "An epithelium consisting of cuboidal epithelial cells.") +AnnotationAssertion( "NCIT:C32415") +AnnotationAssertion( "Wikipedia:Cuboidal_epithelium") AnnotationAssertion(rdfs:label "cuboidal epithelium") SubClassOf( ) +# Class: (future common hepatic duct) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An extrahepatic bile duct that has the potential to develop into a common hepatic duct.") +AnnotationAssertion( "EHDAA2:0000595") +AnnotationAssertion(rdfs:label "future common hepatic duct") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (future dermis) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that has the potential to develop into a dermis.") +AnnotationAssertion( "EHDAA2:0000598") AnnotationAssertion(rdfs:label "future dermis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38656,6 +61064,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future diaphragm) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A structure that will develop into a diaphragm.") +AnnotationAssertion( "EHDAA2:0000599") AnnotationAssertion(rdfs:label "future diaphragm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38666,6 +61076,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future metencephalon) +AnnotationAssertion(Annotation( "OBOL:automatic") "A developing anatomical structure that has the potential to develop into a metencephalon.") +AnnotationAssertion( "EHDAA2:0000623") AnnotationAssertion(rdfs:label "future metencephalon") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38674,6 +61086,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future myelencephalon) +AnnotationAssertion(Annotation( "OBOL:automatic") "A developing anatomical structure that has the potential to develop into a myelencephalon.") +AnnotationAssertion( "EHDAA2:0000640") AnnotationAssertion(rdfs:label "future myelencephalon") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38682,6 +61096,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future superior salivatory nucleus) +AnnotationAssertion(Annotation( "OBOL:automatic") "A gray matter that has the potential to develop into a superior salivatory nucleus.") +AnnotationAssertion( "EHDAA2:0004644") AnnotationAssertion(rdfs:label "future superior salivatory nucleus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38689,29 +61105,69 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (conducting tissue of heart) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers.") +AnnotationAssertion( "EHDAA2:0004528") +AnnotationAssertion( "FMA:83378") AnnotationAssertion(rdfs:label "conducting tissue of heart") SubClassOf( ) # Class: (epithelial sheet) +AnnotationAssertion(Annotation( "GO:0002011") "An epithelial sheet is a flat surface consisting of closely packed epithelial cells.") AnnotationAssertion(rdfs:label "epithelial sheet") SubClassOf( ) +# Class: (skin mucus) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A mucous secretion that is produced by glands in the epidermis.") +AnnotationAssertion(rdfs:label "skin mucus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (lumen of blood vessel) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that surrounded_by a blood vessel.") +AnnotationAssertion( "FMA:312610") +AnnotationAssertion( "SCTID:91747007") AnnotationAssertion(rdfs:label "lumen of blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (post-anal tail tip) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The distal end of the tail.") +AnnotationAssertion( "MA:0002848") +AnnotationAssertion( "XAO:0004057") +AnnotationAssertion(rdfs:label "post-anal tail tip") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (liver trabecula) + +AnnotationAssertion(Annotation( "GO:0060344") Annotation( "OBOL:automatic") "A trabecula that is part of a liver.") +AnnotationAssertion(rdfs:label "liver trabecula") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (protuberance) +AnnotationAssertion(Annotation( "EHDAA2:0003250") "A roughly circular bulge in a surface.") +AnnotationAssertion( "AEO:0000205") +AnnotationAssertion( "EHDAA2:0003250") +AnnotationAssertion( "FMA:82506") AnnotationAssertion(rdfs:label "protuberance") SubClassOf( ) # Class: (aortic system) +AnnotationAssertion( "EHDAA2:0004512") AnnotationAssertion(rdfs:label "aortic system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38719,18 +61175,47 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (genital artery) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Gonadal_artery") "One of the laterally paired arteries that supply the gonads.") +AnnotationAssertion( "Wikipedia:Gonadal_artery") AnnotationAssertion(rdfs:label "genital artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepatic portal system) + +AnnotationAssertion(Annotation( "ISBN:0073040584") "A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver.") +AnnotationAssertion( "AAO:0010225") +AnnotationAssertion(rdfs:label "hepatic portal system") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (bona-fide anatomical boundary) +AnnotationAssertion(Annotation( "CARO:0001004") "An anatomical boundary that corresponds to some physical discontinuity.") +AnnotationAssertion( "CARO:0001004") +AnnotationAssertion(rdfs:comment "One might argue that all boundaries are actually fiat in the sense that there must be some fiat element at a fine enough scale of granularity. This ontology choses to ignore this issue as below the level of granularity relevant to anatomy. (DOS121102)") AnnotationAssertion(rdfs:label "bona-fide anatomical boundary") SubClassOf( ) +# Class: (tail vasculature) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A vasculature that is part of a post-anal tail.") +AnnotationAssertion( "TAO:0005037") +AnnotationAssertion( "XAO:0004151") +AnnotationAssertion( "ZFA:0005037") +AnnotationAssertion(rdfs:label "tail vasculature") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (future cardiac atrium) +AnnotationAssertion(Annotation( "ZFA:0001718") "Multi-tissue structure that is part of the heart tube and will become the cardiac atrium.") +AnnotationAssertion( "FMA:71005") +AnnotationAssertion( "TAO:0002228") +AnnotationAssertion( "ZFA:0001718") AnnotationAssertion(rdfs:label "future cardiac atrium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38738,6 +61223,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (eyeball of camera-type eye) +AnnotationAssertion(Annotation( "UBERON:cjm") "The core globe-shaped component of the camera-type eye.") +AnnotationAssertion( "FMA:12513") +AnnotationAssertion( "MIAA:0000283") +AnnotationAssertion( "SCTID:244486005") +AnnotationAssertion( "VHOG:0001616") +AnnotationAssertion( "Wikipedia:Globe_(human_eye)") AnnotationAssertion(rdfs:label "eyeball of camera-type eye") SubClassOf( ) SubClassOf( ) @@ -38746,6 +61237,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (merocrine gland) +AnnotationAssertion(Annotation( "MGI:anna") Annotation( "MP:0013544") Annotation( "Wikipedia:Merocrine") "An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged.") +AnnotationAssertion( "BTO:0002324") +AnnotationAssertion( "MA:0003041") +AnnotationAssertion( "Wikipedia:Merocrine") AnnotationAssertion(rdfs:label "merocrine gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38753,6 +61248,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (1st arch mandibular mesenchyme from neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme.") +AnnotationAssertion( "EHDAA2:0000037") AnnotationAssertion(rdfs:label "1st arch mandibular mesenchyme from neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38761,8 +61258,23 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (1st arch maxillary mesenchyme from neural crest) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme.") +AnnotationAssertion( "EHDAA2:0000044") +AnnotationAssertion(rdfs:label "1st arch maxillary mesenchyme from neural crest") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (4th arch mesenchyme from neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme.") +AnnotationAssertion( "EHDAA2:0000098") +AnnotationAssertion( "EMAPA:16772") +AnnotationAssertion( "VHOG:0000580") AnnotationAssertion(rdfs:label "4th arch mesenchyme from neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38773,6 +61285,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (6th arch mesenchyme from neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme.") +AnnotationAssertion( "EHDAA2:0004077") AnnotationAssertion(rdfs:label "6th arch mesenchyme from neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38783,6 +61297,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesenchyme from rhombencephalic neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a rhombencephalon neural crest.") +AnnotationAssertion( "EHDAA2:0004423") AnnotationAssertion(rdfs:label "mesenchyme from rhombencephalic neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38791,6 +61307,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (1st arch mesenchyme from neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme.") +AnnotationAssertion( "EMAPA:16129") AnnotationAssertion(rdfs:label "1st arch mesenchyme from neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38798,8 +61316,23 @@ SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (space in vertebral column) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Any anatomical space that is part of a vertebral column.") +AnnotationAssertion( "AAO:0000700") +AnnotationAssertion(rdfs:label "space in vertebral column") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (midbrain basal plate) +AnnotationAssertion(Annotation( "ZFA:0000761") "Portion of tissue that is dorsolateral to the floor plate and part of the midbrain.") +AnnotationAssertion( "DHBA:12322") +AnnotationAssertion( "EFO:0003567") +AnnotationAssertion( "EHDAA2:0004375") +AnnotationAssertion( "TAO:0000761") +AnnotationAssertion( "ZFA:0000761") AnnotationAssertion(rdfs:label "midbrain basal plate") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38807,6 +61340,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (midbrain neural tube) +AnnotationAssertion(Annotation( "ZFA:0007039") "Portion of neural tube that gives rise to the midbrain.") +AnnotationAssertion( "TAO:0007039") +AnnotationAssertion( "ZFA:0007039") AnnotationAssertion(rdfs:label "midbrain neural tube") SubClassOf( ) SubClassOf( ) @@ -38814,6 +61350,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (layer of sclera) +AnnotationAssertion( "Wikipedia:Sclera#Histology") AnnotationAssertion(rdfs:label "layer of sclera") SubClassOf( ) SubClassOf( ) @@ -38821,6 +61358,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (scleral endothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An endothelium that is part of a sclera.") AnnotationAssertion(rdfs:label "scleral endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38829,6 +61367,10 @@ SubClassOf( (substantia propria of sclera) +AnnotationAssertion(Annotation( "OBOL:automatic") "A stroma that is part of a sclera.") +AnnotationAssertion( "FMA:58365") +AnnotationAssertion( "NCIT:C33652") +AnnotationAssertion( "SCTID:368851004") AnnotationAssertion(rdfs:label "substantia propria of sclera") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38836,6 +61378,7 @@ SubClassOf( (scleral mesenchyme) +AnnotationAssertion(Annotation( "PMID:16496288") Annotation( "https://orcid.org/0000-0002-6601-2165") "Mesenchyme surrounding the developing optic cup which develops into the sclera.") AnnotationAssertion(rdfs:label "scleral mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38844,6 +61387,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (extraembryonic epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a extraembryonic structure.") AnnotationAssertion(rdfs:label "extraembryonic epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38852,6 +61396,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (immature eye) +AnnotationAssertion(Annotation( "ZFA:0001678") "Developing anatomical structure that develops into the eyeball and associated structures.") +AnnotationAssertion( "TAO:0002201") +AnnotationAssertion( "ZFA:0001678") AnnotationAssertion(rdfs:label "immature eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38860,6 +61407,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural crest-derived structure) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An anatomical structure that develops from the neural crest.") AnnotationAssertion(rdfs:label "neural crest-derived structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38868,6 +61416,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (structure with developmental contribution from neural crest) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An anatomical structure that has some part that develops from the neural crest.") AnnotationAssertion(rdfs:label "structure with developmental contribution from neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38882,6 +61431,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skeletal element of eye region) +AnnotationAssertion(Annotation( "OBOL:automatic") "A skeletal element that is part of a orbital region.") AnnotationAssertion(rdfs:label "skeletal element of eye region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38891,6 +61441,14 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranial skeletal system) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000049") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.") +AnnotationAssertion( "AAO:0000109") +AnnotationAssertion( "AAO:0000971") +AnnotationAssertion( "AAO:0010185") +AnnotationAssertion( "TAO:0000737") +AnnotationAssertion( "VSAO:0000049") +AnnotationAssertion( "XAO:0003075") +AnnotationAssertion( "ZFA:0000737") AnnotationAssertion(rdfs:label "cranial skeletal system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38898,6 +61456,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (paired limb/fin bud mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a limb/fin bud.") AnnotationAssertion(rdfs:label "paired limb/fin bud mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38906,6 +61465,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (extraembryonic membrane mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a extraembryonic membrane.") AnnotationAssertion(rdfs:label "extraembryonic membrane mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38914,8 +61474,32 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (maxillary process mesenchyme from neural crest) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme.") +AnnotationAssertion( "EHDAA2:0004601") +AnnotationAssertion(rdfs:label "maxillary process mesenchyme from neural crest") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (maxillary process mesenchyme from head mesenchyme) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme.") +AnnotationAssertion( "EHDAA2:0004602") +AnnotationAssertion(rdfs:label "maxillary process mesenchyme from head mesenchyme") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mandibular process mesenchyme from neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme.") +AnnotationAssertion( "EHDAA2:0004603") AnnotationAssertion(rdfs:label "mandibular process mesenchyme from neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38925,6 +61509,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mandibular process mesenchyme from head mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme.") +AnnotationAssertion( "EHDAA2:0004604") AnnotationAssertion(rdfs:label "mandibular process mesenchyme from head mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38932,8 +61518,20 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (1st arch maxillary mesenchyme from head mesenchyme) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme.") +AnnotationAssertion( "EHDAA2:0000043") +AnnotationAssertion(rdfs:label "1st arch maxillary mesenchyme from head mesenchyme") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (1st arch mandibular mesenchyme from head mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme.") +AnnotationAssertion( "EHDAA2:0000036") AnnotationAssertion(rdfs:label "1st arch mandibular mesenchyme from head mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38942,6 +61540,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (1st arch mesenchyme from head mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme.") +AnnotationAssertion( "EMAPA:16130") AnnotationAssertion(rdfs:label "1st arch mesenchyme from head mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38951,6 +61551,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (4th arch mesenchyme from head mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme.") +AnnotationAssertion( "EHDAA2:0000097") +AnnotationAssertion( "EMAPA:16771") AnnotationAssertion(rdfs:label "4th arch mesenchyme from head mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38960,6 +61563,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (6th arch mesenchyme from head mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme.") +AnnotationAssertion( "EHDAA2:0004078") AnnotationAssertion(rdfs:label "6th arch mesenchyme from head mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38969,6 +61574,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch mesenchyme from neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme.") +AnnotationAssertion(rdfs:comment "Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme") AnnotationAssertion(rdfs:label "pharyngeal arch mesenchyme from neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38977,6 +61584,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch mesenchyme from head mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme.") +AnnotationAssertion(rdfs:comment "Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme") AnnotationAssertion(rdfs:label "pharyngeal arch mesenchyme from head mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -38987,6 +61596,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endoskeleton) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000037") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues.") +AnnotationAssertion( "VSAO:0000037") +AnnotationAssertion( "Wikipedia:Endoskeleton") +AnnotationAssertion( "XAO:0004026") AnnotationAssertion(rdfs:label "endoskeleton") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -38994,17 +61607,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endochondral element) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000139") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification.") +AnnotationAssertion( "VSAO:0000139") +AnnotationAssertion( "XAO:0004017") +AnnotationAssertion( "ZFA:0005620") AnnotationAssertion(rdfs:label "endochondral element") SubClassOf( ) # Class: (dermal skeleton) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000035") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements.") +AnnotationAssertion( "VSAO:0000035") +AnnotationAssertion( "XAO:0004025") +AnnotationAssertion(rdfs:comment "This ontology covers metazoa, so we do not use exoskeleton as primary label, as in VSAO") AnnotationAssertion(rdfs:label "dermal skeleton") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (pulmonary lobule) +AnnotationAssertion(Annotation( "ncithesaurus:Pulmonary_Lobule") "The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa.") +AnnotationAssertion( "FMA:75739") +AnnotationAssertion( "NCIT:C33428") AnnotationAssertion(rdfs:label "pulmonary lobule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39013,21 +61637,48 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (secondary pulmonary lobule) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "PMID:3259815") "A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa.") +AnnotationAssertion( "FMA:7414") AnnotationAssertion(rdfs:label "secondary pulmonary lobule") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (ecto-epithelium) +AnnotationAssertion(Annotation( "FMA:69064") "Epithelium composed of cells that develops from the ectoderm[FMA,modified].") +AnnotationAssertion( "FMA:69064") AnnotationAssertion(rdfs:label "ecto-epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreas dorsal primordium) + +AnnotationAssertion( "EHDAA2:0001384") +AnnotationAssertion( "FMA:79793") +AnnotationAssertion(rdfs:label "pancreas dorsal primordium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreas ventral primordium) + +AnnotationAssertion( "EHDAA2:0001387") +AnnotationAssertion( "FMA:79794") +AnnotationAssertion(rdfs:label "pancreas ventral primordium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (mesenchyme from somatopleure) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a somatopleure.") +AnnotationAssertion( "EHDAA2:0001120") AnnotationAssertion(rdfs:label "mesenchyme from somatopleure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39038,6 +61689,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesenchyme from splanchnopleure) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that develops_from a splanchnopleure.") +AnnotationAssertion( "EHDAA2:0001122") AnnotationAssertion(rdfs:label "mesenchyme from splanchnopleure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39046,8 +61699,38 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (spleen trabecular artery) + +AnnotationAssertion(Annotation( "MP:0002354") Annotation( "Wikipedia:Trabecular_arteries") "One of the branches of the splenic artery[MP].") +AnnotationAssertion( "MA:0000759") +AnnotationAssertion( "NCIT:C49775") +AnnotationAssertion( "Wikipedia:Trabecular_arteries") +AnnotationAssertion(rdfs:label "spleen trabecular artery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (spleen trabecular vein) + +AnnotationAssertion(Annotation( "MP:0002228") Annotation( "Wikipedia:Trabecular_veins") "One of the veins that feed the splenic vein.") +AnnotationAssertion( "MA:0000760") +AnnotationAssertion( "NCIT:C49779") +AnnotationAssertion( "Wikipedia:Trabecular_veins") +AnnotationAssertion(rdfs:label "spleen trabecular vein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (ocular surface region) +AnnotationAssertion(Annotation( "MP:0013754") "The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms.") +AnnotationAssertion( "EMAPA:35336") +AnnotationAssertion( "MA:0002486") AnnotationAssertion(rdfs:label "ocular surface region") SubClassOf( ) SubClassOf( ) @@ -39056,6 +61739,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ciliary processes) +AnnotationAssertion(Annotation( "Wikipedia:Ciliary_processes") "The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens.") +AnnotationAssertion( "FMA:76551") +AnnotationAssertion( "SCTID:280860001") +AnnotationAssertion( "Wikipedia:Ciliary_processes") AnnotationAssertion(rdfs:label "ciliary processes") SubClassOf( ) SubClassOf( ) @@ -39063,17 +61750,32 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (flat bone) +AnnotationAssertion(Annotation( "Wikipedia:Flat_bone") "A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow.") +AnnotationAssertion( "FMA:7476") +AnnotationAssertion( "NCIT:C32616") +AnnotationAssertion( "SCTID:332907008") +AnnotationAssertion( "Wikipedia:Flat_bone") +AnnotationAssertion( "galen:FlatBone") +AnnotationAssertion(rdfs:comment "Examples: cranium, the ilium, sternum, rib cage, the sacrum and the scapula; the occipital, parietal, frontal, nasal, lacrimal, vomer, scapula, os coxC&, sternum, and ribs") AnnotationAssertion(rdfs:label "flat bone") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (pseudostratified columnar epithelium) +AnnotationAssertion(Annotation( "Wikipedia:Pseudostratified_columnar_epithelium") Annotation( "http://medical-dictionary.thefreedictionary.com/pseudostratified+epithelium") "A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels.") +AnnotationAssertion( "FMA:45572") +AnnotationAssertion( "NCIT:C33419") +AnnotationAssertion( "NCIT:C49316") +AnnotationAssertion( "Wikipedia:Pseudostratified_columnar_epithelium") AnnotationAssertion(rdfs:label "pseudostratified columnar epithelium") SubClassOf( ) # Class: (pseudostratified ciliated columnar epithelium) +AnnotationAssertion(Annotation( "NCIT:NCIT") "Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile.") +AnnotationAssertion( "FMA:13146") +AnnotationAssertion( "NCIT:C13181") AnnotationAssertion(rdfs:label "pseudostratified ciliated columnar epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39081,18 +61783,45 @@ SubClassOf( (replacement element) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000135") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Skeletal element that forms as a replacement or substitution of another element or tissue.") +AnnotationAssertion( "VSAO:0000135") +AnnotationAssertion( "XAO:0004016") +AnnotationAssertion( "ZFA:0005624") AnnotationAssertion(rdfs:label "replacement element") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (microcirculatory vessel) +AnnotationAssertion(Annotation( "MESH:A07.231.432") Annotation( "ZFA:0005251") Annotation( "http://orcid.org/0000-0002-6601-2165") "A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses.") +AnnotationAssertion( "MESH:D055806") +AnnotationAssertion( "TAO:0005251") +AnnotationAssertion( "ZFA:0005251") AnnotationAssertion(rdfs:label "microcirculatory vessel") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (cavity of bone organ) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An organ cavity that surrounded_by a bone.") +AnnotationAssertion( "FMA:24021") +AnnotationAssertion(rdfs:label "cavity of bone organ") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pneumatic cavity of bone) + +AnnotationAssertion( "FMA:24028") +AnnotationAssertion(rdfs:label "pneumatic cavity of bone") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (appendage girdle complex) +AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/wiki/Appendages-and-the-appendicular-skeleton") Annotation( "https://orcid.org/0000-0002-6601-2165") "An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).") +AnnotationAssertion( "FMA:7182") +AnnotationAssertion( "VSAO:0000214") AnnotationAssertion(rdfs:label "appendage girdle complex") SubClassOf( ) SubClassOf( ) @@ -39102,6 +61831,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral complex) +AnnotationAssertion(Annotation( "VSAO:0000213") "Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle.") +AnnotationAssertion( "FMA:7183") +AnnotationAssertion( "SCTID:110716002") +AnnotationAssertion( "VSAO:0000213") AnnotationAssertion(rdfs:label "pectoral complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39110,6 +61843,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (girdle skeleton) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "The subdivision of the skeleton of either the pectoral or pelvic girdle.") +AnnotationAssertion( "AAO:0010686") +AnnotationAssertion( "VSAO:0000302") AnnotationAssertion(rdfs:label "girdle skeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39120,6 +61856,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bone of appendage girdle complex) +AnnotationAssertion(Annotation( "UBERONREF:0000003") Annotation( "https://orcid.org/0000-0002-6601-2165") "A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle).") +AnnotationAssertion( "EMAPA:35494") +AnnotationAssertion( "MA:0000688") AnnotationAssertion(rdfs:label "bone of appendage girdle complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39129,6 +61868,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bone of pectoral complex) +AnnotationAssertion(Annotation( "UBERONREF:0000003") Annotation( "https://orcid.org/0000-0002-6601-2165") "A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin.") +AnnotationAssertion( "EMAPA:35933") +AnnotationAssertion( "MA:0000612") AnnotationAssertion(rdfs:label "bone of pectoral complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39136,6 +61878,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral complex muscle) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A muscle of a pectoral girdle, pectoral fin or anterior limb.") +AnnotationAssertion( "AAO:0010687") +AnnotationAssertion( "EMAPA:32624") +AnnotationAssertion( "FMA:9621") +AnnotationAssertion( "MA:0000615") AnnotationAssertion(rdfs:label "pectoral complex muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39143,13 +61890,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (subdivision of skeleton) +AnnotationAssertion(Annotation( "UBERONREF:0000003") Annotation( "https://orcid.org/0000-0002-6601-2165") "Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.") +AnnotationAssertion( "FMA:23879") +AnnotationAssertion( "SCTID:129140006") +AnnotationAssertion( "VSAO:0000042") AnnotationAssertion(rdfs:label "subdivision of skeleton") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (vertebral element) + +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "VSAO:0000184") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "https://github.com/obophenotype/uberon/issues/294") "Skeletal element that forms around the notochord and is part of the vertebral column.") +AnnotationAssertion( "VHOG:0001143") +AnnotationAssertion( "VSAO:0000184") +AnnotationAssertion(rdfs:label "vertebral element") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (craniocervical muscle) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any muscle organ that is part of either the head or the neck.") +AnnotationAssertion( "NCIT:C32716") AnnotationAssertion(rdfs:label "craniocervical muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39157,14 +61919,57 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch cartilage) +AnnotationAssertion(Annotation( "OBOL:automatic") "A cartilage element that is part of a splanchnocranium.") +AnnotationAssertion( "EFO:0003689") +AnnotationAssertion( "TAO:0001460") +AnnotationAssertion( "ZFA:0001460") AnnotationAssertion(rdfs:label "pharyngeal arch cartilage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (palatoquadrate arch) + +AnnotationAssertion(Annotation( "VHOG:0000511") Annotation( "https://github.com/obophenotype/uberon/issues/153") "The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG].") +AnnotationAssertion( "EFO:0003659") +AnnotationAssertion( "TAO:0001272") +AnnotationAssertion( "ZFA:0001272") +AnnotationAssertion(rdfs:label "palatoquadrate arch") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (vertebra cartilage element) + +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "VSAO:0000184") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "http://orcid.org/0000-0002-6601-2165") "The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.") +AnnotationAssertion( "EMAPA:32669") +AnnotationAssertion( "VHOG:0000584") +AnnotationAssertion(rdfs:label "vertebra cartilage element") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (vertebra pre-cartilage condensation) + +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "VSAO:0000184") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "http://orcid.org/0000-0002-6601-2165") "The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.") +AnnotationAssertion( "EMAPA:32671") +AnnotationAssertion( "VHOG:0000582") +AnnotationAssertion(rdfs:label "vertebra pre-cartilage condensation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (synovial joint of pectoral girdle) +AnnotationAssertion(Annotation( "OBOL:automatic") "A synovial joint that is part of a pectoral girdle region.") +AnnotationAssertion( "FMA:35243") +AnnotationAssertion( "SCTID:303080001") AnnotationAssertion(rdfs:label "synovial joint of pectoral girdle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39174,23 +61979,47 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nonsynovial joint) +AnnotationAssertion(Annotation( "FMA:7491") "Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis.") +AnnotationAssertion( "FMA:7491") AnnotationAssertion(rdfs:label "nonsynovial joint") SubClassOf( ) # Class: (axial skeletal system) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints.") +AnnotationAssertion( "FMA:7483") AnnotationAssertion(rdfs:label "axial skeletal system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (postcranial axial skeletal system) +AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/issues/44") Annotation( "https://orcid.org/0000-0002-6601-2165") "Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.") +AnnotationAssertion( "FMA:302077") AnnotationAssertion(rdfs:label "postcranial axial skeletal system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (submucosal gland) + +AnnotationAssertion(Annotation( "BTO:0003751") Annotation( "Wikipedia:Submucosal_glands") "Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue.") +AnnotationAssertion( "BTO:0003751") +AnnotationAssertion( "Wikipedia:Submucosal_glands") +AnnotationAssertion(rdfs:label "submucosal gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (facial skeleton) +AnnotationAssertion(Annotation( "MP:0005274") Annotation( "Wikipedia:Facial_skeleton") Annotation( "http://www.bartleby.com/107/37.html") Annotation( "https://orcid.org/0000-0002-6601-2165") "Subdivision of skull that consists of the facial bones.") +AnnotationAssertion( "EHDAA2:0002206") +AnnotationAssertion( "EHDAA:8361") +AnnotationAssertion( "EMAPA:18022") +AnnotationAssertion( "FMA:53673") +AnnotationAssertion( "MA:0000318") +AnnotationAssertion( "Wikipedia:Facial_skeleton") AnnotationAssertion(rdfs:label "facial skeleton") SubClassOf( ) SubClassOf( ) @@ -39198,6 +62027,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (primary subdivision of skull) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The skull can be divided into two: the neurocranium and the facial skeleton.") +AnnotationAssertion( "FMA:54964") AnnotationAssertion(rdfs:label "primary subdivision of skull") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -39210,14 +62041,70 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neurocranium bone) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone that is part of a neurocranium [Automatically generated definition].") +AnnotationAssertion( "EMAPA:35238") +AnnotationAssertion( "MA:0001478") +AnnotationAssertion( "SCTID:120229002") AnnotationAssertion(rdfs:label "neurocranium bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (joint connecting upper and lower jaws) + +AnnotationAssertion(Annotation( "http://evolution.berkeley.edu/evolibrary/article/evograms_05") Annotation( "https://orcid.org/0000-0002-6601-2165") "Synovial joint that articulates bones of upper and lower jaw.") +AnnotationAssertion(rdfs:label "joint connecting upper and lower jaws") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (gastrointestinal sphincter) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A sphincter muscle that is part of the gastrointestinal system.") +AnnotationAssertion( "NCIT:C32669") +AnnotationAssertion(rdfs:label "gastrointestinal sphincter") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (lamina propria of large intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A lamina propria that is part of a large intestine.") +AnnotationAssertion( "FMA:15654") +AnnotationAssertion( "NCIT:C49298") +AnnotationAssertion(rdfs:label "lamina propria of large intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (muscle layer of large intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscle layer that is part of a large intestine.") +AnnotationAssertion( "FMA:14971") +AnnotationAssertion( "NCIT:C32927") +AnnotationAssertion(rdfs:label "muscle layer of large intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (muscle layer of small intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscle layer that is part of a small intestine.") +AnnotationAssertion( "FMA:14932") +AnnotationAssertion( "NCIT:C33569") +AnnotationAssertion( "SCTID:362145004") +AnnotationAssertion(rdfs:label "muscle layer of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (central nervous system cell part cluster) +AnnotationAssertion(Annotation( "OBOL:automatic") "A multi cell part structure that is part of a central nervous system.") +AnnotationAssertion( "FMA:83143") AnnotationAssertion(rdfs:label "central nervous system cell part cluster") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39226,16 +62113,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (organ system subdivision) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A subdivision of an anatomical system.") +AnnotationAssertion( "FMA:67509") +AnnotationAssertion( "SCTID:91690000") AnnotationAssertion(rdfs:label "organ system subdivision") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (intra-ocular muscle) +AnnotationAssertion( "AAO:0010038") +AnnotationAssertion( "EMAPA:18808") +AnnotationAssertion( "FMA:49150") AnnotationAssertion(rdfs:label "intra-ocular muscle") SubClassOf( ) SubClassOf( ) @@ -39243,6 +62132,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (synovial membrane of synovial tendon sheath) +AnnotationAssertion(Annotation( "FMA:45087") Annotation( "Wikipedia:Synovial_sheath") "Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa.") +AnnotationAssertion( "BTO:0001823") +AnnotationAssertion( "FMA:40878") +AnnotationAssertion( "Wikipedia:Synovial_sheath") +AnnotationAssertion(rdfs:comment "Alternate def: A synovial sheath is a layer of a tendon sheath containing tendons in the hand and foot. They lie internal to the fibrous tendon sheaths. An example is the common synovial sheath for the flexor tendons. [Wikipedia:Synovial_sheath]") AnnotationAssertion(rdfs:label "synovial membrane of synovial tendon sheath") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39250,14 +62144,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (fibrous membrane of synovial tendon sheath) +AnnotationAssertion( "FMA:40877") AnnotationAssertion(rdfs:label "fibrous membrane of synovial tendon sheath") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (ethmoid region) + +AnnotationAssertion(Annotation( "UBERONREF:0000007") Annotation( "http://palaeos.com/vertebrates/bones/braincase/ethmoid.html") "The most anterior region of the braincase. Provides structural support for peripheral olfactory organ.") +AnnotationAssertion( "AAO:0000986") +AnnotationAssertion(rdfs:label "ethmoid region") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (appendicular skeletal system) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints.") +AnnotationAssertion( "FMA:7484") +AnnotationAssertion( "VSAO:0000306") AnnotationAssertion(rdfs:label "appendicular skeletal system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -39265,12 +62172,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dorsal trunk) +AnnotationAssertion(Annotation( "UBERONREF:0000006") Annotation( "Wikipedia:Human_back") "The part of the trunk that is in the dorsum[cjm].") +AnnotationAssertion( "EMAPA:35162") +AnnotationAssertion( "FMA:25056") +AnnotationAssertion( "MA:0000020") +AnnotationAssertion( "Wikipedia:Human_back") AnnotationAssertion(rdfs:label "dorsal trunk") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (embryonic skin basal layer) +AnnotationAssertion( "EHDAA2:0001845") AnnotationAssertion(rdfs:label "embryonic skin basal layer") SubClassOf( ) SubClassOf( ) @@ -39279,6 +62192,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranial blood vasculature) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vasculature that is part of a head.") +AnnotationAssertion( "TAO:0005297") +AnnotationAssertion( "ZFA:0005297") AnnotationAssertion(rdfs:label "cranial blood vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39286,12 +62202,18 @@ SubClassOf( (lumen of gastrointestinal system) +AnnotationAssertion( "FMA:54364") +AnnotationAssertion( "SCTID:432899004") AnnotationAssertion(rdfs:label "lumen of gastrointestinal system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (lumen of esophagus) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that is part of a esophagus.") +AnnotationAssertion( "EMAPA:18380") +AnnotationAssertion( "FMA:9398") +AnnotationAssertion( "SCTID:322648002") AnnotationAssertion(rdfs:label "lumen of esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39301,6 +62223,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (paired limb/fin skeleton) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "The collection of all skeletal elements in an individual limb or fin.") +AnnotationAssertion( "VSAO:0000301") AnnotationAssertion(rdfs:label "paired limb/fin skeleton") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39312,11 +62236,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cell condensation) +AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000006") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995).") +AnnotationAssertion( "VSAO:0000006") +AnnotationAssertion( "XAO:0004021") AnnotationAssertion(rdfs:label "cell condensation") SubClassOf( ) +# Class: (future upper lip) + +AnnotationAssertion( "EHDAA2:0002120") +AnnotationAssertion(rdfs:label "future upper lip") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (jaw region) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions.") +AnnotationAssertion( "EMAPA:32905") +AnnotationAssertion( "NCIT:C114916") AnnotationAssertion(rdfs:label "jaw region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39327,13 +62266,24 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future lower lip) +AnnotationAssertion( "EHDAA2:0001020") AnnotationAssertion(rdfs:label "future lower lip") SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (bone of upper jaw) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species).") +AnnotationAssertion(rdfs:label "bone of upper jaw") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (oral epithelium from ectoderm) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that develops_from a ectoderm and is part of a oral epithelium.") +AnnotationAssertion( "EHDAA2:0004137") AnnotationAssertion(rdfs:label "oral epithelium from ectoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39344,18 +62294,38 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (jaw muscle) +AnnotationAssertion( "AAO:0000247") +AnnotationAssertion( "EFO:0003511") +AnnotationAssertion( "TAO:0000236") +AnnotationAssertion( "XAO:0003269") +AnnotationAssertion( "ZFA:0000236") AnnotationAssertion(rdfs:label "jaw muscle") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (subdivision of organism along main body axis) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column.") AnnotationAssertion(rdfs:label "subdivision of organism along main body axis") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (trunk vertebra) + +AnnotationAssertion(Annotation( "UBERONREF:0000006") "A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly.") +AnnotationAssertion(rdfs:label "trunk vertebra") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (embryonic cardiovascular system) +AnnotationAssertion(Annotation( "OBOL:automatic") "A cardiovascular system that is part of a conceptus.") +AnnotationAssertion( "EHDAA2:0000216") +AnnotationAssertion( "FMA:305965") +AnnotationAssertion( "NCIT:C34148") AnnotationAssertion(rdfs:label "embryonic cardiovascular system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39363,14 +62333,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lower jaw opening) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that is part of a bone of lower jaw.") +AnnotationAssertion( "AAO:0000273") AnnotationAssertion(rdfs:label "lower jaw opening") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (upper jaw opening) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that is part of a bone of upper jaw.") +AnnotationAssertion( "AAO:0000621") +AnnotationAssertion(rdfs:label "upper jaw opening") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (nucleus of spinal cord) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A neural nucleus that is part of the spinal cord.") +AnnotationAssertion( "FMA:77011") AnnotationAssertion(rdfs:label "nucleus of spinal cord") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39378,6 +62362,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nerve of head region) +AnnotationAssertion(Annotation( "OBOL:automatic") "A nerve that is part of a head.") AnnotationAssertion(rdfs:label "nerve of head region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39385,12 +62370,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (non-neurogenic ectodermal placode) +AnnotationAssertion(Annotation( "PMID:11523831") Annotation( "http://orcid.org/0000-0002-6601-2165") "Ectodermal placode that does not develop into a component of the nervous system.") AnnotationAssertion(rdfs:label "non-neurogenic ectodermal placode") SubClassOf( ) # Class: (atrioventricular region) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart.") +AnnotationAssertion( "EHDAA2:0004149") +AnnotationAssertion( "FMA:85125") AnnotationAssertion(rdfs:label "atrioventricular region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39401,11 +62389,17 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (irregular connective tissue) +AnnotationAssertion(Annotation( "FMA:20107") "Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium.") +AnnotationAssertion( "FMA:20107") AnnotationAssertion(rdfs:label "irregular connective tissue") SubClassOf( ) # Class: (dense irregular connective tissue) +AnnotationAssertion(Annotation( "FMA:20109") Annotation( "Wikipedia:Dense_irregular_connective_tissue") "Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium.") +AnnotationAssertion( "FMA:20109") +AnnotationAssertion( "NCIT:C32882") +AnnotationAssertion( "Wikipedia:Dense_irregular_connective_tissue") AnnotationAssertion(rdfs:label "dense irregular connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39414,6 +62408,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (dense connective tissue) +AnnotationAssertion(Annotation( "Wikipedia:Dense_connective_tissue") "Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets.") +AnnotationAssertion( "AAO:0000121") +AnnotationAssertion( "NCIT:C32450") +AnnotationAssertion( "Wikipedia:Dense_connective_tissue") AnnotationAssertion(rdfs:label "dense connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39422,16 +62420,23 @@ DisjointClasses( (fibrous connective tissue) +AnnotationAssertion( "FMA:75634") +AnnotationAssertion( "SCTID:363130003") AnnotationAssertion(rdfs:label "fibrous connective tissue") SubClassOf( ) # Class: (loose connective tissue) +AnnotationAssertion(Annotation( "FMA:19783") "Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue.") +AnnotationAssertion( "FMA:19783") +AnnotationAssertion( "NCIT:C33007") +AnnotationAssertion( "Wikipedia:Loose_connective_tissue") AnnotationAssertion(rdfs:label "loose connective tissue") SubClassOf( ) # Class: (acinus of exocrine gland) +AnnotationAssertion(Annotation( "OBOL:automatic") "An acinus that is part of a exocrine gland.") AnnotationAssertion(rdfs:label "acinus of exocrine gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39439,6 +62444,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (collection of collagen fibrils) +AnnotationAssertion( "FMA:63212") +AnnotationAssertion( "MESH:D024022") +AnnotationAssertion( "NCIT:C32339") +AnnotationAssertion( "NIF_Subcellular:sao7547390221") AnnotationAssertion(rdfs:label "collection of collagen fibrils") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -39446,6 +62455,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aorta collagen fibril) +AnnotationAssertion(Annotation( "MP:0011640") "The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity.") AnnotationAssertion(rdfs:label "aorta collagen fibril") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39455,6 +62465,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pulmonary collagen fibril) +AnnotationAssertion(Annotation( "MP:0011641") "The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity.") AnnotationAssertion(rdfs:label "pulmonary collagen fibril") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39464,6 +62475,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (bone collagen fibril) +AnnotationAssertion(Annotation( "MP:0011642") "The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity.") AnnotationAssertion(rdfs:label "bone collagen fibril") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39471,6 +62483,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tendon collagen fibril) +AnnotationAssertion(Annotation( "MP:0011643") "The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity.") AnnotationAssertion(rdfs:label "tendon collagen fibril") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39479,6 +62492,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (corneal stroma collagen fibril) +AnnotationAssertion(Annotation( "MP:0011650") "The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity.") AnnotationAssertion(rdfs:label "corneal stroma collagen fibril") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39486,8 +62500,20 @@ SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (muscle layer of esophagus) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscle layer that is part of a wall of esophagus.") +AnnotationAssertion( "FMA:62998") +AnnotationAssertion(rdfs:label "muscle layer of esophagus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (anterior uvea) +AnnotationAssertion(Annotation( "MP:0005194") "Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris.") +AnnotationAssertion( "SCTID:280656002") AnnotationAssertion(rdfs:label "anterior uvea") SubClassOf( ) SubClassOf( ) @@ -39499,6 +62525,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epimysium) +AnnotationAssertion(Annotation( "Wikipedia:Epimysium") "Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous.") +AnnotationAssertion( "FMA:9726") +AnnotationAssertion( "NCIT:C32527") +AnnotationAssertion( "Wikipedia:Epimysium") AnnotationAssertion(rdfs:label "epimysium") SubClassOf( ) SubClassOf( ) @@ -39508,6 +62538,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (yolk sac blood island) +AnnotationAssertion(Annotation( "MP:0011204") "Masses of developing blood cells attached to endothelium in the yolk sac.") +AnnotationAssertion( "EHDAA2:0000177") +AnnotationAssertion( "EMAPA:16115") AnnotationAssertion(rdfs:label "yolk sac blood island") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39517,32 +62550,89 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (stomach glandular region) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A region of the stomach that is lined with glandular epithelium.") +AnnotationAssertion( "EMAPA:17623") +AnnotationAssertion( "MA:0001613") +AnnotationAssertion( "NCIT:C77661") +AnnotationAssertion( "SCTID:27633001") AnnotationAssertion(rdfs:label "stomach glandular region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (left hepatic vein) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A hepatic vein that is part of a left lobe of liver.") +AnnotationAssertion( "FMA:14339") +AnnotationAssertion( "MA:0003032") +AnnotationAssertion( "SCTID:55188000") +AnnotationAssertion(rdfs:label "left hepatic vein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (right hepatic vein) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A hepatic vein that is part of a right lobe of liver.") +AnnotationAssertion( "FMA:14338") +AnnotationAssertion( "MA:0003034") +AnnotationAssertion( "SCTID:18135006") +AnnotationAssertion(rdfs:label "right hepatic vein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (coelom) +AnnotationAssertion(Annotation( "UBERON:cjm") Annotation( "Wikipedia:Body_cavity") Annotation( "Wikipedia:Coelom") "The aggregate of the coelemic cavity lumen plus the membranes that line the lumen.") +AnnotationAssertion( "EHDAA2:0004731") +AnnotationAssertion( "Wikipedia:Coelom") AnnotationAssertion(rdfs:label "coelom") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (myocoele) +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/myocoele") "The cavity within a myotome.") +AnnotationAssertion( "EMAPA:31134") +AnnotationAssertion( "VHOG:0001283") AnnotationAssertion(rdfs:label "myocoele") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (palate bone) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "Any bone that is part of a palate.") +AnnotationAssertion( "NCIT:C33248") +AnnotationAssertion(rdfs:label "palate bone") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (palatal part of dermatocranium) + +AnnotationAssertion(rdfs:label "palatal part of dermatocranium") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (replacement bone) +AnnotationAssertion(Annotation( "ZFA:0001628") "Bone that forms as a replacement of another structural tissue.") +AnnotationAssertion( "AAO:0010768") +AnnotationAssertion( "TAO:0001637") +AnnotationAssertion( "ZFA:0001628") AnnotationAssertion(rdfs:label "replacement bone") SubClassOf( ) SubClassOf( ) # Class: (bronchial lumen) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical cavity that is part of a bronchus.") +AnnotationAssertion( "FMA:62646") +AnnotationAssertion( "SCTID:199401001") AnnotationAssertion(rdfs:label "bronchial lumen") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -39550,6 +62640,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (stomach primordium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A primordium that has the potential to develop into a stomach.") +AnnotationAssertion( "EFO:0002580") +AnnotationAssertion( "NCIT:C34305") AnnotationAssertion(rdfs:label "stomach primordium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39558,6 +62651,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (head or neck skin) +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a craniocervical region.") +AnnotationAssertion( "MA:0000574") +AnnotationAssertion( "NCIT:C12294") AnnotationAssertion(rdfs:label "head or neck skin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39565,6 +62661,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (phrenic vein) +AnnotationAssertion(Annotation( "ncithesaurus:Phrenic_Vein") "The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins.") +AnnotationAssertion( "MA:0002194") +AnnotationAssertion( "NCIT:C53062") AnnotationAssertion(rdfs:label "phrenic vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39572,6 +62671,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdominal aorta artery) +AnnotationAssertion(Annotation( "Wikipedia:Abdominal_aorta#Branches") Annotation( "https://orcid.org/0000-0002-6601-2165") "An artery that originates from the abdominal aorta.") +AnnotationAssertion( "SCTID:281470000") AnnotationAssertion(rdfs:label "abdominal aorta artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39579,12 +62680,16 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (columnar epithelium) +AnnotationAssertion(Annotation( "Wikipedia:Columnar_epithelium") "An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified].") +AnnotationAssertion( "Wikipedia:Columnar_epithelium") AnnotationAssertion(rdfs:label "columnar epithelium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (meso-epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "Epithelium that derives from the mesoderm. [Automatically generated definition].") +AnnotationAssertion( "FMA:86452") AnnotationAssertion(rdfs:label "meso-epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39592,6 +62697,9 @@ SubClassOf( (embryonic facial prominence) +AnnotationAssertion(Annotation( "http://www.indiana.edu/~anat550/hnanim/face/face.html") "One of five swellings formed during the development of the face.") +AnnotationAssertion( "FMA:293103") +AnnotationAssertion( "SCTID:89066004") AnnotationAssertion(rdfs:label "embryonic facial prominence") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -39599,6 +62707,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cervical artery) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "An artery of the neck.") +AnnotationAssertion( "NCIT:C52850") AnnotationAssertion(rdfs:label "cervical artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39606,7 +62716,10 @@ SubClassOf( (deep cervical artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Deep_cervical_artery") "The deep cervical artery (Profunda cervicalis) is an artery of the neck.") +AnnotationAssertion( "FMA:10659") +AnnotationAssertion( "SCTID:244223002") +AnnotationAssertion( "Wikipedia:Deep_cervical_artery") AnnotationAssertion(rdfs:label "deep cervical artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39615,21 +62728,50 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (transverse cervical artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Transverse_cervical_artery") "The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery.") +AnnotationAssertion( "FMA:10664") +AnnotationAssertion( "MA:0001936") +AnnotationAssertion( "SCTID:244224008") +AnnotationAssertion( "Wikipedia:Transverse_cervical_artery") AnnotationAssertion(rdfs:label "transverse cervical artery") SubClassOf( ) # Class: (bone of jaw) +AnnotationAssertion(Annotation( "OBOL:automatic") "A bone element that is part of a jaw region.") +AnnotationAssertion( "EMAPA:35453") +AnnotationAssertion( "MA:0003130") +AnnotationAssertion( "SCTID:369003004") AnnotationAssertion(rdfs:label "bone of jaw") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (internal anal region) + +AnnotationAssertion( "EHDAA2:0004588") +AnnotationAssertion(rdfs:label "internal anal region") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (muscle layer of intestine) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscle layer that is part of an intestine.") +AnnotationAssertion( "FMA:15697") +AnnotationAssertion(rdfs:label "muscle layer of intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (subserosa) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Subserosa") "A layer of tissue between the muscularis and serosa.") +AnnotationAssertion( "FMA:45636") +AnnotationAssertion( "NCIT:C94494") +AnnotationAssertion( "SCTID:2255006") +AnnotationAssertion( "Wikipedia:Subserosa") +AnnotationAssertion(rdfs:comment "Contains nerves, blood vessels, lymphatics and lymph nodes") AnnotationAssertion(rdfs:label "subserosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39639,7 +62781,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system arterial smooth muscle) -AnnotationAssertion( ) +AnnotationAssertion( "MA:0001802") AnnotationAssertion(rdfs:label "respiratory system arterial smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39648,14 +62790,39 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system venous smooth muscle) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A smooth muscle tissue that is part of a respiratory system venous blood vessel.") +AnnotationAssertion( "MA:0001812") AnnotationAssertion(rdfs:label "respiratory system venous smooth muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (layer of microvilli) + +AnnotationAssertion(Annotation( "GO:0005902") Annotation( "Wikipedia:Microvillus") "A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified].") +AnnotationAssertion( "FMA:67296") +AnnotationAssertion( "MESH:D008871") +AnnotationAssertion( "NCIT:C33112") +AnnotationAssertion( "Wikipedia:Microvillus") +AnnotationAssertion(rdfs:label "layer of microvilli") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (striated border microvillus layer) + +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/striated+border") Annotation( "http://orcid.org/0000-0002-6601-2165") "A microvillus layer that is striated and found in the intestine.") +AnnotationAssertion( "FMA:70978") +AnnotationAssertion( "NCIT:C33634") +AnnotationAssertion(rdfs:label "striated border microvillus layer") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (hematopoietic tissue) +AnnotationAssertion(Annotation( "http://encyclopedia2.thefreedictionary.com/hematopoietic+tissue") "Blood-forming tissue, consisting of reticular fibers and cells.") +AnnotationAssertion( "CALOHA:TS-2142") +AnnotationAssertion( "FMA:14073") +AnnotationAssertion( "NCIT:C13051") AnnotationAssertion(rdfs:label "hematopoietic tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39665,6 +62832,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tunica fibrosa of eyeball) +AnnotationAssertion(Annotation( "Wikipedia:Fibrous_tunic_of_eyeball") "The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth.") +AnnotationAssertion( "FMA:58102") +AnnotationAssertion( "SCTID:361318005") +AnnotationAssertion( "Wikipedia:Fibrous_tunic_of_eyeball") AnnotationAssertion(rdfs:label "tunica fibrosa of eyeball") SubClassOf( ) SubClassOf( ) @@ -39673,8 +62844,40 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (cloacal lumen) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that is enclosed by a cloaca.") +AnnotationAssertion( "TAO:0000330") +AnnotationAssertion( "ZFA:0000330") +AnnotationAssertion(rdfs:label "cloacal lumen") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (cloacal vent) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives.") +AnnotationAssertion(rdfs:label "cloacal vent") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (lumen of terminal part of digestive tract) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that is enclosed by a terminal part of digestive tract.") +AnnotationAssertion(rdfs:label "lumen of terminal part of digestive tract") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (extraembryonic cavity) +AnnotationAssertion( "EHDAA2:0000472") +AnnotationAssertion( "EMAPA:16054") +AnnotationAssertion( "VHOG:0000767") AnnotationAssertion(rdfs:label "extraembryonic cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39682,13 +62885,24 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (enclosed anatomical space) +AnnotationAssertion(Annotation( "AEO:0000222") "An anatomical space with no opening to another space or to the exterior.") +AnnotationAssertion( "AEO:0000222") AnnotationAssertion(rdfs:label "enclosed anatomical space") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (external anal region) + +AnnotationAssertion( "EHDAA2:0004589") +AnnotationAssertion(rdfs:label "external anal region") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (skeleton of pectoral complex) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle.") +AnnotationAssertion( "FMA:24139") AnnotationAssertion(rdfs:label "skeleton of pectoral complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39696,15 +62910,146 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (dorsal part of neck) + +AnnotationAssertion(Annotation( "MP:0012723") "The posterior region of the neck, including the suboccipital region.") +AnnotationAssertion( "BTO:0000957") +AnnotationAssertion( "FMA:24189") +AnnotationAssertion( "SCTID:182326009") +AnnotationAssertion( "SCTID:304036007") +AnnotationAssertion(rdfs:label "dorsal part of neck") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (cloacal gland) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A gland that is part of a cloaca.") +AnnotationAssertion(rdfs:label "cloacal gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (cloacal mucosa) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a cloaca [Automatically generated definition].") +AnnotationAssertion(rdfs:label "cloacal mucosa") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (cloacal epithelium) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An epithelium that is part of a cloaca.") +AnnotationAssertion( "EMAPA:27577") +AnnotationAssertion( "EMAPA:36070") +AnnotationAssertion( "ZFA:0005783") +AnnotationAssertion(rdfs:label "cloacal epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (submucosa of cloaca) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A submucosa that is part of a cloaca [Automatically generated definition].") +AnnotationAssertion(rdfs:label "submucosa of cloaca") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (serosa of cloaca) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A serous membrane that is part of a cloaca [Automatically generated definition].") +AnnotationAssertion(rdfs:label "serosa of cloaca") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (cloacal villus) + +AnnotationAssertion(rdfs:label "cloacal villus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (muscle layer of cloaca) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscular coat that is part of a cloaca.") +AnnotationAssertion(rdfs:label "muscle layer of cloaca") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (muscle layer of duodenum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscular coat that is part of a duodenum.") +AnnotationAssertion( "FMA:14944") +AnnotationAssertion( "SCTID:362147007") +AnnotationAssertion(rdfs:label "muscle layer of duodenum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (muscle layer of colon) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscular coat that is part of a colon.") +AnnotationAssertion( "EMAPA:27383") +AnnotationAssertion( "FMA:14986") +AnnotationAssertion( "MA:0003198") +AnnotationAssertion( "SCTID:362158003") +AnnotationAssertion(rdfs:label "muscle layer of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (muscle layer of anal canal) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscular coat that is part of a anal canal.") +AnnotationAssertion( "FMA:15708") +AnnotationAssertion( "SCTID:362171000") +AnnotationAssertion(rdfs:label "muscle layer of anal canal") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (adventitia of esophagus) +AnnotationAssertion(Annotation( "OBOL:automatic") "An adventitia that is part of a esophagus.") +AnnotationAssertion( "FMA:63006") +AnnotationAssertion( "SCTID:85950006") AnnotationAssertion(rdfs:label "adventitia of esophagus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (gastroduodenal junction) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical junction that connects a stomach and connects a duodenum.") +AnnotationAssertion( "FMA:17046") +AnnotationAssertion( "SCTID:264014000") +AnnotationAssertion(rdfs:label "gastroduodenal junction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (mucosa of gastroduodenal junction) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a gastroduodenal junction.") +AnnotationAssertion( "BTO:0005415") +AnnotationAssertion(rdfs:label "mucosa of gastroduodenal junction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vein of abdomen) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vein that is part of a abdomen.") +AnnotationAssertion( "SCTID:281473003") AnnotationAssertion(rdfs:label "vein of abdomen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39712,6 +63057,8 @@ SubClassOf( (pulmonary venous system) +AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Pulmonary_venous_system") "The part of the venous system that drains the lungs[Kardong].") +AnnotationAssertion( "Wikipedia:Pulmonary_venous_system") AnnotationAssertion(rdfs:label "pulmonary venous system") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -39719,6 +63066,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vein of lip) +AnnotationAssertion(Annotation( "OBOL:automatic") "A vein that drains a lip.") +AnnotationAssertion( "SCTID:367664002") AnnotationAssertion(rdfs:label "vein of lip") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39727,13 +63076,37 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (systemic vein) +AnnotationAssertion(Annotation( "ncithesaurus:Systemic_Vein") "Any vein within the general circulation that transports blood back to the right atrium of the heart.") +AnnotationAssertion( "FMA:66644") +AnnotationAssertion( "NCIT:C33719") +AnnotationAssertion( "SCTID:244389004") AnnotationAssertion(rdfs:label "systemic vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (foregut-midgut junction gland) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A gland that is part of a foregut-midgut junction.") +AnnotationAssertion( "EHDAA2:0000574") +AnnotationAssertion( "EMAPA:17065") +AnnotationAssertion(rdfs:label "foregut-midgut junction gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (anal sac gland secretion) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A bodily secretion that is produced by a gland of anal sac.") +AnnotationAssertion(rdfs:label "anal sac gland secretion") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (serous acinus) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "http://www.siumed.edu/~dking2/intro/glands.htm") "The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells.") +AnnotationAssertion( "FMA:86279") AnnotationAssertion(rdfs:label "serous acinus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39742,6 +63115,13 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranial cavity) +AnnotationAssertion(Annotation( "UBERON:cjm") "Anatomical cavity that is the lumen of the skull and contains the brain.") +AnnotationAssertion( "FMA:9644") +AnnotationAssertion( "MA:0003061") +AnnotationAssertion( "NCIT:C77638") +AnnotationAssertion( "SCTID:264452006") +AnnotationAssertion( "Wikipedia:Cranial_cavity") +AnnotationAssertion( "neuronames:2806") AnnotationAssertion(rdfs:label "cranial cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39750,14 +63130,91 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung endothelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel endothelium that is part of a lung [Automatically generated definition].") +AnnotationAssertion( "BTO:0004128") +AnnotationAssertion( "CALOHA:TS-0573") AnnotationAssertion(rdfs:label "lung endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ) +# Class: (cloacal sphincter) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A sphincter muscle that is part of a cloaca.") +AnnotationAssertion( "NCIT:C34129") +AnnotationAssertion(rdfs:comment "the muscles of the cloacal sphincter specialise into the perineal muscles in mammals (Gegenbaur, 1883; Popowsky, 1899; Nishi, 1938).") +AnnotationAssertion(rdfs:label "cloacal sphincter") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (caudal vertebra cartilage element) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A caudal vertebra endochondral element that is composed primarily of cartilage tissue.") +AnnotationAssertion( "EHDAA2:0000260") +AnnotationAssertion( "EMAPA:18044") +AnnotationAssertion(rdfs:label "caudal vertebra cartilage element") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (caudal vertebra pre-cartilage condensation) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation.") +AnnotationAssertion( "EMAPA:18045") +AnnotationAssertion(rdfs:label "caudal vertebra pre-cartilage condensation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (cervical vertebra cartilage element) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A cervical vertebra endochondral element that is composed primarily of cartilage tissue.") +AnnotationAssertion( "EHDAA2:0000240") +AnnotationAssertion(rdfs:label "cervical vertebra cartilage element") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (cervical vertebra pre-cartilage condensation) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation.") +AnnotationAssertion(rdfs:label "cervical vertebra pre-cartilage condensation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (thoracic vertebra cartilage element) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A thoracic vertebra endochondral element that is composed primarily of cartilage tissue.") +AnnotationAssertion( "EHDAA2:0002014") +AnnotationAssertion(rdfs:label "thoracic vertebra cartilage element") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (thoracic vertebra pre-cartilage condensation) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation.") +AnnotationAssertion(rdfs:label "thoracic vertebra pre-cartilage condensation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (space surrounding organism) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "The space that surrounds an organism.") AnnotationAssertion(rdfs:label "space surrounding organism") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39774,14 +63231,31 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (stomach lumen) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The anatomical space that is enclosed by a stomach.") +AnnotationAssertion( "EMAPA:18395") +AnnotationAssertion( "FMA:14585") AnnotationAssertion(rdfs:label "stomach lumen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelium of intestinal villus) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a intestinal villus.") +AnnotationAssertion( "FMA:63587") +AnnotationAssertion(rdfs:label "epithelium of intestinal villus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (foramen of skull) +AnnotationAssertion(Annotation( "TAO:curator") Annotation( "http://orcid.org/0000-0002-6601-2165") "Anatomical space that is an opening in a bone of the skull.") +AnnotationAssertion( "FMA:53165") +AnnotationAssertion( "SCTID:276742007") +AnnotationAssertion( "Wikipedia:Foramina_of_the_skull") AnnotationAssertion(rdfs:label "foramen of skull") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39789,9 +63263,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anatomical conduit space) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FMA:9338") Annotation( "http://orcid.org/0000-0002-6601-2165") "An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified].") +AnnotationAssertion( "FMA:9338") AnnotationAssertion(rdfs:label "anatomical conduit space") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -39799,14 +63272,39 @@ SubClassOf( ObjectExactCardinalit # Class: (brain endothelium) +AnnotationAssertion(Annotation( "CALOHA:TS-0092") "Vascular endothelium found in blood vessels of the blood-brain-barrier.") +AnnotationAssertion( "BTO:0001852") +AnnotationAssertion( "BTO:0003248") +AnnotationAssertion( "CALOHA:TS-0092") AnnotationAssertion(rdfs:label "brain endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (colon endothelium) + +AnnotationAssertion(Annotation( "CALOHA:TS-0162") "Vascular endothelium found in colon blood vessels.") +AnnotationAssertion( "CALOHA:TS-0162") +AnnotationAssertion(rdfs:label "colon endothelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (exocrine pancreas epithelium) + +AnnotationAssertion(Annotation( "CALOHA:TS-2108") "Epithelium lining the exocrine pancreas.") +AnnotationAssertion( "CALOHA:TS-2108") +AnnotationAssertion(rdfs:label "exocrine pancreas epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (axial musculature) +AnnotationAssertion(Annotation( "HP:0003327") "Musculature of the head and neck, spine, and ribs.") +AnnotationAssertion( "EHDAA2:0000159") +AnnotationAssertion( "EMAPA:18166") AnnotationAssertion(rdfs:label "axial musculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39815,18 +63313,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (main body axis) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages.") AnnotationAssertion(rdfs:label "main body axis") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (body proper) +AnnotationAssertion(Annotation( "AEO:0000103") "The region of the organism associated with the visceral organs.") +AnnotationAssertion( "AEO:0000103") +AnnotationAssertion( "BTO:0001489") +AnnotationAssertion( "FMA:231424") AnnotationAssertion(rdfs:label "body proper") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (notochordal canal) +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/notochordal+canal") "A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily.") +AnnotationAssertion( "FMA:293127") +AnnotationAssertion( "NCIT:C34230") AnnotationAssertion(rdfs:label "notochordal canal") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39835,6 +63341,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (notochordal fluid) +AnnotationAssertion(Annotation( "http://animaldiversity.org/accounts/Latimeria_chalumnae/") Annotation( "http://orcid.org/0000-0002-6601-2165") "Fluid contained within the notochordal canal.") +AnnotationAssertion(rdfs:comment "Distinct feature of coelocanths") AnnotationAssertion(rdfs:label "notochordal fluid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39843,6 +63351,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (integumentary system layer) +AnnotationAssertion(Annotation( "OBOL:automatic") "An organ component layer that is part of a integumental system.") +AnnotationAssertion( "SCTID:314820002") AnnotationAssertion(rdfs:label "integumentary system layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39850,6 +63360,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (arterial blood) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood that is part of a artery.") +AnnotationAssertion( "FMA:83066") AnnotationAssertion(rdfs:label "arterial blood") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39857,6 +63369,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (venous blood) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood that is part of a vein.") +AnnotationAssertion( "FMA:83067") AnnotationAssertion(rdfs:label "venous blood") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39864,6 +63378,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (capillary blood) +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood that is part of a capillary.") +AnnotationAssertion( "FMA:263901") +AnnotationAssertion( "NCIT:C32212") AnnotationAssertion(rdfs:label "capillary blood") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39871,6 +63388,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (digestive system element) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements.") +AnnotationAssertion( "SCTID:272627002") AnnotationAssertion(rdfs:label "digestive system element") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39878,11 +63397,19 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (great vessel of heart) +AnnotationAssertion(Annotation( "Wikipedia:Great_vessels") "Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart.") +AnnotationAssertion( "EMAPA:36460") +AnnotationAssertion( "SCTID:304066000") +AnnotationAssertion( "Wikipedia:Great_vessels") +AnnotationAssertion(rdfs:comment "Groupings may vary - typically pulmonary vessels and aorta and vena cavae") AnnotationAssertion(rdfs:label "great vessel of heart") SubClassOf( ) # Class: (mesenchyme derived from neural crest) +AnnotationAssertion(Annotation( "OBOL:automatic") Annotation( "https://github.com/obophenotype/uberon/issues/248") "Mesenchyme that develops_from the neural crest[Automatically generated definition].") +AnnotationAssertion( "EMAPA:32735") +AnnotationAssertion( "FMA:293883") AnnotationAssertion(rdfs:label "mesenchyme derived from neural crest") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39890,6 +63417,7 @@ SubClassOf( (respiratory muscle) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Muscle that is part of the respiratory system.") AnnotationAssertion(rdfs:label "respiratory muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39898,14 +63426,28 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sinusoidal space) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that is enclosed by a sinusoid.") +AnnotationAssertion( "FMA:63133") AnnotationAssertion(rdfs:label "sinusoidal space") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (hepatic sinusoidal space) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A sinusoidal space that is part of a hepatic sinusoid.") +AnnotationAssertion( "FMA:262090") +AnnotationAssertion(rdfs:label "hepatic sinusoidal space") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (sex-specific anatomical structure) +AnnotationAssertion(Annotation( "AEO:0000174") Annotation( "AEO:JB") "A part of the body present only in a specific gender.") +AnnotationAssertion( "AEO:0000174") +AnnotationAssertion( "WBbt:0005752") AnnotationAssertion(rdfs:label "sex-specific anatomical structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39913,6 +63455,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (female anatomical structure) +AnnotationAssertion(Annotation( "AEO:0000176") Annotation( "AEO:JB") "A part of the body present only in females.") +AnnotationAssertion( "AEO:0000176") AnnotationAssertion(rdfs:label "female anatomical structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39920,6 +63464,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (visceral abdominal adipose tissue) +AnnotationAssertion(Annotation( "CALOHA:paula") Annotation( "MGI:csmith") Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/259") "Subcutaneous adipose tissue that is located in the peritoneal cavity.") +AnnotationAssertion( "BTO:0004041") +AnnotationAssertion( "CALOHA:TS-2405") AnnotationAssertion(rdfs:label "visceral abdominal adipose tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39928,6 +63475,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (subcutaneous abdominal adipose tissue) +AnnotationAssertion(Annotation( "CALOHA:paula") Annotation( "MGI:csmith") Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/259") "Subcutaneous adipose tissue that is located in the abdominal region.") +AnnotationAssertion( "CALOHA:TS-2406") AnnotationAssertion(rdfs:label "subcutaneous abdominal adipose tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39935,7 +63484,10 @@ SubClassOf( (thoracic skeleton) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Rib_cage") Annotation( "https://orcid.org/0000-0002-6601-2165") "Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum.") +AnnotationAssertion( "EHDAA2:0002013") +AnnotationAssertion( "FMA:77169") +AnnotationAssertion( "Wikipedia:Thoracic_skeleton") AnnotationAssertion(rdfs:label "thoracic skeleton") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -39943,7 +63495,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic spinal cord ventral horn) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A ventral horn of spinal cord that is part of a thoracic spinal cord.") +AnnotationAssertion( "BIRNLEX:1410") +AnnotationAssertion( "SCTID:367876000") AnnotationAssertion(rdfs:label "thoracic spinal cord ventral horn") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39951,7 +63505,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cervical spinal cord gray matter) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A gray matter of spinal cord that is part of a cervical spinal cord.") +AnnotationAssertion( "BIRNLEX:1521") +AnnotationAssertion( "SCTID:362438009") AnnotationAssertion(rdfs:label "cervical spinal cord gray matter") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39959,7 +63515,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cervical spinal cord ventral horn) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A ventral horn of spinal cord that is part of a cervical spinal cord.") +AnnotationAssertion( "BIRNLEX:1680") +AnnotationAssertion( "SCTID:174363005") AnnotationAssertion(rdfs:label "cervical spinal cord ventral horn") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39967,14 +63525,43 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (thoracic spinal cord gray matter) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A gray matter of spinal cord that is part of a thoracic spinal cord.") +AnnotationAssertion( "BIRNLEX:980") +AnnotationAssertion( "SCTID:362441000") AnnotationAssertion(rdfs:label "thoracic spinal cord gray matter") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (frontonasal process epithelium) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a frontonasal prominence.") +AnnotationAssertion( "EHDAA2:0004108") +AnnotationAssertion( "EMAPA:32918") +AnnotationAssertion(rdfs:label "frontonasal process epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (anal membrane ectodermal component) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A unilaminar epithelium that develops_from a ectoderm and is part of a anal region.") +AnnotationAssertion( "EHDAA2:0004019") +AnnotationAssertion( "EMAPA:25040") +AnnotationAssertion(rdfs:label "anal membrane ectodermal component") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (pleuroperitoneal canal lumen) +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that is enclosed by a pleuroperitoneal canal.") +AnnotationAssertion( "EHDAA2:0004736") +AnnotationAssertion( "EMAPA:25034") AnnotationAssertion(rdfs:label "pleuroperitoneal canal lumen") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -39983,16 +63570,30 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (interlobular duct) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ncithesaurus:Interlobular_Duct") "A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory.") +AnnotationAssertion( "NCIT:C32828") +AnnotationAssertion( "UMLS:C1512857") +AnnotationAssertion( "Wikipedia:Interlobular_ducts") AnnotationAssertion(rdfs:label "interlobular duct") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mucous acinus) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "http://www.siumed.edu/~dking2/intro/glands.htm") "The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells.") +AnnotationAssertion( "FMA:86278") +AnnotationAssertion(rdfs:label "mucous acinus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (intralobular duct) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://www.siumed.edu/~dking2/intro/glands.htm") "A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular.") +AnnotationAssertion( "SCTID:205214009") AnnotationAssertion(rdfs:label "intralobular duct") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40000,6 +63601,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (interlobar duct) +AnnotationAssertion(Annotation( "http://www.siumed.edu/~dking2/intro/glands.htm") "A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory.") AnnotationAssertion(rdfs:label "interlobar duct") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40008,6 +63610,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (midbrain neuromere) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A neuromere that is part of the presumptive midbrain.") +AnnotationAssertion( "EHDAA2:0004352") +AnnotationAssertion( "FMA:61997") AnnotationAssertion(rdfs:label "midbrain neuromere") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40015,13 +63620,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (spinal neuromere) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A neuromere that is part of the presumptive spinal cord.") +AnnotationAssertion( "TAO:0001332") +AnnotationAssertion( "ZFA:0001332") AnnotationAssertion(rdfs:label "spinal neuromere") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (cloacal muscle) + +AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a cloaca.") +AnnotationAssertion(rdfs:label "cloacal muscle") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (musculature of pectoral complex) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin.") +AnnotationAssertion( "FMA:71296") AnnotationAssertion(rdfs:label "musculature of pectoral complex") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40029,6 +63648,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage muscle) +AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin).") AnnotationAssertion(rdfs:label "pectoral appendage muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40036,7 +63656,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skeletal muscle organ, vertebrate) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GOC:dos") "A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles).") +AnnotationAssertion( "AAO:0011099") +AnnotationAssertion( "BTO:0001103") +AnnotationAssertion( "CALOHA:TS-0933") +AnnotationAssertion( "EFO:0000888") +AnnotationAssertion( "EHDAA:5035") +AnnotationAssertion( "EHDAA:5043") +AnnotationAssertion( "EHDAA:5978") +AnnotationAssertion( "EHDAA:5984") +AnnotationAssertion( "EMAPA:35988") +AnnotationAssertion( "EV:0100377") +AnnotationAssertion( "GAID:141") +AnnotationAssertion( "MA:0003148") +AnnotationAssertion( "MAT:0000302") +AnnotationAssertion( "MESH:D018482") +AnnotationAssertion( "MIAA:0000302") +AnnotationAssertion( "TAO:0005277") +AnnotationAssertion( "VHOG:0000319") +AnnotationAssertion( "XAO:0000174") +AnnotationAssertion( "ZFA:0005277") AnnotationAssertion(rdfs:label "skeletal muscle organ, vertebrate") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40049,6 +63688,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (primordial vasculature) +AnnotationAssertion(Annotation( "ZFA:0005076") Annotation( "ZFA:curator") "A portion of tissue that will develop into vasculature.") +AnnotationAssertion( "EFO:0003708") +AnnotationAssertion( "TAO:0005076") +AnnotationAssertion( "ZFA:0005076") AnnotationAssertion(rdfs:label "primordial vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40057,18 +63700,56 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (intersomitic vessel) +AnnotationAssertion(Annotation( "MGI:anna") "One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites.") +AnnotationAssertion( "EFO:0003664") +AnnotationAssertion( "TAO:0001285") +AnnotationAssertion( "XAO:0004075") +AnnotationAssertion( "ZFA:0001285") AnnotationAssertion(rdfs:label "intersomitic vessel") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (cervical vertebra endochondral element) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A vertebral endochondral element in the cervical region of the vertebral column.") +AnnotationAssertion(rdfs:label "cervical vertebra endochondral element") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +EquivalentClasses( ObjectUnionOf( )) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (thoracic vertebra endochondral element) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A vertebral endochondral element in the thoracic region of the vertebral column.") +AnnotationAssertion(rdfs:label "thoracic vertebra endochondral element") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +EquivalentClasses( ObjectUnionOf( )) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (sphenoid endochondral element) + +AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern") "A sphenoid bone or its cartilage or pre-cartilage precursor.") +AnnotationAssertion(rdfs:label "sphenoid endochondral element") +EquivalentClasses( ObjectUnionOf( )) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (subepicardial layer of epicardium) +AnnotationAssertion( "FMA:83105") AnnotationAssertion(rdfs:label "subepicardial layer of epicardium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (epicardial fat) +AnnotationAssertion(Annotation( "DOI:10.5935/abc.20130138") "Visceral intrapericardial fat contiguous with the myocardial surface.") +AnnotationAssertion( "FMA:9871") AnnotationAssertion(rdfs:label "epicardial fat") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40081,6 +63762,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gland of ocular region) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/614") "A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands.") AnnotationAssertion(rdfs:label "gland of ocular region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40088,6 +63770,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (multi-unit eye) +AnnotationAssertion(Annotation( "PMID:21062451") Annotation( "http://orcid.org/0000-0002-6601-2165") "An eye consisting of multiple light-sensing organs.") AnnotationAssertion(rdfs:label "multi-unit eye") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40095,6 +63778,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (somite border) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A region of somite adjacent to presomitic mesoderm.") +AnnotationAssertion( "TAO:0001462") +AnnotationAssertion( "XAO:0004074") +AnnotationAssertion( "ZFA:0001462") AnnotationAssertion(rdfs:label "somite border") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40103,6 +63790,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (somite boundary epithelium) +AnnotationAssertion(Annotation( "XAO:0004077") Annotation( "XAO:EJS") "Epithelium located in the intersomitic region.") +AnnotationAssertion( "XAO:0004077") AnnotationAssertion(rdfs:label "somite boundary epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40110,11 +63799,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (non-connected functional system) +AnnotationAssertion(Annotation( "AEO:0000093") Annotation( "AEO:JB") Annotation( "FBC:DOS") Annotation( "FBbt:00007278") "An anatomical group whose component structures share a common function.") +AnnotationAssertion( "AEO:0000093") AnnotationAssertion(rdfs:label "non-connected functional system") SubClassOf( ) # Class: (glandular system) +AnnotationAssertion(Annotation( "OBOL:automatic") "A non-connected functional system that is composed primarily of a gland.") +AnnotationAssertion( "EHDAA2:0002223") AnnotationAssertion(rdfs:label "glandular system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40122,6 +63815,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lateral structure) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any structure that is placed on one side of the left-right axis of a bilaterian.") AnnotationAssertion(rdfs:label "lateral structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40130,13 +63824,36 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (circulatory organ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile.") AnnotationAssertion(rdfs:label "circulatory organ") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (pancreas left lobe) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A pancreatic lobule that is in_the_left_side_of a exocrine pancreas.") +AnnotationAssertion( "MA:0000722") +AnnotationAssertion(rdfs:label "pancreas left lobe") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreas right lobe) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A pancreatic lobule that is in_the_right_side_of a exocrine pancreas.") +AnnotationAssertion( "MA:0000723") +AnnotationAssertion(rdfs:label "pancreas right lobe") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (respiratory system basement membrane) +AnnotationAssertion(Annotation( "OBOL:automatic") "A basement membrane of epithelium that is part of a respiratory system.") +AnnotationAssertion( "MA:0001815") AnnotationAssertion(rdfs:label "respiratory system basement membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40144,25 +63861,98 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart plus pericardium) -AnnotationAssertion( ) +AnnotationAssertion( "MA:0002449") AnnotationAssertion(rdfs:label "heart plus pericardium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (proper hepatic artery) + +AnnotationAssertion(Annotation( "Wikipedia:Hepatic_artery_proper") "The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery.") +AnnotationAssertion( "FMA:14772") +AnnotationAssertion( "MA:0003095") +AnnotationAssertion( "SCTID:244262006") +AnnotationAssertion( "Wikipedia:Hepatic_artery_proper") +AnnotationAssertion(rdfs:label "proper hepatic artery") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (left hepatic artery) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A hepatic artery that is part of a left lobe of liver.") +AnnotationAssertion( "FMA:14779") +AnnotationAssertion( "MA:0003096") +AnnotationAssertion(rdfs:label "left hepatic artery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (right hepatic artery) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A hepatic artery that is part of a right lobe of liver.") +AnnotationAssertion( "FMA:14778") +AnnotationAssertion( "MA:0003097") +AnnotationAssertion(rdfs:label "right hepatic artery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (choledocho-duodenal junction) + +AnnotationAssertion(Annotation( "http://medical-dictionary.thefreedictionary.com/choledochoduodenal+junction") "Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla.") +AnnotationAssertion( "MA:0003108") +AnnotationAssertion(rdfs:label "choledocho-duodenal junction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (anal canal epithelium) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a anal canal.") +AnnotationAssertion( "EMAPA:18835") +AnnotationAssertion( "FMA:17511") +AnnotationAssertion(rdfs:label "anal canal epithelium") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (heterogeneous tissue) +AnnotationAssertion( "FMA:62798") AnnotationAssertion(rdfs:label "heterogeneous tissue") SubClassOf( ) # Class: (smooth muscle layer in fatty layer of subcutaneous tissue) +AnnotationAssertion(Annotation( "OBOL:automatic") "A smooth muscle tissue that is part of a hypodermis.") +AnnotationAssertion( "FMA:77862") AnnotationAssertion(rdfs:label "smooth muscle layer in fatty layer of subcutaneous tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (liver blood vessel) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a liver.") +AnnotationAssertion( "EMAPA:35498") +AnnotationAssertion( "MA:0003137") +AnnotationAssertion(rdfs:label "liver blood vessel") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (eye epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a camera-type eye.") +AnnotationAssertion( "EMAPA:35957") +AnnotationAssertion( "MA:0003162") AnnotationAssertion(rdfs:label "eye epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40171,14 +63961,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (foregut epithelium) +AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a foregut.") +AnnotationAssertion( "EMAPA:32922") +AnnotationAssertion( "MA:0003204") AnnotationAssertion(rdfs:label "foregut epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (duodenum lamina propria) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A lamina propria that is part of a duodenum.") +AnnotationAssertion( "EMAPA:27255") +AnnotationAssertion( "FMA:15972") +AnnotationAssertion( "MA:0003209") +AnnotationAssertion(rdfs:label "duodenum lamina propria") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (pulmonary capillary) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "OBOL:automatic") "A capillary that is part of a lung.") +AnnotationAssertion( "FMA:14121") AnnotationAssertion(rdfs:label "pulmonary capillary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40186,14 +63991,34 @@ SubClassOf( (esophageal hiatus) +AnnotationAssertion(Annotation( "HP:0002036") "A hole in the diaphragm through which the esophagus passes.") +AnnotationAssertion( "FMA:58289") AnnotationAssertion(rdfs:label "esophageal hiatus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (liver stroma) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A stroma that is part of a liver.") +AnnotationAssertion( "FMA:17553") +AnnotationAssertion(rdfs:label "liver stroma") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (auditory system) +AnnotationAssertion(Annotation( "NLXANAT:090817") "Is the sensory system for the sense of hearing.") +AnnotationAssertion( "EMAPA:36002") +AnnotationAssertion( "FMA:7192") +AnnotationAssertion( "MA:0002443") +AnnotationAssertion( "NCIT:C12889") +AnnotationAssertion( "NLXANAT:090817") +AnnotationAssertion( "Wikipedia:Auditory_system") +AnnotationAssertion( "neuronames:2888") AnnotationAssertion(rdfs:label "auditory system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40202,13 +64027,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cavity of right ventricle) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Luminal space of the right ventricle of the heart.") +AnnotationAssertion( "EMAPA:26047") +AnnotationAssertion( "FMA:9291") AnnotationAssertion(rdfs:label "cavity of right ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (lumen of duodenum) + +AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that is part of a duodenum.") +AnnotationAssertion( "EMAPA:19080") +AnnotationAssertion( "FMA:14589") +AnnotationAssertion(rdfs:label "lumen of duodenum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (cavity of left atrium) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Luminal space of the left atrium of the heart.") +AnnotationAssertion( "EMAPA:26011") +AnnotationAssertion( "FMA:9465") AnnotationAssertion(rdfs:label "cavity of left atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40216,6 +64057,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cavity of left ventricle) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Luminal space of the left ventricle of the heart.") +AnnotationAssertion( "EMAPA:26038") +AnnotationAssertion( "FMA:9466") AnnotationAssertion(rdfs:label "cavity of left ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40223,6 +64067,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cavity of right atrium) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Luminal space of the right atrium of the heart.") +AnnotationAssertion( "EMAPA:26020") +AnnotationAssertion( "FMA:11359") AnnotationAssertion(rdfs:label "cavity of right atrium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40230,6 +64077,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal ectoderm) +AnnotationAssertion(Annotation( "PMID:23020903") Annotation( "http://orcid.org/0000-0002-6601-2165") "The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches.") +AnnotationAssertion( "TAO:0001379") +AnnotationAssertion( "ZFA:0001379") AnnotationAssertion(rdfs:label "pharyngeal ectoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40239,6 +64089,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (central nervous system gray matter layer) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A layer of of the central nervous system that is part of gray matter.") +AnnotationAssertion( "FMA:83142") AnnotationAssertion(rdfs:label "central nervous system gray matter layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40250,16 +64102,55 @@ AnnotationAssertion(rdfs:label " SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (phlegm) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Mucus produced in the respiratory tract.") +AnnotationAssertion( "NCIT:C93171") +AnnotationAssertion( "UMLS:C0225378") +AnnotationAssertion(rdfs:label "phlegm") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (respiratory system mucus) + +AnnotationAssertion(Annotation( "Wikipedia:Nasal_mucus#Respiratory_system") Annotation( "http://orcid.org/0000-0002-6601-2165") "Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm).") +AnnotationAssertion(rdfs:label "respiratory system mucus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pit) + +AnnotationAssertion(Annotation( "AEO:0000204") Annotation( "AEO:JB") "An roughly circular indentation in a surface.") +AnnotationAssertion( "AEO:0000204") +AnnotationAssertion(rdfs:label "pit") +SubClassOf( ) + # Class: (lamina of gray matter of spinal cord) +AnnotationAssertion( "FMA:68861") +AnnotationAssertion( "Wikipedia:Rexed_laminae") +AnnotationAssertion( "http://neurolex.org/wiki/Category:Rexed_spinal_cord_parcellation_scheme_region") AnnotationAssertion(rdfs:label "lamina of gray matter of spinal cord") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (dorsal part of optic cup) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The dorsal region of the optic cup that gives rise to the dorsal part of the retina.") +AnnotationAssertion(rdfs:label "dorsal part of optic cup") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (future central nervous system) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Primordium that develops into the central nervous system.") AnnotationAssertion(rdfs:label "future central nervous system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40269,14 +64160,38 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future nervous system) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Primordium that develops into the nervous system.") +AnnotationAssertion( "AAO:0000477") AnnotationAssertion(rdfs:label "future nervous system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelium of terminal part of digestive tract) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Epithelium lining the distalmost portion of the digestive tract.") +AnnotationAssertion( "BTO:0005445") +AnnotationAssertion( "WBbt:0005800") +AnnotationAssertion(rdfs:label "epithelium of terminal part of digestive tract") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (muscle tissue of terminal part of digestive tract) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any muscle tissue of the distalmost portion of the digestive tract.") +AnnotationAssertion(rdfs:label "muscle tissue of terminal part of digestive tract") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (entire extraembryonic component) +AnnotationAssertion(Annotation( "AEO:0000195") Annotation( "AEO:JB") "The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism.") +AnnotationAssertion( "AEO:0000195") +AnnotationAssertion( "EHDAA2:0000003") +AnnotationAssertion( "EMAPA:16042") AnnotationAssertion(rdfs:label "entire extraembryonic component") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -40285,11 +64200,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (transitional anatomical structure) +AnnotationAssertion(Annotation( "AEO:0000132") Annotation( "AEO:JB") "An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development.") +AnnotationAssertion( "AEO:0000132") AnnotationAssertion(rdfs:label "transitional anatomical structure") SubClassOf( ) # Class: (developing mesenchymal structure) +AnnotationAssertion(Annotation( "AEO:0001016") Annotation( "AEO:JB") "A mesenchyme-derived anatomical entity undergoing a transtion to become another structure.") +AnnotationAssertion( "AEO:0001016") AnnotationAssertion(rdfs:label "developing mesenchymal structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40297,27 +64216,84 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdominal viscera) +AnnotationAssertion(Annotation( "OBOL:automatic") "A viscus that is part of a abdomen.") +AnnotationAssertion( "FMA:32413") +AnnotationAssertion( "FMA:67355") AnnotationAssertion(rdfs:label "abdominal viscera") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (muscle layer of rectum) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A muscle layer that is part of the rectum.") +AnnotationAssertion( "FMA:15035") +AnnotationAssertion(rdfs:label "muscle layer of rectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (rectum smooth muscle tissue) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any portion of smooth muscle tissue that is part of the rectum.") +AnnotationAssertion(rdfs:label "rectum smooth muscle tissue") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (fibrocollagenous connective tissue) +AnnotationAssertion( "FMA:83521") AnnotationAssertion(rdfs:label "fibrocollagenous connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (caudal vertebra endochondral element) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx).") +AnnotationAssertion(rdfs:label "caudal vertebra endochondral element") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +EquivalentClasses( ObjectUnionOf( )) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (skin of lower lip) +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a lower lip.") +AnnotationAssertion( "FMA:24767") +AnnotationAssertion( "SCTID:281630002") AnnotationAssertion(rdfs:label "skin of lower lip") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (skin of upper lip) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a upper lip.") +AnnotationAssertion( "FMA:24765") +AnnotationAssertion( "SCTID:281629007") +AnnotationAssertion(rdfs:label "skin of upper lip") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (stroma of pancreas) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A stroma that is part of a pancreas.") +AnnotationAssertion( "FMA:63121") +AnnotationAssertion(rdfs:label "stroma of pancreas") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (rhombomere boundary) +AnnotationAssertion(Annotation( "GO:0021654") "A boundary delimiting a rhombomere.") AnnotationAssertion(rdfs:label "rhombomere boundary") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40327,7 +64303,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skeletal musculature) -AnnotationAssertion( ) +AnnotationAssertion( "EHDAA2:0001842") +AnnotationAssertion( "EMAPA:35578") AnnotationAssertion(rdfs:label "skeletal musculature") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -40335,6 +64312,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (submucosa of digestive tract) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any portion of submucosa that lines the digestive tract.") AnnotationAssertion(rdfs:label "submucosa of digestive tract") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40342,13 +64320,51 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (layer of muscle tissue) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any organ component layer that consists of muscle tissue.") +AnnotationAssertion( "FMA:45634") +AnnotationAssertion( "NCIT:C75444") +AnnotationAssertion( "UMLS:C0225358") AnnotationAssertion(rdfs:label "layer of muscle tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (muscular coat of digestive tract) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A muscular coat that is part of a digestive tract.") +AnnotationAssertion(rdfs:label "muscular coat of digestive tract") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (ethmoid foramen) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An bone foramen in the ethmoid bone.") +AnnotationAssertion( "Wikipedia:Ethmoidal_foramina") +AnnotationAssertion(rdfs:comment "Taxon nodes: In humans, refers to anterior or posterior ethmoid foramina") +AnnotationAssertion(rdfs:label "ethmoid foramen") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (lumen of intestine) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The anatomical space within the intestine.") +AnnotationAssertion( "FMA:14586") +AnnotationAssertion( "TADS:0000495") +AnnotationAssertion( "WBbt:0005791") +AnnotationAssertion( "ZFA:0005807") +AnnotationAssertion(rdfs:label "lumen of intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (trigeminal nerve muscle) +AnnotationAssertion(Annotation( "MFMO:0000072") "Muscle innervated by the trigeminal nerve (Cranial Nerve V).") +AnnotationAssertion( "MFMO:0000072") AnnotationAssertion(rdfs:label "trigeminal nerve muscle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40357,6 +64373,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac muscle tissue of ventricle) +AnnotationAssertion( "FMA:83450") AnnotationAssertion(rdfs:label "cardiac muscle tissue of ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40364,14 +64381,37 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (heart vasculature) +AnnotationAssertion(Annotation( "ZFA:0005811") Annotation( "ZFA:CVS") "An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart.") +AnnotationAssertion( "FMA:73747") +AnnotationAssertion( "ZFA:0005811") AnnotationAssertion(rdfs:label "heart vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (dorsal side of post-anal tail) + +AnnotationAssertion(rdfs:label "dorsal side of post-anal tail") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (bladder organ) + +AnnotationAssertion(Annotation( "BTO:0000123") "A membranous sac in animals that serves as the receptacle of a liquid or contains gas.") +AnnotationAssertion( "BTO:0000123") +AnnotationAssertion(rdfs:label "bladder organ") +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (reproductive system mucosa) +AnnotationAssertion( "BTO:0002439") AnnotationAssertion(rdfs:label "reproductive system mucosa") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40379,6 +64419,8 @@ SubClassOf( (intramuscular adipose tissue) +AnnotationAssertion(Annotation( "BTO:0004043") "Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes.") +AnnotationAssertion( "BTO:0004043") AnnotationAssertion(rdfs:label "intramuscular adipose tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40386,13 +64428,29 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (carotid artery endothelium) +AnnotationAssertion( "BTO:0004626") AnnotationAssertion(rdfs:label "carotid artery endothelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (mucous gland of lung) + +AnnotationAssertion( "BTO:0004638") +AnnotationAssertion( "FMA:13119") +AnnotationAssertion( "SCTID:88410004") +AnnotationAssertion(rdfs:label "mucous gland of lung") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (skin epithelium) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any region of epithelium that is part of a skin region.") +AnnotationAssertion( "BTO:0004382") AnnotationAssertion(rdfs:label "skin epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40400,6 +64458,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (chorioretinal region) +AnnotationAssertion(Annotation( "UBERON:drseb") Annotation( "http://orcid.org/0000-0002-6601-2165") "The part of the eye that consists of both the retina and the optic choroid.") +AnnotationAssertion( "SCTID:110701000") AnnotationAssertion(rdfs:label "chorioretinal region") SubClassOf( ) SubClassOf( ) @@ -40410,7 +64470,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gray matter of hindbrain) -AnnotationAssertion( ) +AnnotationAssertion( "DHBA:10654") +AnnotationAssertion( "FMA:268630") AnnotationAssertion(rdfs:label "gray matter of hindbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40418,7 +64479,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gray matter of midbrain) -AnnotationAssertion( ) +AnnotationAssertion( "DHBA:10649") +AnnotationAssertion( "FMA:83913") AnnotationAssertion(rdfs:label "gray matter of midbrain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40426,6 +64488,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sensory organ epithelium) +AnnotationAssertion( "EMAPA:35952") +AnnotationAssertion( "MA:0003174") AnnotationAssertion(rdfs:label "sensory organ epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40433,6 +64497,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (exocrine gland of integumental system) +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "http://orcid.org/0000-0002-6601-2165") "An exocrine gland that is part of a integumental system.") AnnotationAssertion(rdfs:label "exocrine gland of integumental system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40440,13 +64505,25 @@ SubClassOf( (surface of eyeball) +AnnotationAssertion( "FMA:58315") AnnotationAssertion(rdfs:label "surface of eyeball") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (splenic arteriole) + +AnnotationAssertion( "NCIT:C33596") +AnnotationAssertion( "SCTID:282511007") +AnnotationAssertion(rdfs:label "splenic arteriole") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (reproductive gland secretion) +AnnotationAssertion(Annotation( "UBERON:cjm") "A portion of organism substance that is secreted by a reproductive gland.") AnnotationAssertion(rdfs:label "reproductive gland secretion") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40454,6 +64531,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nervous system cell part layer) +AnnotationAssertion(Annotation( "NLX:149357") "Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO].") +AnnotationAssertion( "NLX:149357") AnnotationAssertion(rdfs:label "nervous system cell part layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40462,6 +64541,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (visceral serous membrane) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Serous membrane layer that is adjacent to and lines an organ.") +AnnotationAssertion( "FMA:15860") AnnotationAssertion(rdfs:label "visceral serous membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40471,6 +64552,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (parietal serous membrane) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Serous membrane layer that lines to a body cavity.") +AnnotationAssertion( "FMA:15859") +AnnotationAssertion( "MA:0002448") AnnotationAssertion(rdfs:label "parietal serous membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40480,6 +64564,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lung field) +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_lung") "A specific region of the foregut into the area in which the lung will develop.") +AnnotationAssertion( "SCTID:34922002") AnnotationAssertion(rdfs:label "lung field") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40489,23 +64575,34 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (developing neuroepithelium) +AnnotationAssertion(Annotation( "AEO:0001008") Annotation( "AEO:JB") "An embryonic or larval epithelium that is committed to form part of the nervous system.") +AnnotationAssertion( "AEO:0001008") +AnnotationAssertion( "BTO:0000314") +AnnotationAssertion( "EHDAA2_RETIRED:0004654") +AnnotationAssertion( "FMA:64807") AnnotationAssertion(rdfs:label "developing neuroepithelium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (proliferating neuroepithelium) +AnnotationAssertion(Annotation( "AEO:0001009") "An epithelium that is undergoing proliferation to provide large numbers of neuronal cells.") +AnnotationAssertion( "AEO:0001009") AnnotationAssertion(rdfs:label "proliferating neuroepithelium") SubClassOf( ) # Class: (differentiating neuroepithelium) +AnnotationAssertion(Annotation( "AEO:0001010") "A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells.") +AnnotationAssertion( "AEO:0001010") AnnotationAssertion(rdfs:label "differentiating neuroepithelium") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (hindbrain marginal layer) +AnnotationAssertion( "DHBA:12694") +AnnotationAssertion( "EMAPA:32916") AnnotationAssertion(rdfs:label "hindbrain marginal layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40514,6 +64611,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (spinal cord ventricular layer) +AnnotationAssertion( "EHDAA2:0001267") +AnnotationAssertion( "EMAPA:17585") AnnotationAssertion(rdfs:label "spinal cord ventricular layer") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40522,7 +64621,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cranial neuron projection bundle) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ISBN:0471888893") Annotation( "http://orcid.org/0000-0002-6601-2165") "Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain.") AnnotationAssertion(rdfs:label "cranial neuron projection bundle") SubClassOf( ) SubClassOf( ) @@ -40532,7 +64631,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (autonomic nerve) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "Wikipedia:Autonomic_nerve") "The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa.") +AnnotationAssertion( "FMA:5866") +AnnotationAssertion( "MESH:D017776") +AnnotationAssertion( "SCTID:276145003") +AnnotationAssertion( "Wikipedia:Autonomic_nerve") AnnotationAssertion(rdfs:label "autonomic nerve") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -40541,7 +64644,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (sympathetic nerve) -AnnotationAssertion( ) +AnnotationAssertion( "SCTID:181098007") AnnotationAssertion(rdfs:label "sympathetic nerve") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40550,11 +64653,15 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lymphomyeloid tissue) +AnnotationAssertion( "FMA:79770") +AnnotationAssertion( "NCIT:C41168") AnnotationAssertion(rdfs:label "lymphomyeloid tissue") SubClassOf( ) # Class: (bodily gas) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any substance in the body or expelled from the body that is in a gaseous state.") +AnnotationAssertion( "FMA:84580") AnnotationAssertion(rdfs:label "bodily gas") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40562,6 +64669,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (air in respiratory system) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any portion of gas located in a part of the respiratory system that is composed primarily of air.") +AnnotationAssertion( "FMA:84581") AnnotationAssertion(rdfs:label "air in respiratory system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40569,6 +64678,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (prechordal mesoderm) +AnnotationAssertion(Annotation( "MGI:anna") "The area of axial mesoderm that develops into the prechordal plate.") AnnotationAssertion(rdfs:label "prechordal mesoderm") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40577,6 +64687,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left atrium endocardium) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Endocardium that is part of the left atrium.") +AnnotationAssertion( "FMA:7286") +AnnotationAssertion( "SCTID:190064008") +AnnotationAssertion( "VHOG:0001226") AnnotationAssertion(rdfs:label "left atrium endocardium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40591,27 +64705,25 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (multi organ part structure) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0020001") "An multicellular anatomical structure that has subparts of multiple organs as a part.") +AnnotationAssertion( "CARO:0020001") AnnotationAssertion(rdfs:label "multi organ part structure") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cell cluster) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0020002") "A cluster of cells, largely surrounded by a morphological boundary.") +AnnotationAssertion( "CARO:0020002") +AnnotationAssertion( "FMA:62807") AnnotationAssertion(rdfs:label "cell cluster") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (disconnected anatomical group) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "CARO:0020000") "Material anatomical entity consisting of multiple anatomical structures that are not connected to each other.") +AnnotationAssertion( "CARO:0020000") AnnotationAssertion(rdfs:label "disconnected anatomical group") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -40620,15 +64732,14 @@ SubClassOf( ObjectMinCardinality( # Class: (anatomical collection) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A collection of anatomical structures that are alike in terms of their morphology or developmental origin.") AnnotationAssertion(rdfs:label "anatomical collection") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (external soft tissue zone) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures.") AnnotationAssertion(rdfs:label "external soft tissue zone") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -40637,8 +64748,18 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (epithelium of biliary system) + +AnnotationAssertion(Annotation( "BTO:0001513") Annotation( "MGI:cs") Annotation( "http://orcid.org/0000-0002-6601-2165") "The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts.") +AnnotationAssertion( "BTO:0001513") +AnnotationAssertion(rdfs:label "epithelium of biliary system") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (layer of smooth muscle tissue) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any organ component layer that consists of smooth muscle tissue.") AnnotationAssertion(rdfs:label "layer of smooth muscle tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40646,11 +64767,31 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (zone of organ) +AnnotationAssertion( "FMA:55268") AnnotationAssertion(rdfs:label "zone of organ") SubClassOf( ) +# Class: (excreted gas) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any gaseous product of an excretory process.") +AnnotationAssertion(rdfs:label "excreted gas") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + +# Class: (gas excreted from digestive tract) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any excreted gas that is produced by the digestive tract.") +AnnotationAssertion( "FMA:78440") +AnnotationAssertion(rdfs:comment "In mammals, mostly produced as a byproduct of bacterial fermentation in the gastrointestinal (GI) tract, especially the colon, and excreted through the rectum") +AnnotationAssertion(rdfs:label "gas excreted from digestive tract") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (gas in respiratory system) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any portion of gas located in a part of the respiratory system.") AnnotationAssertion(rdfs:label "gas in respiratory system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40658,6 +64799,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelial layer of duct) +AnnotationAssertion( "NCIT:C25787") +AnnotationAssertion( "UMLS:C1512086") AnnotationAssertion(rdfs:label "epithelial layer of duct") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40665,6 +64808,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (jaw mesenchyme) +AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a developing jaw [Automatically generated definition].") +AnnotationAssertion( "EMAPA:32907") +AnnotationAssertion( "EMAPA:35454") AnnotationAssertion(rdfs:label "jaw mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40672,11 +64818,21 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (jaw epithelium) +AnnotationAssertion( "EMAPA:32904") +AnnotationAssertion( "MA:0003220") AnnotationAssertion(rdfs:label "jaw epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (rectal artery) + +AnnotationAssertion( "SCTID:277967008") +AnnotationAssertion(rdfs:label "rectal artery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (excretory duct) AnnotationAssertion(rdfs:label "excretory duct") @@ -40684,6 +64840,7 @@ SubClassOf( (material entity in digestive tract) +AnnotationAssertion(Annotation( "https://github.com/EnvironmentOntology/envo/issues/110") "Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included.") AnnotationAssertion(rdfs:label "material entity in digestive tract") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40691,6 +64848,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (entire surface of organism) +AnnotationAssertion(Annotation( "FMA:61695") "Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface.") +AnnotationAssertion( "FMA:61695") +AnnotationAssertion( "NCIT:C29667") +AnnotationAssertion( "SCTID:261060002") +AnnotationAssertion( "UMLS:C0489451") AnnotationAssertion(rdfs:label "entire surface of organism") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40698,6 +64860,10 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (branch of external carotid artery) +AnnotationAssertion( "FMA:70505") +AnnotationAssertion( "NCIT:C32552") +AnnotationAssertion( "SCTID:244216003") +AnnotationAssertion( "UMLS:C0447038") AnnotationAssertion(rdfs:label "branch of external carotid artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40705,7 +64871,11 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (esophageal artery) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "ncithesaurus:Esophageal_Artery") "Any of several arteries that arise from the aorta and supply blood to the esophagus.") +AnnotationAssertion( "FMA:4149") +AnnotationAssertion( "NCIT:C32535") +AnnotationAssertion( "SCTID:56548006") +AnnotationAssertion( "UMLS:C0226294") AnnotationAssertion(rdfs:label "esophageal artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40716,14 +64886,25 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (uveal vein) +AnnotationAssertion( "FMA:51797") +AnnotationAssertion( "SCTID:149683007") AnnotationAssertion(rdfs:label "uveal vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (colic artery) + +AnnotationAssertion( "SCTID:77852007") +AnnotationAssertion(rdfs:label "colic artery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vasculature of integument) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin.") +AnnotationAssertion( "FMA:225275") AnnotationAssertion(rdfs:label "vasculature of integument") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40732,6 +64913,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (superficial vein) +AnnotationAssertion(Annotation( "ncithesaurus:Superficial_Vein") "Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers.") +AnnotationAssertion( "FMA:76719") +AnnotationAssertion( "NCIT:C33666") +AnnotationAssertion( "SCTID:341382008") +AnnotationAssertion( "UMLS:C0226513") +AnnotationAssertion( "Wikipedia:Superficial_vein") AnnotationAssertion(rdfs:label "superficial vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40739,6 +64926,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (deep vasculature) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin.") AnnotationAssertion(rdfs:label "deep vasculature") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40746,6 +64934,12 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (deep vein) +AnnotationAssertion(Annotation( "ncithesaurus:Deep_Vein") "A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery.") +AnnotationAssertion( "FMA:76718") +AnnotationAssertion( "NCIT:C32444") +AnnotationAssertion( "SCTID:341484008") +AnnotationAssertion( "UMLS:C0226514") +AnnotationAssertion( "Wikipedia:Deep_vein") AnnotationAssertion(rdfs:label "deep vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40753,6 +64947,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left cardiac chamber) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any chamber of the left side of the heart.") +AnnotationAssertion( "FMA:7166") +AnnotationAssertion( "SCTID:362008007") AnnotationAssertion(rdfs:label "left cardiac chamber") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40761,6 +64958,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right cardiac chamber) +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any chamber of the right side of the heart.") +AnnotationAssertion( "FMA:7165") +AnnotationAssertion( "SCTID:362007002") AnnotationAssertion(rdfs:label "right cardiac chamber") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40769,12 +64969,20 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ocular adnexa) +AnnotationAssertion(Annotation( "HPO:pr") Annotation( "UBERON:cjm") Annotation( "http://medical-dictionary.thefreedictionary.com/ocular+adnexa") Annotation( "https://github.com/obophenotype/uberon/issues/1132") "The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.") +AnnotationAssertion( "FMA:76554") +AnnotationAssertion( "NCIT:C32574") +AnnotationAssertion( "SCTID:120612006") +AnnotationAssertion( "UMLS:C0229243") +AnnotationAssertion( "Wikipedia:Accessory_visual_structures") AnnotationAssertion(rdfs:label "ocular adnexa") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (cavity of cardiac chamber) +AnnotationAssertion( "EHDAA2:0004181") +AnnotationAssertion( "FMA:9464") AnnotationAssertion(rdfs:label "cavity of cardiac chamber") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40783,6 +64991,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (intrapulmonary bronchus) +AnnotationAssertion( "FMA:223208") +AnnotationAssertion( "NCIT:C12930") +AnnotationAssertion( "UMLS:C1512970") AnnotationAssertion(rdfs:label "intrapulmonary bronchus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40790,14 +65001,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future mouth) +AnnotationAssertion(Annotation( "MP:0003119") "The primordial mouth region of the developing head.") +AnnotationAssertion( "FMA:293105") AnnotationAssertion(rdfs:label "future mouth") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (muscle layer of sigmoid colon) + +AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/issues/1162") "A muscle layer that is part of the sigmoid colon.") +AnnotationAssertion( "FMA:15028") +AnnotationAssertion(rdfs:label "muscle layer of sigmoid colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (serous cavity) +AnnotationAssertion( "FMA:12241") +AnnotationAssertion( "SCTID:304404008") AnnotationAssertion(rdfs:label "serous cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40805,6 +65029,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pericardial fat) +AnnotationAssertion(Annotation( "DOI:10.5935/abc.20130138") "The sum of epicardial and paracardial fat deposits.") +AnnotationAssertion( "SCTID:42267001") +AnnotationAssertion( "ZFA:0005765") AnnotationAssertion(rdfs:label "pericardial fat") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40812,6 +65039,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (paracardial fat) +AnnotationAssertion(Annotation( "DOI:10.5935/abc.20130138") "Fat deposits in the mediastinum outside the parietal pericardium .") AnnotationAssertion(rdfs:label "paracardial fat") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40819,6 +65047,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (visceral fat) +AnnotationAssertion(Annotation( "UBERON:cjm") "Any fat deposit surrounding a visceral organ.") AnnotationAssertion(rdfs:label "visceral fat") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40826,6 +65055,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (abdominopelvic cavity) +AnnotationAssertion(Annotation( "UBERON:cjm") "The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity.") +AnnotationAssertion( "FMA:12267") +AnnotationAssertion( "Wikipedia:Abdominopelvic_cavity") AnnotationAssertion(rdfs:label "abdominopelvic cavity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40834,6 +65066,9 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (peritoneal sac) +AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/issues/86") "A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity.") +AnnotationAssertion( "EMAPA:16137") +AnnotationAssertion( "FMA:9908") AnnotationAssertion(rdfs:label "peritoneal sac") SubClassOf( ) SubClassOf( ) @@ -40843,6 +65078,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (wall of blood vessel) +AnnotationAssertion( "BTO:0004378") +AnnotationAssertion( "FMA:67473") AnnotationAssertion(rdfs:label "wall of blood vessel") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40852,6 +65089,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory primordium epithelium) +AnnotationAssertion( "EHDAA2:0004070") AnnotationAssertion(rdfs:label "respiratory primordium epithelium") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40864,6 +65102,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory primordium mesenchyme) +AnnotationAssertion( "EHDAA2:0004071") AnnotationAssertion(rdfs:label "respiratory primordium mesenchyme") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40873,6 +65112,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiopharyngeal field) +AnnotationAssertion(Annotation( "http://www.nature.com/nature/journal/v520/n7548/full/nature14435.html#bx1") Annotation( "https://orcid.org/0000-0003-3308-6245") "An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles.") AnnotationAssertion(rdfs:label "cardiopharyngeal field") SubClassOf( ) SubClassOf( ) @@ -40881,22 +65121,36 @@ SubClassOf( (fibroelastic connective tissue) +AnnotationAssertion( "FMA:83520") AnnotationAssertion(rdfs:label "fibroelastic connective tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +# Class: (rectosigmoid junction) + +AnnotationAssertion(Annotation( "NCIT:C54188") Annotation( "https://github.com/obophenotype/uberon/issues/1319") Annotation( "https://www.cdc.gov/cancer/npcr/pdf/abstracting/colon.pdf") "An anatomical junction that is between the sigmoid colon and rectum.") +AnnotationAssertion( "NCIT:C54188") +AnnotationAssertion( "SCTID:245429006") +AnnotationAssertion(rdfs:label "rectosigmoid junction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (anatomical surface region) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/issues/1324") "Material anatomical entity that forms the outermost boundary of an anatomical structure.") +AnnotationAssertion( "AAO:0010270") +AnnotationAssertion( "ZFA:0005594") AnnotationAssertion(rdfs:label "anatomical surface region") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (coelomic fluid) +AnnotationAssertion(Annotation( "PMID:10874572") Annotation( "https://github.com/obophenotype/uberon/issues/1326") "A bodily fluid that is located in the coelom.") +AnnotationAssertion( "BTO:0001708") AnnotationAssertion(rdfs:label "coelomic fluid") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40904,6 +65158,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (respiratory system gland) +AnnotationAssertion(Annotation( "UBERON:cjm") "Any gland that is part os the respiratory system.") AnnotationAssertion(rdfs:label "respiratory system gland") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40911,11 +65166,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (post-embryonic notochord) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "UBERON:cjm") "A notochord that has persisted beyond the embryonic stage.") AnnotationAssertion(rdfs:label "post-embryonic notochord") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40923,6 +65174,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (secretion of serous membrane) +AnnotationAssertion(Annotation( "FMA:20932") "A transudate found in the serous sac.") +AnnotationAssertion( "FMA:20932") AnnotationAssertion(rdfs:label "secretion of serous membrane") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40931,6 +65184,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (orifice of skull) +AnnotationAssertion( "FMA:53133") AnnotationAssertion(rdfs:label "orifice of skull") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40938,12 +65192,18 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (zygomaticotemporal nerve) +AnnotationAssertion(Annotation( "Wikipedia:Zygomaticotemporal_nerve") "The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit.") +AnnotationAssertion( "FMA:52972") +AnnotationAssertion( "SCTID:280243001") +AnnotationAssertion( "Wikipedia:Zygomaticotemporal_nerve") AnnotationAssertion(rdfs:label "zygomaticotemporal nerve") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (wall of left ventricle) +AnnotationAssertion(Annotation( "FMA:9556") "Wall of ventricle which is continuous with the wall of aorta.") +AnnotationAssertion( "FMA:9556") AnnotationAssertion(rdfs:label "wall of left ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40951,6 +65211,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (wall of right ventricle) +AnnotationAssertion(Annotation( "FMA:9533") "Wall of ventricle which is continuous with the wall of pulmonary trunk.") +AnnotationAssertion( "FMA:9533") AnnotationAssertion(rdfs:label "wall of right ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40958,6 +65220,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anterior wall of left ventricle) +AnnotationAssertion( "FMA:9560") AnnotationAssertion(rdfs:label "anterior wall of left ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40966,6 +65229,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anterior wall of right ventricle) +AnnotationAssertion(Annotation( "FMA:9553") "Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle.") +AnnotationAssertion( "FMA:9553") AnnotationAssertion(rdfs:label "anterior wall of right ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40973,6 +65238,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (myocardium of anterior wall of left ventricle) +AnnotationAssertion( "FMA:87177") AnnotationAssertion(rdfs:label "myocardium of anterior wall of left ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40980,6 +65246,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (myocardium of anterior wall of right ventricle) +AnnotationAssertion( "FMA:260877") AnnotationAssertion(rdfs:label "myocardium of anterior wall of right ventricle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -40987,11 +65254,23 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mucosa of lip) +AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a lip region [Automatically generated definition].") +AnnotationAssertion( "NCIT:C12226") AnnotationAssertion(rdfs:label "mucosa of lip") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (vasculature of spleen) + +AnnotationAssertion( "FMA:225251") +AnnotationAssertion( "SCTID:297287005") +AnnotationAssertion(rdfs:label "vasculature of spleen") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vasculature of central nervous system plus retina) AnnotationAssertion(rdfs:label "vasculature of central nervous system plus retina") @@ -41000,13 +65279,24 @@ SubClassOf( (vasculature of central nervous system) +AnnotationAssertion( "FMA:259905") AnnotationAssertion(rdfs:label "vasculature of central nervous system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (wall of gallbladder) + +AnnotationAssertion( "FMA:14657") +AnnotationAssertion(rdfs:label "wall of gallbladder") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (wall of brachiocephalic artery) +AnnotationAssertion( "FMA:15089") AnnotationAssertion(rdfs:label "wall of brachiocephalic artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41014,13 +65304,24 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (wall of subclavian artery) +AnnotationAssertion( "FMA:15090") AnnotationAssertion(rdfs:label "wall of subclavian artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (wall of anal canal) + +AnnotationAssertion( "FMA:15704") +AnnotationAssertion(rdfs:label "wall of anal canal") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (wall of pulmonary artery) +AnnotationAssertion( "FMA:18211") AnnotationAssertion(rdfs:label "wall of pulmonary artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41028,6 +65329,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (wall of synovial tendon sheath) +AnnotationAssertion( "FMA:231590") AnnotationAssertion(rdfs:label "wall of synovial tendon sheath") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41036,14 +65338,26 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (wall of eyeball) +AnnotationAssertion( "FMA:58098") AnnotationAssertion(rdfs:label "wall of eyeball") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (wall of orbit) + +AnnotationAssertion( "FMA:63144") +AnnotationAssertion(rdfs:label "wall of orbit") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (wall of common carotid artery) +AnnotationAssertion( "FMA:66284") AnnotationAssertion(rdfs:label "wall of common carotid artery") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41051,6 +65365,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (wall of heart) +AnnotationAssertion(Annotation( "FMA:7274") "Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees.") +AnnotationAssertion( "FMA:7274") AnnotationAssertion(rdfs:label "wall of heart") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41059,8 +65375,39 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (cystic artery) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://en.wikipedia.org/wiki/Cystic_artery") "An artery that supplies oxygenated blood to the cystic duct.") +AnnotationAssertion( "FMA:14835") +AnnotationAssertion(rdfs:label "cystic artery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (sigmoid vein) + +AnnotationAssertion( "FMA:15395") +AnnotationAssertion(rdfs:label "sigmoid vein") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (pancreatic artery) + +AnnotationAssertion( "FMA:70471") +AnnotationAssertion(rdfs:label "pancreatic artery") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (right ovarian vein) +AnnotationAssertion(Annotation( "FMA:14342") "Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament.") +AnnotationAssertion( "FMA:14342") AnnotationAssertion(rdfs:label "right ovarian vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41069,6 +65416,8 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left ovarian vein) +AnnotationAssertion(Annotation( "FMA:14347") "Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament.") +AnnotationAssertion( "FMA:14347") AnnotationAssertion(rdfs:label "left ovarian vein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41076,20 +65425,44 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin of face) +AnnotationAssertion(Annotation( "UBERON:EJS") Annotation( "https://github.com/obophenotype/uberon/issues/34") "A zone of skin that is part of the face.") +AnnotationAssertion( "EMAPA:36657") +AnnotationAssertion( "FMA:24758") +AnnotationAssertion( "NCIT:C33561") +AnnotationAssertion( "SCTID:361703006") AnnotationAssertion(rdfs:label "skin of face") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (parenchyma of spleen) + +AnnotationAssertion(Annotation( "OBOL:automatic") "A parenchyma that is part of a spleen.") +AnnotationAssertion( "FMA:16029") +AnnotationAssertion(rdfs:label "parenchyma of spleen") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (digestive tract junction) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-7073-9172") "An anatomical junction between two parts of the digestive tract.") AnnotationAssertion(rdfs:label "digestive tract junction") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (axial vasculature) + +AnnotationAssertion( "ZFA:0001073") +AnnotationAssertion(rdfs:label "axial vasculature") +SubClassOf( ) + # Class: (postcranial axial cartilage) +AnnotationAssertion(Annotation( "ZFIN:curator") "Cartilage which is part of the axial skeleton.") +AnnotationAssertion( "ZFA:0001457") AnnotationAssertion(rdfs:label "postcranial axial cartilage") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41097,17 +65470,27 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (fenestrated capillary) +AnnotationAssertion(Annotation( "Wikipedia:Capillary#Types") Annotation( "Wikipedia:Fenestra_(histology)") "Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse.") +AnnotationAssertion( "FMA:63196") +AnnotationAssertion( "NCIT:C32595") +AnnotationAssertion( "TAO:0005260") +AnnotationAssertion( "Wikipedia:Capillary#Types") +AnnotationAssertion( "ZFA:0005260") AnnotationAssertion(rdfs:label "fenestrated capillary") SubClassOf( ) SubClassOf( ) # Class: (preplacodal ectoderm) +AnnotationAssertion(Annotation( "ZFIN:curator") "Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes.") +AnnotationAssertion( "ZFA:0007013") AnnotationAssertion(rdfs:label "preplacodal ectoderm") SubClassOf( ) # Class: (external integument structure) +AnnotationAssertion(Annotation( "AAO:EJS") "Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument.") +AnnotationAssertion(rdfs:comment "Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305") AnnotationAssertion(rdfs:label "external integument structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41115,6 +65498,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (head external integument structure) +AnnotationAssertion(Annotation( "AAO:EJS") "Dermal, epidermal, glandular and pigment structures of the external head integument.") AnnotationAssertion(rdfs:label "head external integument structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41122,13 +65506,23 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (body external integument structure) +AnnotationAssertion(Annotation( "AAO:EJS") "Dermal, epidermal, glandular and pigment structures of the body integument.") AnnotationAssertion(rdfs:label "body external integument structure") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (tail external integument structure) + +AnnotationAssertion(Annotation( "AAO:EJS") "Dermal, epidermal, glandular and pigment structures of the tail integument.") +AnnotationAssertion(rdfs:label "tail external integument structure") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (vasculature of respiratory integument) +AnnotationAssertion(Annotation( "AAO:EJS") "Blood vessels in respiratory skin.") AnnotationAssertion(rdfs:label "vasculature of respiratory integument") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41136,6 +65530,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (surface of bone) +AnnotationAssertion(Annotation( "PHENOSCAPE") "An anatomical surface that is part of a bone.") AnnotationAssertion(rdfs:label "surface of bone") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41150,6 +65545,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (left side of back) +AnnotationAssertion(Annotation( "https://microbiomedb.org/") "Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.") AnnotationAssertion(rdfs:label "left side of back") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41158,6 +65554,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (right side of back) +AnnotationAssertion(Annotation( "https://microbiomedb.org/") "Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.") AnnotationAssertion(rdfs:label "right side of back") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41166,27 +65563,158 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (Purkinje fiber network) +AnnotationAssertion(Annotation( "PMID:26786210") "A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles.") AnnotationAssertion(rdfs:label "Purkinje fiber network") SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (liver serosa) + +AnnotationAssertion(Annotation( "https://medical-dictionary.thefreedictionary.com/serosa+of+liver") Annotation( "https://orcid.org/0000-0002-0449-2730") "Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact.") +AnnotationAssertion(rdfs:label "liver serosa") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (liver subserosa) + +AnnotationAssertion(Annotation( "FMA:15812") Annotation( "https://medical-dictionary.thefreedictionary.com/subserosa+of+liver") Annotation( "https://orcid.org/0000-0002-0449-2730") "Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson.") +AnnotationAssertion(rdfs:label "liver subserosa") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (small intestine venule) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0003-4183-8865") "Venule of villus of small intestine.") +AnnotationAssertion(rdfs:label "small intestine venule") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (small intestine arteriole) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-4183-8865") "Arteriole of villus of small intestine.") +AnnotationAssertion(rdfs:label "small intestine arteriole") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (venule of anorectum) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "A venule that is located in the anorectum.") +AnnotationAssertion(rdfs:label "venule of anorectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (arteriole of anorectum) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "An arteriole that is located in the anorectum.") +AnnotationAssertion(rdfs:label "arteriole of anorectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (arteriole of colon) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") Annotation( "http://orcid.org/0000-0003-4183-8865") "An arteriole located in the colon.") +AnnotationAssertion(rdfs:label "arteriole of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (intestinal junction) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-7073-9172") "An anatomical junction between two parts of the intestine.") +AnnotationAssertion(rdfs:label "intestinal junction") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (bronchus submucosal gland) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") Annotation( "http://orcid.org/0000-0003-4183-8865") "A submucosal gland located in a bronchus.") +AnnotationAssertion(rdfs:label "bronchus submucosal gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (venule of colon) + +AnnotationAssertion(Annotation( "https://orcid.org/0000-0003-3440-1876") Annotation( "https://orcid.org/0000-0003-4183-8865") "A venule located in the colon.") +AnnotationAssertion(rdfs:label "venule of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (anorectum) + +AnnotationAssertion(Annotation( "DOI:10.1007/978-3-319-26938-2_8") Annotation( "DOI:10.1148/rg.2015150037") Annotation( "PMID:29742860") Annotation( "http://orcid.org/0000-0002-6826-8770") Annotation( "http://orcid.org/0000-0003-3440-1876") "A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus.") +AnnotationAssertion(rdfs:label "anorectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (capillary of anorectum) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "A capillary that is part of the anorectum.") +AnnotationAssertion(rdfs:label "capillary of anorectum") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (capillary of colon) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "A capillary that is part of the colon.") +AnnotationAssertion(rdfs:label "capillary of colon") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (capillary of small intestine) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") "A capillary that is part of a small intestine.") +AnnotationAssertion(rdfs:label "capillary of small intestine") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (airway submucosal gland) + +AnnotationAssertion(Annotation( "http://orcid.org/0000-0003-3440-1876") Annotation( "http://orcid.org/0000-0003-4183-8865") "A submucosal gland found in a respiratory tract.") +AnnotationAssertion( "EFO:0010666") +AnnotationAssertion(rdfs:label "airway submucosal gland") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (blood microvessel) +AnnotationAssertion(Annotation( "Wikipedia:Microcirculation") Annotation( "http://orcid.org/0000-0002-7073-9172") "Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins.") AnnotationAssertion(rdfs:label "blood microvessel") SubClassOf( ) SubClassOf( ) # Class: (noradrenergic cell groups) +AnnotationAssertion(Annotation( "WikipediaVersioned:Noradrenergic_cell_groups&oldid=965992184") "Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin).") AnnotationAssertion(rdfs:label "noradrenergic cell groups") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (excretory system) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "GO:0007588") "An anatomical system that eliminates waste products that arise as a result of metabolic activity.") AnnotationAssertion(rdfs:label "excretory system") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41194,6 +65722,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (capillary of brain) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-0819-0473") "A capillary that is part of the brain.") AnnotationAssertion(rdfs:label "capillary of brain") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41201,6 +65730,7 @@ SubClassOf( (thoracic aorta smooth muscle tissue) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-0819-0473") "A portion of smooth muscle tissue that is part of the thoracic aorta.") AnnotationAssertion(rdfs:label "thoracic aorta smooth muscle tissue") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41208,6 +65738,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin of clavicle region) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-0819-0473") "A zone of skin that is above the clavicle zone in the pectoral girdle region.") AnnotationAssertion(rdfs:label "skin of clavicle region") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41215,6 +65746,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin of external genitalia) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-0819-0473") "A zone of skin that is part of the external genitalia.") AnnotationAssertion(rdfs:label "skin of external genitalia") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41223,6 +65755,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin of gonad) +AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-0819-0473") "A zone of skin part of some gonad.") AnnotationAssertion(rdfs:label "skin of gonad") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41231,19 +65764,31 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (visceral muscle tissue) +AnnotationAssertion(Annotation( "BTO:0002780") Annotation( "CLAO:0001295") "A muscle tissue that is associated with soft internal organs (viscera).") +AnnotationAssertion(Annotation( "FBbt:00005070") Annotation( "https://en.wikipedia.org/wiki/Smooth_muscle") Annotation(rdfs:comment "PMID:8720463") rdfs:comment "It is quite common to refer to visceral muscles as smooth muscles, by analogy with vertebrates; however, most visceral muscles in arthropods are actually striated.") AnnotationAssertion(rdfs:label "visceral muscle tissue") SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) # Class: (visceral striated muscle tissue) +AnnotationAssertion(Annotation( "PMID:8720463") Annotation( "https://pressbooks.pub/rbtallitsch/chapter/chapter-6-muscle-tissue/") "A striated muscle tissue that is associated with soft internal organs (viscera).") AnnotationAssertion(rdfs:label "visceral striated muscle tissue") SubClassOf( ) SubClassOf( ) +# Class: (submucosal gland acinus) + +AnnotationAssertion(Annotation( "PMID:17394068") Annotation( "PMID:17707699") Annotation( "PMID:25648514") Annotation( "PMID:30864819") "A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium.") +AnnotationAssertion(rdfs:label "submucosal gland acinus") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (bronchopulmonary segment) -AnnotationAssertion( ) +AnnotationAssertion(Annotation( "FMA:7312") Annotation( "PMID:18271171") Annotation( "PMID:33620799") Annotation( "doi:10.1016/j.mpaic.2008.09.022") "A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface.") +AnnotationAssertion(Annotation( "PMID:18271171") Annotation( "doi:10.1016/j.mpaic.2008.09.022") rdfs:comment "A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung.") AnnotationAssertion(rdfs:label "bronchopulmonary segment") SubClassOf( ) SubClassOf( ) @@ -41252,6 +65797,7 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pulmonary venule) +AnnotationAssertion(Annotation( "PMID:22283705") Annotation( "PMID:30247823") "A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa.") AnnotationAssertion(rdfs:label "pulmonary venule") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) @@ -41264,7 +65810,10 @@ SubClassOf( ObjectSomeValuesFrom( SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) +SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ) +SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ) +SubClassOf(Annotation( ) ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) @@ -41282,12 +65831,16 @@ SubClassOf(ObjectIntersectionOf( SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) +SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) +SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) +SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) +SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) SubClassOf(ObjectIntersectionOf( ObjectSomeValuesFrom( )) ObjectSomeValuesFrom( )) diff --git a/src/patterns/data/default/MarkersToCells.tsv b/src/patterns/data/default/MarkersToCells.tsv index f1899f5..2761f1f 100644 --- a/src/patterns/data/default/MarkersToCells.tsv +++ b/src/patterns/data/default/MarkersToCells.tsv @@ -1,7 +1,7 @@ defined_class Cell_type has_characterization_set Marker_set Organ Species_abbv Species FBeta_confidence_score Marker_set_xref -CL:4028006 alveolar adventitial fibroblast CL:4037001 SCARA5|CD248 Lung Human NCBITaxon:9606 0.85 -CL:4028004 alveolar type 1 fibroblast cell CL:4037002 AOC3|LUM Lung Human NCBITaxon:9606 0.7 -CL:0000583 alveolar macrophage CL:4037003 MSR1|FABP4 Lung Human NCBITaxon:9606 0.8 -CL:4033041 CCL3-positive alveolar macrophage CL:4037004 TNIP3|CXCL5 Lung Human NCBITaxon:9606 0.67 -CL:4033042 metallothionein-positive alveolar macrophage CL:4037005 HMOX1|HPGD Lung Human NCBITaxon:9606 0.41 -CL:0000000 cell CL:4037006 PCLAF|RRM2|UBE2C|NUSAP1 Lung Human NCBITaxon:9606 0.26 +CL:4028006 CL:4028006 CL:4037001 SCARA5|CD248 Lung Human NCBITaxon:9606 0.85 https://doi.org/10.5281/zenodo.11165918 +CL:4028004 CL:4028004 CL:4037002 AOC3|LUM Lung Human NCBITaxon:9606 0.7 https://doi.org/10.5281/zenodo.11165918 +CL:0000583 CL:0000583 CL:4037003 MSR1|FABP4 Lung Human NCBITaxon:9606 0.8 https://doi.org/10.5281/zenodo.11165918 +CL:4033041 CL:4033041 CL:4037004 TNIP3|CXCL5 Lung Human NCBITaxon:9606 0.67 https://doi.org/10.5281/zenodo.11165918 +CL:4033042 CL:4033042 CL:4037005 HMOX1|HPGD Lung Human NCBITaxon:9606 0.41 https://doi.org/10.5281/zenodo.11165918 +CL:0000000 CL:0000000 CL:4037006 PCLAF|RRM2|UBE2C|NUSAP1 Lung Human NCBITaxon:9606 0.26 https://doi.org/10.5281/zenodo.11165918 diff --git a/src/patterns/data/default/NSForestMarkers.tsv b/src/patterns/data/default/NSForestMarkers.tsv index 8cbdc8f..83c7035 100644 --- a/src/patterns/data/default/NSForestMarkers.tsv +++ b/src/patterns/data/default/NSForestMarkers.tsv @@ -1,7 +1,7 @@ defined_class Marker_set_of Minimal_markers Minimal_markers_label Organ Species_abbv Organ_region Parent FBeta_confidence_score -CL:4037001 alveolar adventitial fibroblast ncbigene:286133|ncbigene:57124 SCARA5|CD248 Lung Human UBERON:0002048 SO:0001260 0.85 -CL:4037002 alveolar type 1 fibroblast cell ncbigene:8639|ncbigene:4060 AOC3|LUM Lung Human UBERON:0002048 SO:0001260 0.7 -CL:4037003 alveolar macrophage ncbigene:4481|ncbigene:2168 MSR1|FABP4 Lung Human UBERON:0002048 SO:0001260 0.8 -CL:4037004 CCL3-positive alveolar macrophage ncbigene:79931|ncbigene:6374 TNIP3|CXCL5 Lung Human UBERON:0002048 SO:0001260 0.67 -CL:4037005 metallothionein-positive alveolar macrophage ncbigene:3162|ncbigene:3248 HMOX1|HPGD Lung Human UBERON:0002048 SO:0001260 0.41 -CL:4037006 cell ncbigene:9768|ncbigene:6241|ncbigene:11065|ncbigene:51203 PCLAF|RRM2|UBE2C|NUSAP1 Lung Human UBERON:0002048 SO:0001260 0.26 +CL:4037001 alveolar adventitial fibroblast ensembl:ENSG00000168079|ensembl:ENSG00000174807 SCARA5|CD248 Lung Human UBERON:0002048 SO:0001260 0.85 +CL:4037002 alveolar type 1 fibroblast cell ensembl:ENSG00000131471|ensembl:ENSG00000139329 AOC3|LUM Lung Human UBERON:0002048 SO:0001260 0.7 +CL:4037003 alveolar macrophage ensembl:ENSG00000038945|ensembl:ENSG00000170323 MSR1|FABP4 Lung Human UBERON:0002048 SO:0001260 0.8 +CL:4037004 CCL3-positive alveolar macrophage ensembl:ENSG00000050730|ensembl:ENSG00000163735 TNIP3|CXCL5 Lung Human UBERON:0002048 SO:0001260 0.67 +CL:4037005 metallothionein-positive alveolar macrophage ensembl:ENSG00000100292|ensembl:ENSG00000164120 HMOX1|HPGD Lung Human UBERON:0002048 SO:0001260 0.41 +CL:4037006 cell ensembl:ENSG00000166803|ensembl:ENSG00000171848|ensembl:ENSG00000175063|ensembl:ENSG00000137804 PCLAF|RRM2|UBE2C|NUSAP1 Lung Human UBERON:0002048 SO:0001260 0.26 diff --git a/src/patterns/definitions.owl b/src/patterns/definitions.owl index 26a081c..ee351d5 100644 --- a/src/patterns/definitions.owl +++ b/src/patterns/definitions.owl @@ -7,23 +7,29 @@ Prefix(rdfs:=) Ontology( - -Annotation(owl:versionInfo "2024-07-26") - -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) + +Annotation(owl:versionInfo "2024-07-29") + +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -32,7 +38,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(ObjectProperty()) +Declaration(ObjectProperty()) Declaration(AnnotationProperty()) +Declaration(AnnotationProperty()) @@ -40,47 +48,77 @@ Declaration(AnnotationProperty()) # Classes ############################ +# Class: () + +AnnotationAssertion(Annotation( "https://doi.org/10.5281/zenodo.11165918") rdfs:comment "A cell in the Human Lung has the gene markers PCLAF, RRM2, UBE2C, NUSAP1 with a NS-Forest FBeta value of 0.26.") +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: () + +AnnotationAssertion(Annotation( "https://doi.org/10.5281/zenodo.11165918") rdfs:comment "A alveolar macrophage in the Human Lung has the gene markers MSR1, FABP4 with a NS-Forest FBeta value of 0.8.") +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: () + +AnnotationAssertion(Annotation( "https://doi.org/10.5281/zenodo.11165918") rdfs:comment "A alveolar type 1 fibroblast cell in the Human Lung has the gene markers AOC3, LUM with a NS-Forest FBeta value of 0.7.") +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: () + +AnnotationAssertion(Annotation( "https://doi.org/10.5281/zenodo.11165918") rdfs:comment "A alveolar adventitial fibroblast in the Human Lung has the gene markers SCARA5, CD248 with a NS-Forest FBeta value of 0.85.") +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: () + +AnnotationAssertion(Annotation( "https://doi.org/10.5281/zenodo.11165918") rdfs:comment "A CCL3-positive alveolar macrophage in the Human Lung has the gene markers TNIP3, CXCL5 with a NS-Forest FBeta value of 0.67.") +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: () + +AnnotationAssertion(Annotation( "https://doi.org/10.5281/zenodo.11165918") rdfs:comment "A metallothionein-positive alveolar macrophage in the Human Lung has the gene markers HMOX1, HPGD with a NS-Forest FBeta value of 0.41.") +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (NS forest marker set of alveolar adventitial fibroblast (Human Lung).) AnnotationAssertion( "0.85") AnnotationAssertion(rdfs:label "NS forest marker set of alveolar adventitial fibroblast (Human Lung).") SubClassOf( ) -SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (NS forest marker set of alveolar type 1 fibroblast cell (Human Lung).) AnnotationAssertion( "0.7") AnnotationAssertion(rdfs:label "NS forest marker set of alveolar type 1 fibroblast cell (Human Lung).") SubClassOf( ) -SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (NS forest marker set of alveolar macrophage (Human Lung).) AnnotationAssertion( "0.8") AnnotationAssertion(rdfs:label "NS forest marker set of alveolar macrophage (Human Lung).") SubClassOf( ) -SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (NS forest marker set of CCL3-positive alveolar macrophage (Human Lung).) AnnotationAssertion( "0.67") AnnotationAssertion(rdfs:label "NS forest marker set of CCL3-positive alveolar macrophage (Human Lung).") SubClassOf( ) -SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (NS forest marker set of metallothionein-positive alveolar macrophage (Human Lung).) AnnotationAssertion( "0.41") AnnotationAssertion(rdfs:label "NS forest marker set of metallothionein-positive alveolar macrophage (Human Lung).") SubClassOf( ) -SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) # Class: (NS forest marker set of cell (Human Lung).) AnnotationAssertion( "0.26") AnnotationAssertion(rdfs:label "NS forest marker set of cell (Human Lung).") SubClassOf( ) -SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectIntersectionOf(ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) ) \ No newline at end of file diff --git a/src/patterns/dosdp-patterns/MarkersToCells.yaml b/src/patterns/dosdp-patterns/MarkersToCells.yaml index 0729771..2881f4b 100644 --- a/src/patterns/dosdp-patterns/MarkersToCells.yaml +++ b/src/patterns/dosdp-patterns/MarkersToCells.yaml @@ -3,37 +3,47 @@ pattern_iri: http://purl.obolibrary.org/obo/cl/MarkersToCells.yaml description: "Adds marker sets to cell types logically and documentation" classes: + "cell": "CL:0000000" "thing": "owl:Thing" "Metazoa": "NCBITaxon:33208" relations: has part: "BFO:0000051" - has characterizing marker set: "RO:0015004" - present in taxon: "RO:0002175" + has_characterizing_marker_set: "RO:0015004" +# present in taxon: "RO:0002175" + +annotationProperties: + present_in_taxon: "RO:0002175" vars: - species: "'Metazoa'" + Cell_type: "'cell'" + Species: "'Metazoa'" has_characterization_set: "'thing'" +list_vars: + Marker_set: "'sequence_feature'" + data_vars: - Marker_set_xref: "xsd:string" +# Marker_set_xref: "xsd:string" Organ: "xsd:string" Species_abbv: "xsd:string" FBeta_confidence_score: "xsd:string" - Cell_type: "xsd:string" +# Cell_type: "xsd:string" + +data_list_vars: + Marker_set_xref: "xsd:string" internal_vars: - var_name: Minimal_markers_cat - input: Minimal_markers_label + input: Marker_set apply: join: sep: ', ' logical_axioms: - axiom_type: subClassOf - text: "('present in taxon' some %s) and ('has characterizing marker set' some %s)" + text: "'has_characterizing_marker_set' some %s" vars: - - species - has_characterization_set comment: @@ -45,3 +55,9 @@ comment: - Minimal_markers_cat - FBeta_confidence_score xrefs: Marker_set_xref + +#annotations: +# - annotationProperty: present_in_taxon +# text: "%s" +# vars: +# - Species \ No newline at end of file diff --git a/src/patterns/pattern.owl b/src/patterns/pattern.owl index 3eefdfe..551d5b0 100644 --- a/src/patterns/pattern.owl +++ b/src/patterns/pattern.owl @@ -8,9 +8,14 @@ Prefix(rdfs:=) Ontology( -Declaration(Class()) -Declaration(ObjectProperty()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(ObjectProperty()) +Declaration(ObjectProperty()) +Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) +Declaration(AnnotationProperty()) @@ -18,11 +23,19 @@ Declaration(AnnotationProperty()) # Classes ############################ -# Class: (Part of 'example') +# Class: () -AnnotationAssertion( "example"^^xsd:string) -AnnotationAssertion(rdfs:label "Part of 'example'"^^xsd:string) -EquivalentClasses( ObjectSomeValuesFrom( owl:Thing)) +AnnotationAssertion( "NSForestMarkers"^^xsd:string) +AnnotationAssertion(Annotation( "xsd:string"^^xsd:string) rdfs:comment "A 'cell' in the xsd:string xsd:string has the gene markers 'sequence_feature' with a NS-Forest FBeta value of xsd:string."^^xsd:string) +SubClassOf( ObjectSomeValuesFrom( owl:Thing)) + +# Class: (NS forest marker set of xsd:string (xsd:string xsd:string).) + +AnnotationAssertion( "xsd:double"^^xsd:string) +AnnotationAssertion( "NSForestMarkers"^^xsd:string) +AnnotationAssertion(rdfs:label "NS forest marker set of xsd:string (xsd:string xsd:string)."^^xsd:string) +SubClassOf( owl:Thing) +SubClassOf( ObjectSomeValuesFrom( )) ) \ No newline at end of file diff --git a/src/scripts/dosdp_template_generator.py b/src/scripts/dosdp_template_generator.py index aefd239..7395146 100644 --- a/src/scripts/dosdp_template_generator.py +++ b/src/scripts/dosdp_template_generator.py @@ -29,7 +29,7 @@ def generate_nsforest_markers_template(output_filepath: str): "Species_abbv": row["Species_abbv"], "Organ_region": row["Organ_region"], "Parent": row["Parent"], - "FBeta_confidence_score": row["FBeta_confidence_score"] + "FBeta_confidence_score": row["FBeta_confidence_score"], }) class_robot_template = pd.DataFrame.from_records(class_template) @@ -42,13 +42,13 @@ def generate_markers_to_cells_template(output_filepath: str): Args: output_filepath: output file path """ - cl_ontology = _init_graph(CL_URL) + # cl_ontology = _init_graph(CL_URL) source = read_table_to_dict(MARKERS_SOURCE_PATH) class_template = [] for row in source: class_template.append({ "defined_class": row["class"], - "Cell_type": get_cl_label(cl_ontology, row["class"]), + "Cell_type": row["class"], "has_characterization_set": row["Marker_set"], "Marker_set": row["Minimal_markers_label"], "Organ": row["Organ"], @@ -97,6 +97,7 @@ def extract_gene_terms(output_filepath: str = None): Extracts gene terms from the source markers template. Args: output_filepath: output file path + Returns: set of gene term ids """ template = read_table_to_dict(MARKERS_SOURCE_PATH) gene_terms = set() @@ -116,6 +117,7 @@ def extract_gene_terms(output_filepath: str = None): parser_generate = subparsers.add_parser("generate", description="Template generator") parser_generate.add_argument("-t", "--template", type=str, help="Name of the template to generate") + parser_generate.add_argument("-a", "--agreed", action="store_true", help="Generate only the CL agreed markers") parser_generate.add_argument("-o", "--out", type=str, help="Output file path") parser_terms = subparsers.add_parser("terms", description="Template terms extractor") diff --git a/src/scripts/robot_template_generator.py b/src/scripts/robot_template_generator.py index 7d84f20..00813bf 100644 --- a/src/scripts/robot_template_generator.py +++ b/src/scripts/robot_template_generator.py @@ -2,7 +2,6 @@ import argparse import pandas as pd -import anndata as ad from dosdp_template_generator import extract_gene_terms from file_utils import read_table_to_dict @@ -19,6 +18,8 @@ def extract_genes_from_anndata(anndata_path, gene_name_column, prefix, output_pa prefix: prefix for the gene IDs (such as ensembl or ncbigene). output_path: path to the output file. """ + import anndata as ad # Importing anndata here to avoid unnecessary dependency in the main script that cause ODK failure + if os.path.exists(anndata_path): anndata = ad.read_h5ad(anndata_path) elif os.path.exists(SHARED_DRIVE): @@ -37,14 +38,26 @@ def extract_genes_from_anndata(anndata_path, gene_name_column, prefix, output_pa def generate_genes_robot_template(input_files: list, output_filepath: str): + robot_template_seed = {'ID': 'ID', + 'TYPE': 'SC %', + 'NAME': 'A rdfs:label', + 'SYNONYMS': 'A oboInOwl:hasExactSynonym SPLIT=|' + } + dl = [robot_template_seed] + used_genes = extract_gene_terms() - gene_subset = [] + found_genes = [] for input_file in input_files: records = read_table_to_dict(input_file) for record in records: - if record['ID'] in used_genes: - gene_subset.append(record) - df = pd.DataFrame(gene_subset, columns=["ID", "TYPE", "NAME", "SYNONYMS"]) + if record['ID'] in used_genes and record['ID'] not in found_genes: + dl.append(record) + found_genes.append(record['ID']) + missing_genes = used_genes - set(found_genes) + if missing_genes: + print(f"Missing genes: {missing_genes}") + raise ValueError(f"Following genes couldn't be found in the reference DBs: {missing_genes}") + df = pd.DataFrame(dl) df.to_csv(output_filepath, sep="\t", index=False)